WorldWideScience

Sample records for technology experimental design

  1. Technological issues and experimental design of gene association studies.

    Science.gov (United States)

    Distefano, Johanna K; Taverna, Darin M

    2011-01-01

    Genome-wide association studies (GWAS), in which thousands of single-nucleotide polymorphisms (SNPs) spanning the genome are genotyped in individuals who are phenotypically well characterized, -currently represent the most popular strategy for identifying gene regions associated with common -diseases and related quantitative traits. Improvements in technology and throughput capability, development of powerful statistical tools, and more widespread acceptance of pooling-based genotyping approaches have led to greater utilization of GWAS in human genetics research. However, important considerations for optimal experimental design, including selection of the most appropriate genotyping platform, can enhance the utility of the approach even further. This chapter reviews experimental and technological issues that may affect the success of GWAS findings and proposes strategies for developing the most comprehensive, logical, and cost-effective approaches for genotyping given the population of interest.

  2. Intermediate experimental vehicle, ESA program aerodynamics-aerothermodynamics key technologies for spacecraft design and successful flight

    Science.gov (United States)

    Dutheil, Sylvain; Pibarot, Julien; Tran, Dac; Vallee, Jean-Jacques; Tribot, Jean-Pierre

    2016-07-01

    With the aim of placing Europe among the world's space players in the strategic area of atmospheric re-entry, several studies on experimental vehicle concepts and improvements of critical re-entry technologies have paved the way for the flight of an experimental space craft. The successful flight of the Intermediate eXperimental Vehicle (IXV), under ESA's Future Launchers Preparatory Programme (FLPP), is definitively a significant step forward from the Atmospheric Reentry Demonstrator flight (1998), establishing Europe as a key player in this field. The IXV project objectives were the design, development, manufacture and ground and flight verification of an autonomous European lifting and aerodynamically controlled reentry system, which is highly flexible and maneuverable. The paper presents, the role of aerodynamics aerothermodynamics as part of the key technologies for designing an atmospheric re-entry spacecraft and securing a successful flight.

  3. Designation and Implementation of Microcomputer Principle and Interface Technology Virtual Experimental Platform Website

    Science.gov (United States)

    Gao, JinYue; Tang, Yin

    This paper explicitly discusses the designation and implementation thought and method of Microcomputer Principle and Interface Technology virtual experimental platform website construction. The instructional design of this platform mainly follows with the students-oriented constructivism learning theory, and the overall structure is subject to the features of teaching aims, teaching contents and interactive methods. Virtual experiment platform production and development should fully take the characteristics of network operation into consideration and adopt relevant technologies to improve the effect and speed of network software application in internet.

  4. Experimental Design of Electrocoagulation and Magnetic Technology for Enhancing Suspended Solids Removal from Synthetic Wastewater

    Directory of Open Access Journals (Sweden)

    Moh Faiqun Ni'am

    2014-10-01

    Full Text Available Design of experiments (DOE is one of the statistical method that is used as a tool to enhance and improve experimental quality. The changes to the variables of a process or system is supposed to give the optimal result (response and quite satisfactory. Experimental design can defined as a test or series of test series by varying the input variables (factors of a process that can known to cause changes in output (response. This paper presents the results of experimental design of wastewater treatment by electrocoagulation (EC technique. A combined magnet and electrocoagulation (EC technology were designed to increase settling velocity and to enhance suspended solid removal efficiencies from wastewater samples. In this experiment, a synthetic wastewater samples were prepared by mixing 700 mg of the milk powder in one litre of water and treated by using an acidic buffer solution. The monopolar iron (Fe plate anodes and cathodes were employed as electrodes. Direct current was varied in a range of between 0.5 and 1.1 A, and flowrate in a range of between 1.00 to 3.50 mL/s. One permanent magnets namely AlNiCo with a magnetic strength of 0.16T was used in this experiment. The results show that the magnetic field and the flowrate have major influences on suspended solids removal. The efficiency removals of suspended solids, turbidity and COD removal efficiencies at optimum conditions were found to be more than 85%, 95%, and 75%, respectively.

  5. Experimental Design for Evaluating Selected Nondestructive Measurement Technologies - Advanced Reactor Technology Milestone: M3AT-16PN2301043

    Energy Technology Data Exchange (ETDEWEB)

    Ramuhalli, Pradeep [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hirt, Evelyn H. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Pitman, Stan G. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Dib, Gerges [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Roy, Surajit [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Good, Morris S. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Walker, Cody M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2016-07-16

    The harsh environments in advanced reactors (AdvRx) increase the possibility of degradation of safety-critical passive components, and therefore pose a particular challenge for deployment and extended operation of these concepts. Nondestructive evaluation technologies are an essential element for obtaining information on passive component condition in AdvRx, with the development of sensor technologies for nondestructively inspecting AdvRx passive components identified as a key need. Given the challenges posed by AdvRx environments and the potential needs for reducing the burden posed by periodic in-service inspection of hard-to-access and hard-to-replace components, a viable solution may be provided by online condition monitoring of components. This report identifies the key challenges that will need to be overcome for sensor development in this context, and documents an experimental plan for sensor development, test, and evaluation. The focus of initial research and development is on sodium fast reactors, with the eventual goal of the research being developing the necessary sensor technology, quantifying sensor survivability and long-term measurement reliability for nondestructively inspecting critical components. Materials for sensor development that are likely to withstand the harsh environments are described, along with a status on the fabrication of reference specimens, and the planned approach for design and evaluation of the sensor and measurement technology.

  6. Experimental design

    Science.gov (United States)

    Lim, H. S.

    1983-01-01

    The design of long life, low weight nickel cadmium cells is studied. The status of a program to optimize nickel electrodes for the best performance is discussed. The pore size of the plaque, the mechanical strength and active material loading are considered in depth.

  7. Performance of Different Experimental Absorber Designs in Absorption Heat Pump Cycle Technologies: A Review

    Directory of Open Access Journals (Sweden)

    Jonathan Ibarra-Bahena

    2014-02-01

    Full Text Available The absorber is a major component of absorption cycle systems, and its performance directly impacts the overall size and energy supplies of these devices. Absorption cooling and heating cycles have different absorber design requirements: in absorption cooling systems, the absorber works close to ambient temperature, therefore, the mass transfer is the most important phenomenon in order to reduce the generator size; on the other hand, in heat transformer absorption systems, is important to recover the heat delivered by exothermic reactions produced in the absorber. In this paper a review of the main experimental results of different absorber designs reported in absorption heat pump cycles is presented.

  8. Design Considerations and Experimental Verification of a Rail Brake Armature Based on Linear Induction Motor Technology

    Science.gov (United States)

    Sakamoto, Yasuaki; Kashiwagi, Takayuki; Hasegawa, Hitoshi; Sasakawa, Takashi; Fujii, Nobuo

    This paper describes the design considerations and experimental verification of an LIM rail brake armature. In order to generate power and maximize the braking force density despite the limited area between the armature and the rail and the limited space available for installation, we studied a design method that is suitable for designing an LIM rail brake armature; we considered adoption of a ring winding structure. To examine the validity of the proposed design method, we developed a prototype ring winding armature for the rail brakes and examined its electromagnetic characteristics in a dynamic test system with roller rigs. By repeating various tests, we confirmed that unnecessary magnetic field components, which were expected to be present under high speed running condition or when a ring winding armature was used, were not present. Further, the necessary magnetic field component and braking force attained the desired values. These studies have helped us to develop a basic design method that is suitable for designing the LIM rail brake armatures.

  9. Emerging experimental and computational technologies for purpose designed engineering of photosynthetic prokaryotes

    KAUST Repository

    Lindblad, Peter

    2016-01-25

    With recent advances in synthetic molecular tools to be used in photosynthetic prokaryotes, like cyanobacteria, it is possible to custom design and construct microbial cells for specific metabolic functions. This cross-disciplinary area of research has emerged within the interfaces of advanced genetic engineering, computational science, and molecular biotechnology. We have initiated the development of a genetic toolbox, using a synthetic biology approach, to custom design, engineer and construct cyanobacteria for selected function and metabolism. One major bottleneck is a controlled transcription and translation of introduced genetic constructs. An additional major issue is genetic stability. I will present and discuss recent progress in our development of genetic tools for advanced cyanobacterial biotechnology. Progress on understanding the electron pathways in native and engineered cyanobacterial enzymes and heterologous expression of non-native enymzes in cyanobacterial cells will be highlighted. Finally, I will discuss our attempts to merge synthetic biology with synthetic chemistry to explore fundamantal questions of protein design and function.

  10. Systems biology: experimental design.

    Science.gov (United States)

    Kreutz, Clemens; Timmer, Jens

    2009-02-01

    Experimental design has a long tradition in statistics, engineering and life sciences, dating back to the beginning of the last century when optimal designs for industrial and agricultural trials were considered. In cell biology, the use of mathematical modeling approaches raises new demands on experimental planning. A maximum informative investigation of the dynamic behavior of cellular systems is achieved by an optimal combination of stimulations and observations over time. In this minireview, the existing approaches concerning this optimization for parameter estimation and model discrimination are summarized. Furthermore, the relevant classical aspects of experimental design, such as randomization, replication and confounding, are reviewed.

  11. Experimental Design Research

    DEFF Research Database (Denmark)

    of experimental approaches and their utility in this domain, and brings together analytical approaches to promote an integrated understanding. The book also investigates where these approaches lead to and how they link design research more fully with other disciplines (e.g. psychology, cognition, sociology......This book presents a new, multidisciplinary perspective on and paradigm for integrative experimental design research. It addresses various perspectives on methods, analysis and overall research approach, and how they can be synthesized to advance understanding of design. It explores the foundations......, computer science, management). Above all, the book emphasizes the integrative nature of design research in terms of the methods, theories, and units of study—from the individual to the organizational level. Although this approach offers many advantages, it has inherently led to a situation in current...

  12. Teaching experimental design.

    Science.gov (United States)

    Fry, Derek J

    2014-01-01

    Awareness of poor design and published concerns over study quality stimulated the development of courses on experimental design intended to improve matters. This article describes some of the thinking behind these courses and how the topics can be presented in a variety of formats. The premises are that education in experimental design should be undertaken with an awareness of educational principles, of how adults learn, and of the particular topics in the subject that need emphasis. For those using laboratory animals, it should include ethical considerations, particularly severity issues, and accommodate learners not confident with mathematics. Basic principles, explanation of fully randomized, randomized block, and factorial designs, and discussion of how to size an experiment form the minimum set of topics. A problem-solving approach can help develop the skills of deciding what are correct experimental units and suitable controls in different experimental scenarios, identifying when an experiment has not been properly randomized or blinded, and selecting the most efficient design for particular experimental situations. Content, pace, and presentation should suit the audience and time available, and variety both within a presentation and in ways of interacting with those being taught is likely to be effective. Details are given of a three-day course based on these ideas, which has been rated informative, educational, and enjoyable, and can form a postgraduate module. It has oral presentations reinforced by group exercises and discussions based on realistic problems, and computer exercises which include some analysis. Other case studies consider a half-day format and a module for animal technicians. © The Author 2014. Published by Oxford University Press on behalf of the Institute for Laboratory Animal Research. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  13. Designing Human Technologies

    DEFF Research Database (Denmark)

    Simonsen, Jesper

    and the design process, in ethical and society-related concerns, and in evaluating how designs fulfill needs and solve problems. Designing Human Technologies subscribes to a broad technology concept including information and communication, mobile, environmental/sustainable and energy technologies......, the Humanities, and Social Science. The initiative broadens the perspective of IS and recognize reflections on aesthetics, ethics, values, connections to politics, and strategies for enabling a better future as legitimate parts of the research agenda. Designing Human Technologies is a design-oriented Strategic...... a shared interdisciplinary research and educational collaboration. As a creative research initiative it focuses on change and innovative thinking. The innovativeness is a result of the strongly interdisciplinary perspective which is at the heart of Designing Human Technologies. Designing Human Technologies...

  14. Designing Human Technologies

    DEFF Research Database (Denmark)

    Simonsen, Jesper

    and the design process, in ethical and society-related concerns, and in evaluating how designs fulfill needs and solve problems. Designing Human Technologies subscribes to a broad technology concept including information and communication, mobile, environmental/sustainable and energy technologies......, the Humanities, and Social Science. The initiative broadens the perspective of IS and recognize reflections on aesthetics, ethics, values, connections to politics, and strategies for enabling a better future as legitimate parts of the research agenda. Designing Human Technologies is a design-oriented Strategic...... and technologies relating to performances and experiences, urban design, climate adaptation, etc. The research takes a process-oriented and participatory approach and involves interaction between different user interests and designs. It is based on empirical, typical case- and action research-oriented studies...

  15. Ethics and technology design

    DEFF Research Database (Denmark)

    Albrechtslund, Anders

    This article offers a discussion of the connection between technology and values and, specifically, I take a closer look at ethically sound design. In order to bring the discussion into a concrete context, the theory of Value Sensitive Design (VSD) will be the focus point. To illustrate my argument...... concerning design ethics, the discussion involves a case study of an augmented window, designed by the VSD Research Lab, which has turned out to be a potentially surveillanceenabling technology. I call attention to a “positivist problem” that has to do with the connection between the design context...... of design ethics, is intended as a constructive criticism, which can hopefully contribute to the further development of design ethics....

  16. Ethics and technology design

    DEFF Research Database (Denmark)

    Albrechtslund, Anders

    2007-01-01

    This article offers a discussion of the connection between technology and values and, specifically, I take a closer look at ethically sound design. In order to bring the discussion into a concrete context, the theory of Value Sensitive Design (VSD) will be the focus point. To illustrate my argument...... concerning design ethics, the discussion involves a case study of an augmented window, designed by the VSD Research Lab, which has turned out to be a potentially surveillance-enabling technology. I call attention to a "positivist problem" that has to do with the connection between the design context...... of design ethics, is intended as a constructive criticism, which can hopefully contribute to the further development of design ethics....

  17. Ethics and technology design

    DEFF Research Database (Denmark)

    Albrechtslund, Anders

    This article offers a discussion of the connection between technology and values and, specifically, I take a closer look at ethically sound design. In order to bring the discussion into a concrete context, the theory of Value Sensitive Design (VSD) will be the focus point. To illustrate my argument...... concerning design ethics, the discussion involves a case study of an augmented window, designed by the VSD Research Lab, which has turned out to be a potentially surveillanceenabling technology. I call attention to a “positivist problem” that has to do with the connection between the design context...... of design ethics, is intended as a constructive criticism, which can hopefully contribute to the further development of design ethics....

  18. Development of a Model for Measuring Scientific Processing Skills Based on Brain-Imaging Technology: Focused on the Experimental Design Process

    Science.gov (United States)

    Lee, Il-Sun; Byeon, Jung-Ho; Kim, Young-shin; Kwon, Yong-Ju

    2014-01-01

    The purpose of this study was to develop a model for measuring experimental design ability based on functional magnetic resonance imaging (fMRI) during biological inquiry. More specifically, the researchers developed an experimental design task that measures experimental design ability. Using the developed experimental design task, they measured…

  19. Deoxynivalenol & Deoxynivalenol-3-Glucoside Mitigation through Bakery Production Strategies: Effective Experimental Design within Industrial Rusk-Making Technology.

    Science.gov (United States)

    Generotti, Silvia; Cirlini, Martina; Malachova, Alexandra; Sulyok, Michael; Berthiller, Franz; Dall'Asta, Chiara; Suman, Michele

    2015-07-24

    In the scientific field, there is a progressive awareness about the potential implications of food processing on mycotoxins especially concerning thermal treatments. High temperatures may cause, in fact, transformation or degradation of these compounds. This work is aimed to study the fate of mycotoxins during bakery processing, focusing on deoxynivalenol (DON) and deoxynivalenol-3-glucoside (DON3Glc), along the chain of industrial rusk production. Starting from naturally contaminated bran, we studied how concentrations of DON and DON3Glc are influenced by modifying ingredients and operative conditions. The experiments were performed using statistical Design of Experiment (DoE) schemes to synergistically explore the relationship between mycotoxin reduction and the indicated processing transformation parameters. All samples collected during pilot plant experiments were analyzed with an LC-MS/MS multimycotoxin method. The obtained model shows a good fitting, giving back relevant information in terms of optimization of the industrial production process, in particular suggesting that time and temperature in baking and toasting steps are highly relevant for minimizing mycotoxin level in rusks. A reduction up to 30% for DON and DON3Glc content in the finished product was observed within an acceptable technological range.

  20. True Experimental Design.

    Science.gov (United States)

    Huck, Schuyler W.

    1991-01-01

    This poem, with stanzas in limerick form, refers humorously to the many threats to validity posed by problems in research design, including problems of sample selection, data collection, and data analysis. (SLD)

  1. Experimental design a chemometric approach

    CERN Document Server

    Deming, SN

    1987-01-01

    Now available in a paperback edition is a book which has been described as ``...an exceptionally lucid, easy-to-read presentation... would be an excellent addition to the collection of every analytical chemist. I recommend it with great enthusiasm.'' (Analytical Chemistry). Unlike most current textbooks, it approaches experimental design from the point of view of the experimenter, rather than that of the statistician. As the reviewer in `Analytical Chemistry' went on to say: ``Deming and Morgan should be given high praise for bringing the principles of experimental design to the level of the p

  2. QUBIC Technological Design Report

    CERN Document Server

    Aumont, J; Battaglia, P; Battistelli, E S; Baù, A; Bélier, B; Bennett, D; Bergé, L; Bernard, J Ph; Bersanelli, M; Bigot-Sazy, M A; Bleurvacq, N; Bordier, G; Brossard, J; Bunn, E F; Buzi, D; Buzzelli, A; Cammilleri, D; Cavaliere, F; Chanial, P; Chapron, C; Coppi, G; Coppolecchia, A; Couchot, F; D'Agostino, R; D'Alessandro, G; de Bernardis, P; De Gasperis, G; De Petris, M; Decourcelle, T; Del Torto, F; Dumoulin, L; Etchegoyen, A; Franceschet, C; Garcia, B; Gault, A; Gayer, D; Gervasi, M; Ghribi, A; Giard, M; Giraud-Héraud, Y; Gradziel, M; Grandsire, L; Hamilton, J Ch; Harari, D; Haynes, V; Henrot-Versillé, S; Holtzer, N; Kaplan, J; Korotkov, A; Lande, J; Loucatos, S; Lowitz, A; Lukovic, V; Maffei, B; Marnieros, S; Martino, J; Masi, S; Medina, M C; McCulloch, M; May, A; Melhuish, S; Mennella, A; Montier, L; Murphy, A; Néel, D; Ng, M W; O'Sullivan, C; Pajot, F; Passerini, A; Pelosi, A; Perbost, C; Perdereau, O; Piacentini, F; Piat, M; Piccirillo, L; Pisano, G; Prêle, D; Puddu, R; Rambaud, D; Rigaut, O; Romero, G E; Salatino, M; Schillaci, A; Scully, S; Stolpovskiy, M; Tartari, A; Timbie, P; Tristram, M; Tucker, G; Viganò, D; Vittori, N; Voisin, F; Watson, B; Zannoni, M; Zullo, A

    2016-01-01

    QUBIC is an instrument aiming at measuring the B mode polarisation anisotropies at medium scales angular scales (30-200 multipoles). The search for the primordial CMB B-mode polarization signal is challenging, because of many difficulties: smallness of the expected signal, instrumental systematics that could possibly induce polarization leakage from the large E signal into B, brighter than anticipated polarized foregrounds (dust) reducing to zero the initial hope of finding sky regions clean enough to have a direct primordial B-modes observation. The QUBIC instrument is designed to address all aspects of this challenge with a novel kind of instrument, a Bolometric Interferometer, combining the background-limited sensitivity of Transition-Edge-Sensors and the control of systematics allowed by the observation of interference fringe patterns, while operating at two frequencies to disentangle polarized foregrounds from primordial B mode polarization. Its characteristics are described in details in this Technologi...

  3. Development of satiating and palatable high-protein meat products by using experimental design in food technology

    Directory of Open Access Journals (Sweden)

    Hanne Kristine Sivertsen

    2010-11-01

    Full Text Available Background and objectives: Foods high in protein are known to satiate more fully than foods high in other constituents. One challenge with these types of food is the degree of palatability. This study was aimed at developing the frankfurter style of sausages that would regulate food intake as well as being the preferred food choice of the consumer. Design and measures: 16 sausage varieties with commercial (PE% 20 or higher amount of protein (PE% 40, being modified with vegetable fat (3% of rapeseed oil, and smoked or not, underwent a sensory descriptive analysis, in which the information was used to choose a subsample of four sausages for a satiety test. Twenty-seven subjects were recruited based on liking and frequency of sausage consumption. The participants ranged in age from 20 to 28, and in body mass index (BMI between 19.6 and 30.9. The students were served a sausage meal for five consecutive days and then filled out a questionnaire to describe their feelings of hunger, satiety, fullness, desire to eat an their prospective consumption on a visual analogue scale (VAS starting from right before, right after the meal, every half hour for 4 h until the next meal was served, and right after the second meal. Results and conclusion: The higher protein sausages were less juicy, oily, fatty, adhesive, but harder and more granular than with lower amount of protein. The high-protein sausages were perceived as more satiating the first 90 min after the first meal. Some indication of satiety effect of added oil versus meat fat. No significant differences in liking among the four sausage varieties.

  4. How Technology Influences Interior Design.

    Science.gov (United States)

    McDavitt, Tish

    1999-01-01

    Examines telecommunication technology's influences on interior school design and effective learning, and discusses how to implement this technology into the school. Building the infrastructure to support telecommunications in an educational setting and the importance of effective lighting are discussed. (GR)

  5. How Technology Influences Interior Design.

    Science.gov (United States)

    McDavitt, Tish

    1999-01-01

    Examines telecommunication technology's influences on interior school design and effective learning, and discusses how to implement this technology into the school. Building the infrastructure to support telecommunications in an educational setting and the importance of effective lighting are discussed. (GR)

  6. Elements of Bayesian experimental design

    Energy Technology Data Exchange (ETDEWEB)

    Sivia, D.S. [Rutherford Appleton Lab., Oxon (United Kingdom)

    1997-09-01

    We consider some elements of the Bayesian approach that are important for optimal experimental design. While the underlying principles used are very general, and are explained in detail in a recent tutorial text, they are applied here to the specific case of characterising the inferential value of different resolution peakshapes. This particular issue was considered earlier by Silver, Sivia and Pynn (1989, 1990a, 1990b), and the following presentation confirms and extends the conclusions of their analysis.

  7. Technology design of composite parts

    OpenAIRE

    K. Karjust; R. Küttner; M. Pohlak

    2007-01-01

    Purpose: Purpose of this paper is to optimize the design of the manufacturing technology process of large composite plastic products. One of the key problems is how to integrate computer-based product design and planning of the technology process.Design/methodology/approach: In the current study the Neural Network meta-modelling technique has been used. The optimization of the plastic sheet and its strengthening layer thickness has been performed using the surrogate design model. For modeling...

  8. Inclusive Design for Assistive Technology

    DEFF Research Database (Denmark)

    Herriott, Richard

    2014-01-01

    Objectives/focus/background: Design for Assistive Technology (AT) requires a special focus on user-requirements during product development. Inclusive Design theory and methodology thus has been relevant to AT design processes. Research in AT design has both drawn from and added to the ID knowledge...... the question of whether AT design processes fit neatly into a model created for a different context . Semi-structured interviews were carried out with eight/nine designers of assistive technology. This provided raw data concerning the processes used by the designers in a range of products including...

  9. Theoretical and experimental fundamentals of designing promising technological equipment to improve efficiency and environmental safety of highly viscous oil recovery from deep oil reservoirs

    Science.gov (United States)

    Moiseyev, V. A.; Nazarov, V. P.; Zhuravlev, V. Y.; Zhuykov, D. A.; Kubrikov, M. V.; Klokotov, Y. N.

    2016-12-01

    The development of new technological equipment for the implementation of highly effective methods of recovering highly viscous oil from deep reservoirs is an important scientific and technical challenge. Thermal recovery methods are promising approaches to solving the problem. It is necessary to carry out theoretical and experimental research aimed at developing oil-well tubing (OWT) with composite heatinsulating coatings on the basis of basalt and glass fibers. We used the method of finite element analysis in Nastran software, which implements complex scientific and engineering calculations, including the calculation of the stress-strain state of mechanical systems, the solution of problems of heat transfer, the study of nonlinear static, the dynamic transient analysis of frequency characteristics, etc. As a result, we obtained a mathematical model of thermal conductivity which describes the steady-state temperature and changes in the fibrous highly porous material with the heat loss by Stefan-Boltzmann's radiation. It has been performed for the first time using the method of computer modeling in Nastran software environments. The results give grounds for further implementation of the real design of the OWT when implementing thermal methods for increasing the rates of oil production and mitigating environmental impacts.

  10. Graphical Models for Quasi-Experimental Designs

    Science.gov (United States)

    Kim, Yongnam; Steiner, Peter M.; Hall, Courtney E.; Su, Dan

    2016-01-01

    Experimental and quasi-experimental designs play a central role in estimating cause-effect relationships in education, psychology, and many other fields of the social and behavioral sciences. This paper presents and discusses the causal graphs of experimental and quasi-experimental designs. For quasi-experimental designs the authors demonstrate…

  11. Teaching experimental design to biologists.

    Science.gov (United States)

    Zolman, J F

    1999-12-01

    The teaching of research design and data analysis to our graduate students has been a persistent problem. A course is described in which students, early in their graduate training, obtain extensive practice in designing experiments and interpreting data. Lecture-discussions on the essentials of biostatistics are given, and then these essentials are repeatedly reviewed by illustrating their applications and misapplications in numerous research design problems. Students critique these designs and prepare similar problems for peer evaluation. In most problems the treatments are confounded by extraneous variables, proper controls may be absent, or data analysis may be incorrect. For each problem, students must decide whether the researchers' conclusions are valid and, if not, must identify a fatal experimental flaw. Students learn that an experiment is a well-conceived plan for data collection, analysis, and interpretation. They enjoy the interactive evaluations of research designs and appreciate the repetitive review of common flaws in different experiments. They also benefit from their practice in scientific writing and in critically evaluating their peers' designs.

  12. Animal husbandry and experimental design.

    Science.gov (United States)

    Nevalainen, Timo

    2014-01-01

    If the scientist needs to contact the animal facility after any study to inquire about husbandry details, this represents a lost opportunity, which can ultimately interfere with the study results and their interpretation. There is a clear tendency for authors to describe methodological procedures down to the smallest detail, but at the same time to provide minimal information on animals and their husbandry. Controlling all major variables as far as possible is the key issue when establishing an experimental design. The other common mechanism affecting study results is a change in the variation. Factors causing bias or variation changes are also detectable within husbandry. Our lives and the lives of animals are governed by cycles: the seasons, the reproductive cycle, the weekend-working days, the cage change/room sanitation cycle, and the diurnal rhythm. Some of these may be attributable to routine husbandry, and the rest are cycles, which may be affected by husbandry procedures. Other issues to be considered are consequences of in-house transport, restrictions caused by caging, randomization of cage location, the physical environment inside the cage, the acoustic environment audible to animals, olfactory environment, materials in the cage, cage complexity, feeding regimens, kinship, and humans. Laboratory animal husbandry issues are an integral but underappreciated part of investigators' experimental design, which if ignored can cause major interference with the results. All researchers should familiarize themselves with the current routine animal care of the facility serving them, including their capabilities for the monitoring of biological and physicochemical environment.

  13. Contemporary design and manufacturing technology

    CERN Document Server

    Wang, Taiyong; Zuo, Dunwen

    2013-01-01

    The special topic volume communicates the latest progress and research results of new theory, new technology, method, equipment and so on in Engineering Technology, and to grasp the updated technological and research trends in internationally. The major topics covered by the special volumes include Advanced Materials and Manufacturing Technologies, Control, Automation and Detection Systems, Advanced Design Technology, Optimization and Modeling. In 80 invited and peer-reviewed papers, mechanical and other engineers describe their recent and current research and results in advanced materials and

  14. Quasi-Experimental Designs for Causal Inference

    Science.gov (United States)

    Kim, Yongnam; Steiner, Peter

    2016-01-01

    When randomized experiments are infeasible, quasi-experimental designs can be exploited to evaluate causal treatment effects. The strongest quasi-experimental designs for causal inference are regression discontinuity designs, instrumental variable designs, matching and propensity score designs, and comparative interrupted time series designs. This…

  15. Participatory Design & Health Information Technology

    DEFF Research Database (Denmark)

    Health Information Technology (HIT) continues to increase in importance as a component of healthcare provision, but designing HIT is complex. The creation of cooperative learning processes for future HIT users is not a simple task. The importance of engaging end users such as health professionals......, in collaboration with a wide range of people, a broad repertoire of methods and techniques to apply PD within multiple domains has been established. This book, Participatory Design & Health Information Technology, presents the contributions of researchers from 5 countries, who share their experience and insights......, patients and relatives in the design process is widely acknowledged, and Participatory Design (PD) is the primary discipline for directly involving people in the technological design process. Exploring the application of PD in HIT is crucial to all those involved in engaging end users in HIT design and...

  16. On Design Technology.

    Science.gov (United States)

    Pace, Glennellen; Larson, Connie

    1992-01-01

    Discusses a child-centered science project in which first-grade students integrate design drawing, construction, mathematics, and language arts to solve engineering problems related to constructing robots. Describes the construction of the robots, follow-up activities, and educational research that supports this approach to teaching. (10…

  17. Designing Real Time Assistive Technologies

    DEFF Research Database (Denmark)

    Sonne, Tobias; Obel, Carsten; Grønbæk, Kaj

    2015-01-01

    design criteria in relation to three core components (sensing, recognizing, and assisting) for designing real time assistive technologies for children with ADHD. Based on these design criteria, we designed the Child Activity Sensing and Training Tool (CASTT), a real time assistive prototype that captures...... activities and assists the child in maintaining attention. From a preliminary evaluation of CASTT with 20 children in several schools, we and found that: 1) it is possible to create a wearable sensor system for children with ADHD that monitors physical and physiological activities in real time; and that 2......) real time assistive technologies have potential to assist children with ADHD in regaining attention in critical school situations....

  18. Designing Real Time Assistive Technologies

    DEFF Research Database (Denmark)

    Sonne, Tobias; Obel, Carsten; Grønbæk, Kaj

    design criteria in relation to three core components (sensing, recognizing, and assisting) for designing real time assistive technologies for children with ADHD. Based on these design criteria, we designed the Child Activity Sensing and Training Tool (CASTT), a real time assistive prototype that captures...... activities and assists the child in maintaining attention. From a preliminary evaluation of CASTT with 20 children in several schools, we and found that: 1) it is possible to create a wearable sensor system for children with ADHD that monitors physical and physiological activities in real time; and that 2......) real time assistive technologies have potential to assist children with ADHD in regaining attention in critical school situations....

  19. Experimental study of MWEDM technology

    Institute of Scientific and Technical Information of China (English)

    DI Shi-chun; HUANG Rui-ning; CHI Guan-xin; ZHAO Wan-sheng

    2005-01-01

    This work deals with an experimental investigation of the machining characteristics of Micro Wire Electrical Discharge Machining (MWEDM). The MWEDM process consists of only one cutting operation varying with machining conditions. Experimental results show that the peak current and pulse duration have an obvious influence on surface roughness and machining time, and they also have an optimum value for the highest cutting speed. The servo reference voltage influences the surface roughness and machining time as well. In particular,the surface characteristics of work-pieces and a micro wire electrode were analyzed in detail too. Utilizing a micro wire electrode with diameter 30μm, MWEDM can machine a micro slot 38μm wide, which proves that the discharge gap can be controlled not more than 4μm. It can also machine micro gears respectively with a module 40μm, thickness 1mm, and a module 100μm, thickness 3.5mm. All kinds of micro shaped holes and complex micro parts can be easily machined as well.

  20. 基于知识网络的教育技术实验平台的设计与实现%Design and implementation of experimental platform with educational technology based on the knowledge network

    Institute of Scientific and Technical Information of China (English)

    陈文沛

    2014-01-01

    总结了教育技术实验教学存在的主要问题,分析了基于知识网络的教育技术实验平台的优越性,介绍了基于知识网络的教育技术实验平台的设计与实现过程。%In this paper, the main problems in experimental teaching with educational technology are introduced; the advantages of experimental platform with educational technology based on the knowledge network are analyzed; design and implementation of experimental platform with educational technology based on the knowledge network are introduced at last.

  1. Technology design of composite parts

    Directory of Open Access Journals (Sweden)

    K. Karjust

    2007-06-01

    Full Text Available Purpose: Purpose of this paper is to optimize the design of the manufacturing technology process of large composite plastic products. One of the key problems is how to integrate computer-based product design and planning of the technology process.Design/methodology/approach: In the current study the Neural Network meta-modelling technique has been used. The optimization of the plastic sheet and its strengthening layer thickness has been performed using the surrogate design model. For modeling and structural analysis of derivative products CAE (ANSYS and CAD (Unigraphics systems are used. The Finite Element Analysis simulation was performed with optimal thickness values to verify the prediction accuracy of a surrogate model.Findings: The optimization model is proposed to control and analyze the calculated technology planning route, the optimal vacuum forming processes, the technology of post-forming operations, strengthening and assembling operations. The design of the new products is tightly integrated with manufacturing aspects. The product family of the large composite plastic products together with the derivate products and their production technologies is designed using proposed methodology. The optimization of the plastic sheet and its strengthening layer thickness has been performed.Practical implications: The most of the methods described in this study are now under development and industrial testing. Development of manufacturing (operation plans for a product family is of great practical importance with many significant cost implications. In design of derivative products for the product family, the nonlinear optimization is used and the detailed description of the product is established. The proposed approach is exemplified by the development of a family of products in Wellspa Inc.Originality/value: Value of this paper is that developed optimization model controls and analyzes the calculated technology planning route.

  2. Experimental design methods for bioengineering applications.

    Science.gov (United States)

    Keskin Gündoğdu, Tuğba; Deniz, İrem; Çalışkan, Gülizar; Şahin, Erdem Sefa; Azbar, Nuri

    2016-01-01

    Experimental design is a form of process analysis in which certain factors are selected to obtain the desired responses of interest. It may also be used for the determination of the effects of various independent factors on a dependent factor. The bioengineering discipline includes many different areas of scientific interest, and each study area is affected and governed by many different factors. Briefly analyzing the important factors and selecting an experimental design for optimization are very effective tools for the design of any bioprocess under question. This review summarizes experimental design methods that can be used to investigate various factors relating to bioengineering processes. The experimental methods generally used in bioengineering are as follows: full factorial design, fractional factorial design, Plackett-Burman design, Taguchi design, Box-Behnken design and central composite design. These design methods are briefly introduced, and then the application of these design methods to study different bioengineering processes is analyzed.

  3. TECHNOLOGY OF EDUCATIONAL EVENTS DESIGNING

    Directory of Open Access Journals (Sweden)

    N. V. Volkova

    2017-01-01

    Full Text Available The aim of the article is to prove and disclose the essence of the author’s technology of educational events designing.Methodology and methods of research. Methodological basis of work is humanitarian approach. The method of pedagogical modeling was used for the model development of educational events influence on pedagogical activity formation. The content analysis of texts descriptions, case-study method, expert estimations of event projects were applied as the main methods of efficiency confirmation of the technology of educational events design.Results and scientific novelty. The characteristics of an educational event are emphasized by means of an empirical way: opening (what a person opens for himself; generation (a result of a personal action; and participation in creation of something "new" (new communications, relations and experience. The structure of technology of educational events design including work with concepts (an educational event, substantial and procedural components is presented. The technology of educational events designing is considered as the process of the well-grounded choice of designing technologies, mutual activity, pedagogical communication, components of educational activity: contents, methods, means, and organizational forms depending on educational aims due to age-specific peculiarities of participants of the educational event. The main conditions providing successful use of the technology are the involvement into joint cognitive activity of all its participants and importance of the events for each of them that qualitatively change the nature of a cognitive process and generate real transformations of the reality.Practical significance. The author’s experience in teaching testifies to introduction of the module «Technology of Design of Educational Events» into the basic educational subject-module «Design Competence of the Teacher» (degree program «Pedagogical Education», considering this module as

  4. Experimental Design and Some Threats to Experimental Validity: A Primer

    Science.gov (United States)

    Skidmore, Susan

    2008-01-01

    Experimental designs are distinguished as the best method to respond to questions involving causality. The purpose of the present paper is to explicate the logic of experimental design and why it is so vital to questions that demand causal conclusions. In addition, types of internal and external validity threats are discussed. To emphasize the…

  5. The Experimental Design Ability Test (EDAT)

    Science.gov (United States)

    Sirum, Karen; Humburg, Jennifer

    2011-01-01

    Higher education goals include helping students develop evidence based reasoning skills; therefore, scientific thinking skills such as those required to understand the design of a basic experiment are important. The Experimental Design Ability Test (EDAT) measures students' understanding of the criteria for good experimental design through their…

  6. Quasi experimental designs in pharmacist intervention research.

    Science.gov (United States)

    Krass, Ines

    2016-06-01

    Background In the field of pharmacist intervention research it is often difficult to conform to the rigorous requirements of the "true experimental" models, especially the requirement of randomization. When randomization is not feasible, a practice based researcher can choose from a range of "quasi-experimental designs" i.e., non-randomised and at time non controlled. Objective The aim of this article was to provide an overview of quasi-experimental designs, discuss their strengths and weaknesses and to investigate their application in pharmacist intervention research over the previous decade. Results In the literature quasi experimental studies may be classified into five broad categories: quasi-experimental design without control groups; quasi-experimental design that use control groups with no pre-test; quasi-experimental design that use control groups and pre-tests; interrupted time series and stepped wedge designs. Quasi-experimental study design has consistently featured in the evolution of pharmacist intervention research. The most commonly applied of all quasi experimental designs in the practice based research literature are the one group pre-post-test design and the non-equivalent control group design i.e., (untreated control group with dependent pre-tests and post-tests) and have been used to test the impact of pharmacist interventions in general medications management as well as in specific disease states. Conclusion Quasi experimental studies have a role to play as proof of concept, in the pilot phases of interventions when testing different intervention components, especially in complex interventions. They serve to develop an understanding of possible intervention effects: while in isolation they yield weak evidence of clinical efficacy, taken collectively, they help build a body of evidence in support of the value of pharmacist interventions across different practice settings and countries. However, when a traditional RCT is not feasible for

  7. Experimental Design for the LATOR Mission

    Science.gov (United States)

    Turyshev, Slava G.; Shao, Michael; Nordtvedt, Kenneth, Jr.

    2004-01-01

    This paper discusses experimental design for the Laser Astrometric Test Of Relativity (LATOR) mission. LATOR is designed to reach unprecedented accuracy of 1 part in 10(exp 8) in measuring the curvature of the solar gravitational field as given by the value of the key Eddington post-Newtonian parameter gamma. This mission will demonstrate the accuracy needed to measure effects of the next post-Newtonian order (near infinity G2) of light deflection resulting from gravity s intrinsic non-linearity. LATOR will provide the first precise measurement of the solar quadrupole moment parameter, J(sub 2), and will improve determination of a variety of relativistic effects including Lense-Thirring precession. The mission will benefit from the recent progress in the optical communication technologies the immediate and natural step above the standard radio-metric techniques. The key element of LATOR is a geometric redundancy provided by the laser ranging and long-baseline optical interferometry. We discuss the mission and optical designs, as well as the expected performance of this proposed mission. LATOR will lead to very robust advances in the tests of Fundamental physics: this mission could discover a violation or extension of general relativity, or reveal the presence of an additional long range interaction in the physical law. There are no analogs to the LATOR experiment; it is unique and is a natural culmination of solar system gravity experiments.

  8. Design of Formulated Products: Experimental Component

    DEFF Research Database (Denmark)

    Conte, Elisa; Gani, Rafiqul; Cheng, Y. S.

    2012-01-01

    : computer-aided design (Stage 1), which generates a list of feasible candidates, experimental planning (Stage 2), which generates a list of experiments and checks the available experimental set-ups, and experimental testing (Stage 3), which measures the necessary data and verifies the desirable attributes...

  9. Experimental design and priority PLS regression

    DEFF Research Database (Denmark)

    Høskuldsson, Agnar

    1996-01-01

    Rules, ideas and algorithms of the H-principle are used to analyse models that are derived from experimental design. Some of the basic ideas of experimental design are reviewed and related to the methodology of the H-principle. New methods of optimal response surfaces are developed....

  10. Light Experimental Supercruiser Conceptual Design

    Science.gov (United States)

    1976-07-01

    RADIUS-200 TOGW Fifun 118. Arrow Point Design Ptnittmn* Carpet 193 4.3 VEHICLE PARAMETRIC TRADES (Continued) Sustained Load Factor--The third...0.06 ^s’ ^60^^ ^ ^**«» ^ >^^»M00 «^ /^ / —~ <. xf ’"»^C^ ^ -< >^ X*** Fifun 120. Arrow Su$t»lmd Lo§d factor Vtrwt

  11. Some Thoughts on Experimental Design.

    Science.gov (United States)

    Stern, Claudio D

    2017-01-01

    Perhaps even more important than the techniques themselves are the quality of the biological questions asked and the design of the experiments devised to answer them. This chapter summarizes some of the key issues and also touches on how the same principles affect scholarly use of the scientific literature and good peer-reviewing practices.

  12. Experimental Design: Review and Comment.

    Science.gov (United States)

    1984-02-01

    and early work in the subject was done by Wald (1943), Hotelling (1944), and Elfving (1952). The major contributions to the area, however, were made by...Kiefer (1958, 1959) and Kiefer and Wolfowitz (1959, 1960), who synthesized and greatly extended the previous work. Although the ideas of optimal...design theory is the general equivalence theorem (Kiefer and Wolfowitz 1960), which links D- and G-optimality. The theorem is phrased in terms of

  13. Chemicals-Based Formulation Design: Virtual Experimentations

    DEFF Research Database (Denmark)

    Conte, Elisa; Gani, Rafiqul

    2011-01-01

    This paper presents a systematic procedure for virtual experimentations related to the design of liquid formulated products. All the experiments that need to be performed when designing a liquid formulated product (lotion), such as ingredients selection and testing, solubility tests, property mea...... on the design of an insect repellent lotion will show that the software is an essential instrument in decision making, and that it reduces time and resources since experimental efforts can be focused on one or few product alternatives....

  14. Design of Uranium Solution Critical Experimental Device

    Institute of Scientific and Technical Information of China (English)

    YI; Da-yong; GUO; Zhi-jia; YAO; Cheng-zhi; SHI; Chen-lei

    2012-01-01

    <正>In 2012, Department of reactor engineering design completes the design and mechanical analysis of Uranium solution critical experimental device. According to user’s requirements and nuclear safety regulations, design and analysis mainly involves two sets of core structure, uranium solution loop, water loop and experimental bench, etc. The core which includes a core vessel, reactor core support, safety rods, control rods, and so on, is used for containing uranium solution and fuel element and fulfilling the

  15. An Introduction to Experimental Design Research

    DEFF Research Database (Denmark)

    2016-01-01

    Design research brings together influences from the whole gamut of social, psychological, and more technical sciences to create a tradition of empirical study stretching back over 50 years (Horvath 2004; Cross 2007). A growing part of this empirical tradition is experimental, which has gained...... in importance as the field has matured. As in other evolving disciplines, e.g. behavioural psychology, this maturation brings with it ever-greater scientific and methodological demands (Reiser 1939; Dorst 2008). In particular, the experimental paradigm holds distinct and significant challenges for the modern...... design researcher. Thus, this book brings together leading researchers from across design research in order to provide the reader with a foundation in experimental design research; an appreciation of possible experimental perspectives; and insight into how experiments can be used to build robust...

  16. Censored Weibull Distributed Data in Experimental Design

    OpenAIRE

    Støtvig, Jeanett Gunneklev

    2014-01-01

    Give an introduction to experimental design. Investigate how four methods handle Weibull distributed censored data, where the four methods are the quick and dirty method, the maximum likelihood method, single imputation and multiple imputation.

  17. Experimental design of a waste glass study

    Energy Technology Data Exchange (ETDEWEB)

    Piepel, G.F.; Redgate, P.E.; Hrma, P.

    1995-04-01

    A Composition Variation Study (CVS) is being performed to support a future high-level waste glass plant at Hanford. A total of 147 glasses, covering a broad region of compositions melting at approximately 1150{degrees}C, were tested in five statistically designed experimental phases. This paper focuses on the goals, strategies, and techniques used in designing the five phases. The overall strategy was to investigate glass compositions on the boundary and interior of an experimental region defined by single- component, multiple-component, and property constraints. Statistical optimal experimental design techniques were used to cover various subregions of the experimental region in each phase. Empirical mixture models for glass properties (as functions of glass composition) from previous phases wee used in designing subsequent CVS phases.

  18. Chemical-Based Formulation Design: Virtual Experimentation

    DEFF Research Database (Denmark)

    Conte, Elisa; Gani, Rafiqul

    This paper presents a software, the virtual Product-Process Design laboratory (virtual PPD-lab) and the virtual experimental scenarios for design/verification of consumer oriented liquid formulated products where the software can be used. For example, the software can be employed for the design...... system engineering community, it is possible now to replace, at least, some of the experimental steps with efficient and validated model-based approaches. For example, the search space can be significantly reduced through computer-aided screenings of the active ingredient (AI), the solvent mixture......, the additives and/or their mixtures (formulations). Therefore, the experimental resources can focus on a few candidate product formulations to find the best product. The virtual PPD-lab allows various options for experimentations related to design and/or verification of the product. For example, the selection...

  19. Design4Society: morality and technology revisited

    NARCIS (Netherlands)

    Verbeek, P.P.C.C.

    2015-01-01

    The moral significance of technology has become a central theme in the ethics of technology: rather than being ethically neutral, technologies have an inherent moral dimension. How can designers deal with this moral dimension of the technologies they are developing? From the perspective of technolog

  20. New product development using experimental design

    OpenAIRE

    Zhang, Zhihai

    1998-01-01

    New product development is one of the most powerful but difficult activities in business. It is also a very important factor affecting final product quality. There are many techniques available for new product development. Experimental design is now regarded as one of the most significant techniques. In this article, we will discuss how to use the technique of experimental design in developing a new product - an extrusion press. In order to provide a better understanding of this specific proc...

  1. Considering RNAi experimental design in parasitic helminths.

    Science.gov (United States)

    Dalzell, Johnathan J; Warnock, Neil D; McVeigh, Paul; Marks, Nikki J; Mousley, Angela; Atkinson, Louise; Maule, Aaron G

    2012-04-01

    Almost a decade has passed since the first report of RNA interference (RNAi) in a parasitic helminth. Whilst much progress has been made with RNAi informing gene function studies in disparate nematode and flatworm parasites, substantial and seemingly prohibitive difficulties have been encountered in some species, hindering progress. An appraisal of current practices, trends and ideals of RNAi experimental design in parasitic helminths is both timely and necessary for a number of reasons: firstly, the increasing availability of parasitic helminth genome/transcriptome resources means there is a growing need for gene function tools such as RNAi; secondly, fundamental differences and unique challenges exist for parasite species which do not apply to model organisms; thirdly, the inherent variation in experimental design, and reported difficulties with reproducibility undermine confidence. Ideally, RNAi studies of gene function should adopt standardised experimental design to aid reproducibility, interpretation and comparative analyses. Although the huge variations in parasite biology and experimental endpoints make RNAi experimental design standardization difficult or impractical, we must strive to validate RNAi experimentation in helminth parasites. To aid this process we identify multiple approaches to RNAi experimental validation and highlight those which we deem to be critical for gene function studies in helminth parasites.

  2. Yakima Hatchery Experimental Design : Annual Progress Report.

    Energy Technology Data Exchange (ETDEWEB)

    Busack, Craig; Knudsen, Curtis; Marshall, Anne

    1991-08-01

    This progress report details the results and status of Washington Department of Fisheries' (WDF) pre-facility monitoring, research, and evaluation efforts, through May 1991, designed to support the development of an Experimental Design Plan (EDP) for the Yakima/Klickitat Fisheries Project (YKFP), previously termed the Yakima/Klickitat Production Project (YKPP or Y/KPP). This pre- facility work has been guided by planning efforts of various research and quality control teams of the project that are annually captured as revisions to the experimental design and pre-facility work plans. The current objective are as follows: to develop genetic monitoring and evaluation approach for the Y/KPP; to evaluate stock identification monitoring tools, approaches, and opportunities available to meet specific objectives of the experimental plan; and to evaluate adult and juvenile enumeration and sampling/collection capabilities in the Y/KPP necessary to measure experimental response variables.

  3. Experimental Study and Design of Balloon expandable Endovascular Stent Expansion

    Institute of Scientific and Technical Information of China (English)

    WANG Yue-xuan; YI Hong; NI Zhong-hua

    2005-01-01

    The application background and experimental research overview of medical endovascular stent are presented. Based on the analytical comparison of the current research achievements, the life cycle of medical endovascular stent is pointed out and the characteristics of stent expansion in the life cycle are emphasized on.The experimental scheme of in vitro stent expansion based on the machine vision technology in LabVIEW is presented. The selection and usage of the chosen component devices and design of measurement program for experiment are expatiated. A special drug-loading stent was expanded on the assembled platform of selected equipments and experimental results were analyzed. The experimental scheme presented in the paper provides powerful experimental support for the optimization of stent design and computer simulation of stent expansion by the finite element analysis.

  4. Optimal Bayesian Experimental Design for Combustion Kinetics

    KAUST Repository

    Huan, Xun

    2011-01-04

    Experimental diagnostics play an essential role in the development and refinement of chemical kinetic models, whether for the combustion of common complex hydrocarbons or of emerging alternative fuels. Questions of experimental design—e.g., which variables or species to interrogate, at what resolution and under what conditions—are extremely important in this context, particularly when experimental resources are limited. This paper attempts to answer such questions in a rigorous and systematic way. We propose a Bayesian framework for optimal experimental design with nonlinear simulation-based models. While the framework is broadly applicable, we use it to infer rate parameters in a combustion system with detailed kinetics. The framework introduces a utility function that reflects the expected information gain from a particular experiment. Straightforward evaluation (and maximization) of this utility function requires Monte Carlo sampling, which is infeasible with computationally intensive models. Instead, we construct a polynomial surrogate for the dependence of experimental observables on model parameters and design conditions, with the help of dimension-adaptive sparse quadrature. Results demonstrate the efficiency and accuracy of the surrogate, as well as the considerable effectiveness of the experimental design framework in choosing informative experimental conditions.

  5. Optimal experimental design strategies for detecting hormesis.

    Science.gov (United States)

    Dette, Holger; Pepelyshev, Andrey; Wong, Weng Kee

    2011-12-01

    Hormesis is a widely observed phenomenon in many branches of life sciences, ranging from toxicology studies to agronomy, with obvious public health and risk assessment implications. We address optimal experimental design strategies for determining the presence of hormesis in a controlled environment using the recently proposed Hunt-Bowman model. We propose alternative models that have an implicit hormetic threshold, discuss their advantages over current models, and construct and study properties of optimal designs for (i) estimating model parameters, (ii) estimating the threshold dose, and (iii) testing for the presence of hormesis. We also determine maximin optimal designs that maximize the minimum of the design efficiencies when we have multiple design criteria or there is model uncertainty where we have a few plausible models of interest. We apply these optimal design strategies to a teratology study and show that the proposed designs outperform the implemented design by a wide margin for many situations.

  6. Using experimental design to define boundary manikins.

    Science.gov (United States)

    Bertilsson, Erik; Högberg, Dan; Hanson, Lars

    2012-01-01

    When evaluating human-machine interaction it is central to consider anthropometric diversity to ensure intended accommodation levels. A well-known method is the use of boundary cases where manikins with extreme but likely measurement combinations are derived by mathematical treatment of anthropometric data. The supposition by that method is that the use of these manikins will facilitate accommodation of the expected part of the total, less extreme, population. In literature sources there are differences in how many and in what way these manikins should be defined. A similar field to the boundary case method is the use of experimental design in where relationships between affecting factors of a process is studied by a systematic approach. This paper examines the possibilities to adopt methodology used in experimental design to define a group of manikins. Different experimental designs were adopted to be used together with a confidence region and its axes. The result from the study shows that it is possible to adapt the methodology of experimental design when creating groups of manikins. The size of these groups of manikins depends heavily on the number of key measurements but also on the type of chosen experimental design.

  7. Designing Mobile Health Technology for Bipolar Disorder

    DEFF Research Database (Denmark)

    Bardram, JE; Frost, Mads; Szántó, Károly

    2013-01-01

    usefulness of the system was high. Based on this study, the paper discusses three HCI questions related to the design of personal health technologies; how to design for disease awareness and self-treatment, how to ensure adherence to personal health technologies, and the roles of different types...... of technology platforms....

  8. Experimental design in chromatography: a tutorial review.

    Science.gov (United States)

    Hibbert, D Brynn

    2012-12-01

    The ability of a chromatographic method to successful separate, identify and quantitate species is determined by many factors, many of which are in the control of the experimenter. When attempting to discover the important factors and then optimise a response by tuning these factors, experimental design (design of experiments, DoE) gives a powerful suite of statistical methodology. Advantages include modelling by empirical functions, not requiring detailed knowledge of the underlying physico-chemical properties of the system, a defined number of experiments to be performed, and available software to accomplish the task. Two uses of DoE in chromatography are for showing lack of significant effects in robustness studies for method validation, and for identifying significant factors and then optimising a response with respect to them in method development. Plackett-Burman designs are widely used in validation studies, and fractional factorial designs and their extensions such as central composite designs are the most popular optimisers. Box-Behnken and Doehlert designs are becoming more used as efficient alternatives. If it is not possible to practically realise values of the factors required by experimental designs, or if there is a constraint on the total number of experiments that can be done, then D-optimal designs can be very powerful. Examples of the use of DoE in chromatography are reviewed. Recommendations are given on how to report DoE studies in the literature.

  9. Emerging memory technologies design, architecture, and applications

    CERN Document Server

    2014-01-01

    This book explores the design implications of emerging, non-volatile memory (NVM) technologies on future computer memory hierarchy architecture designs. Since NVM technologies combine the speed of SRAM, the density of DRAM, and the non-volatility of Flash memory, they are very attractive as the basis for future universal memories. This book provides a holistic perspective on the topic, covering modeling, design, architecture and applications. The practical information included in this book will enable designers to exploit emerging memory technologies to improve significantly the performance/power/reliability of future, mainstream integrated circuits. • Provides a comprehensive reference on designing modern circuits with emerging, non-volatile memory technologies, such as MRAM and PCRAM; • Explores new design opportunities offered by emerging memory technologies, from a holistic perspective; • Describes topics in technology, modeling, architecture and applications; • Enables circuit designers to ex...

  10. Experimental Design and Power Calculation for RNA-seq Experiments.

    Science.gov (United States)

    Wu, Zhijin; Wu, Hao

    2016-01-01

    Power calculation is a critical component of RNA-seq experimental design. The flexibility of RNA-seq experiment and the wide dynamic range of transcription it measures make it an attractive technology for whole transcriptome analysis. These features, in addition to the high dimensionality of RNA-seq data, bring complexity in experimental design, making an analytical power calculation no longer realistic. In this chapter we review the major factors that influence the statistical power of detecting differential expression, and give examples of power assessment using the R package PROPER.

  11. Experimental design research approaches, perspectives, applications

    CERN Document Server

    Stanković, Tino; Štorga, Mario

    2016-01-01

    This book presents a new, multidisciplinary perspective on and paradigm for integrative experimental design research. It addresses various perspectives on methods, analysis and overall research approach, and how they can be synthesized to advance understanding of design. It explores the foundations of experimental approaches and their utility in this domain, and brings together analytical approaches to promote an integrated understanding. The book also investigates where these approaches lead to and how they link design research more fully with other disciplines (e.g. psychology, cognition, sociology, computer science, management). Above all, the book emphasizes the integrative nature of design research in terms of the methods, theories, and units of study—from the individual to the organizational level. Although this approach offers many advantages, it has inherently led to a situation in current research practice where methods are diverging and integration between individual, team and organizational under...

  12. Technology Enhanced Learning in Design and Technology Education

    Science.gov (United States)

    Page, Tom; Thorsteinsson, Gisli

    2007-01-01

    The focus of this literature review addresses the opportunities that new media can have for design and technology education at the university level. Advances in public and technology interaction has changed drastically with the impact of New Media and Information and Communication Technologies (ICTs). This research investigates the role of New…

  13. Sociomaterial-design bounding technologies in practice

    CERN Document Server

    Bjorn, Pernille

    2014-01-01

    Investigates theoretically and empirically what it means to design technological artefacts while embracing the large number of practices which practitioners engage with when handling technologies. The authors discusses the fields of design and sociomateriality through their shared interests towards the basic nature of work, collaboration, organization, technology, and human agency, striving to make the debates and concepts originating in each field accessible to each other, and thus moving sociomateriality closer to the practical concerns of design and providing a useful analytical toolbox to

  14. Optimal Experimental Design for Model Discrimination

    Science.gov (United States)

    Myung, Jay I.; Pitt, Mark A.

    2009-01-01

    Models of a psychological process can be difficult to discriminate experimentally because it is not easy to determine the values of the critical design variables (e.g., presentation schedule, stimulus structure) that will be most informative in differentiating them. Recent developments in sampling-based search methods in statistics make it…

  15. Design of 162 MHz RF Experimental Cavity

    Institute of Scientific and Technical Information of China (English)

    YIN; Zhi-guo; CAO; Xue-long; GUO; Juan-juan; JI; Bin; FU; Xiao-liang; WEI; Jun-yi

    2015-01-01

    In this paper,a 162MHz RF experimental cavity is designed to study the multipacting multiplier effect of the medium and the metal electrode and its relationship with the plate surface characteristics,and to find out the method for inhibiting multipacting multiplier effects.The

  16. New product development using experimental design

    NARCIS (Netherlands)

    Zhang, Zhihai

    1998-01-01

    New product development is one of the most powerful but difficult activities in business. It is also a very important factor affecting final product quality. There are many techniques available for new product development. Experimental design is now regarded as one of the most significant techniques

  17. A design process for creative technology

    NARCIS (Netherlands)

    Mader, Angelika; Eggink, Wouter

    2014-01-01

    Creative Technology is a new bachelor programme at the University of Twente. Goal of Creative Technology is to design products and applications that improve the quality of daily life in its manifold aspects, building on Information and Communication Technology (ICT). The application domains range fr

  18. Using Aerospace Technology To Design Orthopedic Implants

    Science.gov (United States)

    Saravanos, D. A.; Mraz, P. J.; Davy, D. T.

    1996-01-01

    Technology originally developed to optimize designs of composite-material aerospace structural components used to develop method for optimizing designs of orthopedic implants. Development effort focused on designing knee implants, long-term goal to develop method for optimizing designs of orthopedic implants in general.

  19. Teachers as designers of technology enhanced learning

    NARCIS (Netherlands)

    Kali, Yael; McKenney, Susan; Sagy, Ornit

    2013-01-01

    Kali, Y., McKenney, S., & Sagy, O. (2012, 2-6 July). Teachers as designers of technology enhanced learning. Presentation at the Teachers as Designers of Technology Enhanced Learning pre-conference workshop in conjunction with the ISLS annual meeting, Sydney, Australia.

  20. An Assistive Technology Design Framework for ADHD

    DEFF Research Database (Denmark)

    Sonne, Tobias; Marshall, Paul; Obel, Carsten;

    In this paper, we present a design framework for ADHD assistive technologies that aims to give researchers grounding in the background research on the condition, to provide a lingua franca, and to highlight potential research directions for HCI researchers within assistive technology. The design...... framework couples ADHD patient challenge areas to technological opportunities and it provides a set of practical design strategies for developing successful assistive technologies for people with ADHD. The framework is based on empirical studies, ADHD research, and related work on assistive technologies. We...... map existing assistive technologies and potential new research efforts to the framework concepts. This way we show how it is used to support and advance the research and development of novel assistive technologies for the ADHD domain....

  1. An Assistive Technology Design Framework for ADHD

    DEFF Research Database (Denmark)

    Sonne, Tobias; Marshall, Paul; Obel, Carsten

    2016-01-01

    In this paper, we present a design framework for ADHD assistive technologies that aims to give researchers grounding in the background research on the condition, to provide a lingua franca, and to highlight potential research directions for HCI researchers within assistive technology. The design...... framework couples ADHD patient challenge areas to technological opportunities and it provides a set of practical design strategies for developing successful assistive technologies for people with ADHD. The framework is based on empirical studies, ADHD research, and related work on assistive technologies. We...... map existing assistive technologies and potential new research efforts to the framework concepts. This way we show how it is used to support and advance the research and development of novel assistive technologies for the ADHD domain....

  2. The Personal Health Technology Design Space

    DEFF Research Database (Denmark)

    Bardram, Jakob Eyvind; Frost, Mads

    2016-01-01

    . To enable designers to make informed and well-articulated design decision, the authors propose a design space for personal health technologies. This space consists of 10 dimensions related to the design of data sampling strategies, visualization and feedback approaches, treatment models, and regulatory......Interest is increasing in personal health technologies that utilize mobile platforms for improved health and well-being. However, although a wide variety of these systems exist, each is designed quite differently and materializes many different and more or less explicit design assumptions...

  3. Design and experimental results for the S809 airfoil

    Energy Technology Data Exchange (ETDEWEB)

    Somers, D M [Airfoils, Inc., State College, PA (United States)

    1997-01-01

    A 21-percent-thick, laminar-flow airfoil, the S809, for horizontal-axis wind-turbine applications, has been designed and analyzed theoretically and verified experimentally in the low-turbulence wind tunnel of the Delft University of Technology Low Speed Laboratory, The Netherlands. The two primary objectives of restrained maximum lift, insensitive to roughness, and low profile drag have been achieved. The airfoil also exhibits a docile stall. Comparisons of the theoretical and experimental results show good agreement. Comparisons with other airfoils illustrate the restrained maximum lift coefficient as well as the lower profile-drag coefficients, thus confirming the achievement of the primary objectives.

  4. Involving students in experimental design: three approaches.

    Science.gov (United States)

    McNeal, A P; Silverthorn, D U; Stratton, D B

    1998-12-01

    Many faculty want to involve students more actively in laboratories and in experimental design. However, just "turning them loose in the lab" is time-consuming and can be frustrating for both students and faculty. We describe three different ways of providing structures for labs that require students to design their own experiments but guide the choices. One approach emphasizes invertebrate preparations and classic techniques that students can learn fairly easily. Students must read relevant primary literature and learn each technique in one week, and then design and carry out their own experiments in the next week. Another approach provides a "design framework" for the experiments so that all students are using the same technique and the same statistical comparisons, whereas their experimental questions differ widely. The third approach involves assigning the questions or problems but challenging students to design good protocols to answer these questions. In each case, there is a mixture of structure and freedom that works for the level of the students, the resources available, and our particular aims.

  5. Design and Experimental Implementation of Bipedal robot

    Directory of Open Access Journals (Sweden)

    Sreejith C

    2012-09-01

    Full Text Available Biped robots have better mobility than conventional wheeled robots, but they tend to tip over easily. To be able to walk stably in various environments, such as on rough terrain, up and down slopes, or in regions containing obstacles, it is necessary for the robot to adapt to the ground conditions with a foot motion, and maintain its stability with a torso motion. In this paper, we first formulate the design and walking pattern for a bipedal robot and then a kicking robot has been developed for experimental verification. Finally, the correlation between the design and the walking patterns is described through simulation studies, and the effectiveness of the proposed methods is confirmed by simulation examples and experimental results.

  6. Bioinspiration: applying mechanical design to experimental biology.

    Science.gov (United States)

    Flammang, Brooke E; Porter, Marianne E

    2011-07-01

    The production of bioinspired and biomimetic constructs has fostered much collaboration between biologists and engineers, although the extent of biological accuracy employed in the designs produced has not always been a priority. Even the exact definitions of "bioinspired" and "biomimetic" differ among biologists, engineers, and industrial designers, leading to confusion regarding the level of integration and replication of biological principles and physiology. By any name, biologically-inspired mechanical constructs have become an increasingly important research tool in experimental biology, offering the opportunity to focus research by creating model organisms that can be easily manipulated to fill a desired parameter space of structural and functional repertoires. Innovative researchers with both biological and engineering backgrounds have found ways to use bioinspired models to explore the biomechanics of organisms from all kingdoms to answer a variety of different questions. Bringing together these biologists and engineers will hopefully result in an open discourse of techniques and fruitful collaborations for experimental and industrial endeavors.

  7. Fundamentals of statistical experimental design and analysis

    CERN Document Server

    Easterling, Robert G

    2015-01-01

    Professionals in all areas - business; government; the physical, life, and social sciences; engineering; medicine, etc. - benefit from using statistical experimental design to better understand their worlds and then use that understanding to improve the products, processes, and programs they are responsible for. This book aims to provide the practitioners of tomorrow with a memorable, easy to read, engaging guide to statistics and experimental design. This book uses examples, drawn from a variety of established texts, and embeds them in a business or scientific context, seasoned with a dash of humor, to emphasize the issues and ideas that led to the experiment and the what-do-we-do-next? steps after the experiment. Graphical data displays are emphasized as means of discovery and communication and formulas are minimized, with a focus on interpreting the results that software produce. The role of subject-matter knowledge, and passion, is also illustrated. The examples do not require specialized knowledge, and t...

  8. Designing interactive technology for crowd experiences - beyond sanitization

    DEFF Research Database (Denmark)

    Veerasawmy, Rune

    2014-01-01

    experience within interaction design. This dissertation introduces an understanding of crowd experience as a distinct type of social experiences driven by non-rational behavior. This conceptual understanding is established in the intersection between sociological crowd theory and a pragmatist perspective...... sanitization. The domain of my experimental design inquiries is at sporting events. From extensive theoretical studies and my empirical explorations I present a perspective on modern and professionalized sporting events as sanitized, where the spectator experiences and technology are being produced, controlled......This dissertation concerns the topic on designing interactive technology for crowd expe- riences. It takes the outset in the experience-oriented design approach within interaction design, exploring the research question how can we conceptually understand and design interactive technology for crowd...

  9. Optimal experimental design strategies for detecting hormesis

    OpenAIRE

    2010-01-01

    Hormesis is a widely observed phenomenon in many branches of life sciences ranging from toxicology studies to agronomy with obvious public health and risk assessment implications. We address optimal experimental design strategies for determining the presence of hormesis in a controlled environment using the recently proposed Hunt-Bowman model. We propose alternative models that have an implicit hormetic threshold, discuss their advantages over current models, construct and study properties of...

  10. Sequential experimental design based generalised ANOVA

    Energy Technology Data Exchange (ETDEWEB)

    Chakraborty, Souvik, E-mail: csouvik41@gmail.com; Chowdhury, Rajib, E-mail: rajibfce@iitr.ac.in

    2016-07-15

    Over the last decade, surrogate modelling technique has gained wide popularity in the field of uncertainty quantification, optimization, model exploration and sensitivity analysis. This approach relies on experimental design to generate training points and regression/interpolation for generating the surrogate. In this work, it is argued that conventional experimental design may render a surrogate model inefficient. In order to address this issue, this paper presents a novel distribution adaptive sequential experimental design (DA-SED). The proposed DA-SED has been coupled with a variant of generalised analysis of variance (G-ANOVA), developed by representing the component function using the generalised polynomial chaos expansion. Moreover, generalised analytical expressions for calculating the first two statistical moments of the response, which are utilized in predicting the probability of failure, have also been developed. The proposed approach has been utilized in predicting probability of failure of three structural mechanics problems. It is observed that the proposed approach yields accurate and computationally efficient estimate of the failure probability.

  11. Sequential experimental design based generalised ANOVA

    Science.gov (United States)

    Chakraborty, Souvik; Chowdhury, Rajib

    2016-07-01

    Over the last decade, surrogate modelling technique has gained wide popularity in the field of uncertainty quantification, optimization, model exploration and sensitivity analysis. This approach relies on experimental design to generate training points and regression/interpolation for generating the surrogate. In this work, it is argued that conventional experimental design may render a surrogate model inefficient. In order to address this issue, this paper presents a novel distribution adaptive sequential experimental design (DA-SED). The proposed DA-SED has been coupled with a variant of generalised analysis of variance (G-ANOVA), developed by representing the component function using the generalised polynomial chaos expansion. Moreover, generalised analytical expressions for calculating the first two statistical moments of the response, which are utilized in predicting the probability of failure, have also been developed. The proposed approach has been utilized in predicting probability of failure of three structural mechanics problems. It is observed that the proposed approach yields accurate and computationally efficient estimate of the failure probability.

  12. Designing Interactive Technology for Teens

    DEFF Research Database (Denmark)

    Read, Janet; Iversen, Ole Sejer; Horton, Matthew

    2012-01-01

    This half-day workshop builds upon previous work by the authors in understanding and designing for teenagers where the initial concern was to understand cool. Expanding out from this work, the workshop proposers now seek to better understand all the activities around designing for teenagers – the...

  13. Biomedical Optical Imaging Technologies Design and Applications

    CERN Document Server

    2013-01-01

    This book provides an introduction to design of biomedical optical imaging technologies and their applications. The main topics include: fluorescence imaging, confocal imaging, micro-endoscope, polarization imaging, hyperspectral imaging, OCT imaging, multimodal imaging and spectroscopic systems. Each chapter is written by the world leaders of the respective fields, and will cover: principles and limitations of optical imaging technology, system design and practical implementation for one or two specific applications, including design guidelines, system configuration, optical design, component requirements and selection, system optimization and design examples, recent advances and applications in biomedical researches and clinical imaging. This book serves as a reference for students and researchers in optics and biomedical engineering.

  14. Inclusive Design for Assistive Technology

    DEFF Research Database (Denmark)

    Herriott, Richard

    2014-01-01

    base. However, the conditions under which mainstream ID operates are not the same as those for AT. The scale of projects is smaller as tend to be the organisations that do such work. The models for ID design processes are designed for commercially-driven, medium-to-large scale concerns. This raises...... a wheelchair for children, a washbasin system, a rollator and breathing apparatus for patients with chronic obstructive pulmonary disorder. The interviews conducted showed that there was required a different emphasis in the means by which users´ requirements were incorporated into the design process...

  15. Designing Interactive Technology for Teens

    DEFF Research Database (Denmark)

    Read, Janet; Iversen, Ole Sejer; Horton, Matthew;

    2012-01-01

    This half-day workshop builds upon previous work by the authors in understanding and designing for teenagers where the initial concern was to understand cool. Expanding out from this work, the workshop proposers now seek to better understand all the activities around designing for teenagers – the...... space around teenagers whilst also distilling the similarities and differences in terms of similar approaches for children and adults....

  16. Designing Work, Technology, Organizations and Vice Versa

    DEFF Research Database (Denmark)

    link work and organisation to the use of artefacts and technological systems (and vice versa), exploring by means of different cases of organizational and design research articulations and disarticulations of daily work and design; the doing of objects and technologies in everyday organizational life...... of design has been ‘black-boxed’ and easily implied as an updated (and more fashionable) version of the traditional idea of structuring organizational processes. At the same time, working and organizing seem to be embedded nowadays in increasingly complex and situated technologies and practices....... If the spreading of information and communication technologies (ICTs) has changed workplaces (and even the very meaning of 'workplace' as an area marked by the physical presence of different human actors), working and organizing mobilizes the joint action of humans, technologies and knowledges. The aim of the book...

  17. An Ethical Framework for Evaluating Experimental Technology.

    Science.gov (United States)

    van de Poel, Ibo

    2016-06-01

    How are we to appraise new technological developments that may bring revolutionary social changes? Currently this is often done by trying to predict or anticipate social consequences and to use these as a basis for moral and regulatory appraisal. Such an approach can, however, not deal with the uncertainties and unknowns that are inherent in social changes induced by technological development. An alternative approach is proposed that conceives of the introduction of new technologies into society as a social experiment. An ethical framework for the acceptability of such experiments is developed based on the bioethical principles for experiments with human subjects: non-maleficence, beneficence, respect for autonomy, and justice. This provides a handle for the moral and regulatory assessment of new technologies and their impact on society.

  18. The Design of Large Technological Systems

    DEFF Research Database (Denmark)

    Pineda, Andres Felipe Valderrama

    This is a study of the processes of design of large technological systems based on a two-case study: the rapid transit bus system, Transmilenio, in Bogotá, Colombia, and the urban rail system, Metro, in Copenhagen, Denmark. The research focused especially on the process by which designers define...... material scripts during the conception, construction, implementation and operation of large technological systems. The main argument is that designers define scripts in a process in which three parallel developments are at play: first, a reading takes place of the history (past, present, future...... dynamics involved in the design processes of large technological systems by revealing how their constitution produces a reconfiguration of the arena of development of urban transport. This dynamic substantiates the co-evolution of technological systems and the city....

  19. Teacher Design Knowledge for Technology Enhanced Learning

    NARCIS (Netherlands)

    McKenney-Jensh, Susan E.

    2014-01-01

    This presentation shares a framework for investigating the knowledge teachers need to be able to design technology-enhanced learning. Specific activities are undertaken to consider elements within the framework

  20. Experimental design of laminar proportional amplifiers

    Science.gov (United States)

    Hellbaum, R. F.

    1976-01-01

    An experimental program was initiated at Langley Research Center to study the effects of various parameters on the design of laminar proportional beam deflection amplifiers. Matching and staging of amplifiers to obtain high-pressure gain was also studied. Variable parameters were aspect ratio, setback, control length, receiver distance, receiver width, width of center vent, and bias pressure levels. Usable pressure gains from 4 to 19 per stage can now be achieved, and five amplifiers were staged together to yield pressure gains up to 2,000,000.

  1. Designing Corporate Databases to Support Technology Innovation

    Science.gov (United States)

    Gultz, Michael Jarett

    2012-01-01

    Based on a review of the existing literature on database design, this study proposed a unified database model to support corporate technology innovation. This study assessed potential support for the model based on the opinions of 200 technology industry executives, including Chief Information Officers, Chief Knowledge Officers and Chief Learning…

  2. From Assigning to Designing Technological Agency

    NARCIS (Netherlands)

    Waelbers, Katinka

    2009-01-01

    In What Things Do, Verbeek (What things do: philosophical reflections on technology, agency and design. Penn State University Press, University Park, 2005a) develops a vocabulary for understanding the social role of technological artifacts in our culture and in our daily lives. He understands this r

  3. Design Technology for Heterogeneous Embedded Systems

    CERN Document Server

    O'Connor, Ian; Piguet, Christian

    2012-01-01

    Designing technology to address the problem of heterogeneous embedded systems, while remaining compatible with standard “More Moore” flows, i.e. capable of handling simultaneously both silicon complexity and system complexity, represents one of the most important challenges facing the semiconductor industry today. While the micro-electronics industry has built its own specific design methods to focus mainly on the management of complexity through the establishment of abstraction levels, the emergence of device heterogeneity requires new approaches enabling the satisfactory design of physically heterogeneous embedded systems for the widespread deployment of such systems. This book, compiled largely from a set of contributions from participants of past editions of the Winter School on Heterogeneous Embedded Systems Design Technology (FETCH), proposes a broad and holistic overview of design techniques used to tackle the various facets of heterogeneity in terms of technology and opportunities at the physical ...

  4. Set membership experimental design for biological systems

    Directory of Open Access Journals (Sweden)

    Marvel Skylar W

    2012-03-01

    Full Text Available Abstract Background Experimental design approaches for biological systems are needed to help conserve the limited resources that are allocated for performing experiments. The assumptions used when assigning probability density functions to characterize uncertainty in biological systems are unwarranted when only a small number of measurements can be obtained. In these situations, the uncertainty in biological systems is more appropriately characterized in a bounded-error context. Additionally, effort must be made to improve the connection between modelers and experimentalists by relating design metrics to biologically relevant information. Bounded-error experimental design approaches that can assess the impact of additional measurements on model uncertainty are needed to identify the most appropriate balance between the collection of data and the availability of resources. Results In this work we develop a bounded-error experimental design framework for nonlinear continuous-time systems when few data measurements are available. This approach leverages many of the recent advances in bounded-error parameter and state estimation methods that use interval analysis to generate parameter sets and state bounds consistent with uncertain data measurements. We devise a novel approach using set-based uncertainty propagation to estimate measurement ranges at candidate time points. We then use these estimated measurements at the candidate time points to evaluate which candidate measurements furthest reduce model uncertainty. A method for quickly combining multiple candidate time points is presented and allows for determining the effect of adding multiple measurements. Biologically relevant metrics are developed and used to predict when new data measurements should be acquired, which system components should be measured and how many additional measurements should be obtained. Conclusions The practicability of our approach is illustrated with a case study. This

  5. Set membership experimental design for biological systems

    Science.gov (United States)

    2012-01-01

    Background Experimental design approaches for biological systems are needed to help conserve the limited resources that are allocated for performing experiments. The assumptions used when assigning probability density functions to characterize uncertainty in biological systems are unwarranted when only a small number of measurements can be obtained. In these situations, the uncertainty in biological systems is more appropriately characterized in a bounded-error context. Additionally, effort must be made to improve the connection between modelers and experimentalists by relating design metrics to biologically relevant information. Bounded-error experimental design approaches that can assess the impact of additional measurements on model uncertainty are needed to identify the most appropriate balance between the collection of data and the availability of resources. Results In this work we develop a bounded-error experimental design framework for nonlinear continuous-time systems when few data measurements are available. This approach leverages many of the recent advances in bounded-error parameter and state estimation methods that use interval analysis to generate parameter sets and state bounds consistent with uncertain data measurements. We devise a novel approach using set-based uncertainty propagation to estimate measurement ranges at candidate time points. We then use these estimated measurements at the candidate time points to evaluate which candidate measurements furthest reduce model uncertainty. A method for quickly combining multiple candidate time points is presented and allows for determining the effect of adding multiple measurements. Biologically relevant metrics are developed and used to predict when new data measurements should be acquired, which system components should be measured and how many additional measurements should be obtained. Conclusions The practicability of our approach is illustrated with a case study. This study shows that our

  6. An Ethical Framework for Evaluating Experimental Technology

    NARCIS (Netherlands)

    Van de Poel, I.R.

    2015-01-01

    How are we to appraise new technological developments that may bring revolutionary social changes? Currently this is often done by trying to predict or anticipate social consequences and to use these as a basis for moral and regulatory appraisal. Such an approach can, however, not deal with the unce

  7. Mastering Technologies in Design-Driven Innovation

    DEFF Research Database (Denmark)

    Dell'era, Claudio; Marchesi, Alessio; Verganti, Roberto

    2010-01-01

    and semantic dimensions of a product. Case studies of two leading Italian companies in the furniture industry--Kartell and Luceplan--illustrate two principal interpretations of the role of technology in radical design-driven innovation: technology as an enabler of new product meanings for the customer......Only a few companies have mastered the design-driven approach to innovation. This paper examines what it means to make design a central part of the business process, able to add value to products and create new markets. More specifically, it focuses on the interplay between the functional......, and the importance of supply networks that allow manufacturers to change product technologies quickly and experiment with new technologies....

  8. Nanocluster technologies for electronics design

    CERN Document Server

    Parker, A J

    2001-01-01

    based electronic systems. The work presented in this thesis covers an investigation into the use of metal nanoclusters in nanoelectronics design. Initial studies explored the interactions of the dodecanethiol passivated gold nanocluster, held in solution with toluene, and the native oxide covered silicon surface. Deposition of the clusters is achieved by pippetting mu-litre quantities of the solution onto the surface, and allowing the solvent to evaporate leaving the clusters as residue. Patterning of the surface with micron scale photoresist structures prior to cluster exposure, led to the selective aggregation of cluster deposits along the resist boundaries. An extension of this technique, examined the flow of the cluster solution along photoresist structures which extended beyond the solution droplet. Investigation into the electronic properties of nanocluster arrays generated non-linear current-voltage curves, which are explained in terms of two very simple models. These results cast doubt over the suitab...

  9. Mill Designed Bio bleaching Technologies

    Energy Technology Data Exchange (ETDEWEB)

    Institute of Paper Science Technology

    2004-01-30

    A key finding of this research program was that Laccase Mediator Systems (LMS) treatments on high-kappa kraft could be successfully accomplished providing substantial delignification (i.e., > 50%) without detrimental impact on viscosity and significantly improved yield properties. The efficiency of the LMS was evident since most of the lignin from the pulp was removed in less than one hour at 45 degrees C. Of the mediators investigated, violuric acid was the most effective vis-a-vis delignification. A comparative study between oxygen delignification and violuric acid revealed that under relatively mild conditions, a single or a double LMS{sub VA} treatment is comparable to a single or a double O stage. Of great notability was the retention of end viscosity of LMS{sub VA} treated pulps with respect to the end viscosity of oxygen treated pulps. These pulps could then be bleached to full brightness values employing conventional ECF bleaching technologies and the final pulp physical properties were equal and/or better than those bleached in a conventional ECF manner employing an aggressively O or OO stage initially. Spectral analyses of residual lignins isolated after LMS treated high-kappa kraft pulps revealed that similar to HBT, VA and NHA preferentially attack phenolic lignin moieties. In addition, a substantial decrease in aliphatic hydroxyl groups was also noted, suggesting side chain oxidation. In all cases, an increase in carboxylic acid was observed. Of notable importance was the different selectivity of NHA, VA and HBT towards lignin functional groups, despite the common N-OH moiety. C-5 condensed phenolic lignin groups were overall resistant to an LMS{sub NHA, HBT} treatments but to a lesser extent to an LMS{sub VA}. The inactiveness of these condensed lignin moieties was not observed when low-kappa kraft pulps were biobleached, suggesting that the LMS chemistry is influenced by the extent of delignification. We have also demonstrated that the current

  10. Teachers as designers of technology enhanced learning

    NARCIS (Netherlands)

    Kali, Yael; McKenney, Susan; Sagy, Ornit; Voogt, Joke

    2015-01-01

    Design of (technology-enhanced) learning activities and materials is one fruitful process through which teachers learn and become professionals. To facilitate this process, research is needed to understand how teachers learn through design, how this process may be supported, and how teacher involvem

  11. Teachers as designers of technology enhanced learning

    NARCIS (Netherlands)

    Kali, Yael; McKenney, Susan; Sagy, Ornit; Voogt, Joke

    2015-01-01

    Design of (technology-enhanced) learning activities and materials is one fruitful process through which teachers learn and become professionals. To facilitate this process, research is needed to understand how teachers learn through design, how this process may be supported, and how teacher involvem

  12. Internet MEMS design tools based on component technology

    Science.gov (United States)

    Brueck, Rainer; Schumer, Christian

    1999-03-01

    The micro electromechanical systems (MEMS) industry in Europe is characterized by small and medium sized enterprises specialized on products to solve problems in specific domains like medicine, automotive sensor technology, etc. In this field of business the technology driven design approach known from micro electronics is not appropriate. Instead each design problem aims at its own, specific technology to be used for the solution. The variety of technologies at hand, like Si-surface, Si-bulk, LIGA, laser, precision engineering requires a huge set of different design tools to be available. No single SME can afford to hold licenses for all these tools. This calls for a new and flexible way of designing, implementing and distributing design software. The Internet provides a flexible manner of offering software access along with methodologies of flexible licensing e.g. on a pay-per-use basis. New communication technologies like ADSL, TV cable of satellites as carriers promise to offer a bandwidth sufficient even for interactive tools with graphical interfaces in the near future. INTERLIDO is an experimental tool suite for process specification and layout verification for lithography based MEMS technologies to be accessed via the Internet. The first version provides a Java implementation even including a graphical editor for process specification. Currently, a new version is brought into operation that is based on JavaBeans component technology. JavaBeans offers the possibility to realize independent interactive design assistants, like a design rule checking assistants, a process consistency checking assistants, a technology definition assistants, a graphical editor assistants, etc. that may reside distributed over the Internet, communicating via Internet protocols. Each potential user thus is able to configure his own dedicated version of a design tool set dedicated to the requirements of the current problem to be solved.

  13. Experimental design methodology: the scientific tool for performance evaluation

    Science.gov (United States)

    Sadjadi, Firooz A.

    1990-09-01

    With the rapid growth of the signal and image processing technology in the last several decades has arisen the need for means of evaluating and comparing the numerous algorithms and systems that are created or are being developed. Performance evaluation, in the past, has been mostly ad hoc and incohesive. In this paper we present a systematic step by step approach for the scientific evaluation of signal and image processing algorithms and systems. This approach is based on the methodology of Experimental Design. We illustrate this method by means of an example from the field of automatic object recognition.

  14. The role of experimental typography in designing logotypes

    OpenAIRE

    Pogačnik, Tadeja

    2014-01-01

    Designing logotypes is an important part of graphic design. Great logotypes are designed using custom made typefaces. Therefore, it is very important, especially for the typographic designer, to have practical experience and be up to date with all trends in the field of experimental typefaces design, also called experimental typography. In my thesis statement, I carefully examined the problems of experimental typography - which allows more creative and free typography designing for different ...

  15. Palmela points: technological processes and experimentation

    Directory of Open Access Journals (Sweden)

    Gutiérrez Sáez, Carmen

    2010-12-01

    Full Text Available The function of palmela points has generated a certain confusion, being interpreted as the tips of a lance, javelin and of an arrow or exclusively as elements of prestige. The aim of this work is to present the results of experimentation on a prey with 36 palmela arrowheads of copper and low tin-bronze, in tests of distance and also of ballistics. It is a question of determining also the function from the archaeological contexts where these pieces appear. The results throw light on the possible utilization of these objects as effective weapon.

    La lectura funcional de las puntas de palmela ha generado cierta confusión. Se han interpretado como elementos de lanza, jabalina y flecha o exclusivamente como objetos de prestigio. Presentamos un trabajo experimental donde se evalúa la viabilidad de estas puntas en los tres tipos de armas. La colección incluye 36 puntas de palmela de cobre y bronce bajo en estaño, utilizadas sobre una presa, en pruebas de distancia y balística. Se trata también de determinar la función a partir de los contextos arqueológicos donde aparecen estas piezas. Los resultados arrojan luz sobre la posible utilización de estos objetos como armas eficaces.

  16. Open Source Radiation Hardened by Design Technology

    Science.gov (United States)

    Shuler, Robert

    2016-01-01

    The proposed technology allows use of the latest microcircuit technology with lowest power and fastest speed, with minimal delay and engineering costs, through new Radiation Hardened by Design (RHBD) techniques that do not require extensive process characterization, technique evaluation and re-design at each Moore's Law generation. The separation of critical node groups is explicitly parameterized so it can be increased as microcircuit technologies shrink. The technology will be open access to radiation tolerant circuit vendors. INNOVATION: This technology would enhance computation intensive applications such as autonomy, robotics, advanced sensor and tracking processes, as well as low power applications such as wireless sensor networks. OUTCOME / RESULTS: 1) Simulation analysis indicates feasibility. 2)Compact voting latch 65 nanometer test chip designed and submitted for fabrication -7/2016. INFUSION FOR SPACE / EARTH: This technology may be used in any digital integrated circuit in which a high level of resistance to Single Event Upsets is desired, and has the greatest benefit outside low earth orbit where cosmic rays are numerous.

  17. Open Technology Approaches to Geospatial Interface Design

    Science.gov (United States)

    Crevensten, B.; Simmons, D.; Alaska Satellite Facility

    2011-12-01

    What problems do you not want your software developers to be solving? Choosing open technologies across the entire stack of software development-from low-level shared libraries to high-level user interaction implementations-is a way to help ensure that customized software yields innovative and valuable tools for Earth Scientists. This demonstration will review developments in web application technologies and the recurring patterns of interaction design regarding exploration and discovery of geospatial data through the Vertex: ASF's Dataportal interface, a project utilizing current open web application standards and technologies including HTML5, jQueryUI, Backbone.js and the Jasmine unit testing framework.

  18. Technologies and Designs for Electronic Nanocomputers

    Science.gov (United States)

    Montemerlo, Michael S.; Love, J. Christopher; Opiteck, Gregory J.; Goldhaber, David J.; Ellenbogen, James C.

    1995-01-01

    Diverse space-related applications have been proposed for microscopic and sub-microscopic structures, mechanisms, and 'organisms'. To govern their functions, many of these tiny systems will require even smaller, nanometer-scale programmable computers, i.e. 'nanocomputers' on-board. This paper provides an overview of the results of a nearly two-year study of the technologies and designs that presently are in development for electronic nanocomputers. Strengths and weaknesses of the various technologies and designs are discussed, as well as promising directions for remedying some of the present research issues in this area. The presentation is a synopsis of a longer MITRE review article on the same subject.

  19. Computational Design and Experimental Validation of New Thermal Barrier Systems

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Shengmin; Yang, Shizhong; Khosravi, Ebrahim

    2014-04-01

    This project (10/01/2010-9/30/2014), “Computational Design and Experimental Validation of New Thermal Barrier Systems”, originates from Louisiana State University (LSU) Mechanical Engineering Department and Southern University (SU) Department of Computer Science. This project will directly support the technical goals specified in DE-FOA-0000248, Topic Area 3: Turbine Materials, by addressing key technologies needed to enable the development of advanced turbines and turbine-based systems that will operate safely and efficiently using coal-derived synthesis gases. In this project, the focus is to develop and implement novel molecular dynamics method to improve the efficiency of simulation on novel TBC materials; perform high performance computing (HPC) on complex TBC structures to screen the most promising TBC compositions; perform material characterizations and oxidation/corrosion tests; and demonstrate our new thermal barrier coating (TBC) systems experimentally under integrated gasification combined cycle (IGCC) environments.

  20. Computational Design and Experimental Validation of New Thermal Barrier Systems

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Shengmin; Yang, Shizhong; Khosravi, Ebrahim

    2012-10-01

    This project (10/01/2010-9/30/2013), “Computational Design and Experimental Validation of New Thermal Barrier Systems”, originates from Louisiana State University (LSU) Mechanical Engineering Department and Southern University (SU) Department of Computer Science. This project will directly support the technical goals specified in DEFOA- 0000248, Topic Area 3: Turbine Materials, by addressing key technologies needed to enable the development of advanced turbines and turbine-based systems that will operate safely and efficiently using coal-derived synthesis gases. We will develop and implement novel molecular dynamics method to improve the efficiency of simulation on novel TBC materials; perform high performance computing (HPC) on complex TBC structures to screen the most promising TBC compositions; perform material characterizations and oxidation/corrosion tests; and demonstrate our new thermal barrier coating (TBC) systems experimentally under integrated gasification combined cycle (IGCC) environments. The durability of the coating will be examined using the proposed Durability Test Rig.

  1. Computational Design and Experimental Validation of New Thermal Barrier Systems

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Shengmin; Yang, Shizhong; Khosravi, Ebrahim

    2014-04-01

    This project (10/01/2010-9/30/2014), “Computational Design and Experimental Validation of New Thermal Barrier Systems”, originates from Louisiana State University (LSU) Mechanical Engineering Department and Southern University (SU) Department of Computer Science. This project will directly support the technical goals specified in DE-FOA-0000248, Topic Area 3: Turbine Materials, by addressing key technologies needed to enable the development of advanced turbines and turbine-based systems that will operate safely and efficiently using coal-derived synthesis gases. In this project, the focus is to develop and implement novel molecular dynamics method to improve the efficiency of simulation on novel TBC materials; perform high performance computing (HPC) on complex TBC structures to screen the most promising TBC compositions; perform material characterizations and oxidation/corrosion tests; and demonstrate our new thermal barrier coating (TBC) systems experimentally under integrated gasification combined cycle (IGCC) environments.

  2. Integrated collaborative building design using Internet technology

    OpenAIRE

    Roshani, D.M.R.

    2005-01-01

    Communication between the parties in a project of an integrated collaborative engineering system has been the subject of active research for many years. The construction industry has a long tradition of collaborative working between the members of the construction team. At the design stage, this has traditionally been based on physical meetings between representatives of the principal design team members. To aid these meetings, the information and communication technologies that are currently...

  3. A range finding protocol to support design for transcriptomics experimentation: examples of in-vitro and in-vivo murine UV exposure

    NARCIS (Netherlands)

    Bruning, O.; Rodenburg, W.; van Oostrom, C.T.; Jonker, M.J.; de Jong, M.; Dekker, R.J.; Rauwerda, H.; Ensink, W.A.; de Vries, A.; Breit, T.M.

    2014-01-01

    In transcriptomics research, design for experimentation by carefully considering biological, technological, practical and statistical aspects is very important, because the experimental design space is essentially limitless. Usually, the ranges of variable biological parameters of the design space

  4. Manifold Regularized Experimental Design for Active Learning.

    Science.gov (United States)

    Zhang, Lining; Shum, Hubert P H; Shao, Ling

    2016-12-02

    Various machine learning and data mining tasks in classification require abundant data samples to be labeled for training. Conventional active learning methods aim at labeling the most informative samples for alleviating the labor of the user. Many previous studies in active learning select one sample after another in a greedy manner. However, this is not very effective because the classification models has to be retrained for each newly labeled sample. Moreover, many popular active learning approaches utilize the most uncertain samples by leveraging the classification hyperplane of the classifier, which is not appropriate since the classification hyperplane is inaccurate when the training data are small-sized. The problem of insufficient training data in real-world systems limits the potential applications of these approaches. This paper presents a novel method of active learning called manifold regularized experimental design (MRED), which can label multiple informative samples at one time for training. In addition, MRED gives an explicit geometric explanation for the selected samples to be labeled by the user. Different from existing active learning methods, our method avoids the intrinsic problems caused by insufficiently labeled samples in real-world applications. Various experiments on synthetic datasets, the Yale face database and the Corel image database have been carried out to show how MRED outperforms existing methods.

  5. Teaching creativity in a technological design context

    NARCIS (Netherlands)

    van Overveld, Kees; Ahn, René; Reymen, Isabelle; Ivashkov, Maxim

    2003-01-01

    We want to teach creativity techniques to prospective technological designers in a domainindependent way. To facilitate this, we adopt a format and nomenclature that is close to the terminology used by engineers. Central notions are concepts, attributes and values. A crucial role is played by, what

  6. Teaching creativity in a technological design context

    NARCIS (Netherlands)

    Overveld, van Kees; Ahn, René; Reymen, Isabelle; Ivashkov, Maxim

    2003-01-01

    We want to teach creativity techniques to prospective technological designers in a domainindependent way. To facilitate this, we adopt a format and nomenclature that is close to the terminology used by engineers. Central notions are concepts, attributes and values. A crucial role is played by, what

  7. Teachers as designers of technology enhanced learning

    NARCIS (Netherlands)

    Kali, Yael; McKenney, Susan

    2012-01-01

    Kali, Y., & McKenney, S. (2012). Teachers as designers of technology enhanced learning. In J. van Aalst, K. Thompson, M. J. Jacobson, & P. Reimann (Eds.), The future of learning: Proceedings of the 10th international conference of the learning sciences (Vol. 2, pp. 582-583). Sydney, NSW, Australia:

  8. RFIC and MMIC design and technology

    CERN Document Server

    Robertson, I D

    2001-01-01

    This book gives an in-depth account of GaAs, InP and SiGe, technologies and describes all the key techniques for the design of amplifiers,ranging from filters and data converters to image oscillators, mixers, switches, variable attenuators, phase shifters, integrated antennas and complete monolithic transceivers.

  9. Teaching Design of Emerging Embodied Technologies

    DEFF Research Database (Denmark)

    Majgaard, Gunver

    2014-01-01

    How does design of emerging embodied technologies enrich the HCI learning processes? We introduce a model for embodied interaction and use it in the development of a painting app for children, based on the motion sensor Asus Xtion Pro (similar to Kinect). The development of the app was part...

  10. Biometric systems technology, design and performance evaluation

    CERN Document Server

    Wayman, James; Maltoni, Davide

    2005-01-01

    A reference book for anyone involved in the design, management or implementation of biometric systems, and provides all the information needed to a build reliable system. It focuses on the four most widely used types of biometric technology - speech, fingerprint, iris and face recognition.

  11. Analytical and experimental study of freeform object design and simultaneous manufacturing

    Science.gov (United States)

    Zhang, Weihan; Zhang, Wei; Wang, Xiaofang; Yan, Jingbin

    2003-04-01

    Applications of Virtual Reality (VR) technology in many fields have gained great success. In the product development field, VR is a good tool to provide interactive and friendly human-machine interface. Freeform Object Design and Simultaneous Manufacturing (FODSM) uses VR to establish an interactive design environment and enable simultaneous manufacturing. It aims at improving design efficiency, creativity, ease of use, and also aims at integrating design and manufacturing in order to obtain the designed object by the designer independently and simultaneously. For the current stage, key technologies to implement FODSM include the algorithm of swept volume calculation and the following Boolean operation, mechanism to provide natural and intuitive feedback. This paper uses an analytical and experimental method to implement the novel design and manufacturing technology. Key issues are analyzed and tested. Experimental details are demonstrated.

  12. Engineering, Trade, and Technical Cluster. Task Analyses. Drafting and Design Technology, Precision Machining Technology, Electronics Technology.

    Science.gov (United States)

    Henrico County Public Schools, Glen Allen, VA. Virginia Vocational Curriculum and Resource Center.

    Developed in Virginia, this publication contains task analysis guides to support selected tech prep programs that prepare students for careers in the engineering, trade, and technical cluster. Three occupations are profiled: drafting and design technology, precision machining technology, and electronics technology. Each guide contains the…

  13. Autonomous entropy-based intelligent experimental design

    Science.gov (United States)

    Malakar, Nabin Kumar

    2011-07-01

    The aim of this thesis is to explore the application of probability and information theory in experimental design, and to do so in a way that combines what we know about inference and inquiry in a comprehensive and consistent manner. Present day scientific frontiers involve data collection at an ever-increasing rate. This requires that we find a way to collect the most relevant data in an automated fashion. By following the logic of the scientific method, we couple an inference engine with an inquiry engine to automate the iterative process of scientific learning. The inference engine involves Bayesian machine learning techniques to estimate model parameters based upon both prior information and previously collected data, while the inquiry engine implements data-driven exploration. By choosing an experiment whose distribution of expected results has the maximum entropy, the inquiry engine selects the experiment that maximizes the expected information gain. The coupled inference and inquiry engines constitute an autonomous learning method for scientific exploration. We apply it to a robotic arm to demonstrate the efficacy of the method. Optimizing inquiry involves searching for an experiment that promises, on average, to be maximally informative. If the set of potential experiments is described by many parameters, the search involves a high-dimensional entropy space. In such cases, a brute force search method will be slow and computationally expensive. We develop an entropy-based search algorithm, called nested entropy sampling, to select the most informative experiment. This helps to reduce the number of computations necessary to find the optimal experiment. We also extended the method of maximizing entropy, and developed a method of maximizing joint entropy so that it could be used as a principle of collaboration between two robots. This is a major achievement of this thesis, as it allows the information-based collaboration between two robotic units towards a same

  14. Designing Assistive Technologies for the ADHD Domain

    DEFF Research Database (Denmark)

    Sonne, Tobias; Grønbæk, Kaj

    (ADHD). In this paper, we identify a set of challenges that children with ADHD typically experience, which provides an empirical foundation for pervasive health researchers to address the ADHD domain. The work is grounded in extensive empirical studies and it is contextualized using literature on ADHD....... Based on these studies, we also present lessons learned that are relevant to consider when designing assistive technology to support children with ADHD. Finally, we provide an example (CASTT) of our own work to illustrate how the presented findings can frame research activities and be used to develop...... novel assistive technology to empower children with ADHD and improve their wellbeing....

  15. Web Based Learning Support for Experimental Design in Molecular Biology.

    Science.gov (United States)

    Wilmsen, Tinri; Bisseling, Ton; Hartog, Rob

    An important learning goal of a molecular biology curriculum is a certain proficiency level in experimental design. Currently students are confronted with experimental approaches in textbooks, in lectures and in the laboratory. However, most students do not reach a satisfactory level of competence in the design of experimental approaches. This…

  16. Biomimetics for architecture & design nature, analogies, technology

    CERN Document Server

    Pohl, Göran

    2015-01-01

    This book provides the readers with a timely guide to the application of biomimetic principles in architecture and engineering design. As a result of a combined effort by two internationally recognized authorities, the biologist Werner Nachtigall and the architect Göran Pohl, the book describes the principles which can be used to compare nature and technology, and at the same time it presents detailed explanations and examples showing how biology can be used as a source of inspiration and “translated” in building and architectural solutions (biomimicry). Even though nature cannot be directly copied, the living world can provide architects and engineers with a wealth of analogues and inspirations for their own creative designs. But how can analysis of natural entities give rise to advanced and sustainable design? By reporting on the latest bionic design methods and using extensive artwork, the book guides readers through the field of nature-inspired architecture, offering an extraordinary resource for pro...

  17. Technological Design in a multidisciplinary, sensory, context

    Directory of Open Access Journals (Sweden)

    Stephen Emmitt

    2011-11-01

    Full Text Available Architecture involves measurable (tangible and immeasurable (intangible elements, which makes the pursuit of good architecture a constant challenge for all project contributors. It is often the immeasurable aspects, the intuition and feel for a project and the way in which actors interact, which help to bring about exciting, creative and functional buildings that reflect the best of humanity, time and place. In this article the author explores the role of technological design within an environmentally responsible age. The narrative moves through the sustainable vernacular to the constructive link between design and construction, concluding with some reflections on the shape of things to come.

  18. Tabletop Games: Platforms, Experimental Games and Design Recommendations

    Science.gov (United States)

    Haller, Michael; Forlines, Clifton; Koeffel, Christina; Leitner, Jakob; Shen, Chia

    While the last decade has seen massive improvements in not only the rendering quality, but also the overall performance of console and desktop video games, these improvements have not necessarily led to a greater population of video game players. In addition to continuing these improvements, the video game industry is also constantly searching for new ways to convert non-players into dedicated gamers. Despite the growing popularity of computer-based video games, people still love to play traditional board games, such as Risk, Monopoly, and Trivial Pursuit. Both video and board games have their strengths and weaknesses, and an intriguing conclusion is to merge both worlds. We believe that a tabletop form-factor provides an ideal interface for digital board games. The design and implementation of tabletop games will be influenced by the hardware platforms, form factors, sensing technologies, as well as input techniques and devices that are available and chosen. This chapter is divided into three major sections. In the first section, we describe the most recent tabletop hardware technologies that have been used by tabletop researchers and practitioners. In the second section, we discuss a set of experimental tabletop games. The third section presents ten evaluation heuristics for tabletop game design.

  19. Development of the Biological Experimental Design Concept Inventory (BEDCI)

    OpenAIRE

    2014-01-01

    Interest in student conception of experimentation inspired the development of a fully validated 14-question inventory on experimental design in biology (BEDCI) by following established best practices in concept inventory (CI) design. This CI can be used to diagnose specific examples of non–expert-like thinking in students and to evaluate the success of teaching strategies that target conceptual changes. We used BEDCI to diagnose non–expert-like student thinking in experimental design at the p...

  20. Power Analysis Tutorial for Experimental Design Software

    Science.gov (United States)

    2014-11-01

    Details ............................................................ D-1 Appendix E – JMP Monte Carlo Simulation Script...freedom for error. • In Design Expert, when constructing a design, you are asked for delta and sigma . The default model for power analysis is...Designed Experiments. Third Edition. New York: John Wiley and Sons, 2009. 12. Muthen, Linda, and Bengt Muthen. “How to Use a Monte Carlo Study to

  1. Experimental design in analytical chemistry--part II: applications.

    Science.gov (United States)

    Ebrahimi-Najafabadi, Heshmatollah; Leardi, Riccardo; Jalali-Heravi, Mehdi

    2014-01-01

    This paper reviews the applications of experimental design to optimize some analytical chemistry techniques such as extraction, chromatography separation, capillary electrophoresis, spectroscopy, and electroanalytical methods.

  2. Conceptual design report, CEBAF basic experimental equipment

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1990-04-13

    The Continuous Electron Beam Accelerator Facility (CEBAF) will be dedicated to basic research in Nuclear Physics using electrons and photons as projectiles. The accelerator configuration allows three nearly continuous beams to be delivered simultaneously in three experimental halls, which will be equipped with complementary sets of instruments: Hall A--two high resolution magnetic spectrometers; Hall B--a large acceptance magnetic spectrometer; Hall C--a high-momentum, moderate resolution, magnetic spectrometer and a variety of more dedicated instruments. This report contains a short description of the initial complement of experimental equipment to be installed in each of the three halls.

  3. EBTS:DESIGN AND EXPERIMENTAL STUDY.

    Energy Technology Data Exchange (ETDEWEB)

    PIKIN,A.; ALESSI,J.; BEEBE,E.; KPONOU,A.; PRELEC,K.; KUZNETSOV,G.; TIUNOV,M.

    2000-11-06

    Experimental study of the BNL Electron Beam Test Stand (EBTS), which is a prototype of the Relativistic Heavy Ion Collider (RHIC) Electron Beam Ion Source (EBIS), is currently underway. The basic physics and engineering aspects of a high current EBIS implemented in EBTS are outlined and construction of its main systems is presented. Efficient transmission of a 10 A electron beam through the ion trap has been achieved. Experimental results on generation of multiply charged ions with both continuous gas and external ion injection confirm stable operation of the ion trap.

  4. Designing institutions for climate change: Why rational design involves technology

    Energy Technology Data Exchange (ETDEWEB)

    Coninck, H. de [Energy Research Centre of the Netherlands, Petten (Netherlands)

    2008-09-30

    This paper aims to explore how to augment the institutional solutions offered by current political theory for addressing the unprecedented problem of climate change. Although steering directly at emission reductions in an international treaty has benefits in terms of cost-effectiveness, the paper arrives at the conclusion that considerations around technological development should be drawn into the treaty equation in order to generate sufficient reciprocity to have a politically feasible international regime. It then argues that the benefits of technology agreements for climate change mitigation may be larger than commonly assumed, as they - if properly designed - could lead to real emission reductions and provide more flexibility to reach agreement in post-2012 negotiations than proposals modelled exclusively on the Kyoto Protocol or other types of absolute emission targets. Based on rational design of international institutions for environmental governance, and attempting to take into account considerations of technological dynamics and the 'sociotechnical system', contours of a possible environmentally effective and politically feasible international climate change agreements are sketched.

  5. Experimental Plans and Intensive Numerical Aided Design

    Directory of Open Access Journals (Sweden)

    Yvon Gardan

    2014-09-01

    Full Text Available This paper deals with new methods to optimize design and subsequent phases, notably in SMEs specialized in manufacturing. SMEs use numerical simulation to verify that the design meets the expectations of the specification, following the current traditional process: CAD model, simulation of its behavior, changes in the CAD model... This process suffers from a number of drawbacks: no overall multi-criteria vision, use of CAD software, by nature "constructive, not considering the overall objectives (even with integration of the parameters or with considering the downstream phases. The research centre DINCCS led several projects, relying on industrial cases to consider more efficient approaches. It is proposed to reverse this process by making intensive simulations, based on trade knowledge, before design itself. In order to plan the great number of simulations, automatically designed plan of experiences are used. We discuss the application of this approach to intensive simulations. The stakes are crucial for SMEs, particularly manufacturing ones. Using numerical simulation (optimization intensively, before setting the CAD model, they can get unexpected gains (mass, better use of the means of manufacture.... The results show that the proposed approach is a very promising new way of computer aided design..

  6. Teaching Experimental Design to Elementary School Pupils in Greece

    Science.gov (United States)

    Karampelas, Konstantinos

    2016-01-01

    This research is a study about the possibility to promote experimental design skills to elementary school pupils. Experimental design and the experiment process are foundational elements in current approaches to Science Teaching, as they provide learners with profound understanding about knowledge construction and science inquiry. The research was…

  7. The Implications of "Contamination" for Experimental Design in Education

    Science.gov (United States)

    Rhoads, Christopher H.

    2011-01-01

    Experimental designs that randomly assign entire clusters of individuals (e.g., schools and classrooms) to treatments are frequently advocated as a way of guarding against contamination of the estimated average causal effect of treatment. However, in the absence of contamination, experimental designs that randomly assign intact clusters to…

  8. Development of the Biological Experimental Design Concept Inventory (BEDCI)

    Science.gov (United States)

    Deane, Thomas; Nomme, Kathy; Jeffery, Erica; Pollock, Carol; Birol, Gulnur

    2014-01-01

    Interest in student conception of experimentation inspired the development of a fully validated 14-question inventory on experimental design in biology (BEDCI) by following established best practices in concept inventory (CI) design. This CI can be used to diagnose specific examples of non-expert-like thinking in students and to evaluate the…

  9. A framework for efficient process development using optimal experimental designs

    NARCIS (Netherlands)

    Ven, P. van de; Bijlsma, S.; Gout, E.; Voort Maarschalk, K. van der; Thissen, U.

    2011-01-01

    Introduction: The aim of this study was to develop and demonstrate a framework assuring efficient process development using fewer experiments than standard experimental designs. Methods: A novel optimality criterion for experimental designs (Iw criterion) is defined that leads to more efficient proc

  10. Wind turbine technology principles and design

    CERN Document Server

    Adaramola, Muyiwa

    2014-01-01

    IntroductionPart I: AerodynamicsWind Turbine Blade Design; Peter J. Schubel and Richard J. CrossleyA Shrouded Wind Turbine Generating High Output Power with Wind-Lens Technology; Yuji Ohya and Takashi KarasudaniEcomoulding of Composite Wind Turbine Blades Using Green Manufacturing RTM Process; Brahim AttafAerodynamic Shape Optimization of a Vertical-Axis Wind Turbine Using Differential Evolution; Travis J. Carrigan, Brian H. Dennis, Zhen X. Han, and Bo P. WangPart II: Generators and Gear Systems

  11. Research designs for experimental single-case studies

    Directory of Open Access Journals (Sweden)

    Ralf Spieß

    2012-09-01

    Full Text Available This overview describes the most important designs for single case experimental studies, which are ABAB-design, multiple baseline design, alternating treatments design and changing criterion design. The logic of experimental control in single case studies is explained and it is described, how these different designs are able to provide internal validity and enable causal interpretations of intervention outcome. An important precondition of valid interpretation is objective and reliable data assessment. Data evaluation by visual inspection is explained and several methods of statistical data analysis are discussed. To establish generability across persons, situations, and settings, the importance of replication studies is highlighted.

  12. Autism genetics: Methodological issues and experimental design.

    Science.gov (United States)

    Sacco, Roberto; Lintas, Carla; Persico, Antonio M

    2015-10-01

    Autism is a complex neuropsychiatric disorder of developmental origin, where multiple genetic and environmental factors likely interact resulting in a clinical continuum between "affected" and "unaffected" individuals in the general population. During the last two decades, relevant progress has been made in identifying chromosomal regions and genes in linkage or association with autism, but no single gene has emerged as a major cause of disease in a large number of patients. The purpose of this paper is to discuss specific methodological issues and experimental strategies in autism genetic research, based on fourteen years of experience in patient recruitment and association studies of autism spectrum disorder in Italy.

  13. Irradiation Design for an Experimental Murine Model

    Science.gov (United States)

    Ballesteros-Zebadúa, P.; Lárraga-Gutierrez, J. M.; García-Garduño, O. A.; Rubio-Osornio, M. C.; Custodio-Ramírez, V.; Moreno-Jimenez, S.; Suarez-Campos, J. E.; Paz, C.; Celis, M. A.

    2010-12-01

    In radiotherapy and stereotactic radiosurgery, small animal experimental models are frequently used, since there are still a lot of unsolved questions about the biological and biochemical effects of ionizing radiation. This work presents a method for small-animal brain radiotherapy compatible with a dedicated 6MV Linac. This rodent model is focused on the research of the inflammatory effects produced by ionizing radiation in the brain. In this work comparisons between Pencil Beam and Monte Carlo techniques, were used in order to evaluate accuracy of the calculated dose using a commercial planning system. Challenges in this murine model are discussed.

  14. Architectural quality: innovation, technological research and design

    Directory of Open Access Journals (Sweden)

    Andrea Campioli

    2011-04-01

    Full Text Available Architectural redevelopment and the revival of the construction sector are conditional on the incentivisation and bolstering of innovation processes. Thus the partial declensions that have been attached to these processes over the last few years have seen research and experimentation being tailored to the spectacularisation of shapes or the hidden performance optimisation of materials and components. Genuine improvement in the quality of architecture and its construction in this day and age depends on the abilities of designers to adopt the entire life cycle of buildings as a reference framework and on the willingness of all those working in the construction supply chain to activate virtuous cooperation.

  15. EXPERIMENTAL AND THEORETICAL FOUNDATIONS AND PRACTICAL IMPLEMENTATION OF TECHNOLOGY BRAIN-COMPUTER INTERFACE

    Directory of Open Access Journals (Sweden)

    A. Ya. Kaplan

    2013-01-01

    Full Text Available Technology brain-computer interface (BCI allow saperson to learn how to control external devices via thevoluntary regulation of own EEG directly from the brain without the involvement in the process of nerves and muscles. At the beginning the main goal of BCI was to replace or restore motor function to people disabled by neuromuscular disorders. Currently, the task of designing the BCI increased significantly, more capturing different aspects of life a healthy person. This article discusses the theoretical, experimental and technological base of BCI development and systematized critical fields of real implementation of these technologies.

  16. Computational Design and Experimental Validation of New Thermal Barrier Systems

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Shengmin; Yang, Shizhong; Khosravi, Ebrahim

    2011-12-31

    This project (10/01/2010-9/30/2013), “Computational Design and Experimental Validation of New Thermal Barrier Systems”, originates from Louisiana State University (LSU) Mechanical Engineering Department and Southern University (SU) Department of Computer Science. This proposal will directly support the technical goals specified in DE-FOA-0000248, Topic Area 3: Turbine Materials, by addressing key technologies needed to enable the development of advanced turbines and turbine-based systems that will operate safely and efficiently using coal-derived synthesis gases. We will develop novel molecular dynamics method to improve the efficiency of simulation on novel TBC materials; we will perform high performance computing (HPC) on complex TBC structures to screen the most promising TBC compositions; we will perform material characterizations and oxidation/corrosion tests; and we will demonstrate our new Thermal barrier coating (TBC) systems experimentally under Integrated gasification combined cycle (IGCC) environments. The durability of the coating will be examined using the proposed High Temperature/High Pressure Durability Test Rig under real syngas product compositions.

  17. Integrating Instructional Technology with Information Technology and Its Implications for Designing Electronic Learning Systems.

    Science.gov (United States)

    Abdelraheem, Ahmed Yousif

    2005-01-01

    In this paper the concepts of technology, instructional technology, and information technology are presented. The integration of instructional technology, and information technology is established and its implications for electronic learning systems design are discussed. One can say that: information and instructional designers can design…

  18. Building Design Guidelines for Solar Energy Technologies

    Science.gov (United States)

    Givoni, B.

    1989-01-01

    There are two main objectives to this publication. The first is to find out the communalities in the experience gained in previous studies and in actual applications of solar technologies in buildings, residential as well as nonresidential. The second objective is to review innovative concepts and products which may have an impact on future developments and applications of solar technologies in buildings. The available information and common lessons were collated and presented in a form which, hopefully, is useful for architects and solar engineers, as well as for teachers of "solar architecture" and students in Architectural Schools. The publication is based mainly on the collection and analysis of relevant information. The information included previous studies in which the performance of solar buildings was evaluated, as well as the personal experience of the Author and the research consultants. The state of the art, as indicated by these studies and personal experience, was summarized and has served as basis for the development of the Design Guidelines. In addition to the summary of the state of the art, as was already applied in solar buildings, an account was given of innovative concepts and products. Such innovations have occurred in the areas of thermal storage by Phase Change Materials (PCM) and in glazing with specialized or changeable properties. Interesting concepts were also developed for light transfer, which may enable to transfer sunlight to the core areas of large multi story nonresidential buildings. These innovations may have a significant impact on future developments of solar technologies and their applications in buildings.

  19. Essential Concepts of Engineering Design Curriculum in Secondary Technology Education

    Science.gov (United States)

    Wicklein, Robert; Smith, Phillip Cameron, Jr.; Kim, Soo Jung

    2009-01-01

    Technology education is a field of study that seeks to promote technological literacy for all students. Wright and Lauda defined technology education as a program designed to help students "develop an understanding and competence in designing, producing, and using technological products and systems, and in assessing the appropriateness of…

  20. Split-plot designs for multistage experimentation

    DEFF Research Database (Denmark)

    Kulahci, Murat; Tyssedal, John

    2016-01-01

    at the same time will be more efficient. However, there have been only a few attempts in the literature to provide an adequate and easy-to-use approach for this problem. In this paper, we present a novel methodology for constructing two-level split-plot and multistage experiments. The methodology is based...... be accommodated in each stage. Furthermore, split-plot designs for multistage experiments with good projective properties are also provided....

  1. Information measures in nonlinear experimental design

    Science.gov (United States)

    Niple, E.; Shaw, J. H.

    1980-01-01

    Some different approaches to the problem of designing experiments which estimate the parameters of nonlinear models are discussed. The assumption in these approaches that the information in a set of data can be represented by a scalar is criticized, and the nonscalar discrimination information is proposed as the proper measure to use. The two-step decay example in Box and Lucas (1959) is used to illustrate the main points of the discussion.

  2. Designing Pervasive Computing Technology - In a Nomadic Work Perspective

    DEFF Research Database (Denmark)

    Kristensen, Jannie Friis

    2002-01-01

    In my thesis work I am investigating how the design of pervasive/ubiquitous computing technology, relate to the flexible and individual work practice of nomadic workers. Through empirical studies and with an experimental systems development approach, the work is focused on: a) Supporting...... interpretation and inclusion of implicit and invisible as well as explicit and visible characteristics of artifacts, users and use practices. b) Identifying breakdowns in human-computer interaction situations, with particular emphasis on the computation that happens "behind the scenes" in the pervasive computing...... environment, and how that computational process at a sufficient level is made intelligible, visible, accountable and negotiable to the human participant....

  3. Experimental Charging Behavior of Orion UltraFlex Array Designs

    Science.gov (United States)

    Golofaro, Joel T.; Vayner, Boris V.; Hillard, Grover B.

    2010-01-01

    The present ground based investigations give the first definitive look describing the charging behavior of Orion UltraFlex arrays in both the Low Earth Orbital (LEO) and geosynchronous (GEO) environments. Note the LEO charging environment also applies to the International Space Station (ISS). The GEO charging environment includes the bounding case for all lunar mission environments. The UltraFlex photovoltaic array technology is targeted to become the sole power system for life support and on-orbit power for the manned Orion Crew Exploration Vehicle (CEV). The purpose of the experimental tests is to gain an understanding of the complex charging behavior to answer some of the basic performance and survivability issues to ascertain if a single UltraFlex array design will be able to cope with the projected worst case LEO and GEO charging environments. Stage 1 LEO plasma testing revealed that all four arrays successfully passed arc threshold bias tests down to -240 V. Stage 2 GEO electron gun charging tests revealed that only the front side area of indium tin oxide coated array designs successfully passed the arc frequency tests

  4. EXPERIMENTAL RESEARCH REGARDING LEATHER APPLICATIONS IN PRODUCT DESIGN

    Directory of Open Access Journals (Sweden)

    PRALEA Jeni

    2015-05-01

    Full Text Available This paper presents the role and importance of experimental research in design activity. The designer, as a researcher and a project manager, proposes to establish a relationship between functional-aesthetic-constructive-technological-economic,based on the aesthetic possibilities of the materials used for the experiments. With the aim to identify areas for the application of leather waste resulted from the production process, the paper presents experiments conducted with this material in combination with wood, by using different techniques that lead to different aesthetic effects. Identifying the areas to use and creating products from leather and/or wood waste, is based on the properties of these materials. Leather, the subject of these experiments, has the advantage that it can be used on both sides. Tactile differences of the two sides of this material has both aesthetical and functional advantages, which makes it suitable for applications on products that meet the requirements of "design for all". With differentiated tactile characteristics, in combination with other materials, for these experiments wood, easily "read touch" products can be generated to help people with certain disabilities. Thus, experiments presented in this paper allows the establishment of aesthetic schemes applicable to products that are friendly both with the environment (based on the reuse of wood and leather waste and with the users (can be used as applications, accessories and concepts of products for people with certain disabilities. The designer’s choices or decisions can be based on the results of this experiment. The experiment enables the designer to develop creative, innovative and environmentally friendly products.

  5. Human Factors Experimental Design and Analysis Reference

    Science.gov (United States)

    2007-07-01

    1) • Box Correction for Repeated Measures (Box, 1954) – Adjusted F Table – F[(k-1)ε, (n-1)(k-1)ε] – Imhof (1962) Table for Small Sample Size (nɡ...1954) provided an adjusted F tabled value based on the value of ε as shown in the middle of this slide. Alternatively, the Imhof (1962) Table is...freedom from sample data in randomized block and split-plot designs. Journal of Educational Statistics, 1, 69-82. Imhof , J.P. (1962). Testing the

  6. Design and Experimental Implementation of Bipedal robot

    OpenAIRE

    Sreejith C; Sreeshma K

    2012-01-01

    Biped robots have better mobility than conventional wheeled robots, but they tend to tip over easily. To be able to walk stably in various environments, such as on rough terrain, up and down slopes, or in regions containing obstacles, it is necessary for the robot to adapt to the ground conditions with a foot motion, and maintain its stability with a torso motion. In this paper, we first formulate the design and walking pattern for a bipedal robot and then a kicking robot has been developed f...

  7. On experimentation across science, design and society

    DEFF Research Database (Denmark)

    Boris, Stefan Darlan

    2016-01-01

    . This is something, which is becoming increasingly relevant, as landscape architects and urban planners today have to address the challenges confronting urbanism due to the continued entanglement of urbanisation and anthropogenic processes. These are challenges where the act of destabilizing dichotomies (inside......The article describes how the principal idea behind the landscape laboratories has been to develop a 1:1 platform where researchers, practitioners and lay people can meet and cooperate on the development and testing of new design concepts for establishing and managing urban landscapes....../outside, natural/manmade, etc.) is one out of several reasons for not only continuing but also strengthening the landscape laboratories as testing grounds for future urban landscapes and green spaces in the Anthropocene....

  8. 10 simple rules for best experimental design in ecology

    OpenAIRE

    Sajadi, Farwa

    2016-01-01

    A quick set of rules on how best to execute an experimental design in ecology. From having a clear hypothesis to obtaining accurate statistics, this guide will help make sure authors are on the right track before publishing. The 10 simple rules are based on articles written to help readers and editors learn more about experimental design and how to avoid any unseeable pitfalls. These rules act as a checklist for authors to go through to make sure they have created the best experimental design...

  9. Frontiers in Planar Lightwave Circuit Technology Design, Simulation, and Fabrication

    CERN Document Server

    Janz, Siegfried; Tanev, Stoyan

    2005-01-01

    This book is the result of the NATO Advanced Research Workshop on Frontiers in Planar Lightwave Circuit Technology, which took place in Ottawa, Canada from September 21-25, 2004. Many of the world’s leading experts in integrated photonic design, theory and experiment were invited to give lectures in their fields of expertise, and participate in discussions on current research and applications, as well as the new directions planar lightwave circuit technology is evolving towards. The sum of their contributions to this book constitutes an excellent record of many key issues and scientific problems in planar lightwave circuit research at the time of writing. In this volume the reader will find detailed overviews of experimental and theoretical work in high index contrast waveguide systems, micro-optical resonators, nonlinear optics, and advanced optical simulation methods, as well as articles describing emerging applications of integrated optics for medical and biological applications.

  10. Building design guidelines for solar energy technologies

    Energy Technology Data Exchange (ETDEWEB)

    Givoni, B.

    1989-01-01

    There are two main objectives to this publication. The first is to find out the communalities in the experience gained in previous studies and in actual applications of solar technologies in buildings, residential as well as nonresidential. The second objective is to review innovative concepts and products which may have an impact on future developments and applications of solar technologies in buildings. The available information and common lessons were collated and presented in a form which, hopefully, is useful for architects and solar engineers, as well as for teachers of solar architecture'' and students in Architectural Schools. The publication is based mainly on the collection and analysis of relevant information. The information included previous studies in which the performance of solar buildings was evaluated, as well as the personal experience of the Author and the research consultants. The state of the art, as indicated by these studies and personal experience, was summarized and has served as basis for the development of the Design Guidelines. In addition to the summary of the state of the art, as was already applied in solar buildings, an account was given of innovative concepts and products. Such innovations have occurred in the areas of thermal storage by Phase Change Materials (PCM) and in glazing with specialized or changeable properties. Interesting concepts were also developed for light transfer, which may enable to transfer sunlight to the core areas of large multi story nonresidential buildings. These innovations may have a significant impact on future developments of solar technologies and their applications in buildings. 15 refs., 19 figs., 3 tabs.

  11. Optimal screening designs for biomedical technology

    Energy Technology Data Exchange (ETDEWEB)

    Torney, D.C.; Bruno, W.J.; Knill, E. [and others

    1997-10-01

    This is the final report of a three-year, Laboratory Directed Research and Development (LDRD) project at Los Alamos National Laboratory (LANL). Screening a large number of different types of molecules to isolate a few with desirable properties is essential in biomedical technology. For example, trying to find a particular gene in the Human genome could be akin to looking for a needle in a haystack. Fortunately, testing of mixtures, or pools, of molecules allows the desirable ones to be identified, using a number of experiments proportional only to the logarithm of the total number of experiments proportional only to the logarithm of the total number of types of molecules. We show how to capitalize upon this potential by using optimize pooling schemes, or designs. We propose efficient non-adaptive pooling designs, such as {open_quotes}random sets{close_quotes} designs and modified {open_quotes}row and column{close_quotes} designs. Our results have been applied in the pooling and unique-sequence screening of clone libraries used in the Human Genome Project and in the mapping of Human chromosome 16. This required the use of liquid-transferring robots and manifolds--for the largest clone libraries. Finally, we developed an efficient technique for finding the posterior probability each molecule has the desirable property, given the pool assay results. This technique works well, in practice, even if there are substantial rates of errors in the pool assay data. Both our methods and our results are relevant to a broad spectrum of research in modern biology.

  12. Numerical taxonomy of maize landraces: comparison between experimental designs

    OpenAIRE

    1989-01-01

    [EN] Seventy three maize (Zea mays L.) landraces from Northwestern Spain were grown according to two different experimental design.The first one (design A) was a randomized complete blocks design with two replications per trial at two locations for two years. The second design (desing B) is simpler than the first one: the populations were grown at one location without replications for three years. Numerical taxonomy of these landraces was made according to results of the field trials u...

  13. Simultaneous optimal experimental design for in vitro binding parameter estimation.

    Science.gov (United States)

    Ernest, C Steven; Karlsson, Mats O; Hooker, Andrew C

    2013-10-01

    Simultaneous optimization of in vitro ligand binding studies using an optimal design software package that can incorporate multiple design variables through non-linear mixed effect models and provide a general optimized design regardless of the binding site capacity and relative binding rates for a two binding system. Experimental design optimization was employed with D- and ED-optimality using PopED 2.8 including commonly encountered factors during experimentation (residual error, between experiment variability and non-specific binding) for in vitro ligand binding experiments: association, dissociation, equilibrium and non-specific binding experiments. Moreover, a method for optimizing several design parameters (ligand concentrations, measurement times and total number of samples) was examined. With changes in relative binding site density and relative binding rates, different measurement times and ligand concentrations were needed to provide precise estimation of binding parameters. However, using optimized design variables, significant reductions in number of samples provided as good or better precision of the parameter estimates compared to the original extensive sampling design. Employing ED-optimality led to a general experimental design regardless of the relative binding site density and relative binding rates. Precision of the parameter estimates were as good as the extensive sampling design for most parameters and better for the poorly estimated parameters. Optimized designs for in vitro ligand binding studies provided robust parameter estimation while allowing more efficient and cost effective experimentation by reducing the measurement times and separate ligand concentrations required and in some cases, the total number of samples.

  14. Active Photonic Crystal Switches: Modeling, Design and Experimental Characterization

    DEFF Research Database (Denmark)

    Heuck, Mikkel; Yu, Yi; Kristensen, Philip Trøst;

    2013-01-01

    In this paper, we present recent progress in modeling, design, fabrication and experimental characterization of InP photonic crystal all-optical switches. Novel designs with increased flexibility and performance are presented, and their operation using high speed data signals is analyzed numerica......In this paper, we present recent progress in modeling, design, fabrication and experimental characterization of InP photonic crystal all-optical switches. Novel designs with increased flexibility and performance are presented, and their operation using high speed data signals is analyzed...

  15. The Use of an Experimental Design Approach to Investigate the ...

    African Journals Online (AJOL)

    The Use of an Experimental Design Approach to Investigate the Interactions of Additives ... When a conventional starting, lighting and ignition (SLI) lead acid battery is ... Typical flooded nominal 8 Ah test cells were assembled in a reverse ratio ...

  16. The nonstandard algorithm for constructing efficient conjoint experimental designs

    Directory of Open Access Journals (Sweden)

    Kuzmanović Marija

    2008-01-01

    Full Text Available Conjoint analysis is a research technique for measuring consumer preferences, and it is a method for simulating consumers' possible reactions to changes in current products or newly introduced products into an existing competitive market. One of the most critical steps in Conjoint analysis application is experimental designs construction. The purpose of an experimental design is to give a rough overall idea as to the shape of the experimental response surface, while only requiring a relatively small number of runs. These designs are expected to be orthogonal and balanced in an ideal case. In practice, though, it is hard to construct optimal designs and thus constructing of near optimal and efficient designs is carried out. There are several ways to quantify the relative efficiency of experimental designs. The choice of measure will determine which types of experimental designs are favored as well as the algorithms for choosing efficient designs. In this paper it is proposed the algorithm which combines one standard and one non-standard optimality criteria. The computational experiments were made, and results of comparison with algorithm implemented in commercial package SPSS confirm the efficiency of the proposed algorithm. .

  17. Process Model Construction and Optimization Using Statistical Experimental Design,

    Science.gov (United States)

    1988-04-01

    Memo No. 88-442 ~LECTE March 1988 31988 %,.. MvAY 1 98 0) PROCESS MODEL CONSTRUCTION AND OPTIMIZATION USING STATISTICAL EXPERIMENTAL DESIGN Emmanuel...Sachs and George Prueger Abstract A methodology is presented for the construction of process models by the combination of physically based mechanistic...253-8138. .% I " Process Model Construction and Optimization Using Statistical Experimental Design" by Emanuel Sachs Assistant Professor and George

  18. Model-Based Optimal Experimental Design for Complex Physical Systems

    Science.gov (United States)

    2015-12-03

    an open-loop behavior , where no feedback is involved , and the observations from any experiment do not affect the design of other experiments...developing and refining models of physical systems. Yet experimental observations can be difficult, time- consuming , and expensive to acquire. In this...improve design and decision-making under uncertainty. Yet experimental observations can be difficult, time- consuming , and expensive to acquire. In this

  19. Experimental Design: Utilizing Microsoft Mathematics in Teaching and Learning Calculus

    Science.gov (United States)

    Oktaviyanthi, Rina; Supriani, Yani

    2015-01-01

    The experimental design was conducted to investigate the use of Microsoft Mathematics, free software made by Microsoft Corporation, in teaching and learning Calculus. This paper reports results from experimental study details on implementation of Microsoft Mathematics in Calculus, students' achievement and the effects of the use of Microsoft…

  20. Design Issues and Inference in Experimental L2 Research

    Science.gov (United States)

    Hudson, Thom; Llosa, Lorena

    2015-01-01

    Explicit attention to research design issues is essential in experimental second language (L2) research. Too often, however, such careful attention is not paid. This article examines some of the issues surrounding experimental L2 research and its relationships to causal inferences. It discusses the place of research questions and hypotheses,…

  1. Design Issues and Inference in Experimental L2 Research

    Science.gov (United States)

    Hudson, Thom; Llosa, Lorena

    2015-01-01

    Explicit attention to research design issues is essential in experimental second language (L2) research. Too often, however, such careful attention is not paid. This article examines some of the issues surrounding experimental L2 research and its relationships to causal inferences. It discusses the place of research questions and hypotheses,…

  2. Conceptual design of superconducting magnet systems for the Argonne Tokamak Experimental Power Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Wang, S.T.; Turner, L.R.; Mills, F.E.; DeMichele, D.W.; Smelser, P.; Kim, S.H.

    1976-01-01

    As an integral effort in the Argonne Tokamak Experimental Power Reactor Conceptual Design, the conceptual design of a 10-tesla, pure-tension superconducting toroidal-field (TF) coil system has been developed in sufficient detail to define a realistic design for the TF coil system that could be built based upon the current state of technology with minimum technological extrapolations. A conceptual design study on the superconducting ohmic-heating (OH) coils and the superconducting equilibrium-field (EF) coils were also completed. These conceptual designs are developed in sufficient detail with clear information on high current ac conductor design, cooling, venting provision, coil structural support and zero loss poloidal coil cryostat design. Also investigated is the EF penetration into the blanket and shield.

  3. An Experimental Two-Way Video Teletraining System: Design, Development and Evaluation.

    Science.gov (United States)

    Simpson, Henry; And Others

    1991-01-01

    Describes the design, development, and evaluation of an experimental two-way video teletraining (VTT) system by the Navy that consisted of two classrooms linked by a land line to enable two-way audio/video communication. Trends in communication and computer technology for training are described, and a cost analysis is included. (12 references)…

  4. An Experimental Two-Way Video Teletraining System: Design, Development and Evaluation.

    Science.gov (United States)

    Simpson, Henry; And Others

    1991-01-01

    Describes the design, development, and evaluation of an experimental two-way video teletraining (VTT) system by the Navy that consisted of two classrooms linked by a land line to enable two-way audio/video communication. Trends in communication and computer technology for training are described, and a cost analysis is included. (12 references)…

  5. A Bayesian experimental design approach to structural health monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Farrar, Charles [Los Alamos National Laboratory; Flynn, Eric [UCSD; Todd, Michael [UCSD

    2010-01-01

    Optimal system design for SHM involves two primarily challenges. The first is the derivation of a proper performance function for a given system design. The second is the development of an efficient optimization algorithm for choosing a design that maximizes, or nearly maximizes the performance function. In this paper we will outline how an SHM practitioner can construct the proper performance function by casting the entire design problem into a framework of Bayesian experimental design. The approach demonstrates how the design problem necessarily ties together all steps of the SHM process.

  6. An Application of Latent Variable Structural Equation Modeling For Experimental Research in Educational Technology

    National Research Council Canada - National Science Library

    Hyeon Woo LEE

    2011-01-01

      AN APPLICATION OF LATENT VARIABL AN APPLICATION OF LATENT VARIABLE STRUCTURAL EQUATION MODELING FOR EXPERIMENTAL RESEARCH IN EDUCATIONAL TECHNOLOGY As the technology-enriched learning environments...

  7. Scientific Knowledge and Technology, Animal Experimentation, and Pharmaceutical Development.

    Science.gov (United States)

    Kinter, Lewis B; DeGeorge, Joseph J

    2016-12-01

    Human discovery of pharmacologically active substances is arguably the oldest of the biomedical sciences with origins >3500 years ago. Since ancient times, four major transformations have dramatically impacted pharmaceutical development, each driven by advances in scientific knowledge, technology, and/or regulation: (1) anesthesia, analgesia, and antisepsis; (2) medicinal chemistry; (3) regulatory toxicology; and (4) targeted drug discovery. Animal experimentation in pharmaceutical development is a modern phenomenon dating from the 20th century and enabling several of the four transformations. While each transformation resulted in more effective and/or safer pharmaceuticals, overall attrition, cycle time, cost, numbers of animals used, and low probability of success for new products remain concerns, and pharmaceutical development remains a very high risk business proposition. In this manuscript we review pharmaceutical development since ancient times, describe its coevolution with animal experimentation, and attempt to predict the characteristics of future transformations.

  8. Randomizing Roaches: Exploring the "Bugs" of Randomization in Experimental Design

    Science.gov (United States)

    Wagler, Amy; Wagler, Ron

    2014-01-01

    Understanding the roles of random selection and random assignment in experimental design is a central learning objective in most introductory statistics courses. This article describes an activity, appropriate for a high school or introductory statistics course, designed to teach the concepts, values and pitfalls of random selection and assignment…

  9. Fundamentals of experimental design: lessons from beyond the textbook world

    Science.gov (United States)

    We often think of experimental designs as analogous to recipes in a cookbook. We look for something that we like and frequently return to those that have become our long-standing favorites. We can easily become complacent, favoring the tried-and-true designs (or recipes) over those that contain unkn...

  10. Experimental Design and Multiplexed Modeling Using Titrimetry and Spreadsheets

    Science.gov (United States)

    Harrington, Peter De B.; Kolbrich, Erin; Cline, Jennifer

    2002-07-01

    The topics of experimental design and modeling are important for inclusion in the undergraduate curriculum. Many general chemistry and quantitative analysis courses introduce students to spreadsheet programs, such as MS Excel. Students in the laboratory sections of these courses use titrimetry as a quantitative measurement method. Unfortunately, the only model that students may be exposed to in introductory chemistry courses is the working curve that uses the linear model. A novel experiment based on a multiplex model has been devised for titrating several vinegar samples at a time. The multiplex titration can be applied to many other routine determinations. An experimental design model is fit to titrimetric measurements using the MS Excel LINEST function to estimate concentration from each sample. This experiment provides valuable lessons in error analysis, Class A glassware tolerances, experimental simulation, statistics, modeling, and experimental design.

  11. Design review of the Brazilian Experimental Solar Telescope

    Science.gov (United States)

    Dal Lago, A.; Vieira, L. E. A.; Albuquerque, B.; Castilho, B.; Guarnieri, F. L.; Cardoso, F. R.; Guerrero, G.; Rodríguez, J. M.; Santos, J.; Costa, J. E. R.; Palacios, J.; da Silva, L.; Alves, L. R.; Costa, L. L.; Sampaio, M.; Dias Silveira, M. V.; Domingues, M. O.; Rockenbach, M.; Aquino, M. C. O.; Soares, M. C. R.; Barbosa, M. J.; Mendes, O., Jr.; Jauer, P. R.; Branco, R.; Dallaqua, R.; Stekel, T. R. C.; Pinto, T. S. N.; Menconi, V. E.; Souza, V. M. C. E. S.; Gonzalez, W.; Rigozo, N.

    2015-12-01

    The Brazilian's National Institute for Space Research (INPE), in collaboration with the Engineering School of Lorena/University of São Paulo (EEL/USP), the Federal University of Minas Gerais (UFMG), and the Brazilian's National Laboratory for Astrophysics (LNA), is developing a solar vector magnetograph and visible-light imager to study solar processes through observations of the solar surface magnetic field. The Brazilian Experimental Solar Telescope is designed to obtain full disk magnetic field and line-of-sight velocity observations in the photosphere. Here we discuss the system requirements and the first design review of the instrument. The instrument is composed by a Ritchey-Chrétien telescope with a 500 mm aperture and 4000 mm focal length. LCD polarization modulators will be employed for the polarization analysis and a tuning Fabry-Perot filter for the wavelength scanning near the Fe II 630.25 nm line. Two large field-of-view, high-resolution 5.5 megapixel sCMOS cameras will be employed as sensors. Additionally, we describe the project management and system engineering approaches employed in this project. As the magnetic field anchored at the solar surface produces most of the structures and energetic events in the upper solar atmosphere and significantly influences the heliosphere, the development of this instrument plays an important role in advancing scientific knowledge in this field. In particular, the Brazilian's Space Weather program will benefit most from the development of this technology. We expect that this project will be the starting point to establish a strong research program on Solar Physics in Brazil. Our main aim is to progressively acquire the know-how to build state-of-art solar vector magnetograph and visible-light imagers for space-based platforms.

  12. Leveraging the Experimental Method to Inform Solar Cell Design

    Science.gov (United States)

    Rose, Mary Annette; Ribblett, Jason W.; Hershberger, Heather Nicole

    2010-01-01

    In this article, the underlying logic of experimentation is exemplified within the context of a photoelectrical experiment for students taking a high school engineering, technology, or chemistry class. Students assume the role of photochemists as they plan, fabricate, and experiment with a solar cell made of copper and an aqueous solution of…

  13. Leveraging the Experimental Method to Inform Solar Cell Design

    Science.gov (United States)

    Rose, Mary Annette; Ribblett, Jason W.; Hershberger, Heather Nicole

    2010-01-01

    In this article, the underlying logic of experimentation is exemplified within the context of a photoelectrical experiment for students taking a high school engineering, technology, or chemistry class. Students assume the role of photochemists as they plan, fabricate, and experiment with a solar cell made of copper and an aqueous solution of…

  14. Experimental Methodology in English Teaching and Learning: Method Features, Validity Issues, and Embedded Experimental Design

    Science.gov (United States)

    Lee, Jang Ho

    2012-01-01

    Experimental methods have played a significant role in the growth of English teaching and learning studies. The paper presented here outlines basic features of experimental design, including the manipulation of independent variables, the role and practicality of randomised controlled trials (RCTs) in educational research, and alternative methods…

  15. Some Big Questions about Design in Educational Technology

    Science.gov (United States)

    Gibbons, Andrew S.

    2016-01-01

    This article asks five questions that lead us to the foundations of design practice in educational technology. Design processes structure time, space, place, activity, role, goal, and resource. For educational technology to advance in its understanding of design practice, it must question whether we have clear conceptions of how abstract…

  16. A Framework Theorizing Design of Human Technologies

    DEFF Research Database (Denmark)

    Nielsen, Jørgen Lerche; Riis, Søren; Simonsen, Jesper;

    Design is increasingly becoming a part of the university curriculum and research agenda. It is argued that it is in the interest of many design communities – also the DASTS community – to engage in theorizing design, on the basis of our understanding of design and design practices.......Design is increasingly becoming a part of the university curriculum and research agenda. It is argued that it is in the interest of many design communities – also the DASTS community – to engage in theorizing design, on the basis of our understanding of design and design practices....

  17. Demonstrating the benefits of template-based design-technology co-optimization

    Science.gov (United States)

    Liebmann, Lars; Hibbeler, Jason; Hieter, Nathaniel; Pileggi, Larry; Jhaveri, Tejas; Moe, Matthew; Rovner, Vyacheslav

    2010-03-01

    The concept of template-based design-technology co-optimization as a means of curbing escalating design complexity and increasing technology qualification risk is described. Data is presented highlighting the design efficacy of this proposal in terms of power, performance, and area benefits, quantifying the specific contributions of complex logic gates in this design optimization. Experimental results from 32nm technology node bulk CMOS wafers are presented to quantify the variability and design-margin reductions as well as yield and manufacturability improvements achievable with the proposed template-based design-technology co-optimization technique. The paper closes with data showing the predictable composability of individual templates, demonstrating a fundamental requirement of this proposal.

  18. Experimental system design for the integration of trapped-ion and superconducting qubit systems

    Science.gov (United States)

    De Motte, D.; Grounds, A. R.; Rehák, M.; Rodriguez Blanco, A.; Lekitsch, B.; Giri, G. S.; Neilinger, P.; Oelsner, G.; Il'ichev, E.; Grajcar, M.; Hensinger, W. K.

    2016-12-01

    We present a design for the experimental integration of ion trapping and superconducting qubit systems as a step towards the realization of a quantum hybrid system. The scheme addresses two key difficulties in realizing such a system: a combined microfabricated ion trap and superconducting qubit architecture, and the experimental infrastructure to facilitate both technologies. Developing upon work by Kielpinski et al. (Phys Rev Lett 108(13):130504, 2012. doi: 10.1103/PhysRevLett.108.130504), we describe the design, simulation and fabrication process for a microfabricated ion trap capable of coupling an ion to a superconducting microwave LC circuit with a coupling strength in the tens of kHz. We also describe existing difficulties in combining the experimental infrastructure of an ion trapping set-up into a dilution refrigerator with superconducting qubits and present solutions that can be immediately implemented using current technology.

  19. Liquid metal reactor development. Development of LMR design technology

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Young Cheol; Kim, Y. I.; Kim, Y. G.; Kim, E. K.; Song, H.; Chung, H. T.; Sim, Y. S.; Min, B. T.; Kim, Y. S.; Wi, M. H.; Yoo, B.; Lee, J. H.; Lee, H. Y.; Kim, J. B.; Koo, G. H.; Hahn, D. H.; Na, B. C.; Hwang, W.; Nam, C.; Ryu, W. S.; Lim, G. S.; Kim, D. H.; Kim, J. D.; Gil, C. S.

    1997-07-01

    This project was performed in five parts, the scope and contents of which are as follows: The nuclear data processing system was established and the KFS group constant library was improved and verified. Basic computation system was constructed by either developing or adding its function. Input/output (I/O) interface processing was developed to establish an integrated calculation system for LMR core nuclear rand thermal-hydraulic design and analysis. An experimental data analysis was performed to validate the constructed core neutronic calculation system. Using the established core calculation system and design technology, preliminary core design and performance analysis on the domestic LMR core design concept were carried out. To develop the basic technology of the LMR system analysis, LMR system behavior characteristics evaluation, thermal -fluid system analysis in the reactor pool, preliminary overall plant analysis and computer codes development have been performed. A porous model and simple one-dimensional model have been evaluated for the reactor pool analysis. The evaluation of the residual heat removal system on different design concepts has been also conducted. For the development of high temperature structural analysis, the heat transfer and thermal stress analyses were performed using finite element program with user subroutine that has been developed with an implementation of the Chaboche constitutive model for inelastic analysis capability, and the evaluation of creep-fatigue and ratcheting behavior of high temperature structure was carried out using this program. for development of the seismic isolation system and to predict the shear behavior for the laminated rubber bearing were established. And the behavior tests of isolation bearing and rubber specimens were carried out, and the seismic response tests for the isolation model structure were performed using the 30 ton shaking table. (author). 369 refs., 119 tabs., 320 figs.

  20. Contemporary experimental aesthetics: State of the art technology.

    Science.gov (United States)

    Locher, Paul

    2011-01-01

    The purpose of this essay is to provide the reader with a brief overview of several recent person-artifact-context relational models that explain the complex interaction of the processes that underlie an ongoing aesthetic experience with visual art forms. Recent progress towards a comprehensive understanding of these processes has been made possible in large part by experimental approaches that take advantage of recent advances in computer technology and electronic sophistication. To illustrate this point, three experimental techniques at the forefront of the field of experimental aesthetics are highlighted here. They include the investigation of viewers- body postural adjustments to depicted pictorial depth and movement in paintings; the use of hand-held computers known as personal data assistants to record audience members- on-going emotional reactions to live performances of dance; and the contribution of audio tour information to museum visitors- interaction with and aesthetic evaluation of sculptures and paintings. Finally, the eMotion: Mapping Museum Experience project, which has the potential to make a tremendous contribution to the understanding of the complex interaction of factors that contribute to a museum visitor's experience, is described.

  1. Active vibration absorber for the CSI evolutionary model - Design and experimental results. [Controls Structures Interaction

    Science.gov (United States)

    Bruner, Anne M.; Belvin, W. Keith; Horta, Lucas G.; Juang, Jer-Nan

    1991-01-01

    The development of control of large flexible structures technology must include practical demonstrations to aid in the understanding and characterization of controlled structures in space. To support this effort, a testbed facility has been developed to study practical implementation of new control technologies under realistic conditions. The paper discusses the design of a second order, acceleration feedback controller which acts as an active vibration absorber. This controller provides guaranteed stability margins for collocated sensor/actuator pairs in the absence of sensor/actuator dynamics and computational time delay. Experimental results in the presence of these factors are presented and discussed. The robustness of this design under model uncertainty is demonstrated.

  2. Design and Experimental Study on Spinning Solid Rocket Motor

    Science.gov (United States)

    Xue, Heng; Jiang, Chunlan; Wang, Zaicheng

    The study on spinning solid rocket motor (SRM) which used as power plant of twice throwing structure of aerial submunition was introduced. This kind of SRM which with the structure of tangential multi-nozzle consists of a combustion chamber, propellant charge, 4 tangential nozzles, ignition device, etc. Grain design, structure design and prediction of interior ballistic performance were described, and problem which need mainly considered in design were analyzed comprehensively. Finally, in order to research working performance of the SRM, measure pressure-time curve and its speed, static test and dynamic test were conducted respectively. And then calculated values and experimental data were compared and analyzed. The results indicate that the designed motor operates normally, and the stable performance of interior ballistic meet demands. And experimental results have the guidance meaning for the pre-research design of SRM.

  3. Characterizing the Experimental Procedure in Science Laboratories: A Preliminary Step towards Students Experimental Design

    Science.gov (United States)

    Girault, Isabelle; d'Ham, Cedric; Ney, Muriel; Sanchez, Eric; Wajeman, Claire

    2012-01-01

    Many studies have stressed students' lack of understanding of experiments in laboratories. Some researchers suggest that if students design all or parts of entire experiment, as part of an inquiry-based approach, it would overcome certain difficulties. It requires that a procedure be written for experimental design. The aim of this paper is to…

  4. Measuring Diagnostic Stand for Experimental Researches in Technology Machining

    Directory of Open Access Journals (Sweden)

    A. E. Dreval'

    2014-01-01

    Full Text Available The paper reviews applied techniques, methods, and structure of the control and measuring means to conduct experimental and scientific researches of cutting processes. Existing research methods in cutting the metals are divided by features, such as essence of methods, the number of records of physical indicators, the number of studied factors, duration of tests. The groups of methods are briefly characterized.The chair "Tool Engineering and Technologies" of BMSTU developed and made a diagnostic stand of control and measurements for conducting research activities in the field of materials processing technology by cutting to define rational technological decisions, when machining, and carry out an analysis of efficiency and economic feasibility of made decisions. The diagnostic stand contains modern the electronic equipment. Record of measuring parameters is made in real time with a possibility for visual representation of read results and mathematical and statistical processing of measurement results. The stand can be used in research laboratories of machine-building enterprises, laboratories of higher education institutions, and other scientific divisions.The paper presents a justification that the stand is reasonable to use for the following: completion and choice of rational cutting modes, workability assessment of new constructional materials, technical and operational characteristics of the processed surfaces, and operational properties of the cutting tools of various producers, choice of optimum geometrical parameters of the cutting tools and brands of the lubricant cooling technological means, as well as the energy consumption for the chosen machining process. The stand allows us to make an assessment of wear resistance and tribology-technical characteristics of tool materials, as well as an accuracy, rigidity, vibration stability of machines, both new and being in operation.

  5. MODERN TECHNOLOGIES AND APPROACHES TO APOPTOSIS STUDIES IN EXPERIMENTAL BIOLOGY

    Directory of Open Access Journals (Sweden)

    I. V. Kudriavtsev

    2012-01-01

    Full Text Available Abstract. This review is focused on analysis of currently used flow cytometric methods designed foridentifying apoptotic cells in various invertebrate and vertebrate species. Apoptosis can be characterized by stage-specific morphological and biochemical changes that are typical to all kinds of eukaryotic cells. In this article, we consider different techniques of apoptosis detection based on assessment of cellular morphology and plasma membrane alterations, activation of intracellular enzymes and components of a caspase cascade, as well as DNA fragmentation and failure of mitochondrial transmembrane potential, as assessed in various animal groups. Apoptosis recognized as a key mechanism aiming at maintenance of cellular homeostasis in multicellular organisms, and such investigations represent a necessary component of fundamental and applied studies in diverse fields of experimental biology and immunology. A broad spectrum of apoptosis markers isused, and the preference is given to optimal approaches, as determined by experimental tasks, and technical opportunities of the laboratory.

  6. Useful experimental designs and rank order statistics in educational research

    Directory of Open Access Journals (Sweden)

    Zendler, Andreas

    2013-01-01

    Full Text Available Experimental educational research is of great impact because it illuminates cause-and-effect relationships by accumulating empirical evidence. The present article does not propose new methods but brings three useful experimental designs as well as appropriate statistical procedures (rank order statistics to the attention of the reader to conduct educational experiments, even with small samples. By means of their systematic use combined with the process-product paradigm of experimental educational research, the influence of essential variables (teacher, context, and process variables in schools, universities, and other educational institutions can be investigated. The statistical procedures described in this article guarantee that small samples (e.g. a school class can be successfully used, and that product variables (e.g. knowledge, comprehension, transfer are only required to meet the criteria of an ordinal scale. The experimental designs and statistical procedures are exemplified by hypothetical data and detailed calculations.

  7. Reliability of single sample experimental designs: comfortable effort level.

    Science.gov (United States)

    Brown, W S; Morris, R J; DeGroot, T; Murry, T

    1998-12-01

    This study was designed to ascertain the intrasubject variability across multiple recording sessions-most often disregarded in reporting group mean data or unavailable because of single sample experimental designs. Intrasubject variability was assessed within and across several experimental sessions from measures of speaking fundamental frequency, vocal intensity, and reading rate. Three age groups of men and women--young, middle-aged, and elderly--repeated the vowel /a/, read a standard passage, and spoke extemporaneously during each experimental session. Statistical analyses were performed to assess each speaker's variability from his or her own mean, and that which consistently varied for any one speaking sample type, both within or across days. Results indicated that intrasubject variability was minimal, with approximately 4% of the data exhibiting significant variation across experimental sessions.

  8. Underpinning the STEM Agenda through Technological Textiles? An Exploration of Design Technology Teachers' Attitudes

    Science.gov (United States)

    Hughes, Chris; Bell, Dawne

    2011-01-01

    This paper discusses ongoing research into the role of design and technology education in emerging post industrial economies. Previous work (Hughes et al., 2010) focused on the changing characteristics of textiles technology in modern times and discussed how this could inform a design and technology curriculum related to the needs of a modern…

  9. Computer-Generated Experimental Designs for Irregular-Shaped Regions

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen, Nam K.; Piepel, Gregory F.

    2005-09-01

    This paper focuses on the construction of computer-generated designs on irregularly-shaped, constrained regions. Overviews of the Fedorov exchange algorithm (FEA) and other exchange algorithms for the construction of D-optimal designs are given. A faster implementation of the FEA is presented, which is referred to as fast-FEA (denoted FFEA). The FFEA was applied to construct D-optimal designs for several published examples with constrained experimental regions. Designs resulting from the FFEA are more D-efficient than published designs, and provide benchmarks for future comparisons of design construction algorithms. The construction of G-optimal designs for constrained regions is also discussed and illustrated with a published example.

  10. Design, Simulation and Experimental Investigation of a Solar System Based on PV Panels and PVT Collectors

    Directory of Open Access Journals (Sweden)

    Annamaria Buonomano

    2016-06-01

    Full Text Available This paper presents numerical and experimental analyses aimed at evaluating the technical and economic feasibility of photovoltaic/thermal (PVT collectors. An experimental setup was purposely designed and constructed in order to compare the electrical performance of a PVT solar field with the one achieved by an identical solar field consisting of conventional photovoltaic (PV panels. The experimental analysis also aims at evaluating the potential advantages of PVT vs. PV in terms of enhancement of electrical efficiency and thermal energy production. The installed experimental set-up includes four flat polycrystalline silicon PV panels and four flat unglazed polycrystalline silicon PVT collectors. The total electrical power and area of the solar field are 2 kWe and 13 m2, respectively. The experimental set-up is currently installed at the company AV Project Ltd., located in Avellino (Italy. This study also analyzes the system from a numerical point of view, including a thermo-economic dynamic simulation model for the design and the assessment of energy performance and economic profitability of the solar systems consisting of glazed PVT and PV collectors. The experimental setup was modelled and partly simulated in TRNSYS environment. The simulation model was useful to analyze efficiencies and temperatures reached by such solar technologies, by taking into account the reference technology of PVTs (consisting of glazed collectors as well as to compare the numerical data obtained by dynamic simulations with the gathered experimental results for the PV technology. The numerical analysis shows that the PVT global efficiency is about 26%. Conversely, from the experimental point of view, the average thermal efficiency of PVT collectors is around 13% and the electrical efficiencies of both technologies are almost coincident and equal to 15%.

  11. Optimal Experimental Design of Furan Shock Tube Kinetic Experiments

    KAUST Repository

    Kim, Daesang

    2015-01-07

    A Bayesian optimal experimental design methodology has been developed and applied to refine the rate coefficients of elementary reactions in Furan combustion. Furans are considered as potential renewable fuels. We focus on the Arrhenius rates of Furan + OH ↔ Furyl-2 + H2O and Furan ↔ OH Furyl-3 + H2O, and rely on the OH consumption rate as experimental observable. A polynomial chaos surrogate is first constructed using an adaptive pseudo-spectral projection algorithm. The PC surrogate is then exploited in conjunction with a fast estimation of the expected information gain in order to determine the optimal design in the space of initial temperatures and OH concentrations.

  12. Development of fluid and I and C systems design technology

    Energy Technology Data Exchange (ETDEWEB)

    Sim, Yoon Sub; Park, C. K.; Kim, S. O. [and others

    2000-05-01

    LMR is the reactor type that makes utilization of uranium resource very efficiently and the necessity of construction of a LMR in 2020's has been raised. However, the design technology required for construction has not been secured domestically. To fulfill the necessity, study has been made for the LMR system design technology and conceptual design of KALIMER systems for fluid, instrumentation, control, and protection have been developed. Also the computer code systems for the design and analysis of the KALIMER fluid systems have been developed. These study results are to used as the starting point of the next phase LMR design technology development research.

  13. Development of Experimental Facilities for Advanced Spent Fuel Management Technology

    Energy Technology Data Exchange (ETDEWEB)

    You, G. S.; Jung, W. M.; Ku, J. H. [and others

    2004-07-01

    The advanced spent fuel management process(ACP), proposed to reduce the overall volume of the PWR spent fuel and improve safety and economy of the long-term storage of spent fuel, is under research and development. This technology convert spent fuels into pure metal-base uranium with removing the highly heat generating materials(Cs, Sr) efficiently and reducing of the decay heat, volume, and radioactivity from spent fuel by 1/4. In the next phase(2004{approx}2006), the demonstration of this technology will be carried out for verification of the ACP in a laboratory scale. For this demonstration, the hot cell facilities of {alpha}-{gamma} type and auxiliary facilities are required essentially for safe handling of high radioactive materials. As the hot cell facilities for demonstration of the ACP, a existing hot cell of {beta}-{gamma} type will be refurbished to minimize construction expenditures of hot cell facility. In this study, the design requirements are established, and the process detail work flow was analysed for the optimum arrangement to ensure effective process operation in hot cell. And also, the basic and detail design of hot cell facility and process, and safety analysis was performed to secure conservative safety of hot cell facility and process.

  14. Overview of the MedAustron design and technology choices

    CERN Document Server

    Benedikt, M; Palm, M; Pirkl, W; Dorda, U; Fabich, A

    2010-01-01

    MedAustron is a synchrotron based accelerator facility for cancer treatment in Austria currently in the development phase. The design is based on the PIMMS study [1] and CNAO [2] synchrotron. In addition to the clinical application, the accelerator will also provide beams for nonclinical research in the fields of medical radiation physics, radiation biology and experimental physics with an extended proton energy range beyond medical requirements to 800 MeV. The differences to others medical acceleratorbased facilities will be elaborated, specifically the used source technologies and configuration (starting up with protons (p) and carbon ions (C6+) allowing a later upgrade to ion species up to neon) and the online verification of all relevant beam parameters. The current project status is presented.

  15. Principles of Experimental Design for Big Data Analysis.

    Science.gov (United States)

    Drovandi, Christopher C; Holmes, Christopher; McGree, James M; Mengersen, Kerrie; Richardson, Sylvia; Ryan, Elizabeth G

    2017-08-01

    Big Datasets are endemic, but are often notoriously difficult to analyse because of their size, heterogeneity and quality. The purpose of this paper is to open a discourse on the potential for modern decision theoretic optimal experimental design methods, which by their very nature have traditionally been applied prospectively, to improve the analysis of Big Data through retrospective designed sampling in order to answer particular questions of interest. By appealing to a range of examples, it is suggested that this perspective on Big Data modelling and analysis has the potential for wide generality and advantageous inferential and computational properties. We highlight current hurdles and open research questions surrounding efficient computational optimisation in using retrospective designs, and in part this paper is a call to the optimisation and experimental design communities to work together in the field of Big Data analysis.

  16. Optimal Bayesian experimental design for contaminant transport parameter estimation

    CERN Document Server

    Tsilifis, Panagiotis; Hajali, Paris

    2015-01-01

    Experimental design is crucial for inference where limitations in the data collection procedure are present due to cost or other restrictions. Optimal experimental designs determine parameters that in some appropriate sense make the data the most informative possible. In a Bayesian setting this is translated to updating to the best possible posterior. Information theoretic arguments have led to the formation of the expected information gain as a design criterion. This can be evaluated mainly by Monte Carlo sampling and maximized by using stochastic approximation methods, both known for being computationally expensive tasks. We propose an alternative framework where a lower bound of the expected information gain is used as the design criterion. In addition to alleviating the computational burden, this also addresses issues concerning estimation bias. The problem of permeability inference in a large contaminated area is used to demonstrate the validity of our approach where we employ the massively parallel vers...

  17. Recent developments in optimal experimental designs for functional magnetic resonance imaging

    Institute of Scientific and Technical Information of China (English)

    Ming-Hung; Kao; M’hamed; Temkit; Weng; Kee; Wong

    2014-01-01

    Functional magnetic resonance imaging(fMRI)is one of the leading brain mapping technologies for studying brain activity in response to mental stimuli.For neuroimaging studies utilizing this pioneering technology,there is a great demand of high-quality experimental designs that help to collect informative data to make precise and valid inference about brain functions.This paper provides a survey on recent developments in experimental designs for fMRI studies.We briefly introduce some analytical and computational tools for obtaining good designs based on a specified design selection criterion.Research results about some commonly considered designs such as blocked designs,and m-sequences are also discussed.Moreover,we present a recently proposed new type of fMRI designs that can be constructed using a certain type of Hadamard matrices.Under certain assumptions,these designs can be shown to be statistically optimal.Some future research directions in design of fMRI experiments are also discussed.

  18. Impact of Computer Technology on Design and Craft Education

    Science.gov (United States)

    Thorsteinsson, Gisli

    2014-01-01

    This research aims to answer the question, "How has the use of computer technology benefited the compulsory education system, focusing on Design and Technology?" In order to reply this question, it was necessary to focus on interactive whiteboards, e-portfolios and digital projectors as the main technology formats. An initial literature…

  19. Teachers' Purposeful Design of Effective Technology Learning Activities

    Science.gov (United States)

    Morgan, John Andrew Kerlin

    2014-01-01

    The goal of this study was to explore how exemplary teachers design learning activities that incorporate the use of technology. Teachers at three schools in a school district in Southern California were solicited for a survey regarding their use of technology in the classroom. Based on the surveys, high and low technology implementers were…

  20. M-Learning Systems Design--Technology and Pedagogy Aspects

    Science.gov (United States)

    Gourova, Elissaveta; Asenova, Asya; Dulev, Pavlin

    2013-01-01

    Technology developments face universities with many challenges--to integrate technologies in educational processes, design new electronic materials, change teaching styles, and better meet the demands of the technology-savvy generation. The paper considers problems of m-learning adoption in Bulgaria at one Faculty of the Technical…

  1. Designing a Learning Curriculum and Technology's Role in It

    Science.gov (United States)

    Gerber, Sue; Scott, Logan

    2007-01-01

    This paper presents a case study of the design and implementation of a master's level research course. Factors that defined the curriculum design problem included the subject matter, a view of learning as a change in identity, and the role of technology in curriculum design. Both the design process and results of research on the implementation of…

  2. Experimental design for stable genetic manipulation in mammalian cell lines: lentivirus and alternatives.

    Science.gov (United States)

    Shearer, Robert F; Saunders, Darren N

    2015-01-01

    The use of third-generation lentiviral vectors is now commonplace in most areas of basic biology. These systems provide a fast, efficient means for modulating gene expression, but experimental design needs to be carefully considered to minimize potential artefacts arising from off-target effects and other confounding factors. This review offers a starting point for those new to lentiviral-based vector systems, addressing the main issues involved with the use of lentiviral systems in vitro and outlines considerations which should be taken into account during experimental design. Factors such as selecting an appropriate system and controls, and practical titration of viral transduction are important considerations for experimental design. We also briefly describe some of the more recent advances in genome editing technology. TALENs and CRISPRs offer an alternative to lentivirus, providing endogenous gene editing with reduced off-target effects often at the expense of efficiency.

  3. BASELINE DESIGN/ECONOMICS FOR ADVANCED FISCHER-TROPSCH TECHNOLOGY

    Energy Technology Data Exchange (ETDEWEB)

    None

    1998-04-01

    Bechtel, along with Amoco as the main subcontractor, developed a Baseline design, two alternative designs, and computer process simulation models for indirect coal liquefaction based on advanced Fischer-Tropsch (F-T) technology for the U. S. Department of Energy's (DOE's) Federal Energy Technology Center (FETC).

  4. Technological Challenges: Designing Large Compressed Video and Multimedia Classrooms.

    Science.gov (United States)

    Hart, Russ A.; Parker, Roger

    Designing a distance learning classroom requires integration of educational goals and philosophy with technology and ergonomics. The technological challenge and key to designing effective distance learning and multimedia classrooms is creating an environment in which the participants--students, and teacher--may easily interact with instructional…

  5. Do we need teachers as designers of technology enhanced learning?

    NARCIS (Netherlands)

    Kirschner, Paul A.

    2016-01-01

    In this special issue, five teams of researchers discuss different aspects of the teacher as designer of technology enhanced learning situations. This final contribution critically discusses if and how teachers as designers of technology enhanced learning might (not) be feasible or even desirable. T

  6. Design and Construction of a Multimedia Technology Cart.

    Science.gov (United States)

    Hofstetter, Fred T.; And Others

    1993-01-01

    Describes a mobile classroom presentation cart for multimedia technology that was designed and constructed at the University of Delaware's Instructional Technology Center. Design goals are discussed; the physical layout is explained; equipment choices are described, including computer, audio system, and projection system; and future development is…

  7. Aircraft propulsion systems technology and design

    National Research Council Canada - National Science Library

    Oates, Gordon C

    1989-01-01

    ... propulsion technology planned by Gordon C. Gates. Other titles: Aerothermodynamics of gas turbine and rocket propulsion (c!988); Aerothermodynamics of aircraft engine com.ponents (c!985). Includes b...

  8. A modified experimental hut design for studying responses of disease-transmitting mosquitoes to indoor interventions: the Ifakara experimental huts.

    Directory of Open Access Journals (Sweden)

    Fredros O Okumu

    Full Text Available Differences between individual human houses can confound results of studies aimed at evaluating indoor vector control interventions such as insecticide treated nets (ITNs and indoor residual insecticide spraying (IRS. Specially designed and standardised experimental huts have historically provided a solution to this challenge, with an added advantage that they can be fitted with special interception traps to sample entering or exiting mosquitoes. However, many of these experimental hut designs have a number of limitations, for example: 1 inability to sample mosquitoes on all sides of huts, 2 increased likelihood of live mosquitoes flying out of the huts, leaving mainly dead ones, 3 difficulties of cleaning the huts when a new insecticide is to be tested, and 4 the generally small size of the experimental huts, which can misrepresent actual local house sizes or airflow dynamics in the local houses. Here, we describe a modified experimental hut design - The Ifakara Experimental Huts- and explain how these huts can be used to more realistically monitor behavioural and physiological responses of wild, free-flying disease-transmitting mosquitoes, including the African malaria vectors of the species complexes Anopheles gambiae and Anopheles funestus, to indoor vector control-technologies including ITNs and IRS. Important characteristics of the Ifakara experimental huts include: 1 interception traps fitted onto eave spaces and windows, 2 use of eave baffles (panels that direct mosquito movement to control exit of live mosquitoes through the eave spaces, 3 use of replaceable wall panels and ceilings, which allow safe insecticide disposal and reuse of the huts to test different insecticides in successive periods, 4 the kit format of the huts allowing portability and 5 an improved suite of entomological procedures to maximise data quality.

  9. Applications of Chemiluminescence in the Teaching of Experimental Design

    Science.gov (United States)

    Krawczyk, Tomasz; Slupska, Roksana; Baj, Stefan

    2015-01-01

    This work describes a single-session laboratory experiment devoted to teaching the principles of factorial experimental design. Students undertook the rational optimization of a luminol oxidation reaction, using a two-level experiment that aimed to create a long-lasting bright emission. During the session students used only simple glassware and…

  10. Single-Subject Experimental Design for Evidence-Based Practice

    Science.gov (United States)

    Byiers, Breanne J.; Reichle, Joe; Symons, Frank J.

    2012-01-01

    Purpose: Single-subject experimental designs (SSEDs) represent an important tool in the development and implementation of evidence-based practice in communication sciences and disorders. The purpose of this article is to review the strategies and tactics of SSEDs and their application in speech-language pathology research. Method: The authors…

  11. Experimental design of natural and accellerated bone and wood ageing

    DEFF Research Database (Denmark)

    Facorellis, Y.; Pournou, A.; Richter, Jane;

    2015-01-01

    This paper presents the experimental design for natural and accelerated ageing of bone and wood samples found in museum conditions that was conceived as part of the INVENVORG (Thales Research Funding Program – NRSF) investigating the effects of the environmental factors on natural organic materials....

  12. Using Propensity Score Methods to Approximate Factorial Experimental Designs

    Science.gov (United States)

    Dong, Nianbo

    2011-01-01

    The purpose of this study is through Monte Carlo simulation to compare several propensity score methods in approximating factorial experimental design and identify best approaches in reducing bias and mean square error of parameter estimates of the main and interaction effects of two factors. Previous studies focused more on unbiased estimates of…

  13. Model selection in systems biology depends on experimental design.

    Science.gov (United States)

    Silk, Daniel; Kirk, Paul D W; Barnes, Chris P; Toni, Tina; Stumpf, Michael P H

    2014-06-01

    Experimental design attempts to maximise the information available for modelling tasks. An optimal experiment allows the inferred models or parameters to be chosen with the highest expected degree of confidence. If the true system is faithfully reproduced by one of the models, the merit of this approach is clear - we simply wish to identify it and the true parameters with the most certainty. However, in the more realistic situation where all models are incorrect or incomplete, the interpretation of model selection outcomes and the role of experimental design needs to be examined more carefully. Using a novel experimental design and model selection framework for stochastic state-space models, we perform high-throughput in-silico analyses on families of gene regulatory cascade models, to show that the selected model can depend on the experiment performed. We observe that experimental design thus makes confidence a criterion for model choice, but that this does not necessarily correlate with a model's predictive power or correctness. Finally, in the special case of linear ordinary differential equation (ODE) models, we explore how wrong a model has to be before it influences the conclusions of a model selection analysis.

  14. Applications of Chemiluminescence in the Teaching of Experimental Design

    Science.gov (United States)

    Krawczyk, Tomasz; Slupska, Roksana; Baj, Stefan

    2015-01-01

    This work describes a single-session laboratory experiment devoted to teaching the principles of factorial experimental design. Students undertook the rational optimization of a luminol oxidation reaction, using a two-level experiment that aimed to create a long-lasting bright emission. During the session students used only simple glassware and…

  15. Statistiscal Experimental Design for Quantitative Atomic Resolution Transmission Electron Microscopy

    NARCIS (Netherlands)

    Van Aert, S.

    2003-01-01

    Statistical experimental design is applied to set up quantitative atomic resolution transmission electron microscopy experiments. In such experiments, observations of the atomic structure of the object under study are always subject to spontaneous fluctuations. As a result of these fluctuations, the

  16. Using experimental designs to understand the development of peer relations

    NARCIS (Netherlands)

    Orobio De Castro, Bram; Thomaes, Sander; Reijntjes, Albert

    2015-01-01

    In the past decades, tremendous advances have been made in our understanding of peer relations. A description is emerging of how peer relations develop. Surprisingly, though, we know less about why peer relations develop as they do. Experimental designs provide opportunities to learn about causal pr

  17. Taguchi method of experimental design in materials education

    Science.gov (United States)

    Weiser, Martin W.

    1993-01-01

    Some of the advantages and disadvantages of the Taguchi Method of experimental design as applied to Materials Science will be discussed. This is a fractional factorial method that employs the minimum number of experimental trials for the information obtained. The analysis is also very simple to use and teach, which is quite advantageous in the classroom. In addition, the Taguchi loss function can be easily incorporated to emphasize that improvements in reproducibility are often at least as important as optimization of the response. The disadvantages of the Taguchi Method include the fact that factor interactions are normally not accounted for, there are zero degrees of freedom if all of the possible factors are used, and randomization is normally not used to prevent environmental biasing. In spite of these disadvantages it is felt that the Taguchi Method is extremely useful for both teaching experimental design and as a research tool, as will be shown with a number of brief examples.

  18. Optimal Experimental Design for Large-Scale Bayesian Inverse Problems

    KAUST Repository

    Ghattas, Omar

    2014-01-06

    We develop a Bayesian framework for the optimal experimental design of the shock tube experiments which are being carried out at the KAUST Clean Combustion Research Center. The unknown parameters are the pre-exponential parameters and the activation energies in the reaction rate expressions. The control parameters are the initial mixture composition and the temperature. The approach is based on first building a polynomial based surrogate model for the observables relevant to the shock tube experiments. Based on these surrogates, a novel MAP based approach is used to estimate the expected information gain in the proposed experiments, and to select the best experimental set-ups yielding the optimal expected information gains. The validity of the approach is tested using synthetic data generated by sampling the PC surrogate. We finally outline a methodology for validation using actual laboratory experiments, and extending experimental design methodology to the cases where the control parameters are noisy.

  19. Design and Experimental Research on a New Pipe Rupture Valve

    Institute of Scientific and Technical Information of China (English)

    HU Guo-liang; XU Bing; YANG Hua-yong; ZHANG Yi-ding

    2006-01-01

    A new pipe rupture valve for hydraulic elevator is designed.Mathematical models established for the hydraulic elevator system are used in numefical simulations on the Simulink environment of Matlab kits.The effects of different viscous damping diameters.inlet pressures of pipe rupture valve.and elevator loads on the hydraulic elevator system's dynamic performance are analyzed.Expefimenml research is also carried out using a hydraulic elevator experiment rig.The numerical simulations accord with experimental results in general.Dynamic performance indexes are assessed by the EN812 standard.The results show that the newly designed pipe rupture valve meets the designing requirement for hydraulic elevators.

  20. Designing Technology for Active Spectator Experiences at Sporting Events

    DEFF Research Database (Denmark)

    Veerasawmy, Rune; Ludvigsen, Martin

    2010-01-01

    behaviour in the context. The work presented also argues for a need to overcome the inclination to designing technological systems that imitate or compete with the experience of watching the television broadcast of the game. Experiments such as the presented BannerBattle are cornerstones in our exploratory......This paper explores the active spectator experience at sporting events, by presenting and reflecting upon a design experiment carried out at a number of football1 events. The initial hypothesis of the design process, leading to the design experiment has been that the spectator experience...... research-through-design approach to designing technologies for social experiences....

  1. New Perspectives: Technology Teacher Education and Engineering Design

    OpenAIRE

    Hill, Roger B.

    2006-01-01

    Initiatives to integrate engineering design within the field of technology education are increasingly evident (Lewis, 2005; Wicklein, 2006). Alliances between technology education and engineering were prominent in the development of the Standards for Technological Literacy (International Technology Education Association, 2000), and leaders from both disciplines have expressed support for the outcomes described in the Standards (Bybee, 2000; Council of the National Academy of Engineering, 2000...

  2. Computational design and experimental validation of new thermal barrier systems

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Shengmin [Louisiana State Univ., Baton Rouge, LA (United States)

    2015-03-31

    The focus of this project is on the development of a reliable and efficient ab initio based computational high temperature material design method which can be used to assist the Thermal Barrier Coating (TBC) bond-coat and top-coat design. Experimental evaluations on the new TBCs are conducted to confirm the new TBCs’ properties. Southern University is the subcontractor on this project with a focus on the computational simulation method development. We have performed ab initio density functional theory (DFT) method and molecular dynamics simulation on screening the top coats and bond coats for gas turbine thermal barrier coating design and validation applications. For experimental validations, our focus is on the hot corrosion performance of different TBC systems. For example, for one of the top coatings studied, we examined the thermal stability of TaZr2.75O8 and confirmed it’s hot corrosion performance.

  3. Development of core design technology for LMR

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Young Jin; Kim Young In; Kim, Young Il; Kim, Y. G.; Kim, S. J.; Song, H.; Kim, T. K.; Kim, W. S.; Hwang, W.; Lee, B. O.; Park, C. K.; Joo, H. K.; Yoo, J. W.; Kang, H. Y.; Park, W. S

    2000-05-01

    For the development of KALIMER (150 MWe) core conceptual design, design evolution and optimization for improved economics and safety enhancement was performed in the uranium metallic fueled equilibrium core design which uses U-Zr binary fuel not in excess of 20 percent enrichment. Utilizing results of the uranium ,metallic fueled core design, the breeder equilibrium core design with breeding ratio being over 1.1 was developed. In addition, utilizing LMR's excellent neutron economy, various core concepts for minor actinide burnup, inherent safety, economics and non-proliferation were realized and its optimization studies were performed. A code system for the LMR core conceptual design has been established through the implementation of needed functions into the existing codes and development of codes. To improve the accuracy of the core design, a multi-dimensional nodal transport code SOLTRAN, a three-dimensional transient code analysis code STEP, MATRA-LMR and ASSY-P for T/H analysis are under development. Through the automation of design calculations for efficient core design, an input generator and several interface codes have been developed. (author)

  4. Robot technologies, autism and designs for learning

    DEFF Research Database (Denmark)

    Hansbøl, Mikala

    2015-01-01

    in the future, with a focus on children and young people diagnosed with autism spectrum disorders, their ICT interests and engagement in innovative and creative learning. The paper draws on international research and examples from the author’s own research into education for children and young people diagnosed...... technologies involves several very different educational approaches to supporting young people’s learning and development. The paper discusses how robot technologies as learning resources have been related to the field of autism and education, and argues for a need to further expand the areas of application...... with autism spectrum disorders, drawing on teachers’ and the students’ interests in working with ICT (e.g. robot technology)....

  5. Convergence in parameters and predictions using computational experimental design.

    Science.gov (United States)

    Hagen, David R; White, Jacob K; Tidor, Bruce

    2013-08-06

    Typically, biological models fitted to experimental data suffer from significant parameter uncertainty, which can lead to inaccurate or uncertain predictions. One school of thought holds that accurate estimation of the true parameters of a biological system is inherently problematic. Recent work, however, suggests that optimal experimental design techniques can select sets of experiments whose members probe complementary aspects of a biochemical network that together can account for its full behaviour. Here, we implemented an experimental design approach for selecting sets of experiments that constrain parameter uncertainty. We demonstrated with a model of the epidermal growth factor-nerve growth factor pathway that, after synthetically performing a handful of optimal experiments, the uncertainty in all 48 parameters converged below 10 per cent. Furthermore, the fitted parameters converged to their true values with a small error consistent with the residual uncertainty. When untested experimental conditions were simulated with the fitted models, the predicted species concentrations converged to their true values with errors that were consistent with the residual uncertainty. This paper suggests that accurate parameter estimation is achievable with complementary experiments specifically designed for the task, and that the resulting parametrized models are capable of accurate predictions.

  6. Methodology and Technology for Design to Cost

    Institute of Scientific and Technical Information of China (English)

    姜华; 曾庆良; 熊光楞

    2001-01-01

    Product cost is one of the most important factors affectingproduct market share. Traditionally, product costs are estimated after they are manufactured. However, in this way, the best opportunity to control product cost is lost. In this paper, a method trying to reduce product cost at the design stage is proposed. This method is called Design to Cost (DTC). According to this method, product structure can be optimized with the application of value engineering and Design for Manufacturing/Assembly (DFMA) criteria in the conceptual stage of product design. During embodiment design, products are evaluated economically on the basis of the product model which includes manufacturing, assembly and test cost information. According to the results, products are redesigned before manufacture, and the production cost is reduced.

  7. Lab-Scale Fiber Spinning Experimental Design Cost Comparison

    Directory of Open Access Journals (Sweden)

    Jeffrey C. Moreland

    2010-03-01

    Full Text Available Many statistical experimental designs are too costlyor require too much raw material to be feasible forlab-scale fiber spinning experiments. In this study afour-factor response surface design is presented tostudy the fiber spinning process in detail at the labscale. The time, cost, and amount of raw materialrequired to execute the proposed design are comparedto the typical completely randomized 24 factorialdesign used in fiber spinning experiments and also toa standard four-factor response surface design.Sample fiber data as well as analysis from a typicalstatistical software package is provided to furtherdemonstrate the differences between each design. Bydesignating some treatment factors in the design ashard-to-change, split-plotting is used to reduce thetime, cost, and amount of raw material required tocomplete the experiment. The proposed split-plotdesign is faster and less expensive than a typicalfactorial design and has the advantage of fitting amore complex second-order model to the system.When compared to a standard response surfacedesign, the proposed split-plot design provides thesame second-order modeling capabilities but reducesthe cost of the experiment by 53%, the total time by36%, and the amount of polymer required by 24%.Thus, a split-plot response surface design based onhard-to-change factors is recommended in lab-scalespinning.

  8. Circuit design in organic semiconductor technologies

    NARCIS (Netherlands)

    Heremans, P.; Dehaene, W.; Steyaert, M.; Myny, K.; Mariën, H.; Genoe, J.; Gelinck, G.H.; Veenendaal, E. van

    2011-01-01

    In this paper, we review the state of the art of digital and analog circuits that have been shown in recent years in organic thin-film transistor technology on flexible plastic foil. The transistors are developed for backplanes of displays, and therefore have the characteristics to be unipolar and t

  9. Designing a new MSA biodiesel technology MBT

    Energy Technology Data Exchange (ETDEWEB)

    Ingendoh, Axel [Lanxess Deutschland GmbH, Leverkusen (Germany)

    2013-06-01

    The new MBT Technology was developed at Lanxess and eliminates all these constraints of the alkaline transesterification technology. The acidic transesterification uses Methane sulfonic acid catalysis. Due to the acidic nature of the MBT process formation of soaps is made impossible, sterylglycosides are completely cleaved into soluble product, free fatty acids up to 10% are tolerated, higher alcohols like ethanol and butanol do react equally well and waxes are completely converted into biodiesel. Phase separation of biodiesel and glycerol is dramatically enhanced due to the lack of methanol in this stage. Surprisingly, even water up to 5% does not affect the overall yield and product quality of the MBT Process. Cost savings in biodiesel production may be achieved by using low quality oils with high free fatty acids, use of algae oil, and cost savings at oil raffination due to no need of drying. The Technology is lean and requires less apparatus and less operational steps. The catalyst may be completely recycled by recovering it from the glycerol phase using Lewatit ion exchange technology of Lanxess. (orig.)

  10. Designing Personalization in Technology-Based Services

    Science.gov (United States)

    Lee, Min Kyung

    2013-01-01

    Personalization technology has the potential to optimize service for each person's unique needs and characteristics. One way to optimize service is to allow people to customize the service themselves; another is to proactively tailor services based on information provided by people or inferred from their past behaviors. These approaches function…

  11. Teacher and Technology, New Designs for Learning.

    Science.gov (United States)

    Trow, William Clark

    Technological devices present a challenge that educators cannot afford to ignore. Properly incorporated into a controlled environment, these tools need not bring about any dehumanization of the schools. Traditional teaching methods, promotion policies, marking practices, and classrooms organized by grade level may allow control over what is…

  12. Experimental design for parameter estimation of gene regulatory networks.

    Directory of Open Access Journals (Sweden)

    Bernhard Steiert

    Full Text Available Systems biology aims for building quantitative models to address unresolved issues in molecular biology. In order to describe the behavior of biological cells adequately, gene regulatory networks (GRNs are intensively investigated. As the validity of models built for GRNs depends crucially on the kinetic rates, various methods have been developed to estimate these parameters from experimental data. For this purpose, it is favorable to choose the experimental conditions yielding maximal information. However, existing experimental design principles often rely on unfulfilled mathematical assumptions or become computationally demanding with growing model complexity. To solve this problem, we combined advanced methods for parameter and uncertainty estimation with experimental design considerations. As a showcase, we optimized three simulated GRNs in one of the challenges from the Dialogue for Reverse Engineering Assessment and Methods (DREAM. This article presents our approach, which was awarded the best performing procedure at the DREAM6 Estimation of Model Parameters challenge. For fast and reliable parameter estimation, local deterministic optimization of the likelihood was applied. We analyzed identifiability and precision of the estimates by calculating the profile likelihood. Furthermore, the profiles provided a way to uncover a selection of most informative experiments, from which the optimal one was chosen using additional criteria at every step of the design process. In conclusion, we provide a strategy for optimal experimental design and show its successful application on three highly nonlinear dynamic models. Although presented in the context of the GRNs to be inferred for the DREAM6 challenge, the approach is generic and applicable to most types of quantitative models in systems biology and other disciplines.

  13. Optimizing an experimental design for an electromagnetic experiment

    Science.gov (United States)

    Roux, Estelle; Garcia, Xavier

    2013-04-01

    Most of geophysical studies focus on data acquisition and analysis, but another aspect which is gaining importance is the discussion on acquisition of suitable datasets. This can be done through the design of an optimal experiment. Optimizing an experimental design implies a compromise between maximizing the information we get about the target and reducing the cost of the experiment, considering a wide range of constraints (logistical, financial, experimental …). We are currently developing a method to design an optimal controlled-source electromagnetic (CSEM) experiment to detect a potential CO2 reservoir and monitor this reservoir during and after CO2 injection. Our statistical algorithm combines the use of linearized inverse theory (to evaluate the quality of one given design via the objective function) and stochastic optimization methods like genetic algorithm (to examine a wide range of possible surveys). The particularity of our method is that it uses a multi-objective genetic algorithm that searches for designs that fit several objective functions simultaneously. One main advantage of this kind of technique to design an experiment is that it does not require the acquisition of any data and can thus be easily conducted before any geophysical survey. Our new experimental design algorithm has been tested with a realistic one-dimensional resistivity model of the Earth in the region of study (northern Spain CO2 sequestration test site). We show that a small number of well distributed observations have the potential to resolve the target. This simple test also points out the importance of a well chosen objective function. Finally, in the context of CO2 sequestration that motivates this study, we might be interested in maximizing the information we get about the reservoir layer. In that case, we show how the combination of two different objective functions considerably improve its resolution.

  14. Reactor and process design in sustainable energy technology

    CERN Document Server

    Shi, Fan

    2014-01-01

    Reactor Process Design in Sustainable Energy Technology compiles and explains current developments in reactor and process design in sustainable energy technologies, including optimization and scale-up methodologies and numerical methods. Sustainable energy technologies that require more efficient means of converting and utilizing energy can help provide for burgeoning global energy demand while reducing anthropogenic carbon dioxide emissions associated with energy production. The book, contributed by an international team of academic and industry experts in the field, brings numerous reactor design cases to readers based on their valuable experience from lab R&D scale to industry levels. It is the first to emphasize reactor engineering in sustainable energy technology discussing design. It provides comprehensive tools and information to help engineers and energy professionals learn, design, and specify chemical reactors and processes confidently. Emphasis on reactor engineering in sustainable energy techn...

  15. Designing Teaching Materials for Learning Problem Solving in Technology Education

    NARCIS (Netherlands)

    Doornekamp, B.G.

    2001-01-01

    In the process of designing teaching materials for learning problem solving in technology education, domain-specific design specifications are considered important elements to raise learning outcomes with these materials. Two domain-specific design specifications were drawn up using a four-step proc

  16. Designing Teaching Materials for Learning Problem Solving in Technology Education

    NARCIS (Netherlands)

    Doornekamp, B.G.

    2001-01-01

    In the process of designing teaching materials for learning problem solving in technology education, domain-specific design specifications are considered important elements to raise learning outcomes with these materials. Two domain-specific design specifications were drawn up using a four-step proc

  17. Designing Teaching Materials for Learning Problem Solving in Technology Education

    NARCIS (Netherlands)

    Doornekamp, B.G.

    In the process of designing teaching materials for learning problem solving in technology education, domain-specific design specifications are considered important elements to raise learning outcomes with these materials. Two domain-specific design specifications were drawn up using a four-step

  18. Communications technology satellite output-tube design and development

    Science.gov (United States)

    Connolly, D. J.; Forman, R.; Jones, C. L.; Kosmahl, H.; Sharp, G. R.

    1977-01-01

    The design and development of a 200-watt-output, traveling-wave tube (TWT) for the Communications Technology Satellite (CTS) is discussed, with emphasis on the design evolution during the manufacturing phase of the development program. Possible further improvements to the tube design are identified.

  19. Robot technologies, autism and designs for learning

    DEFF Research Database (Denmark)

    Hansbøl, Mikala

    2015-01-01

    in the future, with a focus on children and young people diagnosed with autism spectrum disorders, their ICT interests and engagement in innovative and creative learning. The paper draws on international research and examples from the author’s own research into education for children and young people diagnosed...... with autism spectrum disorders, drawing on teachers’ and the students’ interests in working with ICT (e.g. robot technology)....... on Scandinavian schools places robotics and programming within a four to five year time-to-adoption period. At the moment in Denmark, many municipalities are initiating trials, investing in and engaging a diverse range of robot technologies in both daycare and schools. The field of education and robot...

  20. Memory Technologies and Data Recorder Design

    Science.gov (United States)

    Strauss, Karl F

    2009-01-01

    Missions, both near Earth and deep space, are under consideration that will require data recorder capacities of such magnitude as to be unthinkable just a few years ago. Concepts requiring well over 16,000 GB of storage are being studied. To achieve this capacity via "normal means" was considered incredible as recently as 2004. This paper is presented in two parts. Part I describes the analysis of data recorder capacities for missions as far back as 35 years and provides a projection of data capacities required 20 years from now based upon missions either nearing launch, or in the planning stage. The paper presents a similar projection of memory device capacities as baselined in the ITRS - the International Technology Roadmap for Semiconductors. Using known Total Ionizing Dose tolerance going back as far as a decade, a projection of total dose tolerance is made for two prime technologies out to the year 2028.

  1. Model Development and Experimental Validation of the Fusible Heat Sink Design for Exploration Vehicles

    Science.gov (United States)

    Cognata, Thomas J.; Leimkuehler, Thomas; Sheth, Rubik; Le, Hung

    2013-01-01

    The Fusible Heat Sink is a novel vehicle heat rejection technology which combines a flow through radiator with a phase change material. The combined technologies create a multi-function device able to shield crew members against Solar Particle Events (SPE), reduce radiator extent by permitting sizing to the average vehicle heat load rather than to the peak vehicle heat load, and to substantially absorb heat load excursions from the average while constantly maintaining thermal control system setpoints. This multi-function technology provides great flexibility for mission planning, making it possible to operate a vehicle in hot or cold environments and under high or low heat load conditions for extended periods of time. This paper describes the modeling and experimental validation of the Fusible Heat Sink technology. The model developed was intended to meet the radiation and heat rejection requirements of a nominal MMSEV mission. Development parameters and results, including sizing and model performance will be discussed. From this flight-sized model, a scaled test-article design was modeled, designed, and fabricated for experimental validation of the technology at Johnson Space Center thermal vacuum chamber facilities. Testing showed performance comparable to the model at nominal loads and the capability to maintain heat loads substantially greater than nominal for extended periods of time.

  2. Advanced technologies in web application design

    OpenAIRE

    Peruš, Blaž

    2016-01-01

    The main goal of this diploma thesis is a presentation of Autocommerce web project development. All used technologies are described. On the basis of the project we also present agile methodologies for software development which helps us to efficiently build the whole information system from the idea to the first version. Such methodologies are mostly used by startups, because they are perfect for building and testing products in a very short time & for adapting with the provided feedback from...

  3. The power of design product innovation in sustainable energy technologies

    CERN Document Server

    Reinders, Angele H; Brezet, Han

    2012-01-01

    The Power of Design offers an introduction and a practical guide to product innovation, integrating the key topics that are necessary for the design of sustainable and energy-efficient products using sustainable energy technologies. Product innovation in sustainable energy technologies is an interdisciplinary field. In response to its growing importance and the need for an integrated view on the development of solutions, this text addresses the functional principles of various energy technologies next to the latest design processes and innovation methods. From the perspec

  4. Development of MMIS design technology for integral reactor

    Energy Technology Data Exchange (ETDEWEB)

    Koo, In Soo; Park, H. Y.; Lee, C. K. and others

    1999-03-01

    The objective of this study is to establish the concept design of the SMART MMIS through the setup of a structure and design concept of MMIS, the development of design methodology, and essential technologies for MMIS considering computer based digital technologies and human factors. Main activities of this study divided into three categories such as the development of conceptual design and requirement of the SMART I and C, the development of conceptual design and requirement of the SMART MMI, and essential technology for the MMIS. The results of main activities that have been performed during the study are as follows; 1) The review of licensing requirements and operating experience of existing plants. 2) The establishment of a system design concept about development strategy, basic functions and requirements, and applicable technology through the adoption of digital technology and human factorsengineering. 3) The accomplishment of function, structure, and design requirement of each MMIS through the performance of conceptual design on system structure and actuation logic using function analysis. It is necessary to develop and apply new technologies for the MMIS design compatible with the design basis of SMART. Considered essential technologies for the MMIS in this study are 1) the development of a signal validation algorithm and sensor diagnosis technique 2) the development of a soft controller for operator's action 3) the establishment of a data communication structure for MMIS architecture 4) the development of an information optimization basis and automatic start-up algorithm 5) the development of sensor reduction requirements 6) the development of a qualification method of digital equipment for applied digital technology and commercial grade items. (author)

  5. Future Technology Workshop: A Collaborative Method for the Design of New Learning Technologies and Activities

    Science.gov (United States)

    Vavoula, Giasemi N.; Sharples, Mike

    2007-01-01

    We describe the future technology workshop (FTW), a method whereby people with everyday knowledge or experience in a specific area of technology use (such as using digital cameras) envision and design the interactions between current and future technology and activity. Through a series of structured workshop sessions, participants collaborate to…

  6. Experimental design unified concepts, practical applications, and computer implementation

    CERN Document Server

    Bowerman, Bruce L

    2014-01-01

    This book is a concise and innovative book that gives a complete presentation of the design and analysis of experiments in approximately one half the space of competing books. With only the modest prerequisite of a basic (non-calculus) statistics course, this text is appropriate for the widest possible audience. Two procedures are generally used to analyze experimental design data-analysis of variance (ANOVA) and regression analysis. Because ANOVA is more intuitive, this book devotes most of its first three chapters to showing how to use ANOVA to analyze balanced (equal sample size) experiment

  7. Optimal active vibration absorber - Design and experimental results

    Science.gov (United States)

    Lee-Glauser, Gina; Juang, Jer-Nan; Sulla, Jeffrey L.

    1993-01-01

    An optimal active vibration absorber can provide guaranteed closed-loop stability and control for large flexible space structures with collocated sensors/actuators. The active vibration absorber is a second-order dynamic system which is designed to suppress any unwanted structural vibration. This can be designed with minimum knowledge of the controlled system. Two methods for optimizing the active vibration absorber parameters are illustrated: minimum resonant amplitude and frequency matched active controllers. The Controls-Structures Interaction Phase-1 Evolutionary Model at NASA LaRC is used to demonstrate the effectiveness of the active vibration absorber for vibration suppression. Performance is compared numerically and experimentally using acceleration feedback.

  8. Optimal active vibration absorber: Design and experimental results

    Science.gov (United States)

    Lee-Glauser, Gina; Juang, Jer-Nan; Sulla, Jeffrey L.

    1992-01-01

    An optimal active vibration absorber can provide guaranteed closed-loop stability and control for large flexible space structures with collocated sensors/actuators. The active vibration absorber is a second-order dynamic system which is designed to suppress any unwanted structural vibration. This can be designed with minimum knowledge of the controlled system. Two methods for optimizing the active vibration absorber parameters are illustrated: minimum resonant amplitude and frequency matched active controllers. The Controls-Structures Interaction Phase-1 Evolutionary Model at NASA LaRC is used to demonstrate the effectiveness of the active vibration absorber for vibration suppression. Performance is compared numerically and experimentally using acceleration feedback.

  9. TIBER: Tokamak Ignition/Burn Experimental Research. Final design report

    Energy Technology Data Exchange (ETDEWEB)

    Henning, C.D.; Logan, B.G.; Barr, W.L.; Bulmer, R.H.; Doggett, J.N.; Johnson, B.M.; Lee, J.D.; Hoard, R.W.; Miller, J.R.; Slack, D.S.

    1985-11-01

    The Tokamak Ignition/Burn Experimental Research (TIBER) device is the smallest superconductivity tokamak designed to date. In the design plasma shaping is used to achieve a high plasma beta. Neutron shielding is minimized to achieve the desired small device size, but the superconducting magnets must be shielded sufficiently to reduce the neutron heat load and the gamma-ray dose to various components of the device. Specifications of the plasma-shaping coil, the shielding, coaling, requirements, and heating modes are given. 61 refs., 92 figs., 30 tabs. (WRF)

  10. Fast Bayesian optimal experimental design and its applications

    KAUST Repository

    Long, Quan

    2015-01-07

    We summarize our Laplace method and multilevel method of accelerating the computation of the expected information gain in a Bayesian Optimal Experimental Design (OED). Laplace method is a widely-used method to approximate an integration in statistics. We analyze this method in the context of optimal Bayesian experimental design and extend this method from the classical scenario, where a single dominant mode of the parameters can be completely-determined by the experiment, to the scenarios where a non-informative parametric manifold exists. We show that by carrying out this approximation the estimation of the expected Kullback-Leibler divergence can be significantly accelerated. While Laplace method requires a concentration of measure, multi-level Monte Carlo method can be used to tackle the problem when there is a lack of measure concentration. We show some initial results on this approach. The developed methodologies have been applied to various sensor deployment problems, e.g., impedance tomography and seismic source inversion.

  11. Contract design and insurance fraud: An experimental investigation

    OpenAIRE

    Lammers, Frauke; Schiller, Jörg

    2010-01-01

    This paper investigates the impact of insurance contract design on the behavior of filing fraudulent claims in an experimental setup. We test how fraud behavior varies for insurance contracts with full coverage, a straight deductible or variable premiums (bonus-malus contract). In our experiment, filing fraudulent claims is a dominant strategy for selfish participants, with no psychological costs of committing fraud. While some people always commit fraud, a substantial share of people only oc...

  12. Experimental framework for autonomous fast ships's control design

    OpenAIRE

    Recas Piorno, Joaquín; Esteban San Román, Segundo; Girón Sierra, José María; Cruz García, Jesús Manuel de la

    2005-01-01

    The research on seakeeping control of fast ships requires difficult experiments for modeling and control design. To alleviate the ship motion certain active appendages are added, such moving flaps, T-foil and fins. The motion of appendages must be optimized to counteract each encountered wave. During our first research steps, a scaled down ship, with scaled appendages, has been used in a towing tank facility. The scaled ship is towed at fixed speeds of experimental interest, for instance at t...

  13. Gradient-based stochastic optimization methods in Bayesian experimental design

    OpenAIRE

    2012-01-01

    Optimal experimental design (OED) seeks experiments expected to yield the most useful data for some purpose. In practical circumstances where experiments are time-consuming or resource-intensive, OED can yield enormous savings. We pursue OED for nonlinear systems from a Bayesian perspective, with the goal of choosing experiments that are optimal for parameter inference. Our objective in this context is the expected information gain in model parameters, which in general can only be estimated u...

  14. Parameter Estimation and Experimental Design in Groundwater Modeling

    Institute of Scientific and Technical Information of China (English)

    SUN Ne-zheng

    2004-01-01

    This paper reviews the latest developments on parameter estimation and experimental design in the field of groundwater modeling. Special considerations are given when the structure of the identified parameter is complex and unknown. A new methodology for constructing useful groundwater models is described, which is based on the quantitative relationships among the complexity of model structure, the identifiability of parameter, the sufficiency of data, and the reliability of model application.

  15. Technology, design and dementia: an exploratory survey of developers.

    Science.gov (United States)

    Jiancaro, Tizneem; Jaglal, Susan B; Mihailidis, Alex

    2017-08-01

    Despite worldwide surges in dementia, we still know relatively little about the design of home technologies that support this population. The purpose of this study was to investigate design considerations from the perspective of developers. Participants, including technical and clinical specialists, were recruited internationally and answered web-based survey questions comprising Likert-type responses with text entry options. Developers were queried on 23 technology acceptance characteristics and 24 design practices. In all, forty developers completed the survey. Concerning "technology acceptance", cost, learnability, self-confidence (during use) and usability were deemed very important. Concerning "design practice", developers overwhelmingly valued user-centred design (UCD). In terms of general assistive technology (AT) models, these were largely unknown by technical specialists compared to clinical specialists. Recommendations based on this study include incorporating "self-confidence" into design protocols; examining the implications of "usability" and UCD in this context; and considering empathy-based design approaches to suit a diverse user population. Moreover, clinical specialists have much to offer development teams, particularly concerning the use of conceptual AT models. Implications of rehabilitation Stipulate precise usability criteria. Consider "learnability" and "self-confidence" as technology adoption criteria. Recognize the important theoretical role that clinical specialists can fulfil concerning the use of design schemas. Acknowledge the diversity amongst users with dementia, potentially adopting techniques, such as designing for "extraordinary users".

  16. Integrated plant information technology design support functionality

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yeon Seung; Kim, Dae Jin [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of); Barber, P. W.; Goland, D. [Atomic Energy Canada Ltd., (Canada)

    1996-06-01

    This technical report was written as a result of Integrated Plant Information System (IPIS) feasibility study on CANDU 9 project which had been carried out from January, 1994 to March, 1994 at AECL (Atomic Energy Canada Limited) in Canada. From 1987, AECL had done endeavour to change engineering work process from paper based work process to computer based work process through CANDU 3 project. Even though AECL had a lot of good results form computerizing the Process Engineering, Instrumentation Control and Electrical Engineering, Mechanical Engineering, Computer Aided Design and Drafting, and Document Management System, but there remains the problem of information isolation and integration. On this feasibility study, IPIS design support functionality guideline was suggested by evaluating current AECL CAE tools, analyzing computer aided engineering task and work flow, investigating request for implementing integrated computer aided engineering and describing Korean request for future CANDU design including CANDU 9. 6 figs. (Author).

  17. Technological design as an evolutionary process

    NARCIS (Netherlands)

    Brey, Philip; Kroes, Peter; Vermaas, Pieter E.; Light, Andrew; Moore, Steven A.

    2008-01-01

    The evolution of technical artifacts is often seen as radically different from the evolution of biological species. Technical artifacts are normally understood to result from the purposive intelligence of designers whereas biological species and organisms are held to have resulted from evolution by

  18. Technological design as an evolutionary process

    NARCIS (Netherlands)

    Brey, Philip A.E.; Kroes, Peter; Vermaas, Pieter E.; Light, Andrew; Moore, Steven A.

    2008-01-01

    The evolution of technical artifacts is often seen as radically different from the evolution of biological species. Technical artifacts are normally understood to result from the purposive intelligence of designers whereas biological species and organisms are held to have resulted from evolution by

  19. Permanent magnet motor technology design and applications

    CERN Document Server

    Gieras, Jacek F

    2009-01-01

    Demonstrates the construction of permanent magnet (PM) motor drives and supplies ready-to-implement solutions to common roadblocks along the way. This book also supplies fundamental equations and calculations for determining and evaluating system performance, efficiency, reliability, and cost. It explores modern computer-aided design of PM motors.

  20. Development of Information Technology of Object-relational Databases Design

    Directory of Open Access Journals (Sweden)

    Valentyn A. Filatov

    2012-12-01

    Full Text Available The article is concerned with the development of information technology of object-relational databases design and study of object features infological and logical database schemes entities and connections.

  1. Design for experience where technology meets design and strategy

    CERN Document Server

    Kim, Jinwoo

    2015-01-01

    Presents a strategic perspective and design methodology that guide the process of developing digital products and services that provide 'real experience' to users. Only when the material experienced runs its course to fulfilment is it then regarded as 'real experience' that is distinctively senseful, evaluated as valuable, and harmoniously related to others. Based on the theoretical background of human experience, the book focuses on these three questions: How can we understand the current dominant designs of digital products and services? What are the user experience factor

  2. Integrating Engineering Design into Technology Education: Georgia's Perspective

    Science.gov (United States)

    Denson, Cameron D.; Kelley, Todd R.; Wicklein, Robert C.

    2009-01-01

    This descriptive research study reported on Georgia's secondary level (grades 6-12) technology education programs capability to incorporate engineering concepts and/or engineering design into their curriculum. Participants were middle school and high school teachers in the state of Georgia who currently teach technology education. Participants…

  3. Bayesian Optimal Experimental Design Using Multilevel Monte Carlo

    KAUST Repository

    Issaid, Chaouki Ben

    2015-01-07

    Experimental design is very important since experiments are often resource-exhaustive and time-consuming. We carry out experimental design in the Bayesian framework. To measure the amount of information, which can be extracted from the data in an experiment, we use the expected information gain as the utility function, which specifically is the expected logarithmic ratio between the posterior and prior distributions. Optimizing this utility function enables us to design experiments that yield the most informative data for our purpose. One of the major difficulties in evaluating the expected information gain is that the integral is nested and can be high dimensional. We propose using Multilevel Monte Carlo techniques to accelerate the computation of the nested high dimensional integral. The advantages are twofold. First, the Multilevel Monte Carlo can significantly reduce the cost of the nested integral for a given tolerance, by using an optimal sample distribution among different sample averages of the inner integrals. Second, the Multilevel Monte Carlo method imposes less assumptions, such as the concentration of measures, required by Laplace method. We test our Multilevel Monte Carlo technique using a numerical example on the design of sensor deployment for a Darcy flow problem governed by one dimensional Laplace equation. We also compare the performance of the Multilevel Monte Carlo, Laplace approximation and direct double loop Monte Carlo.

  4. Hybrid microcircuit technology handbook materials, processes, design, testing and production

    CERN Document Server

    Licari, James J

    1998-01-01

    The Hybrid Microcircuit Technology Handbook integrates the many diverse technologies used in the design, fabrication, assembly, and testing of hybrid segments crucial to the success of producing reliable circuits in high yields. Among these are: resistor trimming, wire bonding, die attachment, cleaning, hermetic sealing, and moisture analysis. In addition to thin films, thick films, and assembly processes, important chapters on substrate selections, handling (including electrostatic discharge), failure analysis, and documentation are included. A comprehensive chapter of design guidelines will

  5. Development of mechanical structure design technology for LMR

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Bong; Lee, Jae Han; Joo, Young Sang [and others

    2000-05-01

    In this project, fundamentals for conceptual design of mechanical structure system for LMR are independently established. The research contents are as follow; at first, conceptual design for SSC, design integration of interfaces, design consistency to keep functions and interfaces by developing arrangement of reactor system and 3 dimensional concept drawings, development and revision of preliminary design requirements and structural design basis, and evaluation of structural integrity for SSC following structural design criteria to check the conceptual design to be proper, at second, development of high temperature structure design and analysis technology and establishment of high temperature structural analysis codes and scheme, development of seismic isolation design concept to reduce seismic design loads to SCC and establishment of seismic analysis codes and scheme.

  6. Theoretical and experimental performance analysis for cold trap design

    Energy Technology Data Exchange (ETDEWEB)

    Hemanath, M.G., E-mail: hemanath@igcar.gov.i [Fast Reactor Technology Group, Indira Gandhi Center for Atomic Research, Kalpakkam (India); Meikandamurthy, C.; Kumar, A. Ashok; Chandramouli, S.; Rajan, K.K.; Rajan, M.; Vaidyanathan, G.; Padmakumar, G.; Kalyanasundaram, P.; Raj, Baldev [Fast Reactor Technology Group, Indira Gandhi Center for Atomic Research, Kalpakkam (India)

    2010-10-15

    Cold trap is a purification unit used in sodium system of FBR's for maintaining the oxygen/hydrogen level in sodium within acceptable limits. It works on the principle of crystallization and precipitation of oxides/hydrides of sodium in a wire mesh, when the temperature of sodium is reduced below the saturation temperature. The cold traps presently used have lower effectiveness and get plugged prematurely. The plugged cold traps are cleaned and then put back into service. Frequent cleaning of cold trap results in the long down time of the sodium system. New design of cold trap has been conceived to overcome the above problems. The mathematical modeling for the new design was carried out and validated with experimentally tested results for its effectiveness. This paper shares the experience gained on the new design of cold trap for FBR's.

  7. Design and experimental study of a novel giant magnetostrictive actuator

    Science.gov (United States)

    Xue, Guangming; Zhang, Peilin; He, Zhongbo; Li, Dongwei; Huang, Yingjie; Xie, Wenqiang

    2016-12-01

    Giant magnetostrictive actuator has been widely used in precise driving occasions for its excellent performance. However, in driving a switching valve, especially the ball-valve in an electronic controlled injector, the actuator can't exhibit its good performance for limits in output displacement and responding speed. A novel giant magnetostrictive actuator, which can reach its maximum displacement for being exerted with no bias magnetic field, is designed in this paper. Simultaneously, elongating of the giant magetostrictive material is converted to shortening of the actuator's axial dimension with the help of an output rod in "T" type. Furthermore, to save responding time, the driving voltage with high opening voltage while low holding voltage is designed. Responding time and output displacement are studied experimentally with the help of a measuring system. From measured results, designed driving voltage can improve the responding speed of actuator displacement quite effectively. And, giant magnetostrictive actuator can output various steady-state displacements to reach more driving effects.

  8. Development of core design and analyses technology for integral reactor

    Energy Technology Data Exchange (ETDEWEB)

    Zee, Sung Quun; Lee, C. C.; Song, J. S. and others

    1999-03-01

    Integral reactors are developed for the applications such as sea water desalination, heat energy for various industries, and power sources for large container ships. In order to enhance the inherent and passive safety features, low power density concept is chosen for the integral reactor SMART. Moreover, ultra-longer cycle and boron-free operation concepts are reviewed for better plant economy and simple design of reactor system. Especially, boron-free operation concept brings about large difference in core configurations and reactivity controls from those of the existing large size commercial nuclear power plants and also causes many differences in the safety aspects. The ultimate objectives of this study include detailed core design of a integral reactor, development of the core design system and technology, and finally acquisition of the system design certificate. The goal of the first stage is the conceptual core design, that is, to establish the design bases and requirements suitable for the boron-free concept, to develop a core loading pattern, to analyze the nuclear, thermal and hydraulic characteristics of the core and to perform the core shielding design. Interface data for safety and performance analyses including fuel design data are produced for the relevant design analysis groups. Nuclear, thermal and hydraulic, shielding design and analysis code systems necessary for the core conceptual design are established through modification of the existing design tools and newly developed methodology and code modules. Core safety and performance can be improved by the technology development such as boron-free core optimization, advaned core monitoring and operational aid system. Feasiblity study on the improvement of the core protection and monitoring system will also contribute toward core safety and performance. Both the conceptual core design study and the related technology will provide concrete basis for the next design phase. This study will also

  9. Data Sharing of Mechanical Design Formulas Using Semantic Web Technology

    Science.gov (United States)

    Zhou, Jun; Watanuki, Keiichi

    Speed and efficiency are necessary in the field of mechanical design. CAD/CAM/CAE technologies have advanced and attention has also been paid to increasing the efficiency of data sharing and agent processes in the web environment. In this paper, Semantic Web technology is used to enable the sharing of metadata. The metadata consists of design documents and design formulas, with additional semantic information inserted. Mathematical information is expressed by adding metadata into conventional mechanical design formulas using a Resource Description Framework (RDF). The design formulas are later written in MathML (Mathematical Markup Language) for the sake of data sharing. In this way, data sharing and advanced searching is made easy, because the relevant information is made machine readable in the web environment. The calculation of design formulas is made possible using a mathematical processing system, thus increasing the efficiency of mechanical design.

  10. Design Research through the Lens of Sociology of Technology

    DEFF Research Database (Denmark)

    Berntsen, Hilde Østerås; Seim, Rikke

    2007-01-01

    The use of an approach to design research inspired by Sociology of Technology offers a nuanced understanding of design processes. The purpose of this paper is to explore how terminology derived from the socio-technical theory of Actor Network (ANT) can be used to understand the complexity of design......-design of existing workspace and work practice in an industrial company. The case study (i) illustrates a socio-technical approach to design research and (ii) shows how ANT terminology can be applied in an analysis of the course of events in a design process with numerous actors involved....

  11. Entropy-Based Search Algorithm for Experimental Design

    Science.gov (United States)

    Malakar, N. K.; Knuth, K. H.

    2011-03-01

    The scientific method relies on the iterated processes of inference and inquiry. The inference phase consists of selecting the most probable models based on the available data; whereas the inquiry phase consists of using what is known about the models to select the most relevant experiment. Optimizing inquiry involves searching the parameterized space of experiments to select the experiment that promises, on average, to be maximally informative. In the case where it is important to learn about each of the model parameters, the relevance of an experiment is quantified by Shannon entropy of the distribution of experimental outcomes predicted by a probable set of models. If the set of potential experiments is described by many parameters, we must search this high-dimensional entropy space. Brute force search methods will be slow and computationally expensive. We present an entropy-based search algorithm, called nested entropy sampling, to select the most informative experiment for efficient experimental design. This algorithm is inspired by Skilling's nested sampling algorithm used in inference and borrows the concept of a rising threshold while a set of experiment samples are maintained. We demonstrate that this algorithm not only selects highly relevant experiments, but also is more efficient than brute force search. Such entropic search techniques promise to greatly benefit autonomous experimental design.

  12. RF MEMS theory, design, and technology

    CERN Document Server

    Rebeiz, Gabriel M

    2003-01-01

    Ultrasmall Radio Frequency and Micro-wave Microelectromechanical systems (RF MEMs), such as switches, varactors, and phase shifters, exhibit nearly zero power consumption or loss. For this reason, they are being developed intensively by corporations worldwide for use in telecommunications equipment. This book acquaints readers with the basics of RF MEMs and describes how to design practical circuits and devices with them. The author, an acknowledged expert in the field, presents a range of real-world applications and shares many valuable tricks of the trade.

  13. IUTAM Symposium on Nonlinear Dynamics for Advanced Technologies and Engineering Design

    CERN Document Server

    Rega, Giuseppe

    2013-01-01

    Nonlinear dynamics has been enjoying a vast development for nearly four decades resulting in a range of well established theory, with the potential to significantly enhance performance, effectiveness, reliability and safety of physical systems as well as offering novel technologies and designs. By critically appraising the state-of-the-art, it is now time to develop design criteria and technology for new generation products/processes operating on principles of nonlinear interaction and in the nonlinear regime, leading to more effective, sensitive, accurate, and durable methods than what is currently available. This new approach is expected to radically influence the design, control and exploitation paradigms, in a magnitude of contexts. With a strong emphasis on experimentally calibrated and validated models, contributions by top-level international experts will foster future directions for the development of engineering technologies and design using robust nonlinear dynamics modelling and analysis.  

  14. Toward a Theory for the Design of Human Technologies

    DEFF Research Database (Denmark)

    Simonsen, Jesper; Hertzum, Morten; Nielsen, Jørgen Lerche;

    2014-01-01

    Design is increasingly becoming a part of the university curriculum and research agenda. A theory about the pro-cess and practice of design might be important to estab-lish design as a main subject at universities. We believe it is in the interest of many design communities – not least...... the Participatory Design (PD) community – to engage in theorizing design, on the basis of our understanding of design and design practices. This theory could be posi-tioned as an alternative to other attempts to theorize design, for example the influential efforts of the Information Systems (IS) community. We urge...... the PD community to engage in collective theory building, and we present a framework intended to support our shared reflections on the design of human technologies....

  15. Wiki Technology as a Design Tool for a Capstone Design Course

    Science.gov (United States)

    Hadley, Kevin R.; Debelak, Kenneth A.

    2009-01-01

    Technology is a key component to the net generation's social, study, and professional skills. It is prudent to investigate the applications of new technology in education. In this study, a wiki was incorporated into a senior design course, and its utility was investigated with respect to process design. The results of the study indicate wikis…

  16. Technology Route and System Design of Green IT

    Science.gov (United States)

    Hou, Juchi; Liang, Ying; Wei, Jianli

    Green IT is new route of reducing energy consuming and lessening discharging of greenhouse gas. In this paper, we design a technology route for implementing of Green IT. The technology route depends on the coordination of two kinds of relation: firstly, IT manufacturers must adopt advanced technology route. IT manufacturers should use materials of environment protection to produce computers and developing IT technology of energy-saving to make computers be environmental friendly. Secondly, the related ones in the whole society should appeal for system design of Green IT. Governments and related sides should draw up evaluation indexes of Green IT products and raise the awareness of using Green IT products. A comprehensive framework for Green IT technology route is proposed, which provides a foundation for further study.

  17. The Application of Computer Technology in Art Design

    Directory of Open Access Journals (Sweden)

    Tao Xin

    2016-01-01

    Full Text Available After entering the twenty-first Century, computer technology has been greatly developed, applied in various fields gradually, and gained remarkable achievement. Computer technology not only is a project of great importance in China, but also cannot be ignored in the world. It has already attracted attention of numerous people, gradually integrated in daily life and closely related with it. Now how to apply it into more fields has been the main focus of our nation and also the topic we care about all the time. It is also an important project in our country to apply computer technology in art design in order to higher the art design quality. The purpose of this paper is to introduce people problems of the application of computer technology in art design, and find ways to promote cooperation and common development of them.

  18. User-centric technology design for nonprofit and civic engagements

    CERN Document Server

    Saeed, Saqib

    2014-01-01

    Due to the increased global political importance of the nonprofit sector, its technological support and organizational characteristics have become important fields of research. In order to conduct effective work, nonprofits need to communicate and coordinate effectively. However, such settings are generally characterized by a lack of resources, an absence of formal hierarchical structures and differences in languages and culture among the activists. Modern technologies could help nonprofit networks in improving their working. In order to design appropriate technological support for such settings, it is important to understand their work practices, which widely differ from traditional business organizations. This book aims to strengthen the body of knowledge by providing user studies and concepts related to user centered technology design process for nonprofit settings. The examination of ethnographic studies and user centered evaluation of IT artifacts in practice will further the understanding of design requ...

  19. Entropy-Based Search Algorithm for Experimental Design

    CERN Document Server

    Malakar, N K

    2010-01-01

    The scientific method relies on the iterated processes of inference and inquiry. The inference phase consists of selecting the most probable models based on the available data; whereas the inquiry phase consists of using what is known about the models to select the most relevant experiment. Optimizing inquiry involves searching the parameterized space of experiments to select the experiment that promises, on average, to be maximally informative. In the case where it is important to learn about each of the model parameters, the relevance of an experiment is quantified by Shannon entropy of the distribution of experimental outcomes predicted by a probable set of models. If the set of potential experiments is described by many parameters, we must search this high-dimensional entropy space. Brute force search methods will be slow and computationally expensive. We present an entropy-based search algorithm, called nested entropy sampling, to select the most informative experiment for efficient experimental design. ...

  20. Design characteristics and requirements of irradiation holes for research reactor experimental facilities

    Energy Technology Data Exchange (ETDEWEB)

    Park, Cheol; Lee, B. C.; Chae, H. T.; Lee, C. S.; Seo, C. G

    2003-07-01

    In order to be helpful for the design of a new research reactor with high performance, are summarized the applications of research reactors in various fields and the design characteristics of experimental facility such as vertical irradiation holes and beam tubes. Basic requirements of such experimental facilities are also described. Research reactor has been widely utilized in various fields such as industry, engineering, medicine, life science, environment etc., and now the application fields are gradually being expanded together with the development of technology. Looking into the research reactors which are recently constructed or in plan, it seems that to develop a multi-purpose research reactor with intensive neutron beam research capability has become tendency. In the layout of the experimental facilities, the number and configuration of irradiation and beam holes should be optimized to meet required test conditions such as neutron flux at the early design stage. But, basically high neutron flux is required to perform experiments efficiently. In this aspect, neutron flux is regarded as one of important parameters to judge the degree of research reactor performance. One of main information for a new research reactor design is utilization demands and requirements of experimental holes. So basic requirements which should be considered in a new research reactor design were summarized from the survey of experimental facilities characteristics of various research reactors with around 20 MW thermal power and the experiences of HANARO utilization. Also is suggested an example of the requirements of experimental holes such as size, number and neutron flux, which are thought as minimum, in a new research reactor for exporting to developing countries such as Vietnam.

  1. DESIGNING ROADS IN GRENLAND USING GIS TECHNOLOGY

    Directory of Open Access Journals (Sweden)

    Abdel A.Z. Barten

    2015-01-01

    Full Text Available Designing a road in the Arctic (Greenland which stretches 157 km between the towns of Sisimiut and Kangerlussuaq was very challenging. Difficult climatic and geotechnical conditions and presence of permafrost required some in-depth analysis and research. Geotechnical investigations were conducted along the entire route. The investigations included field geological and geophysical studies and survey using aerial photography.Based on the investigations a digital model of the area 2 km Ѕ 170 km was prepared. Using a Novapoint software a detailed geometric model was created which allowed for calculationsof the volume of earthworks and creation of transverse and longitudinal sections of the road. A virtual model of the entire road and a movie were made based on the results of all investigations.

  2. Acting like a physicist: Student approach study to experimental design

    Science.gov (United States)

    Karelina, Anna; Etkina, Eugenia

    2007-12-01

    National studies of science education have unanimously concluded that preparing our students for the demands of the 21st century workplace is one of the major goals. This paper describes a study of student activities in introductory college physics labs, which were designed to help students acquire abilities that are valuable in the workplace. In these labs [called Investigative Science Learning Environment (ISLE) labs], students design their own experiments. Our previous studies have shown that students in these labs acquire scientific abilities such as the ability to design an experiment to solve a problem, the ability to collect and analyze data, the ability to evaluate assumptions and uncertainties, and the ability to communicate. These studies mostly concentrated on analyzing students’ writing, evaluated by specially designed scientific ability rubrics. Recently, we started to study whether the ISLE labs make students not only write like scientists but also engage in discussions and act like scientists while doing the labs. For example, do students plan an experiment, validate assumptions, evaluate results, and revise the experiment if necessary? A brief report of some of our findings that came from monitoring students’ activity during ISLE and nondesign labs was presented in the Physics Education Research Conference Proceedings. We found differences in student behavior and discussions that indicated that ISLE labs do in fact encourage a scientistlike approach to experimental design and promote high-quality discussions. This paper presents a full description of the study.

  3. Recognizing and Fostering Creativity in Technological Design Education

    Science.gov (United States)

    Cropley, David; Cropley, Arthur

    2010-01-01

    The importance of creativity in technological design education is now clearly recognized, both in everyday understanding and also in formal curriculum guidelines. Design offers special opportunities for creativity because of the "openness" of problems (ill-defined problems, the existence of a variety of pathways to the solution, the absence of…

  4. Developments in Participatory Design of Health Information Technology

    DEFF Research Database (Denmark)

    Madsen, Jacob

    2017-01-01

    The landscape of Participatory Design (PD) of Health Information Technology (HIT) is diverse and constantly evolving. This paper reviews the publications in the proceedings from the Participatory Design Conferences (PDCs) that have been held every two years since 1990. We used the Matrix Method...

  5. Teacher Challenges to Implement Engineering Design in Secondary Technology Education

    Science.gov (United States)

    Kelley, Todd R.; Wicklein, Robert C.

    2009-01-01

    This descriptive study examined the current status of technology education teacher practices with respect to engineering design. This article is the third article in a three-part series presenting the results of this study. The first article in the series titled "Examination of Engineering Design Curriculum Content" highlighted the research…

  6. Co-Simulation Technology for Complex Product Design

    Institute of Scientific and Technical Information of China (English)

    熊光楞; 陈小波; 郭滨; 蹇佳; 王成龙

    2002-01-01

    First analyze the simulation requirements in complex product design, then propose the approach to full applying simulation to complex product design, and present the key enable technology with respect to modeling, simulation running, VV&A,evaluation and decision making and supporting platform.

  7. Design and Technology and the Challenge of Refugee Children.

    Science.gov (United States)

    MacPhee, Susan

    2000-01-01

    A resource designed to introduce design and technology to refugee students for whom English is an additional language uses graphics to help explain tasks. As a standalone resource, it can be used at any time during the year and it can be varied to suit students' abilities. (SK)

  8. REVIEW: Trends And Issues In Instructional Design And Technology

    OpenAIRE

    AKBULUT, Reviewed By Yavuz

    2015-01-01

    “Trends and Issues in Instructional Design and Technology” is a reader friendly reference source on instructional design and technology (IDT) helping both professionals in the field and novice practitioners trying to get used to the trends and concepts of the field.

  9. Optimization of formulation variables of benzocaine liposomes using experimental design.

    Science.gov (United States)

    Mura, Paola; Capasso, Gaetano; Maestrelli, Francesca; Furlanetto, Sandra

    2008-01-01

    This study aimed to optimize, by means of an experimental design multivariate strategy, a liposomal formulation for topical delivery of the local anaesthetic agent benzocaine. The formulation variables for the vesicle lipid phase uses potassium glycyrrhizinate (KG) as an alternative to cholesterol and the addition of a cationic (stearylamine) or anionic (dicethylphosphate) surfactant (qualitative factors); the percents of ethanol and the total volume of the hydration phase (quantitative factors) were the variables for the hydrophilic phase. The combined influence of these factors on the considered responses (encapsulation efficiency (EE%) and percent drug permeated at 180 min (P%)) was evaluated by means of a D-optimal design strategy. Graphic analysis of the effects indicated that maximization of the selected responses requested opposite levels of the considered factors: For example, KG and stearylamine were better for increasing EE%, and cholesterol and dicethylphosphate for increasing P%. In the second step, the Doehlert design, applied for the response-surface study of the quantitative factors, pointed out a negative interaction between percent ethanol and volume of the hydration phase and allowed prediction of the best formulation for maximizing drug permeation rate. Experimental P% data of the optimized formulation were inside the confidence interval (P < 0.05) calculated around the predicted value of the response. This proved the suitability of the proposed approach for optimizing the composition of liposomal formulations and predicting the effects of formulation variables on the considered experimental response. Moreover, the optimized formulation enabled a significant improvement (P < 0.05) of the drug anaesthetic effect with respect to the starting reference liposomal formulation, thus demonstrating its actually better therapeutic effectiveness.

  10. Enhancing public involvement in assistive technology design research.

    Science.gov (United States)

    Williamson, Tracey; Kenney, Laurence; Barker, Anthony T; Cooper, Glen; Good, Tim; Healey, Jamie; Heller, Ben; Howard, David; Matthews, Martin; Prenton, Sarah; Ryan, Julia; Smith, Christine

    2015-05-01

    To appraise the application of accepted good practice guidance on public involvement in assistive technology research and to identify its impact on the research team, the public, device and trial design. Critical reflection and within-project evaluation were undertaken in a case study of the development of a functional electrical stimulation device. Individual and group interviews were undertaken with lay members of a 10 strong study user advisory group and also research team members. Public involvement was seen positively by research team members, who reported a positive impact on device and study designs. The public identified positive impact on confidence, skills, self-esteem, enjoyment, contribution to improving the care of others and opportunities for further involvement in research. A negative impact concerned the challenge of engaging the public in dissemination after the study end. The public were able to impact significantly on the design of an assistive technology device which was made more fit for purpose. Research team attitudes to public involvement were more positive after having witnessed its potential first hand. Within-project evaluation underpins this case study which presents a much needed detailed account of public involvement in assistive technology design research to add to the existing weak evidence base. The evidence base for impact of public involvement in rehabilitation technology design is in need of development. Public involvement in co-design of rehabilitation devices can lead to technologies that are fit for purpose. Rehabilitation researchers need to consider the merits of active public involvement in research.

  11. Technology computer aided design simulation for VLSI MOSFET

    CERN Document Server

    Sarkar, Chandan Kumar

    2013-01-01

    Responding to recent developments and a growing VLSI circuit manufacturing market, Technology Computer Aided Design: Simulation for VLSI MOSFET examines advanced MOSFET processes and devices through TCAD numerical simulations. The book provides a balanced summary of TCAD and MOSFET basic concepts, equations, physics, and new technologies related to TCAD and MOSFET. A firm grasp of these concepts allows for the design of better models, thus streamlining the design process, saving time and money. This book places emphasis on the importance of modeling and simulations of VLSI MOS transistors and

  12. Ethics of Living Technology: Design Principles for Proactive Home Environments

    Directory of Open Access Journals (Sweden)

    Frans Mäyrä

    2004-07-01

    Full Text Available The entry of proactive technology into highly sensitive environments, such as the home, produces specific design challenges that are inextricably linked to ethical issues. Two design goals are presented and analysed: proactive solutions have to be both personalized and consistent. These requirements are partially contradictory, and need to be understood in the context of the socio-cognitive setting of the home. The embedding of proactive technology into a home environment has to provide the user with an awareness of the possibilities of control and play. These design goals are further developed with regard to different user cultures: here we concentrate on early adopters and elderly people.

  13. Designing artificial enzymes from scratch: Experimental study and mesoscale simulation

    Science.gov (United States)

    Komarov, Pavel V.; Zaborina, Olga E.; Klimova, Tamara P.; Lozinsky, Vladimir I.; Khalatur, Pavel G.; Khokhlov, Alexey R.

    2016-09-01

    We present a new concept for designing biomimetic analogs of enzymatic proteins; these analogs are based on the synthetic protein-like copolymers. α-Chymotrypsin is used as a prototype of the artificial catalyst. Our experimental study shows that in the course of free radical copolymerization of hydrophobic and hydrophilic monomers the target globular nanostructures of a "core-shell" morphology appear in a selective solvent. Using a mesoscale computer simulation, we show that the protein-like globules can have a large number of catalytic centers located at the hydrophobic core/hydrophilic shell interface.

  14. On the proper study design applicable to experimental balneology

    Science.gov (United States)

    Varga, Csaba

    2016-08-01

    The simple message of this paper is that it is the high time to reevaluate the strategies and optimize the efforts for investigation of thermal (spa) waters. Several articles trying to clear mode of action of medicinal waters have been published up to now. Almost all studies apply the unproven hypothesis, namely the inorganic ingredients are in close connection with healing effects of bathing. Change of paradigm would be highly necessary in this field taking into consideration the presence of several biologically active organic substances in these waters. A successful design for experimental mechanistic studies is approved.

  15. On the proper study design applicable to experimental balneology.

    Science.gov (United States)

    Varga, Csaba

    2016-08-01

    The simple message of this paper is that it is the high time to reevaluate the strategies and optimize the efforts for investigation of thermal (spa) waters. Several articles trying to clear mode of action of medicinal waters have been published up to now. Almost all studies apply the unproven hypothesis, namely the inorganic ingredients are in close connection with healing effects of bathing. Change of paradigm would be highly necessary in this field taking into consideration the presence of several biologically active organic substances in these waters. A successful design for experimental mechanistic studies is approved.

  16. Statistics for proteomics: experimental design and 2-DE differential analysis.

    Science.gov (United States)

    Chich, Jean-François; David, Olivier; Villers, Fanny; Schaeffer, Brigitte; Lutomski, Didier; Huet, Sylvie

    2007-04-15

    Proteomics relies on the separation of complex protein mixtures using bidimensional electrophoresis. This approach is largely used to detect the expression variations of proteins prepared from two or more samples. Recently, attention was drawn on the reliability of the results published in literature. Among the critical points identified were experimental design, differential analysis and the problem of missing data, all problems where statistics can be of help. Using examples and terms understandable by biologists, we describe how a collaboration between biologists and statisticians can improve reliability of results and confidence in conclusions.

  17. Optimal experimental design to position transducers in ultrasound breast imaging

    Science.gov (United States)

    Korta Martiartu, Naiara; Boehm, Christian; Vinard, Nicolas; Jovanović Balic, Ivana; Fichtner, Andreas

    2017-03-01

    We present methods to optimize the setup of a 3D ultrasound tomography scanner for breast cancer detection. This approach provides a systematic and quantitative tool to evaluate different designs and to optimize the con- figuration with respect to predefined design parameters. We consider both, time-of-flight inversion using straight rays and time-domain waveform inversion governed by the acoustic wave equation for imaging the sound speed. In order to compare different designs, we measure their quality by extracting properties from the Hessian operator of the time-of-flight or waveform differences defined in the inverse problem, i.e., the second derivatives with respect to the sound speed. Spatial uncertainties and resolution can be related to the eigenvalues of the Hessian, which provide a good indication of the information contained in the data that is acquired with a given design. However, the complete spectrum is often prohibitively expensive to compute, thus suitable approximations have to be developed and analyzed. We use the trace of the Hessian operator as design criterion, which is equivalent to the sum of all eigenvalues and requires less computational effort. In addition, we suggest to take advantage of the spatial symmetry to extrapolate the 3D experimental design from a set of 2D configurations. In order to maximize the quality criterion, we use a genetic algorithm to explore the space of possible design configurations. Numerical results show that the proposed strategies are capable of improving an initial configuration with uniformly distributed transducers, clustering them around regions with poor illumination and improving the ray coverage of the domain of interest.

  18. Designing interactive technology for crowd experiences - beyond sanitization

    DEFF Research Database (Denmark)

    Veerasawmy, Rune

    2014-01-01

    This dissertation concerns the topic on designing interactive technology for crowd expe- riences. It takes the outset in the experience-oriented design approach within interaction design, exploring the research question how can we conceptually understand and design interactive technology for crowd...... in a conceptual model of social experiences that presents crowd experiences as a distinct type of social experience. This is different from what previously have been explored within experi- ence-oriented design. This dissertation is composed of four research papers framed by an overview that summarizes...... experience within interaction design. This dissertation introduces an understanding of crowd experience as a distinct type of social experiences driven by non-rational behavior. This conceptual understanding is established in the intersection between sociological crowd theory and a pragmatist perspective...

  19. User-centered design and interactive health technologies for patients.

    Science.gov (United States)

    De Vito Dabbs, Annette; Myers, Brad A; Mc Curry, Kenneth R; Dunbar-Jacob, Jacqueline; Hawkins, Robert P; Begey, Alex; Dew, Mary Amanda

    2009-01-01

    Despite recommendations that patients be involved in the design and testing of health technologies, few reports describe how to involve patients in systematic and meaningful ways to ensure that applications are customized to meet their needs. User-centered design is an approach that involves end users throughout the development process so that technologies support tasks, are easy to operate, and are of value to users. In this article, we provide an overview of user-centered design and use the development of Pocket Personal Assistant for Tracking Health (Pocket PATH) to illustrate how these principles and techniques were applied to involve patients in the development of this interactive health technology. Involving patient-users in the design and testing ensured functionality and usability, therefore increasing the likelihood of promoting the intended health outcomes.

  20. Discuss the Development of Computer-Aided Industrial Design Technology

    Directory of Open Access Journals (Sweden)

    Jun Yao

    2013-01-01

    Full Text Available The direction of the development of the industrial design gradually approaches mechanical-electrical integration and informational and electronic products. With an increasing improvement of its technical content, and better social economic conditions, peoples consumption concept are getting more and more different. Consumer concerns not just the functionality and quality of the product, more and more people are starting to focus on the appearance of the product, degree of innovation, environmental protection, and so on, which brings a higher degree of difficulty to the industrial technology. It is because the increasing demands of people and the industrial design, many scholars are increasingly concerned about the industrial design in recent years. With the continuous development of computer technology, a wide variety of hardware and software are developed, and a variety of ever-changing technologies are attracting the industrial design talents as well.

  1. Experimental study on ceramic membrane technology for onboard oxygen generation

    Institute of Scientific and Technical Information of China (English)

    Jiang Dongsheng; Bu Xueqin; Sun Bing; Lin Guiping; Zhao Hongtao; Cai Yan; Fang Ling

    2016-01-01

    The ceramic membrane oxygen generation technology has advantages of high concentra-tion of produced oxygen and potential nuclear and biochemical protection capability. The present paper studies the ceramic membrane technology for onboard oxygen generation. Comparisons are made to have knowledge of the effects of two kinds of ceramic membrane separation technologies on oxygen generation, namely electricity driven ceramic membrane separation oxygen generation technology (EDCMSOGT) and pressure driven ceramic membrane separation oxygen generation technology (PDCMSOGT). Experiments were conducted under different temperatures, pressures of feed air and produced oxygen flow rates. On the basis of these experiments, the flow rate of feed air, electric power provided, oxygen recovery rate and concentration of produced oxygen are compared under each working condition. It is concluded that the EDCMSOGT is the oxygen generation means more suitable for onboard conditions.

  2. Experimental study on ceramic membrane technology for onboard oxygen generation

    Directory of Open Access Journals (Sweden)

    Jiang Dongsheng

    2016-08-01

    Full Text Available The ceramic membrane oxygen generation technology has advantages of high concentration of produced oxygen and potential nuclear and biochemical protection capability. The present paper studies the ceramic membrane technology for onboard oxygen generation. Comparisons are made to have knowledge of the effects of two kinds of ceramic membrane separation technologies on oxygen generation, namely electricity driven ceramic membrane separation oxygen generation technology (EDCMSOGT and pressure driven ceramic membrane separation oxygen generation technology (PDCMSOGT. Experiments were conducted under different temperatures, pressures of feed air and produced oxygen flow rates. On the basis of these experiments, the flow rate of feed air, electric power provided, oxygen recovery rate and concentration of produced oxygen are compared under each working condition. It is concluded that the EDCMSOGT is the oxygen generation means more suitable for onboard conditions.

  3. Comparing Simulated Emission from Molecular Clouds Using Experimental Design

    CERN Document Server

    Yeremi, Miayan; Offner, Stella; Loeppky, Jason; Rosolowsky, Erik

    2014-01-01

    We propose a new approach to comparing simulated observations that enables us to determine the significance of the underlying physical effects. We utilize the methodology of experimental design, a subfield of statistical analysis, to establish a framework for comparing simulated position-position-velocity data cubes to each other. We propose three similarity metrics based on methods described in the literature: principal component analysis, the spectral correlation function, and the Cramer multi-variate two sample similarity statistic. Using these metrics, we intercompare a suite of mock observational data of molecular clouds generated from magnetohydrodynamic simulations with varying physical conditions. Using this framework, we show that all three metrics are sensitive to changing Mach number and temperature in the simulation sets, but cannot detect changes in magnetic field strength and initial velocity spectrum. We highlight the shortcomings of one-factor-at-a-time designs commonly used in astrophysics an...

  4. Parameters optimization for enzymatic assays using experimental design

    Directory of Open Access Journals (Sweden)

    J. F. M. Burkert

    2006-06-01

    Full Text Available The conditions for maximization enzymatic activity were determined using experimental design and inulinase from Kluyveromyces marxianus ATCC 16045. The effects of substrate concentration (sucrose and inulin, pH and temperature on inulinase activity were verified using four factorial design and surface response analysis. Using sucrose as substrate. It has bean shown that the effects sucrose on enzymatic activity is not statistically significant and the best condition for the highest activity (110 U/mL was achieved with temperature between 60°C and 68°C and pH between 4.5 and 5.0. Using inulin as substrate it was verified that temperature is the only variable statistically significant and the maximum activity was 7.3 U/mL at temperature between 50°C and 51°C.

  5. Bayesian experimental design for models with intractable likelihoods.

    Science.gov (United States)

    Drovandi, Christopher C; Pettitt, Anthony N

    2013-12-01

    In this paper we present a methodology for designing experiments for efficiently estimating the parameters of models with computationally intractable likelihoods. The approach combines a commonly used methodology for robust experimental design, based on Markov chain Monte Carlo sampling, with approximate Bayesian computation (ABC) to ensure that no likelihood evaluations are required. The utility function considered for precise parameter estimation is based upon the precision of the ABC posterior distribution, which we form efficiently via the ABC rejection algorithm based on pre-computed model simulations. Our focus is on stochastic models and, in particular, we investigate the methodology for Markov process models of epidemics and macroparasite population evolution. The macroparasite example involves a multivariate process and we assess the loss of information from not observing all variables.

  6. Design and Testing of CO2 Compression Using Supersonic Shockware Technology

    Energy Technology Data Exchange (ETDEWEB)

    Joe Williams; Michael Aarnio; Kirk Lupkes; Sabri Deniz

    2010-08-31

    Documentation of work performed by Ramgen and subcontractors in pursuit of design and construction of a 10 MW supersonic CO{sub 2} compressor and supporting facility. The compressor will demonstrate application of Ramgen's supersonic compression technology at an industrial scale using CO{sub 2} in a closed-loop. The report includes details of early feasibility studies, CFD validation and comparison to experimental data, static test experimental results, compressor and facility design and analyses, and development of aero tools.

  7. Experimental design and multicriteria decision making methods for the optimization of ice cream composition

    Directory of Open Access Journals (Sweden)

    Cristian Rojas

    2012-03-01

    Full Text Available The aim of the present work was to optimize the sensorial and technological features of ice cream. The experimental work was performed in two stages: 1 optimization of lactose enzymatic hydrolysis, and 2 optimization of the process and product. For the first stage a complete factorial design was developed, optimized using both response surface and the steepest ascent method. In the second stage a mixture design was performed, combining the process variables. The product with the best sensorial acceptance, high yield and low cost was selected. The acceptance of the product was developed by an untrained taster’s panel. As a main result the sensorial and technological features of the final product were improved, establishing the optimum parameters for its elaboration.

  8. Design of Experimental Suspended Footbridge with Deck Made of UHPC

    Directory of Open Access Journals (Sweden)

    Blank Marek

    2016-01-01

    Full Text Available This paper deals with the static and dynamic design of experimental footbridge for pedestrians and cyclists in the municipality Lužec nad Vltavou in Czech Republic, Europe. This work aims to familiarize the reader with calculations carried out and the results obtained, describing the static and dynamic properties of proposed footbridge. The construction of footbridge is designed as a suspended structure with prestressed bridge deck consisting of prefabricated UHPC panels and reversed “V” shaped steel pylon with height of approximately 40 meters. The deck is anchored using 24 steel hangers in one row in a steel pylon - 17 ropes in the main span and 7 cables on the other side. Range of the main span is 99.18 meters and the secondary span is 31.9 m. Deck width is 4.5 meters with 3.0 meters passing space. The bridge is designed for the possibility of passage of vehicles weighting up to 3.5 tons. Deck panels are made of UHPC with reinforcement. At the edge of the bridge on the side of the shorter span the bridge deck is firmly connected with abutment and on the other deck it is stored using a pair of sliding bearings. The utilization of the excellent properties of UHPC allows to design a very thin and lightweight construction of the deck, which could not be achieved with the use of normal concrete.

  9. Logical Experimental Design and Execution in the Biomedical Sciences.

    Science.gov (United States)

    Holder, Daniel J; Marino, Michael J

    2017-03-17

    Lack of reproducibility has been highlighted as a significant problem in biomedical research. The present unit is devoted to describing ways to help ensure that research findings can be replicated by others, with a focus on the design and execution of laboratory experiments. Essential components for this include clearly defining the question being asked, using available information or information from pilot studies to aid in the design the experiment, and choosing manipulations under a logical framework based on Mill's "methods of knowing" to build confidence in putative causal links. Final experimental design requires systematic attention to detail, including the choice of controls, sample selection, blinding to avoid bias, and the use of power analysis to determine the sample size. Execution of the experiment is done with care to ensure that the independent variables are controlled and the measurements of the dependent variables are accurate. While there are always differences among laboratories with respect to technical expertise, equipment, and suppliers, execution of the steps itemized in this unit will ensure well-designed and well-executed experiments to answer any question in biomedical research. © 2017 by John Wiley & Sons, Inc. Copyright © 2017 John Wiley & Sons, Inc.

  10. Binarial hermeneutics for exploring the phenomenon of Technology in support of Design and Technology Education

    OpenAIRE

    2013-01-01

    The phenomenon of technology remains a challenge for philosophers of technology itself let alone for the field of Design and Technology education. Because ‘technology’ is a complex concept it defies definition and finds itself the object of study of multiple disciplines such as philosophy, sociology, psychology, anthropology, history, and more. This paper introduces the concept of ‘binarial hermeneutics’ as a means for exploring, in a non- or anti-disciplinary way, the phenomenon of tech...

  11. WEARABLE TECHNOLOGY: FASHION DESIGNERS BRINGS TOGETHER FASHION WITH SCIENCE

    Directory of Open Access Journals (Sweden)

    Gozde Yetmen

    2017-04-01

    Full Text Available In this paper, from the designers, engineers, scientists and technicians are working multidisciplinary and developed in process of time; electronic textiles, smart textiles, nano technology, 3D printed textiles and coded couture. As a result today generated "Wearable Technology". Designer creates contemporary fashion design products and concepts will be examined in this paper. Since the mid-twentieth century, to today’s XXI Century, living an important technological development for the future of fashion is to ensure the creation of high tech fabrics with functional textile fibers. 21st Century avant-garde fashion designers: Hussein Chalayan, Ryan Genz & Francesca Rosella and Anouk Wipprecht are working on the future garment design and determine a new visions that the texture of the emerging trends and technologies in the area of fashion. They realized that the importance of innovation in their collections. For this reason, textile engineers and scientists are working together and investigating various technologies to develop a variety of innovative fabrics or garments.

  12. Fast Bayesian optimal experimental design for seismic source inversion

    KAUST Repository

    Long, Quan

    2015-07-01

    We develop a fast method for optimally designing experiments in the context of statistical seismic source inversion. In particular, we efficiently compute the optimal number and locations of the receivers or seismographs. The seismic source is modeled by a point moment tensor multiplied by a time-dependent function. The parameters include the source location, moment tensor components, and start time and frequency in the time function. The forward problem is modeled by elastodynamic wave equations. We show that the Hessian of the cost functional, which is usually defined as the square of the weighted L2 norm of the difference between the experimental data and the simulated data, is proportional to the measurement time and the number of receivers. Consequently, the posterior distribution of the parameters, in a Bayesian setting, concentrates around the "true" parameters, and we can employ Laplace approximation and speed up the estimation of the expected Kullback-Leibler divergence (expected information gain), the optimality criterion in the experimental design procedure. Since the source parameters span several magnitudes, we use a scaling matrix for efficient control of the condition number of the original Hessian matrix. We use a second-order accurate finite difference method to compute the Hessian matrix and either sparse quadrature or Monte Carlo sampling to carry out numerical integration. We demonstrate the efficiency, accuracy, and applicability of our method on a two-dimensional seismic source inversion problem. © 2015 Elsevier B.V.

  13. Prediction uncertainty and optimal experimental design for learning dynamical systems

    Science.gov (United States)

    Letham, Benjamin; Letham, Portia A.; Rudin, Cynthia; Browne, Edward P.

    2016-06-01

    Dynamical systems are frequently used to model biological systems. When these models are fit to data, it is necessary to ascertain the uncertainty in the model fit. Here, we present prediction deviation, a metric of uncertainty that determines the extent to which observed data have constrained the model's predictions. This is accomplished by solving an optimization problem that searches for a pair of models that each provides a good fit for the observed data, yet has maximally different predictions. We develop a method for estimating a priori the impact that additional experiments would have on the prediction deviation, allowing the experimenter to design a set of experiments that would most reduce uncertainty. We use prediction deviation to assess uncertainty in a model of interferon-alpha inhibition of viral infection, and to select a sequence of experiments that reduces this uncertainty. Finally, we prove a theoretical result which shows that prediction deviation provides bounds on the trajectories of the underlying true model. These results show that prediction deviation is a meaningful metric of uncertainty that can be used for optimal experimental design.

  14. Fast Bayesian Optimal Experimental Design for Seismic Source Inversion

    KAUST Repository

    Long, Quan

    2016-01-06

    We develop a fast method for optimally designing experiments [1] in the context of statistical seismic source inversion [2]. In particular, we efficiently compute the optimal number and locations of the receivers or seismographs. The seismic source is modeled by a point moment tensor multiplied by a time-dependent function. The parameters include the source location, moment tensor components, and start time and frequency in the time function. The forward problem is modeled by the elastic wave equations. We show that the Hessian of the cost functional, which is usually defined as the square of the weighted L2 norm of the difference between the experimental data and the simulated data, is proportional to the measurement time and the number of receivers. Consequently, the posterior distribution of the parameters, in a Bayesian setting, concentrates around the true parameters, and we can employ Laplace approximation and speed up the estimation of the expected Kullback-Leibler divergence (expected information gain), the optimality criterion in the experimental design procedure. Since the source parameters span several magnitudes, we use a scaling matrix for efficient control of the condition number of the original Hessian matrix. We use a second-order accurate finite difference method to compute the Hessian matrix and either sparse quadrature or Monte Carlo sampling to carry out numerical integration. We demonstrate the efficiency, accuracy, and applicability of our method on a two-dimensional seismic source inversion problem.

  15. Experimental study of elementary collection efficiency of aerosols by spray: Design of the experimental device

    Energy Technology Data Exchange (ETDEWEB)

    Ducret, D.; Vendel, J.; Garrec. S.L.

    1995-02-01

    The safety of a nuclear power plant containment building, in which pressure and temperature could increase because of a overheating reactor accident, can be achieved by spraying water drops. The spray reduces the pressure and the temperature levels by condensation of steam on cold water drops. The more stringent thermodynamic conditions are a pressure of 5.10{sup 5} Pa (due to steam emission) and a temperature of 413 K. Moreover its energy dissipation function, the spray leads to the washout of fission product particles emitted in the reactor building atmosphere. The present study includes a large program devoted to the evaluation of realistic washout rates. The aim of this work is to develop experiments in order to determine the collection efficiency of aerosols by a single drop. To do this, the experimental device has to be designed with fundamental criteria:-Thermodynamic conditions have to be representative of post-accident atmosphere. Thermodynamic equilibrium has to be attained between the water drops and the gaseous phase. Thermophoretic, diffusiophoretic and mechanical effects have to be studied independently. Operating conditions have to be homogenous and constant during each experiment. This paper presents the design of the experimental device. In practice, the consequences on the design of each of the criteria given previously and the necessity of being representative of the real conditions will be described.

  16. Technological Discontinuities and Dominant Designs: A Cyclical Model of Technological Change.

    Science.gov (United States)

    Anderson, Philip; Tushman, Michael L.

    1990-01-01

    Based on longitudinal studies of the cement, glass, and minicomputer industries, this article proposes a technological change model in which a technological breakthrough, or discontinuity, initiates an era of intense technical variation and selection, culminating in a single dominant design and followed by a period of incremental technical…

  17. Mobile Technology and CAD Technology Integration in Teaching Architectural Design Process for Producing Creative Product

    Science.gov (United States)

    Bin Hassan, Isham Shah; Ismail, Mohd Arif; Mustafa, Ramlee

    2011-01-01

    The purpose of this research is to examine the effect of integrating the mobile and CAD technology on teaching architectural design process for Malaysian polytechnic architectural students in producing a creative product. The website is set up based on Caroll's minimal theory, while mobile and CAD technology integration is based on Brown and…

  18. Experimental design and quality assurance: in situ fluorescence instrumentation

    Science.gov (United States)

    Conmy, Robyn N.; Del Castillo, Carlos E.; Downing, Bryan D.; Chen, Robert F.

    2014-01-01

    Both instrument design and capabilities of fluorescence spectroscopy have greatly advanced over the last several decades. Advancements include solid-state excitation sources, integration of fiber optic technology, highly sensitive multichannel detectors, rapid-scan monochromators, sensitive spectral correction techniques, and improve data manipulation software (Christian et al., 1981, Lochmuller and Saavedra, 1986; Cabniss and Shuman, 1987; Lakowicz, 2006; Hudson et al., 2007). The cumulative effect of these improvements have pushed the limits and expanded the application of fluorescence techniques to numerous scientific research fields. One of the more powerful advancements is the ability to obtain in situ fluorescence measurements of natural waters (Moore, 1994). The development of submersible fluorescence instruments has been made possible by component miniaturization and power reduction including advances in light sources technologies (light-emitting diodes, xenon lamps, ultraviolet [UV] lasers) and the compatible integration of new optical instruments with various sampling platforms (Twardowski et at., 2005 and references therein). The development of robust field sensors skirt the need for cumbersome and or time-consuming filtration techniques, the potential artifacts associated with sample storage, and coarse sampling designs by increasing spatiotemporal resolution (Chen, 1999; Robinson and Glenn, 1999). The ability to obtain rapid, high-quality, highly sensitive measurements over steep gradients has revolutionized investigations of dissolved organic matter (DOM) optical properties, thereby enabling researchers to address novel biogeochemical questions regarding colored or chromophoric DOM (CDOM). This chapter is dedicated to the origin, design, calibration, and use of in situ field fluorometers. It will serve as a review of considerations to be accounted for during the operation of fluorescence field sensors and call attention to areas of concern when making

  19. Experimental Design for the INL Sample Collection Operational Test

    Energy Technology Data Exchange (ETDEWEB)

    Amidan, Brett G.; Piepel, Gregory F.; Matzke, Brett D.; Filliben, James J.; Jones, Barbara

    2007-12-13

    This document describes the test events and numbers of samples comprising the experimental design that was developed for the contamination, decontamination, and sampling of a building at the Idaho National Laboratory (INL). This study is referred to as the INL Sample Collection Operational Test. Specific objectives were developed to guide the construction of the experimental design. The main objective is to assess the relative abilities of judgmental and probabilistic sampling strategies to detect contamination in individual rooms or on a whole floor of the INL building. A second objective is to assess the use of probabilistic and Bayesian (judgmental + probabilistic) sampling strategies to make clearance statements of the form “X% confidence that at least Y% of a room (or floor of the building) is not contaminated. The experimental design described in this report includes five test events. The test events (i) vary the floor of the building on which the contaminant will be released, (ii) provide for varying or adjusting the concentration of contaminant released to obtain the ideal concentration gradient across a floor of the building, and (iii) investigate overt as well as covert release of contaminants. The ideal contaminant gradient would have high concentrations of contaminant in rooms near the release point, with concentrations decreasing to zero in rooms at the opposite end of the building floor. For each of the five test events, the specified floor of the INL building will be contaminated with BG, a stand-in for Bacillus anthracis. The BG contaminant will be disseminated from a point-release device located in the room specified in the experimental design for each test event. Then judgmental and probabilistic samples will be collected according to the pre-specified sampling plan. Judgmental samples will be selected based on professional judgment and prior information. Probabilistic samples will be selected in sufficient numbers to provide desired confidence

  20. Bayesian optimal experimental design for priors of compact support

    KAUST Repository

    Long, Quan

    2016-01-08

    In this study, we optimize the experimental setup computationally by optimal experimental design (OED) in a Bayesian framework. We approximate the posterior probability density functions (pdf) using truncated Gaussian distributions in order to account for the bounded domain of the uniform prior pdf of the parameters. The underlying Gaussian distribution is obtained in the spirit of the Laplace method, more precisely, the mode is chosen as the maximum a posteriori (MAP) estimate, and the covariance is chosen as the negative inverse of the Hessian of the misfit function at the MAP estimate. The model related entities are obtained from a polynomial surrogate. The optimality, quantified by the information gain measures, can be estimated efficiently by a rejection sampling algorithm against the underlying Gaussian probability distribution, rather than against the true posterior. This approach offers a significant error reduction when the magnitude of the invariants of the posterior covariance are comparable to the size of the bounded domain of the prior. We demonstrate the accuracy and superior computational efficiency of our method for shock-tube experiments aiming to measure the model parameters of a key reaction which is part of the complex kinetic network describing the hydrocarbon oxidation. In the experiments, the initial temperature and fuel concentration are optimized with respect to the expected information gain in the estimation of the parameters of the target reaction rate. We show that the expected information gain surface can change its shape dramatically according to the level of noise introduced into the synthetic data. The information that can be extracted from the data saturates as a logarithmic function of the number of experiments, and few experiments are needed when they are conducted at the optimal experimental design conditions.

  1. Experimental design in phylogenetics: testing predictions from expected information.

    Science.gov (United States)

    San Mauro, Diego; Gower, David J; Cotton, James A; Zardoya, Rafael; Wilkinson, Mark; Massingham, Tim

    2012-07-01

    Taxon and character sampling are central to phylogenetic experimental design; yet, we lack general rules. Goldman introduced a method to construct efficient sampling designs in phylogenetics, based on the calculation of expected Fisher information given a probabilistic model of sequence evolution. The considerable potential of this approach remains largely unexplored. In an earlier study, we applied Goldman's method to a problem in the phylogenetics of caecilian amphibians and made an a priori evaluation and testable predictions of which taxon additions would increase information about a particular weakly supported branch of the caecilian phylogeny by the greatest amount. We have now gathered mitogenomic and rag1 sequences (some newly determined for this study) from additional caecilian species and studied how information (both expected and observed) and bootstrap support vary as each new taxon is individually added to our previous data set. This provides the first empirical test of specific predictions made using Goldman's method for phylogenetic experimental design. Our results empirically validate the top 3 (more intuitive) taxon addition predictions made in our previous study, but only information results validate unambiguously the 4th (less intuitive) prediction. This highlights a complex relationship between information and support, reflecting that each measures different things: Information is related to the ability to estimate branch length accurately and support to the ability to estimate the tree topology accurately. Thus, an increase in information may be correlated with but does not necessitate an increase in support. Our results also provide the first empirical validation of the widely held intuition that additional taxa that join the tree proximal to poorly supported internal branches are more informative and enhance support more than additional taxa that join the tree more distally. Our work supports the view that adding more data for a single (well

  2. Aspects of experimental design for plant metabolomics experiments and guidelines for growth of plant material.

    Science.gov (United States)

    Gibon, Yves; Rolin, Dominique

    2012-01-01

    Experiments involve the deliberate variation of one or more factors in order to provoke responses, the identification of which then provides the first step towards functional knowledge. Because environmental, biological, and/or technical noise is unavoidable, biological experiments usually need to be designed. Thus, once the major sources of experimental noise have been identified, individual samples can be grouped, randomised, and/or pooled. Like other 'omics approaches, metabolomics is characterised by the numbers of analytes largely exceeding sample number. While this unprecedented singularity in biology dramatically increases false discovery, experimental error can nevertheless be decreased in plant metabolomics experiments. For this, each step from plant cultivation to data acquisition needs to be evaluated in order to identify the major sources of error and then an appropriate design can be produced, as with any other experimental approach. The choice of technology, the time at which tissues are harvested, and the way metabolism is quenched also need to be taken into consideration, as they decide which metabolites can be studied. A further recommendation is to document data and metadata in a machine readable way. The latter should also describe every aspect of the experiment. This should provide valuable hints for future experimental design and ultimately give metabolomic data a second life. To facilitate the identification of critical steps, a list of items to be considered before embarking on time-consuming and costly metabolomic experiments is proposed.

  3. Design, experimentation, and modeling of a novel continuous biodrying process

    Science.gov (United States)

    Navaee-Ardeh, Shahram

    Massive production of sludge in the pulp and paper industry has made the effective sludge management increasingly a critical issue for the industry due to high landfill and transportation costs, and complex regulatory frameworks for options such as sludge landspreading and composting. Sludge dewatering challenges are exacerbated at many mills due to improved in-plant fiber recovery coupled with increased production of secondary sludge, leading to a mixed sludge with a high proportion of biological matter which is difficult to dewater. In this thesis, a novel continuous biodrying reactor was designed and developed for drying pulp and paper mixed sludge to economic dry solids level so that the dried sludge can be economically and safely combusted in a biomass boiler for energy recovery. In all experimental runs the economic dry solids level was achieved, proving the process successful. In the biodrying process, in addition to the forced aeration, the drying rates are enhanced by biological heat generated through the microbial activity of mesophilic and thermophilic microorganisms naturally present in the porous matrix of mixed sludge. This makes the biodrying process more attractive compared to the conventional drying techniques because the reactor is a self-heating process. The reactor is divided into four nominal compartments and the mixed sludge dries as it moves downward in the reactor. The residence times were 4-8 days, which are 2-3 times shorter than the residence times achieved in a batch biodrying reactor previously studied by our research group for mixed sludge drying. A process variable analysis was performed to determine the key variable(s) in the continuous biodrying reactor. Several variables were investigated, namely: type of biomass feed, pH of biomass, nutrition level (C/N ratio), residence times, recycle ratio of biodried sludge, and outlet relative humidity profile along the reactor height. The key variables that were identified in the continuous

  4. Nature of Technology: Implications for design, development, and enactment of technological tools in school science classrooms

    Science.gov (United States)

    Waight, Noemi; Abd-El-Khalick, Fouad

    2012-12-01

    This position paper provides a theory-based explanation informed by philosophy of technology (PoT) of the recurrent documented patterns often associated with attempts to enact technology-supported, inquiry-based approaches in precollege science classrooms. Understandings derived from the history of technological development in other domains (e.g. medicine, transportation, and warfare) reveal numerous parallels that help to explain these recurrent patterns. Historical analyses of major technologies reveal a conglomerate of factors that interact to produce benefits, as well as intended and unintended consequences. On a macro-scale, PoT facilitates understandings of how technologies interact and are impacted by individuals, society, institutions, economy, politics, and culture. At the micro-level, and most relevant to science education, PoT engages the inherent nature of technology along a number of key dimensions: role of culture and values, notions of technological progression, technology as part of systems, technological diffusion, technology as a fix, and the notions of expertise. Overall, the present analysis has implications for the design, development, implementation, and adoption of technological tools for use in precollege science education, and highlights the role of technology as both artifact and process.

  5. Terrestrial Planet Finder Interferometer: Architecture, Mission Design, and Technology Development

    Science.gov (United States)

    Henry, Curt

    2004-01-01

    This slide presentation represents an overview progress report about the system design and technology development of two interferometer concepts studied for the Terrestrial Planet Finder (TPF) project. The two concepts are a structurally-connected interferometer (SCI) intended to fulfill minimum TPF science goals and a formation-flying interferometer (FFI) intended to fulfill full science goals. Described are major trades, analyses, and technology experiments completed. Near term plans are also described. This paper covers progress since August 2003

  6. A Designated Harmonic Suppression Technology for Sampled SPWM

    Institute of Scientific and Technical Information of China (English)

    YANG Ping

    2005-01-01

    Sampled SPWM is an excellent VVVF method of motor speed control, meanwhile the harmonic components of the output wave impairs its applications in practice. A designated harmonic suppression technology is presented for sampled SPWM, which is an improved algorithm for the harmonic suppression in high voltage and high frequency spectrum. As the technology is applied in whole speed adjusting range, the voltage can be conveniently controlled and high frequency harmonic of SP WM is also improved.

  7. Ultra-Low Power Memory Design in Scaled Technology Nodes

    DEFF Research Database (Denmark)

    Zeinali, Behzad

    2017-01-01

    technology nodes, this thesis also investigates emerging non-volatile spintronics memories. In this respect, STT-MRAMs and SOT-MRAMs are studied and their design challenges are explored. To improve the read performance of STT-MRAMs, a novel non-destructive self-reference sensing scheme is proposed enabling......In today’s chip design, robust memory design is one of the key challenges of process technology scaling. The steady pace of process technology scaling allows doubling memory array sizes approximately every 2 years. However, further scaling emerges undesirable effects which threaten the power......-efficiency, robust performance and high-density of memories. This thesis addresses these challenges and propose different solutions at the device, circuit and architecture levels in traditional SRAMs and emerging spintronics memories. Based on the fact that SRAMs are the dominant structure in cache memories, which...

  8. The Development of Experimental Setups And Experimental Studies of The Process of Energy-Technological Processing of Wood

    Science.gov (United States)

    Timerbaev, Nail F.; Safin, Rushan G.; Ziatdinova, Dilyara F.; Fomin, Anatoly A.; Mokhovikov, Alexey A.

    2016-08-01

    The paper describes the experimental setups for the study of the various stages of the process of energy-technological processing of wood waste with the production of synthesis gas. The systems for the study of conjugated processes of drying, pyrolysis and gasification, that are an integral part of energy-technological processing of wood wastes were developed. Experimental studies of the processes have identified their basic properties and optimum operating parameters, allowing to obtain a synthesis gas suitable for the chemical synthesis of various olefins.

  9. Toward a Theory for the Design of Human Technologies

    DEFF Research Database (Denmark)

    Simonsen, Jesper; Hertzum, Morten; Nielsen, Jørgen Lerche;

    2014-01-01

    Design is increasingly becoming a part of the university curriculum and research agenda. A theory about the pro-cess and practice of design might be important to estab-lish design as a main subject at universities. We believe it is in the interest of many design communities – not least the Partic......Design is increasingly becoming a part of the university curriculum and research agenda. A theory about the pro-cess and practice of design might be important to estab-lish design as a main subject at universities. We believe it is in the interest of many design communities – not least...... the Participatory Design (PD) community – to engage in theorizing design, on the basis of our understanding of design and design practices. This theory could be posi-tioned as an alternative to other attempts to theorize design, for example the influential efforts of the Information Systems (IS) community. We urge...... the PD community to engage in collective theory building, and we present a framework intended to support our shared reflections on the design of human technologies....

  10. Experimental design schemes for learning Boolean network models

    Science.gov (United States)

    Atias, Nir; Gershenzon, Michal; Labazin, Katia; Sharan, Roded

    2014-01-01

    Motivation: A holy grail of biological research is a working model of the cell. Current modeling frameworks, especially in the protein–protein interaction domain, are mostly topological in nature, calling for stronger and more expressive network models. One promising alternative is logic-based or Boolean network modeling, which was successfully applied to model signaling regulatory circuits in human. Learning such models requires observing the system under a sufficient number of different conditions. To date, the amount of measured data is the main bottleneck in learning informative Boolean models, underscoring the need for efficient experimental design strategies. Results: We developed novel design approaches that greedily select an experiment to be performed so as to maximize the difference or the entropy in the results it induces with respect to current best-fit models. Unique to our maximum difference approach is the ability to account for all (possibly exponential number of) Boolean models displaying high fit to the available data. We applied both approaches to simulated and real data from the EFGR and IL1 signaling systems in human. We demonstrate the utility of the developed strategies in substantially improving on a random selection approach. Our design schemes highlight the redundancy in these datasets, leading up to 11-fold savings in the number of experiments to be performed. Availability and implementation: Source code will be made available upon acceptance of the manuscript. Contact: roded@post.tau.ac.il PMID:25161232

  11. Comparing simulated emission from molecular clouds using experimental design

    Energy Technology Data Exchange (ETDEWEB)

    Yeremi, Miayan; Flynn, Mallory; Loeppky, Jason; Rosolowsky, Erik [University of British Columbia, Okanagan Campus, Departments of Physics and Statistics, 3333 University Way, Kelowna BC V1V 1V7 (Canada); Offner, Stella [Yale University Astronomy Department, 260 Whitney Avenue, New Haven, CT 06511 (United States)

    2014-03-10

    We propose a new approach to comparing simulated observations that enables us to determine the significance of the underlying physical effects. We utilize the methodology of experimental design, a subfield of statistical analysis, to establish a framework for comparing simulated position-position-velocity data cubes to each other. We propose three similarity metrics based on methods described in the literature: principal component analysis, the spectral correlation function, and the Cramer multi-variate two-sample similarity statistic. Using these metrics, we intercompare a suite of mock observational data of molecular clouds generated from magnetohydrodynamic simulations with varying physical conditions. Using this framework, we show that all three metrics are sensitive to changing Mach number and temperature in the simulation sets, but cannot detect changes in magnetic field strength and initial velocity spectrum. We highlight the shortcomings of one-factor-at-a-time designs commonly used in astrophysics and propose fractional factorial designs as a means to rigorously examine the effects of changing physical properties while minimizing the investment of computational resources.

  12. Designing a total data solution technology, implementation, and deployment

    CERN Document Server

    Burkey, Roxanne

    2000-01-01

    Your company's global competitiveness depends on the utilization and maintenance of information. Current data handling practices-storing, updating, and accessing data-can be either a problem or a significant strategic advantage for your company. Designing a Total Data Storage Solution: Technology, Implementation, and Deployment gives you the information you need to compare current technologies and determine which is best suited to your enterprise.This book defines and explains the components that make up total cost of ownership along with the impact of integrating current changes in technology

  13. Designing Technology to Address Parent Uncertainty in Childhood Cancer.

    Science.gov (United States)

    Morrison, Caroline F; Szulczewski, Lauren; Strahlendorf, Laura F; Lane, J Blake; Mullins, Larry L; Pai, Ahna L H

    2016-01-01

    The stress and uncertainty created by a child's cancer diagnosis and treatment can affect parent and child functioning. Health technology provides a potential avenue for intervention delivery. Interviews were conducted with parents of children diagnosed with cancer to discover their needs following diagnosis and design a relevant mobile application. Treatment experience was the overarching theme. Subthemes included the emotional response, use of information, and environmental factors. Technology was used primarily to seek out information and communicate with others. Health technologies are gaining popularity and have the potential to be beneficial for patients and families throughout the treatment experience.

  14. The application of artificial intelligence technology to aeronautical system design

    Science.gov (United States)

    Bouchard, E. E.; Kidwell, G. H.; Rogan, J. E.

    1988-01-01

    This paper describes the automation of one class of aeronautical design activity using artificial intelligence and advanced software techniques. Its purpose is to suggest concepts, terminology, and approaches that may be useful in enhancing design automation. By understanding the basic concepts and tasks in design, and the technologies that are available, it will be possible to produce, in the future, systems whose capabilities far exceed those of today's methods. Some of the tasks that will be discussed have already been automated and are in production use, resulting in significant productivity benefits. The concepts and techniques discussed are applicable to all design activity, though aeronautical applications are specifically presented.

  15. All-Digital ADC Design in 65 nm CMOS Technology

    OpenAIRE

    Pathapati, Srinivasa Rao

    2014-01-01

    The design of analog and complex mixed-signal circuits in a deep submicron CMOS process technology is a big challenge. This makes it desirable to shift data converter design towards the digital domain. The advantage of using a fully digital ADC design rather than a traditional analog ADC design is that the circuit is defined by an HDL description and automatically synthesized by tools. It offers low power consumption, low silicon area and a fully optimized gate-level circuit that reduces the ...

  16. Advanced technology's impact on compressor design and development - A perspective

    Science.gov (United States)

    Ball, Calvin L.

    1989-01-01

    A historical perspective of the impact of advanced technologies on compression system design and development for aircraft gas turbine applications is presented. A bright view of the future is projected in which further advancements in compression system technologies will be made. These advancements will have a significant impact on the ability to meet the ever-more-demanding requirements being imposed on the propulsion system for advanced aircraft. Examples are presented of advanced compression system concepts now being studied. The status and potential impact of transitioning from an empirically derived design system to a computationally oriented system are highlighted. A current NASA Lewis Research Center program to enhance this transitioning is described.

  17. Advanced technologies impact on compressor design and development: A perspective

    Science.gov (United States)

    Ball, Calvin L.

    1989-01-01

    A historical perspective of the impact of advanced technologies on compression system design and development for aircraft gas turbine applications is presented. A bright view of the future is projected in which further advancements in compression system technologies will be made. These advancements will have a significant impact on the ability to meet the ever-more-demanding requirements being imposed on the propulsion system for advanced aircraft. Examples are presented of advanced compression system concepts now being studied. The status and potential impact of transitioning from an empirically derived design system to a computationally oriented system are highlighted. A current NASA Lewis Research Center program to enhance this transitioning is described.

  18. Design,fabrication and experimental research for an electrohydrodynamic micropump

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    This paper presented a novel electrohydrodynamic (EHD) micropump based on MEMS technology. The working mechanisms and classification of EHD micropump were introduced. The fabrication process of EHD micropump was presented with the material selection,optimal design of microelectrode and assembly process. Static pressure experiments and flow experiments were carried out using different fluid and the channel depth. The results indicated that the micropump could achieve a maximum static pressure head of 268 Pa at an applied voltage of 90 V. The maximum flow rate of the micropump-driven fluid could reach 106 μL/min. This paper analyzed the future of combining micropump with heat pipe to deal with heat dissipation of high power electronic chips. The maximum heat dissipation capacity of 87 W/cm2 can be realized by vaporizing the micropump-driven liquid on vaporizing section of the heat pipe.

  19. Establishing a "Centre for Engineering Experimentation and Design Simulation": A Step towards Restructuring Engineering Education in India

    Science.gov (United States)

    Venkateswarlu, P.

    2017-01-01

    Reforms in undergraduate engineering curriculum to produce engineers with entrepreneurial skills should address real-world problems relevant to industry and society with active industry support. Technology-assisted, hands-on projects involving experimentation, design simulation and prototyping will transform graduates into professionals with…

  20. Development of mechanical design technology for integral reactor

    Energy Technology Data Exchange (ETDEWEB)

    Park, Keun Bae; Choi, Suhn; Kim, Kang Soo; Kim, Tae Wan; Jeong, Kyeong Hoon; Lee, Gyu Mahn

    1999-03-01

    While Korean nuclear reactor strategy seems to remain focused on the large capacity power generation, it is expected that demand of small and medium size reactor will arise for multi-purpose application such as small capacity power generation, co-generation and sea water desalination. With this in mind, an integral reactor SMART is under development. Design concepts, system layout and types of equipment of integral reactor are significantly different from those of loop type reactor. Conceptual design development of mechanical structures of integral reactor SMART is completed through the first stage of the project. Efforts were endeavored for the establishment of design basis and evaluation of applicable codes and standards. Design and functional requirements of major structural components were setup, and three dimensional structural modelling of SMART reactor vessel assembly was prepared. Also, maintenance and repair scheme as well as preliminary fabricability evaluation were carried out. Since small integral reactor technology includes sensitive technologies and know-how's, it is hard to achieve systematic and comprehensive technology transfer from nuclear-advanced countries. Thus, it is necessary to develop the related design technology and to verify the adopted methodologies through test and experiments in order to assure the structural integrity of reactor system. (author)

  1. Bayesian Optimal Experimental Design Using Multilevel Monte Carlo

    KAUST Repository

    Ben Issaid, Chaouki

    2015-05-12

    Experimental design can be vital when experiments are resource-exhaustive and time-consuming. In this work, we carry out experimental design in the Bayesian framework. To measure the amount of information that can be extracted from the data in an experiment, we use the expected information gain as the utility function, which specifically is the expected logarithmic ratio between the posterior and prior distributions. Optimizing this utility function enables us to design experiments that yield the most informative data about the model parameters. One of the major difficulties in evaluating the expected information gain is that it naturally involves nested integration over a possibly high dimensional domain. We use the Multilevel Monte Carlo (MLMC) method to accelerate the computation of the nested high dimensional integral. The advantages are twofold. First, MLMC can significantly reduce the cost of the nested integral for a given tolerance, by using an optimal sample distribution among different sample averages of the inner integrals. Second, the MLMC method imposes fewer assumptions, such as the asymptotic concentration of posterior measures, required for instance by the Laplace approximation (LA). We test the MLMC method using two numerical examples. The first example is the design of sensor deployment for a Darcy flow problem governed by a one-dimensional Poisson equation. We place the sensors in the locations where the pressure is measured, and we model the conductivity field as a piecewise constant random vector with two parameters. The second one is chemical Enhanced Oil Recovery (EOR) core flooding experiment assuming homogeneous permeability. We measure the cumulative oil recovery, from a horizontal core flooded by water, surfactant and polymer, for different injection rates. The model parameters consist of the endpoint relative permeabilities, the residual saturations and the relative permeability exponents for the three phases: water, oil and

  2. Design and construction of the IEA Grimethorpe experimental facility

    Energy Technology Data Exchange (ETDEWEB)

    Broadbent, D.H.; Wright, S.J.; Kaden, M.

    1979-06-01

    In December 1975 the Governments of the United Kingdom, the United States of America, and the Federal Republic of Germany, under the auspices of the International Energy Agency, entered into an agreement to build a large pressurized fluidized bed combustion experimental facility. The function of the facility would be to extend the range of fluidization and combustion characteristics investigated from those of the relatively small rigs then in operation across the whole range of conditions potentially applicable to combined cycle power generation systems. The ranges of conditions to be investigated in the facility are pressures 6 to 12 bar, fluidizing velocity 0.6 to 3.0 m/s and bed temperatures 750 to 950/sup 0/C. The ultimate aim is to seek an optimum condition and establish a data base from which a demonstration plant could be designed and built.

  3. Statistics in experimental design, preprocessing, and analysis of proteomics data.

    Science.gov (United States)

    Jung, Klaus

    2011-01-01

    High-throughput experiments in proteomics, such as 2-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS), yield usually high-dimensional data sets of expression values for hundreds or thousands of proteins which are, however, observed on only a relatively small number of biological samples. Statistical methods for the planning and analysis of experiments are important to avoid false conclusions and to receive tenable results. In this chapter, the most frequent experimental designs for proteomics experiments are illustrated. In particular, focus is put on studies for the detection of differentially regulated proteins. Furthermore, issues of sample size planning, statistical analysis of expression levels as well as methods for data preprocessing are covered.

  4. An experimental design method leading to chemical Turing patterns.

    Science.gov (United States)

    Horváth, Judit; Szalai, István; De Kepper, Patrick

    2009-05-08

    Chemical reaction-diffusion patterns often serve as prototypes for pattern formation in living systems, but only two isothermal single-phase reaction systems have produced sustained stationary reaction-diffusion patterns so far. We designed an experimental method to search for additional systems on the basis of three steps: (i) generate spatial bistability by operating autoactivated reactions in open spatial reactors; (ii) use an independent negative-feedback species to produce spatiotemporal oscillations; and (iii) induce a space-scale separation of the activatory and inhibitory processes with a low-mobility complexing agent. We successfully applied this method to a hydrogen-ion autoactivated reaction, the thiourea-iodate-sulfite (TuIS) reaction, and noticeably produced stationary hexagonal arrays of spots and parallel stripes of pH patterns attributed to a Turing bifurcation. This method could be extended to biochemical reactions.

  5. Handbook on advanced design and manufacturing technologies for biomedical devices

    CERN Document Server

    2013-01-01

    The last decades have seen remarkable advances in computer-aided design, engineering and manufacturing technologies, multi-variable simulation tools, medical imaging, biomimetic design, rapid prototyping, micro and nanomanufacturing methods and information management resources, all of which provide new horizons for the Biomedical Engineering fields and the Medical Device Industry. Handbook on Advanced Design and Manufacturing Technologies for Biomedical Devices covers such topics in depth, with an applied perspective and providing several case studies that help to analyze and understand the key factors of the different stages linked to the development of a novel biomedical device, from the conceptual and design steps, to the prototyping and industrialization phases. Main research challenges and future potentials are also discussed, taking into account relevant social demands and a growing market already exceeding billions of dollars. In time, advanced biomedical devices will decisively change methods and resu...

  6. Designing Technology for Active Spectator Experiences at Sporting Events

    DEFF Research Database (Denmark)

    Veerasawmy, Rune; Ludvigsen, Martin

    is not merely an experience of receiving and consuming entertainment. It is also heavily reliant on the active participation of the spectator in creating the atmosphere of the entire event. The BannerBattle experiment provides interactive technology in sport arenas with a form of interaction based on existing......This paper explores the active spectator experience at sporting events, by presenting and reflecting upon a design experiment carried out at a number of football1 events. The initial hypothesis of the design process, leading to the design experiment has been that the spectator experience...... behaviour in the context. The work presented also argues for a need to overcome the inclination to designing technological systems that imitate or compete with the experience of watching the television broadcast of the game. Experiments such as the presented BannerBattle are cornerstones in our exploratory...

  7. Design technologies for green and sustainable computing systems

    CERN Document Server

    Ganguly, Amlan; Chakrabarty, Krishnendu

    2013-01-01

    This book provides a comprehensive guide to the design of sustainable and green computing systems (GSC). Coverage includes important breakthroughs in various aspects of GSC, including multi-core architectures, interconnection technology, data centers, high-performance computing (HPC), and sensor networks. The authors address the challenges of power efficiency and sustainability in various contexts, including system design, computer architecture, programming languages, compilers and networking. ·         Offers readers a single-source reference for addressing the challenges of power efficiency and sustainability in embedded computing systems; ·         Provides in-depth coverage of the key underlying design technologies for green and sustainable computing; ·         Covers a wide range of topics, from chip-level design to architectures, computing systems, and networks.

  8. Simulation-based optimal Bayesian experimental design for nonlinear systems

    KAUST Repository

    Huan, Xun

    2013-01-01

    The optimal selection of experimental conditions is essential to maximizing the value of data for inference and prediction, particularly in situations where experiments are time-consuming and expensive to conduct. We propose a general mathematical framework and an algorithmic approach for optimal experimental design with nonlinear simulation-based models; in particular, we focus on finding sets of experiments that provide the most information about targeted sets of parameters.Our framework employs a Bayesian statistical setting, which provides a foundation for inference from noisy, indirect, and incomplete data, and a natural mechanism for incorporating heterogeneous sources of information. An objective function is constructed from information theoretic measures, reflecting expected information gain from proposed combinations of experiments. Polynomial chaos approximations and a two-stage Monte Carlo sampling method are used to evaluate the expected information gain. Stochastic approximation algorithms are then used to make optimization feasible in computationally intensive and high-dimensional settings. These algorithms are demonstrated on model problems and on nonlinear parameter inference problems arising in detailed combustion kinetics. © 2012 Elsevier Inc.

  9. A retrospective mathematical analysis of controlled release design and experimentation.

    Science.gov (United States)

    Rothstein, Sam N; Kay, Jennifer E; Schopfer, Francisco J; Freeman, Bruce A; Little, Steven R

    2012-11-01

    The development and performance evaluation of new biodegradable polymer controlled release formulations relies on successful interpretation and evaluation of in vitro release data. However, depending upon the extent of empirical characterization, release data may be open to more than one qualitative interpretation. In this work, a predictive model for release from degradable polymer matrices was applied to a number of published release data in order to extend the characterization of release behavior. Where possible, the model was also used to interpolate and extrapolate upon collected released data to clarify the overall duration of release and also kinetics of release between widely spaced data points. In each case examined, mathematical predictions of release coincide well with experimental results, offering a more definitive description of each formulation's performance than was previously available. This information may prove particularly helpful in the design of future studies, such as when calculating proper dosing levels or determining experimental end points in order to more comprehensively evaluate a controlled release system's performance.

  10. Experimental Verification of Current Shear Design Equations for HSRC Beams

    Directory of Open Access Journals (Sweden)

    Attaullah Shah

    2012-07-01

    Full Text Available Experimental research on the shear capacity of HSRC (High Strength Reinforced Concrete beams is relatively very limited as compared to the NSRC (Normal Strength Reinforced Concrete beams. Most of the Building Codes determine the shear strength of HSRC with the help of empirical equations based on experimental work of NSRC beams and hence these equations are generally regarded as un-conservative for HSRC beams particularly at low level of longitudinal reinforcement. In this paper, 42 beams have been tested in two sets, such that in 21 beams no transverse reinforcement has been used, whereas in the remaining 21 beams, minimum transverse reinforcement has been used as per ACI-318 (American Concrete Institute provisions. Two values of compressive strength 52 and 61 MPa, three values of longitudinal steel ratio and seven values of shear span to depth ratio have been have been used. The beams were tested under concentrated load at the mid span. The results are compared with the equations proposed by different international building codes like ACI, AASHTO LRFD, EC (Euro Code, Canadian Code and Japanese Code for shear strength of HSRC beams.From comparison, it has been observed that some codes are less conservative for shear design of HSRC beams and further research is required to rationalize these equations.

  11. Application of Multimedia and Internet Technology in Learning Mould Design

    Institute of Scientific and Technical Information of China (English)

    Simon; S; P; Shum

    2002-01-01

    With the use of multimedia which combines the use o f text, sound, images, motion video and animation, it is more efficient for studen ts to learn mould design interactively. A program is created using several multi media software to simulate the mechanism of moulding processes in order to let s tudents understand the concept of mould design. In addition, students can even access the program through the Internet. Therefore, the software is defined as Multimedia and Internet Technology (MIT) program. T...

  12. Research on animation design of growing plant based on 3D MAX technology

    Science.gov (United States)

    Chen, Yineng; Fang, Kui; Bu, Weiqiong; Zhang, Xiaoling; Lei, Menglong

    In view of virtual plant has practical demands on quality, image and degree of realism animation in growing process of plant, this thesis design the animation based on mechanism and regularity of plant growth, and propose the design method based on 3D MAX technology. After repeated analysis and testing, it is concluded that there are modeling, rendering, animation fabrication and other key technologies in the animation design process. Based on this, designers can subdivid the animation into seed germination animation, plant growth prophase animation, catagen animation, later animation and blossom animation. This paper compounds the animation of these five stages by VP window to realize the completed 3D animation. Experimental result shows that the animation can realized rapid, visual and realistic simulatation the plant growth process.

  13. Development of design technology for system - integrated modular advanced react or (SMART) /technology support of NSSS design for SMART

    Energy Technology Data Exchange (ETDEWEB)

    Joon, Hah Yung; Kim, Kee Eun [KOPEC, Taejeon (Korea)

    2002-03-01

    SMART design concept is very different from that of the commercial PWRs, as the main components such as the steam generator, pressurizer, and the main coolant pumps are incorporate the related sub-part systems into the reactor vessel. In this report the design for SMART is the basic design stage and is the new design technology development task for the first trial in Korea. KOPEC NED has participated with Korea Atomic Energy Research Institute for the task of 'Development of Design Technology for SMART' as supporting sub-task of it. The system design (ECCS, Makeup and Purification System), mechanical design (Seismic Analysis, BLPB Analysis, Structural Analysis, Design Load Calculation, Stress Fatigue Evaluation, Fracture Mechanical and Structural Integrity Evaluation), MMIS design (Alarm and Indication System, Information Processing System, Large Display Panel, Human System Interface Guideline) have been performed as a basic design for SMART during 31 months (1999. 9.1{approx}2002.3.31). This report is the final one for the support of the main task of Korea Atomic Energy Research Institute. 124 refs., 154 figs., 97 tabs. (Author)

  14. Quasi-experimental designs in practice-based research settings: design and implementation considerations.

    Science.gov (United States)

    Handley, Margaret A; Schillinger, Dean; Shiboski, Stephen

    2011-01-01

    Although randomized controlled trials are often a gold standard for determining intervention effects, in the area of practice-based research (PBR), there are many situations in which individual randomization is not possible. Alternative approaches to evaluating interventions have received increased attention, particularly those that can retain elements of randomization such that they can be considered "controlled" trials. Methodological design elements and practical implementation considerations for two quasi-experimental design approaches that have considerable promise in PBR settings--the stepped-wedge design, and a variant of this design, a wait-list cross-over design, are presented along with a case study from a recent PBR intervention for patients with diabetes. PBR-relevant design features include: creation of a cohort over time that collects control data but allows all participants (clusters or patients) to receive the intervention; staggered introduction of clusters; multiple data collection points; and one-way cross-over into the intervention arm. Practical considerations include: randomization versus stratification, training run in phases; and extended time period for overall study completion. Several design features of practice based research studies can be adapted to local circumstances yet retain elements to improve methodological rigor. Studies that utilize these methods, such as the stepped-wedge design and the wait-list cross-over design, can increase the evidence base for controlled studies conducted within the complex environment of PBR.

  15. MicroarrayDesigner: an online search tool and repository for near-optimal microarray experimental designs

    Directory of Open Access Journals (Sweden)

    Ferhatosmanoglu Nilgun

    2009-09-01

    Full Text Available Abstract Background Dual-channel microarray experiments are commonly employed for inference of differential gene expressions across varying organisms and experimental conditions. The design of dual-channel microarray experiments that can help minimize the errors in the resulting inferences has recently received increasing attention. However, a general and scalable search tool and a corresponding database of optimal designs were still missing. Description An efficient and scalable search method for finding near-optimal dual-channel microarray designs, based on a greedy hill-climbing optimization strategy, has been developed. It is empirically shown that this method can successfully and efficiently find near-optimal designs. Additionally, an improved interwoven loop design construction algorithm has been developed to provide an easily computable general class of near-optimal designs. Finally, in order to make the best results readily available to biologists, a continuously evolving catalog of near-optimal designs is provided. Conclusion A new search algorithm and database for near-optimal microarray designs have been developed. The search tool and the database are accessible via the World Wide Web at http://db.cse.ohio-state.edu/MicroarrayDesigner. Source code and binary distributions are available for academic use upon request.

  16. Experimental annotation of the human genome using microarray technology.

    Science.gov (United States)

    Shoemaker, D D; Schadt, E E; Armour, C D; He, Y D; Garrett-Engele, P; McDonagh, P D; Loerch, P M; Leonardson, A; Lum, P Y; Cavet, G; Wu, L F; Altschuler, S J; Edwards, S; King, J; Tsang, J S; Schimmack, G; Schelter, J M; Koch, J; Ziman, M; Marton, M J; Li, B; Cundiff, P; Ward, T; Castle, J; Krolewski, M; Meyer, M R; Mao, M; Burchard, J; Kidd, M J; Dai, H; Phillips, J W; Linsley, P S; Stoughton, R; Scherer, S; Boguski, M S

    2001-02-15

    The most important product of the sequencing of a genome is a complete, accurate catalogue of genes and their products, primarily messenger RNA transcripts and their cognate proteins. Such a catalogue cannot be constructed by computational annotation alone; it requires experimental validation on a genome scale. Using 'exon' and 'tiling' arrays fabricated by ink-jet oligonucleotide synthesis, we devised an experimental approach to validate and refine computational gene predictions and define full-length transcripts on the basis of co-regulated expression of their exons. These methods can provide more accurate gene numbers and allow the detection of mRNA splice variants and identification of the tissue- and disease-specific conditions under which genes are expressed. We apply our technique to chromosome 22q under 69 experimental condition pairs, and to the entire human genome under two experimental conditions. We discuss implications for more comprehensive, consistent and reliable genome annotation, more efficient, full-length complementary DNA cloning strategies and application to complex diseases.

  17. Optics Design for the U.S. SKA Technology Development Project Design Verification Antenna

    Science.gov (United States)

    Imbriale, W. A.; Baker, L.; Cortes-Medellin, G.

    2012-01-01

    The U.S. design concept for the Square Kilometer Array (SKA) program is based on utilizing a large number of 15 meter dish antennas. The Technology Development Project (TDP) is planning to design and build the first of these antennas to provide a demonstration of the technology and a solid base on which to estimate costs. This paper describes the performance of the selected optics design. It is a dual-shaped offset Gregorian design with a feed indexer that can accommodate corrugated horns, wide band single pixel feeds or phased array feeds.

  18. Optics Design for the U.S. SKA Technology Development Project Design Verification Antenna

    Science.gov (United States)

    Imbriale, W. A.; Baker, L.; Cortes-Medellin, G.

    2012-01-01

    The U.S. design concept for the Square Kilometer Array (SKA) program is based on utilizing a large number of 15 meter dish antennas. The Technology Development Project (TDP) is planning to design and build the first of these antennas to provide a demonstration of the technology and a solid base on which to estimate costs. This paper describes the performance of the selected optics design. It is a dual-shaped offset Gregorian design with a feed indexer that can accommodate corrugated horns, wide band single pixel feeds or phased array feeds.

  19. Estimating Intervention Effects across Different Types of Single-Subject Experimental Designs: Empirical Illustration

    Science.gov (United States)

    Moeyaert, Mariola; Ugille, Maaike; Ferron, John M.; Onghena, Patrick; Heyvaert, Mieke; Beretvas, S. Natasha; Van den Noortgate, Wim

    2015-01-01

    The purpose of this study is to illustrate the multilevel meta-analysis of results from single-subject experimental designs of different types, including AB phase designs, multiple-baseline designs, ABAB reversal designs, and alternating treatment designs. Current methodological work on the meta-analysis of single-subject experimental designs…

  20. Design and Testing of CO2 Compression Using Supersonic Shock Wave Technology

    Energy Technology Data Exchange (ETDEWEB)

    Koopman, Aaron [Seattle Technology Center, Bellevue, WA (United States)

    2015-06-01

    This report summarizes work performed by Ramgen and subcontractors in pursuit of the design and construction of a 10 MW supersonic CO2 compressor and supporting facility. The compressor will demonstrate application of Ramgen’s supersonic compression technology at an industrial scale using CO2 in a closed-loop. The report includes details of early feasibility studies, CFD validation and comparison to experimental data, static test experimental results, compressor and facility design and analyses, and development of aerodynamic tools. A summary of Ramgen's ISC Engine program activity is also included. This program will demonstrate the adaptation of Ramgen's supersonic compression and advanced vortex combustion technology to result in a highly efficient and cost effective alternative to traditional gas turbine engines. The build out of a 1.5 MW test facility to support the engine and associated subcomponent test program is summarized.

  1. Mobilizing Senior Citizens in Co-Design of Mobile Technology

    DEFF Research Database (Denmark)

    Malmborg, Lone; Gronvall, Erik; Messeter, Jörn

    2016-01-01

    &Take project. Challenges for mobilization are identified, based on an analysis of attitudes and values among design researchers and senior citizens. This analysis lead us to identify and discuss three strategies for mobilizing senior citizens in co-design of mobile technology: 1) Understanding being ‘elderly......This paper disseminates work from the European Give&Take project, which aims at co-designing service sharing among senior citizens based on a mobile and distributed platform. With this project as a frame, our paper addresses methodological considerations of participation in co-design for ageing....... Based on the notions of design culture, communities of everyday practice and situated elderliness we present accounts from two European countries, and discuss methodological issues related to mobilizing senior citizens in co-design work as they have manifested themselves and influenced the Give...

  2. Large-scale experimental design for decentralized SLAM

    Science.gov (United States)

    Cunningham, Alex; Dellaert, Frank

    2012-06-01

    This paper presents an analysis of large scale decentralized SLAM under a variety of experimental conditions to illustrate design trade-offs relevant to multi-robot mapping in challenging environments. As a part of work through the MAST CTA, the focus of these robot teams is on the use of small-scale robots with limited sensing, communication and computational resources. To evaluate mapping algorithms with large numbers (50+) of robots, we developed a simulation incorporating sensing of unlabeled landmarks, line-of-sight blocking obstacles, and communication modeling. Scenarios are randomly generated with variable models for sensing, communication, and robot behavior. The underlying Decentralized Data Fusion (DDF) algorithm in these experiments enables robots to construct a map of their surroundings by fusing local sensor measurements with condensed map information from neighboring robots. Each robot maintains a cache of previously collected condensed maps from neighboring robots, and actively distributes these maps throughout the network to ensure resilience to communication and node failures. We bound the size of the robot neighborhoods to control the growth of the size of neighborhood maps. We present the results of experiments conducted in these simulated scenarios under varying measurement models and conditions while measuring mapping performance. We discuss the trade-offs between mapping performance and scenario design, including robot teams separating and joining, multi-robot data association, exploration bounding, and neighborhood sizes.

  3. Staging Co-design Processes for Self-care Technologies

    DEFF Research Database (Denmark)

    Brodersen, Søsser Grith Kragh; Lindegaard, Hanne

    2016-01-01

    Many new healthcare technologies are currently being implemented in people’s homes in order to facilitate self-care. Socially innovative design is challenging, since it requires an intimate understanding of people’s abilities and daily practices. In this article, we highlight the need to perform...

  4. Design of a technology centre: A Vehicle for Industrial Development ...

    African Journals Online (AJOL)

    This paper deals with the design of a Technology Centre to meet the needs of industries ... The article addresses problems and constraints of industries in developing ... point system method while the product families are chosen using ranking method. ... for manufacturing, training, consultancy, maintenance and distribution.

  5. Continuous-Flow Biochips: Technology, Physical Design Methods and Testing

    DEFF Research Database (Denmark)

    Pop, Paul; Araci, Ismail Emre; Chakrabarty, Krishnendu

    2015-01-01

    This article is a tutorial on continuous-flow biochips where the basic building blocks are microchannels, and microvalves, and by combining them, more complex units such as mixers, switches, and multiplexers can be built. It also presents the state of the art in flow-based biochip technology...... and emerging research challenges in the areas of physical design and testing techniques....

  6. Designing Technology for Content-Independent Collaborative Mobile Learning

    Science.gov (United States)

    Boticki, I.; Wong, Lung Hsiang; Looi, Chee-Kit

    2013-01-01

    This paper describes the design of a technology platform for supporting content-independent collaborative mobile learning in the classroom. The technical architecture provides mechanisms for assigning different content or materials to students and then guiding them to form groups with other students in which the combination and integration of…

  7. Information technology aided exploration of system design spaces

    Science.gov (United States)

    Feather, Martin S.; Kiper, James D.; Kalafat, Selcuk

    2004-01-01

    We report on a practical application of information technology techniques to aid system engineers effectively explore large design spaces. We make use of heuristic search, visualization and data mining, the combination of which we have implemented wtihin a risk management tool in use at JPL and NASA.

  8. A Review of Research Methods in Children's Technology Design

    DEFF Research Database (Denmark)

    Jensen, Janne Jul; Skov, Mikael B.

    2005-01-01

    -ences on the discipline. Inspired by previous studies from other disciplines, we conduct a survey of research methods in paper publications. 105 papers on children's technology design are classified on a two-dimensional matrix on research method and pur-pose. Our results show a strong focus on engineering of products...

  9. Business Studies within Design and Technology: Continuity and Progression.

    Science.gov (United States)

    Mathews, Maggie; Swainston, David

    1992-01-01

    Explores the placement of business studies courses within design and technology education programs in the United Kingdom. Reports the sense of isolation felt by business educators. Suggests a progression by which economic concepts could be taught on the various grade levels. Calls for further discussion of the proposal. (SG)

  10. Technology-Enhanced EFL Syllabus Design and Materials Development

    Science.gov (United States)

    Nguyen, Long V.

    2008-01-01

    In this paper, I am going to look at the issues of TESOL from one major critical point of view: How the use of the Internet technology might influence TESOL syllabus design and materials development. The article attempts to investigate some possibilities and opportunities provided by the Internet, focusing on the World Wide Web (WWW) as credible…

  11. Designing technology for emergent literacy: the PictoPal initiative

    NARCIS (Netherlands)

    McKenney, Susan; Voogt, Joke

    2009-01-01

    PictoPal is the name of a technology-supported intervention designed to foster the development of emergent reading and writing skills in four and five year old children. Following the theoretical underpinnings and a brief description of PictoPal, this article describes how children worked with the t

  12. Designing technology for emergent literacy: the PictoPal initiative

    NARCIS (Netherlands)

    McKenney-Jensh, Susan E.; Voogt, Joke

    2009-01-01

    PictoPal is the name of a technology-supported intervention designed to foster the development of emergent reading and writing skills in four and five year old children. Following the theoretical underpinnings and a brief description of PictoPal, this article describes how children worked with the

  13. Using particle packing technology for sustainable concrete mixture design

    NARCIS (Netherlands)

    Fennis, S.A.A.M.; Walraven, J.C.

    2012-01-01

    The annual production of Portland cement, estimated at 3.4 billion tons in 2011, is responsible for about 7% of the total worldwide CO2-emission. To reduce this environmental impact it is important to use innovative technologies for the design of concrete structures and mixtures. In this paper, it i

  14. Design Based Research Methodology for Teaching with Technology in English

    Science.gov (United States)

    Jetnikoff, Anita

    2015-01-01

    Design based research (DBR) is an appropriate method for small scale educational research projects involving collaboration between teachers, students and researchers. It is particularly useful in collaborative projects where an intervention is implemented and evaluated in a grounded context. The intervention can be technological, or a new program…

  15. What Does Design and Technology Learning Really Look Like?

    Science.gov (United States)

    Southall, Mary

    2016-01-01

    This paper presents findings from a research study investigating the relationship between "intended" learning and "actual" learning in Design and Technology lessons (Southall, 2015). The research focused upon the "pre active" phase of the teaching-learning process, that is the teacher's planning processes and…

  16. The General Design and Technology Innovations of CAP1400

    Directory of Open Access Journals (Sweden)

    Mingguang Zheng

    2016-03-01

    Full Text Available The pressurized water reactor CAP1400 is one of the sixteen National Science and Technology Major Projects. Developed from China's nuclear R&D system and manufacturing capability, as well as AP1000 technology introduction and assimilation, CAP1400 is an advanced large passive nuclear power plant with independent intellectual property rights. By discussing the top design principle, main performance objectives, general parameters, safety design, and important improvements in safety, economy, and other advanced features, this paper reveals the technology innovation and competitiveness of CAP1400 as an internationally promising Gen-III PWR model. Moreover, the R&D of CAP1400 has greatly promoted China's domestic nuclear power industry from the Gen-II to the Gen-III level.

  17. Numerical and experimental design of coaxial shallow geothermal energy systems

    Science.gov (United States)

    Raghavan, Niranjan

    Geothermal Energy has emerged as one of the front runners in the energy race because of its performance efficiency, abundance and production competitiveness. Today, geothermal energy is used in many regions of the world as a sustainable solution for decreasing dependence on fossil fuels and reducing health hazards. However, projects related to geothermal energy have not received their deserved recognition due to lack of computational tools associated with them and economic misconceptions related to their installation and functioning. This research focuses on numerical and experimental system design analysis of vertical shallow geothermal energy systems. The driving force is the temperature difference between a finite depth beneath the earth and its surface stimulates continuous exchange of thermal energy from sub-surface to the surface (a geothermal gradient is set up). This heat gradient is captured by the circulating refrigerant and thus, tapping the geothermal energy from shallow depths. Traditionally, U-bend systems, which consist of two one-inch pipes with a U-bend connector at the bottom, have been widely used in geothermal applications. Alternative systems include coaxial pipes (pipe-in-pipe) that are the main focus of this research. It has been studied that coaxial pipes have significantly higher thermal performance characteristics than U-bend pipes, with comparative production and installation costs. This makes them a viable design upgrade to the traditional piping systems. Analytical and numerical heat transfer analysis of the coaxial system is carried out with the help of ABAQUS software. It is tested by varying independent parameters such as materials, soil conditions and effect of thermal contact conductance on heat transfer characteristics. With the above information, this research aims at formulating a preliminary theoretical design setup for an experimental study to quantify and compare the heat transfer characteristics of U-bend and coaxial

  18. Quasi-experimental study designs series - paper 1: history and introduction.

    Science.gov (United States)

    Bärnighausen, Till; Røttingen, John-Arne; Rockers, Peter; Shemilt, Ian; Tugwell, Peter

    2017-07-07

    To contrast the historical development of experiments and quasi-experiments and provide the motivation for a journal series on quasi-experimental designs in health research STUDY DESIGN: A short historical narrative, with concrete examples, and arguments based on an understanding of the practice of health research and evidence synthesis RESULTS: Health research has played a key role in developing today's gold standard for causal inference - the randomized controlled multiply blinded trial. Historically, allocation approaches developed from convenience and purposive allocation to alternate and, finally, to random allocation. This development was motivated both by concerns for manipulation in allocation as well as statistical and theoretical developments demonstrating the power of randomization in creating counterfactuals for causal inference. In contrast to the sequential development of experiments, quasi-experiments originated at very different points in time, from very different scientific perspectives, and with frequent and long interruptions in their methodological development. Health researchers have only recently started to recognize the value of quasi-experiments for generating novel insights on causal relationships. While quasi-experiments are unlikely to replace experiments in generating the efficacy and safety evidence required for clinical guidelines and regulatory approval of medical technologies, quasi-experiments can play an important role in establishing the effectiveness of healthcare practice, programs and policies. The papers in this series describe and discuss a range of important issues in utilizing quasi-experimental designs for primary research and quasi-experimental results for evidence synthesis. Copyright © 2017. Published by Elsevier Inc.

  19. The vacuum system for technological unit development and design

    Science.gov (United States)

    Zhukeshov, A. M.; Gabdullina, A. T.; Amrenova, A. U.; Giniyatova, Sh G.; Kaibar, A.; Sundetov, A.; Fermakhan, K.

    2015-11-01

    The paper shows results of development of plasma technological unit on the basis of accelerator of vacuum arc and automated system. During the previous years, the authors investigated the operation of pulsed plasma accelerator and developed unique technologies for hardening of materials. Principles of plasma formation in pulsed plasma accelerator were put into basis of the developed unit. Operation of the pulsed arc accelerator was investigated at different parameters of the charge. The developed vacuum system is designed for production of hi-tech plasma units in high technologies in fields of nanomaterials, mechanical and power engineering and production with high added value. Unlike integrated solutions, the system is a module one to allow its low cost, high reliability and simple maintenance. The problems of use of robots are discussed to modernize the technological process.

  20. Additive manufacturing of metals the technology, materials, design and production

    CERN Document Server

    Yang, Li; Baughman, Brian; Godfrey, Donald; Medina, Francisco; Menon, Mamballykalathil; Wiener, Soeren

    2017-01-01

    This book offers a unique guide to the three-dimensional (3D) printing of metals. It covers various aspects of additive, subtractive, and joining processes used to form three-dimensional parts with applications ranging from prototyping to production. Examining a variety of manufacturing technologies and their ability to produce both prototypes and functional production-quality parts, the individual chapters address metal components and discuss some of the important research challenges associated with the use of these technologies. As well as exploring the latest technologies currently under development, the book features unique sections on electron beam melting technology, material lifting, and the importance this science has in the engineering context. Presenting unique real-life case studies from industry, this book is also the first to offer the perspective of engineers who work in the field of aerospace and transportation systems, and who design components and manufacturing networks. Written by the leadin...

  1. Experimental subjects and partial truth telling during technological change in radiotherapy.

    Science.gov (United States)

    Wood, Lisa Anne

    2017-06-01

    Cone Beam Computed Tomography (CBCT), the focus of a number of radiotherapy fundraising campaigns in the mid-2000s, was introduced accompanied by a fanfare of newness and discourses of 'hope', 'inspiring clinical confidence' and 'accuracy'. The CBCT system, used in the delivery of Radiotherapy treatment, was incorporated into strategic planning priorities across the United Kingdom based on a rationale of self-evidence. During this time, the way in which the new system was discussed with patients was variable. The purpose of this study was to uncover how experimental practices were embedded and enacted during the use of a new technological system, specifically relating to how patients were enrolled during introductory phases of technology adoption. Research design and context: Drawing on ethnographic work and interviews with staff members in one hospital, the study examines staff discussions prior to the introduction of the Cone-Beam CT imaging system in radiotherapy. It considers how staff views were at odds with practices that occurred during the 'experimental' stages of use and how these were shared with patients. Ethical considerations: Approval was obtained from the Local National Health Service Research Ethics Committee and National Health Service Main Research Ethics Committee (REC 07/Q1308/16) for the interview and ethnographic stages, respectively. All names have been changed and participants signed a consent form. Staff reported a lack of evidence, absence of proof and perturbing doubts with the X-ray volumetric imaging. Both patients' and practitioners' partial understanding about the risks and benefits of the system created incommensurable ideas regarding its use and what the patients' role was during these introductory stages. Maintaining partial truth telling renders patients' experiences of new treatment at odds with 'experimental' practice. This has wide-reaching implications for practice.

  2. Adaptive Controller Design for Faulty UAVs via Quantum Information Technology

    Directory of Open Access Journals (Sweden)

    Fuyang Chen

    2012-12-01

    Full Text Available In this paper, an adaptive controller is designed for a UAV flight control system against faults and parametric uncertainties based on quantum information technology and the Popov hyperstability theory. First, considering the bounded control input, the state feedback controller is designed to make the system stable. The model of adaptive control is introduced to eliminate the impact by the uncertainties of system parameters via quantum information technology. Then, according to the model reference adaptive principle, an adaptive control law based on the Popov hyperstability theory is designed. This law enable better robustness of the flight control system and tracking control performances. The closed-loop system's stability is guaranteed by the Popov hyperstability theory. The simulation results demonstrate that a better dynamic performance of the UAV flight control system with faults and parametric uncertainties can be maintained with the proposed method.

  3. Designs and Technology Requirements for Civil Heavy Lift Rotorcraft

    Science.gov (United States)

    Johnson, Wayne; Yamauchi, Gloria K.; Watts, Michael E.

    2006-01-01

    The NASA Heavy Lift Rotorcraft Systems Investigation examined in depth several rotorcraft configurations for large civil transport, designed to meet the technology goals of the NASA Vehicle Systems Program. The investigation identified the Large Civil Tiltrotor as the configuration with the best potential to meet the technology goals. The design presented was economically competitive, with the potential for substantial impact on the air transportation system. The keys to achieving a competitive aircraft were low drag airframe and low disk loading rotors; structural weight reduction, for both airframe and rotors; drive system weight reduction; improved engine efficiency; low maintenance design; and manufacturing cost comparable to fixed-wing aircraft. Risk reduction plans were developed to provide the strategic direction to support a heavy-lift rotorcraft development. The following high risk areas were identified for heavy lift rotorcraft: high torque, light weight drive system; high performance, structurally efficient rotor/wing system; low noise aircraft; and super-integrated vehicle management system.

  4. Adaptive Controller Design for Faulty UAVs via Quantum Information Technology

    Directory of Open Access Journals (Sweden)

    Fuyang Chen

    2012-12-01

    Full Text Available In this paper, an adaptive controller is designed for a UAV flight control system against faults and parametric uncertainties based on quantum information technology and the Popov hyperstability theory. First, considering the bounded control input, the state feedback controller is designed to make the system stable. The model of adaptive control is introduced to eliminate the impact by the uncertainties of system parameters via quantum information technology. Then, according to the model reference adaptive principle, an adaptive control law based on the Popov hyperstability theory is designed. This law enable better robustness of the flight control system and tracking control performances. The closed‐loop system’s stability is guaranteed by the Popov hyperstability theory. The simulation results demonstrate that a better dynamic performance of the UAV flight control system with faults and parametric uncertainties can be maintained with the proposed method.

  5. Staging Co-design Processes for Self-care Technologies

    DEFF Research Database (Denmark)

    Brodersen, Søsser Grith Kragh; Lindegaard, Hanne

    2016-01-01

    Many new healthcare technologies are currently being implemented in people’s homes in order to facilitate self-care. Socially innovative design is challenging, since it requires an intimate understanding of people’s abilities and daily practices. In this article, we highlight the need to perform...... field studies in people’s homes and discuss how to stage design processes with the people who are actually going to use the self-care technologies—not only end-users, but also many other actors, such as relatives, caregivers, and municipality and company staff. Specifically, we describe how challenges...... associated with inscribing selfcare into healthcare technologies can be overcome by staging co-design proces...

  6. Helical channel design and technology for cooling of muon beams

    CERN Document Server

    Yonehara, K; Johnson, R P

    2012-01-01

    Novel magnetic helical channel designs for capture and cooling of bright muon beams are being developed using numerical simulations based on new inventions such as helical solenoid (HS) magnets and hydrogen-pressurized RF (HPRF) cavities. We are close to the factor of a million six-dimensional phase space (6D) reduction needed for muon colliders. Recent experimental and simulation results are presented.

  7. Statistical vs. stochastic experimental design: an experimental comparison on the example of protein refolding.

    Science.gov (United States)

    Anselment, Bernd; Schoemig, Veronika; Kesten, Christopher; Weuster-Botz, Dirk

    2012-01-01

    Optimization of experimental problems is a challenging task in both engineering and science. In principle, two different design of experiments (DOE) strategies exist: statistical and stochastic methods. Both aim to efficiently and precisely identify optimal solutions inside the problem-specific search space. Here, we evaluate and compare both strategies on the same experimental problem, the optimization of the refolding conditions of the lipase from Thermomyces lanuginosus with 26 variables under study. Protein refolding is one of the main bottlenecks in the process development for recombinant proteins. Despite intensive effort, the prediction of refolding from sequence information alone is still not applicable today. Instead, suitable refolding conditions are typically derived empirically in large screening experiments. Thus, protein refolding should constitute a good performance test for DOE strategies. We compared an iterative stochastic optimization applying a genetic algorithm and a standard statistical design consisting of a D-optimal screening step followed by an optimization via response surface methodology. Our results revealed that only the stochastic optimization was able to identify optimal refolding conditions (~1.400 U g(-1) refolded activity), which were 3.4-fold higher than the standard. Additionally, the stochastic optimization proved quite robust, as three independent optimizations performed similar. In contrast, the statistical DOE resulted in a suboptimal solution and failed to identify comparable activities. Interactions between process variables proved to be pivotal for this optimization. Hence, the linear screening model was not able to identify the most important process variables correctly. Thereby, this study highlighted the limits of the classic two-step statistical DOE.

  8. Experimental study on MSW gasification and melting technology

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    In order to develop municipal solid waste (MSW) gasification and melting technology, two preliminary experiments and a principle integrated experiment were fulfilled respectively. The gasification characteristics of MSW are studied at 500-750℃ when equivalence ratio (ER) was 0.2-0.5 using a fluidized-bed gasifier. When temperature was 550-700℃ and ER was 0.2-0.4, low heat value (LHV) of syngas reaches 4000-12000 kJ/Nm3. The melting characteristics of fly ash were investigated at 1100-1460℃ using a fixed-bed furnace. It was proved that over 99.9% of dioxins could be decomposed and most heavy-metals could be solidified when temperature was 1100-1300℃. The principle integrated experiment was carried out in a fluidized-bed gasification and swirl-melting system. MSW was gasified efficiently at 550-650℃, swirl-melting furnace maintains at 1200-1300℃ stably and over 95% of fly ash could be caught by the swirl-melting furnace. The results provided much practical experience and basic data to develop MSW gasification and melting technology.

  9. Design considerations in Li/SOCl{sub 2} battery technology

    Energy Technology Data Exchange (ETDEWEB)

    Cieslak, W.R.

    1994-02-01

    Li/SOCl{sub 2} battery technology is attractive by virtue of its high energy density, low self-discharge rate, and ability to to perform well at a wide variety of discharge rates. However, some of these same attributes also make Li/SOCl{sub 2} cells capable of hightly exothermic events when handled under abnormal conditions. We manage the energy safely and optimize the performance by tailoring the design to the application. We have developed three different ``D`` size cells that target low, moderate, and high rate applications. Each design provides safe and efficient performance, although, in progressing from low to high rate capability, the likelihood of venting under abuse conditions increses. We incorporate a vent mechanism in all designs as the ultimate protection from severe abuse. The details of our battery designs and the benefits of application-specific design are discussed.

  10. Technology, recommendation and design: on being a 'paternalistic' philosopher.

    Science.gov (United States)

    Wong, Pak-Hang

    2013-03-01

    Philosophers have talked to each other about moral issues concerning technology, but few of them have talked about issues of technology and the good life, and even fewer have talked about technology and the good life with the public in the form of recommendation. In effect, recommendations for various technologies are often left to technologists and gurus. Given the potential benefits of informing the public on their impacts on the good life, however, this is a curious state of affairs. In the present paper, I will examine why philosophers are seemingly reluctant to offer recommendations to the public. While there are many reasons for philosophers to refrain from offering recommendations, I shall focus on a specific normative reason. More specifically, it appears that, according to a particular definition, offering recommendations can be viewed as paternalistic, and therefore is prima facie wrong to do so. I will provide an argument to show that the worry about paternalism is unfounded, because a form of paternalism engendered by technology is inevitable. Given the inevitability of paternalism, I note that philosophers should accept the duty to offer recommendations to the public. I will then briefly turn to design ethics, which has reconceptualised the role of philosophers and, in my mind, fitted well with the inevitability of paternalism. Finally, I shall argue that design ethics has to be supplemented by the practice of recommendation if it is to sustain its objective.

  11. Designing for older adult users of handheld technology.

    Science.gov (United States)

    Becker, Shirley Ann; Webbe, Frank M

    2006-01-01

    There are few interface design guidelines for handheld devices used by adults sixty years and older. Yet, this growing user group would benefit from the portability offered by such technology in promoting health management and social interaction. In this paper, we describe a usability framework for conducting studies on the use of a PocketPC by older adult caregivers. The usability framework provides a basis for conducting studies taking into account the user profile of an older adult, environment factors, usability quality factors, and technology objectives.

  12. Technology Scaling Impact on Embedded ADC Design for Telecom Receivers

    DEFF Research Database (Denmark)

    Nielsen, Jannik Hammel; Andreani, Pietro; Malcovati, Piero

    2005-01-01

    -frequency, medium-resolution applications. The design of a 10 bit 20 MS/s ADC using the successive approximation algorithm is presented in order to validate the presented concepts. By using a deep-submicron technology, the speed of the chosen architecture is pushed to meet the desired output rate.......This paper is concerned with the impact of technology scaling on the choice of A/D converters in telecom receivers. It is shown that the trend of diminishing feature size, together with better matching of passive components, allows the use of A/D topologies traditionally confined to low...

  13. Experimental Investigation on Complex Structures Machining by Electrochemical Micromachining Technology

    Institute of Scientific and Technical Information of China (English)

    Liu Yong; Zhu Di; Zeng Yongbin; Huang Shaofu; Yu Hongbing

    2010-01-01

    Electrochemical micromachining(EMM)technology for fabricating micro structures is presented in this article.By applying ultra short pulses,dissolution of a workpiece can be restricted to the region very close to the electrode.First,an EMM system for meeting the requirements of the EMM process is established.Second,sets of experiments is carried out to investigate the influence of some of the predominant electrochemical process parameters such as electrical parameters,feed rate,electrode geometry features and electrolyte composition on machining quality,especially the influences of pulse on time on shape precision and working end shape of electrode on machined surface quality.Finally,after the preliminary experiments,a complex microstructure with good shape precision and surface quality is successfully obtained.

  14. Development of fluid system design technology for integral reactor

    Energy Technology Data Exchange (ETDEWEB)

    Lee, D. J.; Chang, M. H.; Kang, D. J. and others

    1999-03-01

    This study presents the technology development of the system design concepts of SMART, a multi-purposed integral reactor with enhanced safety and operability, for use in diverse usages and applications of the nuclear energy. This report contains the following; - Design characteristics - Performance and safety related design criteria - System description: Primary system, Secondary system, Residual heat removal system, Make-up system, Component cooling system, Safety system - Development of design computer code: Steam generator performance(ONCESG), Pressurizer performance(COLDPZR), Steam generator flow instability(SGINS) - Development of component module and modeling using MMS computer code - Design calculation: Steam generator thermal sizing, Analysis of feed-water temperature increase at a low flow rate, Evaluation of thermal efficiency in the secondary system, Inlet orifice throttling coefficient for the prevention of steam generator flow instability, Analysis of Nitrogen gas temperature in the pressurizer during heat-up process, evaluation of water chemistry and erosion etc. The results of this study can be utilized not only for the foundation technology of the next phase basic system design of the SMART but also for the basic model in optimizing the system concepts for future advanced reactors. (author)

  15. Standardization of green building technologies for environment design

    Directory of Open Access Journals (Sweden)

    Benuzh Andrey

    2016-01-01

    Full Text Available The article describes the structure and field of standardization ISO / TC 205 “Building environment design”, provides examples of green building technologies. The main purpose of the article is to show the interaction between international ISO / TC 205 “Building environment design” and created in Russia in 2016 the Technical Committee of Standardization № 366 “Green technology of the build environment and green innovative products”. Both of these technical committees promote green building technologies for environment design, thereby deal with the negative impact on the environment and the reasons of global warming. Instead of buildings that attempt to suppress and overcome nature, why not design buildings that integrate with the environment, on every possible level? The international standardization work which ISO/TC 205 “Building environment design” performs seeks, in addition to lowering trade barriers for engineering design, to promote and facilitate the design of high performance buildings: higher performing as economic assets for their owners, higher performing as buildings that provide amenable indoor environment for their occupants, and higher performing with respect to resource utilization and environmental impact.

  16. Virtual screening and its integration with modern drug design technologies.

    Science.gov (United States)

    Guido, Rafael V C; Oliva, Glaucius; Andricopulo, Adriano D

    2008-01-01

    Drug discovery is a highly complex and costly process, which demands integrated efforts in several relevant aspects involving innovation, knowledge, information, technologies, expertise, R&D investments and management skills. The shift from traditional to genomics- and proteomics-based drug research has fundamentally transformed key R&D strategies in the pharmaceutical industry addressed to the design of new chemical entities as drug candidates against a variety of biological targets. Therefore, drug discovery has moved toward more rational strategies based on our increasing understanding of the fundamental principles of protein-ligand interactions. The combination of available knowledge of several 3D protein structures with hundreds of thousands of small-molecules have attracted the attention of scientists from all over the world for the application of structure- and ligand-based drug design approaches. In this context, virtual screening technologies have largely enhanced the impact of computational methods applied to chemistry and biology and the goal of applying such methods is to reduce large compound databases and to select a limited number of promising candidates for drug design. This review provides a perspective of the utility of virtual screening in drug design and its integration with other important drug discovery technologies such as high-throughput screening (HTS) and QSAR, highlighting the present challenges, limitations, and future perspectives in medicinal chemistry.

  17. Optimal experimental design with the sigma point method.

    Science.gov (United States)

    Schenkendorf, R; Kremling, A; Mangold, M

    2009-01-01

    Using mathematical models for a quantitative description of dynamical systems requires the identification of uncertain parameters by minimising the difference between simulation and measurement. Owing to the measurement noise also, the estimated parameters possess an uncertainty expressed by their variances. To obtain highly predictive models, very precise parameters are needed. The optimal experimental design (OED) as a numerical optimisation method is used to reduce the parameter uncertainty by minimising the parameter variances iteratively. A frequently applied method to define a cost function for OED is based on the inverse of the Fisher information matrix. The application of this traditional method has at least two shortcomings for models that are nonlinear in their parameters: (i) it gives only a lower bound of the parameter variances and (ii) the bias of the estimator is neglected. Here, the authors show that by applying the sigma point (SP) method a better approximation of characteristic values of the parameter statistics can be obtained, which has a direct benefit on OED. An additional advantage of the SP method is that it can also be used to investigate the influence of the parameter uncertainties on the simulation results. The SP method is demonstrated for the example of a widely used biological model.

  18. Tokamak experimental power reactor conceptual design. Volume I

    Energy Technology Data Exchange (ETDEWEB)

    1976-08-01

    A conceptual design has been developed for a tokamak Experimental Power Reactor to operate at net electrical power conditions with a plant capacity factor of 50 percent for 10 years. The EPR operates in a pulsed mode at a frequency of approximately 1/min., with an approximate 75 percent duty cycle, is capable of producing approximately 72 MWe and requires 42 MWe. The annual tritium consumption is 16 kg. The EPR vacuum chamber is 6.25 m in major radius and 2.4 m in minor radius, is constructed of 2-cm thick stainless steel, and has 2-cm thick detachable, beryllium-coated coolant panels mounted on the interior. An 0.28 m stainless steel blanket and a shield ranging from 0.6 to 1.0 m surround the vacuum vessel. The coolant is H/sub 2/O. Sixteen niobium-titanium superconducting toroidal-field coils provide a field of 10 T at the coil and 4.47 T at the plasma. Superconducting ohmic-heating and equilibrium-field coils provide 135 V-s to drive the plasma current. Plasma heating is accomplished by 12 neutral beam-injectors, which provide 60 MW. The energy transfer and storage system consists of a central superconducting storage ring, a homopolar energy storage unit, and a variety of inductor-converters.

  19. Sparsely Sampling the Sky: A Bayesian Experimental Design Approach

    CERN Document Server

    Paykari, P

    2012-01-01

    The next generation of galaxy surveys will observe millions of galaxies over large volumes of the universe. These surveys are expensive both in time and cost, raising questions regarding the optimal investment of this time and money. In this work we investigate criteria for selecting amongst observing strategies for constraining the galaxy power spectrum and a set of cosmological parameters. Depending on the parameters of interest, it may be more efficient to observe a larger, but sparsely sampled, area of sky instead of a smaller contiguous area. In this work, by making use of the principles of Bayesian Experimental Design, we will investigate the advantages and disadvantages of the sparse sampling of the sky and discuss the circumstances in which a sparse survey is indeed the most efficient strategy. For the Dark Energy Survey (DES), we find that by sparsely observing the same area in a smaller amount of time, we only increase the errors on the parameters by a maximum of 0.45%. Conversely, investing the sam...

  20. From CAD to Robot: Undergraduate Capstone Design in Engineering Technology

    Directory of Open Access Journals (Sweden)

    Kuldeep S. Rawat

    2013-06-01

    Full Text Available A novel senior project in designing and implementing a wheeled platform-based experimental mobile robot is discussed. This mobile robot design project was used as a platform to learn sensor interfacing, microcontroller programming, motor control, and electronic circuit design and troubleshooting. A specially designed proto board was used so that students could experiment with various types of sensors and supporting electronic circuitry. The modules implemented in this project are, servo motor control, infrared (IR-based obstacle detection and avoidance, temperature sensing, and IR wireless communication. An 8-bit Peripheral Interface Controller (PIC microcontroller, operating at 20MHz, was used as a programmable controller to monitor external environment through sensors and make appropriate decisions. PIC microcontroller was programmed using PICBasic PRO, a BASIC like high-level language. The implementation was divided into separate experiments, through which the students progressively completed the mobile robot. This progressive experimentation helped students develop their knowledge of interfacing, microcontroller programming, electronic control, circuit design, and troubleshooting in an incremental manner. The robot design experiments, sensor interfacing, electronic control, supporting circuitry, problems faced and troubleshooting during implementation are discussed in the paper.

  1. Research of design challenges and new technologies for floating LNG

    Science.gov (United States)

    Lee, Dong-Hyun; Ha, Mun-Keun; Kim, Soo-Young; Shin, Sung-Chul

    2014-06-01

    With the rate of worldwide LNG demand expected to grow faster than that of gas demand, most major oil companies are currently investing their resources to develop floating LNG-FLNG (i.e. LNG FSRU and LNG FPSO). The global Floating LNG (FLNG) market trend will be reviewed based on demand and supply chain relationships. Typical technical issues associated with FLNG design are categorized in terms of global performance evaluation. Although many proven technologies developed through LNG carrier and oil FPSO projects are available for FLNG design, we are still faced with several technical challenges to clear for successful FLNG projects. In this study, some of the challenges encountered during development of the floating LNG facility (i.e. LNG FPSO and FSRU) will be reviewed together with their investigated solution. At the same time, research of new LNG-related technologies such as combined containment system will be presented.

  2. Design of Onboard Instrument Based on Virtual Instrument Technology

    Institute of Scientific and Technical Information of China (English)

    TANG Baoping; ZHONG Yuanchang; QIU Jianwei

    2006-01-01

    After analyzing and comparing the traditional automobile instrument, the onboard instrument based on virtual instrument technology is designed in this paper. The PC/104 computer was employed as the core processing unit of the onboard instrument, and the several intelligent data acquisition nodes are set and connected by the CAN bus, through which the nodes can communicate with the core processing unit. The information of the vehicle's working condition can be displayed synthetically by adopting virtual instrument technology. When the working condition goes beyond its limit, the system can emit an alarm, record and storage the abnormal condition automatically, and suggest how to deal with the abnormity urgently. The development background and design idea of onboard information system were elaborated in the paper. The software, the hardware architecture and the principle of onboard information system were introduced in detail.

  3. Possibilities and Challenges designing low-carbon-energy technologies

    DEFF Research Database (Denmark)

    Bjarklev, Araceli

    Footprint, concepts and tools from Life Cycle Assessment, and relevant elements from eco-efficiency theoretical frameworks. Often systemic approaches tend to be driven by completely rational models. However, our main contribution is to consider a more holistic approach that also includes socio......Though there is broad consensus that one of the solutions to the current environmental challenge will be based on the use of low-carbon technologies, and even though there is a big potential to turn to a more sustainable design and innovation, there are several elements that need to be taken...... as a study object and discusses the question: What are the main possibilities and challenges when designing low-carbon illumination technologies? To answer this question, we use a systemic approach including environmental, economic, energy and political issues using relevant concepts from the Ecological...

  4. Bioreactor technology in marine microbiology: from design to future application.

    Science.gov (United States)

    Zhang, Yu; Arends, Jan B A; Van de Wiele, Tom; Boon, Nico

    2011-01-01

    Marine micro-organisms have been playing highly diverse roles over evolutionary time: they have defined the chemistry of the oceans and atmosphere. During the last decades, the bioreactors with novel designs have become an important tool to study marine microbiology and ecology in terms of: marine microorganism cultivation and deep-sea bioprocess characterization; unique bio-chemical product formation and intensification; marine waste treatment and clean energy generation. In this review we briefly summarize the current status of the bioreactor technology applied in marine microbiology and the critical parameters to take into account during the reactor design. Furthermore, when we look at the growing population, as well as, the pollution in the coastal areas of the world, it is urgent to find sustainable practices that beneficially stimulate both the economy and the natural environment. Here we outlook a few possibilities where innovative bioreactor technology can be applied to enhance energy generation and food production without harming the local marine ecosystem.

  5. Hybrid propulsion technology program. Volume 1: Conceptional design package

    Science.gov (United States)

    Jensen, Gordon E.; Holzman, Allen L.; Leisch, Steven O.; Keilbach, Joseph; Parsley, Randy; Humphrey, John

    1989-01-01

    A concept design study was performed to configure two sizes of hybrid boosters; one which duplicates the advanced shuttle rocket motor vacuum thrust time curve and a smaller, quarter thrust level booster. Two sizes of hybrid boosters were configured for either pump-fed or pressure-fed oxygen feed systems. Performance analyses show improved payload capability relative to a solid propellant booster. Size optimization and fuel safety considerations resulted in a 4.57 m (180 inch) diameter large booster with an inert hydrocarbon fuel. The preferred diameter for the quarter thrust level booster is 2.53 m (96 inches). As part of the design study critical technology issues were identified and a technology acquisition and demonstration plan was formulated.

  6. Research of design challenges and new technologies for floating LNG

    Directory of Open Access Journals (Sweden)

    Lee Dong-Hyun

    2014-06-01

    Full Text Available With the rate of worldwide LNG demand expected to grow faster than that of gas demand, most major oil companies are currently investing their resources to develop floating LNG-FLNG (i.e. LNG FSRU and LNG FPSO. The global Floating LNG (FLNG market trend will be reviewed based on demand and supply chain relationships. Typical technical issues associated with FLNG design are categorized in terms of global performance evaluation. Although many proven technologies developed through LNG carrier and oil FPSO projects are available for FLNG design, we are still faced with several technical challenges to clear for successful FLNG projects. In this study, some of the challenges encountered during development of the floating LNG facility (i.e. LNG FPSO and FSRU will be reviewed together with their investigated solution. At the same time, research of new LNG-related technologies such as combined containment system will be presented.

  7. [Experimental design and data handling in food microbiology].

    Science.gov (United States)

    Carbonell, E A

    1993-02-01

    A discussion on the problems associated with designing experiments in Food Microbiology research is presented. After defining what is meant by Design of an Experiment, a series of questions are raised that, once answered, will help in properly designing the experiment. It is emphasized the chain research-design-model-analysis-design and the danger in blindly using well-known designs and canned programs.

  8. Gender designs IT construction and deconstruction of information society technology

    CERN Document Server

    Zorn, Isabel; Rommes, Els; Schirmer, Carola; Schelhowe, Heidi

    2007-01-01

    How can information technology (IT) paradigms and design processes be studied from a gender perspective? What does IT design look like when its construction is informed by gender research? Though gender research and computing science seem like two separate worlds, this book proves how inspirational a confrontation and combination of those worlds can be.A deconstructive analysis of advanced fields of computing shows the multiple ways in which software design is gendered and how gendering effects are produced by its use. Concepts and assumptions underlying research and development, along with design tools and IT products, teaching methods and materials are studied.The book not only offers a gender analysis of information society technologies, it also shows practical examples of how IT can be different. A gender perspective on IT design can serve as an eye-opener for what tends to be overlooked and left out. It yields innovative ideas and high quality software systems that may empower a large diversity of user...

  9. A New Two-Step Approach for Hands-On Teaching of Gene Technology: Effects on Students' Activities During Experimentation in an Outreach Gene Technology Lab

    Science.gov (United States)

    Scharfenberg, Franz-Josef; Bogner, Franz X.

    2011-08-01

    Emphasis on improving higher level biology education continues. A new two-step approach to the experimental phases within an outreach gene technology lab, derived from cognitive load theory, is presented. We compared our approach using a quasi-experimental design with the conventional one-step mode. The difference consisted of additional focused discussions combined with students writing down their ideas (step one) prior to starting any experimental procedure (step two). We monitored students' activities during the experimental phases by continuously videotaping 20 work groups within each approach ( N = 131). Subsequent classification of students' activities yielded 10 categories (with well-fitting intra- and inter-observer scores with respect to reliability). Based on the students' individual time budgets, we evaluated students' roles during experimentation from their prevalent activities (by independently using two cluster analysis methods). Independently of the approach, two common clusters emerged, which we labeled as `all-rounders' and as `passive students', and two clusters specific to each approach: `observers' as well as `high-experimenters' were identified only within the one-step approach whereas under the two-step conditions `managers' and `scribes' were identified. Potential changes in group-leadership style during experimentation are discussed, and conclusions for optimizing science teaching are drawn.

  10. ULTRA HIGH SPEED FACTORIAL DESIGN IN SUB-NANOMETER TECHNOLOGY

    Directory of Open Access Journals (Sweden)

    Arindam Banerjee

    2013-02-01

    Full Text Available This work proposes a high speed and low power factorial design in 22nm technology and also it counts the effect of sub nano-meter constraints on this circuit. A comparative study for this design has been done for 90nm, 45nm and 22nm technology. The rise in circuit complexity and speed is accompanied by the scaling of MOSFET’s. The transistor saturation current Idsat is an important parameter because the transistor current determines the time needed to charge and discharge the capacitive loads on chip, and thus impacts the product speed more than any other transistor parameter. The efficient implementation of a factorial number is carried out by using a decremented and multipliers which has been lucidly discussed in this paper. Normally in a factorial module a number is calculated as the iterative multiplication of the given number to the decremented value of the given number. A Parallel adder based decremented has been proposed for calculating the factorial of any number that also includes 0 and 1. The performances are calculated by using the existing 90-nm CMOS technology and scaling down the existing technology to 45-nm and 22-nm.

  11. The Visual Web User Interface Design in Augmented Reality Technology

    Directory of Open Access Journals (Sweden)

    Chouyin Hsu

    2013-03-01

    Full Text Available Upon the popularity of 3C devices, the visual creatures are all around us, such the online game, touch pad, video and animation. Therefore, the text-based web page will no longer satisfy users. With the popularity of webcam, digital camera, stereoscopic glasses, or head-mounted display, the user interface becomes more visual and multi-dimensional. For the consideration of 3D and visual display in the research of web user interface design, Augmented Reality technology providing the convenient tools and impressive effects becomes the hot topic. Augmented Reality effect enables users to represent parts of the digital objects on top of the physical surroundings. The easy operation with webcam greatly improving the visual representation of web pages becomes the interest of our research. Therefore, we apply Augmented Reality technology for developing a city tour web site to collect the opinions of users. Therefore, the website stickiness is an important measurement. The major tasks of the work include the exploration of Augmented Reality technology and the evaluation of the outputs of Augmented Reality. The feedback opinions of users are valuable references for improving AR application in the work. As a result, the AR increasing the visual and interactive effects of web page encourages users to stay longer and more than 80% of users are willing to return for visiting the website soon. Moreover, several valuable conclusions about Augmented Reality technology in web user interface design are also provided for further practical references.

  12. Constructivism, Instructional Design, and Technology: Implications for Transforming Distance Learning

    Directory of Open Access Journals (Sweden)

    Maureen Tam

    2000-01-01

    Full Text Available This paper examines the characteristics and value of designed instruction grounded in the constructivist theory. It also attempts to connect the theory to the prevailing technology paradigms to establish an alignment between pedagogical and technological considerations in support of the assumptions arising from constructivism. Distance learning provides a unique context in which to infuse constructivist principles where learners are expected to function as self-motivated, self-directed, interactive, collaborative participants in their learning experiences by virtue of their physical location. Hence, the aim of this paper is to provide a clear link between the theoretical principles of constructivism, the construction of technology-supported learning environments, and the practice of distance education. The questions driving the argument in this paper include: What do constructivist perspectives offer instructional design and practice? What do computing technologies offer? And what do the two afford in combination? In particular, how do the two combine to transform distance learning from a highly industrialized mass production model to one that emphasizes subjective construction of knowledge and meaning derived from individual experiences.

  13. Exploring memory hierarchy design with emerging memory technologies

    CERN Document Server

    Sun, Guangyu

    2014-01-01

    This book equips readers with tools for computer architecture of high performance, low power, and high reliability memory hierarchy in computer systems based on emerging memory technologies, such as STTRAM, PCM, FBDRAM, etc.  The techniques described offer advantages of high density, near-zero static power, and immunity to soft errors, which have the potential of overcoming the “memory wall.”  The authors discuss memory design from various perspectives: emerging memory technologies are employed in the memory hierarchy with novel architecture modification;  hybrid memory structure is introduced to leverage advantages from multiple memory technologies; an analytical model named “Moguls” is introduced to explore quantitatively the optimization design of a memory hierarchy; finally, the vulnerability of the CMPs to radiation-based soft errors is improved by replacing different levels of on-chip memory with STT-RAMs.   ·         Provides a holistic study of using emerging memory technologies i...

  14. Experimental examinations of semiconductor laser amplifiers for optical communication technology

    Science.gov (United States)

    Ludwig, Reinhold

    1993-01-01

    Properties of SLA (Semiconductor Laser Amplifier), which are particularly interesting for application to linear repeaters in coherent multichannel systems, are studied and design rules for future optimized amplifier structure are deduced. Laser diode antireflection was examined and reflection factor was measured. Low signal properties were discussed considering injection current, wavelengths, temperature and polarization. The coupling between amplifiers and glass fibers was examined. The utilization of cascade amplifiers as linear repeaters in multichannel heterodyne systems and television distribution systems was investigatied. The following results are obtained: measurement and calculation of the paradiaphony between two signals radiated in a SLA; multichannel data transfer through a SLA; polarization independent amplification with SLA configurations; measurement of the frequency dependence of four wave mixing sidelines in a SLA; measurement of the system degradation through echoes in a bidirectional SLA chain; data transmission with frequency conversion and calculation of multichannel transmission systems with cascade SLA, taking into account saturation, signal to noise ratio, bandwidth reduction and echo.

  15. The Space House TM : Space Technologies in Architectural Design

    Science.gov (United States)

    Gampe, F.; Raitt, D.

    2002-01-01

    The word "space" has always been associated with and had a profound impact upon architectural design. Until relatively recently, however, the term has been used in a different sense to that understood by the aerospace community - for them, space was less abstract, more concrete and used in the context of space flight and space exploration, rather than, say, an empty area or space requiring to be filled by furniture. However, the two senses of the word space have now converged to some extent. Interior designers and architects have been involved in designing the interior of Skylab, the structure of the International Space Station, and futuristic space hotels. Today, architects are designing, and builders are building, houses, offices and other structures which incorporate a plethora of new technologies, materials and production processes in an effort not only to introduce innovative and adventurous ideas but also in an attempt to address environmental and social issues. Foremost among these new technologies and materials being considered today are those that have been developed for and by the space industry. This paper examines some of these space technologies, such as energy efficient solar cells, durable plastics, air and water filtration techniques, which have been adapted to both provide power while reducing energy consumption, conserve resources and so on. Several of these technologies have now been employed by the European Space Agency to develop a Space House TM - the first of its kind, which will be deployed not so much on planets like Mars, but rather here on Earth. The Space House TM, which exhibits many innovative features such as high strength light-weight carbon composites, active noise-damped, (glass and plastic) windows, low-cost solar arrays and latent heat storage, air and water purification systems will be described.

  16. Home Automation : Smart home technology and template house design

    OpenAIRE

    Zheng, Zeya

    2013-01-01

    In this thesis, home automation’s general knowledge, technology information and each component will be introduced to the reader in the first half of the whole thesis. In the second half, thesis includes the Home Automation template design and market competitiveness analysis. The author assumes that the reader is going to spend lots of money to have a smart home. In this situation, the author introduces the home automation to the reader at each component. So the reader in this thesis actu...

  17. Educational Technology Research Journals: "International Journal of Technology and Design Education", 2005-2014

    Science.gov (United States)

    Christensen, James M.; Jones, Brian; Cooper, Jessica Rose; McAllister, Laura; Ware, Mark B.; West, Richard E.

    2015-01-01

    This study examines the trends of the "International Journal of Technology and Design Education" over the past decade (2005-2014). The researchers looked at trends in article topics, research methods, authorship, and article citations by analyzing keyword frequencies, performing word counts of article titles, classifying studies…

  18. An efficient approach to bioconversion kinetic model generation based on automated microscale experimentation integrated with model driven experimental design

    DEFF Research Database (Denmark)

    Chen, B. H.; Micheletti, M.; Baganz, F.;

    2009-01-01

    design. It incorporates a model driven approach to the experimental design that minimises the number of experiments to be performed, while still generating accurate values of kinetic parameters. The approach has been illustrated with the transketolase mediated asymmetric synthesis of L...... experimental design.]it comparison with conventional methodology, the modelling approach enabled a nearly 4-fold decrease in the number of experiments while the microwell experimentation enabled a 45-fold decrease in material requirements and a significant increase in experimental throughput. The approach......Reliable models of enzyme kinetics are required for the effective design of bioconversion processes. Kinetic expressions of the enzyme-catalysed reaction rate however, are frequently complex and establishing accurate values of kinetic parameters normally requires a large number of experiments...

  19. Semantics and technologies in modern design of interior stairs

    Science.gov (United States)

    Kukhta, M.; Sokolov, A.; Pelevin, E.

    2015-10-01

    Use of metal in the design of interior stairs presents new features for shaping, and can be implemented using different technologies. The article discusses the features of design and production technologies of forged metal spiral staircase considering the image semantics based on the historical and cultural heritage. To achieve the objective was applied structural- semantic method (to identify the organization of structure and semantic features of the artistic image), engineering methods (to justify the construction of the object), anthropometry method and ergonomics (to provide usability), methods of comparative analysis (to reveale the features of the way the ladder in different periods of culture). According to the research results are as follows. Was revealed the semantics influence on the design of interior staircase that is based on the World Tree image. Also was suggested rational calculation of steps to ensure the required strength. And finally was presented technology, providing the realization of the artistic image. In the practical part of the work is presented version of forged staircase.

  20. Micro-Randomized Trials: An Experimental Design for Developing Just-in-Time Adaptive Interventions

    Science.gov (United States)

    Klasnja, Predrag; Hekler, Eric B.; Shiffman, Saul; Boruvka, Audrey; Almirall, Daniel; Tewari, Ambuj; Murphy, Susan A.

    2015-01-01

    Objective This paper presents an experimental design, the micro-randomized trial, developed to support optimization of just-in-time adaptive interventions (JITAIs). JITAIs are mHealth technologies that aim to deliver the right intervention components at the right times and locations to optimally support individuals’ health behaviors. Micro-randomized trials offer a way to optimize such interventions by enabling modeling of causal effects and time-varying effect moderation for individual intervention components within a JITAI. Methods The paper describes the micro-randomized trial design, enumerates research questions that this experimental design can help answer, and provides an overview of the data analyses that can be used to assess the causal effects of studied intervention components and investigate time-varying moderation of those effects. Results Micro-randomized trials enable causal modeling of proximal effects of the randomized intervention components and assessment of time-varying moderation of those effects. Conclusions Micro-randomized trials can help researchers understand whether their interventions are having intended effects, when and for whom they are effective, and what factors moderate the interventions’ effects, enabling creation of more effective JITAIs. PMID:26651463

  1. Experimental characterization and numerical modeling of PEMFC stacks designed for different application fields

    Energy Technology Data Exchange (ETDEWEB)

    Jannelli, E.; Minutillo, M. [University of Naples, Parthenope, Centro Direzionale, Naples (Italy); Perna, A. [University of Cassino, Cassino (Italy)

    2011-12-15

    Proton exchange membrane fuel cell (PEMFC) is regarded as a potential future power technology for stationary and mobile applications due to its high efficiency (full and partial load), rapid start-up, high power density, and low emissions. Depending on their particular application field (decentralized combined heat and power production, uninterrupted power supplies (UPS), or mobile applications) different operating conditions and designing parameters are required and different performance can be expected. Thus, the aim of this paper is to investigate the behavior and performance of two stacks of the same size, developed with a different approach according to their application sectors. The first PEMFC stack is designed for UPS units or mobile purpose, the second one, is designed to supply heat and power in residential applications (CHP units). The analysis of the stacks behavior has been carried out by using both experimental and numerical investigations. Experimental results have allowed: (i) to characterize the stacks; (ii) to calibrate the numerical model; (iii) to supply useful data for setting and improving the control system. (Copyright copyright 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  2. Experimental Design on Laminated Veneer Lumber Fiber Composite: Surface Enhancement

    Science.gov (United States)

    Meekum, U.; Mingmongkol, Y.

    2010-06-01

    Thick laminate veneer lumber(LVL) fibre reinforced composites were constructed from the alternated perpendicularly arrayed of peeled rubber woods. Glass woven was laid in between the layers. Native golden teak veneers were used as faces. In house formulae epoxy was employed as wood adhesive. The hand lay-up laminate was cured at 150° C for 45 mins. The cut specimen was post cured at 80° C for at least 5 hours. The 2k factorial design of experimental(DOE) was used to verify the parameters. Three parameters by mean of silane content in epoxy formulation(A), smoke treatment of rubber wood surface(B) and anti-termite application(C) on the wood surface were analysed. Both low and high levels were further subcategorised into 2 sub-levels. Flexural properties were the main respond obtained. ANOVA analysis of the Pareto chart was engaged. The main effect plot was also testified. The results showed that the interaction between silane quantity and termite treatment is negative effect at high level(AC+). Vice versa, the interaction between silane and smoke treatment was positive significant effect at high level(AB+). According to this research work, the optimal setting to improve the surface adhesion and hence flexural properties enhancement were high level of silane quantity, 15% by weight, high level of smoked wood layers, 8 out of 14 layers, and low anti termite applied wood. The further testes also revealed that the LVL composite had superior properties that the solid woods but slightly inferior in flexibility. The screw withdrawn strength of LVL showed the higher figure than solid wood. It is also better resistance to moisture and termite attack than the rubber wood.

  3. Optimization of model parameters and experimental designs with the Optimal Experimental Design Toolbox (v1.0) exemplified by sedimentation in salt marshes

    Science.gov (United States)

    Reimer, J.; Schuerch, M.; Slawig, T.

    2015-03-01

    The geosciences are a highly suitable field of application for optimizing model parameters and experimental designs especially because many data are collected. In this paper, the weighted least squares estimator for optimizing model parameters is presented together with its asymptotic properties. A popular approach to optimize experimental designs called local optimal experimental designs is described together with a lesser known approach which takes into account the potential nonlinearity of the model parameters. These two approaches have been combined with two methods to solve their underlying discrete optimization problem. All presented methods were implemented in an open-source MATLAB toolbox called the Optimal Experimental Design Toolbox whose structure and application is described. In numerical experiments, the model parameters and experimental design were optimized using this toolbox. Two existing models for sediment concentration in seawater and sediment accretion on salt marshes of different complexity served as an application example. The advantages and disadvantages of these approaches were compared based on these models. Thanks to optimized experimental designs, the parameters of these models could be determined very accurately with significantly fewer measurements compared to unoptimized experimental designs. The chosen optimization approach played a minor role for the accuracy; therefore, the approach with the least computational effort is recommended.

  4. Designing defect spins for wafer-scale quantum technologies

    Energy Technology Data Exchange (ETDEWEB)

    Koehl, William F. [Argonne National Lab. (ANL), Argonne, IL (United States); Univ. of Chicago, IL (United States); Seo, Hosung [Univ. of Chicago, IL (United States); Galli, Giulia [Argonne National Lab. (ANL), Argonne, IL (United States); Univ. of Chicago, IL (United States); Awschalom, David D. [Argonne National Lab. (ANL), Argonne, IL (United States); Univ. of Chicago, IL (United States)

    2015-11-27

    The past decade has seen remarkable progress in the development of the nitrogen-vacancy (NV) defect center in diamond, which is one of the leading candidates for quantum information technologies. The success of the NV center as a solid-state qubit has stimulated an active search for similar defect spins in other technologically important and mature semiconductors, such as silicon carbide. If successfully combined with the advanced microfabrication techniques available to such materials, coherent quantum control of defect spins could potentially lead to semiconductor-based, wafer-scale quantum technologies that make use of exotic quantum mechanical phenomena like entanglement. In this article, we describe the robust spin property of the NV center and the current status of NV center research for quantum information technologies. We then outline first-principles computational modeling techniques based on density functional theory to efficiently search for potential spin defects in nondiamond hosts suitable for quantum information applications. The combination of computational modeling and experimentation has proven invaluable in this area, and we describe the successful interplay between theory and experiment achieved with the divacancy spin qubit in silicon carbide.

  5. City Connects: Building an Argument for Effects on Student Achievement with a Quasi-Experimental Design

    Science.gov (United States)

    Walsh, Mary; Raczek, Anastasia; Sibley, Erin; Lee-St. John, Terrence; An, Chen; Akbayin, Bercem; Dearing, Eric; Foley, Claire

    2015-01-01

    While randomized experimental designs are the gold standard in education research concerned with causal inference, non-experimental designs are ubiquitous. For researchers who work with non-experimental data and are no less concerned for causal inference, the major problem is potential omitted variable bias. In this presentation, the authors…

  6. 14 CFR 437.85 - Allowable design changes; modification of an experimental permit.

    Science.gov (United States)

    2010-01-01

    ... Conditions of an Experimental Permit § 437.85 Allowable design changes; modification of an experimental... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Allowable design changes; modification of an experimental permit. 437.85 Section 437.85 Aeronautics and Space COMMERCIAL SPACE...

  7. Design & Realization of an Experimental Internet-based Information Retrieval Network System%因特网信息检索实验网络系统的设计与实现

    Institute of Scientific and Technical Information of China (English)

    黄晓梅; 沈祥兴

    2001-01-01

    Based on the authors' experiences in practice, this paper deals with the technology and scheme of designing and realizing the experimental Internet-Based Information Retrieval Network System. It mainly discusses its general design scheme and access to the Internet.

  8. Results-Based Organization Design for Technology Entrepreneurs

    Directory of Open Access Journals (Sweden)

    Chris McPhee

    2012-05-01

    Full Text Available Faced with considerable uncertainty, entrepreneurs would benefit from clearly defined objectives, a plan to achieve these objectives (including a reasonable expectation that this plan will work, as well as a means to measure progress and make requisite course corrections. In this article, the author combines the benefits of results-based management with the benefits of organization design to describe a practical approach that technology entrepreneurs can use to design their organizations so that they deliver desired outcomes. This approach links insights from theory and practice, builds logical connections between entrepreneurial activities and desired outcomes, and measures progress toward those outcomes. This approach also provides a mechanism for entrepreneurs to make continual adjustments and improvements to their design and direction in response to data, customer and stakeholder feedback, and changes in their business environment.

  9. Low power RF circuit design in standard CMOS technology

    CERN Document Server

    Alvarado, Unai; Adín, Iñigo

    2012-01-01

    Low Power Consumption is one of the critical issues in the performance of small battery-powered handheld devices. Mobile terminals feature an ever increasing number of wireless communication alternatives including GPS, Bluetooth, GSM, 3G, WiFi or DVB-H. Considering that the total power available for each terminal is limited by the relatively slow increase in battery performance expected in the near future, the need for efficient circuits is now critical. This book presents the basic techniques available to design low power RF CMOS analogue circuits. It gives circuit designers a complete guide of alternatives to optimize power consumption and explains the application of these rules in the most common RF building blocks: LNA, mixers and PLLs. It is set out using practical examples and offers a unique perspective as it targets designers working within the standard CMOS process and all the limitations inherent in these technologies.

  10. 2nd Topical Workshop on Laser Technology and Optics Design

    CERN Document Server

    2013-01-01

    Lasers have a variety of applications in particle accelerator operation and will play a key role in the development of future particle accelerators by improving the generation of high brightness electron and exotic ion beams and through increasing the acceleration gradient. Lasers will also make an increasingly important contribution to the characterization of many complex particle beams by means of laser-based beam diagnostics methods. The second LANET topical workshop will address the key aspects of laser technology and optics design relevant to laser application to accelerators. The workshop will cover general optics design, provide an overview of different laser sources and discuss methods to characterize beams in details. Participants will be able to choose from a range of topical areas that go deeper in more specific aspects including tuneable lasers, design of transfer lines, noise sources and their elimination and non-linear optics effects. The format of the workshop will be mainly training-based wit...

  11. Quantifying Astronaut Tasks: Robotic Technology and Future Space Suit Design

    Science.gov (United States)

    Newman, Dava

    2003-01-01

    The primary aim of this research effort was to advance the current understanding of astronauts' capabilities and limitations in space-suited EVA by developing models of the constitutive and compatibility relations of a space suit, based on experimental data gained from human test subjects as well as a 12 degree-of-freedom human-sized robot, and utilizing these fundamental relations to estimate a human factors performance metric for space suited EVA work. The three specific objectives are to: 1) Compile a detailed database of torques required to bend the joints of a space suit, using realistic, multi- joint human motions. 2) Develop a mathematical model of the constitutive relations between space suit joint torques and joint angular positions, based on experimental data and compare other investigators' physics-based models to experimental data. 3) Estimate the work envelope of a space suited astronaut, using the constitutive and compatibility relations of the space suit. The body of work that makes up this report includes experimentation, empirical and physics-based modeling, and model applications. A detailed space suit joint torque-angle database was compiled with a novel experimental approach that used space-suited human test subjects to generate realistic, multi-joint motions and an instrumented robot to measure the torques required to accomplish these motions in a space suit. Based on the experimental data, a mathematical model is developed to predict joint torque from the joint angle history. Two physics-based models of pressurized fabric cylinder bending are compared to experimental data, yielding design insights. The mathematical model is applied to EVA operations in an inverse kinematic analysis coupled to the space suit model to calculate the volume in which space-suited astronauts can work with their hands, demonstrating that operational human factors metrics can be predicted from fundamental space suit information.

  12. Secure, Mobile, Wireless Network Technology Designed, Developed, and Demonstrated

    Science.gov (United States)

    Ivancic, William D.; Paulsen, Phillip E.

    2004-01-01

    The inability to seamlessly disseminate data securely over a high-integrity, wireless broadband network has been identified as a primary technical barrier to providing an order-of-magnitude increase in aviation capacity and safety. Secure, autonomous communications to and from aircraft will enable advanced, automated, data-intensive air traffic management concepts, increase National Air Space (NAS) capacity, and potentially reduce the overall cost of air travel operations. For the first time ever, secure, mobile, network technology was designed, developed, and demonstrated with state-ofthe- art protocols and applications by a diverse, cooperative Government-industry team led by the NASA Glenn Research Center. This revolutionary technology solution will make fundamentally new airplane system capabilities possible by enabling secure, seamless network connections from platforms in motion (e.g., cars, ships, aircraft, and satellites) to existing terrestrial systems without the need for manual reconfiguration. Called Mobile Router, the new technology autonomously connects and configures networks as they traverse from one operating theater to another. The Mobile Router demonstration aboard the Neah Bay, a U.S. Coast Guard vessel stationed in Cleveland, Ohio, accomplished secure, seamless interoperability of mobile network systems across multiple domains without manual system reconfiguration. The Neah Bay was chosen because of its low cost and communications mission similarity to low-Earth-orbiting satellite platforms. This technology was successfully advanced from technology readiness level (TRL) 2 (concept and/or application formation) to TRL 6 (system model or prototype demonstration in a relevant environment). The secure, seamless interoperability offered by the Mobile Router and encryption device will enable several new, vehicle-specific and systemwide technologies to perform such things as remote, autonomous aircraft performance monitoring and early detection and

  13. Ergonomic design in the operating room: information technologies

    Science.gov (United States)

    Morita, Mark M.; Ratib, Osman

    2005-04-01

    The ergonomic design in the Surgical OR of information technology systems has been and continues to be a large problem. Numerous disparate information systems with unique hardware and display configurations create an environment similar to the chaotic environments of air traffic control. Patient information systems tend to show all available statistics making it difficult to isolate the key, relevant vitals for the patient. Interactions in this sterile environment are still being done with the traditional keyboard and mouse designed for cubicle office workflows. This presentation will address the shortcomings of the current design paradigm in the Surgical OR that relate to Information Technology systems. It will offer a perspective that addresses the ergonomic deficiencies and predicts how future technological innovations will integrate into this vision. Part of this vision includes a Surgical OR PACS prototype, developed by GE Healthcare Technologies, that addresses ergonomic challenges of PACS in the OR that include lack of portability, sterile field integrity, and UI targeted for diagnostic radiologists. GWindows (gesture control) developed by Microsoft Research and Voice command will allow for the surgeons to navigate and review diagnostic imagery without using the conventional keyboard and mouse that disrupt the integrity of the sterile field. This prototype also demonstrates how a wireless, battery powered, self contained mobile PACS workstation can be optimally positioned for a surgeon to reference images during an intervention as opposed to the current pre-operative review. Lessons learned from the creation of the Surgical OR PACS Prototype have demonstrated that PACS alone is not the end all solution in the OR. Integration of other disparate information systems and presentation of this information in simple, easy to navigate information packets will enable smoother interactions for the surgeons and other healthcare professionals in the OR. More intuitive

  14. Artificial Warming of Arctic Meadow under Pollution Stress: Experimental design

    Science.gov (United States)

    Moni, Christophe; Silvennoinen, Hanna; Fjelldal, Erling; Brenden, Marius; Kimball, Bruce; Rasse, Daniel

    2014-05-01

    Boreal and arctic terrestrial ecosystems are central to the climate change debate, notably because future warming is expected to be disproportionate as compared to world averages. Likewise, greenhouse gas (GHG) release from terrestrial ecosystems exposed to climate warming is expected to be the largest in the arctic. Artic agriculture, in the form of cultivated grasslands, is a unique and economically relevant feature of Northern Norway (e.g. Finnmark Province). In Eastern Finnmark, these agro-ecosystems are under the additional stressor of heavy metal and sulfur pollution generated by metal smelters of NW Russia. Warming and its interaction with heavy metal dynamics will influence meadow productivity, species composition and GHG emissions, as mediated by responses of soil microbial communities. Adaptation and mitigation measurements will be needed. Biochar application, which immobilizes heavy metal, is a promising adaptation method to promote positive growth response in arctic meadows exposed to a warming climate. In the MeadoWarm project we conduct an ecosystem warming experiment combined to biochar adaptation treatments in the heavy-metal polluted meadows of Eastern Finnmark. In summary, the general objective of this study is twofold: 1) to determine the response of arctic agricultural ecosystems under environmental stress to increased temperatures, both in terms of plant growth, soil organisms and GHG emissions, and 2) to determine if biochar application can serve as a positive adaptation (plant growth) and mitigation (GHG emission) strategy for these ecosystems under warming conditions. Here, we present the experimental site and the designed open-field warming facility. The selected site is an arctic meadow located at the Svanhovd Research station less than 10km west from the Russian mining city of Nikel. A splitplot design with 5 replicates for each treatment is used to test the effect of biochar amendment and a 3oC warming on the Arctic meadow. Ten circular

  15. Creative Design: An Integral Aspect of Innovation in Industrial Design and Technology

    Directory of Open Access Journals (Sweden)

    Yohanna ogbu Egiri

    2015-06-01

    Full Text Available Design and Innovation is a twin words which are most discussed when it comes to creativity in highly competitive markets. Nevertheless, the specific contribution of design and designers in the context of product innovation is insufficiently understood and explored. Mostly, innovation is meant to be the achievement of science and technology, while design as the last element in this chain has the task to introduce the scientific and technological innovation into the life-world of the user. The list of needs include hidden needs, needs that customers may not be aware of or problems they simply accept without question, as well as explicit needs, or needs that will most likely be reported by potential purchasers. Researchers develop the necessary information on which to base the performance, size, weight, service life, and other specifications of the product. Customer needs and product specifications are organized into a hierarchical list with a comparative rating value given to each need and specification. Keywords: Design, Innovation, Technology, Creative design, Product innovation, Customer.

  16. Advanced Technology Subsonic Transport Study: N+3 Technologies and Design Concepts

    Science.gov (United States)

    Raymer, Daniel P.; Wilson, Jack; Perkins, H. Douglas; Rizzi, Arthur; Zhang, Mengmeng; RamirezPuentes, Alfredo

    2011-01-01

    Conceptual Research Corporation, the Science of the Possible, has completed a two-year study of concepts and technologies for future airliners in the 180-passenger class. This NASA-funded contract was primarily focused on the ambitious goal of a 70 percent reduction in fuel consumption versus the market-dominating Boeing 737-800. The study is related to the N+3 contracts awarded in 2008 by NASA s Aeronautics Research Mission Directorate to teams led by Boeing, GE Aviation, MIT, and Northrop Grumman, but with more modest goals and funding. CRC s contract featured a predominant emphasis on propulsion and fuel consumption, but since fuel consumption depends upon air vehicle design as much as on propulsion technology, the study included notional vehicle design, analysis, and parametric studies. Other NASA goals including NOx and noise reduction are of long-standing interest but were not highlighted in this study, other than their inclusion in the propulsion system provided to CRC by NASA. The B-737-800 was used as a benchmark, parametric tool, and design point of departure. It was modeled in the RDS-Professional aircraft design software then subjected to extensive parametric variations of parasitic drag, drag-due-to-lift, specific fuel consumption, and unsized empty weight. These studies indicated that the goal of a 70 percent reduction in fuel consumption could be attained with roughly a 30 percent improvement in all four parameters. The results were then fit to a Response Surface and coded for ease of use in subsequent trade studies. Potential technologies to obtain such savings were identified and discussed. More than 16 advanced concept designs were then prepared, attempting to investigate almost every possible emerging concept for application to this class airliner. A preliminary assessment of these concepts was done based on their total wetted area after design normalization of trimmed maximum lift. This assessment points towards a Tailless Airliner concept which

  17. Design and experimental investigation of an oxy-fuel combustion system for magnetohydrodynamic power extraction

    Science.gov (United States)

    Hernandez, Manuel Johannes

    A general consensus in the scientific and research community is the need to restrict carbon emissions in energy systems. Therefore, extensive research efforts are underway to develop the next generation of energy systems. In the field of power generation, researchers are actively investigating novel methods to produce electricity in a cleaner, efficient form. Recently, Oxy-Combustion for magnetohydrodynamic power extraction has generated significant interest, since the idea was proposed as a method for clean power generation in coal and natural gas power plants. Oxy-combustion technologies have been proposed to provide high enthalpy, electrically conductive flows for direct conversion of electricity. Direct power extraction via magnetohydrodynamics (MHD) can occur as a consequence of the motion of "seeded" combustion products in the presence of magnetic fields. However, oxy-combustion technologies for MHD power extraction has not been demonstrated in the available literature. Furthermore, there are still fundamental unexplored questions remaining, associated with this technology, for MHD power extraction. In this present study, previous magnetohydrodynamic combustion technologies and technical issues in this field were assessed to develop a new combustion system for electrically conductive flows. The research aims were to fully understand the current-state-of-the-art of open-cycle magnetohydrodynamic technologies and present new future directions and concepts. The design criteria, methodology, and technical specifications of an advanced cooled oxy-combustion technology are presented in this dissertation. The design was based on a combined analytical, empirical, and numerical approach. Analytical one-dimensional (1D) design tools initiated design construction. Design variants were analyzed and vetted against performance criteria through the application of computational fluid dynamics modeling. CFD-generated flow fields permitted insightful visualization of the

  18. Designing for Designing: Information and Communication Technologies (ICTs) and Professional Education

    Science.gov (United States)

    Wang, Tsungjuang

    2011-01-01

    Information and Communication Technologies (ICTs) appear to be well fitted to the education of design professionals, such as architectural and engineering students, mainly because of the unique culture of these professional schools, where the emphasis is on creativity, collaboration, social relevance and rapid communication of ideas. Attention is…

  19. Synthesis of designed materials by laser-based direct metal deposition technique: Experimental and theoretical approaches

    Science.gov (United States)

    Qi, Huan

    Direct metal deposition (DMD), a laser-cladding based solid freeform fabrication technique, is capable of depositing multiple materials at desired composition which makes this technique a flexible method to fabricate heterogeneous components or functionally-graded structures. The inherently rapid cooling rate associated with the laser cladding process enables extended solid solubility in nonequilibrium phases, offering the possibility of tailoring new materials with advanced properties. This technical advantage opens the area of synthesizing a new class of materials designed by topology optimization method which have performance-based material properties. For better understanding of the fundamental phenomena occurring in multi-material laser cladding with coaxial powder injection, a self-consistent 3-D transient model was developed. Physical phenomena including laser-powder interaction, heat transfer, melting, solidification, mass addition, liquid metal flow, and species transportation were modeled and solved with a controlled-volume finite difference method. Level-set method was used to track the evolution of liquid free surface. The distribution of species concentration in cladding layer was obtained using a nonequilibrium partition coefficient model. Simulation results were compared with experimental observations and found to be reasonably matched. Multi-phase material microstructures which have negative coefficients of thermal expansion were studied for their DMD manufacturability. The pixel-based topology-optimal designs are boundary-smoothed by Bezier functions to facilitate toolpath design. It is found that the inevitable diffusion interface between different material-phases degrades the negative thermal expansion property of the whole microstructure. A new design method is proposed for DMD manufacturing. Experimental approaches include identification of laser beam characteristics during different laser-powder-substrate interaction conditions, an

  20. Design of a Combined Ballistic Simulator and Primer Force Experimental Fixture

    Science.gov (United States)

    2015-08-01

    ARL-MR-0896 ●AUG 2015 US Army Research Laboratory Design of a Combined Ballistic Simulator and Primer Force Experimental Fixture...SUBTITLE Design of a Combined Ballistic Simulator and Primer Force Experimental Fixture 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT...Contents List of Figures iv Acknowledgments v 1. Introduction 1 2. Background 1 3. Technical Approach 4 3.1 Hardware Design 4 3.2 Experimental Setup

  1. Supersonic Retro-Propulsion Experimental Design for Computational Fluid Dynamics Model Validation

    Science.gov (United States)

    Berry, Scott A.; Laws, Christopher T.; Kleb, W. L.; Rhode, Matthew N.; Spells, Courtney; McCrea, Andrew C.; Truble, Kerry A.; Schauerhamer, Daniel G.; Oberkampf, William L.

    2011-01-01

    The development of supersonic retro-propulsion, an enabling technology for heavy payload exploration missions to Mars, is the primary focus for the present paper. A new experimental model, intended to provide computational fluid dynamics model validation data, was recently designed for the Langley Research Center Unitary Plan Wind Tunnel Test Section 2. Pre-test computations were instrumental for sizing and refining the model, over the Mach number range of 2.4 to 4.6, such that tunnel blockage and internal flow separation issues would be minimized. A 5-in diameter 70-deg sphere-cone forebody, which accommodates up to four 4:1 area ratio nozzles, followed by a 10-in long cylindrical aftbody was developed for this study based on the computational results. The model was designed to allow for a large number of surface pressure measurements on the forebody and aftbody. Supplemental data included high-speed Schlieren video and internal pressures and temperatures. The run matrix was developed to allow for the quantification of various sources of experimental uncertainty, such as random errors due to run-to-run variations and bias errors due to flow field or model misalignments. Some preliminary results and observations from the test are presented, although detailed analyses of the data and uncertainties are still on going.

  2. Efficient Experimental Design Strategies in Toxicology and Bioassay

    Directory of Open Access Journals (Sweden)

    Timothy E. O'Brien

    2016-06-01

    Full Text Available Modelling in bioassay often uses linear or nonlinear logistic regression models, and relative potency is often the focus when two or more compounds are to be compared.  Estimation in these settings is typically based on likelihood methods.  Here, we focus on the 3-parameter model representation given in Finney (1978 in which the relative potency is a model parameter.  Using key matrix results and the general equivalence theorem of Kiefer & Wolfowitz (1960, this paper establishes key design properties of the optimal design for relative potency using this model.  We also highlight aspects of subset designs for the relative potency parameter and extend geometric designs to efficient design settings of bioassay.  These latter designs are thus useful for both parameter estimation and checking for goodness-of-fit.  A typical yet insightful example is provided from the field of toxicology to illustrate our findings.

  3. Deployment of RFID in healthcare facilities-experimental design in MRI department.

    Science.gov (United States)

    Cheng, Chen-Yang; Chai, Jyh-Wen

    2012-12-01

    Patient safety has become an important issue due to medical errors. Some health care systems use Radio Frequency Identification (RFID) to identify patients during medical procedures. However, the RFID data readability especially depends upon the environment, an investigation of data reliability and signal loss is essential to making an effective deployment plan. The operation of Magnetic Resonance Imaging (MRI) is the major source of electromagnetic interference in the hospital. Therefore, this research conducts an experimental design of reading performance considering various notable factors in the MRI department. In addition to the readability experiment, this paper also measures the efficiency and reliability of implementing RFID technology in the MRI department using a simulation approach and helps hospitals by providing the measured outcomes.

  4. Experimental Design and Bioinformatics Analysis for the Application of Metagenomics in Environmental Sciences and Biotechnology.

    Science.gov (United States)

    Ju, Feng; Zhang, Tong

    2015-11-01

    Recent advances in DNA sequencing technologies have prompted the widespread application of metagenomics for the investigation of novel bioresources (e.g., industrial enzymes and bioactive molecules) and unknown biohazards (e.g., pathogens and antibiotic resistance genes) in natural and engineered microbial systems across multiple disciplines. This review discusses the rigorous experimental design and sample preparation in the context of applying metagenomics in environmental sciences and biotechnology. Moreover, this review summarizes the principles, methodologies, and state-of-the-art bioinformatics procedures, tools and database resources for metagenomics applications and discusses two popular strategies (analysis of unassembled reads versus assembled contigs/draft genomes) for quantitative or qualitative insights of microbial community structure and functions. Overall, this review aims to facilitate more extensive application of metagenomics in the investigation of uncultured microorganisms, novel enzymes, microbe-environment interactions, and biohazards in biotechnological applications where microbial communities are engineered for bioenergy production, wastewater treatment, and bioremediation.

  5. Factorial experimental design of winery wastewaters treatment by heterogeneous photo-Fenton process.

    Science.gov (United States)

    Mosteo, Rosa; Ormad, Peña; Mozas, Engracia; Sarasa, Judith; Ovelleiro, José Luis

    2006-05-01

    Winery wastewaters are difficult to treat by conventional biological processes because they are seasonal and experience a substantial flow variations. Photocatalytic advanced oxidation is a promising technology for wastewaters containing high amounts of organic matter. In this work, the photo-Fenton process in heterogeneous phase is presented as an alternative methodology for the treatment of winery wastewaters. As a consequence of the great number of existing variables, an experimental design methodology has been used in order to study the influence and interaction of various variables and to obtain a reduced empirical model which describes the organic matter degradation process. Applying photo-Fenton treatment in heterogeneous phase under energetic conditions for synthetic samples simulating winery wastewaters results in purification levels of up to 50% (measured as total organic carbon). Different reduced models are obtained and their utilization depends mainly on the degree of degradation of organic matter required.

  6. AVID - A design system for technology studies of advanced transportation concepts. [Aerospace Vehicle Interactive Design

    Science.gov (United States)

    Wilhite, A. W.; Rehder, J. J.

    1979-01-01

    The basic AVID (Aerospace Vehicle Interactive Design) is a general system for conceptual and preliminary design currently being applied to a broad range of future space transportation and spacecraft vehicle concepts. AVID hardware includes a minicomputer allowing rapid designer interaction. AVID software includes (1) an executive program and communication data base which provide the automated capability to couple individual programs, either individually in an interactive mode or chained together in an automatic sequence mode; and (2) the individual technology and utility programs which provide analysis capability in areas such as graphics, aerodynamics, propulsion, flight performance, weights, sizing, and costs.

  7. Integrated systems, design and technology 2010 knowledge transfer in new technologies

    CERN Document Server

    Fathi, Madjid

    2011-01-01

    Knowledge creation and technological experiences resulting from modern production life cycles are definitely the most Economical and important intellectual capitals in the current manufacturing endeavors. These are also the basis for enabling industrial competition through managing and identifying organizational and product related needs and opportunities; e. g. health care systems society needs clean environment, sustainable production life cycles needs flexible approachable design and engineering of materials whilst valuable materials are needed for renewable energies and the production of

  8. Innovative experimental particle physics through technological advances: Past, present and future

    Energy Technology Data Exchange (ETDEWEB)

    Cheung, Harry W.K.; /Fermilab

    2005-01-01

    This mini-course gives an introduction to the techniques used in experimental particle physics with an emphasis on the impact of technological advances. The basic detector types and particle accelerator facilities will be briefly covered with examples of their use and with comparisons. The mini-course ends with what can be expected in the near future from current technology advances. The mini-course is intended for graduate students and post-docs and as an introduction to experimental techniques for theorists.

  9. Industry Standards for Technological Design and Construction Drawing Design of Rubber Factories Carried Out on August 1

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    On May 18, Ministry of Industry and Information Technology approved 2 industry standards of Rules of Technological Design Technology of Rubber Factories(HG/T 21558-2011) and Rules of Rubber Factories Construction Drawing Design Document Content and Depth (HG/T 21511-2011), which are to be carried out on August 1.

  10. 77 FR 43131 - Designation of the Center for Innovation and Technology Cooperation (CITC), Pentane Chemistry...

    Science.gov (United States)

    2012-07-23

    ... Designation of the Center for Innovation and Technology Cooperation (CITC), Pentane Chemistry Industries (PCI... of the Center for Innovation and Technology Cooperation (CITC), Pentane Chemistry Industries (PCI... determined that the Center for Innovation and Technology Cooperation (CITC), Pentane Chemistry Industries...

  11. Virtual Welded - Joint Design Integrating Advanced Materials and Processing Technology

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Zhishang; Ludewig, Howard W.; Babu, S. Suresh

    2005-06-30

    Virtual Welede-Joint Design, a systematic modeling approach, has been developed in this project to predict the relationship of welding process, microstructure, properties, residual stress, and the ultimate weld fatique strength. This systematic modeling approach was applied in the welding of high strength steel. A special welding wire was developed in this project to introduce compressive residual stress at weld toe. The results from both modeling and experiments demonstrated that more than 10x fatique life improvement can be acheived in high strength steel welds by the combination of compressive residual stress from the special welding wire and the desired weld bead shape from a unique welding process. The results indicate a technology breakthrough in the design of lightweight and high fatique performance welded structures using high strength steels.

  12. Birthplace of Fashion Designers: Beijing Institute of Clothing Technology

    Institute of Scientific and Technical Information of China (English)

    1995-01-01

    CLOTHING, as the old Chinese saying goes, is regarded as the most basic human need. In 1988 in Beijing, the first institute of higher learning to focus on the design and manufacture of clothing was established. The Beijing Institute of Clothing Technology (BICT) offers a combined curriculum of art and fashion that has fostered the talent of many outstanding young designers. The college is located near the ruins of the city wall from the Yuan Dynasty (1271-1368) and has an enrollment of 2,500 undergraduate and graduate students. Before 1988 the building housed a college of chemical fibre engineering that had many lecturers and professors who where considered accomplished at both theory and application. The school was expanded with the addition of nine subjects and three new departments—Garment,

  13. Use of Experimental Design for Peuhl Cheese Process Optimization ...

    African Journals Online (AJOL)

    Devika

    added (7 mL), heating temperature (84.12°C) and heating time (15 min). When these optimal ... conditions constitute one of the major obstacles for ... a two levels factorial design;. • a design of ... balance (Sartorius Gmbh, Göttingen, Germany),.

  14. Design of Experimental Displacement Digester Systems%置换蒸煮实验装置的设计

    Institute of Scientific and Technical Information of China (English)

    高致富; 侯顺利; 张锋; 杨海燕

    2013-01-01

    介绍了所设计的置换蒸煮实验装置的基本原理、系统构成及特点,本设计解决了以往置换蒸煮实验装置易堵塞、加热不均匀、取样难等问题.%In order to optimizing the technology of Displacement Digester System and realizing the domestication of the system,a simple scientific experimental device was developed.The technology process of Displacement Digester System is used in the laboratory experiment device.The parameters of the key parts of the digester were selected and calculated,then its structure was designed.The problems normally appeared in experimental Displacement Digester System device,including easily jamming,unevenly heating and difficultly sampling were solved in the experimental device developed by the authors with simple structure,lower cost and lower power consumption.This experimental device of Displacement Digester System can provide reliable experimental data for promoting the domestication of this technology.

  15. Experimental facility for development of high-temperature reactor technology: instrumentation needs and challenges

    Directory of Open Access Journals (Sweden)

    Sabharwall Piyush

    2015-01-01

    Full Text Available A high-temperature, multi-fluid, multi-loop test facility is under development at the Idaho National Laboratory for support of thermal hydraulic materials, and system integration research for high-temperature reactors. The experimental facility includes a high-temperature helium loop, a liquid salt loop, and a hot water/steam loop. The three loops will be thermally coupled through an intermediate heat exchanger (IHX and a secondary heat exchanger (SHX. Research topics to be addressed include the characterization and performance evaluation of candidate compact heat exchangers such as printed circuit heat exchangers (PCHEs at prototypical operating conditions. Each loop will also include an interchangeable high-temperature test section that can be customized to address specific research issues associated with each working fluid. This paper also discusses needs and challenges associated with advanced instrumentation for the multi-loop facility, which could be further applied to advanced high-temperature reactors. Based on its relevance to advanced reactor systems, the new facility has been named the Advanced Reactor Technology Integral System Test (ARTIST facility. A preliminary design configuration of the ARTIST facility will be presented with the required design and operating characteristics of the various components. The initial configuration will include a high-temperature (750 °C, high-pressure (7 MPa helium loop thermally integrated with a molten fluoride salt (KF-ZrF4 flow loop operating at low pressure (0.2 MPa, at a temperature of ∼450 °C. The salt loop will be thermally integrated with the steam/water loop operating at PWR conditions. Experiment design challenges include identifying suitable materials and components that will withstand the required loop operating conditions. The instrumentation needs to be highly accurate (negligible drift in measuring operational data for extended periods of times, as data collected will be

  16. 4D Design and Simulation Technologies and Process Design Patterns to Support Lean Construction Methods

    Institute of Scientific and Technical Information of China (English)

    Manfred Breit; Manfred Vogel; Fritz H(a)ubi; Fabian M(a)rki; Micheal Raps

    2008-01-01

    The objective of this ongoing joint research program is to determine how 3D/4D modeling, simula- tion and visualization of Products (buildings), Organizations and Processes (POP) can support lean con- struction. Initial findings suggest that Process Design Pattern may have the potential to intuitively support ICT based lean construction. We initiated a "Process Archeology" in order to reveal the requirements for tools that can support the planning, simulation and control of lean construction methods. First findings show that existing tools provide only limited support and therefore, we started to develop new methodologies and technologies to overcome these shortcomings. Through the introduction of Process Design Patterns, we in- tent to establish process thinking in the interdisciplinary POP design. Optimized construction processes may be synthesized with semi-automatic methods by applying Process Design Pattems on building structures. By providing process templates that integrate problem solution and expert knowledge, Process Design Pat- tems may have the potential to ensure high quality process models.

  17. Grappling with teaching design and technology: a beginning teacher's experiences

    Science.gov (United States)

    Stein, Sarah J.; Ginns, Ian S.; McRobbie, Campbell J.

    2003-02-01

    This paper reports on an investigation into the first time implementation of a technology education unit of work by a beginning primary school teacher. The researchers monitored the teacher's implementation of the unit across a 6 week period using an interpretivist research approach. A variety of data sources were drawn upon including teacher and student interviews, video and audio recordings of small group and whole-class interactions, and student-developed artefacts. Providing appropriate learning activities to assist students to develop understanding about patterns and shapes incorporated into buildings and other structures to enhance strength and stability was a challenge faced by the beginning teacher. However, she drew support from a teaching resource, which provided guidance and structure for the teaching of technology concepts and processes related to strength and stability of structures and materials. The resource helped her to develop learning activities that were appropriate to the topic and to the needs of the students in her class. Implications of the study relate to the needs of teachers grappling with teaching design and technology for the first time and the support that they can gain from predetermined planning and teaching models and well-developed teaching resources.

  18. Experimental validation of micro endmill design for hard milling application

    NARCIS (Netherlands)

    Li, P.; Hoogstrate, A.M.; Oosterling, J.A.J.; Langen, H.H.; Munnig Schmidt, R.

    2008-01-01

    Abstract: In experimental investigations of micro milling of hardened tool steel SAE H11, with a hardness of 56 HRC, with commercially available micro square endmills of Ø 0.5mm, it was observed that the endmills suffered from severe tool wear/failure. Because of these problems, the quality of the m

  19. Gunnar Aagaard Andersen: Commercial Design and Experimental Art

    DEFF Research Database (Denmark)

    Gether, Vibeke Petersen

    2016-01-01

    in Copenhagen and the magazine Mobilia. These enterprises were pioneers within both the commercial–industrial creative field and experimental art from the 1950s. The industrial process, from idea and experiment to production,as well as the expanded field of visual art, was demonstrated in concrete painting...

  20. New postage stamp design with tone gradation in Infraredesign technology

    Directory of Open Access Journals (Sweden)

    Maja Rudolf

    2013-01-01

    Full Text Available This paper deals with the application of new steganographic methods in postage stamp printing technology with the goal of securing them against counterfeiting. Postage stamp designs are presented which contain double information in the visible and in the infrared spectrum area. New methods include printing with process printing inks that have a continuous response in the infrared area of the spectrum. The infrared Z image cannot be produced with conventional CMYK separation in such a way that the hidden picture does not show through when looking at the print. This is the reason for introducing CMYKIR separation, with mathematical relations that respect printing ink characteristics in the RGB to CMYKIR system conversion.A mathematical model with targeted separation characteristics is proposed, with seven independent variables. It has been created as the result of optimal regression model developed on the basis of colour tone measuring for the visual and infrared spectrum. A technological procedure has been elaborated for producing and printing based on such designs. It is possible to detect the infrared image with the help of a device – the infrared ZRGB camera. Counterfeiting is impossible due to the irreversible conversion of the CMYKIR separation into the RGB system applied in contemporary scanners or cameras.

  1. Experimental design for research on shock-turbulence interaction

    Science.gov (United States)

    Radcliffe, S. W.

    1969-01-01

    Report investigates the production of acoustic waves in the interaction of a supersonic shock and a turbulence environment. The five stages of the investigation are apparatus design, development of instrumentation, preliminary experiment, turbulence generator selection, and main experiments.

  2. Experimental techniques for design of impact-resistant material (poster)

    NARCIS (Netherlands)

    Fan, J.; Weerheijm, J.; Sluys, L.J.

    2013-01-01

    Some polymers are not only transparent and lightweight, but also impact and ballistic resistant. Designing and preparing such polymeric materials with a high impact‐resistant performance is of importance to e.g. aviation, military and windscreen applications.

  3. Experimental techniques for design of impact-resistant material (poster)

    NARCIS (Netherlands)

    Fan, J.; Weerheijm, J.; Sluys, L.J.

    2013-01-01

    Some polymers are not only transparent and lightweight, but also impact and ballistic resistant. Designing and preparing such polymeric materials with a high impact‐resistant performance is of importance to e.g. aviation, military and windscreen applications.

  4. An innovative magnetorheological damper for automotive suspension: from design to experimental characterization

    Science.gov (United States)

    Sassi, Sadok; Cherif, Khaled; Mezghani, Lotfi; Thomas, Marc; Kotrane, Asma

    2005-08-01

    The development of a powerful new magnetorheological fluid (MRF), together with recent progress in the understanding of the behavior of such fluids, has convinced researchers and engineers that MRF dampers are among the most promising devices for semi-active automotive suspension vibration control, because of their large force capacity and their inherent ability to provide a simple, fast and robust interface between electronic controls and mechanical components. In this paper, theoretical and experimental studies are performed for the design, development and testing of a completely new MRF damper model that can be used for the semi-active control of automotive suspensions. The MR damper technology presented in this paper is based on a completely new approach where, in contrast to in the conventional solutions where the coil axis is usually superposed on the damper axis and where the inner cylindrical housing is part of the magnetic circuit, the coils are wound in a direction perpendicular to the damper axis. The paper investigates approaches to optimizing the dynamic response and provides experimental verification. Both experimental and theoretical results have shown that, if this particular model is filled with an 'MRF 336AG' MR fluid, it can provide large controllable damping forces that require only a small amount of energy. For a magnetizing system with four coils, the damping coefficient could be increased by up to three times for an excitation current of only 2 A. Such current could be reduced to less than 1 A if the magnetizing system used eight small cores. In this case, the magnetic field will be more powerful and more regularly distributed. In the presence of harmonic excitation, such a design will allow the optimum compromise between comfort and stability to be reached over different intervals of the excitation frequencies.

  5. Designing for Diverse Learning: Case Study of Place-Based Learning in Design and Technologies Pre-Service Teacher Education

    Science.gov (United States)

    Best, Marnie; MacGregor, Denise; Price, Deborah

    2017-01-01

    Place-based learning experiences in Design and Technologies education connect people and place with design processes and products. Drawing on place-based learning, this case study shares the experiences of eight final year pre-service Design and Technologies education students from the University of South Australia as they collaborated with…

  6. Lignocellulosic ethanol: Technology design and its impact on process efficiency.

    Science.gov (United States)

    Paulova, Leona; Patakova, Petra; Branska, Barbora; Rychtera, Mojmir; Melzoch, Karel

    2015-11-01

    This review provides current information on the production of ethanol from lignocellulosic biomass, with the main focus on relationships between process design and efficiency, expressed as ethanol concentration, yield and productivity. In spite of unquestionable advantages of lignocellulosic biomass as a feedstock for ethanol production (availability, price, non-competitiveness with food, waste material), many technological bottlenecks hinder its wide industrial application and competitiveness with 1st generation ethanol production. Among the main technological challenges are the recalcitrant structure of the material, and thus the need for extensive pretreatment (usually physico-chemical followed by enzymatic hydrolysis) to yield fermentable sugars, and a relatively low concentration of monosaccharides in the medium that hinder the achievement of ethanol concentrations comparable with those obtained using 1st generation feedstocks (e.g. corn or molasses). The presence of both pentose and hexose sugars in the fermentation broth, the price of cellulolytic enzymes, and the presence of toxic compounds that can inhibit cellulolytic enzymes and microbial producers of ethanol are major issues. In this review, different process configurations of the main technological steps (enzymatic hydrolysis, fermentation of hexose/and or pentose sugars) are discussed and their efficiencies are compared. The main features, benefits and drawbacks of simultaneous saccharification and fermentation (SSF), simultaneous saccharification and fermentation with delayed inoculation (dSSF), consolidated bioprocesses (CBP) combining production of cellulolytic enzymes, hydrolysis of biomass and fermentation into one step, together with an approach combining utilization of both pentose and hexose sugars are discussed and compared with separate hydrolysis and fermentation (SHF) processes. The impact of individual technological steps on final process efficiency is emphasized and the potential for use

  7. Sources of Experimental Variation in 2-D Maps: The Importance of Experimental Design in Gel-Based Proteomics.

    Science.gov (United States)

    Valcu, Cristina-Maria; Valcu, Mihai

    2016-01-01

    The success of proteomic studies employing 2-D maps largely depends on the way surveys and experiments have been organized and performed. Planning gel-based proteomic experiments involves the selection of equipment, methodology, treatments, types and number of samples, experimental layout, and methods for data analysis. A good experimental design will maximize the output of the experiment while taking into account the biological and technical resources available. In this chapter we provide guidelines to assist proteomics researchers in all these choices and help them to design quantitative 2-DE experiments.

  8. Physics Design of Water Moderator Criticality Assembly in Experimental Research About ADS

    Institute of Scientific and Technical Information of China (English)

    LV; Niu

    2013-01-01

    In order to meet the experimental demand of ADS research,we need to design a suitable criticality assembly.The key problem of the design work is the core design,we design a criticality assembly with the water moderator according to available nuclear material(Fig.1).The theoretical calculation have been

  9. Use of electronic nose technology to identify cattle experimentally infected with Mycobacterium bovis: A pilot study

    Science.gov (United States)

    Electronic nose technology has historically been utilized for the detection of volatile organic compounds (VOCs) and semi-volatile compounds in air, soil, water, and for quality control in food, beverage and cosmetic industries. Breath analysis has been used experimentally in humans and animals to ...

  10. The experimental and technological developments reactor; Le reacteur d'etudes et de developpements technologiques

    Energy Technology Data Exchange (ETDEWEB)

    Carbonnier, J.L. [CEA Cadarache, Dept. d' Etudes des Reacteurs (DEN/DER), 13 - Saint-Paul-lez-Durance (France)

    2003-07-01

    THis presentation concerns the REDT, gas coolant reactor for experimental and technological developments. The specifications and the research programs concerning this reactor are detailed;: materials, safety aspects, core physic, the corresponding fuel cycle, the reactor cycle and the program management. (A.L.B.)

  11. Technology transfer: taking science from the books to the ground at Bent Creek Experimental Forest

    Science.gov (United States)

    Julia Kirschman

    2014-01-01

    Technology transfer has been an important part of the research program at Bent Creek Experimental Forest (Bent Creek) since its establishment in 1925. Our stated mission is to develop and disseminate knowledge and strategies for restoring, managing, sustaining, and enhancing the vegetation and wildlife of upland hardwood-dominated forest ecosystems of the Southern...

  12. DESIGNING FEATURES OF POWER OPTICAL UNITS FOR TECHNOLOGICAL EQUIPMENT

    Directory of Open Access Journals (Sweden)

    M. Y. Afanasiev

    2016-03-01

    Full Text Available This paper considers the question of an optical unit designing for transmitting power laser radiation through an optical fiber. The aim of this work is designing a simple construction unit with minimized reflection losses. The source of radiation in the optical unit described below is an ultraviolet laser with diode pumping. We present the general functioning scheme and designing features for the three main parts: laser beam deflecting system, laser beam dump and optical unit control system. The described laser beam deflection system is composed of a moving flat mirror and a spherical scattering mirror. Comparative analysis of the production technology for such mirrors was carried out, and, as a result, the decision was made to produce both mirrors of 99.99 % pure molybdenum without coating. A moving mirror deflects laser emission from a source through a fiber or deflects it on a spherical mirror and into the laser beam dump, moreover, switching from one position to another occurs almost immediately. It is shown that a scattering mirror is necessary, otherwise, the absorbing surface of the beam dump is being worn out irregularly. The laser beam dump is an open conical cavity, in which the conical element with its spire turned to the emission source is placed. Special microgeometry of the internal surface of the beam dump is suggested for the better absorption effect. An optical unit control system consists of a laser beam deflection system, laser temperature sensor, deflection system solenoid temperature sensor, and deflection mirror position sensor. The signal processing algorithm for signals coming from the sensors to the controller is described. The optical unit will be used in special technological equipment.

  13. Nanowire piezo-phototronic photodetector: theory and experimental design.

    Science.gov (United States)

    Liu, Ying; Yang, Qing; Zhang, Yan; Yang, Zongyin; Wang, Zhong Lin

    2012-03-15

    The piezo-phototronic effect is about the use of the inner crystal piezoelectric potential to tune/control charge carrier generation, separation, transport and/or recombination in optoelectronic devices. In this paper, a theoretical model for describing the characteristics of a metal-nanowire-metal structured piezo-phototronic photodetector is constructed. Numerical simulations fit well to the experimental results of a CdS and ZnO nanowire based visible and UV detector, respectively.

  14. The Impact of Training Approaches on Experimental SetUp and Design of Wearable Vibrotactiles for Hunting Dogs

    DEFF Research Database (Denmark)

    Morrison, Ann Judith; Møller, Rune Heide; Manresa-Yee, Cristina

    2016-01-01

    While designing a wearable vibrotactile solution to assist canine navigation we encountered multiple conflicting dog training methods that impacted heavily on design possibilities as well as the methods used in the experimental design. The VibroTactile Vest (VTV), was designed in an iterative...... process to provide vibrotactile commands to dogs, working with variable-intensity vibrating motors mounted to a modified hug shirt to keep the vibrators close but not restrict movement. We folded knowledge gained from instructional scenarios with trainers, handlers and owners and from working directly...... with four hunting dogs who had been trained in either obedience, hunting, competitive or non-competitive styles into the finished design. We contribute to research that incorporates technology to enhance communication and mobility with working and companion animals. We increment foundational research...

  15. Reflector Technology Development and System Design for Concentrating Solar Power Technologies

    Energy Technology Data Exchange (ETDEWEB)

    Adam Schaut

    2011-12-30

    Alcoa began this program in March of 2008 with the goal of developing and validating an advanced CSP trough design to lower the levelized cost of energy (LCOE) as compared to existing glass based, space-frame trough technology. In addition to showing a pathway to a significant LCOE reduction, Alcoa also desired to create US jobs to support the emerging CSP industry. Alcoa's objective during Phase I: Concept Feasibility was to provide the DOE with a design approach that demonstrates significant overall system cost savings without sacrificing performance. Phase I consisted of two major tasks; reflector surface development and system concept development. Two specific reflective surface technologies were investigated, silver metallized lamination, and thin film deposition both applied on an aluminum substrate. Alcoa prepared samples; performed test validation internally; and provided samples to the NREL for full-spectrum reflectivity measurements. The final objective was to report reflectivity at t = 0 and the latest durability results as of the completion of Phase 1. The target criteria for reflectance and durability were as follows: (1) initial (t = 0), hemispherical reflectance >93%, (2) initial spectral reflectance >90% for 25-mrad reading and >87% for 7-mrad reading, and (3) predicted 20 year durability of less than 5% optical performance drop. While the results of the reflective development activities were promising, Alcoa was unable to down-select on a reflective technology that met the target criteria. Given the progress and potential of both silver film and thin film technologies, Alcoa continued reflector surface development activities in Phase II. The Phase I concept development activities began with acquiring baseline CSP system information from both CSP Services and the DOE. This information was used as the basis to develop conceptual designs through ideation sessions. The concepts were evaluated based on estimated cost and high-level structural

  16. Experimental Evaluation of Three Designs of Electrodynamic Flexural Transducers

    Science.gov (United States)

    Eriksson, Tobias J. R.; Laws, Michael; Kang, Lei; Fan, Yichao; Ramadas, Sivaram N.; Dixon, Steve

    2016-01-01

    Three designs for electrodynamic flexural transducers (EDFT) for air-coupled ultrasonics are presented and compared. An all-metal housing was used for robustness, which makes the designs more suitable for industrial applications. The housing is designed such that there is a thin metal plate at the front, with a fundamental flexural vibration mode at ∼50 kHz. By using a flexural resonance mode, good coupling to the load medium was achieved without the use of matching layers. The front radiating plate is actuated electrodynamically by a spiral coil inside the transducer, which produces an induced magnetic field when an AC current is applied to it. The transducers operate without the use of piezoelectric materials, which can simplify manufacturing and prolong the lifetime of the transducers, as well as open up possibilities for high-temperature applications. The results show that different designs perform best for the generation and reception of ultrasound. All three designs produced large acoustic pressure outputs, with a recorded sound pressure level (SPL) above 120 dB at a 40 cm distance from the highest output transducer. The sensitivity of the transducers was low, however, with single shot signal-to-noise ratio (SNR)≃15 dB in transmit–receive mode, with transmitter and receiver 40 cm apart. PMID:27571075

  17. Experimental Characterisation of Moreno Cross Slot Couplers for Blass Matrix Design

    Directory of Open Access Journals (Sweden)

    K. Jery Varghese

    1998-10-01

    Full Text Available This paper presents the experimental characterisation of Moreno cross-slot coupler which is the basic building block of multiple beam forming network (Blass matrix. The lack of exact theory of such coupler requires extensive experimental evaluation. A novel test jig has been designed, fabricated and tested for this purpose. The experimental results for different scattering parameters are presented.

  18. Using Propensity Scores in Quasi-Experimental Designs to Equate Groups

    Science.gov (United States)

    Lane, Forrest C.; Henson, Robin K.

    2010-01-01

    Education research rarely lends itself to large scale experimental research and true randomization, leaving the researcher to quasi-experimental designs. The problem with quasi-experimental research is that underlying factors may impact group selection and lead to potentially biased results. One way to minimize the impact of non-randomization is…

  19. "Using Power Tables to Compute Statistical Power in Multilevel Experimental Designs"

    Science.gov (United States)

    Konstantopoulos, Spyros

    2009-01-01

    Power computations for one-level experimental designs that assume simple random samples are greatly facilitated by power tables such as those presented in Cohen's book about statistical power analysis. However, in education and the social sciences experimental designs have naturally nested structures and multilevel models are needed to compute the…

  20. Optimization of preservatives in a topical formulation using experimental design.

    Science.gov (United States)

    Rahali, Y; Pensé-Lhéritier, A-M; Mielcarek, C; Bensouda, Y

    2009-12-01

    Optimizing the preservative regime for a preparation requires the antimicrobial effectiveness of several preservative combinations to be determined. In this study, three preservatives were tested: benzoic acid, sorbic acid and benzylic alcohol. Their preservative effects were evaluated using the antimicrobial preservative efficacy test (challenge-test) of the European Pharmacopeia (EP). A D-optimal mixture design was used to provide a maximum of information from a limited number of experiments. The results of this study were analysed with the help of the Design Expert software and enabled us to formulate emulsions satisfying both requirements A and B of the EP.