WorldWideScience

Sample records for technology exchange activities

  1. Active microchannel heat exchanger

    Science.gov (United States)

    Tonkovich, Anna Lee Y [Pasco, WA; Roberts, Gary L [West Richland, WA; Call, Charles J [Pasco, WA; Wegeng, Robert S [Richland, WA; Wang, Yong [Richland, WA

    2001-01-01

    The present invention is an active microchannel heat exchanger with an active heat source and with microchannel architecture. The microchannel heat exchanger has (a) an exothermic reaction chamber; (b) an exhaust chamber; and (c) a heat exchanger chamber in thermal contact with the exhaust chamber, wherein (d) heat from the exothermic reaction chamber is convected by an exothermic reaction exhaust through the exhaust chamber and by conduction through a containment wall to the working fluid in the heat exchanger chamber thereby raising a temperature of the working fluid. The invention is particularly useful as a liquid fuel vaporizer and/or a steam generator for fuel cell power systems, and as a heat source for sustaining endothermic chemical reactions and initiating exothermic reactions.

  2. International Technology Exchange Division: 1993 Annual report

    Energy Technology Data Exchange (ETDEWEB)

    1993-12-31

    The Office of Technology Development (OTD) was established to ensure that reliable and acceptable technologies are available for implementation at DOE sites and that a technically trained work force is available to complete the EM mission by 2019. OTD established the International Technology Exchange Staff (ITES) to identify, evaluate, and acquire international technologies which can accelerate US DOE cleanup operations. ITES`s goal is to pursue international collaboration among government organizations, educational institutions, and private industry to identify world-wide needs and available technologies that will meet US environmental needs in general, and EM cleanup needs in particular; and establish mechanisms by which US government ER/WM technologies will be transferred to the US private sector for commercialization and export to international markets. ITES has developed the following strategic objectives to implement its international goals: develop and implement EM`s policy for international programs in accordance with DOE and US Government policies and regulations; establish efficient and predictable international technology transfer mechanisms; assist the US private sector in the commercialization and deployment of federally funded EM technologies and related knowledge in international markets; leverage US and non-US resources to accelerate international development and regulatory acceptance of EM technologies; contribute to the improvement of EM`s training of US students, scientists, and managers on international environmental issues. A summary and descriptions of program activities and accomplishments are given for 17 programs which comprise the four main areas of the ITES program: Activities with the Former Soviet Union, International Technology Transfer, International Cooperation, and Information Systems and Publications. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database.

  3. Ion-exchanged glass waveguide technology: a review

    Science.gov (United States)

    Tervonen, Ari; West, Brian R.; Honkanen, Seppo

    2011-07-01

    We review the history and current status of ion exchanged glass waveguide technology. The background of ion exchange in glass and key developments in the first years of research are briefly described. An overview of fabrication, characterization and modeling of waveguides is given and the most important waveguide devices and their applications are discussed. Ion exchanged waveguide technology has served as an available platform for studies of general waveguide properties, integrated optics structures and devices, as well as applications. It is also a commercial fabrication technology for both passive and active wave-guide components.

  4. International fuel cycle and waste management technology exchange activities sponsored by the United States Department of Energy: FY 1982 evaluation report

    Energy Technology Data Exchange (ETDEWEB)

    Lakey, L.T.; Harmon, K.M.

    1983-02-01

    In FY 1982, DOE and DOE contractor personnel attended 40 international symposia and conferences on fuel reprocessing and waste management subjects. The treatment of high-level waste was the topic most often covered in the visits, with geologic disposal and general waste management also being covered in numerous visits. Topics discussed less frequently inlcude TRU/LLW treatment, airborne waste treatment, D and D, spent fuel handling, and transportation. The benefits accuring to the US from technology exchange activities with other countries are both tangible, e.g., design of equipment, and intangible, e.g., improved foreign relations. New concepts initiated in other countries, particularly those with sizable nuclear programs, are beginning to appear in US efforts in growing numbers. The spent fuel dry storage concept originating in the FRG is being considered at numerous sites. Similarly, the German handling and draining concepts for the joule-heated ceramic melter used to vitrify wastes are being incorporated in US designs. Other foreigh technologies applicable in the US include the slagging incinerator (Belgium), the SYNROC waste form (Australia), the decontamination experience gained in decommissioning the Eurochemic reprocessing plant (Belgium), the engineered surface storage of low- and intermediate-level waste (Belgium, FRG, France), the air-cooled storage of vitrified high-level waste (France, UK), waste packaging (Canada, FRG, Sweden), disposal in salt (FRG), disposal in granite (Canada, Sweden), and sea dumping (UK, Belgium, The Netherlands, Switzerland). These technologies did not necessarily originated or have been tried in the US but for various reasons are now being applied and extended in other countries. This growing nuclear technological base in other countires reduces the number of technology avenues the US need follow to develop a solid nuclear power program.

  5. Laser Processed Condensing Heat Exchanger Technology Development

    Science.gov (United States)

    Hansen, Scott; Wright, Sarah; Wallace, Sarah; Hamilton, Tanner; Dennis, Alexander; Zuhlke, Craig; Roth, Nick; Sanders, John

    2017-01-01

    The reliance on non-permanent coatings in Condensing Heat Exchanger (CHX) designs is a significant technical issue to be solved before long-duration spaceflight can occur. Therefore, high reliability CHXs have been identified by the Evolvable Mars Campaign (EMC) as critical technologies needed to move beyond low earth orbit. The Laser Processed Condensing Heat Exchanger project aims to solve these problems through the use of femtosecond laser processed surfaces, which have unique wetting properties and potentially exhibit anti-microbial growth properties. These surfaces were investigated to identify if they would be suitable candidates for a replacement CHX surface. Among the areas researched in this project include microbial growth testing, siloxane flow testing in which laser processed surfaces were exposed to siloxanes in an air stream, and manufacturability.

  6. Thermally activated technologies: Technology Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2003-05-01

    The purpose of this Technology Roadmap is to outline a set of actions for government and industry to develop thermally activated technologies for converting America’s wasted heat resources into a reservoir of pollution-free energy for electric power, heating, cooling, refrigeration, and humidity control. Fuel flexibility is important. The actions also cover thermally activated technologies that use fossil fuels, biomass, and ultimately hydrogen, along with waste heat.

  7. Thermally activated technologies: Technology Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2003-05-01

    The purpose of this Technology Roadmap is to outline a set of actions for government and industry to develop thermally activated technologies for converting America’s wasted heat resources into a reservoir of pollution-free energy for electric power, heating, cooling, refrigeration, and humidity control. Fuel flexibility is important. The actions also cover thermally activated technologies that use fossil fuels, biomass, and ultimately hydrogen, along with waste heat.

  8. Active ageing technologies

    DEFF Research Database (Denmark)

    Lassen, Aske Juul

    the elderly. As part of this rearticulation of old age, many new technologies take form. This paper uses a wide concept of technologies (devices, regimes, strategies and ways of doing) and argues that technologies form active aging subjectivities, and on the other hand, that these subjectivities...... ‘sites of active aging’ in Denmark. By presenting three technologies of active aging (billiards at an activity center for elderly persons, dancing tiles for rehabilitation after falls and an online fitness community for elderly persons) the paper suggests that active aging is more than regimes...

  9. Brayton-cycle heat exchanger technology program

    Science.gov (United States)

    Killackey, J. J.; Coombs, M. G.; Graves, R. F.; Morse, C. J.

    1976-01-01

    The following five tasks designed to advance this development of heat exchanger systems for close loop Brayton cycle power systems are presented: (1) heat transfer and pressure drop data for a finned tubular heat transfer matrix. The tubes are arranged in a triangular array with copper stainless steel laminate strips helically wound on the tubes to form a disk fin geometry; (2) the development of a modularized waste heat exchanger. Means to provide verified double containment are described; (3) the design, fabrication, and test of compact plate fin heat exchangers representative of full scale Brayton cycle recuperators; (4) the analysis and design of bellows suitable for operation at 1600 F and 200 psia for 1,000 cycles and 50,000 hours creep life; and (5) screening tests used to select a low cost braze alloy with the desirable attributes of a gold base alloy. A total of 22 different alloys were investigated; the final selection was Nicrobraz 30.

  10. Implications of WWW technologies for exchanging medical records

    Directory of Open Access Journals (Sweden)

    Maurice Dixon

    1999-09-01

    Full Text Available This article addresses some of the implications for medical record exchange of very recent developments in technology and tools that support the World Wide Web. It argues that XML (Extensible Mark-up Language is a very good enabling technology for medical record exchange. XML provides a much cheaper way of executing the exchange of medical information that circumvents the need for proprietary software. Use of XML can also simplify solutions to the problems associated with coping with the evolution of medical systems in time. However XML on its own does not resolve all the semantic heterogeneities.

  11. INTERNATIONAL ENVIRONMENTAL TECHNOLOGY IDENTIFICATION, DEVELOPMENT, DEMONSTRATION, DEPLOYMENT AND EXCHANGE

    Energy Technology Data Exchange (ETDEWEB)

    Roy C. Herndon

    2001-02-28

    Cooperative Agreement (DE-FC21-95EW55101) between the U.S. Department of Energy (DOE) and the Florida State University's Institute for International Cooperative Environmental Research (IICER) was designed to facilitate a number of joint programmatic goals of both the DOE and the IICER related to international technology identification, development, demonstration and deployment using a variety of mechanisms to accomplish these goals. These mechanisms included: laboratory and field research; technology demonstrations; international training and technical exchanges; data collection, synthesis and evaluation; the conduct of conferences, symposia and high-level meetings; and other appropriate and effective approaches. The DOE utilized the expertise and facilities of the IICER at Florida State University to accomplish its goals related to this cooperative agreement. The IICER has unique and demonstrated capabilities that have been utilized to conduct the tasks for this cooperative agreement. The IICER conducted activities related to technology identification, development, evaluation, demonstration and deployment through its joint centers which link the capabilities at Florida State University with collaborating academic and leading research institutions in the major countries of Central and Eastern Europe (e.g., Czech Republic, Hungary, Poland) and Russia. The activities and accomplishments for this five-year cooperative agreement are summarized in this Final Technical Report.

  12. Extravehicular activity technology discipline

    Science.gov (United States)

    Webbon, Bruce W.

    1990-01-01

    Viewgraphs on extravehicular activity technology discipline for Space Station Freedom are presented. Topics covered include: extravehicular mobility unit; airlock and EMU support equipment; tools, mobility aids, and workstations; and telerobotic work aids interfaces.

  13. Boeing Technology Exposition & Exchange Brochure & Flyer

    OpenAIRE

    Phantom Works and Integrated Defense Systems / Advanced Systems

    2008-01-01

    Not open to the public - No foreign Nationals, Attendance Restricted by U.S. Export Regulations. The Expo is open only to Active Duty U.S. Military, U.S. GOvernment Civilian Personnel and Boeing invited Support Contractors, who are U.S. persons, will be required to sign a Proprietary Information Agreement with The Boeing Company. For more information visit: http://www.boeing.com/techexpo The documents attached include a NPS tri-fold brochure and a Tech Expo Flyer. Brochure regarding ...

  14. Understanding Thermal Activation Processes in Exchange Bias Systems

    Science.gov (United States)

    O'Grady, Kevin

    2007-03-01

    The phenomenon of exchange bias has been of major scientific interest and technological importance since the 1980s following its discovery by Meiklejohn and Bean in 1956 [1,2]. Following initial seminal work by Fulcomer and Charap [3] it has recently become clear that a major contribution to the phenomena of exchange bias derives from the fact that the grains in the antiferromagnetic (AF) layer are capable of thermally activated reorientation due to the exchange field from the ferromagnetic (F) layer. In this work careful measurement protocols will be presented that enable the thermal activation process to be analysed in considerable detail. More recently Hoffman [4] has described a spin reorientation process that occurs after the AF layer is set which leads to a large shift in the forward going hysteresis loop on the first reversal of the F layer. This effect, coupled to the thermal activation process, gives rise to the phenomenon of training whereby the loop progressively shifts from its original set direction towards the origin. Lastly we have observed a spin freezing phenomena at the interface that can be induced by either temperature or applied field which results in a systematic variation of the exchange bias. We interpret this effect as being due to paramagnetic like spins at the interface whose ordering leads to a significant increase in the overall value of the exchange bias. Thus we show that exchange bias is a complex convolution of at least three distinct effects, all of which will be described in detail. This explains why single theories of how this effect arises have been so unsuccessful during the last 50 years. [1] Meiklejohn and Bean: Physical Review vol.102 p.1413 (1956) [2] Nogues and Schuller: Journal of Magnetism and Magnetic Materials vol.192 p.203 (1999) [3] Fulcomer and Charap: Journal of Applied Physics vol.43 p.4190 (1972) [4] Hoffmann: Physical Review Letters vol.93 p.097203 (2004)

  15. ORGANIZATIONAL, LEGAL AND TECHNOLOGICAL ASPECTS OF HEALTH INFORMATION EXCHANGE

    Directory of Open Access Journals (Sweden)

    N. A. Karasev

    2017-01-01

    Full Text Available The article discusses organizational and legal aspects of electronic health information exchange in developed countries, particularly, introduction of electronic medical records in the United States and Europe, as well as topical issues related to standardization of information technologies in health care. We briefly describe the most popular standards used in e-medicine, such as Digital Imaging and Communications in Medicine (DICOM, openEHR and HL7. The questions of syntactic and semantic interoperability in the exchange of electronic medical records and some aspects of the digital signature use are also considered. We suggest mechanisms for implementation of electronic document management and sharing of digital medical information, as one of the most important directions of information technologies in health care. It is noted that today, the main limiting factor in providing the digital exchange of health information in Russian Federation is unresolved legal issues, i.e. the absence of a legal framework of electronic medical records share. At the same time, the level of IT development in our country is quite sufficient to meet current challenges. It is stated that, despite the unresolved number of problems (for example, completeness of medical data on a patient, given to relatives in critical situations, the adoption of a single electronic card is able to bring medical care to a new level, especially in emergency and urgent medicine.

  16. Enabling Detailed Energy Analyses via the Technology Performance Exchange: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Studer, D.; Fleming, K.; Lee, E.; Livingood, W.

    2014-08-01

    One of the key tenets to increasing adoption of energy efficiency solutions in the built environment is improving confidence in energy performance. Current industry practices make extensive use of predictive modeling, often via the use of sophisticated hourly or sub-hourly energy simulation programs, to account for site-specific parameters (e.g., climate zone, hours of operation, and space type) and arrive at a performance estimate. While such methods are highly precise, they invariably provide less than ideal accuracy due to a lack of high-quality, foundational energy performance input data. The Technology Performance Exchange was constructed to allow the transparent sharing of foundational, product-specific energy performance data, and leverages significant, external engineering efforts and a modular architecture to efficiently identify and codify the minimum information necessary to accurately predict product energy performance. This strongly-typed database resource represents a novel solution to a difficult and established problem. One of the most exciting benefits is the way in which the Technology Performance Exchange's application programming interface has been leveraged to integrate contributed foundational data into the Building Component Library. Via a series of scripts, data is automatically translated and parsed into the Building Component Library in a format that is immediately usable to the energy modeling community. This paper (1) presents a high-level overview of the project drivers and the structure of the Technology Performance Exchange; (2) offers a detailed examination of how technologies are incorporated and translated into powerful energy modeling code snippets; and (3) examines several benefits of this robust workflow.

  17. Information technology - Telecommunications and information exchange between systems - Private integrated services network - Inter-exchange signalling protocol - Message waiting indication supplementary service

    CERN Document Server

    International Organization for Standardization. Geneva

    2003-01-01

    Information technology - Telecommunications and information exchange between systems - Private integrated services network - Inter-exchange signalling protocol - Message waiting indication supplementary service

  18. Information technology - Telecommunications and information exchange between systems - Private integrated services network - Inter-exchange signalling protocol - Call priority interruption and call priority interruption protection supplementary services

    CERN Document Server

    International Organization for Standardization. Geneva

    2003-01-01

    Information technology - Telecommunications and information exchange between systems - Private integrated services network - Inter-exchange signalling protocol - Call priority interruption and call priority interruption protection supplementary services

  19. Information technology - Telecommunications and information exchange between systems - Private integrated services network - Inter-exchange signalling protocol - Wireless terminal authentication supplementary services

    CERN Document Server

    International Organization for Standardization. Geneva

    2003-01-01

    Information technology - Telecommunications and information exchange between systems - Private integrated services network - Inter-exchange signalling protocol - Wireless terminal authentication supplementary services

  20. Information technology - Telecommunications and information exchange between systems - Private integrated services network - Inter-exchange signalling protocol - Path replacement additional network feature

    CERN Document Server

    International Organization for Standardization. Geneva

    2003-01-01

    Information technology - Telecommunications and information exchange between systems - Private integrated services network - Inter-exchange signalling protocol - Path replacement additional network feature

  1. Information technology - Telecommunications and information exchange between systems - Private Integrated Services Network - Inter-exchange signalling protocol - Call interception additional network feature

    CERN Document Server

    International Organization for Standardization. Geneva

    2003-01-01

    Information technology - Telecommunications and information exchange between systems - Private Integrated Services Network - Inter-exchange signalling protocol - Call interception additional network feature

  2. Information technology - Telecommunications and information exchange between systems - Private integrated services network - Inter-exchange signalling protocol - Name identification supplementary services

    CERN Document Server

    International Organization for Standardization. Geneva

    2003-01-01

    Information technology - Telecommunications and information exchange between systems - Private integrated services network - Inter-exchange signalling protocol - Name identification supplementary services

  3. Information technology - Telecommunications and information exchange between systems - Private integrated services network - Inter-exchange signalling protocol - Single step call transfer supplementary service

    CERN Document Server

    International Organization for Standardization. Geneva

    2003-01-01

    Information technology - Telecommunications and information exchange between systems - Private integrated services network - Inter-exchange signalling protocol - Single step call transfer supplementary service

  4. Pressurized fluidized-bed combustion technology exchange workshop

    Energy Technology Data Exchange (ETDEWEB)

    ,

    1980-04-01

    The pressurized fluidized-bed combustion technology exchange workshop was held June 5 and 6, 1979, at The Meadowlands Hilton Hotel, Secaucus, New Jersey. Eleven papers have been entered individually into EDB and ERA. The papers include reviews of the US DOE and EPRI programs in this area and papers by Swedish, West German, British and American organizations. The British papers concern the joint program of the USA, UK and FRG at Leatherhead. The key factor in several papers is the use of fluidized bed combustors, gas turbines, and steam turbines in combined-cycle power plants. One paper examines several combined-cycle alternatives. (LTN)

  5. Investigation of Condensing Ice Heat Exchangers for MTSA Technology Development

    Science.gov (United States)

    Padilla, Sebastian; Powers, Aaron; Ball, Tyler; Lacomini, Christie; Paul, Heather L.

    2009-01-01

    Metabolic heat regenerated Temperature Swing Adsorption (MTSA) technology is being developed for thermal, carbon dioxide (CO2) and humidity control for a Portable Life Support Subsystem (PLSS). Metabolically-produced CO2 present in the ventilation gas of a PLSS is collected using a CO2-selective adsorbent via temperature swing adsorption. The temperature swing is initiated through cooling to well below metabolic temperatures. Cooling is achieved with a sublimation heat exchanger using water or liquid carbon dioxide (L CO2) expanded below sublimation temperature when exposed to low pressure or vacuum. Subsequent super heated vapor, as well as additional coolant, is used to further cool the astronaut. The temperature swing on the adsorbent is then completed by warming the adsorbent with a separate condensing ice heat exchanger (CIHX) using metabolic heat from moist ventilation gas. The condensed humidity in the ventilation gas is recycled at the habitat. The water condensation from the ventilation gas represents a significant source of potential energy for the warming of the adsorbent bed as it represents as much as half of the energy potential in the moist ventilation gas. Designing a heat exchanger to efficiently transfer this energy to the adsorbent bed and allow the collection of the water is a challenge since the CIHX will operate in a temperature range from 210K to 280K. The ventilation gas moisture will first freeze and then thaw, sometimes existing in three phases simultaneously.

  6. Liquid Salt Heat Exchanger Technology for VHTR Based Applications

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, Mark; Sridhara, Kumar; Allen, Todd; Peterson, Per

    2012-10-11

    The objective of this research is to evaluate performance of liquid salt fluids for use as a heat carrier for transferring high-temperature process heat from the very high-temperature reactor (VHTR) to chemical process plants. Currently, helium is being considered as the heat transfer fluid; however, the tube size requirements and the power associated with pumping helium may not be economical. Recent work on liquid salts has shown tremendous potential to transport high-temperature heat efficiently at low pressures over long distances. This project has two broad objectives: To investigate the compatibility of Incoloy 617 and coated and uncoated SiC ceramic composite with MgCl2-KCl molten salt to determine component lifetimes and aid in the design of heat exchangers and piping; and, To conduct the necessary research on the development of metallic and ceramic heat exchangers, which are needed for both the helium-to-salt side and salt-to-process side, with the goal of making these heat exchangers technologically viable. The research will consist of three separate tasks. The first task deals with material compatibility issues with liquid salt and the development of techniques for on-line measurement of corrosion products, which can be used to measure material loss in heat exchangers. Researchers will examine static corrosion of candidate materials in specific high-temperature heat transfer salt systems and develop an in situ electrochemical probe to measure metallic species concentrations dissolved in the liquid salt. The second task deals with the design of both the intermediate and process side heat exchanger systems. Researchers will optimize heat exchanger design and study issues related to corrosion, fabrication, and thermal stresses using commercial and in-house codes. The third task focuses integral testing of flowing liquid salts in a heat transfer/materials loop to determine potential issues of using the salts and to capture realistic behavior of the salts in a

  7. An active attack on a multiparty key exchange protocol

    Directory of Open Access Journals (Sweden)

    Reto Schnyder

    2016-01-01

    Full Text Available The multiparty key exchange introduced in Steiner et al. and presented in more general form by the authors is known to be secure against passive attacks. In this paper, an active attack is presented assuming malicious control of the communications of the last two users for the duration of only the key exchange.

  8. Advances in processing technologies for titanium heat exchanger tubes of fossil and nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Likhareva, T.P.; Tchizhik, A.A.; Chavchanidze, N.N. [Polzanov Central Boiler and Turbine Institute, St. Petersburg (Russian Federation)

    1998-12-31

    The advances in processing technologies for titanium heat exchangers with rolled and welded tubes of fossil and nuclear power plants in Russia are presented. The special methodology of investigations with constant small strain rate have been used to study the effects of mixed corrosion and creep processes in condensers cooled by sea or synthetic sea waters. The results of corrosion creep tests and K1scc calculations are given. The Russian science activities concerning condensers manufactured from titanium show the possibilities for designing structures with very high level service reliability in different corrosion aggressive mediums with high total salt, Cl-ion and oxygen contents. (orig.)

  9. Technology Solutions Case Study: Foundation Heat Exchanger, Oak Ridge, Tennessee

    Energy Technology Data Exchange (ETDEWEB)

    None

    2014-03-01

    The foundation heat exchanger, developed by Oak Ridge National Laboratory, is a new concept for a cost-effective horizontal ground heat exchanger that can be connected to water-to-water or water-to-air heat pump systems for space conditioning as well as domestic water heating.

  10. Sers-Active Silver Nanoparticles in Ion-Exchanged Glass

    Science.gov (United States)

    Chen, Ya; Jaakola, Janne; Säynätjoki, Antti; Tervonen, Ari; Honkanen, Seppo

    We study synthesis and SERS activity of glass-embedded ion-exchanged silver nanoparticles formed by two different methods. Silver-sodium ion-exchange process with heat treatment was utilized on commercial microscope slides, while masked ion-exchange technique was performed on glass Corning 0211. The distribution of particles was studied by absorption spectroscopy and atomic force microscopy. After etching the glass surface to expose the particles, SERS performance of these particles was investigated with micro-Raman spectroscopy using Rhodamine 6G as the analyte.

  11. Staff exchange with Spokane Intercollegiate Research and Technology Institute (SIRTI), final project report

    Energy Technology Data Exchange (ETDEWEB)

    Alexander, G.M.

    1994-12-01

    Staff exchanges, such as the one described in this report, are intended to facilitate communication and collaboration among scientists and engineers at Department of Energy (DOE) laboratories, in U.S. industry, and academia. Funding support for these exchanges is provided by the DOE, Office of Energy Research, Laboratory Technology Transfer Program. Funding levels for each exchange typically range from $20,000 to $40,000. The exchanges offer the opportunity for the laboratories to transfer technology and expertise to industry, gain a perspective on industry`s problems, and develop the basis for further cooperative efforts through Cooperative Research and Development Agreements (CRADAS) or other mechanisms.

  12. Allosteric activation of coagulation factor VIIa visualized by hydrogen exchange

    DEFF Research Database (Denmark)

    Rand, Kasper Dyrberg; Jørgensen, Thomas; Olsen, Ole H;

    2006-01-01

    Coagulation factor VIIa (FVIIa) is a serine protease that, after binding to tissue factor (TF), plays a pivotal role in the initiation of blood coagulation. We used hydrogen exchange monitored by mass spectrometry to visualize the details of FVIIa activation by comparing the exchange kinetics...... tissue factor binding, FVIIa undergoes dramatic structural stabilization as indicated by decreased exchange rates localized throughout the protease domain and in distant parts of the light chain, spanning across 50A and revealing a concerted interplay between functional sites in FVIIa. The results...... of distinct molecular states, namely zymogen FVII, endoproteolytically cleaved FVIIa, TF-bound zymogen FVII, TF-bound FVIIa, and FVIIa in complex with an active site inhibitor. The hydrogen exchange kinetics of zymogen FVII and FVIIa are identical indicating highly similar solution structures. However, upon...

  13. Japanese activities in refrigeration technology

    Science.gov (United States)

    Fujita, T.; Ohtsuka, T.; Ishizaki, Y.

    This paper reviews recent activities in refrigeration technology in Japan. The projects described are stimulated by growing industrial needs or form part of large national projects. The JNR project on the MAGLEV train is currently the most powerful activity and it demands knowledge in all the different disciplines of cryogenics in particular on various scales of refrigeration. Research activities are also directed towards the development of Stirling cycle and magnetic refrigerators for applications in a wider area.

  14. Key technology of ship product data exchange based on STEP

    Science.gov (United States)

    Shi, Dong-Yan; Yang, Jing-Tong; Qiu, Chang-Hua; Xue, Kai

    2005-06-01

    In this paper, in order to implement the share and exchange of the ship product data, a new kind of global function model is established. By researching on the development and trend of the application of ship STEP (standard for the exchange of product model data) standards, the AIM (application interpreted model) of AP216 is developed and improved as an example, aiming at the characteristics and practical engineering of ship industry in our country. The data exchange interfaces are formed based on STEP in the CAD/CAM for the ship by all function modules and shared databases under the global function model. The share and exchange of all information and data are solved in the design, manufacture and all life-cycle of ship products among different computer application systems. The research work makes foundation for the ship industry informatization.

  15. Key technology of ship product data exchange based on STEP

    Institute of Scientific and Technical Information of China (English)

    SHI Dong-yan; YANG Jing-tong; QIU Chang-hua; XUE Kai

    2005-01-01

    In this paper, in order to implement the share and exchange of the ship product data, a new kind of global function model is established. By researching on the development and trend of the application of ship STEP (standard for the exchange of product model data) standards, the AIM (application interpreted model) of AP216 is developed and improved as an example, aiming at the characteristics and practical engineering of ship industry in our country. The data exchange interfaces are formed based on STEP in the CAD/CAM for the ship by all function modules and shared databases under the global function model. The share and exchange of all information and data are solved in the design, manufacture and all life-cycle of ship products among different computer application systems. The research work makes foundation for the ship industry informatization.

  16. Active Osmotic Exchanger for Efficient Nanofiltration Inspired by the Kidney

    Directory of Open Access Journals (Sweden)

    Sophie Marbach

    2016-07-01

    Full Text Available In this paper, we investigate the physical mechanisms underlying one of the most efficient filtration devices: the kidney. Building on a minimal model of the Henle loop—the central part of the kidney filtration—we investigate theoretically the detailed out-of-equilibrium fluxes in this separation process in order to obtain absolute theoretical bounds for its efficiency in terms of separation ability and energy consumption. We demonstrate that this separation process operates at a remarkably small energy cost as compared to traditional sieving processes while working at much smaller pressures. This unique energetic efficiency originates in the double-loop geometry of the nephron, which operates as an active osmotic exchanger. The principles for an artificial-kidney-inspired filtration device could be readily mimicked based on existing soft technologies to build compact and low-energy artificial dialytic devices. Such a “kidney on a chip” also points to new avenues for advanced water recycling, targeting, in particular, sea-water pretreatment for decontamination and hardness reduction.

  17. Active Osmotic Exchanger for Efficient Nanofiltration Inspired by the Kidney

    Science.gov (United States)

    Marbach, Sophie; Bocquet, Lydéric

    2016-07-01

    In this paper, we investigate the physical mechanisms underlying one of the most efficient filtration devices: the kidney. Building on a minimal model of the Henle loop—the central part of the kidney filtration—we investigate theoretically the detailed out-of-equilibrium fluxes in this separation process in order to obtain absolute theoretical bounds for its efficiency in terms of separation ability and energy consumption. We demonstrate that this separation process operates at a remarkably small energy cost as compared to traditional sieving processes while working at much smaller pressures. This unique energetic efficiency originates in the double-loop geometry of the nephron, which operates as an active osmotic exchanger. The principles for an artificial-kidney-inspired filtration device could be readily mimicked based on existing soft technologies to build compact and low-energy artificial dialytic devices. Such a "kidney on a chip" also points to new avenues for advanced water recycling, targeting, in particular, sea-water pretreatment for decontamination and hardness reduction.

  18. Technology, Mathematics and Activity Theory

    Science.gov (United States)

    Lerman, Stephen

    2013-01-01

    This article describes 11 papers in which the authors report their research on technology as enhancement in the teaching and learning of mathematics, in the context of the application of activity theory for design and/or analysis. There is considerable diversity across the papers in how the authors have interpreted their task and in particular how…

  19. LITERATURE REVIEWS TO SUPPORT ION EXCHANGE TECHNOLOGY SELECTION FOR MODULAR SALT PROCESSING

    Energy Technology Data Exchange (ETDEWEB)

    King, W

    2007-11-30

    This report summarizes the results of literature reviews conducted to support the selection of a cesium removal technology for application in a small column ion exchange (SCIX) unit supported within a high level waste tank. SCIX is being considered as a technology for the treatment of radioactive salt solutions in order to accelerate closure of waste tanks at the Savannah River Site (SRS) as part of the Modular Salt Processing (MSP) technology development program. Two ion exchange materials, spherical Resorcinol-Formaldehyde (RF) and engineered Crystalline Silicotitanate (CST), are being considered for use within the SCIX unit. Both ion exchange materials have been studied extensively and are known to have high affinities for cesium ions in caustic tank waste supernates. RF is an elutable organic resin and CST is a non-elutable inorganic material. Waste treatment processes developed for the two technologies will differ with regard to solutions processed, secondary waste streams generated, optimum column size, and waste throughput. Pertinent references, anticipated processing sequences for utilization in waste treatment, gaps in the available data, and technical comparisons will be provided for the two ion exchange materials to assist in technology selection for SCIX. The engineered, granular form of CST (UOP IE-911) was the baseline ion exchange material used for the initial development and design of the SRS SCIX process (McCabe, 2005). To date, in-tank SCIX has not been implemented for treatment of radioactive waste solutions at SRS. Since initial development and consideration of SCIX for SRS waste treatment an alternative technology has been developed as part of the River Protection Project Waste Treatment Plant (RPP-WTP) Research and Technology program (Thorson, 2006). Spherical RF resin is the baseline media for cesium removal in the RPP-WTP, which was designed for the treatment of radioactive waste supernates and is currently under construction in Hanford, WA

  20. EXCHANGE

    Energy Technology Data Exchange (ETDEWEB)

    Boltz, J.C. (ed.)

    1992-09-01

    EXCHANGE is published monthly by the Idaho National Engineering Laboratory (INEL), a multidisciplinary facility operated for the US Department of Energy (DOE). The purpose of EXCHANGE is to inform computer users about about recent changes and innovations in both the mainframe and personal computer environments and how these changes can affect work being performed at DOE facilities.

  1. International Symposium for the Promotion of APEC Environmental Technology Exchange; APEC kankyo gijutsu koryu sokushin symposium

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-11-11

    The International Symposium for the Promotion of APEC Environmental Technology Exchange was held under the theme `The function and role expected of the APEC Virtual Center,` with the objectives of clarifying the need for future intra-regional environmental technological exchange, defining the types of information and personnel exchange, and promoting the use of interactive character of the APEC Virtual Center for Environmental Technology Exchange by encouraging access to and participation in the Virtual Center project. It was held in the period of 11th and 12th, November in 1996, at the venue of Rinku International Convention Center in Osaka. The symposium was attended by 477 persons from nine countries, i.e., Australia, Canada, China, Indonesia, Korea, Philippines, Thailand, the US, and Japan, comprising staff members of intra-regional environment-related organizations. After the keynote speech, `Current status and tasks of environmental technology exchange`, and `Expected roles of the Virtual Center for Environmental Technology Exchange` were discussed. During the plenary session, the chairman summarized the symposium. This summary was carried on the Virtual Center homepage of the Internet

  2. Assembly Modeling of Heat Exchanger Based on VBA and ActiveX Technology%基于VBA和ActiveX技术的换热设备装配建模

    Institute of Scientific and Technical Information of China (English)

    古新; 董其伍; 刘敏珊

    2007-01-01

    将换热设备设计与计算机应用技术相结合,以三维造型和装配软件MDT为开发平台,利用内嵌于MDT内部的ActiveX自动化界面技术和VBA集成开发环境,进行新型高效节能换热设备装配仿真系统的开发与应用,能够明显降低设计成本、缩短设计周期、提高设计效率和质量,加快高效节能新产品、新技术的推广应用.该文研究了系统开发中涉及到的关键技术,并对系统的实现方法进行了实践.

  3. Description of emission control using fluidized-bed, heat-exchange technology

    Energy Technology Data Exchange (ETDEWEB)

    Vogel, G.J.; Grogan, P.J.

    1980-06-01

    Environmental effects of fluidized-bed, waste-heat recovery technology are identified. The report focuses on a particular configuration of fluidized-bed, heat-exchange technology for a hypothetical industrial application. The application is a lead smelter where a fluidized-bed, waste-heat boiler (FBWHB) is used to control environmental pollutants and to produce steam for process use. Basic thermodynamic and kinetic information for the major sulfur dioxide (SO/sub 2/) and NO/sub x/ removal processes is presented and their application to fluidized-bed, waste heat recovery technology is discussed. Particulate control in fluidized-bed heat exchangers is also discussed.

  4. Use of communication technologies in document exchange for the management of construction projects

    Directory of Open Access Journals (Sweden)

    Mesároš Peter

    2016-06-01

    Full Text Available Information and communication technologies represent a set of people, processes, technical and software tools providing collection, transport, storage and processing of data for distribution and presentation of information. Particularly communication systems are the main tool for information exchange. Of the other part, these technologies have a broad focus and use. One of them is the exchange of documents in the management of construction projects. Paper discusses the issue of exploitation level of communication technologies in construction project management. The main objective of this paper is to analyze exploitation level of communication technologies. Another aim of the paper is to compare exploitation level or rate of document exchange by electronic communication devices and face-to-face communication.

  5. Use of communication technologies in document exchange for the management of construction projects

    Science.gov (United States)

    Mesároš, Peter; Mandičák, Tomáš

    2016-06-01

    Information and communication technologies represent a set of people, processes, technical and software tools providing collection, transport, storage and processing of data for distribution and presentation of information. Particularly communication systems are the main tool for information exchange. Of the other part, these technologies have a broad focus and use. One of them is the exchange of documents in the management of construction projects. Paper discusses the issue of exploitation level of communication technologies in construction project management. The main objective of this paper is to analyze exploitation level of communication technologies. Another aim of the paper is to compare exploitation level or rate of document exchange by electronic communication devices and face-to-face communication.

  6. Development of a micro-heat exchanger with stacked plates using LTCC technology

    Directory of Open Access Journals (Sweden)

    E. Vásquez-Alvarez

    2010-09-01

    Full Text Available A green ceramic tape micro-heat exchanger was developed using Low Temperature Co-fired Ceramics technology (LTCC. The device was designed by using Computational Aided Design software and simulations were made using a Computational Fluid Dynamics package (COMSOL Multiphysics to evaluate the homogeneity of fluid distribution in the microchannels. Four geometries were proposed and simulated in two and three dimensions to show that geometric details directly affect the distribution of velocity in the micro-heat exchanger channels. The simulation results were quite useful for the design of the microfluidic device. The micro-heat exchanger was then constructed using the LTCC technology and is composed of five thermal exchange plates in cross-flow arrangement and two connecting plates, with all plates stacked to form a device with external dimensions of 26 x 26 x 6 mm³.

  7. Analysis of the Technological Parameters of the Heat Exchanger in the Heating Pipe

    Directory of Open Access Journals (Sweden)

    Knyazev Vladimir

    2017-01-01

    Full Text Available The main purpose of this article is to analyze the selecting of technological parameters for the heat exchanger to improve the heat transfer and reduce the noise during operation in the heating pipe, which is used in the different systems of the planes and helicopters. In result of this study, the best technical parameters are found, considering different variations of deformation cutting heat exchanger pipes.

  8. Normative Stock Exchange and Speculative Activities: Critique and Empirical Verification

    OpenAIRE

    Amir Kia

    2001-01-01

    This study reviews Tag el-Dini's (1996) paper and raises the possibilities that his organizational models may create other kinds of inefficiency. Furthermore, using Canadian stock data I extended his study and found that excess speculative activities (bubbles) do not add any information to the stock markets. Consequently, according to our empirical evidence, in light of Tag el-Dini's view, to achieve an efficient and stable stock market a highly regulatory normative stock exchange is needed. ...

  9. Identity Orientation, Social Exchange, and Information Technology Use in Interorganizational Collaborations

    DEFF Research Database (Denmark)

    Gal, Uri; Jensen, Tina Blegind; Lyytinen, Kalle

    2014-01-01

    Advances in information technologies (IT) are creating unprecedented opportunities for interorganizational collaboration, particularly in large-scale distributed projects. The use of advanced IT in such projects can foster new forms of social exchange among organizations and change the way...... identity orientations. To address this gap, we conduct multiple case studies that describe the changing use of two-dimensional computer-aided design technology and new three-dimensional modeling technologies by a leading metal fabrication company in the architecture, engineering, and construction industry....... The case studies demonstrate that changes in the company's IT and the enactment of related IT affordances within variable interorganizational contexts enable new forms of social exchanges. These exchanges, in turn, provide the context for the rearticulation of the company's identity orientation. Based...

  10. Proton exchange membrane fuel cell technology for transportation applications

    Energy Technology Data Exchange (ETDEWEB)

    Swathirajan, S. [General Motors R& D Center, Warren, MI (United States)

    1996-04-01

    Proton Exchange Membrane (PEM) fuel cells are extremely promising as future power plants in the transportation sector to achieve an increase in energy efficiency and eliminate environmental pollution due to vehicles. GM is currently involved in a multiphase program with the US Department of Energy for developing a proof-of-concept hybrid vehicle based on a PEM fuel cell power plant and a methanol fuel processor. Other participants in the program are Los Alamos National Labs, Dow Chemical Co., Ballard Power Systems and DuPont Co., In the just completed phase 1 of the program, a 10 kW PEM fuel cell power plant was built and tested to demonstrate the feasibility of integrating a methanol fuel processor with a PEM fuel cell stack. However, the fuel cell power plant must overcome stiff technical and economic challenges before it can be commercialized for light duty vehicle applications. Progress achieved in phase I on the use of monolithic catalyst reactors in the fuel processor, managing CO impurity in the fuel cell stack, low-cost electrode-membrane assembles, and on the integration of the fuel processor with a Ballard PEM fuel cell stack will be presented.

  11. Advanced Heat/Mass Exchanger Technology for Geothermal and Solar Renewable Energy Systems

    Energy Technology Data Exchange (ETDEWEB)

    Greiner, Miles [Univ. of Nevada, Reno, NV (United States); Childress, Amy [Univ. of Nevada, Reno, NV (United States); Hiibel, Sage [Univ. of Nevada, Reno, NV (United States); Kim, Kwang [Univ. of Nevada, Reno, NV (United States); Park, Chanwoo [Univ. of Nevada, Reno, NV (United States); Wirtz, Richard [Univ. of Nevada, Reno, NV (United States)

    2014-12-16

    Northern Nevada has abundant geothermal and solar energy resources, and these renewable energy sources provide an ample opportunity to produce economically viable power. Heat/mass exchangers are essential components to any energy conversion system. Improvements in the heat/mass exchange process will lead to smaller, less costly (more efficient) systems. There is an emerging heat transfer technology, based on micro/nano/molecular-scale surface science that can be applied to heat/mass exchanger design. The objective is to develop and characterize unique coating materials, surface configurations and membranes capable of accommodating a 10-fold increase in heat/mass exchanger performance via phase change processes (boiling, condensation, etc.) and single phase convective heat/mass transfer.

  12. Active osmotic exchanger for advanced filtration at the nano scale

    Science.gov (United States)

    Marbach, Sophie; Bocquet, Lyderic

    2015-11-01

    One of the main functions of the kidney is to remove the waste products of an organism, mostly by excreting concentrated urea while reabsorbing water and other molecules. The human kidney is capable of recycling about 200 liters of water per day, at the relatively low cost of 0.5 kJ/L (standard dialysis requiring at least 150 kJ/L). Kidneys are constituted of millions of parallel filtration networks called nephrons. The nephrons of all mammalian kidneys present a specific loop geometry, the Loop of Henle, that is believed to play a key role in the urinary concentrating mechanism. One limb of the loop is permeable to water and the other contains sodium pumps that exchange with a common interstitium. In this work, we take inspiration from this osmotic exchanger design to propose new nanofiltration principles. We first establish simple analytical results to derive general operating principles, based on coupled water permeable pores and osmotic pumps. The best filtration geometry, in terms of power required for a given water recycling ratio, is comparable in many ways to the mammalian nephron. It is not only more efficient than traditional reverse osmosis systems, but can also work at much smaller pressures (of the order of the blood pressure, 0.13 bar, as compared to more than 30 bars for pressure-retarded osmosis systems). We anticipate that our proof of principle will be a starting point for the development of new filtration systems relying on the active osmotic exchanger principle.

  13. Activation of JNK by Epac is independent of its activity as a Rap guanine nucleotide exchanger.

    Science.gov (United States)

    Hochbaum, Daniel; Tanos, Tamara; Ribeiro-Neto, Fernando; Altschuler, Daniel; Coso, Omar A

    2003-09-05

    Guanine nucleotide exchange factors (GEFs) and their associated GTP-binding proteins (G-proteins) are key regulatory elements in the signal transduction machinery that relays information from the extracellular environment into specific intracellular responses. Among them, the MAPK cascades represent ubiquitous downstream effector pathways. We have previously described that, analogous to the Ras-dependent activation of the Erk-1/2 pathway, members of the Rho family of small G-proteins activate the JNK cascade when GTP is loaded by their corresponding GEFs. Searching for novel regulators of JNK activity we have identified Epac (exchange protein activated by cAMP) as a strong activator of JNK-1. Epac is a member of a growing family of GEFs that specifically display exchange activity on the Rap subfamily of Ras small G-proteins. We report here that while Epac activates the JNK severalfold, a constitutively active (G12V) mutant of Rap1b does not, suggesting that Rap-GTP is not sufficient to transduce Epac-dependent JNK activation. Moreover, Epac signaling to the JNKs was not blocked by inactivation of endogenous Rap, suggesting that Rap activation is not necessary for this response. Consistent with these observations, domain deletion mutant analysis shows that the catalytic GEF domain is dispensable for Epac-mediated activation of JNK. These studies identified a region overlapping the Ras exchange motif domain as critical for JNK activation. Consistent with this, an isolated Ras exchange motif domain from Epac is sufficient to activate JNK. We conclude that Epac signals to the JNK cascade through a new mechanism that does not involve its canonical catalytic action, i.e. Rap-specific GDP/GTP exchange. This represents not only a novel way to activate the JNKs but also a yet undescribed mechanism of downstream signaling by Epac.

  14. Frameworks and technologies for exchanging and sharing product life cycle knowledge

    NARCIS (Netherlands)

    Gerritsen, B.; Gielingh, W.; Dankwort, W.; Anderl, R.

    2011-01-01

    Frameworks and technologies for exchanging and sharing product life cycle knowledge (PLK) are discussed. A life cycle-centric knowledge management approach with stakeholders-in-the-loop allows for a life-long evaluation of the instantaneous performance and the consequential decision making about the

  15. Frameworks and technologies for exchanging and sharing product life cycle knowledge

    NARCIS (Netherlands)

    Gerritsen, B.; Gielingh, W.; Dankwort, W.; Anderl, R.

    2011-01-01

    Frameworks and technologies for exchanging and sharing product life cycle knowledge (PLK) are discussed. A life cycle-centric knowledge management approach with stakeholders-in-the-loop allows for a life-long evaluation of the instantaneous performance and the consequential decision making about the

  16. Mapping Knowledge Exchange in Early Modern Europe : Intellectual and Technological Geographies and Network Representations

    NARCIS (Netherlands)

    van den Heuvel, C.M.J.M.

    2015-01-01

    This paper discusses the development of digital intellectual and technological geographies showing spatial distributions of information and proposes to combine these with network representations of actors and documents relevant for the history knowledge exchange in Early Modern Europe. The amount of

  17. Structure and antibacterial activity of Ce~(3+) exchanged montmorillonites

    Institute of Scientific and Technical Information of China (English)

    OUYANG Yousheng; XIE Yushan; TAN Shaozao; SHI Qingshan; CHEN Yiben

    2009-01-01

    Four kinds of Ce~(3+) exchanged montmorillonites(Ce/MMTs) were prepared by an ion-exchange reaction, and characterized with energy dispersive X-ray analysis (EDX), X-ray difference (XRD), X-ray photoelectron spectroscopy (XPS) and scanning electron micros-copy (SEM). The surface properties and antibacterial activity of Ce/MMTs were also investigated. The chemical compositions of Ce/MMTs were determined, and the cerium of Ce/MMTs was confirmed to be present as trivalent cerium state. The d001 basal spacings of Ce/MMTs were enlarged with the enhancement of the cerium contents, and the particles were formed with irregular shape. On increasing the Ce con-tents of Ce/MMTs, the special surface areas were decreased, but the total pore volumes and the average pore sizes were increased. The anti-bacterial activity of Ce/MMTs is increased with increasing the cerium contents, and 1.5g/L of Ce/MMT-3 containing 11.46wt.% of curium could remove all the Staphylococcus aureus and more than 99.9% of the Escherichia coli within 24.0 h of contact. Moreover, Ce/MMTs dis-played bactericidal activity.

  18. Optical activity studies of hydrogen-deuterium exchange

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, L.J.

    1990-01-01

    The potassium complexes of racemic and optically active forms of 1,2-propanediaminetriacetatoacetic acid nickel-ate (II) were prepared stoichiometrically by two different experimental procedures. The complexes were characterized by UV-VIS absorption spectroscopy, infrared spectroscopy, and thermal analysis. Circular dichroism and optical rotatory dispersion values were obtained on the optically active complexes. TGA and IR spectroscopy techniques suggest that {Delta}-K (Ni(R ({minus})HPDTA)) H{sub 2}O (1)and {Lambda}-K (Ni(S (+)HPDTA)) H{sub 2}O (2) have different configurations in solution than in the solid state. Solid complexes of (1) are theorized to have the nickel (II) ion bound pentadentate to the PDTA ligand and unidentate to a water molecule. The free carboxyl arm of the PDTA ligand is protonated. Dissolution of the complexes results in rotational changes which occur with time. The rate of rotational change has been kinetically measured, which results in three pH dependent rate constants. An isotope effect for such reactions in H{sub 2}O and D{sub 2}O has been measured. The base-catalyzed hydrogen-deuterium exchange of the out-of-plane glycinate rings of (1) and (2) complexes has been determined for three of the four glycinate protons by ORD. The rate of hydrogen-deuterium exchange is extremely slow and consecutive proton exchanges are not independent of one another over sufficiently long periods, such that measurement of {alpha}{sub {infinity}} are calculated by three differing mathematical models and applied to the calculation of the hydrogen-deuterium rate constants.

  19. The impact of technological improvements on developing financial markets: The case of the Johannesburg Stock Exchange

    Directory of Open Access Journals (Sweden)

    Mehmet F. Dicle

    2013-07-01

    Full Text Available Can a significant technological improvement make an economically justifiable contribution to a financial market's development? The Johannesburg Stock Exchange (JSE incorporated the SETS system from the London Stock Exchange in 2002. It is certain that SETS is a technologically efficient trading system, and it would undoubtedly improve trading in the JSE. We test whether SETS represents a structural break by examining whether there was an increase in the JSE's liquidity, market efficiency and international integration after the introduction of SETS. While SETS is certainly a technological improvement with increased liquidity, it is not a sufficient factor to render it efficient. After the incorporation of SETS, the JSE has become more independent and it now offers better diversification opportunities for international investors.

  20. The mechanics of motorised momentum exchange tethers when applied to active debris removal from LEO

    Science.gov (United States)

    Caldecott, Ralph; Kamarulzaman, Dayangku N. S.; Kirrane, James P.; Cartmell, Matthew P.; Ganilova, Olga A.

    2014-12-01

    The concept of momentum exchange when applied to space tethers for propulsion is well established, and a considerable body of literature now exists on the on-orbit modelling, the dynamics, and also the control of a large range of tether system applications. The authors consider here a new application for the Motorised Momentum Exchange Tether by highlighting three key stages of development leading to a conceptualisation that can subsequently be developed into a technology for Active Debris Removal. The paper starts with a study of the on-orbit mechanics of a full sized motorised tether in which it is shown that a laden and therefore highly massasymmetrical tether can still be forced to spin, and certainly to librate, thereby confirming its possible usefulness for active debris removal (ADR). The second part of the paper concentrates on the modelling of the centripetal deployment of a symmetrical MMET in order to get it initialized for debris removal operations, and the third and final part of the paper provides an entry into scale modelling for low cost mission design and testing. It is shown that the motorised momentum exchange tether offers a potential solution to the removal of large pieces of orbital debris, and that dynamic methodologies can be implemented to in order to optimise the emergent design.

  1. Cosmetic devices based on active transdermal technologies.

    Science.gov (United States)

    Scott, Jessica A; Banga, Ajay K

    2015-01-01

    Active transdermal technology, commonly associated with drug delivery, has been used in recent years by the cosmetic industry for the aesthetic restoration of skin and delivery of cosmetic agents. In this article, we provide an overview of the skin's structure, various skin types, skin's self-repair mechanisms that are stimulated from the usage of cosmetic devices and discuss cosmetic applications. Summaries of the most common active transdermal technologies such as microneedles, iontophoresis, sonophoresis, lasers and microdermabrasion will be provided, in relation to the marketed cosmetic devices available that incorporate these technologies. Lastly, we cover combinations of active technologies that allow for more enhanced cosmetic results, and the current limitations of cosmetic devices.

  2. Technology Development Roadmap for the Advanced High Temperature Reactor Secondary Heat Exchanger

    Energy Technology Data Exchange (ETDEWEB)

    P. Sabharwall; M. McCllar; A. Siahpush; D. Clark; M. Patterson; J. Collins

    2012-09-01

    This Technology Development Roadmap (TDRM) presents the path forward for deploying large-scale molten salt secondary heat exchangers (MS-SHX) and recognizing the benefits of using molten salt as the heat transport medium for advanced high temperature reactors (AHTR). This TDRM will aid in the development and selection of the required heat exchanger for: power production (the first anticipated process heat application), hydrogen production, steam methane reforming, methanol to gasoline production, or ammonia production. This TDRM (a) establishes the current state of molten salt SHX technology readiness, (b) defines a path forward that systematically and effectively tests this technology to overcome areas of uncertainty, (c) demonstrates the achievement of an appropriate level of maturity prior to construction and plant operation, and (d) identifies issues and prioritizes future work for maturing the state of SHX technology. This study discusses the results of a preliminary design analysis of the SHX and explains the evaluation and selection methodology. An important engineering challenge will be to prevent the molten salt from freezing during normal and off-normal operations because of its high melting temperature (390°C for KF ZrF4). The efficient transfer of energy for industrial applications depends on the ability to incorporate cost-effective heat exchangers between the nuclear heat transport system and industrial process heat transport system. The need for efficiency, compactness, and safety challenge the capabilities of existing heat exchanger technology. The description of potential heat exchanger configurations or designs (such as printed circuit, spiral or helical coiled, ceramic, plate and fin, and plate type) were covered in an earlier report (Sabharwall et al. 2011). Significant future work, much of which is suggested in this report, is needed before the benefits and full potential of the AHTR can be realized. The execution of this TDRM will focuses

  3. Technological aspects of vegetable oils epoxidation in the presence of ion exchange resins: a review

    Directory of Open Access Journals (Sweden)

    Milchert Eugeniusz

    2016-09-01

    Full Text Available A review paper of the technology basics of vegetable oils epoxidation by means of peracetic or performic acid in the presence of acidic ion exchange resins has been presented. The influence of the following parameters: temperature, molar ratio of acetic acid and hydrogen peroxide to ethylenic unsaturation, catalyst loading, stirring intensity and the reaction time on a conversion of ethylenic unsaturation, the relative percentage conversion to oxirane and the iodine number was discussed. Optimal technological parameters, mechanism of epoxidation by carboxylic peracids and the possibilities of catalyst recycling have been also discussed. This review paper shows the application of epoxidized oils.

  4. Joint research and development and exchange of technology on toxic material emergency response between LLNL and ENEA. 1985 progress report

    Energy Technology Data Exchange (ETDEWEB)

    Dickerson, M.H.; Caracciolo, R.

    1986-01-31

    For the past six years, the US Department of Energy, LLNL, and the ENEA, Rome, Italy, have participated in cooperative studies for improving a systems approach to an emergency response following nuclear accidents. Technology exchange between LLNL and the ENEA was initially confined to the development, application, and evaluation of atmospheric transport and diffusion models. With the emergence of compatible hardware configurations between LLNL and ENEA, exchanges of technology and ideas for improving the development and implementation of systems are beginning to emerge. This report describes cooperative work that has occurred during the past three years, the present state of each system, and recommendations for future exchanges of technology.

  5. An Experience of the Transfer of Appropriate Technology from Fiji to Kenya; The 1987 ISIS-WICCE Exchange Programme on Women and Appropriate Technology.

    Science.gov (United States)

    Bolabola, Cema

    1987-01-01

    The author describes the 1987 exchange program "Women and Appropriate Technology." The program concentrated on appropriate technology in relation to rural women. She also describes a pilot appropriate technology project carried out in Kenya that involved the construction of three community buildings (a laundry and two bathrooms). (CH)

  6. The development of pedagogical content knowledge in science teachers: New opportunities through technology-mediated reflection and peer-exchange

    Science.gov (United States)

    Madeira, M. Cheryl-Ann

    This design-based research study investigates the development of pedagogical content knowledge among nine teacher-participants (N = 9) in three design phases. PCK is a particular type of teacher knowledge that addresses not only the teacher's understanding of the content to be instructed, but also ways of how to teach that content effectively. This knowledge has been well documented over several decades, and is seen as central to teacher expertise. However, its actual development has been difficult for researchers to investigate. This study offers a detailed perspective on how teachers developed PCK with their engagement in lesson planning and enactment of a project-based technology-enhanced lesson. The study includes two specific interventions designed to enhance teachers' development of PCK: (1) scaffolded reflection that occurs throughout the practices; and (2) peer-exchange of lesson plans, enactment ideas, and completed reflections. The findings demonstrate that teachers improve their planning and enactment of project-based technology-enhanced lessons with scaffolded reflection and peer exchange. Positive correlations were seen between teachers' engagement in the reflections and the quality of their lesson planning. Teachers who participated more deeply in the scaffolded reflections were able to understand how their lesson plans and enactment patterns fostered student understanding of relevant science concepts. Positive correlations were also seen between community influence and teacher lesson plans and enactment. Additionally, positive correlations were confirmed between teachers' level of participation in the peer exchange activities and the quality of their lesson planning and enactments. Teachers who contributed more deeply within the online and face-to-face peer community meetings benefited from the different perspectives of their peers about student learning and the best ways to succeed with project-based instruction. This study allowed some insight into

  7. Marshall Space Flight Center ECLSS technology activities

    Science.gov (United States)

    Wieland, Paul

    1990-01-01

    Viewgraphs on Environmental Control and Life Support System (ECLSS) technology activities are presented. Topics covered include: analytical development; ECLSS modeling approach; example of water reclamation modeling needs; and hardware development and testing.

  8. Technology transfer and technological learning through CERN's procurement activity

    CERN Document Server

    Autio, Erkko; Hameri, Ari-Pekka; CERN. Geneva

    2003-01-01

    This report analyses the technological learning and innovation benefits derived from CERN's procurement activity during the period 1997-2001. The base population of our study, the technology-intensive suppliers to CERN, consisted of 629 companies out of 6806 companies during the same period, representing 1197 MCHF in procurement. The main findings from the study can be summarized as follows: the various learning and innovation benefits (e.g., technological learning, organizational capability development, market learning) tend to occur together. Learning and innovation benefits appear to be regulated by the quality of the supplier's relationship with CERN: the greater the amount of social capital built into the relationship, the greater the learning and innovation benefits. Regardless of relationship quality, virtually all suppliers derived significant marketing reference benefits from CERN. Many corollary benefits are associated with procurement activity. As an example, as many as 38% of the respondents devel...

  9. NASDA's activities on vibration isolation technology

    Science.gov (United States)

    1992-01-01

    The National Space Development Agency's (NASDA) activities in providing various vibration isolation technologies for the Space Station Mission are covered in viewgraph form. Technologies covered include an active vibration isolation system for extra sensitive missions in the low frequency range, a passive damping system consisting of a damping rack for the reduction of resonance amplification, and an isolator for vibration isolation from low frequencies. Information is given in viewgraph form on the active vibration isolation concept, voice coil type electromagnetic suspension, a profile of an active vibration isolation system, a three degree of freedom ground experiment, and acceleration feedback.

  10. Semiautomatic exchanger of samples for carry out neutron activation analysis; Intercambiador semiautomatico de muestras para realizar analisis por activacion neutronica

    Energy Technology Data Exchange (ETDEWEB)

    Aguilar H, F.; Quintana C, G. [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico); Torres R, C. E.; Mejia J, J. O., E-mail: fortunato.aguilar@inin.gob.mx [Instituto Tecnologico de Toluca, Av. Tecnologico s/n, Ex-Rancho La Virgen, Metepec, Estado de Mexico (Mexico)

    2015-09-15

    In this paper the design methodology and implementation of a semiautomatic exchanger of samples for the Analysis Laboratory by Neutron Activation of the Reactor department is presented. Taking into account the antecedents, the necessities of improvement are described, as well as the equipment that previously contained the Laboratory. The project of the semiautomatic exchanger of samples was developed at Instituto Nacional de Investigaciones Nucleares, with its own technology to increase independence from commercial equipment. Each element of the semiautomatic exchanger of samples is described both in the design phase as construction. The achieved results are positive and encouraging for the fulfillment of the proposed objective that is to increase the capacity of the Laboratory. (Author)

  11. Activity targets for nanostructured platinum-group-metal-free catalysts in hydroxide exchange membrane fuel cells

    Science.gov (United States)

    Setzler, Brian P.; Zhuang, Zhongbin; Wittkopf, Jarrid A.; Yan, Yushan

    2016-12-01

    Fuel cells are the zero-emission automotive power source that best preserves the advantages of gasoline automobiles: low upfront cost, long driving range and fast refuelling. To make fuel-cell cars a reality, the US Department of Energy has set a fuel cell system cost target of US$30 kW-1 in the long-term, which equates to US$2,400 per vehicle, excluding several major powertrain components (in comparison, a basic, but complete, internal combustion engine system costs approximately US$3,000). To date, most research for automotive applications has focused on proton exchange membrane fuel cells (PEMFCs), because these systems have demonstrated the highest power density. Recently, however, an alternative technology, hydroxide exchange membrane fuel cells (HEMFCs), has gained significant attention, because of the possibility to use stable platinum-group-metal-free catalysts, with inherent, long-term cost advantages. In this Perspective, we discuss the cost profile of PEMFCs and the advantages offered by HEMFCs. In particular, we discuss catalyst development needs for HEMFCs and set catalyst activity targets to achieve performance parity with state-of-the-art automotive PEMFCs. Meeting these targets requires careful optimization of nanostructures to pack high surface areas into a small volume, while maintaining high area-specific activity and favourable pore-transport properties.

  12. Activity targets for nanostructured platinum-group-metal-free catalysts in hydroxide exchange membrane fuel cells.

    Science.gov (United States)

    Setzler, Brian P; Zhuang, Zhongbin; Wittkopf, Jarrid A; Yan, Yushan

    2016-12-06

    Fuel cells are the zero-emission automotive power source that best preserves the advantages of gasoline automobiles: low upfront cost, long driving range and fast refuelling. To make fuel-cell cars a reality, the US Department of Energy has set a fuel cell system cost target of US$30 kW(-1) in the long-term, which equates to US$2,400 per vehicle, excluding several major powertrain components (in comparison, a basic, but complete, internal combustion engine system costs approximately US$3,000). To date, most research for automotive applications has focused on proton exchange membrane fuel cells (PEMFCs), because these systems have demonstrated the highest power density. Recently, however, an alternative technology, hydroxide exchange membrane fuel cells (HEMFCs), has gained significant attention, because of the possibility to use stable platinum-group-metal-free catalysts, with inherent, long-term cost advantages. In this Perspective, we discuss the cost profile of PEMFCs and the advantages offered by HEMFCs. In particular, we discuss catalyst development needs for HEMFCs and set catalyst activity targets to achieve performance parity with state-of-the-art automotive PEMFCs. Meeting these targets requires careful optimization of nanostructures to pack high surface areas into a small volume, while maintaining high area-specific activity and favourable pore-transport properties.

  13. The geothermal potential of the Campania volcanic district and new heat exchanger technologies for exploitation of highly urbanised areas.

    Science.gov (United States)

    Carlino, S.; Somma, R.; Troiano, A.; Di Giuseppe, M. G.; Troise, C.; De Natale, G.

    2012-04-01

    The geothermal research in Campania region (Italy), started since the 1930, and continued until the '80 by the SAFEN, ENEL and AGIP companies. Such exploration activity highlighted that most of the volcanic districts of the Campania Region have a very high geothermal gradient and heat flow. In particular, inside the Campi Flegrei caldera and at Ischia island the geothermal gradient measured inside the deep wells reaches temperatures above 100° C between few tens and few hundreds of metres of depth, while the heat flow varies between 120-160 mWm-2 at Agnano and Mofete (Campi Flegrei main drill sites) to more than 500 mWm-2 at Ischia island (south-western sector). A general review of the available literature data (temperature at depth, stratigraphic sections, logs etc.) of the deep wells (down to 3 km b.s.l.) allowed us to quantify the geothermal potential (thermal and electric) of such district. The geothermal potential is about 6 GWy for the Campi Flegrei (Mofete and S. Vito sectors) and 11 GWy for the Ischia island (south-western sector) showing a geothermal reservoir with water and vapour dominant respectively. This results in strong potential interest for economic exploitation of the geothermal resource, both in the range of low-medium enthalpy at few hundreds of meters depth and of high enthalpy at depths of 1-2 km. In this study we try to model the effectiveness of new technologies of boreholes heat exchangers, which would allow to avoid fluid withdrawal, then strongly decreasing the environmental impact. The proposed technology consists of a double-pipe placed in a borehole heat exchange that can work coupled with an ORC. The two pipes, one inside the other, are located in the well in order to transfer the thermal energy to the working fluid during the descent in the external pipe and then go back through the internal pipe properly isolated. We propose a complete design of the borehole heat exchangers. The design activity is performed on a theoretical basis

  14. Design of Heat Exchanger Network for VCM Distillation Unit Using Pinch Technology

    Directory of Open Access Journals (Sweden)

    VISHAL G. BOKAN

    2015-06-01

    Full Text Available In process industries, heat exchanger networks represent an important part of the plant structure. The purpose of the networks is to maximize heat recovery, thereby lowering the overall plant costs. In process industries, during operation of any heat exchanger network (HEN, the major aim is to focus on the best performance of the network As in present condition of fuel crises is one of the major problem faced by many country & industrial utility is majorly depend on this. There is technique called process integration which is used for integrate heat within loop so optimize the given process and minimize the heating load and cooling load .In the present study of heat integration on VCM (vinyl chloride monomer distillation unit, Heat exchanger network (HEN is designed by using Aspen energy analyzer V8.0 software. This software implements a methodology for HEN synthesis with the use of pinch technology. Several heat integration networks are designed with different ΔT min and total annualized cost compared to obtain the optimal design. The network with a ΔT min of 90C is the most optimal where the largest energy savings are obtained with the appropriate use of utilities (Save 15.3764% for hot utilities and 47.52% for cold utilities compared with the current plant configuration. Percentage reduction in total operating cost is 18.333%. From calculation Payback Period for new design is 3.15 year. This save could be done through a plant revamp, with the addition of two heat exchangers. This improvement are done in the process associated with this technique are not due to the use of advance unit operation, but to the generation of heat integration scheme. The Pinch Design Method can be employed to give good designs in rapid time and with minimum data.

  15. Information Technologies In Transformation Of Marketing Activity

    OpenAIRE

    Nina Ilarionova

    2011-01-01

    The goal of the paper is to provide a comprehensive review of marketing issues influenced by information technologies. The macro-environment of marketing activity, strategic issues like marketing philosophy, marketing research and segmentation as well as marketing mix were analysed. The main findings are the following: IT advances do change every element of marketing activity of any company, offering both opportunities and threats.

  16. Technology Candidates for Air-to-Air and Air-to-Ground Data Exchange

    Science.gov (United States)

    Haynes, Brian D.

    2015-01-01

    Technology Candidates for Air-to-Air and Air-to-Ground Data Exchange is a two-year research effort to visualize the U. S. aviation industry at a point 50 years in the future, and to define potential communication solutions to meet those future data exchange needs. The research team, led by XCELAR, was tasked with identifying future National Airspace System (NAS) scenarios, determining requirements and functions (including gaps), investigating technical and business issues for air, ground, & air-to-ground interactions, and reporting on the results. The project was conducted under technical direction from NASA and in collaboration with XCELAR's partner, National Institute of Aerospace, and NASA technical representatives. Parallel efforts were initiated to define the information exchange functional needs of the future NAS, and specific communication link technologies to potentially serve those needs. Those efforts converged with the mapping of each identified future NAS function to potential enabling communication solutions; those solutions were then compared with, and ranked relative to, each other on a technical basis in a structured analysis process. The technical solutions emerging from that process were then assessed from a business case perspective to determine their viability from a real-world adoption and deployment standpoint. The results of that analysis produced a proposed set of future solutions and most promising candidate technologies. Gap analyses were conducted at two points in the process, the first examining technical factors, and the second as part of the business case analysis. In each case, no gaps or unmet needs were identified in applying the solutions evaluated to the requirements identified. The future communication solutions identified in the research comprise both specific link technologies and two enabling technologies that apply to most or all specific links. As a result, the research resulted in a new analysis approach, viewing the

  17. Robotics-Control Technology. Technology Learning Activity. Teacher Edition. Technology Education Series.

    Science.gov (United States)

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This document contains the materials required for presenting an 8-day competency-based technology learning activity (TLA) designed to introduce students in grades 6-10 to advances and career opportunities in the field of robotics-control technology. The guide uses hands-on exploratory experiences into which activities to help students develop…

  18. 77 FR 477 - Agency Information Collection Activities: Rules Relating to Regulation of Domestic Exchange...

    Science.gov (United States)

    2012-01-05

    ... COMMISSION Agency Information Collection Activities: Rules Relating to Regulation of Domestic Exchange-Traded... solicits comments on rules related to risk disclosure concerning exchange traded commodity options. DATES... introducing brokers: (1) To provide their customers with standard risk disclosure statements concerning the...

  19. 77 FR 5778 - Agency Information Collection Activities: Rules Relating to Regulation of Domestic Exchange...

    Science.gov (United States)

    2012-02-06

    ... COMMISSION Agency Information Collection Activities: Rules Relating to Regulation of Domestic Exchange-Traded... extension of the collection. The collection covers rules related to risk disclosure concerning exchange... INFORMATION: In the notice of Extension of an Existing Collection, FR Doc. 2011-33841, on page 477 in...

  20. Investing in International Information Exchange Activities to Improve the Safety, Cost Effectiveness and Schedule of Cleanup - 13281

    Energy Technology Data Exchange (ETDEWEB)

    Seed, Ian; James, Paula [Cogentus Consulting (United States); Mathieson, John [NDA United Kingdom (United Kingdom); Judd, Laurie [NuVision Engineering, Inc. (United States); Elmetti-Ramirez, Rosa; Han, Ana [US DOE (United States)

    2013-07-01

    With decreasing budgets and increasing pressure on completing cleanup missions as quickly, safely and cost-effectively as possible, there is significant benefit to be gained from collaboration and joint efforts between organizations facing similar issues. With this in mind, the US Department of Energy (DOE) and the UK Nuclear Decommissioning Authority (NDA) have formally agreed to share information on lessons learned on the development and application of new technologies and approaches to improve the safety, cost effectiveness and schedule of the cleanup legacy wastes. To facilitate information exchange a range of tools and methodologies were established. These included tacit knowledge exchange through facilitated meetings, conference calls and Site visits as well as explicit knowledge exchange through document sharing and newsletters. A DOE web-based portal has been established to capture these exchanges and add to them via discussion boards. The information exchange is operating at the Government-to-Government strategic level as well as at the Site Contractor level to address both technical and managerial topic areas. This effort has resulted in opening a dialogue and building working relationships. In some areas joint programs of work have been initiated thus saving resource and enabling the parties to leverage off one another activities. The potential benefits of high quality information exchange are significant, ranging from cost avoidance through identification of an approach to a problem that has been proven elsewhere to cost sharing and joint development of a new technology to address a common problem. The benefits in outcomes significantly outweigh the costs of the process. The applicability of the tools and methods along with the lessons learned regarding some key issues is of use to any organization that wants to improve value for money. In the waste management marketplace, there are a multitude of challenges being addressed by multiple organizations and

  1. NASA's Microgravity Technology Report: Summary of Activities 1997

    Science.gov (United States)

    Woodard, Dan

    1998-01-01

    The purpose of the 1997 NASA Microgravity Technology Report is to update the Microgravity Research Program's technology development policy and to present and assess current technology related activities and requirements identified within its research and technology disciplines.

  2. Design and technology parameters influence on durability for heat exchangers tube to tubesheet joints

    Science.gov (United States)

    Ripeanu, R. G.

    2017-02-01

    The main failures of heat exchangers are: corrosion of tubes and jacket, tubes blockage and failures of tube to tubesheet joints also by corrosion. The most critical zone is tube to tubesheet joints. Depending on types of tube to tubesheet joints, in order to better respect conditions of tension and compression, this paper analyses the tubesheet holes shapes, smooth and with a grove, on corrosion behavior. In the case of welding tubes with tubesheet, welding parameters modify corrosion behavior. Were realized welded joints by three welding regimes and tested at corrosion in two media, tap water and industrial water. Were tested also samples made of smooth tubes, finned tubes and tubes coated with a passive product as applied by a heat exchanger manufacturer. For all samples, the roughness parameters were measured, before and after the corrosion tests. The obtained corrosion rates show that stress values and their distribution along the joint modify the corrosion behavior. The optimum welding parameters were established in order to increase the joint durability. The paper has shown that passive product used is not proper chosen and the technology of obtaining rolled thread pipes diminishes tubes’ durability by increasing the corrosion rate.

  3. The strategic use of standardized information exchange technology in a university health system.

    Science.gov (United States)

    Cheng, Po-Hsun; Chen, Heng-Shuen; Lai, Feipei; Lai, Jin-Shin

    2010-04-01

    This article illustrates a Web-based health information system that is comprised of specific information exchange standards related to health information for healthcare services in National Taiwan University Health System. Through multidisciplinary teamwork, medical and informatics experts collaborated and studied on system scope definition, standard selection challenges, system implementation barriers, system management outcomes, and further expandability of other systems. After user requirement analysis and prototyping, from 2005 to 2008, an online clinical decision support system with multiple functions of reminding and information push was implemented. It was to replace its original legacy systems and serve among the main hospital and three branches of 180-200 clinics and 7,500-8,000 patient visits per day. To evaluate the effectiveness of this system, user surveys were performed, which revealed that the average score of user satisfaction increased from 2.80 to 3.18 on a 4-point scale. Among the items, especially e-learning for training service, courtesy communications for system requests, and courtesy communications for system operations showed statistically significant improvement. From this study, the authors concluded that standardized information exchange technologies can be used to create a brand new enterprise value and steadily obtain more competitive advantages for a prestige healthcare system.

  4. Air-Sea Exchange Of CO2: A Multi-Technology Approach

    Science.gov (United States)

    Tengberg, A.; Almroth, E.; Anderson, L.; Hall, P.; Hjalmarsson, S.; Lefevre, D.; Omstedt, A.; Rutgersson, A.; Sahlee, E.; Smedman, A.; Wesslander, K.

    2006-12-01

    We report on experiences and results from a multidisciplinary project in which we try to elucidate the complex processes involved in air-sea exchange of CO2. This study was performed in the Baltic Sea (off the Swedish island Gotland) and combined the following technologies: - Meteorological measurements of wind, turbulence, temperature, humidity, humidity flux, CO2 and CO2 flux at several levels from a fixed observation tower - Hourly PCO2 measurements with a moored automatic instrument - Collection of dissolved oxygen, temperature, salinity and turbidity data at different levels in the water column at 1-minute intervals - Daily light (PAR) and primary production measurements obtained with a moored automatic incubator - Daily primary production measurements using manual methods - Use of an acoustic current profiler to collect water column information on currents, turbulence, water level and waves - Repetitive water column profiles, from a ship, of dissolved inorganic carbon, oxygen, nutrients, alkalinity, pH, PAR, Chlorophyll A, salinity and temperature

  5. Influence of anodic surface treatment of activated carbon on adsorption and ion exchange properties

    Energy Technology Data Exchange (ETDEWEB)

    Park, S.J.; Kim, K.D.

    1999-10-01

    The effect of anodic surface treatment of activated carbon on adsorption and ion exchange characteristics was investigated in the condition of 35 wt% NaOH electrolyte for 60 s. The acid and base values were determined by a titration technique, and surface and pore structures were studied in terms of BET volumetric measurement with N{sub 2} adsorption. The ion exchange capacity of the anodized activated carbons was characterized by a dry weight capacity technique. It was observed that an increase in current intensity leads to an increase in the surface functional groups of activated carbons, resulting in increasing pH, acid-base values, and anion-cation exchange capacities, without significant change of surface and pore structures (i.e., specific surface area, total pore volume, micropore volume, and average pore diameter). Also, anodically treated activated carbons are more effectively evaluated on the base value or cation exchange capacity than on the oppose properties in this electrolytic system.

  6. PEE-PEO block copolymer exchange rate between micelles is detergent and temperature activated

    Science.gov (United States)

    Schantz, Allen; Saboe, Patrick; Lee, Hee-Young; Sines, Ian; Butler, Paul; Bishop, Kyle; Maranas, Janna; Kumar, Manish

    We examine the kinetics of polymer chain exchange between polymer/detergent micelles, a system relevant to the synthesis of protein-containing biomimetic membranes. Although chain exchange between polymer aggregates in water is too slow to observe, adding detergent allows us to determine chain exchange rates using time-resolved small-angle neutron scattering (TR-SANS). We examine a membrane-protein-relevant, vesicle-forming ultra-short polymer, Poly(ethyl ethylene)20-Poly(ethylene oxide)18 (PEE20-PEO18). PEE20-PEO18 is solubilized in mixed micelles with the membrane-protein-compatible non-ionic detergent octyl- β -D-glucoside (OG). We show that OG activates block copolymer exchange, and obtain rate constants at two detergent concentrations above the CMC (critical micellar concentration) of OG. We find that chain exchange increases two orders of magnitude when temperature increases from 308 to 338 K, and that even a 1 mg/mL increase in OG concentration leads to a noticeable increase in exchange rate. We also calculate the activation energy for chain exchange and find that it is much higher than for lipid exchange. These findings explain the need for high detergent concentration and/or temperature to synthesize densely packed polymer/protein membranes.

  7. Composition change of uranium perchlorates with organic ligands upon mechanochemical activation of exchange processes

    Science.gov (United States)

    Zazhogin, A. P.; Zazhogin, A. A.; Komyak, A. I.; Umreiko, D. S.

    2008-03-01

    Results of studies on the effect of mechanochemical activation of ligand exchange processes in uranyl perchlorate-dimethylsulfoxide are presented. Spectroscopic data show that mechanical activation of the exchange process in this system results in the replacement of H2O in the first coordination sphere of uranyl UO{2/2+} by DMSO to form nanocrystals with a defined ligand sphere. Possible factors governing the noted features are considered.

  8. Information technology -- Telecommunications and information exchange between systems -- Corporate telecommunication networks -- Signalling interworking between QSIG and H.323 -- Generic functional protocol for the support of supplementary services

    CERN Document Server

    International Organization for Standardization. Geneva

    2001-01-01

    Information technology -- Telecommunications and information exchange between systems -- Corporate telecommunication networks -- Signalling interworking between QSIG and H.323 -- Generic functional protocol for the support of supplementary services

  9. Information technology - Telecommunications and information exchange between systems - Private integrated services network - Specification, functional model and information flows - Call interception additional network feature

    CERN Document Server

    International Organization for Standardization. Geneva

    2003-01-01

    Information technology - Telecommunications and information exchange between systems - Private integrated services network - Specification, functional model and information flows - Call interception additional network feature

  10. Information technology - Telecommunications and information exchange between systems - Private integrated services network - Specification, functional model and information flows - Call priority interruption and call priority interruption protection supplementary services

    CERN Document Server

    International Organization for Standardization. Geneva

    2003-01-01

    Information technology - Telecommunications and information exchange between systems - Private integrated services network - Specification, functional model and information flows - Call priority interruption and call priority interruption protection supplementary services

  11. Information technology - Telecommunications and information exchange between systems - Private Integrated Services Network - Specification, functional model and information flows - Call transfer supplementary service

    CERN Document Server

    International Organization for Standardization. Geneva

    2003-01-01

    Information technology - Telecommunications and information exchange between systems - Private Integrated Services Network - Specification, functional model and information flows - Call transfer supplementary service

  12. Information technology - Telecommunications and information exchange between systems - Private integrated services network - Specification, functional model and information flows - Recall supplementary service

    CERN Document Server

    International Organization for Standardization. Geneva

    2003-01-01

    Information technology - Telecommunications and information exchange between systems - Private integrated services network - Specification, functional model and information flows - Recall supplementary service

  13. Information technology - Telecommunications and information exchange between systems - Elements of management information related to OSI transport layer standards; Amendment 1: NCMS Management; Technical Corrigendum 1

    CERN Document Server

    International Organization for Standardization. Geneva

    1994-01-01

    Information technology - Telecommunications and information exchange between systems - Elements of management information related to OSI transport layer standards; Amendment 1: NCMS Management; Technical Corrigendum 1

  14. Chinese Government Pursues Active Diffluence in Foreign Exchange Reserves

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ Chinese foreign exchange reserves have risen from US$ 145 billion in 1999 to US$ 1433.6 billion in 2007, increasing by almost ten fold in less than ten years, this can be attributed to the sustained and rapid growth of the Chinese economy, and the increasing amount of foreign direct investment(FDI). In the first three quarters of this year, the value of actually utilized FDI totaled US$ 47.2 billion,an increase of 10.87 percent compared with the same period last year.

  15. Role of nonlocal exchange correlation in activated adsorption

    DEFF Research Database (Denmark)

    Hammer, Bjørk; Jacobsen, Karsten Wedel; Nørskov, Jens Kehlet

    1993-01-01

    The barrier for dissociative adsorption of H-2 on Al(110) has been calculated within the generalized gradient approximation. A pronounced increase of the barrier height is found compared with what is calculated in the local density approximation (LDA). The apparent LDA underestimation...... of the barrier height is shown to be intimately linked with the LDA underbinding of core electrons and we suggest it to be a general phenomenon not limited to the particular nonlocal exchange-correlation approximation used or the particular system studied....

  16. The Analysis and Structuring of the Causes Impeding the Introduction of Advanced Technologies for Exchange Grain Trading

    Directory of Open Access Journals (Sweden)

    Vinnychenko Olena V

    2015-03-01

    Full Text Available In the article the main causes impeding the development and introduction of advanced technologies for grain trading on commodity exchanges in Ukraine have been identified and structured. The generalization of existing shortcomings in operation of the domestic commodity exchanges has served the basis for the model, within which there were built: a directed graph of correlations between the above mentioned shortcomings in the operation of exchanges, the matrix of dependency and reachability. The causes have been identified and structured, the main ones being determined, which, in turn, makes it possible to carry out the correct sequence of actions and emphasize the primary issues requiring priority solutions at making management decisions in order to promote the grain exchange market. The suggested approach clearly shows the correlation between the existing causes and sequence of their elimination.

  17. Evaluation of a hybrid ion exchange-catalyst treatment technology for nitrate removal from drinking water.

    Science.gov (United States)

    Bergquist, Allison M; Choe, Jong Kwon; Strathmann, Timothy J; Werth, Charles J

    2016-06-01

    Ion exchange (IX) is the most common approach to treating nitrate-contaminated drinking water sources, but the cost of salt to make regeneration brine, as well as the cost and environmental burden of waste brine disposal, are major disadvantages. A hybrid ion exchange-catalyst treatment system, in which waste brine is catalytically treated for reuse, shows promise for reducing costs and environmental burdens of the conventional IX system. An IX model with separate treatment and regeneration cycles was developed, and ion selectivity coefficients for each cycle were separately calibrated by fitting experimental data. Of note, selectivity coefficients for the regeneration cycle required fitting the second treatment cycle after incomplete resin regeneration. The calibrated and validated model was used to simulate many cycles of treatment and regeneration using the hybrid system. Simulated waste brines and a real brine obtained from a California utility were also evaluated for catalytic nitrate treatment in a packed-bed, flow-through column with 0.5 wt%Pd-0.05 wt%In/activated carbon support (PdIn/AC). Consistent nitrate removal and no apparent catalyst deactivation were observed over 23 d (synthetic brine) and 45 d (real waste brine) of continuous-flow treatment. Ion exchange and catalyst results were used to evaluate treatment of 1 billion gallons of nitrate-contaminated source water at a 0.5 MGD water treatment plant. Switching from a conventional IX system with a two bed volume regeneration to a hybrid system with the same regeneration length and sequencing batch catalytic reactor treatment would save 76% in salt cost. The results suggest the hybrid system has the potential to address the disadvantages of a conventional IX treatment systems. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. Natural clinoptilolite exchanged with iron: characterization and catalytic activity in nitrogen monoxide reduction

    Directory of Open Access Journals (Sweden)

    Daria Tito-Ferro

    2016-12-01

    Full Text Available The aim of this work was to characterize the natural clinoptilolite from Tasajeras deposit, Cuba, modified by hydrothermal ion-exchange with solutions of iron (II sulfate and iron (III nitrate in acid medium. Besides this, its catalytic activity to reduce nitrogen monoxide with carbon monoxide/propene in the presence of oxygen was evaluated. The characterization was performed by Mössbauer and UV-Vis diffuse reflectance spectroscopies and adsorption measurements. The obtained results lead to conclude that in exchanged samples, incorporated divalent and trivalent irons are found in octahedral coordination. Both irons should be mainly in cationic extra-framework positions inside clinoptilolite channels as charge compensating cations, and also as iron oxy-hydroxides resulting from limited hydrolysis of these cations. The iron (III exchanged samples has a larger amount of iron oxy-hydroxides agglomerates. The iron (II exchanged samples have additionally iron (II sulfate adsorbed. The catalytic activity in the nitrogen monoxide reduction is higher in the exchanged zeolites than starting. Among all samples, those exchanged of iron (II has the higher catalytic activity. This lead to outline that, main catalytically active centers are associated with divalent iron.

  19. Newly available technologies present expanding opportunities for scientific and technical information exchange

    Science.gov (United States)

    Tolzman, Jean M.

    1993-01-01

    The potential for expanded communication among researchers, scholars, and students is supported by growth in the capabilities for electronic communication as well as expanding access to various forms of electronic interchange and computing capabilities. Increased possibilities for information exchange, collegial dialogue, collaboration, and access to remote resources exist as high-speed networks, increasingly powerful workstations, and large, multi-user computational facilities are more frequently linked and more commonly available. Numerous writers speak of the telecommunications revolution and its impact on the development and dissemination of knowledge and learning. One author offers the phrase 'Scholarly skywriting' to represent a new form of scientific communication that he envisions using electronic networks. In the United States (U.S.), researchers associated with the National Science Foundation (NSF) are exploring 'nationwide collaboratories' and 'digital collaboration.' Research supported by the U.S. National Aeronautics and Space Administration (NASA) points to a future where workstations with built-in audio, video monitors, and screen sharing protocols are used to support collaborations with colleagues located throughout the world. Instruments and sensors located worldwide will produce data streams that will be brought together, analyzed, and distributed as new findings. Researchers will have access to machines that can supply domain-specific information in addition to locator and directory assistance. New forms of electronic journals will emerge and provide opportunities for researchers and scientists to exchange information electronically and interactively in a range of structures and formats. Ultimately, the wide-scale use of these technologies in the dissemination of research results and the stimulation of collegial dialogue will change the way we represent and express our knowledge of the world. A new paradigm will evolve--perhaps a truly worldwide

  20. A Minimal Rac Activation Domain in the Unconventional Guanine Nucleotide Exchange Factor Dock180†

    OpenAIRE

    Xin WU; Ramachandran, Sekar; Cerione, Richard A.; Erickson, Jon W.

    2011-01-01

    Guanine nucleotide exchange factors (GEFs) activate Rho GTPases by catalyzing the exchange of bound GDP for GTP, thereby resulting in downstream effector recognition. Two metazoan families of GEFs have been described: Dbl-GEF family members that share conserved Dbl homology (DH) and Pleckstrin homology (PH) domains and the more recently described Dock180 family members that share little sequence homology with the Dbl family and are characterized by conserved Dock homology regions 1 and 2 (DHR...

  1. Heat-Activated Effect of Exchange Coupling Between Two Ferromagnets Separated by an Amorphous Semiconducting Barrier

    Institute of Scientific and Technical Information of China (English)

    肖明文; 李正中; 许望

    2002-01-01

    We try to extend our previous zero-temperature tunnelling theory for the exchange coupling between two ferromagnets separated by an amorphous semiconducting barrier to the case of finite temperature. The result exhibits that the tunnelling electrons can absorb or emit phonons when they tunnel through the amorphous barrier at finite temperatures so that the interlayer exchange coupling is heat activated. This agrees with the experiments.

  2. Horizontal exchange of information - institutional impact on entrepreneurial activity

    Directory of Open Access Journals (Sweden)

    Patricia Kotnik

    2012-11-01

    Full Text Available Providing incentives for technological innovation (spurring the generation and utilisation of productive information, entrepreneurship and co-operation, and deterring opportunism are of the utmost importance for economic growth and maximisation of social welfare. This paper offers a legal evaluation of the optimal entrepreneurial incentive mechanisms under current anti-competitive enforcement practices and provides a legal and economic analysis of its economic and business impacts

  3. Guidance manual for conducting technology demonstration activities

    Energy Technology Data Exchange (ETDEWEB)

    Jolley, Robert L.; Morris, Michael I.; Singh, Suman P.N.

    1991-12-01

    This demonstration guidance manual has been prepared to assist Martin Marietta Energy Systems, Inc. (Energy Systems), staff in conducting demonstrations. It is prepared in checklist style to facilitate its use and assumes that Energy Systems personnel have project management responsibility. In addition to a detailed step-by-step listing of procedural considerations, a general checklist, logic flow diagram, and several examples of necessary plans are included to assist the user in developing an understanding of the many complex activities required to manage technology demonstrations. Demonstrations are pilot-scale applications of often innovative technologies to determine the commercial viability of the technologies to perform their designed function. Demonstrations are generally conducted on well-defined problems for which existing technologies or processes are less than satisfactory in terms of effectiveness, cost, and/or regulatory compliance. Critically important issues in demonstration management include, but are not limited to, such factors as communications with line and matrix management and with the US Department of Energy (DOE) and Energy Systems staff responsible for management oversight, budgetary and schedule requirements, regulatory compliance, and safety.

  4. Anti-inflammatory activity of human IgG4 antibodies by dynamic Fab arm exchange.

    Science.gov (United States)

    van der Neut Kolfschoten, Marijn; Schuurman, Janine; Losen, Mario; Bleeker, Wim K; Martínez-Martínez, Pilar; Vermeulen, Ellen; den Bleker, Tamara H; Wiegman, Luus; Vink, Tom; Aarden, Lucien A; De Baets, Marc H; van de Winkel, Jan G J; Aalberse, Rob C; Parren, Paul W H I

    2007-09-14

    Antibodies play a central role in immunity by forming an interface with the innate immune system and, typically, mediate proinflammatory activity. We describe a novel posttranslational modification that leads to anti-inflammatory activity of antibodies of immunoglobulin G, isotype 4 (IgG4). IgG4 antibodies are dynamic molecules that exchange Fab arms by swapping a heavy chain and attached light chain (half-molecule) with a heavy-light chain pair from another molecule, which results in bispecific antibodies. Mutagenesis studies revealed that the third constant domain is critical for this activity. The impact of IgG4 Fab arm exchange was confirmed in vivo in a rhesus monkey model with experimental autoimmune myasthenia gravis. IgG4 Fab arm exchange is suggested to be an important biological mechanism that provides the basis for the anti-inflammatory activity attributed to IgG4 antibodies.

  5. Linking Employee Development Activity, Social Exchange and Organizational Citizenship Behavior

    Science.gov (United States)

    Pierce, Heather R.; Maurer, Todd J.

    2009-01-01

    The authors examined "perceived beneficiary" of employee development (self, organization) for relationships with employee development activity. Perceived organizational support served as a moderator. The authors conclude that employees may engage in development activities to partly benefit their organization to the extent that a positive exchange…

  6. Linking Employee Development Activity, Social Exchange and Organizational Citizenship Behavior

    Science.gov (United States)

    Pierce, Heather R.; Maurer, Todd J.

    2009-01-01

    The authors examined "perceived beneficiary" of employee development (self, organization) for relationships with employee development activity. Perceived organizational support served as a moderator. The authors conclude that employees may engage in development activities to partly benefit their organization to the extent that a positive exchange…

  7. PAK1 negatively regulates the activity of the Rho exchange factor NET1.

    Science.gov (United States)

    Alberts, Arthur S; Qin, Huajun; Carr, Heather S; Frost, Jeffrey A

    2005-04-01

    Rho family small G-protein activity is controlled by guanine nucleotide exchange factors that stimulate the release of GDP, thus allowing GTP binding. Once activated, Rho proteins control cell signaling through interactions with downstream effector proteins, leading to changes in cytoskeletal organization and gene expression. The ability of Rho family members to modulate the activity of other Rho proteins is also intrinsic to these processes. In this work we show that the Rac/Cdc42hs-regulated protein kinase PAK1 down-regulates the activity of the RhoA-specific guanine nucleotide exchange factor NET1. Specifically, PAK1 phosphorylates NET1 on three sites in vitro: serines 152, 153, and 538. Replacement of serines 152 and 153 with glutamate residues down-regulates the activity of NET1 as an exchange factor in vitro and its ability to stimulate actin stress fiber formation in cells. Using a phospho-specific antibody that recognizes NET1 phosphorylated on serine 152, we show that PAK1 phosphorylates NET1 on this site in cells and that Rac1 stimulates serine 152 phosphorylation in a PAK1-dependent manner. Furthermore, coexpression of constitutively active PAK1 inhibits the ability of NET1 to stimulate actin polymerization only when serines 152 and 153 are present. These data provide a novel mechanism for the control of RhoA activity by Rac1 through the PAK-dependent phosphorylation of NET1 to reduce its activity as a guanine nucleotide exchange factor.

  8. International Day of Peace——China-Finland Friendly Exchange Activity Held

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    <正>September 21 is the UN-designated International Day of Peace. One of the activities in China to mark this year’s observation was a China-Finland friendly exchange activity held at the Beijing residence of the Finnish ambassador.

  9. Oxygen exchange at gas/oxide interfaces: how the apparent activation energy of the surface exchange coefficient depends on the kinetic regime.

    Science.gov (United States)

    Fielitz, Peter; Borchardt, Günter

    2016-08-10

    In the dedicated literature the oxygen surface exchange coefficient KO and the equilibrium oxygen exchange rate [Fraktur R] are considered to be directly proportional to each other regardless of the experimental circumstances. Recent experimental observations, however, contradict the consequences of this assumption. Most surprising is the finding that the apparent activation energy of KO depends dramatically on the kinetic regime in which it has been determined, i.e. surface exchange controlled vs. mixed or diffusion controlled. This work demonstrates how the diffusion boundary condition at the gas/solid interface inevitably entails a correlation between the oxygen surface exchange coefficient KO and the oxygen self-diffusion coefficient DO in the bulk ("on top" of the correlation between KO and [Fraktur R] for the pure surface exchange regime). The model can thus quantitatively explain the range of apparent activation energies measured in the different regimes: in the surface exchange regime the apparent activation energy only contains the contribution of the equilibrium exchange rate, whereas in the mixed or in the diffusion controlled regime the contribution of the oxygen self-diffusivity has also to be taken into account, which may yield significantly higher apparent activation energies and simultaneously quantifies the correlation KO ∝ DO(1/2) observed for a large number of oxides in the mixed or diffusion controlled regime, respectively.

  10. A Part of Wine-making Scientific&Technological Exchange History Between China and Foreign Countries:FANG Xinfang's Academic Activities in His Study Period Abroad%中外酿酒科技交流史的一页——方心芳留学时期的活动与学术

    Institute of Scientific and Technical Information of China (English)

    朱更勇; 郭旭

    2015-01-01

    1935—1937年间,方心芳留学欧洲.在出国留学前,方心芳在传统发酵产品研究方面已有所成就.在国外的这段时间里,方心芳与外国专家交流高粱酒改良方法;四处访学,增广学识;撰述不辍,促进交流;搜集菌种,互通有无;关心社会,心系祖国.国外留学是其学术生涯中承前启后的关键阶段,是中外酿酒科技交流史上值得书写的一页.%FANG Xinfang studied in Europe in 1935-1937. Before he studied abroad, FANG Xinfang had made great accomplishments in the field of traditional fermentation products. During his stay in Europe, he exchanged sorghum liquor improvement methods with foreign experts, visited famous wine-making experts, wrote academic papers, collected bacteria strains, and cared a lot about his homeland. His studying period abroad is a key stage in his academic career, also a notable part of wine-making scientific&technological exchange history.(Trans. by YUE Yang)

  11. Active heat exchange system development for latent heat thermal energy storage

    Science.gov (United States)

    Lefrois, R. T.; Mathur, A. K.

    1980-04-01

    Five tasks to select, design, fabricate, test and evaluate candidate active heat exchanger modules for future applications to solar and conventional utility power plants were discussed. Alternative mechanizations of active heat exchange concepts were analyzed for use with heat of fusion phase change materials (PCMs) in the temperature range of 250 to 350 C. Twenty-six heat exchange concepts were reviewed, and eight were selected for detailed assessment. Two candidates were selected for small-scale experimentation: a coated tube and shell heat exchanger and a direct contact reflux boiler. A dilute eutectic mixture of sodium nitrate and sodium hydroxide was selected as the PCM from over 50 candidate inorganic salt mixtures. Based on a salt screening process, eight major component salts were selected initially for further evaluation. The most attractive major components in the temperature range of 250 to 350 C appeared to be NaNO3, NaNO2, and NaOH. Sketches of the two active heat exchange concepts selected for test are given.

  12. Active heat exchange system development for latent heat thermal energy storage

    Science.gov (United States)

    Lefrois, R. T.; Mathur, A. K.

    1980-01-01

    Five tasks to select, design, fabricate, test and evaluate candidate active heat exchanger modules for future applications to solar and conventional utility power plants were discussed. Alternative mechanizations of active heat exchange concepts were analyzed for use with heat of fusion phase change materials (PCMs) in the temperature range of 250 to 350 C. Twenty-six heat exchange concepts were reviewed, and eight were selected for detailed assessment. Two candidates were selected for small-scale experimentation: a coated tube and shell heat exchanger and a direct contact reflux boiler. A dilute eutectic mixture of sodium nitrate and sodium hydroxide was selected as the PCM from over 50 candidate inorganic salt mixtures. Based on a salt screening process, eight major component salts were selected initially for further evaluation. The most attractive major components in the temperature range of 250 to 350 C appeared to be NaNO3, NaNO2, and NaOH. Sketches of the two active heat exchange concepts selected for test are given.

  13. Synthesis, characterization and antimicrobial activity of alkaline ion-exchanged ZnO/bentonite nanocomposites

    Institute of Scientific and Technical Information of China (English)

    Hamideh Pouraboulghasem; Mohammad Ghorbanpour; Razieh Shayegh; Samaneh Lotfiman

    2016-01-01

    Nanocomposites of zinc/bentonite clay were synthesized for use as an antibacterial material by a quick and simple alkaline ion exchange method. The synthesis of zinc doped bentonite nanocomposite was accomplished by placing bentonite in a melting bath of ZnSO4 for 10, 20, 40, 60 and 90 min. The complexes were characterized by XRD, SEM and DRS. XRD analyses and SEM observations confirmed the diffusion of zinc to the clay surfaces. Antibacterial activity tests againstEscherichia coli showed that bentonite did not present any antibacterial properties, but after alkaline ion exchange treatment, inhibition was noted. The highest antibacterial activity was observed with ZnO/bentonite composite alkaline ion exchange for 60 and 90 min. Interestingly, the leaching test indicated that ZnO/bentonite did not present any risk for drinking water treatment.

  14. Intensification of ammonia removal from waste water in biologically active zeolitic ion exchange columns.

    Science.gov (United States)

    Almutairi, Azel; Weatherley, Laurence R

    2015-09-01

    The use of nitrification filters for the removal of ammonium ion from waste-water is an established technology deployed extensively in municipal water treatment, in industrial water treatment and in applications such as fish farming. The process involves the development of immobilized bacterial films on a solid packing support, which is designed to provide a suitable host for the film, and allow supply of oxygen to promote aerobic action. Removal of ammonia and nitrite is increasingly necessary to meet drinking water and discharge standards being applied in the US, Europe and other places. Ion-exchange techniques are also effective for removal of ammonia (as the ammonium ion) from waste water and have the advantage of fast start-up times compared to biological filtration which in some cases may take several weeks to be fully operational. Here we explore the performance of ion exchange columns in which nitrifying bacteria are cultivated, with the goal of a "combined" process involving simultaneous ion-exchange and nitrification, intensified by in-situ aeration with a novel membrane module. There were three experimental goals. Firstly, ion exchange zeolites were characterized and prepared for comparative column breakthrough studies for ammonia removal. Secondly effective in-situ aeration for promotion of nitrifying bacterial growth was studied using a number of different membranes including polyethersulfone (PES), polypropylene (PP), nylon, and polytetra-fluoroethylene (PTFE). Thirdly the breakthrough performance of ion exchange columns filled with zeolite in the presence of aeration and in the presence of nitrifying bacteria was determined to establish the influence of biomass, and aeration upon breakthrough during ammonium ion uptake. The methodology adopted included screening of two types of the naturally occuring zeolite clinoptilolite for effective ammonia removal in continuous ion-exchange columns. Next, the performance of fixed beds of clinoptilolite in the

  15. Ion Exchange Technology Development in Support of the Urine Processor Assembly Precipitation Prevention Project for the International Space Station

    Science.gov (United States)

    Mitchell, Julie L.; Broyan, James L.; Pickering, Karen D.; Adam, Niklas; Casteel, Michael; Callahan, Michael; Carrier, Chris

    2012-01-01

    In support of the Urine Processor Assembly Precipitation Prevention Project (UPA PPP), multiple technologies were explored to prevent CaSO4 2H2O (gypsum) precipitation during the on-orbit distillation process. Gypsum precipitation currently limits the water recovery rate onboard the International Space Station (ISS) to 70% versus the planned 85% target water recovery rate. Due to its ability to remove calcium cations in pretreated augmented urine (PTAU), ion exchange was selected as one of the technologies for further development by the PPP team. A total of 13 ion exchange resins were evaluated in various equilibrium and dynamic column tests with solutions of dissolved gypsum, urine ersatz, PTAU, and PTAU brine at 85% water recovery. While initial evaluations indicated that the Purolite SST60 resin had the highest calcium capacity in PTAU (0.30 meq/mL average), later tests showed that the Dowex G26 and Amberlite FPC12H resins had the highest capacity (0.5 meq/mL average). Testing at the Marshall Spaceflight Center (MSFC) integrates the ion exchange technology with a UPA ground article under flight-like pulsed flow conditions with PTAU. To date, no gypsum precipitation has taken place in any of the initial evaluations.

  16. Calcium Activities During Different Ion Exchange Separation Procedures

    Science.gov (United States)

    Zhang, Z.; Zhu, H.; Liu, Y.; Liu, F.; Zhang, C.; Sun, W.

    2014-12-01

    Calcium is a major element and participates in many geological processes. Investigations on stable calcium isotopic compositions of natural geological samples provide a great powerful tool to understand all kinds of those geological processes from a view of the field of isotope geochemistry. With the development of modern instruments and chemical separation techniques, calcium isotopic compositions could be determined even more precisely if the column chemistry brings no deviation. Usually, Calcium is separated from matrix elements using cation resin columns and the related chemical separation techniques seem to be robust. However, more detailed work still need to be done on matrix effects and calcium isotopic fractionations on column chemistry or during elution processes. If calcium is run on TIMS instruments, the interference effect could be lower and easier controlled, thus, the requirement to the chemistry is relatively not critic, but calcium fractionation on filaments could be much difficult to monitor. If calcium is run on MC-ICP-MS instruments, the interference effect could be huge and is really difficult to be recognized and subtracted, the requirement to the chemistry is much more critical in order to get a real result of the sample, but the instrument fractionation could be easier to monitor. Here we investigate calcium activities on several kinds of cation resins under different column/acid conditions. We seek to find a good balance between recovery and interference effect on column chemistry and are intend to set up a better chemical separation procedure to satisfy the instrument requirements for calcium. In addition, Calcium isotopic fractionation on column will also be discussed further here based on our previous and ongoing results.

  17. International exchange project for the engineer exchange project (in coal mine technology area) in fiscal 1998. Overseas workshop; 1998 nendo gijutsusha koryu jigyo (tanko gijutsu bun'ya) kokusai koryu jigyo. Kaigai workshop

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    The international exchange project for the engineer exchange project (in coal mine technology area) in fiscal 1998, the 'Overseas workshop' has performed exchange in technologies with Australian coal mine engineers. The project refers to the Australian technological levels and needs in coal production, safety control and environment, as well as transfer of the Japanese coal mine technologies. This report summarizes the result of a survey on the engineer exchange project in the coal mine technology area and the possibility of joint researches. The 'overseas workshop' was held in November 1998 for two days in Brisbane City in QLD Province as the 'Japan-Australia coal technology workshop'. The 'Japan-Australia coal technology workshop' gave lectures in five sessions (the basic lecture, Japan-Australia high-speed excavation project, coal mine gas control project, exploration and resources, and development and experience of Japan). It also discussed two themes (mine safety management and rules, and greenhouse effect gases and coal mining). Two coal mines were visited thereafter to deepen the exchange with the Australian coal mine engineers. (NEDO)

  18. Amine-functionalized, silver-exchanged zeolite NaY: Preparation, characterization and antibacterial activity

    Energy Technology Data Exchange (ETDEWEB)

    Hanim, Siti Aishah Mohd; Malek, Nik Ahmad Nizam Nik, E-mail: niknizam@fbb.utm.my; Ibrahim, Zaharah

    2016-01-01

    Graphical abstract: - Highlights: • Functionalization of Ag-exchanged zeolite NaY with 3-aminopropyltriethoxysilane APTES (ZSA) as antibacterial agent. • Antibacterial assay of ZSA was performed against Escherichia coli ATCC11229 and Staphylococcus aureus ATCC6538. • Functionalization of Ag-exchanged zeolite NaY with APTES significantly increased the antibacterial agent. • Different mechanisms of bacterial death were suggested for each bacteria type by the functionalized Ag-exchanged zeolite NaY. - Abstract: Amine-functionalized, silver-exchanged zeolite NaY (ZSA) were prepared with three different concentrations of 3-aminopropyltriethoxysilane (APTES) (0.01, 0.20 and 0.40 M) and four different concentrations of silver ions (25%, 50%, 100% and 200% from zeolite cation exchange capacity (CEC)). The samples were characterized by Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), energy-dispersive X-ray (EDX), surface area analysis, thermogravimetric analysis (TGA) and zeta potential (ZP) analysis. The FTIR results indicated that the zeolite was functionalized by APTES and that the intensity of the peaks corresponding to APTES increased as the concentration of APTES used was increased. The antibacterial activities of the silver-exchanged zeolite NaY (ZS) and ZSA were studied against Escherichia coli ATCC11229 and Staphylococcus aureus ATCC6538 using the disc diffusion technique (DDT) and minimum inhibitory concentration (MIC). The antibacterial activity of ZSA increased with the increase in APTES on ZS, and E. coli was more susceptible towards the sample compared to S. aureus. The FESEM micrographs of the bacteria after contact with the ZSA suggested different mechanisms of bacterial death for these two bacteria due to exposure to the studied sample. The functionalization of ZS with APTES improved the antibacterial activity of the silver-zeolite, depending on the concentration of silver

  19. NASA's Microgravity Technology Report, 1996: Summary of Activities

    Science.gov (United States)

    Kierk, Isabella

    1996-01-01

    This report covers technology development and technology transfer activities within the Microgravity Science Research Programs during FY 1996. It also describes the recent major tasks under the Advanced Technology Development (ATD) Program and identifies current technology requirements. This document is consistent with NASA,s Enteprise for the Human Exploration and development of Space (HEDS) Strategic Plan. This annual update reflects changes in the Microgravity Science Research Program's new technology activities and requirements. Appendix A. FY 1996 Advanced Technology Development. Program and Project Descriptions. Appendix B. Technology Development.

  20. Expectations and realities in the nuclear technology exchanges with the USSR

    Energy Technology Data Exchange (ETDEWEB)

    Lewin, J.

    1980-01-01

    A nontechnical, subjective account is given of some of the experiences and personal encounters in the US-USSR technical exchange visit programs. Some notes are given on the growth of nuclear power in the two countries. (DLC)

  1. Bactericidal and ammonia removal activity of silver ion-exchanged zeolite.

    Science.gov (United States)

    Krishnani, K K; Zhang, Yu; Xiong, Laj; Yan, Yushan; Boopathy, Raj; Mulchandani, Ashok

    2012-08-01

    The antimicrobial activity of silver-zeolite against Escherichia coli, Vibrio harveyi, Vibrio cholerae and Vibrio parahaemolyticus was examined in liquid medium and agar well diffusion assays. The minimum inhibitory concentration for silver ion-exchanged zeolite against E. coli and V. harveyi was 40 μg/ml, and 50-60 μg/ml for V. cholerae and V. parahaemolyticus. The diameter of the inhibition zones for E. coli, V. harveyi, V. cholerae and V. parahaemolyticus, respectively, increased from 0.5 to 2.3 cm, 0.6 to 2.4 cm, 0.3 to 1.65 cm and 0.3 to 1.7 cm with increasing concentrations of silver ion-exchanged zeolite from 10 to 400 μg. Silver-zeolite removed 20-37% ammonia from aqueous solutions. This study suggests that silver ion-exchanged zeolite could impact disease and environmental management in shrimp aquaculture.

  2. Activity systems modeling as a theoretical lens for social exchange studies

    Directory of Open Access Journals (Sweden)

    Ernest Jones

    2016-01-01

    Full Text Available The social exchange perspective seeks to acknowledge, understand and predict the dynamics of social interactions. Empirical research involving social exchange constructs have grown to be highly technical including confirmatory factor analysis to assess construct distinctiveness and structural equation modeling to assess construct causality. Each study seemingly strives to assess how underlying social exchange theoretic constructs interrelate. Yet despite this methodological depth and resultant explanatory and predictive power, a significant number of studies report findings that, once synthesized, suggest an underlying persistent threat of conceptual or construct validity brought about by a search for epistemological parsimony. Further, it is argued that a methodological approach that embraces inherent complexity such as activity systems modeling facilitates the search for simplified models while not ignoring contextual factors.

  3. The effect of monetary policy of Central Bank on activities of Tehran Stock Exchange

    Directory of Open Access Journals (Sweden)

    Hossein Vazifehdust

    2013-08-01

    Full Text Available This paper examines the relationship between monetary policy and activity of the Tehran Stock Exchange. The statistical population of the research consists of all companies listed in Tehran Stock Exchange and central bank monetary policy variables including time series generated by the central bank seasonally. For the purpose of data analysis, econometric autoregressive system models, and two-stage ADF regression with unit roots test, co-integration and reliability were used to determine level of effect and type of effect of the four components of monetary policy on exchange activity. The results of this study show that there is a strong relation between share price index and monetary policy variables and between monetary policy variables and trading volume. However, the relation between monetary policy variables and cash yield index was not so strong, but monetary policy variables’ effect on stock exchange activity was acceptable considering strong relation between the two first variables. It is suggested that if this work is done using non-linear models, it will yield better results.

  4. Homologous DNA strand exchange activity of the human mitochondrial DNA helicase TWINKLE

    OpenAIRE

    Sen, Doyel; Patel, Gayatri; Smita S Patel

    2016-01-01

    A crucial component of the human mitochondrial DNA replisome is the ring-shaped helicase TWINKLE—a phage T7-gene 4-like protein expressed in the nucleus and localized in the human mitochondria. Our previous studies showed that despite being a helicase, TWINKLE has unique DNA annealing activity. At the time, the implications of DNA annealing by TWINKLE were unclear. Herein, we report that TWINKLE uses DNA annealing function to actively catalyze strand-exchange reaction between the unwinding su...

  5. Measuring Information Asymmetry in Large Active Firms on the Tehran Stock Exchange

    Directory of Open Access Journals (Sweden)

    Shamsoddini Mostafa

    2016-11-01

    Full Text Available In financial markets, transparency of financial information is one of the most effective variables of investment strategies. Information asymmetry can seriously affect firm performance on the stock exchange and firms with a poor informational environment can lose the interest of investors. Reducing information asymmetry can have an important effect on firm performance on the stock exchange. Firms may lack a clear informational environment in the market because of the emerging conditions governing the Tehran Stock Exchange. Because larger and more active firms on the Tehran Stock Exchange provide more information, measuring the informational environment of these firms provides an overview of information asymmetry. The present study calculated the information asymmetry in these firms using the PIN and FE indices. The inconsistent results provided by these indices prompted the authors to offer a new index that is a composite of the PIN and FE that can better explain information asymmetry in developing market such as Asian stock markets. The results show that the new composite index, by using the mechanisms of the PIN and FE indices, provides a better outcome. The new composite index shows that the Tosee Melli Inv (TMEL1, Mobarakeh Steel (FOLD1, Iran Mobil Tele (HMRZ1, Saipa (SIPA1 and I.N.C. Ind. (MSMI1 firms have a better informational environment on the Tehran Stock Exchange.

  6. FSA future directions: FSA technology activities in FY86

    Science.gov (United States)

    Leipold, M. H.

    1985-01-01

    The silicon material, advanced silicon sheet, device research, and process research activities are explained. There will be no new initiatives. Many activities are targeted for completion and the emphasis will then be on technology transfer. Industrial development of the fluidized-bed reactor (FBR) deposition technology is proceeding. Technology transfer and industry funding of sheet development are continuing.

  7. Engineer exchanging project on coal mine technology field in fiscal 1999. International information exchanging project (the overseas workshop in Vietnam); 1999 nendo gijutsusha koryu jigyo (tanko gijutsu bun'ya) kokusai koryu jigyo. Kaigai workshop (Vietnam)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    Technical information exchange was performed with Vietnamese engineers related to coal mine technologies through the overseas workshop and the technical tour. At the same time, investigations were executed on the production technology levels and needs in Vietnam, and on possibilities of transfer of Japanese technologies. The 'Overseas workshop (Vietnam)' was held on September 28, 1999 with the 'trends and problems in coal production technologies' as the main theme. Lectures were given in the session related to coal production technologies by Vietnamese coal technology experts, each from VINACOAL and IMSAT, and by two Japanese coal technology experts. A comprehensive discussion was also executed, and items of technical information were exchanged on the coal production technologies. The number of persons actually participated in the workshop counted 58, with the proceedings presented by them distributed. The Mao Khe and Duong Huy coal mines in Quang Ninh Province were visited as the technical tour, whereas the coal mine sites were inspected and opinions were exchanged with the site engineers. Gas analysis was performed in the Mao Khe mine from the viewpoint of a gas control technology, and site investigation was carried out on lock bolts in the Duong Huy mine from the viewpoint of a roof control technology. (NEDO)

  8. Determinants of Foreign Technological Activity in German Regions

    DEFF Research Database (Denmark)

    Dettmann, Eva; Lacasa, Iciar Dominguez; Günther, Jutta;

    This paper analyses the determinants of spatial distribution of foreign technological activity across 96 German regions (1996-2009). We identify foreign inventive activity by applying the ‘cross-border-ownership concept’ to transnational patent applications. The descriptive analysis shows...... that foreign technological activity more than doubled during the observation period with persistent spatial heterogeneity in Germany. Using a pooled count data model, we estimate the effect of various sources for externalities on the extent of foreign technological activity across regions. Our results show...... that foreign technological activity is attracted by technologically specialised sectors of regions. In contrast to existing findings this effect applies both to foreign as well as domestic sources of specialisation. We show that the relation between specialization and foreign technological activity is non...

  9. Electron self-exchange activation parameters of diethyl sulfide and tetrahydrothiophene

    Directory of Open Access Journals (Sweden)

    Martin Goez

    2013-07-01

    Full Text Available Electron transfer between the title compounds and their radical cations, which were generated by photoinduced electron transfer from the sulfides to excited 2,4,6-triphenylpyrylium cations, was investigated by time-resolved measurements of chemically induced dynamic nuclear polarization (CIDNP in acetonitrile. The strongly negative activation entropies provide evidence for an associative–dissociative electron exchange involving dimeric radical cations. Despite this mechanistic complication, the free energies of activation were found to be well reproduced by the Marcus theory of electron transfer, with the activation barrier still dominated by solvent reorganization.

  10. Advanced Technologies for Contents Sharing, Exchanging and Searching in E-Learning Systems

    Science.gov (United States)

    De Pietro, Orlando; Appratto, Francesco

    2004-01-01

    In this article we explain a semantic analysis model derived from neural networks and pattern classification experiences, based on keyword sets. This model can be used for searching, analyzing, and composing documents in e-learning systems and for permitting inter-platform collaboration and data exchange. In particular, we explain some searching…

  11. Irreversible Catalyst Activation Enables Hyperpolarization and Water Solubility for NMR Signal Amplification by Reversible Exchange

    Science.gov (United States)

    2016-09-12

    p-H2 and substrate exchange on metal complexes ; however, instead of hydrogenation, hyperpolarization of the substrate molecule is achieved by transfer...35,36 The proper activation of Ir-IMes requires not only H2, but also the presence of sufficient substrate to form a fully coordinated Ir−hydride complex ...Magnetic Resonance of Laser-Polarized Noble Gases in Molecules , Materials, and Organisms . J. Magn. Reson. 2002, 155, 157−216. (5) Schroder, L. Xenon for

  12. Amine-functionalized, silver-exchanged zeolite NaY: Preparation, characterization and antibacterial activity

    Science.gov (United States)

    Hanim, Siti Aishah Mohd; Malek, Nik Ahmad Nizam Nik; Ibrahim, Zaharah

    2016-01-01

    Amine-functionalized, silver-exchanged zeolite NaY (ZSA) were prepared with three different concentrations of 3-aminopropyltriethoxysilane (APTES) (0.01, 0.20 and 0.40 M) and four different concentrations of silver ions (25%, 50%, 100% and 200% from zeolite cation exchange capacity (CEC)). The samples were characterized by Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), energy-dispersive X-ray (EDX), surface area analysis, thermogravimetric analysis (TGA) and zeta potential (ZP) analysis. The FTIR results indicated that the zeolite was functionalized by APTES and that the intensity of the peaks corresponding to APTES increased as the concentration of APTES used was increased. The antibacterial activities of the silver-exchanged zeolite NaY (ZS) and ZSA were studied against Escherichia coli ATCC11229 and Staphylococcus aureus ATCC6538 using the disc diffusion technique (DDT) and minimum inhibitory concentration (MIC). The antibacterial activity of ZSA increased with the increase in APTES on ZS, and E. coli was more susceptible towards the sample compared to S. aureus. The FESEM micrographs of the bacteria after contact with the ZSA suggested different mechanisms of bacterial death for these two bacteria due to exposure to the studied sample. The functionalization of ZS with APTES improved the antibacterial activity of the silver-zeolite, depending on the concentration of silver ions and APTES used during modification.

  13. Teachers' Purposeful Design of Effective Technology Learning Activities

    Science.gov (United States)

    Morgan, John Andrew Kerlin

    2014-01-01

    The goal of this study was to explore how exemplary teachers design learning activities that incorporate the use of technology. Teachers at three schools in a school district in Southern California were solicited for a survey regarding their use of technology in the classroom. Based on the surveys, high and low technology implementers were…

  14. The effects of various incubation temperatures, particulate isolation, and possible role of calmodulin on the activity of the base exchange enzymes of rat brain.

    Science.gov (United States)

    Buchanan, A G; Kanfer, J N

    1980-10-01

    The involvement of calmodulin in the choline, ethanolamine, and serine exchange activities of rat brain microsomes was investigated. Calmodulin stimulated choline exchange activity to a greater extent than ethanolamine and serine exchange activities. The three base exchange activities were inhibited by antipsychotic drugs believed to prevent calmodulin interaction, but not by calmodulin-binding protein. The solutions employed for tissue homogenization and subsequent isolation of microsomes greatly influenced the base exchange activities. The process of resuspending isolated microsomes and recentrifugation, or "washing," produced major losses of detectable activity. The base exchange enzyme activities were maximal at 45 degrees, and Arrhenius plots revealed a common transition temperature of 31 degrees. The activation energies for the base exchange reactions decreased at temperatures above the observed transition temperature. Kinetic data, Km and Vmax, for the base exchange activities at 27, 37, and 45 degrees are presented.

  15. Project to promote exchange of international information on environmental technologies; Kankyo gijutsu kokusai joho koryu sokushin jigyo

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    Mutual information exchange at international levels is important for practical application of global environment preservation technologies, whereas the APEC Virtual Center was established in fiscal 1997. Fiscal 1998 has discussed the future functions of the Virtual Center, and carried out the following matters to improve the functions and achieve its stable operation. Discussions were given on common use with the centers of other countries and regions of the specifications of classification systems for information areas and provided information that are provided by the Virtual Center. Visits were made to sub-managing countries and regions for smooth operation of the study groups, and opinions were exchanged. Visits were made to coordinators and contact points established in each country and region when the Center was founded in fiscal 1997. A visit was made to the U.S. Environmental Protection Agency to exchange opinions on coordination measures with the Cleaner Production Strategy of the U.S.A. being a project similar to the subject project. In order to strengthen the Japan's Center, attempts were made to expand the linking information to wider scope. Special pages publishing concentratedly the items of information that the users are interested were prepared as part of the information provision. (NEDO)

  16. Future Technology Workshop: A Collaborative Method for the Design of New Learning Technologies and Activities

    Science.gov (United States)

    Vavoula, Giasemi N.; Sharples, Mike

    2007-01-01

    We describe the future technology workshop (FTW), a method whereby people with everyday knowledge or experience in a specific area of technology use (such as using digital cameras) envision and design the interactions between current and future technology and activity. Through a series of structured workshop sessions, participants collaborate to…

  17. Nitroguanidine Wastewater Pollution Control Technology: Phase III. Ion Exchange and Carbon Adsorption Treatment

    Science.gov (United States)

    1984-03-01

    SD are synthetic cross-linked resins provided as moist spherical beads nominally of 50 percent water content. The clinoptilolite was supplied presized...Na+ i3 provided by a resin (either naturally occurring or synthetic ). Usually, the resin is prepared in a fixed-bed column, and hard water ion is...these :.ons as well as NQ. I/’ I . , I * MATERIALS AND METHODS RESINS AND CARBONS Three ion-exchange materials were studied: clinoptilolite , an

  18. NASA's Spaceliner Investment Area Technology Activities

    Science.gov (United States)

    Hueter, Uwe; Lyles, Garry M. (Technical Monitor)

    2001-01-01

    NASA's has established long term goals for access-to-space. The third generation launch systems are to be fully reusable and operational around 2025. The goals for the third generation launch system are to significantly reduce cost and improve safety over current conditions. The Advanced Space Transportation Program Office (ASTP) at the NASA's Marshall Space Flight Center in Huntsville, AL has the agency lead to develop space transportation technologies. Within ASTP, under the Spaceliner Investment Area, third generation technologies are being pursued in the areas of propulsion, airframes, integrated vehicle health management (IVHM), avionics, power, operations, and range. The ASTP program will mature these technologies through both ground and flight system testing. The Spaceliner Investment Area plans to mature vehicle technologies to reduce the implementation risks for future commercially developed reusable launch vehicles (RLV). The plan is to substantially increase the design and operating margins of the third generation RLV (the Space Shuttle is the first generation) by incorporating advanced technologies in propulsion, materials, structures, thermal protection systems, avionics, and power. Advancements in design tools and better characterization of the operational environment will allow improvements in design margins. Improvements in operational efficiencies will be provided through use of advanced integrated health management, operations, and range technologies. The increase in margins will allow components to operate well below their design points resulting in improved component operating life, reliability, and safety which in turn reduces both maintenance and refurbishment costs. These technologies have the potential of enabling horizontal takeoff by reducing the takeoff weight and achieving the goal of airline-like operation. These factors in conjunction with increased flight rates from an expanding market will result in significant improvements in safety

  19. Evaluating Efficiency of Tehran Stock Exchange: Case Study for Top Fifty Most Active Companies (TSE-50

    Directory of Open Access Journals (Sweden)

    Reza TALEBLOO

    2014-12-01

    Full Text Available Economics of information has been developing increasingly in economics literature in recent decades. Accordingly, the information plays a crucial role in efficiency of any market particularly capital market which deals more with this issue. As for the importance of information in stock exchange efficiency, the market efficiency is studied under three data sets in three forms including: 1- Information concerning the past prices, 2- All the released information and, 3- General Information and Confidential private information. Given these three types of information, market efficiency is checked in three weak, semi-strong and strong levels, respectively. This paper in order to examine the efficiency in the weak level employs a decomposed pattern with two stochastic and random terms for Top Fifty most active companies (TSE-50 in Tehran stock exchange based on both long and short horizons. The findings demonstrate that the indicator does not have efficiency in long horizon. This is while; the efficiency is verified in short horizon.

  20. E-Collaboration Technologies in Teaching/Learning Activity

    Science.gov (United States)

    Zascerinska, Jelena; Ahrens, Andreas

    2009-01-01

    A proper use of e-collaboration technologies in the teaching/learning process is provided by varied cooperative networks, which penetrate teachers' and students' activity more thoroughly with the availability of broadband services. However, the successful use of e-collaboration technologies in teaching/learning activity within a multicultural…

  1. Cu and Co exchanged ZSM-5 zeolites: activity towards no reduction and hydrocarbon oxidation

    Directory of Open Access Journals (Sweden)

    Martins Leandro

    2006-01-01

    Full Text Available |Cu x|[Si yAl]-MFI and |Co x|[Si yAl]-MFI catalysts were prepared by ion exchange from |Na|[Si yAl]-MFI zeolites (y = 12, 25 and 45. The activity of the catalysts was evaluated in the reduction of NO to N2 in an oxidative atmosphere using propane or methane as reducing agents. The Cu catalysts were only active with propane and they presented higher activity than the Co-based catalysts, the latter being active with both hydrocarbons. H2-TPR and DRS-UV/Vis data allowed correlation between the activity towards NO reduction and the presence of cationic charge-compensating species in the zeolite. It was also verified that the hydrocarbons are preferentially oxidised by O2, a reaction that occurs simultaneously with their oxidation with NO.

  2. Immunoglobulin domain interface exchange as a platform technology for the generation of Fc heterodimers and bispecific antibodies

    Science.gov (United States)

    Skegro, Darko; Stutz, Cian; Ollier, Romain; Svensson, Emelie; Wassmann, Paul; Bourquin, Florence; Monney, Thierry; Gn, Sunitha; Blein, Stanislas

    2017-01-01

    Bispecific antibodies (bsAbs) are of significant importance to the development of novel antibody-based therapies, and heavy chain (Hc) heterodimers represent a major class of bispecific drug candidates. Current technologies for the generation of Hc heterodimers are suboptimal and often suffer from contamination by homodimers posing purification challenges. Here, we introduce a new technology based on biomimicry wherein the protein-protein interfaces of two different immunoglobulin (Ig) constant domain pairs are exchanged in part or fully to design new heterodimeric domains. The method can be applied across Igs to design Fc heterodimers and bsAbs. We investigated interfaces from human IgA CH3, IgD CH3, IgG1 CH3, IgM CH4, T-cell receptor (TCR) α/β, and TCR γ/δ constant domain pairs, and we found that they successfully drive human IgG1 CH3 or IgM CH4 heterodimerization to levels similar to or above those of reference methods. A comprehensive interface exchange between the TCR α/β constant domain pair and the IgG1 CH3 homodimer was evidenced by X-ray crystallography and used to engineer examples of bsAbs for cancer therapy. Parental antibody pairs were rapidly reformatted into scalable bsAbs that were free of homodimer traces by combining interface exchange, asymmetric Protein A binding, and the scFv × Fab format. In summary, we successfully built several new CH3- or CH4-based heterodimers that may prove useful for designing new bsAb-based therapeutics, and we anticipate that our approach could be broadly implemented across the Ig constant domain family. To our knowledge, CH4-based heterodimers have not been previously reported. PMID:28450393

  3. Involvement of mitochondrial Na+-Ca2+ exchange in intestinal pacemaking activity

    Institute of Scientific and Technical Information of China (English)

    Byung Joo Kim; Jae Yeoul Jun; Insuk So; Ki Whan Kim

    2006-01-01

    AIM: Interstitial cells of Cajal (ICCs) are the pacemaker cells that generate slow waves in the gastrointestinal (GI) tract. We have aimed to investigate the involvement of mitochondrial Na+-Ca2+ exchange in intestinal pacemaking activity in cultured interstitial cells of Cajal.METHODS: Enzymatic digestions were used todissociate ICCs from the small intestine of a mouse. The whole-cell patch-clamp configuration was used to record membrane currents (voltage clamp) and potentials (current clamp) from cultured ICCs.RESULTS: Clonazepam and CGP37157 inhibited the pacemaking activity of ICCs in a dose-dependent manner.Clonazepam from 20 to 60 μmol/L and CGP37157 from 10 to 30 μmol/L effectively inhibited Ca2+ efflux from mitochondria in pacemaking activity of ICCs. The IC50S of clonazepam and CGP37157 were 37.1 and 18.2 μmol/L, respectively. The addition of 20 μmol/L NiCl2 to the internal solution caused a "wax and wane" phenomenon of pacemaking activity of ICCs.CONCLUSION: These results suggest that mitochondrial Na+-Ca2+ exchange has an important role in intestinal pacemaking activity.

  4. Fiscal 1999 engineer exchange project (field of coal mining technology), international exchange project. Domestic workshop; 1999 nendo gijutsusha koryu jigyo (tanko gijutsu bun'ya) kokusai koryu jigyo. Kokunai workshop

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    The domestic workshop invites Japanese engineers and engineers from coal producing countries for the exchange of coal mining technologies and aims to substantiate and facilitate the dispatching and receiving of engineers under training programs. The main subject of the Asia-Pacific coal technology workshop was 'Coal for the 21st century - resources and technology,' and there were two sessions held on September 8, titled 'Trends and tasks of coal resources exploitation' and 'Coal resources and production technology.' Lectures were delivered by five overseas and five Japanese coal engineering experts. On September 9, nine essays were presented concerning 'Coal resources and security problems' and 'Coal resources and environmental problems.' In addition, a panel discussion was held, titled 'Coal resources assessment and technology.' Importance was emphasized of the correct assessment of the magnitude of resources, development of probing technologies to collect more detailed information, improvement of digging speeds applicable to faces for large and high-efficiency mining, development of coal mining technologies for increased recovery, etc. Information was exchanged on various occasions and partnership was enhanced between the participants to the advantage of engineer exchanging projects in the future. (NEDO)

  5. NASA's Spaceliner 100 Investment Area Technology Activities

    Science.gov (United States)

    Hueter, Uwe; Lyles, Garry M. (Technical Monitor)

    2001-01-01

    NASA's has established long term goals for access-to-space. The third generation launch systems are to be fully reusable and operational around 2025. The goals for the third generation launch system are to reduce cost by a factor of 100 and improve safety by a factor of 10,000 over current conditions. The Advanced Space Transportation Program Office (ASTP) at the NASA's Marshall Space Flight Center in Huntsville, AL has the agency lead to develop space transportation technologies. Within ASTP, under the Spaceliner100 Investment Area, third generation technologies are being pursued in the areas of propulsion, airframes, integrated vehicle health management (IVHM), launch systems, and operations and range. The ASTP program will mature these technologies through ground system testing. Flight testing where required, will be advocated on a case by case basis.

  6. LDR structural technology activities at JPL

    Science.gov (United States)

    Wada, Ben

    1988-01-01

    The status of the Large Deployable Reflector (LDR) technology requirements and the availability of that technology in the next few years are summarized. The research efforts at JPL related to these technology needs are also discussed. LDR requires that a large and relatively stiff truss-type backup structure have a surface accurate to 100 microns in space (initial position with thermal distortions) and the dynamic characteristics predictable and/or measurable by on-orbit system identification for micron level motion. This motion may result from the excitation of the lower modes or from wave-type motions. It is also assumed that the LDR structure can be ground tested to validate its ability to meet mission requirements. No program manager will commit a structural design based solely on analysis, unless the analysis is backed by a validation test program.

  7. Ion Exchange Technology Development in Support of the Urine Processor Assembly

    Science.gov (United States)

    Mitchell, Julie; Broyan, James; Pickering, Karen

    2013-01-01

    The urine processor assembly (UPA) on the International Space Station (ISS) recovers water from urine via a vacuum distillation process. The distillation occurs in a rotating distillation assembly (DA) where the urine is heated and subjected to sub-ambient pressure. As water is removed, the original organics, salts, and minerals in the urine become more concentrated and result in urine brine. Eventually, water removal will concentrate the urine brine to super saturation of individual constituents, and precipitation occurs. Under typical UPA DA operating conditions, calcium sulfate or gypsum is the first chemical to precipitate in substantial quantity. During preflight testing with ground urine, the UPA achieved 85% water recovery without precipitation. However, on ISS, it is possible that crewmember urine can be significantly more concentrated relative to urine from ground donors. As a result, gypsum precipitated in the DA when operating at water recovery rates at or near 85%, causing the failure and subsequent re14 NASA Tech Briefs, September 2013 placement of the DA. Later investigations have demonstrated that an excess of calcium and sulfate will cause precipitation at water recovery rates greater than 70%. The source of the excess calcium is likely physiological in nature, via crewmembers' bone loss, while the excess sulfate is primarily due to the sulfuric acid component of the urine pretreatment. To prevent gypsum precipitation in the UPA, the Precipitation Prevention Project (PPP) team has focused on removing the calcium ion from pretreated urine, using ion exchange resins as calcium removal agents. The selectivity and effectiveness of ion exchange resins are determined by such factors as the mobility of the liquid phase through the polymer matrix, the density of functional groups, type of functional groups bound to the matrix, and the chemical characteristics of the liquid phase (pH, oxidation potential, and ionic strength). Previous experience with ion

  8. New monolith technology for automated anion-exchange purification of nucleic acids.

    Science.gov (United States)

    Thayer, J R; Flook, K J; Woodruff, A; Rao, S; Pohl, C A

    2010-04-15

    Synthetic nucleic acid analysis often employs pellicular anion-exchange (AE) chromatography because it supports very high efficiency separations while offering means to control secondary structure, retention and resolution by readily modifiable chromatographic conditions. However, these pellicular anion-exchange (pAE) phases do not offer capacity sufficient for lab-scale oligonucleotide (ON) purification. In contrast, monolithic phases produce fast separations at capacities exceeding their pellicular counterparts, but do not exhibit capacities typical of fully porous, bead-based, anion-exchangers. In order to further increase monolith capacity and obtain the selectivity and mass transfer characteristics of pellicular phases, a surface-functionalized monolith was coated with pAE nanobeads (latexes) usually employed on the pellicular DNAPac phase. The nanobead-coated monolith exhibited chromatographic behaviors typical of polymer AE phases. Based on this observation the monolithic substrate surface porosity and latex diameters were co-optimized to produce a hybrid monolith harboring capacity similar to that of fully porous bead-based phases and peak shape approaching that of the pAE phases. We tested the hybrid monolith on a variety of previously developed pAE capabilities including control of ON selectivity, resolution of derivatized ONs, the ability to resolve RNA ONs harboring aberrant linkages at different positions in a single sequence and separation of phosphorothioate diastereoisomers. We compared the yield and purity of an 8 mg ON sample purified on both the new hybrid monolith and a benchmark AE column based on fully porous monodisperse beads. This comparison included an assessment of the relative selectivities of both columns. Finally, we demonstrated the ability to couple AE ON separations with ESI-MS using an automated desalting protocol. This protocol is also useful for preparing ONs for other assays, such as enzyme treatments, that may be sensitive to

  9. Technological aspects of vegetable oils epoxidation in the presence of ion exchange resins: a review

    National Research Council Canada - National Science Library

    Eugeniusz Milchert; Kornelia Malarczyk-Matusiak; Marlena Musik

    2016-01-01

    ..., the relative percentage conversion to oxirane and the iodine number was discussed. Optimal technological parameters, mechanism of epoxidation by carboxylic peracids and the possibilities of catalyst recycling have been also discussed...

  10. Technology of remote monitoring for nuclear activity monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Kwack, Ehn Ho; Kim, Jong Soo; Yoon, Wan Ki; Park, Sung Sik; Na, Won Woo; An, Jin Soo; Cha, Hong Ryul; Kim, Jung Soo

    2000-05-01

    In a view of safeguards monitoring at nuclear facilities, the monitoring is changing to remote method so that this report is described to remote monitoring(RM) applying on commercial NPP in Korea. To enhance IAEA safeguards efficiency and effectiveness, IAEA is taking into account of remote monitoring system(RMS) and testing as a field trial. IRMP(International Remote Monitoring Project) in participating many nations for development of RMS is proceeding their project such as technical exchange and research etc. In case of our country are carrying out the research relevant RM since acceptance RMS at 7th ROK-IAEA safeguards implementation review meeting. With a view to enhancement the RMS, installation location and element technology of the RM equipment are evaluated in a view of safeguards in Korea LWRs, and proposed a procedure for national inspection application through remote data evaluation from Younggwang-3 NPP. These results are large valuable to use of national inspection at time point extending installation to all Korea PWR NPP. In case of CANDU, neutron, gamma measurement and basic concept of network using optical fiber scintillating detector as remote verification method for dry storage canister are described. Also RM basic design of spent fuel transfer campaign is described that unattended RM without inspector instead of performing in participating together with IAEA and national inspector. The transfer campaign means the spent fuel storage pond to dry storage canister for about two months every year. Therefore, positively participation of IAEA strength safeguards project will be increased transparency for our nuclear activity as well as contributed to national relevant industry.

  11. Ion-exchangeable titanate nanotubes with visible light responsive photocatalytic activities for dyes degradation.

    Science.gov (United States)

    Li, Xiukai; Zhong, Yushu

    2014-09-01

    Sn(2+)- and Pb(2+)-substituted NaHTi3O7 nanotubes were prepared by a hydrothermal synthesis method followed by ion-exchange reaction. The samples were characterized by XRD, SEM, TEM, XPS and UV-visible diffuse reflectance spectroscopy. The photocatalytic activities were investigated for the photodegradation of methylene orange (MO) and methylene blue (MB) under visible light irradiation. The results indicate that Sn2+ and Pb2+ substitutions could have significant impacts on the optical properties and photocatalytic activities of samples. Both Sn(2+)- and Pb(2+)-substituted NaHTi3O7 nanotubes show activities for methylene orange and methylene blue photodegradation under visible light irradiation. With better absorption of visible light, the Sn-NaHTi3O7 sample showed higher activity than Pb-NaHTi3O7.

  12. Extravehicular Activity Technology Development Status and Forecast

    Science.gov (United States)

    Chullen, Cinda; Westheimer, David T.

    2011-01-01

    The goal of NASA s current EVA technology effort is to further develop technologies that will be used to demonstrate a robust EVA system that has application for a variety of future missions including microgravity and surface EVA. Overall the objectives will be to reduce system mass, reduce consumables and maintenance, increase EVA hardware robustness and life, increase crew member efficiency and autonomy, and enable rapid vehicle egress and ingress. Over the past several years, NASA realized a tremendous increase in EVA system development as part of the Exploration Technology Development Program and the Constellation Program. The evident demand for efficient and reliable EVA technologies, particularly regenerable technologies was apparent under these former programs and will continue to be needed as future mission opportunities arise. The technological need for EVA in space has been realized over the last several decades by the Gemini, Apollo, Skylab, Space Shuttle, and the International Space Station (ISS) programs. EVAs were critical to the success of these programs. Now with the ISS extension to 2028 in conjunction with a current forecasted need of at least eight EVAs per year, the EVA hardware life and limited availability of the Extravehicular Mobility Units (EMUs) will eventually become a critical issue. The current EMU has successfully served EVA demands by performing critical operations to assemble the ISS and provide repairs of satellites such as the Hubble Space Telescope. However, as the life of ISS and the vision for future mission opportunities are realized, a new EVA systems capability will be needed and the current architectures and technologies under development offer significant improvements over the current flight systems. In addition to ISS, potential mission applications include EVAs for missions to Near Earth Objects (NEO), Phobos, or future surface missions. Surface missions could include either exploration of the Moon or Mars. Providing an

  13. The TECS model leads to active use of technology in home care

    DEFF Research Database (Denmark)

    Jensen, Ulla Gars; Skov, Hanne

    2016-01-01

    Digitization in healthcare is accelerating worldwide. This article focuses on the X-Changery development project involving home-care nurses and their use of the iPad as a new tool in patients’ homes. The goal of the project was to bring knowledge from recent research on technological literacy...... in working life back to a work setting, thus giving nurses new technology competencies with the aim of enhancing their professionalism through the use of the iPad as a work tool. Through field observations, learning labs and focus-group interviews we can see that X-Changery gave home-care nurses a common...... language to exchange experiences and share knowledge about the iPad as a work tool. Use of the iPad in patients’ homes led to new habits and routines. Nurses acquired relational expertise, implying active use of technology. The results show the importance of focusing on and funding reflection...

  14. Engineer exchanging project (coal mine technology field) in fiscal 1999. International information exchanging project (advance survey on Russia); 1999 nendo gijutsusha koryu jigyo (tanko gijutsu bun'ya) kokusai koryu jigyo. Jizen chosa (Roshia)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    This advance survey on Russia has performed visiting surveys and information collection at coal related organizations inside Japan and in overseas countries on production technology levels, trends and technology exchange needs in overseas coal producing countries. The project is intended to serve for improvement in the contents of and smooth execution of the engineer exchange project in the 'coal mine technology field. It was carried out by expertise people as the site surveys and the engineer reception and exchange surveys. Because of the economic crisis that has hit Russia in 1998, unprofitable coal mines were closed one after another under the coal mine scrap and build policy under the initiative of the World Bank. This situation is giving serious impacts on coal mines in the Far East Russia and the coastal areas. However, the importance of coal as the primary energy source has not been changed at all in the Far East Russia. Thus, the areas have fallen into a situation that they must rely on a great amount of introduced and imported coals as a result of weakening in coal mines in the Far Eastern area on the other hand. This paper reports mainly the situation in which the coal industries in the coastal areas are placed, and the possibilities of technology exchange. (NEDO)

  15. U.S.-MEXICO TECHNOLOGY TRANSFER; BILATERAL TECHNICAL EXCHANGES FOR SUSTAINABLE ECONOMIC GROWTH IN THE BORDER REGION

    Energy Technology Data Exchange (ETDEWEB)

    Jimenez, Richard, D., Dr.

    2007-10-01

    The U.S. Department of Energy (DOE) maintains a strong commitment to transfer the results of its science and technology programs to the private sector. The intent is to apply innovative and sometimes advanced technologies to address needs while simultaneously stimulating new commercial business opportunities. Such focused “technology transfer” was evident in the late 1990s as the results of DOE investments in environmental management technology development led to new tools for characterizing and remediating contaminated sites as well as handling and minimizing the generation of hazardous wastes. The Department’s Office of Environmental Management was attempting to reduce the cost, accelerate the schedule, and improve the efficacy of clean-up efforts in the nuclear weapons complex. It recognized that resulting technologies had broader world market applications and that their commercialization would further reduce costs and facilitate deployment of improved technology at DOE sites. DOE’s Albuquerque Operations Office (now part of the National Nuclear Security Administration) began in 1995 to build the foundation for a technology exchange program with Mexico. Initial sponsorship for this work was provided by the Department’s Office of Environmental Management. As part of this effort, Applied Sciences Laboratory, Inc. (ASL) was contracted by the DOE Albuquerque office to identify Mexico’s priority environmental management needs, identify and evaluate DOE-sponsored technologies as potential solutions for those needs, and coordinate these opportunities with decision makers from Mexico’s federal government. That work led to an improved understanding of many key environmental challenges that Mexico faces and the many opportunities to apply DOE’s technologies to help resolve them. The above results constituted, in large part, the foundation for an initial DOE-funded program to apply the Department’s technology base to help address some of Mexico

  16. The Analysis of Activated Carbon Regeneration Technologies

    Institute of Scientific and Technical Information of China (English)

    姚芳

    2014-01-01

    A series of methods for activated carbon regeneration were briefly introduced.Such as thermal regeneration,chemical regeneration,biochemical regeneration,and newly supercritical fluid regeneration, electrochemical regeneration,light-catalyzed regeneration,and microwave radiation method,and the developing trend of activated carbon regeneration was predicted.

  17. Culturelogical senses of activity in anthropic technologies of higher education

    Directory of Open Access Journals (Sweden)

    Dmitriev S.V.

    2010-04-01

    Full Text Available Technology of the educational teaching motive actions is examined in a theory and practice of higher education. The role of modern educational technologies is rotined in professional preparation of students. «Humanism conversion» of educational technologies is offered. It is rotined that authentic sense of educational activity of man is finding by him itself (achievement of authenticness with itself. On the basis of it is creative realization in professional labour.

  18. Promoting Technology-Assisted Active Learning in Computer Science Education

    Science.gov (United States)

    Gao, Jinzhu; Hargis, Jace

    2010-01-01

    This paper describes specific active learning strategies for teaching computer science, integrating both instructional technologies and non-technology-based strategies shown to be effective in the literature. The theoretical learning components addressed include an intentional method to help students build metacognitive abilities, as well as…

  19. FY 2000 international exchange project on exchanges of engineers - Coal mine technology field. Overseas workshop (China); 2000 nendo gijutsusha koryu jigyo (tanko gijutsu bun'ya) kokusai koryu jigyo. Kaigai workshop (Chugoku)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    For the purpose of making technical exchanges with coal mine related engineers in China and surveying levels of coal production technology and the needs in China and possibilities of technology transfer from Japan, workshop was held and technical tours were made. On December 13, 2000, a workshop was held in China which was named 'Japan-China Joint Coal Project Workshop: Environment/Production/Security.' Participants were 112 including 16 from Japan and 96 from China. Subjects were as follows: subjects on coal resource and technical strategy in the 21st century, technical exchange project and technical development, Japan-China technical cooperation project, report on the operational situation of China Coal Industry Environmental Preservation Safety Training Center, Japan-China Joint Project on spontaneous combustion prevention technology, CMG recovery/utilization system joint demonstration project, Japan-China joint coal exploration project, Japan-China coal field geology joint exploration project, etc. (NEDO)

  20. U.S.-MEXICO TECHNOLOGY TRANSFER; BILATERAL TECHNICAL EXCHANGES FOR SUSTAINABLE ECONOMIC GROWTH IN THE BORDER REGION

    Energy Technology Data Exchange (ETDEWEB)

    Jimenez, Richard, D., Dr.

    2007-10-01

    The U.S. Department of Energy (DOE) maintains a strong commitment to transfer the results of its science and technology programs to the private sector. The intent is to apply innovative and sometimes advanced technologies to address needs while simultaneously stimulating new commercial business opportunities. Such focused “technology transfer” was evident in the late 1990s as the results of DOE investments in environmental management technology development led to new tools for characterizing and remediating contaminated sites as well as handling and minimizing the generation of hazardous wastes. The Department’s Office of Environmental Management was attempting to reduce the cost, accelerate the schedule, and improve the efficacy of clean-up efforts in the nuclear weapons complex. It recognized that resulting technologies had broader world market applications and that their commercialization would further reduce costs and facilitate deployment of improved technology at DOE sites. DOE’s Albuquerque Operations Office (now part of the National Nuclear Security Administration) began in 1995 to build the foundation for a technology exchange program with Mexico. Initial sponsorship for this work was provided by the Department’s Office of Environmental Management. As part of this effort, Applied Sciences Laboratory, Inc. (ASL) was contracted by the DOE Albuquerque office to identify Mexico’s priority environmental management needs, identify and evaluate DOE-sponsored technologies as potential solutions for those needs, and coordinate these opportunities with decision makers from Mexico’s federal government. That work led to an improved understanding of many key environmental challenges that Mexico faces and the many opportunities to apply DOE’s technologies to help resolve them. The above results constituted, in large part, the foundation for an initial DOE-funded program to apply the Department’s technology base to help address some of Mexico

  1. In-situ NMR studies of isobutane activation and exchange in zeolite beta.

    Science.gov (United States)

    Truitt, Matthew J; White, Jeffery L

    2009-04-01

    (1)H solid-state NMR techniques have been used to simultaneously detect the reactivity of both catalyst and alkane reactant protons in an in-situ experimental design. Specifically, the activation of isobutane C-H bonds by the solid acid zeolite H-Beta is directly observed while the reaction is in progress, and the rate of proton transfer between the solid catalyst surface and gaseous isobutane is quantitatively measured using isotopic (1)H/(2)H exchange methods. Arrhenius analysis of isothermal kinetic runs revealed an apparent activation barrier of 70kJ/mole for the exchange process between isobutane and the 12-membered ring H-Beta, which exceeds our previously determined value of 57kJ/mole for isobutane in the 10-membered ring H-ZSM-5 (JACS 2006, v. 128, p. 1848). Estimation of true activation energies using heat of adsorption data from the literature combined with the experimentally measured apparent E(a) suggests that the true activation barrier differs by only 6-7kJ/mole in the two catalysts. We discuss the possibility that subtle shape selectivity, or inverse shape selectivity, and lattice solvation differences between the two catalysts account for the enhanced solvation of the isobutane transition state in HZSM-5 compared to the larger channel H-Beta. In all experiments, the isobutane reagent was treated to eliminate any unsaturated impurities that might serve as initiators for carbenium-ion mechanisms, and the active catalyst was free of any organic contaminants that might serve as a source of unsaturated initiators.

  2. A development of the stabilization technology for the solid form of ion exchange resin

    Energy Technology Data Exchange (ETDEWEB)

    Kim, T. K.; Lee, Y. H.; Kang, I. S.; Bae, S. M; Ahn, S. J.; Lee, K. M.; Kim, K. J.; Son, J. S.; Hong, K. P. [KAERI, Taejon (Korea, Republic of)

    2003-10-01

    In this study, a modified bituminization technology has been developed, which needs no grinding of the granular resin waste, and enables the solid form to keep its shape stability as good as that of a cemented solid form. Also, the study intended to apply the developed technology to the practical treatment of radioactive resin waste. In the experiment, the granular type resin was used and the straight-run distillation bitumen with penetration rate 60/70 was used as the solidifying agent. The PE was used as the additive. The shape stability increased remarkably with the additive of PE, which act as a binder in the solid form. The shape of the solid form was maintained without failure during the long-term exposure test when the additive content of spent PE is more than 10wt %. The proper ranges of bitumen content, PE content and operating temperature are 30-50wt%, 10-20wt% and 180 .deg. C respectively. The bituminized solid form of radioactive resin waste by the technology of this study has the remarkably superior quality than the conventional solid forms, partially for the shape stability.

  3. Determinants of Foreign Technological Activity in German Regions

    DEFF Research Database (Denmark)

    Dettmann, Eva; Lacasa, Iciar Dominguez; Günther, Jutta

    This paper analyses the determinants of spatial distribution of foreign technological activity across 96 German regions (1996-2009). We identify foreign inventive activity by applying the ‘cross-border-ownership concept’ to transnational patent applications. The descriptive analysis shows......-linear and that it is influenced by sectoral heterogeneity. Externalities related to technological diversification attract foreign R&D only into ‘higher order’ regions....

  4. Using contemporary liquid chromatography theory and technology to improve capillary gradient ion-exchange separations.

    Science.gov (United States)

    Wouters, Bert; Broeckhoven, Ken; Wouters, Sam; Bruggink, Cees; Agroskin, Yury; Pohl, Christopher A; Eeltink, Sebastiaan

    2014-11-28

    The gradient-performance limits of capillary ion chromatography have been assessed at maximum system pressure (34.5 MPa) using capillary columns packed with 4.1 μm macroporous anion-exchange particles coated with 65 nm positively-charged nanobeads. In analogy to the van-Deemter curve, the gradient performance was assessed applying different flow rates, while decreasing the gradient time inversely proportional to the increase in flow rate in order to maintain the same retention properties. The gradient kinetic-performance limits were determined at maximum system pressure, applying tG/t0=5, 10, and 20. In addition, the effect of retention on peak width was assessed in gradient mode for mono-, di-, and trivalent inorganic anions. The peak width of late-eluting ions can be significantly reduced by using concave gradient, resulting in better detection sensitivity. A signal enhancement factor of 8 was measured for a late-eluting ion when applying a concave instead of a linear gradient. For the analysis of a complex anion mixture, a coupled column with a total length of 1.05 m was operated at the kinetic-performance limit applying a linear 250 min gradient (tG/t0=10). The peak capacity varied between 200 and 380 depending on analyte retention, and hence on charge and size of the ion.

  5. Proceedings of the workshop for exchange of technology for CWC inspections

    Energy Technology Data Exchange (ETDEWEB)

    McGuire, R.R.

    1993-04-01

    With the signing of the Chemical Weapons Convention (CWC), the work of the Preparatory Commission in defining the modalities of on-site verification inspections will begin early in 1993. One of the methods for increasing the effectiveness of inspections is the collection of samples for chemical analysis. The CWC allows for this analysis to be performed either at the site of the inspection or in a dedicated off-site laboratory. The decision as to where samples are to be analyzed in any specific instance may involve a consideration of the threat, real or perceived, to the compromise of legitimate sensitive host-party information. The ability to perform efficient chemical analysis at the inspection site, where samples remain in joint (host-inspector) custody and the analytical procedures can be observed by the host, can alleviate much of the concern over possible loss of confidential information in both government and industry. This workshop was designed to encourage the exchange of information among participants with experience in the use of analytical equipment for on-site sample collection and analysis. Individual projects are processed separately for the databases.

  6. Unusual Market Activity Announcements: A Study of Price Manipulation on the Indonesian Stock Exchange

    Directory of Open Access Journals (Sweden)

    Mamduh M. Hanafi

    2010-05-01

    Full Text Available We investigate stocks involved in the Unusual Market Activity (UMA Announcements. The Indonesian Stock Exchange occasionally issues UMA announcements when it suspects that there are unusual price increases (positive UMAs or price decreases (negative UMAs, as well as unusual increases in trading volumes. We believe that UMA announcements signal a high probability that stocks are being manipulated. We find no differences in fundamentals and trading variables between stocks in the UMA announcements and those not in the UMA announcements. Any stock is vulnerable to market manipulation. Stocks in the UMA announcements do not exhibit reversal patterns, suggesting that price effect is permanent. UMAs seem to convey relevant information, which is most likely in the form of insider type of information. Keywords: emerging market; price manipulation; unusual market activity announcement.

  7. Technology to promote and increase physical activity in heart failure.

    Science.gov (United States)

    Franklin, Nina C

    2015-01-01

    Regular physical activity is firmly recommended as part of a multifaceted approach to heart failure (HF) self-management. Unfortunately, research indicates that most patients are less likely to engage in and adhere to such activities. The widespread use of information and communication technology tools and resources offers an innovative and potentially beneficial avenue for increasing physical activity levels in HF patients. This article presents specific ways in which advances in information and communication technologies, including Internet- and mobile-based communications, social media platforms, and self-monitoring health devices, can serve as a means to broadly promote increasing levels of physical activity to improve health outcomes in the HF population.

  8. PARP1 orchestrates variant histone exchange in signal-mediated transcriptional activation.

    Science.gov (United States)

    O'Donnell, Amanda; Yang, Shen-Hsi; Sharrocks, Andrew D

    2013-12-01

    Transcriptional activation is accompanied by multiple molecular events that remodel the local chromatin environment in promoter regions. These molecular events are often orchestrated in response to the activation of signalling pathways, as exemplified by the response of immediate early genes such as FOS to ERK MAP kinase signalling. Here, we demonstrate that inducible NFI recruitment permits PARP1 binding to the FOS promoter by a mutually reinforcing loop. PARP1 and its poly(ADP-ribosyl)ation activity are required for maintaining FOS activation kinetics. We also show that the histone variant H2A.Z associates with the FOS promoter and acts in a transcription-suppressive manner. However, in response to ERK pathway signalling, H2A.Z is replaced by H2A; PARP1 activity is required to promote this exchange. Thus, our work has revealed an additional facet of PARP1 function in promoting dynamic remodelling of promoter-associated nucleosomes to allow transcriptional activation in response to cellular signalling.

  9. Exchange factors directly activated by cAMP mediate melanocortin 4 receptor-induced gene expression

    Science.gov (United States)

    Glas, Evi; Mückter, Harald; Gudermann, Thomas; Breit, Andreas

    2016-01-01

    Gs protein-coupled receptors regulate many vital body functions by activation of cAMP response elements (CRE) via cAMP-dependent kinase A (PKA)-mediated phosphorylation of the CRE binding protein (CREB). Melanocortin 4 receptors (MC4R) are prototypical Gs-coupled receptors that orchestrate the hypothalamic control of food-intake and metabolism. Remarkably, the significance of PKA for MC4R-induced CRE-dependent transcription in hypothalamic cells has not been rigorously interrogated yet. In two hypothalamic cell lines, we observed that blocking PKA activity had only weak or no effects on reporter gene expression. In contrast, inhibitors of exchange factors directly activated by cAMP-1/2 (EPAC-1/2) mitigated MC4R-induced CRE reporter activation and mRNA induction of the CREB-dependent genes c-fos and thyrotropin-releasing hormone. Furthermore, we provide first evidence that extracellular-regulated kinases-1/2 (ERK-1/2) activated by EPACs and not PKA are the elusive CREB kinases responsible for MC4R-induced CREB/CRE activation in hypothalamic cells. Overall, these data emphasize the pivotal role of EPACs rather than PKA in hypothalamic gene expression elicited by a prototypical Gs-coupled receptor. PMID:27612207

  10. Fiscal 1999 international engineer exchange project (Coal mining technology field). Overseas workshop (Australia); 1999 nendo gijutsusha koryu jigyo (tanko gijutsu bun'ya) kokusai koryu jigyo. Kaigai workshop (Goshu)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    This report summarizes the technology exchange with Australian coal mining engineers, the technical levels and needs on coal production, safety and environment in Australia, and the FS result on transfer of Japanese technologies, engineer exchange and joint research in a coal mining technology field. The overseas workshop (Australia) was held on Nov. 9, 1999 (Tues.) in Brisbane, Queensland. The Australia-Japan Technology Exchange Workshop on coal resources and coal mining technology includes 5 sessions (keynote address, trends and issues of coal resource development, coal resources and production technology, coal resources and safety technology, coal resources and environmental problems), and the open forum discussion on innovative technologies for coal mining. 6 Japanese specialists and 11 Australian specialists read papers. After the workshop, the participants visited Liddell Mine in New South Wales to master natural conditions, and production and safety technology levels of Australian coal mines, and to exchange various information with Australian coal mining engineers. (NEDO)

  11. USE OF GAC TECHNOLOGY AND TWO STAGE ION EXCHANGE TECHNIQUE FOR RECYCLING OF WASTEWATER IN TEXTILE WET PROCESSING

    Directory of Open Access Journals (Sweden)

    PROF. MAHESH B. CHOUGULE

    2012-01-01

    Full Text Available Water is essential natural resource for sustaining life and environment, which is always thought to be available in abundance and free gift of nature. Textile industries are one of the major consumers of water and disposing large volumes of effluent to the environment. The textile industry utilizes abundant water in dyeing and finishing processes. There is need to adopt economical practices for the use of water in textile industries. It has been estimated that 3.5 % of the total cost of running the industry is required for water utilization in textile industry. In India textile units are developed all over the country in the form of small industrial estates. Textiles are manufactured to perform a multitude of functions. They are produced to a range of specifications using avariety of fibers, resulting in a complex waste or effluent. Textile waste occurs in a variety of forms throughout production process. The surface water sources are limited and availability of water from them vary from year to year depending upon monsoon conditions. The underground water resources are also getting depleted with theincreasing amount of water drawn from them every year without adequate replenishments. Therefore, the cost of water is rising steeply and the textile mills, which need a large quantity of water, have started taking measures to conserve and recycling. This paper focuses on recycling of wastewater in textile wet processing with experimental analysis of GAC technology and two-stage ion exchange technology.

  12. The Guanine Nucleotide Exchange Factor ARNO mediates the activation of ARF and phospholipase D by insulin

    Science.gov (United States)

    Li, Hai-Sheng; Shome, Kuntala; Rojas, Raúl; Rizzo, Mark A; Vasudevan, Chandrasekaran; Fluharty, Eric; Santy, Lorraine C; Casanova, James E; Romero, Guillermo

    2003-01-01

    Background Phospholipase D (PLD) is involved in many signaling pathways. In most systems, the activity of PLD is primarily regulated by the members of the ADP-Ribosylation Factor (ARF) family of GTPases, but the mechanism of activation of PLD and ARF by extracellular signals has not been fully established. Here we tested the hypothesis that ARF-guanine nucleotide exchange factors (ARF-GEFs) of the cytohesin/ARNO family mediate the activation of ARF and PLD by insulin. Results Wild type ARNO transiently transfected in HIRcB cells was translocated to the plasma membrane in an insulin-dependent manner and promoted the translocation of ARF to the membranes. ARNO mutants: ΔCC-ARNO and CC-ARNO were partially translocated to the membranes while ΔPH-ARNO and PH-ARNO could not be translocated to the membranes. Sec7 domain mutants of ARNO did not facilitate the ARF translocation. Overexpression of wild type ARNO significantly increased insulin-stimulated PLD activity, and mutations in the Sec7 and PH domains, or deletion of the PH or CC domains inhibited the effects of insulin. Conclusions Small ARF-GEFs of the cytohesin/ARNO family mediate the activation of ARF and PLD by the insulin receptor. PMID:12969509

  13. Irreversible catalyst activation enables hyperpolarization and water solubility for NMR signal amplification by reversible exchange.

    Science.gov (United States)

    Truong, Milton L; Shi, Fan; He, Ping; Yuan, Bingxin; Plunkett, Kyle N; Coffey, Aaron M; Shchepin, Roman V; Barskiy, Danila A; Kovtunov, Kirill V; Koptyug, Igor V; Waddell, Kevin W; Goodson, Boyd M; Chekmenev, Eduard Y

    2014-12-04

    Activation of a catalyst [IrCl(COD)(IMes)] (IMes = 1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene; COD = cyclooctadiene)] for signal amplification by reversible exchange (SABRE) was monitored by in situ hyperpolarized proton NMR at 9.4 T. During the catalyst-activation process, the COD moiety undergoes hydrogenation that leads to its complete removal from the Ir complex. A transient hydride intermediate of the catalyst is observed via its hyperpolarized signatures, which could not be detected using conventional nonhyperpolarized solution NMR. SABRE enhancement of the pyridine substrate can be fully rendered only after removal of the COD moiety; failure to properly activate the catalyst in the presence of sufficient substrate can lead to irreversible deactivation consistent with oligomerization of the catalyst molecules. Following catalyst activation, results from selective RF-saturation studies support the hypothesis that substrate polarization at high field arises from nuclear cross-relaxation with hyperpolarized (1)H spins of the hydride/orthohydrogen spin bath. Importantly, the chemical changes that accompanied the catalyst's full activation were also found to endow the catalyst with water solubility, here used to demonstrate SABRE hyperpolarization of nicotinamide in water without the need for any organic cosolvent--paving the way to various biomedical applications of SABRE hyperpolarization methods.

  14. Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange.

    Science.gov (United States)

    Burns, Michael C; Sun, Qi; Daniels, R Nathan; Camper, DeMarco; Kennedy, J Phillip; Phan, Jason; Olejniczak, Edward T; Lee, Taekyu; Waterson, Alex G; Rossanese, Olivia W; Fesik, Stephen W

    2014-03-01

    Aberrant activation of the small GTPase Ras by oncogenic mutation or constitutively active upstream receptor tyrosine kinases results in the deregulation of cellular signals governing growth and survival in ∼30% of all human cancers. However, the discovery of potent inhibitors of Ras has been difficult to achieve. Here, we report the identification of small molecules that bind to a unique pocket on the Ras:Son of Sevenless (SOS):Ras complex, increase the rate of SOS-catalyzed nucleotide exchange in vitro, and modulate Ras signaling pathways in cells. X-ray crystallography of Ras:SOS:Ras in complex with these molecules reveals that the compounds bind in a hydrophobic pocket in the CDC25 domain of SOS adjacent to the Switch II region of Ras. The structure-activity relationships exhibited by these compounds can be rationalized on the basis of multiple X-ray cocrystal structures. Mutational analyses confirmed the functional relevance of this binding site and showed it to be essential for compound activity. These molecules increase Ras-GTP levels and disrupt MAPK and PI3K signaling in cells at low micromolar concentrations. These small molecules represent tools to study the acute activation of Ras and highlight a pocket on SOS that may be exploited to modulate Ras signaling.

  15. The Guanine Nucleotide Exchange Factor ARNO mediates the activation of ARF and phospholipase D by insulin

    Directory of Open Access Journals (Sweden)

    Fluharty Eric

    2003-09-01

    Full Text Available Abstract Background Phospholipase D (PLD is involved in many signaling pathways. In most systems, the activity of PLD is primarily regulated by the members of the ADP-Ribosylation Factor (ARF family of GTPases, but the mechanism of activation of PLD and ARF by extracellular signals has not been fully established. Here we tested the hypothesis that ARF-guanine nucleotide exchange factors (ARF-GEFs of the cytohesin/ARNO family mediate the activation of ARF and PLD by insulin. Results Wild type ARNO transiently transfected in HIRcB cells was translocated to the plasma membrane in an insulin-dependent manner and promoted the translocation of ARF to the membranes. ARNO mutants: ΔCC-ARNO and CC-ARNO were partially translocated to the membranes while ΔPH-ARNO and PH-ARNO could not be translocated to the membranes. Sec7 domain mutants of ARNO did not facilitate the ARF translocation. Overexpression of wild type ARNO significantly increased insulin-stimulated PLD activity, and mutations in the Sec7 and PH domains, or deletion of the PH or CC domains inhibited the effects of insulin. Conclusions Small ARF-GEFs of the cytohesin/ARNO family mediate the activation of ARF and PLD by the insulin receptor.

  16. Active, Non-Intrusive Inspection Technologies for Homeland Defense

    Energy Technology Data Exchange (ETDEWEB)

    James L. Jones

    2003-06-01

    Active, non-intrusive inspection or interrogation technologies have been used for 100 years - with the primary focus being radiographic imaging. During the last 50 years, various active interrogation systems have been investigated and most have revealed many unique and interesting capabilities and advantages that have already benefited the general public. Unfortunately, except for medical and specific industrial applications, these unique capabilities have not been widely adopted, largely due to the complexity of the technology, the overconfident reliance on passive detection systems to handle most challenges, and the unrealistic public concerns regarding radiation safety issues for a given active inspection deployment. The unique homeland security challenges facing the United States today are inviting more "out-of-the-box" solutions and are demanding the effective technological solutions that only active interrogation systems can provide. While revolutionary new solutions are always desired, these technology advancements are rare, and when found, usually take a long time to fully understand and implement for a given application. What's becoming more evident is that focusing on under-developed, but well-understood, active inspection technologies can provide many of the needed "out-of-the-box" solutions. This paper presents a brief historical overview of active interrogation. It identifies some of the major homeland defense challenges being confronted and the commercial and research technologies presently available and being pursued. Finally, the paper addresses the role of the Idaho National Engineering and Environmental Laboratory and its partner, the Idaho Accelerator Center at Idaho State University, in promoting and developing active inspection technologies for homeland defense.

  17. 离子交换法提纯生育酚的实验方法%Experiment Method of Purification of Mixed Tocopherols by Ion Exchange Technology

    Institute of Scientific and Technical Information of China (English)

    陈明杰; 危凤

    2012-01-01

    离子交换分离技术是一种高效的化工分离技术,因其具有优异的分离选择性和操作方便等特点,广泛应用于水处理、湿法冶金、生化提取等行业。本文通过离子交换法提纯生育酚的实验教学实践,探讨了离子交换法提纯生育酚实验教学内容的设置,实验中通过柱层析技术、薄层色谱技术和高效液相色谱分析技术地综合运用,强化了学生的应用能力。%Ion exchange separation technology was an efficient separation technology, because of its excellent separa- tion selectivity and convenient operation, which was widely applied in water treatment, hydrometallurgy, and biochemical extraction. The experiment teaching of purification of tocopherols by ion exchange technology was introduced, and how to set up teaching content of ion exchange technology was explored. Through the integrated use of column chromatography technology, thin layer chromatography and high performance liquid chromatograph technology in the experiment, students'application abilities were strengthened.

  18. Modeling foreign exchange market activity around macroeconomic news: Hawkes-process approach

    Science.gov (United States)

    Rambaldi, Marcello; Pennesi, Paris; Lillo, Fabrizio

    2015-01-01

    We present a Hawkes-model approach to the foreign exchange market in which the high-frequency price dynamics is affected by a self-exciting mechanism and an exogenous component, generated by the pre-announced arrival of macroeconomic news. By focusing on time windows around the news announcement, we find that the model is able to capture the increase of trading activity after the news, both when the news has a sizable effect on volatility and when this effect is negligible, either because the news in not important or because the announcement is in line with the forecast by analysts. We extend the model by considering noncausal effects, due to the fact that the existence of the news (but not its content) is known by the market before the announcement.

  19. Active magnetic regenerator refrigeration with rotary multi-bed technology

    DEFF Research Database (Denmark)

    Eriksen, Dan

    Magnetic refrigeration is an emerging cooling technology with potential ad- vantages over conventional vapor compression, the most important being higher efficiency. This thesis presents experimental and theoretical research into the possibilities of realizing this potential with actual active...... with a thermal storage is introduced and demonstrated experimentally. Furthermore, a novel shunt valve technology, which was developed as a spin-off from the magnetic refrigeration research, is presented....

  20. An Activity Systems Theory Approach to Agent Technology

    OpenAIRE

    Zhang, Peng; Bai, Guohua

    2005-01-01

    In the last decade, Activity Theory has been discussed a lot in Human-Computer Interaction (HCI) and Computer Supported Cooperative Work (CSCW). Activity Theory was used both theoretically as an analytical method and practically as a development framework for Information Systems. Meanwhile, there is a new trench from Artificial Intelligence. Artificial Intelligence researchers find that the fruit from Activity Theory study may contribute, especially to Agent Technology, with socio-psychologic...

  1. Effect of Air Cleaning Technologies in Conjunction With the Use of Rotary Heat Exchangers in Residential Buildings

    DEFF Research Database (Denmark)

    Afshari, Alireza; Bergsøe, Niels Christian; Ekberg, Lars

    2013-01-01

    with rotary air-to-air heat exchangers. For this purpose, a mechanical filter with low pressure drop and a 4 cm thick activated carbon filter were selected for testing in a laboratory environment. The measurements included testing of the filters, separately and combined, in a ductwork to study the efficiency...... of the filters. The removal efficiency of the mechanical filter for ultrafine particles was examined using burning candles as sources for emission of particles. The measurements in the duct showed that the efficiency of the particle filter ranged between approximately 50% and 80% and the pressure loss...... of gases. The measurement results showed that the efficiency of the combined filters ranged between approximately 30% and 80% and the pressure loss was less than approximately 20 Pascal at an airflow rate of 250 m3/h....

  2. Disease Mutations in Rab7 Result in Unregulated Nucleotide Exchange and Inappropriate Activation

    Energy Technology Data Exchange (ETDEWEB)

    B McCray; E Skordalakes; J Taylor

    2011-12-31

    Rab GTPases are molecular switches that orchestrate vesicular trafficking, maturation and fusion by cycling between an active, GTP-bound form, and an inactive, GDP-bound form. The activity cycle is coupled to GTP hydrolysis and is tightly controlled by regulatory proteins. Missense mutations of the GTPase Rab7 cause a dominantly inherited axonal degeneration known as Charcot-Marie-Tooth type 2B through an unknown mechanism. We present the 2.8 A crystal structure of GTP-bound L129F mutant Rab7 which reveals normal conformations of the effector binding regions and catalytic site, but an alteration to the nucleotide binding pocket that is predicted to alter GTP binding. Through extensive biochemical analysis, we demonstrate that disease-associated mutations in Rab7 do not lead to an intrinsic GTPase defect, but permit unregulated nucleotide exchange leading to both excessive activation and hydrolysis-independent inactivation. Consistent with augmented activity, mutant Rab7 shows significantly enhanced interaction with a subset of effector proteins. In addition, dynamic imaging demonstrates that mutant Rab7 is abnormally retained on target membranes. However, we show that the increased activation of mutant Rab7 is counterbalanced by unregulated, GTP hydrolysis-independent membrane cycling. Notably, disease mutations are able to rescue the membrane cycling of a GTPase-deficient mutant. Thus, we demonstrate that disease mutations uncouple Rab7 from the spatial and temporal control normally imposed by regulatory proteins and cause disease not by a gain of novel toxic function, but by misregulation of native Rab7 activity.

  3. Bloom syndrome helicase stimulates RAD51 DNA strand exchange activity through a novel mechanism.

    Science.gov (United States)

    Bugreev, Dmitry V; Mazina, Olga M; Mazin, Alexander V

    2009-09-25

    Loss or inactivation of BLM, a helicase of the RecQ family, causes Bloom syndrome, a genetic disorder with a strong predisposition to cancer. Although the precise function of BLM remains unknown, genetic data has implicated BLM in the process of genetic recombination and DNA repair. Previously, we demonstrated that BLM can disrupt the RAD51-single-stranded DNA filament that promotes the initial steps of homologous recombination. However, this disruption occurs only if RAD51 is present in an inactive ADP-bound form. Here, we investigate interactions of BLM with the active ATP-bound form of the RAD51-single-stranded DNA filament. Surprisingly, we found that BLM stimulates DNA strand exchange activity of RAD51. In contrast to the helicase activity of BLM, this stimulation does not require ATP hydrolysis. These data suggest a novel BLM function that is stimulation of the RAD51 DNA pairing. Our results demonstrate the important role of the RAD51 nucleoprotein filament conformation in stimulation of DNA pairing by BLM.

  4. Sister chromatid exchange in human lymphocytes induced by propoxur following plant activation by Vicia faba.

    Science.gov (United States)

    Gómez-Arroyo, S; Calderón-Segura, M E; Villalobos-Pietrini, R

    1995-01-01

    Because the carbamate insecticide propoxur induced sister chromatid exchanges (SCE) in Vicia faba but was ineffective in producing SCE in lymphocytes in culture, it was hardly suspected that plant metabolism was involved. Experiments were conducted in which metabolic activation was afforded by Vicia faba roots, and SCE in human lymphocytes in vitro was used to assess cytogenetic damage. Several concentrations of propoxur (250, 500, 1,000, 1,500, and 2,000 ppm) were applied for 4 hr to the roots of Vicia faba. Extracts prepared from these treatments were added to the lymphocyte cultures and a significant increase of SCE frequencies with a concentration-response relationship could be detected. The lymphocyte proliferation kinetics and the proliferation rate index (PRI) were not affected (except in the highest concentration, of 2,000 ppm). This general behavior was in agreement with the presence of an enzymatic system (S10 fraction) in Vicia roots capable of metabolizing or activating the propoxur. With 2,000 ppm, cell necrosis was produced in Vicia; therefore, this extract did not induce SCE in lymphocytes. However, lymphocyte proliferation kinetics were delayed and PRI was significantly decreased. Ethanol, a promutagen activated by this plant, was applied directly to the lymphocyte cultures as a positive control, and the response was negative. On the other hand, the extracts of roots treated with ethanol increased the SCE to more than twice that of the negative control, but the lymphocyte proliferation kinetics and PRI were not affected.

  5. Automated entry technologies for confined space work activities: A survey.

    Science.gov (United States)

    Botti, Lucia; Ferrari, Emilio; Mora, Cristina

    2017-04-01

    Work in confined spaces poses a significant risk to workers and rescuers involved in the emergency response when an accident occurs. Despite several standards and regulations define the safety requirements for such activities, injuries, and fatalities still occur. Furthermore, the on-site inspections after accidents often reveal that both employers and employees fail to implement safe entry procedures. Removing the risk is possible by avoiding the worker entry, but many activities require the presence of the operator inside the confined space to perform manual tasks. The following study investigates the available technologies for hazardous confined space work activities, e.g., cleaning, inspecting, and maintenance tasks. The aim is to provide a systematic review of the automated solutions for high-risk activities in confined spaces, considering the non-man entry as the most effective confined space safety strategy. Second, this survey aims to provide suggestions for future research addressing the design of new technologies. The survey consists of about 60 papers concerning innovative technologies for confined space work activities. The document review shows that several solutions have been developed and automation can replace the workers for a limited number of hazardous tasks. Several activities still require the manual intervention due to the complex characteristics of confined spaces, e.g., to remove the remains of the automatic cleaning process from the bottom of a tank. The results show that available technologies require more flexibility to adapt to such occupational environments and further research is needed.

  6. Influences of microbial activity and sediment disturbance on hyporheic exchange in sandy sediments

    Science.gov (United States)

    Mendoza-Lera, C.; Mutz, M.

    2012-04-01

    Besides the vertical hydraulic gradient, sediment permeability is the main controlling factor of water exchange across the stream bed. Reduction of permeability by microbial activity is reported from unidirectional percolated sediment columns. We investigated effects of algal and bacterial activity on hyporheic exchange (vertical water flux, VWF) under semi-natural stream conditions in 16 outdoor sand-bed flumes during 30 day. Variability of bedform was considered by 8 flumes having plane-bed and 8 flumes ripple-bed. To gain information on the relative significance of algae and heterotrophic microorganisms, half of the flumes were operated under constant dark conditions (no-light flumes), while the others were exposed to daylight. After 21 days, the upper 2 cm of the sediments was manually disturbed simulating moderate sediment dynamics which frequently occurs in natural sand-bed streams. VWF was measured by tracing loss of uranine from the water column while flumes were operating in re-circulating mode. Algae and bacterial abundance, organic matter, and CaCO3 content in sediments were determined. Sediment potential respiration (SPR) was measured in flow through respiration chambers and oxygen bubbles from primary production were sampled. As expected, initial VWF was higher in ripple-bed. After 13 days, VWF was completely inhibited in both plane and ripple-bed flumes under daylight conditions. In no-light flumes reduction of VWF was moderate. Microbial precipitation of calcium carbonate and production of oxygen bubbles in the uppermost sediments blocked the pore space. After 3 weeks, abundance and biomass of algae and SPR in the upper 2 cm of sediment were higher in daylight flumes than in no-light flumes, while bacterial abundance was higher in no-light flumes. The sediment disturbance at day 21 released the oxygen bubbles increased bed permeability and therefore restored VWF to initial rates in day-light flumes. SPR was unaffected by the sediment disturbance. In

  7. Project to promote the development of global environmental industry technology. Feasibility study of research exchanges; Chikyu kankyo sangyo gijutsu kaihatsu suishin jigyo. Kenkyu koryu kanosei chosa

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-03-01

    In fiscal 1995, three teams were organized to study the following subjects: plant genetic and cellular engineering in relation to drought stress; simulation models of global environment for accurate assessment and prediction; the APEC Virtual Center for environmental technology exchange. The team studying plant genetic and cellular engineering in relation to drought stress visited the Department of Botany, Hebrew University of Jerusalem, Israel, the Jacob Blaustein Institute for Desert Research, Ben-Grunion University, Israel, the Department of Biochemistry and the Office of Arid Lands Studies, Arizona University, the U.S. to survey the present and future trend of the study and feasibility of research exchanges. The team studying simulation models of global environment for accurate assessment and prediction visited Yale University, Massachusetts Institute of Technology, Electric Power Research Institute, and Battle Research Institute in the U.S. to survey feasibility of research exchanges. The team studying the APEC Virtual Center for environmental technology exchange visited institutes in ASEAN countries to survey needs for the Virtual Center. 312 refs., 74 figs., 17 tabs.

  8. Reasoning about tasks, activities and technology to support collaboration.

    Science.gov (United States)

    Watts, L A; Monk, A F

    1998-11-01

    An aspect of collaboration described as 'semi-synchronized activity' is discussed as a particular challenge for the task analysis (TA) of collaborative work. TA typically involves the decomposition of work systems into essentially independent component processes between which commodities (information or materials) pass. In collaborative work, people routinely violate the condition of independence by moving seemlessly in and out of synchronization with one another, allowing for both independent and varying levels of conjoint activity. The shift between joint and independent projects is not fixed but managed through more or less explicit awareness of the other people over time. A number of case studies of the effect of communication technologies in telemedical consultation are drawn upon to illustrate the relationship between awareness and synchronization in collaborative work. They show that an analysis of collaborative activity requires a consideration of: (1) the activities constituting work; (2) the interactions between participants required to carry out the activities; (3) who else has access to these activities besides the primary participants in the ongoing work; (4) the contemporaneity of activities; (5) the locations/environments in which the activities are carried out; and (6) the constraints that apply to accessibility and participation within and between these environments. The Comms Usage Diagram is described as a framing notation incorporating these characteristics for a broad, communications-level analysis of collaborative activity. It shows how particular technologies relate to particular phases of work, indexing their effects to collaborative activities in those contexts.

  9. Catalytic activity of the mouse guanine nucleotide exchanger mSOS is activated by Fyn tyrosine protein kinase and the T-cell antigen receptor in T cells.

    OpenAIRE

    1996-01-01

    mSOS, a guanine nucleotide exchange factor, is a positive regulator of Ras. Fyn tyrosine protein kinase is a potential mediator in T-cell antigen receptor signal transduction in subsets of T cells. We investigated the functional and physical interaction between mSOS and Fyn in T-cell hybridoma cells. Stimulation of the T-cell antigen receptor induced the activation of guanine nucleotide exchange activity in mSOS immunoprecipitates. Overexpression of Fyn mutants with an activated kinase mutati...

  10. A status of the Turbine Technology Team activities

    Science.gov (United States)

    Griffin, Lisa W.

    1992-01-01

    The recent activities of the Turbine Technology Team of the Consortium for Computational Fluid Dynamics (CFD) Application in Propulsion Technology is presented. The team consists of members from the government, industry, and universities. The goal of this team is to demonstrate the benefits to the turbine design process attainable through the application of CFD. This goal is to be achieved by enhancing and validating turbine design tools for improved loading and flowfield definition and loss prediction, and transferring the advanced technology to the turbine design process. In order to demonstrate the advantages of using CFD early in the design phase, the Space Transportation Main Engine (STME) turbines for the National Launch System (NLS) were chosen on which to focus the team's efforts. The Turbine Team activities run parallel to the STME design work.

  11. Integrating Physical Activity Data Technologies into Elementary School Classrooms

    Science.gov (United States)

    Lee, Victor R.; Thomas, Jonathan M.

    2011-01-01

    This paper describes an iteration of a design-based research project that involved integrating commercial physical activity data (PAD) sensors, such as heart rate monitors and pedometers, as technologies that could be used in two fifth grade classrooms. By working in partnership with two participating teachers and seeking out immediate resources…

  12. SYNTHESIS OF METHYL TERT-BUTYL ETHER CATALYZED BY ACIDIC ION-EXCHANGE RESINS - INFLUENCE OF THE PROTON ACTIVITY

    NARCIS (Netherlands)

    PANNEMAN, HJ; BEENACKERS, AACM

    1995-01-01

    The catalytic activity of various strong acid ion-exchange resins on the synthesis of methyl tert-butyl ether (MtBE) from methanol and isobutene has been investigated. Relative to Amberlyst 15, Kastel CS 381 and Amberlyst CSP have similar rate constants, whereas Duolite ES 276 and Amberlyst XE 307 h

  13. Exchange Protein Activated by Cyclic AMP 2 (Epac2) Plays a Specific and Time-Limited Role in Memory Retrieval

    NARCIS (Netherlands)

    Ostroveanu, Anghelus; van der Zee, Eddy A.; Eisel, Ulrich L. M.; Schmidt, Martina; Nijholt, Ingrid M.

    2010-01-01

    Knowledge on the molecular mechanisms involved in memory retrieval is limited due to the lack of tools to study this stage of the memory process. Here we report that exchange proteins activated by cAMP (Epac) play a surprisingly specific role in memory retrieval. Intrahippocampal injection of the

  14. The technology - activities of daily living questionnaire: a version with a technology-related subscale.

    Science.gov (United States)

    Muñoz-Neira, Carlos; López, Oscar L; Riveros, Rodrigo; Núñez-Huasaf, Javier; Flores, Patricia; Slachevsky, Andrea

    2012-01-01

    Information and communication technology (ICT) has become an increasingly important part of daily life. The ability to use technology is becoming essential for autonomous functioning in society. Current functional scales for patients with cognitive impairment do not evaluate the use of technology. The objective of this study was to develop and validate a new version of the Activities of Daily Living Questionnaire (ADLQ) that incorporates an ICT subscale. A new technology-based subscale was incorporated into the Spanish version of the ADLQ (SV-ADLQ), entitled the Technology version of the ADLQ (T-ADLQ). The T-ADLQ was administered to 63 caregivers of dementia patients, 21 proxies of mild cognitive impairment patients and 44 proxies of normal elderly subjects (mean age of the sample ± SD: 73.5 ± 8.30 years). We analysed the convergent validity, internal consistency, reliability cut-off point, sensitivity and specificity of the T-ADLQ. The results of the T-ADLQ were compared to the SV-ADLQ. The T-ADLQ showed significant correlations with the Mini-Mental State Examination (MMSE), the Frontal Assessment Battery (FAB) as well as other measures of functional impairment and dementia severity (MMSE: r = -0.70; FAB: r = -0.65; Functional Assessment Questionnaire: r = 0.77; Instrumental Activities of Daily Living Scale: r = -0.75; Clinical Dementia Rating Scale: r = 0.72; p technology items in the T-ADLQ did not improve the performance of the scale, which may reflect the lack of widespread use of technology by elderly individuals. Thus, although it appeared reasonable to add technology use questions to the ADLQ, our experience suggested that this has to be done cautiously, since the sensitivity of these additional items could vary in different populations. The T-ADLQ needs to be validated in a different population of dementia subjects. Copyright © 2012 S. Karger AG, Basel.

  15. Active noise control technology. Active soon seigyo gijutsu

    Energy Technology Data Exchange (ETDEWEB)

    Eguchi, M.; Kokubo, F.; Tanaka, S.; Yao, K. (Sharp Corp., Osaka (Japan))

    1994-05-10

    The signal processing method of the Active Noise Control (ANC) system was studied. The principle of ANC is to output secondary sound waves having opposite phase, identical amplitude from the control point of the sound wave of the primary sound source, and eliminate the noise by interference. As application fields, there are air conditioner ducts and compressors as one dimensional noise source, and automobile and axial fan as three dimensional noise source. In order to improve the stability of coefficient renewal algorithm of Adaptive Digital Filter (ADF), for generation of opposite phase noise, DC-LMS algorithm which can control the rise in gain of specified frequency zone was proposed. Furthermore, with the purpose of reducing the amount of operation, the introduction of lattice type AR filter was tested for the stability of the filter in IIR-ADF (Infinite Impulse Response Adaptive Digital Filter) and its application process. The applicability studies of these improved methods on the noise inside of ducts were actually measured, and the effect was verified. For the multi-channel control of 3 dimensional noise source, reference scanning method to reduce the filter operation was proposed. In the partial space noise eliminating experiment, it was made clear that it possesses equivalent effect to error scanning method. 11 refs., 14 figs., 1 tab.

  16. On active disturbance rejection in temperature regulation of the proton exchange membrane fuel cells

    Science.gov (United States)

    Li, Dazi; Li, Chong; Gao, Zhiqiang; Jin, Qibing

    2015-06-01

    Operating a Proton Exchange Membrane fuel cell (PEMFC) system to maintain the stack temperature stable is one of the key issues in PEMFC's normal electrochemical reaction process. Its temperature characteristic is easily affected by inlet gas humidity, external disturbances, and electrical load changes and so on. Because of the complexity and nonlinearity of the reaction process, it is hard to build a model totally consistent with the real characteristic of the process. If model uncertainty, external disturbances, parameters changes can be regarded as "total disturbance", which is then estimated and compensated, the accurate model is no longer required and the control design can be greatly simplified to meet the practical needs. Based on this idea, an active disturbance rejection control (ADRC) with a switching law is proposed for the problem of precise temperature regulation in PEMFC. Results of the work show that the proposed control system allows the PEMFC to operate successfully at the temperature of 343 K point in the presence of two different disturbances.

  17. The United Nations Human Space Technology Initiative (HSTI): Science Activities

    CERN Document Server

    Niu, A; Haubold, H J; Doi, T

    2012-01-01

    The United Nations Human Space Technology Initiative (HSTI) aims at promoting international cooperation in human spaceflight and space exploration-related activities; creating awareness among countries on the benefits of utilizing human space technology and its applications; and building capacity in microgravity education and research. HSTI has been conducting various scientific activities to promote microgravity education and research. The primary science activity is called 'Zero-gravity Instrument Distribution Project', in which one-axis clinostats will be distributed worldwide. The distribution project will provide unique opportunities for students and researchers to observe the growth of indigenous plants in their countries in a simulated microgravity condition and is expected to create a huge dataset of plant species with their responses to gravity.

  18. The activities of HPPA technology related to ADS in China

    CERN Document Server

    Guan Xia Ling; Ding Da Zhao; Fang Jia Xun; Fang Shou Xian; Fu Shin Ian; Guo, Z Y; Jiang Wei; Li Jie Quan; Luo Zi Hua; Ouyang Hua Fu; Peng Chao Hua; Xu Tao Guang; Xu Wen Wu; Yu Qi; Zhang Zong Hua; Zhao Sheng Chu

    2001-01-01

    High Power Proton Accelerator (HPPA) is being studied all over world for numerous applications, which includes the waste transmutation, spallation neutron source and material irradiation facilities. In China, a multi-purpose verification system as a first phase of Chinese ADS program consists of a low energy accelerator (150 MeV/3 mA proton linac) and a swimming pool light water sub-critical reactor. The activities of HPPA technology related to ADS in China, which includes the intense proton ECR source, the RFQ accelerator and some other technology of HPPA, are described

  19. Designing Technology for Active Spectator Experiences at Sporting Events

    DEFF Research Database (Denmark)

    Veerasawmy, Rune; Ludvigsen, Martin

    2010-01-01

    behaviour in the context. The work presented also argues for a need to overcome the inclination to designing technological systems that imitate or compete with the experience of watching the television broadcast of the game. Experiments such as the presented BannerBattle are cornerstones in our exploratory......This paper explores the active spectator experience at sporting events, by presenting and reflecting upon a design experiment carried out at a number of football1 events. The initial hypothesis of the design process, leading to the design experiment has been that the spectator experience...... research-through-design approach to designing technologies for social experiences....

  20. Novel Chemically Stable Er3+-Yb3+ Codopded Phosphate Glass for Ion-Exchanged Active Waveguide Devices

    Institute of Scientific and Technical Information of China (English)

    陈宝玉; 赵士龙; 胡丽丽

    2003-01-01

    A novel Er3+-Yb3+ codoped phosphate glass,which combines good chemical durability with good spectroscopic properties,is developed for the ion-exchange process.The relevant properties of this glass are presented for reference in the design and modelling of ion-exchanged active waveguide devices.The weight-loss rate of this glass is 1.45 × 10-5 g.cm-2.h-1 in boiling water,which is comparable to that of Kigre's Q-246 silicate glass.The emission cross section of Er3+ in this glass is calculated to be 0.72 × 10-20 cm2 using the McCumber theory.It is found that a planar waveguide with three modes at 632.8 nm is readily realized in this glass from our primary ion-exchange experiments.

  1. Cu2Se and Cu Nanocrystals as Local Sources of Copper in Thermally Activated In Situ Cation Exchange

    KAUST Repository

    Casu, Alberto

    2016-01-27

    Among the different synthesis approaches to colloidal nanocrystals a recently developed toolkit is represented by cation exchange reactions, where the use of template nanocrystals gives access to materials that would be hardly attainable via direct synthesis. Besides, post-synthetic treatments, such as thermally activated solid state reactions, represent a further flourishing route to promote finely controlled cation exchange. Here, we report that, upon in situ heating in a transmission electron microscope, Cu2Se nanocrystals deposited on an amorphous solid substrate undergo partial loss of Cu atoms, which are then engaged in local cation exchange reactions with Cu “acceptors” phases represented by rod- and wire- shaped CdSe nanocrystals. This thermal treatment slowly transforms the initial CdSe nanocrystals into Cu2-xSe nanocrystals, through the complete sublimation of Cd and the partial sublimation of Se atoms. Both Cu “donor” and “acceptor” particles were not always in direct contact with each other, hence the gradual transfer of Cu species from Cu2Se or metallic Cu to CdSe nanocrystals was mediated by the substrate and depended on the distance between the donor and acceptor nanostructures. Differently from what happens in the comparably faster cation exchange reactions performed in liquid solution, this study shows that slow cation exchange reactions can be performed at the solid state, and helps to shed light on the intermediate steps involved in such reactions.

  2. Extravehicular Activity (EVA) Technology Development Status and Forecast

    Science.gov (United States)

    Chullen, Cinda; Westheimer, David T.

    2010-01-01

    Beginning in Fiscal Year (FY) 2011, Extravehicular activity (EVA) technology development became a technology foundational domain under a new program Enabling Technology Development and Demonstration. The goal of the EVA technology effort is to further develop technologies that will be used to demonstrate a robust EVA system that has application for a variety of future missions including microgravity and surface EVA. Overall the objectives will be reduce system mass, reduce consumables and maintenance, increase EVA hardware robustness and life, increase crew member efficiency and autonomy, and enable rapid vehicle egress and ingress. Over the past several years, NASA realized a tremendous increase in EVA system development as part of the Exploration Technology Development Program and the Constellation Program. The evident demand for efficient and reliable EVA technologies, particularly regenerable technologies was apparent under these former programs and will continue to be needed as future mission opportunities arise. The technological need for EVA in space has been realized over the last several decades by the Gemini, Apollo, Skylab, Space Shuttle, and the International Space Station (ISS) programs. EVAs were critical to the success of these programs. Now with the ISS extension to 2028 in conjunction with a current forecasted need of at least eight EVAs per year, the EVA technology life and limited availability of the EMUs will become a critical issue eventually. The current Extravehicular Mobility Unit (EMU) has vastly served EVA demands by performing critical operations to assemble the ISS and provide repairs of satellites such as the Hubble Space Telescope. However, as the life of ISS and the vision for future mission opportunities are realized, a new EVA systems capability could be an option for the future mission applications building off of the technology development over the last several years. Besides ISS, potential mission applications include EVAs for

  3. IN SITU REMEDIATION OF CONTAMINATED SEDIMENTS - ACTIVE CAPPING TECHNOLOGY

    Energy Technology Data Exchange (ETDEWEB)

    Knox, A.; Roberts, J.; Paller, M.; Reible, D.

    2010-09-02

    Active capping is a relatively new approach for treating contaminated sediments. It involves applying chemically reactive amendments to the sediment surface. The main role of active caps is to stabilize contaminants in contaminated sediments, lower the bioavailable pool of contaminants, and reduce the release of contaminants to the water column. Metals are common contaminants in many marine and fresh water environments as a result of industrial and military activities. The mobile, soluble forms of metals are generally considered toxic. Induced chemical precipitation of these metals can shift toxic metals from the aqueous phase to a solid, precipitated phase which is often less bioavailable. This approach can be achieved through application of sequestering agents such as rock phosphates, organoclays, zeolites, clay minerals, and biopolymers (e.g., chitosan) in active capping technology. Active capping holds great potential for a more permanent solution that avoids residual risks resulting from contaminant migration through the cap or breaching of the cap. In addition to identifying superior active capping agents, research is needed to optimize application techniques, application rates, and amendment combinations that maximize sequestration of contaminants. A selected set of active capping treatment technologies has been demonstrated at a few sites, including a field demonstration at the Savannah River Site, Aiken, SC. This demonstration has provided useful information on the effects of sequestering agents on metal immobilization, bioavailability, toxicity, and resistance to mechanical disturbance.

  4. [The NAS system: Nursing Activities Score in mobile technology].

    Science.gov (United States)

    Catalan, Vanessa Menezes; Silveira, Denise Tolfo; Neutzling, Agnes Ludwig; Martinato, Luísa Helena Machado; Borges, Gilberto Cabral de Mello

    2011-12-01

    The objective of this study was to present the computerized structure that enables the use of the Nursing Activities Score (NAS) in mobile technology. It is a project for the development of technology production based on software engineering, founded on the theory of systems development life cycle. The NAS system was built in two modules: the search module, which is accessed using a personal computer (PC), and Data Collection module, which is accessed through a mobile device (Smartphone). The NAS system was constructed to allow other forms, in addition to the NAS tool, to be included in the future. Thus, it is understood that the development of the NAS will bring nurses closer to mobile technology and facilitate their accessibility to the data of the instrument relating to patients, thus assisting in decision-making and in staffing to provide nursing care.

  5. Research Progress in Heat Transfer Enhancement Technology of Shell and Tube Heat Exchangers%管壳式换热器强化传热进展

    Institute of Scientific and Technical Information of China (English)

    张轮亭; 邱丽灿; 王臣

    2014-01-01

    管壳式换热器在石油化工领域应用广泛,其强化传热技术的研究受到普遍关注。主要介绍了近年来国内与国外高效节能管壳式换热器强化传热技术研究的进展情况,分别从管侧、壳侧和整体结构改进三方面分析了管壳式换热器的强化传热效果及特点,最后提出了强化传热的发展方向。%The tube and shell heat exchanger is widely used in the petrochemical field; research on the heat transfer enhancement technology is widely concerned. In this paper, research progress in the heat transfer enhancement technology of high efficiency shell and tube heat exchangers was introduced. From three aspects of the tube side, the shell side and the overall improvement, effect and features of the heat transfer enhancement of shell and tube heat exchangers were analyzed. At last, the development direction of the enhanced heat transfer technology was put forward.

  6. Dynamic positioning system based on active disturbance rejection technology

    Science.gov (United States)

    Lei, Zhengling; Guo, Chen; Fan, Yunsheng

    2015-08-01

    A dynamically positioned vessel, by the International Maritime Organization (IMO) and the certifying class societies (DNV, ABS, LR, etc.), is defined as a vessel that maintains its position and heading (fixed location or pre-determined track) exclusively by means of active thrusters. The development of control technology promotes the upgrading of dynamic positioning (DP) systems. Today there are two different DP systems solutions available on the market: DP system based on PID regulator and that based on model-based control. Both systems have limited disturbance rejection capability due to their design principle. In this paper, a new DP system solution is proposed based on Active Disturbance Rejection Control (ADRC) technology. This technology is composed of Tracking-Differentiator (TD), Extended State Observer (ESO) and Nonlinear Feedback Combination. On one hand, both TD and ESO can act as filters and can be used in place of conventional filters; on the other hand, the total disturbance of the system can be estimated and compensated by ESO, which therefore enhances the system's disturbance rejection capability. This technology's advantages over other methods lie in two aspects: 1) This method itself can not only achieve control objectives but also filter noisy measurements without other specialized filters; 2) This method offers a new useful approach to suppress the ocean disturbance. The simulation results demonstrate the effectiveness of the proposed method.

  7. The 'Technology - Activities of Daily Living Questionnaire': a version with a technology-related subscale

    Science.gov (United States)

    Muñoz-Neira, Carlos; López, Oscar L.; Riveros, Rodrigo; Nuñez-Huasaf, Javier; Flores, Patricia; Slachevsky, Andrea

    2016-01-01

    Background Information and communication technology (ICT) has become an increasingly important part of daily life. The ability to use technology is becoming essential for autonomous functioning in society. Current functional scales for patients with cognitive impairment do not evaluate the use of technology. The objective of this study was to develop and validate a new version of the Activities of Daily Living Questionnaire (ADLQ) that incorporates an ICT subscale. Method A new technology-based subscale was incorporated into the Spanish Version of the ADLQ (SV-ADLQ), entitled The Technology Version of the ADLQ (T-ADLQ). The T-ADLQ was administered to 63 caregivers of dementia patients, 21 proxies of mild cognitive impairment patients and 44 proxies of normal elderly subjects (mean age of the sample ± SD: 73.5 ± 8.30). We analysed the convergent validity, internal consistency, reliability cut-off point, sensitivity and specificity of the T-ADLQ. The results of the T-ADLQ were compared to the SV-ADLQ. Results The T-ADLQ showed significant correlations with the Mini-mental Test (MMSE), the Frontal Assesment Battery (FAB) as well as other measures of functional impairment and dementia severity (MMSE: r = −0.70; FAB: r = −0.65; Functional Assessment Questionnaire: r = 0.77; Instrumental Activities of Daily Living Scale: r = −0.75; Clinical Dementia Rating Scale: r = 0.72; p<0.001). The T-ADLQ showed a good reliability with a relatively high Cronbach’s alpha coefficient (Cronbach’s alpha = 0.861). When considering a functional impairment cut-off point greater than 29.25%, the sensitivity and specificity of the T-ADLQ were 82% and 90%, respectively. The area under the ROC curve (AUC) was 0.937 for the T-ADLQ and 0.932 for the original version of the test. Conclusions The T-ADLQ revealed adequate indicators of validity and reliability for the functional assessment of activities of daily living in dementia patients. However, the inclusion of technology items in

  8. [Studies on purgative activity of rhubarb extracts by different technologies].

    Science.gov (United States)

    Zheng, Zhihua; Zhu, Chenchen; Gui, Shuhua; Lin, Chaozhan

    2002-08-01

    To study on purgative activity of rhubarb extracts by solvent extraction, SFE-CO2 and SFE-CO2 & residue resin purification. The effects of the extracts by the three technologies on creepage of mouse small intestine and rat large intestine were studied by injecting charcoal ink into the intestines. And the volume of the mouse small intestine was observed. The effects of the extracts were also studied on water absorption of mouse small intestine and large intestine by weighing the intestines. The purgative activity of the extracts by the three technologies was SFE-CO2 & residue resin purification > solvent extraction > SFE-CO2. Extracting different polar components separately might get a good result.

  9. Designing Technology for Active Spectator Experiences at Sporting Events

    DEFF Research Database (Denmark)

    Veerasawmy, Rune; Ludvigsen, Martin

    is not merely an experience of receiving and consuming entertainment. It is also heavily reliant on the active participation of the spectator in creating the atmosphere of the entire event. The BannerBattle experiment provides interactive technology in sport arenas with a form of interaction based on existing......This paper explores the active spectator experience at sporting events, by presenting and reflecting upon a design experiment carried out at a number of football1 events. The initial hypothesis of the design process, leading to the design experiment has been that the spectator experience...... behaviour in the context. The work presented also argues for a need to overcome the inclination to designing technological systems that imitate or compete with the experience of watching the television broadcast of the game. Experiments such as the presented BannerBattle are cornerstones in our exploratory...

  10. Active magnetic radiation shielding system analysis and key technologies.

    Science.gov (United States)

    Washburn, S A; Blattnig, S R; Singleterry, R C; Westover, S C

    2015-01-01

    Many active magnetic shielding designs have been proposed in order to reduce the radiation exposure received by astronauts on long duration, deep space missions. While these designs are promising, they pose significant engineering challenges. This work presents a survey of the major systems required for such unconfined magnetic field design, allowing the identification of key technologies for future development. Basic mass calculations are developed for each system and are used to determine the resulting galactic cosmic radiation exposure for a generic solenoid design, using a range of magnetic field strength and thickness values, allowing some of the basic characteristics of such a design to be observed. This study focuses on a solenoid shaped, active magnetic shield design; however, many of the principles discussed are applicable regardless of the exact design configuration, particularly the key technologies cited.

  11. Joint research center activity in thermonuclear fusion technology

    Energy Technology Data Exchange (ETDEWEB)

    Casini, G.; Rocco, P. (Commission of the European Communities, Ispra (Italy). Joint Research Centre)

    1984-04-01

    A review of the activities in progress in the field of thermonuclear fusion technology at the Joint Research Centre of the European Communities is presented. The research areas are: (I) reactor studies, including conceptual design studies of experimental Tokamak reactors (INTOR/NET) and safety analyses; (II) experimental investigation on first wall and blanket materials and components. Emphasis has been given to those topics which are not reported in detail in the following articles of the issue.

  12. Process technology activities at the Software Engineering Institute

    Energy Technology Data Exchange (ETDEWEB)

    Christie, A.M. [Carnegie Mellon Univ., Pittsburgh, PA (United States)

    1996-12-31

    This paper provides a brief overview of the rationale for, and direction of the software process technology work being pursued at the Software Engineering Institute. The paper then describes some of the activities that the SEI has recently been involved in. Finally, it relates in more detail an example of one specific effort; namely the development of a process modeling formalism and its use in process simulation.

  13. FY 2000 international exchange project on exchanges of engineers - Coal mine technology field. Preliminary survey (Europe); 2000 nendo gijutsusha koryu jigyo (tanko gijutsu bun'ya) kokusai koryu jigyo. Jizen chosa (Oshu)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    For effective measures for technology transfer to developing countries and effective project on exchanges of engineers, survey was conducted for main European coal producing countries including Germany and the U.K. in terms of levels of coal technology and the trends, measures for technology transfer overseas, and the present situation of the coal industry. The results of the survey were classified into the following 7 items: 1) outline of the survey; 2) positioning of Germany and the U.K. in Europe; 3) coal industry in Germany; 4) coal technology in Germany; 5) coal industry in the U.K.; 6) coal technology in the U.K.; 7) coal industry in other European countries. 2) is composed of the coal situation in Europe, E.U.'s policy for aiding the coal industry of Germany, and the subsidy system of the U.K. E.U.'s coal consumption amount was 238 million Mtce in 1995, which was approximately 17% of the total energy consumption in the E.U. The coal production amount was 85 million Mtce in the E.U., 41 million Mtce in Germany and 30 million Mtce in the U.K. in 1999. Two-thirds of the consumption amount in the E.U. was import coal. (NEDO)

  14. Phosphorylation and activation of the plasma membrane Na+/H+ exchanger (NHE1 during osmotic cell shrinkage.

    Directory of Open Access Journals (Sweden)

    Robert R Rigor

    Full Text Available The Na(+/H(+Exchanger isoform 1 (NHE1 is a highly versatile, broadly distributed and precisely controlled transport protein that mediates volume and pH regulation in most cell types. NHE1 phosphorylation contributes to Na(+/H(+ exchange activity in response to phorbol esters, growth factors or protein phosphatase inhibitors, but has not been observed during activation by osmotic cell shrinkage (OCS. We examined the role of NHE1 phosphorylation during activation by OCS, using an ideal model system, the Amphiuma tridactylum red blood cell (atRBC. Na(+/H(+ exchange in atRBCs is mediated by an NHE1 homolog (atNHE1 that is 79% identical to human NHE1 at the amino acid level. NHE1 activity in atRBCs is exceptionally robust in that transport activity can increase more than 2 orders of magnitude from rest to full activation. Michaelis-Menten transport kinetics indicates that either OCS or treatment with the phosphatase inhibitor calyculin-A (CLA increase Na(+ transport capacity without affecting transport affinity (K(m=44 mM in atRBCs. CLA and OCS act non-additively to activate atNHE1, indicating convergent, phosphorylation-dependent signaling in atNHE1 activation. In situ(32P labeling and immunoprecipitation demonstrates that the net phosphorylation of atNHE1 is increased 4-fold during OCS coinciding with a more than 2-order increase in Na(+ transport activity. This is the first reported evidence of increased NHE1 phosphorylation during OCS in any vertebrate cell type. Finally, liquid chromatography and mass spectrometry (LC-MS/MS analysis of atNHE1 immunoprecipitated from atRBC membranes reveals 9 phosphorylated serine/threonine residues, suggesting that activation of atNHE1 involves multiple phosphorylation and/or dephosphorylation events.

  15. Numerical Analysis of Heat Transfer and Fluid Flow in Heat Exchangers with Emphasis on Pin Fin Technology

    OpenAIRE

    2012-01-01

    One of the most important industrial processes is heat transfer, carried out by heat exchangers in single and multiphase flow applications. Despite the existence of well-developed theoretical models for different heat transfer mechanisms, the expanding need for industrial applications requiring the design and optimization of heat exchangers, has created a solid demand for experimental work and effort. This thesis concerns the use of numerical approaches to analyze and optimize heat transfer a...

  16. Impact of active controls technology on structural integrity

    Science.gov (United States)

    Noll, Thomas; Austin, Edward; Donley, Shawn; Graham, George; Harris, Terry

    1991-01-01

    This paper summarizes the findings of The Technical Cooperation Program to assess the impact of active controls technology on the structural integrity of aeronautical vehicles and to evaluate the present state-of-the-art for predicting the loads caused by a flight-control system modification and the resulting change in the fatigue life of the flight vehicle. The potential for active controls to adversely affect structural integrity is described, and load predictions obtained using two state-of-the-art analytical methods are given.

  17. Fe3+-Exchanged Titanate Nanotubes: A New Kind of Highly Active Heterogeneous Catalyst for Friedel-Crafts Type Benzylation

    Directory of Open Access Journals (Sweden)

    Yunchen Du

    2015-01-01

    Full Text Available Heterogeneous catalysis for Friedel-Crafts type benzylation has received much attention in recent years due to its characteristic of environmental benefits. In this paper, titanate nanotubes (TNTs were employed as heterogeneous catalyst support, and a new kind of Fe3+-exchanged titanate nanotubes (Fe-TNTs catalyst with highly dispersed ferric sites was constructed by an ion exchange technique. The obtained catalyst was systematically characterized by XRD, TEM, N2 adsorption, XPS, and UV-vis spectra. As expected, Fe-TNTs showed excellent catalytic activities in the benzylation of benzene and benzene derivatives. The recycling tests for Fe-TNTs were also carried out, where the reason for the gradually decreased activity was carefully investigated. Superior to some reported catalysts, the catalytic ability of used Fe-TNTs could be easily recovered by ion exchange again, indicating that Fe-TNTs herein were a highly active and durable heterogeneous catalyst for Friedel-Crafts type benzylation. These results might be helpful for the design and preparation of novel heterogeneous catalysts by combining the structural advantages of titanate nanotubes and active metal ions.

  18. Exchange Protein Activated by cAMP Enhances Long-Term Memory Formation Independent of Protein Kinase A

    Science.gov (United States)

    Ma, Nan; Abel, Ted; Hernandez, Pepe J.

    2009-01-01

    It is well established that cAMP signaling within neurons plays a major role in the formation of long-term memories--signaling thought to proceed through protein kinase A (PKA). However, here we show that exchange protein activated by cAMP (Epac) is able to enhance the formation of long-term memory in the hippocampus and appears to do so…

  19. Development of Heat Exchanger Plate Based on Digital Manufacture Technology%基于数字制造技术的热交换器板片开发

    Institute of Scientific and Technical Information of China (English)

    王新; 胡国栋; 常春梅; 赵亮; 王忠; 殷建刚; 姚小毅

    2012-01-01

    热交换器板片是换热器中的主要换热元件,采用传统板片开发方法的模具返修率较高,尤其是超大型板片的开发.数字制造技术充分利用了计算技术的优势,将传统方法中的样板试制、模具改造两个环节集成为数字制造,使模具的返修变为几何模型的修改,从而极大提高了成形板片的冲压质量和使用性能.%Heat exchanger plate is the main heat-exchange components in the heat exchanger. The method of traditional development plate of the molds is more likely to repair, especially in the development of super large plate. The digital manufacturing technology made full use of the advantages of the computing technology, and integrated the traditional method of making samples and repairing molds are more likely to the digital manufacturing process, and transformed repairing mould to modifying geometric model, thus greatly increase quality and performance of the stamping plate.

  20. Chinese Commission of Science Technology and Industry for National Defense Senior Vice Minister CHEN Qiufa exchanging gifts at luncheon and signing the Guest Book on 1st November 2007 with CERN Director-General R. Aymar.

    CERN Multimedia

    Maximilien Brice

    2007-01-01

    Chinese Commission of Science Technology and Industry for National Defense Senior Vice Minister CHEN Qiufa exchanging gifts at luncheon and signing the Guest Book on 1st November 2007 with CERN Director-General R. Aymar.

  1. Information technology - Telecommunications and information exchange between systems - High-level data link control procedures - Description of the X.25 LAPB-compatible DTE data link procedures; Amendment 1: Modulo 32768 and multi-selective reject option

    CERN Document Server

    International Organization for Standardization. Geneva

    1996-01-01

    Information technology - Telecommunications and information exchange between systems - High-level data link control procedures - Description of the X.25 LAPB-compatible DTE data link procedures; Amendment 1: Modulo 32768 and multi-selective reject option

  2. An Exchange Structure Analysis of the Development of Online Intercultural Activity

    Science.gov (United States)

    Kitade, Keiko

    2012-01-01

    Internet-mediated intercultural discussions have been adopted for intercultural and second-language learning. However, the notion of community development in this context has received less attention. This study employs exchange structure (ES) analysis (Stubbs, M. (1983). "Discourse analysis." Oxford: Basil Blackwell) to investigate the dialogic…

  3. Friendship Activities in Brief——Sixth China-Japan-Korea Local Government Exchange Meeting

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    Invited by the Council of Local Authorities for International Relations of Japan,a 50-member Chinese delegation headed by Wang Yunze,vice president of the CPAFFC and the China International Friendship Cities Association attended the Sixth China-Japan-Korea Local Government Exchange Meeting in Niigata,

  4. SERS-active nanoparticle aggregate technology for tags and seals

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Leif O [Los Alamos National Laboratory; Montoya, Velma M [Los Alamos National Laboratory; Havrilla, George J [Los Alamos National Laboratory; Doorn, Stephen K [Los Alamos National Laboratory

    2010-06-03

    In this paper, we describe our efforts to create a modern tagging and sealing technology for international safeguards application. Our passive tagging methods are based on SANAs (SERS-Active Nanoparticle Aggregates; SERS: Surface Enhanced Raman Scattering). These SANAs offer robust spectral barcoding capability in an inexpensive tag/seal, with the possibility of rapid in-field verification that requires no human input. At INMM 2009, we introduced SANAs, and showed approaches to integrating our technology with tags under development at Sandia National Laboratories (SNL). Here, we will focus on recent LANL development work, as well as adding additional dimensionality to the barcoding technique. The field of international safeguards employs a broad array of tags, seals, and tamper-indicating devices to assist with identification, tracking, and verification of components and materials. These devices each have unique strengths suited to specific applications, and span a range of technologies from passive metal cup seals and adhesive seals to active, remotely monitored fiber optic seals. Regardless of the technology employed, essential characteristics center around security, environmental and temporal stability, ease of use, and the ability to provide confidence to all parties. Here, we present a new inexpensive tagging technology that will deliver these attributes, while forming the basis of either a new seal, or as a secure layer added to many existing devices. Our approach uses the Surface Enhanced Raman Scattering (SERS) response from SANAs (SERS-Active Nanoparticle Aggregates, Figure 1) to provide a unique identifier or signature for tagging applications. SANAs are formed from gold or silver nanoparticles in the 40-80 nm size range. A chemical dye is installed on the nanoparticle surface, and the nanoparticles are then aggregated into ensembles of {approx}100 to 500 nm diameter, prior to being coated with silica. The silica shell protects the finished SANA from

  5. Development of long-lived radionuclide partitioning technology - Preparation of ion exchanges for selective separation of radioactive elements

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Si Joong; Jeong, Hae In; Shim, Min Sook [Korea University, Seoul (Korea, Republic of); Kim, Jeong [Seonam University, Namwon (Korea, Republic of)

    1995-07-01

    Ion exchanger contained nitrogen-oxygen donor macrocyclic units was synthesized, and immobilization process was carried out by adsorption of the exchanger to silica gel. The binding constants were measured with acid concentration. From the binding constants, selectivity for Pt(II) ion and acid concentration of eluents were determined. The most optimum conditions for the separation were also determined from investigating the effects of amount of immobile phase and column length. And liarit aza-crown ethers were synthesized and selectively separated Cs/Sr ion from mixed metal solution. 37= refs., 24 tabs., 40 figs. (author)

  6. Tubular Ridge Surfaces with Intensified Heat Exchange and Technology of Their Manufacturing for Air Coolers of Fuel and Energy Complex

    Directory of Open Access Journals (Sweden)

    V. Кuntysh

    2013-01-01

    Full Text Available The paper presents designs of bimetallic ridge pipes (BRP with spirally-wound aluminium KLM-edges for heat exchange air coolers. Heat exchange BRP differ from the applied ones in heat-transfer coefficient which is higher by 10–15 %, extended temperature of applicability up to 320 °С for a cooled heat carrier at the pipe input, higher thermal reliability at alternating thermal burdens, current consumption for their manufacturing which is less by 1.8–2.5-fold, aluminium consumption which is less up to 1.8-fold, manufacturability in batch production,  availability high-production equipment.

  7. Multilevel Security Oriented Cross Domain Exchange Technology%面向多级安全的跨域交换技术研究

    Institute of Scientific and Technical Information of China (English)

    肖柳林

    2014-01-01

    跨域交换技术为不同安全域之间的数据通信提供了便利,但由于跨域信息系统开放了域内多个端口,面临着各种来自系统内外部的安全威胁,导致了信任危机。针对现有跨域信息系统在数据交换方面的安全需求,首先分析了当前跨域信息交换存在的问题,接着设计了面向多级安全的跨域交换系统架构,该架构能够有效地实现多域信息系统的安全互联与资源共享,然后研究了安全标签绑定、内容过滤等关键技术,最后对下一步的研究工作进行了展望。%Cross domain exchange technology provides a convenience for data communication between dif-ferent security domains. However, due to a number of opened ports of cross domain information systems, it faces various security threats from internal and external system, leading to a crisis of confidence. Aiming at the existing cross domain information system security requirements in terms of data exchange, this paper firstly analyzes the current problems of cross domain exchange of information, and then proposes multilevel security architecture of the cross domain exchange system, which can effectively implement secure inter-connection and resource sharing in the multi domain information system. Moreover, security label binding and content filtering technologies are studied. Finally, the next research jobs are discussed.

  8. Augmented cystine-glutamate exchange by pituitary adenylate cyclase-activating polypeptide signaling via the VPAC1 receptor

    Science.gov (United States)

    Resch, Jon M.; Albano, Rebecca; Liu, XiaoQian; Hjelmhaug, Julie; Lobner, Doug; Baker, David A.; Choi, SuJean

    2014-01-01

    In the central nervous system, cystine import in exchange for glutamate through system xc− is critical for the production of the antioxidant glutathione by astrocytes, as well as the maintenance of extracellular glutamate. Therefore, regulation of system xc− activity affects multiple aspects of cellular physiology and may contribute to disease states. Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuronally-derived peptide that has already been demonstrated to modulate multiple aspects of glutamate signaling suggesting PACAP may also target activity of cystine-glutamate exchange via system xc−. In the current study, 24-hour treatment of primary cortical cultures containing neurons and glia with PACAP concentration-dependently increased system xc− function as measured by radiolabeled cystine uptake. Furthermore, the increase in cystine uptake was completely abolished by the system xc− inhibitor, (S)-4-carboxyphenylglycine (CPG), attributing increases in cystine uptake specifically to system xc− activity. Time course and quantitative PCR results indicate that PACAP signaling may increase cystine-glutamate exchange by increasing expression of xCT, the catalytic subunit of system xc−. Furthermore, the potentiation of system xc− activity by PACAP occurs via a PKA-dependent pathway that is not mediated by the PAC1R, but rather the shared vasoactive intestinal polypeptide receptor VPAC1R. Finally, assessment of neuronal, astrocytic, and microglial-enriched cultures demonstrated that only astrocyte-enriched cultures exhibit enhanced cystine uptake following both PACAP and VIP treatment. These data introduce a novel mechanism by which both PACAP and VIP regulate system xc− activity. PMID:25066643

  9. Promoting Physical Activity through Hand-Held Computer Technology

    Science.gov (United States)

    King, Abby C.; Ahn, David K.; Oliveira, Brian M.; Atienza, Audie A.; Castro, Cynthia M.; Gardner, Christopher D.

    2009-01-01

    Background Efforts to achieve population-wide increases in walking and similar moderate-intensity physical activities potentially can be enhanced through relevant applications of state-of-the-art interactive communication technologies. Yet few systematic efforts to evaluate the efficacy of hand-held computers and similar devices for enhancing physical activity levels have occurred. The purpose of this first-generation study was to evaluate the efficacy of a hand-held computer (i.e., personal digital assistant [PDA]) for increasing moderate intensity or more vigorous (MOD+) physical activity levels over 8 weeks in mid-life and older adults relative to a standard information control arm. Design Randomized, controlled 8-week experiment. Data were collected in 2005 and analyzed in 2006-2007. Setting/Participants Community-based study of 37 healthy, initially underactive adults aged 50 years and older who were randomized and completed the 8-week study (intervention=19, control=18). Intervention Participants received an instructional session and a PDA programmed to monitor their physical activity levels twice per day and provide daily and weekly individualized feedback, goal setting, and support. Controls received standard, age-appropriate written physical activity educational materials. Main Outcome Measure Physical activity was assessed via the Community Healthy Activities Model Program for Seniors (CHAMPS) questionnaire at baseline and 8 weeks. Results Relative to controls, intervention participants reported significantly greater 8-week mean estimated caloric expenditure levels and minutes per week in MOD+ activity (p<0.04). Satisfaction with the PDA was reasonably high in this largely PDA-naive sample. Conclusions Results from this first-generation study indicate that hand-held computers may be effective tools for increasing initial physical activity levels among underactive adults. PMID:18201644

  10. Promoting physical activity through hand-held computer technology.

    Science.gov (United States)

    King, Abby C; Ahn, David K; Oliveira, Brian M; Atienza, Audie A; Castro, Cynthia M; Gardner, Christopher D

    2008-02-01

    Efforts to achieve population-wide increases in walking and similar moderate-intensity physical activities potentially can be enhanced through relevant applications of state-of-the-art interactive communication technologies. Yet few systematic efforts to evaluate the efficacy of hand-held computers and similar devices for enhancing physical activity levels have occurred. The purpose of this first-generation study was to evaluate the efficacy of a hand-held computer (i.e., personal digital assistant [PDA]) for increasing moderate intensity or more vigorous (MOD+) physical activity levels over 8 weeks in mid-life and older adults relative to a standard information control arm. Randomized, controlled 8-week experiment. Data were collected in 2005 and analyzed in 2006-2007. Community-based study of 37 healthy, initially underactive adults aged 50 years and older who were randomized and completed the 8-week study (intervention=19, control=18). Participants received an instructional session and a PDA programmed to monitor their physical activity levels twice per day and provide daily and weekly individualized feedback, goal setting, and support. Controls received standard, age-appropriate written physical activity educational materials. Physical activity was assessed via the Community Healthy Activities Model Program for Seniors (CHAMPS) questionnaire at baseline and 8 weeks. Relative to controls, intervention participants reported significantly greater 8-week mean estimated caloric expenditure levels and minutes per week in MOD+ activity (pfirst-generation study indicate that hand-held computers may be effective tools for increasing initial physical activity levels among underactive adults.

  11. Research on XML-based Application Layer Data Exchange Technology%基于XML的应用层数据交换技术的研究

    Institute of Scientific and Technical Information of China (English)

    尹建璋

    2009-01-01

    目前,许多企业已着力建立各种计算机应用以助于商业运营.虽然这带来了效率的显著提高,但它并没有扩展到企业外部的业务.这些业务涵盖不同公司企业应用或商业运营的交换和交流.很多情况下企业与它们的商业伙伴、供货商和客户存在信息孤岛.企业间以及它们与其商业伙伴间的交流仍旧是依赖人工处理,因此效率很低.电子数据交换(EDI)被认为是这一问题的解决方案,而应用层数据交换技术是该方案的重中之重,因此,本文主要对电子数据交换技术中的XML应用层数据交换技术进行研究.%At present, many enterprises have been efforts to establish a variety of computer applications in order to help business operators. While that has had a significant improvement in the efficiency, but it does not extend to companies outside the business. These businesses cover a variety of companies applications or business operations of the exchange and communication. Many cases, enterprises and their business partners, suppliers and customers there are islands of information. Between enterprises and their business partners and their exchanges are still dependent on manual processing, so efficiency is very low. Electronic Data Interchange (EDI) is considered to be the solution to this problem, and the application layer data exchange technology is the top priority of the program, this paper studies the electronic data exchange technology in application-level XML data exchange technology.

  12. Postassembly Transformation of a Catalytically Active Composite Material, Pt@ZIF-8, via Solvent-Assisted Linker Exchange.

    Science.gov (United States)

    Stephenson, Casey J; Hupp, Joseph T; Farha, Omar K

    2016-02-15

    2-Methylimidazolate linkers of Pt@ZIF-8 are exchanged with imidazolate using solvent-assisted linker exchange (SALE) to expand the apertures of the parent material and create Pt@SALEM-2. Characterization of the material before and after SALE was performed. Both materials are active as catalysts for the hydrogenation of 1-octene, whereas the hydrogenation of cis-cyclohexene occurred only with Pt@SALEM-2, consistent with larger apertures for the daughter material. The largest substrate, β-pinene, proved to be unreactive with H2 when either material was employed as a candidate catalyst, supporting the contention that substrate molecules, for both composites, must traverse the metal-organic framework component in order to reach the catalytic nanoparticles.

  13. Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange.

    Science.gov (United States)

    Oliver, Antony W; Paul, Angela; Boxall, Katherine J; Barrie, S Elaine; Aherne, G Wynne; Garrett, Michelle D; Mittnacht, Sibylle; Pearl, Laurence H

    2006-07-12

    The protein kinase Chk2 (checkpoint kinase 2) is a major effector of the replication checkpoint. Chk2 activation is initiated by phosphorylation of Thr68, in the serine-glutamine/threonine-glutamine cluster domain (SCD), by ATM. The phosphorylated SCD-segment binds to the FHA domain of a second Chk2 molecule, promoting dimerisation of the protein and triggering phosphorylation of the activation segment/T-loop in the kinase domain. We have now determined the structure of the kinase domain of human Chk2 in complexes with ADP and a small-molecule inhibitor debromohymenialdisine. The structure reveals a remarkable dimeric arrangement in which T-loops are exchanged between protomers, to form an active kinase conformation in trans. Biochemical data suggest that this dimer is the biologically active state promoted by ATM-phosphorylation, and also suggests a mechanism for dimerisation-driven activation of Chk2 by trans-phosphorylation.

  14. Evaluation and Certification of Ambersorb 4652 for use in Activated Carbon Ion Exchange Filters for the International Space Station

    Science.gov (United States)

    Adam, Niklas; Cox, Trey; Larner, Katherine; Carter, Donald; Kouba, Coy

    2017-01-01

    In order to reduce the infiltration of dimethylsilanediol (DMSD) and other organosilicon containing species through the Multifiltration Beds (MF Beds), an alternate activated carbon was found to replace the obsolete Barnabey Cheney 580-26 activated carbon. The carbon that removed the most organosilicon compounds in testing1 was a synthetic activated carbon named Schunk 4652 which later became Ambersorb 4652. Since activated carbon has a large capacity for iodine (I2), and is used in the Activated Carbon Ion Exchange (ACTEX) filters on the International Space Station (ISS), testing was performed on the Ambersorb 4652 carbon to determine the effectiveness of the material for use in ACTEX filters to remove iodine. This work summarizes the testing and the certification of Ambersorb 4652 for use in the ACTEX filters for the ISS.

  15. Active Shop Scheduling Of Production Process Based On RFID Technology

    Directory of Open Access Journals (Sweden)

    Cuihua Chao

    2016-01-01

    Full Text Available In industry 4.0 environment, intelligent technology is almost applied to all parts of the manufacturing process, such as process design, job shop scheduling, etc.. This paper presents an efficient approach to job shop scheduling actively by using RFID to collect real-time manufacturing data. Identified the workpiece by RFID which needs to be machined, it can “ask for” the resource actively for the following process. With these active asking-for strategy, a double genetically encoded improved genetic algorithm is proposed for achieving active job shop scheduling solution during the actual manufacturing process. A case was used to evaluate its effectiveness. Meanwhile, , it can effectively and actively carry out job shop scheduling and has much better convergence effect comparing with basic genetic algorithm. And the job shop scheduler in management center can use the proposed algorithm to get the satisfied scheduling result timely by reducing waiting time and making begin time earlier during transmission between manufacturing process, which makes the scheduling result feasible and accurate.

  16. CRISPR Technology for Genome Activation and Repression in Mammalian Cells.

    Science.gov (United States)

    Du, Dan; Qi, Lei S

    2016-01-04

    Targeted modulation of transcription is necessary for understanding complex gene networks and has great potential for medical and industrial applications. CRISPR is emerging as a powerful system for targeted genome activation and repression, in addition to its use in genome editing. This protocol describes how to design, construct, and experimentally validate the function of sequence-specific single guide RNAs (sgRNAs) for sequence-specific repression (CRISPRi) or activation (CRISPRa) of transcription in mammalian cells. In this technology, the CRISPR-associated protein Cas9 is catalytically deactivated (dCas9) to provide a general platform for RNA-guided DNA targeting of any locus in the genome. Fusion of dCas9 to effector domains with distinct regulatory functions enables stable and efficient transcriptional repression or activation in mammalian cells. Delivery of multiple sgRNAs further enables activation or repression of multiple genes. By using scaffold RNAs (scRNAs), different effectors can be recruited to different genes for simultaneous activation of some and repression of others. The CRISPRi and CRISPRa methods provide powerful tools for sequence-specific control of gene expression on a genome-wide scale to aid understanding gene functions and for engineering genetic regulatory systems.

  17. Multiple factors confer specific Cdc42 and Rac protein activation by dedicator of cytokinesis (DOCK) nucleotide exchange factors.

    Science.gov (United States)

    Kulkarni, Kiran; Yang, Jing; Zhang, Ziguo; Barford, David

    2011-07-15

    DOCK (dedicator of cytokinesis) guanine nucleotide exchange factors (GEFs) activate the Rho-family GTPases Rac and Cdc42 to control cell migration, morphogenesis, and phagocytosis. The DOCK A and B subfamilies activate Rac, whereas the DOCK D subfamily activates Cdc42. Nucleotide exchange is catalyzed by a conserved DHR2 domain (DOCK(DHR2)). Although the molecular basis for DOCK(DHR2)-mediated GTPase activation has been elucidated through structures of a DOCK9(DHR2)-Cdc42 complex, the factors determining recognition of specific GTPases are unknown. To understand the molecular basis for DOCK-GTPase specificity, we have determined the crystal structure of DOCK2(DHR2) in complex with Rac1. DOCK2(DHR2) and DOCK9(DHR2) exhibit similar tertiary structures and homodimer interfaces and share a conserved GTPase-activating mechanism. Multiple structural differences between DOCK2(DHR2) and DOCK9(DHR2) account for their selectivity toward Rac1 and Cdc42. Key determinants of selectivity of Cdc42 and Rac for their cognate DOCK(DHR2) are a Phe or Trp residue within β3 (residue 56) and the ability of DOCK proteins to exploit differences in the GEF-induced conformational changes of switch 1 dependent on a divergent residue at position 27. DOCK proteins, therefore, differ from DH-PH GEFs that select their cognate GTPases through recognition of structural differences within the β2/β3 strands.

  18. The development of enabling technologies for producing active interrogation beams

    Energy Technology Data Exchange (ETDEWEB)

    Kwan, Thomas J. T.; Morgado, Richard E.; Wang, Tai-Sen F. [Los Alamos National Laboratory, Los Alamos, New Mexico 87544 (United States); Vodolaga, B.; Terekhin, V. [All-Russia Scientific Research Institute of Technical Physics, Snezhinsk (Russian Federation); Onischenko, L. M.; Vorozhtsov, S. B.; Samsonov, E. V.; Vorozhtsov, A. S.; Alenitsky, Yu. G.; Perpelkin, E. E.; Glazov, A. A.; Novikov, D. L. [Joint Institute of Nuclear Research, Joliot-Curie 6, 141980 Dubna, Moscow Region (Russian Federation); Parkhomchuk, V.; Reva, V.; Vostrikov, V. [Budker Institute of Nuclear Physics (BINP), Av. Lavrent' ev, 630090 Novosibirsk (Russian Federation); Mashinin, V. A.; Fedotov, S. N.; Minayev, S. A. [Research Firm IFI, Moscow (Russian Federation)

    2010-10-15

    A U.S./Russian collaboration of accelerator scientists was directed to the development of high averaged-current ({approx}1 mA) and high-quality (emittance {approx}15 {pi}mm mrad; energy spread {approx}0.1%) 1.75 MeV proton beams to produce active interrogation beams that could be applied to counterterrorism. Several accelerator technologies were investigated. These included an electrostatic tandem accelerator of novel design, a compact cyclotron, and a storage ring with energy compensation and electron cooling. Production targets capable of withstanding the beam power levels were designed, fabricated, and tested. The cyclotron/storage-ring system was theoretically studied and computationally designed, and the electrostatic vacuum tandem accelerator at BINP was demonstrated for its potential in active interrogation of explosives and special nuclear materials.

  19. Development of HANARO Activation Analysis System and Utilization Technology

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Y. S.; Moon, J. H.; Cho, H. J. (and others)

    2007-06-15

    1. Establishment of evaluation system using a data for a neutron activation analysis : Improvement of NAA measurement system and its identification, Development of combined data evaluation code of NAA/PGAA, International technical cooperation project 2. Development of technique for a industrial application of high precision gamma nuclide spectroscopic analysis : Analytical quality control, Development of industrial application techniques and its identification 3. Industrial application research for a prompt gamma-ray activation analysis : Improvement of Compton suppression counting system (PGAA), Development of applied technology using a PGAA system 4. Establishment of NAA user supporting system and KOLAS management : Development and validation of KOLAS/ISO accreditation testing and identification method, Cooperation researches for a industrial application, Establishment of integrated user analytical supporting system, Accomplishment of sample irradiation facility.

  20. FY 2000 international exchange project on exchanges of engineers - Coal mine technology field. Overseas workshop (Indonesia); 2000 nendo gijutsusha koryu jigyo (tanko gijutsu bun'ya) kokusai koryu jigyo. Kaigai workshop (Indonesia)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    For the purpose of making effective technology exchanges and surveying levels of technology in Indonesia and the needs and possibilities of technology transfer from Japan, workshop was held in Jakarta city on March 1, 2001. Subjects were the following seven: subjects on coal resource and technical strategy in the 21st century, challenge in coal development in Indonesia, geological structure survey at Tanjung Enim coal mine, waste water treatment in Indonesia, outlook for underground mining coal mines, joint research on the centralized monitoring system, and introduction of the optimum high wall coal mining system into open pit mining coal mines in Indonesia. The coal production amount in Indonesia was 75 million tons, and the domestic demand was 22 million tons. Japan imported 14 million tons from Indonesia. In coal mines in Indonesia, most of the coal preparation plants have no waste water treatment facilities. Considering that waste water treatment facilities are necessary for the plants in future, the joint research was made on the simple coal preparation waste water treatment system. (NEDO)

  1. Converging technologies and de-perimeterisation: towards risky active insulation

    NARCIS (Netherlands)

    Pieters, Wolter

    In converging technologies (Roco and Bainbridge, 2003), boundaries between previously separated technologies become permeable. A similar process is also taking place within information technology. In what is called de-perimeterisation (Jericho Forum, 2005), the boundaries of the information

  2. Converging technologies and de-perimeterisation: towards risky active insulation

    NARCIS (Netherlands)

    Pieters, W.

    2009-01-01

    In converging technologies (Roco and Bainbridge, 2003), boundaries between previously separated technologies become permeable. A similar process is also taking place within information technology. In what is called de-perimeterisation (Jericho Forum, 2005), the boundaries of the information infrastr

  3. Maximum length sequence and Bessel diffusers using active technologies

    Science.gov (United States)

    Cox, Trevor J.; Avis, Mark R.; Xiao, Lejun

    2006-02-01

    Active technologies can enable room acoustic diffusers to operate over a wider bandwidth than passive devices, by extending the bass response. Active impedance control can be used to generate surface impedance distributions which cause wavefront dispersion, as opposed to the more normal absorptive or pressure-cancelling target functions. This paper details the development of two new types of active diffusers which are difficult, if not impossible, to make as passive wide-band structures. The first type is a maximum length sequence diffuser where the well depths are designed to be frequency dependent to avoid the critical frequencies present in the passive device, and so achieve performance over a finite-bandwidth. The second is a Bessel diffuser, which exploits concepts developed for transducer arrays to form a hybrid absorber-diffuser. Details of the designs are given, and measurements of scattering and impedance used to show that the active diffusers are operating correctly over a bandwidth of about 100 Hz to 1.1 kHz. Boundary element method simulation is used to show how more application-realistic arrays of these devices would behave.

  4. The Role of Cultural Exchange in Human Progress

    Institute of Scientific and Technical Information of China (English)

    1992-01-01

    Cultural exchanges are an important part of oursocial activities and have a great effect on theprogress and development of human society.In the process of human social development differ-ent nationalities created their own unique cultures.Be-cause of the development of different cultures in differ-ent countries,cultural exchanges become an attractiveproposition.Cultural exchanges have a positive and salubriouseffect on all nationalities,encouraging social develop-ment,economic prosperity and scientific and techno-logical progress.During cultural exchanges differentcountries in the world learn from each other,helpingthe different cultures develop and mature.

  5. A New Adsorbent Composite Material Based on Metal Fiber Technology and Its Application in Adsorption Heat Exchangers

    Directory of Open Access Journals (Sweden)

    Ursula Wittstadt

    2015-08-01

    Full Text Available In order to achieve process intensification for adsorption chillers and heat pumps, a new composite material was developed based on sintered aluminum fibers from a melt-extraction process and a dense layer of silico-aluminophosphate (SAPO-34 on the fiber surfaces. The SAPO-34 layer was obtained through a partial support transformation (PST process. Preparation of a composite sample is described and its characteristic pore size distribution and heat conductivity are presented. Water adsorption data obtained under conditions of a large pressure jump are given. In the next step, preparation of the composite was scaled up to larger samples which were fixed on a small adsorption heat exchanger. Adsorption measurements on this heat exchanger element that confirm the achieved process intensification are presented. The specific cooling power for the adsorption step per volume of composite is found to exceed 500 kW/m3 under specified conditions.

  6. Development of a transparent, non-cytotoxic, silver ion-exchanged glass with antimicrobial activity and low ion elution.

    Science.gov (United States)

    Shim, Gyu-In; Kim, Seong-Hwan; Eom, Hyung-Woo; Kim, Kwang-Mahn; Choi, Se-Young

    2015-05-01

    We investigated the antimicrobial, cytotoxicity, skin irritation, and ion elution behaviors of glass doped with silver ions with respect to its application to electronic equipment such as phones and tablet screens. The microbes tested were Escherichia coli, Staphylococcus aureus, and Penicillium funiculosum. AgNO3 powder was spread on both sides of aluminosilicate glass, and it was heated to 250-280°C for 10min. Under optimized heating conditions (260°C, 10min), the antimicrobial activity of ion-exchanged glass against bacteria and fungi was over 99.9% after 24 weeks. The glass failed to irritate the skin of experimental animals and was considered non-cytotoxic. The maximum amount of Ag ions that were eluted from the ion-exchanged glass into drinking water was measured at 0.037±0.003μgL(-1), an amount which is several orders of magnitude below the standard limit of 0.1mgL(-1) in drinking water. Ag ion-exchanged glass had characteristics suitable for use as a display screen, such as a light transmittance of 90% and a surface roughness of 0.704nm. Our findings suggest that glass doped with silver ions is more hygienic than non-doped glass is, and should be applied to display screens and glassware.

  7. Product technology and market assessment for silicon carbide whisker reinforced alumina heat-exchanger tubes. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Loutfy, R.O.; Withers, J.C. [Materials and Electrochemical Research Corp., Tucson, AZ (United States); Chakravarti, D. [Arizona Univ., Tucson, AZ (United States)

    1993-10-01

    This report describes a study designed to develop an assessment of key performance features, desirable technical specifications and market potential for silicon carbide whisker-reinforced alumina (henceforth SCWRA) tubes for heat exchanger applications in a number of industries. The results of the first stage of a Delphi study conducted in the US market are presented. The second phase of the study is in progress. The first stage results suggest that there is a small market for SCWRA tubes in heat exchanger applications. The market is expected to grow steadily during the 1990`s. With appropriate performance specifications and competitive pricing, growth should come from (a) new applications that permit recovery in cases that were previously infeasible and (b) selective, partial substitution and replacement of current ceramics and metal/ceramic composites in existing applications. We identify key performance factors and detailed specifications needed in six designated industries (primary metals, fabricated metals, chemicals, glass, utility and incinerators). Reliability, durability and low maintenance costs emerge as critical performance factors across these industries. The data show that although ceramics are recognized as having better properties, enhancing reliability and durability and thus improving maintenance cost performance is a key priority. Such improvements, reflected in the objectives for SCWRA tubes, should facilitate adoption in both new and existing applications. At this time, we are unable to assess market size directly. However, expert judgment provided indices tracking the projected market for heat exchanger tubes from 1990 to 2005.

  8. Performance of active vibration control technology: the ACTEX flight experiments

    Science.gov (United States)

    Nye, T. W.; Manning, R. A.; Qassim, K.

    1999-12-01

    This paper discusses the development and results of two intelligent structures space-flight experiments, each of which could affect architecture designs of future spacecraft. The first, the advanced controls technology experiment I (ACTEX I), is a variable stiffness tripod structure riding as a secondary payload on a classified spacecraft. It has been operating well past its expected life since becoming operational in 1996. Over 60 on-orbit experiments have been run on the ACTEX I flight experiment. These experiments form the basis for in-space controller design problems and for concluding lifetime/reliability data on the active control components. Transfer functions taken during the life of ACTEX I have shown consistent predictability and stability in structural behavior, including consistency with those measurements taken on the ground prior to a three year storage period and the launch event. ACTEX I can change its modal characteristics by employing its dynamic change mechanism that varies preloads in portions of its structure. Active control experiments have demonstrated maximum vibration reductions of 29 dB and 16 dB in the first two variable modes of the system, while operating over a remarkable on-orbit temperature range of -80 °C to 129 °C. The second experiment, ACTEX II, was successfully designed, ground-tested, and integrated on an experimental Department of Defense satellite prior to its loss during a launch vehicle failure in 1995. ACTEX II also had variable modal behavior by virtue of a two-axis gimbal and added challenges of structural flexibility by being a large deployable appendage. Although the loss of ACTEX II did not provide space environment experience, ground testing resulted in space qualifying the hardware and demonstrated 21 dB, 14 dB, and 8 dB reductions in amplitude of the first three primary structural modes. ACTEX II could use either active and/or passive techniques to affect vibration suppression. Both experiments trailblazed

  9. Role of exchange protein directly activated by cAMP (EPAC1) in breast cancer cell migration and apoptosis.

    Science.gov (United States)

    Kumar, Naveen; Gupta, Sonal; Dabral, Surbhi; Singh, Shailja; Sehrawat, Seema

    2017-02-16

    Despite the current progress in cancer research and therapy, breast cancer remains the leading cause of mortality among half a million women worldwide. Migration and invasion of cancer cells are associated with prevalent tumor metastasis as well as high mortality. Extensive studies have powerfully established the role of prototypic second messenger cAMP and its two ubiquitously expressed intracellular cAMP receptors namely the classic protein kinaseA/cAMP-dependent protein kinase (PKA) and the more recently discovered exchange protein directly activated by cAMP/cAMP-regulated guanine nucleotide exchange factor (EPAC/cAMP-GEF) in cell migration, cell cycle regulation, and cell death. Herein, we performed the analysis of the Cancer Genome Atlas (TCGA) dataset to evaluate the essential role of cAMP molecular network in breast cancer. We report that EPAC1, PKA, and AKAP9 along with other molecular partners are amplified in breast cancer patients, indicating the importance of this signaling network. To evaluate the functional role of few of these proteins, we used pharmacological modulators and analyzed their effect on cell migration and cell death in breast cancer cells. Hence, we report that inhibition of EPAC1 activity using pharmacological modulators leads to inhibition of cell migration and induces cell death. Additionally, we also observed that the inhibition of EPAC1 resulted in disruption of its association with the microtubule cytoskeleton and delocalization of AKAP9 from the centrosome as analyzed by in vitro imaging. Finally, this study suggests for the first time the mechanistic insights of mode of action of a primary cAMP-dependent sensor, Exchange protein activated by cAMP 1 (EPAC1), via its interaction with A-kinase anchoring protein 9 (AKAP9). This study provides a new cell signaling cAMP-EPAC1-AKAP9 direction to the development of additional biotherapeutics for breast cancer.

  10. Blocking of Exchange Proteins Directly Activated by cAMP Leads to Reduced Replication of Middle East Respiratory Syndrome Coronavirus

    Science.gov (United States)

    Tao, Xinrong; Mei, Feng; Agrawal, Anurodh; Peters, Clarence J.; Ksiazek, Thomas G.

    2014-01-01

    The outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infections and diseases represents a potential threat for worldwide spread and requires development of effective therapeutic strategies. In this study, we revealed a novel positive function of an exchange protein directly activated by cyclic AMP 1 (cAMP-1; Epac-1) on MERS-CoV replication. Specifically, we have shown that Epac-specific inhibitor treatment or silencing Epac-1 gene expression rendered cells resistant to viral infection. We believe Epac-1 inhibitors deserve further study as potential therapeutic agents for MERS-CoV infection. PMID:24453361

  11. Technological Innovation, R & D Activities and Innovation System Between Organizations

    Directory of Open Access Journals (Sweden)

    Jonas Pedro Fabris

    2015-08-01

    Full Text Available This theoretical paper aimed to explicit, through the rescue of theoretical assumptions, the innovation, the innovation system, and the research and development (R & D activities. The innovation, especially technological innovation, is now seen as essential in differentiation strategies, competitiveness and growth in a greater number of businesses. Innovation is not only the result of financial investments by companies. For it to exist, it is necessary the existence of innovative capacity that should be present at all stages of the innovation process, and a favorable institutional environment and, increasingly, of specific incentive policies. That is, there are internal and external factors to companies and other institutions involved in the process. Innovation systems were discovered to resolve the variations in the degree of competitiveness of different economies and, above all, in relation to the technological performance and the ability to innovate these economies face the growing importance of international markets for high-tech products. Thus, it was found that successful innovators are not successful just because of their personal qualities and actions but as a result of their interaction with research and innovation systems that inhabit the quality of such systems.

  12. Passive and Active Sensing Technologies for Structural Health Monitoring

    Science.gov (United States)

    Do, Richard

    A combination of passive and active sensing technologies is proposed as a structural health monitoring solution for several applications. Passive sensing is differentiated from active sensing in that with the former, no energy is intentionally imparted into the structure under test; sensors are deployed in a pure detection mode for collecting data mined for structural health monitoring purposes. In this thesis, passive sensing using embedded fiber Bragg grating optical strain gages was used to detect varying degrees of impact damage using two different classes of features drawn from traditional spectral analysis and auto-regressive time series modeling. The two feature classes were compared in detail through receiver operating curve performance analysis. The passive detection problem was then augmented with an active sensing system using ultrasonic guided waves (UGWs). This thesis considered two main challenges associated with UGW SHM including in-situ wave propagation property determination and thermal corruption of data. Regarding determination of wave propagation properties, of which dispersion characteristics are the most important, a new dispersion curve extraction method called sparse wavenumber analysis (SWA) was experimentally validated. Also, because UGWs are extremely sensitive to ambient temperature changes on the structure, it significantly affects the wave propagation properties by causing large errors in the residual error in the processing of the UGWs from an array. This thesis presented a novel method that compensates for uniform temperature change by considering the magnitude and phase of the signal separately and applying a scalable transformation.

  13. NASA'S information technology activities for the 90's

    Science.gov (United States)

    Holcomb, Lee; Erickson, Dan

    1991-01-01

    The Office of Aeronautics, Exploration and Technology (OAET) is completing an extensive assessment of its nearly five hundred million dollars of proposed space technology development work. The budget is divided into four segments which are as follows: (1) the base research and technology program; (2) the Civil Space Technology Initiative (CSTI); (3) the Exploration Technology Program (ETP); and (4) the High Performance Computing Initiative (HPCI). The programs are briefly discussed in the context of Astrotech 21.

  14. Practices of Technology Parks Supporting Innovative Activities: Evidence from Poland

    Directory of Open Access Journals (Sweden)

    Anna Wójcik-Karpacz

    2015-12-01

    Full Text Available The aim of the paper is to reveal the role of technology parks (TP in the creation of new businesses and the expansion of existing ones. This issue is part of a study aimed at finding an answer to the question of whether there is a link between the creation of new businesses and the development of existing ones, and regional environment factors. The analysis is carried out through the identification of activity of TPS functioning in Poland. The results of the study may also be the starting point for the diagnosis on behaviours of TPS as environmental factors in a specific region and an indication of the desired directions of its changes. The subject undertaken by us draws attention to the fact that the management of existing competences and creating new ones could allow TPS to compete outside of their current arenas of competition.

  15. Comparison of Exams for Active Learning Technologies vs. Traditional Lectures

    Science.gov (United States)

    Hornstra, Andrew; Djordjevic, Branislav; Dworzecka, Maria

    2017-01-01

    George Mason University has first semester (PHYS-160) and second semester (PHYS-260) physics course which consist of two sections. One is a traditional lecture style format (TRAD) and the other is a newer format which is a take on the ``flipped'' classroom. This newer style is referred to as Active Learning with Technologies (ALT). This course style has been in place for several years and has been studied before within George Mason University for final grade differences. These studies suggested that the ALT sections performed better, but grade weighting consistency, test time, and test content were not strictly controlled. The purpose of this study is to cross-examine the performance of students in these different class formats during Fall 2016 (PHYS-260) and Spring 2015 (PHYS-160) on very nearly identical exams over identical test times while controlling for almost every variable.

  16. A first thermodynamic interpretation of the technology transfer activities

    CERN Document Server

    Ripandelli, S

    2016-01-01

    In the last years new interdisciplinary approaches to economics and social science have been developed. A Thermodynamic approach to socio-economics has brought to a new interdisciplinary scientific field called econophysics. Why thermodynamic? Thermodynamic is a statistical theory for large atomic system under constraints of energy[1] and the economy can be considered a large system governed by complex rules. The present job proposes a new application, starting from econophysic, passing throughout the thermodynamic laws to interpret and to described the Technology Transfer (TT) activities. Using the definition of economy (i.e. economy[dictionary def.] = the process or system by which goods and services are produced, sold, and bought in a country or region) the TT can be considered an important sub-domain of the economy and a transversal new area of the scientific research. The TT is the process of transferring knowledge, that uses the results from the research to produce innovation and to ensure that scientif...

  17. H2/D2 exchange reaction on mono-disperse Pt clusters: enhanced activity from minute O2 concentrations

    DEFF Research Database (Denmark)

    Riedel, Jakob Nordheim; Rötzer, Marian David; Jørgensen, Mikkel;

    2016-01-01

    The H2/D2 exchange reaction was studied on mono-disperse Pt8 clusters in a μ-reactor. The chemical activity was studied at temperatures varying from room temperature to 180 °C using mass spectrometry. It was found that minute amounts of O2 in the gas stream increased the chemical activity...... significantly. XPS and ISS before and after reaction suggest little or no sintering during reaction. A reaction pathway is suggested based on DFT. H2 desorption is identified as the rate-limiting step and O2 is confirmed as the source of the increased activity. The binding energy of platinum atoms in a SiO2...... supported Pt8 cluster is found to be comparable to the interatomic binding energies of bulk platinum, underlining the stability of the model system....

  18. Neuroprotective profile of pyridothiazepines with blocking activity of the mitochondrial Na(+)/Ca(2+) exchanger.

    Science.gov (United States)

    Martínez-Sanz, Francisco J; Lajarín-Cuesta, Rocío; González-Lafuente, Laura; Moreno-Ortega, Ana J; Punzón, Eva; Cano-Abad, María F; de los Ríos, Cristóbal

    2016-02-15

    The mitochondrial Na(+)/Ca(2+) exchanger plays an important role in the control of cytosolic Ca(2+) cycling in excitable cells, essential for the regulation of a plethora of Ca(2+)-dependent physio-pathological events, such as apoptosis in the presence of a Ca(2+) overload. There are very few pharmacological tools available to study both physiological and pathological implications of the mitochondrial Na(+)/Ca(2+) exchanger, where the benzothiazepine CGP37157 is the best-known ligand, used since the 1980s. However, it is not an efficient blocker and lacks of selectivity, as also blocks several other cellular Ca(2+) transporters. Moreover, CGP37157 is a very lipophilic drug, showing very poor water solubility, what has hindered its therapeutic use. Attempting to improve its pharmacokinetic profile as well as its potency and selectivity, we herein describe the synthesis of new CGP37157 analogs, where the benzene-fused ring has been replaced by a pyridine. On top of a better water solubility and lower log P value, some of these new pyridothiazepine derivatives also presented a higher capacity to regulate the mitochondrial Ca(2+) clearance, while keeping the neuroprotective properties presented in the head compound CGP37157.

  19. Lactate Chemical Exchange Saturation Transfer (LATEST) Imaging in vivo A Biomarker for LDH Activity.

    Science.gov (United States)

    DeBrosse, Catherine; Nanga, Ravi Prakash Reddy; Bagga, Puneet; Nath, Kavindra; Haris, Mohammad; Marincola, Francesco; Schnall, Mitchell D; Hariharan, Hari; Reddy, Ravinder

    2016-01-22

    Non-invasive imaging of lactate is of enormous significance in cancer and metabolic disorders where glycolysis dominates. Here, for the first time, we describe a chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) method (LATEST), based on the exchange between lactate hydroxyl proton and bulk water protons to image lactate with high spatial resolution. We demonstrate the feasibility of imaging lactate with LATEST in lactate phantoms under physiological conditions, in a mouse model of lymphoma tumors, and in skeletal muscle of healthy human subjects pre- and post-exercise. The method is validated by measuring LATEST changes in lymphoma tumors pre- and post-infusion of pyruvate and correlating them with lactate determined from multiple quantum filtered proton magnetic resonance spectroscopy (SEL-MQC (1)H-MRS). Similarly, dynamic LATEST changes in exercising human skeletal muscle are correlated with lactate determined from SEL-MQC (1)H-MRS. The LATEST method does not involve injection of radioactive isotopes or labeled metabolites. It has over two orders of magnitude higher sensitivity compared to conventional (1)H-MRS. It is anticipated that this technique will have a wide range of applications including diagnosis and evaluation of therapeutic response of cancer, diabetes, cardiac, and musculoskeletal diseases. The advantages of LATEST over existing methods and its potential challenges are discussed.

  20. Basolateral Na+/HCO3– cotransport activity is regulated by the dissociable Na+/H+ exchanger regulatory factor

    Science.gov (United States)

    Bernardo, Angelito A.; Kear, Felicidad T.; Santos, Anna V.P.; Ma, Jianfei; Steplock, Debra; Robey, R. Brooks; Weinman, Edward J.

    1999-01-01

    In the renal proximal tubule, the activities of the basolateral Na+/HCO3– cotransporter (NBC) and the apical Na+/H+ exchanger (NHE3) uniformly vary in parallel, suggesting that they are coordinately regulated. PKA-mediated inhibition of NHE3 is mediated by a PDZ motif–containing protein, the Na+/H+ exchanger regulatory factor (NHE-RF). Given the common inhibition of these transporters after protein kinase A (PKA) activation, we sought to determine whether NHE-RF also plays a role in PKA-regulated NBC activity. Renal cortex immunoblot analysis using anti-peptide antibodies directed against rabbit NHE-RF demonstrated the presence of this regulatory factor in both brush-border membranes (BBMs) and basolateral membranes (BLMs). Using a reconstitution assay, we found that limited trypsin digestion of detergent solubilized rabbit renal BLM preparations resulted in NBC activity that was unaffected by PKA activation. Co-reconstitution of these trypsinized preparations with a recombinant protein corresponding to wild-type rabbit NHE-RF restored the inhibitory effect of PKA on NBC activity in a concentration-dependent manner. NBC activity was inhibited 60% by 10–8M NHE-RF; this effect was not observed in the absence of PKA. Reconstitution with heat-denatured NHE-RF also failed to attenuate NBC activity. To establish further a physiologic role for NHE-RF in NBC regulation, the renal epithelial cell line B-SC-1, which lacks detectable endogenous NHE-RF expression, was engineered to express stably an NHE-RF transgene. NHE-RF–expressing B-SC-1 cells (B-SC-RF) exhibited markedly lower basal levels of NBC activity than did wild-type controls. Inhibition of NBC activity in B-SC-RF cells was enhanced after 10 μM of forskolin treatment, consistent with a postulated role for NHE-RF in mediating the inhibition of NBC activity by PKA. These findings not only suggest NHE-RF involvement in PKA-regulated NBC activity, but also provide a unique molecular mechanism whereby

  1. Development of Technology and Equipment of the Automated Laser Welding for Manufacturing Heat Exchanger Details of Marine Engines

    Directory of Open Access Journals (Sweden)

    Shelyagin, V.D.

    2014-09-01

    Full Text Available Based on the developed automated laser welding technology for flat tubes of copper-nickel alloys laser welding complex technological equipment, which can be applied on the enterprises of machine building, aerospace, shipbuilding and automobile industries, was designed and created. To control the integrity of welded flat tubes a technique, which consists in testing sample pressure and finding defective sections by laser interferometry in the automated mode, was developed. Specialized welding head was designed and manufactured for the industrial use of the developed laser welding technology.

  2. Engineer exchanging project on coal mine technology field in fiscal 1999. International information exchanging project (advance survey on North America); 1999 nendo gijutsusha koryu jigyo (tanko gijutsu bun'ya) kokusai koryu jigyo. Jizen chosa (Hokubei)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    This project has been performed with an intention of making visiting surveys and information collection at coal related organizations in overseas coal producing countries on production technology levels and trends. The project is intended to serve for improvement in the contents of and smooth execution of the engineer exchange project in the 'coal mine technology field. It was carried out by the site surveys. The surveys revealed that the situation of the American coal industry is expected of stable increase in the demand and supply in the future, but the coal price is on the falling trend, and therefore, the industry is compelled to further increase the intensity and enhance the productivity. The industry is strongly influenced by the amended air pollution prevention act and nature destruction problems, hence further coal mine curtailment is estimated. Under such a background, it was found that the long-wall mining process progressing toward larger scale and higher productivity, and the high-wall mining process that provides higher productivity at lower cost and has less impact on the environmental problems can continue development in mountainous areas, particularly in the Appalachian area. The high-wall mining process mines coal at exposed facings on the side of a mountain by using a continuous miner, and transports the coal using machines. (NEDO)

  3. Using Scientific Detective Videos to Support the Design of Technology Learning Activities

    Science.gov (United States)

    Yu, Kuang-Chao; Fan, Szu-Chun; Tsai, Fu-Hsing; Chu, Yih-hsien

    2013-01-01

    This article examines the effect of scientific detective video as a vehicle to support the design of technology activities by technology teachers. Ten graduate students, including current and future technology teachers, participated in a required technology graduate course that used scientific detective videos as a pedagogical tool to motivate…

  4. Using Scientific Detective Videos to Support the Design of Technology Learning Activities

    Science.gov (United States)

    Yu, Kuang-Chao; Fan, Szu-Chun; Tsai, Fu-Hsing; Chu, Yih-hsien

    2013-01-01

    This article examines the effect of scientific detective video as a vehicle to support the design of technology activities by technology teachers. Ten graduate students, including current and future technology teachers, participated in a required technology graduate course that used scientific detective videos as a pedagogical tool to motivate…

  5. Fiscal 2000 survey of geological structures overseas. Exchange of engineers with China (Coal mining technology); 2000 nendo kaigai chishitsu kozo nado chosa hokokusho. Gijutsusha koryu jigyo (tanko gijutsu bun'ya) kenshu Chugoku

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    A coal mining engineer exchange project was implemented by Japan and China for improving on coal mining engineers' production and management technologies in the Asia-Pacific region. Six engineers were dispatched to the jurisdiction of Kailuan Co., Ltd., Tangshan City, who stayed there in the period November 12 through December 2, 2000. The six engineers gave lectures and training on the coal situation in the world, coal mining technology, degassing technology, production control technology, safety management technology, management technology, and the like. Ten trainees were received, who were given lectures and training at Taiheiyo Coal Mining Corporation, Kushiro City, in the period November 12 through December 2, 2000. Coal mining technologies that were taught involved drift excavation, rock-bed excavation, rock bolting, and transportation. Production control technologies that were taught involved production control, equipment management, technology development, quality control, risk control, and management technologies. (NEDO)

  6. NASA/University JOint VEnture (JOVE) Program. VIXEN(tm): Object-Oriented, Technology-Adaptive, Virtual Information Exchange Environment

    Science.gov (United States)

    Anyiwo, Joshua C.

    2000-01-01

    Vixen is a collection of enabling technologies for uninhibited distributed object computing. In the Spring of 1995 when Vixen was proposed, it was an innovative idea very much ahead of its time. But today the technologies proposed in Vixen have become standard technologies for Enterprise Computing. Sun Microsystems J2EE/EJB specifications, among others, are independently proposed technologies of the Vixen type. I have brought Vixen completely under the J2EE standard in order to maximize interoperability and compatibility with other computing industry efforts. Vixen and the Enterprise JavaBean (EJB) Server technologies are now practically identical; OIL, another Vixen technology, and the Java Messaging System (JMS) are practically identical; and so on. There is no longer anything novel or patentable in the Vixen work performed under this grant. The above discussion, notwithstanding, my independent development of Vixen has significantly helped me, my university, my students and the local community. The undergraduate students who worked with me in developing Vixen have enhanced their expertise in what has become the cutting edge technology of their industry and are therefore well positioned for lucrative employment opportunities in the industry. My academic department has gained a new course: "Multi-media System Development", which provides a highly desirable expertise to our students for employment in any enterprise today. The many Outreach Programs that I conducted during this grant period have exposed local Middle School students to the contributions that NASA is making in our society as well as awakened desires in many such students for careers in Science and Technology. I have applied Vixen to the development of two software packages: (a) JAS: Joshua Application Server - which allows a user to configure an EJB Server to serve a J2EE compliant application over the world wide web; (b) PCM: Professor Course Manager: a J2EE compliant application for configuring a

  7. Agricultural Science and Technology Teachers' Perceptions of iPod and Mp3 Technology Integration into Curricular and Cocurricular Activities

    Science.gov (United States)

    Murphrey, Theresa Pesl; Miller, Kimberly A.; Roberts, T. Grady

    2009-01-01

    The purpose of this study was to describe agricultural science and technology teachers' reaction to iPod and mp3 technology use and potential use in both curricular and cocurricular activities. A total of 112 unique respondents provided written responses to open-ended questions. Study findings reveal that agricultural science and technology…

  8. Teachers as co-designers of technology-rich learning activities for emergent literacy

    NARCIS (Netherlands)

    Cviko, Amina; McKenney, Susan; Voogt, Joke

    2016-01-01

    Although kindergarten teachers often struggle with implementing technology, they are rarely involved in co-designing technology-rich learning activities. This study involved teachers in the co-design of technology-rich learning activities and sought to explore implementation and pupil learning outc

  9. Teachers as co-designers of technology-rich learning activities for early literacy

    NARCIS (Netherlands)

    Cviko, Amina; McKenney, Susan; Voogt, Joke

    2015-01-01

    Although kindergarten teachers often struggle with implementing technology, they are rarely involved in co-designing technology-rich learning activities. This study involved teachers in the co-design of technology-rich learning activities and sought to explore implementation and pupil learning outco

  10. Teachers as Co-Designers of Technology-Rich Learning Activities for Early Literacy

    Science.gov (United States)

    Cviko, Amina; McKenney, Susan; Voogt, Joke

    2015-01-01

    Although kindergarten teachers often struggle with implementing technology, they are rarely involved in co-designing technology-rich learning activities. This study involved teachers in the co-design of technology-rich learning activities and sought to explore implementation and pupil learning outcomes. A case-study method was used to investigate:…

  11. Teachers as co-designers of technology-rich learning activities for early literacy

    NARCIS (Netherlands)

    Cviko, Amina; McKenney, Susan; Voogt, Joke

    2015-01-01

    Although kindergarten teachers often struggle with implementing technology, they are rarely involved in co-designing technology-rich learning activities. This study involved teachers in the co-design of technology-rich learning activities and sought to explore implementation and pupil learning outco

  12. Teachers as co-designers of technology-rich learning activities for emergent literacy

    NARCIS (Netherlands)

    Cviko, Amina; McKenney, Susan; Voogt, Joke

    2016-01-01

    Although kindergarten teachers often struggle with implementing technology, they are rarely involved in co-designing technology-rich learning activities. This study involved teachers in the co-design of technology-rich learning activities and sought to explore implementation and pupil learning outc

  13. Teachers as co-designers of technology-rich learning activities for early literacy

    NARCIS (Netherlands)

    Cviko, Amina; McKenney, Susan; Voogt, Joke

    2015-01-01

    Although kindergarten teachers often struggle with implementing technology, they are rarely involved in co-designing technology-rich learning activities. This study involved teachers in the co-design of technology-rich learning activities and sought to explore implementation and pupil learning

  14. Teachers as co-designers of technology-rich learning activities for emergent literacy

    NARCIS (Netherlands)

    Cviko, Amina; McKenney, Susan; Voogt, Joke

    2016-01-01

    Although kindergarten teachers often struggle with implementing technology, they are rarely involved in co-designing technology-rich learning activities. This study involved teachers in the co-design of technology-rich learning activities and sought to explore implementation and pupil learning

  15. Sustained Na+/H+ exchanger activation promotes gliotransmitter release from reactive hippocampal astrocytes following oxygen-glucose deprivation.

    Directory of Open Access Journals (Sweden)

    Pelin Cengiz

    Full Text Available Hypoxia ischemia (HI-related brain injury is the major cause of long-term morbidity in neonates. One characteristic hallmark of neonatal HI is the development of reactive astrogliosis in the hippocampus. However, the impact of reactive astrogliosis in hippocampal damage after neonatal HI is not fully understood. In the current study, we investigated the role of Na(+/H(+ exchanger isoform 1 (NHE1 protein in mouse reactive hippocampal astrocyte function in an in vitro ischemia model (oxygen/glucose deprivation and reoxygenation, OGD/REOX. 2 h OGD significantly increased NHE1 protein expression and NHE1-mediated H(+ efflux in hippocampal astrocytes. NHE1 activity remained stimulated during 1-5 h REOX and returned to the basal level at 24 h REOX. NHE1 activation in hippocampal astrocytes resulted in intracellular Na(+ and Ca(2+ overload. The latter was mediated by reversal of Na(+/Ca(2+ exchange. Hippocampal astrocytes also exhibited a robust release of gliotransmitters (glutamate and pro-inflammatory cytokines IL-6 and TNFα during 1-24 h REOX. Interestingly, inhibition of NHE1 activity with its potent inhibitor HOE 642 not only reduced Na(+ overload but also gliotransmitter release from hippocampal astrocytes. The noncompetitive excitatory amino acid transporter inhibitor TBOA showed a similar effect on blocking the glutamate release. Taken together, we concluded that NHE1 plays an essential role in maintaining H(+ homeostasis in hippocampal astrocytes. Over-stimulation of NHE1 activity following in vitro ischemia disrupts Na(+ and Ca(2+ homeostasis, which reduces Na(+-dependent glutamate uptake and promotes release of glutamate and cytokines from reactive astrocytes. Therefore, blocking sustained NHE1 activation in reactive astrocytes may provide neuroprotection following HI.

  16. Information Technology and Aesthetics: Passive and Active Dimensions

    Directory of Open Access Journals (Sweden)

    John D Haynes

    2007-09-01

    Full Text Available This paper is concerned with examining and recognizing aesthetics in an Information System (an organization incorporating both humans and information technology. Aesthetics emerge from the wholeness of things, not from specific parts or components. As such, aesthetics may naturally be considered in “systems”, and we propose that an effective manner of thinking of aesthetics is to think in terms of “themes”. Humans have an extraordinary capacity to capture events thematically. In other words, human beings have a natural sense of aesthetics. To examine aesthetics in an information systems context, we argue that one must consider not only aesthetics that may be perceived by the senses (a passive dimension, but also aesthetics that may be conceived in the mind (an active dimension. This paper draws the conclusion that the benefits of aesthetics in relation to the study of Information Systems, has characteristics similar to the nature and importance of ethics in IS. Also, the study of aesthetics in IS has greater implications than simply recognizing and appreciating beauty and art. The very human capacity for recognizing and appreciating beauty and art is also the same capacity for effective creativity and happiness: the active aesthetic dimension. It follows that if an information system encouraged and provided the enabling circumstances for the human capacity of thematic recognition (as found in the human appreciation of art and beauty it thereby also provides the ground and the necessary thematically recognizable stimulus for effective creative and visionary organizational management.

  17. Ric-8A, a G protein chaperone with nucleotide exchange activity induces long-range secondary structure changes in Gα.

    Science.gov (United States)

    Kant, Ravi; Zeng, Baisen; Thomas, Celestine J; Bothner, Brian; Sprang, Stephen R

    2016-12-23

    Cytosolic Ric-8A has guanine nucleotide exchange factor (GEF) activity and is a chaperone for several classes of heterotrimeric G protein α subunits in vertebrates. Using Hydrogen-Deuterium Exchange-Mass Spectrometry (HDX-MS) we show that Ric-8A disrupts the secondary structure of the Gα Ras-like domain that girds the guanine nucleotide-binding site, and destabilizes the interface between the Gαi1 Ras and helical domains, allowing domain separation and nucleotide release. These changes are largely reversed upon binding GTP and dissociation of Ric-8A. HDX-MS identifies a potential Gα interaction site in Ric-8A. Alanine scanning reveals residues crucial for GEF activity within that sequence. HDX confirms that, like G protein-coupled receptors (GPCRs), Ric-8A binds the C-terminus of Gα. In contrast to GPCRs, Ric-8A interacts with Switches I and II of Gα and possibly at the Gα domain interface. These extensive interactions provide both allosteric and direct catalysis of GDP unbinding and release and GTP binding.

  18. 基于VB技术的管壳式换热器传热计算系统开发%Development of heat transfer calculation system of tube shell heat exchanger based on VB technology

    Institute of Scientific and Technical Information of China (English)

    冯婕; 朱小军

    2016-01-01

    VB technology development shell and tube heat exchanger computing systems,is an innovative theory and practice,to improve computational efficiency of heat transfer heat exchanger has a great significance.This paper analyzes the Heat Exchanger computing systems,as well as technology in the VB Shell and Tube Heat Exchanger computing systems development.%运用VB技术开发管壳式换热器传热计算系统,是一种理论上和实践上的创新,对提高我国的换热器传热计算效率具有重要的意义。本文主要分析了换热器的传热计算系统,以及VB技术在管壳式换热器传热计算系统开发中的应用。

  19. Fiscal 1997 technological survey report. Engineer exchange project - coal mine technological field (Advanced coal producing country survey - U.S.A. survey); 1997 nendo gijutsusha koryu jigyo (tanko gijutsu bun'ya) senshin santankoku chosa. Beikoku chosa

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-03-01

    While the introduction and adaptation of the Longwall excavation technology were carried forward for coal producing countries in the Pacific region, U.S.A. information was collected by making tours of coal mines in the West and Washington/Colorado/Utah States, with the intention of ascertaining technological trend so as to carry out efficient technological transfer, and for the purpose of replenishing the contents and contributing to the smooth implementation of the engineer exchange project in 'coal mine technological field'. The coal reserves are 400 billion tons, with 840 million tons produced and with 80 million tons exported; not less than 56% of the U.S. domestic electricity rests on coal. Production by open-pit mining is the majority while the output by underground mining is 38%; the Longwall method has increased as a digging method, taking 18% of all digging output. The productivity is 4.24 ton/person per day and ranks as the world highest. The coal mining technological trend in the U.S. can be summarized as follows. The coal mining output in the West is increasing, with the number of mines decreasing, so that the output per mine is increasing. With the output ratio by open-pit mining increasing, the digging method in the mine is being changed to the Longwall. (NEDO)

  20. 75 FR 33631 - Science and Technology (S&T) Directorate; Agency Information Collection Activities: Submission...

    Science.gov (United States)

    2010-06-14

    ... SECURITY Science and Technology (S&T) Directorate; Agency Information Collection Activities: Submission for Review; Information Collection Request for the Department of Homeland Security (DHS) Science and... Security's (DHS's) Science and Technology (S&T) Directorate to provide information, resources...

  1. Na+/H+ exchanger isoform 1 induced cardiomyocyte hypertrophy involves activation of p90 ribosomal s6 kinase.

    Science.gov (United States)

    Jaballah, Maiy; Mohamed, Iman A; Alemrayat, Bayan; Al-Sulaiti, Fatima; Mlih, Mohamed; Mraiche, Fatima

    2015-01-01

    Studies using pharmacological and genetic approaches have shown that increased activity/expression of the Na+/H+ exchanger isoform 1 (NHE1) play a critical role in the pathogenesis of cardiac hypertrophy. Despite the importance of NHE1 in cardiac hypertrophy, severe cerebrovascular side effects were associated with the use of NHE1 inhibitors when administered to patients with myocardial infarctions. p90 ribosomal S6 Kinase (RSK), a downstream regulator of the mitogen-activated protein kinase pathway, has also been implicated in cardiac hypertrophy. We hypothesized that RSK plays a role in the NHE1 induced cardiomyocyte hypertrophic response. Infection of H9c2 cardiomyoblasts with the active form of the NHE1 adenovirus induced hypertrophy and was associated with an increase in the phosphorylation of RSK (Phypertrophy such as cell area, protein content and atrial natriuretic mRNA expression were significantly reduced in H9c2 cardiomyoblasts infected with active NHE1 in the presence of dominant negative RSK (DN-RSK) (Phypertrophy is accounted for by increased activation and phosphorylation of RSK, which subsequently increased the phosphorylation of GATA4; eventually activating fetal gene transcriptional machinery.

  2. Educational Technology as a Subversive Activity: Questioning Assumptions Related to Teaching and Leading with Technology

    Science.gov (United States)

    Kruger-Ross, Matthew J.; Holcomb, Lori B.

    2012-01-01

    The use of educational technologies is grounded in the assumptions of teachers, learners, and administrators. Assumptions are choices that structure our understandings and help us make meaning. Current advances in Web 2.0 and social media technologies challenge our assumptions about teaching and learning. The intersection of technology and…

  3. XML在Domino环境中异构数据交换技术应用%Application of XML Technology on Heterogeneous Data Exchange in Domino Environment

    Institute of Scientific and Technical Information of China (English)

    张正做; 周霖

    2013-01-01

      To effectively solve the problem of heterogeneous data integration between the drug testing management system and other systems, introduces the principle of data change using XML in Lotus Domino platform, and particularly discusses the technology of drug information exchange under the environment of Lotus Domino platform based on the XML technology. Obtains a conclusion that the corresponding application system will be flexibility and portability if uses the technology of XML for heterogeneous data change.%  为了解决本院药品检验系统中内部数据与外部数据集成问题,概括介绍利用XML在Lotus Domino 环境中进行数据交换的原理,并详细讨论在Lotus Domino环境中利用XML 实现检品信息交换的技术,得出结论在Lotus Domino环境中利用XML进行异构数据交换为应用系统带来更大的灵活性。

  4. TASTE MASKING TECHNOLOGIES: A NOVEL APPROACH FOR THE IMPROVEMENT OF ORGANOLEPTIC PROPERTY OF PHARMACEUTICAL ACTIVE SUBSTANCE

    Directory of Open Access Journals (Sweden)

    Sharma Deepak

    2012-04-01

    Full Text Available Acceptability of any dosage form are mainly depends over its taste i.e. mouth feel. Drug molecule interacts with taste receptor on the tongue to give bitter, sweet or salty taste sensation, when they dissolve in saliva. This sensation of the taste is the result of signal transduction from the receptor organs for taste, commonly known as taste buds. In market, there are numbers of pharmaceutical preparations available in which actives are bitter in taste. The improved palatability in these products has prompted the development of numerous formulations, which improved performance and acceptability. The bitterness of preparation also leads to patient incompliance. So masking of bitterness becomes essential. To overcome this problem, many techniques have been developed to mask the bitter taste of drugs. These techniques are not only mask the bitter taste of drug but also enhance the bioavailability and performance of drug dosage form. It includes adding sugars, flavors, sweeteners, use of lipoproteins, numbing taste buds, granulation, use of adsorbates ,coating drug, microencapsulation, multiple emulsion, viscosity modifier, vesicles and liposomes, prodrug and salt formation, inclusion and molecular complexes, solid dispersion and Ion Exchange Resins (IERs which have been tried by the formulators to mask the unpleasant taste of the bitter drugs. The present review article highlights different technologies of taste masking with respect to dosage form and novel methods of evaluation of taste masking effect.

  5. SPINES Pilot Programme for the International Exchange of Information on the Application of Science and Technology to Development.

    Science.gov (United States)

    United Nations Educational, Scientific, and Cultural Organization, Paris (France).

    This report describes the pilot program for SPINES, a computerized system for collecting, selecting, analysing, and disseminating documents and factual data that have a direct bearing on policy-making, arrangement, transfer, and assessment in science and technology. This data is needed in developing policies for the advancement of science and…

  6. Engineering and Technology Challenges for Active Debris Removal

    Science.gov (United States)

    Liou, Jer-Chyi

    2011-01-01

    After more than fifty years of space activities, the near-Earth environment is polluted with man-made orbital debris. The collision between Cosmos 2251 and the operational Iridium 33 in 2009 signaled a potential collision cascade effect, also known as the "Kessler Syndrome", in the environment. Various modelling studies have suggested that the commonly-adopted mitigation measures will not be sufficient to stabilize the future debris population. Active debris removal must be considered to remediate the environment. This paper summarizes the key issues associated with debris removal and describes the technology and engineering challenges to move forward. Fifty-four years after the launch of Sputnik 1, satellites have become an integral part of human society. Unfortunately, the ongoing space activities have left behind an undesirable byproduct orbital debris. This environment problem is threatening the current and future space activities. On average, two Shuttle window panels are replaced after every mission due to damage by micrometeoroid or orbital debris impacts. More than 100 collision avoidance maneuvers were conducted by satellite operators in 2010 to reduce the impact risks of their satellites with respect to objects in the U.S. Space Surveillance Network (SSN) catalog. Of the four known accident collisions between objects in the SSN catalog, the last one, collision between Cosmos 2251 and the operational Iridium 33 in 2009, was the most significant. It was the first ever accidental catastrophic destruction of an operational satellite by another satellite. It also signaled the potential collision cascade effect in the environment, commonly known as the "Kessler Syndrome," predicted by Kessler and Cour-Palais in 1978 [1]. Figure 1 shows the historical increase of objects in the SSN catalog. The majority of the catalog objects are 10 cm and larger. As of April 2011, the total objects tracked by the SSN sensors were more than 22,000. However, approximately 6000 of

  7. United States-Chile binational exchange for volcanic risk reduction, 2015—Activities and benefits

    Science.gov (United States)

    Pierson, Thomas C.; Mangan, Margaret T.; Lara Pulgar, Luis E.; Ramos Amigo, Álvaro

    2017-07-25

    In 2015, representatives from the United States and Chile exchanged visits to discuss and share their expertise and experiences dealing with volcano hazards. Communities in both countries are at risk from various volcano hazards. Risks to lives and property posed by these hazards are a function not only of the type and size of future eruptions but also of distances from volcanoes, structural integrity of volcanic edifices, landscape changes imposed by recent past eruptions, exposure of people and resources to harm, and any mitigative measures taken (or not taken) to reduce risk. Thus, effective risk-reduction efforts require the knowledge and consideration of many factors, and firsthand experience with past volcano crises provides a tremendous advantage for this work. However, most scientists monitoring volcanoes and most officials delegated with the responsibility for emergency response and management in volcanic areas have little or no firsthand experience with eruptions or volcano hazards. The reality is that eruptions are infrequent in most regions, and individual volcanoes may have dormant periods lasting hundreds to thousands of years. Knowledge may be lacking about how to best plan for and manage future volcanic crises, and much can be learned from the sharing of insights and experiences among counterpart specialists who have had direct, recent, or different experiences in dealing with restless volcanoes and threatened populations. The sharing of information and best practices can help all volcano scientists and officials to better prepare for future eruptions or noneruptive volcano hazards, such as large volcanic mudflows (lahars), which could affect their communities.

  8. Survey report of FY 1997 on the global environmental industry technology development promotion project. International research exchange project; 1997 nendo chosa hokokusho. Chikyu kankyo sangyo gijutsu kaihatsu suishin jigyo (kokusai kenkyu koryu jigyo)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-03-01

    Exchange of personnel among foreign research organizations is significant for promoting research and development to create new research fields and to build new technological systems for the purpose of solving global environmental problems. For this purpose, researchers were sent/invited to/from international conferences and international symposiums related to global environmental technology and exchange of personnel with major foreign research organizations and universities was conducted under the cooperation of RITE and RITE-related researchers and related academic societies. Based on short-term invitation and sending of researchers as well as the feasibility study of researcher exchange, researchers were sent/invited on long- and mid-terms. As a result, exchange of personnel engaged in the latest research in Japan and overseas could be promoted. It was found that various researches are being conducted abroad in basic areas of global environmental technology. Since they are closely related to the research and development of industrial technology contributing to global environmental preservation promoted by RITE, it is important to establish a more efficient exchange system of researchers in the future. 91 refs., 38 figs., 14 tabs.

  9. How to change GEBCO outreach activities with Information technologies?

    Science.gov (United States)

    Chang, E.; Park, K.

    2014-12-01

    Since 1995, when National Geographic Information Project began, we have great advance in mapping itself and information service on the earth surface in Korea whether paper maps or online service map. By reviewing geological and mine-related information service in current and comparisons of demands, GEBCO outreach master plan has been prepared. Information service cannot be separated from data production and on dissemination policies. We suggest the potential impact of the changes in information technologies such as mobile service and data fusion, and big data on GEBCO maps based. Less cost and high performance in data service will stimulate more information service; therefore it is necessary to have more customer-oriented manipulation on the data. By inquiring questionnaire, we can draw the potential needs on GEBCO products in various aspects: such as education, accessibility. The gap between experts and non-experts will decrease by digital service from the private and public organizations such as international academic societies since research funds and policies tend to pursue "openness" and "interoperability" among the domains. Some background why and how to prepare outreach activities in GEBCO will be shown.

  10. Regulation of Ras exchange factors and cellular localization of Ras activation by lipid messengers in T cells

    Directory of Open Access Journals (Sweden)

    Jesse E. Jun

    2013-09-01

    Full Text Available The Ras-MAPK signaling pathway is highly conserved throughout evolution and is activated downstream of a wide range of receptor stimuli. Ras guanine nucleotide exchange factors (RasGEFs catalyze GTP loading of Ras and play a pivotal role in regulating receptor-ligand induced Ras activity. In T cells, three families of functionally important RasGEFs are expressed: RasGRF, RasGRP, and SOS-family GEFs.Early on it was recognized that Ras activation is critical for T cell development and that the RasGEFs play an important role herein. More recent work has revealed that nuances in Ras activation appear to significantly impact T cell development and selection. These nuances include distinct biochemical patterns of analog versus digital Ras activation, differences in cellular localization of Ras activation, and intricate interplays between the RasGEFs during distinct T cell developmental stages as revealed by various new mouse models. In many instances, the exact nature of these nuances in Ras activation or how these may result from fine-tuning of the RasGEFs is not understood.One large group of biomolecules critically involved in the control of Ras-GEFs´functions are lipid second messengers. Multiple, yet distinct lipid products are generated following T cell receptor (TCR stimulation and bind to different domains in the RasGRP and SOS RasGEFs to facilitate the activation of the membrane-anchored Ras GTPases. In this review we highlight how different lipid-based elements are generated by various enzymes downstream of the TCR and other receptors and how these dynamic and interrelated lipid products may fine-tune Ras activation by RasGEFs in developing T cells.

  11. IEA/ETDE - Energy Technology Data Exchange - Providing a worldwide R and D Knowledge Base; IEA/ETDEWEB - World Energy Base

    Energy Technology Data Exchange (ETDEWEB)

    Aarniala, M. [Tekes, Helsinki (Finland); Tommila, P. [Ministry of Trade and Industry, Helsinki (Finland); Tolonen, E. [Helsinki Univ. of Technology, Espoo (Finland)

    2006-12-20

    ETDE is a multilateral information exchange program with sixteen countries participating: Brazil, Canada, Denmark, Finland, France, Germany, Korea ,Rep.of, Mexico, The Netherlands, Norway, Portugal, Spain, Sweden, Switzerland, United Kingdom and United States. ETDE is considered an Implementing Agreement of the International Energy Agency (IEA). Information in the ETDE's database is available on the Web in the ETDEWEB orld Energy Base. The database contains energy R and D results, the environmental impact of energy production and use including climate, energy policy, coal, hydrocarbon and renewable energy technologies, energy efficiency information and much more. With ETDEWEB-World Energy Base, it is easier than ever to check on recent developments in various research areas (including some basic research), to see how countries deal with energy elated environmental and climate change issues and eventually find approaches to energy use, including policy and economic factors, alternative and renewable energy sources and conservation aspects. (orig.)

  12. IEA/ETDE- Energy Technology Data Exchange Providing a worldwide R and D Knowledge Base; IEA/ETDEWEB - World Energy Base

    Energy Technology Data Exchange (ETDEWEB)

    Aarniala, M. [Tekes, Helsinki (Finland); Tommila, P. [Ministry of Trade and Industry, Helsinki (Finland); Tolonen, E. [Helsinki Univ. of Technology, Espoo (Finland)

    2007-07-01

    ETDE is a multilateral information exchange program with sixteen countries participating: Brazil, Canada, Denmark, Finland, France, Germany, Korea, Rep.of, Mexico, The Netherlands, Norway, Portugal, Spain, Sweden, Switzerland, United Kingdom and United States. ETDE is considered an Implementing Agreement of the International Energy Agency (IEA). Information in the ETDE's database is available on the Web in the ETDEWEB-World Energy Base. The database contains energy R and D results, the environmental impact of energy production and use including climate, energy policy, coal, hydrocarbon and renewable energy technologies, energy efficiency information and much more. With ETDEWEB-World Energy Base, it is easier than ever to check on recent developments in various research areas (including some basic research), to see how countries deal with energy-related environmental and climate change issues and eventually find approaches to energy use, including policy and economic factors, alternative and renewable energy sources and conservation aspects. (orig.)

  13. Species active in the selective catalytic reduction of no with iso-butane on iron-exchanged ZSM-5 zeolites

    Directory of Open Access Journals (Sweden)

    M. S. Batista

    2005-09-01

    Full Text Available Fe-ZSM-5 catalysts were prepared by ion exchange in aqueous medium or in the solid state and tested in the catalytic reduction of NO with iso-butane. X-ray powder diffraction (XRD, atomic absorption spectroscopy (AAS, electron paramagnetic resonance spectroscopy (EPR, X-ray absorption spectroscopy (XANES, EXAFS, temperature-programmed reduction by H2 (H2-TPR and Mössbauer spectroscopy (MÖS-S were used for sample characterisation. Irrespective of the method used in catalyst preparation, EPR, XANES and MÖS-S showed Fe atoms in the oxidation state of 3+. MÖS-S and H2-TPR data on Fe-ZSM-5 prepared by ion exchange in the solid state allowed quantification of a lower hematite (Fe2O3 concentration and a higher proportion of Fe cations than samples prepared in an aqueous medium. In all the catalysts studied these Fe cations were the active sites in the reduction of NO to N2 and in the oxidation of iso-butane. It is further suggested that coordination of Fe species is another important aspect to be considered in their behaviour.

  14. South Africa calls Italy: effective exchange activity through costless (Skype like) connections in the framework of the EU UNAWE project

    Science.gov (United States)

    Zanazzi, A.; Albanese, L.; Naidoo, T.

    2014-10-01

    In summer 2012 the Italian EU-UNAWE team joined with the South African team in Cape Town, working with the township schools organizing activities at school and also a teachers' training event at the SAAO Observatory. In order to involve in the exchange not only the project's experts but also to the teachers and the children, we organized Skype connections between the Cape town teachers participating in the project and the teachers in Sicily (South Italy) that also participated in one of the Italian training sessions and later between the children of the Italian school and those in Zanemfundo School (Cape Town). Thanks to this chance of seeing each other and talking directly, children have - with huge interest and participation - shared and learned methods, experiences, curiosities. They shared their prepared actual science researches, in order to understand why an equal gnomon cast different shadows at the same time in the two countries. The teachers confronted on curricula, didactic methodologies such as working with a background story during the whole school year, interdisciplinary uses of astronomy, languages etc. The EU-UNAWE project and International or Regional conferences such as LARIM are perfect chances to create exchanges between countries all around the World, and this simple communication model between children and teachers appears like an enormous resource yet to be fully exploited.

  15. Metaldehyde removal from aqueous solution by adsorption and ion exchange mechanisms onto activated carbon and polymeric sorbents.

    Science.gov (United States)

    Tao, Bing; Fletcher, Ashleigh J

    2013-01-15

    Metaldehyde removal from aqueous solution was evaluated using granular activated carbon (GAC), a non-functionalised hyper-cross-linked polymer Macronet (MN200) and an ion-exchange resin (S957) with sulfonic and phosphonic functional groups. Equilibrium experimental data were successfully described by Freundlich isotherm models. The maximum adsorption capacity of S957 (7.5 g metaldehyde/g S957) exceeded those of MN200 and GAC. Thermodynamic studies showed that sorption of metaldehyde onto all sorbents is endothermic and processes are controlled by entropic rather than enthalpic changes. Kinetic experiments demonstrated that experimental data for MN200 and GAC obey pseudo-second order models with rates limited by particle diffusion. Comparatively, S957 was shown to obey a pseudo-first order model with a rate-limiting step of metaldehyde diffusion through the solid/liquid interface. Results obtained suggest that metaldehyde adsorption onto MN200 and GAC are driven by hydrophobic interactions and hydrogen bonding, as leaching tendencies were high since no degradation of metaldehyde occurred. Conversely, adsorption of metaldehyde onto S957 occurs via ion-exchange processes, where sulfonic and phosphonic functionalities degrade adsorbed metaldehyde molecules and failure to detect metaldehyde in leaching studies for S957 supports this theory. Consequently, the high adsorption capacity and absence of leaching indicate S957 is promising for metaldehyde removal from source water. Copyright © 2012 Elsevier B.V. All rights reserved.

  16. Contribution of reverse Na+-Ca2+ exchange to spontaneous activity in interstitial cells of Cajal in the rabbit urethra.

    Science.gov (United States)

    Bradley, E; Hollywood, M A; Johnston, L; Large, R J; Matsuda, T; Baba, A; McHale, N G; Thornbury, K D; Sergeant, Gerard P

    2006-08-01

    Interstitial cells of Cajal (ICC) isolated from the rabbit urethra exhibit regular Ca2+ oscillations that are associated with spontaneous transient inward currents (STICs) recorded under voltage clamp. Their frequency is known to be very sensitive to external Ca2+ concentration but the mechanism of this has yet to be elucidated. In the present study experiments were performed to assess the role of Na+-Ca2+ exchange (NCX) in this process. Membrane currents were recorded using the patch clamp technique and measurements of intracellular Ca2+ were made using fast confocal microscopy. When reverse mode NCX was enhanced by decreasing the external Na+ concentration [Na+]o from 130 to 13 mM, the frequency of global Ca2+ oscillations and STICs increased. Conversely, inhibition of reverse mode NCX by KB-R7943 and SEA0400 decreased the frequency of Ca2+ oscillations and STICs. Application of caffeine (10 mM) and noradrenaline (10 microM) induced transient Ca2+-activated chloride currents (I(ClCa)) at -60 mV due to release of Ca2+ from ryanodine- and inositol trisphosphate (IP3)-sensitive Ca2+ stores, respectively, but these responses were not blocked by KB-R7943 or SEA0400 suggesting that neither drug blocked Ca2+-activated chloride channels or Ca2+ release from stores. Intact strips of rabbit urethra smooth muscle develop spontaneous myogenic tone. This tone was relaxed by application of SEA0400 in a concentration-dependent fashion. Finally, single cell RT-PCR experiments revealed that isolated ICC from the rabbit urethra only express the type 3 isoform of the Na+-Ca2+ exchanger (NCX3). These results suggest that frequency of spontaneous activity in urethral ICC can be modulated by Ca2+ entry via reverse NCX.

  17. The Teacher as Re-Designer of Technology Integrated Activities for an Early Literacy Curriculum

    Science.gov (United States)

    Cviko, Amina; McKenney, Susan; Voogt, Joke

    2013-01-01

    Though popular among children outside of school, Dutch teachers often struggle to offer technology integrated activities in the kindergarten classroom. Because involving teachers in development of technology integrated activities can support their implementation, this study examines teachers in the role of re-designing such activities. Two case…

  18. Advanced Power Technology Development Activities for Small Satellite Applications

    Science.gov (United States)

    Piszczor, Michael F.; Landis, Geoffrey A.; Miller, Thomas B.; Taylor, Linda M.; Hernandez-Lugo, Dionne; Raffaelle, Ryne; Landi, Brian; Hubbard, Seth; Schauerman, Christopher; Ganter, Mathew; hide

    2017-01-01

    NASA Glenn Research Center (GRC) has a long history related to the development of advanced power technology for space applications. This expertise covers the breadth of energy generation (photovoltaics, thermal energy conversion, etc.), energy storage (batteries, fuel cell technology, etc.), power management and distribution, and power systems architecture and analysis. Such advanced technology is now being developed for small satellite and cubesat applications and could have a significant impact on the longevity and capabilities of these missions. A presentation during the Pre-Conference Workshop will focus on various advanced power technologies being developed and demonstrated by NASA, and their possible application within the small satellite community.

  19. Multiple Coordination Exchanges for Room-Temperature Activation of Open-Metal Sites in Metal-Organic Frameworks.

    Science.gov (United States)

    Bae, Jinhee; Choi, Jae Sun; Hwang, Sunhyun; Yun, Won Seok; Song, Dahae; Lee, JaeDong; Jeong, Nak Cheon

    2017-07-26

    The activation of open coordination sites (OCSs) in metal-organic frameworks (MOFs), i.e., the removal of solvent molecules coordinated at the OCSs, is an essential step that is required prior to the use of MOFs in potential applications such as gas chemisorption, separation, and catalysis because OCSs often serve as key sites in these applications. Recently, we developed a "chemical activation" method involving dichloromethane (DCM) treatment at room temperature, which is considered to be a promising alternative to conventional thermal activation (TA), because it does not require the application of external thermal energy, thereby preserving the structural integrity of the MOFs. However, strongly coordinating solvents such as N,N-dimethylformamide (DMF), N,N-diethylformamide (DEF), and dimethyl sulfoxide (DMSO) are difficult to remove solely with the DCM treatment. In this report, we demonstrate a multiple coordination exchange (CE) process executed initially with acetonitrile (MeCN), methanol (MeOH), or ethanol (EtOH) and subsequently with DCM to achieve the complete activation of OCSs that possess strong extracoordination. Thus, this process can serve as an effective "chemical route" to activation at room temperature that does not require applying heat. To the best of our knowledge, no previous study has demonstrated the activation of OCSs using this multiple CE process, although MeOH and/or DCM has been popularly used in pretreatment steps prior to the TA process. Using MOF-74(Ni), we demonstrate that this multiple CE process can safely activate a thermally unstable MOF without inflicting structural damage. Furthermore, on the basis of in situ (1)H nuclear magnetic resonance ((1)H NMR) and Raman studies, we propose a plausible mechanism for the activation behavior of multiple CE.

  20. Activation of protein kinase A and exchange protein directly activated by cAMP promotes adipocyte differentiation of human mesenchymal stem cells

    DEFF Research Database (Denmark)

    Jia, Bingbing; Madsen, Lise; Petersen, Rasmus Koefoed;

    2012-01-01

    Human mesenchymal stem cells are primary multipotent cells capable of differentiating into several cell types including adipocytes when cultured under defined in vitro conditions. In the present study we investigated the role of cAMP signaling and its downstream effectors, protein kinase A (PKA......) and exchange protein directly activated by cAMP (Epac) in adipocyte conversion of human mesenchymal stem cells derived from adipose tissue (hMADS). We show that cAMP signaling involving the simultaneous activation of both PKA- and Epac-dependent signaling is critical for this process even in the presence......(2)) may fully substitute for the cAMP-elevating agent isobutylmethylxanthine (IBMX). Moreover, selective activation of Epac-dependent signaling promoted adipocyte differentiation when the Rho-associated kinase (ROCK) was inhibited. Unlike the case for murine preadipocytes cell lines, long...

  1. Idaho Nuclear Technology and Engineering Center Low-Activity Waste Process Technology Program FY-98 Status Report

    Energy Technology Data Exchange (ETDEWEB)

    Herbst, Alan Keith; Mc Cray, John Alan; Rogers, Adam Zachary; Simmons, R. F.; Palethorpe, S. J.

    1999-03-01

    The Low-Activity Waste Process Technology Program at the Idaho Nuclear Technology and Engineering Center (INTEC) anticipates that large volumes of low-level/low-activity wastes will need to be grouted prior to near-surface disposal. During fiscal year 1998, three grout formulations were studied for low-activity wastes derived from INTEC liquid sodium-bearing waste. Compressive strength and leach results are presented for phosphate bonding cement, acidic grout, and alkaline grout formulations. In an additional study, grout formulations are recommended for stabilization of the INTEC underground storage tank residual heels.

  2. Idaho Nuclear Technology and Engineering Center Low-Activity Waste Process Technology Program, FY-98 Status Report

    Energy Technology Data Exchange (ETDEWEB)

    Herbst, A.K.; Rogers, A.Z.; McCray, J.A.; Simmons, R.F.; Palethorpe, S.J.

    1999-03-01

    The Low-Activity Waste Process Technology Program at the Idaho Nuclear Technology and Engineering Center (INTEC) anticipates that large volumes of low-level/low-activity wastes will need to be grouted prior to near-surface disposal. During fiscal year 1998, three grout formulations were studied for low-activity wastes derived from INTEC liquid sodium-bearing waste. Compressive strength and leach results are presented for phosphate bonding cement, acidic grout, and alkaline grout formulations. In an additional study, grout formulations are recommended for stabilization of the INTEC underground storage tank residual heels.

  3. Idaho Nuclear Technology and Engineering Center Low-Activity Waste Process Technology Program, FY-98 Status Report

    Energy Technology Data Exchange (ETDEWEB)

    Herbst, A.K.; Rogers, A.Z.; McCray, J.A.; Simmons, R.F.; Palethorpe, S.J.

    1999-03-01

    The Low-Activity Waste Process Technology Program at the Idaho Nuclear Technology and Engineering Center (INTEC) anticipates that large volumes of low-level/low-activity wastes will need to be grouted prior to near-surface disposal. During fiscal year 1998, three grout formulations were studied for low-activity wastes derived from INTEC liquid sodium-bearing waste. Compressive strength and leach results are presented for phosphate bonding cement, acidic grout, and alkaline grout formulations. In an additional study, grout formulations are recommended for stabilization of the INTEC underground storage tank residual heels.

  4. Idaho Nuclear Technology and Engineering Center Low-Activity Waste Process Technology Program FY-98 Status Report

    Energy Technology Data Exchange (ETDEWEB)

    Herbst, A.K.; McCray, J.A.; Rogers, A.Z.; Simmons, R.F.; Palethrope, S.J.

    1999-03-01

    The Low-Activity Waste Process Technology Program at the Idaho Nuclear Technology and Engineering Center (INTEC) anticipates that large volumes of low-level/low-activity wastes will need to be grouted prior to near-surface disposal. During fiscal year 1998, three grout formulations were studied for low-activity wastes derived from INTEC liquid sodium-bearing waste. Compressive strength and leach results are presented for phosphate bonding cement, acidic grout, and alkaline grout formulations. In an additional study, grout formulations are recommended for stabilization of the INTEC underground storage tank residual heels.

  5. Active and Passive Technology Integration: A Novel Approach for Managing Technology's Influence on Learning Experiences in Context-Aware Learning Spaces

    Science.gov (United States)

    Laine, Teemu H.; Nygren, Eeva

    2016-01-01

    Technology integration is the process of overcoming different barriers that hinder efficient utilisation of learning technologies. The authors divide technology integration into two components based on technology's role in the integration process. In active integration, the technology integrates learning resources into a learning space, making it…

  6. Refinery Sugar Decolor Process:Comparision between Ion Exchanger and Active Carbon Process%精制糖脱色工艺-树脂与活性炭脱色技术经济性对比

    Institute of Scientific and Technical Information of China (English)

    BRICHANT Damien; 袁斌; 陈贻虎

    2016-01-01

    综合精制糖脱色技术领域会议报告与实际运行数据,主要介绍了脱色介质活性炭和离子交换树脂的区别,分析天然色素和糖液加工中产生色素的类型、分子量、色素含量等特性,同时研究和讨论空间结构效应、范德华力、疏水作用、离子交换、氢键作用等不同的脱色原理。在此基础上进行活性炭和离子交换脱色工艺优缺点的全面对比,并作出2种工艺运行成本分析,得出离子交换结合卤水膜回收工艺运行成本为0.85~1.20美元/t糖(1000 t糖/天),同时满足不同进料糖液的色值要求,且设计更灵活、更高效,是制糖工业脱色主流工艺技术。%This article combined lots of decolorization technology of refinery sugar and real production data, mainly introduced decolor intermediate on active carbon and ion exchange resin, analyzed color type, mole weight, color contents in natural color and sugar producing byproduct color, and discussed the different decolor principle on space structure effect, intermolecular force, hydrophobic interaction, ion exchange, H bond interaction. Compared technology advantage and disadvantage of two different decolorization process on active carbon and ion exchange resin, ion exchange resin integrate with salts recovery NF (Nano-filtration) system could get running cost to 0.85~1.20 dollar/t-sugar(1000 t/d sugar), and ion exchange decolor process was more flexible and efficiency technical to be a global refinery sugar main employed technology.

  7. The origins of enhanced activity in factor VIIa analogs and the interplay between key allosteric sites revealed by hydrogen exchange mass spectrometry

    DEFF Research Database (Denmark)

    Rand, Kasper D; Andersen, Mette D; Olsen, Ole H;

    2008-01-01

    to investigate the conformational effects of site-directed mutagenesis at key positions in FVIIa and the origins of enhanced intrinsic activity of FVIIa analogs. The differences in hydrogen exchange of two highly active variants, FVIIa(DVQ) and FVIIa(VEAY), imply that enhanced catalytic efficiency was attained...

  8. Teachers' Activities in Technology-Based Mathematics Lessons

    Science.gov (United States)

    Monaghan, John

    2004-01-01

    This paper focuses on high school mathematics teachers and what they do when they use digital technology in their lessons. It is essentially a discursive paper but it uses data from a project on teachers using technology to illustrate points. The main aim of the paper is to present an holistic account of factors influencing teachers' practice. A…

  9. TRIZ TECHNOLOGY FORECASTING AS QFD INPUT WITHIN THE NPD ACTIVITIES

    Institute of Scientific and Technical Information of China (English)

    Coulibaly Solomani; Hua Zhongsheng; Shi Qin; Wang Wei

    2004-01-01

    As a result of the fierceness of business competition,companies,to remain competitive,have to charm their customers by anticipating their needs and being able to rapidly develop exciting new products for them.To overcome this challenge,technology forecasting is considered as a powerful tool in today's business environment,while there are as many success stories as there are failures,a good application of this method will give a good result.A methodology of integration of patterns or lines of technology evolution in TRIZ parlance is presented,which is also known as TRIZ technology forecasting,as input to the QFD process to design a new product.For this purpose,TRIZ technology forecasting,one of the TRIZ major tools,is discussed and some benefits compared to the traditional forecasting techniques are highlighted.Then a methodology to integrate TRIZ technology forecasting and QFD process is highlighted.

  10. Single strand annealing and ATP-independent strand exchange activities of yeast and human DNA2: possible role in Okazaki fragment maturation.

    Science.gov (United States)

    Masuda-Sasa, Taro; Polaczek, Piotr; Campbell, Judith L

    2006-12-15

    The Dna2 protein is a multifunctional enzyme with 5'-3' DNA helicase, DNA-dependent ATPase, 3' exo/endonuclease, and 5' exo/endonuclease. The enzyme is highly specific for structures containing single-stranded flaps adjacent to duplex regions. We report here two novel activities of both the yeast and human Dna2 helicase/nuclease protein: single strand annealing and ATP-independent strand exchange on short duplexes. These activities are independent of ATPase/helicase and nuclease activities in that mutations eliminating either nuclease or ATPase/helicase do not inhibit strand annealing or strand exchange. ATP inhibits strand exchange. A model rationalizing the multiple catalytic functions of Dna2 and leading to its coordination with other enzymes in processing single-stranded flaps during DNA replication and repair is presented.

  11. Changes in soluble interleukin-2 receptor level in serumand Na+ -K+- exchanging ATPase activity in semen of infertile men caused by antisperm antibody

    Institute of Scientific and Technical Information of China (English)

    JiangNI; Qing-LeiLI; WeiZHANG; Jian-SongXIE; Shu-LingBIAN

    2000-01-01

    Aim: To explore the possible mechanisms of male infertility caused by antisperm antibody (AsAb). Methods: The soluble interleukin-2 receptor (sIL-2R) level in serum was analyzed by ELISA and Na+ -K+ -exchanging ATPase activity in semen by phosphorus (Pi) assay. Results: The sIL-2R level in serum was significantly higher and the Na+-K+- exchanging ATPase activity in semen significantly lower in AsAb positive infertile men when compared with the controls. Conclusion: The AsAb titer varies with the sIL-2R level in serum. A decrease in Na+-K+-exchanging ATPase activity in semen may play a role in male infertility caused by AsAb.

  12. Operating revenue changes in a demutualized stock exchange

    Directory of Open Access Journals (Sweden)

    Mohamed Hesham Abdel-Hafez

    2015-03-01

    Full Text Available Stock exchanges were traditionally run as cooperative venues. The globalization, the development of technology, and the increase of competition among stock exchanges forced these venues to change their structure and adopt a new one-demutualization- that can be a lifeline in facing these environmental changes in regards to stock exchanges. This new trend enables the exchange to expand their activities and supply the market with new products and services, therefore enhancing the value of the exchange itself. The main sources of revenue for traditional exchanges have been listing fees, transaction fees, membership fees and the sale of information services such as market data, quotations, and trade data. Due to the environmental changes the stock exchanges' services are now executed electronically, and in turn, this has led to an increase in the competition among exchanges. Furthermore, this increased competition has led to the re-adjustment of the regulation structure which gradually erodes the sources of revenues provided by the conventional stock exchanges. The paper divided the research plan into two sections: the first section is to highlight the concept of demutualization process; the phases of demutualization, the factors that push the stock exchanges to demutualize and the benefits of demutualization. The second section was based on statistical comparative analysis of the stock exchanges' revenues prior and after demutualization. The researcher used the regression analysis tool on seven demutualized stock exchanges during the period from 1997-2012. The paper aims to prove that demutualization has a positive effect on the revenues of the stock exchange, thus it enhances the value of the exchange.

  13. How Does Technology-Enabled Active Learning Affect Undergraduate Students' Understanding of Electromagnetism Concepts?

    Science.gov (United States)

    Dori, Yehudit Judy; Belcher, John

    2005-01-01

    Educational technology supports meaningful learning and enables the presentation of spatial and dynamic images, which portray relationships among complex concepts. The Technology-Enabled Active Learning (TEAL) Project at the Massachusetts Institute of Technology (MIT) involves media-rich software for simulation and visualization in freshman…

  14. The technical analysis of the stock exchange and physics: Japanese candlesticks for solar activity

    Science.gov (United States)

    Dineva, C.; Atanasov, V.

    2013-09-01

    In this article, we use the Japanese candlesticks, a method popular in the technical analysis of the Stock/Forex markets and apply it to a variable in physics-the solar activity. This method is invented and used exclusively for economic analysis and its application to a physical problem produced unexpected results. We found that the Japanese candlesticks are convenient tool in the analysis of the variables in the physics of the Sun. Based on our observations, we differentiated a new cycle in the solar activity.

  15. A Review of Technology Education in Ireland; a Changing Technological Environment Promoting Design Activity

    Science.gov (United States)

    Leahy, Keelin; Phelan, Pat

    2014-01-01

    In Ireland, Technology Education's structure and organisation across the levels of education is not delivered or governed in a coherent manner. Technology Education in primary level education, for students between 5 and 12 years of age, does not explicitly exist as a separate subject. In primary level education, Social, Environmental and…

  16. A Review of Technology Education in Ireland; a Changing Technological Environment Promoting Design Activity

    Science.gov (United States)

    Leahy, Keelin; Phelan, Pat

    2014-01-01

    In Ireland, Technology Education's structure and organisation across the levels of education is not delivered or governed in a coherent manner. Technology Education in primary level education, for students between 5 and 12 years of age, does not explicitly exist as a separate subject. In primary level education, Social, Environmental and…

  17. Evaluation of the feasibility of security technologies in teleradiology as biometric fingerprint scanners for data exchange over a satellite WAN

    Science.gov (United States)

    Soegner, Peter I.; Helweg, Gernot; Holzer, Heimo; zur Nedden, Dieter

    2000-05-01

    We evaluated the feasibility of fingerprint-scanners in combination with smart cards for personal identification and transmission of encrypted TCP/IP-data-packages via satellite between the university-hospital of Innsbruck and the rural hospital of Reutte. The aim of our study was the proof of the userfriendliness of the SkymedTM technology for security purpose in teleradiology. We examined the time of the personal identification process, the time for the necessary training and the personal satisfaction. The images were sent from the local PACS in Reutte via a Data-Encryption-and-Transmission- Box via satellite from Reutte to Innsbruck. We used an asymmetric bandwidth of 512 kbit/s from Reutte to Innsbruck and 128 kbit/s in the opposite direction. Window NT 4.0- operating PCs were used for the electronical patient record, the medical inquiry of the referring physician and the final report of the radiologist. The images were reported on an UNIX-PACS viewing station. After identification through fingerprint-scanners in combination with the smart card the radiologist was able to open the electronic patient record (EPR) from Reutte and sign with his digital signature his confirmed final report before it was send back to Reutte. The used security technology enables encrypted communication over a WAN, which fulfill data-protection.

  18. Activation of Na+/H+ and K+/H+ exchange by calyculin A in Amphiuma tridactylum red blood cells: implications for the control of volume-induced ion flux activity

    Science.gov (United States)

    Ortiz-Acevedo, Alejandro; Rigor, Robert R.; Maldonado, Hector M.; Cala, Peter M.

    2008-01-01

    Alteration in cell volume of vertebrates results in activation of volume-sensitive ion flux pathways. Fine control of the activity of these pathways enables cells to regulate volume following osmotic perturbation. Protein phosphorylation and dephosphorylation have been reported to play a crucial role in the control of volume-sensitive ion flux pathways. Exposing Amphiuma tridactylu red blood cells (RBCs) to phorbol esters in isotonic medium results in a simultaneous, dose-dependent activation of both Na+/H+ and K+/H+ exchangers. We tested the hypothesis that in Amphiuma RBCs, both shrinkage-induced Na+/H+ exchange and swelling-induced K+/H+ exchange are activated by phosphorylation-dependent reactions. To this end, we assessed the effect of calyculin A, a phosphatase inhibitor, on the activity of the aforementioned exchangers. We found that exposure of Amphiuma RBCs to calyculin-A in isotonic media results in simultaneous, 1–2 orders of magnitude increase in the activity of both K+/H+ and Na+/H+ exchangers. We also demonstrate that, in isotonic media, calyculin A-dependent increases in net Na+ uptake and K+ loss are a direct result of phosphatase inhibition and are not dependent on changes in cell volume. Whereas calyculin A exposure in the absence of volume changes results in stimulation of both the Na+/H+ and K+/H+ exchangers, superimposing cell swelling or shrinkage and calyculin A treatment results in selective activation of K+/H+ or Na+/H+ exchange, respectively. We conclude that kinase-dependent reactions are responsible for Na+/H+ and K+/H+ exchange activity, whereas undefined volume-dependent reactions confer specificity and coordinated control. PMID:18799654

  19. Effective elimination of organic matter interference in boron isotopic analysis by thermal ionization mass spectrometry of coral/foraminifera: micro-sublimation technology combined with ion exchange.

    Science.gov (United States)

    He, Maoyong; Xiao, Yingkai; Ma, Yunqi; Jin, Zhangdong; Xiao, Jun

    2011-03-30

    In order to better estimate the effectiveness of micro-sublimation technology on the elimination of organic matter interference during boron isotopic analysis, a series of improved experiments was carried out using simple apparatus. Recovery rates after micro-sublimation were measured for boric acid solutions with different B contents or different B/organic matter ratios. The improved micro-sublimation procedure combined with ion-exchange technology was then used to test natural samples (coral and foraminifera) for the separation of boron. Our results show that the time taken for 100% recovery of different amounts of B differed and that the proportions of B/organic matter within the natural organic matter have little effect on the relationship between the recovery rates of B and the micro-sublimation times. The experiments further confirm that the organic matter does indeed have an effect on boron isotope analyses by positive thermal ionization mass spectrometry and that the use of micro-sublimation can effectively remove interferences from the organic matter during boron isotopic analysis.

  20. Mobile satellite communications technology - A summary of NASA activities

    Science.gov (United States)

    Dutzi, E. J.; Knouse, G. H.

    1986-01-01

    Studies in recent years indicate that future high-capacity mobile satellite systems are viable only if certain high-risk enabling technologies are developed. Accordingly, NASA has structured an advanced technology development program aimed at efficient utilization of orbit, spectrum, and power. Over the last two years, studies have concentrated on developing concepts and identifying cost drivers and other issues associated with the major technical areas of emphasis: vehicle antennas, speech compression, bandwidth-efficient digital modems, network architecture, mobile satellite channel characterization, and selected space segment technology. The program is now entering the next phase - breadboarding, development, and field experimentation.

  1. Rac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiam1

    NARCIS (Netherlands)

    Van Leeuwen, Frank N; Olivo, Cristina; Grivell, Shula; Giepmans, Ben N G; Collard, John G; Moolenaar, Wouter H

    2003-01-01

    Lysophosphatidic acid (LPA) is a serum-borne phospholipid that activates its own G protein-coupled receptors present in numerous cell types. In addition to stimulating cell proliferation, LPA also induces cytoskeletal changes and promotes cell migration in a RhoA- and Rac-dependent manner. Whereas R

  2. Cyclic AMP-guanine exchange factor activation inhibits JNK-dependent lipopolysaccharide-induced apoptosis in rat hepatocytes

    Directory of Open Access Journals (Sweden)

    Kathleen Ponzetti

    2010-01-01

    Full Text Available Kathleen Ponzetti1, Melissa King1, Anna Gates1, M Sawkat Anwer2, Cynthia RL Webster11Department of Clinical Science, Tufts Cummings School of Veterinary Medicine, Grafton MA, USA; 2Department of Biomedical Sciences, Tufts Cummings School of Veterinary Medicine, Grafton MA, USAAbstract: Lipopolysaccharide (LPS is known to damage hepatocytes by cytokines released from activated Kupffer cells, but the ancillary role of LPS as a direct hepatotoxin is less well characterized. The aim of this study was to determine the direct effect of LPS on hepatocyte viability and the underlying signaling mechanism. Rat hepatocyte cultures treated overnight with LPS (500 ng/mL induced apoptosis as monitored morphologically (Hoechst 33258 and biochemically (cleavage of caspase 3 and 9 and the appearance of cytochrome C in the cytoplasm. LPS-induced apoptosis was additive to that induced by glycochenodeoxycholate or Fas ligand, was associated with activation of c-Jun N-terminal kinase B (JNK and p38 mitogenactivated protein kinases (MAPK, and inhibition of protein kinase (AKT. Inhibition of JNK by SP600125, but not of p38 MAPK by SB203580 attenuated LPS-induced apoptosis, indicating JNK dependency. CPT-2-Me-cAMP, an activator of cAMP-GEF, decreased apoptosis due to LPS alone or in combination with glycochenodeoxycholate or Fas ligand. CPT-2-Me-cAMP also prevented LPS-induced activation of JNK and inhibition of AKT. Taken together, these results suggest that LPS can induce hepatocyte apoptosis directly in vitro in a JNK-dependent manner and activation of cAMP-GEF protects against the LPS-induced apoptosis most likely by reversing the effect of LPS on JNK and AKT.Keywords: apoptosis, cAMP-GEF, AKT, exchange protein activated by cAMP (EPAC, lipopolysaccharide, JNK

  3. Identification and function of exchange proteins activated directly by cyclic AMP (Epac in mammalian spermatozoa.

    Directory of Open Access Journals (Sweden)

    Alvaro Miro-Moran

    Full Text Available The role of cAMP in spermatic functions was classically thought to be mediated exclusively through the activation of Protein Kinase A (PKA. However, it has recently been shown that cAMP also exerts its effects through a PKA-independent pathway activating a family of proteins known as Epac proteins. Therefore, many of the spermatic functions thought to be regulated by cAMP through the activation of PKA are again under study. We aimed to identify and to investigate the role of Epac proteins in spermatozoa using a specific permeable analog (8-Br-2'-O-Me-cAMP. Also, we aimed to study its relationship with E-cadherin, an adhesion protein involved in fertility. Our results demonstrate the presence and sub-cellular distribution of Epac 1 and Epac 2 in mammalian spermatozoa. Capacitation and the acrosome reaction induced a change in the localization of Epac proteins in sperm. Moreover, incubation with 8-Br-2'-O-Me-cAMP prompted an increase in Rap1 activation, in the scrambling of plasma membrane phospholipids (necessary for the capacitation process, the acrosome reaction, motility, and calcium mobilization, when spermatozoa were incubated in acrosome reaction conditions. Finally, the activation of Epac proteins induced a change in the distribution of E-cadherin. Therefore, the increase in the acrosome reaction, together with the increase in calcium (which is known to be essential for fertilization and the Epac nteraction with E-cadherin, might indicate that Epac proteins have an important role in gamete recognition and fertilization.

  4. TECHNOLOGIES OF INITIATING STUDENTS INTO INDEPENDENT (SELF-GUIDED ACTIVITY IN SUPPLEMENTARY DISTANCE LEARNING

    Directory of Open Access Journals (Sweden)

    Irina V. Abakumova

    2016-12-01

    Full Text Available The research in question investigates the technologies of initiating independent activity within the framework of distance learning and their psychological aspects. The authors’ classification of educational technologies of initiating students into independent cognitive activity is presented. Such technologies utilize various psychological mechanisms of exciting students’ cognitive interest, intensifying cognitive processes, developing independent activity skills, and, as a result, increase motivation for independent activity and learning on the whole. These include such types of technologies as developmental technologies, interactive technologies, technologies of information transfer, technologies of meaning-making initiation. The research of the attitude of distance learning educators to independent activity of students and the content of the academic courses were done at Moodle-based education programs. The findings show the differences in retention rate among distance learning educators whose competence in terms of initiating students into independent (self-guided activity varies. It’s emphasized that interactive lectures, videoconferences, audio-visual aids, interactive seminars, glossaries, interactive tests are considered the most efficient technologies in initiating students into independent (self-guided activity. The obtained results have made it possible to stress the developmental effect of distance learning technologies and the technologies of initiating students into independent (self-guided activity in various psychic spheres of students: cognitive, individual, emotional. We mention the changes in motivational sphere of students and their meaning-making activity. In the course of correct development of distance learning we notice the development of voluntary and nonvoluntary cognitive activity. A student starts actively participating in educational process, he becomes the creator of his own world.

  5. Na/H Exchanger Regulatory Factors Control Parathyroid Hormone Receptor Signaling by Facilitating Differential Activation of Gα Protein Subunits*

    Science.gov (United States)

    Wang, Bin; Ardura, Juan A.; Romero, Guillermo; Yang, Yanmei; Hall, Randy A.; Friedman, Peter A.

    2010-01-01

    The Na/H exchanger regulatory factors, NHERF1 and NHERF2, are adapter proteins involved in targeting and assembly of protein complexes. The parathyroid hormone receptor (PTHR) interacts with both NHERF1 and NHERF2. The NHERF proteins toggle PTHR signaling from predominantly activation of adenylyl cyclase in the absence of NHERF to principally stimulation of phospholipase C when the NHERF proteins are expressed. We hypothesized that this signaling switch occurs at the level of the G protein. We measured G protein activation by [35S]GTPγS binding and Gα subtype-specific immunoprecipitation using three different cellular models of PTHR signaling. These studies revealed that PTHR interactions with NHERF1 enhance receptor-mediated stimulation of Gαq but have no effect on stimulation of Gαi or Gαs. In contrast, PTHR associations with NHERF2 enhance receptor-mediated stimulation of both Gαq and Gαi but decrease stimulation of Gαs. Consistent with these functional data, NHERF2 formed cellular complexes with both Gαq and Gαi, whereas NHERF1 was found to interact only with Gαq. These findings demonstrate that NHERF interactions regulate PTHR signaling at the level of G proteins and that NHERF1 and NHERF2 exhibit isotype-specific effects on G protein activation. PMID:20562104

  6. Integrating hydraulic conductivity with biogeochemical gradients and microbial activity along river-groundwater exchange zones in a subtropical stream

    Science.gov (United States)

    Claret, Cécile; Boulton, Andrew J.

    2009-02-01

    The pervious lateral bars (parafluvial zone) and beds (hyporheic zone), where stream water and groundwater exchange, are dynamic sites of hydrological and biological retention. The significance of these biogeochemical ‘hotspots’ to stream and groundwater metabolism is largely controlled by filtration capacity, defined as the extent to which subsurface flowpaths and matrix hydraulic conductivity modify water characteristics. Where hydraulic conductivity is high, gradients in biogeochemistry and microbial activity along subsurface flowpaths were hypothesized to be less marked than where hydraulic conductivity is low. This hypothesis was tested in two riffles and gravel bars in an Australian subtropical stream. At one site, gradients in chemical and microbial variables along flowpaths were associated with reduced hydraulic conductivity, longer water residence time and reduced filtration capacity compared with the second site where filtration capacity was greater and longitudinal biogeochemical trends were dampened. These results imply that factors affecting the sediment matrix in this subtropical stream can alter filtration capacity, interstitial microbial activity and biogeochemical gradients along subsurface flowpaths. This hydroecological approach also indicates potential for a simple field technique to estimate filtration capacity and predict the prevailing hyporheic gradients in microbial activity and biogeochemical processing efficiency, with significant implications for stream ecosystem function.

  7. A high throughput gas exchange screen for determining rates of photorespiration or regulation of C4 activity.

    Science.gov (United States)

    Bellasio, Chandra; Burgess, Steven J; Griffiths, Howard; Hibberd, Julian M

    2014-07-01

    Large-scale research programmes seeking to characterize the C4 pathway have a requirement for a simple, high throughput screen that quantifies photorespiratory activity in C3 and C4 model systems. At present, approaches rely on model-fitting to assimilatory responses (A/C i curves, PSII quantum yield) or real-time carbon isotope discrimination, which are complicated and time-consuming. Here we present a method, and the associated theory, to determine the effectiveness of the C4 carboxylation, carbon concentration mechanism (CCM) by assessing the responsiveness of V O/V C, the ratio of RuBisCO oxygenase to carboxylase activity, upon transfer to low O2. This determination compares concurrent gas exchange and pulse-modulated chlorophyll fluorescence under ambient and low O2, using widely available equipment. Run time for the procedure can take as little as 6 minutes if plants are pre-adapted. The responsiveness of V O/V C is derived for typical C3 (tobacco, rice, wheat) and C4 (maize, Miscanthus, cleome) plants, and compared with full C3 and C4 model systems. We also undertake sensitivity analyses to determine the impact of R LIGHT (respiration in the light) and the effectiveness of the light saturating pulse used by fluorescence systems. The results show that the method can readily resolve variations in photorespiratory activity between C3 and C4 plants and could be used to rapidly screen large numbers of mutants or transformants in high throughput studies.

  8. Technology station in electronics at the Tshwane University of Technology: strengthening technological innovation activities amongst SMEs and students

    CSIR Research Space (South Africa)

    Jacobs, SJ

    2009-01-01

    Full Text Available This article focuses on how the competence and capacity within the Faculty of Engineering and the Built Environment, specifically the electronic/electrical discipline, at the Tshwane University of Technology is utilised to support Small Medium...

  9. Heat exchanger design handbook

    CERN Document Server

    Thulukkanam, Kuppan

    2013-01-01

    Completely revised and updated to reflect current advances in heat exchanger technology, Heat Exchanger Design Handbook, Second Edition includes enhanced figures and thermal effectiveness charts, tables, new chapter, and additional topics--all while keeping the qualities that made the first edition a centerpiece of information for practicing engineers, research, engineers, academicians, designers, and manufacturers involved in heat exchange between two or more fluids.See What's New in the Second Edition: Updated information on pressure vessel codes, manufacturer's association standards A new c

  10. Forecasting of innovative activity on the basis of application of technology of Foresight

    Directory of Open Access Journals (Sweden)

    Nazarova Natalia Leonidovna

    2011-10-01

    Full Text Available In article the basic questions of forecasting of innovative activity of economic systems are considered. Forsyte's bases are considered. Necessity, importance, success of application of technology of Forsyte for forecasting of innovative activity are proved.

  11. TECHNOLOGY AND INNOVATION IN HUMAN ACTIVITY OF THE INFORMATION AGE: INFORMATION CHALLENGES AND TECHNOLOGIES

    Directory of Open Access Journals (Sweden)

    Oleksandr Yu. Burov

    2015-10-01

    Full Text Available It is discussed the role of technology development, especially in connection with social transformation and transition of humanity to the era of information/knowledge, analyzed the trend accelerating technological change and its relation to civil and military changes in society. It is emphasized the fundamental novelty of the information age, namely the transition of mankind from the production of material products mainly to intangible (information, knowledge, human cognitive processes. It is emphasized that ICT gain not only growing importance, but become a driving force of human civilization. The basic features of education in the information age, including ICT educational purpose out technology for distance education are described.

  12. Fiscal 2000 survey of geological structures overseas. Exchange of engineers with Vietnam (Coal mining technology); 2000 nendo kaigai chishitsu kozo nado chosa hokokusho. Gijutsusha koryu jigyo (tanko gijutsu bun'ya) Vietnam

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    A coal mining engineer exchange project was implemented by Japan and Vietnam for improving on coal mining engineers' production and management technologies in the Asia-Pacific region. Six engineers were dispatched to Hon Cam Training School for mine workers, Hon Gai, where they taught in the period November 12 through December 2, 2000. There were 18 trainees, to whom lectures were given on 16 subjects including the steep slope mining method, excavation technology, transportation technology, ventilation control technology, production control technology, quality control technology, cost and material control, risk control, and centralized monitoring technology. Discussion was also held on the subjects. Ten trainees were invited and received mainly by Taiheiyo Coal Mining Corporation for the period August 24 through September 9, 2000, where they were given lectures and underwent training in the mine. The trainees also visited Isoko Power Station, Coal Research Institute of Idemitsu Kosan Co., Ltd., and Kushiro Plant of Nippon Paper Industries Co., Ltd. (NEDO)

  13. Idaho Nuclear Technology and Engineering Center Low-Activity Waste Process Technology Program FY-99 Status Report

    Energy Technology Data Exchange (ETDEWEB)

    Herbst, Alan Keith; Mc Cray, John Alan; Kirkham, Robert John; Pao, Jenn Hai; Hinckley, Steve Harold

    1999-10-01

    The Low-Activity Waste Process Technology Program at the Idaho Nuclear Technology and Engineering Center (INTEC) anticipates that large volumes of low-level/low-activity wastes will need to be grouted prior to near-surface disposal. During fiscal year 1999, grout formulations were studied for transuranic waste derived from INTEC liquid sodium-bearing waste and for projected newly generated low-level liquid waste. Additional studies were completed on radionuclide leaching, microbial degradation, waste neutralization, and a small mockup for grouting the INTEC underground storage tank residual heels.

  14. Idaho Nuclear Technology and Engineering Center Low-Activity Waste Process Technology Program FY-99 Status Report

    Energy Technology Data Exchange (ETDEWEB)

    A. K. Herbst; J. A. McCray; R. J. Kirkham; J. Pao; S. H. Hinckley

    1999-09-30

    The Low-Activity Waste Process Technology Program at the Idaho Nuclear Technology and Engineering Center (INTEC) anticipates that large volumes of low-level/low-activity wastes will need to be grouted prior to near-surface disposal. During fiscal year 1999, grout formulations were studied for transuranic waste derived from INTEC liquid sodium-bearing waste and for projected newly generated low-level liquid waste. Additional studies were completed on radionuclide leaching, microbial degradation, waste neutralization, and a small mockup for grouting the INTEC underground storage tank residual heels.

  15. Oil atlas: National Petroleum Technology Office activities across the United States

    Energy Technology Data Exchange (ETDEWEB)

    Tiedemann, H.A.

    1998-03-01

    Petroleum imports account for the largest share of the US trade deficit. Over one-third of the 1996 merchandise trade deficit is attributed to imported oil. The good news is that substantial domestic oil resources, both existing and yet-to-be-discovered, can be recovered using advanced petroleum technologies. The Energy Information Agency estimates that advanced technologies can yield 10 billion additional barrels, equal to $240 billion in import offsets. The US Department of Energy`s National Petroleum Technology Office works with industry to develop advanced petroleum technologies and to transfer successful technologies to domestic oil producers. This publication shows the locations of these important technology development efforts and lists DOE`s partners in this critical venture. The National Petroleum Technology Office has 369 active technology development projects grouped into six product lines: Advanced Diagnostics and Imaging Systems; Advanced Drilling, Completion, and Stimulation; Reservoir Life Extension and Management; Emerging Processing Technology Applications; Effective Environmental Protection; and Crosscutting Program Areas.

  16. Assessing gibberellins oxidase activity by anion exchange/hydrophobic polymer monolithic capillary liquid chromatography-mass spectrometry.

    Science.gov (United States)

    Chen, Ming-Luan; Su, Xin; Xiong, Wei; Liu, Jiu-Feng; Wu, Yan; Feng, Yu-Qi; Yuan, Bi-Feng

    2013-01-01

    Bioactive gibberellins (GAs) play a key regulatory role in plant growth and development. In the biosynthesis of GAs, GA3-oxidase catalyzes the final step to produce bioactive GAs. Thus, the evaluation of GA3-oxidase activity is critical for elucidating the regulation mechanism of plant growth controlled by GAs. However, assessing catalytic activity of endogenous GA3-oxidase remains challenging. In the current study, we developed a capillary liquid chromatography--mass spectrometry (cLC-MS) method for the sensitive assay of in-vitro recombinant or endogenous GA3-oxidase by analyzing the catalytic substrates and products of GA3-oxidase (GA1, GA4, GA9, GA20). An anion exchange/hydrophobic poly([2-(methacryloyloxy)ethyl]trimethylammonium-co-divinylbenzene-co-ethylene glycol dimethacrylate)(META-co-DVB-co-EDMA) monolithic column was successfully prepared for the separation of all target GAs. The limits of detection (LODs, Signal/Noise = 3) of GAs were in the range of 0.62-0.90 fmol. We determined the kinetic parameters (K m) of recombinant GA3-oxidase in Escherichia coli (E. coli) cell lysates, which is consistent with previous reports. Furthermore, by using isotope labeled substrates, we successfully evaluated the activity of endogenous GA3-oxidase that converts GA9 to GA4 in four types of plant samples, which is, to the best of our knowledge, the first report for the quantification of the activity of endogenous GA3-oxidase in plant. Taken together, the method developed here provides a good solution for the evaluation of endogenous GA3-oxidase activity in plant, which may promote the in-depth study of the growth regulation mechanism governed by GAs in plant physiology.

  17. Assessing gibberellins oxidase activity by anion exchange/hydrophobic polymer monolithic capillary liquid chromatography-mass spectrometry.

    Directory of Open Access Journals (Sweden)

    Ming-Luan Chen

    Full Text Available Bioactive gibberellins (GAs play a key regulatory role in plant growth and development. In the biosynthesis of GAs, GA3-oxidase catalyzes the final step to produce bioactive GAs. Thus, the evaluation of GA3-oxidase activity is critical for elucidating the regulation mechanism of plant growth controlled by GAs. However, assessing catalytic activity of endogenous GA3-oxidase remains challenging. In the current study, we developed a capillary liquid chromatography--mass spectrometry (cLC-MS method for the sensitive assay of in-vitro recombinant or endogenous GA3-oxidase by analyzing the catalytic substrates and products of GA3-oxidase (GA1, GA4, GA9, GA20. An anion exchange/hydrophobic poly([2-(methacryloyloxyethyl]trimethylammonium-co-divinylbenzene-co-ethylene glycol dimethacrylate(META-co-DVB-co-EDMA monolithic column was successfully prepared for the separation of all target GAs. The limits of detection (LODs, Signal/Noise = 3 of GAs were in the range of 0.62-0.90 fmol. We determined the kinetic parameters (K m of recombinant GA3-oxidase in Escherichia coli (E. coli cell lysates, which is consistent with previous reports. Furthermore, by using isotope labeled substrates, we successfully evaluated the activity of endogenous GA3-oxidase that converts GA9 to GA4 in four types of plant samples, which is, to the best of our knowledge, the first report for the quantification of the activity of endogenous GA3-oxidase in plant. Taken together, the method developed here provides a good solution for the evaluation of endogenous GA3-oxidase activity in plant, which may promote the in-depth study of the growth regulation mechanism governed by GAs in plant physiology.

  18. Game Changing Development Program - Next Generation Life Support Project: Oxygen Recovery From Carbon Dioxide Using Ion Exchange Membrane Electrolysis Technology

    Science.gov (United States)

    Burke, Kenneth A.; Jiao, Feng

    2016-01-01

    This report summarizes the Phase I research and development work performed during the March 13, 2015 to July 13, 2016 period. The proposal for this work was submitted in response to NASA Research Announcement NNH14ZOA001N, "Space Technology Research, Development, Demonstration, and Infusion 2014 (SpaceTech-REDDI-2014)," Appendix 14GCD-C2 "Game Changing Development Program, Advanced Oxygen Recovery for Spacecraft Life Support Systems Appendix" The Task Agreement for this Phase I work is Document Control Number: GCDP-02-TA-15015. The objective of the Phase I project was to demonstrate in laboratories two Engineering Development Units (EDU) that perform critical functions of the low temperature carbon dioxide electrolysis and the catalytic conversion of carbon monoxide into carbon and carbon dioxide. The low temperature carbon dioxide electrolysis EDU was built by the University of Delaware with Dr. Feng Jiao as the principal investigator in charge of this EDU development (under NASA Contract NNC15CA04C). The carbon monoxide catalytic conversion EDU was built by the NASA Glenn Research Center with Kenneth Burke as the principal investigator and overall project leader for the development of both EDUs. Both EDUs were successfully developed and demonstrated the critical functions for each process. The carbon dioxide electrolysis EDU was delivered to the NASA Johnson Space Center and the carbon monoxide catalytic conversion EDU was delivered to the NASA Marshall Spaceflight Center.

  19. Sensing technologies to measure metabolic activities in soil and assess its health conditions

    Science.gov (United States)

    De Cesare, Fabrizio; Macagnano, Antonella

    2013-04-01

    (olfactory fingerprint) typical of the analysed air sample. Due to these features, we decided to apply such a sensing technology to the analyses of soil atmospheres, because several processes in soil, both abiotic and biotic, result in gas and/or volatile production and the dynamics of such releases may also be affected by several additional environmental factors, such as soil moisture, temperature, gas exchange rates with outer atmosphere, adsorption/desorption processes, etc. Then, the analysis of soil atmosphere may provide information about global soil conditions (e.g. soil quality and health), according to a holistic approach, where several factors are contemporarily taken into account. At the same time, the use of such a technology, if adequately trained on purpose, can supply information about a single or a pool of processes sharing similar features, which occur in soil over a certain period of time and mostly affecting soil atmosphere. According to these premises and hypotheses, we demonstrated that EN is an useful technology to measure soil microbial activity, through its correlation to specific metabolic activities occurring in soil (i.e. global and specific respiration and some enzyme activities), but also soil microbial biomass. On the basis of such evidences, we also were able to use this technology to assess the quality and health conditions of soil ecosystems in terms of metabolic indices previously identified, according to some metabolic parameters and biomass quantification of microbial populations. In other studies, we also applied EN technology, despite using a different set of sensors in the array, to analyse the atmosphere of soil ecosystems in order to assess their environmental conditions after contamination with polycyclic aromatic hydrocarbons (PAHs) (i.e. semivolatile - SVOCs - organic pollutants). In this case, EN technology resulted capable of distinguishing between contaminated and uncontaminated soils, according to the differences in a list of

  20. Highly Stable and Active Pt/Nb-TiO2 Carbon-Free Electrocatalyst for Proton Exchange Membrane Fuel Cells

    Directory of Open Access Journals (Sweden)

    Shuhui Sun

    2012-01-01

    Full Text Available The current materials used in proton exchange membrane fuel cells (PEMFCs are not sufficiently durable for commercial deployment. One of the major challenges lies in the development of an inexpensive, efficient, and highly durable and active electrocatalyst. Here a new type of carbon-free Pt/Nb-TiO2 electrocatalyst has been reported. Mesoporous Nb-TiO2 hollow spheres were synthesized by the sol-gel method using polystyrene (PS sphere templates. Pt nanoparticles (NPs were then deposited onto mesoporous Nb-TiO2 hollow spheres via a simple wet-chemical route in aqueous solution, without the need for surfactants or potentiostats. The growth densities of Pt NPs on Nb-TiO2 supports could be easily modulated by simply adjusting the experimental parameters. Electrochemical studies of Pt/Nb-TiO2 show much enhanced activity and stability than commercial E-TEK Pt/C catalyst. PtNP/Nb-TiO2 is a promising new cathode catalyst for PEMFC applications.

  1. Proton exchange membrane fuel cell model for aging predictions: Simulated equivalent active surface area loss and comparisons with durability tests

    Science.gov (United States)

    Robin, C.; Gérard, M.; Quinaud, M.; d'Arbigny, J.; Bultel, Y.

    2016-09-01

    The prediction of Proton Exchange Membrane Fuel Cell (PEMFC) lifetime is one of the major challenges to optimize both material properties and dynamic control of the fuel cell system. In this study, by a multiscale modeling approach, a mechanistic catalyst dissolution model is coupled to a dynamic PEMFC cell model to predict the performance loss of the PEMFC. Results are compared to two 2000-h experimental aging tests. More precisely, an original approach is introduced to estimate the loss of an equivalent active surface area during an aging test. Indeed, when the computed Electrochemical Catalyst Surface Area profile is fitted on the experimental measures from Cyclic Voltammetry, the computed performance loss of the PEMFC is underestimated. To be able to predict the performance loss measured by polarization curves during the aging test, an equivalent active surface area is obtained by a model inversion. This methodology enables to successfully find back the experimental cell voltage decay during time. The model parameters are fitted from the polarization curves so that they include the global degradation. Moreover, the model captures the aging heterogeneities along the surface of the cell observed experimentally. Finally, a second 2000-h durability test in dynamic operating conditions validates the approach.

  2. Short-term 222Rn activity concentration changes in underground spaces with limited air exchange with the atmosphere

    Directory of Open Access Journals (Sweden)

    T. A. Przylibski

    2011-04-01

    Full Text Available The authors investigated short-time changes in 222Rn activity concentration occurring yearly in two underground tourist facilities with limited air exchange with the atmosphere. One of them is Niedźwiedzia (Bear Cave in Kletno, Poland – a natural space equipped with locks ensuring isolation from the atmosphere. The other site is Fluorite Adit in Kletno, a section of a disused uranium mine. This adit is equipped with a mechanical ventilation system, operated periodically outside the opening times (at night. Both sites are situated within the same metamorphic rock complex, at similar altitudes, about 2 km apart. The measurements conducted revealed spring and autumn occurrence of convective air movements. In Bear Cave, this process causes a reduction in 222Rn activity concentration in the daytime, i.e. when tourists, guides and other staff are present in the cave. From the point of view of radiation protection, this is the best situation. For the rest of the year, daily concentrations of 222Rn activity in the cave are very stable. In Fluorite Adit, on the other hand, significant variations in daily 222Rn activity concentrations are recorded almost all year round. These changes are determined by the periods of activity and inactivity of mechanical ventilation. Unfortunately this is inactive in the daytime, which results in the highest values of 222Rn activity concentration at the times when tourists and staff are present in the adit. Slightly lower concentrations of radon in Fluorite Adit are recorded in the winter season, when convective air movements carry a substantial amount of radon out into the atmosphere. The incorrect usage of mechanical ventilation in Fluorite Adit results in the most unfavourable conditions in terms of radiation protection. The staff working in that facility are exposed practically throughout the year to the highest 222Rn activity concentrations, both at work (in the adit and at home (outside their working hours

  3. An Active-Distributed Temperature Sensing method to quantify groundwater - surface water exchanges

    Science.gov (United States)

    Simon, Nataline; Bour, Olivier; Lavenant, Nicolas; Faucheux, Mickaël; Fovet, Ophélie; Longuevergne, Laurent

    2017-04-01

    Understanding and quantifying groundwater and surface water interactions are key elements for the management of water quality and quantity, but also for the preservation of groundwater dependent ecosystems and riparian habitat. We developed a methodology to quantify groundwater and surface water interactions, by setting up an active heat tracer experiment using fiber-optic distributed temperature sensing (FO-DTS). The experimental setup consists in heating an armoured fiber-optic cable that has been previously deployed along the streambed within the sediments. Then, the increase in temperature along the heated cable is a function of the thermal properties of the sediments and of the fluid flow velocity within the sediments. The cable is heated electrically through the steel armouring of the cable while the elevations in temperature are continuously monitored. We tested this methodology on the Kerbernez catchment, located in south-western Brittany (France) and which is part of the AgrHys hydrological observatory. We deploy the cable in a first-order stream within this small agricultural catchment (0.12 km2). Temperature was monitored along 60 meters of stream with a spatial and temporal resolution respectively equal to 29 cm and 30 s. To interpret the data, we used an analytical solution developed for geothermal energy that considers advection and conduction of temperature in porous media. To validate the use of the analytical solution and to define the limits of the method, a 2D numerical model has been developed. This model simulates heat transport and conduction with steady state fluid flow using the Conjugate Heat Transfer module of COMSOL Multiphysics ®. During heating and cooling, the measured temperature was particularly variable along the section with temperature increases that range between 16 to 36°C. This variability can directly be associated with local variations of water fluxes by applying the appropriate analytical solution. Henceforth, it is

  4. Review of atomic data needs for active charge-exchange spectroscopy on ITERa)

    Science.gov (United States)

    Marchuk, O.; Bertschinger, G.; Biel, W.; Delabie, E.; von Hellermann, M. G.; Jaspers, R.; Reiter, D.

    2008-10-01

    The quantitative exploitation of active beam spectra is largely based on an advanced atomic modeling. Under the ITER operating conditions the penetration depth of a diagnostic beam into the plasma core crucially affects the intensities of spectral lines and hence the uncertainties of derived plasma parameters. A critical review of atomic data and an assessment of its error margins are, therefore, urgently needed. The aim of the present work is to verify the existing beam-stopping and beam-emission data for hydrogen beam in fusion plasmas. The agreement between the ADAS database and the present calculations is found to be within 5% for the beam-stopping data in a H-plasma. The calculation of beam attenuation in the presence of He-ash (4%) and Be ions (2%) demonstrates the agreement between the present data and the ADAS database within 10%. Finally, the maximum deviation of 15% is found only for beam-emission data at the electron density of 1×1012-2×1012cm-3, which is significantly below the ITER density of 1014cm-3.

  5. Technology, Active Learning, and Retention in General Education Mathematics

    Science.gov (United States)

    Levi, Inessa; Chahine, Iman; Garrett, Lauretta; Wang, Haifeng

    2016-01-01

    Difficulties in general education mathematics courses may be attributed to many factors, primarily low proficiency in symbol manipulation, a perception that mathematics is an area which eludes mastery, a lack of engagement and effective practice. Educational technology can be a powerful aid in overcoming these factors. This work describes the…

  6. Situation awareness of active distribution network: roadmap, technologies, and bottlenecks

    DEFF Research Database (Denmark)

    Lin, Jin; Wan, Can; Song, Yonghua

    2016-01-01

    that operators are aware of operation states and potential risks. Current solutions in distribution supervisory control and data acquisition (DSCADA) as well as the distribution automation system (DAS) generally are not able to meet the technology requirements of SA. In this paper, the authors’ participation...

  7. Key Technologies in Mobile Visual Search and MPEG Standardization Activities

    Institute of Scientific and Technical Information of China (English)

    Ling- Yu Duan; Jie Chen; Chunyu Wang; Rongrong Ji; Tiejun Huang; Wen Gao

    2012-01-01

    Visual search has been a long-standing problem in applications such as location recognition and product search. Much research has been done on image representation, matching, indexing, and retrieval. Key component technologies for visual search have been developed, and numerous real-world applications are emerging. To ensure application interoperability, the Moving Picture Experts Group (MPEG) has begun standardizing visuaJ search technologies and is developing the compact descriptors for visua) search (CDVS) standard. MPEG seeks to develop a collaborative platform for evaluating existing visual search technologies. Peking University has participated in this standardization since the 94th MPEG meeting, and significant progress has been made with the various proposals. A test model (TM) has been selected to determine the basic pipeline and key components of visual search. However, the first-version TM has high computational complexity and imperfect retrieval and matching. Core experiments have therefore been set up to improve TM. In this article, we summarize key technologies for visual search and report the progress of MPEG CDVS. We discuss Peking University' s efforts in CDVS and also discuss unresolved issues.

  8. Neurounina-1, a novel compound that increases Na+/Ca2+ exchanger activity, effectively protects against stroke damage.

    Science.gov (United States)

    Molinaro, Pasquale; Cantile, Maria; Cuomo, Ornella; Secondo, Agnese; Pannaccione, Anna; Ambrosino, Paolo; Pignataro, Giuseppe; Fiorino, Ferdinando; Severino, Beatrice; Gatta, Elena; Sisalli, Maria José; Milanese, Marco; Scorziello, Antonella; Bonanno, Giambattista; Robello, Mauro; Santagada, Vincenzo; Caliendo, Giuseppe; Di Renzo, Gianfranco; Annunziato, Lucio

    2013-01-01

    Previous studies have demonstrated that the knockdown or knockout of the three Na(+)/Ca(2+) exchanger (NCX) isoforms, NCX1, NCX2, and NCX3, worsens ischemic brain damage. This suggests that the activation of these antiporters exerts a neuroprotective action against stroke damage. However, drugs able to increase the activity of NCXs are not yet available. We have here succeeded in synthesizing a new compound, named neurounina-1 (7-nitro-5-phenyl-1-(pyrrolidin-1-ylmethyl)-1H-benzo[e][1,4]diazepin-2(3H)-one), provided with an high lipophilicity index and able to increase NCX activity. Ca(2+) radiotracer, Fura-2 microfluorimetry, and patch-clamp techniques revealed that neurounina-1 stimulated NCX1 and NCX2 activities with an EC(50) in the picomolar to low nanomolar range, whereas it did not affect NCX3 activity. Furthermore, by using chimera strategy and site-directed mutagenesis, three specific molecular determinants of NCX1 responsible for neurounina-1 activity were identified in the α-repeats. Interestingly, NCX3 became responsive to neurounina-1 when both α-repeats were replaced with the corresponding regions of NCX1. In vitro studies showed that 10 nM neurounina-1 reduced cell death of primary cortical neurons exposed to oxygen-glucose deprivation followed by reoxygenation. Moreover, in vitro, neurounina-1 also reduced γ-aminobutyric acid (GABA) release, enhanced GABA(A) currents, and inhibited both glutamate release and N-methyl-d-aspartate receptors. More important, neurounina-1 proved to have a wide therapeutic window in vivo. Indeed, when administered at doses of 0.003 to 30 μg/kg i.p., it was able to reduce the infarct volume of mice subjected to transient middle cerebral artery occlusion even up to 3 to 5 hours after stroke onset. Collectively, the present study shows that neurounina-1 exerts a remarkable neuroprotective effect during stroke and increases NCX1 and NCX2 activities.

  9. Thermoregulation and heat exchange in a nonuniform thermal environment during simulated extended EVA. Extravehicular activities

    Science.gov (United States)

    Koscheyev, V. S.; Leon, G. R.; Hubel, A.; Nelson, E. D.; Tranchida, D.

    2000-01-01

    BACKGROUND: Nonuniform heating and cooling of the body, a possibility during extended duration extravehicular activities (EVA), was studied by means of a specially designed water circulating garment that independently heated or cooled the right and left sides of the body. The purpose was to assess whether there was a generalized reaction on the finger in extreme contradictory temperatures on the body surface, as a potential heat status controller. METHOD: Eight subjects, six men and two women, were studied while wearing a sagittally divided experimental garment with hands exposed in the following conditions: Stage 1 baseline--total body garment inlet water temperature at 33 degrees C; Stage 2--left side inlet water temperature heated to 45 degrees C; right side cooled to 8 degrees C; Stage 3--left side inlet water temperature cooled to 8 degrees C, right side heated to 45 degrees C. RESULTS: Temperatures on each side of the body surface as well as ear canal temperature (Tec) showed statistically significant Stage x Side interactions, demonstrating responsiveness to the thermal manipulations. Right and left finger temperatures (Tfing) were not significantly different across stages; their dynamic across time was similar. Rectal temperature (Tre) was not reactive to prevailing cold on the body surface, and therefore not informative. Subjective perception of heat and cold on the left and right sides of the body was consistent with actual temperature manipulations. CONCLUSIONS: Tec and Tre estimates of internal temperature do not provide accurate data for evaluating overall thermal status in nonuniform thermal conditions on the body surface. The use of Tfing has significant potential in providing more accurate information on thermal status and as a feedback method for more precise thermal regulation of the astronaut within the EVA space suit.

  10. Low temperature activation of methane over a zinc-exchanged heteropolyacid as an entry to its selective oxidation to methanol and acetic acid

    KAUST Repository

    Patil, Umesh

    2014-01-01

    A Zn-exchanged heteropolyacid supported onto silica (Zn-HPW/SiO2) activates methane at 25 °C into Zn-methyl. At higher temperatures and with CH4/O2 or CH4/CO2, it gives methanol and acetic acid respectively. This journal is

  11. An innovative treatment concept for future drinking water production: fluidized ion exchange – ultrafiltration – nanofiltration – granular activated carbon filtration

    NARCIS (Netherlands)

    Li, S.; Heijman, S.G.J.; Verberk, J.Q.J.C.; Van Dijk, J.C.

    2009-01-01

    A new treatment concept for drinking water production from surface water has been investigated on a pilot scale. The treatment concept consists of fluidized ion exchange (FIEX), ultrafiltration (UF), nanofiltration (NF), and granular activated carbon filtration (GAC). The FIEX process removed calciu

  12. Sites involved in intra- and interdomain allostery associated with the activation of factor VIIa pinpointed by hydrogen-deuterium exchange and electron transfer dissociation mass spectrometry

    DEFF Research Database (Denmark)

    Song, Hongjian; Olsen, Ole H; Persson, Egon;

    2014-01-01

    enhancement remain elusive. Here we have applied hydrogen/deuterium exchange mass spectrometry coupled to electron transfer dissociation to pinpoint individual residues in the heavy chain of FVIIa whose conformation and/or local interaction pattern changes when the enzyme transitions to the active form...

  13. Phosphorylation- and nucleotide-binding-induced changes to the stability and hydrogen exchange patterns of JNK1ß1 provide insight into its mechanisms of activation

    CSIR Research Space (South Africa)

    Owen, GR

    2014-10-01

    Full Text Available –deuterium exchange (HX) mass spectrometry were used to investigate the changes to the stability and conformation/conformational dynamics of JNK1ß1 induced by phosphorylative activation. Equivalent studies were also employed to determine the effects of nucleotide...

  14. Operation of the power information center: Performance of secretariat functions and information exchange activities in the advanced power field of the interagency advanced power group

    Science.gov (United States)

    1983-01-01

    Highlights of activities conducted during the reporting period to facilitate the exchange of technical information among scientists and engineers both within the federal government and within industry are cited. Interagency Advanced Power Group meetings and special efforts, project briefs, and organization development are considered.

  15. Defective jejunal and colonic salt absorption and alteredNa +/H+ exchanger 3 (NHE3) activity in NHE regulatory factor 1 (NHERF1) adaptor protein-deficient mice

    NARCIS (Netherlands)

    N. Broere (Nellie); M. Chen (Min); A. Cinar (Ayhan); A.K. Singh (Arbind); J. Hillesheim (Jutta); B. Riederer (Beat Michel); M. Lunnemann; I. Rottinghaus (Ingrid); A. Krabbenhöft (Anja); R. Engelhardt (Regina); B. Rausch; E.J. Weinman (Edward); M. Donowitz (Mark); A. Hubbard; O. Kocher (Olivier); H.R. de Jonge (Hugo); B.M. Hogema (Boris); U. Seidler (Ursula)

    2009-01-01

    textabstractWe investigated the role of the Na+/H+ exchanger regulatory factor 1 (NHERF1) on intestinal salt and water absorption, brush border membrane (BBM) morphology, and on the NHE3 mRNA expression, protein abundance, and transport activity in the murine intestine. NHERF1-deficient mice display

  16. Iodine adsorption on ion-exchange resins and activated carbons: batch testing

    Energy Technology Data Exchange (ETDEWEB)

    Parker, Kent E.; Golovich, Elizabeth C.; Wellman, Dawn M.

    2014-09-30

    Iodine sorption onto seven resins and six carbon materials was evaluated using water from well 299-W19-36 on the Hanford Site. These materials were tested using a range of solution-to-solid ratios. The test results are as follows. The efficacy of the resin and granular activated carbon materials was less than predicted based on manufacturers’ performance data. It is hypothesized that this is due to the differences in speciation previously determined for Hanford groundwater. The sorption of iodine is affected by the iodine species in the source water. Iodine loading on resins using source water ranged from 1.47 to 1.70 µg/g with the corresponding Kd values from 189.9 to 227.0 mL/g. The sorption values when the iodine is converted to iodide ranged from 2.75 to 5.90 µg/g with the corresponding Kd values from 536.3 to 2979.6 mL/g. It is recommended that methods to convert iodine to iodide be investigated in fiscal year (FY) 2015. The chemicals used to convert iodine to iodate adversely affected the sorption of iodine onto the carbon materials. Using as-received source water, loading and Kd values ranged from 1.47 to 1.70 µg/g and 189.8 to 226.3 mL/g respectively. After treatment, loading and Kd values could not be calculated because there was little change between the initial and final iodine concentration. It is recommended the cause of the decrease in iodine sorption be investigated in FY15. In direct support of CH2M HILL Plateau Remediation Company, Pacific Northwest National Laboratory has evaluated samples from within the 200W pump and treat bioreactors. As part of this analysis, pictures taken within the bioreactor reveal a precipitate that, based on physical properties and known aqueous chemistry, is hypothesized to be iron pyrite or chalcopyrite, which could affect iodine adsorption. It is recommended these materials be tested at different solution-to-solid ratios in FY15 to determine their effect on iodine

  17. Fiscal 2000 survey of geological structures overseas. Exchange of engineers with Indonesia (Coal mining technology); 2000 nendo kaigai chishitsu kozo nado chosa hokokusho. Gijutsusha koryu jigyo (tanko gijutsu bun'ya) Indonesia

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    Indonesia rich in coal resources consumed 70-million tons of coal in 1999, which covered 17% of its total energy demand. It is estimated that as much as 120-million tons will be produced in 2005, and it is expected that underground mining will increase. Under such circumstances, Indonesia strongly desires that Japan's underground mining technologies be transferred to Indonesia. For the transfer of technologies especially involving production control and management out of Japan's underground mining technologies, Japan dispatched engineers to Indonesia under a mining engineer exchange project, and received and trained Indonesian engineers. Under the engineer exchange project, five engineers were dispatched to Indonesia and gave lectures and on-site training in the period July 9 through August 5, 2000. Japan received seven engineers, who were given lectures and training at the Ikeshima mining field of Matsushima Coal Mining Company in the period November 12 through December 12, 2000. (NEDO)

  18. Dissecting the effect of RNA aptamer binding on the dynamics of plasminogen activator inhibitor 1 using hydrogen/deuterium exchange mass spectrometry

    DEFF Research Database (Denmark)

    Trelle, Morten B; Dupont, Daniel Miotto; Madsen, Jeppe Buur

    2014-01-01

    , about their effects on protein conformation and dynamics. We have employed hydrogen/deuterium exchange (HDX) mass spectrometry to study the effect of RNA aptamers on the structural flexibility of the serpin plasminogen activator inhibitor-1 (PAI-1). The aptamers have characteristic effects...... of the aptamers to PAI-1 is associated with substantial and widespread protection against deuterium uptake in PAI-1. The aptamers induce protection against exchange with the solvent both in the protein-aptamer interface as well as in other specific areas. Interestingly, the aptamers induce substantial protection...

  19. Technical engineers exchange project (coal mine technology field). Training in China; Gijutsusha koryu jigyo (tanko gijutsu bun`ya). Chugoku no kenshu ni tsuite

    Energy Technology Data Exchange (ETDEWEB)

    Adachi, T. [Japan Coal Energy Center, Tokyo (Japan)

    1998-07-01

    The paper described JCOAL`s project on the exchange of technical coal engineers of China. In the project on sending of engineers to China in the first term, coal mine engineers of Japan (Taiheiyo Coal Mine, Kushiro Works, Training Center) were sent to the Daitun coal-thermal power plant, Peixuan city, Jiangsu province, in September, 1997 to introduce the production control technology in Japan. They contributed to the heightening of productivity in coal mines in China. Eighteen Chinese participated in the training. Mechanization has been comparatively well in progress, and it was 83% in coal mining and 91% in drilling. The kind of coal is mostly a raw material coal. The stuff members are 30,000, and expert engineers are 4,200. The plant has an output of 130,000 kWh, owns its railroad, is run on the general multiple management, and is largely developing. The project on sending of engineers to China in the last term was carried out in February 1998 for tracing/confirming how the results of the training conducted in September are made the most of and if or not there is something bad and for obtaining the detailed data. A certain degree of promotion and effects were able to be confirmed. A project on training of the head, sub-head, etc. who were invited to Japan to lean production/management control was also carried out in November and December 1997. 1 tab.

  20. The Search for signals of technological activities in the galaxy

    CERN Document Server

    Lemarchand, Guillermo A

    2010-01-01

    In this article an analysis of the fundamentals used to search for extraterrestrial artificial signals in the galaxy, which have been developing for more than five decades, is presented. It is shown that the key factor for the success of these research projects is given by the technological civilizations lifetimes. Assuming the Principle of Mediocrity, estimations are made to determine the minimum number of civilizations that may co-exist in the galaxy and the probability of detecting a signal from them.

  1. The Search for signals of technological activities in the galaxy

    OpenAIRE

    Lemarchand, Guillermo A.

    2010-01-01

    In this article an analysis of the fundamentals used to search for extraterrestrial artificial signals in the galaxy, which have been developing for more than five decades, is presented. It is shown that the key factor for the success of these research projects is given by the technological civilizations lifetimes. Assuming the Principle of Mediocrity, estimations are made to determine the minimum number of civilizations that may co-exist in the galaxy and the probability of detecting a signa...

  2. Overview on R and D and design activities for the ITER core charge exchange spectroscopy diagnostic system

    Energy Technology Data Exchange (ETDEWEB)

    Biel, W., E-mail: w.biel@fz-juelich.de [Institut fuer Energieforschung - Plasmaphysik, Forschungszentrum Juelich Gmbh, Association EURATOM-FZJ, member of Trilateral Euregio Cluster, 52425 Juelich (Germany); Baross, T. [KFKI RMKI, EURATOM Association, PO Box 49, H-1521 Budapest (Hungary); Bourauel, P. [Institut fuer Energieforschung - Plasmaphysik, Forschungszentrum Juelich Gmbh, Association EURATOM-FZJ, member of Trilateral Euregio Cluster, 52425 Juelich (Germany); Dunai, D. [KFKI RMKI, EURATOM Association, PO Box 49, H-1521 Budapest (Hungary); Durkut, M. [TNO Science and Industry, Partner in ITER-NL, P.O. Box 155, 2600 AD Delft (Netherlands); Erdei, G. [BME, EURATOM Association, PO Box 91, H-1521 Budapest (Hungary); Hawkes, N. [Association EURATOM/CCFE, OX14 3DB Abingdon (United Kingdom); Hellermann, M. von [FOM-Institute for Plasma Physics Rijnhuizen, Association EURATOM-FOM, partner in the Trilateral Euregio Cluster and ITER-NL, P.O. Box 1207, 3430 BE Nieuwegein (Netherlands); Hogenbirk, A. [Nuclear Research and Consultancy Group V.o.F., Petten (Netherlands); Jaspers, R. [Department of Applied Physics, Eindhoven University of Technology (Netherlands); Kiss, G. [Institut fuer Energieforschung - Plasmaphysik, Forschungszentrum Juelich Gmbh, Association EURATOM-FZJ, member of Trilateral Euregio Cluster, 52425 Juelich (Germany); Klinkhamer, F. [TNO Science and Industry, Partner in ITER-NL, P.O. Box 155, 2600 AD Delft (Netherlands); Koning, J.F. [FOM-Institute for Plasma Physics Rijnhuizen, Association EURATOM-FOM, partner in the Trilateral Euregio Cluster and ITER-NL, P.O. Box 1207, 3430 BE Nieuwegein (Netherlands); Kotov, V.; Krasikov, Y.; Krimmer, A. [Institut fuer Energieforschung - Plasmaphysik, Forschungszentrum Juelich Gmbh, Association EURATOM-FZJ, member of Trilateral Euregio Cluster, 52425 Juelich (Germany)

    2011-10-15

    The ITER core charge exchange recombination spectroscopy (core CXRS) diagnostic system is designed to provide experimental access to various measurement quantities in the ITER core plasma such as ion densities, temperatures and velocities. The implementation of the approved CXRS diagnostic principle on ITER faces significant challenges: First, a comparatively low CXRS signal intensity is expected, together with a high noise level due to bremsstrahlung, while the requested measurement accuracy and stability for the core CXRS system go far beyond the level commonly achieved in present-day fusion experiments. Second, the lifetime of the first mirror surface is limited due to either erosion by fast particle bombardment or deposition of impurities. Finally, the hostile technical environment on ITER imposes challenging boundary conditions for the diagnostic integration and operation, including high neutron loads, electro-magnetic loads, seismic events and a limited access for maintenance. A brief overview on the R and D and design activities for the core CXRS system is presented here, while the details are described in parallel papers.

  3. Catalytic activity of thiacalix[4]arenetetrasulfonate metal complexes on modified anion-exchangers for ascorbic acid oxidation.

    Science.gov (United States)

    Odo, Junichi; Hirashima, Tomomi; Hayashida, Tomoko; Miyauchi, Asuka; Minemoto, Mami; Iuchi, Masato; Inoguchi, Masahiko

    2013-01-01

    The catalysis of ascorbic acid (AsA) oxidation by anion-exchangers modified with metal complexes of thiacalix[4]arenetetrasulfonate (Me-TCAS[4]A-500, Me=Mn(3+), Fe(3+), Co(3+), Ce(4+), Cu(2+), Zn(2+), Ni(2+), and H2) were investigated. Me-TCAS[4]A-500 (Me=Mn(3+), Fe(3+), Ce(4+), and Cu(2+)) all exhibited the ability to catalyze the oxidative reaction of AsA to dehydroascorbic acid. However, in the presence of high concentrations of AsA, only Cu(2+)-TCAS[4]A-500 was capable of complete oxidation of the acid. Moreover, after six repeat uses, Cu(2+)-TCAS[4]A-500 maintained high and relatively constant catalytic activity. Prior treatment of glucose solutions with Cu(2+)-TCAS[4]A-500, even in the presence of high AsA concentrations, enabled the satisfactory determination of glucose without interference by AsA. Cu(2+)-TCAS[4]A-500 will therefore be applicable as an artificial substitute for ascorbate oxidase, and may be useful as a means to eliminate AsA interference during the analysis of vital compounds such as glucose and uric acid.

  4. An innovative treatment concept for future drinking water production: fluidized ion exchange-ultrafiltration-nanofiltration-granular activated carbon filtration

    Directory of Open Access Journals (Sweden)

    J. C. van Dijk

    2009-01-01

    Full Text Available A new treatment concept for drinking water production from surface water has been investigated on a pilot scale. The treatment concept consists of fluidized ion exchange (FIEX, ultrafiltration (UF, nanofiltration (NF, and granular activated carbon filtration (GAC. The FIEX process removed calcium and other divalent cations; the UF membrane removed particles and micro-organisms; and the NF membrane and GAC removed natural organic matter (NOM and micro-pollutants. This study focused on the prevention of fouling of the UF and scaling of the NF and investigated the overall removal of micro-pollutants by the treatment concept. The results of the experiments showed that in 14 days of continuous operation at a flux of 65 l/h. m2 the UF performance was stable with the FIEX pre-treated feed water without the aid of a coagulant. The scaling of the NF was also not observed even at 97% recovery. Different micro-pollutants were spiked in the NF feed water and their concentrations in the effluent of NF and GAC were measured. The combination of NF and GAC removed most of the micro-pollutants successfully, except for the very polar substances with a molecular weight lower than 100 Daltons.

  5. Idaho Nuclear Technology and Engineering Center Low-Activity Waste Process Technology Program FY-2000 Status Report

    Energy Technology Data Exchange (ETDEWEB)

    Herbst, Alan Keith; Mc Cray, John Alan; Kirkham, Robert John; Pao, Jenn Hai; Argyle, Mark Don; Lauerhass, Lance; Bendixsen, Carl Lee; Hinckley, Steve Harold

    2000-11-01

    The Low-Activity Waste Process Technology Program anticipated that grouting will be used for disposal of low-level and transuranic wastes generated at the Idaho Nuclear Technology Engineering Center (INTEC). During fiscal year 2000, grout formulations were studied for transuranic waste derived from INTEC liquid sodium-bearing waste and for projected newly generated low-level liquid waste. Additional studies were completed using silica gel and other absorbents to solidify sodium-bearing wastes. A feasibility study and conceptual design were completed for the construction of a grout pilot plant for simulated wastes and demonstration facility for actual wastes.

  6. Idaho Nuclear Technology and Engineering Center Low-Activity Waste Process Technology Program FY-2000 Status Report

    Energy Technology Data Exchange (ETDEWEB)

    Herbst, A.K.; McCray, J.A.; Kirkham, R.J.; Pao, J.; Argyle, M.D.; Lauerhass, L.; Bendixsen, C.L.; Hinckley, S.H.

    2000-10-31

    The Low-Activity Waste Process Technology Program anticipated that grouting will be used for disposal of low-level and transuranic wastes generated at the Idaho Nuclear Technology Engineering Center (INTEC). During fiscal year 2000, grout formulations were studied for transuranic waste derived from INTEC liquid sodium-bearing waste and for projected newly generated low-level liquid waste. Additional studies were completed using silica gel and other absorbents to solidify sodium-bearing wastes. A feasibility study and conceptual design were completed for the construction of a grout pilot plant for simulated wastes and demonstration facility for actual wastes.

  7. Networking activities in technology-based entrepreneurial teams

    DEFF Research Database (Denmark)

    Neergaard, Helle

    2005-01-01

    Based on social network theoy, this article investigates the distribution of networking roles and responsibilities in entrepreneurial founding teams. Its focus is on the team as a collection of individuals, thus allowing the research to address differences in networking patterns. It identifies six...... central networking activities and shows that not all founding team members are equally active 'networkers'. The analyses show that team members prioritize different networking activities and that one member in particular has extensive networking activities whereas other memebrs of the team are more...

  8. Bandwidth-limited active suspension controller for an off-road vehicle based on co-simulation technology

    Institute of Scientific and Technical Information of China (English)

    Jinzhi FENG; Songlin ZHENG; Fan YU

    2008-01-01

    This paper presents the design process of a controller for bandwidth-limited active hydro-pneumatic suspension employed by an off-road vehicle based on co-simulation technology. First, a detailed multi-body dynamic model of the vehicle is established by using the ADAMS/View software package, which is followed by validation using a vehicle field test. Second, a combined PID and fuzzy controller is designed for the bandwidth-limited active suspension system and then programmed by means of S-functions in Matlab/Simulink, to which a data exchange interface with ADAMS/View is also defined. Third, the proposed control algorithm is implemented on the multi-body dynamic vehicle model to enable the co-simulation to run repeatedly until a more practical controller is achieved. In the end, the proposed active suspension system is compared with a conven-tional passive system. Simulation results show that the proposed active suspension system considerably improves both the ride and handling performance of the vehicle and therefore increases the maximum travel-ing speeds even on rough roads.

  9. The rapid and direct determination of ATPase activity by ion exchange chromatography and the application to the activity of heat shock protein-90.

    Science.gov (United States)

    Bartolini, Manuela; Wainer, Irving W; Bertucci, Carlo; Andrisano, Vincenza

    2013-01-25

    Adenosine nucleotides are involved as substrates or co-factors in several biochemical reactions, catalyzed by enzymes, which modulate energy production, signal transduction and cell proliferation. We here report the development and optimization of an ion exchange liquid chromatography (LC) method for the determination of ATP, ADP and AMP. This method is specifically aimed at the determination of the ATP-ase activity of human heat shock protein 90 (Hsp90), a molecular chaperone that has emerged as target enzyme in cancer therapy. Separation of the three nucleotides was achieved in a 15-min run by using a disk shaped monolithic ethylene diamine stationary phase of small dimensions (2mm×6mm i.d.), under a three-solvent gradient elution mode and UV detection at 256nm. The described direct LC method resulted highly specific as a consequence of the baseline separation of the three adenosine nucleotides and could be applied to the determination of the enzymatic activity of ADP/ATP generating or consuming enzymes (such as kinases). Furthermore, comparison of the LOD and LOQ values of the LC method with those obtained with the malachite green assay, which is one of the most used indirect screening methodologies for ATP-ase activity, showed that the LC method has a similar range of application without presenting the drawbacks related to contamination by inorganic phosphate ions and glycerol, which are present in Hsp90 commercial samples.

  10. Aberration Corrected Emittance Exchange

    CERN Document Server

    Nanni, Emilio A

    2015-01-01

    Full exploitation of emittance exchange (EEX) requires aberration-free performance of a complex imaging system including active radio-frequency (RF) elements which can add temporal distortions. We investigate the performance of an EEX line where the exchange occurs between two dimensions with normalized emittances which differ by orders of magnitude. The transverse emittance is exchanged into the longitudinal dimension using a double dog-leg emittance exchange setup with a 5 cell RF deflector cavity. Aberration correction is performed on the four most dominant aberrations. These include temporal aberrations that are corrected with higher order magnetic optical elements located where longitudinal and transverse emittance are coupled. We demonstrate aberration-free performance of emittances differing by 4 orders of magnitude, i.e. an initial transverse emittance of $\\epsilon_x=1$ pm-rad is exchanged with a longitudinal emittance of $\\epsilon_z=10$ nm-rad.

  11. Increased Na+/Ca2+ exchanger activity promotes resistance to excitotoxicity in cortical neurons of the ground squirrel (a Hibernator.

    Directory of Open Access Journals (Sweden)

    Juan-Juan Zhao

    Full Text Available Ground squirrel, a hibernating mammalian species, is more resistant to ischemic brain stress than rat. Gaining insight into the adaptive mechanisms of ground squirrels may help us design treatment strategies to reduce brain damage in patients suffering ischemic stroke. To understand the anti-stress mechanisms in ground squirrel neurons, we studied glutamate toxicity in primary cultured neurons of the Daurian ground squirrel (Spermophilus dauricus. At the neuronal level, for the first time, we found that ground squirrel was more resistant to glutamate excitotoxicity than rat. Mechanistically, ground squirrel neurons displayed a similar calcium influx to the rat neurons in response to glutamate or N-methyl-D-aspartate (NMDA perfusion. However, the rate of calcium removal in ground squirrel neurons was markedly faster than in rat neurons. This allows ground squirrel neurons to maintain lower level of intracellular calcium concentration ([Ca2+]i upon glutamate insult. Moreover, we found that Na+/Ca2+ exchanger (NCX activity was higher in ground squirrel neurons than in rat neurons. We also proved that overexpression of ground squirrel NCX2, rather than NCX1 or NCX3, in rat neurons promoted neuron survival against glutamate toxicity. Taken together, our results indicate that ground squirrel neurons are better at maintaining calcium homeostasis than rat neurons and this is likely achieved through the activity of ground squirrel NCX2. Our findings not only reveal an adaptive mechanism of mammalian hibernators at the cellular level, but also suggest that NCX2 of ground squirrel may have therapeutic value for suppressing brain ischemic damage.

  12. Macula densa Na(+)/H(+) exchange activities mediated by apical NHE2 and basolateral NHE4 isoforms.

    Science.gov (United States)

    Peti-Peterdi, J; Chambrey, R; Bebok, Z; Biemesderfer, D; St John, P L; Abrahamson, D R; Warnock, D G; Bell, P D

    2000-03-01

    Functional and immunohistochemical studies were performed to localize and identify Na(+)/H(+) exchanger (NHE) isoforms in macula densa cells. By using the isolated perfused thick ascending limb with attached glomerulus preparation dissected from rabbit kidney, intracellular pH (pH(i)) was measured with fluorescence microscopy by using 2',7'-bis-(2-carboxyethyl)-5-(and -6) carboxyfluorescein. NHE activity was assayed by measuring the initial rate of Na(+)-dependent pH(i) recovery from an acid load imposed by prior lumen and bath Na(+) removal. Removal of Na(+) from the bath resulted in a significant, DIDS-insensitive, ethylisopropyl amiloride (EIPA)-inhibitable decrease in pH(i). This basolateral transporter showed very low affinity for EIPA and Hoechst 694 (IC(50) = 9.0 and 247 microM, respectively, consistent with NHE4). The recently reported apical NHE was more sensitive to inhibition by these drugs (IC(50) = 0.86 and 7.6 microM, respectively, consistent with NHE2). Increasing osmolality, a known activator of NHE4, greatly stimulated basolateral NHE. Immunohistochemical studies using antibodies against NHE1-4 peptides demonstrated expression of NHE2 along the apical and NHE4 along the basolateral, membrane, whereas NHE1 and NHE3 were not detected. These results suggest that macula densa cells functionally and immunologically express NHE2 at the apical membrane and NHE4 at the basolateral membrane. These two isoforms likely participate in Na(+) transport, pH(i), and cell volume regulation and may be involved in tubuloglomerular feedback signaling by these cells.

  13. Reduced junctional Na+/Ca2+-exchanger activity contributes to sarcoplasmic reticulum Ca2+ leak in junctophilin-2-deficient mice

    Science.gov (United States)

    Wang, Wei; Landstrom, Andrew P.; Wang, Qiongling; Munro, Michelle L.; Beavers, David; Ackerman, Michael J.; Soeller, Christian

    2014-01-01

    Expression silencing of junctophilin-2 (JPH2) in mouse heart leads to ryanodine receptor type 2 (RyR2)-mediated sarcoplasmic reticulum (SR) Ca2+ leak and rapid development of heart failure. The mechanism and physiological significance of JPH2 in regulating RyR2-mediated SR Ca2+ leak remains elusive. We sought to elucidate the role of JPH2 in regulating RyR2-mediated SR Ca2+ release in the setting of cardiac failure. Cardiac myocytes isolated from tamoxifen-inducible conditional knockdown mice of JPH2 (MCM-shJPH2) were subjected to confocal Ca2+ imaging. MCM-shJPH2 cardiomyocytes exhibited an increased spark frequency width with altered spark morphology, which caused increased SR Ca2+ leakage. Single channel studies identified an increased RyR2 open probability in MCM-shJPH2 mice. The increase in spark frequency and width was observed only in MCM-shJPH2 and not found in mice with increased RyR2 open probability with native JPH2 expression. Na+/Ca2+-exchanger (NCX) activity was reduced by 50% in MCM-shJPH2 with no detectable change in NCX expression. Additionally, 50% inhibition of NCX through Cd2+ administration alone was sufficient to increase spark width in myocytes obtained from wild-type mice. Additionally, superresolution analysis of RyR2 and NCX colocalization showed a reduced overlap between RyR2 and NCX in MCM-shJPH2 mice. In conclusion, decreased JPH2 expression causes increased SR Ca2+ leakage by directly increasing open probability of RyR2 and by indirectly reducing junctional NCX activity through increased dyadic cleft Ca2+. This demonstrates two novel and independent cellular mechanisms by which JPH2 regulates RyR2-mediated SR Ca2+ leak and heart failure development. PMID:25193470

  14. Increased Na+/Ca2+ Exchanger Activity Promotes Resistance to Excitotoxicity in Cortical Neurons of the Ground Squirrel (a Hibernator)

    Science.gov (United States)

    Zhao, Juan-Juan; Gao, Shan; Jing, Jun-Zhan; Zhu, Ming-Yue; Zhou, Chen; Chai, Zhen

    2014-01-01

    Ground squirrel, a hibernating mammalian species, is more resistant to ischemic brain stress than rat. Gaining insight into the adaptive mechanisms of ground squirrels may help us design treatment strategies to reduce brain damage in patients suffering ischemic stroke. To understand the anti-stress mechanisms in ground squirrel neurons, we studied glutamate toxicity in primary cultured neurons of the Daurian ground squirrel (Spermophilus dauricus). At the neuronal level, for the first time, we found that ground squirrel was more resistant to glutamate excitotoxicity than rat. Mechanistically, ground squirrel neurons displayed a similar calcium influx to the rat neurons in response to glutamate or N-methyl-D-aspartate (NMDA) perfusion. However, the rate of calcium removal in ground squirrel neurons was markedly faster than in rat neurons. This allows ground squirrel neurons to maintain lower level of intracellular calcium concentration ([Ca2+]i) upon glutamate insult. Moreover, we found that Na+/Ca2+ exchanger (NCX) activity was higher in ground squirrel neurons than in rat neurons. We also proved that overexpression of ground squirrel NCX2, rather than NCX1 or NCX3, in rat neurons promoted neuron survival against glutamate toxicity. Taken together, our results indicate that ground squirrel neurons are better at maintaining calcium homeostasis than rat neurons and this is likely achieved through the activity of ground squirrel NCX2. Our findings not only reveal an adaptive mechanism of mammalian hibernators at the cellular level, but also suggest that NCX2 of ground squirrel may have therapeutic value for suppressing brain ischemic damage. PMID:25415196

  15. International exchange project for the engineer exchange project (in coal mine technology area) in fiscal 1998. Pre-survey in Europe; 1998 nendo gijutsusha koryu jigyo (tanko gijutsu bun'ya) kokusai koryu jigyo. Jizen chosa (Oshu)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    This survey in Europe surveyed the current status of the coal industry, supporting directions and policies of governments on the coal industry, and summarized the information thereof. The survey included movements in policies and activities in transfer of technologies to overseas countries by governments and corporations of different countries, and the current status of the coal technology training project. The survey covered Britain and Germany. The British coal industry is facing a serious difficulty because the electric power industry being the major coal purchaser has changes its sourcing to natural gas. In addition, the open-cut mining which has been considered high in productivity has no further hope of big progress due to regulations in the environmental aspects. However, as a result of having performed positively research and development on production cost reduction, the production efficiency has grown excellently. Using this situation as the base, positive advancement into overseas countries is being carried out. The German coal industry has, in spite of having reduced the production size and the number of coal mines, shifted coal purchasers to electric power generation and steel making areas, and its quality and supply capability stand equivalent to those of imported coals. (NEDO)

  16. English language learning activity using spoken language and intelligent computer-assisted technologies

    OpenAIRE

    2011-01-01

    This paper presents work in progress on language technologies applied to secondary school education. The application presented integrates several state-of-the-art technologies related to spoken language and intelligent computer-assisted language learning. We envision to show that the technology has reached a level of maturity that suggests that the time may be right to use it to second language learning. To achieve this objective, an activity was designed to be tested at several Spanish...

  17. USE OF INFORMATION TECHNOLOGIES IN EDUCATIONAL EXTRACURRICULAR ACTIVITIES IN HIGHER TOURIST INSTITUTIONS

    Directory of Open Access Journals (Sweden)

    Yuliia O. Matviyiv-Lozynska

    2013-04-01

    Full Text Available The article deals with extracurricular educational activities in higher educational establishment of tourism profile with information technologies usage. It is known that extracurricular activities of higher educational establishment has an impact on the professional activities of future specialists in the tourism industry, as is in the process of extracurricular activities students can put into practice the obtained knowledge and skills. The task of teachers is to build a learning process, in particular activities outside classrooms as its component, so that the students were interested in it. In the modern world of tourism prosperity it is very difficult to do without the usage of multimedia technologies (internet, media, etc.

  18. R&D activities of tritium technologies on Broader Approach in Phase 2-2

    Energy Technology Data Exchange (ETDEWEB)

    Isobe, Kanetsugu, E-mail: isobe.kanetsugu@jaea.go.jp; Kawamura, Yoshinori; Iwai, Yasunori; Oyaidzu, Makoto; Nakamura, Hirofumi; Suzuki, Takumi; Yamada, Masayuki; Edao, Yuki; Kurata, Rie; Hayashi, Takumi; Yamanishi, Toshihiko

    2015-10-15

    Highlights: • R&D activities of tritium technology on BA were introduced. • Representative results in each task were explained. • Future plan of this activity was introduced. - Abstract: Activities on Broader Approach (BA) were started in 2007. In Phase 2-2, many R&Ds, development of tritium accountancy technology, development of basic tritium safety research and tritium durability test, were implemented successfully by JAEA and Japanese Universities. In Phase 2-3, new collaborative study for tritium measurement and new R&D activities for JET ILW are started. R&D activities on BA have continued in Phase 2-3 (2014–2016).

  19. A brief review of JPL's electric propulsion technology activities

    Science.gov (United States)

    Barnett, John W.; Chopra, Ann; Deininger, William D.; Garner, Charles E.; Pivirotto, Thomas J.; Sercel, Joel C.

    1989-01-01

    Near-term objectives and recent technological progress of JPL's electric propulsion program are discussed. Particular attention is given to accomplishments for ion, magnetoplasmadynamic (MPD), electron-cyclotron resonance (ECR), and arcjet thrusters. Xenon ion thruster erosion tests indicate a 15-fold reduction in tantalum baffle erosion when nitrogen is added to the xenon propellant and steady-state cylindrical MPD thruster tests at powers up to 72 kW show distinct self-constricted and diffuse discharge modes. An ECR thruster was operated at up to 7 kW with plasma acceleration at energies up to 7 kW; there was plasma acceleration at energies approaching 100 electron volts.

  20. Working Group 5: Measurements technology and active experiments

    Science.gov (United States)

    Whipple, E.; Barfield, J. N.; Faelthammar, C.-G.; Feynman, J.; Quinn, J. N.; Roberts, W.; Stone, N.; Taylor, W. L.

    1986-01-01

    Technology issues identified by working groups 5 are listed. (1) New instruments are needed to upgrade the ability to measure plasma properties in space. (2) Facilities should be developed for conducting a broad range of plasma experiments in space. (3) The ability to predict plasma weather within magnetospheres should be improved and a capability to modify plasma weather developed. (4) Methods of control of plasma spacecraft and spacecraft plasma interference should be upgraded. (5) The space station laboratory facilities should be designed with attention to problems of flexibility to allow for future growth. These issues are discussed.

  1. Shaping old age: Innovation partnerships, senior centres and billiards tables as active ageing technologies

    DEFF Research Database (Denmark)

    Lassen, Aske Juul

    2017-01-01

    During the past decade active ageing has been positioned as a solution to the problem of global ageing. While the scientific, economic and even moral arguments for pursuing a more active old age has been many, the integration of active ageing in everyday practices face challenges. This chapter...... explores the ways that active ageing policies become part of everyday practices, by proposing the concept of active ageing technologies. Active ageing technologies are material and immaterial condensations of knowledge that form old age in specific ways. Through the cases of an innovation partnership, two...... activity centres and a billiards table, the author explores how active ageing policies are transformed in practice. The chapter draws on an ethnographic study of active ageing conducted at the two activity centres, as well as the author’s participation in the innovation partnership. The author uses...

  2. Activation of exchange protein activated by cAMP in the rat basolateral amygdala impairs reconsolidation of a memory associated with self-administered cocaine.

    Directory of Open Access Journals (Sweden)

    Xun Wan

    Full Text Available The intracellular mechanisms underlying memory reconsolidation critically involve cAMP signaling. These events were originally attributed to PKA activation by cAMP, but the identification of Exchange Protein Activated by cAMP (Epac, as a distinct mediator of cAMP signaling, suggests that cAMP-regulated processes that subserve memory reconsolidation are more complex. Here we investigated how activation of Epac with 8-pCPT-cAMP (8-CPT impacts reconsolidation of a memory that had been associated with cocaine self-administration. Rats were trained to lever press for cocaine on an FR-1 schedule, in which each cocaine delivery was paired with a tone+light cue. Lever pressing was then extinguished in the absence of cue presentations and cocaine delivery. Following the last day of extinction, rats were put in a novel context, in which the conditioned cue was presented to reactivate the cocaine-associated memory. Immediate bilateral infusions of 8-CPT into the basolateral amygdala (BLA following reactivation disrupted subsequent cue-induced reinstatement in a dose-dependent manner, and modestly reduced responding for conditioned reinforcement. When 8-CPT infusions were delayed for 3 hours after the cue reactivation session or were given after a cue extinction session, no effect on cue-induced reinstatement was observed. Co-administration of 8-CPT and the PKA activator 6-Bnz-cAMP (10 nmol/side rescued memory reconsolidation while 6-Bnz alone had no effect, suggesting an antagonizing interaction between the two cAMP signaling substrates. Taken together, these studies suggest that activation of Epac represents a parallel cAMP-dependent pathway that can inhibit reconsolidation of cocaine-cue memories and reduce the ability of the cue to produce reinstatement of cocaine-seeking behavior.

  3. Activation of AMP-activated protein kinase regulates hippocampal neuronal pH by recruiting Na(+)/H(+) exchanger NHE5 to the cell surface.

    Science.gov (United States)

    Jinadasa, Tushare; Szabó, Elöd Z; Numat, Masayuki; Orlowski, John

    2014-07-25

    Strict regulation of intra- and extracellular pH is an important determinant of nervous system function as many voltage-, ligand-, and H(+)-gated cationic channels are exquisitely sensitive to transient fluctuations in pH elicited by neural activity and pathophysiologic events such as hypoxia-ischemia and seizures. Multiple Na(+)/H(+) exchangers (NHEs) are implicated in maintenance of neural pH homeostasis. However, aside from the ubiquitous NHE1 isoform, their relative contributions are poorly understood. NHE5 is of particular interest as it is preferentially expressed in brain relative to other tissues. In hippocampal neurons, NHE5 regulates steady-state cytoplasmic pH, but intriguingly the bulk of the transporter is stored in intracellular vesicles. Here, we show that NHE5 is a direct target for phosphorylation by the AMP-activated protein kinase (AMPK), a key sensor and regulator of cellular energy homeostasis in response to metabolic stresses. In NHE5-transfected non-neuronal cells, activation of AMPK by the AMP mimetic AICAR or by antimycin A, which blocks aerobic respiration and causes acidification, increased cell surface accumulation and activity of NHE5, and elevated intracellular pH. These effects were effectively blocked by the AMPK antagonist compound C, the NHE inhibitor HOE694, and mutation of a predicted AMPK recognition motif in the NHE5 C terminus. This regulatory pathway was also functional in primary hippocampal neurons, where AMPK activation of NHE5 protected the cells from sustained antimycin A-induced acidification. These data reveal a unique role for AMPK and NHE5 in regulating the pH homeostasis of hippocampal neurons during metabolic stress.

  4. Out-of-School Activities Related to Science and Technology

    Directory of Open Access Journals (Sweden)

    Ángel Vázquez Alonso

    2007-05-01

    Full Text Available Artificial and natural environments constitute an extensive educational resource in whose framework the basic experiences that contribute to the development process of human beings occur. These experiences are the source of previous knowledge that students bring to school and that are key for building scientific school learning. This article reports the results of a study that addresses out-of-school experiences related to science and technology, through the application of an inventory list to a sample of students who were in their last year of compulsory education. The results show a relatively low overall frequency of experiences, characterized by some qualitative and quantitative differences according to a few grouping variables such as gender, the choice of an elective science subject, and different scientific topics and disciplines. In spite of its importance for learning, the school curriculum often ignores students’ previous experiences. Finally, we discuss the relevance of these results for developing a more equitable science and technology curriculum, from a perspective of a universal, humanistic science education.

  5. Synthesizing Technology Adoption and Learners' Approaches towards Active Learning in Higher Education

    Science.gov (United States)

    Chan, Kevin; Cheung, George; Wan, Kelvin; Brown, Ian; Luk, Green

    2015-01-01

    In understanding how active and blended learning approaches with learning technologies engagement in undergraduate education, current research models tend to undermine the effect of learners' variations, particularly regarding their styles and approaches to learning, on intention and use of learning technologies. This study contributes to further…

  6. 78 FR 70567 - Nationwide Use of High Frequency and Ultra High Frequency Active SONAR Technology; Final...

    Science.gov (United States)

    2013-11-26

    ...] Nationwide Use of High Frequency and Ultra High Frequency Active SONAR Technology; Final Programmatic... Programmatic Environmental Assessment (PEA) for the Nationwide Use of High Frequency (HF) and Ultra High Frequency (UHF) Sound Navigation and Ranging (SONAR) Technology and Finding of No Significant Impact (FONSI...

  7. Emplotment, Embodiment, Engagement: Narrative Technology in Support of Physical Education, Sport and Physical Activity

    Science.gov (United States)

    Hall, Tony

    2012-01-01

    This paper is based on a keynote lecture delivered at the International Association of Physical Education in Higher Education 2011 Conference, University of Limerick, on the sub theme: "Technologies in Support of Physical Education, Sport, and Physical Activity." The paper outlines and illustrates a framework: narrative technology, which can be…

  8. CAST STONE TECHNOLOGY FOR THE TREATMENT AND IMMOBILIZATION OF LOW-ACTIVITY WASTE

    Energy Technology Data Exchange (ETDEWEB)

    MINWALL HJ

    2011-04-08

    Cast stone technology is being evaluated for potential application in the treatment and immobilization of Hanford low-activity waste. The purpose of this document is to provide background information on cast stone technology. The information provided in the report is mainly based on a pre-conceptual design completed in 2003.

  9. Activity Theory as a Conceptual Framework for Understanding Teacher Approaches to Information and Communication Technologies

    Science.gov (United States)

    Karasavvidis, Ilias

    2009-01-01

    While the issue of teachers' perspectives on the barriers to technology use has received considerable attention, teacher concerns have not been studied in a systematic and holistic way. The present paper examines teacher concerns regarding a proposed technology-based innovation using Activity Theory as a theoretical framework. Fifty-one teachers…

  10. Technology Transfer Activities of NASA/MSFC: Enhancing the Southeast Region's Production Capabilities

    Science.gov (United States)

    Trivoli, George W.

    1998-01-01

    The researcher was charged with the task of developing a simplified model to illustrate the impact of how NASA/MSFC technology transfer activities contribute to shifting outward the Southeast region's and the nation's productive capacity. The report is a background of the impact of technological growth on the nation's production possibility frontier (ppf).

  11. 75 FR 53705 - Science and Technology (S&T) Directorate; Agency Information Collection Activities: Submission...

    Science.gov (United States)

    2010-09-01

    ...-53706] [FR Doc No: 2010-21783] DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2010-0073] Science and Technology (S&T) Directorate; Agency Information Collection Activities: Submission for Review; Information Collection Request for the Department of Homeland Security (DHS) Science and Technology Protected...

  12. 75 FR 53706 - Science and Technology (S&T) Directorate: Agency Information Collection Activities: Submission...

    Science.gov (United States)

    2010-09-01

    ...-53707] [FR Doc No: 2010-21786] DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2010-0072] Science and Technology (S&T) Directorate: Agency Information Collection Activities: Submission for Review; Information Collection Request for the Department of Homeland Security (DHS) Science and Technology TechSolutions...

  13. Utilizing Technology to Improve the Administration of Instructional Physical Activity Programs in Higher Education

    Science.gov (United States)

    Melton, Bridget; Burdette, Trey

    2011-01-01

    The purpose of this article is to provide examples of how technology is being used in one university to increase the organization and effectiveness of instructional physical activity programs (IPAPs). The article outlines ways in which technology can organize materials for students, instructors, and programs. Additionally, the article describes…

  14. The Potential of Using Virtual Reality Technology in Physical Activity Settings

    Science.gov (United States)

    Pasco, Denis

    2013-01-01

    In recent years, virtual reality technology has been successfully used for learning purposes. The purposes of the article are to examine current research on the role of virtual reality in physical activity settings and discuss potential application of using virtual reality technology to enhance learning in physical education. The article starts…

  15. 75 FR 44063 - Designation of the National Science and Technology Council to Coordinate Certain Activities Under...

    Science.gov (United States)

    2010-07-28

    ... Science and Technology Council to Coordinate Certain Activities Under the Arctic Research and Policy Act of 1984 Memorandum for the Director of the Office of Science and Technology Policy By the authority... 107 and 108 of the Act to the Interagency Arctic Research Policy Committee, including...

  16. The Potential of Using Virtual Reality Technology in Physical Activity Settings

    Science.gov (United States)

    Pasco, Denis

    2013-01-01

    In recent years, virtual reality technology has been successfully used for learning purposes. The purposes of the article are to examine current research on the role of virtual reality in physical activity settings and discuss potential application of using virtual reality technology to enhance learning in physical education. The article starts…

  17. Reports on Activities of the IODE Groups of Experts: IODE Group of Experts on Technical Aspects of Data Exchange (GETADE)

    OpenAIRE

    Reed, G.

    2002-01-01

    The IODE Group of Experts on the Technical Aspects of Data Exchange (GETADE) has the following terms of reference (IODE-XV, 1996): (i) Collaborate with IGOSS-CP, IODE GE-MIM and the data management groups of other international bodies and scientific programmes in the development of technical solutions for the management, exchange and easier integration of oceanographic data and information with data from other disciplines. (ii) Collaborate with IODE GE-MIM in the development of a com...

  18. Activating the Zone of Proximal Development of Japanese Language Learners: Language-Exchange Partnerships (LEPs) at an Australian University

    OpenAIRE

    Hiromi Nishioka

    2014-01-01

    This study examines how social interactions in language-exchange partnership sessions can create opportunities for Japanese language learners to use and learn Japanese. The participants in this study were two pairs, consisting of a Japanese native speaker and an Australian studying Japanese at an Australian university. This study, employing Vygotsky’s Zone of Proximal Development and assistance to novices by experts, examined what factors enable participants in language-exchange partnerships ...

  19. Educators Exchange: A Program Evaluation.

    Science.gov (United States)

    Armstrong, William B.

    The Educators Exchange Program (EEP) was established under a training and educational exchange agreement reached by California's San Diego Community College District (SDCCD) and the republic of Mexico. In the program, the District provided a 4-week technological training program to faculty at Centros de Capacitacion Tecnologica Industrial…

  20. Application of active powders at fluidised bed heat treatment technologies

    OpenAIRE

    Babul, T.; Kucharieva, N.

    2014-01-01

    The paper describes the principles and conditions of carrying out of a new type of fluidised bed thermochemical treatment in chemically active powders with different ways of fluidisation. These new fluidised bed thermochemical treatments in chemically active powders are primarily for the formation of surface diffusion layers on parts made of constructional and tool steel. This method can be used for sherardising, alitising, carbonitriding, nitrocarburising, carburising or boronising. Chara...

  1. Methods for Evaluating Learner Activities with New Technologies: Guidelines for the Lab@Future Project

    Science.gov (United States)

    Mwanza-Simwami, Daisy; Engestrom, Yrjo; Amon, Tomaz

    2009-01-01

    The task of evaluating learner activities with new technologies is becoming increasingly complex because traditional evaluation strategies do not adequately consider the unique and often dynamic characteristics of learners and activities carried out. Learner activities are largely driven by motives and relationships that exist in the context in…

  2. Physical activity and situational interest in mobile technology integrated physical education: A preliminary study

    Directory of Open Access Journals (Sweden)

    Xihe Zhu

    2016-06-01

    Full Text Available Background: Mobile technology permeates every aspect of student lives. The question is whether mobile technology integration can produce desirable effects in the gymnasium. Objective: This preliminary study aimed to investigate the effects of mobile technology integration on student situational interest and physical activity fluctuation in physical education lessons.Methods: Sixth grade students (N = 53 were randomly placed into either an experiment group by class that utilized mobile technology-integrated resources (iPad and applications, or a comparison group that did not utilize technology. Both groups received five identical physical education lessons. Student physical activity was tracked with accelerometers, and they completed the Situational Interest Scale at the end of each lesson. The researchers analyzed the data using descriptive statistics, correlation analysis and multivariate analysis of variance (MANOVA with repeated measures. Results: Students in the experiment group reported significantly lower physical activity and situational interest than their counterparts in the comparison group. A group × lesson interaction suggested that student step/min steadily increased throughout the lessons in the experiment group while remaining relative stable in the comparison group. Conclusions: Mobile technologies such as iPad and applications with no direct physical activity prompt had little effect on increasing physical activity or situational interest in the short term. It is important to consider the classroom dynamics to realistically evaluate the constraints and strengths that mobile technology-integrated physical education lessons may pose in a traditional physical education environment.

  3. [Activities of Goddard Earth Sciences and Technology Center, Maryland University

    Science.gov (United States)

    2003-01-01

    The Goddard Space Flight Center (GSFC) is recognized as a world leader in the application of remote sensing and modeling aimed at improving knowledge of the Earth system. The Goddard Earth Sciences Directorate plays a central role in NASA's Earth Observing System and the U.S. Global Change Research Program. Goddard Earth Sciences and Technology (GEST) is organized as a cooperative agreement with the GSFC to promote excellence in the Earth sciences, and is a consortium of universities and corporations (University of Maryland Baltimore County, Howard University, Hampton University, Caelum Research Corporation and Northrop Grumman Corporation). The aim of this new program is to attract and introduce promising students in their first or second year of graduate studies to Oceanography and Earth system science career options through hands-on instrumentation research experiences on coastal processes at NASA's Wallops Flight Facility on the Eastern Shore of Virginia.

  4. Convoy Active Safety Technology - Environmental Understanding and Navigation With Use of Low Cost Sensors

    Science.gov (United States)

    2012-08-01

    program, which was created to design a low cost, optionally manned vehicle ( OMV ) solution for tactical wheeled vehicle (TWV) fleet. This paper will...Active Safety Technology (CAST) development program sought to develop a low cost, optionally manned vehicle ( OMV ) solution. An objective of the CAST...Active Safety Technology (CAST) program, which was created to design a low cost, optionally manned vehicle ( OMV ) solution for tactical wheeled vehicle (TWV

  5. Innovative activity of high-technology companies as assessment and forecasting object

    Directory of Open Access Journals (Sweden)

    A. E. Sklyarov

    2016-01-01

    Full Text Available Innovation activities, as well as innovations, are closely related meanings, and like many others economical definitions, have a broad range of meanings. Main characteristics and attributes of innovation involves new or significantly improved product, that’s being used, or in other words, found its application, and innovative activitiesactivities focused on realization of innovations. In this article, innovations are mainly considered in terms of high-technology production, evidence from Russian space industry. There are 5 basic stages of lifecycle of innovative project in considered industry: initiation, development, realization, expansion, consumption. Practically, third or fourth, or even both of these stages, often missing because there is no need of them. R&D activities, or even further serial production, based on previous developments, is an innovation activity, because these activities are stages of innovative projects lifecycle itself. Then it seems legit, to draw a conclusion, that in terms of high-technology production, company’s primary activity equals innovative activity. Basic characteristics of innovative activity of high-technology companies as assessment and forecasting object involves high level of uncertainty at every stage of projects lifecycle, high dependency on funding level of this activity, and high level and erratic structure of risk. All the above mentioned, means that assessment and forecasting of innovative activity of high-technology companies, needs development of its own methodological tools for each industry.

  6. ECUT: Energy Conversion and Utilization Technologies program - Biocatalysis research activity

    Science.gov (United States)

    Wilcox, R.

    1984-01-01

    The activities of the Biocatalysis Research Activity are organized into the Biocatalysis and Molecular Modeling work elements and a supporting planning and analysis function. In the Biocatalysis work element, progress is made in developing a method for stabilizing genetically engineered traits in microorganisms, refining a technique for monitoring cells that are genetically engineered, and identifying strains of fungi for highly efficient preprocessing of biomass for optimizing the efficiency of bioreactors. In the Molecular Modeling work element, a preliminary model of the behavior of enzymes is developed. A preliminary investigation of the potential for synthesizing enzymes for use in electrochemical processes is completed. Contact with industry and universities is made to define key biocatalysis technical issues and to broaden the range of potential participants in the activity. Analyses are conducted to identify and evaluate potential concepts for future research funding.

  7. Radar activities of the DFVLR Institute for Radio Frequency Technology

    Science.gov (United States)

    Keydel, W.

    1983-01-01

    Aerospace research and the respective applications microwave tasks with respect to remote sensing, position finding and communication are discussed. The radar activities are directed at point targets, area targets and volume targets; they center around signature research for earth and ocean remote sensing, target recognition, reconnaissance and camouflage and imaging and area observation radar techniques (SAR and SLAR). The radar activities cover a frequency range from 1 GHz up to 94 GHz. The radar program is oriented to four possible application levels: ground, air, shuttle orbits and satellite orbits. Ground based studies and measurements, airborne scatterometers and imaging radars, a space shuttle radar, the MRSE, and follow on experiments are considered.

  8. [MEDICAL SOCIAL MODELING TECHNOLOGIES FOR ACTIVE AGING IN KAZAKHSTAN].

    Science.gov (United States)

    Benberin, V V; Akhetov, A A; Tanbaeva, G Z

    2015-01-01

    The article discusses a new model for active ageing in Republic of Kazakhstan with participation the state, population and medical social services. Achieving active longevity will lead to positive trends in the development of human capital of the state, because it enables to use experience and knowledge of senior generation in enhancing the effectiveness of socio-economic transformation in health care. The study was carried out on the base of the Central clinical hospital of the President's affairs administration in Republic of Kazakhstan, with the participation of 147 admitted patients of elderly and senile age.

  9. Radar activities of the DFVLR Institute for Radio Frequency Technology

    Science.gov (United States)

    Keydel, W.

    1983-01-01

    Aerospace research and the respective applications microwave tasks with respect to remote sensing, position finding and communication are discussed. The radar activities are directed at point targets, area targets and volume targets; they center around signature research for earth and ocean remote sensing, target recognition, reconnaissance and camouflage and imaging and area observation radar techniques (SAR and SLAR). The radar activities cover a frequency range from 1 GHz up to 94 GHz. The radar program is oriented to four possible application levels: ground, air, shuttle orbits and satellite orbits. Ground based studies and measurements, airborne scatterometers and imaging radars, a space shuttle radar, the MRSE, and follow on experiments are considered.

  10. Active latent heat storage with a screw heat exchanger - experimental results for heat transfer and concept for high pressure steam

    Science.gov (United States)

    Zipf, Verena; Willert, Daniel; Neuhäuser, Anton

    2016-05-01

    An innovative active latent heat storage concept was invented and developed at Fraunhofer ISE. It uses a screw heat exchanger (SHE) for the phase change during the transport of a phase change material (PCM) from a cold to a hot tank or vice versa. This separates heat transfer and storage tank in comparison to existing concepts. A test rig has been built in order to investigate the heat transfer coefficients of the SHE during melting and crystallization of the PCM. The knowledge of these characteristics is crucial in order to assess the performance of the latent heat storage in a thermal system. The test rig contains a double shafted SHE, which is heated or cooled with thermal oil. The overall heat transfer coefficient U and the convective heat transfer coefficient on the PCM side hPCM both for charging and discharging have been calculated based on the measured data. For charging, the overall heat transfer coefficient in the tested SHE was Uch = 308 W/m2K and for discharging Udis = 210 W/m2K. Based on the values for hPCM the overall heat transfer coefficients for a larger SHE with steam as heat transfer fluid and an optimized geometry were calculated with Uch = 320 W/m2K for charging and Udis = 243 W/m2K for discharging. For pressures as high as p = 100 bar, an SHE concept has been developed, which uses an organic fluid inside the flight of the SHE as working media. With this concept, the SHE can also be deployed for very high pressure, e.g. as storage in solar thermal power plants.

  11. Use of cellphone technology in activity and travel data collection

    CSIR Research Space (South Africa)

    Krygsman, S

    2006-02-01

    Full Text Available Data needs of developing countries, particularly in terms of activity and travel data collection, are explored in this poster. This proof-of-concept study revealed that it is indeed possible to obtain detailed individual travel behaviour data from...

  12. Using Technology to Increase Physical Activity in Health Profession Students

    Directory of Open Access Journals (Sweden)

    Mary Ann Stark

    2016-01-01

    Full Text Available Health profession students may need help establishing and maintaining positive health behaviors when they are in college. This study explored the effectiveness of text messaging as an innovative method for promoting an increase in daily physical activity. A convenience sample (N = 134 was recruited from students at a college of Health and Human Services in Michigan. The participants were randomized into an intervention or control group (n = 67 each. The intervention group received daily affective text messages encouraging more physical activity by taking more steps. The control group received only messages reminding them to report their number of steps. All of the participants received a pedometer, completed a demographics and daily habits questionnaire, and completed the Perceived Stress Scale (PSS. There was no significant difference between the intervention and control groups in their number of daily steps. However, the most inactive participants had a significant increase in steps during the study period. Health profession students’ lifestyle behaviors have consequences, as they become caregivers in our dynamic, demanding health-care system. For those with the greatest need for physical activity, encouraging such activity via text messaging may improve their ability to care for themselves and their clients.

  13. Pro-active Management of Traffic Incidents Using Novel Technologies

    NARCIS (Netherlands)

    Nitsche, P.; Olstam, J.; Taylor, N.; Reinthaler, M.; Ponweiser, W.; Bernhardsson, V.; Mocanu, I.; Uittenbogaard, J.; Dam, E. van

    2016-01-01

    This paper presents the results of the assessment phase of the project PRIMA (Pro-Active Incident Management), where the benefits, costs and risks of novel traffic incident management techniques are investigated. The project targets the enhancement of current state-of-the-art measures for handling

  14. Route activity tracking and management using available technology

    Directory of Open Access Journals (Sweden)

    Sam Yousef Khoury

    2012-01-01

    Full Text Available Small organizations that maintain their own fleet and make their own deliveries are responsible for ensuring their drivers are utilizing the most efficient routes while delivering products to their customers. Furthermore, efficient delivery requires that drivers spend as little time as possible dropping off and picking up products, since these activities are referred to as “non-value added activities,” although they are necessary tasks in the order cycle process. To aid in reducing order cycle times, large organizations that can afford it have employed transportation management systems. Unfortunately, small organizations with limited resources are less likely to adopt transportation management systems, despite the need for such automation. One solution is to use available productivity software to track and manage driver route activity in an effort to improve and maintain driver productivity by reducing non-value time and identifying optimal routes. This paper will outline how office productivity software such as Microsoft® Access can meet the needs of small organizations with limited resources by describing the development and use of a route activity database that employs an easy-to-use multi-user interface. This paper also includes the details of the underlying infrastructure and the user interface.

  15. An Introduction to Cochlear Implant Technology, Activation, and Programming.

    Science.gov (United States)

    Moore, Jan A.; Teagle, Holly F. B.

    2002-01-01

    This article provides information about the hardware components and speech-processing strategies of cochlear implant systems. The use of assistive listening devices with cochlear implants is also discussed. A brief description of surgical procedures and the initial activation of the device are also presented, along with programming considerations.…

  16. Visual Sensor Technology for Advanced Surveillance Systems: Historical View, Technological Aspects and Research Activities in Italy

    Directory of Open Access Journals (Sweden)

    Lauro Snidaro

    2009-03-01

    Full Text Available The paper is a survey of the main technological aspects of advanced visual-based surveillance systems. A brief historical view of such systems from the origins to nowadays is given together with a short description of the main research projects in Italy on surveillance applications in the last twenty years. The paper then describes the main characteristics of an advanced visual sensor network that (a directly processes locally acquired digital data, (b automatically modifies intrinsic (focus, iris and extrinsic (pan, tilt, zoom parameters to increase the quality of acquired data and (c automatically selects the best subset of sensors in order to monitor a given moving object in the observed environment.

  17. Promoting Active Learning in Technology-Infused TILE Classrooms at the University of Iowa

    Directory of Open Access Journals (Sweden)

    Sam Van Horne

    2012-06-01

    Full Text Available In this case study, the authors describe the successful implementation of technology-infused TILE classrooms at the University of Iowa. A successful collaboration among campus units devoted to instructional technologies and teacher development, the TILE Initiative has provided instructors with a new set of tools to support active learning. The authors detail the implementation of the TILE classrooms, the process of training instructors to design effective instruction for these classrooms, and an assessment project that helps improve the process of ensuring faculty can successfully facilitate learning activities in a technology-infused learning environment.

  18. Modern and prospective technologies for weather modification activities: A look at integrating unmanned aircraft systems

    Science.gov (United States)

    Axisa, Duncan; DeFelice, Tom P.

    2016-09-01

    Present-day weather modification technologies are scientifically based and have made controlled technological advances since the late 1990s, early 2000s. The technological advances directly related to weather modification have primarily been in the decision support and evaluation based software and modeling areas. However, there have been some technological advances in other fields that might now be advanced enough to start considering their usefulness for improving weather modification operational efficiency and evaluation accuracy. We consider the programmatic aspects underlying the development of new technologies for use in weather modification activities, identifying their potential benefits and limitations. We provide context and initial guidance for operators that might integrate unmanned aircraft systems technology in future weather modification operations.

  19. NASA Activities as they Relate to Microwave Technology for Aerospace Communications Systems

    Science.gov (United States)

    Miranda, Felix A.

    2011-01-01

    This presentation discusses current NASA activities and plans as they relate to microwave technology for aerospace communications. The presentations discusses some examples of the aforementioned technology within the context of the existing and future communications architectures and technology development roadmaps. Examples of the evolution of key technology from idea to deployment are provided as well as the challenges that lay ahead regarding advancing microwave technology to ensure that future NASA missions are not constrained by lack of communication or navigation capabilities. The presentation closes with some examples of emerging ongoing opportunities for establishing collaborative efforts between NASA, Industry, and Academia to encourage the development, demonstration and insertion of communications technology in pertinent aerospace systems.

  20. Keys to active ageing: new communication technologies and lifelong learning.

    Science.gov (United States)

    Díaz-López, M Del Pilar; López-Liria, Remedios; Aguilar-Parra, José M; Padilla-Góngora, David

    2016-01-01

    The purpose of this study is to describe the creation and implementation of an ICT education program for the elderly in various Active Participation Centers in Almería (Spain), assessing its impact on quality of life. From a randomized sample of 200 individuals over the age of 55. Results reveal a high degree of participant satisfaction (76.6 %), as well as improvements in quality of life as compared to the control group after the 3 month program health factor: p = 0.004; leisure and activity factor: p = 0.001; Satisfaction with Life Factor: p higher scores) and gender (the males). This study may serve to facilitate similar works that promotes on-going education in different locations and across the lifespan.

  1. Improving Physical Activity and Health with Information Technology

    OpenAIRE

    Koskivaara, Eija

    2014-01-01

    Part 2: Digital Society; International audience; Physical inactivity and overweight/obesity kill 6 million people yearly [1]. Regular physical activity (PA) such as walking, cycling, or participating in sports has significant benefits for health and weight-loss maintenance. It reduces of the risk of diseases, e.g. diabetes, depression, or helps weight controlling. This one year case study explores how daily monitoring of objective PA and weight effects on body mass index (BMI) -value when the...

  2. Activation of protein kinase A and exchange protein directly activated by cAMP promotes adipocyte differentiation of human mesenchymal stem cells.

    Directory of Open Access Journals (Sweden)

    Bingbing Jia

    Full Text Available Human mesenchymal stem cells are primary multipotent cells capable of differentiating into several cell types including adipocytes when cultured under defined in vitro conditions. In the present study we investigated the role of cAMP signaling and its downstream effectors, protein kinase A (PKA and exchange protein directly activated by cAMP (Epac in adipocyte conversion of human mesenchymal stem cells derived from adipose tissue (hMADS. We show that cAMP signaling involving the simultaneous activation of both PKA- and Epac-dependent signaling is critical for this process even in the presence of the strong adipogenic inducers insulin, dexamethasone, and rosiglitazone, thereby clearly distinguishing the hMADS cells from murine preadipocytes cell lines, where rosiglitazone together with dexamethasone and insulin strongly promotes adipocyte differentiation. We further show that prostaglandin I(2 (PGI(2 may fully substitute for the cAMP-elevating agent isobutylmethylxanthine (IBMX. Moreover, selective activation of Epac-dependent signaling promoted adipocyte differentiation when the Rho-associated kinase (ROCK was inhibited. Unlike the case for murine preadipocytes cell lines, long-chain fatty acids, like arachidonic acid, did not promote adipocyte differentiation of hMADS cells in the absence of a PPARγ agonist. However, prolonged treatment with the synthetic PPARδ agonist L165041 promoted adipocyte differentiation of hMADS cells in the presence of IBMX. Taken together our results emphasize the need for cAMP signaling in concert with treatment with a PPARγ or PPARδ agonist to secure efficient adipocyte differentiation of human hMADS mesenchymal stem cells.

  3. Hydrogen/Deuterium Exchange Mass Spectrometry Reveals Specific Changes in the Local Flexibility of Plasminogen Activator Inhibitor 1 upon Binding to the Somatomedin B Domain of Vitronectin

    DEFF Research Database (Denmark)

    Trelle, Morten Beck; Hirschberg, Daniel; Jansson, Anna

    2012-01-01

    and increases the thermal stability of the protein dramatically. We have used hydrogen/deuterium exchange mass spectrometry to assess the inherent structural flexibility of PAI-1 and to monitor the changes induced by SMB binding. Our data show that the PAI-1 core consisting of β-sheet B is rather protected......The native fold of plasminogen activator inhibitor 1 (PAI-1) represents an active metastable conformation that spontaneously converts to an inactive latent form. Binding of the somatomedin B domain (SMB) of the endogenous cofactor vitronectin to PAI-1 delays the transition to the latent state...... against exchange with the solvent, while the remainder of the molecule is more dynamic. SMB binding causes a pronounced and widespread stabilization of PAI-1 that is not confined to the binding interface with SMB. We further explored the local structural flexibility in a mutationally stabilized PAI-1...

  4. Direct imaging of thermally-activated grain-boundary diffusion in Cu/Co/IrMn/Pt exchange-bias structures using atom-probe tomography

    Energy Technology Data Exchange (ETDEWEB)

    Letellier, F.; Lardé, R.; Le Breton, J.-M., E-mail: jean-marie.lebreton@univ-rouen.fr [Groupe de Physique des Matériaux, UMR 6634 CNRS/Université et INSA de Rouen, F-76801 Saint Etienne du Rouvray (France); Lechevallier, L. [Groupe de Physique des Matériaux, UMR 6634 CNRS/Université et INSA de Rouen, F-76801 Saint Etienne du Rouvray (France); Département de GEII, Université de Cergy-Pontoise, F-95031 Cergy-Pontoise (France); Akmaldinov, K. [SPINTEC, Univ. Grenoble-Alpes/CNRS/INAC-CEA, F-38000 Grenoble (France); CROCUS Technology, F-38025 Grenoble (France); Auffret, S.; Dieny, B.; Baltz, V., E-mail: vincent.baltz@cea.fr [SPINTEC, Univ. Grenoble-Alpes/CNRS/INAC-CEA, F-38000 Grenoble (France)

    2014-11-28

    Magnetic devices are often subject to thermal processing steps, such as field cooling to set exchange bias and annealing to crystallize amorphous magnetic electrodes. These processing steps may result in interdiffusion and the subsequent deterioration of magnetic properties. In this study, we investigated thermally-activated diffusion in Cu/Co/IrMn/Pt exchange biased polycrystalline thin-film structures using atom probe tomography. Images taken after annealing at 400 °C for 60 min revealed Mn diffusion into Co grains at the Co/IrMn interface and along Pt grain boundaries for the IrMn/Pt stack, i.e., a Harrison type C regime. Annealing at 500 °C showed further Mn diffusion into Co grains. At the IrMn/Pt interface, annealing at 500 °C led to a type B behavior since Mn diffusion was detected both along Pt grain boundaries and also into Pt grains. The deterioration of the films' exchange bias properties upon annealing was correlated to the observed diffusion. In particular, the topmost Pt capping layer thickness turned out to be crucial since a faster deterioration of the exchange bias properties for thicker caps was observed. This is consistent with the idea that Pt acts as a getter for Mn, drawing Mn out of the IrMn layer.

  5. Management of female handball players' activity applying interactive technologies

    Directory of Open Access Journals (Sweden)

    Frolova L.S.

    2012-04-01

    Full Text Available The efficiency of developed methods for the control of female handball players' readiness to competitive activity was determined. The opportunities of team management regarding the specification of playing role, the formation of the starting line of players and the replacement according to game priorities in attack or defense were considered. The availability of the adequate zone of handball players' mobilizing readiness that allows to have a significant influence on individual effectiveness in the conditions of optimal management and to increase the quality of team game was determined.

  6. Integrated Foreign Exchange Risk Management

    DEFF Research Database (Denmark)

    Aabo, Tom; Høg, Esben; Kuhn, Jochen

    Empirical research has focused on export as a proxy for the exchange rate exposure and the use of foreign exchange derivatives as the instrument to deal with this exposure. This empirical study applies an integrated foreign exchange risk management approach with a particular focus on the role...... of import in medium-sized, manufacturing firms in Denmark (a small, open economy). We find a strong, negative relation between import and foreign exchange derivatives usage on the aggregate level. Our findings are consistent with the notion that firms use import to match the foreign exchange exposure...... created by foreign sales activities....

  7. Heat exchanger

    Energy Technology Data Exchange (ETDEWEB)

    Craig, L.B.; Farma, A.J.

    1987-01-06

    This invention concerns a heat exchanger as used in a space heater, of the type in which hot exhaust gases transfer heat to water or the like flowing through a helical heat exchange coil. A significant improvement to the efficiency of the heat exchange occurring between the air and water is achieved by using a conduit for the water having external helical fluting such that the hot gases circulate along two paths, rather than only one. A preferred embodiment of such a heat exchanger includes a porous combustion element for producing radiant heat from a combustible gas, surrounded by a helical coil for effectively transferring the heat in the exhaust gas, flowing radially from the combustion element, to the water flowing through the coil. 4 figs.

  8. Oil and gas technology transfer activities and potential in eight major producing states. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    1993-07-01

    In 1990, the Interstate Oil and Gas Compact Commission (the Compact) performed a study that identified the structure and deficiencies of the system by which oil and gas producers receive information about the potential of new technologies and communicate their problems and technology needs back to the research community. The conclusions of that work were that major integrated companies have significantly more and better sources of technology information than independent producers. The majors also have significantly better mechanisms for communicating problems to the research and development (R&D) community. As a consequence, the Compact recommended analyzing potential mechanisms to improve technology transfer channels for independents and to accelerate independents acceptance and use of existing and emerging technologies. Building on this work, the Compact, with a grant from the US Department Energy, has reviewed specific technology transfer organizations in each of eight major oil producing states to identify specific R&D and technology transfer organizations, characterize their existing activities, and identify potential future activities that could be performed to enhance technology transfer to oil and gas producers. The profiles were developed based on information received from organizations,follow-up interviews, site visit and conversations, and participation in their sponsored technology transfer activities. The results of this effort are reported in this volume. In addition, the Compact has also developed a framework for the development of evaluation methodologies to determine the effectiveness of technology transfer programs in performing their intended functions and in achieving desired impacts impacts in the producing community. The results of that work are provided in a separate volume.

  9. Technology Development Report: CDDF, Dual Use Partnerships, SBIR/STTR: Fiscal Year 2003 Activities

    Science.gov (United States)

    Bailey, John W.

    2004-01-01

    The FY2003 NASA John C. Stennis Stennis Space Center (SSC) Technology Development Report provides an integrated report of all technology development activities at SSC. This report actually combines three annual reports: the Center Director's Discretionary Fund (CDDF) Program Report, Dual Use Program Report, and the Small Business Innovation Research (SBIR)/Small Business Technology Transfer (STTR) Program Report. These reports are integrated in one document to summarize all technology development activities underway in support of the NASA missions assigned to SSC. The Dual Use Program Report provides a summary review of the results and status of the nine (9) Dual Use technology development partnership projects funded and managed at SSC during FY2003. The objective of these partnership projects is to develop or enhance technologies that will meet the technology needs of the two NASA SSC Mission Areas: Propulsion Test and Earth Science Applications. During FY2003, the TDTO managed twenty (20) SBIR Phase II Projects and two (2) STTR Phase II Projects. The SBIR contracts support low TRL technology development that supports both the Propulsion Test and the Earth Science Application missions. These projects are shown in the SBIR/STTR Report. In addition to the Phase II contracts, the TDTO managed ten (10) SBIR Phase I contracts which are fixed price, six month feasibility study contracts. These are not listed in this report. Together, the Dual Use Projects and the SBIR/STTR Projects constitute a technology development partnership approach that has demonstrated that success can be achieved through the identification of the technical needs of the NASA mission and using various available partnership techniques to maximize resource utilization to achieve mutual technology goals. Greater use of these partnership techniques and the resource leveraging they provide, is a goal of the TDTO, providing more support to meet the technology development needs of the mission areas at

  10. Effects of a Physical Education Supportive Curriculum and Technological Devices on Physical Activity

    Science.gov (United States)

    Clapham, Emily Dean; Sullivan, Eileen C.; Ciccomascolo, Lori E.

    2015-01-01

    The purpose of this study was to examine the effects of a physical education supportive curriculum and technological devices, heart rate monitor (HRM) and pedometer (PED), on physical activity. A single-subject ABAB research design was used to examine amount and level of participation in physical activity among 106 suburban fourth and fifth…

  11. BULK VITRIFICATION TECHNOLOGY FOR THE TREATMENT AND IMMOBILIZATION OF LOW-ACTIVITY WASTE

    Energy Technology Data Exchange (ETDEWEB)

    ARD KE

    2011-04-11

    This report is one of four reports written to provide background information regarding immobilization technologies under consideration for supplemental immobilization of Hanford's low-activity waste. This paper is intended to provide the reader with general understanding of Bulk Vitrification and how it might be applied to immobilization of Hanford's low-activity waste.

  12. Science and Technology Librarians: User Engagement and Outreach Activities in the Area of Scholarly Communication

    Science.gov (United States)

    Salisbury, Lutishoor; Speer, Julie

    2016-01-01

    This paper highlights the findings of a survey completed by ACRL/STS [Association of College and Research Libraries/Science and Technology Section] members on scholarly communication issues. In particular it identifies the percentage of their daily activities that are spent in support of scholarly communication activities; extent of change of job…

  13. Effects of a Physical Education Supportive Curriculum and Technological Devices on Physical Activity

    Science.gov (United States)

    Clapham, Emily Dean; Sullivan, Eileen C.; Ciccomascolo, Lori E.

    2015-01-01

    The purpose of this study was to examine the effects of a physical education supportive curriculum and technological devices, heart rate monitor (HRM) and pedometer (PED), on physical activity. A single-subject ABAB research design was used to examine amount and level of participation in physical activity among 106 suburban fourth and fifth…

  14. A JOULE-HEATED MELTER TECHNOLOGY FOR THE TREATMENT AND IMMOBILIZATION OF LOW-ACTIVITY WASTE

    Energy Technology Data Exchange (ETDEWEB)

    KELLY SE

    2011-04-07

    This report is one of four reports written to provide background information regarding immobilization technologies remaining under consideration for supplemental immobilization of Hanford's low-activity waste. This paper provides the reader a general understanding of joule-heated ceramic lined melters and their application to Hanford's low-activity waste.

  15. Exploration of Tensions in a Mobile-Technology Supported Fieldtrip: An Activity Theory Perspective

    Science.gov (United States)

    Lai, Chih-Hung; Chen, Fei-Ching; Yang, Jie-Chi

    2014-01-01

    The purpose of this study was to analyze how mobile technologies were incorporated and implemented in an outdoor learning activity. Two classes of primary school students participated in the experiment. Using activity theory as an analytical framework, it is found that underlying tensions provided rich insights into system dynamics and that…

  16. 发展中国椰子科技国际合作交流的探析%Discusses on Developing Chinese Coconut Science and Technology International Cooperation and Exchange

    Institute of Scientific and Technical Information of China (English)

    许丽菁; 范海阔; 杨耀东; 郑小蔚; 董志国

    2014-01-01

    介绍加强椰子科技国际合作交流的背景及中国椰子科技国际合作概况,分析中国椰子产业缺乏具有国际竞争和科技含量高的椰子深加工产品,缺乏高层次椰子科技国际合作交流的人才,缺乏与国外科研机构合作开发较大的椰子产业的科研项目等我国椰子科技国际合作存在的问题,针对以上问题对中国椰子科技国际合作交流的进一步发展提出了建议。%This paper describes the background for strengthening international cooperation and exchange in coconut science and technology and gives the overview of Chinese coconut science and technology international cooperation, following by analysis of the problems of Chinese coconut science and technology international cooperation such as being lack of internationally competitive high-tech and deep processing coconut products in Chinese coconut industry, being lack of high-level coconut scientific and technological cooperation and exchange of international talent, being lack of developing larger cooperation research projects in coconut industry with foreign research institutions. At last, this paper proposed suggestions about developing Chinese coconut science and technology international cooperation and exchange.

  17. Solvent Dynamical Effects in Electron Transfer: Electrochemical-Exchange Kinetics of Sesquibicyclic Hydrazines as a Probe of Coupled Vibrational Activation

    Science.gov (United States)

    1992-10-01

    Wisconsin group shows that a significantly better correlation of the solvent-dependent kinetics are obtained with the Kosower Z parameter than with the...log kh1 for 1+/0 self exchange in nine solvents, including three alcohols, correlates linearly with the Kosower Z or the closely related E?(30

  18. Radiosynthesis of [{sup 18}F]fluorophenyl-L-amino acids by isotopic exchange on carbonyl-activated precursors

    Energy Technology Data Exchange (ETDEWEB)

    Castillo Melean, Johnny

    2011-02-01

    Aromatic [{sup 18}F]fluoroamino acids have earlier been developed as promising probes for diagnostics using PET. However, a wider use of these radiofluorinated compounds has been limited due to radiosynthetic constraints. The work here presents an amenable three-step radiosynthesis pathway for the preparation of 2-[{sup 18}F]fluoro-L-phenylalanine (2-[{sup 18}F]Fphe), 2-[{sup 18}F]fluoro-L-tyrosine (2-[{sup 18}F]Ftyr), 6-[{sup 18}F]fuoro-L-m-tyrosine (6-[{sup 18}F]Fmtyr) and 6-[{sup 18}F]fluoro-L-DOPA (6-[{sup 18}F]FDOPA). For this, corresponding precursors were {sup 18}F-fluorinated by nucleophilic isotopic exchange, followed by either removal of an activating formyl group with Rh(PPh{sub 3}){sub 3}Cl or its conversion by Baeyer-Villiger oxidation, respectively, and subsequent hydrolysis of protecting groups in acidic medium. Two efficient synthetic approaches were developed for the preparation of highly functionalized fluoro-benzaldehydes and -ketones which were used as labeling precursors. The compounds (2S,5S)-tert-butyl 2-tert-butyl-5-(2-fluoro-5-formylbenzyl)-3-methyl-4-oxoimidazolidine-1 -carboxylate (1a), (2S,5S)-tert-butyl 5-(5-acetyl-2-fluorobenzyl)-2-tert-butyl-3-methyl-4-oxoimidazolidine-1 -carboxylate (1c), (2S,5S)-benzyl 2-tert-butyl-5-(2-fluoro-5-formylbenzyl)-3-methyl-4-oxoimidazolidine-1 -carbo-xylate (1d), 4-fluoro-3-(((2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl) me-thyl)b enzal-dehyde (1e) and 1-(4-fluoro-3-(((2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl) me-thy l)phenyl)ethanone (1f), could be prepared in six steps and overall yields of 41%, 48%, 37%, 27%, and 32%, respectively. (2S,5S)-tert-Butyl 5-(4-(benzyloxy)-2-fluoro-5-formylbenzyl)-2-tert-butyl-3-methyl-4 -oxoimidazolidi ne-1-carboxylate (1b) was prepared in ten steps with an overall yield of 19% while compounds (2S,5S)-tert-butyl 5-(5-(3,5-bis(trifluoromethyl)-benzoyl)-2-fluorobenzyl)-2-tert-butyl-3 -methyl-4-oxoimidazolidine-1-carboxylate (1g) and (2S,5S

  19. Dynamics in Thermotoga neapolitana adenylate kinase: 15N relaxation and hydrogen-deuterium exchange studies of a hyperthermophilic enzyme highly active at 30 degrees C.

    Science.gov (United States)

    Krishnamurthy, Harini; Munro, Kim; Yan, Honggao; Vieille, Claire

    2009-03-31

    Backbone conformational dynamics of Thermotoga neapolitana adenylate kinase in the free form (TNAK) and inhibitor-bound form (TNAK*Ap5A) were investigated at 30 degrees C using (15)N NMR relaxation measurements and NMR monitored hydrogen-deuterium exchange. With kinetic parameters identical to those of Escherichia coli AK (ECAK) at 30 degrees C, TNAK is a unique hyperthermophilic enzyme. These catalytic properties make TNAK an interesting and novel model to study the interplay between protein rigidity, stability, and activity. Comparison of fast time scale dynamics (picosecond to nanosecond) in the open and closed states of TNAK and ECAK at 30 degrees C reveals a uniformly higher rigidity across all domains of TNAK. Within this framework of a rigid TNAK structure, several residues located in the AMP-binding domain and in the core-lid hinge regions display high picosecond to nanosecond time scale flexibility. Together with the recent comparison of ECAK dynamics with those of hyperthermophilic Aquifex aeolicus AK (AAAK), our results provide strong evidence for the role of picosecond to nanosecond time scale fluctuations in both stability and activity. In the slow time scales, TNAK's increased rigidity is not uniform but localized in the AMP-binding and lid domains. The core domain amides of ECAK and TNAK in the open and closed states show comparable protection against exchange. Significantly, the hinges framing the lid domain show similar exchange data in ECAK and TNAK open and closed forms. Our NMR relaxation and hydrogen-deuterium exchange studies therefore suggest that TNAK maintains high activity at 30 degrees C by localizing flexibility to the hinge regions that are key to facilitating conformational changes.

  20. Hollow mesoporous titania microspheres: New technology and enhanced photocatalytic activity

    Science.gov (United States)

    Feng, Zhenliang; Wei, Wenrui; Wang, Litong; Hong, Ruoyu

    2015-12-01

    Hollow titania microspheres (HTS) were fabricated via a sol-gel process by coating the hydrolysis product of titanium tetrabutoxide (TBOT) onto the amino (-NH2) modified porous polystyrene cross-linked divinyl benzene (PS-DVB) microspheres under changing atmospheric pressure, followed by calcination in nitrogen and air atmosphere. Particularly, the atmospheric pressure was continuously and regularly changed during the formation process of PS-DVB@TiO2 microspheres. Then the TiO2 particles were absorbed into the pores and onto the surface of PS-DVB as well. The resultant HTS (around 2 μm in diameter) featured a high specific surface area (84.37 m2/g), anatase crystal and stable hollow microsphere structure, which led to high photocatalysis activity. The photocatalytic degradation of malachite green (MG) organic dye solution was conducted under ultraviolet (UV) light irradiation, which showed a high photocatalytic ability (81% of MG was degraded after UV irradiation for 88 min). Therefore, it could be potentially applied for the treatment of wastewater contaminated by organic pollutants.

  1. Computing in mammalian cells with nucleic acid strand exchange

    Science.gov (United States)

    Groves, Benjamin; Chen, Yuan-Jyue; Zurla, Chiara; Pochekailov, Sergii; Kirschman, Jonathan L.; Santangelo, Philip J.; Seelig, Georg

    2016-03-01

    DNA strand displacement has been widely used for the design of molecular circuits, motors, and sensors in cell-free settings. Recently, it has been shown that this technology can also operate in biological environments, but capabilities remain limited. Here, we look to adapt strand displacement and exchange reactions to mammalian cells and report DNA circuitry that can directly interact with a native mRNA. We began by optimizing the cellular performance of fluorescent reporters based on four-way strand exchange reactions and identified robust design principles by systematically varying the molecular structure, chemistry and delivery method. Next, we developed and tested AND and OR logic gates based on four-way strand exchange, demonstrating the feasibility of multi-input logic. Finally, we established that functional siRNA could be activated through strand exchange, and used native mRNA as programmable scaffolds for co-localizing gates and visualizing their operation with subcellular resolution.

  2. Managing Social Activity and Participation in Large Classes with Mobile Phone Technology

    Directory of Open Access Journals (Sweden)

    A. Thatcher

    2008-07-01

    Full Text Available Within the context of a developing country, suchas South Africa, access to technology is severely limited.However, most South Africans have relatively good access tomobile phone technology in relation to other portable andmobile technology. In this initiative, students wereencouraged to use mobile phone text messaging to sendquestions to the lecturer during classes or between classes. Atotal of 86 text messages were sent to the lecturer during a 7-week, second year psychology course. At the end of thecourse 136 responses to questionnaire distributed in classwas obtained. This data was analysed using activity theoryas a framework for the discussion. The results indicated thatstudents had strongly favorable perceptions of this initiativeand respondents had spontaneously suggested other uses ofmobile phone technology to enhance the learningexperience. Activity theory provided a useful framework forevaluating the use of mobile phone text messages to enhancestudent participation and learning.

  3. The Role of Technology in Science Teaching Activities: Web Based Teaching Applications

    Directory of Open Access Journals (Sweden)

    Fatma ALKAN

    2016-12-01

    Full Text Available 2015 Abstract In this research the attitudes of pre-service teachers studying at Hacettepe University, Division of Science Education towards the importance of technological equipment in chemistry education activities and how effective they find technology in teaching different skills and applications have been examined. Pre-test/post-test control group design has been used in the research. In the experimental group Titrimetric Analysis has been conducted with simulations supported web based instruction and in the control group with teacher-centered instruction. In general, it has been found out that the attitudes of pre-service teachers in experiment group towards the importance of technological equipment as a teaching tool in chemistry are more positive than those in control group. In other words, statistically significant differences have occurred in attitudes of pre-service teachers in both experiment and control group towards the role of technology in chemistry teaching activities after web based teaching.

  4. The impact of active controls technology on the structural integrity of aeronautical vehicles

    Science.gov (United States)

    Noll, Thomas E.; Austin, Edward; Donley, Shawn; Graham, George; Harris, Terry; Kaynes, Ian; Lee, Ben; Sparrow, James

    1993-01-01

    The findings of an investigation conducted under the auspices of The Technical Cooperation Program (TTCP) to assess the impact of active controls technology on the structural integrity of aeronautical vehicles and to evaluate the present state-of-the-art for predicting loads caused by a flight-control system modification and the resulting change in the fatigue life of the flight vehicle are summarized. Important points concerning structural technology considerations implicit in applying active controls technology in new aircraft are summarized. These points are well founded and based upon information received from within the aerospace industry and government laboratories, acquired by sponsoring workshops which brought together experts from contributing and interacting technical disciplines, and obtained by conducting a case study to independently assess the state of the technology. The paper concludes that communication between technical disciplines is absolutely essential in the design of future high performance aircraft.

  5. NASA's Advanced Propulsion Technology Activities for Third Generation Fully Reusable Launch Vehicle Applications

    Science.gov (United States)

    Hueter, Uwe

    2000-01-01

    NASA's Office of Aeronautics and Space Transportation Technology (OASTT) established the following three major goals, referred to as "The Three Pillars for Success": Global Civil Aviation, Revolutionary Technology Leaps, and Access to Space. The Advanced Space Transportation Program Office (ASTP) at the NASA's Marshall Space Flight Center in Huntsville, Ala. focuses on future space transportation technologies under the "Access to Space" pillar. The Propulsion Projects within ASTP under the investment area of Spaceliner100, focus on the earth-to-orbit (ETO) third generation reusable launch vehicle technologies. The goals of Spaceliner 100 is to reduce cost by a factor of 100 and improve safety by a factor of 10,000 over current conditions. The ETO Propulsion Projects in ASTP, are actively developing combination/combined-cycle propulsion technologies that utilized airbreathing propulsion during a major portion of the trajectory. System integration, components, materials and advanced rocket technologies are also being pursued. Over the last several years, one of the main thrusts has been to develop rocket-based combined cycle (RBCC) technologies. The focus has been on conducting ground tests of several engine designs to establish the RBCC flowpaths performance. Flowpath testing of three different RBCC engine designs is progressing. Additionally, vehicle system studies are being conducted to assess potential operational space access vehicles utilizing combined-cycle propulsion systems. The design, manufacturing, and ground testing of a scale flight-type engine are planned. The first flight demonstration of an airbreathing combined cycle propulsion system is envisioned around 2005. The paper will describe the advanced propulsion technologies that are being being developed under the ETO activities in the ASTP program. Progress, findings, and future activities for the propulsion technologies will be discussed.

  6. 换热管内旋转超声检测技术%IRIS Ultrasonic Inspection Technology of Heat Exchanger Tubes

    Institute of Scientific and Technical Information of China (English)

    肖雄

    2013-01-01

    主要介绍测量换热管厚度(受腐蚀、冲蚀等损伤)的一项超声检测技术---内旋转检测系统( IRIS),其主要用途是对在役的换热管进行壁厚测量,超声波探头通过对中装置在充满水的管子内部以螺旋的方式检测,通过计算机软件的相关处理,得到管子管壁的C扫描、B扫描、D扫描图像,通过分析便可以检测到一些壁厚减薄类的缺陷,包括表面的腐蚀、介质冲刷造成的冲蚀、管子振动造成的表面损伤等,并通过对比涡流检测,让用户更清楚地了解IRIS检测的优缺点,在实际检修过程中合理选择最佳的检测方法。%A technique based on ultrasonic thickness measuring technology---IRIS ( Internal Rotary In-spection System ) was introduced .IRIS main purpose is for the heat exchanger tubes wall thickness meas-urement in service ,the ultrasonic probe in centring devices inside water -filled tube in a spiral manner testing ,and processing by computer software ,to obtain the images of C -scan and B-scan and D-scan of the tube wall,image be used by the analysis software can see some defects of wall thinning ,including the corrosion of the tube surface ,erosion caused by the erosion medium ,the tube surface damage caused by vibration,etc.,and by comparing with the eddy current testing ,the users can be more clearly under-stand the advantages and disadvantages of IRIS testing in the actual need ,easy to select different testing methods,to achieve the purposes of better inspection .

  7. Harpoon technology development for the active removal of space debris

    Science.gov (United States)

    Dudziak, Roger; Tuttle, Sean; Barraclough, Simon

    2015-08-01

    This paper presents the results of preliminary empirical testing and numerical modelling carried out to demonstrate the effectiveness of using a harpoon in an ADR application. Empirical testing involving the impact of blunt and conical shaped steel tips into 3 mm Al plate showed that the ballistic limit varies in proportion to the tip circumference, with conical shapes resulting in a higher relative ballistic limit due to the additional energy required for petaling. The creation of secondary debris was also monitored. It was found that blunt shapes created a plug during penetration as a result of shearing around the periphery of the projectile, whilst conical tips resulted in minor spalling and fragmentation. Preliminary oblique impact testing with conical and blunt tips showed that the ballistic limit increases with obliquity at a greater rate for blunt tips than conical ones. Impact testing of 3 mm Al plate with conical projectiles at low temperatures showed a more brittle fracture mode when compared with targets impacted at room temperature. As such, the fragmentation and spalling evident in room temperature targets was absent. The energy required to perforate the cooled plates also increased. Impact testing of Al panel obstructed with fixed heat pipes showed that the harpoon could successfully penetrate a target panel with such an obstruction due to shearing of the pipe flange. Testing of two lock on mechanisms showed that both a spring activated and integrated toggle could reliably open upon impact. This testing also used a tensile testing machine to show that both designs could withstand the force expected during deorbiting manoeuvres after impact with Al H/C panels. A parametric simulation comparing the diameter of conical tips with ballistic limits showed a good agreement with the predictions of De Marre's formula for normal impact. This suggests that the ballistic limit of plates impacted by conical projectiles can be successfully extrapolated with limited

  8. Promoting Active Learning in Technology-Infused TILE Classrooms at the University of Iowa

    OpenAIRE

    Sam Van Horne; Cecilia Murniati; Jon D. H. Gaffney; Maggie Jesse

    2012-01-01

    In this case study, the authors describe the successful implementation of technology-infused TILE classrooms at the University of Iowa. A successful collaboration among campus units devoted to instructional technologies and teacher development, the TILE Initiative has provided instructors with a new set of tools to support active learning. The authors detail the implementation of the TILE classrooms, the process of training instructors to design effective instruction for these classrooms, and...

  9. Acclimation to high CO/sub 2/ in monoecious cucumbers. II. Carbon exchange rates, enzyme activities, and starch and nutrient concentrations. [Cucumis sativus L

    Energy Technology Data Exchange (ETDEWEB)

    Peet, M.M.; Huber, S.C.; Patterson, D.T.

    1986-01-01

    Carbon exchange capacity of cucumber (Cucumis sativus L.) germinated and grown in controlled environment chambers at 1000 microliters per liter CO/sub 2/ decreased from the vegetative growth stage to the fruiting stage, during which time capacity of plants grown at 350 microliters per liter increased. Carbon exchange rates (CERs) measured under growth conditions during the fruiting period were, in fact, lower in plants grown at 1000 microliters per liter CO/sub 2/ than those grown at 350. Progressive decreases in CERs in 1000 microliters per liter plants were associated with decreasing stomatal conductances and activities of ribulose bisphosphate carboxylase and carbonic anhydrase. Leaf starch concentrations were higher in 1000 microliters per liter CO/sub 2/ grown-plants than in 350 microliters per liter grown plants but calcium and nitrogen concentrations were lower, the greatest difference occurring at flowering. Sucrose synthase and sucrose-P-synthase activities were similar in 1000 microliters per liter compared to 350 microliters per liter plants during vegetative growth and flowering but higher in 350 microliters per liter plants at fruiting. The decreased carbon exchange rates observed in this cultivar at 1000 microliters per liter CO/sub 2/ could explain the lack of any yield increase when compared with plants grown at 350 microliters per liter.

  10. Activity Theory as a Framework for Investigating District-Classroom System Interactions and Their Influences on Technology Integration

    Science.gov (United States)

    Anthony, Anika Ball

    2012-01-01

    Technology implementation research indicates that teachers' beliefs and knowledge, as well as a host of institutional factors, can influence technology integration. Drawing on third-generation activity theory, this article conceptualizes technology implementation as a network of planning and integration activities carried out by technology…

  11. Alternate particle removal technologies for the Airborne Activity Confinement System at the Savannah River Site

    Energy Technology Data Exchange (ETDEWEB)

    Brockmann, J.E.; Adkins, C.L.J.; Gelbard, F. [Sandia National Labs., Albuquerque, NM (United States)

    1991-09-01

    This report presents a review of the filtration technologies available for the removal of particulate material from a gas stream. It was undertaken to identify alternate filtration technologies that may be employed in the Airborne Activity Confinement System (AACS) at the Savannah River Plant. This report is organized into six sections: (1) a discussion of the aerosol source term and its definition, (2) a short discussion of particle and gaseous contaminant removal mechanisms, (3) a brief overview of particle removal technologies, (4) a discussion of the existing AACS and its potential shortcomings, (5) an enumeration of issues to be addressed in upgrading the AACS, and, (6) a detailed discussion of the identified technologies. The purpose of this report is to identity available options to the existing particle removal system. This system is in continuous operation during routine operation of the reactor. As will be seen, there are a number of options and the selection of any technology or combination of technologies will depend on the design aerosol source term (yet to be appropriately defined) as well as the flow requirements and configuration. This report does not select a specific technology. It focuses on particulate removal and qualitatively on the removal of radio-iodine and mist elimination. Candidate technologies have been selected from industrial and nuclear gas cleaning applications.

  12. Alternate particle removal technologies for the Airborne Activity Confinement System at the Savannah River Site

    Energy Technology Data Exchange (ETDEWEB)

    Brockmann, J.E.; Adkins, C.L.J.; Gelbard, F. (Sandia National Labs., Albuquerque, NM (United States))

    1991-09-01

    This report presents a review of the filtration technologies available for the removal of particulate material from a gas stream. It was undertaken to identify alternate filtration technologies that may be employed in the Airborne Activity Confinement System (AACS) at the Savannah River Plant. This report is organized into six sections: (1) a discussion of the aerosol source term and its definition, (2) a short discussion of particle and gaseous contaminant removal mechanisms, (3) a brief overview of particle removal technologies, (4) a discussion of the existing AACS and its potential shortcomings, (5) an enumeration of issues to be addressed in upgrading the AACS, and, (6) a detailed discussion of the identified technologies. The purpose of this report is to identity available options to the existing particle removal system. This system is in continuous operation during routine operation of the reactor. As will be seen, there are a number of options and the selection of any technology or combination of technologies will depend on the design aerosol source term (yet to be appropriately defined) as well as the flow requirements and configuration. This report does not select a specific technology. It focuses on particulate removal and qualitatively on the removal of radio-iodine and mist elimination. Candidate technologies have been selected from industrial and nuclear gas cleaning applications.

  13. Active assistance technology for health-related behavior change: an interdisciplinary review.

    Science.gov (United States)

    Kennedy, Catriona M; Powell, John; Payne, Thomas H; Ainsworth, John; Boyd, Alan; Buchan, Iain

    2012-06-14

    Information technology can help individuals to change their health behaviors. This is due to its potential for dynamic and unbiased information processing enabling users to monitor their own progress and be informed about risks and opportunities specific to evolving contexts and motivations. However, in many behavior change interventions, information technology is underused by treating it as a passive medium focused on efficient transmission of information and a positive user experience. To conduct an interdisciplinary literature review to determine the extent to which the active technological capabilities of dynamic and adaptive information processing are being applied in behavior change interventions and to identify their role in these interventions. We defined key categories of active technology such as semantic information processing, pattern recognition, and adaptation. We conducted the literature search using keywords derived from the categories and included studies that indicated a significant role for an active technology in health-related behavior change. In the data extraction, we looked specifically for the following technology roles: (1) dynamic adaptive tailoring of messages depending on context, (2) interactive education, (3) support for client self-monitoring of behavior change progress, and (4) novel ways in which interventions are grounded in behavior change theories using active technology. The search returned 228 potentially relevant articles, of which 41 satisfied the inclusion criteria. We found that significant research was focused on dialog systems, embodied conversational agents, and activity recognition. The most covered health topic was physical activity. The majority of the studies were early-stage research. Only 6 were randomized controlled trials, of which 4 were positive for behavior change and 5 were positive for acceptability. Empathy and relational behavior were significant research themes in dialog systems for behavior change, with

  14. Hydrogen exchange

    DEFF Research Database (Denmark)

    Jensen, Pernille Foged; Rand, Kasper Dyrberg

    2016-01-01

    Hydrogen exchange (HX) monitored by mass spectrometry (MS) is a powerful analytical method for investigation of protein conformation and dynamics. HX-MS monitors isotopic exchange of hydrogen in protein backbone amides and thus serves as a sensitive method for probing protein conformation...... and dynamics along the entire protein backbone. This chapter describes the exchange of backbone amide hydrogen which is highly quenchable as it is strongly dependent on the pH and temperature. The HX rates of backbone amide hydrogen are sensitive and very useful probes of protein conformation......, as they are distributed along the polypeptide backbone and form the fundamental hydrogen-bonding networks of basic secondary structure. The effect of pressure on HX in unstructured polypeptides (poly-dl-lysine and oxidatively unfolded ribonuclease A) and native folded proteins (lysozyme and ribonuclease A) was evaluated...

  15. 桩侧热交换能量桩技术开发及应用%Technology Development and Application of Energy Pile with Heat Exchange at the Pile Side

    Institute of Scientific and Technical Information of China (English)

    黄吉永

    2014-01-01

    Combined with the local reality of pile foundation and the exploration on energy pile technology, a new kind of energy pile technology with heat exchange at the pile side is presented. The main feature of the technology is bundling the ground source heat pump pipe to a precast pile buried underground by pile ramming and hooks traction. Engineering practice shows that the new construction technology has some advantages,including no squeezing effect, no damage to the pile, low noise, long pile controllable and with convenient heat exchange tube on setting. Among them, the heat exchange tubes laid on the pile almost have no impact on the construction of precast piles, overcoming the major obstacles at the respects of the traditional pre-energy pile in construction.%结合本地区的桩基工程实际和对能量桩技术的摸索,提出了在桩侧实现热交换的新型能量桩技术。该技术的主要特点是将地源热泵管绑扎于预制桩的桩侧,并通过桩体的下沉和挂钩的牵引埋入地下。通过对一个工程案例的总结分析,发现新型能量桩技术在施工方面具有无挤土效应、对桩无损伤、低噪声、桩长可控、热交换管设置方便等优点。其中,热交换管的布设对预制桩的接桩几乎无影响,克服了传统预制能量桩在施工方面的主要障碍。

  16. Overview of the Shell and Tube Heat Exchangers about Heat Transfer Enhancement Technology%管壳式换热器强化传热技术概述

    Institute of Scientific and Technical Information of China (English)

    齐洪洋; 高磊; 张莹莹; 周辰琳

    2012-01-01

    The research progress of shell and tube heat exchanger were summarized. The development, structural improvement and heat transfer enhancement of the heat exchangers were introduced through three aspects,e. g. tube pass,shell pass and the whole tub bundle etc. Compared with the traditional seg-mental baffle heat exchanger, various types of heat exchangers' characteristics about heat transfer enhancement were epitomized. At last,the studying directions of heat exchangers were pointed out.%总结了近年来国内外新型管壳式换热器的研究进展,从管程、壳程、管束三方面介绍了管壳式换热器的发展历程、结构改进及强化传热机理,并与普通弓形折流板换热器进行对比,概括了各式换热器的强化传热特点.最后指出了换热器的研究方向.

  17. Two G protein-coupled receptors activate Na+/H+ exchanger isoform 1 in Chinese hamster lung fibroblasts through an ERK-dependent pathway.

    Science.gov (United States)

    Wallert, M A; Thronson, H L; Korpi, N L; Olmschenk, S M; McCoy, A C; Funfar, M R; Provost, J J

    2005-02-01

    The sodium hydrogen exchanger isoform 1 (NHE1) is present in nearly all cells. Regulation of proton flux via the exchanger is a permissive step in cell growth and tumorgenesis and is vital in control of cell volume. The regulation of NHE1 by growth factors involves the Ras-extracellular signal regulated kinase (ERK) pathway, however, the mechanism for G protein-coupled receptor (GPCR) activation of NHE1 is not well established. In this report, the relationship between GPCRs, ERK, and NHE1 in CCL39 cells is investigated. We give evidence that two agonists, the specific alpha(1)-adrenergic agonist, phenylephrine and the water-soluble lipid mitogen, lysophosphatidic acid (LPA) activate NHE1 in CCL39 cells. Activation of ERK by phenylephrine and LPA occurs in a dose- and time-dependent manner. Optimal ERK activation was observed at 10 min and displayed a maximum stimulation at 100 microM phenylephrine and 10 microM LPA. alpha(1)-Adrenergic stimulation also led to a rise in steady-state pH(i) of 0.16+/-0.02 pH units, and incubation with LPA induced a 0.43+/-0.06 pH unit increase in pH(i). Phenylephrine-induced activation of NHE1 transport and ERK activity was inhibited by pretreating the cells with the MEK inhibitor PD98059. While only half of the LPA activatable exchange activity was abolished by PD98059 and U0126. To further demonstrate the specificity of the phenylephrine and LPA regulation of NHE1 and ERK, CCL39 cells were transfected with a kinase inactive MEK. The data indicate that ERK activation is essential for phenylephrine stimulation of NHE1, and that ERK and RhoA are involved in LPA stimulation of NHE1 by more than one mechanism. In addition, evidence of the convergence of these two pathways is shown by the loss of NHE1 activity when both pathways are inhibited and by the partial additivity of the two agonists on ERK and NHE1 activity. These studies indicate a direct involvement of ERK in the alpha(1)-adrenergic activation of NHE1 and a significant role for

  18. Current Research Activities in Drive System Technology in Support of the NASA Rotorcraft Program

    Science.gov (United States)

    Handschuh, Robert F.; Zakrajsek, James J.

    2006-01-01

    Drive system technology is a key area for improving rotorcraft performance, noise/vibration reduction, and reducing operational and manufacturing costs. An overview of current research areas that support the NASA Rotorcraft Program will be provided. Work in drive system technology is mainly focused within three research areas: advanced components, thermal behavior/emergency lubrication system operation, and diagnostics/prognostics (also known as Health and Usage Monitoring Systems (HUMS)). Current research activities in each of these activities will be presented. Also, an overview of the conceptual drive system requirements and possible arrangements for the Heavy Lift Rotorcraft program will be reviewed.

  19. FY 2000 international exchange project on exchanges of engineers - Coal mine technology field. Workshop in Japan; 2000 nendo gijutsusha koryu jigyo (tanko gijutsu bun'ya). Kokusai koryu jigyo (kokunai workshop)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    For the purpose of surveying a possibility of transfer of Japanese technology and strengthening the engineer sending project and engineer receiving/training project, Asia/Pacific Coal Workshop was held in Tokyo on November 29 and 30, 2000. On the 1st day, 9 persons including 5 from overseas and 4 from Japan gave lectures on coal production technology. On the 2nd day, after the session on safety, a panel discussion titled 'How to handle global environmental problems' was made. The lectures given were 'Development of coal resource and technical innovation,' and 'Heightening of production technology and utilization of unused resource.' The titles of the engineers invited from overseas were as follows: Trend of resource assessment/exploration technology in Australia and the subjects; Trend of resource assessment/exploration technology in Russia and the subjects; Auger coal mining - new coal mining system and possibility in the U.S. market; Successful restructure in the coal industry of Germany by technology improvement in long-wall mining/transportation/infrastructure; Present situation and future outlook of Indonesian low-ash/low-sulfur coal. (NEDO)

  20. Technology.

    Science.gov (United States)

    Online-Offline, 1998

    1998-01-01

    Focuses on technology, on advances in such areas as aeronautics, electronics, physics, the space sciences, as well as computers and the attendant progress in medicine, robotics, and artificial intelligence. Describes educational resources for elementary and middle school students, including Web sites, CD-ROMs and software, videotapes, books,…

  1. [Modulation of Na+,K+-pump activity and Na+,Li+-exchange in rabbit erythrocytes at various stages of cholesterol feeding].

    Science.gov (United States)

    Makarov, V L

    1995-09-01

    The activities of the Na+,K(+)-pump and the Na+/Li(+)-exchange and the intracellular concentration of Na+ in erythrocytes of rabbits with experimental hypercholesterolemia have been studied at different stages of cholesterol (Ch) feeding as well as at different intervals after stopping of cholesterol-rich diets. After sufficiently long periods of feeding the animals with Ch (1.5-2 months), a significant activation of the Na+,K(+)-pump, reduction of the Na+/Li(+)-exchange rate and lowering of the intracellular sodium content in erythrocytes of rabbits from experimental groups were observed. Several months after stopping Ch-rich diets there was a partial normalization of the parameters under study. However, at the initial stage of the experiment (20 days after the beginning of Ch feeding) as well as two weeks after Ch feeding had been stopped, there occurred no changes in the activities of the ion transport systems or in [Na+]i despite substantial changes in the plasma Ch level. It is suggested that the observed effect of dietary Ch on the activity of ion carriers may be mediated by affecting the expression of the corresponding genes.

  2. Technology Development of the New Efficient Heat Exchanger at Home and Aboard%国内外新型高效换热器

    Institute of Scientific and Technical Information of China (English)

    马晓驰

    2001-01-01

    Recent progress of heat exchanger at home and abroad in recent years is outlined.Methods of enhancing the heat transfer in heat exchanger about the shell and tube sides are introduced and commented.%简述了国内外近年来换热器的发展概况。介绍了管壳式换热器中管程、壳程的强化传热研究以及国内外推出的各种新型换热器的有关情况。

  3. ACTIVATED SLUDGE TECHNOLOGY COMBINED WITH HYDROPONIC LAGOON AS A TECHNOLOGY SUITABLE FOR TREATMENT OF WASTEWATER DELIVERED BY SLURRY TANKS

    Directory of Open Access Journals (Sweden)

    Aleksandra Bawiec

    2017-03-01

    Full Text Available The paper presents information related to the use of hydrophytic technology combined with traditional activated sludge solution for wastewater treatment in areas without central sewage system. The analyzed wastewater treatment plant (WWTP was operated in activated sludge technology with hybrid activated sludge reactor where biomass is kept in settled and suspended form. Treatment system was completed with hydroponic lagoon. Hydroponic lagoon has been used as tertiary treatment, in which the self-cleaning processes with the participation of the plant has come to an additional reduction of nutrients. Analyzed three stage treatment plant is located in the municipality of Nowa Sól. Only domestic wastewater delivered by slurry tanks are treated there in amount of 60 m3/d. During the observation high average concentrations of total nitrogen (201.0 mgN/dm3 was observed and organic matter expressed by COD reaching 1341.5 mgO2/dm3 and BOD5 on the level of 246.3 mgO2/dm3 were noted. A characteristic feature of an object designed for wastewater treatment delivered by slurry tanks is high irregularity of wastewater supply and high instantaneous loads of pollutants (the system does not provide expansion tank. The biggest inequality factor of the flow to the reactor was observed in December 2014 (Nd=3.9. During the observations also occurred days with no inflow of sewage. The study shows the dynamics of changes in the amount of delivered domestic wastewater and sewage flowing out of treatment plant including inequality factor. Information about quality of wastewater was used to determine the reduction of concentrations of pollutants like organic matter, suspended solids, nitrogen and phosphorus.

  4. Recommendations for Technology Development and Validation Activities in Support of the Origins Program

    Science.gov (United States)

    Capps, Richard W. (Editor)

    1996-01-01

    The Office of Space Science (OSS) has initiated mission concept studies and associated technology roadmapping activities for future large space optical systems. The scientific motivation for these systems is the study of the origins of galaxies, stars, planetary systems and, ultimately, life. Collectively, these studies are part of the 'Astronomical Search for Origins and Planetary Systems Program' or 'Origins Program'. A series of at least three science missions and associated technology validation flights is currently envisioned in the time frame between the year 1999 and approximately 2020. These would be the Space Interferometry Mission (SIM), a 10-meter baseline Michelson stellar interferometer; the Next Generation Space Telescope (NGST), a space-based infrared optimized telescope with aperture diameter larger than four meters; and the Terrestrial Planet Finder (TPF), an 80-meter baseline-nulling Michelson interferometer described in the Exploration of Neighboring Planetary Systems (ExNPS) Study. While all of these missions include significant technological challenges, preliminary studies indicate that the technological requirements are achievable. However, immediate and aggressive technology development is needed. The Office of Space Access and Technology (OSAT) is the primary sponsor of NASA-unique technology for missions such as the Origins series. For some time, the OSAT Space Technology Program has been developing technologies for large space optical systems, including both interferometers and large-aperture telescopes. In addition, technology investments have been made by other NASA programs, including OSS; other government agencies, particularly the Department of Defense; and by the aerospace industrial community. This basis of prior technology investment provides much of the rationale for confidence in the feasibility of the advanced Origins missions. In response to the enhanced interest of both the user community and senior NASA management in large

  5. Exchange Options

    NARCIS (Netherlands)

    Jamshidian, Farshid

    2007-01-01

    The contract is described and market examples given. Essential theoretical developments are introduced and cited chronologically. The principles and techniques of hedging and unique pricing are illustrated for the two simplest nontrivial examples: the classical Black-Scholes/Merton/Margrabe exchange

  6. International Exchanges

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    <正>On April 1st,2014,CPAPD Deputy Secretary General Ms.Chen Huaifan met with Mr.Djudjuk Juyoto Suntani,President of the World Peace Committee,Indonesia,who headed the delegation,in the CPAPD office.The two sides exchanged views on issues of common concern including cooperation between the two organizations and the inheritance of Chinese culture.

  7. Exchange Options

    NARCIS (Netherlands)

    Jamshidian, F.

    2007-01-01

    The contract is described and market examples given. Essential theoretical developments are introduced and cited chronologically. The principles and techniques of hedging and unique pricing are illustrated for the two simplest nontrivial examples: the classical Black-Scholes/Merton/Margrabe exchange

  8. Mammalian Mon2/Ysl2 regulates endosome-to-Golgi trafficking but possesses no guanine nucleotide exchange activity toward Arl1 GTPase

    Science.gov (United States)

    Mahajan, Divyanshu; Boh, Boon Kim; Zhou, Yan; Chen, Li; Cornvik, Tobias Carl; Hong, Wanjin; Lu, Lei

    2013-11-01

    Arl1 is a member of Arf family small GTPases that is essential for the organization and function of Golgi complex. Mon2/Ysl2, which shares significant homology with Sec7 family Arf guanine nucleotide exchange factors, was poorly characterized in mammalian cells. Here, we report the first in depth characterization of mammalian Mon2. We found that Mon2 localized to trans-Golgi network which was dependent on both its N and C termini. The depletion of Mon2 did not affect the Golgi localized or cellular active form of Arl1. Furthermore, our in vitro assay demonstrated that recombinant Mon2 did not promote guanine nucleotide exchange of Arl1. Therefore, our results suggest that Mon2 could be neither necessary nor sufficient for the guanine nucleotide exchange of Arl1. We demonstrated that Mon2 was involved in endosome-to-Golgi trafficking as its depletion accelerated the delivery of furin and CI-M6PR to Golgi after endocytosis.

  9. Local correlations for flap gap oscillatory blowing active flow control technology

    Directory of Open Access Journals (Sweden)

    Cătălin NAE

    2010-09-01

    Full Text Available Active technology for oscillatory blowing in the flap gap has been tested at INCAS subsonic wind tunnel in order to evaluate this technology for usage in high lift systems with active flow control. The main goal for this investigation was to validate TRL level 4 for this technology and to extend towards flight testing. CFD analysis was performed in order to identify local correlations with experimental data and to better formulate a design criteria so that a maximum increase in lift is possible under given geometrical constraints. Reference to a proposed metric for noise evaluation is also given. This includes basic 2D flow cases and also 2.5D configurations. In 2.5D test cases this work has been extended so that the proposed system may be selected as a mature technology in the JTI Clean Sky, Smart Fixed Wing Aircraft ITD. Complex post-processing of the experimental and CFD data was mainly oriented towards system efficiency and TRL evaluation for this active technology.

  10. eHealth technologies to support nutrition and physical activity behaviors in diabetes self-management.

    Science.gov (United States)

    Rollo, Megan E; Aguiar, Elroy J; Williams, Rebecca L; Wynne, Katie; Kriss, Michelle; Callister, Robin; Collins, Clare E

    2016-01-01

    Diabetes is a chronic, complex condition requiring sound knowledge and self-management skills to optimize glycemic control and health outcomes. Dietary intake and physical activity are key diabetes self-management (DSM) behaviors that require tailored education and support. Electronic health (eHealth) technologies have a demonstrated potential for assisting individuals with DSM behaviors. This review provides examples of technologies used to support nutrition and physical activity behaviors in the context of DSM. Technologies covered include those widely used for DSM, such as web-based programs and mobile phone and smartphone applications. In addition, examples of novel tools such as virtual and augmented reality, video games, computer vision for dietary carbohydrate monitoring, and wearable devices are provided. The challenges to, and facilitators for, the use of eHealth technologies in DSM are discussed. Strategies to support the implementation of eHealth technologies within practice and suggestions for future research to enhance nutrition and physical activity behaviors as a part of broader DSM are provided.

  11. eHealth technologies to support nutrition and physical activity behaviors in diabetes self-management

    Science.gov (United States)

    Rollo, Megan E; Aguiar, Elroy J; Williams, Rebecca L; Wynne, Katie; Kriss, Michelle; Callister, Robin; Collins, Clare E

    2016-01-01

    Diabetes is a chronic, complex condition requiring sound knowledge and self-management skills to optimize glycemic control and health outcomes. Dietary intake and physical activity are key diabetes self-management (DSM) behaviors that require tailored education and support. Electronic health (eHealth) technologies have a demonstrated potential for assisting individuals with DSM behaviors. This review provides examples of technologies used to support nutrition and physical activity behaviors in the context of DSM. Technologies covered include those widely used for DSM, such as web-based programs and mobile phone and smartphone applications. In addition, examples of novel tools such as virtual and augmented reality, video games, computer vision for dietary carbohydrate monitoring, and wearable devices are provided. The challenges to, and facilitators for, the use of eHealth technologies in DSM are discussed. Strategies to support the implementation of eHealth technologies within practice and suggestions for future research to enhance nutrition and physical activity behaviors as a part of broader DSM are provided. PMID:27853384

  12. Driving technology for improving motion quality of active-matrix organic light-emitting diode display

    Science.gov (United States)

    Kim, Jongbin; Kim, Minkoo; Kim, Jong-Man; Kim, Seung-Ryeol; Lee, Seung-Woo

    2014-09-01

    This paper reports transient response characteristics of active-matrix organic light emitting diode (AMOLED) displays for mobile applications. This work reports that the rising responses look like saw-tooth waveform and are not always faster than those of liquid crystal displays. Thus, a driving technology is proposed to improve the rising transient responses of AMOLED based on the overdrive (OD) technology. We modified the OD technology by combining it with a dithering method because the conventional OD method cannot successfully enhance all the rising responses. Our method can improve all the transitions of AMOLED without modifying the conventional gamma architecture of drivers. A new artifact is found when OD is applied to certain transitions. We propose an optimum OD selection method to mitigate the artifact. The implementation results show the proposed technology can successfully improve motion quality of scrolling texts as well as moving pictures in AMOLED displays.

  13. Business cycle and innovation activity in medium-high and high technology industry in Poland

    Directory of Open Access Journals (Sweden)

    Dzikowski Piotr

    2015-12-01

    Full Text Available This article examines differences in an impact of business cycle phases on innovation activity in medium-high and high technology industry in Poland. It is assumed that each business cycle phase influences innovation activity in the same fashion, but its impact varies and it depends on the firm’s innovation activity. The higher innovation activity the less impact of business cycle. The scope of the survey relates to innovation in MHT and HT industry in Poland. The data concerns the innovation at the firm level and the diffusion “new for the company”. Innovation activity is defined by the following activities: (1 expenditure on research and development and investments in fixed assets not used so far such as: abuildings, premises and land; b machinery and equipment, c computer software; (2 implementation of new products and technological processes and (3 innovation cooperation. The methodological part of the analysis includes a logit modeling. The survey includes 1355 companies. Business cycle has a great influence on innovation activity in MTH and HT industry in Poland. The influence of recovery phase is positive whereas both stagnation and recession phases decrease the probability of innovation activity. The character of influence depends on the propensity to take innovation activity. The higher level of innovation activity the enterprises present the less influence of business cycle they get.

  14. [Effects of ginkgo diterpene lactones meglumine injection's activated carbon adsorption technology on officinal components].

    Science.gov (United States)

    Zhou, En-li; Wang, Ren-jie; Li, Miao; Wang, Wei; Xu, Dian-hong; Hu, Yang; Wang, Zhen-zhong; Bi, Yu-an; Xiao, Wei

    2015-10-01

    With the diversion rate of ginkgolide A, B, K as comprehensive evaluation indexes, the amount of activated carbon, ad- sorption time, mix rate, and adsorption temperature were selected as factors, orthogonal design which based on the evaluation method of information entropy was used to optimize activated carbon adsorption technology of ginkgo diterpene lactones meglumine injection. Opti- mized adsorption conditions were as follows: adsorbed 30 min with 0.2% activated carbon in 25 °C, 40 r ·min⁻¹, validation test re- sult display. The optimum extraction condition was stable and feasible, it will provide a basis for ginkgo diterpene lactone meglumine injection' activated carbon adsorption process.

  15. Future role and significance of space activities in reflection of global social, technological and economic trends

    Science.gov (United States)

    Diekmann, Andreas; Richarz, Hans.-Peter

    The paper describes the interrelation of space activities and global socio-economic trends like "globalisation of markets" and "renaissance of fine arts". The interrelation reveals the economic strategic, technological and scientific dimension of space activities and their benefits to mankind. Then, the significance and perspectives of space activities in these dimensions are examined in more detail. The paper calls (1) for a more visible initiative to employ space activities to tackle urgent questions of global change and development, and (2) for a stronger impetus to secure European economic position in space sector as a key industry of the 21st century.

  16. An Introduction to CRISPR Technology for Genome Activation and Repression in Mammalian Cells.

    Science.gov (United States)

    Du, Dan; Qi, Lei S

    2016-01-04

    CRISPR interference/activation (CRISPRi/a) technology provides a simple and efficient approach for targeted repression or activation of gene expression in the mammalian genome. It is highly flexible and programmable, using an RNA-guided nuclease-deficient Cas9 (dCas9) protein fused with transcriptional regulators for targeting specific genes to effect their regulation. Multiple studies have shown how this method is an effective way to achieve efficient and specific transcriptional repression or activation of single or multiple genes. Sustained transcriptional modulation can be obtained by stable expression of CRISPR components, which enables directed reprogramming of cell fate. Here, we introduce the basics of CRISPRi/a technology for genome repression or activation.

  17. 基于VPN网络技术的无人值守换热站监控系统%Unmanned Heat Exchanger Station Monitoring System Based on VPN Network Technology

    Institute of Scientific and Technical Information of China (English)

    韩松林

    2011-01-01

    随着计算机技术和通讯技术发展和应用,企业信息化已经成为企业实现可持续发展和提高市场竞争力的重要保障。介绍了基于VPN的无人值守换热站监控系统的组成、功能及实现方法。数据监控中心上位机采用组态王软件和远程站点PLC通过VPN专网相连接,组成一个封闭的无人值守站监控系统。基于VPN网络的无人值守换热站监控系统体现了信息化在城市供热行业中的应用。%With the computer technology and communication technology development and application of information technology has become a business enterprise to achieve sustainable development and improve market competitiveness is an important guarantee.Describes the VPN-based unmanned station monitoring system heat exchanger composition, function and implementation.Data Monitoring Center PC with remote sites,and Configuration software PLC connected through the VPN special network, form a closed unmanned station monitoring system.VPN-based network monitoring system unattended heat exchange station in the city reflects the information in the application of the heating industry.

  18. eHealth technologies to support nutrition and physical activity behaviors in diabetes self-management

    Directory of Open Access Journals (Sweden)

    Rollo ME

    2016-11-01

    Full Text Available Megan E Rollo,1 Elroy J Aguiar,2 Rebecca L Williams,1 Katie Wynne,3 Michelle Kriss,3 Robin Callister,4 Clare E Collins1 1School of Health Sciences, Faculty of Health and Medicine, Priority Research Centre for Physical Activity and Nutrition, University of Newcastle, Callaghan, NSW, Australia; 2Department of Kinesiology, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, MA, USA; 3Department of Diabetes and Endocrinology, John Hunter Hospital, Hunter New England Health, New Lambton, NSW, Australia;\t4School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, Priority Research Centre for Physical Activity and Nutrition, University of Newcastle, Callaghan, NSW, Australia Abstract: Diabetes is a chronic, complex condition requiring sound knowledge and self-management skills to optimize glycemic control and health outcomes. Dietary intake and physical activity are key diabetes self-management (DSM behaviors that require tailored education and support. Electronic health (eHealth technologies have a demonstrated potential for assisting individuals with DSM behaviors. This review provides examples of technologies used to support nutrition and physical activity behaviors in the context of DSM. Technologies covered include those widely used for DSM, such as web-based programs and mobile phone and smartphone applications. In addition, examples of novel tools such as virtual and augmented reality, video games, computer vision for dietary carbohydrate monitoring, and wearable devices are provided. The challenges to, and facilitators for, the use of eHealth technologies in DSM are discussed. Strategies to support the implementation of eHealth technologies within practice and suggestions for future research to enhance nutrition and physical activity behaviors as a part of broader DSM are provided. Keywords: diabetes self-management, eHealth, nutrition, physical activity, smartphones, wearables

  19. Thermal Technology Development Activities at the Goddard Space Flight Center - 2001

    Science.gov (United States)

    Butler, Dan

    2002-01-01

    This presentation provides an overview of thermal technology development activities carried out at NASA's Goddard Space Flight Center during 2001. Specific topics covered include: two-phase systems (heat pipes, capillary pumped loops, vapor compression systems and phase change materials), variable emittance systems, advanced coatings, high conductivity materials and electrohydrodynamic (EHD) thermal coatings. The application of these activities to specific space missions is also discussed.

  20. Tasks and activities to enhance technological Pedagogical Mathematical Content Knowledge of teachers

    OpenAIRE

    Powell, Arthur B.

    2016-01-01

    From a sociocultural perspective, we examine activities generated by genres of tasks to understand how the tasks shape teachers knowledge of technology and mathematical content for teaching. The tasks and activities come from a professional development project that engages the cyberlearning system, Virtual Math Teams with GeoGebra. Working in teams, teachers enhance their understanding of dynamic geometry and how to engage in productive mathematical discussion. We theorize and discuss princip...

  1. Heat exchanger leakage problem location

    Directory of Open Access Journals (Sweden)

    Jícha Miroslav

    2012-04-01

    Full Text Available Recent compact heat exchangers are very often assembled from numerous parts joined together to separate heat transfer fluids and to form the required heat exchanger arrangement. Therefore, the leak tightness is very important property of the compact heat exchangers. Although, the compact heat exchangers have been produced for many years, there are still technological problems associated with manufacturing of the ideal connection between the individual parts, mainly encountered with special purpose heat exchangers, e.g. gas turbine recuperators. This paper describes a procedure used to identify the leakage location inside the prime surface gas turbine recuperator. For this purpose, an analytical model of the leaky gas turbine recuperator was created to assess its performance. The results obtained are compared with the experimental data which were acquired during the recuperator thermal performance analysis. The differences between these two data sets are used to indicate possible leakage areas.

  2. Heat exchanger leakage problem location

    Science.gov (United States)

    Hejčík, Jiří; Jícha, Miroslav

    2012-04-01

    Recent compact heat exchangers are very often assembled from numerous parts joined together to separate heat transfer fluids and to form the required heat exchanger arrangement. Therefore, the leak tightness is very important property of the compact heat exchangers. Although, the compact heat exchangers have been produced for many years, there are still technological problems associated with manufacturing of the ideal connection between the individual parts, mainly encountered with special purpose heat exchangers, e.g. gas turbine recuperators. This paper describes a procedure used to identify the leakage location inside the prime surface gas turbine recuperator. For this purpose, an analytical model of the leaky gas turbine recuperator was created to assess its performance. The results obtained are compared with the experimental data which were acquired during the recuperator thermal performance analysis. The differences between these two data sets are used to indicate possible leakage areas.

  3. THE EXPERIMENTAL PLAN OF THE DEVELOPMENT OF STUDENTS’ COGNITIVE ACTIVITY BY MEANS OF THE REFLECTIVE TECHNOLOGY

    Directory of Open Access Journals (Sweden)

    D. I. Gasanova

    2016-01-01

    Full Text Available Considering the problem of the cognitive activity development is extremely topical, the author of the article represents the concrete experimental plan for the development of the students’ cognitive activity by means of the reflective technology. In the author's opinion, the reflection increases the cognitive activity, by virtue of giving the process of learning the subjectness and subjectivity features (the subjectness of the cognition reflects the individual's activity, while the subjectivity reflects the personal meaning of the content of the cognition and the cognitive process. The aim of the paper is studying the possibilities of the reflective technology in enhancing the students’ cognitive activity. The object of the study is the cognitive activity of the cognition subjects. The subject of the research is the reflexive educational technologies as a means of developing the cognition subjects’ cognitive activity. At an ascertaining stage the author diagnosed the cognitive activity peculiarities, expressed in the academic success indicators, the degree of the learning difficulty/easiness, the emotional attitude towards the learning (like/doesn’t like to learn, curiosity, the internality of achievements and students’ reflection in the experimental and the control groups. At a forming stage of the research the author approved the reflective technology of increasing the students’ cognitive activity in the experimental groups. At a control stage she performed the repeated diagnostics of the cognitive activity peculiarities, expressed in the academic success indicators and future teachers’ reflection in the experimental and control groups. As a result of the experiment, which lasted during 2 semesters the students’ reflexivity of thinking became significantly increased, their reflective skills were developed, and the need for self-cognition and development appeared. Their cognitive activity was substantially increased, expressed

  4. Research and technology activities at Ames Research Center's Biomedical Research Division

    Science.gov (United States)

    Martello, N.

    1985-01-01

    Various research and technology activities at Ames Research Center's Biomedical Research Division are described. Contributions to the Space Administration's goals in the life sciences include descriptions of research in operational medicine, cardiovascular deconditioning, motion sickness, bone alterations, muscle atrophy, fluid and electrolyte changes, radiation effects and protection, behavior and performance, gravitational biology, and life sciences flight experiments.

  5. Evaluation methods for physical activity-promoting mobile technologies: an interdisciplinary scoping review

    Directory of Open Access Journals (Sweden)

    Claire McCallum

    2015-10-01

    Full Text Available There are many thousands of mobile apps, wearables and other technologies available to support and promote physical activity. However, the rapidly evolving nature of these technologies means that the methodologies traditionally used to evaluate the effectiveness of behaviour change interventions (such as the randomised controlled trial may not be appropriate to evaluate their effectiveness. A scoping review was conducted to identify the methods currently being used to evaluate physical activity-promoting mobile technologies across health and computing science disciplines. In addition to the range of methods used, the review explored their strengths and weaknesses. The results improve understandings of when and why to use existing methods from health and computing science. Opportunities for combining and hybridising methods across the two disciplines are also identified. The review will be used to inform the development and piloting of novel, ‘fit-for-purpose’ research designs that will allow rigorous evaluation of the effectiveness of rapidly-evolving physical activity-promoting mobile technologies and their ‘active ingredients’ to build an evidence base of what works, why and for whom.

  6. Interactive Whiteboards and All That Jazz: Analysing Classroom Activity with Interactive Technologies

    Science.gov (United States)

    Tanner, Howard; Beauchamp, Gary; Jones, Sonia; Kennewell, Steve

    2010-01-01

    The term "orchestration", has been used to describe the teacher's role in activity settings incorporating interactive technologies. This musical analogy suggests pre-planned manipulation of events to generate "performance" leading to learning. However, in two recent projects we have observed how effective teaching and learning…

  7. Technological and Traditional Drawing Approaches Encourage Active Engagement in Histology Classes for Science Undergraduates

    Science.gov (United States)

    Cogdell, Barbara; Torsney, Ben; Stewart, Katherine; Smith, Robert A.

    2012-01-01

    In order to promote more active engagement of science undergraduates in histology practical classes some technology-based innovations were introduced. First, an interactive pre-lab tutorial was set up using an electronic handset voting system, where guidance on tissue analysis was given. Second, a web-based resource where students could access…

  8. Pre-Service Teachers' Learning Styles and Preferences towards Instructional Technology Activities and Collaborative Works

    Science.gov (United States)

    Yusop, Farrah Dina; Sumari, Melati

    2015-01-01

    The main purpose of this exploratory study was to investigate pre-service teachers' learning styles and their preferences with respect to 15 technology-based instructional activities and collaborative work tasks. Felder and Silverman's online Index of Learning Style (ILS) and a questionnaire were used to measure students' learning styles and…

  9. Overview of CERN Technology Transfer Strategy and Accelerator-Related Activities

    CERN Document Server

    Chesta, E; Wuensch, W; Sgobba, S; Stora, T; Chiggiato, P; Taborelli, M

    2013-01-01

    CERN, the European Organization for Nuclear Research, is actively engaged in identifying technologies developed for its accelerator complex that could be profitably used by partner research organizations or commercial companies in applications with potentially high socio-economic impact beyond pure fundamental physics research. \

  10. Teacher roles in designing technology-rich learning activities for early literacy

    NARCIS (Netherlands)

    Cviko, Amina; McKenney, Susan; Voogt, Joke

    2015-01-01

    The present study aims to provide insight into the value of different teacher roles in designing and implementing technology-rich learning activities for early literacy. Three cases, each with a different teacher role (executor-only, re-designer, co-designer) were examined. In the executor-only

  11. Teachers conversations during design of technology rich curriculum activities for early literacy

    NARCIS (Netherlands)

    Boschman, Ferry; McKenney, Susan; Voogt, Joke

    2014-01-01

    Boschman, F., McKenney, S. & Voogt (2013). Teachers conversations during design of technology rich curriculum activities for early literacy. Paper presentation at the European Association for Practitioner Research on Improving Learning (EAPRIL) Annual Conference. November 27-29, Biel/Bienne, Switzer

  12. 77 FR 42949 - Special Conditions: Tamarack Aerospace Group, Cirrus Model SR22; Active Technology Load...

    Science.gov (United States)

    2012-07-23

    ..., four-passenger, composite airplane. The installation of winglets, as proposed by Tamarack, increases... design change will install winglets and an Active Technology Load Alleviation system (ATLAS). The addition of the ATLAS mitigates the negative effects of the winglets by effectively aerodynamically...

  13. 77 FR 28530 - Special Conditions: Tamarack Aerospace Group, Cirrus Model SR22; Active Technology Load...

    Science.gov (United States)

    2012-05-15

    ..., composite airplane. The installation of winglets, as proposed by Tamarack, increases aerodynamic efficiency... Group's modification. The design change will install winglets and an Active Technology Load Alleviation System (ATLAS). The addition of the ATLAS mitigates the negative effects of the winglets by...

  14. 78 FR 10055 - Special Conditions: Tamarack Aerospace Group, Cirrus Model SR22; Active Technology Load...

    Science.gov (United States)

    2013-02-13

    ... engine, four- passenger, composite airplane. The installation of winglets, as proposed by Tamarack... Aerospace Group's modification. The design change will install winglets and an Active Technology Load Alleviation System (ATLAS). The addition of the ATLAS mitigates the negative effects of the winglets...

  15. Physics Education Technology (PhET) Virtual Lab Activities for Distance Learning Courses

    Science.gov (United States)

    Callaway, Thomas

    2012-03-01

    The Physics Education Technology (PhET) simulations offer a great set of tools to present simulations of physics phenomena in the classroom. This presentation describes the use of PhET to develop virtual lab assignments that supplement hands-on lab activities for a distance learning class in conceptual physics.

  16. Tailored interventions to promote Active Ageing using mobile technology: a feasibility study

    NARCIS (Netherlands)

    Cabrita, M.; Melenk, J.; El Menshawy, N.; Tabak, Monique; Vollenbroek-Hutten, Miriam Marie Rosé

    2016-01-01

    Introduction: Mobile technologies facilitate innovative and ubiquitous interventions to promote Active Ageing in daily life. To ensure adoption, such interventions must be designed in co-operation with older adults. This work presents the results of a feasibility study of a system that monitors

  17. Rockets: An Educator's Guide with Activities in Science, Mathematics, and Technology.

    Science.gov (United States)

    National Aeronautics and Space Administration, Washington, DC.

    This educational guide discusses rockets and includes activities in science, mathematics, and technology. It begins with background information on the history of rocketry, scientific principles, and practical rocketry. The sections on scientific principles and practical rocketry focus on Sir Isaac Newton's Three Laws of Motion. These laws explain…

  18. Using Technology To Implement Active Learning in Large Classes. Technical Report.

    Science.gov (United States)

    Gerace, William J.; Dufresne, Robert J.; Leonard, William J.

    An emerging technology, classroom communication systems (CCSs), has the potential to transform the way we teach science in large-lecture settings. CCSs can serve as catalysts for creating a more interactive, student-centered classroom in the lecture hall, thereby allowing students to become more actively involved in constructing and using…

  19. Teacher roles in designing technology-rich learning activities for early literacy

    NARCIS (Netherlands)

    Cviko, Amina; McKenney, Susan; Voogt, Joke

    2015-01-01

    The present study aims to provide insight into the value of different teacher roles in designing and implementing technology-rich learning activities for early literacy. Three cases, each with a different teacher role (executor-only, re-designer, co-designer) were examined. In the executor-only role

  20. Technological and Traditional Drawing Approaches Encourage Active Engagement in Histology Classes for Science Undergraduates

    Science.gov (United States)

    Cogdell, Barbara; Torsney, Ben; Stewart, Katherine; Smith, Robert A.

    2012-01-01

    In order to promote more active engagement of science undergraduates in histology practical classes some technology-based innovations were introduced. First, an interactive pre-lab tutorial was set up using an electronic handset voting system, where guidance on tissue analysis was given. Second, a web-based resource where students could access…