WorldWideScience

Sample records for technology exchange activities

  1. Program Integration for International Technology Exchange

    International Nuclear Information System (INIS)

    Rea, J.L.

    1993-01-01

    Sandia National Laboratories (SNL), Albuquerque, New Mexico, supports the International Technology Exchange Division (ITED) through the integration of all international activities conducted within the DOE's Office of Environmental Management (EM)

  2. Active microchannel heat exchanger

    Science.gov (United States)

    Tonkovich, Anna Lee Y [Pasco, WA; Roberts, Gary L [West Richland, WA; Call, Charles J [Pasco, WA; Wegeng, Robert S [Richland, WA; Wang, Yong [Richland, WA

    2001-01-01

    The present invention is an active microchannel heat exchanger with an active heat source and with microchannel architecture. The microchannel heat exchanger has (a) an exothermic reaction chamber; (b) an exhaust chamber; and (c) a heat exchanger chamber in thermal contact with the exhaust chamber, wherein (d) heat from the exothermic reaction chamber is convected by an exothermic reaction exhaust through the exhaust chamber and by conduction through a containment wall to the working fluid in the heat exchanger chamber thereby raising a temperature of the working fluid. The invention is particularly useful as a liquid fuel vaporizer and/or a steam generator for fuel cell power systems, and as a heat source for sustaining endothermic chemical reactions and initiating exothermic reactions.

  3. International Technology Exchange Division: 1993 Annual report

    International Nuclear Information System (INIS)

    1993-01-01

    The Office of Technology Development (OTD) was established to ensure that reliable and acceptable technologies are available for implementation at DOE sites and that a technically trained work force is available to complete the EM mission by 2019. OTD established the International Technology Exchange Staff (ITES) to identify, evaluate, and acquire international technologies which can accelerate US DOE cleanup operations. ITES's goal is to pursue international collaboration among government organizations, educational institutions, and private industry to identify world-wide needs and available technologies that will meet US environmental needs in general, and EM cleanup needs in particular; and establish mechanisms by which US government ER/WM technologies will be transferred to the US private sector for commercialization and export to international markets. ITES has developed the following strategic objectives to implement its international goals: develop and implement EM's policy for international programs in accordance with DOE and US Government policies and regulations; establish efficient and predictable international technology transfer mechanisms; assist the US private sector in the commercialization and deployment of federally funded EM technologies and related knowledge in international markets; leverage US and non-US resources to accelerate international development and regulatory acceptance of EM technologies; contribute to the improvement of EM's training of US students, scientists, and managers on international environmental issues. A summary and descriptions of program activities and accomplishments are given for 17 programs which comprise the four main areas of the ITES program: Activities with the Former Soviet Union, International Technology Transfer, International Cooperation, and Information Systems and Publications. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database

  4. Laser Processed Condensing Heat Exchanger Technology Development

    Science.gov (United States)

    Hansen, Scott; Wright, Sarah; Wallace, Sarah; Hamilton, Tanner; Dennis, Alexander; Zuhlke, Craig; Roth, Nick; Sanders, John

    2017-01-01

    The reliance on non-permanent coatings in Condensing Heat Exchanger (CHX) designs is a significant technical issue to be solved before long-duration spaceflight can occur. Therefore, high reliability CHXs have been identified by the Evolvable Mars Campaign (EMC) as critical technologies needed to move beyond low earth orbit. The Laser Processed Condensing Heat Exchanger project aims to solve these problems through the use of femtosecond laser processed surfaces, which have unique wetting properties and potentially exhibit anti-microbial growth properties. These surfaces were investigated to identify if they would be suitable candidates for a replacement CHX surface. Among the areas researched in this project include microbial growth testing, siloxane flow testing in which laser processed surfaces were exposed to siloxanes in an air stream, and manufacturability.

  5. Thermally activated technologies: Technology Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2003-05-01

    The purpose of this Technology Roadmap is to outline a set of actions for government and industry to develop thermally activated technologies for converting America’s wasted heat resources into a reservoir of pollution-free energy for electric power, heating, cooling, refrigeration, and humidity control. Fuel flexibility is important. The actions also cover thermally activated technologies that use fossil fuels, biomass, and ultimately hydrogen, along with waste heat.

  6. Written feedback as interaction: Knowledge exchange or activity exchange?

    Directory of Open Access Journals (Sweden)

    Sue Wharton

    2013-04-01

    Full Text Available This paper examines in-text, handwritten feedback comments on first year undergraduate writing in the discipline of Statistics. Using a small corpus of annotated assignments, I examine the grammar choices and content choices made by tutors as they comment on students’ work.  To better understand the purposes of the comments, I draw on an interview with a tutor. I make use of Halliday’s concepts of knowledge exchange and activity exchange to interpret the choices observed in the data, and the motivations discussed by the tutor, from the perspective of interaction. Finally, I discuss the implications of the analysis in terms of the formative potential of the feedback. 

  7. Active ageing technologies

    DEFF Research Database (Denmark)

    Lassen, Aske Juul

    ‘sites of active aging’ in Denmark. By presenting three technologies of active aging (billiards at an activity center for elderly persons, dancing tiles for rehabilitation after falls and an online fitness community for elderly persons) the paper suggests that active aging is more than regimes...... in their socio-material practices form active aging. Hence, active aging is a mutual entanglement (Callon and Rabeharisoa 2004) between technologies, practices and subjectivities. The paper is based on four months of participant observations and 17 in-depth interviews with elderly persons conducted at three...... of physical and productive activity; e.g. that a game of billiards is a technology of active aging. Thus, active aging is enacted in the socio-material practices of the technologies in this paper. The paper contributes with a strengthening of the concept of active aging, by focusing on entangled practices...

  8. Implications of WWW technologies for exchanging medical records

    Directory of Open Access Journals (Sweden)

    Maurice Dixon

    1999-09-01

    Full Text Available This article addresses some of the implications for medical record exchange of very recent developments in technology and tools that support the World Wide Web. It argues that XML (Extensible Mark-up Language is a very good enabling technology for medical record exchange. XML provides a much cheaper way of executing the exchange of medical information that circumvents the need for proprietary software. Use of XML can also simplify solutions to the problems associated with coping with the evolution of medical systems in time. However XML on its own does not resolve all the semantic heterogeneities.

  9. Exchange rate variability, market activity and heterogeneity

    OpenAIRE

    Rime, Dagfinn; Sucarrat, Genaro

    2007-01-01

    We study the role played by geographic and bank-size heterogeneity in the relation between exchange rate variability and market activity. We find some support for the hypothesis that increases in short-term global interbank market activity, which can be interpreted as due to variation in information arrival, increase variability. However, our results do not suggest that local short-term activity increases variability. With respect to long-term market activity, which can be interpreted as a me...

  10. INTERNATIONAL ENVIRONMENTAL TECHNOLOGY IDENTIFICATION, DEVELOPMENT, DEMONSTRATION, DEPLOYMENT AND EXCHANGE

    Energy Technology Data Exchange (ETDEWEB)

    Roy C. Herndon

    2001-02-28

    Cooperative Agreement (DE-FC21-95EW55101) between the U.S. Department of Energy (DOE) and the Florida State University's Institute for International Cooperative Environmental Research (IICER) was designed to facilitate a number of joint programmatic goals of both the DOE and the IICER related to international technology identification, development, demonstration and deployment using a variety of mechanisms to accomplish these goals. These mechanisms included: laboratory and field research; technology demonstrations; international training and technical exchanges; data collection, synthesis and evaluation; the conduct of conferences, symposia and high-level meetings; and other appropriate and effective approaches. The DOE utilized the expertise and facilities of the IICER at Florida State University to accomplish its goals related to this cooperative agreement. The IICER has unique and demonstrated capabilities that have been utilized to conduct the tasks for this cooperative agreement. The IICER conducted activities related to technology identification, development, evaluation, demonstration and deployment through its joint centers which link the capabilities at Florida State University with collaborating academic and leading research institutions in the major countries of Central and Eastern Europe (e.g., Czech Republic, Hungary, Poland) and Russia. The activities and accomplishments for this five-year cooperative agreement are summarized in this Final Technical Report.

  11. Active ageing technologies

    DEFF Research Database (Denmark)

    Lassen, Aske Juul

    In the recent decade the concept of active aging has become important in the Western hemisphere. The World Health Organization and The European Union have staged active aging as a core policy area and initiated programs of physical activity, independence and prolonged working lives among...... the elderly. As part of this rearticulation of old age, many new technologies take form. This paper uses a wide concept of technologies (devices, regimes, strategies and ways of doing) and argues that technologies form active aging subjectivities, and on the other hand, that these subjectivities...... in their socio-material practices form active aging. Hence, active aging is a mutual entanglement (Callon and Rabeharisoa 2004) between technologies, practices and subjectivities. The paper is based on four months of participant observations and 17 in-depth interviews with elderly persons conducted at three...

  12. Development of diffusion welded compact heat exchanger technology

    International Nuclear Information System (INIS)

    Mortean, M.V.V.; Cisterna, L.H.R.; Paiva, K.V.; Mantelli, M.B.H.

    2016-01-01

    Highlights: • Four new fabrication technologies for compact heat exchanger cores are presented. • The heat exchangers tested are fabricated by diffusion bonding process. • Results showed that cut-plate heat exchanger is the most promising technology. • Experimental results were compared favorably with numerical and analytical results. - Abstract: Compact heat exchangers are heat transfer equipment employed in applications where weight and volume are significantly relevant constraints, such as vehicles (automotive, maritime, avionics and space). The main characteristic of this equipment is the high heat transfer rate for small volumes. Only recently compact heat exchangers have received greater attention from the researchers, and therefore, manufacturing processes and mathematical modeling still demand development. The main objective of this work is to present and analyze four new fabrication technologies for compact heat exchanger cores, resulting in small cross sectional controlled geometry. Three of them consist of sandwiches of flat plates filled with: parallel circular wires, rectangular wires or rectangular tubes. The fourth consists of stacking flat plates interfiled with water jet machined plates. In all these procedures, stacks of metal layers are formed and diffusion bonding process is proposed for soldering. Copper prototypes were constructed to test the fabrication technologies. Results showed that stacking layers of machined comb-like plates interfiled with flat plates is the most promising fabrication technology, which was used to construct a copper prototype that was tested using water as both hot and cold fluids. The present technology was compared for both the volumetric power and the overall heat transfer coefficients with other heat exchangers, presenting an intermediate performance. Experimental results were compared favorably with numerical and analytical results from the literature.

  13. Semiautomatic exchanger of samples for carry out neutron activation analysis

    International Nuclear Information System (INIS)

    Aguilar H, F.; Quintana C, G.; Torres R, C. E.; Mejia J, J. O.

    2015-09-01

    In this paper the design methodology and implementation of a semiautomatic exchanger of samples for the Analysis Laboratory by Neutron Activation of the Reactor department is presented. Taking into account the antecedents, the necessities of improvement are described, as well as the equipment that previously contained the Laboratory. The project of the semiautomatic exchanger of samples was developed at Instituto Nacional de Investigaciones Nucleares, with its own technology to increase independence from commercial equipment. Each element of the semiautomatic exchanger of samples is described both in the design phase as construction. The achieved results are positive and encouraging for the fulfillment of the proposed objective that is to increase the capacity of the Laboratory. (Author)

  14. Compact heat exchanger technologies for the HTRs recuperator application

    International Nuclear Information System (INIS)

    Thonon, B.; Breuil, E.

    2001-01-01

    Modern HTR nuclear power plants which are now under development (projects GT-MHR, PBMR) are based on the direct cycle concept. This concept leads to a more important efficiency compared to the steam cycle but requires the use of high performance components such as an helium/helium heat exchanger called recuperator to guarantee the cycle efficiency. Using this concept, a net plant efficiency of around 50% can be achieved in the case of an electricity generating plant. As geometric constraints are particularly important for such a gas reactor to limit the size of the primary vessels, compact heat exchangers operating at high pressure and high temperature are attractive potential solutions for the recuperator application. In this frame, Framatome and CEA have reviewed the various technologies of compact heat exchangers used in industry. The first part of the paper will give a short description of the heat exchangers technologies and their ranges of application. In a second part, a selection of potential compact heat exchangers technologies are proposed for the recuperator application. This selection will be based upon their capabilities to cope with the operating conditions parameters (pressure, temperature, flow rate) and with other parameters such as fouling, corrosion, compactness, weight, maintenance and reliability. (author)

  15. Heat exchangers. Key factors, markets, technology and innovation policy

    Energy Technology Data Exchange (ETDEWEB)

    Finkbeiner, F.; Gonard, T.; Filiol, B.

    1993-01-01

    This book gives a diagnosis, at the european scale, of the heat exchanger industry, which plays a very important role in many systems and processes, and in most of the economical sectors. The various applicative markets involved are industry, transportation, and residential-tertiary sector. The recent technological developments are reviewed. 53 figs., 23 refs.

  16. 77 FR 36916 - Pilot Program for the Temporary Exchange of Information Technology Personnel

    Science.gov (United States)

    2012-06-20

    ... 0790-AI66 Pilot Program for the Temporary Exchange of Information Technology Personnel AGENCY... the Temporary Exchange of Information Technology Personnel, known as the Information Technology... Exchange of Information Technology (IT) Personnel. This statute authorizes the temporary assignment of DoD...

  17. ORGANIZATIONAL, LEGAL AND TECHNOLOGICAL ASPECTS OF HEALTH INFORMATION EXCHANGE

    Directory of Open Access Journals (Sweden)

    N. A. Karasev

    2017-01-01

    Full Text Available The article discusses organizational and legal aspects of electronic health information exchange in developed countries, particularly, introduction of electronic medical records in the United States and Europe, as well as topical issues related to standardization of information technologies in health care. We briefly describe the most popular standards used in e-medicine, such as Digital Imaging and Communications in Medicine (DICOM, openEHR and HL7. The questions of syntactic and semantic interoperability in the exchange of electronic medical records and some aspects of the digital signature use are also considered. We suggest mechanisms for implementation of electronic document management and sharing of digital medical information, as one of the most important directions of information technologies in health care. It is noted that today, the main limiting factor in providing the digital exchange of health information in Russian Federation is unresolved legal issues, i.e. the absence of a legal framework of electronic medical records share. At the same time, the level of IT development in our country is quite sufficient to meet current challenges. It is stated that, despite the unresolved number of problems (for example, completeness of medical data on a patient, given to relatives in critical situations, the adoption of a single electronic card is able to bring medical care to a new level, especially in emergency and urgent medicine.

  18. Enabling Detailed Energy Analyses via the Technology Performance Exchange: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Studer, D.; Fleming, K.; Lee, E.; Livingood, W.

    2014-08-01

    One of the key tenets to increasing adoption of energy efficiency solutions in the built environment is improving confidence in energy performance. Current industry practices make extensive use of predictive modeling, often via the use of sophisticated hourly or sub-hourly energy simulation programs, to account for site-specific parameters (e.g., climate zone, hours of operation, and space type) and arrive at a performance estimate. While such methods are highly precise, they invariably provide less than ideal accuracy due to a lack of high-quality, foundational energy performance input data. The Technology Performance Exchange was constructed to allow the transparent sharing of foundational, product-specific energy performance data, and leverages significant, external engineering efforts and a modular architecture to efficiently identify and codify the minimum information necessary to accurately predict product energy performance. This strongly-typed database resource represents a novel solution to a difficult and established problem. One of the most exciting benefits is the way in which the Technology Performance Exchange's application programming interface has been leveraged to integrate contributed foundational data into the Building Component Library. Via a series of scripts, data is automatically translated and parsed into the Building Component Library in a format that is immediately usable to the energy modeling community. This paper (1) presents a high-level overview of the project drivers and the structure of the Technology Performance Exchange; (2) offers a detailed examination of how technologies are incorporated and translated into powerful energy modeling code snippets; and (3) examines several benefits of this robust workflow.

  19. Pressurized fluidized-bed combustion technology exchange workshop

    Energy Technology Data Exchange (ETDEWEB)

    ,

    1980-04-01

    The pressurized fluidized-bed combustion technology exchange workshop was held June 5 and 6, 1979, at The Meadowlands Hilton Hotel, Secaucus, New Jersey. Eleven papers have been entered individually into EDB and ERA. The papers include reviews of the US DOE and EPRI programs in this area and papers by Swedish, West German, British and American organizations. The British papers concern the joint program of the USA, UK and FRG at Leatherhead. The key factor in several papers is the use of fluidized bed combustors, gas turbines, and steam turbines in combined-cycle power plants. One paper examines several combined-cycle alternatives. (LTN)

  20. HEALTH INFORMATION TECHNOLOGY IN EXCHANGE OF HEALTH INFORMATION

    Directory of Open Access Journals (Sweden)

    Jordan Deliversky

    2016-06-01

    Full Text Available Health information technology involves the exchange of health information in an electronic environment. Data protection is comprised of many elements, including where the data resides, how it is used, and who has access to it. Individually identifiable health information should be protected with reasonable administrative, technical, and physical safeguards to ensure its confidentiality, integrity, and availability and to prevent unauthorized access, use, or disclosure. Health records are among the most sensitive records available containing information concerning an individual. The unauthorized disclosure of a medical condition or diagnosis could negatively impact an individual’s personal and professional life.

  1. Investigation of Condensing Ice Heat Exchangers for MTSA Technology Development

    Science.gov (United States)

    Padilla, Sebastian; Powers, Aaron; Ball, Tyler; Lacomini, Christie; Paul, Heather L.

    2009-01-01

    Metabolic heat regenerated Temperature Swing Adsorption (MTSA) technology is being developed for thermal, carbon dioxide (CO2) and humidity control for a Portable Life Support Subsystem (PLSS). Metabolically-produced CO2 present in the ventilation gas of a PLSS is collected using a CO2-selective adsorbent via temperature swing adsorption. The temperature swing is initiated through cooling to well below metabolic temperatures. Cooling is achieved with a sublimation heat exchanger using water or liquid carbon dioxide (L CO2) expanded below sublimation temperature when exposed to low pressure or vacuum. Subsequent super heated vapor, as well as additional coolant, is used to further cool the astronaut. The temperature swing on the adsorbent is then completed by warming the adsorbent with a separate condensing ice heat exchanger (CIHX) using metabolic heat from moist ventilation gas. The condensed humidity in the ventilation gas is recycled at the habitat. The water condensation from the ventilation gas represents a significant source of potential energy for the warming of the adsorbent bed as it represents as much as half of the energy potential in the moist ventilation gas. Designing a heat exchanger to efficiently transfer this energy to the adsorbent bed and allow the collection of the water is a challenge since the CIHX will operate in a temperature range from 210K to 280K. The ventilation gas moisture will first freeze and then thaw, sometimes existing in three phases simultaneously.

  2. Liquid Salt Heat Exchanger Technology for VHTR Based Applications

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, Mark; Sridhara, Kumar; Allen, Todd; Peterson, Per

    2012-10-11

    The objective of this research is to evaluate performance of liquid salt fluids for use as a heat carrier for transferring high-temperature process heat from the very high-temperature reactor (VHTR) to chemical process plants. Currently, helium is being considered as the heat transfer fluid; however, the tube size requirements and the power associated with pumping helium may not be economical. Recent work on liquid salts has shown tremendous potential to transport high-temperature heat efficiently at low pressures over long distances. This project has two broad objectives: To investigate the compatibility of Incoloy 617 and coated and uncoated SiC ceramic composite with MgCl2-KCl molten salt to determine component lifetimes and aid in the design of heat exchangers and piping; and, To conduct the necessary research on the development of metallic and ceramic heat exchangers, which are needed for both the helium-to-salt side and salt-to-process side, with the goal of making these heat exchangers technologically viable. The research will consist of three separate tasks. The first task deals with material compatibility issues with liquid salt and the development of techniques for on-line measurement of corrosion products, which can be used to measure material loss in heat exchangers. Researchers will examine static corrosion of candidate materials in specific high-temperature heat transfer salt systems and develop an in situ electrochemical probe to measure metallic species concentrations dissolved in the liquid salt. The second task deals with the design of both the intermediate and process side heat exchanger systems. Researchers will optimize heat exchanger design and study issues related to corrosion, fabrication, and thermal stresses using commercial and in-house codes. The third task focuses integral testing of flowing liquid salts in a heat transfer/materials loop to determine potential issues of using the salts and to capture realistic behavior of the salts in a

  3. [No exchange of information without technology : modern infrastructure in radiology].

    Science.gov (United States)

    Hupperts, H; Hermann, K-G A

    2014-01-01

    Modern radiology cannot accomplish the daily numbers of examinations without supportive technology. Even though technology seems to be becoming increasingly more indispensable, business continuity should be ensured at any time and if necessary even with a limited technical infrastructure by business continuity management. An efficient information security management system forms the basis. The early radiology information systems were islands of information processing. A modern radiology department must be able to be modularly integrated into an informational network of a bigger organization. The secondary use of stored data for clinical decision-making support poses new challenges for the integrity of the data or systems because medical knowledge is displayed and provided in a context of treatment. In terms of imaging the creation and distribution radiology services work in a fully digital manner which is often different for radiology reports. Legally secure electronic diagnostic reports require a complex technical infrastructure; therefore, diagnostic findings still need to be filed as a paper document. The internal exchange and an improved dose management can be simplified by systems which continuously and automatically record the doses and thus provide the possibility of permanent analysis and reporting. Communication between patient and radiologist will gain ongoing importance. Intelligent use of technology will convey this to the radiologist and it will facilitate the understanding of the information by the patient.

  4. 75 FR 77753 - Pilot Program for the Temporary Exchange of Information Technology Personnel

    Science.gov (United States)

    2010-12-14

    ... Part 241 Pilot Program for the Temporary Exchange of Information Technology Personnel AGENCY... Program for the Temporary Exchange of Information Technology (IT) Personnel. This statute authorizes the... Information Technology Personnel,'' to implement the Pilot authorized by Section 1110. This Pilot will be...

  5. Developing maintenance technologies for FBR's heat exchanger units by advanced laser processing

    International Nuclear Information System (INIS)

    Nishimura, Akihiko; Shimada, Yukihiro

    2011-01-01

    Laser processing technologies were developed for the purpose of maintenance of FBR's heat exchanger units. Ultrashort laser processing fabricated fiber Bragg grating sensor for seismic monitoring. Fiber laser welding with a newly developed robot system repair cracks on inner wall of heat exchanger tubes. Safety operation of the heat exchanger units will be improved by the advanced laser processing technologies. These technologies are expected to be applied to the maintenance for the next generation FBRs. (author)

  6. Allosteric activation of coagulation factor VIIa visualized by hydrogen exchange

    DEFF Research Database (Denmark)

    Rand, Kasper Dyrberg; Jørgensen, Thomas; Olsen, Ole H

    2006-01-01

    Coagulation factor VIIa (FVIIa) is a serine protease that, after binding to tissue factor (TF), plays a pivotal role in the initiation of blood coagulation. We used hydrogen exchange monitored by mass spectrometry to visualize the details of FVIIa activation by comparing the exchange kinetics...

  7. An Exponential Increase in Regional Health Information Exchange With Collaborative Policies and Technologies.

    Science.gov (United States)

    Downing, N Lance; Lane, Steven; Eisenberg, Mathew; Sharp, Christopher; Palma, Jonathan; Longhurst, Christopher

    2015-01-01

    In the United States, the ability to securely exchange health information between organization has been limited by technical interoperability, patient identity matching, and variable institutional policies. Here, we examine the regional experience in a national health information exchange network by examining clinical data sharing between eleven Northern California organizations using the same health information exchange (HIE) platform between 2013-2014. We identify key policies and technologies that have led to a dramatic increase in health information exchange.

  8. Vitrification of ion exchange materials. Innovative technology summary report

    Energy Technology Data Exchange (ETDEWEB)

    1999-07-01

    Ion exchange is a process that safely and efficiently removes radionuclides from tank waste. Cesium and strontium account for a large portion of the radioactivity in waste streams from US Department of Energy (DOE) weapons production. Crystalline silicotitanate (CST) is an inorganic sorbent that strongly binds cesium, strontium, and several other radionuclides. Developed jointly by Sandia National Laboratory and Texas A and M University, CST was commercialized through a cooperative research and development agreement with an industrial partner. Both an engineered (mesh pellets) and powdered forms are commercially available. Cesium removal is a baseline in HLW treatment processing. CST is very effective at removing cesium from HLW streams and is being considered for adoption at several sites. However, CST is nonregenerable, and it presents a significant secondary waste problem. Treatment options include vitrification of the CST, vitrification of the CST coupled with HLW, direct disposal, and low-temperature processes such as grouting. The work presented in this report demonstrates that it is effective to immobilize CST using a baseline technology such as vitrification. Vitrification produces a durable waste form. CST vitrification was not demonstrated before 1996. In FY97, acceptable glass formulations were developed using cesium-loaded CST obtained from treating supernatants from Oak Ridge Reservation (ORR) tanks, and the CST was vitrified in a research melter at the Savannah River Technology Center (SRTC). In FY98, SRS decided to reevaluate the use of in-tank precipitation using tetraphenylborate to remove cesium from tank supernatant and to consider other options for cesium removal, including CST. Hanford and Idaho National Engineering and Environmental Laboratory also require radionuclide removal in their baseline flowsheets.

  9. Advances in processing technologies for titanium heat exchanger tubes of fossil and nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Likhareva, T.P.; Tchizhik, A.A.; Chavchanidze, N.N. [Polzanov Central Boiler and Turbine Institute, St. Petersburg (Russian Federation)

    1998-12-31

    The advances in processing technologies for titanium heat exchangers with rolled and welded tubes of fossil and nuclear power plants in Russia are presented. The special methodology of investigations with constant small strain rate have been used to study the effects of mixed corrosion and creep processes in condensers cooled by sea or synthetic sea waters. The results of corrosion creep tests and K1scc calculations are given. The Russian science activities concerning condensers manufactured from titanium show the possibilities for designing structures with very high level service reliability in different corrosion aggressive mediums with high total salt, Cl-ion and oxygen contents. (orig.)

  10. Steric effects in peptide and protein exchange with activated disulfides.

    Science.gov (United States)

    Kerr, Jason; Schlosser, Jessica L; Griffin, Donald R; Wong, Darice Y; Kasko, Andrea M

    2013-08-12

    Disulfide exchange is an important bioconjugation tool, enabling chemical modification of peptides and proteins containing free cysteines. We previously reported the synthesis of a macromer bearing an activated disulfide and its incorporation into hydrogels. Despite their ability to diffuse freely into hydrogels, larger proteins were unable to undergo in-gel disulfide exchange. In order to understand this phenomenon, we synthesized four different activated disulfide-bearing model compounds (Mn = 300 Da to 10 kDa) and quantified their rate of disulfide exchange with a small peptide (glutathione), a moderate-sized protein (β-lactoglobulin), and a large protein (bovine serum albumin) in four different pH solutions (6.0, 7.0, 7.4, and 8.0) to mimic biological systems. Rate constants of exchange depend significantly on the size and accessibility of the thiolate. pH also significantly affects the rate of reaction, with the faster reactions occurring at higher pH. Surprisingly, little difference in exchange rates is seen between macromolecular disulfides of varying size (Mn = 2 kDa - 10 kDa), although all undergo exchange more slowly than their small molecule analogue (MW = 300 g/mol). The maximum exchange efficiencies (% disulfides exchanged after 24 h) are not siginificantly affected by thiol size or pH, but somewhat affected by disulfide size. Therefore, while all three factors investigated (pH, disulfide size, and thiolate size) can influence the exchange kinetics and extent of reaction, the size of the thiolate and its accessibility plays the most significant role.

  11. Staff exchange with Spokane Intercollegiate Research and Technology Institute (SIRTI), final project report

    Energy Technology Data Exchange (ETDEWEB)

    Alexander, G.M.

    1994-12-01

    Staff exchanges, such as the one described in this report, are intended to facilitate communication and collaboration among scientists and engineers at Department of Energy (DOE) laboratories, in U.S. industry, and academia. Funding support for these exchanges is provided by the DOE, Office of Energy Research, Laboratory Technology Transfer Program. Funding levels for each exchange typically range from $20,000 to $40,000. The exchanges offer the opportunity for the laboratories to transfer technology and expertise to industry, gain a perspective on industry`s problems, and develop the basis for further cooperative efforts through Cooperative Research and Development Agreements (CRADAS) or other mechanisms.

  12. Japanese activities in refrigeration technology

    Science.gov (United States)

    Fujita, T.; Ohtsuka, T.; Ishizaki, Y.

    This paper reviews recent activities in refrigeration technology in Japan. The projects described are stimulated by growing industrial needs or form part of large national projects. The JNR project on the MAGLEV train is currently the most powerful activity and it demands knowledge in all the different disciplines of cryogenics in particular on various scales of refrigeration. Research activities are also directed towards the development of Stirling cycle and magnetic refrigerators for applications in a wider area.

  13. Brain Activities and Educational Technology

    Science.gov (United States)

    Riza, Emel

    2002-01-01

    There are close relationships between brain activities and educational technology. Brain is very important and so complicated part in our bodies. From long time scientists pay attention to that part and did many experiments, but they just reached little information like a drop in the sea. However from time to time they gave us some light to…

  14. NEURAL NETWORK TECHNOLOGY IN STUDY OF FOREIGN EXCHANGE MARKET

    Directory of Open Access Journals (Sweden)

    Eduard Dadyan

    2015-09-01

    Full Text Available In this paper we present the results of neural network analysis of the effect of significant factors on the quotation of the exchange rate on the example of the formation of the dollar in terms of «the turbulence of the economy» in Russia.

  15. LITERATURE REVIEWS TO SUPPORT ION EXCHANGE TECHNOLOGY SELECTION FOR MODULAR SALT PROCESSING

    Energy Technology Data Exchange (ETDEWEB)

    King, W

    2007-11-30

    This report summarizes the results of literature reviews conducted to support the selection of a cesium removal technology for application in a small column ion exchange (SCIX) unit supported within a high level waste tank. SCIX is being considered as a technology for the treatment of radioactive salt solutions in order to accelerate closure of waste tanks at the Savannah River Site (SRS) as part of the Modular Salt Processing (MSP) technology development program. Two ion exchange materials, spherical Resorcinol-Formaldehyde (RF) and engineered Crystalline Silicotitanate (CST), are being considered for use within the SCIX unit. Both ion exchange materials have been studied extensively and are known to have high affinities for cesium ions in caustic tank waste supernates. RF is an elutable organic resin and CST is a non-elutable inorganic material. Waste treatment processes developed for the two technologies will differ with regard to solutions processed, secondary waste streams generated, optimum column size, and waste throughput. Pertinent references, anticipated processing sequences for utilization in waste treatment, gaps in the available data, and technical comparisons will be provided for the two ion exchange materials to assist in technology selection for SCIX. The engineered, granular form of CST (UOP IE-911) was the baseline ion exchange material used for the initial development and design of the SRS SCIX process (McCabe, 2005). To date, in-tank SCIX has not been implemented for treatment of radioactive waste solutions at SRS. Since initial development and consideration of SCIX for SRS waste treatment an alternative technology has been developed as part of the River Protection Project Waste Treatment Plant (RPP-WTP) Research and Technology program (Thorson, 2006). Spherical RF resin is the baseline media for cesium removal in the RPP-WTP, which was designed for the treatment of radioactive waste supernates and is currently under construction in Hanford, WA

  16. LITERATURE REVIEWS TO SUPPORT ION EXCHANGE TECHNOLOGY SELECTION FOR MODULAR SALT PROCESSING

    International Nuclear Information System (INIS)

    King, W.

    2007-01-01

    This report summarizes the results of literature reviews conducted to support the selection of a cesium removal technology for application in a small column ion exchange (SCIX) unit supported within a high level waste tank. SCIX is being considered as a technology for the treatment of radioactive salt solutions in order to accelerate closure of waste tanks at the Savannah River Site (SRS) as part of the Modular Salt Processing (MSP) technology development program. Two ion exchange materials, spherical Resorcinol-Formaldehyde (RF) and engineered Crystalline Silicotitanate (CST), are being considered for use within the SCIX unit. Both ion exchange materials have been studied extensively and are known to have high affinities for cesium ions in caustic tank waste supernates. RF is an elutable organic resin and CST is a non-elutable inorganic material. Waste treatment processes developed for the two technologies will differ with regard to solutions processed, secondary waste streams generated, optimum column size, and waste throughput. Pertinent references, anticipated processing sequences for utilization in waste treatment, gaps in the available data, and technical comparisons will be provided for the two ion exchange materials to assist in technology selection for SCIX. The engineered, granular form of CST (UOP IE-911) was the baseline ion exchange material used for the initial development and design of the SRS SCIX process (McCabe, 2005). To date, in-tank SCIX has not been implemented for treatment of radioactive waste solutions at SRS. Since initial development and consideration of SCIX for SRS waste treatment an alternative technology has been developed as part of the River Protection Project Waste Treatment Plant (RPP-WTP) Research and Technology program (Thorson, 2006). Spherical RF resin is the baseline media for cesium removal in the RPP-WTP, which was designed for the treatment of radioactive waste supernates and is currently under construction in Hanford, WA

  17. The need to exchange experiences in nuclear technology

    International Nuclear Information System (INIS)

    Birkhofer, A.

    1991-01-01

    On December 7, 1965, H. Mandel invited members to the constituent session of the 'Committee for Exchanges of Operating Experience (ABE Committee)' of Working Group I of the Deutsches Atomforum. The proposal to institute regular exchanges of experience among all nuclear power plants under construction and in operation in the Federal Republic had come from A. Weckesser, Managing Director of the Gundremmingen Nuclear Power Station nearing completion at that time. The Committee was set up to improve the rather sporadic exchange of experience which had existed so far, especially with regard to the safety and availability of reactors, so that the results could be applied in practice systematically and a maximum level of operational safety could be achieved in this way. The annual reports of the 'Experiences with Nuclear Power Plants in the Federal Republic of Germany' ABE Committee were published each year in the 'atomwirtschaft' journal. In 1982, the ABE Committee was integrated into the Association of Large Power Plant Operators (Vereinigung der Grosskraftwerksbetreiber, VGB) as Technical Committee on 'Exchanges of Operating Experiences'. Twenty-five years of exchanges of experiences among German nuclear power plants have shown that the importance of such cooperation was recognized and utilized at an early point in time, even including foreign VGB members operating nuclear power plants. Improvement as a result of learning from experience and, consequently, also from past mistakes is an approach not to be followed ad libitum in the case of nuclear power plants, as the great hazard potential associated with the presence of radioactive fission products does not permit uncritical operation by trial and error. Instead, learning from experience in this case must be pursued in areas not associated with real accident hazards. This approach is perhaps best called learning in anticipation of hazards. (orig.) [de

  18. International Symposium for the Promotion of APEC Environmental Technology Exchange; APEC kankyo gijutsu koryu sokushin symposium

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-11-11

    The International Symposium for the Promotion of APEC Environmental Technology Exchange was held under the theme `The function and role expected of the APEC Virtual Center,` with the objectives of clarifying the need for future intra-regional environmental technological exchange, defining the types of information and personnel exchange, and promoting the use of interactive character of the APEC Virtual Center for Environmental Technology Exchange by encouraging access to and participation in the Virtual Center project. It was held in the period of 11th and 12th, November in 1996, at the venue of Rinku International Convention Center in Osaka. The symposium was attended by 477 persons from nine countries, i.e., Australia, Canada, China, Indonesia, Korea, Philippines, Thailand, the US, and Japan, comprising staff members of intra-regional environment-related organizations. After the keynote speech, `Current status and tasks of environmental technology exchange`, and `Expected roles of the Virtual Center for Environmental Technology Exchange` were discussed. During the plenary session, the chairman summarized the symposium. This summary was carried on the Virtual Center homepage of the Internet

  19. Use of communication technologies in document exchange for the management of construction projects

    Science.gov (United States)

    Mesároš, Peter; Mandičák, Tomáš

    2016-06-01

    Information and communication technologies represent a set of people, processes, technical and software tools providing collection, transport, storage and processing of data for distribution and presentation of information. Particularly communication systems are the main tool for information exchange. Of the other part, these technologies have a broad focus and use. One of them is the exchange of documents in the management of construction projects. Paper discusses the issue of exploitation level of communication technologies in construction project management. The main objective of this paper is to analyze exploitation level of communication technologies. Another aim of the paper is to compare exploitation level or rate of document exchange by electronic communication devices and face-to-face communication.

  20. Use of communication technologies in document exchange for the management of construction projects

    Directory of Open Access Journals (Sweden)

    Mesároš Peter

    2016-06-01

    Full Text Available Information and communication technologies represent a set of people, processes, technical and software tools providing collection, transport, storage and processing of data for distribution and presentation of information. Particularly communication systems are the main tool for information exchange. Of the other part, these technologies have a broad focus and use. One of them is the exchange of documents in the management of construction projects. Paper discusses the issue of exploitation level of communication technologies in construction project management. The main objective of this paper is to analyze exploitation level of communication technologies. Another aim of the paper is to compare exploitation level or rate of document exchange by electronic communication devices and face-to-face communication.

  1. Newest technology in cadastral activities

    Directory of Open Access Journals (Sweden)

    В. А. Павлова

    2017-06-01

    Full Text Available The article provides comparative analysis of multiple innovative technology in the field of cadaster activities. This analysis covers almost all currently available intellectual developments in this area. Paying tribute to contemporary trends in cadastral areas, the authors note the urgent need to upgrade the cadastral activities in the Russian Federation in relation to the transformation of the national economy. The authors suggest classifying the cadastral activities depending on type and kind of activity carried out with an object of cadaster registry. The article covers the most urgent issues in the area of functionality of existing special software packages in order to improve the labour efficiency of a cadaster engineer. It is concluded that the main purpose of existing software systems for cadastral engineers is creation of documents in electronic format for facilitating the process of interaction with public authorities in the sphere of land property relations. It examines in detail several software packages («TechnoKad-Express», «ARGO», «PKZO», «Poligon», «ProGeo». The article provides comparative analysis of special software systems according to a number of authors’ criteria. Based on the characteristics of programs and their comparative analysis, it is concluded that all the described software systems to greater or lesser degree, meet the needs of the working cadastral engineer. The choice of a specific program depends on the financial possibilities, personal preferences and level of computer-literacy of cadastral engineer, including in the sphere of GIS-technologies.

  2. Manufacture of power station heat exchangers using modern production technology

    International Nuclear Information System (INIS)

    Genzlinger, W.; Hoffmann, J.; Ohlhaeuser, K.

    1986-01-01

    Heat exchangers of high quality and operational safety can only be fabricated economically if fabrication is as 'simple' as possible and can be controlled and if, through value analysis, the work flows can be mechanized and automated and the following requirements are met: use of materials that are easy to work with for the application considered, choice of product designs and wall thicknesses that offer favourable conditions for processing and non-destructive testing, placing of seams in such a way that good accessibility for welding and minimum residual welding stresses are assured, minimizing the number of welding seams, use of automatic welding machines for submerged-arc welding and electronically controlled sources of welding current - semi-automatic equipment for spatter-free interfaces (pulse technique), electronically controlled equipment for welding in rollers and pipes and CNC-controlled machining centres for drilling pipe galleries (deep-hole drilling) and baffle plates and for machining the sealing elements after welding. Continuous inspections in each phase of fabrication assures that heat exchangers are made which fully meet the requirements of nuclear power station operators. (orig.)

  3. Development of a micro-heat exchanger with stacked plates using LTCC technology

    Directory of Open Access Journals (Sweden)

    E. Vásquez-Alvarez

    2010-09-01

    Full Text Available A green ceramic tape micro-heat exchanger was developed using Low Temperature Co-fired Ceramics technology (LTCC. The device was designed by using Computational Aided Design software and simulations were made using a Computational Fluid Dynamics package (COMSOL Multiphysics to evaluate the homogeneity of fluid distribution in the microchannels. Four geometries were proposed and simulated in two and three dimensions to show that geometric details directly affect the distribution of velocity in the micro-heat exchanger channels. The simulation results were quite useful for the design of the microfluidic device. The micro-heat exchanger was then constructed using the LTCC technology and is composed of five thermal exchange plates in cross-flow arrangement and two connecting plates, with all plates stacked to form a device with external dimensions of 26 x 26 x 6 mm³.

  4. A distributed framework for health information exchange using smartphone technologies.

    Science.gov (United States)

    Abdulnabi, Mohamed; Al-Haiqi, Ahmed; Kiah, M L M; Zaidan, A A; Zaidan, B B; Hussain, Muzammil

    2017-05-01

    Nationwide health information exchange (NHIE) continues to be a persistent concern for government agencies, despite the many efforts and the conceived benefits of sharing patient data among healthcare providers. Difficulties in ensuring global connectivity, interoperability, and concerns on security have always hampered the government from successfully deploying NHIE. By looking at NHIE from a fresh perspective and bearing in mind the pervasiveness and power of modern mobile platforms, this paper proposes a new approach to NHIE that builds on the notion of consumer-mediated HIE, albeit without the focus on central health record banks. With the growing acceptance of smartphones as reliable, indispensable, and most personal devices, we suggest to leverage the concept of mobile personal health records (PHRs installed on smartphones) to the next level. We envision mPHRs that take the form of distributed storage units for health information, under the full control and direct possession of patients, who can have ready access to their personal data whenever needed. However, for the actual exchange of data with health information systems managed by healthcare providers, the latter have to be interoperable with patient-carried mPHRs. Computer industry has long ago solved a similar problem of interoperability between peripheral devices and operating systems. We borrow from that solution the idea of providing special interfaces between mPHRs and provider systems. This interface enables the two entities to communicate with no change to either end. The design and operation of the proposed approach is explained. Additional pointers on potential implementations are provided, and issues that pertain to any solution to implement NHIE are discussed. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. History of establishment of scientific technology law focused on exchanges of Korea, China and Japan

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Gyeong Hui

    1990-10-15

    This book introduces science and technology promotion related law, industrial technology related law, resources and energy related law, nuclear energy related law, information and communication related law, intellectual property right related law, and environment related law. It explains process of development of 7 laws in threes countries and relations of three countries exchanges. It also covers special law for science and technology innovation, electric utility law, petroleum enterprise law, telecommunication related law, law of settlement of digital divide, and information-oriented law.

  6. History of establishment of scientific technology law focused on exchanges of Korea, China and Japan

    International Nuclear Information System (INIS)

    Lee, Gyeong Hui

    1990-10-01

    This book introduces science and technology promotion related law, industrial technology related law, resources and energy related law, nuclear energy related law, information and communication related law, intellectual property right related law, and environment related law. It explains process of development of 7 laws in threes countries and relations of three countries exchanges. It also covers special law for science and technology innovation, electric utility law, petroleum enterprise law, telecommunication related law, law of settlement of digital divide, and information-oriented law.

  7. Analysis of the Technological Parameters of the Heat Exchanger in the Heating Pipe

    Directory of Open Access Journals (Sweden)

    Knyazev Vladimir

    2017-01-01

    Full Text Available The main purpose of this article is to analyze the selecting of technological parameters for the heat exchanger to improve the heat transfer and reduce the noise during operation in the heating pipe, which is used in the different systems of the planes and helicopters. In result of this study, the best technical parameters are found, considering different variations of deformation cutting heat exchanger pipes.

  8. Electrochemical ion-exchange for medium active liquid waste treatment

    International Nuclear Information System (INIS)

    Bridger, N.J.; Turner, A.D.

    1987-01-01

    Electrochemical ion-exchange has already been demonstrated to be a robust, effective process for the treatment of active liquid wastes -with high decontamination and volume reduction factors, and only a low energy requirement. The primary aim of this new programme is to scale up this process - initially to 0.1m 3 /h, and ultimately to 1 3 m/h. A new 0.4m 2 electrode module has been designed and constructed, together with 3m 3 feed tanks for the first phase of this work. Further development work is also being carried out on alternative electrode designs and fabrication methods, as well as new exchange media (including inorganic absorbers and organic chelating resins) in order to optimize selectivity performance. (author)

  9. Proton exchange membrane fuel cell technology for transportation applications

    Energy Technology Data Exchange (ETDEWEB)

    Swathirajan, S. [General Motors R& D Center, Warren, MI (United States)

    1996-04-01

    Proton Exchange Membrane (PEM) fuel cells are extremely promising as future power plants in the transportation sector to achieve an increase in energy efficiency and eliminate environmental pollution due to vehicles. GM is currently involved in a multiphase program with the US Department of Energy for developing a proof-of-concept hybrid vehicle based on a PEM fuel cell power plant and a methanol fuel processor. Other participants in the program are Los Alamos National Labs, Dow Chemical Co., Ballard Power Systems and DuPont Co., In the just completed phase 1 of the program, a 10 kW PEM fuel cell power plant was built and tested to demonstrate the feasibility of integrating a methanol fuel processor with a PEM fuel cell stack. However, the fuel cell power plant must overcome stiff technical and economic challenges before it can be commercialized for light duty vehicle applications. Progress achieved in phase I on the use of monolithic catalyst reactors in the fuel processor, managing CO impurity in the fuel cell stack, low-cost electrode-membrane assembles, and on the integration of the fuel processor with a Ballard PEM fuel cell stack will be presented.

  10. U.S. Department of Energy national technology information exchange workshops

    International Nuclear Information System (INIS)

    Daub, G.J.; Earle, S.D.; Smibert, A.M.; Wight, E.H.

    1994-01-01

    The U.S. Department of Energy National Technology Information Exchange (TIE) Workshops bring together environmental restoration and technology development personnel to exchange and share problems, needs, technological solutions, ideas, and successes and failures from lessons learned at DOE sites. The success of this forum is measured by the knowledge gained, contacts made, and program dollars saved by the people who actually do the work in the field. TIE is a unique opportunity to unite the DOE community and allow individuals to listen and to learn about each others' problems and solutions. By using today's technologies better, the National TIE Workshops help identify and implement cost-effective and appropriate technologies to meet the needs of the DOE environmental restoration program

  11. Effect of Air Cleaning Technologies in Conjunction With the Use of Rotary Heat Exchangers in Residential Buildings

    DEFF Research Database (Denmark)

    Afshari, Alireza; Bergsøe, Niels Christian; Ekberg, Lars

    2013-01-01

    with rotary air-to-air heat exchangers. For this purpose, a mechanical filter with low pressure drop and a 4 cm thick activated carbon filter were selected for testing in a laboratory environment. The measurements included testing of the filters, separately and combined, in a ductwork to study the efficiency......This study is part of a research project concerning the possibilities of applying efficient air cleaning technologies using rotary heat exchanger in residential buildings. The purpose of this project was to identify and adapt new air-cleaning technologies for implementation in HVAC systems...... was approximately 5 Pascal at an airflow rate of 216 m3/h. The air velocity through the filter was 0.49 m/s. Furthermore, the removal efficiency of the combined filter for 6 chemical substances were examined using Hexane, Butanol, 2-Ethylhexanol, Heptane, 2-Heptanone and Acetaldehyde as sources for emission...

  12. Simulacra, Symbolic Exchange and Technology in Michel Tournier's La Goutte d'Or

    Directory of Open Access Journals (Sweden)

    David W. Price

    1993-06-01

    Full Text Available In La Goutte d'Or , Michel Tournier offers a critique of Western culture by constructing a novel that reflects both Jean Baudrillard's theories of simulacra and the political economy of the sign and Martin Heidegger's meditations on technology. Tournier's novel explores the relationship between Heidegger's explanation of technology as an act of Enframing ( Ge-stell and Baudrillard's description of an economy based upon exchange-sign value. Thus, through La Goutte d 'Or , Michel Tournier depicts the violent confrontation between a symbolic exchange economy based on poietic acts and late capitalist economies of autonomized signs.

  13. Commercialization of proton exchange membrane (PEM) fuel cell technology

    International Nuclear Information System (INIS)

    Goel, N.; Pant, A.; Sera, G.

    1995-01-01

    The MCTTC performed a market assessment for PEM Fuel Cells for terrestrial applications for the Center for Space Power (CSP). The purpose of the market assessment was to gauge the market and commercial potential for PEM fuel cell technology. Further, the market assessment was divided into subsections of technical and market overview, competitive environment, political environment, barriers to market entry, and keys to market entry. The market assessment conducted by the MCTTC involved both secondary and primary research. The primary target markets for PEM fuel cells were transportation and utilities in the power range of 10 kW to 100 kW. The fuel cell vehicle market size was estimated under a pessimistic scenario and an optimistic scenario. The estimated size of the fuel cell vehicle market in dollar terms for the year 2005 is $17.3 billion for the pessimistic scenario and $34.7 billion for the optimistic scenario. The fundamental and applied research funded and conducted by the National Aeronautics and Space Administration (NASA) and DOE in the area of fuel cells presents an excellent opportunity to commercialize dual-use technology and enhance U.S. business competitiveness. copyright 1995 American Institute of Physics

  14. Active osmotic exchanger for advanced filtration at the nano scale

    Science.gov (United States)

    Marbach, Sophie; Bocquet, Lyderic

    2015-11-01

    One of the main functions of the kidney is to remove the waste products of an organism, mostly by excreting concentrated urea while reabsorbing water and other molecules. The human kidney is capable of recycling about 200 liters of water per day, at the relatively low cost of 0.5 kJ/L (standard dialysis requiring at least 150 kJ/L). Kidneys are constituted of millions of parallel filtration networks called nephrons. The nephrons of all mammalian kidneys present a specific loop geometry, the Loop of Henle, that is believed to play a key role in the urinary concentrating mechanism. One limb of the loop is permeable to water and the other contains sodium pumps that exchange with a common interstitium. In this work, we take inspiration from this osmotic exchanger design to propose new nanofiltration principles. We first establish simple analytical results to derive general operating principles, based on coupled water permeable pores and osmotic pumps. The best filtration geometry, in terms of power required for a given water recycling ratio, is comparable in many ways to the mammalian nephron. It is not only more efficient than traditional reverse osmosis systems, but can also work at much smaller pressures (of the order of the blood pressure, 0.13 bar, as compared to more than 30 bars for pressure-retarded osmosis systems). We anticipate that our proof of principle will be a starting point for the development of new filtration systems relying on the active osmotic exchanger principle.

  15. Control Robotics Programming Technology. Technology Learning Activity. Teacher Edition.

    Science.gov (United States)

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This Technology Learning Activity (TLA) for control robotics programming technology in grades 6-10 is designed to teach students to construct and program computer-controlled devices using a LEGO DACTA set and computer interface and to help them understand how control technology and robotics affect them and their lifestyle. The suggested time for…

  16. Structural analyses of a constitutively active mutant of exchange protein directly activated by cAMP.

    Science.gov (United States)

    White, Mark A; Li, Sheng; Tsalkova, Tamara; Mei, Fang C; Liu, Tong; Woods, Virgil L; Cheng, Xiaodong

    2012-01-01

    Exchange proteins directly activated by cAMP (EPACs) are important allosteric regulators of cAMP-mediated signal transduction pathways. To understand the molecular mechanism of EPAC activation, we have combined site-directed mutagenesis, X-ray crystallography, and peptide amide hydrogen/deuterium exchange mass spectrometry (DXMS) to probe the structural and conformational dynamics of EPAC2-F435G, a constitutively active EPAC2 mutant. Our study demonstrates that conformational dynamics plays a critical role in cAMP-induced EPAC activation. A glycine mutation at 435 position shifts the equilibrium of conformational dynamics towards the extended active conformation.

  17. Structural analyses of a constitutively active mutant of exchange protein directly activated by cAMP.

    Directory of Open Access Journals (Sweden)

    Mark A White

    Full Text Available Exchange proteins directly activated by cAMP (EPACs are important allosteric regulators of cAMP-mediated signal transduction pathways. To understand the molecular mechanism of EPAC activation, we have combined site-directed mutagenesis, X-ray crystallography, and peptide amide hydrogen/deuterium exchange mass spectrometry (DXMS to probe the structural and conformational dynamics of EPAC2-F435G, a constitutively active EPAC2 mutant. Our study demonstrates that conformational dynamics plays a critical role in cAMP-induced EPAC activation. A glycine mutation at 435 position shifts the equilibrium of conformational dynamics towards the extended active conformation.

  18. Advanced Heat/Mass Exchanger Technology for Geothermal and Solar Renewable Energy Systems

    Energy Technology Data Exchange (ETDEWEB)

    Greiner, Miles [Univ. of Nevada, Reno, NV (United States); Childress, Amy [Univ. of Nevada, Reno, NV (United States); Hiibel, Sage [Univ. of Nevada, Reno, NV (United States); Kim, Kwang [Univ. of Nevada, Reno, NV (United States); Park, Chanwoo [Univ. of Nevada, Reno, NV (United States); Wirtz, Richard [Univ. of Nevada, Reno, NV (United States)

    2014-12-16

    Northern Nevada has abundant geothermal and solar energy resources, and these renewable energy sources provide an ample opportunity to produce economically viable power. Heat/mass exchangers are essential components to any energy conversion system. Improvements in the heat/mass exchange process will lead to smaller, less costly (more efficient) systems. There is an emerging heat transfer technology, based on micro/nano/molecular-scale surface science that can be applied to heat/mass exchanger design. The objective is to develop and characterize unique coating materials, surface configurations and membranes capable of accommodating a 10-fold increase in heat/mass exchanger performance via phase change processes (boiling, condensation, etc.) and single phase convective heat/mass transfer.

  19. Identity Orientation, Social Exchange, and Information Technology Use in Interorganizational Collaborations

    DEFF Research Database (Denmark)

    Gal, Uri; Jensen, Tina Blegind; Lyytinen, Kalle

    2014-01-01

    identity orientations. To address this gap, we conduct multiple case studies that describe the changing use of two-dimensional computer-aided design technology and new three-dimensional modeling technologies by a leading metal fabrication company in the architecture, engineering, and construction industry....... The case studies demonstrate that changes in the company's IT and the enactment of related IT affordances within variable interorganizational contexts enable new forms of social exchanges. These exchanges, in turn, provide the context for the rearticulation of the company's identity orientation. Based...... on these insights, we formulate a theoretical model to delineate the relationships between IT use, IT affordances, social exchanges, and identity orientation. We conclude by outlining the implications of our study and suggesting possible avenues for future research....

  20. Frameworks and technologies for exchanging and sharing product life cycle knowledge

    NARCIS (Netherlands)

    Gerritsen, B.; Gielingh, W.; Dankwort, W.; Anderl, R.

    2011-01-01

    Frameworks and technologies for exchanging and sharing product life cycle knowledge (PLK) are discussed. A life cycle-centric knowledge management approach with stakeholders-in-the-loop allows for a life-long evaluation of the instantaneous performance and the consequential decision making about the

  1. Optical activity studies of hydrogen-deuterium exchange

    International Nuclear Information System (INIS)

    Hansen, L.J.

    1990-01-01

    The potassium complexes of racemic and optically active forms of 1,2-propanediaminetriacetatoacetic acid nickel-ate (II) were prepared stoichiometrically by two different experimental procedures. The complexes were characterized by UV-VIS absorption spectroscopy, infrared spectroscopy, and thermal analysis. Circular dichroism and optical rotatory dispersion values were obtained on the optically active complexes. TGA and IR spectroscopy techniques suggest that Δ-K [Ni(R (-)HPDTA)] H 2 O (1)and Λ-K [Ni(S (+)HPDTA)] H 2 O (2) have different configurations in solution than in the solid state. Solid complexes of (1) are theorized to have the nickel (II) ion bound pentadentate to the PDTA ligand and unidentate to a water molecule. The free carboxyl arm of the PDTA ligand is protonated. Dissolution of the complexes results in rotational changes which occur with time. The rate of rotational change has been kinetically measured, which results in three pH dependent rate constants. An isotope effect for such reactions in H 2 O and D 2 O has been measured. The base-catalyzed hydrogen-deuterium exchange of the out-of-plane glycinate rings of (1) and (2) complexes has been determined for three of the four glycinate protons by ORD. The rate of hydrogen-deuterium exchange is extremely slow and consecutive proton exchanges are not independent of one another over sufficiently long periods, such that measurement of α ∞ are calculated by three differing mathematical models and applied to the calculation of the hydrogen-deuterium rate constants

  2. The impact of technological improvements on developing financial markets: The case of the Johannesburg Stock Exchange

    Directory of Open Access Journals (Sweden)

    Mehmet F. Dicle

    2013-07-01

    Full Text Available Can a significant technological improvement make an economically justifiable contribution to a financial market's development? The Johannesburg Stock Exchange (JSE incorporated the SETS system from the London Stock Exchange in 2002. It is certain that SETS is a technologically efficient trading system, and it would undoubtedly improve trading in the JSE. We test whether SETS represents a structural break by examining whether there was an increase in the JSE's liquidity, market efficiency and international integration after the introduction of SETS. While SETS is certainly a technological improvement with increased liquidity, it is not a sufficient factor to render it efficient. After the incorporation of SETS, the JSE has become more independent and it now offers better diversification opportunities for international investors.

  3. The mechanics of motorised momentum exchange tethers when applied to active debris removal from LEO

    International Nuclear Information System (INIS)

    Caldecott, Ralph; Kamarulzaman, Dayangku N. S.; Kirrane, James P.; Cartmell, Matthew P.; Ganilova, Olga A.

    2014-01-01

    The concept of momentum exchange when applied to space tethers for propulsion is well established, and a considerable body of literature now exists on the on-orbit modelling, the dynamics, and also the control of a large range of tether system applications. The authors consider here a new application for the Motorised Momentum Exchange Tether by highlighting three key stages of development leading to a conceptualisation that can subsequently be developed into a technology for Active Debris Removal. The paper starts with a study of the on-orbit mechanics of a full sized motorised tether in which it is shown that a laden and therefore highly massasymmetrical tether can still be forced to spin, and certainly to librate, thereby confirming its possible usefulness for active debris removal (ADR). The second part of the paper concentrates on the modelling of the centripetal deployment of a symmetrical MMET in order to get it initialized for debris removal operations, and the third and final part of the paper provides an entry into scale modelling for low cost mission design and testing. It is shown that the motorised momentum exchange tether offers a potential solution to the removal of large pieces of orbital debris, and that dynamic methodologies can be implemented to in order to optimise the emergent design

  4. Technology Development Roadmap for the Advanced High Temperature Reactor Secondary Heat Exchanger

    Energy Technology Data Exchange (ETDEWEB)

    P. Sabharwall; M. McCllar; A. Siahpush; D. Clark; M. Patterson; J. Collins

    2012-09-01

    This Technology Development Roadmap (TDRM) presents the path forward for deploying large-scale molten salt secondary heat exchangers (MS-SHX) and recognizing the benefits of using molten salt as the heat transport medium for advanced high temperature reactors (AHTR). This TDRM will aid in the development and selection of the required heat exchanger for: power production (the first anticipated process heat application), hydrogen production, steam methane reforming, methanol to gasoline production, or ammonia production. This TDRM (a) establishes the current state of molten salt SHX technology readiness, (b) defines a path forward that systematically and effectively tests this technology to overcome areas of uncertainty, (c) demonstrates the achievement of an appropriate level of maturity prior to construction and plant operation, and (d) identifies issues and prioritizes future work for maturing the state of SHX technology. This study discusses the results of a preliminary design analysis of the SHX and explains the evaluation and selection methodology. An important engineering challenge will be to prevent the molten salt from freezing during normal and off-normal operations because of its high melting temperature (390°C for KF ZrF4). The efficient transfer of energy for industrial applications depends on the ability to incorporate cost-effective heat exchangers between the nuclear heat transport system and industrial process heat transport system. The need for efficiency, compactness, and safety challenge the capabilities of existing heat exchanger technology. The description of potential heat exchanger configurations or designs (such as printed circuit, spiral or helical coiled, ceramic, plate and fin, and plate type) were covered in an earlier report (Sabharwall et al. 2011). Significant future work, much of which is suggested in this report, is needed before the benefits and full potential of the AHTR can be realized. The execution of this TDRM will focuses

  5. Technological aspects of vegetable oils epoxidation in the presence of ion exchange resins: a review

    Directory of Open Access Journals (Sweden)

    Milchert Eugeniusz

    2016-09-01

    Full Text Available A review paper of the technology basics of vegetable oils epoxidation by means of peracetic or performic acid in the presence of acidic ion exchange resins has been presented. The influence of the following parameters: temperature, molar ratio of acetic acid and hydrogen peroxide to ethylenic unsaturation, catalyst loading, stirring intensity and the reaction time on a conversion of ethylenic unsaturation, the relative percentage conversion to oxirane and the iodine number was discussed. Optimal technological parameters, mechanism of epoxidation by carboxylic peracids and the possibilities of catalyst recycling have been also discussed. This review paper shows the application of epoxidized oils.

  6. Report on investigation in fiscal 2000 of industrial technology exchange with international networking organizations; 2000 nendo kokusaitekina network gata soshiki tono sangyo gijutsu koryu chosa hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    With an objective to promote exchange of industrial technologies, investigations and analyses were made on identification of the current status of networking organizations in different countries working as windows for industrial technology exchange, and on the actual status of technology commercialization methods in overseas incubators. Activities were taken in the following three fields: 1) the current status of networking organizations and incubators in different countries, 2) typology of technology commercialization, technical fields, and success factors, and 3) possibility of the use of technology information in the networking organizations. In Item 1), investigations were performed on the current status and actual activity status of the networking organizations including research parks and individual incubators intended of information exchange, mainly in the United States, UK, and Finland. In Item 2), considerations are given on the points related to technology incubation based on the information about the networking organizations and incubators in each country, and the way the industry-academia cooperation should be. In Item 3), discussions were given on the roles of the networking organizations and the possibility of utilization of technological information in the networking organizations in Japan. (NEDO)

  7. Joint research and development and exchange of technology on toxic material emergency response between LLNL and ENEA. 1985 progress report

    International Nuclear Information System (INIS)

    Dickerson, M.H.; Caracciolo, R.

    1986-01-01

    For the past six years, the US Department of Energy, LLNL, and the ENEA, Rome, Italy, have participated in cooperative studies for improving a systems approach to an emergency response following nuclear accidents. Technology exchange between LLNL and the ENEA was initially confined to the development, application, and evaluation of atmospheric transport and diffusion models. With the emergence of compatible hardware configurations between LLNL and ENEA, exchanges of technology and ideas for improving the development and implementation of systems are beginning to emerge. This report describes cooperative work that has occurred during the past three years, the present state of each system, and recommendations for future exchanges of technology

  8. International technology exchange in support of the Defense Waste Processing Facility wasteform production

    International Nuclear Information System (INIS)

    Kitchen, B.G.

    1989-01-01

    The nearly completed Defense Waste Processing Facility (DWPF) is a Department of Energy (DOE) facility at the Savannah River Site that is designed to immobilize defense high level radioactive waste (HLW) by vitrification in borosilicate glass and containment in stainless steel canisters suitable for storage in the future DOE HLW repository. The DWPF is expected to start cold operation later this year (1990), and will be the first full scale vitrification facility operating in the United States, and the largest in the world. The DOE has been coordinating technology transfer and exchange on issues relating to HLW treatment and disposal through bi-lateral agreements with several nations. For the nearly fifteen years of the vitrification program at Savannah River Laboratory, over two hundred exchanges have been conducted with a dozen international agencies involving about five-hundred foreign national specialists. These international exchanges have been beneficial to the DOE's waste management efforts through confirmation of the choice of the waste form, enhanced understanding of melter operating phenomena, support for paths forward in political/regulatory arenas, confirmation of costs for waste form compliance programs, and establishing the need for enhancements of melter facility designs. This paper will compare designs and schedules of the international vitrification programs, and will discuss technical areas where the exchanges have provided data that have confirmed and aided US research and development efforts, impacted the design of the DWPF and guided the planning for regulatory interaction and product acceptance

  9. Activation of G Proteins by Guanine Nucleotide Exchange Factors Relies on GTPase Activity.

    Science.gov (United States)

    Stanley, Rob J; Thomas, Geraint M H

    2016-01-01

    G proteins are an important family of signalling molecules controlled by guanine nucleotide exchange and GTPase activity in what is commonly called an 'activation/inactivation cycle'. The molecular mechanism by which guanine nucleotide exchange factors (GEFs) catalyse the activation of monomeric G proteins is well-established, however the complete reversibility of this mechanism is often overlooked. Here, we use a theoretical approach to prove that GEFs are unable to positively control G protein systems at steady-state in the absence of GTPase activity. Instead, positive regulation of G proteins must be seen as a product of the competition between guanine nucleotide exchange and GTPase activity--emphasising a central role for GTPase activity beyond merely signal termination. We conclude that a more accurate description of the regulation of G proteins via these processes is as a 'balance/imbalance' mechanism. This result has implications for the understanding of intracellular signalling processes, and for experimental strategies that rely on modulating G protein systems.

  10. High temperature heat exchanger application in power engineering and energy-technological processes

    International Nuclear Information System (INIS)

    Shpilrain, E.E.

    1986-01-01

    The possibilities for intensification of various processes in metallurgy and chemical technology, the prospects for enhancing power plant efficiency are often linked with temperature increase of reagents, heat carriers and working fluids. In some cases elevated temperatures give the opportunity to use new and principally different technologies, enhance capacities of power production units and technological apparatuses, improve their economical performance. The variety of problems where high temperature heat exchangers are or can be used are extremely wide. It is therefore impossible to overview all of them in one lecture. Therefore the author tries to consider only some examples which are typical and gives an impression of what kind of problems arise in these cases

  11. Technology transfer and technological learning through CERN's procurement activity

    CERN Document Server

    Autio, Erkko; Hameri, Ari-Pekka; CERN. Geneva

    2003-01-01

    This report analyses the technological learning and innovation benefits derived from CERN's procurement activity during the period 1997-2001. The base population of our study, the technology-intensive suppliers to CERN, consisted of 629 companies out of 6806 companies during the same period, representing 1197 MCHF in procurement. The main findings from the study can be summarized as follows: the various learning and innovation benefits (e.g., technological learning, organizational capability development, market learning) tend to occur together. Learning and innovation benefits appear to be regulated by the quality of the supplier's relationship with CERN: the greater the amount of social capital built into the relationship, the greater the learning and innovation benefits. Regardless of relationship quality, virtually all suppliers derived significant marketing reference benefits from CERN. Many corollary benefits are associated with procurement activity. As an example, as many as 38% of the respondents devel...

  12. Semiautomatic exchanger of samples for carry out neutron activation analysis; Intercambiador semiautomatico de muestras para realizar analisis por activacion neutronica

    Energy Technology Data Exchange (ETDEWEB)

    Aguilar H, F.; Quintana C, G. [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico); Torres R, C. E.; Mejia J, J. O., E-mail: fortunato.aguilar@inin.gob.mx [Instituto Tecnologico de Toluca, Av. Tecnologico s/n, Ex-Rancho La Virgen, Metepec, Estado de Mexico (Mexico)

    2015-09-15

    In this paper the design methodology and implementation of a semiautomatic exchanger of samples for the Analysis Laboratory by Neutron Activation of the Reactor department is presented. Taking into account the antecedents, the necessities of improvement are described, as well as the equipment that previously contained the Laboratory. The project of the semiautomatic exchanger of samples was developed at Instituto Nacional de Investigaciones Nucleares, with its own technology to increase independence from commercial equipment. Each element of the semiautomatic exchanger of samples is described both in the design phase as construction. The achieved results are positive and encouraging for the fulfillment of the proposed objective that is to increase the capacity of the Laboratory. (Author)

  13. An Econometric Analysis of the Impact of Real Effective Exchange Rate on Economic Activities in Nepal

    OpenAIRE

    NARA BAHADUR THAPA

    2002-01-01

    This paper tests the relationship between REER and GDP on the Nepalese economy. In the literature, two channels of transmission exist for the real exchange rate to affect economic activities; these are the aggregate demand channel and the aggregate supply channel. The traditional view has it that the real exchange rate operates through the aggregate demand channel. This means that the depreciation of the real exchange rate enhances the international competitiveness of domestic goods, boosts n...

  14. The case for foreign exchange intervention: the government as an active reserve manager

    OpenAIRE

    Christopher J. Neely

    2005-01-01

    This paper argues that major governments should actively manage their foreign exchange portfolios to maximize the risk-adjusted return to the taxpayer by exploiting long-term, fundamental based predictability in floating exchange rates. Such transactions—equivalent to foreign exchange intervention—would improve welfare by transferring risk from private agents to the risk-tolerant government. Interventions explicitly designed to profit the reserve management authority would be more likely to b...

  15. A Novel RFID Sensing System Using Enhanced Surface Wave Technology for Battery Exchange Stations

    Directory of Open Access Journals (Sweden)

    Yeong-Lin Lai

    2014-01-01

    Full Text Available This paper presents a novel radio-frequency identification (RFID sensing system using enhanced surface wave technology for battery exchange stations (BESs of electric motorcycles. Ultrahigh-frequency (UHF RFID technology is utilized to automatically track and manage battery and user information without manual operation. The system includes readers, enhanced surface wave leaky cable antennas (ESWLCAs, coupling cable lines (CCLs, and small radiation patches (SRPs. The RFID sensing system overcomes the electromagnetic interference in the metallic environment of a BES cabinet. The developed RFID sensing system can effectively increase the efficiency of BES operation and promote the development of electric vehicles which solve the problem of air pollution as well as protect the environment of the Earth.

  16. Improvements on heavy water separation technology by isotopic water-hydrogen sulfide exchange

    International Nuclear Information System (INIS)

    Peculea, M.

    1987-01-01

    A series of possible variance is presented for the heavy water separation technology by isotopic H 2 O-H 2 S exchange at dual temperatures. The critical study of these variants, which are considered as characteristic quantities for the isotopes transport (production) and the extraction level is related to a dual temperature plant fed by liquid and cold column, which is the up-to-date technology employed in all heavy water production plants as variants of following plants are studied: dual temperature plant with double feeding; dual-temperature plant with equilibrium column (booster); dual-temperature-dual-pressure plant. Attention is paid to the variant with equilibration column (booster), executed and tested at the State Committee for Nuclear Energy and to the dual-temperature-dual pressure plant which presents the highest efficiency. (author)

  17. Technologic spin-off from CNEA's activities

    International Nuclear Information System (INIS)

    Belinco, Cesar G.

    2001-01-01

    An analysis is made of the spin-off of technology from the nuclear activities in Argentina. Several examples are mentioned in fields such as material sciences, non-destructive testing, forensic research, space activities, instrumentation as well as in environmental studies

  18. Technology Candidates for Air-to-Air and Air-to-Ground Data Exchange

    Science.gov (United States)

    Haynes, Brian D.

    2015-01-01

    Technology Candidates for Air-to-Air and Air-to-Ground Data Exchange is a two-year research effort to visualize the U. S. aviation industry at a point 50 years in the future, and to define potential communication solutions to meet those future data exchange needs. The research team, led by XCELAR, was tasked with identifying future National Airspace System (NAS) scenarios, determining requirements and functions (including gaps), investigating technical and business issues for air, ground, & air-to-ground interactions, and reporting on the results. The project was conducted under technical direction from NASA and in collaboration with XCELAR's partner, National Institute of Aerospace, and NASA technical representatives. Parallel efforts were initiated to define the information exchange functional needs of the future NAS, and specific communication link technologies to potentially serve those needs. Those efforts converged with the mapping of each identified future NAS function to potential enabling communication solutions; those solutions were then compared with, and ranked relative to, each other on a technical basis in a structured analysis process. The technical solutions emerging from that process were then assessed from a business case perspective to determine their viability from a real-world adoption and deployment standpoint. The results of that analysis produced a proposed set of future solutions and most promising candidate technologies. Gap analyses were conducted at two points in the process, the first examining technical factors, and the second as part of the business case analysis. In each case, no gaps or unmet needs were identified in applying the solutions evaluated to the requirements identified. The future communication solutions identified in the research comprise both specific link technologies and two enabling technologies that apply to most or all specific links. As a result, the research resulted in a new analysis approach, viewing the

  19. Robotics-Control Technology. Technology Learning Activity. Teacher Edition. Technology Education Series.

    Science.gov (United States)

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This document contains the materials required for presenting an 8-day competency-based technology learning activity (TLA) designed to introduce students in grades 6-10 to advances and career opportunities in the field of robotics-control technology. The guide uses hands-on exploratory experiences into which activities to help students develop…

  20. Benefits from an exchange of knowledge in the treaty-related science and technologies: A personal perspective

    International Nuclear Information System (INIS)

    Marshall, P.D.

    1999-01-01

    This paper describes benefits from an exchange of knowledge in the non-proliferation treaty related science and technologies concerning science and technology development. Benefits to State Parties are concerned with non-treaty uses of seismic, hydro acoustic, infrasound and radionuclides data, their evaluation and measuring techniques

  1. Technology, Incentives, or Both? Factors Related to Level of Hospital Health Information Exchange.

    Science.gov (United States)

    Lin, Sunny C; Everson, Jordan; Adler-Milstein, Julia

    2018-02-28

    To assess whether the level of health information exchange (HIE) in U.S. hospitals is related to technology capabilities, incentives to exchange, or both. A total of 1,812 hospitals attesting to stage 2 of Medicare's Meaningful Use Incentive Program through April 2016. Hospital-level, multivariate OLS regression with state fixed effects was used to analyze the relationship between technology capability and incentives measures, and percent of care transitions with summary of care records (SCRs) sent electronically to subsequent providers. Stage 2 hospitals reported sending SCRs electronically for an average of 41 percent (median = 33 percent) of transitions. HIE level is related to four capability measures, one incentive measure, and one measure that is related to both capability and incentive. Percent of transitions with SCRs sent electronically was 3 percentage points higher (95 percent CI: 0.1-5.1) for hospitals with a third-party HIE vendor, 3 percentage points higher (95 percent CI: 0.5-5.4) for hospitals with an EHR vendor as their HIE vendor, and 3 percentage points higher (95 percent CI: 0.4-5.4) for hospitals that automatically alert primary care providers. The direction and statistical significance of the relationships between specific EHR vendor and electronic SCR transmission level varied by vendor. Nonprofits and government hospitals performed 5 percentage points higher (95 percent CI: 1.5-9.1) and 8 percentage points higher (95 percent CI: 3.4-12.3) than for-profits. Hospitals in systems performed 3 percentage points higher (95 percent CI: 0.8-6.1). The overall level of HIE is low, with hospitals sending an SCR electronically for less than half of patient transitions. Specific hospital characteristics related to both technology capabilities and incentives were associated with higher levels of HIE. © Health Research and Educational Trust.

  2. Canadian Activities in Space Debris Mitigation Technologies

    Science.gov (United States)

    Nikanpour, Darius; Jiang, Xin Xiang; Goroshin, Samuel; Haddad, Emile; Kruzelecky, Roman; Hoa, Suong; Merle, Philippe; Kleiman, Jacob; Gendron, Stephane; Higgins, Andrew; Jamroz, Wes

    The space environment, and in particular the Low Earth Orbit (LEO), is becoming increasingly populated with space debris which include fragments of dysfunctional spacecraft parts and materials traveling at speeds up to 15 km per second. These pose an escalating potential threat to LEO spacecraft, the international space station, and manned missions. This paper presents the Canadian activities to address the concerns over space debris in terms of debris mitigation measures and technologies; these include novel spacecraft demise technologies to safely decommission the spacecraft at the end of the mission, integrated self-healing material technologies for spacecraft structures to facilitate self-repair and help maintain the spacecraft structural and thermal performance, hypervelocity ground test capability to predict the impact of space debris on spacecraft performance, and ways of raising awareness within the space community through participation in targeted Science and Technology conferences and international forums.

  3. Investing in International Information Exchange Activities to Improve the Safety, Cost Effectiveness and Schedule of Cleanup - 13281

    Energy Technology Data Exchange (ETDEWEB)

    Seed, Ian; James, Paula [Cogentus Consulting (United States); Mathieson, John [NDA United Kingdom (United Kingdom); Judd, Laurie [NuVision Engineering, Inc. (United States); Elmetti-Ramirez, Rosa; Han, Ana [US DOE (United States)

    2013-07-01

    With decreasing budgets and increasing pressure on completing cleanup missions as quickly, safely and cost-effectively as possible, there is significant benefit to be gained from collaboration and joint efforts between organizations facing similar issues. With this in mind, the US Department of Energy (DOE) and the UK Nuclear Decommissioning Authority (NDA) have formally agreed to share information on lessons learned on the development and application of new technologies and approaches to improve the safety, cost effectiveness and schedule of the cleanup legacy wastes. To facilitate information exchange a range of tools and methodologies were established. These included tacit knowledge exchange through facilitated meetings, conference calls and Site visits as well as explicit knowledge exchange through document sharing and newsletters. A DOE web-based portal has been established to capture these exchanges and add to them via discussion boards. The information exchange is operating at the Government-to-Government strategic level as well as at the Site Contractor level to address both technical and managerial topic areas. This effort has resulted in opening a dialogue and building working relationships. In some areas joint programs of work have been initiated thus saving resource and enabling the parties to leverage off one another activities. The potential benefits of high quality information exchange are significant, ranging from cost avoidance through identification of an approach to a problem that has been proven elsewhere to cost sharing and joint development of a new technology to address a common problem. The benefits in outcomes significantly outweigh the costs of the process. The applicability of the tools and methods along with the lessons learned regarding some key issues is of use to any organization that wants to improve value for money. In the waste management marketplace, there are a multitude of challenges being addressed by multiple organizations and

  4. Eddy current technology for heat exchanger and steam generator tube inspection

    Energy Technology Data Exchange (ETDEWEB)

    Obrutsky, L.; Lepine, B.; Lu, J.; Cassidy, R.; Carter, J. [Atomic Energy of Canada Limited, Chalk River, Ontario (Canada)

    2004-07-01

    A variety of degradation modes can affect the integrity of both heat exchanger (HX) and balance of plant tubing, resulting in expensive repairs, tube plugging or replacement of tube bundles. One key component for ensuring tube integrity is inspection and monitoring for detection and characterization of the degradation. In-service inspection of HX and balance of plant tubing is usually carried out using eddy current (EC) bobbin coils, which are adequate for the detection of volumetric degradations. However, detection and quantification of additional modes of degradation such as pitting, intergranular attack (IGA), axial cracking and circumferential cracking require specialized probes. The need for timely, reliable detection and characterization of these modes of degradation is especially critical in Nuclear Generating Stations. Transmit-receive single-pass array probes, developed by AECL, offer high defect detectability in conjunction with fast and reliable inspection capabilities. They have strong directional properties, permitting probe optimization for circumferential or axial crack detection. Compared to impedance probes, they offer improved performance in the presence of variable lift-off. This EC technology can help resolve critical detection issues at susceptible areas, such as the rolled-joint transitions at the tubesheet, U-bends and tube-support intersections. This paper provides an overview of the operating principles and the capabilities of advanced ET inspection technology available for HX tube inspection. Examples of recent application of this technology in Nuclear Generating Stations (NGSs) are discussed. (author)

  5. Eddy current technology for heat exchanger and steam generator tube inspection

    International Nuclear Information System (INIS)

    Obrutsky, L.; Lepine, B.; Lu, J.; Cassidy, R.; Carter, J.

    2004-01-01

    A variety of degradation modes can affect the integrity of both heat exchanger (HX) and balance of plant tubing, resulting in expensive repairs, tube plugging or replacement of tube bundles. One key component for ensuring tube integrity is inspection and monitoring for detection and characterization of the degradation. In-service inspection of HX and balance of plant tubing is usually carried out using eddy current (EC) bobbin coils, which are adequate for the detection of volumetric degradations. However, detection and quantification of additional modes of degradation such as pitting, intergranular attack (IGA), axial cracking and circumferential cracking require specialized probes. The need for timely, reliable detection and characterization of these modes of degradation is especially critical in Nuclear Generating Stations. Transmit-receive single-pass array probes, developed by AECL, offer high defect detectability in conjunction with fast and reliable inspection capabilities. They have strong directional properties, permitting probe optimization for circumferential or axial crack detection. Compared to impedance probes, they offer improved performance in the presence of variable lift-off. This EC technology can help resolve critical detection issues at susceptible areas, such as the rolled-joint transitions at the tubesheet, U-bends and tube-support intersections. This paper provides an overview of the operating principles and the capabilities of advanced ET inspection technology available for HX tube inspection. Examples of recent application of this technology in Nuclear Generating Stations (NGSs) are discussed. (author)

  6. The strategic use of standardized information exchange technology in a university health system.

    Science.gov (United States)

    Cheng, Po-Hsun; Chen, Heng-Shuen; Lai, Feipei; Lai, Jin-Shin

    2010-04-01

    This article illustrates a Web-based health information system that is comprised of specific information exchange standards related to health information for healthcare services in National Taiwan University Health System. Through multidisciplinary teamwork, medical and informatics experts collaborated and studied on system scope definition, standard selection challenges, system implementation barriers, system management outcomes, and further expandability of other systems. After user requirement analysis and prototyping, from 2005 to 2008, an online clinical decision support system with multiple functions of reminding and information push was implemented. It was to replace its original legacy systems and serve among the main hospital and three branches of 180-200 clinics and 7,500-8,000 patient visits per day. To evaluate the effectiveness of this system, user surveys were performed, which revealed that the average score of user satisfaction increased from 2.80 to 3.18 on a 4-point scale. Among the items, especially e-learning for training service, courtesy communications for system requests, and courtesy communications for system operations showed statistically significant improvement. From this study, the authors concluded that standardized information exchange technologies can be used to create a brand new enterprise value and steadily obtain more competitive advantages for a prestige healthcare system.

  7. HEALTH RECORDS AND INFORMATION TECHNOLOGY IN SUPPORT OF EXCHANGE OF HEALTH INFORMATION

    Directory of Open Access Journals (Sweden)

    Jordan Deliversky

    2017-05-01

    Full Text Available The exchange of health information in conditions directly related to electronic environment is referred as health information technology. Usually the protection of personal health related data is comprised of various elements such as ways of information usage and access to sensitive health information. The protection of individually identifiable health information is possible with combination of measures. Protective measures include administrative, technical and physical elements. Through such protective measures is possible to ensure confidentiality, integrity and availability of the information, while at the same time could be guaranteed the prevention of unauthorized access. Sensitive records usually contain personal health information. Personal medical data requires high level of protection, as its content includes medical condition or diagnosis, where unauthorized access could have negative impact on one’s personal and professional life.

  8. PEE-PEO block copolymer exchange rate between micelles is detergent and temperature activated

    Science.gov (United States)

    Schantz, Allen; Saboe, Patrick; Lee, Hee-Young; Sines, Ian; Butler, Paul; Bishop, Kyle; Maranas, Janna; Kumar, Manish

    We examine the kinetics of polymer chain exchange between polymer/detergent micelles, a system relevant to the synthesis of protein-containing biomimetic membranes. Although chain exchange between polymer aggregates in water is too slow to observe, adding detergent allows us to determine chain exchange rates using time-resolved small-angle neutron scattering (TR-SANS). We examine a membrane-protein-relevant, vesicle-forming ultra-short polymer, Poly(ethyl ethylene)20-Poly(ethylene oxide)18 (PEE20-PEO18). PEE20-PEO18 is solubilized in mixed micelles with the membrane-protein-compatible non-ionic detergent octyl- β -D-glucoside (OG). We show that OG activates block copolymer exchange, and obtain rate constants at two detergent concentrations above the CMC (critical micellar concentration) of OG. We find that chain exchange increases two orders of magnitude when temperature increases from 308 to 338 K, and that even a 1 mg/mL increase in OG concentration leads to a noticeable increase in exchange rate. We also calculate the activation energy for chain exchange and find that it is much higher than for lipid exchange. These findings explain the need for high detergent concentration and/or temperature to synthesize densely packed polymer/protein membranes.

  9. Values exchange: using online technology to raise awareness of values and ethics in radiography education.

    Science.gov (United States)

    Mc Inerney, John; Lees, Amanda

    2018-03-01

    Ethics and values are increasingly significant aspects of patient-centred healthcare. While it is widely agreed that ethics and values are essential for healthcare delivery, there is also an acknowledgement that these are areas that are challenging to teach. The purpose of this study is to report a small-scale evaluative research project of a web-based technology with the educational potential to facilitate learning in relation to ethics, values, self-reflection and peer-based learning. Five diagnostic radiography students took part in a semi-structured focus group with the aim of exploring their experiences of using Values Exchange, an online ethical decision-making framework, to examine practice-based ethical issues. Transcripts were interrogated for key themes. From the thematic analysis three major themes emerged, understanding and appreciating others, addressing the theory-practice gap and delivering a safe and effective learning environment. Perceived limitations of the platform included students' fear of misinterpreted responses and possibility of poor group dynamics. There are varied approaches to how ethics and values are taught and assessed within health-related environments. Values Exchange is one such teaching tool and has been investigated and described positively by radiography students in this study. Online teaching tools can have a positive effect in helping students identify their own values but require skilled implementation to reap positive rewards. © 2018 The Authors. Journal of Medical Radiation Sciences published by John Wiley & Sons Australia, Ltd on behalf of Australian Society of Medical Imaging and Radiation Therapy and New Zealand Institute of Medical Radiation Technology.

  10. Role of nonlocal exchange correlation in activated adsorption

    DEFF Research Database (Denmark)

    Hammer, Bjørk; Jacobsen, Karsten Wedel; Nørskov, Jens Kehlet

    1993-01-01

    The barrier for dissociative adsorption of H-2 on Al(110) has been calculated within the generalized gradient approximation. A pronounced increase of the barrier height is found compared with what is calculated in the local density approximation (LDA). The apparent LDA underestimation...... of the barrier height is shown to be intimately linked with the LDA underbinding of core electrons and we suggest it to be a general phenomenon not limited to the particular nonlocal exchange-correlation approximation used or the particular system studied....

  11. Technology development activities supporting tank waste remediation

    International Nuclear Information System (INIS)

    Bonner, W.F.; Beeman, G.H.

    1994-06-01

    This document summarizes work being conducted under the U.S. Department of Energy's Office of Technology Development (EM-50) in support of the Tank Waste Remediation System (TWRS) Program. The specific work activities are organized by the following categories: safety, characterization, retrieval, barriers, pretreatment, low-level waste, and high-level waste. In most cases, the activities presented here were identified as supporting tank remediation by EM-50 integrated program or integrated demonstration lead staff and the selections were further refined by contractor staff. Data sheets were prepared from DOE-HQ guidance to the field issued in September 1993. Activities were included if a significant portion of the work described provides technology potentially needed by TWRS; consequently, not all parts of each description necessarily support tank remediation

  12. Allosteric activation of sodium-calcium exchange by picomolar concentrations of cadmium.

    Science.gov (United States)

    Le, Hoa Dinh; Omelchenko, Alexander; Hryshko, Larry V; Uliyanova, Alexandra; Condrescu, Madalina; Reeves, John P

    2005-02-15

    Chinese hamster ovary cells expressing the bovine cardiac Na+-Ca2+ exchanger (NCX1.1) accumulated Cd2+ after a lag period of several tens of seconds. The lag period reflects the progressive allosteric activation of exchange activity by Cd2+ as it accumulates within the cytosol. The lag period was greatly reduced in cells expressing a mutant exchanger, Delta(241-680), that does not require allosteric activation by Ca2+ for activity. Non-transfected cells did not show Cd2+ uptake under the same conditions. In cells expressing NCX1.1, the lag period was nearly abolished following an elevation of the cytosolic Ca2+ concentration. Cytosolic Cd2+ concentrations estimated at 0.5-2 pm markedly stimulated the subsequent uptake of Ca2+ by Na+-Ca2+ exchange. Outward exchange currents in membrane patches from Xenopus oocytes expressing the canine NCX1.1 were rapidly and reversibly stimulated by 3 pm Cd2+ applied at the cytosolic membrane surface. Exchange currents activated by 3 pm Cd2+ were 40% smaller than currents activated by 1 mum cytosolic Ca2+. Current amplitudes declined by 30% and the rate of current development fell sharply upon repetitive applications of Na+ in the presence of 3 pm Cd2+. Cd2+ mimicked the anomalous inhibitory effects of Ca2+ on outward exchange currents generated by the Drosophila exchanger CALX1.1. We conclude that the regulatory sites responsible for allosteric Ca2+ activation bind Cd2+ with high affinity and that Cd2+ mimics the regulatory effects of Ca2+ at concentrations 5 orders of magnitude lower than Ca2+.

  13. Complete atrial-specific knockout of sodium-calcium exchange eliminates sinoatrial node pacemaker activity.

    Directory of Open Access Journals (Sweden)

    Sabine Groenke

    Full Text Available The origin of sinoatrial node (SAN pacemaker activity in the heart is controversial. The leading candidates are diastolic depolarization by "funny" current (If through HCN4 channels (the "Membrane Clock" hypothesis, depolarization by cardiac Na-Ca exchange (NCX1 in response to intracellular Ca cycling (the "Calcium Clock" hypothesis, and a combination of the two ("Coupled Clock". To address this controversy, we used Cre/loxP technology to generate atrial-specific NCX1 KO mice. NCX1 protein was undetectable in KO atrial tissue, including the SAN. Surface ECG and intracardiac electrograms showed no atrial depolarization and a slow junctional escape rhythm in KO that responded appropriately to β-adrenergic and muscarinic stimulation. Although KO atria were quiescent they could be stimulated by external pacing suggesting that electrical coupling between cells remained intact. Despite normal electrophysiological properties of If in isolated patch clamped KO SAN cells, pacemaker activity was absent. Recurring Ca sparks were present in all KO SAN cells, suggesting that Ca cycling persists but is uncoupled from the sarcolemma. We conclude that NCX1 is required for normal pacemaker activity in murine SAN.

  14. Information technology -- Telecommunications and information exchange between systems -- Local and metropolitan area networks -- Specific requirements -- Part 11: Wireless LAN Medium Access Control (MAC) and Physical Layer (PHY) specifications

    CERN Document Server

    International Organization for Standardization. Geneva

    1997-01-01

    Information technology -- Telecommunications and information exchange between systems -- Local and metropolitan area networks -- Specific requirements -- Part 11: Wireless LAN Medium Access Control (MAC) and Physical Layer (PHY) specifications

  15. Evaluation of a hybrid ion exchange-catalyst treatment technology for nitrate removal from drinking water.

    Science.gov (United States)

    Bergquist, Allison M; Choe, Jong Kwon; Strathmann, Timothy J; Werth, Charles J

    2016-06-01

    Ion exchange (IX) is the most common approach to treating nitrate-contaminated drinking water sources, but the cost of salt to make regeneration brine, as well as the cost and environmental burden of waste brine disposal, are major disadvantages. A hybrid ion exchange-catalyst treatment system, in which waste brine is catalytically treated for reuse, shows promise for reducing costs and environmental burdens of the conventional IX system. An IX model with separate treatment and regeneration cycles was developed, and ion selectivity coefficients for each cycle were separately calibrated by fitting experimental data. Of note, selectivity coefficients for the regeneration cycle required fitting the second treatment cycle after incomplete resin regeneration. The calibrated and validated model was used to simulate many cycles of treatment and regeneration using the hybrid system. Simulated waste brines and a real brine obtained from a California utility were also evaluated for catalytic nitrate treatment in a packed-bed, flow-through column with 0.5 wt%Pd-0.05 wt%In/activated carbon support (PdIn/AC). Consistent nitrate removal and no apparent catalyst deactivation were observed over 23 d (synthetic brine) and 45 d (real waste brine) of continuous-flow treatment. Ion exchange and catalyst results were used to evaluate treatment of 1 billion gallons of nitrate-contaminated source water at a 0.5 MGD water treatment plant. Switching from a conventional IX system with a two bed volume regeneration to a hybrid system with the same regeneration length and sequencing batch catalytic reactor treatment would save 76% in salt cost. The results suggest the hybrid system has the potential to address the disadvantages of a conventional IX treatment systems. Copyright © 2016 Elsevier Ltd. All rights reserved.

  16. Implication of remote technology for decontamination activities

    International Nuclear Information System (INIS)

    Kniazewycz, B.G.; Irving, J.T.; Long, D.C.; Wagoner, H.

    1986-01-01

    The use of robotics or remote technologies to remove man from hostile environments has long been a driving objective for technology development within the nuclear power industry. The Niagara Mohawk Power Corporation (NMPC) Nine Mile Point Nuclear Station is taking an organized approach to integrating remote technology into routine decontamination activities, non-processed radioactive waste disposal and special decontamination projects. Preliminary tests of an underwater robotic device for scrubbing and vacuuming was conducted at Nine Mile Point Unit 1 (NMP-1). The results of the test successfully provided proof of concept and identified improvements which would render the device acceptable for nuclear power station applications. Niagara Mohawk Power Corporation is undergoing a major radwaste retrofit project involving almost the entire Radwaste Building at NMP-1. The pre-demolition decontamination scenario was determined to be beneficial at reducing the project radiation exposure. Applications of remote technologies were identified to be cost beneficial for several project tasks including inspections, radiation survey mapping, debris sampling and removal, and video documentation. The purpose of this presentation is to discuss the remote technologies application program at Nine Mile Point and present in detail results of the projects mentioned

  17. The Analysis and Structuring of the Causes Impeding the Introduction of Advanced Technologies for Exchange Grain Trading

    Directory of Open Access Journals (Sweden)

    Vinnychenko Olena V

    2015-03-01

    Full Text Available In the article the main causes impeding the development and introduction of advanced technologies for grain trading on commodity exchanges in Ukraine have been identified and structured. The generalization of existing shortcomings in operation of the domestic commodity exchanges has served the basis for the model, within which there were built: a directed graph of correlations between the above mentioned shortcomings in the operation of exchanges, the matrix of dependency and reachability. The causes have been identified and structured, the main ones being determined, which, in turn, makes it possible to carry out the correct sequence of actions and emphasize the primary issues requiring priority solutions at making management decisions in order to promote the grain exchange market. The suggested approach clearly shows the correlation between the existing causes and sequence of their elimination.

  18. Natural clinoptilolite exchanged with iron: characterization and catalytic activity in nitrogen monoxide reduction

    Directory of Open Access Journals (Sweden)

    Daria Tito-Ferro

    2016-12-01

    Full Text Available The aim of this work was to characterize the natural clinoptilolite from Tasajeras deposit, Cuba, modified by hydrothermal ion-exchange with solutions of iron (II sulfate and iron (III nitrate in acid medium. Besides this, its catalytic activity to reduce nitrogen monoxide with carbon monoxide/propene in the presence of oxygen was evaluated. The characterization was performed by Mössbauer and UV-Vis diffuse reflectance spectroscopies and adsorption measurements. The obtained results lead to conclude that in exchanged samples, incorporated divalent and trivalent irons are found in octahedral coordination. Both irons should be mainly in cationic extra-framework positions inside clinoptilolite channels as charge compensating cations, and also as iron oxy-hydroxides resulting from limited hydrolysis of these cations. The iron (III exchanged samples has a larger amount of iron oxy-hydroxides agglomerates. The iron (II exchanged samples have additionally iron (II sulfate adsorbed. The catalytic activity in the nitrogen monoxide reduction is higher in the exchanged zeolites than starting. Among all samples, those exchanged of iron (II has the higher catalytic activity. This lead to outline that, main catalytically active centers are associated with divalent iron.

  19. Health information exchange technology on the front lines of healthcare: workflow factors and patterns of use

    Science.gov (United States)

    Johnson, Kevin B; Lorenzi, Nancy M

    2011-01-01

    Objective The goal of this study was to develop an in-depth understanding of how a health information exchange (HIE) fits into clinical workflow at multiple clinical sites. Materials and Methods The ethnographic qualitative study was conducted over a 9-month period in six emergency departments (ED) and eight ambulatory clinics in Memphis, Tennessee, USA. Data were collected using direct observation, informal interviews during observation, and formal semi-structured interviews. The authors observed for over 180 h, during which providers used the exchange 130 times. Results HIE-related workflow was modeled for each ED site and ambulatory clinic group and substantial site-to-site workflow differences were identified. Common patterns in HIE-related workflow were also identified across all sites, leading to the development of two role-based workflow models: nurse based and physician based. The workflow elements framework was applied to the two role-based patterns. An in-depth description was developed of how providers integrated HIE into existing clinical workflow, including prompts for HIE use. Discussion Workflow differed substantially among sites, but two general role-based HIE usage models were identified. Although providers used HIE to improve continuity of patient care, patient–provider trust played a significant role. Types of information retrieved related to roles, with nurses seeking to retrieve recent hospitalization data and more open-ended usage by nurse practitioners and physicians. User and role-specific customization to accommodate differences in workflow and information needs may increase the adoption and use of HIE. Conclusion Understanding end users' perspectives towards HIE technology is crucial to the long-term success of HIE. By applying qualitative methods, an in-depth understanding of HIE usage was developed. PMID:22003156

  20. Linking Employee Development Activity, Social Exchange and Organizational Citizenship Behavior

    Science.gov (United States)

    Pierce, Heather R.; Maurer, Todd J.

    2009-01-01

    The authors examined "perceived beneficiary" of employee development (self, organization) for relationships with employee development activity. Perceived organizational support served as a moderator. The authors conclude that employees may engage in development activities to partly benefit their organization to the extent that a positive exchange…

  1. Activation of the exchange factor Ras-GRF by calcium requires an intact Dbl homology domain.

    Science.gov (United States)

    Freshney, N W; Goonesekera, S D; Feig, L A

    1997-04-21

    Ras-GRF is a guanine nucleotide exchange factor that activates Ras proteins. Its activity on Ras in cells is enhanced upon calcium influx. Activation follows calcium-induced binding of calmodulin to an IQ motif near the N-terminus of Ras-GRF. Ras-GRF also contains a Dbl homology (DH) domain C-terminal to the IQ motif. In many proteins, DH domains act as exchange factors for Rho-GTPase family members. However, we failed to detect exchange activity of this domain on well characterized Rho family members. Instead, we found that mutations analogous to those that block exchange activity of Dbl prevented Ras-GRF activation by calcium/ calmodulin in vivo. All DH domains are followed immediately by a pleckstrin homology (PH) domain. We found that a mutation at a conserved site within the PH domain following the DH domain also prevented Ras-GRF activation by calcium in vivo. These results suggest that in addition to playing a role as activators of Rho proteins, DH domains can also contribute to the coupling of cellular signals to Ras activation.

  2. Guidance manual for conducting technology demonstration activities

    International Nuclear Information System (INIS)

    Jolley, R.L.; Morris, M.I.; Singh, S.P.N.

    1991-12-01

    This demonstration guidance manual has been prepared to assist Martin Marietta Energy Systems, Inc. (Energy Systems), staff in conducting demonstrations. It is prepared in checklist style to facilitate its use and assumes that Energy Systems personnel have project management responsibility. In addition to a detailed step-by-step listing of procedural considerations, a general checklist, logic flow diagram, and several examples of necessary plans are included to assist the user in developing an understanding of the many complex activities required to manage technology demonstrations. Demonstrations are pilot-scale applications of often innovative technologies to determine the commercial viability of the technologies to perform their designed function. Demonstrations are generally conducted on well-defined problems for which existing technologies or processes are less than satisfactory in terms of effectiveness, cost, and/or regulatory compliance. Critically important issues in demonstration management include, but are not limited to, such factors as communications with line and matrix management and with the US Department of Energy (DOE) and Energy Systems staff responsible for management oversight, budgetary and schedule requirements, regulatory compliance, and safety

  3. Guidance manual for conducting technology demonstration activities

    Energy Technology Data Exchange (ETDEWEB)

    Jolley, Robert L.; Morris, Michael I.; Singh, Suman P.N.

    1991-12-01

    This demonstration guidance manual has been prepared to assist Martin Marietta Energy Systems, Inc. (Energy Systems), staff in conducting demonstrations. It is prepared in checklist style to facilitate its use and assumes that Energy Systems personnel have project management responsibility. In addition to a detailed step-by-step listing of procedural considerations, a general checklist, logic flow diagram, and several examples of necessary plans are included to assist the user in developing an understanding of the many complex activities required to manage technology demonstrations. Demonstrations are pilot-scale applications of often innovative technologies to determine the commercial viability of the technologies to perform their designed function. Demonstrations are generally conducted on well-defined problems for which existing technologies or processes are less than satisfactory in terms of effectiveness, cost, and/or regulatory compliance. Critically important issues in demonstration management include, but are not limited to, such factors as communications with line and matrix management and with the US Department of Energy (DOE) and Energy Systems staff responsible for management oversight, budgetary and schedule requirements, regulatory compliance, and safety.

  4. Technology transfer in Activities Implemented Jointly (AIJ)

    Energy Technology Data Exchange (ETDEWEB)

    Usher, P.E.O. [United Nations Environment Programme (Cayman Islands)

    1998-08-01

    The agreed objective of the United Nations Framework Convention on Climate Change is to bring about early and significant reductions in greenhouse gas emissions. For many, the most attractive option for promoting this end is joint implementation. Indivisible from this is the transfer of current and innovative technology, though technology transfer is not conditional on joint implementation. The somewhat ad hoc nature of Activities Implemented Jointly (AIJ) and the failure to establish ground rules at the outset is considered. Common action can contribute to cost-effective mitigation of climate change through a sharing of the costs, benefits and risks of R and D, cross fertilisation of ideas among countries, economies of scale for new technologies, and clear signals to the international market. Potential problems include: the reluctance of national private industry to share proprietary information which might compromise competitiveness; premature convergence on technical standards that might inhibit the emergence of more developed technology; specific national circumstances which mean that solutions satisfactory to others are inappropriate in its case. This latter issue is of particular relevance to developing countries. AIJ needs to be approached in a systematic way taking into account lessons learned from evaluating the pilot phase if it is to be seen to be working effectively. (UK)

  5. Iridium(I)-catalyzed regioselective C-H activation and hydrogen-isotope exchange of non-aromatic unsaturated functionality.

    Science.gov (United States)

    Kerr, William J; Mudd, Richard J; Paterson, Laura C; Brown, Jack A

    2014-11-03

    Isotopic labelling is a key technology of increasing importance for the investigation of new CH activation and functionalization techniques, as well as in the construction of labelled molecules for use within both organic synthesis and drug discovery. Herein, we report for the first time selective iridium-catalyzed CH activation and hydrogen-isotope exchange at the β-position of unsaturated organic compounds. The use of our highly active [Ir(cod)(IMes)(PPh3 )][PF6 ] (cod=1,5-cyclooctadiene) catalyst, under mild reaction conditions, allows the regioselective β-activation and labelling of a range of α,β-unsaturated compounds with differing steric and electronic properties. This new process delivers high levels of isotope incorporation over short reaction times by using low levels of catalyst loading. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  6. Repository Technology Program activities, FY 1988

    International Nuclear Information System (INIS)

    Yow, J.L. Jr.; Wijesinghe, A.M.; Thorpe, R.K.; Knapp, R.B.

    1989-07-01

    Our technical activities in FY 1988 included instrument selection and evaluation, calculational work, and simulator development. Near the end of the fiscal year, we began preparing several topical reports to document our results. This fiscal year, we continued developing three-dimensional numerical simulators to model coupled hydrologic-and mechanical-rock mass responses and, thus, to provide representative numerical tools for understanding and calculating these in situ processes. We also began scoping calculations in the second half of FY 1988 to evaluate ERE design criteria, but this work was redirected late in the year when the DOE/AECL Subsidiary Agreement was set aside. Our work in developing and evaluating experimental techniques focused on total pressure measurements, moisture content measurement, and tracer detection instrumentation for sealing experiments and for rock-mass-response field tests. At the end of the fiscal year, we completed a review of measurement technology for instrumenting migration/sorption tests to help define the technological requirements in these areas. By the end of FY 1988, we had completed a review of the existing codes for simulating reactive transport; we are using the results of this review to help formulate plans for future activities in this area. The following sections describe the major RTP tasks and activities at LLNL in more detail, and they include our FY 1988 accomplishments in these areas. 8 refs., 22 figs

  7. Hydrogen water deuterium exchange studies on palladium on activated charcoal hydrophobic catalyst (Preprint No. CA-20)

    International Nuclear Information System (INIS)

    Dubey, Krishna; Malaikar, N.L.; Pushpangathan, C.K.

    1989-04-01

    Deuterium exchange between hydrogen gas and water is one of the most promising processes for heavy water production. In production of heavy water, separation factor and energy cost are two main parameters which govern the economic effectiveness of a process. Out of the chemical exchange process, H 2 -H 2 O exchange has higher separation factor at a given temperature. Even though the separation factor is high, major disadvantage in the process is that a catalyst is required. Group VIII metals are most suitable catalysts for hydrogenation, dehydrogenation and hydrogenolysis because of their ability to chemisorb H 2 dissociatively. Even among VIII2 triad, Pt has the highest activity. A highly active Pt catalyst has a reported half life of 4 seconds. As Pd is cheaper than Pt, studies have been carried out using active Pd as catalyst for H 2 -H 2 O exchange. It is observed that: (1)at metal concentration of 0.3%, Pd shows the optimum catalytic activity, (2)a highly active Pd is found to have a half life of 5 minutes, and (3)addition of α-alumina enhances the catalytic activity. (author). 6 refs., 5 figs

  8. Active heat exchange system development for latent heat thermal energy storage

    Science.gov (United States)

    Lefrois, R. T.; Mathur, A. K.

    1980-01-01

    Five tasks to select, design, fabricate, test and evaluate candidate active heat exchanger modules for future applications to solar and conventional utility power plants were discussed. Alternative mechanizations of active heat exchange concepts were analyzed for use with heat of fusion phase change materials (PCMs) in the temperature range of 250 to 350 C. Twenty-six heat exchange concepts were reviewed, and eight were selected for detailed assessment. Two candidates were selected for small-scale experimentation: a coated tube and shell heat exchanger and a direct contact reflux boiler. A dilute eutectic mixture of sodium nitrate and sodium hydroxide was selected as the PCM from over 50 candidate inorganic salt mixtures. Based on a salt screening process, eight major component salts were selected initially for further evaluation. The most attractive major components in the temperature range of 250 to 350 C appeared to be NaNO3, NaNO2, and NaOH. Sketches of the two active heat exchange concepts selected for test are given.

  9. Conformational analysis of Epac activation using amide hydrogen/deuterium exchange mass spectrometry.

    Science.gov (United States)

    Brock, Melissa; Fan, Fenghui; Mei, Fang C; Li, Sheng; Gessner, Christopher; Woods, Virgil L; Cheng, Xiaodong

    2007-11-02

    Exchange proteins directly activated by cAMP (Epac) play important roles in mediating the effects of cAMP through the activation of downstream small GTPases, Rap. To delineate the mechanism of Epac activation, we probed the conformation and structural dynamics of Epac using amide hydrogen/deuterium exchange and structural modeling. Our studies show that cAMP induces significant conformational changes that lead to a spatial rearrangement of the regulatory components of Epac and allows the exposure of the catalytic core for effector binding without imposing significant conformational change on the catalytic core. Homology modeling and comparative structural analyses of the cAMP binding domains of Epac and cAMP-dependent protein kinase (PKA) lead to a model of Epac activation, in which Epac and PKA activation by cAMP employs the same underlying principle, although the detailed structural and conformational changes associated with Epac and PKA activation are significantly different.

  10. Information exchange on HTGR and nuclear hydrogen technology between JAEA and INET in 2009

    International Nuclear Information System (INIS)

    Fujimoto, Nozomu; Wang Hong

    2010-07-01

    The worldwide interests in the HTGR (High Temperature Gas-cooled Reactor) have been growing because the high temperature heat produced by the reactor can be utilized not only for efficient power generation but also for broad process heat applications, especially for thermo-chemical hydrogen production to fuel a prospective hydrogen economy in future. Presently only two HTGR reactors are operational in the world, including the HTTR (High Temperature Engineering Test Reactor) in Japan Atomic Energy Agency (JAEA) and the HTR-10 in the Institute of Nuclear and New Energy Technology (INET) of Tsinghua University in China. JAEA and INET have cooperated since 1986 in the field of HTGR development, particularly on the HTTR and HTR-10 projects. This report describes the cooperation activities on HTGR and nuclear hydrogen technology between JAEA and INET in 2009. (author)

  11. Information exchange on HTGR and nuclear hydrogen technology between JAEA and INET in 2008

    International Nuclear Information System (INIS)

    Fujimoto, Nozomu; Tachibana, Yukio; Sun Yuliang

    2009-07-01

    The worldwide interests in the HTGR (High Temperature Gas-cooled Reactor) have been growing because the high temperature heat produced by the reactor can be utilized not only for efficient power generation but also for broad process heat applications, especially for thermo-chemical hydrogen production to fuel a prospective hydrogen economy in future. Presently only two HTGR reactors are operational in the world, including the HTTR (High Temperature Engineering Test Reactor) in Japan Atomic Energy Agency (JAEA) and the HTR-10 in the Institute of Nuclear and New Energy Technology (INET) of Tsinghua University in China. JAEA and INET have cooperated since 1986 in the field of HTGR development, particularly on the HTTR and HTR-10 projects. This report describes the cooperation activities on HTGR and nuclear hydrogen technology between JAEA and INET in 2008. (author)

  12. Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF.

    Science.gov (United States)

    Farnsworth, C L; Freshney, N W; Rosen, L B; Ghosh, A; Greenberg, M E; Feig, L A

    1995-08-10

    Tyrosine kinase receptors stimulate the Ras signalling pathway by enhancing the activity of the SOS nucleotide-exchange factor. This occurs, at least in part, by the recruitment of an SOS-GRB2 complex to Ras in the plasma membrane. Here we describe a different signalling pathway to Ras that involves activation of the Ras-GRF exchange factor in response to Ca2+ influx. In particular, we show that the ability of Ras-GRF to activate Ras in vivo is markedly enhanced by raised Ca2+ concentrations. Activation is mediated by calmodulin binding to an IQ motif in Ras-GRF, because substitutions in conserved amino acids in this motif prevent both calmodulin binding to Ras-GRF and Ras-GRF activation in vivo. So far, full-length Ras-GRF has been detected only in brain neurons. Our findings implicate Ras-GRF in the regulation of neuronal functions that are influenced by Ca2+ signals.

  13. The influence of activation of heterogeneous ion-exchange membranes on their electrochemical properties

    Czech Academy of Sciences Publication Activity Database

    Brožová, Libuše; Křivčík, J.; Neděla, D.; Kysela, V.; Žitka, Jan

    2015-01-01

    Roč. 56, č. 12 (2015), s. 3228-3232 ISSN 1944-3994. [International Conference on Membrane and Electromembrane Processes - MELPRO 2014. Prague, 18.05.2014-21.05.2014] Institutional support: RVO:61389013 Keywords : heterogeneous ion-exchange membranes * electrochemical properties * activation Subject RIV: JP - Industrial Processing Impact factor: 1.272, year: 2015

  14. Aluminum toxicity in tomato. Part 2.Leaf gas exchange, chlorophyll content, and invertase activity

    Science.gov (United States)

    L. Simon; M. Kieger; Shi-Jean S. Sung; T.J. Smalley

    1994-01-01

    The effect of aluminum (Al) toxicity on leaf gas exchange, leaf chlorophyll content, and sucrose metabolizing enzyme activity of two tomato cultivars (Lycopersicon esculentum Mill. 'Mountain Pride' and 'Floramerica') was studied to determine the mechanism of growth reduction observed in a related study (Simon et al., 1994, Part 1).Plants were grown...

  15. An Activity Theory Exegesis on Conflict and Contradictions in Networked Discussions and Feedback Exchanges

    Science.gov (United States)

    Hadjistassou, Stella K.

    2012-01-01

    The goal of this study was to investigate the culturally afforded contradictions that ten advanced English as a Second Language (ESL) learner encountered when they posted their paper topics and exchanged feedback strategies online and contextualized some of these strategies to draft their papers. Using Cultural-Historical Activity Theory (CHAT),…

  16. Amine-functionalized, silver-exchanged zeolite NaY: Preparation, characterization and antibacterial activity

    Energy Technology Data Exchange (ETDEWEB)

    Hanim, Siti Aishah Mohd; Malek, Nik Ahmad Nizam Nik, E-mail: niknizam@fbb.utm.my; Ibrahim, Zaharah

    2016-01-01

    Graphical abstract: - Highlights: • Functionalization of Ag-exchanged zeolite NaY with 3-aminopropyltriethoxysilane APTES (ZSA) as antibacterial agent. • Antibacterial assay of ZSA was performed against Escherichia coli ATCC11229 and Staphylococcus aureus ATCC6538. • Functionalization of Ag-exchanged zeolite NaY with APTES significantly increased the antibacterial agent. • Different mechanisms of bacterial death were suggested for each bacteria type by the functionalized Ag-exchanged zeolite NaY. - Abstract: Amine-functionalized, silver-exchanged zeolite NaY (ZSA) were prepared with three different concentrations of 3-aminopropyltriethoxysilane (APTES) (0.01, 0.20 and 0.40 M) and four different concentrations of silver ions (25%, 50%, 100% and 200% from zeolite cation exchange capacity (CEC)). The samples were characterized by Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), energy-dispersive X-ray (EDX), surface area analysis, thermogravimetric analysis (TGA) and zeta potential (ZP) analysis. The FTIR results indicated that the zeolite was functionalized by APTES and that the intensity of the peaks corresponding to APTES increased as the concentration of APTES used was increased. The antibacterial activities of the silver-exchanged zeolite NaY (ZS) and ZSA were studied against Escherichia coli ATCC11229 and Staphylococcus aureus ATCC6538 using the disc diffusion technique (DDT) and minimum inhibitory concentration (MIC). The antibacterial activity of ZSA increased with the increase in APTES on ZS, and E. coli was more susceptible towards the sample compared to S. aureus. The FESEM micrographs of the bacteria after contact with the ZSA suggested different mechanisms of bacterial death for these two bacteria due to exposure to the studied sample. The functionalization of ZS with APTES improved the antibacterial activity of the silver-zeolite, depending on the concentration of silver

  17. Ion Exchange Technology Development in Support of the Urine Processor Assembly Precipitation Prevention Project for the International Space Station

    Science.gov (United States)

    Mitchell, Julie L.; Broyan, James L.; Pickering, Karen D.; Adam, Niklas; Casteel, Michael; Callahan, Michael; Carrier, Chris

    2012-01-01

    In support of the Urine Processor Assembly Precipitation Prevention Project (UPA PPP), multiple technologies were explored to prevent CaSO4 2H2O (gypsum) precipitation during the on-orbit distillation process. Gypsum precipitation currently limits the water recovery rate onboard the International Space Station (ISS) to 70% versus the planned 85% target water recovery rate. Due to its ability to remove calcium cations in pretreated augmented urine (PTAU), ion exchange was selected as one of the technologies for further development by the PPP team. A total of 13 ion exchange resins were evaluated in various equilibrium and dynamic column tests with solutions of dissolved gypsum, urine ersatz, PTAU, and PTAU brine at 85% water recovery. While initial evaluations indicated that the Purolite SST60 resin had the highest calcium capacity in PTAU (0.30 meq/mL average), later tests showed that the Dowex G26 and Amberlite FPC12H resins had the highest capacity (0.5 meq/mL average). Testing at the Marshall Spaceflight Center (MSFC) integrates the ion exchange technology with a UPA ground article under flight-like pulsed flow conditions with PTAU. To date, no gypsum precipitation has taken place in any of the initial evaluations.

  18. Proceedings of the 1st JAEA/KAERI information exchange meeting on HTGR and nuclear hydrogen technology

    International Nuclear Information System (INIS)

    Sato, Hiroyuki; Sakaba, Nariaki; Nishihara, Tetsuo; Yan, Xing L.; Hino, Ryutaro

    2007-03-01

    Japan Atomic Energy Agency (JAEA) has completed an implementation with Korea Atomic Energy Research Institute (KAERI) on HTGR and nuclear hydrogen technology, 'The Implementation of Cooperative Program in the Field of Peaceful Uses of Nuclear Energy between KAERI and JAEA. 'To facilitate efficient technology development on HTGR and nuclear hydrogen by the IS process, an information exchange meeting was held at the Oarai Research and Development Center of JAEA on August 28-30, 2006 under Program 13th of the JAEA/KAERI Implementation, 'Development of HTGR and Nuclear Hydrogen Technology'. JAEA and KAERI mutually showed the status and future plan of the HTTR (High-Temperature Engineering Test Reactor) project in Japan and of the NHDD (Nuclear Hydrogen Development and Demonstration) project in Korea, respectively, and discussed collaboration items. This proceedings summarizes all materials of presented technical discussions on HTGR and hydrogen production technology as well as the meeting briefing including collaboration items. (author)

  19. Expectations and realities in the nuclear technology exchanges with the USSR

    Energy Technology Data Exchange (ETDEWEB)

    Lewin, J.

    1980-01-01

    A nontechnical, subjective account is given of some of the experiences and personal encounters in the US-USSR technical exchange visit programs. Some notes are given on the growth of nuclear power in the two countries. (DLC)

  20. International exchange project for the engineer exchange project (in coal mine technology area) in fiscal 1998. Overseas workshop; 1998 nendo gijutsusha koryu jigyo (tanko gijutsu bun'ya) kokusai koryu jigyo. Kaigai workshop

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    The international exchange project for the engineer exchange project (in coal mine technology area) in fiscal 1998, the 'Overseas workshop' has performed exchange in technologies with Australian coal mine engineers. The project refers to the Australian technological levels and needs in coal production, safety control and environment, as well as transfer of the Japanese coal mine technologies. This report summarizes the result of a survey on the engineer exchange project in the coal mine technology area and the possibility of joint researches. The 'overseas workshop' was held in November 1998 for two days in Brisbane City in QLD Province as the 'Japan-Australia coal technology workshop'. The 'Japan-Australia coal technology workshop' gave lectures in five sessions (the basic lecture, Japan-Australia high-speed excavation project, coal mine gas control project, exploration and resources, and development and experience of Japan). It also discussed two themes (mine safety management and rules, and greenhouse effect gases and coal mining). Two coal mines were visited thereafter to deepen the exchange with the Australian coal mine engineers. (NEDO)

  1. Activity systems modeling as a theoretical lens for social exchange studies

    Directory of Open Access Journals (Sweden)

    Ernest Jones

    2016-01-01

    Full Text Available The social exchange perspective seeks to acknowledge, understand and predict the dynamics of social interactions. Empirical research involving social exchange constructs have grown to be highly technical including confirmatory factor analysis to assess construct distinctiveness and structural equation modeling to assess construct causality. Each study seemingly strives to assess how underlying social exchange theoretic constructs interrelate. Yet despite this methodological depth and resultant explanatory and predictive power, a significant number of studies report findings that, once synthesized, suggest an underlying persistent threat of conceptual or construct validity brought about by a search for epistemological parsimony. Further, it is argued that a methodological approach that embraces inherent complexity such as activity systems modeling facilitates the search for simplified models while not ignoring contextual factors.

  2. The effect of monetary policy of Central Bank on activities of Tehran Stock Exchange

    Directory of Open Access Journals (Sweden)

    Hossein Vazifehdust

    2013-08-01

    Full Text Available This paper examines the relationship between monetary policy and activity of the Tehran Stock Exchange. The statistical population of the research consists of all companies listed in Tehran Stock Exchange and central bank monetary policy variables including time series generated by the central bank seasonally. For the purpose of data analysis, econometric autoregressive system models, and two-stage ADF regression with unit roots test, co-integration and reliability were used to determine level of effect and type of effect of the four components of monetary policy on exchange activity. The results of this study show that there is a strong relation between share price index and monetary policy variables and between monetary policy variables and trading volume. However, the relation between monetary policy variables and cash yield index was not so strong, but monetary policy variables’ effect on stock exchange activity was acceptable considering strong relation between the two first variables. It is suggested that if this work is done using non-linear models, it will yield better results.

  3. Antifungal activities against toxigenic Fusarium specie and deoxynivalenol adsorption capacity of ion-exchanged zeolites.

    Science.gov (United States)

    Savi, Geovana D; Cardoso, William A; Furtado, Bianca G; Bortolotto, Tiago; Zanoni, Elton T; Scussel, Rahisa; Rezende, Lucas F; Machado-de-Ávila, Ricardo A; Montedo, Oscar R K; Angioletto, Elidio

    2018-03-04

    Zeolites are often used as adsorbents materials and their loaded cations can be exchanged with metal ions in order to add antimicrobial properties. The aim of this study was to use the 4A zeolite and its derived ion-exchanged forms with Zn 2+ , Li + , Cu 2+ and Co 2+ in order to evaluate their antifungal properties against Fusarium graminearum, including their capacity in terms of metal ions release, conidia germination and the deoxynivalenol (DON) adsorption. The zeolites ion-exchanged with Li + , Cu 2+ , and Co 2+ showed an excellent antifungal activity against F. graminearum, using an agar diffusion method, with a zone of inhibition observed around the samples of 45.3 ± 0.6 mm, 25.7 ± 1.5 mm, and 24.7 ± 0.6 mm, respectively. Similar results using agar dilution method were found showing significant growth inhibition of F. graminearum for ion-exchanged zeolites with Zn 2+ , Li + , Cu 2+ , and Co 2+ . The fungi growth inhibition decreased as zeolite-Cu 2+ >zeolite-Li + >zeolite-Co 2+ >zeolite-Zn 2+ . In addition, the conidia germination was strongly affected by ion-exchanged zeolites. With regard to adsorption capacity, results indicate that only zeolite-Li + were capable of DON adsorption significantly (P concentration. The antifungal effects of the ion-exchanged zeolites can be ascribed to the interactions of the metal ions released from the zeolite structure, especially for zeolite-Li + , which showed to be a promising agent against F. graminearum and its toxin.

  4. Structural Dynamics Control Allosteric Activation of Cytohesin Family Arf GTPase Exchange Factors

    Energy Technology Data Exchange (ETDEWEB)

    Malaby, Andrew W.; Das, Sanchaita; Chakravarthy, Srinivas; Irving, Thomas C.; Bilsel, Osman; Lambright, David G.

    2018-01-01

    Membrane dynamic processes including vesicle biogenesis depend on Arf guanosine triphosphatase (GTPase) activation by guanine nucleotide exchange factors (GEFs) containing a catalytic Sec7 domain and a membrane-targeting module such as a pleckstrin homology (PH) domain. The catalytic output of cytohesin family Arf GEFs is controlled by autoinhibitory interactions that impede accessibility of the exchange site in the Sec7 domain. These restraints can be relieved through activator Arf-GTP binding to an allosteric site comprising the PH domain and proximal autoinhibitory elements (Sec7-PH linker and C-terminal helix). Small-angle X-ray scattering and negative-stain electron microscopy were used to investigate the structural organization and conformational dynamics of cytohesin-3 (Grp1) in autoinhibited and active states. The results support a model in which hinge dynamics in the autoinhibited state expose the activator site for Arf-GTP binding, while subsequent C-terminal helix unlatching and repositioning unleash conformational entropy in the Sec7-PH linker to drive exposure of the exchange site.

  5. Combined electrolysis and catalytic exchange (CECE) technology - an economical alternative for heavy water upgraders using water distillation

    International Nuclear Information System (INIS)

    Ryland, D.K.; Sadhankar, R.R.

    2003-01-01

    Heavy water upgrading is a unique and crucial part of a CANDU power station. Water distillation (DW) systems are used for heavy water upgrading in all CANDU stations. The DW upgrader is designed to take advantage of the difference in relative volatility (a measure of separation of isotopes) between H 2 O and D 2 O. However, the low relative volatility of the H 2 O/D 2 O system requires large number of stages (long columns) and large reflux ratios (large reboiler loads) - thus resulting in significant capital and operating costs. Atomic Energy of Canada Limited (AECL) developed the Combined Electrolysis and Catalytic Exchange (CECE) technology as an economical alternative to the DW system. CECE-based upgraders have been demonstrated in pilot scale facilities at AECL Chalk River Laboratories and in Hamilton, Ontario. This design is based on catalytic hydrogen isotope exchange between water and hydrogen gas. (author)

  6. Electron self-exchange activation parameters of diethyl sulfide and tetrahydrothiophene

    Directory of Open Access Journals (Sweden)

    Martin Goez

    2013-07-01

    Full Text Available Electron transfer between the title compounds and their radical cations, which were generated by photoinduced electron transfer from the sulfides to excited 2,4,6-triphenylpyrylium cations, was investigated by time-resolved measurements of chemically induced dynamic nuclear polarization (CIDNP in acetonitrile. The strongly negative activation entropies provide evidence for an associative–dissociative electron exchange involving dimeric radical cations. Despite this mechanistic complication, the free energies of activation were found to be well reproduced by the Marcus theory of electron transfer, with the activation barrier still dominated by solvent reorganization.

  7. Determinants of Foreign Technological Activity in German Regions

    DEFF Research Database (Denmark)

    Dettmann, Eva; Lacasa, Iciar Dominguez; Günther, Jutta

    that foreign technological activity more than doubled during the observation period with persistent spatial heterogeneity in Germany. Using a pooled count data model, we estimate the effect of various sources for externalities on the extent of foreign technological activity across regions. Our results show......This paper analyses the determinants of spatial distribution of foreign technological activity across 96 German regions (1996-2009). We identify foreign inventive activity by applying the ‘cross-border-ownership concept’ to transnational patent applications. The descriptive analysis shows...... that foreign technological activity is attracted by technologically specialised sectors of regions. In contrast to existing findings this effect applies both to foreign as well as domestic sources of specialisation. We show that the relation between specialization and foreign technological activity is non...

  8. An overview of heat exchanger technology in the Canadian nuclear program

    International Nuclear Information System (INIS)

    Carlucci, L.N.; Dalrymple, D.G.; Ko, P.L.; Pathania, R.; Pettigrew, M.I.; Scott, D.A.

    1981-06-01

    This paper provides an overview of the Canadian approach to the reliability and serviceability of heat exchange equipment used in nuclear power stations and heavy water plants. Current work in vibration and fretting predictions, thermal-hydraulic analyses, and corrosion research is described. Procedures developed for in-service inspection, in situ tube replacment and chemical cleaning of corrosion products are also outlined

  9. Gas exchange and antioxidant activity in seedlings of C opaifera langsdorffii Desf. under different water conditions

    OpenAIRE

    ROSA, DEREK B.C.J.; SCALON, SILVANA P.Q.; CREMON, THAIS; CECCON, FELIPE; DRESCH, DAIANE M.

    2017-01-01

    ABSTRACT The aim of this study was to evaluate gas exchange, efficiency of the photosynthetic apparatus, and antioxidant activity in Copaifera langsdorffii Desf. The seedlings were cultivated under different conditions of water availability, in order to improve the utilization efficiency of available water resources. The seedlings were cultivated in four different water retention capacities (WRC- 25%, 50%, 75%, and 100%), and evaluated at four different time (T- 30, 60, 90, and 120 days). Dur...

  10. Performance study of the TFTR diagnostic neutral beam for active charge exchange measurements

    International Nuclear Information System (INIS)

    Medley, S.S.; Goldston, R.J.; Towner, H.H.

    1980-06-01

    A neutral beam source will be incorporated in the Tokamak Fusion Test Reactor (TFTR) charge exchange diagnostic to provide a time modulated, spatially localized enhancement of the charge exchange efflux. Two autonomous Charge Exchange Neutral Analyzer (CENA) systems are being designed for the TFTR. One system measures the plasma ion temperature along twelve vertical line-of-sight chords spaced approximately equidistantly across the torus minor diameter. The other system is dedicated primarily to measurement of ion phenomena associated with neutral beam injection heating and has a fan-like field of view along eight sight-lines in the equitorial plane. The neutral beam is steerable in order to access the viewing field of both CENA systems, though in general not simultaneously. The performance of the diagnostic neutral beam is evaluated to determine the optimal beam specifications for active charge exchange measurements. Using the optimal beam design parameters, the efficacy of the neutral doping is examined for both CENA systems over the envisioned range of the TFTR plasma density and temperature

  11. More than just a question of technology: factors related to hospitals' adoption and implementation of health information exchange.

    Science.gov (United States)

    Vest, Joshua R

    2010-12-01

    The provisions of the American Recovery & Reinvestment Act increased the likelihood of more widespread health information exchange (HIE), the electronic transfer of patient-level information between organizations, by essentially mandating the use of electronic health record systems. While important, the sparse body of research on HIE efforts and anecdotal reports indicate the barriers to HIE adoption and implementation include factors beyond simply the presence or absence of a specific technology. This paper examines those technological, organizational, and environmental factors that are associated with both HIE adoption and implementation in a sample of 4830 U.S. hospitals. Factors associated with adoption and implementation were modeled using random-intercept logistic regression. Consistent with a perspective that adoption and implementation are different phenomena, many factors associated with an increased odds of adoption, were unassociated with implementation and vice versa. Non-profit status, public hospitals, more live and operation applications, more emergency room visits, network membership, and the presence of physician portals all increased hospitals' odds of HIE adoption. However, only network membership increased the odds of HIE implementation, whereas competition decreased those odds significantly. This study agreed with earlier case-studies and anecdotal reports that factors beyond technology were important to both adoption and implementation. While current U.S. policy on healthcare information technology adoption focuses on technological barriers, many other non-technological factors may ultimately hinder effective HIE. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

  12. Amine-functionalized, silver-exchanged zeolite NaY: Preparation, characterization and antibacterial activity

    Science.gov (United States)

    Hanim, Siti Aishah Mohd; Malek, Nik Ahmad Nizam Nik; Ibrahim, Zaharah

    2016-01-01

    Amine-functionalized, silver-exchanged zeolite NaY (ZSA) were prepared with three different concentrations of 3-aminopropyltriethoxysilane (APTES) (0.01, 0.20 and 0.40 M) and four different concentrations of silver ions (25%, 50%, 100% and 200% from zeolite cation exchange capacity (CEC)). The samples were characterized by Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), energy-dispersive X-ray (EDX), surface area analysis, thermogravimetric analysis (TGA) and zeta potential (ZP) analysis. The FTIR results indicated that the zeolite was functionalized by APTES and that the intensity of the peaks corresponding to APTES increased as the concentration of APTES used was increased. The antibacterial activities of the silver-exchanged zeolite NaY (ZS) and ZSA were studied against Escherichia coli ATCC11229 and Staphylococcus aureus ATCC6538 using the disc diffusion technique (DDT) and minimum inhibitory concentration (MIC). The antibacterial activity of ZSA increased with the increase in APTES on ZS, and E. coli was more susceptible towards the sample compared to S. aureus. The FESEM micrographs of the bacteria after contact with the ZSA suggested different mechanisms of bacterial death for these two bacteria due to exposure to the studied sample. The functionalization of ZS with APTES improved the antibacterial activity of the silver-zeolite, depending on the concentration of silver ions and APTES used during modification.

  13. The future of technology enhanced active learning – a roadmap

    OpenAIRE

    Pahl, Claus; Kenny, Claire

    2008-01-01

    The notion of active learning refers to the active involvement of learner in the learning process, capturing ideas of learning-by-doing and the fact that active participation and knowledge construction leads to deeper and more sustained learning. Interactivity, in particular learnercontent interaction, is a central aspect of technology-enhanced active learning. In this roadmap, the pedagogical background is discussed, the essential dimensions of technology-enhanced active learning syste...

  14. Indoor Levels of Formaldehyde and Other Pollutants and Relationship to Air Exchange Rates and Human Activities

    Science.gov (United States)

    Huangfu, Y.; O'Keeffe, P.; Kirk, M.; Walden, V. P.; Lamb, B. K.; Jobson, B. T.

    2017-12-01

    This paper reports results on an indoor air quality study conducted on six homes in summer and winter, contrasting indoor and outdoor concentrations of O3, CO, CO2, NOx, PM2.5, and selected volatile organic hydrocarbons measured by PTR-MS. Data were collected as 1 minute averages. Air exchange rates of the homes were determined by CO2 tracer release. Smart home sensors, recording human activity level in various places in the home, and window and doors openings, were utilized to better understand the link between human activity and indoor air pollution. From our study, averaged air exchange rates of the homes ranged from 0.2 to 1.2 hour-1 and were greatly affected by the ventilation system type and window and door openings. In general, a negative correlation between air exchange rate and indoor VOCs levels was observed, with large variation of pollutant levels between the homes. For most of the VOCs measured in the house, including formaldehyde and acetaldehyde, summer levels were much higher than winter levels. In some homes formaldehyde levels displayed a time of day variation that was linked to changes in indoor temperature. During a wildfire period in the summer of 2015, outdoor levels of PM2.5, formaldehyde, and benzene dramatically increased, significantly impacting indoor levels due to infiltration. Human activities, such as cooking, can significantly change the levels of most of the compounds measured in the house and the levels can be significantly elevated for short periods of time, with peak levels can be several orders higher compared with typical levels. The data suggest that an outcome of state energy codes that require new homes to be energy efficient, and as a consequence built with lower air exchange rates, will be unacceptable levels of air toxics, notably formaldehyde.

  15. Role of Subunit Exchange and Electrostatic Interactions on the Chaperone Activity of Mycobacterium leprae HSP18.

    Science.gov (United States)

    Nandi, Sandip Kumar; Panda, Alok Kumar; Chakraborty, Ayon; Sinha Ray, Sougata; Biswas, Ashis

    2015-01-01

    Mycobacterium leprae HSP18, a major immunodominant antigen of M. leprae pathogen, is a small heat shock protein. Previously, we reported that HSP18 is a molecular chaperone that prevents aggregation of different chemically and thermally stressed client proteins and assists refolding of denatured enzyme at normal temperature. We also demonstrated that it can efficiently prevent the thermal killing of E. coli at higher temperature. However, molecular mechanism behind the chaperone function of HSP18 is still unclear. Therefore, we studied the structure and chaperone function of HSP18 at normal temperature (25°C) as well as at higher temperatures (31-43°C). Our study revealed that the chaperone function of HSP18 is enhanced significantly with increasing temperature. Far- and near-UV CD experiments suggested that its secondary and tertiary structure remain intact in this temperature range (25-43°C). Besides, temperature has no effect on the static oligomeric size of this protein. Subunit exchange study demonstrated that subunits of HSP18 exchange at 25°C with a rate constant of 0.018 min(-1). Both rate of subunit exchange and chaperone activity of HSP18 is found to increase with rise in temperature. However, the surface hydrophobicity of HSP18 decreases markedly upon heating and has no correlation with its chaperone function in this temperature range. Furthermore, we observed that HSP18 exhibits diminished chaperone function in the presence of NaCl at 25°C. At elevated temperatures, weakening of interactions between HSP18 and stressed client proteins in the presence of NaCl results in greater reduction of its chaperone function. The oligomeric size, rate of subunit exchange and structural stability of HSP18 were also found to decrease when electrostatic interactions were weakened. These results clearly indicated that subunit exchange and electrostatic interactions play a major role in the chaperone function of HSP18.

  16. Enhancement of international cooperation and experience exchange: international and regional cooperation in nuclear technology

    International Nuclear Information System (INIS)

    Henderson, R.R.

    1987-01-01

    This paper will explore methods that have been effective in accomplishing broad-based technology transfer relationships between international commercial nuclear organizations, and have enhanced the benefits from such relationships through mutual participation in the development of new technology. The factors involved in accomplishing technology transfer will be examined based on the 25 years of Westinghouse experience in establishing successful nuclear technology relationships with over 20 different associates world-wide. This will include information pertaining to organization, training, consultation, technical information transmission, and other important aspects of technology transfer. Additionally, the methodology of enhancing and increasing the benefits of technology transfer through cooperative development programs as produced and promoted by Weatinghouse with its associates will be examined. This will include reviews of several significant copperative programs, such as the programs for the Advanced Pressurized Water Reactor and the Integrated Protection and Control Systems for future plants. (author)

  17. Enhancement of international cooperation and experience exchange - international and regional cooperation in nuclear technology

    International Nuclear Information System (INIS)

    Henderson, R.R.

    1988-01-01

    This paper will explore methods that have been effective in accomplishing broad-based technology transfer relationships between international commercial nuclear organizations, and have enhanced the benefits from such relationships through mutual participation in the development of new technology. The factors involved in accomplishing technology transfer will be examined based on the 25 years of Westinghouse experience in establishing successful nuclear technology relationships with over 20 different associates world-wide. This will include information pertaining to organization, training, consultation, technical information transmission, and other important aspects of technology transfer. Additionally, the methodology of enhancing and increasing the benefits of technology transfer through cooperative development programs as produced and promoted by Westinghouse with its associates will be examined. This will include reviews of several significant cooperative programs, such as the programs for the Advanced Pressurized Water Reactor and the Integrated Protection and Control Systems for future plants

  18. Project to promote exchange of international information on environmental technologies; Kankyo gijutsu kokusai joho koryu sokushin jigyo

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    Mutual information exchange at international levels is important for practical application of global environment preservation technologies, whereas the APEC Virtual Center was established in fiscal 1997. Fiscal 1998 has discussed the future functions of the Virtual Center, and carried out the following matters to improve the functions and achieve its stable operation. Discussions were given on common use with the centers of other countries and regions of the specifications of classification systems for information areas and provided information that are provided by the Virtual Center. Visits were made to sub-managing countries and regions for smooth operation of the study groups, and opinions were exchanged. Visits were made to coordinators and contact points established in each country and region when the Center was founded in fiscal 1997. A visit was made to the U.S. Environmental Protection Agency to exchange opinions on coordination measures with the Cleaner Production Strategy of the U.S.A. being a project similar to the subject project. In order to strengthen the Japan's Center, attempts were made to expand the linking information to wider scope. Special pages publishing concentratedly the items of information that the users are interested were prepared as part of the information provision. (NEDO)

  19. Rapid exchange ultra-thin microcatheter using fibre-optic sensing technology for measurement of intracoronary fractional flow reserve.

    Science.gov (United States)

    Diletti, Roberto; Van Mieghem, Nicolas M; Valgimigli, Marco; Karanasos, Antonis; Everaert, Bert R C; Daemen, Joost; van Geuns, Robert-Jan; de Jaegere, Peter P; Zijlstra, Felix; Regar, Evelyn

    2015-08-01

    The present report describes a novel coronary fractional flow reserve (FFR) system which allows FFR assessment using a rapid exchange microcatheter (RXi). The RXi microcatheter is compatible with standard 0.014" coronary guidewires facilitating lesion negotiation and FFR assessment in a wide range of coronary anatomies. In case of serial lesions, a microcatheter would have the important advantage of allowing multiple pullbacks while maintaining wire access to the vessel. The RXi is a fibre-optic sensor technology-based device. This technology might allow reduction in signal drift. The RXi microcatheter's fibre-optic sensor is located 5 mm from the distal tip. The microcatheter profile at the sensor site is 0.027"0.036". The segment of the catheter which is intended to reside within the target lesion is proximal to the sensor and has dimensions decreased to 0.020"0.025"; these dimensions are comparable to a 0.022" circular-shaped wire. The RXi microcatheter FFR system represents a novel technology that could allow easier lesion negotiation, maintaining guidewire position, facilitating pullbacks for assessment of serial lesions and simplifying the obtainment of post-intervention FFR measurements. The optical sensing technology could additionally result in less signal drift. Further investigations are required to evaluate the clinical value of this technology fully.

  20. Evaluating Efficiency of Tehran Stock Exchange: Case Study for Top Fifty Most Active Companies (TSE-50

    Directory of Open Access Journals (Sweden)

    Reza TALEBLOO

    2014-12-01

    Full Text Available Economics of information has been developing increasingly in economics literature in recent decades. Accordingly, the information plays a crucial role in efficiency of any market particularly capital market which deals more with this issue. As for the importance of information in stock exchange efficiency, the market efficiency is studied under three data sets in three forms including: 1- Information concerning the past prices, 2- All the released information and, 3- General Information and Confidential private information. Given these three types of information, market efficiency is checked in three weak, semi-strong and strong levels, respectively. This paper in order to examine the efficiency in the weak level employs a decomposed pattern with two stochastic and random terms for Top Fifty most active companies (TSE-50 in Tehran stock exchange based on both long and short horizons. The findings demonstrate that the indicator does not have efficiency in long horizon. This is while; the efficiency is verified in short horizon.

  1. Active atmosphere-ecosystem exchange of the vast majority of detected volatile organic compounds.

    Science.gov (United States)

    Park, J-H; Goldstein, A H; Timkovsky, J; Fares, S; Weber, R; Karlik, J; Holzinger, R

    2013-08-09

    Numerous volatile organic compounds (VOCs) exist in Earth's atmosphere, most of which originate from biogenic emissions. Despite VOCs' critical role in tropospheric chemistry, studies for evaluating their atmosphere-ecosystem exchange (emission and deposition) have been limited to a few dominant compounds owing to a lack of appropriate measurement techniques. Using a high-mass resolution proton transfer reaction-time of flight-mass spectrometer and an absolute value eddy-covariance method, we directly measured 186 organic ions with net deposition, and 494 that have bidirectional flux. This observation of active atmosphere-ecosystem exchange of the vast majority of detected VOCs poses a challenge to current emission, air quality, and global climate models, which do not account for this extremely large range of compounds. This observation also provides new insight for understanding the atmospheric VOC budget.

  2. Functional exchange of components between light-activated photoreceptor phosphodiesterase and hormone-activated adenylate cyclase systems

    Energy Technology Data Exchange (ETDEWEB)

    Bitensky, M.W.; Wheeler, M.A.; Rasenick, M.M.; Yamazaki, A.; Stein, P.J.; Halliday, K.R.; Wheeler, G.L.

    1982-06-01

    Previous studies have noted profound similarities between the regulation of light-activated (3',5'-cyclic-nucleotide 5'-nucleotidohydrolase, EC 3.1.4.17) in retinal rods and hormone-activated adenylate cyclase (ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1) in a variety of tissues. We report ere the functional exchange of components isolated from the photoreceptor system, which displayed predicted functional characteristics when incubated with recipient adenylate cyclase systems from rat cerebral cortical and hypothalamic synaptic membranes and frog erythrocyte ghosts. We demonstrate functional exchange of photoreceptor components at each of three loci: the hormone receptor, the GTP-binding protein (GBP), and the catalytic moiety of adenylate cyclase. Illuminated (but not unilluminated) rhodopsin was found to mimic the hormone-receptor complex, causing GTP-dependent activation of adenylate cyclase. The photoreceptor GBP complexed with guanosine 5'-(..beta..,..gamma..)imidotriphosphate (p(NH)ppG) produced a marked activation of recipient adenylate cyclase systems. Much smaller activation was observed when GBP was not complexed with p(NH)ppG. A heat-stable photoreceptor phosphodiesterase inhibitor reduced both basal and Mn/sup 2 +/-activated adenylate cyclase activites and this inhibition was reversed by photoreceptor GBPp(NH)ppG. These data demonstrate a remarkable functional compatibility between subunits of both systems and furthermore imply that specialized peptide domains responsible for protein-protein interactions are highly conserved.

  3. Ion Exchange Technology Development in Support of the Urine Processor Assembly

    Science.gov (United States)

    Mitchell, Julie; Broyan, James; Pickering, Karen

    2013-01-01

    The urine processor assembly (UPA) on the International Space Station (ISS) recovers water from urine via a vacuum distillation process. The distillation occurs in a rotating distillation assembly (DA) where the urine is heated and subjected to sub-ambient pressure. As water is removed, the original organics, salts, and minerals in the urine become more concentrated and result in urine brine. Eventually, water removal will concentrate the urine brine to super saturation of individual constituents, and precipitation occurs. Under typical UPA DA operating conditions, calcium sulfate or gypsum is the first chemical to precipitate in substantial quantity. During preflight testing with ground urine, the UPA achieved 85% water recovery without precipitation. However, on ISS, it is possible that crewmember urine can be significantly more concentrated relative to urine from ground donors. As a result, gypsum precipitated in the DA when operating at water recovery rates at or near 85%, causing the failure and subsequent re14 NASA Tech Briefs, September 2013 placement of the DA. Later investigations have demonstrated that an excess of calcium and sulfate will cause precipitation at water recovery rates greater than 70%. The source of the excess calcium is likely physiological in nature, via crewmembers' bone loss, while the excess sulfate is primarily due to the sulfuric acid component of the urine pretreatment. To prevent gypsum precipitation in the UPA, the Precipitation Prevention Project (PPP) team has focused on removing the calcium ion from pretreated urine, using ion exchange resins as calcium removal agents. The selectivity and effectiveness of ion exchange resins are determined by such factors as the mobility of the liquid phase through the polymer matrix, the density of functional groups, type of functional groups bound to the matrix, and the chemical characteristics of the liquid phase (pH, oxidation potential, and ionic strength). Previous experience with ion

  4. Canadian Fusion Fuels Technology Project activities report

    International Nuclear Information System (INIS)

    1985-01-01

    The Canadian Fusion Fuels Technology Project was formally established in 1982. The project is directed toward the further development of Canadian capabilities in five major areas: tritium technology, breeder technology, materials technology, equipment development and safety and the environment. The project is funded by three partners - Government of Canada (50%), Ontario Provincial Government (25%) and Ontario Hydro (25%). The fiscal year 1984/85 represents the third year of operation of the project. In 1984/85, 108 contracts were awarded totalling $4 million. Supplementary funding by subcontractors added approximately $1.9 million to the total project value. More than 200 people participated in the technical work involved in the project. Sixteen people were on attachment to foreign facilities for terms ranging from 1 month to 2.5 years. Five patents were applied for including a tritium discrimination monitor, a new radio-chemical tritium separation method, a new variation of fuel cleanup by gas chromatography, a passive tritium permeation system using bimetallic membranes, and a new breeder process using lithium salts dissolved in heavy water

  5. Designing Technology Activities that Teach Mathematics

    Science.gov (United States)

    Silk, Eli M.; Higashi, Ross; Shoop, Robin; Schunn, Christian D.

    2010-01-01

    Over the past three years, the authors have conducted research in middle and high school classrooms in an effort to improve the effectiveness of robotics to teach science, technology, engineering, and mathematics (STEM) education--their focus has been on math. The authors have found that subtle changes in the design and setup of the lesson make a…

  6. Technology of remote monitoring for nuclear activity monitoring

    International Nuclear Information System (INIS)

    Kwack, Ehn Ho; Kim, Jong Soo; Yoon, Wan Ki; Park, Sung Sik; Na, Won Woo; An, Jin Soo; Cha, Hong Ryul; Kim, Jung Soo

    2000-05-01

    In a view of safeguards monitoring at nuclear facilities, the monitoring is changing to remote method so that this report is described to remote monitoring(RM) applying on commercial NPP in Korea. To enhance IAEA safeguards efficiency and effectiveness, IAEA is taking into account of remote monitoring system(RMS) and testing as a field trial. IRMP(International Remote Monitoring Project) in participating many nations for development of RMS is proceeding their project such as technical exchange and research etc. In case of our country are carrying out the research relevant RM since acceptance RMS at 7th ROK-IAEA safeguards implementation review meeting. With a view to enhancement the RMS, installation location and element technology of the RM equipment are evaluated in a view of safeguards in Korea LWRs, and proposed a procedure for national inspection application through remote data evaluation from Younggwang-3 NPP. These results are large valuable to use of national inspection at time point extending installation to all Korea PWR NPP. In case of CANDU, neutron, gamma measurement and basic concept of network using optical fiber scintillating detector as remote verification method for dry storage canister are described. Also RM basic design of spent fuel transfer campaign is described that unattended RM without inspector instead of performing in participating together with IAEA and national inspector. The transfer campaign means the spent fuel storage pond to dry storage canister for about two months every year. Therefore, positively participation of IAEA strength safeguards project will be increased transparency for our nuclear activity as well as contributed to national relevant industry

  7. Ideas Exchange: "How Important Is Activity in Young Children (Preschool) to a Lifetime of Physical Activity?"

    Science.gov (United States)

    Hushman, GLenn; Morrison, Jaime; Mally, Kristi; McCall, Renee; Corso, Marjorie; Kamla, Jim; Magnotta, John; Chase, Melissa A.; Garrahy, Deborah A.; Lorenzi, David G.; Barnd, Sue

    2009-01-01

    This article presents the opinions of several professionals who were asked: "How important is activity in young children (preschool) to a lifetime of physical activity?" These professionals point out the importance of physical activity to young children.

  8. High temperature technological heat exchangers and steam generators with helical coil assembly tube bundle

    International Nuclear Information System (INIS)

    Korotaev, O.J.; Mizonov, N.V.; Nikolaevsky, V.B.; Nazarov, E.K.

    1990-01-01

    Analysis of thermal hydraulics characteristics of nuclear steam generators with different tube bundle arrangements and waste heat boilers for ammonia production units was performed on the basis of operating experience results and research and development data. The present report involves the obtained information. The estimations of steam generator performances and repair-ability are given. The significant temperature profile of the primary and secondary coolant flows are attributed to all steam generator designs. The intermediate mixing is found to be an effective means of temperature profile overcoming. At present the only means to provide an effective mixing in heat exchangers of the following types: straight tubes, field tubes, platen tubes and multibank helical coil tubes (with complicated bend distribution along their length) are section arrangements in series in conjunction with forced and natural mixing in connecting lines. Development of the unificated system from mini helical coil assemblies allows to design and manufacture heat exchangers and steam generators within the wide range of operating conditions without additional expenses on the research and development work

  9. Activating Technology for Connected Health in Cancer

    DEFF Research Database (Denmark)

    Mountford, Nicola; Dorronzoro Zubiete, Enrique; Kessie, Threase

    2018-01-01

    a sustainable approach to cancer survivor reintegration using technology. METHODS: The program, funded under the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 722012, includes deep disciplinary PhD projects, intersectoral and international......BACKGROUND: As cancer survival rates increase, the challenge of ensuring that cancer survivors reclaim their quality of life (QoL) becomes more important. This paper outlines the research element of a research and training program that is designed to do just that. OBJECTIVE: Bridging sectors......, disciplines, and geographies, it brings together eight PhD projects and students from across Europe to identify the underlying barriers, test different technology-enabled rehabilitative approaches, propose a model to optimize the patient pathways, and examine the business models that might underpin...

  10. MLS student active learning within a "cloud" technology program.

    Science.gov (United States)

    Tille, Patricia M; Hall, Heather

    2011-01-01

    In November 2009, the MLS program in a large public university serving a geographically large, sparsely populated state instituted an initiative for the integration of technology enhanced teaching and learning within the curriculum. This paper is intended to provide an introduction to the system requirements and sample instructional exercises used to create an active learning technology-based classroom. Discussion includes the following: 1.) define active learning and the essential components, 2.) summarize teaching methods, technology and exercises utilized within a "cloud" technology program, 3.) describe a "cloud" enhanced classroom and programming 4.) identify active learning tools and exercises that can be implemented into laboratory science programs, and 5.) describe the evaluation and assessment of curriculum changes and student outcomes. The integration of technology in the MLS program is a continual process and is intended to provide student-driven active learning experiences.

  11. NOx reduction over metal-ion exchanged novel zeolite under lean conditions. Activity and hydrothermal stability

    International Nuclear Information System (INIS)

    Subbiah, Ayyappan; Gujar, Amit; Price, Geoffrey L.; Cho, Byong K.; Blint, Richard J.; Yie, Jae E.

    2003-01-01

    Zeolite SUZ-4 was synthesized and tested for its hydrothermal stability using a standard aging procedure coupled with NMR spectroscopy, and was identified as a promising support for lean-NO x catalysts for high temperature applications. Various metals such as Cu, Ag, Fe, Co were ion exchanged onto the SUZ-4 zeolite, and their catalytic activity for NO/NO x conversion was measured in the presence of excess oxygen using ethylene as the reducing agent. Among the metal-ions exchanged, copper proved to be the best metal cation for lean-NO x catalysis with the optimum level of exchange at 29-42%. The optimized, fresh Cu/SUZ-4 catalyst achieved 70-80% of NO/NO x conversion activity over a wide range of temperature from 350 to 600C with the maximum conversion temperature at 450C. The presence of H 2 O and SO 2 reduced the NO/NO x conversion by about 30% of the fresh Cu/SUZ-4 catalyst due possibly to the blocking of active sites for NO/NO x adsorption. Substitution of gasoline vapor for ethylene as the reductant improved the NO x reduction activity of the fresh Cu/SUZ-4 catalyst at high temperatures above 350C. Aging the Cu/SUZ-4 catalyst resulted in a slight shift of activity profile toward higher temperatures, yielding an increase of NO conversion by 16% and a decrease of NO x conversion by 15% at 525C. The effect of H 2 O and SO 2 on the aged catalyst was to reduce the NO activity by 20% and NO x activity by 30% at 500C. The effect of space velocity change was not significant except in the low temperature range where the reaction light-off occurs. Adsorption/desorption measurements indicate that aging Cu/SUZ-4 results in partial migration/agglomeration of Cu particles in the pores thereby reducing the NO/NO x activity. Overall, the NO x conversion efficiency of Cu/SUZ-4, for both fresh and aged, is much better than the benchmark Cu/ZSM-5 in the presence of H 2 O and/or SO 2

  12. Electrocatalysts and their Supporting Materials for Proton Exchange Membrane Fuel Cells: Activity and Durability Studies

    DEFF Research Database (Denmark)

    Permyakova, Anastasia Aleksandrovna

    other methods. The thesis begins with an introduction in Chapter 1 providing an overview of fuel cells, their associated reaction mechanisms, catalysts and catalysts supports. Chapter 2 presents the theoretical background to the study including equipment and the techniques used to analyse the catalysts......This thesis describes investigations conducted exploring the activity, stability and durability of supported nano-particulate, bulk and thin film electrocatalysts used in proton exchange membrane fuel cells (PEMFCs). The effects of different factors and conditions on the reactions involved...

  13. Summary of JRC activities related to European-wide exchange of radiological information during nuclear emergencies

    International Nuclear Information System (INIS)

    De Court, M.; Vries de, G.; Galmarini, S.

    2003-01-01

    Full text: The large transboundary effects of the radioactive release during the Chernobyl accident evidenced the need for international provisions for data and Information exchange. The JRC, in its EC support activity to DG TREN H.4, called REM (Radioactivity Environmental Monitoring), has more than 10 years experience in developing systems to make early notification and reliable radiological information exchange available to the EU member states in case of nuclear accidents. The aim and status of these systems are described: 1.)ECURIE: The legal basis for the EC systems is the Council Decision 87/600 of 14 December 1987. It resulted in the ECURIE network which allows the EU Member States and Switzerland to notify an accident and to subsequently exchange the radiological information as required by this Council decision. The underlying information exchange code (C.1. structure) does not only provide radiological measurements, but also predicted values, site meteorological data and decisions taken. Software was developed to facilitate coding and decoding of the messages. Initially the messages were transmitted by telex. The latest software (CoDecS, in use since the beginning of 2001) uses ISDN and Internet for the Information exchange. lt runs an the Windows NT and 2000 platforms. Regular exercises test the communication system and the software. In view of improving the efficiency of data and Information transfer for their common Member States, the IAEA and the EC are harmonizing ECURIE and the ENATOM early notification system. A first result has been the definition of an enhanced CIS format. Modifications will be made to the CoDecs software and to the IAEA - ENAC website so that information can be exchanged between the two systems in an automated manner. The EC wishes to extend the ECURIE network to the EU candidate countries. The official agreements are in an advanced state and participation of many candidate countries is foreseen by the end of 2003. It is

  14. Leak Detection in Heat Exchangers and Underground Pipelines Using Radiotracers. Material for Education and On-The-Job Training for Practitioners of Radiotracer Technology

    International Nuclear Information System (INIS)

    2009-01-01

    The International Atomic Energy Agency plays a major role in facilitating the transfer of radiotracer technology to developing Member States. The use of radiotracer techniques is well established in many Member States; some hundred radiotracer and end user specialists have been trained in radiotracer techniques and their applications; nearly 50 radiotracer laboratories have been working in this field. The training of radiotracer practitioners is vital for the provision of quality services to industry. Leak detection using radiotracer techniques is probably one of the most widespread applications of radiotracers in industrial troubleshooting. Radiotracer techniques are the most competitive for online leak inspection of heat exchangers and buried pipelines. Radiotracers help in early detection of leaks in heat exchangers and underground transporting pipelines, thus saving money, reducing shutdown time, ensuring safe operation and protecting the environment from pollution. The training course series on leak detection in heat exchangers and underground pipelines using radiotracers addresses the needs of the radiotracer groups and their end users. Besides training purposes, this material will assist radiotracer groups in establishing their quality control and accreditation systems. This training course material is based on lecture notes and practical work delivered by many experts in IAEA-supported activities. In particular, the Technical Cooperation Projects implemented under the Regional Cooperative Agreement (RCA) of the IAEA Member States in the Asia and the Pacific Region have been successful in transferring and implementing radiotracer techniques for leak detection to many end users from oil and gas production, oil refineries and the petrochemical industry. The experience obtained in the RCA Region is presented in the training material illustrated with many case studies carried out in several RCA Member States. Lectures and case studies were reviewed by a number

  15. Energy and environmentally appropriate technologies: a selectively annotated bibliography. Council of Planning Librarians exchange bibliography 1126

    Energy Technology Data Exchange (ETDEWEB)

    Piasetzki, J.P.

    1976-09-01

    The bibliography contains readings to provide assistance to those interested in environmentally appropriate technologies, with specific emphasis on energy producing equipment. A general listing with approximately 225 citations, a listing of 9 periodicals, a list of 6 information sources, and a list of 3 information publications are included. (MCW)

  16. Intricate but tight coupling of spiracular activity and abdominal ventilation during locust discontinuous gas exchange cycles.

    Science.gov (United States)

    Talal, Stav; Gefen, Eran; Ayali, Amir

    2018-03-15

    Discontinuous gas exchange (DGE) is the best studied among insect gas exchange patterns. DGE cycles comprise three phases, which are defined by their spiracular state: closed, flutter and open. However, spiracle status has rarely been monitored directly; rather, it is often assumed based on CO 2 emission traces. In this study, we directly recorded electromyogram (EMG) signals from the closer muscle of the second thoracic spiracle and from abdominal ventilation muscles in a fully intact locust during DGE. Muscular activity was monitored simultaneously with CO 2 emission, under normoxia and under various experimental oxic conditions. Our findings indicate that locust DGE does not correspond well with the commonly described three-phase cycle. We describe unique DGE-related ventilation motor patterns, coupled to spiracular activity. During the open phase, when CO 2 emission rate is highest, the thoracic spiracles do not remain open; rather, they open and close rapidly. This fast spiracle activity coincides with in-phase abdominal ventilation, while alternating with the abdominal spiracle and thus facilitating a unidirectional air flow along the main trachea. A change in the frequency of rhythmic ventilation during the open phase suggests modulation by intra-tracheal CO 2 levels. A second, slow ventilatory movement pattern probably serves to facilitate gas diffusion during spiracle closure. Two flutter-like patterns are described in association with the different types of ventilatory activity. We offer a modified mechanistic model for DGE in actively ventilating insects, incorporating ventilatory behavior and changes in spiracle state. © 2018. Published by The Company of Biologists Ltd.

  17. Thyroid hormones increase Na -H exchange activity in renal brush border membranes

    Energy Technology Data Exchange (ETDEWEB)

    Kinsella, J.; Sacktor, B.

    1985-06-01

    Na -H exchange activity, i.e., amiloride-sensitive Na and H flux, in renal proximal tubule brush border (luminal) membrane vesicles was increased in the hyperthyroid rat and decreased in the hypothyroid rat, relative to the euthyroid animal. A positive correlation was found between Na -H exchange activity and serum concentrations of thyroxine (T4) and triiodothyronine (T3). The thyroid status of the animal did not alter amiloride-insensitive Na uptake. The rate of passive pH gradient dissipation was higher in membrane vesicles from hyperthyroid rats compared to the rate in vesicles from hypothyroid animals, a result which would tend to limit the increase in Na uptake in vesicles from hyperthyroid animals. Na -dependent phosphate uptake was increased in membrane vesicles from hyperthyroid rats; Na -dependent D-glucose and L-proline uptakes were not changed by the thyroid status of the animal. The effect of thyroid hormones in increasing the uptake of Na in the brush border membrane vesicle is consistent with the action of the hormones in enhancing renal Na reabsorption.

  18. Regeneration of the iodine isotope-exchange efficiency for nuclear-grade activated carbons

    International Nuclear Information System (INIS)

    Deitz, V.R.

    1985-01-01

    The removal of radioactive iodine from air flows passing through impregnated activated carbons depends on a minimum of three distinguishable reactions: (1) adsorption on the carbon networks of the activated carbons, (2) iodine isotope exchange with impregnated iodine-127, and (3) chemical combination with impregnated tertiary amines when present. When a carbon is new, all three mechanisms are at peak performance and it is not possible to distinguish among the three reactions by a single measurement; the retention of methyl iodide-127 is usually equal to the retention of methyl iodide-131. After the carbon is placed in service, the three mechanisms of iodine removal are degraded by the contaminants of the air at different rates; the adsorption process degrades faster than the other two. This behavior will be shown by comparisons of methyl iodide-127 and methyl iodide-131 penetration tests. It was found possible to regenerate the iodine isotope-exchange efficiency by reaction with airborne chemical reducing agents with little or no improvement in methyl iodine-127 retention. Examples will be given of the chemical regeneration of carbons after exhaustion with known contaminants as well as for many carbons removed from nuclear power operations. The depth profile of methyl iodide-131 penetration was determined in 2-inch deep layers before and after chemical treatments

  19. A NEATER [robot] advance in active handling technology

    International Nuclear Information System (INIS)

    Abel, E.; Watson, C.J.H.

    1990-01-01

    The NEATER robot manipulator, commercially launched in December 1989 by AEA Technology and Staubli Unimation, arose from the recognition that technological advances in the non-nuclear robotics industry were beginning to outstrip those in the nuclear active handling sector. Its development from an industrial robot controller design is described. (author)

  20. Provide, obtain and exchange information: the e-publishing technology information platform CARPET

    Directory of Open Access Journals (Sweden)

    Felix Schüle

    2012-11-01

    Full Text Available Scientific communication has been radically changed by electronic publishing (e-publishing technology. Today, knowledge travels the globe at enormous speed and is accessible everywhere. The success of e-publishing is the result of many projects or individual endeavours which have developed technical solutions for publishing tasks. The software is mostly released under an Open Source licence and the re-use of existing tools and services is often the most effective way for institutions looking to set up an e-publishing system. But information on e-publishing tools and services is often hard to get or tends not to get passed on. In order to fill this gap, the CARPET platform provides information on e-publishing technology and supports the sustainability of existing e-publishing projects and their solutions.

  1. Proton exchange membrane materials for the advancement of direct methanol fuel-cell technology

    Science.gov (United States)

    Cornelius, Christopher J [Albuquerque, NM

    2006-04-04

    A new class of hybrid organic-inorganic materials, and methods of synthesis, that can be used as a proton exchange membrane in a direct methanol fuel cell. In contrast with Nafion.RTM. PEM materials, which have random sulfonation, the new class of materials have ordered sulfonation achieved through self-assembly of alternating polyimide segments of different molecular weights comprising, for example, highly sulfonated hydrophilic PDA-DASA polyimide segment alternating with an unsulfonated hydrophobic 6FDA-DAS polyimide segment. An inorganic phase, e.g., 0.5 5 wt % TEOS, can be incorporated in the sulfonated polyimide copolymer to further improve its properties. The new materials exhibit reduced swelling when exposed to water, increased thermal stability, and decreased O.sub.2 and H.sub.2 gas permeability, while retaining proton conductivities similar to Nafion.RTM.. These improved properties may allow direct methanol fuel cells to operate at higher temperatures and with higher efficiencies due to reduced methanol crossover.

  2. Technology and Policy Challenges in the Adoption and Operation of Health Information Exchange Systems.

    Science.gov (United States)

    Ji, Hyerim; Yoo, Sooyoung; Heo, Eun-Young; Hwang, Hee; Kim, Jeong-Whun

    2017-10-01

    This study aimed to identify problems and issues that arise with the implementation of online health information exchange (HIE) systems in a medical environment and to identify solutions to facilitate the successful operation of future HIE systems in primary care clinics and hospitals. In this study, the issues that arose during the establishment and operation of an HIE system in a hospital were identified so that they could be addressed to enable the successful establishment and operation of a standard-based HIE system. After the issues were identified, they were reviewed and categorized by a group of experts that included medical information system experts, doctors, medical information standard experts, and HIE researchers. Then, solutions for the identified problems were derived based on the system development, operation, and improvement carried out during this work. Twenty-one issues were identified during the implementation and operation of an online HIE system. These issues were then divided into four categories: system architecture and standards, documents and data items, consent of HIE, and usability. We offer technical and policy recommendations for various stakeholders based on the experiences of operating and improving the online HIE system in the medical field. The issues and solutions identified in this study regarding the implementation and operate of an online HIE system can provide valuable insight for planners to enable them to successfully design and operate such systems at a national level in the future. In addition, policy support from governments is needed.

  3. Proceedings of the workshop for exchange of technology for CWC inspections

    Energy Technology Data Exchange (ETDEWEB)

    McGuire, R.R.

    1993-04-01

    With the signing of the Chemical Weapons Convention (CWC), the work of the Preparatory Commission in defining the modalities of on-site verification inspections will begin early in 1993. One of the methods for increasing the effectiveness of inspections is the collection of samples for chemical analysis. The CWC allows for this analysis to be performed either at the site of the inspection or in a dedicated off-site laboratory. The decision as to where samples are to be analyzed in any specific instance may involve a consideration of the threat, real or perceived, to the compromise of legitimate sensitive host-party information. The ability to perform efficient chemical analysis at the inspection site, where samples remain in joint (host-inspector) custody and the analytical procedures can be observed by the host, can alleviate much of the concern over possible loss of confidential information in both government and industry. This workshop was designed to encourage the exchange of information among participants with experience in the use of analytical equipment for on-site sample collection and analysis. Individual projects are processed separately for the databases.

  4. Heat exchanger technologies for the global environment. PWR-Vol. 25

    International Nuclear Information System (INIS)

    Maurer, J.R.

    1994-01-01

    This is the Committee's largest compilation of papers in the fourteen years that ASME has sponsored one or more sessions at the Joint Power Generation Conference. In addition to the twenty-two papers offered at the conference, one session contained a panel discussion during which five industry specialists related their experiences and interpretations. Many of the presentations of the past few years have been made by authors from foreign lands as the conference has expanded to an international forum. This years' theme of global impact is included in the heat exchanger presentations from the USA and abroad. In addition, ASME has encouraged authors to make the subjects of their presentations more apropos to current concerns. New concepts and designs, particularly with PC programs in mind, is one specific area that is addressed. Other topics such as materials selection, coatings to extend performance life, minimizing the effects of microbiologically influenced corrosion, zebra mussel control and new approaches to heat transfer design are some of the subjects covered at the conference and in this volume. Nineteen papers have been processed separately for inclusion in the appropriate data bases

  5. Technological research plan for active ageing

    NARCIS (Netherlands)

    Afsarmanesh, H.; Msanjila, S.S.; Camarinha-Matos, L.M.

    2012-01-01

    The ePAL initiative aimed at developing a roadmap for extension of professional active life of the retiring and retired knowledge workers in developed countries and specifically in Europe. Three main perspectives are identified in this roadmap, and defined to comprehensively address relevant

  6. CMOS Active Pixel Sensor Technology and Reliability Characterization Methodology

    Science.gov (United States)

    Chen, Yuan; Guertin, Steven M.; Pain, Bedabrata; Kayaii, Sammy

    2006-01-01

    This paper describes the technology, design features and reliability characterization methodology of a CMOS Active Pixel Sensor. Both overall chip reliability and pixel reliability are projected for the imagers.

  7. Promoted Iron Nanocrystals Obtained via Ligand Exchange as Active and Selective Catalysts for Synthesis Gas Conversion.

    Science.gov (United States)

    Casavola, Marianna; Xie, Jingxiu; Meeldijk, Johannes D; Krans, Nynke A; Goryachev, Andrey; Hofmann, Jan P; Dugulan, A Iulian; de Jong, Krijn P

    2017-08-04

    Colloidal synthesis routes have been recently used to fabricate heterogeneous catalysts with more controllable and homogeneous properties. Herein a method was developed to modify the surface composition of colloidal nanocrystal catalysts and to purposely introduce specific atoms via ligands and change the catalyst reactivity. Organic ligands adsorbed on the surface of iron oxide catalysts were exchanged with inorganic species such as Na 2 S, not only to provide an active surface but also to introduce controlled amounts of Na and S acting as promoters for the catalytic process. The catalyst composition was optimized for the Fischer-Tropsch direct conversion of synthesis gas into lower olefins. At industrially relevant conditions, these nanocrystal-based catalysts with controlled composition were more active, selective, and stable than catalysts with similar composition but synthesized using conventional methods, possibly due to their homogeneity of properties and synergic interaction of iron and promoters.

  8. U.S.-MEXICO TECHNOLOGY TRANSFER; BILATERAL TECHNICAL EXCHANGES FOR SUSTAINABLE ECONOMIC GROWTH IN THE BORDER REGION

    Energy Technology Data Exchange (ETDEWEB)

    Jimenez, Richard, D., Dr.

    2007-10-01

    The U.S. Department of Energy (DOE) maintains a strong commitment to transfer the results of its science and technology programs to the private sector. The intent is to apply innovative and sometimes advanced technologies to address needs while simultaneously stimulating new commercial business opportunities. Such focused “technology transfer” was evident in the late 1990s as the results of DOE investments in environmental management technology development led to new tools for characterizing and remediating contaminated sites as well as handling and minimizing the generation of hazardous wastes. The Department’s Office of Environmental Management was attempting to reduce the cost, accelerate the schedule, and improve the efficacy of clean-up efforts in the nuclear weapons complex. It recognized that resulting technologies had broader world market applications and that their commercialization would further reduce costs and facilitate deployment of improved technology at DOE sites. DOE’s Albuquerque Operations Office (now part of the National Nuclear Security Administration) began in 1995 to build the foundation for a technology exchange program with Mexico. Initial sponsorship for this work was provided by the Department’s Office of Environmental Management. As part of this effort, Applied Sciences Laboratory, Inc. (ASL) was contracted by the DOE Albuquerque office to identify Mexico’s priority environmental management needs, identify and evaluate DOE-sponsored technologies as potential solutions for those needs, and coordinate these opportunities with decision makers from Mexico’s federal government. That work led to an improved understanding of many key environmental challenges that Mexico faces and the many opportunities to apply DOE’s technologies to help resolve them. The above results constituted, in large part, the foundation for an initial DOE-funded program to apply the Department’s technology base to help address some of Mexico

  9. Activation of microglia depends on Na+/H+ exchange-mediated H+ homeostasis.

    Science.gov (United States)

    Liu, Yan; Kintner, Douglas B; Chanana, Vishal; Algharabli, Jehad; Chen, Xinzhi; Gao, Yanqin; Chen, Jun; Ferrazzano, Peter; Olson, Julie K; Sun, Dandan

    2010-11-10

    H(+) extrusion is important for sustained NADPH oxidase activation after "respiratory" burst in macrophage/microglia activation. In this study, we investigated the role of Na(+)/H(+) exchanger isoform 1 (NHE-1) in activation of microglia after lipopolysaccharide (LPS) or oxygen and glucose deprivation and reoxygenation (OGD/REOX) exposure. NHE-1 functioned in maintaining basal pH(i) of immortalized M4T.4 microglia or mouse primary microglia. Pharmacological inhibition of NHE-1 activity with the potent inhibitor cariporide [HOE 642 (4-isopropyl-3-methylsulfonyl-benzoyl-guanidine-methanesulfonate)] abolished pH(i) regulation in microglia under basal conditions. Activation of microglia either by LPS, phorbol myristate acetate, or OGD/REOX accelerated pH(i) regulation and caused pH(i) elevation, which was accompanied with an increase in [Na(+)](i) and [Ca(2+)](i) as well as production of superoxide anion and cytokines. Interestingly, inhibition of NHE-1 not only abolished pH(i) regulation but also reduced production of superoxide anion as well as expression of cytokines and inducible nitric oxide synthase. Together, these results reveal that there was a concurrent activation of NHE-1 in microglia in response to proinflammatory stimuli. The study suggests that NHE-1 functions to maintain microglial pH(i) homeostasis allowing for sustained NADPH oxidase function and "respiratory" burst.

  10. Irreversible catalyst activation enables hyperpolarization and water solubility for NMR signal amplification by reversible exchange.

    Science.gov (United States)

    Truong, Milton L; Shi, Fan; He, Ping; Yuan, Bingxin; Plunkett, Kyle N; Coffey, Aaron M; Shchepin, Roman V; Barskiy, Danila A; Kovtunov, Kirill V; Koptyug, Igor V; Waddell, Kevin W; Goodson, Boyd M; Chekmenev, Eduard Y

    2014-12-04

    Activation of a catalyst [IrCl(COD)(IMes)] (IMes = 1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene; COD = cyclooctadiene)] for signal amplification by reversible exchange (SABRE) was monitored by in situ hyperpolarized proton NMR at 9.4 T. During the catalyst-activation process, the COD moiety undergoes hydrogenation that leads to its complete removal from the Ir complex. A transient hydride intermediate of the catalyst is observed via its hyperpolarized signatures, which could not be detected using conventional nonhyperpolarized solution NMR. SABRE enhancement of the pyridine substrate can be fully rendered only after removal of the COD moiety; failure to properly activate the catalyst in the presence of sufficient substrate can lead to irreversible deactivation consistent with oligomerization of the catalyst molecules. Following catalyst activation, results from selective RF-saturation studies support the hypothesis that substrate polarization at high field arises from nuclear cross-relaxation with hyperpolarized (1)H spins of the hydride/orthohydrogen spin bath. Importantly, the chemical changes that accompanied the catalyst's full activation were also found to endow the catalyst with water solubility, here used to demonstrate SABRE hyperpolarization of nicotinamide in water without the need for any organic cosolvent--paving the way to various biomedical applications of SABRE hyperpolarization methods.

  11. Active heat exchange system development for latent heat thermal energy storage

    Science.gov (United States)

    Alario, J.; Haslett, R.

    1980-01-01

    Various active heat exchange concepts were identified from among three generic categories: scrapers, agitators/vibrators and slurries. The more practical ones were given a more detailed technical evaluation and an economic comparison with a passive tube-shell design for a reference application. Two concepts selected for hardware development are a direct contact heat exchanger in which molten salt droplets are injected into a cooler counterflowing stream of liquid metal carrier fluid, and a rotating drum scraper in which molten salt is sprayed onto the circumference of a rotating drum, which contains the fluid heat sink in an internal annulus near the surface. A fixed scraper blade removes the solidified salt from the surface which has been nickel plated to decrease adhesion forces. Suitable phase change material (PCM) storage media with melting points in the temperature range of interest (250 C to 400 C) were investigated. The specific salt recommended for laboratory tests was a chloride eutectic (20.5KCl-24/5 NaCl-55.0MgCl 2% by wt.), with a nominal melting point of 385 C.

  12. Regulation of mitogen-activated protein kinase pathways by the plasma membrane Na+/H+ exchanger, NHE1

    DEFF Research Database (Denmark)

    Pedersen, Stine Helene Falsig; Darborg, Barbara Vasek; Rentsch, Maria Louise

    2006-01-01

    activity is regulated by a three-tiered phosphorelay system, which is in turn regulated by a complex network of signaling events and scaffolding proteins. The ubiquitous plasma membrane Na(+)/H(+) exchanger NHE1 is activated by, and implicated in, the physiological/pathophysiological responses to many...

  13. Active, Non-Intrusive Inspection Technologies for Homeland Defense

    Energy Technology Data Exchange (ETDEWEB)

    James L. Jones

    2003-06-01

    Active, non-intrusive inspection or interrogation technologies have been used for 100 years - with the primary focus being radiographic imaging. During the last 50 years, various active interrogation systems have been investigated and most have revealed many unique and interesting capabilities and advantages that have already benefited the general public. Unfortunately, except for medical and specific industrial applications, these unique capabilities have not been widely adopted, largely due to the complexity of the technology, the overconfident reliance on passive detection systems to handle most challenges, and the unrealistic public concerns regarding radiation safety issues for a given active inspection deployment. The unique homeland security challenges facing the United States today are inviting more "out-of-the-box" solutions and are demanding the effective technological solutions that only active interrogation systems can provide. While revolutionary new solutions are always desired, these technology advancements are rare, and when found, usually take a long time to fully understand and implement for a given application. What's becoming more evident is that focusing on under-developed, but well-understood, active inspection technologies can provide many of the needed "out-of-the-box" solutions. This paper presents a brief historical overview of active interrogation. It identifies some of the major homeland defense challenges being confronted and the commercial and research technologies presently available and being pursued. Finally, the paper addresses the role of the Idaho National Engineering and Environmental Laboratory and its partner, the Idaho Accelerator Center at Idaho State University, in promoting and developing active inspection technologies for homeland defense.

  14. Does oxidative stress affect the activity of the sodium-proton exchanger?

    Science.gov (United States)

    Bober, Joanna; Kedzierska, Karolina; Kwiatkowska, Ewa; Stachowska, Ewa; Gołembiewska, Edyta; Mazur, Olech; Staniewicz, Zdzisław; Ciechanowski, Kazimierz; Chlubek, Dariusz

    2010-01-01

    Accumulation of reactive oxygen species (ROS) takes place in patients with chronic renal failure (CRF). Oxidative stress causes disorders in the activity of the sodium-proton exchanger (NHE). Studies on NHE in CRF produced results that are discrepant and difficult to interpret. The aim of this study was to demonstrate that oxidative stress had an effect on the activity of NHE. We enrolled 87 subjects divided into 4 groups: patients with CRF treated conservatively; patients with CRF hemodialyzed without glucose--HD-g(-); patients with CRF hemodialyzed with glucose--HD-g(+); controls (C). The activity of NHE, the rate of proton efflux V(max), Michaelis constant (Km), and the concentration of thiobarbituric acid-reactive substances (TBARS, an indicator of oxidative stress) in plasma, as well as the concentration of reduced glutathione in blood were determined. The concentration of TBARS was significantly higher in hemodialyzed patients before and after dialysis and in patients with CRF on conservative treatment in comparison with group C. TBARS in plasma correlated negatively with VpH(i)6.4 in group C and with V(max) and VpH(i)6.4 after HD in group HD-g(-). We found that the concentration of creatinine correlated with TBARS (p < 0.0001; r = +0.51) in the conservatively treated group. We observed a marked oxidative stress and decreased NHE activity when dialysis was done without glucose, whereas patients dialyzed with glucose demonstrated a relatively low intensity of oxidative stress.

  15. Radiation protection in radiologic technology: Apathy versus active involvement

    International Nuclear Information System (INIS)

    Franz, K.H.

    1982-01-01

    The lack of active participation in radiation protection is a serious problem in Radiologic Technology today. Underlying the problem is professional apathy. An overview of the historical changes, as well as various recent developments in radiology, accentuate the importance of necessary changes in technologists' attitudes and activities. 22 references

  16. Radiation protection in radiologic technology: Apathy versus active involvement

    Energy Technology Data Exchange (ETDEWEB)

    Franz, K.H.

    1982-11-01

    The lack of active participation in radiation protection is a serious problem in Radiologic Technology today. Underlying the problem is professional apathy. An overview of the historical changes, as well as various recent developments in radiology, accentuate the importance of necessary changes in technologists' attitudes and activities. 22 references.

  17. The recent situation of technology exchange in Europe: On-the spot study on movement toward integration of EC market

    Science.gov (United States)

    Kawasaki, Jun'ichi; Hyoki, Yasuyoshi

    The political and economic environment of EC has been changing drastically aiming at the EC market integration in 1992. Economy in EC has been stagnant among free economy world covering U.S., Japan and Europe, which is due to lag in the structural adjustment as well as decline in international competitive ability. EC recognizes that development of science and technology of which core is highly advanced technology is driving force for activating economy within the Community. This is the first motivation for EC to take one step forward toward the market integration. Such EC's determination is reflected in pushing forward conception of European technological community represented by EUREKA Project. Products Exhibitions, Science and Technology Trade Fairs and so on, which are held in EC countries, emphasize "Europe characterized by Technology" being conscious of the market integration three and a half years ahead. EC is also eager to construct database networks both inside and outside the Community to catch up with the progress in technology.

  18. A Fasting Inducible Switch Modulates Gluconeogenesis Via Activator-Coactivator Exchange

    Science.gov (United States)

    Liu, Yi; Dentin, Renaud; Chen, Danica; Hedrick, Susan; Ravnskjaer, Kim; Schenk, Simon; Milne, Jill; Meyers, David J.; Cole, Phil; Yates, John; Olefsky, Jerrold; Guarente, Leonard; Montminy, Marc

    2008-01-01

    During early fasting, increases in skeletal muscle proteolysis liberate free amino acids for hepatic gluconeogenesis in response to pancreatic glucagon. Hepatic glucose output diminishes during the late protein-sparing phase of fasting, when ketone body production by the liver supplies compensatory fuel for glucose-dependent tissues 1–4. Glucagon stimulates the gluconeogenic program by triggering the dephosphorylation and nuclear translocation of the CREB regulated transcription coactivator 2 (CRTC2; also known as TORC2), while parallel decreases in insulin signaling augment gluconeogenic gene expression through the de-phosphorylation and nuclear shuttling of Forkhead Box O1 (FOXO1) 5–7. Here we show that a fasting-inducible switch, consisting of the histone acetyl-transferase (HAT) P300 and the nutrient-sensing deacetylase Sirtuin 1 (SIRT1), maintains energy balance through the sequential induction of CRTC2 and FOXO1. Following glucagon induction, CRTC2 stimulated gluconeogenic gene expression through an association with P300, which we show here is also activated by de-phosphorylation at Ser89 during fasting. In turn, P300 increased hepatic CRTC2 activity by acetylating it at Lys628, a site that also targets CRTC2 for degradation following its ubiquitination by the E3 ligase Constitutive Photomorphogenic Protein (COP1) 8. Glucagon effects were attenuated during late fasting, when CRTC2 was down-regulated due to SIRT1-mediated deacetylation and when FOXO1 supported expression of the gluconeogenic program. Disrupting SIRT1 activity, by liver-specific knockout of the SIRT1 gene or by administration of SIRT1 antagonist, increased CRTC2 activity and glucose output, while exposure to SIRT1 agonists reduced them. In view of the reciprocal activation of FOXO1 and its coactivator peroxisome proliferator activated receptor gamma coactivator 1 alpha (PGC-1α) by SIRT1 activators 9–12, our results illustrate how the exchange of two gluconeogenic regulators during

  19. A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange.

    Science.gov (United States)

    Liu, Yi; Dentin, Renaud; Chen, Danica; Hedrick, Susan; Ravnskjaer, Kim; Schenk, Simon; Milne, Jill; Meyers, David J; Cole, Phil; Yates, John; Olefsky, Jerrold; Guarente, Leonard; Montminy, Marc

    2008-11-13

    During early fasting, increases in skeletal muscle proteolysis liberate free amino acids for hepatic gluconeogenesis in response to pancreatic glucagon. Hepatic glucose output diminishes during the late protein-sparing phase of fasting, when ketone body production by the liver supplies compensatory fuel for glucose-dependent tissues. Glucagon stimulates the gluconeogenic program by triggering the dephosphorylation and nuclear translocation of the CREB regulated transcription coactivator 2 (CRTC2; also known as TORC2), while parallel decreases in insulin signalling augment gluconeogenic gene expression through the dephosphorylation and nuclear shuttling of forkhead box O1 (FOXO1). Here we show that a fasting-inducible switch, consisting of the histone acetyltransferase p300 and the nutrient-sensing deacetylase sirtuin 1 (SIRT1), maintains energy balance in mice through the sequential induction of CRTC2 and FOXO1. After glucagon induction, CRTC2 stimulated gluconeogenic gene expression by an association with p300, which we show here is also activated by dephosphorylation at Ser 89 during fasting. In turn, p300 increased hepatic CRTC2 activity by acetylating it at Lys 628, a site that also targets CRTC2 for degradation after its ubiquitination by the E3 ligase constitutive photomorphogenic protein (COP1). Glucagon effects were attenuated during late fasting, when CRTC2 was downregulated owing to SIRT1-mediated deacetylation and when FOXO1 supported expression of the gluconeogenic program. Disrupting SIRT1 activity, by liver-specific knockout of the Sirt1 gene or by administration of a SIRT1 antagonist, increased CRTC2 activity and glucose output, whereas exposure to SIRT1 agonists reduced them. In view of the reciprocal activation of FOXO1 and its coactivator peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha, encoded by Ppargc1a) by SIRT1 activators, our results illustrate how the exchange of two gluconeogenic regulators during fasting

  20. Technology and industrialization in Spanish economy from 1950 to 1960: the patents as technological activity indicators

    International Nuclear Information System (INIS)

    Hidalgo Nuchera, A.; Molero Zayas, J.; Granda Gayo, I.

    2007-01-01

    The goal of this research is to study the innovative activity developed in the fifties by the Spanish industry focussing on the foreign technology incorporated in the activity of several industrial sectors. The structure of innovation in each sector has been characterized by using patents as technological activity indicators. The data of patents registered in Spain belonging to the 1950-1960 period have been obtained taking into account the research developed by the Department of Business Administration of the Universidad Politecnica de Madrid through a subsidy granted by the Spanish Patent Office. (Author)

  1. Disease Mutations in Rab7 Result in Unregulated Nucleotide Exchange and Inappropriate Activation

    Energy Technology Data Exchange (ETDEWEB)

    B McCray; E Skordalakes; J Taylor

    2011-12-31

    Rab GTPases are molecular switches that orchestrate vesicular trafficking, maturation and fusion by cycling between an active, GTP-bound form, and an inactive, GDP-bound form. The activity cycle is coupled to GTP hydrolysis and is tightly controlled by regulatory proteins. Missense mutations of the GTPase Rab7 cause a dominantly inherited axonal degeneration known as Charcot-Marie-Tooth type 2B through an unknown mechanism. We present the 2.8 A crystal structure of GTP-bound L129F mutant Rab7 which reveals normal conformations of the effector binding regions and catalytic site, but an alteration to the nucleotide binding pocket that is predicted to alter GTP binding. Through extensive biochemical analysis, we demonstrate that disease-associated mutations in Rab7 do not lead to an intrinsic GTPase defect, but permit unregulated nucleotide exchange leading to both excessive activation and hydrolysis-independent inactivation. Consistent with augmented activity, mutant Rab7 shows significantly enhanced interaction with a subset of effector proteins. In addition, dynamic imaging demonstrates that mutant Rab7 is abnormally retained on target membranes. However, we show that the increased activation of mutant Rab7 is counterbalanced by unregulated, GTP hydrolysis-independent membrane cycling. Notably, disease mutations are able to rescue the membrane cycling of a GTPase-deficient mutant. Thus, we demonstrate that disease mutations uncouple Rab7 from the spatial and temporal control normally imposed by regulatory proteins and cause disease not by a gain of novel toxic function, but by misregulation of native Rab7 activity.

  2. An Activity Systems Theory Approach to Agent Technology

    OpenAIRE

    Zhang, Peng; Bai, Guohua

    2005-01-01

    In the last decade, Activity Theory has been discussed a lot in Human-Computer Interaction (HCI) and Computer Supported Cooperative Work (CSCW). Activity Theory was used both theoretically as an analytical method and practically as a development framework for Information Systems. Meanwhile, there is a new trench from Artificial Intelligence. Artificial Intelligence researchers find that the fruit from Activity Theory study may contribute, especially to Agent Technology, with socio-psychologic...

  3. Active magnetic regenerator refrigeration with rotary multi-bed technology

    DEFF Research Database (Denmark)

    Eriksen, Dan

    Magnetic refrigeration is an emerging cooling technology with potential ad- vantages over conventional vapor compression, the most important being higher efficiency. This thesis presents experimental and theoretical research into the possibilities of realizing this potential with actual active...... with a thermal storage is introduced and demonstrated experimentally. Furthermore, a novel shunt valve technology, which was developed as a spin-off from the magnetic refrigeration research, is presented....

  4. IAEA activities in technology development for advanced water-cooled nuclear power plants

    International Nuclear Information System (INIS)

    Juhn, Poong Eil; Kupitz, Juergen; Cleveland, John; Lyon, Robert; Park, Je Won

    2003-01-01

    As part of its Nuclear Power Programme, the IAEA conducts activities that support international information exchange, co-operative research and technology assessments and advancements with the goal of improving the reliability, safety and economics of advanced water-cooled nuclear power plants. These activities are conducted based on the advice, and with the support, of the IAEA Department of Nuclear Energy's Technical Working Groups on Advanced Technologies for Light Water Reactors (LWRs) and Heavy Water Reactors (HWRs). Assessments of projected electricity generation costs for new nuclear plants have shown that design organizations are challenged to develop advanced designs with lower capital costs and short construction times, and sizes, including not only large evolutionary plants but also small and medium size plants, appropriate to grid capacity and owner financial investment capability. To achieve competitive costs, both proven means and new approaches should be implemented. The IAEA conducts activities in technology development that support achievement of improved economics of water-cooled nuclear power plants (NPPs). These include fostering information sharing and cooperative research in thermo-hydraulics code validation; examination of natural circulation phenomena, modelling and the reliability of passive systems that utilize natural circulation; establishment of a thermo-physical properties data base; improved inspection and diagnostic techniques for pressure tubes of HWRs; and collection and balanced reporting from recent construction and commissioning experiences with evolutionary water-cooled NPPs. The IAEA also periodically publishes Status Reports on global development of advanced designs. (author)

  5. Gas exchange and antioxidant activity in seedlings of C opaifera langsdorffii Desf. under different water conditions

    Directory of Open Access Journals (Sweden)

    DEREK B.C.J. ROSA

    Full Text Available ABSTRACT The aim of this study was to evaluate gas exchange, efficiency of the photosynthetic apparatus, and antioxidant activity in Copaifera langsdorffii Desf. The seedlings were cultivated under different conditions of water availability, in order to improve the utilization efficiency of available water resources. The seedlings were cultivated in four different water retention capacities (WRC- 25%, 50%, 75%, and 100%, and evaluated at four different time (T- 30, 60, 90, and 120 days. During the experimental period, seedlings presented the highest values for carboxylation efficiency of Rubisco (A/Ci, intrinsic water use efficiency (IWUE = A/gs, chlorophyll index, and stomatal opening, when grown in the substrate with 75% WRC, but the stomatal index (SI was less the 25% WRC. The efficiency of photosystem II was not significantly altered by the treatments. Comparison between the extreme treatments in terms of water availability, represented by 25% and 100% WRC, represent stress conditions for the species. Water availability causes a high activity of antioxidant enzymes (superoxide dismutase, peroxidase, and catalase in the plant.

  6. Gas exchange and antioxidant activity in seedlings of C opaifera langsdorffii Desf. under different water conditions.

    Science.gov (United States)

    Rosa, Derek B C J; Scalon, Silvana P Q; Cremon, Thais; Ceccon, Felipe; Dresch, Daiane M

    2017-01-01

    The aim of this study was to evaluate gas exchange, efficiency of the photosynthetic apparatus, and antioxidant activity in Copaifera langsdorffii Desf. The seedlings were cultivated under different conditions of water availability, in order to improve the utilization efficiency of available water resources. The seedlings were cultivated in four different water retention capacities (WRC- 25%, 50%, 75%, and 100%), and evaluated at four different time (T- 30, 60, 90, and 120 days). During the experimental period, seedlings presented the highest values for carboxylation efficiency of Rubisco (A/Ci), intrinsic water use efficiency (IWUE = A/gs), chlorophyll index, and stomatal opening, when grown in the substrate with 75% WRC, but the stomatal index (SI) was less the 25% WRC. The efficiency of photosystem II was not significantly altered by the treatments. Comparison between the extreme treatments in terms of water availability, represented by 25% and 100% WRC, represent stress conditions for the species. Water availability causes a high activity of antioxidant enzymes (superoxide dismutase, peroxidase, and catalase) in the plant.

  7. Project to promote the development of global environmental industry technology. Feasibility study of research exchanges; Chikyu kankyo sangyo gijutsu kaihatsu suishin jigyo. Kenkyu koryu kanosei chosa

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-03-01

    In fiscal 1995, three teams were organized to study the following subjects: plant genetic and cellular engineering in relation to drought stress; simulation models of global environment for accurate assessment and prediction; the APEC Virtual Center for environmental technology exchange. The team studying plant genetic and cellular engineering in relation to drought stress visited the Department of Botany, Hebrew University of Jerusalem, Israel, the Jacob Blaustein Institute for Desert Research, Ben-Grunion University, Israel, the Department of Biochemistry and the Office of Arid Lands Studies, Arizona University, the U.S. to survey the present and future trend of the study and feasibility of research exchanges. The team studying simulation models of global environment for accurate assessment and prediction visited Yale University, Massachusetts Institute of Technology, Electric Power Research Institute, and Battle Research Institute in the U.S. to survey feasibility of research exchanges. The team studying the APEC Virtual Center for environmental technology exchange visited institutes in ASEAN countries to survey needs for the Virtual Center. 312 refs., 74 figs., 17 tabs.

  8. Influence of ambient temperature and minute ventilation on passive and active heat and moisture exchangers.

    Science.gov (United States)

    Lellouche, François; Qader, Siham; Taillé, Solenne; Lyazidi, Aissam; Brochard, Laurent

    2014-05-01

    During invasive mechanical ventilation, inspired gases must be humidified. We previously showed that high ambient temperature greatly impaired the hygrometric performance of heated wire-heated humidifiers. The aim of this bench and clinical study was to assess the humidification performance of passive and active heat and moisture exchangers (HMEs) and the impact of ambient temperature and ventilator settings. We first tested on the bench a device with passive and active humidification properties (Humid-Heat, Teleflex), and 2 passive hydrophobic/hygroscopic HMEs (Hygrobac and Hygrobac S, Tyco Healthcare). The devices were tested at 3 different ambient temperatures (from 22 to 30 °C), and at 2 minute ventilation settings (10 and 20 L/min). Inspired gas hygrometry was measured at the Y-piece with the psychrometric method. In addition to the bench study, we measured the hygrometry of inspired gases in 2 different clinical studies. In 15 mechanically ventilated patients, we evaluated Humid-Heat at different settings. Additionally, we evaluated Humid-Heat and compared it with Hygrobac in a crossover study in 10 patients. On the bench, with the Hygrobac and Hygrobac S the inspired absolute humidity was ∼ 30 mg H2O/L, and with the Humid-Heat, slightly Heat provided inspired humidity in a range from 28.5 to 42.0 mg H2O/L, depending on settings, and was only weakly influenced by the patient's body temperature. In this study both passive and active HMEs had stable humidification performance with negligible influence of ambient temperature and minute ventilation. This contrasts with previous findings with heated wire-heated humidifiers. Although there are no clear data demonstrating that higher humidification impacts outcomes, it is worth noting that humidity was significantly higher with the active HME.

  9. Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides on p21ras

    NARCIS (Netherlands)

    Medema, R.H.; Vries-Smits, A.M. de; Zon, G.C.M. van der; Maassen, J.A.; Bos, J.L.

    1993-01-01

    A number of growth factors, including insulin and epidermal growth factor (EGF), induce accumulation of the GTP-bound form of p21ras. This accumulation could be caused either by an increase in guanine nucleotide exchange on p21ras or by a decrease in the GTPase activity of p21ras. To investigate

  10. Skype-Based English Activities: A Case for Compelling Input? Correlational Changes before and after Skype Exchanges

    Science.gov (United States)

    Ockert, David

    2015-01-01

    This paper reports the results of a small, longitudinal study involving a group of Japanese elementary school students (N = 29) involved in exploratory research using foreign language activities, including two Skype exchanges between these students and students in Australia. The purpose of the research was to test for the impact of a series of…

  11. Diurnal and seasonal variation in air exchange rates and interzonal flows measured by active tracer gas in five Danish homes

    DEFF Research Database (Denmark)

    Clausen, Geo; Bekö, Gabriel; Toftum, Jørn

    2016-01-01

    We measured the air exchange rates (AER) in up to six rooms in five naturally ventilated dwellings across four seasons using active tracer gas. Night time AER was also estimated in all bedrooms based on occupant-generated CO2. Additionally, we studied the pollutant distribution across the dwellings...

  12. Coordinating technology introduction and entrepreneurial activities in rural areas

    NARCIS (Netherlands)

    Fokkema, J.E.; Pennink, B.J.W.; Simatupang, T.M.

    2017-01-01

    © Copyright 2017 Inderscience Enterprises Ltd. The main purpose of this research is to investigate how technology introduction projects in rural areas should be coordinated in order to achieve local economic development and the role of social capital and entrepreneurial activities. Characteristics

  13. Learner-Interface Interaction for Technology-Enhanced Active Learning

    Science.gov (United States)

    Sinha, Neelu; Khreisat, Laila; Sharma, Kiron

    2009-01-01

    Neelu Sinha, Laila Khreisat, and Kiron Sharma describe how learner-interface interaction promotes active learning in computer science education. In a pilot study using technology that combines DyKnow software with a hardware platform of pen-enabled HP Tablet notebook computers, Sinha, Khreisat, and Sharma created dynamic learning environments by…

  14. Office of Biological Informatics and Outreach geospatial technology activities

    Science.gov (United States)

    ,

    1998-01-01

    The U.S. Geological Survey (USGS) Office of Biological Informatics and Outreach (OBIO) in Reston, Virginia, and its Center for Biological Informatics (CBI) in Denver, Colorado, provide leadership in the development and use of geospatial technologies to advance the Nation's biological science activities.

  15. Conformational changes in Akt1 activation probed by amide hydrogen/deuterium exchange and nano-electrospray ionization mass spectrometry†

    Science.gov (United States)

    Guo, Mingquan; Huang, Bill X.; Kim, Hee-Yong

    2009-01-01

    Amide hydrogen exchange coupled to nano-electrospray ionization mass spectrometry (nano-ESI-MS) has been used to identify and characterize localized conformational changes of Akt upon activation. Active or inactive Akt was incubated in D2O buffer, digested with pepsin, and analyzed by nano-ESI-MS to determine the deuterium incorporation. The hydrogen/deuterium (H/D) exchange profiles revealed that Akt undergoes considerable conformational changes in the core structures of all three individual domains after activation. In the PH domain, four β-strand (β1, β2 β5 and β6) regions containing membrane-binding residues displayed higher solvent accessibility in the inactive state, suggesting that the PH domain is readily available for the binding to the plasma membrane for activation. In contrast, these β-strands became less exposed or more folded in the active form, which is favored for the dissociation of Akt from the membrane. The beginning α-helix J region and the C-terminal locus (T450-470P) of the regulatory domain showed less folded structures that probably enable substrate entry. Our data also revealed detailed conformational changes of Akt in the kinase domain due to activation, some of which may be attributed to the interaction of the basic residues with phosphorylation sites. Our H/D exchange results indicating the conformational status of Akt at different activation states provided new insight for the regulation of this critical protein involved in cell survival. PMID:19462409

  16. Effect of NSAIDs on Na⁺/H⁺ exchanger activity in rat colonic crypts.

    Science.gov (United States)

    Roginiel, Aliya C; Kohut, Daniel L; Kaur, Sumanpreet; Saleh, Ahmad M A; Weber, Theresa; Geibel, Peter; Singh, Harmeet; Geibel, John P

    2013-09-01

    Nonsteroidal anti-inflammatory drugs (NSAIDs; 1) are widely recommended for several acute and chronic conditions. For example, both indomethacin and aspirin are taken for pain relief. Aspirin is also used for prevention of myocardial infarction, and indomethacin can be administered orally or as a suppository for patients with rheumatoid disease and other chronic inflammatory states. However, use of NSAIDs can cause damage to the mucosal barrier surrounding the gastrointestinal (GI) tract, increasing the risk of ulcer formation. While microencapsulation of NSAIDs has been shown to reduce upper GI injury, sustained release in the lower GI tract and colon may cause epithelial erosion due to increased acidification. The use of suppositories has also been linked to rectal and lower GI bleeding. In this study, we investigated the role of NSAIDs aspirin and indomethacin on Na⁺/H⁺ exchanger (NHE) activity in rat colonic crypts. By comparing average rates of pH recovery between control and NSAID perfusion runs, we were able to determine that both aspirin and indomethacin increase hydrogen extrusion into the colonic lumen. Through treatment with 5-ethylisopropyl amiloride (EIPA), amiloride, and zoniporide dihydrochloride, we further demonstrated that indomethacin specifically enhances proton excretion through regulation of apical NHE-3 and NHE-2 and to a lesser extent on basolateral NHE-1 and NHE-4. Our results suggest that clinical exposure to NSAIDs may affect colonic tissue at the site of selected NHE isoforms, resulting in modulation of transport and barrier function.

  17. Perchlorate adsorption and desorption on activated carbon and anion exchange resin.

    Science.gov (United States)

    Yoon, In-Ho; Meng, Xiaoguang; Wang, Chao; Kim, Kyoung-Woong; Bang, Sunbaek; Choe, Eunyoung; Lippincott, Lee

    2009-05-15

    The mechanisms of perchlorate adsorption on activated carbon (AC) and anion exchange resin (SR-7 resin) were investigated using Raman, FTIR, and zeta potential analyses. Batch adsorption and desorption results demonstrated that the adsorption of perchlorate by AC and SR-7 resin was reversible. The reversibility of perchlorate adsorption by the resin was also proved by column regeneration test. Solution pH significantly affected perchlorate adsorption and the zeta potential of AC, while it did not influence perchlorate adsorption and the zeta potential of resin. Zeta potential measurements showed that perchlorate was adsorbed on the negatively charged AC surface. Raman spectra indicated the adsorption resulted in an obvious position shift of the perchlorate peak, suggesting that perchlorate was associated with functional groups on AC at neutral pH through interactions stronger than electrostatic interaction. The adsorbed perchlorate on the resin exhibited a Raman peak at similar position as the aqueous perchlorate, indicating that perchlorate was adsorbed on the resin through electrostatic attraction between the anion and positively charged surface sites.

  18. Exchange of dose data within nuclear activities in Finland and Sweden

    International Nuclear Information System (INIS)

    Vilkamo, O.; Malmqvist, L.

    1988-01-01

    In the Nordic countries, Denmark, Finland, Iceland, Norway and Sweden, only Sweden and Finland have introduced nuclear power into energy production. The first still operating nuclear power plant was commissioned in Sweden in 1972 and in Finland in 1977. It was soon noticed that there was a growing tendency that small groups of workers used to move at short notice between Finland and Sweden to work in the nuclear power plants in both countries during maintenance periods. In 1983, the regulatory authorities for radiation protection, National Institute of Radiation Protection in Sweden and Finnish Centre for Radiation and Nuclear Safety in Finland, surveyed the radiation exposure to those workers. The authorities have brought about an arrangement by means of which the central dose data bases in the other country since 1984 have been able to record without delay the radiation doses received by her own citizens in the nuclear power plants of the neighbouring country. In addition, the authorities have confirmed the procedures of controlling dose data on workers from the neighbouring country, before those workers start working in a nuclear power plant regulated by the national authorities in question. The paper describes the starting point of the activity, the established practice and the experience achieved. Until now, the practical experiences are positive. The total radiation exposure to the workers in the Swedish and Finnish nuclear power plants has been relatively low at each plant site. Thus, the main objective in the exchange of dose data, is to achieve a good radiation protection control

  19. Technology in College Unions and Student Activities: A Collection of Technology Resources from the ACUI Community

    Science.gov (United States)

    Association of College Unions International (NJ1), 2012

    2012-01-01

    This publication presents a collection of technology resources from the Association of College Unions International (ACUI) community. Contents include: (1) Podcasting (Jeff Lail); (2) Video Podcasting (Ed Cabellon); (3) Building a Multimedia Production Center (Nathan Byrer); (4) Cloud Computing in the Student Union and Student Activities (TJ…

  20. Cu2Se and Cu Nanocrystals as Local Sources of Copper in Thermally Activated In Situ Cation Exchange

    KAUST Repository

    Casu, Alberto

    2016-01-27

    Among the different synthesis approaches to colloidal nanocrystals a recently developed toolkit is represented by cation exchange reactions, where the use of template nanocrystals gives access to materials that would be hardly attainable via direct synthesis. Besides, post-synthetic treatments, such as thermally activated solid state reactions, represent a further flourishing route to promote finely controlled cation exchange. Here, we report that, upon in situ heating in a transmission electron microscope, Cu2Se nanocrystals deposited on an amorphous solid substrate undergo partial loss of Cu atoms, which are then engaged in local cation exchange reactions with Cu “acceptors” phases represented by rod- and wire- shaped CdSe nanocrystals. This thermal treatment slowly transforms the initial CdSe nanocrystals into Cu2-xSe nanocrystals, through the complete sublimation of Cd and the partial sublimation of Se atoms. Both Cu “donor” and “acceptor” particles were not always in direct contact with each other, hence the gradual transfer of Cu species from Cu2Se or metallic Cu to CdSe nanocrystals was mediated by the substrate and depended on the distance between the donor and acceptor nanostructures. Differently from what happens in the comparably faster cation exchange reactions performed in liquid solution, this study shows that slow cation exchange reactions can be performed at the solid state, and helps to shed light on the intermediate steps involved in such reactions.

  1. Active fiber optic technologies used as tamper-indicating devices

    International Nuclear Information System (INIS)

    Horton, P.R.V.; Waddoups, I.G.

    1995-11-01

    The Sandia National Laboratories (SNL) Safeguards and Seals Evaluation Program is evaluating new fiber optic active seal technologies for use at Department of Energy (DOE) facilities. The goal of the program is to investigate active seal technologies that can monitor secured containers storing special nuclear materials (SNM) within DOE vaults. Specifically investigated were active seal technologies that can be used as tamper-indicating devices to monitor secured containers within vaults while personnel remain outside the vault area. Such a system would allow minimal access into vaults while ensuring container content accountability. The purpose of this report is to discuss tamper-indicating devices that were evaluated for possible DOE use. While previous seal evaluations (Phase I and II) considered overall facility applications, this discussion focuses specifically on their use in vault storage situations. The report will highlight general background information, specifications and requirements, and test procedures. Also discussed are the systems available from four manufacturers: Interactive Technologies, Inc., Fiber SenSys, Inc., Inovonics, Inc., and Valve Security Systems

  2. Active RFID Technology for Asset Tracking and Management System

    Directory of Open Access Journals (Sweden)

    Tharek Abdul Rahman

    2013-03-01

    Full Text Available Asset is one of valuable item in the industry or institution, missing or lose of asset may have problem in asset management system. The advantages of Radio Frequency Identification (RFID technology have made this technology useful for asset management and tracking system. The use of active RFID technology for asset tracking is by attaching the tag at the asset or item with assigned a unique ID for identification. A few of active RFID readers install at strategic points or location to track asset movement and collect information when anyone of item pass by in reader coverage area, reader collect information with in reading range and send to backend system. Integration every single system by using wires or wireless methods to keep centralize data processing system. Alert message will be send to representative department to give warning. This asset tracking and management system that use active type of RFID technology is working at ISM band frequency of 433 MHz. The backend systems consist of application software, middleware and database. All the information have been sent from every single system recorded in one central database.

  3. Toshiba's activity concerning technology succession and human resource development

    International Nuclear Information System (INIS)

    Ogura, Kenji; Hoshide, Akehiko

    2008-01-01

    Recently, from the viewpoint of the reduction of carbon-dioxide emission that cause global warming and the energy security, the importance of nuclear power generation is recognized again as an effective approach for solving the problems, and many nuclear power plants are planed to be constructed worldwide. On the other hand, the experienced engineers will face the time of the retirement in the near future and technology succession and human resource development has become important problems. In this paper, Toshiba's Nuclear Energy Systems and Services Division's activity concerning technology succession and human resource development will be introduced. (author)

  4. The activities of HPPA technology related to ADS in China

    CERN Document Server

    Guan Xia Ling; Ding Da Zhao; Fang Jia Xun; Fang Shou Xian; Fu Shin Ian; Guo, Z Y; Jiang Wei; Li Jie Quan; Luo Zi Hua; Ouyang Hua Fu; Peng Chao Hua; Xu Tao Guang; Xu Wen Wu; Yu Qi; Zhang Zong Hua; Zhao Sheng Chu

    2001-01-01

    High Power Proton Accelerator (HPPA) is being studied all over world for numerous applications, which includes the waste transmutation, spallation neutron source and material irradiation facilities. In China, a multi-purpose verification system as a first phase of Chinese ADS program consists of a low energy accelerator (150 MeV/3 mA proton linac) and a swimming pool light water sub-critical reactor. The activities of HPPA technology related to ADS in China, which includes the intense proton ECR source, the RFQ accelerator and some other technology of HPPA, are described

  5. Enhanced Ca(2+)-activated Na(+)-Ca(2+) exchange activity in canine pacing-induced heart failure.

    Science.gov (United States)

    Hobai, I A; O'Rourke, B

    2000-10-13

    Defective excitation-contraction coupling in heart failure is generally associated with both a reduction in sarcoplasmic reticulum (SR) Ca(2+) uptake and a greater dependence on transsarcolemmal Na(+)-Ca(2+) exchange (NCX) for Ca(2+) removal. Although a relative increase in NCX is expected when SR function is impaired, few and contradictory studies have addressed whether there is an absolute increase in NCX activity. The present study examines in detail NCX density and function in left ventricular midmyocardial myocytes isolated from normal or tachycardic pacing-induced failing canine hearts. No change of NCX current density was evident in myocytes from failing hearts when intracellular Ca(2+) ([Ca(2+)](i)) was buffered to 200 nmol/L. However, when [Ca(2+)](i) was minimally buffered with 50 micromol/L indo-1, Ca(2+) extrusion via NCX during caffeine application was doubled in failing versus normal cells. In other voltage-clamp experiments in which SR uptake was blocked with thapsigargin, both reverse-mode and forward-mode NCX currents and Ca(2+) transport were increased >2-fold in failing cells. These results suggest that, in addition to a relative increase in NCX function as a consequence of defective SR Ca(2+) uptake, there is an absolute increase in NCX function that depends on [Ca(2+)](i) in the failing heart.

  6. Geography of community health information organization activity in the United States: Implications for the effectiveness of health information exchange.

    Science.gov (United States)

    Vest, Joshua R

    The United States has invested nearly a billion dollars in creating community health information organizations (HIOs) to foster health information exchange. Community HIOs provide exchange services to health care organizations within a distinct geographic area. While geography is a key organizing principle for community HIOs, it is unclear if geography is an effective method for organization or what challenges are created by a geography-based approach to health information exchange. This study describes the extent of reported community HIO coverage in the United States and explores the practical and policy implications of overlaps and gaps in HIO service areas. Furthermore, because self-reported service areas may not accurately reflect the true extent of HIOs activities, this study maps the actual markets for health services included in each HIO. An inventory of operational community HIOs that included self-reported geographic markets and participating organizations was face-validated using a crowd-sourcing approach. Aggregation of the participating hospitals' individual health care markets provided the total geographic market served by each community HIO. Mapping and overlay analyses using geographic information system methods described the extent of community HIO activity in the United States. Evidence suggests that community HIOs may be inefficiently distributed. Parts of the United States have multiple, overlapping HIOs, while others do not have any providing health information exchange services. In markets served by multiple community HIOs, 45% of hospitals were participants of only one HIO. The current geography of community HIO activity does not provide comprehensive patient information to providers, nor community-wide information for public health agencies. The discord between the self-reported and market geography of community HIOs raises concerns about the potential effectiveness of health information exchange, illustrates the limitations of geography as

  7. Dynamic positioning system based on active disturbance rejection technology

    Science.gov (United States)

    Lei, Zhengling; Guo, Chen; Fan, Yunsheng

    2015-08-01

    A dynamically positioned vessel, by the International Maritime Organization (IMO) and the certifying class societies (DNV, ABS, LR, etc.), is defined as a vessel that maintains its position and heading (fixed location or pre-determined track) exclusively by means of active thrusters. The development of control technology promotes the upgrading of dynamic positioning (DP) systems. Today there are two different DP systems solutions available on the market: DP system based on PID regulator and that based on model-based control. Both systems have limited disturbance rejection capability due to their design principle. In this paper, a new DP system solution is proposed based on Active Disturbance Rejection Control (ADRC) technology. This technology is composed of Tracking-Differentiator (TD), Extended State Observer (ESO) and Nonlinear Feedback Combination. On one hand, both TD and ESO can act as filters and can be used in place of conventional filters; on the other hand, the total disturbance of the system can be estimated and compensated by ESO, which therefore enhances the system's disturbance rejection capability. This technology's advantages over other methods lie in two aspects: 1) This method itself can not only achieve control objectives but also filter noisy measurements without other specialized filters; 2) This method offers a new useful approach to suppress the ocean disturbance. The simulation results demonstrate the effectiveness of the proposed method.

  8. Understanding active and passive users: the effects of an active user using normal, hard and unreliable technologies on user assessment of trust in technology and co-user.

    Science.gov (United States)

    Montague, Enid; Xu, Jie

    2012-07-01

    The aim of this study was to understand how passive users perceive the trustworthiness of active users and technologies under varying technological conditions. An experimental study was designed to vary the functioning of technologies that active users interacted with, while passive users observed these interactions. Active and passive user ratings of technology and partner were collected. Exploratory data analysis suggests that passive users developed perceptions of technologies based on the functioning of the technology and how the active user interacted with the technology. Findings from this research have implications for the design of technologies in environments where active and passive users interact with technologies in different ways. Future work in this area should explore interventions that lead to enhanced affective engagement and trust calibration. Published by Elsevier Ltd.

  9. Understanding Active and Passive Users: The Effects of an Active User Using Normal, Hard and Unreliable Technologies on User Assessment of Trust in Technology and Co-User

    Science.gov (United States)

    Montague, Enid; JieXu

    2011-01-01

    The aim of this study was to understand how passive users perceive the trustworthiness of active users and technologies under varying technological conditions. An experimental study was designed to vary the functioning of technologies that active users interacted with, while passive users observed these interactions. Active and passive user ratings of technology and partner were collected. Exploratory data analysis suggests that passive users developed perceptions of technologies based on the functioning of the technology and how the active user interacted with the technologies. Findings from this research have implications for the design of technologies in environments where active and passive users interact with technologies in different ways. Future work in this area should explore interventions that lead to enhanced affective engagement and trust calibration. PMID:22192788

  10. Physical Activity in an Underserved Population: Identifying Technology Preferences.

    Science.gov (United States)

    Medairos, Robert; Kang, Vicky; Aboubakare, Carissa; Kramer, Matthew; Dugan, Sheila Ann

    2017-01-01

    This study aims to identify patterns of use and preferences related to technology platforms that could support physical activity (PA) programs in an underserved population. A 29-item questionnaire was administered at 5 health and wellness sites targeting low income communities in Chicago. Frequency tables were generated for Internet, cell phone, and social media use and preferences. Chi-squared analysis was used to evaluate differences across age and income groups. A total of 291 individuals participated and were predominantly female (69.0%). Majority reported incomes less than $30,000 (72.9%) and identified as African American/Black/Caribbean (49.3%) or Mexican/Mexican American (34.3%). Most participants regularly used smartphones (63.2%) and the Internet (75.9%). Respondents frequently used Facebook (84.8%), and less commonly used Instagram (43.6%), and Twitter (20.0%). Free Internet-based exercise programs were the most preferred method to increase PA levels (31.6%), while some respondents (21.0%) thought none of the surveyed technology applications would help. Cell phone, Internet, and social media use is common among the surveyed underserved population. Technology preferences to increase PA levels varied, with a considerable number of respondents not preferring the surveyed technology platforms. Creating educational opportunities to increase awareness may maximize the effectiveness of technology-based PA interventions.

  11. Designing Technology for Active Spectator Experiences at Sporting Events

    DEFF Research Database (Denmark)

    Veerasawmy, Rune; Ludvigsen, Martin

    2010-01-01

    is not merely an experience of receiving and consuming entertainment. It is also heavily reliant on the active participation of the spectator in creating the atmosphere of the entire event. The BannerBattle experiment provides interactive technology in sport arenas with a form of interaction based on existing......This paper explores the active spectator experience at sporting events, by presenting and reflecting upon a design experiment carried out at a number of football1 events. The initial hypothesis of the design process, leading to the design experiment has been that the spectator experience...... behaviour in the context. The work presented also argues for a need to overcome the inclination to designing technological systems that imitate or compete with the experience of watching the television broadcast of the game. Experiments such as the presented BannerBattle are cornerstones in our exploratory...

  12. Activation of ClpP protease by ADEP antibiotics: insights from hydrogen exchange mass spectrometry.

    Science.gov (United States)

    Sowole, Modupeola A; Alexopoulos, John A; Cheng, Yi-Qiang; Ortega, Joaquin; Konermann, Lars

    2013-11-15

    The bacterial protease ClpP consists of 14 subunits that assemble into two stacked heptameric rings. The central degradation chamber can be accessed via axial pores. In free ClpP, these pores are obstructed by the N-terminal regions of the seven subunits at either end of the barrel. Acyldepsipeptides (ADEPs) are antibacterial compounds that bind in hydrophobic clefts surrounding the pore region, causing the pores to open up. The ensuing uncontrolled degradation of intracellular proteins is responsible for the antibiotic activity of ADEPs. Recently published X-ray structures yielded conflicting models regarding the conformation adopted by the N-terminal regions in the open state. Here, we use hydrogen/deuterium exchange (HDX) mass spectrometry to obtain complementary insights into the ClpP behavior with and without ADEP1. Ligand binding causes rigidification of the equatorial belt, accompanied by destabilization in the vicinity of the binding clefts. The N-terminal regions undergo rapid deuteration with only minor changes after ADEP1 binding, revealing a lack of stable H-bonding. Our data point to a mechanism where the pore opening mechanism is mediated primarily by changes in the packing of N-terminal nonpolar side chains. We propose that a "hydrophobic plug" causes pore blockage in ligand-free ClpP. ADEP1 binding provides new hydrophobic anchor points that nonpolar N-terminal residues can interact with. In this way, ADEP1 triggers the transition to an open conformation, where nonpolar moieties are clustered around the rim of the pore. This proposed mechanism helps reconcile the conflicting models that had been put forward earlier. © 2013.

  13. Summary of pilot-scale activities with resorcinol ion exchange resin

    Energy Technology Data Exchange (ETDEWEB)

    Cicero, C.A. [Westinghouse Savannah River Company, AIKEN, SC (United States); Bickford, D.F.; Sargent, T.N.; Andrews, M.K.; Bibler, J.P.; Bibler, N.E.; Jantzen, C.M.

    1995-10-02

    The Mixed Waste Focus Area (MWFA) of the Department of Energy (DOE) is currently investigating vitrification technology for treatment of low level mixed wastes (LLMW). They have chartered the Savannah River Technology Center (SRTC) to study vitrification of the wastes through an Office of Technology Development (OTD) Technical Task Plan (TTP). SRTC`s efforts have included crucible-scale studies and pilot scale testing on simulated LLMW sludges, resins, soils, and other solid wastes. Results from the crucible-scale studies have been used as the basis for the pilot-scale demonstrations. As part of the fiscal year (FY) 1995 activities, SRTC performed crucible-scale studies with organic resins. This waste stream was selected because of the large number of DOE sites, as well as commercial industries, that use resins for treatment of liquid wastes. Pilot-scale studies were to be completed in FY 1995, but could not be due to a reduction in funding. Instead, a compilation of pilot-scale tests with organic resins performed under the guidance of SRTC was provided in this report. The studies which will be discussed used a resorcinol- formaldehyde resin loaded with non-radioactive cesium, which was fed with simulated wastewater treatment sludge feed. The first study was performed at the SRTC in the mini-melter, 1/100th scale of the Defense Waste Processing Facility (DWPF) melter, and also involved limited crucible-scale studies to determine the resin loading obtainable. The other study was performed at the DOE/Industrial Center for Vitrification Research (Center) and involved both crucible and pilot-scale testing in the Stir-Melter stirred-melter. Both studies were successful in vitrifying the resin in simulated radioactive sludge and glass additive feeds.

  14. Peer exchange May 3-5, 2016 : Alaska Department of Transportation and Public Facilities : research development & technology transfer.

    Science.gov (United States)

    2016-01-01

    Members of the Peer Exchange Team identified actions Alaska should consider to : improve effectiveness of the research program: : 1. Conduct Research Strategic Visioning Workshop with Staff and Research : Advisory Board in Fall, 2016 : 2. Develop a T...

  15. Storytelling: a care technology in continuing education for active ageing.

    Science.gov (United States)

    Costa, Nadia Pinheiro da; Polaro, Sandra Helena Isse; Vahl, Eloá Aparecida Caliari; Gonçalves, Lucia Hisako Takase

    2016-01-01

    assessing relevance and effectiveness of care/educational technology in the form of "storytelling" as a strategy in the cultivation of active ageing (AA) for elderly users of a Basic Health Unit (BHU), from the Amazon region. convergent care research (CCR) held in a BHU in Belém, state of Pará, with eight elderly ladies for testing this technology. An active ageing assessment questionnaire and WHOQOL-BREF - quality of life assessment were applied. After training with a view to continuing education, elderly ladies told stories for an audience that addressed the question: "What did you learn from it for your life?" tThe popular stories elicited reactions from which the following categories emerged: solidarity; respect for the other; imagination, dreams, hopes and culture of the Amazonian. This practice had a positive result, producing changes in the quality of life of the elderly, particularly in the psychological domain. "storytelling" proved to be an innovative technology, a relevant and effective resource in health education, especially for active ageing.

  16. Designing Technology for Active Spectator Experiences at Sporting Events

    DEFF Research Database (Denmark)

    Veerasawmy, Rune; Ludvigsen, Martin

    This paper explores the active spectator experience at sporting events, by presenting and reflecting upon a design experiment carried out at a number of football1 events. The initial hypothesis of the design process, leading to the design experiment has been that the spectator experience...... is not merely an experience of receiving and consuming entertainment. It is also heavily reliant on the active participation of the spectator in creating the atmosphere of the entire event. The BannerBattle experiment provides interactive technology in sport arenas with a form of interaction based on existing...

  17. Designing Technology for Active Spectator Experiences at Sporting Events

    DEFF Research Database (Denmark)

    Ludvigsen, Martin; Veerasawmy, Rune

    2010-01-01

    This paper explores the active spectator experience at sporting events, by presenting and reflecting upon a design experiment carried out at a number of football1 events. The initial hypothesis of the design process, leading to the design experiment has been that the spectator experience...... is not merely an experience of receiving and consuming entertainment. It is also heavily reliant on the active participation of the spectator in creating the atmosphere of the entire event. The BannerBattle experiment provides interactive technology in sport arenas with a form of interaction based on existing...

  18. Impact of active controls technology on structural integrity

    Science.gov (United States)

    Noll, Thomas; Austin, Edward; Donley, Shawn; Graham, George; Harris, Terry

    1991-01-01

    This paper summarizes the findings of The Technical Cooperation Program to assess the impact of active controls technology on the structural integrity of aeronautical vehicles and to evaluate the present state-of-the-art for predicting the loads caused by a flight-control system modification and the resulting change in the fatigue life of the flight vehicle. The potential for active controls to adversely affect structural integrity is described, and load predictions obtained using two state-of-the-art analytical methods are given.

  19. Progress report on scientific and technological activities: 1995

    International Nuclear Information System (INIS)

    1996-01-01

    An overview of research and development activities of the Constituyentes Atomic Center, National Atomic Energy Commission (Argentine), during the period January-December 1995 is presented. The research and development activities are reported under the following headings: Fuel Elements; Non Destructive and Structural Test; Physics; Materials; Chemistry; Radiobiology Nuclear Reactors; Institute of Technology; Quality Management; Technical Assistance to Industry (SATI); Computer and Communication Services Center; Nuclear Power Stations Support Group. List of publications by the scientific staff of the Atomic Center is provided. The list includes paper published in journals, papers presented in conferences, symposia, etc., and technical reports

  20. Progress report on scientific and technological activities: 1996

    International Nuclear Information System (INIS)

    1997-01-01

    An overview of research and development activities of the Constituyentes Atomic Center, National Atomic Energy Commission (Argentine), during the period January-December 1996 is presented. The research and development activities are reported under the following headings: Fuel Elements; Non Destructive and Structural Test; Physics; Materials; Chemistry; Radiobiology Nuclear Reactors; Institute of Technology; Quality Management; Technical Assistance to Industry (SATI); Computer and Communication Services Center; Nuclear Power Stations Support Group. List of publications by the scientific staff of the Atomic Center is provided. The list includes paper published in journals, papers presented in conferences, symposia, etc., and technical reports

  1. Dissecting the mechanism of Epac activation via hydrogen-deuterium exchange FT-IR and structural modeling.

    Science.gov (United States)

    Yu, Shaoning; Fan, Fenghui; Flores, Samuel C; Mei, Fang; Cheng, Xiaodong

    2006-12-26

    Exchange proteins directly activated by cAMP (Epac) make up a family of cAMP binding domain-containing proteins that play important roles in mediating the effects of cAMP through the activation of downstream small GTPases, Ras-proximate proteins. To delineate the mechanism of Epac activation, we probed the conformation and structural dynamics of Epac using amide hydrogen-deuterium (H-D) exchange coupled with Fourier transform infrared spectroscopy (FT-IR) and structural modeling. Our studies show that unlike that of cAMP-dependent protein kinase (PKA), the classic intracellular cAMP receptor, binding of cAMP to Epac does not induce significant changes in overall secondary structure and structural dynamics, as measured by FT-IR and the rate of H-D exchange, respectively. These results suggest that Epac activation does not involve significant changes in the amount of exposed surface areas as in the case of PKA activation, and conformational changes induced by cAMP in Epac are most likely confined to small local regions. Homology modeling and comparative structural analyses of the CBDs of Epac and PKA lead us to propose a model of Epac activation. On the basis of our model, Epac activation by cAMP employs the same underlying structural principal utilized by PKA, although the detailed structural and conformational changes associated with Epac and PKA activation are significantly different. In addition, we predict that during Epac activation the first beta-strand of the switchboard switches its conformation to a alpha-helix, which folds back to the beta-barrel core of the CBD and interacts directly with cAMP to form the base of the cAMP-binding pocket.

  2. Pre-departure preparation and co-curricular activities for Students' intercultural exchange: A mixed-methods study.

    Science.gov (United States)

    Chan, E Angela; Liu, Justina Yat Wa; Fung, Keith Hin Kee; Tsang, Pak Lik; Yuen, John

    2018-04-01

    Nurses are required to be culturally competent to provide quality care to an increasingly diverse and ageing population. International exchange programmes were developed to support the traditional nursing curriculum. These programmes have often overlooked the importance of pre-departure preparation and co-curricular activities to the development of intercultural competency. To explore the influence of pre-departure and co-curricular activities on the intercultural learning experiences of both exchange and host students in a short-term international summer programme. A mixed-methods study. Students were recruited from international and mainland exchange partners, with host students as ambassadors. The international summer programme involved a week of online pre-departure activities and two weeks of face-to-face meetings. A convenience sample of 62 students from diverse cultural backgrounds was recruited on a voluntary basis. The participants were aged between 19 and 27. Data were collected from students' pre- and post-visit questionnaires, discussions within the workshops, their online discussion threads, and focus group discussions. The quantitative findings suggested that students' cultural intelligence improved significantly after the exchange programme. Qualitatively, three themes emerged as: 1) Students' motivation to engage in intercultural learning; 2) Barriers to intercultural communication; 3) Enablers of intercultural communication. Pre-departure preparation enabled students to discuss their common goals and expectations, while exploring differences, asked for practical living information, and used the basic intercultural concepts in their discussion on the care of elderly. This virtual encounter has lay the foundation for students' subsequent discussions about the why and how the differences that inform their own practices and about global ageing and poverty issues during their co-curricular activities. While the pre-departure preparation could serve as a

  3. Panel on increasing the visibility and publicity for data activities and assuring the open exchange of data

    International Nuclear Information System (INIS)

    Schultz, D.R.

    1998-01-01

    This panel was charged with leading and stimulating discussion regarding two principal issues: (1) the need to increase the visibility of atomic data production and collection activities in recognition of their role as vitally important resources for diverse applications, and (2) the need to assure the open exchange of this data. Comments by the panelists, supplemented by interaction with the audience, are summarized here along with the principal conclusions

  4. Hydrogen/Deuterium Exchange Mass Spectrometry Reveals Mechanistic Details of Activation of Nucleoside Diphosphate Kinases by Oligomerization

    OpenAIRE

    Dautant , Alain; Meyer , Philippe; Georgescauld , Florian

    2017-01-01

    International audience; Most oligomeric proteins become active only after assembly, but why oligomerization is required to support function is not well understood. Here, we address this question using the WT and a destabilized mutant (D93N) of the hexameric nucleoside diphosphate kinase from the pathogen Mycobacterium tuberculosis (Mt-NDPK). The conformational dynamics and oligomeric states of each were analyzed during unfolding/folding by Hydrogen/Deuterium exchange mass spectrometry (HDX-MS...

  5. Pre-commissioning activities of exchange units of Heavy Water Plant, Manuguru (Paper No. 1.2)

    International Nuclear Information System (INIS)

    Kamath, H.S.; Sikaria, R.P.

    1992-01-01

    Heavy Water Plant, Manuguru (HWPM) comprises of two exchange units where enrichment of deuterium from natural concentration to 15% concentration is achieved using dual temperature H 2 S-H 2 O exchange process in a three stage cascade. In each exchange unit an inventory of around 200 MT of H 2 S gas is required under normal operating pressure and a feed water flow rate of 450 MT/Hr is required to be maintained. In view of the large flow rates of H 2 S circulating gas, water, cooling water, steam etc., the lines sizes in exchange unit are quite large. Further, H 2 S gas being highly toxic and corrosive, extreme care is required in order to ensure integrity and leak tightness. While due care is taken in material selection, design, quality surveillance etc., during fabrication, certain additional measures are required to be taken during precommissioning of the systems handling H 2 S under pressure. This paper deals with the activities from completion of plant erection including hydrotesting of piping by the piping contractor to the stage of trial production run. (author)

  6. Relations Between Morphology and Catalytic Activity of Ion Exchanger Catalysts for Synthesis of Bisphenol A

    Czech Academy of Sciences Publication Activity Database

    Jeřábek, Karel; Hanková, Libuše; Prokop, Zdeněk; Lundquist, E. G.

    2002-01-01

    Roč. 232, 1-2 (2002), s. 181-188 ISSN 0926-860X R&D Projects: GA ČR GA104/99/0125 Keywords : ion exchangers * catalyst * morphology Subject RIV: CI - Industrial Chemistry, Chemical Engineering Impact factor: 1.915, year: 2002

  7. Irreversible Catalyst Activation Enables Hyperpolarization and Water Solubility for NMR Signal Amplification by Reversible Exchange

    Science.gov (United States)

    2016-09-12

    M.; Chekmenev, E. Y. Temperature-Ramped 129Xe Spin Exchange Optical Pumping. Anal. Chem. 2014, 86, 8206−8212. (3) Kurhanewicz, J.; Vigneron, D. B...G. R.; Duckett, S. B.; Spiess, H. W.; Schreiber, L. M.; Münnemann, K. Continuous Proton Hyperpolarization Via SABRE and Hollow Fibre Membranes. Proc

  8. An Exchange Structure Analysis of the Development of Online Intercultural Activity

    Science.gov (United States)

    Kitade, Keiko

    2012-01-01

    Internet-mediated intercultural discussions have been adopted for intercultural and second-language learning. However, the notion of community development in this context has received less attention. This study employs exchange structure (ES) analysis (Stubbs, M. (1983). "Discourse analysis." Oxford: Basil Blackwell) to investigate the…

  9. Improving patient activity schedules by multi-agent Pareto appointment exchanging

    NARCIS (Netherlands)

    I.B. Vermeulen (Ivan); S.M. Bohte (Sander); D.J.A. Somefun (Koye); J.A. La Poutré (Han)

    2006-01-01

    textabstractWe present a dynamic and distributed approach to the hospital patient scheduling problem: the multi-agent Pareto-improvement appointment exchanging algorithm, MPAEX. It respects the decentralization of scheduling authorities and is capable of continuously adjusting the different patient

  10. Information technology -- Telecommunications and information exchange between systems -- Local and metropolitan area networks -- Specific requirements -- Part 9: Integrated Services (IS) LAN Interface at the Medium Access Control (MAC) and Physical (PHY) Layers

    CERN Document Server

    International Organization for Standardization. Geneva

    1996-01-01

    Information technology -- Telecommunications and information exchange between systems -- Local and metropolitan area networks -- Specific requirements -- Part 9: Integrated Services (IS) LAN Interface at the Medium Access Control (MAC) and Physical (PHY) Layers

  11. Chinese Commission of Science Technology and Industry for National Defense Senior Vice Minister CHEN Qiufa exchanging gifts at luncheon and signing the Guest Book on 1st November 2007 with CERN Director-General R. Aymar.

    CERN Multimedia

    Maximilien Brice

    2007-01-01

    Chinese Commission of Science Technology and Industry for National Defense Senior Vice Minister CHEN Qiufa exchanging gifts at luncheon and signing the Guest Book on 1st November 2007 with CERN Director-General R. Aymar.

  12. Development of long-lived radionuclide partitioning technology - Preparation of ion exchanges for selective separation of radioactive elements

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Si Joong; Jeong, Hae In; Shim, Min Sook [Korea University, Seoul (Korea, Republic of); Kim, Jeong [Seonam University, Namwon (Korea, Republic of)

    1995-07-01

    Ion exchanger contained nitrogen-oxygen donor macrocyclic units was synthesized, and immobilization process was carried out by adsorption of the exchanger to silica gel. The binding constants were measured with acid concentration. From the binding constants, selectivity for Pt(II) ion and acid concentration of eluents were determined. The most optimum conditions for the separation were also determined from investigating the effects of amount of immobile phase and column length. And liarit aza-crown ethers were synthesized and selectively separated Cs/Sr ion from mixed metal solution. 37= refs., 24 tabs., 40 figs. (author)

  13. Green” Technology and Ecologically Unequal Exchange: The Environmental and Social Consequences of Ecological Modernization in the World-System

    Directory of Open Access Journals (Sweden)

    Eric Bonds

    2015-08-01

    Full Text Available This paper contributes to understandings of ecologically unequal exchange within the world-systems perspective by offering a series of case studies of ecological modernization in the automobile industry. The case studies demonstrate that “green” technologies developed and instituted in core nations often require specific raw materials that are extracted from the periphery and semi-periphery. Extraction of such natural resources causes significant environmental degradation and often displaces entire communities from their land. Moreover, because states often use violence and repression to facilitate raw material extraction, the widespread commercialization of “green” technologies can result in serious human rights violations. These findings challenge ecological modernization theory, which rests on the assumption that the development and commercialization of more ecologically-efficient technologies is universally beneficial.

  14. Overview of DOE's field screening technology development activities

    International Nuclear Information System (INIS)

    Frank, C.W.; Anderson, T.D.; Cooley, C.R.; Hain, K.E.; Lien, S.C.T.; Erickson, M.D.

    1991-01-01

    The Department of Energy (DOE) has recently created the Office of Environmental Restoration and Waste Management, into which it consolidated those activities. Within this new organization, the Office of Technology Development (OTD) is responsible for research, development, demonstration, testing, and evaluation (RDDT ampersand E) activities aimed at meeting DOE cleanup goals, while minimizing cost and risk. Site characterization using traditional drilling, sampling, and analytical methods comprises a significant part of the environmental restoration efforts in terms of both cost and time to accomplish. It can also be invasive and create additional pathways for spread of contaminants. Consequently, DOE is focusing on site characterization as one of the areas in which significant technological advances are possible which will decrease cost, reduce risk, and shorten schedules for achieving restoration goals. DOE is investing considerably in R ampersand D and demonstration activities which will improve the abilities to screen chemical, radiological, and physical parameters in the field. This paper presents an overview of the program objectives and status and reviews some of the projects which are currently underway in the area. 1 ref

  15. Evaluation and Certification of Ambersorb 4652 for use in Activated Carbon Ion Exchange Filters for the International Space Station

    Science.gov (United States)

    Adam, Niklas; Cox, Trey; Larner, Katherine; Carter, Donald; Kouba, Coy

    2017-01-01

    In order to reduce the infiltration of dimethylsilanediol (DMSD) and other organosilicon containing species through the Multifiltration Beds (MF Beds), an alternate activated carbon was found to replace the obsolete Barnabey Cheney 580-26 activated carbon. The carbon that removed the most organosilicon compounds in testing1 was a synthetic activated carbon named Schunk 4652 which later became Ambersorb 4652. Since activated carbon has a large capacity for iodine (I2), and is used in the Activated Carbon Ion Exchange (ACTEX) filters on the International Space Station (ISS), testing was performed on the Ambersorb 4652 carbon to determine the effectiveness of the material for use in ACTEX filters to remove iodine. This work summarizes the testing and the certification of Ambersorb 4652 for use in the ACTEX filters for the ISS.

  16. Transcerebral exchange kinetics of nitrite and calcitonin gene-related peptide in acute mountain sickness: evidence against trigeminovascular activation?

    DEFF Research Database (Denmark)

    Bailey, Damian M; Taudorf, Sarah; Berg, Ronan M G

    2009-01-01

    BACKGROUND AND PURPOSE: High-altitude headache is the primary symptom associated with acute mountain sickness, which may be caused by nitric oxide-mediated activation of the trigeminovascular system. Therefore, the present study examined the effects of inspiratory hypoxia on the transcerebral...... exchange kinetics of the vasoactive molecules, nitrite (NO(2)(*)), and calcitonin gene-related peptide (CGRP). METHODS: Ten males were examined in normoxia and after 9-hour exposure to hypoxia (12.9% O(2)). Global cerebral blood flow was measured by the Kety-Schmidt technique with paired samples obtained...... from the radial artery and jugular venous bulb. Plasma CGRP and NO(2)(*) were analyzed via radioimmunoassay and ozone-based chemiluminescence. Net cerebral exchange was calculated by the Fick principle and acute mountain sickness/headache scores assessed via clinically validated questionnaires. RESULTS...

  17. Active Shop Scheduling Of Production Process Based On RFID Technology

    Directory of Open Access Journals (Sweden)

    Cuihua Chao

    2016-01-01

    Full Text Available In industry 4.0 environment, intelligent technology is almost applied to all parts of the manufacturing process, such as process design, job shop scheduling, etc.. This paper presents an efficient approach to job shop scheduling actively by using RFID to collect real-time manufacturing data. Identified the workpiece by RFID which needs to be machined, it can “ask for” the resource actively for the following process. With these active asking-for strategy, a double genetically encoded improved genetic algorithm is proposed for achieving active job shop scheduling solution during the actual manufacturing process. A case was used to evaluate its effectiveness. Meanwhile, , it can effectively and actively carry out job shop scheduling and has much better convergence effect comparing with basic genetic algorithm. And the job shop scheduler in management center can use the proposed algorithm to get the satisfied scheduling result timely by reducing waiting time and making begin time earlier during transmission between manufacturing process, which makes the scheduling result feasible and accurate.

  18. Development of HANARO Activation Analysis System and Utilization Technology

    International Nuclear Information System (INIS)

    Chung, Y. S.; Moon, J. H.; Cho, H. J.

    2007-06-01

    1. Establishment of evaluation system using a data for a neutron activation analysis : Improvement of NAA measurement system and its identification, Development of combined data evaluation code of NAA/PGAA, International technical cooperation project 2. Development of technique for a industrial application of high precision gamma nuclide spectroscopic analysis : Analytical quality control, Development of industrial application techniques and its identification 3. Industrial application research for a prompt gamma-ray activation analysis : Improvement of Compton suppression counting system (PGAA), Development of applied technology using a PGAA system 4. Establishment of NAA user supporting system and KOLAS management : Development and validation of KOLAS/ISO accreditation testing and identification method, Cooperation researches for a industrial application, Establishment of integrated user analytical supporting system, Accomplishment of sample irradiation facility

  19. The development of enabling technologies for producing active interrogation beams.

    Science.gov (United States)

    Kwan, Thomas J T; Morgado, Richard E; Wang, Tai-Sen F; Vodolaga, B; Terekhin, V; Onischenko, L M; Vorozhtsov, S B; Samsonov, E V; Vorozhtsov, A S; Alenitsky, Yu G; Perpelkin, E E; Glazov, A A; Novikov, D L; Parkhomchuk, V; Reva, V; Vostrikov, V; Mashinin, V A; Fedotov, S N; Minayev, S A

    2010-10-01

    A U.S./Russian collaboration of accelerator scientists was directed to the development of high averaged-current (∼1 mA) and high-quality (emittance ∼15 πmm mrad; energy spread ∼0.1%) 1.75 MeV proton beams to produce active interrogation beams that could be applied to counterterrorism. Several accelerator technologies were investigated. These included an electrostatic tandem accelerator of novel design, a compact cyclotron, and a storage ring with energy compensation and electron cooling. Production targets capable of withstanding the beam power levels were designed, fabricated, and tested. The cyclotron/storage-ring system was theoretically studied and computationally designed, and the electrostatic vacuum tandem accelerator at BINP was demonstrated for its potential in active interrogation of explosives and special nuclear materials.

  20. Development of HANARO Activation Analysis System and Utilization Technology

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Y. S.; Moon, J. H.; Cho, H. J. (and others)

    2007-06-15

    1. Establishment of evaluation system using a data for a neutron activation analysis : Improvement of NAA measurement system and its identification, Development of combined data evaluation code of NAA/PGAA, International technical cooperation project 2. Development of technique for a industrial application of high precision gamma nuclide spectroscopic analysis : Analytical quality control, Development of industrial application techniques and its identification 3. Industrial application research for a prompt gamma-ray activation analysis : Improvement of Compton suppression counting system (PGAA), Development of applied technology using a PGAA system 4. Establishment of NAA user supporting system and KOLAS management : Development and validation of KOLAS/ISO accreditation testing and identification method, Cooperation researches for a industrial application, Establishment of integrated user analytical supporting system, Accomplishment of sample irradiation facility.

  1. The Role of New Technology in Campus Activities: An Update for Professionals.

    Science.gov (United States)

    Greig, Rick E.

    1998-01-01

    A discussion of current uses of technology in campus activities programming looks at what is meant by "new technology"; the range of uses of technology in this field; the role and impact of the interactive aspects of information technology; how technology affects how professionals educate, advise, and train students; and dealing with students who…

  2. Treatment of low-activity-level process wastewaters by continuous countercurrent ion exchange

    International Nuclear Information System (INIS)

    Hall, R.; Watson, J.S.; Robinson, S.M.

    1990-01-01

    A mobile pilot-scale continuous countercurrent ion-exchange (CCIX) system is being operated at the Oak Ridge National Laboratory (ORNL) for the treatment of wastewaters that contain predominantly calcium sodium, and magnesium bicarbonates and are slightly contaminated with 90 Sr and 137 Cs radioisotopes. A demonstration study is being conducted to evaluate the near-steady-state performance and feasibility of a pilot-scale CCIX column for the selective removal of strontium from wastewater. Test results show that the process removes strontium sufficiently from the wastewater to permit discharge while significantly reducing the volume of secondary waste generation. CCIX has the potential for effective use in several applications; however, it has not been frequently utilized by industries to date. The CCIX system could offer an economical alternative for decontamination of wastewaters containing trace amounts of contaminants prior to discharge into the environment. This paper discusses (a) application of the Thomas model for predicting breakthrough curves from ion exchange column tests, (b) methods for scaleup of experimental small-scale ion-exchange columns to industrial-scale columns, and (c) methods for predicting effluent compositions in a CCIX system. 20 refs., 6 figs., 2 tabs

  3. Veterans’ Preferences for Exchanging Information Using Veterans Affairs Health Information Technologies: Focus Group Results and Modeling Simulations

    Science.gov (United States)

    Chavez, Margeaux; Nazi, Kim; Antinori, Nicole; Melillo, Christine; Cotner, Bridget A; Hathaway, Wendy; Cook, Ashley; Wilck, Nancy; Noonan, Abigail

    2017-01-01

    Background The Department of Veterans Affairs (VA) has multiple health information technology (HIT) resources for veterans to support their health care management. These include a patient portal, VetLink Kiosks, mobile apps, and telehealth services. The veteran patient population has a variety of needs and preferences that can inform current VA HIT redesign efforts to meet consumer needs. Objective This study aimed to describe veterans’ experiences using the current VA HIT and identify their vision for the future of an integrated VA HIT system. Methods Two rounds of focus group interviews were conducted with a single cohort of 47 veterans and one female caregiver recruited from Bedford, Massachusetts, and Tampa, Florida. Focus group interviews included simulation modeling activities and a self-administered survey. This study also used an expert panel group to provide data and input throughout the study process. High-fidelity, interactive simulations were created and used to facilitate collection of qualitative data. The simulations were developed based on system requirements, data collected through operational efforts, and participants' reported preferences for using VA HIT. Pairwise comparison activities of HIT resources were conducted with both focus groups and the expert panel. Rapid iterative content analysis was used to analyze qualitative data. Descriptive statistics summarized quantitative data. Results Data themes included (1) current use of VA HIT, (2) non-VA HIT use, and (3) preferences for future use of VA HIT. Data indicated that, although the Secure Messaging feature was often preferred, a full range of HIT options are needed. These data were then used to develop veteran-driven simulations that illustrate user needs and expectations when using a HIT system and services to access VA health care services. Conclusions Patient participant redesign processes present critical opportunities for creating a human-centered design. Veterans value virtual health

  4. Determination of iridium in the Bering Sea and Arctic Ocean seawaters by anion exchange preconcentration-neutron activation analysis

    International Nuclear Information System (INIS)

    Li Shihong; Mao Xueying; Chai Zhifang

    2004-01-01

    Anion exchange method is investigated to separate and enrich iridium in seawater by radiotracer 192 Ir. The adsorption of Ir in the resin increases with the decreasing acidity in the 0.05-1.2 mol/L HCl media, The recovery of iridium in pH=1.5 seawater reaches 89% by a single anion-exchange column. The polyethylene container of acidity of pH=1.5 are suitable for storing trace Ir in seawater. An anion exchange preconcentration-neutron activation analysis procedure is developed to determine iridium in seawaters sampled from the Bering Sea and Arctic Ocean at different depth. The reagent blank value of the whole procedures is (0.18-0.20) x 10 -12 g Ir. The iridium concentrations in the Bering Sea and Arctic Ocean seawater samples are (0.85-3.58) x 10 -12 g/L (0-3504 m) and (1.26-1.97) x 10 -12 g/L (25-1900 m), respectively

  5. Surface Rheology and Adsorption Kinetics Reveal the Relative Amphiphilicity, Interfacial Activity, and Stability of Human Exchangeable Apolipoproteins☆

    Science.gov (United States)

    Bolanos-Garcia, Victor Martin; Renault, Anne; Beaufils, Sylvie

    2008-01-01

    Exchangeable apolipoproteins are located in the surface of lipoprotein particles and regulate lipid metabolism through direct protein-protein and protein-lipid interactions. These proteins are characterized by the presence of tandem repeats of amphiphatic α-helix segments and a high surface activity in monolayers and lipoprotein surfaces. A noteworthy aspect in the description of the function of exchangeable apolipoproteins is the requirement of a quantitative account of the relation between their physicochemical and structural characteristics and changes in the mesoscopic system parameters such as the maximum surface pressure and relative stability at interfaces. To comply with this demand, we set out to establish the relations among α-helix amphiphilicity, surface concentration, and surface rheology of apolipoproteins ApoA-I, ApoA-II, ApoC-I, ApoC-II, and ApoC-III adsorbed at the air-water interface. Our studies render further insights into the interfacial properties of exchangeable apolipoproteins, including the kinetics of their adsorption and the physical properties of the interfacial layer. PMID:17993480

  6. Development of a transparent, non-cytotoxic, silver ion-exchanged glass with antimicrobial activity and low ion elution.

    Science.gov (United States)

    Shim, Gyu-In; Kim, Seong-Hwan; Eom, Hyung-Woo; Kim, Kwang-Mahn; Choi, Se-Young

    2015-05-01

    We investigated the antimicrobial, cytotoxicity, skin irritation, and ion elution behaviors of glass doped with silver ions with respect to its application to electronic equipment such as phones and tablet screens. The microbes tested were Escherichia coli, Staphylococcus aureus, and Penicillium funiculosum. AgNO3 powder was spread on both sides of aluminosilicate glass, and it was heated to 250-280°C for 10min. Under optimized heating conditions (260°C, 10min), the antimicrobial activity of ion-exchanged glass against bacteria and fungi was over 99.9% after 24 weeks. The glass failed to irritate the skin of experimental animals and was considered non-cytotoxic. The maximum amount of Ag ions that were eluted from the ion-exchanged glass into drinking water was measured at 0.037±0.003μgL(-1), an amount which is several orders of magnitude below the standard limit of 0.1mgL(-1) in drinking water. Ag ion-exchanged glass had characteristics suitable for use as a display screen, such as a light transmittance of 90% and a surface roughness of 0.704nm. Our findings suggest that glass doped with silver ions is more hygienic than non-doped glass is, and should be applied to display screens and glassware. Copyright © 2015 Elsevier Inc. All rights reserved.

  7. Product technology and market assessment for silicon carbide whisker reinforced alumina heat-exchanger tubes. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Loutfy, R.O.; Withers, J.C. [Materials and Electrochemical Research Corp., Tucson, AZ (United States); Chakravarti, D. [Arizona Univ., Tucson, AZ (United States)

    1993-10-01

    This report describes a study designed to develop an assessment of key performance features, desirable technical specifications and market potential for silicon carbide whisker-reinforced alumina (henceforth SCWRA) tubes for heat exchanger applications in a number of industries. The results of the first stage of a Delphi study conducted in the US market are presented. The second phase of the study is in progress. The first stage results suggest that there is a small market for SCWRA tubes in heat exchanger applications. The market is expected to grow steadily during the 1990`s. With appropriate performance specifications and competitive pricing, growth should come from (a) new applications that permit recovery in cases that were previously infeasible and (b) selective, partial substitution and replacement of current ceramics and metal/ceramic composites in existing applications. We identify key performance factors and detailed specifications needed in six designated industries (primary metals, fabricated metals, chemicals, glass, utility and incinerators). Reliability, durability and low maintenance costs emerge as critical performance factors across these industries. The data show that although ceramics are recognized as having better properties, enhancing reliability and durability and thus improving maintenance cost performance is a key priority. Such improvements, reflected in the objectives for SCWRA tubes, should facilitate adoption in both new and existing applications. At this time, we are unable to assess market size directly. However, expert judgment provided indices tracking the projected market for heat exchanger tubes from 1990 to 2005.

  8. Activity of tonoplast proton pumps and Na+/H+ exchange in potato cell cultures is modulated by salt.

    Science.gov (United States)

    Queirós, Filipa; Fontes, Natacha; Silva, Paulo; Almeida, Domingos; Maeshima, Masayoshi; Gerós, Hernâni; Fidalgo, Fernanda

    2009-01-01

    The efficient exclusion of excess Na from the cytoplasm and vacuolar Na(+) accumulation are the main mechanisms for the adaptation of plants to salt stress. This is typically carried out by transmembrane transport proteins that exclude Na(+) from the cytosol in exchange for H(+), a secondary transport process which is energy-dependent and driven by the proton-motive force generated by plasma-membrane and tonoplast proton pumps. Tonoplast enriched-vesicles from control and 150 mM NaCl-tolerant calli lines were used as a model system to study the activity of V-H(+)-PPase and V-H(+)-ATPase and the involvement of Na(+) compartmentalization into the vacuole as a mechanism of salt tolerance in Solanum tuberosum. Both ATP- and pyrophosphate (PP(i))-dependent H(+)-transport were higher in tonoplast vesicles from the salt-tolerant line than in vesicles from control cells. Western blotting of tonoplast proteins confirmed that changes in V-H(+)-PPase activity are correlated with increased protein amount. Conversely, immunodetection of the A-subunit of V-H(+)-ATPase revealed that a mechanism of post-translational regulation is probably involved. Na(+)-dependent dissipation of a pre-established pH gradient was used to measure Na(+)/H(+) exchange in tonoplast vesicles. The initial rates of proton efflux followed Michaelis-Menten kinetics and the V(max) of proton dissipation was 2-fold higher in NaCl-tolerant calli when compared to the control. H(+)-coupled exchange was specific for Na(+) and Li(+) and not for K(+). The increase of both the pH gradient across the tonoplast and the Na(+)/H(+) antiport activity in response to salt strongly suggests that Na(+) sequestration into the vacuole contributes to salt tolerance in potato.

  9. Na{sup +}/H{sup +} exchanger-1 alleles: Strain distribution and correlation with activity

    Energy Technology Data Exchange (ETDEWEB)

    McClive, P.J.; Morahan, G. [Walter and Eliza Hall Inst. of Medical Research, Parkville, Victoria (Australia); Little, P.J. [Baker Medical Research Inst., Victoria (Australia)

    1996-12-31

    The Na{sup +}/H{sup +} exchanger-1 molecule (NHE1) regulates intracellular pH, cell volume, and cell growth. NHE1 is a phosphoprotein of approximately M{sub r} 110000 with 10 or 12 transmembrane domains. NHE1 is ubiquitously expressed. Three other family members have been identified which show close similarity to NHE1 but are significantly more restricted in their expression: all are found in the gastrointestinal tract, while NHE2 and NHE3 are also expressed in the kidney. 14 refs., 2 figs.

  10. Performance of active vibration control technology: the ACTEX flight experiments

    Science.gov (United States)

    Nye, T. W.; Manning, R. A.; Qassim, K.

    1999-12-01

    This paper discusses the development and results of two intelligent structures space-flight experiments, each of which could affect architecture designs of future spacecraft. The first, the advanced controls technology experiment I (ACTEX I), is a variable stiffness tripod structure riding as a secondary payload on a classified spacecraft. It has been operating well past its expected life since becoming operational in 1996. Over 60 on-orbit experiments have been run on the ACTEX I flight experiment. These experiments form the basis for in-space controller design problems and for concluding lifetime/reliability data on the active control components. Transfer functions taken during the life of ACTEX I have shown consistent predictability and stability in structural behavior, including consistency with those measurements taken on the ground prior to a three year storage period and the launch event. ACTEX I can change its modal characteristics by employing its dynamic change mechanism that varies preloads in portions of its structure. Active control experiments have demonstrated maximum vibration reductions of 29 dB and 16 dB in the first two variable modes of the system, while operating over a remarkable on-orbit temperature range of -80 °C to 129 °C. The second experiment, ACTEX II, was successfully designed, ground-tested, and integrated on an experimental Department of Defense satellite prior to its loss during a launch vehicle failure in 1995. ACTEX II also had variable modal behavior by virtue of a two-axis gimbal and added challenges of structural flexibility by being a large deployable appendage. Although the loss of ACTEX II did not provide space environment experience, ground testing resulted in space qualifying the hardware and demonstrated 21 dB, 14 dB, and 8 dB reductions in amplitude of the first three primary structural modes. ACTEX II could use either active and/or passive techniques to affect vibration suppression. Both experiments trailblazed

  11. Air quality status in Kinshasa as determined by instrumental neutron activation analysis, atomic absorption spectrometry and ion-exchange chromatography

    International Nuclear Information System (INIS)

    Lobo, K.K.

    1991-01-01

    Three independent analytical techniques - instrumental neutron activation analysis. Atomic absorption spectrometry and ion-exchange chromatography - were applied to airborne particulate collected on filters and to atmospheric acid gases collected in carbonate buffer solutions. 20 trace elements and 7 acid gases and acid aerosols were determined. Results were compared with those observed elsewhere and showed that air pollution is low in Kinshasa and does not give rise to anxieties. The main known sources of pollutants are: vehicle exhaust and aeolian process on stripped soils. (author). 13 refs, 2 figs, 6 tabs

  12. Passive and Active Sensing Technologies for Structural Health Monitoring

    Science.gov (United States)

    Do, Richard

    A combination of passive and active sensing technologies is proposed as a structural health monitoring solution for several applications. Passive sensing is differentiated from active sensing in that with the former, no energy is intentionally imparted into the structure under test; sensors are deployed in a pure detection mode for collecting data mined for structural health monitoring purposes. In this thesis, passive sensing using embedded fiber Bragg grating optical strain gages was used to detect varying degrees of impact damage using two different classes of features drawn from traditional spectral analysis and auto-regressive time series modeling. The two feature classes were compared in detail through receiver operating curve performance analysis. The passive detection problem was then augmented with an active sensing system using ultrasonic guided waves (UGWs). This thesis considered two main challenges associated with UGW SHM including in-situ wave propagation property determination and thermal corruption of data. Regarding determination of wave propagation properties, of which dispersion characteristics are the most important, a new dispersion curve extraction method called sparse wavenumber analysis (SWA) was experimentally validated. Also, because UGWs are extremely sensitive to ambient temperature changes on the structure, it significantly affects the wave propagation properties by causing large errors in the residual error in the processing of the UGWs from an array. This thesis presented a novel method that compensates for uniform temperature change by considering the magnitude and phase of the signal separately and applying a scalable transformation.

  13. Monolithic active pixel sensors (MAPS) in a VLSI CMOS technology

    CERN Document Server

    Turchetta, R; Manolopoulos, S; Tyndel, M; Allport, P P; Bates, R; O'Shea, V; Hall, G; Raymond, M

    2003-01-01

    Monolithic Active Pixel Sensors (MAPS) designed in a standard VLSI CMOS technology have recently been proposed as a compact pixel detector for the detection of high-energy charged particle in vertex/tracking applications. MAPS, also named CMOS sensors, are already extensively used in visible light applications. With respect to other competing imaging technologies, CMOS sensors have several potential advantages in terms of low cost, low power, lower noise at higher speed, random access of pixels which allows windowing of region of interest, ability to integrate several functions on the same chip. This brings altogether to the concept of 'camera-on-a-chip'. In this paper, we review the use of CMOS sensors for particle physics and we analyse their performances in term of the efficiency (fill factor), signal generation, noise, readout speed and sensor area. In most of high-energy physics applications, data reduction is needed in the sensor at an early stage of the data processing before transfer of the data to ta...

  14. Improvement of Electrochemical Activity of Pt/MWCNT Catalyst for Proton Exchange Membrane Fuel Cell

    Directory of Open Access Journals (Sweden)

    Munkhshur Myekhlai

    2014-09-01

    Full Text Available In last years, the carbon nanotubes have been studied as an advanced metal catalyst support for proton exchange membrane fuel cell. This study focuses on the sonochemical treatment of multi walled carbon nanotubes (MWCNTs as a platinum supporting material for proton exchange membrane fuel cell (PEMFC by mixture of sulfuric acid and nitric acid and mixture of sulfuric acid and hydrogen peroxide. X-ray diffraction (XRD and Infrared (IR spectroscopy were used to characterize the surface of sonochemically treated MWCNT and nanostructured electrocatalyst Pt/MWCNT. According to the experimental results of this work, the surface of MWCNT can be more successfully functionalized with hydroxyl and carboxyl groups after sonochemical treatment by mixture of sulfuric acid and nitric acid. The particle size of prepared Pt -electrocatalyst on MWCNT was determined 3.4 nm by XRD.DOI: http://dx.doi.org/10.5564/mjc.v12i0.165 Mongolian Journal of Chemistry Vol.12 2011: 20-23

  15. H2/D2 exchange reaction on mono-disperse Pt clusters: enhanced activity from minute O2 concentrations

    DEFF Research Database (Denmark)

    Riedel, Jakob Nordheim; Rötzer, Marian David; Jørgensen, Mikkel

    2016-01-01

    significantly. XPS and ISS before and after reaction suggest little or no sintering during reaction. A reaction pathway is suggested based on DFT. H2 desorption is identified as the rate-limiting step and O2 is confirmed as the source of the increased activity. The binding energy of platinum atoms in a SiO2......The H2/D2 exchange reaction was studied on mono-disperse Pt8 clusters in a μ-reactor. The chemical activity was studied at temperatures varying from room temperature to 180 °C using mass spectrometry. It was found that minute amounts of O2 in the gas stream increased the chemical activity...

  16. Comparison of Exams for Active Learning Technologies vs. Traditional Lectures

    Science.gov (United States)

    Hornstra, Andrew; Djordjevic, Branislav; Dworzecka, Maria

    2017-01-01

    George Mason University has first semester (PHYS-160) and second semester (PHYS-260) physics course which consist of two sections. One is a traditional lecture style format (TRAD) and the other is a newer format which is a take on the ``flipped'' classroom. This newer style is referred to as Active Learning with Technologies (ALT). This course style has been in place for several years and has been studied before within George Mason University for final grade differences. These studies suggested that the ALT sections performed better, but grade weighting consistency, test time, and test content were not strictly controlled. The purpose of this study is to cross-examine the performance of students in these different class formats during Fall 2016 (PHYS-260) and Spring 2015 (PHYS-160) on very nearly identical exams over identical test times while controlling for almost every variable.

  17. Strengthening technological capabilities: A challenge for the nineties. A review of ILO activities on technology. 3. ed.

    International Nuclear Information System (INIS)

    1992-01-01

    This report was inspired by the 11th Session (1991) of the Intergovernmental Committee on Science and Technology for Development (IGC) where ILO activities figured prominently in the documentation and discussions that took place on the trends in the programmes and activities of the UN system in science and technology for development. The report deals with ILO activities in the areas of endogenous capacity building, technology policy assessment, anticipation of employment effects of new technologies, assessment of the effects of new technologies on working conditions and working environment, training needs for the effective utilisation of new technologies, technological change and industrial relations and the dissemination of technological information. It also reports on the new ILO work launched on environment and employment, including the role of environmentally sound technologies. The concluding chapter of the report deals with interagency collaboration to which the ILO has always attached importance. ILO work evolving policies for occupational safety and health is described in the following distinct areas of new technologies: (i) man-made mineral fibres; (ii) biotechnology, (iii) robotisation; (iv) chemicals; and (v) dismantling of nuclear power plants

  18. Veterans' Preferences for Exchanging Information Using Veterans Affairs Health Information Technologies: Focus Group Results and Modeling Simulations.

    Science.gov (United States)

    Haun, Jolie N; Chavez, Margeaux; Nazi, Kim; Antinori, Nicole; Melillo, Christine; Cotner, Bridget A; Hathaway, Wendy; Cook, Ashley; Wilck, Nancy; Noonan, Abigail

    2017-10-23

    The Department of Veterans Affairs (VA) has multiple health information technology (HIT) resources for veterans to support their health care management. These include a patient portal, VetLink Kiosks, mobile apps, and telehealth services. The veteran patient population has a variety of needs and preferences that can inform current VA HIT redesign efforts to meet consumer needs. This study aimed to describe veterans' experiences using the current VA HIT and identify their vision for the future of an integrated VA HIT system. Two rounds of focus group interviews were conducted with a single cohort of 47 veterans and one female caregiver recruited from Bedford, Massachusetts, and Tampa, Florida. Focus group interviews included simulation modeling activities and a self-administered survey. This study also used an expert panel group to provide data and input throughout the study process. High-fidelity, interactive simulations were created and used to facilitate collection of qualitative data. The simulations were developed based on system requirements, data collected through operational efforts, and participants' reported preferences for using VA HIT. Pairwise comparison activities of HIT resources were conducted with both focus groups and the expert panel. Rapid iterative content analysis was used to analyze qualitative data. Descriptive statistics summarized quantitative data. Data themes included (1) current use of VA HIT, (2) non-VA HIT use, and (3) preferences for future use of VA HIT. Data indicated that, although the Secure Messaging feature was often preferred, a full range of HIT options are needed. These data were then used to develop veteran-driven simulations that illustrate user needs and expectations when using a HIT system and services to access VA health care services. Patient participant redesign processes present critical opportunities for creating a human-centered design. Veterans value virtual health care options and prefer standardized, integrated

  19. Ligand Exchange-Mediated Activation and Stabilization of a Re-Based Olefin Metathesis Catalyst by Chlorinated Alumina.

    Science.gov (United States)

    Gallo, Alessandro; Fong, Anthony; Szeto, Kai C; Rieb, Julia; Delevoye, Laurent; Gauvin, Régis M; Taoufik, Mostafa; Peters, Baron; Scott, Susannah L

    2016-10-05

    Extensive chlorination of γ-Al 2 O 3 results in the formation of highly Lewis acidic surface domains depleted in surface hydroxyl groups. Adsorption of methyltrioxorhenium (MTO) onto these chlorinated domains serves to activate it as a low temperature, heterogeneous olefin metathesis catalyst and confers both high activity and high stability. Characterization of the catalyst reveals that the immobilized MTO undergoes partial ligand exchange with the surface, whereby some Re sites acquire a chloride ligand from the modified alumina while donating an oxo ligand to the support. More specifically, Re L III -edge EXAFS and DFT calculations support facile ligand exchange between MTO and Cl-Al 2 O 3 to generate [CH 3 ReO 2 Cl + ] fragments that interact with a bridging oxygen of the support via a Lewis acid-base interaction. According to IR and solid-state NMR, the methyl group remains intact, and does not evolve spontaneously to a stable methylene tautomer. Nevertheless, the chloride-promoted metathesis catalyst is far more active and productive than MTO/γ-Al 2 O 3 , easily achieving a TON of 100 000 for propene metathesis in a flow reactor at 10 °C (compared to TON < 5000 for the nonchlorinated catalyst). Increased activity is a consequence of both a larger fraction of active sites and a higher intrinsic activity for the new sites. Increased stability is tentatively attributed to a stronger interaction between MTO and chlorinated surface regions, as well as extensive depletion of the Brønsted acidic surface hydroxyl population. The reformulated catalyst represents a major advance for Re-based metathesis catalysts, whose widespread use has thus far been severely hampered by their instability.

  20. Exchange transfusion

    Science.gov (United States)

    ... count in a newborn (neonatal polycythemia) Rh-induced hemolytic disease of the newborn Severe disturbances in body chemistry Severe newborn jaundice ... exchange transfusion was performed to treat. Alternative Names Hemolytic disease - exchange transfusion Patient ... Exchange transfusion - series References Costa ...

  1. Life cycle assessment of active and passive groundwater remediation technologies

    Science.gov (United States)

    Bayer, Peter; Finkel, Michael

    2006-02-01

    the valuation of FGS due to the associated emissions that are harmful to human health. In view of that, environmental credits can be achieved by selecting a mineral-based wall instead of sheet piles for the funnel construction and by minimising the steel consumption for the gate construction. Granular activated carbon (GAC) is exclusively considered as the treatment material, both in-situ and on-site. Here it is identified as an additional main determinant of the relative assessment of the technologies since it is continuously consumed.

  2. Development of Technology and Equipment of the Automated Laser Welding for Manufacturing Heat Exchanger Details of Marine Engines

    Directory of Open Access Journals (Sweden)

    Shelyagin, V.D.

    2014-09-01

    Full Text Available Based on the developed automated laser welding technology for flat tubes of copper-nickel alloys laser welding complex technological equipment, which can be applied on the enterprises of machine building, aerospace, shipbuilding and automobile industries, was designed and created. To control the integrity of welded flat tubes a technique, which consists in testing sample pressure and finding defective sections by laser interferometry in the automated mode, was developed. Specialized welding head was designed and manufactured for the industrial use of the developed laser welding technology.

  3. Rapid Prototyping Technologies for Manufacturing and Maintenance Activities

    Science.gov (United States)

    Pfeifer, Marcel Rolf

    2017-12-01

    The paper deals with the direct application of Rapid Prototyping technologies for parts and spare parts production in production companies and the economic effect by making use of this technology. Traditional production technologies are technologies such as forging, cutting, machining, etc. These technologies are widely accepted and the teething troubles are solved. Rapid Prototyping technologies such as 3D printing on the other hand came into the focus in the recent years when the technologies and the produced quality gradually advanced. Providing flexibility and time efficiency the technology should also have a practical application in production. This paper has the aim to provide a case-study based on existing cost figures to show that these technologies are not limited to prototype developments.

  4. Conformational dynamics of free and catalytically active thermolysin are indistinguishable by hydrogen/deuterium exchange mass spectrometry.

    Science.gov (United States)

    Liu, Yu-Hong; Konermann, Lars

    2008-06-17

    Conformational dynamics are thought to be a prerequisite for the catalytic activity of enzymes. However, the exact relationship between structural fluctuations and function is not well understood. In this work hydrogen/deuterium exchange (HDX) and electrospray ionization mass spectrometry (ESI-MS) are used for exploring the conformational dynamics of thermolysin. Amide HDX reflects the internal mobility of proteins; regions that undergo frequent unfolding-refolding show faster exchange than segments that are highly stable. Thermolysin is a zinc protease with an active site that is located between two lobes. Substrate turnover is associated with hinge bending that leads to a closed conformation. Product release regenerates the open form, such that steady-state catalysis involves a continuous closing/opening cycle. HDX/ESI-MS with proteolytic peptide mapping in the absence of substrate shows that elements in the periphery of the two lobes are most mobile. A comparison with previous X-ray data suggests that these peripheral regions undergo quite pronounced structural changes during the catalytic cycle. In contrast, active site residues exhibit only a moderate degree of backbone flexibility, and the central zinc appears to be in a fairly rigid environment. The presence of both rigid and moderately flexible elements in the active site may reflect a carefully tuned balance that is required for function. Interestingly, the HDX behavior of catalytically active thermolysin is indistinguishable from that of the free enzyme. This result is consistent with the view that catalytically relevant motions preexist in the resting state and that enzyme function can only be performed within the limitations given by the intrinsic dynamics of the protein. The data presented in this work indicate the prevalence of stochastic elements in the function of thermolysin, rather than supporting a deterministic mechanism.

  5. Sustained Na+/H+ exchanger activation promotes gliotransmitter release from reactive hippocampal astrocytes following oxygen-glucose deprivation.

    Directory of Open Access Journals (Sweden)

    Pelin Cengiz

    Full Text Available Hypoxia ischemia (HI-related brain injury is the major cause of long-term morbidity in neonates. One characteristic hallmark of neonatal HI is the development of reactive astrogliosis in the hippocampus. However, the impact of reactive astrogliosis in hippocampal damage after neonatal HI is not fully understood. In the current study, we investigated the role of Na(+/H(+ exchanger isoform 1 (NHE1 protein in mouse reactive hippocampal astrocyte function in an in vitro ischemia model (oxygen/glucose deprivation and reoxygenation, OGD/REOX. 2 h OGD significantly increased NHE1 protein expression and NHE1-mediated H(+ efflux in hippocampal astrocytes. NHE1 activity remained stimulated during 1-5 h REOX and returned to the basal level at 24 h REOX. NHE1 activation in hippocampal astrocytes resulted in intracellular Na(+ and Ca(2+ overload. The latter was mediated by reversal of Na(+/Ca(2+ exchange. Hippocampal astrocytes also exhibited a robust release of gliotransmitters (glutamate and pro-inflammatory cytokines IL-6 and TNFα during 1-24 h REOX. Interestingly, inhibition of NHE1 activity with its potent inhibitor HOE 642 not only reduced Na(+ overload but also gliotransmitter release from hippocampal astrocytes. The noncompetitive excitatory amino acid transporter inhibitor TBOA showed a similar effect on blocking the glutamate release. Taken together, we concluded that NHE1 plays an essential role in maintaining H(+ homeostasis in hippocampal astrocytes. Over-stimulation of NHE1 activity following in vitro ischemia disrupts Na(+ and Ca(2+ homeostasis, which reduces Na(+-dependent glutamate uptake and promotes release of glutamate and cytokines from reactive astrocytes. Therefore, blocking sustained NHE1 activation in reactive astrocytes may provide neuroprotection following HI.

  6. Sustained Na+/H+ exchanger activation promotes gliotransmitter release from reactive hippocampal astrocytes following oxygen-glucose deprivation.

    Science.gov (United States)

    Cengiz, Pelin; Kintner, Douglas B; Chanana, Vishal; Yuan, Hui; Akture, Erinc; Kendigelen, Pinar; Begum, Gulnaz; Fidan, Emin; Uluc, Kutluay; Ferrazzano, Peter; Sun, Dandan

    2014-01-01

    Hypoxia ischemia (HI)-related brain injury is the major cause of long-term morbidity in neonates. One characteristic hallmark of neonatal HI is the development of reactive astrogliosis in the hippocampus. However, the impact of reactive astrogliosis in hippocampal damage after neonatal HI is not fully understood. In the current study, we investigated the role of Na(+)/H(+) exchanger isoform 1 (NHE1) protein in mouse reactive hippocampal astrocyte function in an in vitro ischemia model (oxygen/glucose deprivation and reoxygenation, OGD/REOX). 2 h OGD significantly increased NHE1 protein expression and NHE1-mediated H(+) efflux in hippocampal astrocytes. NHE1 activity remained stimulated during 1-5 h REOX and returned to the basal level at 24 h REOX. NHE1 activation in hippocampal astrocytes resulted in intracellular Na(+) and Ca(2+) overload. The latter was mediated by reversal of Na(+)/Ca(2+) exchange. Hippocampal astrocytes also exhibited a robust release of gliotransmitters (glutamate and pro-inflammatory cytokines IL-6 and TNFα) during 1-24 h REOX. Interestingly, inhibition of NHE1 activity with its potent inhibitor HOE 642 not only reduced Na(+) overload but also gliotransmitter release from hippocampal astrocytes. The noncompetitive excitatory amino acid transporter inhibitor TBOA showed a similar effect on blocking the glutamate release. Taken together, we concluded that NHE1 plays an essential role in maintaining H(+) homeostasis in hippocampal astrocytes. Over-stimulation of NHE1 activity following in vitro ischemia disrupts Na(+) and Ca(2+) homeostasis, which reduces Na(+)-dependent glutamate uptake and promotes release of glutamate and cytokines from reactive astrocytes. Therefore, blocking sustained NHE1 activation in reactive astrocytes may provide neuroprotection following HI.

  7. NASA/University JOint VEnture (JOVE) Program. VIXEN(tm): Object-Oriented, Technology-Adaptive, Virtual Information Exchange Environment

    Science.gov (United States)

    Anyiwo, Joshua C.

    2000-01-01

    Vixen is a collection of enabling technologies for uninhibited distributed object computing. In the Spring of 1995 when Vixen was proposed, it was an innovative idea very much ahead of its time. But today the technologies proposed in Vixen have become standard technologies for Enterprise Computing. Sun Microsystems J2EE/EJB specifications, among others, are independently proposed technologies of the Vixen type. I have brought Vixen completely under the J2EE standard in order to maximize interoperability and compatibility with other computing industry efforts. Vixen and the Enterprise JavaBean (EJB) Server technologies are now practically identical; OIL, another Vixen technology, and the Java Messaging System (JMS) are practically identical; and so on. There is no longer anything novel or patentable in the Vixen work performed under this grant. The above discussion, notwithstanding, my independent development of Vixen has significantly helped me, my university, my students and the local community. The undergraduate students who worked with me in developing Vixen have enhanced their expertise in what has become the cutting edge technology of their industry and are therefore well positioned for lucrative employment opportunities in the industry. My academic department has gained a new course: "Multi-media System Development", which provides a highly desirable expertise to our students for employment in any enterprise today. The many Outreach Programs that I conducted during this grant period have exposed local Middle School students to the contributions that NASA is making in our society as well as awakened desires in many such students for careers in Science and Technology. I have applied Vixen to the development of two software packages: (a) JAS: Joshua Application Server - which allows a user to configure an EJB Server to serve a J2EE compliant application over the world wide web; (b) PCM: Professor Course Manager: a J2EE compliant application for configuring a

  8. Information Technology and Aesthetics: Passive and Active Dimensions

    Directory of Open Access Journals (Sweden)

    John D Haynes

    2007-09-01

    Full Text Available This paper is concerned with examining and recognizing aesthetics in an Information System (an organization incorporating both humans and information technology. Aesthetics emerge from the wholeness of things, not from specific parts or components. As such, aesthetics may naturally be considered in “systems”, and we propose that an effective manner of thinking of aesthetics is to think in terms of “themes”. Humans have an extraordinary capacity to capture events thematically. In other words, human beings have a natural sense of aesthetics. To examine aesthetics in an information systems context, we argue that one must consider not only aesthetics that may be perceived by the senses (a passive dimension, but also aesthetics that may be conceived in the mind (an active dimension. This paper draws the conclusion that the benefits of aesthetics in relation to the study of Information Systems, has characteristics similar to the nature and importance of ethics in IS. Also, the study of aesthetics in IS has greater implications than simply recognizing and appreciating beauty and art. The very human capacity for recognizing and appreciating beauty and art is also the same capacity for effective creativity and happiness: the active aesthetic dimension. It follows that if an information system encouraged and provided the enabling circumstances for the human capacity of thematic recognition (as found in the human appreciation of art and beauty it thereby also provides the ground and the necessary thematically recognizable stimulus for effective creative and visionary organizational management.

  9. How Technology and Collaboration Promote Formative Feedback: A Role for CSCL Research in Active Learning Interventions

    Science.gov (United States)

    Wu, Sally P. W.; Rau, Martina A.

    2017-01-01

    Recent evidence for the effectiveness of active learning interventions has led educators to advocate for widespread adoption of active learning in undergraduate science, technology, engineering, and mathematics courses. Active learning interventions implement technology and collaboration to engage students actively with the content. Yet, it is…

  10. Activity-regulating structural changes and autoantibody epitopes in transglutaminase 2 assessed by hydrogen/deuterium exchange

    DEFF Research Database (Denmark)

    Iversen, Rasmus; Mysling, Simon; Hnida, Kathrin

    2014-01-01

    The multifunctional enzyme transglutaminase 2 (TG2) is the target of autoantibodies in the gluten-sensitive enteropathy celiac disease. In addition, the enzyme is responsible for deamidation of gluten peptides, which are subsequently targeted by T cells. To understand the regulation of TG2 activity...... and the enzyme's role as an autoantigen in celiac disease, we have addressed structural properties of TG2 in solution by using hydrogen/deuterium exchange monitored by mass spectrometry. We demonstrate that Ca(2+) binding, which is necessary for TG2 activity, induces structural changes in the catalytic core...... domain of the enzyme. Cysteine oxidation was found to abolish these changes, suggesting a mechanism whereby disulfide bond formation inactivates the enzyme. Further, by using TG2-specific human monoclonal antibodies generated from intestinal plasma cells of celiac disease patients, we observed...

  11. Teachers as co-designers of technology-rich learning activities for emergent literacy

    NARCIS (Netherlands)

    Cviko, Amina; McKenney, Susan; Voogt, Joke

    2016-01-01

    Although kindergarten teachers often struggle with implementing technology, they are rarely involved in co-designing technology-rich learning activities. This study involved teachers in the co-design of technology-rich learning activities and sought to explore implementation and pupil learning

  12. Teachers as co-designers of technology-rich learning activities for early literacy

    NARCIS (Netherlands)

    Cviko, Amina; McKenney, Susan; Voogt, Joke

    2015-01-01

    Although kindergarten teachers often struggle with implementing technology, they are rarely involved in co-designing technology-rich learning activities. This study involved teachers in the co-design of technology-rich learning activities and sought to explore implementation and pupil learning

  13. Catalytic activity of Ni-Cr2O3 in the H2-NH3 and H2-H2O deuterium exchange reactions

    International Nuclear Information System (INIS)

    Palibroda, N.; Grecu, E.; Marginean, P.

    1986-01-01

    The activity of Ni-Cr 2 O 3 catalyst for the deuterium exchange reactions between hydrogen and ammonia, as well as for hydrogen and water vapor has been measured as a function of the reaction temperature and the partial pressure of ammonia and water vapor, respectively. In both cases the activity shows a maximum depending on the partial pressure; the maximum of activity for H 2 -NH 3 exchange is situated between partial pressures of 0.05 and 0.25, and for H 2 -H 2 O reaction between 0.25 and 0.5. The Ni-Cr 2 O 3 catalyst is about 2.4 more active for the exchange reaction H 2 -H 2 O than for H 2 -NH 3 . For both reactions, chromium(III) oxide has a strong promoting effect, enhancing the activity per gram of catalyst of about three orders of magnitude in comparison with that of nickel. (author)

  14. Active neutral particle diagnostics on LHD by locally enhanced charge exchange on an impurity pellet ablation cloud

    International Nuclear Information System (INIS)

    Goncharov, P.R.; Ozaki, T.; Sudo, S.; Tamura, N.; Kalinina, D.V.; Veshchev, E.A.

    2005-01-01

    Production, confinement and thermalization of high-energy particles are the fundamental issues in fusion plasma ion kinetics. The ion distribution function and its evolution under the ion cyclotron heating and neutral beam injection are studied by energy resolved charge exchange neutral flux measurements. For helical systems, such as LHD, local diagnostics are required due to the complex 3D magnetic field. In passive methods one needs to analyze the integral relation between the plasma ion distribution function and the observed neutral flux, which is a superposition along the diagnostic sightline, taking into account the charge exchange target density profile. In active measurements either a diagnostic neutral beam or a solid pellet injection are used to enhance the charge exchange locally. An impurity pellet ablation cloud r cloud plasma provides a localized charge exchange target scanning the plasma radially. Pellet-induced neutral fluxes were previously measured on LHD with a natural diamond detector. However, obtaining the energy spectra from these data in the main energy range of interest (10 1 -10 2 keV in the present experiments) is complicated due to the high operating speed, i.e. the spatial resolution requirement. A new diagnostic based on a compact neutral particle analyser (CNPA) has been installed on LHD for measurements in the H 0 energy range 1 - 170 keV. CNPA employs a thin 50 A diamond-like carbon stripping film instead of a traditional gas stripping cell, a high-field-strength permanent analysing magnet and an array of 40 channel electron multipliers (CEMs) for particle detection. CEMs can be used in both counting and current modes to be able to process high neutral particle fluxes from the charge exchange on the dense pellet cloud. Thus, the system is suitable for both passive measurements and the active probing with a diagnostic pellet. Pneumatically accelerated polystyrene (-C 8 H 8 -) n balls are injected transversally; typical D pel = 500

  15. Science and technology as strategic way for nuclear activities

    International Nuclear Information System (INIS)

    Paiano, Silvestre

    2000-01-01

    The article brings few instructive examples on the interaction between nuclear energy and other areas of science and technology, Microelectronics, computer technology, and new materials are among the many technologies which are crucial for developing nuclear energy technology. On the other way round, nuclear energy presents also a wide range of new demands and opportunities for several areas of science and technology. The problem is that such a relationship is not well understood by the society, and to a large extent it brings about the very process of legitimating the use of nuclear energy (author)

  16. Teachers' Technological Pedagogical Content Knowledge and Learning Activity Types: Curriculum-Based Technology Integration Reframed

    Science.gov (United States)

    Harris, Judith; Mishra, Punya; Koehler, Matthew

    2009-01-01

    In this paper we critically analyze extant approaches to technology integration in teaching, arguing that many current methods are technocentric, often omitting sufficient consideration of the dynamic and complex relationships among content, technology, pedagogy, and context. We recommend using the technology, pedagogy, and content knowledge…

  17. Barter exchanges

    DEFF Research Database (Denmark)

    Sudzina, Frantisek

    Although barter is often perceived as something that proceeded money, barter is still used. The focus of the paper is on barter exchanges. Barter exchanges are used both in developing countries as well as in developed countries (including the U.S.). They are used by both organizations...... and individuals. They usually allow to exchange good but some include also services. Some exchanges allow only for bi-directional barter, i.e. when only two parties are involved in the exchange. But probably most of the barter exchanges use barter money; this makes it easier to exchange goods and services...

  18. United States-Chile binational exchange for volcanic risk reduction, 2015—Activities and benefits

    Science.gov (United States)

    Pierson, Thomas C.; Mangan, Margaret T.; Lara Pulgar, Luis E.; Ramos Amigo, Álvaro

    2017-07-25

    In 2015, representatives from the United States and Chile exchanged visits to discuss and share their expertise and experiences dealing with volcano hazards. Communities in both countries are at risk from various volcano hazards. Risks to lives and property posed by these hazards are a function not only of the type and size of future eruptions but also of distances from volcanoes, structural integrity of volcanic edifices, landscape changes imposed by recent past eruptions, exposure of people and resources to harm, and any mitigative measures taken (or not taken) to reduce risk. Thus, effective risk-reduction efforts require the knowledge and consideration of many factors, and firsthand experience with past volcano crises provides a tremendous advantage for this work. However, most scientists monitoring volcanoes and most officials delegated with the responsibility for emergency response and management in volcanic areas have little or no firsthand experience with eruptions or volcano hazards. The reality is that eruptions are infrequent in most regions, and individual volcanoes may have dormant periods lasting hundreds to thousands of years. Knowledge may be lacking about how to best plan for and manage future volcanic crises, and much can be learned from the sharing of insights and experiences among counterpart specialists who have had direct, recent, or different experiences in dealing with restless volcanoes and threatened populations. The sharing of information and best practices can help all volcano scientists and officials to better prepare for future eruptions or noneruptive volcano hazards, such as large volcanic mudflows (lahars), which could affect their communities.

  19. Engineering and Technology Challenges for Active Debris Removal

    Science.gov (United States)

    Liou, Jer-Chyi

    2011-01-01

    After more than fifty years of space activities, the near-Earth environment is polluted with man-made orbital debris. The collision between Cosmos 2251 and the operational Iridium 33 in 2009 signaled a potential collision cascade effect, also known as the "Kessler Syndrome", in the environment. Various modelling studies have suggested that the commonly-adopted mitigation measures will not be sufficient to stabilize the future debris population. Active debris removal must be considered to remediate the environment. This paper summarizes the key issues associated with debris removal and describes the technology and engineering challenges to move forward. Fifty-four years after the launch of Sputnik 1, satellites have become an integral part of human society. Unfortunately, the ongoing space activities have left behind an undesirable byproduct orbital debris. This environment problem is threatening the current and future space activities. On average, two Shuttle window panels are replaced after every mission due to damage by micrometeoroid or orbital debris impacts. More than 100 collision avoidance maneuvers were conducted by satellite operators in 2010 to reduce the impact risks of their satellites with respect to objects in the U.S. Space Surveillance Network (SSN) catalog. Of the four known accident collisions between objects in the SSN catalog, the last one, collision between Cosmos 2251 and the operational Iridium 33 in 2009, was the most significant. It was the first ever accidental catastrophic destruction of an operational satellite by another satellite. It also signaled the potential collision cascade effect in the environment, commonly known as the "Kessler Syndrome," predicted by Kessler and Cour-Palais in 1978 [1]. Figure 1 shows the historical increase of objects in the SSN catalog. The majority of the catalog objects are 10 cm and larger. As of April 2011, the total objects tracked by the SSN sensors were more than 22,000. However, approximately 6000 of

  20. Experimental investigation of an active magnetic regenerative heat circulator applied to self-heat recuperation technology

    International Nuclear Information System (INIS)

    Kotani, Yui; Kansha, Yasuki; Ishizuka, Masanori; Tsutsumi, Atsushi

    2014-01-01

    An experimental investigation into an active magnetic regenerative (AMR) heat circulator based on self-heat recuperation technology, was conducted to evaluate its energy saving potential in heat circulation. In an AMR heat circulator, magnetocaloric effect is applied to recuperate the heat exergy of the process fluid. The recuperated heat can be reused to heat the feed process fluid and realize self-heat recuperation. In this paper, AMR heat circulator has newly been constructed to determine the amount of heat circulated when applied to self-heat recuperation and the energy consumption of the heat circulator. Gadolinium and water was used as the magnetocaloric working material and the process fluid, respectively. The heat circulated amount was determined by measuring the temperature of the process fluid and gadolinium. The net work input for heat circulation was obtained from the magnetizing and demagnetizing forces and the distance travelled by the magnetocaloric bed. The results were compared with the minimum work input needed for heat circulation derived from exergy loss during heat exchange. It was seen that the experimentally obtained value was close to the minimum work input needed for heat circulation. - Highlights: • AMR heat circulator has newly been constructed for experimental evaluation. • Heat circulation in the vicinity of Curie temperature was observed. • Energy consumption of an AMR heat circulator has been measured. • Energy saving for processes near Curie temperature of working material was seen

  1. Characteristics of Atmosphere-Ocean CO2 Exchange due to Typhoon Activities over the East Asian Region

    Science.gov (United States)

    Lee, G.; Cho, C. H.; Lim, D. H.; Sun, M.; Lee, J.; Byun, Y. H.; Lee, J.

    2014-12-01

    Although the oceans are generally known as a net carbon sink in global sense, it is expected that CO₂release from oceans can occur locally depending on specific weather. This study addresses investigation of change in CO2 exchange between atmosphere and ocean due to typhoon activities, using "Carbon Tracker-Asia (CTA)". The CTA has constructed and managed at National Institute of Meteorological Research(NIMR) based on Carbon Tracker developed by NOAA. In order to examine effect of typhoon on change in air-sea CO2 exchange, we selected several cases which typhoon approached to Korean peninsula in the summertime and their tracks are similar to each other. Also, we analyzed difference between CO2 flux along typhoon tracks and other adjacent region not to be directly affected by typhoon in these cases. There is a difference in ocean fluxes around 15 gC/m²yr over strong typhoon areas compared to other areas. This difference varied with the wind speeds, the correlation coefficient between the ocean and the wind flux was found 0.7. Changes in carbon flux to affect the concentration of CO₂ in the atmosphere near surface instantly.

  2. How to change GEBCO outreach activities with Information technologies?

    Science.gov (United States)

    Chang, E.; Park, K.

    2014-12-01

    Since 1995, when National Geographic Information Project began, we have great advance in mapping itself and information service on the earth surface in Korea whether paper maps or online service map. By reviewing geological and mine-related information service in current and comparisons of demands, GEBCO outreach master plan has been prepared. Information service cannot be separated from data production and on dissemination policies. We suggest the potential impact of the changes in information technologies such as mobile service and data fusion, and big data on GEBCO maps based. Less cost and high performance in data service will stimulate more information service; therefore it is necessary to have more customer-oriented manipulation on the data. By inquiring questionnaire, we can draw the potential needs on GEBCO products in various aspects: such as education, accessibility. The gap between experts and non-experts will decrease by digital service from the private and public organizations such as international academic societies since research funds and policies tend to pursue "openness" and "interoperability" among the domains. Some background why and how to prepare outreach activities in GEBCO will be shown.

  3. Study on a program for support of women nuclear experts exchange and mutual utilization between WANO Korea and WANO Global

    International Nuclear Information System (INIS)

    Lee, Haecho; No, Inyoung; Min, Byungju

    2010-12-01

    - Nuclear energy, unlike other international human and material essential to mutual understanding, exchange of information and technology-intensive industries as required by an active technical cooperation and information exchange between countries is very important - WiN-Global Women's Domestic Nuclear specialists and professionals between countries belonging to the network for women through nuclear technology and nuclear power expansion opportunities to exchange information to secure a variety of communication

  4. Is the RFID technology ready to integrate supplychain activities?

    OpenAIRE

    Chan, Hing Kai; Chan, Felix T.S.

    2008-01-01

    Radio Frequency Identification (RFID) is not a new technology andhas been introduced for military applications for a long time. Nevertheless, ithas been recognised as a device that may soon change the mode of operationsthroughout the supply chain. There is no question that the technology willreduce labour and improve accuracy in inventory management by improvinginventory visibility. However, a review of recent research and the developmentof RFID technology in supply chain related applications...

  5. [Effects of nitrogen application rate on nitrate reductase activity, nitric oxide content and gas exchange in winter wheat leaves].

    Science.gov (United States)

    Shangguan, Zhou-Ping

    2007-07-01

    In this paper, the effects of different nitrogen application rates on the nitrate reductase (NR) activity, nitric oxide (NO) content and gas exchange parameters in winter wheat (Triticum aestivum L.) leaves from tillering stage to heading stage and on grain yield were studied. The results showed that the photosynthetic rate (P(n)), transpiration rate (T(r)) and instantaneous water use efficiency (IWUE) of leaves as well as the grain yield were increased with increasing nitrogen application rate first but decreased then, with the values of all these parameters reached the highest in treatment N180. The NR activity increased with increasing nitrogen application rate, and there was a significant linear correlation between NR activity and NO content at tillering and jointing stages (R2 > or = 0.68, n = 15). NO content had a quadratic positive correlation with stomatal conductance (G(s)) (R2 > or = 0.43, n = 15). The lower NO content produced by lower NR activity under lower nitrogen application rate promoted the stoma opened, while the higher NO content produced by higher NR activity under higher nitrogen application rate induced the stoma closed. Although the leaf NO content had a quadratic positive correlation with stomatal conductance (R2 > or = 0.36, n = 15), no remarkable correlation was observed between NR activity and NO content at heading stage, suggesting that nitrogen fertilization could not affect leaf NO content through promoting NR activity, and further more, regulate the stomatal action. Under appropriate nitrogen application the leaf NR activity and NO content were lower, G(s), T(r) and IWUE were higher, and thus, the crop had a better drought-resistant ability, higher P(n), and higher grain yield.

  6. Advanced Power Technology Development Activities for Small Satellite Applications

    Science.gov (United States)

    Piszczor, Michael F.; Landis, Geoffrey A.; Miller, Thomas B.; Taylor, Linda M.; Hernandez-Lugo, Dionne; Raffaelle, Ryne; Landi, Brian; Hubbard, Seth; Schauerman, Christopher; Ganter, Mathew; hide

    2017-01-01

    NASA Glenn Research Center (GRC) has a long history related to the development of advanced power technology for space applications. This expertise covers the breadth of energy generation (photovoltaics, thermal energy conversion, etc.), energy storage (batteries, fuel cell technology, etc.), power management and distribution, and power systems architecture and analysis. Such advanced technology is now being developed for small satellite and cubesat applications and could have a significant impact on the longevity and capabilities of these missions. A presentation during the Pre-Conference Workshop will focus on various advanced power technologies being developed and demonstrated by NASA, and their possible application within the small satellite community.

  7. Securing the smart grid information exchange

    Energy Technology Data Exchange (ETDEWEB)

    Fries, Steffen; Falk, Rainer [Siemens AG, Corporate Technology, Muenchen (Germany)

    2012-07-01

    The smart grid is based on information exchange between various stakeholders using open communication technologies, to control the physical electric grid through the information grid. Protection against cyber attacks is essential to ensure a reliable operation of the smart grid. This challenge is addressed by various regulatory, standardization, and research activities. After giving an overview of the security demand of a smart grid, existing and appearing standardization activities are described. (orig.)

  8. Activities of JAXA's Innovative Technology Center on Space Debris Observation

    Science.gov (United States)

    Yanagisawa, T.; Kurosaki, H.; Nakajima, A.

    The innovative technology research center of JAXA is developing observational technologies for GEO objects in order to cope with the space debris problem. The center had constructed the optical observational facility for space debris at Mt. Nyukasa, Nagano in 2006. As observational equipments such as CCD cameras and telescopes were set up, the normal observation started. In this paper, the detail of the facilities and its activities are introduced. The observational facility contains two telescopes and two CCD cameras. The apertures of the telescopes are 35cm and 25 cm, respectively. One CCD camera in which 2K2K chip is installed can observe a sky region of 1.3 times 1.3-degree using the 35cm telescope. The other CCD camera that contains two 4K2K chips has an ability to observe 2.6 times 2.6-degree's region with the 25cm telescope. One of our main objectives is to detect faint GEO objects that are not catalogued. Generally, the detection limit of GEO object is determined by the aperture of the telescope. However, by improving image processing techniques, the limit may become low. We are developing some image processing methods that use many CCD frames to detect faint objects. We are trying to use FPGA (Field Programmable Gate Array) system to reduce analyzing time. By applying these methods to the data taken by a large telescope, the detection limit will be significantly lowered. The orbital determination of detected GEO debris is one of the important things to do. Especially, the narrow field view of an optical telescope hinders us from re-detection of the GEO debris for the orbital determination. Long observation time is required for one GEO object for the orbital determination that is inefficient. An effective observation strategy should be considered. We are testing one observation method invented by Umehara that observes one inertia position in the space. By observing one inertia position for two nights, a GEO object that passed through the position in the

  9. Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix

    NARCIS (Netherlands)

    ten Klooster, Jean Paul; Jaffer, Zahara M.; Chernoff, Jonathan; Hordijk, Peter L.

    2006-01-01

    Rho guanosine triphosphatases (GTPases) are critical regulators of cytoskeletal dynamics and control complex functions such as cell adhesion, spreading, migration, and cell division. It is generally accepted that localized GTPase activation is required for the proper initiation of downstream

  10. Survey report of FY 1997 on the global environmental industry technology development promotion project. International research exchange project; 1997 nendo chosa hokokusho. Chikyu kankyo sangyo gijutsu kaihatsu suishin jigyo (kokusai kenkyu koryu jigyo)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-03-01

    Exchange of personnel among foreign research organizations is significant for promoting research and development to create new research fields and to build new technological systems for the purpose of solving global environmental problems. For this purpose, researchers were sent/invited to/from international conferences and international symposiums related to global environmental technology and exchange of personnel with major foreign research organizations and universities was conducted under the cooperation of RITE and RITE-related researchers and related academic societies. Based on short-term invitation and sending of researchers as well as the feasibility study of researcher exchange, researchers were sent/invited on long- and mid-terms. As a result, exchange of personnel engaged in the latest research in Japan and overseas could be promoted. It was found that various researches are being conducted abroad in basic areas of global environmental technology. Since they are closely related to the research and development of industrial technology contributing to global environmental preservation promoted by RITE, it is important to establish a more efficient exchange system of researchers in the future. 91 refs., 38 figs., 14 tabs.

  11. In-Frame and Unmarked Gene Deletions in Burkholderia cenocepacia via an Allelic Exchange System Compatible with Gateway Technology

    Science.gov (United States)

    Fazli, Mustafa; Harrison, Joe J.; Gambino, Michela; Givskov, Michael

    2015-01-01

    Burkholderia cenocepacia is an emerging opportunistic pathogen causing life-threatening infections in immunocompromised individuals and in patients with cystic fibrosis, which are often difficult, if not impossible, to treat. Understanding the genetic basis of virulence in this emerging pathogen is important for the development of novel treatment regimes. Generation of deletion mutations in genes predicted to encode virulence determinants is fundamental to investigating the mechanisms of pathogenesis. However, there is a lack of appropriate selectable and counterselectable markers for use in B. cenocepacia, making its genetic manipulation problematic. Here we describe a Gateway-compatible allelic exchange system based on the counterselectable pheS gene and the I-SceI homing endonuclease. This system provides efficiency in cloning homology regions of target genes and allows the generation of precise and unmarked gene deletions in B. cenocepacia. As a proof of concept, we demonstrate its utility by deleting the Bcam1349 gene, encoding a cyclic di-GMP (c-di-GMP)-responsive regulator protein important for biofilm formation. PMID:25795676

  12. Characterizing rapid, activity-linked conformational transitions in proteins via sub-second hydrogen deuterium exchange mass spectrometry.

    Science.gov (United States)

    Resetca, Diana; Wilson, Derek J

    2013-11-01

    This review outlines the application of time-resolved electrospray ionization mass spectrometry (TRESI-MS) and hydrogen-deuterium exchange (HDX) to study rapid, activity-linked conformational transitions in proteins. The method is implemented on a microfluidic chip which incorporates all sample-handling steps required for a 'bottom-up' HDX workflow: a capillary mixer for sub-second HDX labeling, a static mixer for HDX quenching, a microreactor for rapid protein digestion, and on-chip electrospray. By combining short HDX labeling pulses with rapid digestion, this approach provides a detailed characterization of the structural transitions that occur during protein folding, ligand binding, post-translational modification and catalytic turnover in enzymes. This broad spectrum of applications in areas largely inaccessible to conventional techniques means that microfluidics-enabled TRESI-MS/HDX is a unique and powerful approach for investigating the dynamic basis of protein function. © 2013 FEBS.

  13. Electrostatic stabilization and general base catalysis in the active site of the human protein disulfide isomerase a domain monitored by hydrogen exchange.

    Science.gov (United States)

    Hernández, Griselda; Anderson, Janet S; LeMaster, David M

    2008-03-25

    The nucleophilic Cys36 thiol of the human protein disulfide isomerase a domain is positioned over the N terminus of the alpha(2) helix. Amides in the active site exhibit diffusion-limited, hydroxide-catalyzed exchange, indicating that the local positive electrostatic potential decreases the pK value for peptide anion formation by at least 2 units so as to equal or exceed the acidity of water. In stark contrast to the pH dependence of exchange for simple peptides, the His38 amide in the reduced enzyme exhibits a maximum rate of exchange at pH 5 due to efficient general base catalysis by the neutral imidazole of its own side chain and suppression of its exchange by the ionization of the Cys36 thiol. Ionization of this thiol and deprotonation of the His38 side chain suppress the Cys39 amide hydroxide-catalyzed exchange by a million-fold. The electrostatic potential within the active site monitored by these exchange experiments provides a means of stabilizing the two distinct transition states that lead to substrate reduction and oxidation. Molecular modeling offers a role for the conserved Arg103 in coordinating the oxidative transition-state complex, thus providing further support for mechanisms of disulfide isomerization that utilize enzymatic catalysis at each step of the overall reaction.

  14. Application of nuclear technology for sustainable development, and IAEA activities

    International Nuclear Information System (INIS)

    Machi, Sueo

    1998-01-01

    The role of radiation and isotopes for sustainable development in improving agriculture, industry and environmental conservation is presented. The radiation and isotope technology can increase productivity in a sustainable way. The IAEA programmes encompass mutation breeding, soil fertility and crop production, animal production, food irradiation, agrochemicals and insect pest control using nuclear technology

  15. Science and technology of plasma activated direct wafer bonding

    Science.gov (United States)

    Roberds, Brian Edward

    This dissertation studied the kinetics of silicon direct wafer bonding with emphasis on low temperature bonding mechanisms. The project goals were to understand the topological requirements for initial bonding, develop a tensile test to measure the bond strength as a function of time and temperature and, using the kinetic information obtained, develop lower temperature methods of bonding. A reproducible surface metrology metric for bonding was best described by power spectral density derived from atomic force microscopy measurements. From the tensile strength kinetics study it was found that low annealing temperatures could be used to obtain strong bonds, but at the expense of longer annealing times. Three models were developed to describe the kinetics. A diffusion controlled model and a reaction rate controlled model were developed for the higher temperature regimes (T > 600sp°C), and an electric field assisted oxidation model was proposed for the low temperature range. An in situ oxygen plasma treatment was used to further enhance the field-controlled mechanism which resulted in dramatic increases in the low temperature bonding kinetics. Multiple internal transmission Fourier transform infrared spectroscopy (MIT-FTIR) was used to monitor species evolution at the bonded interface and a capacitance-voltage (CV) study was undertaken to investigate charge distribution and surface states resulting from plasma activation. A short, less than a minute, plasma exposure prior to contacting the wafers was found to obtain very strong bonds for hydrophobic silicon wafers at very low temperatures (100sp°C). This novel bonding method may enable new technologies involving heterogeneous material systems or bonding partially fabricated devices to become realities.

  16. Active and Passive Technology Integration: A Novel Approach for Managing Technology's Influence on Learning Experiences in Context-Aware Learning Spaces

    Science.gov (United States)

    Laine, Teemu H.; Nygren, Eeva

    2016-01-01

    Technology integration is the process of overcoming different barriers that hinder efficient utilisation of learning technologies. The authors divide technology integration into two components based on technology's role in the integration process. In active integration, the technology integrates learning resources into a learning space, making it…

  17. Treatment of alpha active organic liquid scintillator waste with ion exchange resins-column studies

    International Nuclear Information System (INIS)

    Venugopal Chetty, K.; Vaidya, V.N.; Venugopal, V.; Rao, P.R.V.

    2002-01-01

    The distribution ratios and percentage extraction for americium and total alpha due to plutonium and americium were determined using mixture of resins from the simulated alpha active organic liquid scintillator waste solution. Macroporous Bifunctional Phosphinic Acid (MPBPA) resin along with Amberlite IR-120 or AG 50WX8 in the ratios 1 : 1 to 1 : 6 were studied and the percentage extraction of better than 97% and distribution ratio of more than 480 were obtained. The data indicated the usefulness of these resins to remove alpha activity from these organic waste solutions. The column experiments were carried out using the active organic liquid scintillator waste with and without dilution with alcohol, and only alcoholic waste generated in the laboratory during the washing of the used liquid scintillator vials. The column containing either single MPBPA resin or with additional resin bed of Amberlite IR-120 were used for the treatment of the wastes. In the case of alcoholic waste after removal of activity it was reused for rinsing of the used vials. (author)

  18. A Review of Technology Education in Ireland; a Changing Technological Environment Promoting Design Activity

    Science.gov (United States)

    Leahy, Keelin; Phelan, Pat

    2014-01-01

    In Ireland, Technology Education's structure and organisation across the levels of education is not delivered or governed in a coherent manner. Technology Education in primary level education, for students between 5 and 12 years of age, does not explicitly exist as a separate subject. In primary level education, Social, Environmental and…

  19. Evaluation of the feasibility of security technologies in teleradiology as biometric fingerprint scanners for data exchange over a satellite WAN

    Science.gov (United States)

    Soegner, Peter I.; Helweg, Gernot; Holzer, Heimo; zur Nedden, Dieter

    2000-05-01

    We evaluated the feasibility of fingerprint-scanners in combination with smart cards for personal identification and transmission of encrypted TCP/IP-data-packages via satellite between the university-hospital of Innsbruck and the rural hospital of Reutte. The aim of our study was the proof of the userfriendliness of the SkymedTM technology for security purpose in teleradiology. We examined the time of the personal identification process, the time for the necessary training and the personal satisfaction. The images were sent from the local PACS in Reutte via a Data-Encryption-and-Transmission- Box via satellite from Reutte to Innsbruck. We used an asymmetric bandwidth of 512 kbit/s from Reutte to Innsbruck and 128 kbit/s in the opposite direction. Window NT 4.0- operating PCs were used for the electronical patient record, the medical inquiry of the referring physician and the final report of the radiologist. The images were reported on an UNIX-PACS viewing station. After identification through fingerprint-scanners in combination with the smart card the radiologist was able to open the electronic patient record (EPR) from Reutte and sign with his digital signature his confirmed final report before it was send back to Reutte. The used security technology enables encrypted communication over a WAN, which fulfill data-protection.

  20. Hydrogen/Deuterium Exchange Mass Spectrometry Reveals Mechanistic Details of Activation of Nucleoside Diphosphate Kinases by Oligomerization.

    Science.gov (United States)

    Dautant, Alain; Meyer, Philippe; Georgescauld, Florian

    2017-06-13

    Most oligomeric proteins become active only after assembly, but why oligomerization is required to support function is not well understood. Here, we address this question using the wild type (WT) and a destabilized mutant (D93N) of the hexameric nucleoside diphosphate kinase from the pathogen Mycobacterium tuberculosis (Mt-NDPK). The conformational dynamics and oligomeric states of each were analyzed during unfolding and/or folding by hydrogen/deuterium exchange mass spectrometry (HDX-MS) at peptide resolution and by additional biochemical techniques. We found that WT and D93N native hexamers present a stable core and a flexible periphery, the latter being more flexible for the destabilized mutant. Stable but inactive species formed during unfolding of D93N and folding of WT were characterized. For the first time, we show that both of these species are nativelike dimers, each of its monomers having a major subdomain folded, while a minor subdomain (Kpn/α 0 ) remains unfolded. The Kpn/α 0 subdomain, which belongs to the catalytic site, becomes structured only upon hexamerization, explaining why oligomerization is required for NDPK activity. Further HDX-MS studies are necessary to establish the general activation mechanism for other homo-oligomers.

  1. Simulation of corrosion product activity in ion- exchanger of PWR under acceleration of corrosion and flow rate perturbations

    International Nuclear Information System (INIS)

    Mirza, N.M.; Mirza, S.M.; Rafique, M.

    2005-01-01

    In this paper computer code developed earlier by the authors (CPAIR-P) has been employed to compute corrosion product activity in PWRs for flow rate perturbations. The values of radioactivity in ion exchanger of Pressurized Water Reactor (PWR) under normal and flow rate perturbation conditions have been calculated. For linearly accelerating corrosion rates, activity saturates for removal rate of 600 cm/sup 3// s in primary coolant of PWR. A higher removal rate of 750 cm/sup 3// s was selected for which the saturation value is sufficiently low (0. 28 micro Ci/cm/sup 3/). Simulation results shows that the Fe/sup 59/ Na/sup 24/, Mo/sup 99/, Mn/sup 56/ reaches saturation values with in about 700 hours of reactor operation. However, Co/sup 58/ and Co/sup 60/ keep on accumulating and do not saturate with in 2000 hours of these simulation time. When flow rate is decreased by 10% of rated flow rate after 500 hours of reactor operation, a dip in activity is seen, which reaches to the value of 0.00138 micro Ci cm/sup -3/ then again it begins to rise and reaches saturation value of 0.00147 cm/sup 3//s. (author)

  2. Activation of protein kinase A and exchange protein directly activated by cAMP promotes adipocyte differentiation of human mesenchymal stem cells

    DEFF Research Database (Denmark)

    Jia, Bingbing; Madsen, Lise; Petersen, Rasmus Koefoed

    2012-01-01

    ) and exchange protein directly activated by cAMP (Epac) in adipocyte conversion of human mesenchymal stem cells derived from adipose tissue (hMADS). We show that cAMP signaling involving the simultaneous activation of both PKA- and Epac-dependent signaling is critical for this process even in the presence......Human mesenchymal stem cells are primary multipotent cells capable of differentiating into several cell types including adipocytes when cultured under defined in vitro conditions. In the present study we investigated the role of cAMP signaling and its downstream effectors, protein kinase A (PKA...... results emphasize the need for cAMP signaling in concert with treatment with a PPARγ or PPARδ agonist to secure efficient adipocyte differentiation of human hMADS mesenchymal stem cells....

  3. Scientific and Technological Information Activity in China (White Paper on Science and Technology : No.1, 1986.5)

    Science.gov (United States)

    Translated By Joho Kanri Editorial Committee

    This is a translation of Chapter 4 : Information Systems of Volume 5 : Environment and Resources in the first number of White Paper on Science and Technology edited in May 1986 by State Scientific and Technological Commission (SSTC). Scientific and technological information activity in China has progressed by keeping close cooperation among the Institute for Scientific and Technological Information in China (ISTIC) as a core organization, 33 information institutes under the control of each ministrial commission of The State Council and 35 information institutes of the local governments and cities. As a result of having promoted the information activities along with the guiding principle decided by the 5th National Conference on Scientific and Technological Information in July 1980, information business could be made a great contribution to political decision, national projects and economy stressing plan, technology introduction, etc. The Scientific and Technological Information Bureau of SSTC as a coordinating body proposed the following subjects as an important item for promoting future information business in China: standardization of abstract journals, bringing up of investigators and researchers, production of data bases and consolidation of international online retrieval services, step by step introduction of a charging system for information service, etc.

  4. A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange

    DEFF Research Database (Denmark)

    Liu, Yi; Dentin, Renaud; Chen, Danica

    2008-01-01

    During early fasting, increases in skeletal muscle proteolysis liberate free amino acids for hepatic gluconeogenesis in response to pancreatic glucagon. Hepatic glucose output diminishes during the late protein-sparing phase of fasting, when ketone body production by the liver supplies compensatory...... expression through the dephosphorylation and nuclear shuttling of forkhead box O1 (FOXO1). Here we show that a fasting-inducible switch, consisting of the histone acetyltransferase p300 and the nutrient-sensing deacetylase sirtuin 1 (SIRT1), maintains energy balance in mice through the sequential induction...... of CRTC2 and FOXO1. After glucagon induction, CRTC2 stimulated gluconeogenic gene expression by an association with p300, which we show here is also activated by dephosphorylation at Ser 89 during fasting. In turn, p300 increased hepatic CRTC2 activity by acetylating it at Lys 628, a site that also...

  5. How Does Technology-Enabled Active Learning Affect Undergraduate Students' Understanding of Electromagnetism Concepts?

    Science.gov (United States)

    Dori, Yehudit Judy; Belcher, John

    2005-01-01

    Educational technology supports meaningful learning and enables the presentation of spatial and dynamic images, which portray relationships among complex concepts. The Technology-Enabled Active Learning (TEAL) Project at the Massachusetts Institute of Technology (MIT) involves media-rich software for simulation and visualization in freshman…

  6. Operating revenue changes in a demutualized stock exchange

    Directory of Open Access Journals (Sweden)

    Mohamed Hesham Abdel-Hafez

    2015-03-01

    Full Text Available Stock exchanges were traditionally run as cooperative venues. The globalization, the development of technology, and the increase of competition among stock exchanges forced these venues to change their structure and adopt a new one-demutualization- that can be a lifeline in facing these environmental changes in regards to stock exchanges. This new trend enables the exchange to expand their activities and supply the market with new products and services, therefore enhancing the value of the exchange itself. The main sources of revenue for traditional exchanges have been listing fees, transaction fees, membership fees and the sale of information services such as market data, quotations, and trade data. Due to the environmental changes the stock exchanges' services are now executed electronically, and in turn, this has led to an increase in the competition among exchanges. Furthermore, this increased competition has led to the re-adjustment of the regulation structure which gradually erodes the sources of revenues provided by the conventional stock exchanges. The paper divided the research plan into two sections: the first section is to highlight the concept of demutualization process; the phases of demutualization, the factors that push the stock exchanges to demutualize and the benefits of demutualization. The second section was based on statistical comparative analysis of the stock exchanges' revenues prior and after demutualization. The researcher used the regression analysis tool on seven demutualized stock exchanges during the period from 1997-2012. The paper aims to prove that demutualization has a positive effect on the revenues of the stock exchange, thus it enhances the value of the exchange.

  7. TECHNOLOGIES OF INITIATING STUDENTS INTO INDEPENDENT (SELF-GUIDED ACTIVITY IN SUPPLEMENTARY DISTANCE LEARNING

    Directory of Open Access Journals (Sweden)

    Irina V. Abakumova

    2016-12-01

    Full Text Available The research in question investigates the technologies of initiating independent activity within the framework of distance learning and their psychological aspects. The authors’ classification of educational technologies of initiating students into independent cognitive activity is presented. Such technologies utilize various psychological mechanisms of exciting students’ cognitive interest, intensifying cognitive processes, developing independent activity skills, and, as a result, increase motivation for independent activity and learning on the whole. These include such types of technologies as developmental technologies, interactive technologies, technologies of information transfer, technologies of meaning-making initiation. The research of the attitude of distance learning educators to independent activity of students and the content of the academic courses were done at Moodle-based education programs. The findings show the differences in retention rate among distance learning educators whose competence in terms of initiating students into independent (self-guided activity varies. It’s emphasized that interactive lectures, videoconferences, audio-visual aids, interactive seminars, glossaries, interactive tests are considered the most efficient technologies in initiating students into independent (self-guided activity. The obtained results have made it possible to stress the developmental effect of distance learning technologies and the technologies of initiating students into independent (self-guided activity in various psychic spheres of students: cognitive, individual, emotional. We mention the changes in motivational sphere of students and their meaning-making activity. In the course of correct development of distance learning we notice the development of voluntary and nonvoluntary cognitive activity. A student starts actively participating in educational process, he becomes the creator of his own world.

  8. Initial rate and equilibrium isotope exchange studies on the ATP-dependent activity of polyphosphate Glucokinase from Propionibacterium shermanii.

    Science.gov (United States)

    Kowalczyk, T H; Horn, P J; Pan, W H; Phillips, N F

    1996-05-28

    Polyphosphate glucokinase [EC 2.7.1.63] catalyzes the phosphorylation of glucose using either inorganic polyphosphate [poly(P)] or ATP as the phosphoryl donor. Both activities purified from Propionibacterium shermanii are the functional properties of a single enzyme with separate binding sites for the two phosphoryl donor substrates. The enzyme was found to utilize poly(P) much more efficiently than it does ATP, with a kcat/Kpoly(P) to kcat/KATP ratio of 2800. The catalytic constant for poly(P) is about 2-fold higher than for ATP. Other nucleotides like GTP and dATP also served as substrates with good efficiencies. The ATP-dependent reaction was analyzed using steady-state kinetics and isotopic exchange kinetics at chemical equilibrium. Intersecting initial velocity patterns for both glucose and ATP indicate sequential addition of substrates. Product inhibition studies resulted in two competitive and two noncompetitive patterns, which is characteristic of a Theorell-Chance mechanism or a random mechanism with two dead-end complexes. Results of isotope exchange experiments, however, rule out a Theorell-Chance mechanism, as well as a truly random mechanism. They are not consistent with a partially random mechanism (although a kinetically compulsory order of substrate binding is not excluded), where glucose is preferentially bound to free enzyme before ATP, and ADP is preferentially released as the first product, followed by glucose 6-phosphate. Dead-end inhibition analysis confirms this order of substrate binding. Competitive inhibition of ADP vs ATP is explained as resulting primarily from binding as a dead-end inhibitor (E.Glc.ADP) and not as a product. Another weaker abortive complex, E.ATP.G6P, is also formed. The chemical transformation or the release of ADP is the rate-limiting step in ATP utilization.

  9. Guidelines on Active Content and Mobile Code: Recommendations of the National Institute of Standards and Technology

    National Research Council Canada - National Science Library

    Jansen, Wayne

    2001-01-01

    .... One such category of technologies is active content. Broadly speaking, active content refers to electronic documents that, unlike past character documents based on the American Standard Code for Information Interchange (ASCII...

  10. Neutron activation analysis of Lerna ceramics (Greece) at Early Bronze Age: local production and trade exchanges

    International Nuclear Information System (INIS)

    Attas, M.

    1980-01-01

    Neutron activation analysis is a powerful tool for determining the provenance of ancient ceramics. A sophisticated analytical system for gamma-ray spectrometry, designed specifically for the chemical analysis of ceramics by thermal neutron activation, was used to determine the concentrations of twenty elements in samples of ancient pottery. The measurements were made relative to the standard pottery of Perlman and Asaro. The purpose of the work was to study the production of fine pottery at the settlement of Lerna, in the Argolid of Greece, during the Early Bronze Age (third millennium BC). About half of the 50 samples analysed formed the major compositional group, which was attributed to Lerna. It included, besides the majority of the samples from the second phase of the Early Bronze Age (Lerna III), several samples from the third phase (Lerna IV); that is, from levels immediately succeeding the great destruction which marks the end of the Lerna III settlement. A small number of objects forms a second group of local origin and includes 4 of the 5 clay sealings sampled. Among the archaeologically unusual objects, several could be attributed to Lerna, while others were characterized as imports [fr

  11. Salicylic acid confers salt tolerance in potato plants by improving water relations, gaseous exchange, antioxidant activities and osmoregulation.

    Science.gov (United States)

    Faried, Hafiz Nazar; Ayyub, Chaudhary Muhammad; Amjad, Muhammad; Ahmed, Rashid; Wattoo, Fahad Masoud; Butt, Madiha; Bashir, Mohsin; Shaheen, Muhammad Rashid; Waqas, Muhammad Ahmed

    2017-04-01

    Potato is an important vegetable; however, salt stress drastically affects its growth and yield. A pot experiment was therefore conducted to assess salicylic acid efficacy in improving performance of potato cultivars, grown under salt stress (50 mmol L -1 ). Salicylic acid at 0.5 mmol L -1 was sprayed on to potato plants after 1 week of salinity application. Salt stress effects were ameliorated by salicylic acid effectively in both the studied cultivars. N-Y LARA proved more responsive to salicylic acid application than 720-110 NARC, which confirmed genetic variation between cultivars. Salicylic acid scavenged reactive oxygen species by improving antioxidant enzyme activities (superoxide dismutase, catalase, peroxidases) and regulating osmotic adjustment (proline, phenolic contents), which led to enhanced water relation and gaseous exchange attributes, and thereby increased potassium availability and reduced sodium content in potato leaves. Moreover, potato tuber yield showed a positive correlation with potassium content, photosynthesis and antioxidant enzyme activities. Salt tolerance efficacy of salicylic acid is authenticated in improving potato crop performance under salt stress. Salicylic acid effect was more pronounced in N-Y LARA, reflecting greater tolerance than 720-110 NARC, which was confirmed as a susceptible cultivar. Hence salicylic acid at 0.5 mmol L -1 and cultivation of N-Y LARA may be recommended in saline soil. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.

  12. Formation of carbon nanosheets via simultaneous activation and catalytic carbonization of macroporous anion-exchange resin for supercapacitors application.

    Science.gov (United States)

    Peng, Hui; Ma, Guofu; Sun, Kanjun; Mu, Jingjing; Zhang, Zhe; Lei, Ziqiang

    2014-12-10

    Two-dimensional mesoporous carbon nanosheets (CNSs) have been prepared via simultaneous activation and catalytic carbonization route using macroporous anion-exchange resin (AER) as carbon precursor and ZnCl2 and FeCl3 as activating agent and catalyst, respectively. The iron catalyst in the skeleton of the AER may lead to carburization to form a sheetlike structure during the carbonization process. The obtained CNSs have a large number of mesopores, a maximum specific surface area of 1764.9 m(2) g(-1), and large pore volume of 1.38 cm(3) g(-1). As an electrode material for supercapacitors application, the CNSs electrode possesses a large specific capacitance of 283 F g(-1) at 0.5 A g(-1) and excellent rate capability (64% retention ratio even at 50 A g(-1)) in 6 mol L(-1) KOH. Furthermore, CNSs symmetric supercapacitor exhibits specific energies of 17.2 W h kg(-1) at a power density of 224 W kg(-1) operated in the voltage range of 0-1.8 V in 0.5 mol L(-1) Na2SO4 aqueous electrolyte, and outstanding cyclability (retains about 96% initial capacitance after 5000 cycles).

  13. Activity-regulating structural changes and autoantibody epitopes in transglutaminase 2 assessed by hydrogen/deuterium exchange.

    Science.gov (United States)

    Iversen, Rasmus; Mysling, Simon; Hnida, Kathrin; Jørgensen, Thomas J D; Sollid, Ludvig M

    2014-12-02

    The multifunctional enzyme transglutaminase 2 (TG2) is the target of autoantibodies in the gluten-sensitive enteropathy celiac disease. In addition, the enzyme is responsible for deamidation of gluten peptides, which are subsequently targeted by T cells. To understand the regulation of TG2 activity and the enzyme's role as an autoantigen in celiac disease, we have addressed structural properties of TG2 in solution by using hydrogen/deuterium exchange monitored by mass spectrometry. We demonstrate that Ca(2+) binding, which is necessary for TG2 activity, induces structural changes in the catalytic core domain of the enzyme. Cysteine oxidation was found to abolish these changes, suggesting a mechanism whereby disulfide bond formation inactivates the enzyme. Further, by using TG2-specific human monoclonal antibodies generated from intestinal plasma cells of celiac disease patients, we observed that binding of TG2 by autoantibodies can induce structural changes that could be relevant for the pathogenesis. Detailed mapping of two of the main epitopes targeted by celiac disease autoantibodies revealed that they are located adjacent to each other in the N-terminal part of the TG2 molecule.

  14. Highly Stable and Active Pt/Nb-TiO2 Carbon-Free Electrocatalyst for Proton Exchange Membrane Fuel Cells

    Directory of Open Access Journals (Sweden)

    Shuhui Sun

    2012-01-01

    Full Text Available The current materials used in proton exchange membrane fuel cells (PEMFCs are not sufficiently durable for commercial deployment. One of the major challenges lies in the development of an inexpensive, efficient, and highly durable and active electrocatalyst. Here a new type of carbon-free Pt/Nb-TiO2 electrocatalyst has been reported. Mesoporous Nb-TiO2 hollow spheres were synthesized by the sol-gel method using polystyrene (PS sphere templates. Pt nanoparticles (NPs were then deposited onto mesoporous Nb-TiO2 hollow spheres via a simple wet-chemical route in aqueous solution, without the need for surfactants or potentiostats. The growth densities of Pt NPs on Nb-TiO2 supports could be easily modulated by simply adjusting the experimental parameters. Electrochemical studies of Pt/Nb-TiO2 show much enhanced activity and stability than commercial E-TEK Pt/C catalyst. PtNP/Nb-TiO2 is a promising new cathode catalyst for PEMFC applications.

  15. Oil atlas: National Petroleum Technology Office activities across the United States

    Energy Technology Data Exchange (ETDEWEB)

    Tiedemann, H.A.

    1998-03-01

    Petroleum imports account for the largest share of the US trade deficit. Over one-third of the 1996 merchandise trade deficit is attributed to imported oil. The good news is that substantial domestic oil resources, both existing and yet-to-be-discovered, can be recovered using advanced petroleum technologies. The Energy Information Agency estimates that advanced technologies can yield 10 billion additional barrels, equal to $240 billion in import offsets. The US Department of Energy`s National Petroleum Technology Office works with industry to develop advanced petroleum technologies and to transfer successful technologies to domestic oil producers. This publication shows the locations of these important technology development efforts and lists DOE`s partners in this critical venture. The National Petroleum Technology Office has 369 active technology development projects grouped into six product lines: Advanced Diagnostics and Imaging Systems; Advanced Drilling, Completion, and Stimulation; Reservoir Life Extension and Management; Emerging Processing Technology Applications; Effective Environmental Protection; and Crosscutting Program Areas.

  16. Game Changing Development Program - Next Generation Life Support Project: Oxygen Recovery From Carbon Dioxide Using Ion Exchange Membrane Electrolysis Technology

    Science.gov (United States)

    Burke, Kenneth A.; Jiao, Feng

    2016-01-01

    This report summarizes the Phase I research and development work performed during the March 13, 2015 to July 13, 2016 period. The proposal for this work was submitted in response to NASA Research Announcement NNH14ZOA001N, "Space Technology Research, Development, Demonstration, and Infusion 2014 (SpaceTech-REDDI-2014)," Appendix 14GCD-C2 "Game Changing Development Program, Advanced Oxygen Recovery for Spacecraft Life Support Systems Appendix" The Task Agreement for this Phase I work is Document Control Number: GCDP-02-TA-15015. The objective of the Phase I project was to demonstrate in laboratories two Engineering Development Units (EDU) that perform critical functions of the low temperature carbon dioxide electrolysis and the catalytic conversion of carbon monoxide into carbon and carbon dioxide. The low temperature carbon dioxide electrolysis EDU was built by the University of Delaware with Dr. Feng Jiao as the principal investigator in charge of this EDU development (under NASA Contract NNC15CA04C). The carbon monoxide catalytic conversion EDU was built by the NASA Glenn Research Center with Kenneth Burke as the principal investigator and overall project leader for the development of both EDUs. Both EDUs were successfully developed and demonstrated the critical functions for each process. The carbon dioxide electrolysis EDU was delivered to the NASA Johnson Space Center and the carbon monoxide catalytic conversion EDU was delivered to the NASA Marshall Spaceflight Center.

  17. Heat exchanger

    International Nuclear Information System (INIS)

    Dostatni, A.W.; Dostatni, Michel.

    1976-01-01

    In the main patent, a description was given of a heat exchanger with an exchange surface in preformed sheet metal designed for the high pressure and temperature service particularly encountered in nuclear pressurized water reactors and which is characterised by the fact that it is composed of at least one exchanger bundle sealed in a containment, the said bundle or bundles being composed of numerous juxtaposed individual compartments whose exchange faces are built of preformed sheet metal. The present addendun certificate concerns shapes of bundles and their positioning methods in the exchanger containment enabling its compactness to be increased [fr

  18. Complementarities between organizational changes, R&D activity and technological cooperation for the French manufacturing firms

    OpenAIRE

    Hajjem, Olfa; Ayadi, Mohamed; Garrouste, Pierre

    2011-01-01

    This article analyzes the determinants of the French companies’ innovation activity while highlighting the importance and the complementarities of the organizational and technological practices’impact. Our results suggest on one hand, that the product or process innovation is determined by the internal and external attributes of the company (size, demand pull and technological class). On the other hand, the complementarities tests between the technological (R&D activity and ...

  19. Experimental research of technology activating catalysts for SCR DeNOx in boiler

    Science.gov (United States)

    Zeng, Xi; Yang, Zhengde; Li, Yan; Chen, Donglin

    2018-01-01

    In order to improve activity of the catalysts used in SCR DeNOx system of flue gas, a series of catalysts activated by different activating liquids under varied conditions in boiler directly were conducted. Then these catalysts were characterized by SEM, FT-IR and BET technology. And NO conversions of the activated catalysts were studied and compared with that of inactivated catalyst. The above experiment shows that NO conversion of the activated catalyst can be up to 99%, which 30% higher than that of inactivated catalyst, so activity of catalysts were improved greatly. Furthermore, optimal activating liquid labeled L2 and effective technology parameters were gained in the experiment.

  20. Sensing technologies to measure metabolic activities in soil and assess its health conditions

    Science.gov (United States)

    De Cesare, Fabrizio; Macagnano, Antonella

    2013-04-01

    (olfactory fingerprint) typical of the analysed air sample. Due to these features, we decided to apply such a sensing technology to the analyses of soil atmospheres, because several processes in soil, both abiotic and biotic, result in gas and/or volatile production and the dynamics of such releases may also be affected by several additional environmental factors, such as soil moisture, temperature, gas exchange rates with outer atmosphere, adsorption/desorption processes, etc. Then, the analysis of soil atmosphere may provide information about global soil conditions (e.g. soil quality and health), according to a holistic approach, where several factors are contemporarily taken into account. At the same time, the use of such a technology, if adequately trained on purpose, can supply information about a single or a pool of processes sharing similar features, which occur in soil over a certain period of time and mostly affecting soil atmosphere. According to these premises and hypotheses, we demonstrated that EN is an useful technology to measure soil microbial activity, through its correlation to specific metabolic activities occurring in soil (i.e. global and specific respiration and some enzyme activities), but also soil microbial biomass. On the basis of such evidences, we also were able to use this technology to assess the quality and health conditions of soil ecosystems in terms of metabolic indices previously identified, according to some metabolic parameters and biomass quantification of microbial populations. In other studies, we also applied EN technology, despite using a different set of sensors in the array, to analyse the atmosphere of soil ecosystems in order to assess their environmental conditions after contamination with polycyclic aromatic hydrocarbons (PAHs) (i.e. semivolatile - SVOCs - organic pollutants). In this case, EN technology resulted capable of distinguishing between contaminated and uncontaminated soils, according to the differences in a list of

  1. The Green Revolution in Transportation. Resource Recovery. Technology Learning Activities.

    Science.gov (United States)

    Technology Teacher, 1991

    1991-01-01

    These two learning activities provide context, objectives, list of materials, student activity, and evaluation criteria. The first involves an automotive class in developing a model alternative fueled vehicle, and the second involves the design of a useful recyclable product. (JOW)

  2. Thermoregulation and heat exchange in a nonuniform thermal environment during simulated extended EVA. Extravehicular activities

    Science.gov (United States)

    Koscheyev, V. S.; Leon, G. R.; Hubel, A.; Nelson, E. D.; Tranchida, D.

    2000-01-01

    BACKGROUND: Nonuniform heating and cooling of the body, a possibility during extended duration extravehicular activities (EVA), was studied by means of a specially designed water circulating garment that independently heated or cooled the right and left sides of the body. The purpose was to assess whether there was a generalized reaction on the finger in extreme contradictory temperatures on the body surface, as a potential heat status controller. METHOD: Eight subjects, six men and two women, were studied while wearing a sagittally divided experimental garment with hands exposed in the following conditions: Stage 1 baseline--total body garment inlet water temperature at 33 degrees C; Stage 2--left side inlet water temperature heated to 45 degrees C; right side cooled to 8 degrees C; Stage 3--left side inlet water temperature cooled to 8 degrees C, right side heated to 45 degrees C. RESULTS: Temperatures on each side of the body surface as well as ear canal temperature (Tec) showed statistically significant Stage x Side interactions, demonstrating responsiveness to the thermal manipulations. Right and left finger temperatures (Tfing) were not significantly different across stages; their dynamic across time was similar. Rectal temperature (Tre) was not reactive to prevailing cold on the body surface, and therefore not informative. Subjective perception of heat and cold on the left and right sides of the body was consistent with actual temperature manipulations. CONCLUSIONS: Tec and Tre estimates of internal temperature do not provide accurate data for evaluating overall thermal status in nonuniform thermal conditions on the body surface. The use of Tfing has significant potential in providing more accurate information on thermal status and as a feedback method for more precise thermal regulation of the astronaut within the EVA space suit.

  3. An overview of NASA's activities in micro-nano technologies

    Science.gov (United States)

    Stocky, J. F.

    2000-01-01

    An examination of how mass is used in spacecraft design indicates that technology efforts directed only to reduce the mass of electronics, both digital and analog will not significantly reduce the mass of a spacecraft, regardless of how much success those efforts achieve.

  4. Wonderful Webcams: About Active Gazes and Invisible Technologies

    NARCIS (Netherlands)

    Pols, Jeannette

    2011-01-01

    How do technologies such as webcams influence health care and what concepts may describe this? This article explores the literature and analyses what people looking through webcams do within a particular health care practice in the Netherlands, that is, within the rehabilitation of people suffering

  5. Active Learning Methods and Technology: Strategies for Design Education

    Science.gov (United States)

    Coorey, Jillian

    2016-01-01

    The demands in higher education are on the rise. Charged with teaching more content, increased class sizes and engaging students, educators face numerous challenges. In design education, educators are often torn between the teaching of technology and the teaching of theory. Learning the formal concepts of hierarchy, contrast and space provide the…

  6. Low temperature activation of methane over a zinc-exchanged heteropolyacid as an entry to its selective oxidation to methanol and acetic acid

    KAUST Repository

    Patil, Umesh

    2014-01-01

    A Zn-exchanged heteropolyacid supported onto silica (Zn-HPW/SiO2) activates methane at 25 °C into Zn-methyl. At higher temperatures and with CH4/O2 or CH4/CO2, it gives methanol and acetic acid respectively. This journal is

  7. An innovative treatment concept for future drinking water production : Fluidized ion exchange – ultrafiltration – nanofiltration – granular activated carbon filtration

    NARCIS (Netherlands)

    Li, S.; Heijman, S.G.J.; Verberk, J.Q.J.C.; Van Dijk, J.C.

    2009-01-01

    A new treatment concept for drinking water production from surface water has been investigated on a pilot scale. The treatment concept consists of fluidized ion exchange (FIEX), ultrafiltration (UF), nanofiltration (NF), and granular activated carbon filtration (GAC). The FIEX process removed

  8. Networking activities in technology-based entrepreneurial teams

    DEFF Research Database (Denmark)

    Neergaard, Helle

    2005-01-01

    Based on social network theoy, this article investigates the distribution of networking roles and responsibilities in entrepreneurial founding teams. Its focus is on the team as a collection of individuals, thus allowing the research to address differences in networking patterns. It identifies six...... central networking activities and shows that not all founding team members are equally active 'networkers'. The analyses show that team members prioritize different networking activities and that one member in particular has extensive networking activities whereas other memebrs of the team are more...... limited in their networking, while some even reject the notion of networking as a useful activity....

  9. Iodine adsorption on ion-exchange resins and activated carbons: batch testing

    International Nuclear Information System (INIS)

    Parker, Kent E.; Golovich, Elizabeth C.; Wellman, Dawn M.

    2014-01-01

    Iodine sorption onto seven resins and six carbon materials was evaluated using water from well 299-W19-36 on the Hanford Site. These materials were tested using a range of solution-to-solid ratios. The test results are as follows. The efficacy of the resin and granular activated carbon materials was less than predicted based on manufacturers' performance data. It is hypothesized that this is due to the differences in speciation previously determined for Hanford groundwater. The sorption of iodine is affected by the iodine species in the source water. Iodine loading on resins using source water ranged from 1.47 to 1.70 µg/g with the corresponding K d values from 189.9 to 227.0 mL/g. The sorption values when the iodine is converted to iodide ranged from 2.75 to 5.90 µg/g with the corresponding K d values from 536.3 to 2979.6 mL/g. It is recommended that methods to convert iodine to iodide be investigated in fiscal year (FY) 2015. The chemicals used to convert iodine to iodate adversely affected the sorption of iodine onto the carbon materials. Using as-received source water, loading and K d values ranged from 1.47 to 1.70 µg/g and 189.8 to 226.3 mL/g respectively. After treatment, loading and K d values could not be calculated because there was little change between the initial and final iodine concentration. It is recommended the cause of the decrease in iodine sorption be investigated in FY15. In direct support of CH2M HILL Plateau Remediation Company, Pacific Northwest National Laboratory has evaluated samples from within the 200W pump and treat bioreactors. As part of this analysis, pictures taken within the bioreactor reveal a precipitate that, based on physical properties and known aqueous chemistry, is hypothesized to be iron pyrite or chalcopyrite, which could affect iodine adsorption. It is recommended these materials be tested at different solution-to-solid ratios in FY15 to determine their effect on iodine sorption.

  10. Iodine adsorption on ion-exchange resins and activated carbons: batch testing

    Energy Technology Data Exchange (ETDEWEB)

    Parker, Kent E.; Golovich, Elizabeth C.; Wellman, Dawn M.

    2014-09-30

    Iodine sorption onto seven resins and six carbon materials was evaluated using water from well 299-W19-36 on the Hanford Site. These materials were tested using a range of solution-to-solid ratios. The test results are as follows. The efficacy of the resin and granular activated carbon materials was less than predicted based on manufacturers’ performance data. It is hypothesized that this is due to the differences in speciation previously determined for Hanford groundwater. The sorption of iodine is affected by the iodine species in the source water. Iodine loading on resins using source water ranged from 1.47 to 1.70 µg/g with the corresponding Kd values from 189.9 to 227.0 mL/g. The sorption values when the iodine is converted to iodide ranged from 2.75 to 5.90 µg/g with the corresponding Kd values from 536.3 to 2979.6 mL/g. It is recommended that methods to convert iodine to iodide be investigated in fiscal year (FY) 2015. The chemicals used to convert iodine to iodate adversely affected the sorption of iodine onto the carbon materials. Using as-received source water, loading and Kd values ranged from 1.47 to 1.70 µg/g and 189.8 to 226.3 mL/g respectively. After treatment, loading and Kd values could not be calculated because there was little change between the initial and final iodine concentration. It is recommended the cause of the decrease in iodine sorption be investigated in FY15. In direct support of CH2M HILL Plateau Remediation Company, Pacific Northwest National Laboratory has evaluated samples from within the 200W pump and treat bioreactors. As part of this analysis, pictures taken within the bioreactor reveal a precipitate that, based on physical properties and known aqueous chemistry, is hypothesized to be iron pyrite or chalcopyrite, which could affect iodine adsorption. It is recommended these materials be tested at different solution-to-solid ratios in FY15 to determine their effect on iodine

  11. Small Column Ion Exchange

    International Nuclear Information System (INIS)

    Huff, Thomas

    2010-01-01

    Small Column Ion Exchange (SCIX) leverages a suite of technologies developed by DOE across the complex to achieve lifecycle savings. Technologies are applicable to multiple sites. Early testing supported multiple sites. Balance of SRS SCIX testing supports SRS deployment. A forma Systems Engineering Evaluation (SEE) was performed and selected Small Column Ion Exchange columns containing Crystalline Silicotitanate (CST) in a 2-column lead/lag configuration. SEE considered use of Spherical Resorcinol-Formaldehyde (sRF). Advantages of approach at SRS include: (1) no new buildings, (2) low volume of Cs waste in solid form compared to aqueous strip effluent; and availability of downstream processing facilities for immediate processing of spent resin.

  12. A high throughput gas exchange screen for determining rates of photorespiration or regulation of C4 activity.

    Science.gov (United States)

    Bellasio, Chandra; Burgess, Steven J; Griffiths, Howard; Hibberd, Julian M

    2014-07-01

    Large-scale research programmes seeking to characterize the C4 pathway have a requirement for a simple, high throughput screen that quantifies photorespiratory activity in C3 and C4 model systems. At present, approaches rely on model-fitting to assimilatory responses (A/C i curves, PSII quantum yield) or real-time carbon isotope discrimination, which are complicated and time-consuming. Here we present a method, and the associated theory, to determine the effectiveness of the C4 carboxylation, carbon concentration mechanism (CCM) by assessing the responsiveness of V O/V C, the ratio of RuBisCO oxygenase to carboxylase activity, upon transfer to low O2. This determination compares concurrent gas exchange and pulse-modulated chlorophyll fluorescence under ambient and low O2, using widely available equipment. Run time for the procedure can take as little as 6 minutes if plants are pre-adapted. The responsiveness of V O/V C is derived for typical C3 (tobacco, rice, wheat) and C4 (maize, Miscanthus, cleome) plants, and compared with full C3 and C4 model systems. We also undertake sensitivity analyses to determine the impact of R LIGHT (respiration in the light) and the effectiveness of the light saturating pulse used by fluorescence systems. The results show that the method can readily resolve variations in photorespiratory activity between C3 and C4 plants and could be used to rapidly screen large numbers of mutants or transformants in high throughput studies. © The Author 2014. Published by Oxford University Press on behalf of the Society for Experimental Biology.

  13. Interdependence between Logistics Activities and Information Communication Technologies (ICT

    Directory of Open Access Journals (Sweden)

    Evelin Vatovec Krmac

    2007-03-01

    Full Text Available With the growing trend toward the use of intema tiona/ supplychains and e-commerce, logistics service providers for productwarehousing, transportation and delivery are placinggreater emphasis on infomwtion communication technologies(ICT in order to remain competitive globally. In the last decades,innovative ICT have deeply affected the way business ispeJformed and the way that organizations compete. Innovationsin electronic commerce play a key role in managinginter-organizational networks of supply chain members. Theintemet represents a powerful technology for commerce andcommunication between supply chain participants as well as atechnique for the improvement of supply chain management.But there are still some barriers that prevent the use of ICT insupply chains and consequently the ability to utilize all potentialICT advantages.

  14. Overview on R and D and design activities for the ITER core charge exchange spectroscopy diagnostic system

    Energy Technology Data Exchange (ETDEWEB)

    Biel, W., E-mail: w.biel@fz-juelich.de [Institut fuer Energieforschung - Plasmaphysik, Forschungszentrum Juelich Gmbh, Association EURATOM-FZJ, member of Trilateral Euregio Cluster, 52425 Juelich (Germany); Baross, T. [KFKI RMKI, EURATOM Association, PO Box 49, H-1521 Budapest (Hungary); Bourauel, P. [Institut fuer Energieforschung - Plasmaphysik, Forschungszentrum Juelich Gmbh, Association EURATOM-FZJ, member of Trilateral Euregio Cluster, 52425 Juelich (Germany); Dunai, D. [KFKI RMKI, EURATOM Association, PO Box 49, H-1521 Budapest (Hungary); Durkut, M. [TNO Science and Industry, Partner in ITER-NL, P.O. Box 155, 2600 AD Delft (Netherlands); Erdei, G. [BME, EURATOM Association, PO Box 91, H-1521 Budapest (Hungary); Hawkes, N. [Association EURATOM/CCFE, OX14 3DB Abingdon (United Kingdom); Hellermann, M. von [FOM-Institute for Plasma Physics Rijnhuizen, Association EURATOM-FOM, partner in the Trilateral Euregio Cluster and ITER-NL, P.O. Box 1207, 3430 BE Nieuwegein (Netherlands); Hogenbirk, A. [Nuclear Research and Consultancy Group V.o.F., Petten (Netherlands); Jaspers, R. [Department of Applied Physics, Eindhoven University of Technology (Netherlands); Kiss, G. [Institut fuer Energieforschung - Plasmaphysik, Forschungszentrum Juelich Gmbh, Association EURATOM-FZJ, member of Trilateral Euregio Cluster, 52425 Juelich (Germany); Klinkhamer, F. [TNO Science and Industry, Partner in ITER-NL, P.O. Box 155, 2600 AD Delft (Netherlands); Koning, J.F. [FOM-Institute for Plasma Physics Rijnhuizen, Association EURATOM-FOM, partner in the Trilateral Euregio Cluster and ITER-NL, P.O. Box 1207, 3430 BE Nieuwegein (Netherlands); Kotov, V.; Krasikov, Y.; Krimmer, A. [Institut fuer Energieforschung - Plasmaphysik, Forschungszentrum Juelich Gmbh, Association EURATOM-FZJ, member of Trilateral Euregio Cluster, 52425 Juelich (Germany)

    2011-10-15

    The ITER core charge exchange recombination spectroscopy (core CXRS) diagnostic system is designed to provide experimental access to various measurement quantities in the ITER core plasma such as ion densities, temperatures and velocities. The implementation of the approved CXRS diagnostic principle on ITER faces significant challenges: First, a comparatively low CXRS signal intensity is expected, together with a high noise level due to bremsstrahlung, while the requested measurement accuracy and stability for the core CXRS system go far beyond the level commonly achieved in present-day fusion experiments. Second, the lifetime of the first mirror surface is limited due to either erosion by fast particle bombardment or deposition of impurities. Finally, the hostile technical environment on ITER imposes challenging boundary conditions for the diagnostic integration and operation, including high neutron loads, electro-magnetic loads, seismic events and a limited access for maintenance. A brief overview on the R and D and design activities for the core CXRS system is presented here, while the details are described in parallel papers.

  15. Synchronous brain activity during cooperative exchange depends on gender of partner: A fNIRS-based hyperscanning study.

    Science.gov (United States)

    Cheng, Xiaojun; Li, Xianchun; Hu, Yi

    2015-06-01

    Previous studies have shown that brain activity between partners is synchronized during cooperative exchange. Whether this neural synchronization depends on the gender of partner (i.e., opposite or same to the participant) is open to be explored. In current study, we used functional near-infrared spectroscopy (fNIRS) based hyperscanning to study cooperation in a two-person game (female-female, female-male, and male-male) while assaying brain-to-brain interactions. Cooperation was greater in male-male pairs than in female-female pairs, with intermediate cooperation levels for female-male pairs. More importantly, in dyads with partners with opposite gender (female-male pairs), we found significant task-related cross-brain coherence in frontal regions (i.e., frontopolar cortex, orbitofrontal cortex, and left dorsolateral prefrontal cortex) whereas the cooperation in same gender dyads (female-female pairs and male-male pairs) was not associated with such synchronization. Moreover, the changes of such interbrain coherence across task blocks were significantly correlated with change in degree of cooperation only in mixed-sex dyads. These findings suggested that different neural processes underlie cooperation between mixed-sex and same-sex dyadic interactions. © 2015 Wiley Periodicals, Inc.

  16. Orientation of monoclonal antibodies in ion-exchange chromatography: A predictive quantitative structure-activity relationship modeling approach.

    Science.gov (United States)

    Kittelmann, Jörg; Lang, Katharina M H; Ottens, Marcel; Hubbuch, Jürgen

    2017-08-11

    Chromatographic separation of biopharmaceuticals in general and monoclonal antibodies (mAbs) specifically is the bottleneck in terms of cost and throughput in preparative purification. Still, generalized platform processes are used, neglecting molecule specific characteristics, defining protein-resin interaction terms. Currently used in silico modeling approaches do not consider the orientation of the molecule towards the chromatographic resins as a result of the structural features on an atomic level. This paper describes a quantitative structure-activity relationship (QSAR) approach to model the orientation of mAbs on ion exchange chromatographic matrices as a function of property distribution and mobile phase characteristics. 6 mAbs were used to build a predictive QSAR model and to investigate the preferred binding orientations and resulting surface shielding on resins. Thereby different dominating orientations, caused by composition of F ab fragments of the mAbs, could be identified. The presented methodology is suitable to gain extended insight in molecule orientation on chromatographic resins and to tailor purification strategies based on molecule structure. Copyright © 2017 Elsevier B.V. All rights reserved.

  17. Dissecting the effect of RNA aptamer binding on the dynamics of plasminogen activator inhibitor 1 using hydrogen/deuterium exchange mass spectrometry

    DEFF Research Database (Denmark)

    Trelle, Morten B; Dupont, Daniel Miotto; Madsen, Jeppe Buur

    2014-01-01

    , about their effects on protein conformation and dynamics. We have employed hydrogen/deuterium exchange (HDX) mass spectrometry to study the effect of RNA aptamers on the structural flexibility of the serpin plasminogen activator inhibitor-1 (PAI-1). The aptamers have characteristic effects...... of the aptamers to PAI-1 is associated with substantial and widespread protection against deuterium uptake in PAI-1. The aptamers induce protection against exchange with the solvent both in the protein-aptamer interface as well as in other specific areas. Interestingly, the aptamers induce substantial protection...... against exchange in α-helices B, C and I. This observation substantiates the relevance of structural instability in this region for transition to the latent state and argues for involvement of flexibility in regions not commonly associated with regulation of latency transition in serpins....

  18. The rapid and direct determination of ATPase activity by ion exchange chromatography and the application to the activity of heat shock protein-90.

    Science.gov (United States)

    Bartolini, Manuela; Wainer, Irving W; Bertucci, Carlo; Andrisano, Vincenza

    2013-01-25

    Adenosine nucleotides are involved as substrates or co-factors in several biochemical reactions, catalyzed by enzymes, which modulate energy production, signal transduction and cell proliferation. We here report the development and optimization of an ion exchange liquid chromatography (LC) method for the determination of ATP, ADP and AMP. This method is specifically aimed at the determination of the ATP-ase activity of human heat shock protein 90 (Hsp90), a molecular chaperone that has emerged as target enzyme in cancer therapy. Separation of the three nucleotides was achieved in a 15-min run by using a disk shaped monolithic ethylene diamine stationary phase of small dimensions (2mm×6mm i.d.), under a three-solvent gradient elution mode and UV detection at 256nm. The described direct LC method resulted highly specific as a consequence of the baseline separation of the three adenosine nucleotides and could be applied to the determination of the enzymatic activity of ADP/ATP generating or consuming enzymes (such as kinases). Furthermore, comparison of the LOD and LOQ values of the LC method with those obtained with the malachite green assay, which is one of the most used indirect screening methodologies for ATP-ase activity, showed that the LC method has a similar range of application without presenting the drawbacks related to contamination by inorganic phosphate ions and glycerol, which are present in Hsp90 commercial samples. Copyright © 2012 Elsevier B.V. All rights reserved.

  19. Activity theory as a potential framework for technology research in ...

    African Journals Online (AJOL)

    of the activity system leads to shifts at all levels of the system. I conclude by arguing that the strength of Activity Theory lies in its ability to enable one to understand learning as the complex result of tool mediated interactions, rather than as something opaque, which happens in a student's mind. South African Journal of ...

  20. Tracking Overhead ORTA Costs in Technology Transfer Activities

    National Research Council Canada - National Science Library

    Van

    1997-01-01

    ...) organizations and the activities performed within these organizations. It was hypothesized that the ORTA organizations, which are considered indirect labor by most costing methods, would expend considerable portions of their resources on activities identified as not being performed by direct labor. This hypothesis was proven true, as all but two of the identified steps consumed a significant portion of the ORTA resources.

  1. Catalytic activity of superconducting ceramics of Y-Ba-Cu-O type in reaction of H-D exchange of molecular hydrogen

    International Nuclear Information System (INIS)

    Parbuzin, V.S.; Gul'yants, V.V.

    1989-01-01

    Catalytic activity of high-temperature superconducting oxide ceramics of Y-Ba-Cu-O type in reaction of deuterium-hydrogen exchange was investigated under chromatographic conditions. Rate constants of the reaction and activation energy of the process, equal to 58 ± 2 kJ/mol, were determined in 350 - 450 K range and at 18250Pa hydrogen pressure. Assumption about applicability of Bonhoeffer-Farkas mechanism with adsorption on copper atoms, adjoinig oxygen vacancies, was made

  2. Cytotoxic mechanisms of Zn2+ and Cd2+ involve Na+/H+ exchanger (NHE) activation by ROS

    International Nuclear Information System (INIS)

    Koutsogiannaki, Sophia; Evangelinos, Nikolaos; Koliakos, George; Kaloyianni, Martha

    2006-01-01

    The signaling mechanism induced by cadmium (Cd) and zinc (Zn) in gill cells of Mytilus galloprovincialis was investigated. Both metals cause an increase in ·O 2 - production, with Cd to be more potent (216 ± 15%) than Zn (150 ± 9.5%), in relation to control value (100%). The metals effect was reversed after incubation with the amiloride analogue, EIPA, a selective Na + /H + exchanger (NHE) inhibitor as well as in the presence of calphostin C, a protein kinase C (PKC) inhibitor. The heavy metals effect on ·O 2 - production was mediated via the interaction of metal ions with α 1 - and β-adrenergic receptors, as shown after incubation with their respective agonists and antagonists. In addition, both metals caused an increase in intracellular pH (pHi) of gill cells. EIPA together with either metal significantly reduced the effect of each metal treatment on pHi. Incubation of gill cells with the oxidants rotenone, antimycin A and pyruvate caused a significant increase in pHi (ΔpHi 0.830, 0.272 and 0.610, respectively), while in the presence of the anti-oxidant N-acetyl cysteine (NAC) a decrease in pHi (ΔpHi -0.090) was measured, indicating that change in reactive oxygen species (ROS) production by heavy metals affects NHE activity. When rosiglitazone was incubated together with either heavy metal a decrease in O 2 - production was observed. Our results show a key role of NHE in the signal transduction pathway induced by Zn and Cd in gill cells, with the involvement of ROS, PKC, adrenergic and PPAR-γ receptors. In addition, differences between the two metals concerning NHE activation, O 2 - production and interaction with adrenergic receptors were observed

  3. Spin-off technologies developed through nuclear activities

    International Nuclear Information System (INIS)

    1993-01-01

    Given the changing role of government research establishments and the interest in maximizing return on capital and intellectual investment, determining the best way to apply or ''spin-off'' technologies from the nuclear field into other industrial and commercial sectors is of increasing concern. This study by the OECD Nuclear Energy Agency draws on expertise from numerous countries to determine what the spin-offs are, where they come from, and how they can best be fostered. It looks both at the results and process of spin-offs, and helps decision-makers in government and project leaders and managers in industry to maximize their benefits. (author)

  4. Activation of exchange protein activated by cAMP in the rat basolateral amygdala impairs reconsolidation of a memory associated with self-administered cocaine.

    Directory of Open Access Journals (Sweden)

    Xun Wan

    Full Text Available The intracellular mechanisms underlying memory reconsolidation critically involve cAMP signaling. These events were originally attributed to PKA activation by cAMP, but the identification of Exchange Protein Activated by cAMP (Epac, as a distinct mediator of cAMP signaling, suggests that cAMP-regulated processes that subserve memory reconsolidation are more complex. Here we investigated how activation of Epac with 8-pCPT-cAMP (8-CPT impacts reconsolidation of a memory that had been associated with cocaine self-administration. Rats were trained to lever press for cocaine on an FR-1 schedule, in which each cocaine delivery was paired with a tone+light cue. Lever pressing was then extinguished in the absence of cue presentations and cocaine delivery. Following the last day of extinction, rats were put in a novel context, in which the conditioned cue was presented to reactivate the cocaine-associated memory. Immediate bilateral infusions of 8-CPT into the basolateral amygdala (BLA following reactivation disrupted subsequent cue-induced reinstatement in a dose-dependent manner, and modestly reduced responding for conditioned reinforcement. When 8-CPT infusions were delayed for 3 hours after the cue reactivation session or were given after a cue extinction session, no effect on cue-induced reinstatement was observed. Co-administration of 8-CPT and the PKA activator 6-Bnz-cAMP (10 nmol/side rescued memory reconsolidation while 6-Bnz alone had no effect, suggesting an antagonizing interaction between the two cAMP signaling substrates. Taken together, these studies suggest that activation of Epac represents a parallel cAMP-dependent pathway that can inhibit reconsolidation of cocaine-cue memories and reduce the ability of the cue to produce reinstatement of cocaine-seeking behavior.

  5. International exchange project for the engineer exchange project (in coal mine technology area) in fiscal 1998. Pre-survey in Europe; 1998 nendo gijutsusha koryu jigyo (tanko gijutsu bun'ya) kokusai koryu jigyo. Jizen chosa (Oshu)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    This survey in Europe surveyed the current status of the coal industry, supporting directions and policies of governments on the coal industry, and summarized the information thereof. The survey included movements in policies and activities in transfer of technologies to overseas countries by governments and corporations of different countries, and the current status of the coal technology training project. The survey covered Britain and Germany. The British coal industry is facing a serious difficulty because the electric power industry being the major coal purchaser has changes its sourcing to natural gas. In addition, the open-cut mining which has been considered high in productivity has no further hope of big progress due to regulations in the environmental aspects. However, as a result of having performed positively research and development on production cost reduction, the production efficiency has grown excellently. Using this situation as the base, positive advancement into overseas countries is being carried out. The German coal industry has, in spite of having reduced the production size and the number of coal mines, shifted coal purchasers to electric power generation and steel making areas, and its quality and supply capability stand equivalent to those of imported coals. (NEDO)

  6. Technological Activities and Their Impact on the Financial Performance of the Firm : Exploitation and Exploration within and between Firms

    NARCIS (Netherlands)

    Belderbos, Rene; Faems, Dries; Leten, Bart; Van Looy, Bart

    2010-01-01

    The present study analyzes the impact of firms' technological strategies on their financial performance. Technology strategies are defined by making a distinction between explorative and exploitative as well as collaborative and solitary technological activities. Several hypotheses are tested on a

  7. USE OF INFORMATION TECHNOLOGIES IN EDUCATIONAL EXTRACURRICULAR ACTIVITIES IN HIGHER TOURIST INSTITUTIONS

    Directory of Open Access Journals (Sweden)

    Yuliia O. Matviyiv-Lozynska

    2013-04-01

    Full Text Available The article deals with extracurricular educational activities in higher educational establishment of tourism profile with information technologies usage. It is known that extracurricular activities of higher educational establishment has an impact on the professional activities of future specialists in the tourism industry, as is in the process of extracurricular activities students can put into practice the obtained knowledge and skills. The task of teachers is to build a learning process, in particular activities outside classrooms as its component, so that the students were interested in it. In the modern world of tourism prosperity it is very difficult to do without the usage of multimedia technologies (internet, media, etc.

  8. Shaping old age: Innovation partnerships, senior centres and billiards tables as active ageing technologies

    DEFF Research Database (Denmark)

    Lassen, Aske Juul

    2017-01-01

    explores the ways that active ageing policies become part of everyday practices, by proposing the concept of active ageing technologies. Active ageing technologies are material and immaterial condensations of knowledge that form old age in specific ways. Through the cases of an innovation partnership, two......During the past decade active ageing has been positioned as a solution to the problem of global ageing. While the scientific, economic and even moral arguments for pursuing a more active old age has been many, the integration of active ageing in everyday practices face challenges. This chapter...... activity centres and a billiards table, the author explores how active ageing policies are transformed in practice. The chapter draws on an ethnographic study of active ageing conducted at the two activity centres, as well as the author’s participation in the innovation partnership. The author uses...

  9. Shaping old age: Innovation partnerships, senior centres and billiards tables as active ageing technologies

    DEFF Research Database (Denmark)

    Lassen, Aske Juul

    2017-01-01

    During the past decade active ageing has been positioned as a solution to the problem of global ageing. While the scientific, economic and even moral arguments for pursuing a more active old age has been many, the integration of active ageing in everyday practices face challenges. This chapter...... explores the ways that active ageing policies become part of everyday practices, by proposing the concept of active ageing technologies. Active ageing technologies are material and immaterial condensations of knowledge that form old age in specific ways. Through the cases of an innovation partnership, two...... activity centres and a billiards table, the author explores how active ageing policies are transformed in practice. The chapter draws on an ethnographic study of active ageing conducted at the two activity centres, as well as the author’s participation in the innovation partnership. The author uses...

  10. Recent progress in accelerator activities at Raja Ramanna Centre for Advanced Technology, Indore

    International Nuclear Information System (INIS)

    Gupta, P.D.

    2013-01-01

    Raja Ramanna Centre for Advanced Technology, Indore is a premier national institute engaged in R and D work in front-line areas of accelerator science, technology, and applications. The Centre has designed, developed, and commissioned two synchrotron radiation sources: Indus-1 and Indus-2, serving as national facilities. The Centre is pursuing various other accelerator activities viz. development of a high energy proton accelerator for a spallation neutron source, electron accelerators for food irradiation and industrial applications and free electron lasers (FEL) in THz and IR spectral region, study of innovative schemes of laser driven electron acceleration, and development of advanced technologies to support these activities such as superconducting RF (SCRF) technology, cryogenics, RF power, magnets, ultra high vacuum and control instrumentation. In this talk, an overview of the progress made in accelerator activities at Raja Ramanna Centre for Advanced Technology in recent years is be presented

  11. ECUT: Energy Conversion and Utilization Technologies program - Biocatalysis research activity

    Science.gov (United States)

    Wilcox, R.

    1984-01-01

    The activities of the Biocatalysis Research Activity are organized into the Biocatalysis and Molecular Modeling work elements and a supporting planning and analysis function. In the Biocatalysis work element, progress is made in developing a method for stabilizing genetically engineered traits in microorganisms, refining a technique for monitoring cells that are genetically engineered, and identifying strains of fungi for highly efficient preprocessing of biomass for optimizing the efficiency of bioreactors. In the Molecular Modeling work element, a preliminary model of the behavior of enzymes is developed. A preliminary investigation of the potential for synthesizing enzymes for use in electrochemical processes is completed. Contact with industry and universities is made to define key biocatalysis technical issues and to broaden the range of potential participants in the activity. Analyses are conducted to identify and evaluate potential concepts for future research funding.

  12. Active Dust Mitigation Technology for Thermal Radiators for Lunar Exploration

    Science.gov (United States)

    Calle, C. I.; Buhler, C. R.; Hogue, M. D.; Johansen, M. R.; Hopkins, J. W.; Holloway, N. M. H.; Connell, J. W.; Chen, A.; Irwin, S. A.; Case, S. O.; hide

    2010-01-01

    Dust accumulation on thermal radiator surfaces planned for lunar exploration will significantly reduce their efficiency. Evidence from the Apollo missions shows that an insulating layer of dust accumulated on radiator surfaces could not be removed and caused serious thermal control problems. Temperatures measured at different locations in the magnetometer on Apollo 12 were 38 C warmer than expected due to lunar dust accumulation. In this paper, we report on the application of the Electrodynamic Dust Shield (EDS) technology being developed in our NASA laboratory and applied to thermal radiator surfaces. The EDS uses electrostatic and dielectrophoretic forces generated by a grid of electrodes running a 2 micro A electric current to remove dust particles from surfaces. Working prototypes of EDS systems on solar panels and on thermal radiators have been successfully developed and tested at vacuum with clearing efficiencies above 92%. For this work EDS prototypes on flexible and rigid thermal radiators were developed and tested at vacuum.

  13. Alpha contamination assessment for D ampersand D activities: Technology overview

    International Nuclear Information System (INIS)

    Conaway, J.G.; Rawool-Sullivan, M.W.; MacArthur, D.W.

    1996-02-01

    Instruments based on the principle of Long-Range Alpha Detection (LRAD) detect the ions created in ambient air by Ionizing radiation, particularly alpha radiation, interacting with air molecules. Using either an electrostatic field or forced convection, these ions can be transported to a detection grid where the ions produce a small current that is measured with a sensitive electrometer. LRAD-based instruments can give separate, simultaneous measurements of alpha-emitting solids and inert radioactive gases such as radon. LRAD-based instruments assess surface contamination on an entire object or large surface area in a single, rapid measurement, including relatively inaccessible areas such as interior surfaces of pipes and process equipment. The LRAD concept is well proven and has been developed into a range of different radiation detection devices. This paper presents an overview of the technology, while several associated papers explore specific applications in greater detail

  14. [MEDICAL SOCIAL MODELING TECHNOLOGIES FOR ACTIVE AGING IN KAZAKHSTAN].

    Science.gov (United States)

    Benberin, V V; Akhetov, A A; Tanbaeva, G Z

    2015-01-01

    The article discusses a new model for active ageing in Republic of Kazakhstan with participation the state, population and medical social services. Achieving active longevity will lead to positive trends in the development of human capital of the state, because it enables to use experience and knowledge of senior generation in enhancing the effectiveness of socio-economic transformation in health care. The study was carried out on the base of the Central clinical hospital of the President's affairs administration in Republic of Kazakhstan, with the participation of 147 admitted patients of elderly and senile age.

  15. Radar activities of the DFVLR Institute for Radio Frequency Technology

    Science.gov (United States)

    Keydel, W.

    1983-01-01

    Aerospace research and the respective applications microwave tasks with respect to remote sensing, position finding and communication are discussed. The radar activities are directed at point targets, area targets and volume targets; they center around signature research for earth and ocean remote sensing, target recognition, reconnaissance and camouflage and imaging and area observation radar techniques (SAR and SLAR). The radar activities cover a frequency range from 1 GHz up to 94 GHz. The radar program is oriented to four possible application levels: ground, air, shuttle orbits and satellite orbits. Ground based studies and measurements, airborne scatterometers and imaging radars, a space shuttle radar, the MRSE, and follow on experiments are considered.

  16. Cellulose Electro-Active Paper: From Discovery to Technology Applications

    Directory of Open Access Journals (Sweden)

    Zafar eAbas

    2014-09-01

    Full Text Available Cellulose electro-active paper (EAPap is an attractive material of electro-active polymers (EAPs family due to its smart characteristics. EAPap is thin cellulose film coated with metal electrodes on both sides. Its large displacement output, low actuation voltage and low power consumption can be used for biomimetic sensors/actuators and electromechanical system. Because cellulose EAPap is ultra-lightweight, easy to manufacture, inexpensive, biocompatible, and biodegradable, it has been employed for many applications such as bending actuator, vibration sensor, artificial muscle, flexible speaker, and can be advantageous in areas such as micro-insect robots, micro-flying objects, microelectromechanical systems, biosensors, and flexible displays.

  17. The behavioral outcomes of a technology-supported leisure activity in people with dementia

    NARCIS (Netherlands)

    J.E.W.C. Gemert-Pijnen; N. Nijhof; Joost van Hoof; H. van Rijn

    2013-01-01

    BACKGROUND: This paper presents the results of an evaluation of a technology-supported leisure game for people with dementia in relation to the stimulation of social behavior. OBJECTIVE: In this study we explore the additional impact of technology-supported leisure activities on behavioral outcomes

  18. CAST STONE TECHNOLOGY FOR THE TREATMENT AND IMMOBILIZATION OF LOW-ACTIVITY WASTE

    Energy Technology Data Exchange (ETDEWEB)

    MINWALL HJ

    2011-04-08

    Cast stone technology is being evaluated for potential application in the treatment and immobilization of Hanford low-activity waste. The purpose of this document is to provide background information on cast stone technology. The information provided in the report is mainly based on a pre-conceptual design completed in 2003.

  19. Promoting Active Learning in Technology-Infused TILE Classrooms at the University of Iowa

    Science.gov (United States)

    Van Horne, Sam; Murniati, Cecilia; Gaffney, Jon D. H.; Jesse, Maggie

    2012-01-01

    In this case study, the authors describe the successful implementation of technology-infused TILE classrooms at the University of Iowa. A successful collaboration among campus units devoted to instructional technologies and teacher development, the TILE Initiative has provided instructors with a new set of tools to support active learning. The…

  20. Synthesizing Technology Adoption and Learners' Approaches towards Active Learning in Higher Education

    Science.gov (United States)

    Chan, Kevin; Cheung, George; Wan, Kelvin; Brown, Ian; Luk, Green

    2015-01-01

    In understanding how active and blended learning approaches with learning technologies engagement in undergraduate education, current research models tend to undermine the effect of learners' variations, particularly regarding their styles and approaches to learning, on intention and use of learning technologies. This study contributes to further…

  1. 75 FR 33631 - Science and Technology (S&T) Directorate; Agency Information Collection Activities: Submission...

    Science.gov (United States)

    2010-06-14

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2010-0040] Science and Technology (S&T) Directorate; Agency Information Collection Activities: Submission for Review; Information Collection Request for the Department of Homeland Security (DHS) Science and Technology TechSolutions Program AGENCY...

  2. The Potential of Using Virtual Reality Technology in Physical Activity Settings

    Science.gov (United States)

    Pasco, Denis

    2013-01-01

    In recent years, virtual reality technology has been successfully used for learning purposes. The purposes of the article are to examine current research on the role of virtual reality in physical activity settings and discuss potential application of using virtual reality technology to enhance learning in physical education. The article starts…

  3. Emplotment, Embodiment, Engagement: Narrative Technology in Support of Physical Education, Sport and Physical Activity

    Science.gov (United States)

    Hall, Tony

    2012-01-01

    This paper is based on a keynote lecture delivered at the International Association of Physical Education in Higher Education 2011 Conference, University of Limerick, on the sub theme: "Technologies in Support of Physical Education, Sport, and Physical Activity." The paper outlines and illustrates a framework: narrative technology, which can be…

  4. Exploring the Use of Technology for Active Aging and Thriving.

    Science.gov (United States)

    Øderud, Tone; Østensen, Elisabeth; Gjevjon, Edith Roth; Moen, Anne

    2017-01-01

    The study explores how older adults with limited digital experience become users of tablet computers (iPad) with Internet access, and how the tablet computers become part of their daily life facilitating active aging and thriving. Volunteer adolescents were mobilised to teach and follow up the participants regularly.

  5. Use of cellphone technology in activity and travel data collection

    CSIR Research Space (South Africa)

    Krygsman, S

    2006-02-01

    Full Text Available Data needs of developing countries, particularly in terms of activity and travel data collection, are explored in this poster. This proof-of-concept study revealed that it is indeed possible to obtain detailed individual travel behaviour data from...

  6. Pro-active Management of Traffic Incidents Using Novel Technologies

    NARCIS (Netherlands)

    Nitsche, P.; Olstam, J.; Taylor, N.; Reinthaler, M.; Ponweiser, W.; Bernhardsson, V.; Mocanu, I.; Uittenbogaard, J.; Dam, E. van

    2016-01-01

    This paper presents the results of the assessment phase of the project PRIMA (Pro-Active Incident Management), where the benefits, costs and risks of novel traffic incident management techniques are investigated. The project targets the enhancement of current state-of-the-art measures for handling

  7. Using Technology to Increase Physical Activity in Health Profession Students

    Directory of Open Access Journals (Sweden)

    Mary Ann Stark

    2016-01-01

    Full Text Available Health profession students may need help establishing and maintaining positive health behaviors when they are in college. This study explored the effectiveness of text messaging as an innovative method for promoting an increase in daily physical activity. A convenience sample (N = 134 was recruited from students at a college of Health and Human Services in Michigan. The participants were randomized into an intervention or control group (n = 67 each. The intervention group received daily affective text messages encouraging more physical activity by taking more steps. The control group received only messages reminding them to report their number of steps. All of the participants received a pedometer, completed a demographics and daily habits questionnaire, and completed the Perceived Stress Scale (PSS. There was no significant difference between the intervention and control groups in their number of daily steps. However, the most inactive participants had a significant increase in steps during the study period. Health profession students’ lifestyle behaviors have consequences, as they become caregivers in our dynamic, demanding health-care system. For those with the greatest need for physical activity, encouraging such activity via text messaging may improve their ability to care for themselves and their clients.

  8. Route activity tracking and management using available technology

    Directory of Open Access Journals (Sweden)

    Sam Yousef Khoury

    2012-01-01

    Full Text Available Small organizations that maintain their own fleet and make their own deliveries are responsible for ensuring their drivers are utilizing the most efficient routes while delivering products to their customers. Furthermore, efficient delivery requires that drivers spend as little time as possible dropping off and picking up products, since these activities are referred to as “non-value added activities,” although they are necessary tasks in the order cycle process. To aid in reducing order cycle times, large organizations that can afford it have employed transportation management systems. Unfortunately, small organizations with limited resources are less likely to adopt transportation management systems, despite the need for such automation. One solution is to use available productivity software to track and manage driver route activity in an effort to improve and maintain driver productivity by reducing non-value time and identifying optimal routes. This paper will outline how office productivity software such as Microsoft® Access can meet the needs of small organizations with limited resources by describing the development and use of a route activity database that employs an easy-to-use multi-user interface. This paper also includes the details of the underlying infrastructure and the user interface.

  9. Physical activity and situational interest in mobile technology integrated physical education: A preliminary study

    Directory of Open Access Journals (Sweden)

    Xihe Zhu

    2016-06-01

    Full Text Available Background: Mobile technology permeates every aspect of student lives. The question is whether mobile technology integration can produce desirable effects in the gymnasium. Objective: This preliminary study aimed to investigate the effects of mobile technology integration on student situational interest and physical activity fluctuation in physical education lessons.Methods: Sixth grade students (N = 53 were randomly placed into either an experiment group by class that utilized mobile technology-integrated resources (iPad and applications, or a comparison group that did not utilize technology. Both groups received five identical physical education lessons. Student physical activity was tracked with accelerometers, and they completed the Situational Interest Scale at the end of each lesson. The researchers analyzed the data using descriptive statistics, correlation analysis and multivariate analysis of variance (MANOVA with repeated measures. Results: Students in the experiment group reported significantly lower physical activity and situational interest than their counterparts in the comparison group. A group × lesson interaction suggested that student step/min steadily increased throughout the lessons in the experiment group while remaining relative stable in the comparison group. Conclusions: Mobile technologies such as iPad and applications with no direct physical activity prompt had little effect on increasing physical activity or situational interest in the short term. It is important to consider the classroom dynamics to realistically evaluate the constraints and strengths that mobile technology-integrated physical education lessons may pose in a traditional physical education environment.

  10. Active Control Technology for Enhanced Performance Operational Capabilities of Military Aircraft, Land Vehicles and Sea Vehicles (Technologies des systemes a commandes actives pour l'amelioration des performances operationnelles des aeronefs militaires, des vehicules terrestres et des vehicules maritimes)

    National Research Council Canada - National Science Library

    2001-01-01

    ... Technology For Load Alleviation, Active Elements for Structural Design, Active Materials and Applications, Applications Overview, Compressor Stall/ Surge - Measurements, Compressor Stall/Surge - Control...

  11. Situation awareness of active distribution network: roadmap, technologies, and bottlenecks

    DEFF Research Database (Denmark)

    Lin, Jin; Wan, Can; Song, Yonghua

    2016-01-01

    With the rapid development of local generation and demand response, the active distribution network (ADN), which aggregates and manages miscellaneous distributed resources, has moved from theory to practice. Secure and optimal operations now require an advanced situation awareness (SA) system so...... in the project of developing an SA system as the basic component of a practical active distribution management system (ADMS) deployed in Beijing, China, is presented. This paper reviews the ADN’s development roadmap by illustrating the changes that are made in elements, topology, structure, and control scheme....... Taking into consideration these hardware changes, a systematic framework is proposed for the main components and the functional hierarchy of an SA system for the ADN. The SA system’s implementation bottlenecks are also presented, including, but not limited to issues in big data platform, distribution...

  12. The Spanish CEIDEN Technology Platform: Activities on Knowledge Management

    International Nuclear Information System (INIS)

    Velasco, R.; Montero, A.; Ruiz, F.; Leon, P.

    2016-01-01

    Full text: CEIDEN is a Spanish organization for the coordination of the needs and efforts on nuclear fission research and development (R&D). It was created in 1999 and since 2007 has the status of technology platform. The main functions of CEIDEN are to define and develop joint R&D projects, and to present a common position for national and international commitments and proposals in the nuclear fission R&D field. With around one hundred of Spanish members and a significant number of foreign collaborative entities, CEIDEN groups all sectors involved in this field. In 2011 the CEIDEN F+ permanent group was created to cope with the E&T issues. The main objectives of F+ are to promote the coordination of E&T programmes in a national level and to support the Spanish participation in international networks, programmes and projects in this field. Knowledge management is more and more a paramount issue that conditions the future of the Spanish nuclear sector, especially all the related to the generational replacement. In response to this challenge, a nuclear knowledge management group has been created recently in CEIDEN with the target of start coordinated initiatives in the Spanish nuclear sector, in this field. (author

  13. Heat exchanger

    International Nuclear Information System (INIS)

    Leigh, D.G.

    1976-01-01

    The arrangement described relates particularly to heat exchangers for use in fast reactor power plants, in which heat is extracted from the reactor core by primary liquid metal coolant and is then transferred to secondary liquid metal coolant by means of intermediate heat exchangers. One of the main requirements of such a system, if used in a pool type fast reactor, is that the pressure drop on the primary coolant side must be kept to a minimum consistent with the maintenance of a limited dynamic head in the pool vessel. The intermediate heat exchanger must also be compact enough to be accommodated in the reactor vessel, and the heat exchanger tubes must be available for inspection and the detection and plugging of leaks. If, however, the heat exchanger is located outside the reactor vessel, as in the case of a loop system reactor, a higher pressure drop on the primary coolant side is acceptable, and space restriction is less severe. An object of the arrangement described is to provide a method of heat exchange and a heat exchanger to meet these problems. A further object is to provide a method that ensures that excessive temperature variations are not imposed on welded tube joints by sudden changes in the primary coolant flow path. Full constructional details are given. (U.K.)

  14. Activation of protein kinase A and exchange protein directly activated by cAMP promotes adipocyte differentiation of human mesenchymal stem cells.

    Directory of Open Access Journals (Sweden)

    Bingbing Jia

    Full Text Available Human mesenchymal stem cells are primary multipotent cells capable of differentiating into several cell types including adipocytes when cultured under defined in vitro conditions. In the present study we investigated the role of cAMP signaling and its downstream effectors, protein kinase A (PKA and exchange protein directly activated by cAMP (Epac in adipocyte conversion of human mesenchymal stem cells derived from adipose tissue (hMADS. We show that cAMP signaling involving the simultaneous activation of both PKA- and Epac-dependent signaling is critical for this process even in the presence of the strong adipogenic inducers insulin, dexamethasone, and rosiglitazone, thereby clearly distinguishing the hMADS cells from murine preadipocytes cell lines, where rosiglitazone together with dexamethasone and insulin strongly promotes adipocyte differentiation. We further show that prostaglandin I(2 (PGI(2 may fully substitute for the cAMP-elevating agent isobutylmethylxanthine (IBMX. Moreover, selective activation of Epac-dependent signaling promoted adipocyte differentiation when the Rho-associated kinase (ROCK was inhibited. Unlike the case for murine preadipocytes cell lines, long-chain fatty acids, like arachidonic acid, did not promote adipocyte differentiation of hMADS cells in the absence of a PPARγ agonist. However, prolonged treatment with the synthetic PPARδ agonist L165041 promoted adipocyte differentiation of hMADS cells in the presence of IBMX. Taken together our results emphasize the need for cAMP signaling in concert with treatment with a PPARγ or PPARδ agonist to secure efficient adipocyte differentiation of human hMADS mesenchymal stem cells.

  15. Promoting Active Learning in Technology-Infused TILE Classrooms at the University of Iowa

    Directory of Open Access Journals (Sweden)

    Sam Van Horne

    2012-06-01

    Full Text Available In this case study, the authors describe the successful implementation of technology-infused TILE classrooms at the University of Iowa. A successful collaboration among campus units devoted to instructional technologies and teacher development, the TILE Initiative has provided instructors with a new set of tools to support active learning. The authors detail the implementation of the TILE classrooms, the process of training instructors to design effective instruction for these classrooms, and an assessment project that helps improve the process of ensuring faculty can successfully facilitate learning activities in a technology-infused learning environment.

  16. Guanine nucleotide exchange factor αPIX leads to activation of the Rac 1 GTPase/glycogen phosphorylase pathway in interleukin (IL)-2-stimulated T cells

    DEFF Research Database (Denmark)

    Llavero, Francisco; Urzelai, Bakarne; Osinalde, Nerea

    2015-01-01

    Recently, we have reported that the active form of Rac 1 GTPase binds to the glycogen phosphorylase muscle isoform (PYGM) and modulates its enzymatic activity leading to T cell proliferation. In the lymphoid system, Rac 1 and in general other small GTPases of the Rho family participate...... in the signaling cascades that are activated after engagement of the T cell antigen receptor. However, little is known about the IL-2-dependent Rac 1 activator molecules. For the first time, a signaling pathway leading to the activation of Rac 1/PYGM in response to IL-2-stimulated T cell proliferation is described....... More specifically, αPIX, a known guanine nucleotide exchange factor for the small GTPases of the Rho family, preferentially Rac 1, mediates PYGM activation in Kit 225 T cells stimulated with IL-2. Using directed mutagenesis, phosphorylation of αPIX Rho-GEF serines 225 and 488 is required for activation...

  17. Nuclear technology for sustainable development and FNCA activities

    International Nuclear Information System (INIS)

    Machi, Sueo

    2004-01-01

    Nuclear techniques have been contributing to sustainable development and human welfare through their applications in agriculture, health care, food supply, industry, water resources and environmental conservation. Nuclear techniques are more advantageous and/or complementary with other techniques to achieve goals. For many applications nuclear technique is more environmentally friendly because it does not need chemical agents to induce necessary reactions. This paper also illustrates successful applications of nuclear techniques and activities of the regional nuclear cooperation in Asia, FNCA (Forum for Nuclear Cooperation in Asia) to achieve common goals with limited resources. (author)

  18. NASA Activities as they Relate to Microwave Technology for Aerospace Communications Systems

    Science.gov (United States)

    Miranda, Felix A.

    2011-01-01

    This presentation discusses current NASA activities and plans as they relate to microwave technology for aerospace communications. The presentations discusses some examples of the aforementioned technology within the context of the existing and future communications architectures and technology development roadmaps. Examples of the evolution of key technology from idea to deployment are provided as well as the challenges that lay ahead regarding advancing microwave technology to ensure that future NASA missions are not constrained by lack of communication or navigation capabilities. The presentation closes with some examples of emerging ongoing opportunities for establishing collaborative efforts between NASA, Industry, and Academia to encourage the development, demonstration and insertion of communications technology in pertinent aerospace systems.

  19. Report on our activities to spread knowledge about radiation in Musashi Institute of Technology

    International Nuclear Information System (INIS)

    Okada, Yukiko

    2007-01-01

    In Musashi Institute of Technology, radiation knowledge spread activities are performed twice per year. One is 'the science experience classroom which children enjoy.' Another is 'the open school which studies atomic power'. The writer participated in the 'life and radiation' project as a WEN member, and has performed the radiation knowledge spread activities to a citizen. In this paper, these activities are introduced and the necessity and problem of radiation knowledge spread activities are considered. (author)

  20. Kidney Rehabilitation Technology by Improving Blood Flow and Nerve Activation

    International Nuclear Information System (INIS)

    Mohd Jamil Hashim

    2016-01-01

    The rehabilitation of kidney is impossible from doctors point of view. Kidney failure happens when nephron in kidney fail to filter blood and water. Two major causes of kidney failure. First is the shrinkage of kidney and the second is the blockage of kidney medulla. Kidney shrinkage is because nephron damage due to long term diabetes (Nephrology expert point of view). Whereas blockage of kidney is due to food consume which in turn build up deposit at the blood duct connecting to the medulla. Experiment specimen own body. The rehabilitation methodology is to build up your blood flow system and nerve activation. Result from the study is through analyzing blood components such as creatinine, hemoglobin, urea and potassium. Conclusion, creatinine value has lowered and kidney shrinkage has normalize to its original size. It is hopeful I regain my health 100 % when my GFR reading achieved below 100. (author)

  1. Evaluation of antiseptic disinfectant activity with static light scattering technology

    Directory of Open Access Journals (Sweden)

    Gaia Ortalli

    2017-12-01

    Full Text Available Background and aims. Healthcare-associated infections (HAI are an increasingly important issue, for this reason disinfection and antisepsis practices acquire importance. The use of products with antiseptic activity and reports of resistance to these molecules, pose the need to test, in the local area, the sensitivity pattern. The aim of this study is to verify the ability of the analytical system Alfred 60AST (Alifax Spa Isola dell’Abbà, Polverara - PD - Italy in evaluating the antimicrobial effectiveness in vitro of different molecules in comparison to the membrane filtration reference method, in accordance with the procedure NF T72- 152 proposed by the Association Française de Normalisation (AFNOR. Materials and Methods. We used four antiseptic-disinfectant substances, commonly used in hospital practic: Iodopovidone, Ethanol, Chlorhexidine and DECS. ATCC strains were assessed both with clinical isolates. The eventual development occurs by means of microbial ALFRED AST60 was carried out in progressive times (30, 60 and 120 minutes with different dilutions for each of the disinfectant molecules tested. Results and Conclusions. Comparison tests carried out between membrane filtration method and instrumentation Alfred 60AST gave results almost totally concordant. The analyzer Alfred 60AST can then be appropriately adapted to the in vitro evaluation of antiseptics, representing a valuable aid in the periodic monitoring of their activities and the prior assessment of sensitivity for therapeutic use. Though preliminary, the study confirms the existence of bacteria resistant to alcohols and biguanides, and it emphasizes the opportunity to verify the in vitro sensitivity profile.

  2. HEAT EXCHANGER

    Science.gov (United States)

    Fox, T.H. III; Richey, T. Jr.; Winders, G.R.

    1962-10-23

    A heat exchanger is designed for use in the transfer of heat between a radioactive fiuid and a non-radioactive fiuid. The exchanger employs a removable section containing the non-hazardous fluid extending into the section designed to contain the radioactive fluid. The removable section is provided with a construction to cancel out thermal stresses. The stationary section is pressurized to prevent leakage of the radioactive fiuid and to maintain a safe, desirable level for this fiuid. (AEC)

  3. Heat exchanger

    International Nuclear Information System (INIS)

    Watabe, Ichiro.

    1996-01-01

    An inner cylinder is disposed coaxially in a vertical vessel, and a plurality of heat transfer pipes are wound spirally on the outer circumference of the inner cylinder. High temperature sodium descends on the outer side of the inner cylinder while exchanging heat with water in the heat transfer pipes and becomes low temperature sodium. The low temperature sodium turns at the lower portion of the vessel, rises in a sodium exit pipe inserted to the inner cylinder and is discharged from the top of the vessel to the outside of the vessel. A portion of a cover gas (an inert gas such as argon) filled to the upper portion of the vessel intrudes into the space between the outer circumference of the sodium exit pipe and the inner circumference of the inner cylinder to form a heat insulation layer of the inert gas. This prevents heat exchange between the high temperature sodium before heat exchange and low temperature sodium after heat exchange. The heat exchanger is used as a secondary heat exchanger for coolants (sodium) of an FBR type reactor. (I.N.)

  4. Diurnal and seasonal variation in air exchange rates and interzonal airflows measured by active and passive tracer gas in homes

    DEFF Research Database (Denmark)

    Bekö, Gabriel; Gustavsen, Sine; Frederiksen, Marie

    2016-01-01

    Outdoor air delivery to buildings is an important parameter in the assessment of pollutant exposure indoors. Detailed and well controlled measurements of air exchange rates (AER) and interzonal airflows in residential environment are scarce. We measured the outdoor AERs in up to six rooms in five...

  5. Overview on R&D and design activities for the ITER core charge exchange spectroscopy diagnostic system

    NARCIS (Netherlands)

    Biel, W.; Baross, T.; Bourauel, P.; Dunai, D.; Durkut, M.; Erdei, G.; Hawkes, N.; Hellermann, M. von; Hogenbirk, A.; Jaspers, R.; Kiss, G.; Klinkhamer, J.F.F.; Koning, J.F.; Kotov, V.; Krasikov, Y.; Krimmer, A.; Lischtschenko, O.; Litnovsky, A.; Marchuk, O.; Neubauer, O.; Offermanns, G.; Panin, A.; Patel, K.; Pokol, G.; Schrader, M.; Snijders, B.; Szabo, V.; Valk, N.J.C. van der; Voinchet, R.; Wolters, J.; Zoletnik, S.

    2011-01-01

    The ITER core charge exchange recombination spectroscopy (core CXRS) diagnostic system is designed to provide experimental access to various measurement quantities in the ITER core plasma such as ion densities, temperatures and velocities. The implementation of the approved CXRS diagnostic principle

  6. Intergenerational Exchange of Knowledge, Skills, Values and Practices between Self-Organized Active Citizens in Maribor, Slovenia

    Science.gov (United States)

    Krašovec, Sabina Jelenc; Gregorcic, Marta

    2017-01-01

    Our paper deals with intergenerational informal learning developed by participatory democracy process in the Self-organized District Communities (SDC) in Maribor, the second largest city in Slovenia. It is based on the assumption that SDC assemblies, being safe and trustworthy, are very powerful spaces for behavioural and values exchange between…

  7. Radiosynthesis of [18F]fluorophenyl-L-amino acids by isotopic exchange on carbonyl-activated precursors

    International Nuclear Information System (INIS)

    Castillo Melean, Johnny

    2011-01-01

    Aromatic [ 18 F]fluoroamino acids have earlier been developed as promising probes for diagnostics using PET. However, a wider use of these radiofluorinated compounds has been limited due to radiosynthetic constraints. The work here presents an amenable three-step radiosynthesis pathway for the preparation of 2-[ 18 F]fluoro-L-phenylalanine (2-[ 18 F]Fphe), 2-[ 18 F]fluoro-L-tyrosine (2-[ 18 F]Ftyr), 6-[ 18 F]fuoro-L-m-tyrosine (6-[ 18 F]Fmtyr) and 6-[ 18 F]fluoro-L-DOPA (6-[ 18 F]FDOPA). For this, corresponding precursors were 18 F-fluorinated by nucleophilic isotopic exchange, followed by either removal of an activating formyl group with Rh(PPh 3 ) 3 Cl or its conversion by Baeyer-Villiger oxidation, respectively, and subsequent hydrolysis of protecting groups in acidic medium. Two efficient synthetic approaches were developed for the preparation of highly functionalized fluoro-benzaldehydes and -ketones which were used as labeling precursors. The compounds (2S,5S)-tert-butyl 2-tert-butyl-5-(2-fluoro-5-formylbenzyl)-3-methyl-4-oxoimidazolidine-1 -carboxylate (1a), (2S,5S)-tert-butyl 5-(5-acetyl-2-fluorobenzyl)-2-tert-butyl-3-methyl-4-oxoimidazolidine-1 -carboxylate (1c), (2S,5S)-benzyl 2-tert-butyl-5-(2-fluoro-5-formylbenzyl)-3-methyl-4-oxoimidazolidine-1 -carbo-xylate (1d), 4-fluoro-3-(((2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl) me-thyl)b enzal-dehyde (1e) and 1-(4-fluoro-3-(((2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl) me-thy l)phenyl)ethanone (1f), could be prepared in six steps and overall yields of 41%, 48%, 37%, 27%, and 32%, respectively. (2S,5S)-tert-Butyl 5-(4-(benzyloxy)-2-fluoro-5-formylbenzyl)-2-tert-butyl-3-methyl-4 -oxoimidazolidi ne-1-carboxylate (1b) was prepared in ten steps with an overall yield of 19% while compounds (2S,5S)-tert-butyl 5-(5-(3,5-bis(trifluoromethyl)-benzoyl)-2-fluorobenzyl)-2-tert-butyl-3 -methyl-4-oxoimidazolidine-1-carboxylate (1g) and (2S,5S)-tert-butyl 2-tert-butyl-5-(2-fluoro-5

  8. Oil and gas technology transfer activities and potential in eight major producing states. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    1993-07-01

    In 1990, the Interstate Oil and Gas Compact Commission (the Compact) performed a study that identified the structure and deficiencies of the system by which oil and gas producers receive information about the potential of new technologies and communicate their problems and technology needs back to the research community. The conclusions of that work were that major integrated companies have significantly more and better sources of technology information than independent producers. The majors also have significantly better mechanisms for communicating problems to the research and development (R&D) community. As a consequence, the Compact recommended analyzing potential mechanisms to improve technology transfer channels for independents and to accelerate independents acceptance and use of existing and emerging technologies. Building on this work, the Compact, with a grant from the US Department Energy, has reviewed specific technology transfer organizations in each of eight major oil producing states to identify specific R&D and technology transfer organizations, characterize their existing activities, and identify potential future activities that could be performed to enhance technology transfer to oil and gas producers. The profiles were developed based on information received from organizations,follow-up interviews, site visit and conversations, and participation in their sponsored technology transfer activities. The results of this effort are reported in this volume. In addition, the Compact has also developed a framework for the development of evaluation methodologies to determine the effectiveness of technology transfer programs in performing their intended functions and in achieving desired impacts impacts in the producing community. The results of that work are provided in a separate volume.

  9. BULK VITRIFICATION TECHNOLOGY FOR THE TREATMENT AND IMMOBILIZATION OF LOW-ACTIVITY WASTE

    Energy Technology Data Exchange (ETDEWEB)

    ARD KE

    2011-04-11

    This report is one of four reports written to provide background information regarding immobilization technologies under consideration for supplemental immobilization of Hanford's low-activity waste. This paper is intended to provide the reader with general understanding of Bulk Vitrification and how it might be applied to immobilization of Hanford's low-activity waste.

  10. Bulk Vitrification Technology For The Treatment And Immobilization Of Low-Activity Waste

    International Nuclear Information System (INIS)

    Ard, K.E.

    2011-01-01

    This report is one of four reports written to provide background information regarding immobilization technologies under consideration for supplemental immobilization of Hanford's low-activity waste. This paper is intended to provide the reader with general understanding of Bulk Vitrification and how it might be applied to immobilization of Hanford's low-activity waste.

  11. Student Attitudes in the Transition to an Active-Learning Technology

    Science.gov (United States)

    Koretsky, Milo D.; Brooks, Bill J.

    2012-01-01

    Changes in student perceptions to a novel technology-based, active-learning pedagogy using a custom, sophisticated, personal response system called WISE were studied over the first five years it was used. Students tended to view active learning more favorably over time, particularly in regards to statements that required them to be interpretive of…

  12. A Joule-Heated Melter Technology For The Treatment And Immobilization Of Low-Activity Waste

    International Nuclear Information System (INIS)

    Kelly, S.E.

    2011-01-01

    This report is one of four reports written to provide background information regarding immobilization technologies remaining under consideration for supplemental immobilization of Hanford's low-activity waste. This paper provides the reader a general understanding of joule-heated ceramic lined melters and their application to Hanford's low-activity waste.

  13. Effects of a Physical Education Supportive Curriculum and Technological Devices on Physical Activity

    Science.gov (United States)

    Clapham, Emily Dean; Sullivan, Eileen C.; Ciccomascolo, Lori E.

    2015-01-01

    The purpose of this study was to examine the effects of a physical education supportive curriculum and technological devices, heart rate monitor (HRM) and pedometer (PED), on physical activity. A single-subject ABAB research design was used to examine amount and level of participation in physical activity among 106 suburban fourth and fifth…

  14. Exploration of Tensions in a Mobile-Technology Supported Fieldtrip: An Activity Theory Perspective

    Science.gov (United States)

    Lai, Chih-Hung; Chen, Fei-Ching; Yang, Jie-Chi

    2014-01-01

    The purpose of this study was to analyze how mobile technologies were incorporated and implemented in an outdoor learning activity. Two classes of primary school students participated in the experiment. Using activity theory as an analytical framework, it is found that underlying tensions provided rich insights into system dynamics and that…

  15. A JOULE-HEATED MELTER TECHNOLOGY FOR THE TREATMENT AND IMMOBILIZATION OF LOW-ACTIVITY WASTE

    Energy Technology Data Exchange (ETDEWEB)

    KELLY SE

    2011-04-07

    This report is one of four reports written to provide background information regarding immobilization technologies remaining under consideration for supplemental immobilization of Hanford's low-activity waste. This paper provides the reader a general understanding of joule-heated ceramic lined melters and their application to Hanford's low-activity waste.

  16. Technology and active agency of older adults living in service house environment.

    Science.gov (United States)

    Sallinen, Merja; Hentonen, Outi; Kärki, Anne

    2015-01-01

    The purpose of the study was to explore whether or not the assistive and safety technology that is currently used in service house environment supports the active agency of the elderly residents. Twelve purposively chosen elderly residents were interviewed. The data were analyzed by theory-driven content analysis using the modalities of the agency-model as a theoretical frame. The technological devices and systems partially support the active agency of the residents. Deterioration of their functioning seems to limit the use of devices as well as complicate their learning on how to use these systems. The respondents had only few insights of the possibilities that this technology could offer to them in their daily life and they were not expecting their functioning to improve in the future. The homeliness and intimacy of the environment was highly appreciated. Although the attitude towards technology was, in general, reserved, technology was seen as one possibility to support active agency. The current technologies seem to be designed from the needs of the organization and not from the needs of the residents. In the future, more emphasis needs to be put on designing individualized devices in cooperation with the users. Implications for Rehabilitation To support independence, autonomy and active agency of the older adults, the technological solutions must be based on perceived needs of the individual and the design should be adaptable to the functional limitations one has. Nursing staff's knowledge about assistive devices and technologies need to be updated on regular bases in order to be able to recommend appropriate devices for the elderly. Taking into account the fact that many older adults have mild to moderate memory problems as well as difficulties with vision and hearing, more attention needs to be paid to didactics, i.e. how the introduction and guidance of the use of new technologies, assistive devices or safety systems is best done with them.

  17. Gram-Scale Synthesis of Highly Active and Durable Octahedral PtNi Nanoparticle Catalysts for Proton Exchange Membrane Fuel Cell

    DEFF Research Database (Denmark)

    Choi, Juhyuk; Jang, Jue-Hyuk; Roh, Chi-Woo

    2018-01-01

    Proton exchange membrane fuel cells (PEMFC) are regarded as a promising renewable energy source for a future hydrogen energy society. However, highly active and durable catalysts are required for the PEMFCs because of their intrinsic high overpotential at the cathode and operation under the acidic...... condition for oxygen reduction reaction (ORR). Since the discovery of the exceptionally high surface activity of Pt3Ni(111), the octahedral PtNi nanoparticles have been synthesized and tested. Nonetheless, their milligram-scale synthesis method and poor durability make them unsuitable...

  18. Investigation of Oxygen Reduction Activity of Catalysts Derived from Co and Co/Zn Methyl-Imidazolate Frameworks in Proton Exchange Membrane Fuel Cells

    Energy Technology Data Exchange (ETDEWEB)

    Chong, Lina [Chemical Sciences and Engineering Division, Argonne National Laboratory, Argonne IL 60439 USA; Engineering Research Center of Light Alloy Net Forming and State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai P.R. China; Goenaga, Gabriel A. [Chemical and Biomolecular Engineering Department, University of Tennessee, Knoxville, TN 37996 USA; Williams, Kia [University of South Florida, Tampa FL 33620 USA; Barkholtz, Heather M. [Chemical Sciences and Engineering Division, Argonne National Laboratory, Argonne IL 60439 USA; Grabstanowicz, Lauren R. [Alcoa Technical Center, New Kensington PA 15068 USA; Brooksbank, Jeremy A. [Chemical and Biomolecular Engineering Department, University of Tennessee, Knoxville, TN 37996 USA; Papandrew, Alex B. [Chemical and Biomolecular Engineering Department, University of Tennessee, Knoxville, TN 37996 USA; Elzein, Radwan [University of South Florida, Tampa FL 33620 USA; Schlaf, Rudiger [University of South Florida, Tampa FL 33620 USA; Zawodzinski, Thomas A. [Chemical and Biomolecular Engineering Department, University of Tennessee, Knoxville, TN 37996 USA; Zou, Jianxin [Engineering Research Center of Light Alloy Net Forming and State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai P.R. China; Ma, Shengqian [University of South Florida, Tampa FL 33620 USA; Liu, Di-Jia [Chemical Sciences and Engineering Division, Argonne National Laboratory, Argonne IL 60439 USA

    2016-05-31

    We demonstrated that the oxygen reduction reaction (ORR) activity over the catalysts derived from pyrolyzed cobalt zeolitic imidazolate frameworks depends strongly on the imidazole ligand structure and cobalt content. The activity and durability of these catalysts were tested in the proton exchange membrane fuel cell for the first time. The membrane electrode assembly containing a catalyst derived from Co/Zn bimetallic ZIF at cathode achieved an open circuit voltage of 0.93 V, a current density of 28 mA cm-2 at 0.8 ViR-free and a peak power density of 374 mW cm-2.

  19. Acclimation to high CO/sub 2/ in monoecious cucumbers. II. Carbon exchange rates, enzyme activities, and starch and nutrient concentrations. [Cucumis sativus L

    Energy Technology Data Exchange (ETDEWEB)

    Peet, M.M.; Huber, S.C.; Patterson, D.T.

    1986-01-01

    Carbon exchange capacity of cucumber (Cucumis sativus L.) germinated and grown in controlled environment chambers at 1000 microliters per liter CO/sub 2/ decreased from the vegetative growth stage to the fruiting stage, during which time capacity of plants grown at 350 microliters per liter increased. Carbon exchange rates (CERs) measured under growth conditions during the fruiting period were, in fact, lower in plants grown at 1000 microliters per liter CO/sub 2/ than those grown at 350. Progressive decreases in CERs in 1000 microliters per liter plants were associated with decreasing stomatal conductances and activities of ribulose bisphosphate carboxylase and carbonic anhydrase. Leaf starch concentrations were higher in 1000 microliters per liter CO/sub 2/ grown-plants than in 350 microliters per liter grown plants but calcium and nitrogen concentrations were lower, the greatest difference occurring at flowering. Sucrose synthase and sucrose-P-synthase activities were similar in 1000 microliters per liter compared to 350 microliters per liter plants during vegetative growth and flowering but higher in 350 microliters per liter plants at fruiting. The decreased carbon exchange rates observed in this cultivar at 1000 microliters per liter CO/sub 2/ could explain the lack of any yield increase when compared with plants grown at 350 microliters per liter.

  20. Dissecting the effect of RNA aptamer binding on the dynamics of plasminogen activator inhibitor 1 using hydrogen/deuterium exchange mass spectrometry.

    Science.gov (United States)

    Trelle, Morten B; Dupont, Daniel M; Madsen, Jeppe B; Andreasen, Peter A; Jørgensen, Thomas J D

    2014-01-17

    RNA aptamers, selected from large synthetic libraries, are attracting increasing interest as protein ligands, with potential uses as prototype pharmaceuticals, conformational probes, and reagents for specific quantification of protein levels in biological samples. Very little is known, however, about their effects on protein conformation and dynamics. We have employed hydrogen/deuterium exchange (HDX) mass spectrometry to study the effect of RNA aptamers on the structural flexibility of the serpin plasminogen activator inhibitor-1 (PAI-1). The aptamers have characteristic effects on the biochemical properties of PAI-1. In particular, they are potent inhibitors of the structural transition of PAI-1 from the active state to the inactive, so-called latent state. This transition is one of the largest conformational changes of a folded protein domain without covalent modification. Binding of the aptamers to PAI-1 is associated with substantial and widespread protection against deuterium uptake in PAI-1. The aptamers induce protection against exchange with the solvent both in the protein-aptamer interface as well as in other specific areas. Interestingly, the aptamers induce substantial protection against exchange in α-helices B, C and I. This observation substantiates the relevance of structural instability in this region for transition to the latent state and argues for involvement of flexibility in regions not commonly associated with regulation of latency transition in serpins.

  1. STEADY-STATE HEAT REJECTION RATES FOR A COAXIAL BOREHOLE HEAT EXCHANGER DURING PASSIVE AND ACTIVE COOLING DETERMINED WITH THE NOVEL STEP THERMAL RESPONSE TEST METHOD

    Directory of Open Access Journals (Sweden)

    Marija Macenić

    2018-01-01

    Full Text Available At three locations in Zagreb, classical and extended thermal response test (TRT was conducted on installed coaxial heat exchangers. With classic TR test, thermogeological properties of the ground and thermal resistance of the borehole were determined at each location. It is seen that thermal conductivity of the ground varies, due to difference in geological profile of the sites. In addition, experimental research of steady-state thermal response step test (SSTRST was carried out to determine heat rejection rates for passive and active cooling in steady state regime. Results showed that heat rejection rate is only between 8-11 W/m, which indicates that coaxial system is not suitable for passive cooling demands. Furthermore, the heat pump in passive cooling mode uses additional plate heat exchanger where there is additional temperature drop of working fluid by approximately 1,5 °C. Therefore, steady-state rejection rate for passive cooling is even lower for a real case project. Coaxial heat exchanger should be always designed for an active cooling regime with an operation of a heat pump compressor in a classical vapour compression refrigeration cycle.

  2. The impact of active controls technology on the structural integrity of aeronautical vehicles

    Science.gov (United States)

    Noll, Thomas E.; Austin, Edward; Donley, Shawn; Graham, George; Harris, Terry; Kaynes, Ian; Lee, Ben; Sparrow, James

    1993-01-01

    The findings of an investigation conducted under the auspices of The Technical Cooperation Program (TTCP) to assess the impact of active controls technology on the structural integrity of aeronautical vehicles and to evaluate the present state-of-the-art for predicting loads caused by a flight-control system modification and the resulting change in the fatigue life of the flight vehicle are summarized. Important points concerning structural technology considerations implicit in applying active controls technology in new aircraft are summarized. These points are well founded and based upon information received from within the aerospace industry and government laboratories, acquired by sponsoring workshops which brought together experts from contributing and interacting technical disciplines, and obtained by conducting a case study to independently assess the state of the technology. The paper concludes that communication between technical disciplines is absolutely essential in the design of future high performance aircraft.

  3. Separation of Cr(III) from Cr(VI) by Triton X-100 Cerium (Iv) Phosphate as a Surface Active Ion Exchanger

    International Nuclear Information System (INIS)

    El-Azony, K.M.; Ismail Aydia, M.; El-Mohty, A.A.

    2010-01-01

    A new and simple high-performance liquid chromatography (HPLC) method with ultraviolet (UV) detection has been developed for the determination of both Cr (III) and Cr (VI) ions. Chromium species were determined by HPLC using a stationary phase consisting of a reversed phase column (Nucleosil phenyl column; 250 mm x 4.6 mm,5 μm), and a mobile phase consisting of a mixture of methanol: water(70 : 30 v/v), in which the complexing agent di-(2-ethylhexyl) phosphoric acid (DEHPA) was dissolved. The UV detection was carried out at wavelength 650 nm. Separation of Cr (III) from Cr (VI) on Triton X-100 cerium(IV) phosphate(TX-100 CeP) as a surface active ion exchanger was investigated. TX-100 CeP has been synthesized, characterized using IR, X-Ray, TGA/DTA and elemental analysis. The ion exchange capacity and chemical stability in different HCl concentration have been studied

  4. Managing nuclear knowledge: IAEA activities and international coordination. Asian Network for Education in Nuclear Technology (ANENT)

    International Nuclear Information System (INIS)

    2007-07-01

    This CD-ROM is attached to the booklet 'Managing nuclear knowledge: IAEA activities and international coordination. Asian Network for Education in Nuclear Technology (ANENT)'. It contains the background material with regard to ANENT in full text, including policy level papers, reports, presentation material made by Member States, and meeting summaries during the period 2002-2005. Further information on the current ANENT activities and related IAEA activities is available at 'http://anent-iaea.org' and 'http://iaea.org/inisnkm'

  5. Inventive Activity and the Market for Technology in the United States, 1840-1920

    OpenAIRE

    Naomi R. Lamoreaux; Kenneth L. Sokoloff

    1999-01-01

    The growth of the U.S. economy over the nineteenth century was characterized by a sharp acceleration in the rate of inventive activity and a dramatic rise in the relative importance of highly specialized inventors as generators of new technological knowledge. Relying on evidence compiled from patent records, we argue that the evolution of a market for technology played a central role in these developments. Across both individuals and geographic areas, the expansion of opportunities to trade i...

  6. An Anion-Exchange Method for the Separation of P-32 Activity in Neutron-Irradiated Biological Material

    International Nuclear Information System (INIS)

    Samsahl, K.

    1964-06-01

    Strong hydrochloric-acid solutions containing small amounts of orthophosphoric and citric acid and radioactive tracers of the elements Na, P, K, Ca, Se, Cr, Mn, Ni, Rb, Sr, Cs, Ba, La, and Ce were titrated with a water suspension of strongly basic anion-exchange resin in the hydroxide form. The titration was carried out to pH = 3.0. It was followed by filtration of the mixture on the top of a small anion-exchange column in the chloride form and a final washing with water. Phosphorus was quantitatively adsorbed by the resin and the scandium retention was better than 96 per cent. The remaining elements passed quantitatively into the effluent, with the exception of nickel, which was adsorbed to a very small extent

  7. Hydrogen exchange

    DEFF Research Database (Denmark)

    Jensen, Pernille Foged; Rand, Kasper Dyrberg

    2016-01-01

    Hydrogen exchange (HX) monitored by mass spectrometry (MS) is a powerful analytical method for investigation of protein conformation and dynamics. HX-MS monitors isotopic exchange of hydrogen in protein backbone amides and thus serves as a sensitive method for probing protein conformation...... and dynamics along the entire protein backbone. This chapter describes the exchange of backbone amide hydrogen which is highly quenchable as it is strongly dependent on the pH and temperature. The HX rates of backbone amide hydrogen are sensitive and very useful probes of protein conformation......, as they are distributed along the polypeptide backbone and form the fundamental hydrogen-bonding networks of basic secondary structure. The effect of pressure on HX in unstructured polypeptides (poly-dl-lysine and oxidatively unfolded ribonuclease A) and native folded proteins (lysozyme and ribonuclease A) was evaluated...

  8. Activity Theory as a Framework for Investigating District-Classroom System Interactions and Their Influences on Technology Integration

    Science.gov (United States)

    Anthony, Anika Ball

    2012-01-01

    Technology implementation research indicates that teachers' beliefs and knowledge, as well as a host of institutional factors, can influence technology integration. Drawing on third-generation activity theory, this article conceptualizes technology implementation as a network of planning and integration activities carried out by technology…

  9. Combining active chilled beams and air cleaning technologies to improve indoor climate in offices

    DEFF Research Database (Denmark)

    Ardkapan, Siamak Rahimi; Afshari, Alireza; Bergsøe, Niels Christian

    2012-01-01

    This project is part of a long-term research programme studying the possibilities of using efficient air cleaning technologies to improve the indoor air quality in buildings. The purpose of this part of the project is to study energy-saving potential by combining cooling and cleaning of air in of....... Furthermore, the measurement results of the combined system showed that adding the filter accelerated the removal rate of the particles by 2 (h-1). However, the efficiency of the chilled beam in exchanging the heat reduced by 38%....... in offices. For this purpose, a mechanical filter with low pressure drop was selected to be tested in a laboratory environment. The measurements included tests of the filter in a ductwork to study the efficiency of the filter. Moreover, the combined system of the filter and a chilled beam was tested...

  10. Combining active chilled beams and air-cleaning technologies to improve the indoor climate in offices

    DEFF Research Database (Denmark)

    Ardkapan, Siamak Rahimi; Afshari, Alireza; Bergsøe, Niels Christian

    2013-01-01

    This project is part of a long-term research programme to study the possibilities of using efficient air-cleaning technologies to improve the indoor air quality in buildings. The purpose of this part of the project was to study the energy-saving potential of combining the cooling and cleaning of ...... than 5 Pa (0.104 Ibf /ft2). Furthermore, the measurement results of the combined system showed that adding the filter accelerated the removal rate of the particles by 2 h-1. However, the efficiency of the chilled beam in exchanging heat was reduced by 38%....... of air in offices. For this purpose, a mechanical filter with low pressure drop was selected for testing in a laboratory environment. The measurements included tests of the filter in a ductwork to study the efficiency of the filter. Moreover, the combined system of the filter and a chilled beam...

  11. Alternate particle removal technologies for the Airborne Activity Confinement System at the Savannah River Site

    International Nuclear Information System (INIS)

    Brockmann, J.E.; Adkins, C.L.J.; Gelbard, F.

    1991-09-01

    This report presents a review of the filtration technologies available for the removal of particulate material from a gas stream. It was undertaken to identify alternate filtration technologies that may be employed in the Airborne Activity Confinement System (AACS) at the Savannah River Plant. This report is organized into six sections: (1) a discussion of the aerosol source term and its definition, (2) a short discussion of particle and gaseous contaminant removal mechanisms, (3) a brief overview of particle removal technologies, (4) a discussion of the existing AACS and its potential shortcomings, (5) an enumeration of issues to be addressed in upgrading the AACS, and, (6) a detailed discussion of the identified technologies. The purpose of this report is to identity available options to the existing particle removal system. This system is in continuous operation during routine operation of the reactor. As will be seen, there are a number of options and the selection of any technology or combination of technologies will depend on the design aerosol source term (yet to be appropriately defined) as well as the flow requirements and configuration. This report does not select a specific technology. It focuses on particulate removal and qualitatively on the removal of radio-iodine and mist elimination. Candidate technologies have been selected from industrial and nuclear gas cleaning applications

  12. Alternate particle removal technologies for the Airborne Activity Confinement System at the Savannah River Site

    Energy Technology Data Exchange (ETDEWEB)

    Brockmann, J.E.; Adkins, C.L.J.; Gelbard, F. (Sandia National Labs., Albuquerque, NM (United States))

    1991-09-01

    This report presents a review of the filtration technologies available for the removal of particulate material from a gas stream. It was undertaken to identify alternate filtration technologies that may be employed in the Airborne Activity Confinement System (AACS) at the Savannah River Plant. This report is organized into six sections: (1) a discussion of the aerosol source term and its definition, (2) a short discussion of particle and gaseous contaminant removal mechanisms, (3) a brief overview of particle removal technologies, (4) a discussion of the existing AACS and its potential shortcomings, (5) an enumeration of issues to be addressed in upgrading the AACS, and, (6) a detailed discussion of the identified technologies. The purpose of this report is to identity available options to the existing particle removal system. This system is in continuous operation during routine operation of the reactor. As will be seen, there are a number of options and the selection of any technology or combination of technologies will depend on the design aerosol source term (yet to be appropriately defined) as well as the flow requirements and configuration. This report does not select a specific technology. It focuses on particulate removal and qualitatively on the removal of radio-iodine and mist elimination. Candidate technologies have been selected from industrial and nuclear gas cleaning applications.

  13. Active assistance technology for health-related behavior change: an interdisciplinary review.

    Science.gov (United States)

    Kennedy, Catriona M; Powell, John; Payne, Thomas H; Ainsworth, John; Boyd, Alan; Buchan, Iain

    2012-06-14

    Information technology can help individuals to change their health behaviors. This is due to its potential for dynamic and unbiased information processing enabling users to monitor their own progress and be informed about risks and opportunities specific to evolving contexts and motivations. However, in many behavior change interventions, information technology is underused by treating it as a passive medium focused on efficient transmission of information and a positive user experience. To conduct an interdisciplinary literature review to determine the extent to which the active technological capabilities of dynamic and adaptive information processing are being applied in behavior change interventions and to identify their role in these interventions. We defined key categories of active technology such as semantic information processing, pattern recognition, and adaptation. We conducted the literature search using keywords derived from the categories and included studies that indicated a significant role for an active technology in health-related behavior change. In the data extraction, we looked specifically for the following technology roles: (1) dynamic adaptive tailoring of messages depending on context, (2) interactive education, (3) support for client self-monitoring of behavior change progress, and (4) novel ways in which interventions are grounded in behavior change theories using active technology. The search returned 228 potentially relevant articles, of which 41 satisfied the inclusion criteria. We found that significant research was focused on dialog systems, embodied conversational agents, and activity recognition. The most covered health topic was physical activity. The majority of the studies were early-stage research. Only 6 were randomized controlled trials, of which 4 were positive for behavior change and 5 were positive for acceptability. Empathy and relational behavior were significant research themes in dialog systems for behavior change, with

  14. Using assistive technology adaptations to include students with learning disabilities in cooperative learning activities.

    Science.gov (United States)

    Bryant, D P; Bryant, B R

    1998-01-01

    Cooperative learning (CL) is a common instructional arrangement that is used by classroom teachers to foster academic achievement and social acceptance of students with and without learning disabilities. Cooperative learning is appealing to classroom teachers because it can provide an opportunity for more instruction and feedback by peers than can be provided by teachers to individual students who require extra assistance. Recent studies suggest that students with LD may need adaptations during cooperative learning activities. The use of assistive technology adaptations may be necessary to help some students with LD compensate for their specific learning difficulties so that they can engage more readily in cooperative learning activities. A process for integrating technology adaptations into cooperative learning activities is discussed in terms of three components: selecting adaptations, monitoring the use of the adaptations during cooperative learning activities, and evaluating the adaptations' effectiveness. The article concludes with comments regarding barriers to and support systems for technology integration, technology and effective instructional practices, and the need to consider technology adaptations for students who have learning disabilities.

  15. Effect of affordable technology on physical activity levels and mobility outcomes in rehabilitation: a protocol for the Activity and MObility UsiNg Technology (AMOUNT) rehabilitation trial

    Science.gov (United States)

    Hassett, Leanne; van den Berg, Maayken; Lindley, Richard I; Crotty, Maria; McCluskey, Annie; van der Ploeg, Hidde P; Smith, Stuart T; Schurr, Karl; Killington, Maggie; Bongers, Bert; Howard, Kirsten; Heritier, Stephane; Togher, Leanne; Hackett, Maree; Treacy, Daniel; Dorsch, Simone; Wong, Siobhan; Scrivener, Katharine; Chagpar, Sakina; Weber, Heather; Pearson, Ross; Sherrington, Catherine

    2016-01-01

    Introduction People with mobility limitations can benefit from rehabilitation programmes that provide a high dose of exercise. However, since providing a high dose of exercise is logistically challenging and resource-intensive, people in rehabilitation spend most of the day inactive. This trial aims to evaluate the effect of the addition of affordable technology to usual care on physical activity and mobility in people with mobility limitations admitted to inpatient aged and neurological rehabilitation units compared to usual care alone. Methods and analysis A pragmatic, assessor blinded, parallel-group randomised trial recruiting 300 consenting rehabilitation patients with reduced mobility will be conducted. Participants will be individually randomised to intervention or control groups. The intervention group will receive technology-based exercise to target mobility and physical activity problems for 6 months. The technology will include the use of video and computer games/exercises and tablet applications as well as activity monitors. The control group will not receive any additional intervention and both groups will receive usual inpatient and outpatient rehabilitation care over the 6-month study period. The coprimary outcomes will be objectively assessed physical activity (proportion of the day spent upright) and mobility (Short Physical Performance Battery) at 6 months after randomisation. Secondary outcomes will include: self-reported and objectively assessed physical activity, mobility, cognition, activity performance and participation, utility-based quality of life, balance confidence, technology self-efficacy, falls and service utilisation. Linear models will assess the effect of group allocation for each continuously scored outcome measure with baseline scores entered as a covariate. Fall rates between groups will be compared using negative binomial regression. Primary analyses will be preplanned, conducted while masked to group allocation and use an

  16. Effect of affordable technology on physical activity levels and mobility outcomes in rehabilitation: a protocol for the Activity and MObility UsiNg Technology (AMOUNT) rehabilitation trial.

    Science.gov (United States)

    Hassett, Leanne; van den Berg, Maayken; Lindley, Richard I; Crotty, Maria; McCluskey, Annie; van der Ploeg, Hidde P; Smith, Stuart T; Schurr, Karl; Killington, Maggie; Bongers, Bert; Howard, Kirsten; Heritier, Stephane; Togher, Leanne; Hackett, Maree; Treacy, Daniel; Dorsch, Simone; Wong, Siobhan; Scrivener, Katharine; Chagpar, Sakina; Weber, Heather; Pearson, Ross; Sherrington, Catherine

    2016-06-06

    People with mobility limitations can benefit from rehabilitation programmes that provide a high dose of exercise. However, since providing a high dose of exercise is logistically challenging and resource-intensive, people in rehabilitation spend most of the day inactive. This trial aims to evaluate the effect of the addition of affordable technology to usual care on physical activity and mobility in people with mobility limitations admitted to inpatient aged and neurological rehabilitation units compared to usual care alone. A pragmatic, assessor blinded, parallel-group randomised trial recruiting 300 consenting rehabilitation patients with reduced mobility will be conducted. Participants will be individually randomised to intervention or control groups. The intervention group will receive technology-based exercise to target mobility and physical activity problems for 6 months. The technology will include the use of video and computer games/exercises and tablet applications as well as activity monitors. The control group will not receive any additional intervention and both groups will receive usual inpatient and outpatient rehabilitation care over the 6-month study period. The coprimary outcomes will be objectively assessed physical activity (proportion of the day spent upright) and mobility (Short Physical Performance Battery) at 6 months after randomisation. Secondary outcomes will include: self-reported and objectively assessed physical activity, mobility, cognition, activity performance and participation, utility-based quality of life, balance confidence, technology self-efficacy, falls and service utilisation. Linear models will assess the effect of group allocation for each continuously scored outcome measure with baseline scores entered as a covariate. Fall rates between groups will be compared using negative binomial regression. Primary analyses will be preplanned, conducted while masked to group allocation and use an intention-to-treat approach. The

  17. Recent activities at MIT in the applications of acoustic emission technology for superconducting magnets

    International Nuclear Information System (INIS)

    Iwasa, Y.

    1988-01-01

    Recent activities at MIT in the applications of acoustic emission (AE) technology are presented. Specifically these activities include: acoustic- emission-technology based monitoring of and results from SCC dipole magnets, at both room temperature and 4.2 K, and the analytical and experimental study of acoustic signals emitted by epoxy-impregnated adiabatic superconducting magnets. The authors' preliminary results from the SSC dipoles support the notion that the principal source of premature quenches in these dipoles is dissipative mechanical events taking place within the winding and that the performance of these dipoles is furthermore critically dependent on the mechanical stiffness of the magnet structure

  18. The Na+/H+ exchanger, NHE1, differentially regulates mitogen-activated protein kinase subfamilies after osmotic shrinkage in Ehrlich Lettre Ascites cells

    DEFF Research Database (Denmark)

    Petersen, Stine Helene Falsig; Rasmussen, Maria; Darborg, Barbara Vasek

    2007-01-01

    Osmotic stress modulates mitogen activated protein kinase (MAPK) activities, leading to altered gene transcription and cell death/survival balance, however, the mechanisms involved are incompletely elucidated. Here, we show, using a combination of biochemical and molecular biology approaches......, that three MAPKs exhibit unique interrelationships with the Na(+)/H(+) exchanger, NHE1, after osmotic cell shrinkage: Extracellular Signal Regulated Kinase (ERK1/2) is inhibited in an NHE1-dependent, pH(i)-independent manner, c-Jun N-terminal kinase (JNK1/2) is stimulated, in part through NHE1-mediated...... intracellular alkalinization, and p38 MAPK is activated in an NHE1-independent manner, and contributes to NHE1 activation and ERK inhibition. Shrinkage-induced ERK1/2 inhibition was attenuated in Ehrlich Lettre Ascites cells by NHE1 inhibitors (EIPA, cariporide) or removal of extracellular Na(+), and mimicked...

  19. Technology.

    Science.gov (United States)

    Online-Offline, 1998

    1998-01-01

    Focuses on technology, on advances in such areas as aeronautics, electronics, physics, the space sciences, as well as computers and the attendant progress in medicine, robotics, and artificial intelligence. Describes educational resources for elementary and middle school students, including Web sites, CD-ROMs and software, videotapes, books,…

  20. Laser Technology.

    Science.gov (United States)

    Gauger, Robert

    1993-01-01

    Describes lasers and indicates that learning about laser technology and creating laser technology activities are among the teacher enhancement processes needed to strengthen technology education. (JOW)

  1. Heat exchangers

    International Nuclear Information System (INIS)

    1975-01-01

    The tubes of a heat exchanger tube bank have a portion thereof formed in the shape of a helix, of effective radius equal to the tube radius and the space between two adjacent tubes, to tangentially contact the straight sections of the tubes immediately adjacent thereto and thereby provide support, maintain the spacing and account for differential thermal expansion thereof

  2. Heat exchanger

    International Nuclear Information System (INIS)

    Wolowodiuk, W.

    1976-01-01

    A heat exchanger of the straight tube type is described in which different rates of thermal expansion between the straight tubes and the supply pipes furnishing fluid to those tubes do not result in tube failures. The supply pipes each contain a section which is of helical configuration

  3. Exchange Options

    NARCIS (Netherlands)

    Jamshidian, F.

    2007-01-01

    The contract is described and market examples given. Essential theoretical developments are introduced and cited chronologically. The principles and techniques of hedging and unique pricing are illustrated for the two simplest nontrivial examples: the classical Black-Scholes/Merton/Margrabe exchange

  4. Current mHealth technologies for physical activity assessment and promotion.

    Science.gov (United States)

    O'Reilly, Gillian A; Spruijt-Metz, Donna

    2013-10-01

    Novel mobile assessment and intervention capabilities are changing the face of physical activity (PA) research. A comprehensive systematic review of how mobile technology has been used for measuring PA and promoting PA behavior change is needed. Article collection was conducted using six databases from February to June 2012 with search terms related to mobile technology and PA. Articles that described the use of mobile technologies for PA assessment, sedentary behavior assessment, and/or interventions for PA behavior change were included. Articles were screened for inclusion and study information was extracted. Analyses were conducted from June to September 2012. Mobile phone-based journals and questionnaires, short message service (SMS) prompts, and on-body PA sensing systems were the mobile technologies most utilized. Results indicate that mobile journals and questionnaires are effective PA self-report measurement tools. Intervention studies that reported successful promotion of PA behavior change employed SMS communication, mobile journaling, or both SMS and mobile journaling. mHealth technologies are increasingly being employed to assess and intervene on PA in clinical, epidemiologic, and intervention research. The wide variations in technologies used and outcomes measured limit comparability across studies, and hamper identification of the most promising technologies. Further, the pace of technologic advancement currently outstrips that of scientific inquiry. New adaptive, sequential research designs that take advantage of ongoing technology development are needed. At the same time, scientific norms must shift to accept "smart," adaptive, iterative, evidence-based assessment and intervention technologies that will, by nature, improve during implementation. © 2013 American Journal of Preventive Medicine.

  5. Price of Fairness in Kidney Exchange

    Science.gov (United States)

    2014-05-01

    immensely, and provide valuable experi- ence in fielding real-world artificial intelligence technology . 2. FAIRNESS IN KIDNEY EXCHANGE In this section, we...exchange, a necessary consideration when fielding new technology in medicine (as noted by those who designed the recent deceased donor allocation scheme...Dynamic matching via weighted myopia with application to kidney exchange. In Proceedings of the National Conference on Artificial Intelligence (AAAI

  6. Business cycle and innovation activity in medium-high and high technology industry in Poland

    Directory of Open Access Journals (Sweden)

    Dzikowski Piotr

    2015-12-01

    Full Text Available This article examines differences in an impact of business cycle phases on innovation activity in medium-high and high technology industry in Poland. It is assumed that each business cycle phase influences innovation activity in the same fashion, but its impact varies and it depends on the firm’s innovation activity. The higher innovation activity the less impact of business cycle. The scope of the survey relates to innovation in MHT and HT industry in Poland. The data concerns the innovation at the firm level and the diffusion “new for the company”. Innovation activity is defined by the following activities: (1 expenditure on research and development and investments in fixed assets not used so far such as: abuildings, premises and land; b machinery and equipment, c computer software; (2 implementation of new products and technological processes and (3 innovation cooperation. The methodological part of the analysis includes a logit modeling. The survey includes 1355 companies. Business cycle has a great influence on innovation activity in MTH and HT industry in Poland. The influence of recovery phase is positive whereas both stagnation and recession phases decrease the probability of innovation activity. The character of influence depends on the propensity to take innovation activity. The higher level of innovation activity the enterprises present the less influence of business cycle they get.

  7. Future role and significance of space activities in reflection of global social, technological and economic trends

    Science.gov (United States)

    Diekmann, Andreas; Richarz, Hans.-Peter

    The paper describes the interrelation of space activities and global socio-economic trends like "globalisation of markets" and "renaissance of fine arts". The interrelation reveals the economic strategic, technological and scientific dimension of space activities and their benefits to mankind. Then, the significance and perspectives of space activities in these dimensions are examined in more detail. The paper calls (1) for a more visible initiative to employ space activities to tackle urgent questions of global change and development, and (2) for a stronger impetus to secure European economic position in space sector as a key industry of the 21st century.

  8. Local correlations for flap gap oscillatory blowing active flow control technology

    Directory of Open Access Journals (Sweden)

    Cătălin NAE

    2010-09-01

    Full Text Available Active technology for oscillatory blowing in the flap gap has been tested at INCAS subsonic wind tunnel in order to evaluate this technology for usage in high lift systems with active flow control. The main goal for this investigation was to validate TRL level 4 for this technology and to extend towards flight testing. CFD analysis was performed in order to identify local correlations with experimental data and to better formulate a design criteria so that a maximum increase in lift is possible under given geometrical constraints. Reference to a proposed metric for noise evaluation is also given. This includes basic 2D flow cases and also 2.5D configurations. In 2.5D test cases this work has been extended so that the proposed system may be selected as a mature technology in the JTI Clean Sky, Smart Fixed Wing Aircraft ITD. Complex post-processing of the experimental and CFD data was mainly oriented towards system efficiency and TRL evaluation for this active technology.

  9. Individual response technology to promote active learning within the caring sciences: An experimental research study.

    Science.gov (United States)

    Hedén, Lena; Ahlstrom, Linda

    2016-01-01

    One major challenge in delivering lectures to large and diverse classes is the maintenance of a high standard of lecturing in order to engage students and increase their participation and involvement. The lecturer's assignment is to arrange and prepare the lecture before teaching, hence enabling students' enhanced learning. Individual response technology could encourage students' active learning and activate higher cognitive levels. The aim of this study was to evaluate individual response technology as a complement during lectures for students in higher education, in terms of the students' experiences of participation, engagement, and active learning. Also of interest was whether this technology can be considered a supportive technical system. Data were collected through a questionnaire where levels of each condition were reported on a numeric rating scale (0-10) at baseline and after the introduction of individual response technology. To get a broader perspective, two types of lectures (pediatric and statistical) were included, giving a total of four assessment times. The participants comprised 59 students in Bachelor of Nursing program at a Swedish metropolitan university. Overall, when individual response technology was used, students reported increased experience of engagement (n=82, mean 6.1 vs. n=65, mean 7.3, pactive learning (n=92, mean 7.3 vs. n=79, mean 8.2 plectures (mean 6.6 vs. mean 8.1, plearning within the caring sciences. Copyright © 2015 Elsevier Ltd. All rights reserved.

  10. Information Technologies as a Tool for Agricultural Extension and Farmer-to-Farmer Exchange: Mobile-Phone Video Use in Mali and Burkina Faso

    Science.gov (United States)

    Sousa, Fernando; Nicolay, Gian; Home, Robert

    2016-01-01

    Mobile phones are widespread in the rural areas of Mali and Burkina Faso, but their potential as a tool for knowledge transfer by extension services in the region remains largely unexplored. The aim of this contribution is to evaluate the potential of video on mobile phones as a tool for farmer-to-farmer exchange and agricultural extension in…

  11. University Knowledge Exchange (KE) Framework: Good Practice in Technology Transfer. Report to the UK Higher Education Sector and HEFCE by the McMillan Group

    Science.gov (United States)

    Higher Education Funding Council for England, 2016

    2016-01-01

    As part of its commitment to keeping the UK at the leading edge as a global knowledge-based economy, the last Government asked the Higher Education Funding Council for England (HEFCE) in 2014 to develop a knowledge exchange (KE) performance framework that would secure effective practice in universities on key productive elements in the…

  12. Power and Thermal Technologies for Air and Space-Scientific Research Program. Delivery Order 0017: Study of Microchip Power Module Materials Using Mini-Channel Heat Exchanger

    Science.gov (United States)

    2009-12-01

    at the mid-point of the channels. In fabricating the heat exchanger, a method of attaching the inlet and exit flow tubes (stainless- steel 625 ) to...and the inlet/exit tubing. The mixing chambers ( Inconel 600) were machined as two pieces which were later welded together to make one chamber. The

  13. eHealth technologies to support nutrition and physical activity behaviors in diabetes self-management

    Directory of Open Access Journals (Sweden)

    Rollo ME

    2016-11-01

    Full Text Available Megan E Rollo,1 Elroy J Aguiar,2 Rebecca L Williams,1 Katie Wynne,3 Michelle Kriss,3 Robin Callister,4 Clare E Collins1 1School of Health Sciences, Faculty of Health and Medicine, Priority Research Centre for Physical Activity and Nutrition, University of Newcastle, Callaghan, NSW, Australia; 2Department of Kinesiology, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, MA, USA; 3Department of Diabetes and Endocrinology, John Hunter Hospital, Hunter New England Health, New Lambton, NSW, Australia;\t4School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, Priority Research Centre for Physical Activity and Nutrition, University of Newcastle, Callaghan, NSW, Australia Abstract: Diabetes is a chronic, complex condition requiring sound knowledge and self-management skills to optimize glycemic control and health outcomes. Dietary intake and physical activity are key diabetes self-management (DSM behaviors that require tailored education and support. Electronic health (eHealth technologies have a demonstrated potential for assisting individuals with DSM behaviors. This review provides examples of technologies used to support nutrition and physical activity behaviors in the context of DSM. Technologies covered include those widely used for DSM, such as web-based programs and mobile phone and smartphone applications. In addition, examples of novel tools such as virtual and augmented reality, video games, computer vision for dietary carbohydrate monitoring, and wearable devices are provided. The challenges to, and facilitators for, the use of eHealth technologies in DSM are discussed. Strategies to support the implementation of eHealth technologies within practice and suggestions for future research to enhance nutrition and physical activity behaviors as a part of broader DSM are provided. Keywords: diabetes self-management, eHealth, nutrition, physical activity, smartphones, wearables

  14. Educational Exchanges in Public Diplomacy: Russian and International Experience

    Directory of Open Access Journals (Sweden)

    Alexey Dolinkiy

    2014-01-01

    Full Text Available Education exchanges are a key element of public diplomacy for most countries that considered effective in that domain of foreign policy activities. Education exchanges are attributed an important role in the post-war peace settlement between Germany and France and in determining the outcome of the Cold war. Relevant aspects of public diplomacy remain key elements of foreign policy instruments of the US, Germany and many other countries. Russia has been increasingly active in public diplomacy in the past decade and the role of education exchanges has been increasing which is also demonstrated by a growing number of expert publications on the subject. However the strategy, the quality of organization and the use of modern technologies remain at a relatively low level which leads to an inefficient use of resources. Priority issues that can be a core of Russia's public diplomacy (and foreign policy in general. Moreover, systemic work would be required to evaluate efficiency of current and complete projects which would allow determine effectiveness of programs and appropriateness of resources used. Education exchanges need to be targeted at both bringing international students to Russia and assisting Russian students to study internationally and professors to teach abroad. Finally, international best practices show that there is a need to maintain connections with international exchanges alumni and assist them to maintain connections with each other including with the use of modern technologies.

  15. The articulated body. Physical activity, fitness and neew technologies of health

    DEFF Research Database (Denmark)

    Otto, Lene

    2010-01-01

    of anticipations of fit bodies as essential to individual health. I identify a physical activity discourse in which new modes of knowing, experiencing and doing bodies involve new types of health technologies in which bodies must be connected to mechanical and electronic appliances, inscribed with biomedical...... of physical exercise every day. These practices serve to maintain a particular way of understanding the body and how it can (or should) be enacted. Focusing on the role of physical activity and fitness in health promotion, I explore how physical exercise as a social-material technology, through which the body...... or an experiential phenomenon. Rather, it has been suggested, human bodies should be treated as contingent entanglements of social and material phenomena. Following this line I will investigate the relations between corporeal, scientific, and technologic practices and phenomena involved in the shaping...

  16. Designing for agency and compassion: Critical reflections on technology to support physical activity in late life

    DEFF Research Database (Denmark)

    Gerling, Kathrin M; Ray, Mo; Evans, Adam Brian

    leverage the lenses of critical gerontology and sports science to examine existing systems (including our own work on playful technologies), and discuss shortcomings along with strengths of present research to help guide discourse and future work in HCI. Moving beyond critical analysis, this paper outlines......Contemporary policy on ageing overwhelmingly focuses on active ageing and the increase of disability-free years. Consequently, the research community has adopted an agenda that broadly addresses the issue through technology interventions that focus on deficits of older persons, who are often viewed...... as a homogeneous group, and little consideration is given to the relationship between the ageing body and physical (in)activity, the impact of the life course, and implications of the acceptance of life stages. As a result, technology interventions are potentially effective on a functional level...

  17. Electronic Nose Technology to Measure Soil Microbial Activity and Classify Soil Metabolic Status

    OpenAIRE

    Fabrizio De Cesare; Elena Di Mattia; Simone Pantalei; Emiliano Zampetti; Vittorio Vinciguerra; Antonella Macagnano

    2011-01-01

    The electronic nose (E-nose) is a sensing technology that has been widely used to monitor environments in the last decade. In the present study, the capability of an E-nose, in combination with biochemical and microbiological techniques, of both detecting the microbial activity and estimating the metabolic status of soil ecosystems, was tested by measuring on one side respiration, enzyme activities and growth of bacteria in natural but simplified soil ecosystems over 23 days of incubation thr...

  18. Rockets: An Educator's Guide with Activities in Science, Mathematics, and Technology.

    Science.gov (United States)

    National Aeronautics and Space Administration, Washington, DC.

    This educational guide discusses rockets and includes activities in science, mathematics, and technology. It begins with background information on the history of rocketry, scientific principles, and practical rocketry. The sections on scientific principles and practical rocketry focus on Sir Isaac Newton's Three Laws of Motion. These laws explain…

  19. Teacher Perspectives on Technology Integration Professional Development: Formal, Informal, and Independent Learning Activities

    Science.gov (United States)

    Jones, Monty; Dexter, Sara

    2018-01-01

    This mixed-methods study examined the technology integration learning activities of four teachers throughout one year using weekly quantitative surveys and a series of three qualitative individual interviews. Through the teachers' own voices an illustration of their learning processes is presented, and the gap between what is supported by their…

  20. Pre-Service Teachers' Learning Styles and Preferences towards Instructional Technology Activities and Collaborative Works

    Science.gov (United States)

    Yusop, Farrah Dina; Sumari, Melati

    2015-01-01

    The main purpose of this exploratory study was to investigate pre-service teachers' learning styles and their preferences with respect to 15 technology-based instructional activities and collaborative work tasks. Felder and Silverman's online Index of Learning Style (ILS) and a questionnaire were used to measure students' learning styles and…

  1. 75 FR 81284 - Nationwide Use of High Frequency and Ultra High Frequency Active SONAR Technology; Draft...

    Science.gov (United States)

    2010-12-27

    ... frequencies of 50 kiloHertz (kHz) and greater from mobile platforms. Active SONAR technology would be used in support of USCG missions to locate, image, and classify submerged/underwater targets of interest (TOI... purpose of the Proposed Action is to broaden the USCG's capability to locate and classify underwater...

  2. 78 FR 70567 - Nationwide Use of High Frequency and Ultra High Frequency Active SONAR Technology; Final...

    Science.gov (United States)

    2013-11-26

    ... greater from fixed and mobile platforms. Active SONAR technology would be used in support of USCG missions to locate, image, and classify submerged/underwater targets of interest (TOI). The PEA is a program... Proposed Action is to broaden the USCG's capability to locate and classify underwater threats and other...

  3. Regulation of gene expression by manipulating transcriptional repressor activity using a novel CoSRI technology.

    Science.gov (United States)

    Xu, Yue; Li, Song Feng; Parish, Roger W

    2017-07-01

    Targeted gene manipulation is a central strategy for studying gene function and identifying related biological processes. However, a methodology for manipulating the regulatory motifs of transcription factors is lacking as these factors commonly possess multiple motifs (e.g. repression and activation motifs) which collaborate with each other to regulate multiple biological processes. We describe a novel approach designated conserved sequence-guided repressor inhibition (CoSRI) that can specifically reduce or abolish the repressive activities of transcription factors in vivo. The technology was evaluated using the chimeric MYB80-EAR transcription factor and subsequently the endogenous WUS transcription factor. The technology was employed to develop a reversible male sterility system applicable to hybrid seed production. In order to determine the capacity of the technology to regulate the activity of endogenous transcription factors, the WUS repressor was chosen. The WUS repression motif could be inhibited in vivo and the transformed plants exhibited the wus-1 phenotype. Consequently, the technology can be used to manipulate the activities of transcriptional repressor motifs regulating beneficial traits in crop plants and other eukaryotic organisms. © 2016 The Authors. Plant Biotechnology Journal published by Society for Experimental Biology and The Association of Applied Biologists and John Wiley & Sons Ltd.

  4. Teacher roles in designing technology-rich learning activities for early literacy

    NARCIS (Netherlands)

    Cviko, Amina; McKenney, Susan; Voogt, Joke

    2015-01-01

    The present study aims to provide insight into the value of different teacher roles in designing and implementing technology-rich learning activities for early literacy. Three cases, each with a different teacher role (executor-only, re-designer, co-designer) were examined. In the executor-only

  5. Machine Shop I. Learning Activity Packets (LAPs). Section B--Basic and Related Technology.

    Science.gov (United States)

    Oklahoma State Board of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This document contains eight learning activity packets (LAPs) for the "basic and related technology" instructional area of a Machine Shop I course. The eight LAPs cover the following topics: basic mathematics, blueprints, rules, micrometer measuring tools, Vernier measuring tools, dial indicators, gaging and inspection tools, and…

  6. Environmental control technology activities of the Department of Energy in FY 1977

    International Nuclear Information System (INIS)

    1977-11-01

    The Department of Energy is responsible for the research, development, and demonstration of emerging energy technologies and the promotion of energy conservation. An integral and significant part of that responsibility includes the balancing of energy goals with environmental requirements to protect and enhance the general health, safety, and welfare of the nation. This requires that environmental effects be considered and mitigating measures be taken in all energy processes through incorporation of environmental and safety controls which are developed as an integral part of energy system design. This inventory of environmental control technology activities was initiated by the Administrator, ERDA, prior to the incorporation of that administration within the Department of Energy. This compilation of total Energy Research and Development Administration (ERDA) environmental control technology activities, and associated funding, related to environmental control technology identifies the resources committed by ERDA to demonstrate its objective to protect and enhance the general health, safety, and welfare of the nation in the research, development, and demonstration of energy systems. Only ERDA research, development, and demonstration activities are covered in this report. The compilation for FY 1978 will encompass all of the DOE activities

  7. Suited for Spacewalking: A Teacher's Guide with Activities for Technology Education, Mathematics, and Science

    Science.gov (United States)

    Vogt, Gregory L.; George, Jane A. (Editor)

    1998-01-01

    A Teacher's Guide with Activities for Technology Education, Mathematics, and Science National Aeronautics and Space Administration Office of Human Resources and Education Education Division Washington, DC Education Working Group NASA Johnson Space Center Houston, Texas This publication is in the Public Domain and is not protected by copyright. Permission is not required for duplication.

  8. Using an Activity to Simulate the Dangers of Multitasking with Technology while Walking

    Science.gov (United States)

    Lazaros, Edward J.; Xu, Renmei; Londt, Susan

    2012-01-01

    People are increasingly trying to multitask while walking. Text messaging while walking is a significant area for concern. The number of text messages sent is expected to be more than 8 trillion in 2012. Texting is becoming so commonplace that people use this technology while engaged in other activities. The dangers of multitasking have hit the…

  9. Exchange potentials of phosphorus between sediments and water coupled to alkaline phosphatase activity and environmental factors in an oligo-mesotrophic reservoir.

    Science.gov (United States)

    Mhamdi, Badre Alaoui; Azzouzi, Assia; Elloumi, Jannet; Ayadi, Habib; Mhamdi, Mohammed Alaoui; Aleya, Lotfi

    2007-05-01

    We investigated the exchange potentials of phosphates at the water-sediment interface together with in situ benthic-chamber fractionated alkaline phosphatase activity and bacteria estimates during September and October 1998 at two stations: station 1, which received immediately the urban inputs from the Taounate city, and station 2, located in the centre of the Sahela reservoir (Morocco). The results showed that low oxygenation enhanced both the bacterial abundance and the alkaline phosphatase activity. Size-fractionated (0.65-100 microm) bacteria attached to dead organic matter together with algae and zooplankton contributed strongly (78%) to the total alkaline phosphatase synthesis in the two sampled stations, suggesting that attachment to organic particles stimulated phosphatase activities. The appearance of anoxic conditions and the decrease of pH supported the dissolution of particulate phosphorus and the release of soluble reactive phosphorus. This latter, together with persisting discharges of organic matter, sewage, and olive mill waste will exacerbate the eutrophication of the reservoir.

  10. Heat exchanger leakage problem location

    Directory of Open Access Journals (Sweden)

    Jícha Miroslav

    2012-04-01

    Full Text Available Recent compact heat exchangers are very often assembled from numerous parts joined together to separate heat transfer fluids and to form the required heat exchanger arrangement. Therefore, the leak tightness is very important property of the compact heat exchangers. Although, the compact heat exchangers have been produced for many years, there are still technological problems associated with manufacturing of the ideal connection between the individual parts, mainly encountered with special purpose heat exchangers, e.g. gas turbine recuperators. This paper describes a procedure used to identify the leakage location inside the prime surface gas turbine recuperator. For this purpose, an analytical model of the leaky gas turbine recuperator was created to assess its performance. The results obtained are compared with the experimental data which were acquired during the recuperator thermal performance analysis. The differences between these two data sets are used to indicate possible leakage areas.

  11. Ion exchange equilibrium constants

    CERN Document Server

    Marcus, Y

    2013-01-01

    Ion Exchange Equilibrium Constants focuses on the test-compilation of equilibrium constants for ion exchange reactions. The book first underscores the scope of the compilation, equilibrium constants, symbols used, and arrangement of the table. The manuscript then presents the table of equilibrium constants, including polystyrene sulfonate cation exchanger, polyacrylate cation exchanger, polymethacrylate cation exchanger, polysterene phosphate cation exchanger, and zirconium phosphate cation exchanger. The text highlights zirconium oxide anion exchanger, zeolite type 13Y cation exchanger, and

  12. Heat exchanger

    International Nuclear Information System (INIS)

    Bennett, J.C.

    1975-01-01

    A heat exchanger such as forms, for example, part of a power steam boiler is made up of a number of tubes that may be arranged in many different ways, and it is necessary that the tubes be properly supported. The means by which the tubes are secured must be as simple as possible so as to facilitate construction and must be able to continue to function effectively under the varying operating conditions to which the heat exchanger is subject. The arrangement described is designed to meet these requirements, in an improved way. The tubes are secured to a member extending past several tubes and abutment means are provided. At least some of the abutment means comprise two abutment pieces and a wedge secured to the supporting member, that acts on these pieces to maintain the engagement. (U.K.)

  13. Technology

    Directory of Open Access Journals (Sweden)

    Xu Jing

    2016-01-01

    Full Text Available The traditional answer card reading method using OMR (Optical Mark Reader, most commonly, OMR special card special use, less versatile, high cost, aiming at the existing problems proposed a method based on pattern recognition of the answer card identification method. Using the method based on Line Segment Detector to detect the tilt of the image, the existence of tilt image rotation correction, and eventually achieve positioning and detection of answers to the answer sheet .Pattern recognition technology for automatic reading, high accuracy, detect faster

  14. White paper on science and technology, 1996. Striving to become a front-runner in research activity

    International Nuclear Information System (INIS)

    1996-01-01

    This is the first report on policy measures implemented with regard to the promotion of science and technology, in accordance with Article 8 of the Science and Technology Basic Law, which was enacted in November 1995. Parts 1 and 2 of this report discuss trends in a wide range of scientific and technological activities to help the reader understand the policy measures implemented to promote science and technology. Part 1, titled 'Striving to become a front-runner in research activity', attempts and analysis of the public's expectations and demands concerning science and technology; of the state of affairs at institutions engaged in R and D; and of the issues that require attention in the pursuit of future of research activity. In Part 2, various types of data are used to compare Japan's scientific and technological activities with those in other major nations. And, Part 3 contains Policies implemented for the promotion of science and technology. (G.K.)

  15. Design Brief--Packaging: More than Just a Box! Communications: Getting the Message across with Advertising. Technology Learning Activities.

    Science.gov (United States)

    Technology Teacher, 1991

    1991-01-01

    Each technology learning activity in this article includes content description, objectives, required materials, challenge, and evaluation questions. Subjects are designing product packages and communication through advertising. (SK)

  16. Herpes simplex virus internalization into epithelial cells requires Na+/H+ exchangers and p21-activated kinases but neither clathrin- nor caveolin-mediated endocytosis.

    Science.gov (United States)

    Devadas, Deepika; Koithan, Thalea; Diestel, Randi; Prank, Ute; Sodeik, Beate; Döhner, Katinka

    2014-11-01

    Herpes simplex virus 1 (HSV-1) is an alphaherpesvirus that has been reported to infect some epithelial cell types by fusion at the plasma membrane but others by endocytosis. To determine the molecular mechanisms of productive HSV-1 cell entry, we perturbed key endocytosis host factors using specific inhibitors, RNA interference (RNAi), or overexpression of dominant negative proteins and investigated their effects on HSV-1 infection in the permissive epithelial cell lines Vero, HeLa, HEp-2, and PtK2. HSV-1 internalization required neither endosomal acidification nor clathrin- or caveolin-mediated endocytosis. In contrast, HSV-1 gene expression and internalization were significantly reduced after treatment with 5-(N-ethyl-N-isopropyl)amiloride (EIPA). EIPA blocks the activity of Na(+)/H(+) exchangers, which are plasma membrane proteins implicated in all forms of macropinocytosis. HSV-1 internalization furthermore required the function of p21-activated kinases that contribute to macropinosome formation. However, in contrast to some forms of macropinocytosis, HSV-1 did not enlist the activities of protein kinase C (PKC), tyrosine kinases, C-terminal binding protein 1, or dynamin to activate its internalization. These data suggest that HSV-1 depends on Na(+)/H(+) exchangers and p21-activated kinases either for macropinocytosis or for local actin rearrangements required for fusion at the plasma membrane or subsequent passage through the actin cortex underneath the plasma membrane. After initial replication in epithelial cells, herpes simplex viruses (HSVs) establish latent infections in neurons innervating these regions. Upon primary infection and reactivation from latency, HSVs cause many human skin and neurological diseases, particularly in immunocompromised hosts, despite the availability of effective antiviral drugs. Many viruses use macropinocytosis for virus internalization, and many host factors mediating this entry route have been identified, although the

  17. The articulated body. Physical activity, fitness and neew technologies of health

    DEFF Research Database (Denmark)

    Otto, Lene

    2010-01-01

    of anticipations of fit bodies as essential to individual health. I identify a physical activity discourse in which new modes of knowing, experiencing and doing bodies involve new types of health technologies in which bodies must be connected to mechanical and electronic appliances, inscribed with biomedical...... discourses. The growing significance of obesity has meant that scientific measurements of physical activity and fitness are ubiquitous in the Western world. Health promotion campaigns persuade the population to meet expectations of normality by encouraging participation in a certain number of minutes...... of physical exercise every day. These practices serve to maintain a particular way of understanding the body and how it can (or should) be enacted. Focusing on the role of physical activity and fitness in health promotion, I explore how physical exercise as a social-material technology, through which the body...

  18. Research on active imaging information transmission technology of satellite borne quantum remote sensing

    Science.gov (United States)

    Bi, Siwen; Zhen, Ming; Yang, Song; Lin, Xuling; Wu, Zhiqiang

    2017-08-01

    According to the development and application needs of Remote Sensing Science and technology, Prof. Siwen Bi proposed quantum remote sensing. Firstly, the paper gives a brief introduction of the background of quantum remote sensing, the research status and related researches at home and abroad on the theory, information mechanism and imaging experiments of quantum remote sensing and the production of principle prototype.Then, the quantization of pure remote sensing radiation field, the state function and squeezing effect of quantum remote sensing radiation field are emphasized. It also describes the squeezing optical operator of quantum light field in active imaging information transmission experiment and imaging experiments, achieving 2-3 times higher resolution than that of coherent light detection imaging and completing the production of quantum remote sensing imaging prototype. The application of quantum remote sensing technology can significantly improve both the signal-to-noise ratio of information transmission imaging and the spatial resolution of quantum remote sensing .On the above basis, Prof.Bi proposed the technical solution of active imaging information transmission technology of satellite borne quantum remote sensing, launched researches on its system composition and operation principle and on quantum noiseless amplifying devices, providing solutions and technical basis for implementing active imaging information technology of satellite borne Quantum Remote Sensing.

  19. ICT technologies and financial innovations: the case of Exchange Traded Funds in Brazil, Japan, Mexico, South Korea and the United States

    OpenAIRE

    Lechman, Ewa; Marszk, Adam

    2014-01-01

    Exchange traded funds (ETFs), funds structured in order to mimic the performance of selected financial assets, are one of the most significant innovative financial instruments recently introduced. They have gained considerable popularity among investors due to their advantages in comparison with conventional mutual funds, investment vehicles with a significantly longer history. This paper contributes by providing extensive knowledge about the empirical links between information and communicat...

  20. Recent status of research activities for development of CTBT-related technologies in JAERI

    International Nuclear Information System (INIS)

    Hirota, Naoki; Houkida, Takanori; Inoue, Yoji

    2003-08-01

    This report describes research activities of the R and D Group for Non-Proliferation Technology related to the Comprehensive Nuclear-Test-Ban Treaty (CTBT) verification regime. The main subjects of this report are (1) an overview of the CTBT verification regime, (2) preparation of the National Data Center for radionuclide data, (3) construction and operation of the radionuclide monitoring stations at Takasaki and Okinawa and the certified radionuclide laboratory at Tokai in Japan. We have participated in an intercomparison test internationally organized for the certified laboratories and the test results are given here. Scientific application of the CTBT-related technologies to environmental researches is also depicted. (author)

  1. Technology solutions to support supervisory activities and also to provide information access to the society

    Science.gov (United States)

    Paladini, D.; Mello, A. B.

    2016-07-01

    Inmetro's data about the conformity of certificated products, process and services are, usually, displayed at fragmented databases of difficult access for several reasons, for instance, the lack of computational solutions which allow this kind of access to its users. A discussion about some of the technological solutions to support supervisory activities by the appropriate regulatory bodies and also to provide information access to society in general is herein presented, along with a theoretical explanation of the pros and cons of such technologies to the conclusion that a mobile platform seems to be the best tool for the requirements of Inmetro.

  2. Prototype Active Silicon Sensor in 150 nm HR-CMOS Technology for ATLAS Inner Detector Upgrade

    CERN Document Server

    Rymaszewski, Piotr; Breugnon, Patrick; Godiot, Stépahnie; Gonella, Laura; Hemperek, Tomasz; Hirono, Toko; Hügging, Fabian; Krüger, Hans; Liu, Jian; Pangaud, Patrick; Peric, Ivan; Rozanov, Alexandre; Wang, Anqing; Wermes, Norbert

    2016-01-01

    The LHC Phase-II upgrade will lead to a significant increase in luminosity, which in turn will bring new challenges for the operation of inner tracking detectors. A possible solution is to use active silicon sensors, taking advantage of commercial CMOS technologies. Currently ATLAS R&D programme is qualifying a few commercial technologies in terms of suitability for this task. In this paper a prototype designed in one of them (LFoundry 150 nm process) will be discussed. The chip architecture will be described, including different pixel types incorporated into the design, followed by simulation and measurement results.

  3. Research and development activities for radioactive wastes treatment. Developing technologies of Kawasaki Heavy Industries, Ltd

    International Nuclear Information System (INIS)

    Adachi, Junichi; Ozawa, Tamotsu; Ikemoto, Yoshikazu; Yamazaki, Seiichiro; Minami, Ryogo

    1995-01-01

    Kawasaki Heavy Industries, Ltd. has been performing the research and development activities for radioactive wastes treatment in parallel with the design and fabrication of the nuclear facilities and components since the construction of the Tokai No.1 power station of JAPCO. Main technologies developed by Kawasaki Heavy Industries, Ltd. in the field of radwaste management are for dismantling and cutting, compacting and melting, and storage. This paper describes a summary of the present status and future plan of the above-mentioned technologies. (author)

  4. Interaction Design Beyond the Product : Creating Technology-Enhanced Activity Spaces

    DEFF Research Database (Denmark)

    Kaptelinin, Victor; Bannon, Liam J.

    2012-01-01

    The field of interaction design to date has been predominantly concerned with designing products, that is, devices, systems, and more recently services. A growing body of theoretical and empirical analyses suggests that the scope of interaction design needs to be expanded: An explicit concern...... between intrinsic and extrinsic technology-enabled practice transformation, and foreground the need for interaction design research and practice to more directly deal with analysis and construction of technology-enhanced activity spaces. The implications of these notions for the research agenda...

  5. Leveraging Citizen Science and Information Technology for Population Physical Activity Promotion.

    Science.gov (United States)

    King, Abby C; Winter, Sandra J; Sheats, Jylana L; Rosas, Lisa G; Buman, Matthew P; Salvo, Deborah; Rodriguez, Nicole M; Seguin, Rebecca A; Moran, Mika; Garber, Randi; Broderick, Bonnie; Zieff, Susan G; Sarmiento, Olga Lucia; Gonzalez, Silvia A; Banchoff, Ann; Dommarco, Juan Rivera

    2016-05-15

    While technology is a major driver of many of society's comforts, conveniences, and advances, it has been responsible, in a significant way, for engineering regular physical activity and a number of other positive health behaviors out of people's daily lives. A key question concerns how to harness information and communication technologies (ICT) to bring about positive changes in the health promotion field. One such approach involves community-engaged "citizen science," in which local residents leverage the potential of ICT to foster data-driven consensus-building and mobilization efforts that advance physical activity at the individual, social, built environment, and policy levels. The history of citizen science in the research arena is briefly described and an evidence-based method that embeds citizen science in a multi-level, multi-sectoral community-based participatory research framework for physical activity promotion is presented. Several examples of this citizen science-driven community engagement framework for promoting active lifestyles, called "Our Voice", are discussed, including pilot projects from diverse communities in the U.S. as well as internationally. The opportunities and challenges involved in leveraging citizen science activities as part of a broader population approach to promoting regular physical activity are explored. The strategic engagement of citizen scientists from socio-demographically diverse communities across the globe as both assessment as well as change agents provides a promising, potentially low-cost and scalable strategy for creating more active, healthful, and equitable neighborhoods and communities worldwide.

  6. Technology Efficacy in Active Prosthetic Knees for Transfemoral Amputees: A Quantitative Evaluation

    Science.gov (United States)

    El-Sayed, Amr M.; Abu Osman, Noor Azuan

    2014-01-01

    Several studies have presented technological ensembles of active knee systems for transfemoral prosthesis. Other studies have examined the amputees' gait performance while wearing a specific active prosthesis. This paper combined both insights, that is, a technical examination of the components used, with an evaluation of how these improved the gait of respective users. This study aims to offer a quantitative understanding of the potential enhancement derived from strategic integration of core elements in developing an effective device. The study systematically discussed the current technology in active transfemoral prosthesis with respect to its functional walking performance amongst above-knee amputee users, to evaluate the system's efficacy in producing close-to-normal user performance. The performances of its actuator, sensory system, and control technique that are incorporated in each reported system were evaluated separately and numerical comparisons were conducted based on the percentage of amputees' gait deviation from normal gait profile points. The results identified particular components that contributed closest to normal gait parameters. However, the conclusion is limitedly extendable due to the small number of studies. Thus, more clinical validation of the active prosthetic knee technology is needed to better understand the extent of contribution of each component to the most functional development. PMID:25110727

  7. Critical contribution of Na+-Ca2+ exchanger to the Ca2+-mediated vasodilation activated in endothelial cells of resistance arteries.

    Science.gov (United States)

    Lillo, Mauricio A; Gaete, Pablo S; Puebla, Mariela; Ardiles, Nicolás M; Poblete, Inés; Becerra, Alvaro; Simon, Felipe; Figueroa, Xavier F

    2018-04-01

    Na + -Ca 2+ exchanger (NCX) contributes to control the intracellular free Ca 2+ concentration ([Ca 2+ ] i ), but the functional activation of NCX reverse mode (NCXrm) in endothelial cells is controversial. We evaluated the participation of NCXrm-mediated Ca 2+ uptake in the endothelium-dependent vasodilation of rat isolated mesenteric arterial beds. In phenylephrine-contracted mesenteries, the acetylcholine (ACh)-induced vasodilation was abolished by treatment with the NCXrm blockers SEA0400, KB-R7943, or SN-6. Consistent with that, the ACh-induced hyperpolarization observed in primary cultures of mesenteric endothelial cells and in smooth muscle of isolated mesenteric resistance arteries was attenuated by KB-R7943 and SEA0400, respectively. In addition, both blockers abolished the NO production activated by ACh in intact mesenteric arteries. In contrast, the inhibition of NCXrm did not affect the vasodilator responses induced by the Ca 2+ ionophore, ionomycin, and the NO donor, S-nitroso- N-acetylpenicillamine. Furthermore, SEA0400, KB-R7943, and a small interference RNA directed against NCX1 blunted the increase in [Ca 2+ ] i induced by ACh or ATP in cultured endothelial cells. The analysis by proximity ligation assay showed that the NO-synthesizing enzyme, eNOS, and NCX1 were associated in endothelial cell caveolae of intact mesenteric resistance arteries. These results indicate that the activation of NCXrm has a central role in Ca 2+ -mediated vasodilation initiated by ACh in endothelial cells of resistance arteries.-Lillo, M. A., Gaete, P. S., Puebla, M., Ardiles, N. M., Poblete, I., Becerra, A., Simon, F., Figueroa, X. F. Critical contribution of Na + -Ca 2+ exchanger to the Ca 2+ -mediated vasodilation activated in endothelial cells of resistance arteries.

  8. Sites involved in intra- and interdomain allostery associated with the activation of factor VIIa pinpointed by hydrogen-deuterium exchange and electron transfer dissociation mass spectrometry.

    Science.gov (United States)

    Song, Hongjian; Olsen, Ole H; Persson, Egon; Rand, Kasper D

    2014-12-19

    Factor VIIa (FVIIa) is a trypsin-like protease that plays an important role in initiating blood coagulation. Very limited structural information is available for the free, inactive form of FVIIa that circulates in the blood prior to vascular injury and the molecular details of its activity enhancement remain elusive. Here we have applied hydrogen/deuterium exchange mass spectrometry coupled to electron transfer dissociation to pinpoint individual residues in the heavy chain of FVIIa whose conformation and/or local interaction pattern changes when the enzyme transitions to the active form, as induced either by its cofactor tissue factor or a covalent active site inhibitor. Identified regulatory residues are situated at key sites across one continuous surface of the protease domain spanning the TF-binding helix across the activation pocket to the calcium binding site and are embedded in elements of secondary structure and at the base of flexible loops. Thus these residues are optimally positioned to mediate crosstalk between functional sites in FVIIa, particularly the cofactor binding site and the active site. Our results unambiguously show that the conformational allosteric activation signal extends to the EGF1 domain in the light chain of FVIIa, underscoring a remarkable intra- and interdomain allosteric regulation of this trypsin-like protease. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

  9. Nanomaterials-Enhanced Electrically Switched Ion Exchange Process for Water Treatment

    International Nuclear Information System (INIS)

    Lin, Yuehe; Choi, Daiwon; Wang, Jun; Bontha, Jagannadha R.

    2009-01-01

    The objective of our work is to develop an electrically switched ion exchange (ESIX) system based on conducting polymer/carbon nanotube (CNT) nanocomposites as a new and cost-effective approach for removal of radioactive cesium, chromate, and perchlorate from contaminated groundwater. The ESIX technology combines ion exchange and electrochemistry to provide a selective, reversible method for the removal of target species from wastewater. In this technique, an electroactive ion exchange layer is deposited on a conducting substrate, and ion uptake and elution are controlled directly by modulation of the potential of the layer. ESIX offers the advantages of highly-efficient use of electrical energy combined with no secondary waste generation. Recently, we have improved upon the ESIX process by modifying the conducting substrate with carbon nanotubes prior to the deposition of the electroactive ion exchanger. The nanomaterial-based electroactive ion exchange technology will remove cesium-137, chromate, and perchlorate rapidly from wastewater. The high porosity and high surface area of the electroactive ion exchange nanocomposites results in high loading capacity and minimize interferences for non-target species. Since the ion adsorption/desorption is controlled electrically without generating a secondary waste, this electrically active ion exchange process is a green process technology that will greatly reduce operating costs

  10. Exchanging information

    International Nuclear Information System (INIS)

    1971-01-01

    The Agency has a statutory mandate to foster 'the exchange of scientific and technical information on the peaceful uses of atomic energy'. The prime responsibility for this work within the Agency lies with the Division of Scientific and Technical Information, a part of the Department of Technical Operations. The Division accomplishes its task by holding conferences and symposia (Scientific Conferences Section), through the Agency Library, by publishing scientific journals, and through the International Nuclear Information System (INIS). The Computer Section of the Division, which offers services to the Agency as a whole, provides resources for the automation of data storage and retrieval. (author)

  11. Deletion mutants of the Escherichia coli K-12 mannitol permease: dissection of transport-phosphorylation, phospho-exchange, and mannitol-binding activities.

    Science.gov (United States)

    Grisafi, P L; Scholle, A; Sugiyama, J; Briggs, C; Jacobson, G R; Lengeler, J W

    1989-05-01

    We have constructed a series of deletion mutations of the cloned Escherichia coli K-12 mtlA gene, which encodes the mannitol-specific enzyme II of the phosphoenolpyruvate (PEP)-dependent carbohydrate phosphotransferase system. This membrane-bound permease consists of 637 amino acid residues and is responsible for the concomitant transport and phosphorylation of D-mannitol in E. coli. Deletions into the 3' end of mtlA were constructed by exonuclease III digestion. Restriction mapping of the resultant plasmids identified several classes of deletions that lacked approximately 5% to more than 75% of the gene. Immunoblotting experiments revealed that many of these plasmids expressed proteins within the size range predicted by the restriction analyses, and all of these proteins were membrane localized, which demonstrated that none of the C-terminal half of the permease is required for membrane insertion. Functional analyses of the deletion proteins, expressed in an E. coli strain deleted for the chromosomal copy of mtlA, showed that all but one of the strains containing confirmed deletions were inactive in transport and PEP-dependent phosphorylation of mannitol, but deletions removing up to at least 117 amino acid residues from the C terminus of the permease were still active in catalyzing phospho exchange between mannitol 1-phosphate and mannitol. A deletion protein that lacked 240 residues from the C terminus of the permease was inactive in phospho exchange but still bound mannitol with high affinity. These experiments localize sites important for transport and PEP-dependent phosphorylation to the extreme C terminus of the mannitol permease, sites important for phospho exchange to between residues 377 and 519, and sites necessary for mannitol binding to the N-terminal 60% of the molecule. The results are discussed with respect to the fact that the mannitol permease consists of structurally independent N- and C-terminal domains.

  12. Robot Vision to Monitor Structures in Invisible Fog Environments Using Active Imaging Technology

    Energy Technology Data Exchange (ETDEWEB)

    Park, Seungkyu; Park, Nakkyu; Baik, Sunghoon; Choi, Youngsoo; Jeong, Kyungmin [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-05-15

    Active vision is a direct visualization technique using a highly sensitive image sensor and a high intensity illuminant. Range-gated imaging (RGI) technique providing 2D and 3D images is one of emerging active vision technologies. The RGI technique extracts vision information by summing time sliced vision images. In the RGI system, objects are illuminated for ultra-short time by a high intensity illuminant and then the light reflected from objects is captured by a highly sensitive image sensor with the exposure of ultra-short time. The RGI system provides 2D and 3D image data from several images and it moreover provides clear images from invisible fog and smoke environment by using summing of time-sliced images. Nowadays, the Range-gated (RG) imaging is an emerging technology in the field of surveillance for security applications, especially in the visualization of invisible night and fog environment. Although RGI viewing was discovered in the 1960's, this technology is, nowadays, more and more applicable by virtue of the rapid development of optical and sensor technologies, such as highly sensitive imaging sensor and ultra-short pulse laser light. In contrast to passive vision systems, this technology enables operation even in harsh environments like fog and smoke. During the past decades, several applications of this technology have been applied in target recognition and in harsh environments, such as fog, underwater vision. Also, this technology has been demonstrated 3D imaging based on range-gated imaging. In this paper, a robot system to monitor structures in invisible fog environment is developed using an active range-gated imaging technique. The system consists of an ultra-short pulse laser device and a highly sensitive imaging sensor. The developed vision system is carried out to monitor objects in invisible fog environment. The experimental result of this newly approach vision system is described in this paper. To see invisible objects in fog

  13. Robot Vision to Monitor Structures in Invisible Fog Environments Using Active Imaging Technology

    International Nuclear Information System (INIS)

    Park, Seungkyu; Park, Nakkyu; Baik, Sunghoon; Choi, Youngsoo; Jeong, Kyungmin

    2014-01-01

    Active vision is a direct visualization technique using a highly sensitive image sensor and a high intensity illuminant. Range-gated imaging (RGI) technique providing 2D and 3D images is one of emerging active vision technologies. The RGI technique extracts vision information by summing time sliced vision images. In the RGI system, objects are illuminated for ultra-short time by a high intensity illuminant and then the light reflected from objects is captured by a highly sensitive image sensor with the exposure of ultra-short time. The RGI system provides 2D and 3D image data from several images and it moreover provides clear images from invisible fog and smoke environment by using summing of time-sliced images. Nowadays, the Range-gated (RG) imaging is an emerging technology in the field of surveillance for security applications, especially in the visualization of invisible night and fog environment. Although RGI viewing was discovered in the 1960's, this technology is, nowadays, more and more applicable by virtue of the rapid development of optical and sensor technologies, such as highly sensitive imaging sensor and ultra-short pulse laser light. In contrast to passive vision systems, this technology enables operation even in harsh environments like fog and smoke. During the past decades, several applications of this technology have been applied in target recognition and in harsh environments, such as fog, underwater vision. Also, this technology has been demonstrated 3D imaging based on range-gated imaging. In this paper, a robot system to monitor structures in invisible fog environment is developed using an active range-gated imaging technique. The system consists of an ultra-short pulse laser device and a highly sensitive imaging sensor. The developed vision system is carried out to monitor objects in invisible fog environment. The experimental result of this newly approach vision system is described in this paper. To see invisible objects in fog

  14. Changes in antagonistic activity of lactic acid bacteria induced by their response to technological factors

    Directory of Open Access Journals (Sweden)

    Dovile Jonkuviene

    2015-12-01

    Full Text Available This study examined the changes in antagonistic activity of selected lactic acid bacteria (LAB in response to technological factors used in food production. The antimicrobial activity of 12 selected LAB strains was assessed against the bacterial and fungal strains using the agar well diffusion method. Sodium chloride (NaCl 6.5–8.0%, glucose 20-30% and pH 4.0, pH 8.0 and higher were the most crucial factors in reducing the spectra of the microorganisms antagonized. Heating at 80 °C or 100 °C had a greater negative impact than 63 °C on the antifungal activity of LAB. Freezing at –72 °C eliminated the antifungal activity, or it changed from fungicidal to fungistatic. Although each LAB demonstrated the ability to retain antimicrobial activity induced by various technological factors, Lactococcus lactis 768/5 was superior in retaining high antimicrobial activity against tested indicator strains.

  15. Geographic Information Technologies as an outreach activity in geo-scientific education

    Science.gov (United States)

    Maman, Shimrit; Isaacson, Sivan; Blumberg, Dan G.

    2016-04-01

    In recent years, a decline in the rates of examinees in the academic track that were entitled to an enhanced matriculation certificate in scientific-technological education was reported in Israel. To confront this problem the Earth and Planetary Image Facility (EPIF) at Ben-Gurion University of the Negev fosters interdisciplinary exploration through educational programs that make use of the facility and its equipment and enable the empowerment of the community by understanding and appreciating science and technology. This is achieved by using Geographic Information Technologies (GIT) such as remote sensing and Geographical Information Systems (GIS) for geo-physical sciences in activities that combine theoretical background with hands-on activities. Monitoring Earth from space by satellites, digital atlases and virtual-based positioning applications are examples for fusion of spatial information (geographic) and technology that the activity is based on. GIT opens a new chapter and a recent history of Cartography starting from the collection of spatial data to its presentation and analysis. GIS have replaced the use of classical atlas books and offer a variety of Web-based applications that provide maps and display up-to-date imagery. The purpose of this workshop is to expose teachers and students to GITs which are applicable in every classroom. The activity imparts free geographic information systems that exist in cyberspace and accessible to single users as the Israeli national GIS and Google earth, which are based on a spatial data and long term local and global satellite imagery coverage. In this paper, our "Think global-Map Local" activity is presented. The activity uses GIS and change detection technologies as means to encourage students to explore environmental issues both around the globe and close to their surroundings. The students detect changes by comparing multi temporal images of a chosen site and learn how to map the alterations and produce change

  16. Magnetic Fusion Energy Technology Fellowship Program: Summary of program activities for calendar year 1985

    International Nuclear Information System (INIS)

    1985-01-01

    This report summarizes the activities of the US Department of Energy (DOE) Magnetic Fusion Energy Technology Fellowship program (MFETF) for the 1985 calendar year. The MFETF program has continued to support the mission of the Office of Fusion Energy (OFE) and its Division of Development and Technology (DDT) by ensuring the availability of appropriately trained engineering manpower needed to implement the OFE/DDT magnetic fusion energy agenda. This program provides training and research opportunities to highly qualified students at DOE-designated academic, private sector, and government magnetic fusion energy institutions. The objectives of the Magnetic Fusion Energy Technology Fellowship program are: (1) to provide support for graduate study, training, and research in magnetic fusion energy technology; (2) to ensure an adequate supply of appropriately trained manpower to implement the nation's magnetic fusion energy agenda; (3) to raise the visibility of careers in magnetic fusion energy technology and to encourage students to pursue such careers; and (4) to make national magnetic fusion energy facilities available for manpower training

  17. Information technology equipment cooling system

    Science.gov (United States)

    Schultz, Mark D.

    2014-06-10

    According to one embodiment, a system for removing heat from a rack of information technology equipment may include a sidecar indoor air to liquid heat exchanger that cools warm air generated by the rack of information technology equipment. The system may also include a liquid to liquid heat exchanger and an outdoor heat exchanger. The system may further include configurable pathways to connect and control fluid flow through the sidecar heat exchanger, the liquid to liquid heat exchanger, the rack of information technology equipment, and the outdoor heat exchanger based upon ambient temperature and/or ambient humidity to remove heat from the rack of information technology equipment.

  18. Effects of mill stream flours technological quality on fermentative activity of baker's yeast Saccharomyces cerevisiae

    Directory of Open Access Journals (Sweden)

    Mirić Katarina V.

    2008-01-01

    Full Text Available This work in concerned with the interdependence between technological quality of mill stream flours and fermentative activity of baker's yeast Saccharomyces cerevisiae. Each mill stream flour has its own specific properties, determined by the particle size, technological phase of its formation and part of the wheat kernel it consists of. Biochemical complexity of dough during examination of fermentative activity of baker's yeast confirmed the influence of a number of physical and biochemical flour properties, such as ash content, wet gluten content, rheological flour properties, phytic acid content and amylograph peak viscosity. Abudance of significant flour characteristic, their interaction and different behavior in the presence of the yeast, showed diversity and variation of result within the same category of the mill stream flour.

  19. Applications of hydrogen deuterium exchange (HDX for the characterization of conformational dynamics in light-activated photoreceptors

    Directory of Open Access Journals (Sweden)

    Robert eLindner

    2015-06-01

    Full Text Available Rational design of optogenetic tools is inherently linked to the understanding of photoreceptor function. Structural analysis of elements involved in signal integration in individual sensor domains provides an initial idea of their mode of operation, but understanding how local structural rearrangements eventually affect signal transmission to output domains requires inclusion of the effector regions in the characterization. However, the dynamic nature of these assemblies renders their structural analysis challenging and therefore a combination of high- and low-resolution techniques is required to appreciate functional aspects of photoreceptors.This review focuses on the potential of Hydrogen-Deuterium exchange coupled to mass spectrometry (HDX-MS for complementing the structural characterization of photoreceptors. In this respect, the ability of HDX-MS to provide information on the conformational dynamics and the possibility to address multiple functionally relevant states in solution render this methodology ideally suitable. We highlight recent examples demonstrating the potential of HDX-MS and discuss how these results can help to improve existing optogenetic systems or guide the design of novel optogenetic tools.

  20. Matchmaker Exchange.

    Science.gov (United States)

    Sobreira, Nara L M; Arachchi, Harindra; Buske, Orion J; Chong, Jessica X; Hutton, Ben; Foreman, Julia; Schiettecatte, François; Groza, Tudor; Jacobsen, Julius O B; Haendel, Melissa A; Boycott, Kym M; Hamosh, Ada; Rehm, Heidi L

    2017-10-18

    In well over half of the individuals with rare disease who undergo clinical or research next-generation sequencing, the responsible gene cannot be determined. Some reasons for this relatively low yield include unappreciated phenotypic heterogeneity; locus heterogeneity; somatic and germline mosaicism; variants of uncertain functional significance; technically inaccessible areas of the genome; incorrect mode of inheritance investigated; and inadequate communication between clinicians and basic scientists with knowledge of particular genes, proteins, or biological systems. To facilitate such communication and improve the search for patients or model organisms with similar phenotypes and variants in specific candidate genes, we have developed the Matchmaker Exchange (MME). MME was created to establish a federated network connecting databases of genomic and phenotypic data using a common application programming interface (API). To date, seven databases can exchange data using the API (GeneMatcher, PhenomeCentral, DECIPHER, MyGene2, matchbox, Australian Genomics Health Alliance Patient Archive, and Monarch Initiative; the latter included for model organism matching). This article guides usage of the MME for rare disease gene discovery. © 2017 by John Wiley & Sons, Inc. Copyright © 2017 John Wiley and Sons, Inc.

  1. Bringing it all back home? Backshoring of manufacturing activities and the adoption of Industry 4.0 technologies

    OpenAIRE

    Dachs, Bernhard; Kinkel, Steffen; Jäger, Angela

    2017-01-01

    We investigate the relationship between backshoring of production activities and investments in digital manufacturing technologies, also known as Industry 4.0. We argue that Industry 4.0 supports backshoring of manufacturing activities: First, because productivity increases by I4.0 technologies can neutralize cost advantages of offshoring locations and make labour arbitrage less appealing. Second, because increased flexibility provided by I4.0 technologies offers an incentive for firms to loc...

  2. Nuclear data measurement and evaluation activities for nuclear power technology applications

    International Nuclear Information System (INIS)

    Bioux, P.; Mouney, H.; Rowlands, J.L.

    1994-05-01

    Activity in the field of nuclear data for the fission power technology applications is reviewed. The present situation is of concern to the French nuclear industry because of the few measurement facilities which are now funded for work in the field and the reductions in the number of scientists expert in measurement and evaluation of nuclear data. It is argued that there are requirements which justify work to improve many items of nuclear data. (authors)

  3. Feasibility of popular m-health technologies for activity tracking among individuals with serious mental illness.

    Science.gov (United States)

    Naslund, John A; Aschbrenner, Kelly A; Barre, Laura K; Bartels, Stephen J

    2015-03-01

    Obesity prevalence is nearly double among individuals with serious mental illness (SMI), including schizophrenia spectrum disorders, bipolar disorder, or major depressive disorder, compared with the general population. Emerging mobile health (m-health) technologies are increasingly available and offer the potential to support lifestyle interventions targeting weight loss, yet the practical feasibility of using these technologies in this high-risk group has not been established. We evaluated the feasibility and acceptability of popular m-health technologies for activity tracking among overweight and obese individuals with SMI. We provided wearable activity monitoring devices (FitBit [San Francisco, CA] Zip™ or Nike Inc. [Beaverton, OR] FuelBand) and smartphones (Apple [Cupertino, CA] iPhone(®) 4S) for accessing the smartphone application for each device to participants with SMI enrolled in a weight loss program. Feasibility of these devices was measured by the frequency of use over time. Acceptability was measured through qualitative follow-up interviews with participants. Ten participants with SMI wore the devices for a mean of 89% (standard deviation=13%) of the days in the study. Five participants wore the devices 100% of the time. Participants reported high satisfaction, stating the devices were easy to use, helpful for setting goals, motivational, and useful for self-monitoring. Several participants liked the social connectivity feature of the devices where they could see each other's progress on the smartphone application, noting that "friendly" competition increased motivation to be more physically active. This study supports using popular m-health technologies for activity tracking among individuals with SMI. These findings can inform the design of weight loss interventions targeting this vulnerable patient population.

  4. Coupling ion-exchangers with inexpensive activated carbon fiber electrodes to enhance the performance of capacitive deionization cells for domestic wastewater desalination.

    Science.gov (United States)

    Liang, Peng; Yuan, Lulu; Yang, Xufei; Zhou, Shaoji; Huang, Xia

    2013-05-01

    A capacitive deionization (CDI) cell was built with electrodes made of an inexpensive commercial activated carbon fiber (ACF), and then modified by incorporating ion-exchangers into the cell compartment. Three modified CDI designs were tested: MCDI - a CDI with electrodes covered by ion-exchange membranes (IEMs) of the same polarity, FCDI - a CDI with electrodes covered by ion-exchange felts (IEFs), and R-MCDI - an MCDI with cell chamber packed with ion-exchange resin (IER) granules. The cell was operated in the batch reactor mode with an initial salt concentration of 1000 mg/L NaCl, a typical level of domestic wastewater. The desalination tests involved investigations of two consecutive operation stages of CDIs: electrical adsorption (at an applied voltage of 1.2 V) and desorption [including short circuit (SC) desorption and discharge (DC) desorption]. The R-MCDI showed the highest electric adsorption as measured in the present study by desalination rate [670 ± 20 mg/(L h)] and salt removal efficiency (90 ± 1%) at 60 min, followed by the MCDI [440 ± 15 mg/(L h) and 60 ± 2%, respectively]. The superior desalination performance of the R-MCDI over other designs was also affirmed by its highest charge efficiency (110 ± 7%) and fastest desorption rates at both the SC [1960 ± 15 mg/(L·h)] and DC [3000 ± 20 mg/(L·h)] modes. The desalination rate and salt removal efficiency of the R-MCDI increased from ∼270 mg/(L h) and 83% to ∼650 mg/(L h) and 98% respectively when the applied voltage increased from 0.6 V to 1.4 V, while decreased slightly when lowering the salt water flow rate that fed into the cell. The packing of IER granules in the R-MCDI provided additional surface area for ions transfer; meanwhile, according to the results of electrochemical impedance spectroscopy (EIS) analysis, it substantially lower down the R-MCDI's ohmic resistance, resulting in improved desalination performance. Copyright © 2013 Elsevier Ltd. All

  5. Separation of Cr(III) from Cr(VI) by Triton X-100 cerium(IV) phosphate as a surface active ion exchanger

    International Nuclear Information System (INIS)

    El-Azony, K.M.; Ismail Aydia, M.; El-Mohty, A.A.

    2011-01-01

    Triton X-100 cerium(IV) phosphate (TX-100CeP) was synthesized and characterized by using IR, X-ray, TGA/DT and the elemental analysis. The chemical stability of TX-100CeP versus the different concentrations of HCl acid was studied before and after its exposure to the radiation dose (30 K Gray). The effect of HCl concentration on separation of Cr(III) from Cr(VI) by using TX-100CeP as surface active ion exchanger was also studied. A novel method was achieved for the quantifying of Cr(III) and Cr(VI) ions by using the high-performance liquid chromatography (HPLC) at wavelength 650 nm, a stationary phase consists of reversed phase column (Nucleosil phenyl column; 250 x 4.6 mm, 5 μm), and a mobile phase consists of 0.001 M di-(2-ethylhexyl) phosphoric acid (DEHPA) in methanol:water (70:30 v/v). The retention times were 7.0 and 8.5 min, for the Cr(III) and Cr(VI), respectively. The exchange capacity of Cr(III) was quantified (2.1 meq/g) onto the TX-100CeP. (author)

  6. Activation and Inhibition of Sodium-Hydrogen Exchanger Is a Mechanism That Links the Pathophysiology and Treatment of Diabetes Mellitus With That of Heart Failure.

    Science.gov (United States)

    Packer, Milton

    2017-10-17

    The mechanisms underlying the progression of diabetes mellitus and heart failure are closely intertwined, such that worsening of one condition is frequently accompanied by worsening of the other; the degree of clinical acceleration is marked when the 2 coexist. Activation of the sodium-hydrogen exchanger in the heart and vasculature (NHE1 isoform) and the kidneys (NHE3 isoform) may serve as a common mechanism that links both disorders and may underlie their interplay. Insulin insensitivity and adipokine abnormalities (the hallmarks of type 2 diabetes mellitus) are characteristic features of heart failure; conversely, neurohormonal systems activated in heart failure (norepinephrine, angiotensin II, aldosterone, and neprilysin) impair insulin sensitivity and contribute to microvascular disease in diabetes mellitus. Each of these neurohormonal derangements may act through increased activity of both NHE1 and NHE3. Drugs used to treat diabetes mellitus may favorably affect the pathophysiological mechanisms of heart failure by inhibiting either or both NHE isoforms, and drugs used to treat heart failure may have beneficial effects on glucose tolerance and the complications of diabetes mellitus by interfering with the actions of NHE1 and NHE3. The efficacy of NHE inhibitors on the risk of cardiovascular events may be enhanced when heart failure and glucose intolerance coexist and may be attenuated when drugs with NHE inhibitory actions are given concomitantly. Therefore, the sodium-hydrogen exchanger may play a central role in the interplay of diabetes mellitus and heart failure, contribute to the physiological and clinical progression of both diseases, and explain certain drug-drug and drug-disease interactions that have been reported in large-scale randomized clinical trials. © 2017 American Heart Association, Inc.

  7. [The contribution of Web 2.0 technologies to the empowerment of active patients].

    Science.gov (United States)

    Oliver-Mora, Martí; Iñiguez-Rueda, Lupicinio

    2017-03-01

    The Spanish health system has recently been marked by the emergence of more active patients who are characterized as being better informed about their disease, having a more participatory attitude, wanting to have a greater influence in making decisions about their health and asserting their rights as patients. Therefore, this article aims to report on how the introduction of Web 2.0 technologies can contribute to the empowering of more active patients. To achieve this, 14 semi-structured interviews were conducted with patients and representatives of patient associations who have used Web 2.0 technologies to interact with other patients or to communicate with health professionals. From the results obtained, we highlight the fact that Web 2.0 technologies provide greater access to health-related information, improve communication between patients and health professionals, and enable the creation of new spaces of interaction among patients. All of the facts above contribute to the formation of a more active role on the part of patients.

  8. HybridPLAY: A New Technology to Foster Outdoors Physical Activity, Verbal Communication and Teamwork.

    Science.gov (United States)

    Díaz, Diego José; Boj, Clara; Portalés, Cristina

    2016-04-23

    This paper presents HybridPLAY, a novel technology composed of a sensor and mobile-based video games that transforms urban playgrounds into game scenarios. With this technology we aim to stimulate physical activity and playful learning by creating an entertaining environment in which users can actively participate and collaborate. HybridPLAY is different from other existing technologies that enhance playgrounds, as it is not integrated in them but can be attached to the different elements of the playgrounds, making its use more ubiquitous (i.e., not restricted to the playgrounds). HybridPLAY was born in 2007 as an artistic concept, and evolved after different phases of research and testing by almost 2000 users around the world (in workshops, artistic events, conferences, etc.). Here, we present the temporal evolution of HybridPLAY with the different versions of the sensors and the video games, and a detailed technical description of the sensors and the way interactions are produced. We also present the outcomes after the evaluation by users at different events and workshops. We believe that HybridPLAY has great potential to contribute to increased physical activity in kids, and also to improve the learning process and monitoring at school centres by letting users create the content of the apps, leading to new narratives and fostering creativity.

  9. HybridPLAY: A New Technology to Foster Outdoors Physical Activity, Verbal Communication and Teamwork

    Directory of Open Access Journals (Sweden)

    Diego José Díaz

    2016-04-01

    Full Text Available This paper presents HybridPLAY, a novel technology composed of a sensor and mobile-based video games that transforms urban playgrounds into game scenarios. With this technology we aim to stimulate physical activity and playful learning by creating an entertaining environment in which users can actively participate and collaborate. HybridPLAY is different from other existing technologies that enhance playgrounds, as it is not integrated in them but can be attached to the different elements of the playgrounds, making its use more ubiquitous (i.e., not restricted to the playgrounds. HybridPLAY was born in 2007 as an artistic concept, and evolved after different phases of research and testing by almost 2000 users around the world (in workshops, artistic events, conferences, etc.. Here, we present the temporal evolution of HybridPLAY with the different versions of the sensors and the video games, and a detailed technical description of the sensors and the way interactions are produced. We also present the outcomes after the evaluation by users at different events and workshops. We believe that HybridPLAY has great potential to contribute to increased physical activity in kids, and also to improve the learning process and monitoring at school centres by letting users create the content of the apps, leading to new narratives and fostering creativity.

  10. Educational Administrators’ Technological Leadership Efficacy and Perceptions towards Implementation Levels of Teaching and Learning Activities

    Directory of Open Access Journals (Sweden)

    Fatih ULUKAYA

    2017-12-01

    Full Text Available The aim of this study is to identify the educational administrators’ technological leadership efficacy (TLE and perceptions towards implementation levels of teaching and learning activities (ITLA, and then to present the contribution of the TLE as a predictor of the ITLA. We collected data from 112 educational administrators who are working in Tokat. According to the results of this study, educational administrators’ TLE level was “adequate” for only Digital age learning culture, for the other factors and the total of the TLE levels were “intermediate” level. According to ITLA results, all the sub-factors and total of the scale were “strongly agree” level. The technological leadership efficacy and perceptions towards implementation levels of teaching and learning activities differ according to educational administrators’ age, school type and working in town/city. There is a positive, medium level and significant correlation between educational administrators’ total scores of the TLE and ITLA. A simple linear regression was calculated to predict administrators’ perceptions towards implementation levels of teaching and learning activities based on their technological leadership efficacy, and TLE explains only 29% of the variation in ITLA.

  11. HybridPLAY: A New Technology to Foster Outdoors Physical Activity, Verbal Communication and Teamwork

    Science.gov (United States)

    Díaz, Diego José; Boj, Clara; Portalés, Cristina

    2016-01-01

    This paper presents HybridPLAY, a novel technology composed of a sensor and mobile-based video games that transforms urban playgrounds into game scenarios. With this technology we aim to stimulate physical activity and playful learning by creating an entertaining environment in which users can actively participate and collaborate. HybridPLAY is different from other existing technologies that enhance playgrounds, as it is not integrated in them but can be attached to the different elements of the playgrounds, making its use more ubiquitous (i.e., not restricted to the playgrounds). HybridPLAY was born in 2007 as an artistic concept, and evolved after different phases of research and testing by almost 2000 users around the world (in workshops, artistic events, conferences, etc.). Here, we present the temporal evolution of HybridPLAY with the different versions of the sensors and the video games, and a detailed technical description of the sensors and the way interactions are produced. We also present the outcomes after the evaluation by users at different events and workshops. We believe that HybridPLAY has great potential to contribute to increased physical activity in kids, and also to improve the learning process and monitoring at school centres by letting users create the content of the apps, leading to new narratives and fostering creativity. PMID:27120601

  12. Enhancing mental activity and cognitive independence through information and communication technologies in students pharmacist cosmetologist

    Directory of Open Access Journals (Sweden)

    B. S. Burlaka

    2014-08-01

    Full Text Available The aim of research is to summarize the techniques used at the Department of Drug Technologyof Zaporozhye State Medical University to enhance mental performance and cognitive independence of pharmacists-cosmetologistsstudent. Results and discussion.In order to present summary information on the characteristics of cause-effect relationships for students we use lecture as method of teaching. Duration of lectures is two academic hours. Students focus on the presentation of all the sections of thematic plan. Integrated information environment in the form of multimedia content promotes effective learning of complex material. Analysis and synthesis of information obtained in lectures is held in the practice. Practical solution on making one or another cosmetic form consists of several stages. So initially, students analyze the task, offering the use of auxiliary substances and rational technology manufacturing. Then collectively with the teacher discuss the proposed solution of the problem. We found that at the stage of finding an effective choice of ingredients and manufacturing techniques learning level of the studentsgrows. For efficient memorization of cosmetic manufacturing process it is efficiently to apply a lecture discussionas a method of teaching. A group of students was divided into subgroups, each of which expresses a reasoned point of view on the proposed manufacturing technology. Each subgroup is appropriate to include informal leaders who contribute to competition between subgroups and discussion the manufacturing techniques. It is especially efficiently to create educational discussion on the use of Internet technologies. The role of the teacher in this technique is effective in moderating the debate. Modern communication services and communication in the form of electronic mail systems, online forums, document management systems, and multimedia services offer unlimited opportunities to exchange any information. At the present stage

  13. Managing nuclear knowledge: IAEA activities and international coordination. Asian Network for Education in Nuclear Technology (ANENT)

    International Nuclear Information System (INIS)

    2007-07-01

    This booklet summarizes the main activities being carried out by the IAEA with regard to the Asian Network for Education in Nuclear Technology (ANENT) and other related activities including those completed during the period 2002-2005. It briefly describes the background information on the events leading to the formation of the ANENT; the terms of reference formulated at the second Coordination Committee meeting held in Vietnam, October 2005; and objectives, strategy and other institutional and managerial policies reaffirmed by the members. The attached CD-ROM contains nearly all of the background material in full text, including policy level papers, reports, presentations made by Member States, and meeting summaries

  14. Wind tunnel investigation of active controls technology applied to a DC-10 derivative

    Science.gov (United States)

    Winther, B. A.; Shirley, W. A.; Heimbaugh, R. M.

    1980-01-01

    Application of active controls technology to reduce aeroelastic response offers a potential for significant payoffs in terms of aerodynamic efficiency and structural weight. As part of the NASA Energy Efficient Transport program, the impact upon flutter and gust load characteristics has been investigated by means of analysis and low-speed wind tunnel tests of a semispan model. The model represents a DC-10 derivative with increased wing span and an active aileron surface, responding to vertical acceleration at the wing tip. A control law satisfying both flutter and gust load constraints is presented and evaluated. In general, the beneficial effects predicted by analysis are in good agreement with experimental data.

  15. PRTR ion exchange vault column sampling

    International Nuclear Information System (INIS)

    Cornwell, B.C.

    1995-01-01

    This report documents ion exchange column sampling and Non Destructive Assay (NDA) results from activities in 1994, for the Plutonium Recycle Test Reactor (PRTR) ion exchange vault. The objective was to obtain sufficient information to prepare disposal documentation for the ion exchange columns found in the PRTR Ion exchange vault. This activity also allowed for the monitoring of the liquid level in the lower vault. The sampling activity contained five separate activities: (1) Sampling an ion exchange column and analyzing the ion exchange media for purpose of waste disposal; (2) Gamma and neutron NDA testing on ion exchange columns located in the upper vault; (3) Lower vault liquid level measurement; (4) Radiological survey of the upper vault; and (5) Secure the vault pending waste disposal

  16. Digital imaging information technology for biospeckle activity assessment relative to bacteria and parasites.

    Science.gov (United States)

    Ramírez-Miquet, Evelio E; Cabrera, Humberto; Grassi, Hilda C; de J Andrades, Efrén; Otero, Isabel; Rodríguez, Dania; Darias, Juan G

    2017-08-01

    This paper reports on the biospeckle processing of biological activity using a visualization scheme based upon the digital imaging information technology. Activity relative to bacterial growth in agar plates and to parasites affected by a drug is monitored via the speckle patterns generated by a coherent source incident on the microorganisms. We present experimental results to demonstrate the potential application of this methodology for following the activity in time. The digital imaging information technology is an alternative visualization enabling the study of speckle dynamics, which is correlated to the activity of bacteria and parasites. In this method, the changes in Red-Green-Blue (RGB) color component density are considered as markers of the growth of bacteria and parasites motility in presence of a drug. The RGB data was used to generate a two-dimensional surface plot allowing an analysis of color distribution on the speckle images. The proposed visualization is compared to the outcomes of the generalized differences and the temporal difference. A quantification of the activity is performed using a parameterization of the temporal difference method. The adopted digital image processing technique has been found suitable to monitor motility and morphological changes in the bacterial population over time and to detect and distinguish a short term drug action on parasites.

  17. Perceived difficulties using everyday technology after acquired brain injury: influence on activity and participation.

    Science.gov (United States)

    Lindén, Anita; Lexell, Jan; Lund, Maria Larsson

    2010-12-01

    Using everyday technology (ET) is a prerequisite for activities and participation at home and in the community. It is well known that persons with an acquired brain injury (ABI) can have limitations in activities of daily living but our knowledge of their difficulties using ET is not known. Thirty-six persons (27 men and 9 women, mean age 44 years, age range 26-60) with an ABI (2-10 years post injury) were interviewed, using the Everyday Technology Use Questionnaire (ETUQ), about their perceived difficulties using ET and how these difficulties influenced their everyday activities and their possibilities to participate at home and in the community. A majority (78%) of the persons reported difficulties using ET. The most common difficulties were related to the use of telecommunication and computers. Despite these difficulties, a majority still used most objects and services independently. Twenty-six participants (72%) perceived that their difficulties using ET influenced their everyday activities and their possibility to participate at home and in the community. The results indicate that rehabilitation following an ABI should consider whether clients' use of ET influences their activity and participation and adopt interventions accordingly. The results also indicate that difficulties using ET need to be considered in the design of community services to prevent societal barriers.

  18. Electrically switched cesium ion exchange

    International Nuclear Information System (INIS)

    Lilga, M.A.; Orth, R.J.; Sukamto, J.P.H.; Schwartz, D.T.; Haight, S.M.; Genders, J.D.

    1997-04-01

    Electrically Switched Ion Exchange (ESIX) is a separation technology being developed as an alternative to conventional ion exchange for removing radionuclides from high-level waste. The ESIX technology, which combines ion exchange and electrochemistry, is geared toward producing electroactive films that are highly selective, regenerable, and long lasting. During the process, ion uptake and elution are controlled directly by modulating the potential of an ion exchange film that has been electrochemically deposited onto a high surface area electrode. This method adds little sodium to the waste stream and minimizes the secondary wastes associated with traditional ion exchange techniques. Development of the ESIX process is well underway for cesium removal using ferrocyanides as the electroactive films. Films having selectivity for perrhenate (a pertechnetate surrogate) over nitrate also have been deposited and tested. A case study for the KE Basin on the Hanford Site was conducted based on the results of the development testing. Engineering design baseline parameters for film deposition, film regeneration, cesium loading, and cesium elution were used for developing a conceptual system. Order of magnitude cost estimates were developed to compare with conventional ion exchange. This case study demonstrated that KE Basin wastewater could be processed continuously with minimal secondary waste and reduced associated disposal costs, as well as lower capital and labor expenditures

  19. Homeroom Activities in a College of Technology Based on the Master Plan

    Science.gov (United States)

    Fuchida, Kunihiiko; Murata, Hideaki; Yuji, Junichiro

    Homeroom (HR) activities have an important role in engineering education at technical colleges. Yatsushiro National College of Technology has made a master plan for them and has been putting the plan into practical use since 2002. This plan is comprehensive and has two main categories, social education and career guidance, both being composed of three sub-categories (e.g., self-understanding and making future plans) . Based on the master plan, each HR teacher makes his own plan for HR activities for his classroom at the beginning of the academic year. We have reached a consensus to share our practice and to improve HR activities for years to come. We also recognize that to carry out HR activities based on a master plan that reflects the school's educational goals is essential in order to train students who are well-prepared, both as engineers and as humans.

  20. PDIL's role in development of technology for production of heavy water from water by ammonia-water exchange (Preprint No. PM-7)

    International Nuclear Information System (INIS)

    Mukherjee, P.K.; Mishra, B.N.

    1989-04-01

    In the year 1980, the Department of Atomic Energy, (DAE), decided to set up a pilot plant for ammonia-water exchange process at Baroda. Based on basic data and information provided by DAE about basic process parameters such as flows, de uterium concentrations, temperatures, pressures, desired recovery effficiency etc, PDIL' s role included the following for the design and engineering of the pilot plant: (a) Process study for ammonia-water exchange system at an operating pressure of 20-30 Kg/Cm 2 and temperature in the range of 150-200degC. (b) Process study for ammonia-water rectification system to get water free ammonia in the overhead. (c) Process study of the ammonia-water stripping system for getting ammonia free water. Based on the above study a scheme has been prepared for a suitable sized pilot plant. This included the design and engineering of the pilot plant covering the above sections alongwith the piping, instruments, control and layout. The specifications for procurement of equipments and components including vendors' items were also prepared. The plant is totally independent of the fertilizer plant. (author)