WorldWideScience

Sample records for technology computer-aided design

  1. Technology computer aided design simulation for VLSI MOSFET

    CERN Document Server

    Sarkar, Chandan Kumar

    2013-01-01

    Responding to recent developments and a growing VLSI circuit manufacturing market, Technology Computer Aided Design: Simulation for VLSI MOSFET examines advanced MOSFET processes and devices through TCAD numerical simulations. The book provides a balanced summary of TCAD and MOSFET basic concepts, equations, physics, and new technologies related to TCAD and MOSFET. A firm grasp of these concepts allows for the design of better models, thus streamlining the design process, saving time and money. This book places emphasis on the importance of modeling and simulations of VLSI MOS transistors and

  2. Computer-aided design and computer science technology

    Science.gov (United States)

    Fulton, R. E.; Voigt, S. J.

    1976-01-01

    A description is presented of computer-aided design requirements and the resulting computer science advances needed to support aerospace design. The aerospace design environment is examined, taking into account problems of data handling and aspects of computer hardware and software. The interactive terminal is normally the primary interface between the computer system and the engineering designer. Attention is given to user aids, interactive design, interactive computations, the characteristics of design information, data management requirements, hardware advancements, and computer science developments.

  3. The application of computer-aided technologies in automotive styling design

    Science.gov (United States)

    Zheng, Ze-feng; Zhang, Ji; Zheng, Ying

    2012-04-01

    In automotive industry, outline design is its life and creative design is its soul indeed. Computer-aided technology has been widely used in the automotive industry and more and more attention has been paid. This paper chiefly introduce the application of computer-aided technologies including CAD, CAM and CAE, analyses the process of automotive structural design and describe the development tendency of computer-aided design.

  4. Retrofitting a crown to a sleep apnea device by using computer-aided design and computer-aided milling technology.

    Science.gov (United States)

    Biethman, Rick; Land, Martin F; Hruskocy, Heather; Colgin, Bruce

    2014-07-01

    Retrofitting a new crown to an existing dental device is challenging. The continued evolution of computer-aided design and computer-aided manufacturing (CAD/CAM) significantly simplifies the process. This article demonstrates retrofitting a gold crown to an existing sleep apnea device.

  5. Discuss the Development of Computer-Aided Industrial Design Technology

    Directory of Open Access Journals (Sweden)

    Jun Yao

    2013-01-01

    Full Text Available The direction of the development of the industrial design gradually approaches mechanical-electrical integration and informational and electronic products. With an increasing improvement of its technical content, and better social economic conditions, peoples consumption concept are getting more and more different. Consumer concerns not just the functionality and quality of the product, more and more people are starting to focus on the appearance of the product, degree of innovation, environmental protection, and so on, which brings a higher degree of difficulty to the industrial technology. It is because the increasing demands of people and the industrial design, many scholars are increasingly concerned about the industrial design in recent years. With the continuous development of computer technology, a wide variety of hardware and software are developed, and a variety of ever-changing technologies are attracting the industrial design talents as well.

  6. Computer aided product design

    DEFF Research Database (Denmark)

    Constantinou, Leonidas; Bagherpour, Khosrow; Gani, Rafiqul

    1996-01-01

    A general methodology for Computer Aided Product Design (CAPD) with specified property constraints which is capable of solving a large range of problems is presented. The methodology employs the group contribution approach, generates acyclic, cyclic and aromatic compounds of various degrees......-liquid equilibria (LLE), solid-liquid equilibria (SLE) and gas solubility. Finally, a computer program based on the extended methodology has been developed and the results from five case studies highlighting various features of the methodology are presented....

  7. Technology and Jobs: Computer-Aided Design. Numerical-Control Machine-Tool Operators. Office Automation.

    Science.gov (United States)

    Stanton, Michael; And Others

    1985-01-01

    Three reports on the effects of high technology on the nature of work include (1) Stanton on applications and implications of computer-aided design for engineers, drafters, and architects; (2) Nardone on the outlook and training of numerical-control machine tool operators; and (3) Austin and Drake on the future of clerical occupations in automated…

  8. Computer aided drug design

    Science.gov (United States)

    Jain, A.

    2017-08-01

    Computer based method can help in discovery of leads and can potentially eliminate chemical synthesis and screening of many irrelevant compounds, and in this way, it save time as well as cost. Molecular modeling systems are powerful tools for building, visualizing, analyzing and storing models of complex molecular structure that can help to interpretate structure activity relationship. The use of various techniques of molecular mechanics and dynamics and software in Computer aided drug design along with statistics analysis is powerful tool for the medicinal chemistry to synthesis therapeutic and effective drugs with minimum side effect.

  9. Special Technology Area Review on Computer Aided Design

    Science.gov (United States)

    1993-03-01

    develop MHDL, AHDL , etc., not only to provide a common modeling language but also to support a robust design environment. This would include language...tools are critical. Analog synthesis requirements must be reflected in VHDL and AHDL (Analog Hardware Description Language) standards. The tools should

  10. RETRACTED: Auricular prosthesis fabrication using computer-aided design and rapid prototyping technologies.

    Science.gov (United States)

    Shah, Mayank

    2016-06-01

    At the request of the editorMayank Shah 'Auricular prosthesis fabrication using computer-aided design and rapid prototyping technologies' Prosthetics and Orthotics International, published online before print on October 8, 2013 as doi:10.1177/0309364613504779has been retracted. This is because it contains unattributed overlap withK. Subburaj, C. Nair, S. Rajesh, S. M. Meshram, B. Ravi 'Rapid development of auricular prosthesis using CAD and rapid prototyping technologies' International Journal of Oral & Maxillofacial Surgery 2007; 36: 938-943 doi:10.1016/j.ijom.2007.07.013. © The International Society for Prosthetics and Orthotics 2014.

  11. Computer Aided Filter Design.

    Science.gov (United States)

    1987-12-01

    FIR filter can be described in the following. [Ref. 2] 1. FIR filters with exact linear phase can be easily designed. Linear phase filters are important...response for the four cases of linear phase filter , i.e., even or odd symmetry with an even or odd number of terms, can be written in the form: H (eJ ) = e...Ansari, The Design and Application of Optimal FIR Fractional Phase Filters , IEEE on Acoutics, Speech and Signal Processing, Vol. 2, 1987, pp.896-899. 77 14

  12. Computer Aided Design of Couplings

    OpenAIRE

    2011-01-01

    The research work explores computer-aided approach to the design of ten different couplings, viza viz: flange, solid rigid, hollow rigid, old ham/ cross-sliding, pin type flexible, sleeve, seller cone/compression, split muff, pulley flange and fairbian’s lap-box couplings. The approach utilizesstandard design equations of these couplings and link them together in computer software todetermine the design parameters of the couplings. The work reviews the procedural stepsinvolved in the design o...

  13. Computer Aided Design of Couplings

    OpenAIRE

    2011-01-01

    The research work explores computer-aided approach to the design of ten different couplings, viz a viz: flange, solid rigid, hollow rigid, old ham/ cross-sliding, pin type flexible, sleeve, seller cone/ compression, split muff, pulley flange and fairbian’s lap-box couplings. The approach utilizes standard design equations of these couplings and link them together in computer software to determine the design parameters of the couplings. The work reviews the procedural steps involved in the des...

  14. Art,Science and Technology——Computed Aided Design in Practice & How computer technology affect designer’s work

    Institute of Scientific and Technical Information of China (English)

    赵耀

    2010-01-01

    Introduction:Computing technology has developed significantly in the past few decades.It affects almost everyone in the modern society,creating new ways of communication which affects both our work and leisure activities.Particularly,in today’s world of design and technology,computer aided design is fast becoming a technologically and economically feasible reality.Most designers have accepted the fact that computer aided design plays an important role in the success of their practices,not due to it’s value as an efficient drafting and modeling tool,but also because of clients’perception that it makes sound financial sense to utilize CAD.On the other hand,many people argue that computers are not fully autonomous,they are merely unconscious digital slaves or tools of production.In addition,the abusive use of software technology would turn creative art design into a purely industrial activity.

  15. Mirror-image anterior crown fabrication with computer-aided design and rapid prototyping technology: a clinical report.

    Science.gov (United States)

    Cho, Seok-Hwan; Chang, Won-Gun

    2013-02-01

    This clinical report describes the fabrication of a maxillary central incisor single crown with rapid prototyping (RP) technology. A patient with a recently replaced metal ceramic crown had discomfort due to the nonanatomic lingual contour of the crown. With computer-aided design (CAD) software and rapid prototyping (RP) technology, the shape of the contralateral central incisor was duplicated and reproduced to make a mirror-image for a new crown. The prosthodontic planning and treatment approach are discussed.

  16. Computer-aided system design

    Science.gov (United States)

    Walker, Carrie K.

    1991-01-01

    A technique has been developed for combining features of a systems architecture design and assessment tool and a software development tool. This technique reduces simulation development time and expands simulation detail. The Architecture Design and Assessment System (ADAS), developed at the Research Triangle Institute, is a set of computer-assisted engineering tools for the design and analysis of computer systems. The ADAS system is based on directed graph concepts and supports the synthesis and analysis of software algorithms mapped to candidate hardware implementations. Greater simulation detail is provided by the ADAS functional simulator. With the functional simulator, programs written in either Ada or C can be used to provide a detailed description of graph nodes. A Computer-Aided Software Engineering tool developed at the Charles Stark Draper Laboratory (CSDL CASE) automatically generates Ada or C code from engineering block diagram specifications designed with an interactive graphical interface. A technique to use the tools together has been developed, which further automates the design process.

  17. Computer Aided Design in Engineering Education.

    Science.gov (United States)

    Gobin, R.

    1986-01-01

    Discusses the use of Computer Aided Design (CAD) and Computer Aided Manufacturing (CAM) systems in an undergraduate engineering education program. Provides a rationale for CAD/CAM use in the already existing engineering program. Describes the methods used in choosing the systems, some initial results, and warnings for first-time users. (TW)

  18. ICAM (Integrated Computer-Aided Manufacturing) Manufacturing Cost/Design Guide. Volume 7. Technology Transfer Summary.

    Science.gov (United States)

    1984-09-01

    advanced composite structures for production. Conduct material and manufacturing trade-off studies on ATF advanced design, NASA composite wing, and...255-7371. D-17 .* . . . . . . .. . .. .. . . . . . - . , o , . . - .’. TTD4502 60000 12 Sept 1984 CC tE % > LL 00 o0h K; Cr A .’ TTD450260000 12... coatings on the internal "Top-of-the-Line" Manu- observing the effect of the surfaces of hollowf~acturing Technology Success proposed change. Potential

  19. Computer Aided Drug Design: Success and Limitations.

    Science.gov (United States)

    Baig, Mohammad Hassan; Ahmad, Khurshid; Roy, Sudeep; Ashraf, Jalaluddin Mohammad; Adil, Mohd; Siddiqui, Mohammad Haris; Khan, Saif; Kamal, Mohammad Amjad; Provazník, Ivo; Choi, Inho

    2016-01-01

    Over the last few decades, computer-aided drug design has emerged as a powerful technique playing a crucial role in the development of new drug molecules. Structure-based drug design and ligand-based drug design are two methods commonly used in computer-aided drug design. In this article, we discuss the theory behind both methods, as well as their successful applications and limitations. To accomplish this, we reviewed structure based and ligand based virtual screening processes. Molecular dynamics simulation, which has become one of the most influential tool for prediction of the conformation of small molecules and changes in their conformation within the biological target, has also been taken into account. Finally, we discuss the principles and concepts of molecular docking, pharmacophores and other methods used in computer-aided drug design.

  20. State-of-the-art technology in modern computer-aided drug design.

    Science.gov (United States)

    Dalkas, Georgios A; Vlachakis, Dimitrios; Tsagkrasoulis, Dimosthenis; Kastania, Anastasia; Kossida, Sophia

    2013-11-01

    The quest for small drug-like compounds that selectively inhibit the function of biological targets has always been a major focus in the pharmaceutical industry and in academia as well. High-throughput screening of compound libraries requires time, cost and resources. Therefore, the use of alternative methods is necessary for facilitating lead discovery. Computational techniques that dock small molecules into macromolecular targets and predict the affinity and activity of the small molecule are widely used in drug design and discovery, and have become an integral part of the industrial and academic research. In this review, we present an overview of some state-of-the-art technologies in modern drug design that have been developed for expediting the search for novel drug candidates.

  1. Computer Aided Control System Design (CACSD)

    Science.gov (United States)

    Stoner, Frank T.

    1993-01-01

    The design of modern aerospace systems relies on the efficient utilization of computational resources and the availability of computational tools to provide accurate system modeling. This research focuses on the development of a computer aided control system design application which provides a full range of stability analysis and control design capabilities for aerospace vehicles.

  2. Computer aided materials design; Keisanki zairyo sekkei

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    The questionnaire survey on the computer aided materials design (CAMD), and the survey of current domestic and overseas software concerned were carried out to clarify developmental issues. The current elementary technology of CAMD was also surveyed to study its several problems caused with a progress of material design technology due to drastic diffusion of CAMD. This project aims at establishment of a new demanded software, computer chemistry, focusing attention on functional materials such as catalyst, polymer and non-linear electronic materials. Microscopic simulation technology was mainly surveyed in fiscal 1996. Although some fruitful results have been obtained in the fields of medical and agricultural chemicals, organic compounds, proteins, catalysts and electronic materials, such some problems are pointed out as `CAMD cannot handle an actual size of the target system` and `commercially available software are very expensive.` Reliable tool development as elementary technology, and the verification of its applications are thus required. Meso-dynamics, polymers, surface reaction and integrated technological environment attract users` attention. 27 refs., 16 figs., 2 tabs.

  3. Interactive computer aided technology, evolution in the design/manufacturing process

    Science.gov (United States)

    English, C. H.

    1975-01-01

    A powerful computer-operated three dimensional graphic system and associated auxiliary computer equipment used in advanced design, production design, and manufacturing was described. This system has made these activities more productive than when using older and more conventional methods to design and build aerospace vehicles. With the use of this graphic system, designers are now able to define parts using a wide variety of geometric entities, define parts as fully surface 3-dimensional models as well as "wire-frame" models. Once geometrically defined, the designer is able to take section cuts of the surfaced model and automatically determine all of the section properties of the planar cut, lightpen detect all of the surface patches and automatically determine the volume and weight of the part. Further, his designs are defined mathematically at a degree of accuracy never before achievable.

  4. Technology Computer-Aided Design and Study of Prototypes of a Silicon Zener Diode

    Science.gov (United States)

    Dudar, N. L.; Borzdov, V. M.; Turtsevich, A. S.

    2014-07-01

    A technology for manufacture of a silicon Zener diode with a stabilizing voltage of 6.5 V has been proposed. The resistivity of the substrate and the regime of phosphorus diffusion into the substrate have been determined, which ensure required values of the stabilizing voltage under room-temperature conditions and at two boundary temperatures: -55 and 150°C. Modeling data have been compared to experimental results.

  5. Genetic algorithms in computer aided inductor design

    OpenAIRE

    Jean Fivaz; Willem A. Cronjé

    2004-01-01

    The goal of this investigation is to determine the advantages of using genetic algorithms in computer-aided design as applied to inductors.  These advantages are exploited in design problems with a number of specifications and constraints, as encountered in power electronics during practical inductor design. The design tool should be able to select components, such as cores and wires, from databases of available components, and evaluate these choices based on the components’ characteristic d...

  6. Technology computer aided design for Si, SiGe and GaAs integrated circuits

    CERN Document Server

    Armstrong, GA

    2007-01-01

    The first book to deal with a broad spectrum of process and device design, and modelling issues related to semiconductor devices, bridging the gap between device modelling and process design using TCAD. Examples for types of Si-, SiGe-, GaAs- and InP-based heterostructure MOS and bipolar transistors are compared with experimental data from state-of-the-art devices. With various aspects of silicon heterostructures, this book presents a comprehensive perspective of emerging fields and covers topics ranging from materials to fabrication, devices, modelling and applications. Aimed at research-and-

  7. Removal of Supernumerary Teeth Utilizing a Computer-Aided Design/Computer-Aided Manufacturing Surgical Guide.

    Science.gov (United States)

    Jo, Chanwoo; Bae, Doohwan; Choi, Byungho; Kim, Jihun

    2017-05-01

    Supernumerary teeth need to be removed because they can cause various complications. Caution is needed because their removal can cause damage to permanent teeth or tooth germs in the local vicinity. Surgical guides have recently been used in maxillofacial surgery. Because surgical guides are designed through preoperative analysis by computer-aided design software and fabricated using a 3-dimensional printer applying computer-aided manufacturing technology, they increase the accuracy and predictability of surgery. This report describes 2 cases of removal of a mesiodens-1 from a child and 1 from an adolescent-using a surgical guide; these would have been difficult to remove with conventional surgical methods. Copyright © 2016 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

  8. Computer-Aided Pneumatic Circuit Design

    OpenAIRE

    TEKİNER, Zafer; KORKUT, İhsan

    2001-01-01

    In this study, a user-interactive computer program was developed for computer-aided pneumatic circuit design. The pneumatic circuit elements were selected and designed by the determination of the main principles that are in accordance with the aim the user is going to specify. A database was established by forming IGES files for pneumatic circuit elements. In addition to this database, lists displaying the connection nodes of each element were prepared. The coordinates will be conne...

  9. Genetic algorithms in computer aided inductor design

    Directory of Open Access Journals (Sweden)

    Jean Fivaz

    2004-09-01

    Full Text Available The goal of this investigation is to determine the advantages of using genetic algorithms in computer-aided design as applied to inductors.  These advantages are exploited in design problems with a number of specifications and constraints, as encountered in power electronics during practical inductor design. The design tool should be able to select components, such as cores and wires, from databases of available components, and evaluate these choices based on the components’ characteristic data read from a database of manufacturers’ data-sheets.  The proposed design must always be practically realizable, as close to the desired specifications as possible and within any specified constraints.

  10. Computer-aided design of conveyor belts

    Energy Technology Data Exchange (ETDEWEB)

    Karolewski, B.; Pytel, J.

    1984-01-01

    Possibilities are discussed for using mathematical models of belt conveyors for development of computer-aided design of conveyors for coal mining. Examples of optimization tasks and methods for their solution using computerized simulation are analyzed. The analysis is illustrated by an algorithm used to design a starter for the drive system of a belt conveyor. Electromagnetic moment and starting current are used as optimization criteria. A simplified model of a belt conveyor is used. The model consists of an equation of motion with variable braking moment and variable moment of inertia. 3 references.

  11. Integrated computer-aided design using minicomputers

    Science.gov (United States)

    Storaasli, O. O.

    1980-01-01

    Computer-Aided Design/Computer-Aided Manufacturing (CAD/CAM), a highly interactive software, has been implemented on minicomputers at the NASA Langley Research Center. CAD/CAM software integrates many formerly fragmented programs and procedures into one cohesive system; it also includes finite element modeling and analysis, and has been interfaced via a computer network to a relational data base management system and offline plotting devices on mainframe computers. The CAD/CAM software system requires interactive graphics terminals operating at a minimum of 4800 bits/sec transfer rate to a computer. The system is portable and introduces 'interactive graphics', which permits the creation and modification of models interactively. The CAD/CAM system has already produced designs for a large area space platform, a national transonic facility fan blade, and a laminar flow control wind tunnel model. Besides the design/drafting element analysis capability, CAD/CAM provides options to produce an automatic program tooling code to drive a numerically controlled (N/C) machine. Reductions in time for design, engineering, drawing, finite element modeling, and N/C machining will benefit productivity through reduced costs, fewer errors, and a wider range of configuration.

  12. COMPUTER AIDED DESIGN OF CUTTING TOOLS

    Directory of Open Access Journals (Sweden)

    Jakub Matuszak

    2015-11-01

    Full Text Available Correct and stable machining process requires an appropriate cutting tool. In most cases the tool can be selected by using special tool catalogs often available in online version. But in some cases there is a need to design unusual tools, for special treatment, which are not available in tool manufacturers’ catalogs. Proper tool design requires strength and geometric calculations. Moreover, in many cases specific technical documentation is required. By using Computer Aided Design of cutting tools this task can be carried out quickly and with high accuracy. Cutting tool visualization in CAD programs gives a clear overview of the design process. Besides, these programs provide the ability to simulate real machining process. Nowadays, 3D modeling in CAD programs is a fundamental tool for engineers. Therefore, it is important to use them in the education process.

  13. Computer-Aided Design of Antimicrobial Peptides

    DEFF Research Database (Denmark)

    Fjell, Christopher D.; Hancock, Robert E.W.; Jenssen, Håvard

    2010-01-01

    chemical parameters with biological activities of the peptide, using statistical methods. In this review we will discuss two different in silico strategies of computer-aided antibacterial peptide design, a linear correlation model build as an extension of traditional principal component analysis (PCA......) and a non-linear artificial neural network model. Studies on structurally diverse peptides, have concluded that the PCA derived model are able to guide the antibacterial peptide design in a meaningful way, however requiring rather a high homology between the peptides in the test-set and the in silico...... library, to ensure a successful prediction. In contrast, the neural network model, though significantly less explored in relation to antimicrobial peptide design, has proven extremely promising, demonstrating impressive prediction success and ranking of random peptide libraries correlating well...

  14. Computer Aided Design Modeling for Heterogeneous Objects

    CERN Document Server

    Gupta, Vikas; Tandon, Puneet

    2010-01-01

    Heterogeneous object design is an active research area in recent years. The conventional CAD modeling approaches only provide geometry and topology of the object, but do not contain any information with regard to the materials of the object and so can not be used for the fabrication of heterogeneous objects (HO) through rapid prototyping. Current research focuses on computer-aided design issues in heterogeneous object design. A new CAD modeling approach is proposed to integrate the material information into geometric regions thus model the material distributions in the heterogeneous object. The gradient references are used to represent the complex geometry heterogeneous objects which have simultaneous geometry intricacies and accurate material distributions. The gradient references helps in flexible manipulability and control to heterogeneous objects, which guarantees the local control over gradient regions of developed heterogeneous objects. A systematic approach on data flow, processing, computer visualizat...

  15. Conceptual framework for the integration of computer-aided design and computer-aided process planning

    Energy Technology Data Exchange (ETDEWEB)

    Li, R.K.

    1986-01-01

    This research presents a conceptual framework for the integration of Computer-Aided Design (CAD) and Computer-Aided Process Planning (CAPP). The conceptual framework resides in an environmental of N CAD systems and M CAPP systems. It consists of three major modules: a generic-part definition data structure, a preprocessor, and a postprocessor. The generic-part definition data structure was developed to serve as a neutral-part definition data representation between CAD and CAPP systems. With this structure, the number of interfacing systems can be reduced to 1 + M systems. The preprocessor, a part feature recognition system, is designed to extract part definition data from an IGES file, evaluates that data, allows inclusion of unsupported data, and finally puts the data into the data structure. The postprocessor was written to convert the data from the data structure to the part input format of a selected CAPP system. A prototype systems that uses IBM's CAD package (CADAM), IGES and United Technologies Research Center's CAPP package (CMPP) was developed to test and prove the concept of this research. The input is a CADAM graphic design file and the outputs are a summary of operations and a tolerance control chart which are ready to be used in the production shops.

  16. U.S. aerospace industry opinion of the effect of computer-aided prediction-design technology on future wind-tunnel test requirements for aircraft development programs

    Science.gov (United States)

    Treon, S. L.

    1979-01-01

    A survey of the U.S. aerospace industry in late 1977 suggests that there will be an increasing use of computer-aided prediction-design technology (CPD Tech) in the aircraft development process but that, overall, only a modest reduction in wind-tunnel test requirements from the current level is expected in the period through 1995. Opinions were received from key spokesmen in 23 of the 26 solicited major companies or corporate divisions involved in the design and manufacture of nonrotary wing aircraft. Development programs for nine types of aircraft related to test phases and wind-tunnel size and speed range were considered.

  17. Computer Aided Solvent Selection and Design Framework

    DEFF Research Database (Denmark)

    Mitrofanov, Igor; Conte, Elisa; Abildskov, Jens

    , millions of tons solvents have to be wasted every year [2]. Therefore, it becomes important to minimize and optimize the use of organic solvents as much as possible, to satisfy the “Green Chemistry Principles” [3]. Another challenge is that currently solvent selection relies very much on previous...... is to develop a systematic framework and implement it as software for selection and design of solvents for many applications including organic synthesis, complex reaction systems and solvent-based separations. The solvent selection framework is based on a combination of knowledge from industrial practice...... identification of solvent candidates using special software ProCAMD and ProPred, which are the implementations of computer-aided molecular techniques. The second consists of assigning the RS-indices following the reaction–solvent and then consulting the known solvent database and identifying the set of solvents...

  18. Computer-Aided Drug Design Methods.

    Science.gov (United States)

    Yu, Wenbo; MacKerell, Alexander D

    2017-01-01

    Computational approaches are useful tools to interpret and guide experiments to expedite the antibiotic drug design process. Structure-based drug design (SBDD) and ligand-based drug design (LBDD) are the two general types of computer-aided drug design (CADD) approaches in existence. SBDD methods analyze macromolecular target 3-dimensional structural information, typically of proteins or RNA, to identify key sites and interactions that are important for their respective biological functions. Such information can then be utilized to design antibiotic drugs that can compete with essential interactions involving the target and thus interrupt the biological pathways essential for survival of the microorganism(s). LBDD methods focus on known antibiotic ligands for a target to establish a relationship between their physiochemical properties and antibiotic activities, referred to as a structure-activity relationship (SAR), information that can be used for optimization of known drugs or guide the design of new drugs with improved activity. In this chapter, standard CADD protocols for both SBDD and LBDD will be presented with a special focus on methodologies and targets routinely studied in our laboratory for antibiotic drug discoveries.

  19. A review of computer-aided design/computer-aided manufacture techniques for removable denture fabrication.

    Science.gov (United States)

    Bilgin, Mehmet Selim; Baytaroğlu, Ebru Nur; Erdem, Ali; Dilber, Erhan

    2016-01-01

    The aim of this review was to investigate usage of computer-aided design/computer-aided manufacture (CAD/CAM) such as milling and rapid prototyping (RP) technologies for removable denture fabrication. An electronic search was conducted in the PubMed/MEDLINE, ScienceDirect, Google Scholar, and Web of Science databases. Databases were searched from 1987 to 2014. The search was performed using a variety of keywords including CAD/CAM, complete/partial dentures, RP, rapid manufacturing, digitally designed, milled, computerized, and machined. The identified developments (in chronological order), techniques, advantages, and disadvantages of CAD/CAM and RP for removable denture fabrication are summarized. Using a variety of keywords and aiming to find the topic, 78 publications were initially searched. For the main topic, the abstract of these 78 articles were scanned, and 52 publications were selected for reading in detail. Full-text of these articles was gained and searched in detail. Totally, 40 articles that discussed the techniques, advantages, and disadvantages of CAD/CAM and RP for removable denture fabrication and the articles were incorporated in this review. Totally, 16 of the papers summarized in the table. Following review of all relevant publications, it can be concluded that current innovations and technological developments of CAD/CAM and RP allow the digitally planning and manufacturing of removable dentures from start to finish. As a result according to the literature review CAD/CAM techniques and supportive maxillomandibular relationship transfer devices are growing fast. In the close future, fabricating removable dentures will become medical informatics instead of needing a technical staff and procedures. However the methods have several limitations for now.

  20. Computer-aided design for metabolic engineering.

    Science.gov (United States)

    Fernández-Castané, Alfred; Fehér, Tamás; Carbonell, Pablo; Pauthenier, Cyrille; Faulon, Jean-Loup

    2014-12-20

    The development and application of biotechnology-based strategies has had a great socio-economical impact and is likely to play a crucial role in the foundation of more sustainable and efficient industrial processes. Within biotechnology, metabolic engineering aims at the directed improvement of cellular properties, often with the goal of synthesizing a target chemical compound. The use of computer-aided design (CAD) tools, along with the continuously emerging advanced genetic engineering techniques have allowed metabolic engineering to broaden and streamline the process of heterologous compound-production. In this work, we review the CAD tools available for metabolic engineering with an emphasis, on retrosynthesis methodologies. Recent advances in genetic engineering strategies for pathway implementation and optimization are also reviewed as well as a range of bionalytical tools to validate in silico predictions. A case study applying retrosynthesis is presented as an experimental verification of the output from Retropath, the first complete automated computational pipeline applicable to metabolic engineering. Applying this CAD pipeline, together with genetic reassembly and optimization of culture conditions led to improved production of the plant flavonoid pinocembrin. Coupling CAD tools with advanced genetic engineering strategies and bioprocess optimization is crucial for enhanced product yields and will be of great value for the development of non-natural products through sustainable biotechnological processes.

  1. Methodology for Benefit Analysis of CAD/CAM (Computer-Aided Design/Computer-Aided Manufacturing) in USN Shipyards.

    Science.gov (United States)

    1984-03-01

    benefits of CAD/CAR and of the next generation technology, CIDER . The CADOS study (Ref. 13] offers a method to measure the intangibles of CAD/CAR...methodology that measures both tangible and intangible benefits of present CAD technology. This method would be hard to extend to CIDER technology because of...D-Ri38 398 METHODOLOGY FOR BENEFIT ANALYSIS OF CAD/CAM / (COMPUTER-HIDED DESIGN/COMPUTER-AIDED MANUFACTURING) IN USN SHIPYARDS(U) NAVAL POSTGRADUATE

  2. Software For Computer-Aided Design Of Control Systems

    Science.gov (United States)

    Wette, Matthew

    1994-01-01

    Computer Aided Engineering System (CAESY) software developed to provide means to evaluate methods for dealing with users' needs in computer-aided design of control systems. Interpreter program for performing engineering calculations. Incorporates features of both Ada and MATLAB. Designed to be flexible and powerful. Includes internally defined functions, procedures and provides for definition of functions and procedures by user. Written in C language.

  3. Computer aided pantograph design for garment panels

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Discusses the difficulties and problems with manual pantograph ofgarment panels, introduces several typical pantographic ways and their characteristics both at home and abroad, presents a new pantographic method based on similar figures developed to overcome the deficiency of those methods, so as to realize computer aid automatic panel pantograph.

  4. Exploratory research for the development of a computer aided software design environment with the software technology program

    Science.gov (United States)

    Hardwick, Charles

    1991-01-01

    Field studies were conducted by MCC to determine areas of research of mutual interest to MCC and JSC. NASA personnel from the Information Systems Directorate and research faculty from UHCL/RICIS visited MCC in Austin, Texas to examine tools and applications under development in the MCC Software Technology Program. MCC personnel presented workshops in hypermedia, design knowledge capture, and design recovery on site at JSC for ISD personnel. The following programs were installed on workstations in the Software Technology Lab, NASA/JSC: (1) GERM (Graphic Entity Relations Modeler); (2) gIBIS (Graphic Issues Based Information System); and (3) DESIRE (Design Recovery tool). These applications were made available to NASA for inspection and evaluation. Programs developed in the MCC Software Technology Program run on the SUN workstation. The programs do not require special configuration, but they will require larger than usual amounts of disk space and RAM to operate properly.

  5. Computer-aided dispatching system design specification

    Energy Technology Data Exchange (ETDEWEB)

    Briggs, M.G.

    1997-12-16

    This document defines the performance requirements for a graphic display dispatching system to support Hanford Patrol Operations Center. This document reflects the as-built requirements for the system that was delivered by GTE Northwest, Inc. This system provided a commercial off-the-shelf computer-aided dispatching system and alarm monitoring system currently in operations at the Hanford Patrol Operations Center, Building 2721E. This system also provides alarm back-up capability for the Plutonium Finishing Plant (PFP).

  6. Computer-aided Translation Technology and Its Applications

    Institute of Scientific and Technical Information of China (English)

    汪美侠; 何大顺

    2014-01-01

    This article begins with a brief analysis of the significance of translation technology in different spheres of modern life, followed by a distinction between machine translation (MT) and computer-aided translation (CAT). It then describes some trans-lation resources and tools and examines the negative and positive aspects of computer-aided translations. Finally it comes to a conclusion that it would be greatly efficient and productive for the translators to acquire the new skills in the translation work-place.

  7. PLAID- A COMPUTER AIDED DESIGN SYSTEM

    Science.gov (United States)

    Brown, J. W.

    1994-01-01

    PLAID is a three-dimensional Computer Aided Design (CAD) system which enables the user to interactively construct, manipulate, and display sets of highly complex geometric models. PLAID was initially developed by NASA to assist in the design of Space Shuttle crewstation panels, and the detection of payload object collisions. It has evolved into a more general program for convenient use in many engineering applications. Special effort was made to incorporate CAD techniques and features which minimize the users workload in designing and managing PLAID models. PLAID consists of three major modules: the Primitive Object Generator (BUILD), the Composite Object Generator (COG), and the DISPLAY Processor. The BUILD module provides a means of constructing simple geometric objects called primitives. The primitives are created from polygons which are defined either explicitly by vertex coordinates, or graphically by use of terminal crosshairs or a digitizer. Solid objects are constructed by combining, rotating, or translating the polygons. Corner rounding, hole punching, milling, and contouring are special features available in BUILD. The COG module hierarchically organizes and manipulates primitives and other previously defined COG objects to form complex assemblies. The composite object is constructed by applying transformations to simpler objects. The transformations which can be applied are scalings, rotations, and translations. These transformations may be defined explicitly or defined graphically using the interactive COG commands. The DISPLAY module enables the user to view COG assemblies from arbitrary viewpoints (inside or outside the object) both in wireframe and hidden line renderings. The PLAID projection of a three-dimensional object can be either orthographic or with perspective. A conflict analysis option enables detection of spatial conflicts or collisions. DISPLAY provides camera functions to simulate a view of the model through different lenses. Other

  8. Computer-aided design development transition for IPAD environment

    Science.gov (United States)

    Owens, H. G.; Mock, W. D.; Mitchell, J. C.

    1980-01-01

    The relationship of federally sponsored computer-aided design/computer-aided manufacturing (CAD/CAM) programs to the aircraft life cycle design process, an overview of NAAD'S CAD development program, an evaluation of the CAD design process, a discussion of the current computing environment within which NAAD is developing its CAD system, some of the advantages/disadvantages of the NAAD-IPAD approach, and CAD developments during transition into the IPAD system are discussed.

  9. On computer-aided design of aerospace vehicles

    Science.gov (United States)

    Sobieszczanski, J. E.; Voigt, S. J.; Fulton, R. E.

    1974-01-01

    Digital computers are being used in many engineering activities to support design work. This paper provides an overview of some of this work as it relates to the design of aerospace vehicles. Discussions are given of some of the complexities of the design process which lead to large design costs and time. A number of important but disjointed computer capabilities have evolved over the years in analysis, optimization, and graphics, and such capabilities aid in addressing the problem of design complexity. Examples of existing computer-aided design (CAD) systems are given and trends for future CAD systems are indicated, as well as their relationship to pertinent data management technology. It is suggested that major gains in design capability will occur through continued development of CAD methodology and that these gains may be accelerated through a large focused effort.

  10. Computer Aided Design Tools for Extreme Environment Electronics Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This project aims to provide Computer Aided Design (CAD) tools for radiation-tolerant, wide-temperature-range digital, analog, mixed-signal, and radio-frequency...

  11. Data-driven computer aided synthesis design.

    Science.gov (United States)

    Ravitz, Orr

    2013-09-01

    Enabled by an increasing body of electronically available experimental data and by advances in computer hardware and software, new technologies are emerging that are designed to support the creativity of chemists during synthesis planning. Leading this development are innovative synthetic route prediction tools that are designed to suggest new reactions and paths to target molecules as an idea-generating engine. Other tools are using known reactions in a combinatorial fashion to suggest new routes that are cost-optimized or satisfy some other global criteria. We review the latest developments and the main tools in this domain.

  12. CAD/CAM (Computer Aided Design/Computer Aided Manufacture). A Brief Guide to Materials in the Library of Congress.

    Science.gov (United States)

    Havas, George D.

    This brief guide to materials in the Library of Congress (LC) on computer aided design and/or computer aided manufacturing lists reference materials and other information sources under 13 headings: (1) brief introductions; (2) LC subject headings used for such materials; (3) textbooks; (4) additional titles; (5) glossaries and handbooks; (6)…

  13. Veneer computer aided design based on reverse engineering technology%基于逆向工程技术的贴面计算机辅助设计

    Institute of Scientific and Technical Information of China (English)

    刘明丽; 陈小冬; 王勇

    2012-01-01

    目的 探索符合形态美学要求的贴面计算机辅助设计(computer aided design,CAD)方法,为贴面专用CAD平台的开发提供方法学基础.方法 选择1例右上中切牙变色需贴面修复的患者,取牙体预备前与预备后两副超硬石膏模型,牙体预备成切端对接型,经三维激光扫描仪三维数据采集、三维重建、使用逆向工程软件Surfacer10.5与Geomagic Studio 8.0进行贴面CAD.结果 在逆向工程软件基础上确立了贴面CAD的技术路线,完成后的贴面表面光顺,与对侧同名牙对称协调,符合形态美学仿真修复要求.结论 基于逆向工程技术进行贴面CAD,方法简便可行,为自主知识产权贴面CAD软件的开发提供了必要的方法学基础.%Objective To explore the computer aided design (CAD) method of veneer restoration,and to assess if the solution can help prosthesis meet morphology esthetics standard.Methods A volunteer's upper right central incisor needed to be restored with veneer.Super hard stone models of patient's dentition (before and after tooth preparation) were scanned with the three-dimensional laser scanner. The veneer margin was designed as butt-to-butt type.The veneer was constructed using reverse engineering (RE) software.Results The technique guideline of veneers CAD was explore based on RE software,and the veneers was smooth,continuous and symmetrical,which met esthetics construction needs.Conclusions It was a feasible method to reconstruct veneer restoration based on RE technology.

  14. Validated physical models and parameters of bulk 3C–SiC aiming for credible technology computer aided design (TCAD) simulation

    Science.gov (United States)

    Arvanitopoulos, A.; Lophitis, N.; Gyftakis, K. N.; Perkins, S.; Antoniou, M.

    2017-10-01

    The cubic form of SiC (β- or 3C-) compared to the hexagonal α-SiC polytypes, primarily 4H- and 6H–SiC, has lower growth cost and can be grown heteroepitaxially in large area silicon (Si) wafers which makes it of special interest. This in conjunction with the recently reported growth of improved quality 3C–SiC, make the development of devices an imminent objective. However, the readiness of models that accurately predict the material characteristics, properties and performance is an imperative requirement for attaining the design and optimization of functional devices. The purpose of this study is to provide and validate a comprehensive set of models alongside with their parameters for bulk 3C–SiC. The validation process revealed that the proposed models are in a very good agreement to experimental data and confidence ranges were identified. This is the first piece of work achieving that for 3C–SiC. Considerably, it constitutes the necessary step for finite element method simulations and technology computer aided design.

  15. Technology computer aided design of 29.5% efficient perovskite/interdigitated back contact silicon heterojunction mechanically stacked tandem solar cell for energy-efficient applications

    Science.gov (United States)

    Pandey, Rahul; Chaujar, Rishu

    2017-04-01

    A 29.5% efficient perovskite/SiC passivated interdigitated back contact silicon heterojunction (IBC-SiHJ) mechanically stacked tandem solar cell device has been designed and simulated. This is a substantial improvement of 40% and 15%, respectively, compared to the transparent perovskite solar cell (21.1%) and Si solar cell (25.6%) operated individually. The perovskite solar cell has been used as a top subcell, whereas 250- and 25-μm-thick IBC-SiHJ solar cells have been used as bottom subcells. The realistic technology computer aided design analysis has been performed to understand the physical processes in the device and to make reliable predictions of the behavior. The performance of the top subcell has been obtained for different acceptor densities and hole mobility in Spiro-MeOTAD along with the impact of counter electrode work function. To incorporate the effect of material quality, the influence of carrier lifetimes has also been studied for perovskite top and IBC-SiHJ bottom subcells. The optical and electrical behavior of the devices has been obtained for both standalone as well as tandem configuration. Results reported in this study reveal that the proposed four-terminal tandem device may open a new door for cost-effective and energy-efficient applications.

  16. Research and optimization of the technological process of manufacturing a GTE blades using computer-aided design

    Science.gov (United States)

    Vdovin, R. A.; Smelov, V. G.

    2016-11-01

    This paper discusses an approach to prediction of the generation of pouring defects using the example of a technological process of manufacturing GTE blades. A computer-based modeling system for foundry processes, ProCast, was used as a tool for this research. Possible reasons of the formation of defects were considered and the recommendations for their elimination were provided.

  17. Microwave processing of a dental ceramic used in computer-aided design/computer-aided manufacturing.

    Science.gov (United States)

    Pendola, Martin; Saha, Subrata

    2015-01-01

    Because of their favorable mechanical properties and natural esthetics, ceramics are widely used in restorative dentistry. The conventional ceramic sintering process required for their use is usually slow, however, and the equipment has an elevated energy consumption. Sintering processes that use microwaves have several advantages compared to regular sintering: shorter processing times, lower energy consumption, and the capacity for volumetric heating. The objective of this study was to test the mechanical properties of a dental ceramic used in computer-aided design/computer-aided manufacturing (CAD/CAM) after the specimens were processed with microwave hybrid sintering. Density, hardness, and bending strength were measured. When ceramic specimens were sintered with microwaves, the processing times were reduced and protocols were simplified. Hardness was improved almost 20% compared to regular sintering, and flexural strength measurements suggested that specimens were approximately 50% stronger than specimens sintered in a conventional system. Microwave hybrid sintering may preserve or improve the mechanical properties of dental ceramics designed for CAD/CAM processing systems, reducing processing and waiting times.

  18. Updates on the Construction of an Eyeglass-Supported Nasal Prosthesis Using Computer-Aided Design and Rapid Prototyping Technology.

    Science.gov (United States)

    Ciocca, Leonardo; Tarsitano, Achille; Marchetti, Claudio; Scotti, Roberto

    2016-01-01

    This study was undertaken to design an updated connection system for an eyeglass-supported nasal prosthesis using rapid prototyping techniques. The substructure was developed with two main endpoints in mind: the connection to the silicone and the connection to the eyeglasses. The mold design was also updated; the mold was composed of various parts, each carefully designed to allow for easy release after silicone processing and to facilitate extraction of the prosthesis without any strain. The approach used in this study enabled perfect transfer of the reciprocal position of the prosthesis with respect to the eyeglasses, from the virtual to the clinical environment. Moreover, the reduction in thickness improved the flexibility of the prosthesis and promoted adaptation to the contours of the skin, even during functional movements. The method described here is a simplified and viable alternative to standard construction techniques for nasal prostheses and offers improved esthetic and functional results when no bone is available for implant-supported prostheses.

  19. Computer aided microbial safety design of food processes.

    Science.gov (United States)

    Schellekens, M; Martens, T; Roberts, T A; Mackey, B M; Nicolaï, B M; Van Impe, J F; De Baerdemaeker, J

    1994-12-01

    To reduce the time required for product development, to avoid expensive experimental tests, and to quantify safety risks for fresh products and the consequence of processing there is a growing interest in computer aided food process design. This paper discusses the application of hybrid object-oriented and rule-based expert system technology to represent the data and knowledge of microbial experts and food engineers. Finite element models for heat transfer calculation routines, microbial growth and inactivation models and texture kinetics are combined with food composition data, thermophysical properties, process steps and expert knowledge on type and quantity of microbial contamination. A prototype system has been developed to evaluate changes in food composition, process steps and process parameters on microbiological safety and textual quality of foods.

  20. Adhesive Bonding to Computer-aided Design/ Computer-aided Manufacturing Esthetic Dental Materials: An Overview.

    Science.gov (United States)

    Awad, Mohamed Moustafa; Alqahtani, H; Al-Mudahi, A; Murayshed, M S; Alrahlah, A; Bhandi, Shilpa H

    2017-07-01

    To review the adhesive bonding to different computer-aided design/computer-aided manufacturing (CAD/CAM) esthetic restorative materials. The use of CAD/CAM esthetic restorative materials has gained popularity in recent years. Several CAD/ CAM esthetic restorative materials are commercially available. Adhesive bonding is a major determinant of success of CAD/ CAM restorations. Review result: An account of the currently available bonding strategies are discussed with their rationale in various CAD/ CAM materials. Different surface treatment methods as well as adhesion promoters can be used to achieve reliable bonding of CAD/CAM restorative materials. Selection of bonding strategy to such material is determined based on its composition. Further evidence is required to evaluate the effect of new surface treatment methods, such as nonthermal atmospheric plasma and self-etching ceramic primer on bonding to different dental ceramics. An understanding of the currently available bonding strategies to CA/CAM materials can help the clinician to select the most indicated system for each category of materials.

  1. De novo computer-aided design of novel antiviral agents.

    Science.gov (United States)

    Massarotti, Alberto; Coluccia, Antonio; Sorba, Giovanni; Silvestri, Romano; Brancale, Andrea

    2012-01-01

    Computer-aided drug design techniques have become an integral part of the drug discovery process. In particular, de novo methodologies can be useful to identify putative ligands for a specific target relying only on the structural information of the target itself. Here we discuss the basic de novo approaches available and their application in antiviral drug design.:

  2. Performative Computation-aided Design Optimization

    Directory of Open Access Journals (Sweden)

    Ming Tang

    2012-12-01

    Full Text Available This article discusses a collaborative research and teaching project between the University of Cincinnati, Perkins+Will’s Tech Lab, and the University of North Carolina Greensboro. The primary investigation focuses on the simulation, optimization, and generation of architectural designs using performance-based computational design approaches. The projects examine various design methods, including relationships between building form, performance and the use of proprietary software tools for parametric design.

  3. Computer-aided design of GPCR ligands.

    Science.gov (United States)

    Gutiérrez-de-Terán, Hugo; Keränen, Henrik; Azuaje, Jhonny; Rodríguez, David; Åqvist, Johan; Sotelo, Eddy

    2015-01-01

    The recent availability of several GPCR crystal structures now contributes decisively to the perspective of structure-based ligand design. In this context, computational approaches are extremely helpful, particularly if properly integrated in drug design projects with cooperation between computational and medicinal chemistry teams. Here, we present the pipelines used in one such project, devoted to the design of novel potent and selective antagonists for the different adenosine receptors. The details of the computational strategies are described, and particular attention is given to explain how these procedures can effectively guide the synthesis of novel chemical entities.

  4. Computer-aided design of tension structures

    OpenAIRE

    Ong, C.F.

    1992-01-01

    This thesis consists of three parts. Part I (chapters 1-4) gives a review and description of the basis for the numerical modelling of tension structures. The discussion in Part I leads to the conclusion of a need for an interactive design procedure for tension structures which is the subject under consideration in Part II (chapters 5-7). In the design of tension structures, an area which requires special attention is the dynamic response often initiated by the action of a natural wind. In Par...

  5. The Journal of Computer- Aided Molecular Design: a bibliometric note

    Science.gov (United States)

    Willett, Peter

    2012-01-01

    Summarizes the articles in, and the citations to, volumes 2-24 of the Journal of Computer- Aided Molecular Design. The citations to the journal come from almost 2000 different sources that span a very wide range of academic subjects, with the most heavily cited articles being descriptions of software systems and of computational methods.

  6. Computer-Aided Modeling of Lipid Processing Technology

    DEFF Research Database (Denmark)

    Diaz Tovar, Carlos Axel

    2011-01-01

    are widely used for design, analysis, and optimization of processes in the chemical and petrochemical industries. These computer-aided tools have helped the chemical industry to evolve beyond commodities toward specialty chemicals and ‘consumer oriented chemicals based products’. Unfortunately...... this is not the case for the edible oil and biodiesel industries. The oleochemical industry lags behind the chemical industry in terms of thermophysical property modeling and development of computational tools suitable for the design/analysis, and optimization of lipid-related processes. The aim of this work has been...... increase along with growing interest in biofuels, the oleochemical industry faces in the upcoming years major challenges in terms of design and development of better products and more sustainable processes to make them. Computer-aided methods and tools for process synthesis, modeling and simulation...

  7. Computer Aided Design System for Developing Musical Fountain Programs

    Institute of Scientific and Technical Information of China (English)

    刘丹; 张乃尧; 朱汉城

    2003-01-01

    A computer aided design system for developing musical fountain programs was developed with multiple functions such as intelligent design, 3-D animation, manual modification and synchronized motion to make the development process more efficient. The system first analyzed the music form and sentiment using many basic features of the music to select a basic fountain program. Then, this program is simulated with 3-D animation and modified manually to achieve the desired results. Finally, the program is transformed to a computer control program to control the musical fountain in time with the music. A prototype system for the musical fountain was also developed. It was tested with many styles of music and users were quite satisfied with its performance. By integrating various functions, the proposed computer aided design system for developing musical fountain programs greatly simplified the design of the musical fountain programs.

  8. The computer-aided design of rubber-metal products

    Directory of Open Access Journals (Sweden)

    Pavlo S. Shvets

    2015-12-01

    Full Text Available The important problem in design of rubber-metal products is the optimization of their mass without sacrificing of proportionality factor is in the limits of standard. Aim: The aim of this work is to improve the computer-aided systems by development and implementation of improved optimization method in rubber-metal CAD systems for designers based on the reverse optimization. Materials and Methods: The paper studies the matters of computer-aided structural design of technical composite products composed of anisotropic materials that are essentially different in properties. Results: The structure of CAD systems for designers solving the problems of such design is offered and the work principles of its subsystems are described. It is shown that complicated systems optimization in CAD systems must consider as restrictions the entitative connection between separate elements of these systems within the area of the optimizing arguments. Conclusions: The problem of the “reverse” optimization when objective functions are the connectivity area parameters is considered. In many cases, this allows receiving solutions that are more effective during the computer-aided design process. The developed CAD system for designers was used during the production of rubber-metal shock absorbers at the Odessa Rubber Technical Articles Plant. The positive technical and economic effect was obtained.

  9. Computer-Aided Design Of Sheet-Material Parts

    Science.gov (United States)

    Gilbert, Jeffrey L.; Paternoster, Vincent Y.; Levitt, Maureen L.; Osterloh, Mark R.

    1991-01-01

    Computer-aided-design system partly automates tedious process of designing and guiding assembly of small pieces of flat sheet material into large surfaces that approximate smoothly curved surfaces having complicated three-dimensional shapes. Capability provides for flexibility enabling designer to assess quickly and easily effects of changes in design in making engineering compromises among various sizes and shapes. Saves time and money in both design and fabrication. Used in rocket-engine application and other applications requiring design of sheet-material parts.

  10. SNL Mechanical Computer Aided Design (MCAD) guide 2007.

    Energy Technology Data Exchange (ETDEWEB)

    Moore, Brandon; Pollice, Stephanie L.; Martinez, Jack R.

    2007-12-01

    This document is considered a mechanical design best-practice guide to new and experienced designers alike. The contents consist of topics related to using Computer Aided Design (CAD) software, performing basic analyses, and using configuration management. The details specific to a particular topic have been leveraged against existing Product Realization Standard (PRS) and Technical Business Practice (TBP) requirements while maintaining alignment with sound engineering and design practices. This document is to be considered dynamic in that subsequent updates will be reflected in the main title, and each update will be published on an annual basis.

  11. A critically appraised topic review of computer-aided design/computer-aided machining of removable partial denture frameworks.

    Science.gov (United States)

    Lang, Lisa A; Tulunoglu, Ibrahim

    2014-01-01

    A critically appraised topic (CAT) review is presented about the use of computer-aided design (CAD)/computer-aided machining (CAM) removable partial denture (RPD) frameworks. A systematic search of the literature supporting CAD/CAM RPD systems revealed no randomized clinical trials, hence the CAT review was performed. A PubMed search yielded 9 articles meeting the inclusion criteria. Each article was characterized by study design and level of evidence. No clinical outcomes research has been published on the use of CAD/CAM RPDs. Low levels of evidence were found in the available literature. Clinical research studies are needed to determine the efficacy of this treatment modality.

  12. Efficient Use of Preisach Hysteresis Model in Computer Aided Design

    Directory of Open Access Journals (Sweden)

    IONITA, V.

    2013-05-01

    Full Text Available The paper presents a practical detailed analysis regarding the use of the classical Preisach hysteresis model, covering all the steps, from measuring the necessary data for the model identification to the implementation in a software code for Computer Aided Design (CAD in Electrical Engineering. An efficient numerical method is proposed and the hysteresis modeling accuracy is tested on magnetic recording materials. The procedure includes the correction of the experimental data, which are used for the hysteresis model identification, taking into account the demagnetizing effect for the sample that is measured in an open-circuit device (a vibrating sample magnetometer.

  13. The Computer Aided Aircraft-design Package (CAAP)

    Science.gov (United States)

    Yalif, Guy U.

    1994-01-01

    The preliminary design of an aircraft is a complex, labor-intensive, and creative process. Since the 1970's, many computer programs have been written to help automate preliminary airplane design. Time and resource analyses have identified, 'a substantial decrease in project duration with the introduction of an automated design capability'. Proof-of-concept studies have been completed which establish 'a foundation for a computer-based airframe design capability', Unfortunately, today's design codes exist in many different languages on many, often expensive, hardware platforms. Through the use of a module-based system architecture, the Computer aided Aircraft-design Package (CAAP) will eventually bring together many of the most useful features of existing programs. Through the use of an expert system, it will add an additional feature that could be described as indispensable to entry level engineers and students: the incorporation of 'expert' knowledge into the automated design process.

  14. Computer-Aided Modeling of Lipid Processing Technology

    DEFF Research Database (Denmark)

    Diaz Tovar, Carlos Axel

    2011-01-01

    the analysis, in terms of their design variables and their impact in the process behavior, of three lipid-related processes has been performed: the solvent recovery section of the extraction of crude soybean oil, the deodorization of palm oil, and the deacidification of soybean oil.......Vegetable oils and fats have an important role in human nutrition and in the chemical industry since they are a source of energy, fat-soluble vitamins, and now also in the production of renewable sources of energy. Nowadays as the consumer preferences for natural products and healthier foods...... increase along with growing interest in biofuels, the oleochemical industry faces in the upcoming years major challenges in terms of design and development of better products and more sustainable processes to make them. Computer-aided methods and tools for process synthesis, modeling and simulation...

  15. Computer-aided conceptual design of Air Cushion Vehicles

    Science.gov (United States)

    Band, E. G. U.; Lavis, D. R.

    This paper describes the development and use of a computer-aided design tool which has been used to explore preferred options for amphibious Air-Cushion Vehicle (ACV) and Surface-Effect Ship (SES) designs in support of U.S. Navy and U.S. Army programs. The tool, referred to as the ACV Design Synthesis Model (ADSM), is an interactive computer program which provides a description of feasible ACV or SES concepts that could be developed, by a competent design team, to perform the mission described by the input parameters. The paper discusses how the program was used to explore parametrically the design of a range of self-propelled hoverbarges to meet requirements of the U.S. Army Logistics Over the Shore (LOTS) phases of an amphibious landing. Examples of results are presented to illustrate the method used in determining design and performance trade-offs.

  16. Computer- Aided Design in Power Engineering Application of Software Tools

    CERN Document Server

    Stojkovic, Zlatan

    2012-01-01

    This textbooks demonstrates the application of software tools in solving a series of problems from the field of designing power system structures and systems. It contains four chapters: The first chapter leads the reader through all the phases necessary in the procedures of computer aided modeling and simulation. It guides through the complex problems presenting on the basis of eleven original examples. The second chapter presents  application of software tools in power system calculations of power systems equipment design. Several design example calculations are carried out using engineering standards like MATLAB, EMTP/ATP, Excel & Access, AutoCAD and Simulink. The third chapters focuses on the graphical documentation using a collection of software tools (AutoCAD, EPLAN, SIMARIS SIVACON, SIMARIS DESIGN) which enable the complete automation of the development of graphical documentation of a power systems. In the fourth chapter, the application of software tools in the project management in power systems ...

  17. Evolution of Geometric Sensitivity Derivatives from Computer Aided Design Models

    Science.gov (United States)

    Jones, William T.; Lazzara, David; Haimes, Robert

    2010-01-01

    The generation of design parameter sensitivity derivatives is required for gradient-based optimization. Such sensitivity derivatives are elusive at best when working with geometry defined within the solid modeling context of Computer-Aided Design (CAD) systems. Solid modeling CAD systems are often proprietary and always complex, thereby necessitating ad hoc procedures to infer parameter sensitivity. A new perspective is presented that makes direct use of the hierarchical associativity of CAD features to trace their evolution and thereby track design parameter sensitivity. In contrast to ad hoc methods, this method provides a more concise procedure following the model design intent and determining the sensitivity of CAD geometry directly to its respective defining parameters.

  18. Computer-Aided Design and Computer-Aided Manufacturing Hydroxyapatite/Epoxide Acrylate Maleic Compound Construction for Craniomaxillofacial Bone Defects.

    Science.gov (United States)

    Zhang, Lei; Shen, Shunyao; Yu, Hongbo; Shen, Steve Guofang; Wang, Xudong

    2015-07-01

    The aim of this study was to investigate the use of computer-aided design and computer-aided manufacturing hydroxyapatite (HA)/epoxide acrylate maleic (EAM) compound construction artificial implants for craniomaxillofacial bone defects. Computed tomography, computer-aided design/computer-aided manufacturing and three-dimensional reconstruction, as well as rapid prototyping were performed in 12 patients between 2008 and 2013. The customized HA/EAM compound artificial implants were manufactured through selective laser sintering using a rapid prototyping machine into the exact geometric shapes of the defect. The HA/EAM compound artificial implants were then implanted during surgical reconstruction. Color-coded superimpositions demonstrated the discrepancy between the virtual plan and achieved results using Geomagic Studio. As a result, the HA/EAM compound artificial bone implants were perfectly matched with the facial areas that needed reconstruction. The postoperative aesthetic and functional results were satisfactory. The color-coded superimpositions demonstrated good consistency between the virtual plan and achieved results. The three-dimensional maximum deviation is 2.12 ± 0.65  mm and the three-dimensional mean deviation is 0.27 ± 0.07  mm. No facial nerve weakness or pain was observed at the follow-up examinations. Only 1 implant had to be removed 2 months after the surgery owing to severe local infection. No other complication was noted during the follow-up period. In conclusion, computer-aided, individually fabricated HA/EAM compound construction artificial implant was a good craniomaxillofacial surgical technique that yielded improved aesthetic results and functional recovery after reconstruction.

  19. Implementation Methods of Computer Aided Design-Drawing and Drawing Management for Plate Cutting-Machine

    Institute of Scientific and Technical Information of China (English)

    DONG Yu-de; ZHAO Han; TAN Jian-rong

    2002-01-01

    The implementation methods of computer aided design,drawing and drawing management for plate cuttingmachine are discussed. The system structure for plate cutting- machine design is put forward firstly, then some key technologies and their implementation methods are introduced, which include the structure management of graphics, the unification of graph and design calculation, information share of part, assemble and drawing management system, and movement simulation of key components.

  20. Systematic Computer-Aided Framework for Sustainable Chemical Product Design

    DEFF Research Database (Denmark)

    Cignitti, Stefano; Zhang, Lei; Kalakul, Sawitree

    Computer-aided product design (CAPD) is a method for the generation and selection of novel pure, mixed and blended chemical products [1]. In CAPD, the chemical product is generated and selected based on defined structure, property and process/application constraints. Several challenges exist...... for CAPD, including the accuracy of the property estimation, molecular structure generation, inclusion of sustainability, process and application targets and needs in the problem formulation. CAPD has been widely utilized for the synthesis of several types of products, such as solvents, polymers, fuels...... and formulated products [2]. However, for product design problems where the process needs and sustainability possess demanding constraints, the complexity of the problem is increased as the relation between product property, sustainability and process criteria is difficult to mathematically define. In this work...

  1. Computer-Aided Design System for CP Single-Screw Compressor

    Institute of Scientific and Technical Information of China (English)

    SHEN Jing-feng; YAO Fu-sheng

    2006-01-01

    To design various optimum parameters and simulate the working process of CP single-screw compressor,the Computer-Aided Design(CAD)system for the CP singlescrew compressor has been established.A new method based on computer graphics technology,database technology,object-oriented programming technology,and visual simulation technology has been adopted in this CAD system.The system has integrated solid modeling function with parameterization design function and animator simulation function based on analyzing the working principle of the CP single-screw compressor.The experimental results show fhat the CAD system for the CP single-screw compressor is practical and feasible.

  2. Correction of facial and mandibular asymmetry using a computer aided design/computer aided manufacturing prefabricated titanium implant.

    Science.gov (United States)

    Watson, Jason; Hatamleh, Muhanad; Alwahadni, Ahed; Srinivasan, Dilip

    2014-05-01

    Patients with significant craniofacial asymmetry may have functional problems associated with their occlusion and aesthetic concerns related to the imbalance in soft and hard tissue profiles. This report details a case of facial asymmetry secondary to left mandible angle deficiency due to undergoing previous radiotherapy. We describe the correction of the bony deformity using computer aided design/computer aided manufacturing custom-made titanium onlay using novel direct metal laser sintering. The direct metal laser sintering onlay proved a very accurate operative fit and showed a good aesthetic correction of the bony defect with no reported complications postoperatively. It is a useful low-morbidity technique, and there is no resorption or associated donor-site complications.

  3. [The automatic iris map overlap technology in computer-aided iridiagnosis].

    Science.gov (United States)

    He, Jia-feng; Ye, Hu-nian; Ye, Miao-yuan

    2002-11-01

    In the paper, iridology and computer-aided iridiagnosis technologies are briefly introduced and the extraction method of the collarette contour is then investigated. The iris map can be overlapped on the original iris image based on collarette contour extraction. The research on collarette contour extraction and iris map overlap is of great importance to computer-aided iridiagnosis technologies.

  4. Converting Between PLY and Ballistic Research Laboratory-Computer-Aided Design (BRL-CAD) File Formats

    Science.gov (United States)

    2015-02-01

    Converting Between PLY and Ballistic Research Laboratory–Computer-Aided Design (BRL- CAD ) File Formats by Rishub Jain ARL-CR-0760...0760 February 2015 Converting Between PLY and Ballistic Research Laboratory–Computer-Aided Design (BRL- CAD ) File Formats Rishub Jain US...and Ballistic Research Laboratory–Computer-Aided Design (BRL- CAD ) File Formats 5a. CONTRACT NUMBER W911NF-10-2-0076 5b. GRANT NUMBER 5c. PROGRAM

  5. Target Impact Detection Algorithm Using Computer-aided Design (CAD) Model Geometry

    Science.gov (United States)

    2014-09-01

    UNCLASSIFIED AD-E403 558 Technical Report ARMET-TR-13024 TARGET IMPACT DETECTION ALGORITHM USING COMPUTER-AIDED DESIGN ( CAD ...DETECTION ALGORITHM USING COMPUTER-AIDED DESIGN ( CAD ) MODEL GEOMETRY 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6...This report documents a method and algorithm to export geometry from a three-dimensional, computer-aided design ( CAD ) model in a format that can be

  6. Computer aided polymer design using multi-scale modelling

    Directory of Open Access Journals (Sweden)

    K. C. Satyanarayana

    2010-09-01

    Full Text Available The ability to predict the key physical and chemical properties of polymeric materials from their repeat-unit structure and chain-length architecture prior to synthesis is of great value for the design of polymer-based chemical products, with new functionalities and improved performance. Computer aided molecular design (CAMD methods can expedite the design process by establishing input-output relations between the type and number of functional groups in a polymer repeat unit and the desired macroscopic properties. A multi-scale model-based approach that combines a CAMD technique based on group contribution plus models for predicting polymer repeat unit properties with atomistic simulations for providing first-principles arrangements of the repeat units and for predictions of physical properties of the chosen candidate polymer structures, has been developed and tested for design of polymers with desired properties. A case study is used to highlight the main features of this multi-scale model-based approach for the design of a polymer-based product.

  7. A digital patient for computer-aided prosthesis design.

    Science.gov (United States)

    Colombo, Giorgio; Facoetti, Giancarlo; Rizzi, Caterina

    2013-04-06

    This article concerns the design of lower limb prosthesis, both below and above knee. It describes a new computer-based design framework and a digital model of the patient around which the prosthesis is designed and tested in a completely virtual environment. The virtual model of the patient is the backbone of the whole system, and it is based on a biomechanical general-purpose model customized with the patient's characteristics (e.g. anthropometric measures). The software platform adopts computer-aided and knowledge-guided approaches with the goal of replacing the current development process, mainly hand made, with a virtual one. It provides the prosthetics with a set of tools to design, configure and test the prosthesis and comprehends two main environments: the prosthesis modelling laboratory and the virtual testing laboratory. The first permits the three-dimensional model of the prosthesis to be configured and generated, while the second allows the prosthetics to virtually set up the artificial leg and simulate the patient's postures and movements, validating its functionality and configuration. General architecture and modelling/simulation tools for the platform are described as well as main aspects and results of the experimentation.

  8. Computer-Aided Design of Nanocapsules for Therapeutic Delivery

    Directory of Open Access Journals (Sweden)

    Zeina Shreif

    2009-01-01

    Full Text Available The design of nanocapsules for targeted delivery of therapeutics presents many, often seemingly self-contradictory, constraints. An algorithm for predicting the physico-chemical characteristics of nanocapsule delivery and payload release using a novel all-atom, multiscale technique is presented. This computational method preserves key atomic-scale behaviours needed to make predictions of interactions of functionalized nanocapsules with the cell surface receptors, drug, siRNA, gene or other payload. We show how to introduce a variety of order parameters with distinct character to enable a multiscale analysis of a complex system. The all-atom formulation allows for the use of an interatomic force field, making the approach universal and avoiding recalibration with each new application. Alternatively, key parameters, which minimize the need for calibration, are also identified. Simultaneously, the methodology enables predictions of the supra-nanometer-scale behaviour, such as structural transitions and disassembly of the nanocapsule accompanying timed payload release or due to premature degradation. The final result is a Fokker–Planck equation governing the rate of stochastic payload release and structural changes and migration accompanying it. A novel “salt shaker” effect that underlies fluctuation-enhancement of payload delivery is presented. Prospects for computer-aided design of nanocapsule delivery system are discussed.

  9. Computer-aided drug design at Boehringer Ingelheim

    Science.gov (United States)

    Muegge, Ingo; Bergner, Andreas; Kriegl, Jan M.

    2016-09-01

    Computer-Aided Drug Design (CADD) is an integral part of the drug discovery endeavor at Boehringer Ingelheim (BI). CADD contributes to the evaluation of new therapeutic concepts, identifies small molecule starting points for drug discovery, and develops strategies for optimizing hit and lead compounds. The CADD scientists at BI benefit from the global use and development of both software platforms and computational services. A number of computational techniques developed in-house have significantly changed the way early drug discovery is carried out at BI. In particular, virtual screening in vast chemical spaces, which can be accessed by combinatorial chemistry, has added a new option for the identification of hits in many projects. Recently, a new framework has been implemented allowing fast, interactive predictions of relevant on and off target endpoints and other optimization parameters. In addition to the introduction of this new framework at BI, CADD has been focusing on the enablement of medicinal chemists to independently perform an increasing amount of molecular modeling and design work. This is made possible through the deployment of MOE as a global modeling platform, allowing computational and medicinal chemists to freely share ideas and modeling results. Furthermore, a central communication layer called the computational chemistry framework provides broad access to predictive models and other computational services.

  10. Application of Robust Design and Advanced Computer Aided Engineering Technologies: Cooperative Research and Development Final Report, CRADA Number CRD-04-143

    Energy Technology Data Exchange (ETDEWEB)

    Thornton, M.

    2013-06-01

    Oshkosh Corporation (OSK) is taking an aggressive approach to implementing advanced technologies, including hybrid electric vehicle (HEV) technology, throughout their commercial and military product lines. These technologies have important implications for OSK's commercial and military customers, including fleet fuel efficiency, quiet operational modes, additional on-board electric capabilities, and lower thermal signature operation. However, technical challenges exist with selecting the optimal HEV components and design to work within the performance and packaging constraints of specific vehicle applications. SK desires to use unique expertise developed at the Department of Energy?s (DOE) National Renewable Energy Laboratory (NREL), including HEV modeling and simulation. These tools will be used to overcome technical hurdles to implementing advanced heavy vehicle technology that meet performance requirements while improving fuel efficiency.

  11. Technology transfer of the Computer-Aided Prototyping System (CAPS)

    OpenAIRE

    Cooke, Robert P.

    1996-01-01

    The inability of the Department of Defense (DOD) to accurately and completely specify requirements for hard real-time software systems has resulted in poor productivity, schedule overruns, and software that is unmaintainable and unreliable. The Computer-Aided Prototyping System (CAPS) provides a capability to quickly develop functional prototypes to verify feasibility of system requirements early in the software development process. It was built to help program managers and software engineers...

  12. Computer-aided design of bromelain and papain covalent immobilization

    Directory of Open Access Journals (Sweden)

    Bessy Cutiño-Avila

    2014-06-01

    Full Text Available Título en español: Diseño asistido por computadora de la inmovilización covalente de bromelina y papaína.Título corto: Computer-aided design of bromelain and papain. Abstract: Enzymes as immobilized derivatives have been widely used in Food, Agrochemical, Pharmaceutical and Biotechnological industries. Protein immobilization is probably the most used technology to improve the operational stability of these molecules. Bromelain (Ananas comosus and papain (Carica papaya are cystein proteases extensively used as immobilized biocatalyst with several applications in therapeutics, racemic mixtures resolution, affinity chromatography and others industrial scenarios. The aim of this work was to optimize the covalent immobilization of bromelain and papain via rational design of immobilized derivatives strategy (RDID and RDID1.0 program. It was determined the maximum protein quantity to immobilize, the optimum immobilization pH (in terms of functional activity retention, and the most probable configuration of the immobilized derivative and the probabilities of multipoint covalent attachment was also predicted. As support material Glyoxyl-Sepharose CL 4B was used.  The accuracy of RDID1.0 program´s prediction was demonstrated comparing with experimental results. Bromelain and papain immobilized derivatives showed desired characteristics for industrial biocatalysis, such as: elevate pH stability retaining 95% and 100% residual activity at pH 7.0 and 8.0, for bromelain and papain, respectively; high thermal stability at 30 °C retaining 90% residual activity for both immobilized enzymes; a catalytic configuration bonded by immobilization at optimal pH; and the ligand load achieved, ensures the minimization of diffusional restrictions.Key words: bromelain, covalent immobilization, immobilized derivatives, papain, rational design.Resumen: Las enzimas inmovilizadas han sido ampliamente utilizadas en las industrias Alimentaria, Agroquímica, Farmac

  13. Laser imaging and computer-aided design and computer-aided manufacture in prosthetics and orthotics.

    Science.gov (United States)

    Spaeth, John P

    2006-02-01

    Although Hanger Orthopedic Group, Inc., has been developing clinical protocols for its INSIGNIA scanner for more than 2 years, there are many applications that are currently in development and will be released over the next 2-year period after this publication. It is the goal of Hanger Orthopedic Group, Inc., to replace all plaster casting procedures with the laser scan and move toward a paperless environment where all images and documents are passed through its virtual network. INSIGNIA currently has five major production centers throughout the United States, which support more than 600 INSIGNIA certified clinicians. These clinicians staff more than 600 clinics in North America, all under the Hanger company name. The central fabrication service and the central design center processes hundreds of shapes per day (Fig. 27). So that any clinician in the field can use the expertise of the central designers and central fabricators to help with overflow or problems they might be having, the network that exists within Hanger is tied together and enhanced by INSIGNIA. Through virtual modification and centralization of these services, each patient receives the virtual collaboration of several clinicians with a total of years of experience. INSIGNIA has enhanced the patient experience. The enhancement is not only in removing the plaster from the process, but also in exposing each patient to the team of prosthetic experts working collaboratively behind the scenes. The rehabilitation industry continues to be bombarded with compliance paperwork and justifications. The INSIGNIA scan and resulting measurement reports give inherent strength to justifications based on volume change, surgical revisions, or tissue change. The files are kept in a data warehouse where they are vaulted and preserved presumably forever. Also, any of the shape graphics or measurement instruments can be printed into a discrete report that can become part of the patient's permanent record. Many physicians

  14. Teaching Computer-Aided Design of Fluid Flow and Heat Transfer Engineering Equipment.

    Science.gov (United States)

    Gosman, A. D.; And Others

    1979-01-01

    Describes a teaching program for fluid mechanics and heat transfer which contains both computer aided learning (CAL) and computer aided design (CAD) components and argues that the understanding of the physical and numerical modeling taught in the CAL course is essential to the proper implementation of CAD. (Author/CMV)

  15. Enabling Lean Design Through Computer Aided Synthesis: The Injection Moulding Cooling Case

    NARCIS (Netherlands)

    Jauregui Becker, Juan M.; Wits, Wessel W.

    2015-01-01

    This paper explores the application of Computer Aided Synthesis (CAS) to support the implementation of Set-Based Concurrent Engineering (SBCE) and Just In Time Decision Making (JIT-DM), which are considered as two of the cornerstones of the Lean Design method. Computer Aided Synthesis refers to a ne

  16. Computer Aided Design of Polygalacturonase II from Aspergillus niger

    Directory of Open Access Journals (Sweden)

    Ibrahim Ali Noorbatcha

    2011-12-01

    Full Text Available Pectin is a complex polysaccharide found in the cell walls of plants and consisting mainly of esterified D-galacturonic acid resides in α-(1-4 chain. In production of fruit juice, pectin contributes to fruit juice viscosity, thereby reducing the juice production and increasing the filtration time. Polygalacturonase improves the juice production process by rapid degradation of pectin. In this project we have designed a novel polygalacturonase enzyme using computer aided design approaches. The three dimension structure of polygalacturonase is first modeled on the basis of the known crystal structure. The active site in this enzyme is identified by manual and automated docking methods. Lamarckian genetic algorithm is used for automated docking and the active site is validated by comparing with existing experimental data. This is followed by in silico mutations of the enzymes and the automated docking process is repeated using the mutant enzymes. The strength of the binding of the ligands inside the active site is evaluated by computing the binding score using Potential Mean Force (PMF method. The in silico mutations R256Q and K258N are found to decrease the binding strength of the ligand at the active site, indicating lowering of enzyme activity, which is consistent with the experimental results. Hence in silico mutations can be used to design new polygalacturonase enzymes with improved enzyme activity.ABSTRAK: Pektin adalah polisakarida kompleks yang terdapat di dalam dinding sel tumbuhan dan sebahagian besarnya terdiri daripada asid D-galakturonik terester yang ditemui di dalam rantaian α-(1-4. Dalam penghasilan jus buah-buahan, pektin menyumbang dalam kepekatan jus buah-buahan, di mana ia mengurangkan penghasilan jus dan menambahkan masa penapisan. Poligalakturonase meningkatkan proses penghasilan jus dengan pemecahan pektin dengan cepat. Dalam projek ini, kami telah merangka satu enzim poligalakturonase baru dengan menggunakan pendekatan reka

  17. Computer-aided Framework for Design of Pure, Mixed and Blended Products

    DEFF Research Database (Denmark)

    Cignitti, Stefano; Zhang, Lei; Gani, Rafiqul

    2015-01-01

    Design of novel chemical products with process and application considerations is an emerging topic in thefield of chemical and biochemical engineering. Methods, such as Computer Aided Molecular Design(CAMD) [1] and Computer-aided Mixture and Blend Design (CAMbD) [2], provide the possibility of de...... a solvent design case study.......Design of novel chemical products with process and application considerations is an emerging topic in thefield of chemical and biochemical engineering. Methods, such as Computer Aided Molecular Design(CAMD) [1] and Computer-aided Mixture and Blend Design (CAMbD) [2], provide the possibility...... of designing such products. However, these product design problems can quickly become large and difficult, if not infeasible, to solve through mathematical optimization. In addition, considerations of process,application, special product attributes, economic feasibility, environmental and sustainability...

  18. Micrometric precision of prosthetic dental crowns obtained by optical scanning and computer-aided designing/computer-aided manufacturing system

    Science.gov (United States)

    das Neves, Flávio Domingues; de Almeida Prado Naves Carneiro, Thiago; do Prado, Célio Jesus; Prudente, Marcel Santana; Zancopé, Karla; Davi, Letícia Resende; Mendonça, Gustavo; Soares, Carlos José

    2014-08-01

    The current study evaluated prosthetic dental crowns obtained by optical scanning and a computer-aided designing/computer-aided manufacturing system using micro-computed tomography to compare the marginal fit. The virtual models were obtained with four different scanning surfaces: typodont (T), regular impressions (RI), master casts (MC), and powdered master casts (PMC). Five virtual models were obtained for each group. For each model, a crown was designed on the software and milled from feldspathic ceramic blocks. Micro-CT images were obtained for marginal gap measurements and the data were statistically analyzed by one-way analysis of variance followed by Tukey's test. The mean vertical misfit was T=62.6±65.2 μm; MC=60.4±38.4 μm; PMC=58.1±38.0 μm, and RI=89.8±62.8 μm. Considering a percentage of vertical marginal gap of up to 75 μm, the results were T=71.5%, RI=49.2%, MC=69.6%, and PMC=71.2%. The percentages of horizontal overextension were T=8.5%, RI=0%, MC=0.8%, and PMC=3.8%. Based on the results, virtual model acquisition by scanning the typodont (simulated mouth) or MC, with or without powder, showed acceptable values for the marginal gap. The higher result of marginal gap of the RI group suggests that it is preferable to scan this directly from the mouth or from MC.

  19. Model-based computer-aided design for controlled release of pesticides

    DEFF Research Database (Denmark)

    Muro Sunè, Nuria; Gani, Rafiqul; Bell, G.;

    2005-01-01

    In the field of controlled release technology for pesticides or active ingredients (AI), models that can predict its delivery during application are important for purposes of design and marketing of the pesticide product. Appropriate models for the controlled release of pesticides, if available, ...... extended models have been developed and implemented into a computer-aided system. The total model consisting of the property models embedded into the release models are then employed to study the release of different combinations of AIs and polymer-based microcapsules....

  20. Fracture resistance of computer-aided design/computer-aided manufacturing-generated composite resin-based molar crowns.

    Science.gov (United States)

    Harada, Akio; Nakamura, Keisuke; Kanno, Taro; Inagaki, Ryoichi; Örtengren, Ulf; Niwano, Yoshimi; Sasaki, Keiichi; Egusa, Hiroshi

    2015-04-01

    The aim of this study was to investigate whether different fabrication processes, such as the computer-aided design/computer-aided manufacturing (CAD/CAM) system or the manual build-up technique, affect the fracture resistance of composite resin-based crowns. Lava Ultimate (LU), Estenia C&B (EC&B), and lithium disilicate glass-ceramic IPS e.max press (EMP) were used. Four types of molar crowns were fabricated: CAD/CAM-generated composite resin-based crowns (LU crowns); manually built-up monolayer composite resin-based crowns (EC&B-monolayer crowns); manually built-up layered composite resin-based crowns (EC&B-layered crowns); and EMP crowns. Each type of crown was cemented to dies and the fracture resistance was tested. EC&B-layered crowns showed significantly lower fracture resistance compared with LU and EMP crowns, although there was no significant difference in flexural strength or fracture toughness between LU and EC&B materials. Micro-computed tomography and fractographic analysis showed that decreased strength probably resulted from internal voids in the EC&B-layered crowns introduced by the layering process. There was no significant difference in fracture resistance among LU, EC&B-monolayer, and EMP crowns. Both types of composite resin-based crowns showed fracture loads of >2000 N, which is higher than the molar bite force. Therefore, CAD/CAM-generated crowns, without internal defects, may be applied to molar regions with sufficient fracture resistance. © 2015 Eur J Oral Sci.

  1. Predictable Restorative Work Flow for Computer-Aided Design/Computer-Aided Manufacture-Fabricated Ceramic Veneers Utilizing a Virtual Smile Design Principle.

    Science.gov (United States)

    Lin, W S; Zandinejad, A; Metz, M J; Harris, B T; Morton, D

    2015-01-01

    The purpose of this case report was to present the use of a contemporary digital photograph-assisted virtual smile design principle, an intraoral digital impression, and computer-aided design/computer-aided manufacture-fabricated lithium disilicate ceramic veneers to treat a patient with esthetic needs in the maxillary anterior region. By using the proposed digital restorative work flow, this case report demonstrated an effective communication pathway between the patient, clinician, and dental laboratory technician. Effective communication can help to achieve a more predictable and satisfactory esthetic outcome.

  2. Computer-aided Framework for Design of Pure, Mixed and Blended Products

    DEFF Research Database (Denmark)

    2015-01-01

    This paper presents a framework for computer-aided design of pure, mixed and blended chemical based products. The framework is a systematic approach to convert a Computer-aided Molecular, Mixture and Blend Design (CAMbD) formulation, based on needs and target properties, into a mixed integer non-......-linear program (MINLP). TheMINLP is sequentially solved through a decomposed optimization approach to solve the possibly large MINLP in a smaller set of sub-problems. The framework application is highlighted through a solvent design case study.......This paper presents a framework for computer-aided design of pure, mixed and blended chemical based products. The framework is a systematic approach to convert a Computer-aided Molecular, Mixture and Blend Design (CAMbD) formulation, based on needs and target properties, into a mixed integer non...

  3. Computer-aided technology for fabricating complete dentures: systematic review of historical background, current status, and future perspectives.

    Science.gov (United States)

    Bidra, Avinash S; Taylor, Thomas D; Agar, John R

    2013-06-01

    Computer-aided technology is an emerging method for fabricating complete dentures. Consolidated information about historical background, current status, and scope for the future is lacking. The purpose of this systematic review was to analyze the existing literature on computer-aided technology for fabricating complete dentures and provide the reader with a historical background, current status, and future perspectives on this emerging technology. An electronic search of the English language literature between the periods of January 1957 and June 2012 was performed by using PubMed/MEDLINE with the following specific search terms: CAD-CAM complete dentures, digital complete dentures, computer dentures, designed dentures, machined dentures, manufactured dentures, milled dentures, and rapid prototyping dentures. Additionally, the search terms were used on the Google search engine to identify current commercial manufacturers and their protocols. A total of 1584 English language titles were obtained from the electronic database, and the systematic application of exclusion criteria resulted in the identification of 8 articles pertaining to computer-aided technology for complete dentures. Since the first published report in 1994, multiple authors have described different theoretical models and protocols for fabricating complete dentures with computer-aided technology. Although no clinical trials or clinical reports were identified in the scientific literature, the Google search engine identified 2 commercial manufacturers in the United States currently fabricating complete dentures with computer-aided design and computer-aided manufacturing (CAD/CAM) technology for clinicians world-wide. These manufacturers have definitive protocols in place and offer exclusive dental materials, techniques, and laboratory support. Their protocols contrast with conventional paradigms for fabricating complete dentures and allow the fabrication of complete dentures in 2 clinical appointments

  4. Fabrication of tissue engineered tympanic membrane patches using computer-aided design and injection molding.

    Science.gov (United States)

    Hott, Morgan E; Megerian, Cliff A; Beane, Rich; Bonassar, Lawrence J

    2004-07-01

    The goal of the current study was to use computer-aided design and injection molding technologies to tissue engineer precisely shaped cartilage in the shape of butterfly tympanic membrane patches out of chondrocyte-seeded calcium alginate gels. Molds were designed on SolidWorks 2000 and built out of acrylonitrile butadiene styrene (ABS) using fused deposition modeling (FDM). Tympanic membrane patches were fabricated using bovine articular chondrocytes seeded at 50 x 10 cells/mL in 2% calcium alginate gels. Molded patches were cultured in vitro for up to 10 weeks and assessed biochemically, morphologically, and histologically. Unmolded patches demonstrated outstanding dimensional fidelity, with a volumetric precision of at least 3 microL, and maintained their shape well for up to 10 weeks of in vitro culture. Glycosaminoglycan and collagen content increased steadily over 10 weeks in culture, demonstrating continual deposition of new extracellular matrix consistent with new tissue development. The use of computer-aided design and injection molding technologies allows for the fabrication of very small, precisely shaped chondrocyte-seeded calcium alginate structures that faithfully maintain their shape during in vitro culture. In vitro fabrication of tympanic membrane patches with a precisely controlled geometry may have the potential to provide a minimally invasive alternative to traditional methods for the repair of chronic tympanic membrane perforations.

  5. Computer aided design of microcircuits. Citations from the NTIS data base

    Science.gov (United States)

    Reed, W. E.

    1980-09-01

    Government sponsored research covering the computer aided design, modeling, layout, and packaging of integrated and other microelectronic circuits are cited. Computer programs and the use of computer graphics are included.

  6. Computer-aided Detection of Prostate Cancer with MRI: Technology and Applications.

    Science.gov (United States)

    Liu, Lizhi; Tian, Zhiqiang; Zhang, Zhenfeng; Fei, Baowei

    2016-08-01

    One in six men will develop prostate cancer in his lifetime. Early detection and accurate diagnosis of the disease can improve cancer survival and reduce treatment costs. Recently, imaging of prostate cancer has greatly advanced since the introduction of multiparametric magnetic resonance imaging (mp-MRI). Mp-MRI consists of T2-weighted sequences combined with functional sequences including dynamic contrast-enhanced MRI, diffusion-weighted MRI, and magnetic resonance spectroscopy imaging. Because of the big data and variations in imaging sequences, detection can be affected by multiple factors such as observer variability and visibility and complexity of the lesions. To improve quantitative assessment of the disease, various computer-aided detection systems have been designed to help radiologists in their clinical practice. This review paper presents an overview of literatures on computer-aided detection of prostate cancer with mp-MRI, which include the technology and its applications. The aim of the survey is threefold: an introduction for those new to the field, an overview for those working in the field, and a reference for those searching for literature on a specific application.

  7. Computer-Aided Chemical Product Design Framework: Design of High Performance and Environmentally Friendly Refrigerants

    DEFF Research Database (Denmark)

    Cignitti, Stefano; Zhang, Lei; Gani, Rafiqul

    a driving force for the industry to continuously seek novel refrigerants as current refrigerants risk phasing out due to environmental regulations. This trend has been seen since the Kyoto Protocol in 1997 and recently from the EU regulations from 2014, which will restrict the use of some known refrigerants...... properties and needs should carefully be selected for a given heat pump cycle to ensure that an optimum refrigerant is found? How can cycle performance and environmental criteria be integrated at the product design stage and not in post-design analysis? Computer-aided product design methods enable...... the possibility of designing novel molecules, mixtures and blends, such as refrigerants through a systematic framework (Cignitti et al., 2015; Yunus et al., 2014). In this presentation a computer-aided framework is presented for chemical product design through mathematical optimization. Here, molecules, mixtures...

  8. Computer-Aided Vaccine Design: A Brief Report

    Directory of Open Access Journals (Sweden)

    R Ghasemi Khorasgani

    2012-09-01

    Full Text Available Background: Although the conventional vaccines have been instrumented in the incidence of many infectious diseases, the advances in genetic engineering and bioinformatics have provided the opportunity for developing improved and new vaccines.Methods: Reverse vaccinology was pioneered by a group of researchers investigating development of a vaccine against serogroup B Neisseria meningitidis. Reverse vaccinology analyzes the entire genome of a pathogen with the aid of computational programs to identify potentially antigenic extracellular proteins.Results: Using this method for Neisseria meningitidis genome analysis, 600 secretory or surface-exposed proteins were identified and, subsequently, 350 proteins were expressed and purified. Finally, seven proteins capable of activating the immune system against a range of strains were identified.Conclusion: Improved computational techniques are now able to provide researchers with high-confidence predictions for complex biological characteristics. This will herald a move to computer-aided biotechnology in which time-consuming and expensive large-scale experimental approaches are progressively replaced by functional bioinformatic investigations.

  9. Simultaneous Computer-Aided Design/Computer-Aided Manufacture Bimaxillary Orthognathic Surgery and Mandibular Reconstruction Using Selective-Laser Sintered Titanium Implant.

    Science.gov (United States)

    Hatamleh, Muhanad M; Bhamrah, Gurprit; Ryba, Francine; Mack, Gavin; Huppa, Chrisopher

    2016-10-01

    This patient report describes simultaneous bimaxillary orthognathic surgery and mandibular reconstruction by means of three-dimensional (3D) planning, 3D printed biocompatible surgical wafers, and 3D selective-laser sintered titanium implant. A 26-year-old male patient presented with a left mandibular defect secondary to trauma. The whole body of the mandible on the left hand side was deficient with a narrow connection with the remaining left condyle. He had undergone orthodontic treatment for 18 months and was ready to undergo bimaxillary orthognathic surgery. Advanced cranio-maxillofacial software was used in processing his cone beam computer tomography scan data, and e-casts of his upper and lower dental arches. Bimaxillary surgery was planned with Le Fort 1 maxillary impaction and mandibular advancement to achieve a class 1 incisor relationship. Intermediate and final surgical wafers were designed following the planned movements and printed using biocompatible resin. The deficient left side of the mandible was reconstructed by means of mirror imaging the contra-lateral right side into the deficient left side with the aim of restoring normal facial symmetry. Biomedical software was then used in designing a reconstruction plate that connected the condylar head and the mandible following the planned bimaxillary surgery and mandibular continuity symmetry reconstruction. The plate was printed in titanium following state-of the-art selective laser sintering technology. The bimaxillary surgery and mandibular reconstruction were done simultaneously as planned along with an iliac-crest bone graft. This patient confirms the advantages of 3D computer-aided design/computer-aided manufacture technologies in optimizing clinical outcomes for cranio-maxillofacial reconstruction, especially when conducting two simultaneous clinical procedures.

  10. Computer Aided Design of a Hyper-redundant Manipulator

    Directory of Open Access Journals (Sweden)

    MARGHITU, D.

    2013-11-01

    Full Text Available Bioinspired solution can support significant improvements across various fields of robotics, offering solutions to basic problems such as locomotion and manipulation in unstructured environments. This paper deals with the problem of using a bioinspired solution in building a hyper-redundant robotic arm. In the recent period, were developed an important number of application using like an octopus or like snake or like a trunk of elephant solutions for robotic arms. Such kind of projects must solve difficult problems on the way from design to implementation. The problems are mainly linked with the actuation solution, with the control of the structure, with sensors to close the control loop, technology for the implementation. In this paper we focus on the process of modelling, simulating, and designing of hyper-redundant robotic arm.

  11. The Research of Computer Aided Farm Machinery Designing Method Based on Ergonomics

    Science.gov (United States)

    Gao, Xiyin; Li, Xinling; Song, Qiang; Zheng, Ying

    Along with agricultural economy development, the farm machinery product type Increases gradually, the ergonomics question is also getting more and more prominent. The widespread application of computer aided machinery design makes it possible that farm machinery design is intuitive, flexible and convenient. At present, because the developed computer aided ergonomics software has not suitable human body database, which is needed in view of farm machinery design in China, the farm machinery design have deviation in ergonomics analysis. This article puts forward that using the open database interface procedure in CATIA to establish human body database which aims at the farm machinery design, and reading the human body data to ergonomics module of CATIA can product practical application virtual body, using human posture analysis and human activity analysis module to analysis the ergonomics in farm machinery, thus computer aided farm machinery designing method based on engineering can be realized.

  12. Research on the Procedure for Computer-Aided Pattern Design of Uygur's Flowered Hats

    Directory of Open Access Journals (Sweden)

    Shuxian Liu

    2013-05-01

    Full Text Available Xinjiang Uygur’s flowered hats is famous all over the world, it leads the world of headwear of variou nationalities within China by the variety of styles, the various ways of how to emroider pattern design and exquisite manufacture. It is unusual even in national costumes art of the world. The poupose of this study is to analyze Uygur's headwear, study the rules of Uygur's headwear pattern, analyze the characteristic of the basic pattern, research on the procedure for computer-aided pattern design of Uygur's flowered hat, explore the application of computer-aided design in traditional costume's pattern design and to realize application exploration of computer-aided design in designing of costume and dress adornment.

  13. Integrated Computer Aided Planning and Manufacture of Advanced Technology Jet Engines

    Directory of Open Access Journals (Sweden)

    B. K. Subhas

    1987-10-01

    Full Text Available This paper highlights an attempt at evolving a computer aided manufacturing system on a personal computer. A case study of an advanced technology jet engine component is included to illustrate various outputs from the system. The proposed system could be an alternate solution to sophisticated and expensive CAD/CAM workstations.

  14. A Multi-step and Multi-level approach for Computer Aided Molecular Design

    DEFF Research Database (Denmark)

    A general multi-step approach for setting up, solving and solution analysis of computer aided molecular design (CAMD) problems is presented. The approach differs from previous work within the field of CAMD since it also addresses the need for a computer aided problem formulation and result analysis....... The problem formulation step incorporates a knowledge base for the identification and setup of the design criteria. Candidate compounds are identified using a multi-level generate and test CAMD solution algorithm capable of designing molecules having a high level of molecular detail. A post solution step...... using an Integrated Computer Aided System (ICAS) for result analysis and verification is included in the methodology. Keywords: CAMD, separation processes, knowledge base, molecular design, solvent selection, substitution, group contribution, property prediction, ICAS Introduction The use of Computer...

  15. From chemical graphs in computer-aided drug design to general Markov-Galvez indices of drug-target, proteome, drug-parasitic disease, technological, and social-legal networks.

    Science.gov (United States)

    Riera-Fernández, Pablo; Munteanu, Cristian R; Dorado, Julian; Martin-Romalde, Raquel; Duardo-Sanchez, Aliuska; González-Diaz, Humberto

    2011-12-01

    Complex Networks are useful in solving problems in drug research and industry, developing mathematical representations of different systems. These systems move in a wide range from relatively simple graph representations of drug molecular structures to large systems. We can cite for instance, drug-target protein interaction networks, drug policy legislation networks, or drug treatment in large geographical disease spreading networks. In any case, all these networks have essentially the same components: nodes (atoms, drugs, proteins, microorganisms and/or parasites, geographical areas, drug policy legislations, etc.) and edges (chemical bonds, drug-target interactions, drug-parasite treatment, drug use, etc.). Consequently, we can use the same type of numeric parameters called Topological Indices (TIs) to describe the connectivity patterns in all these kinds of Complex Networks despite the nature of the object they represent. The main reason for this success of TIs is the high flexibility of this theory to solve in a fast but rigorous way many apparently unrelated problems in all these disciplines. Another important reason for the success of TIs is that using these parameters as inputs we can find Quantitative Structure-Property Relationships (QSPR) models for different kind of problems in Computer-Aided Drug Design (CADD). Taking into account all the above-mentioned aspects, the present work is aimed at offering a common background to all the manuscripts presented in this special issue. In so doing, we make a review of the most common types of complex networks involving drugs or their targets. In addition, we review both classic TIs that have been used to describe the molecular structure of drugs and/or larger complex networks. Next, we use for the first time a Markov chain model to generalize Galvez TIs to higher order analogues coined here as the Markov-Galvez TIs of order k (MGk). Lastly, we illustrate the calculation of MGk values for different classes of

  16. Computer-aided design of microvasculature systems for use in vascular scaffold production

    Energy Technology Data Exchange (ETDEWEB)

    Mondy, William Lafayette [Department of Chemical and Biomedical Engineering, University of South Florida, FL (United States); Cameron, Don [Department of Pathology and Cell Biology, College of Medicine, University of South Florida, FL (United States); Timmermans, Jean-Pierre [Department of Veterinary Sciences, University of Antwerp (Belgium); De Clerck, Nora [Department of Biomedical Sciences University of Antwerp (Belgium); Sasov, Alexander [Skyscan (Belgium); Casteleyn, Christophe [College of Veterinary Medicine, Ghent University (Belgium); Piegl, Les A [Department of Computer Science and Engineering, University of South Florida, FL (United States)

    2009-09-15

    In vitro biomedical engineering of intact, functional vascular networks, which include capillary structures, is a prerequisite for adequate vascular scaffold production. Capillary structures are necessary since they provide the elements and compounds for the growth, function and maintenance of 3D tissue structures. Computer-aided modeling of stereolithographic (STL) micro-computer tomographic (micro-CT) 3D models is a technique that enables us to mimic the design of vascular tree systems containing capillary beds, found in tissues. In our first paper (Mondy et al 2009 Tissue Eng. at press), using micro-CT, we studied the possibility of using vascular tissues to produce data capable of aiding the design of vascular tree scaffolding, which would help in the reverse engineering of a complete vascular tree system including capillary bed structures. In this paper, we used STL models of large datasets of computer-aided design (CAD) data of vascular structures which contained capillary structures that mimic those in the dermal layers of rabbit skin. Using CAD software we created from 3D STL models a bio-CAD design for the development of capillary-containing vascular tree scaffolding for skin. This method is designed to enhance a variety of therapeutic protocols including, but not limited to, organ and tissue repair, systemic disease mediation and cell/tissue transplantation therapy. Our successful approach to in vitro vasculogenesis will allow the bioengineering of various other types of 3D tissue structures, and as such greatly expands the potential applications of biomedical engineering technology into the fields of biomedical research and medicine.

  17. Computer-Aided Design, Modeling and Simulation of a New Solar Still Design

    Directory of Open Access Journals (Sweden)

    Jeremy (Zheng Li

    2011-01-01

    Full Text Available The clean and pure drinking water is important in today's life but current water sources are usually brackish with bacteria that cannot be used for drinking. About 78% of water available in the sea is salty, 21% of water is brackish, and only 1% of water is fresh. Distillation is one of the feasible processes applied to water purification, and it requires the energy inputs, such as solar radiation. Water is evaporated in this distillation process and water vapor can be separated and condensed to pure water. Now, with the change from conventional fuels to renewable and environment friendly fuels sources, the modern technology allows to use the abundant energy from the sun. It is better to use solar energy to process the water desalination since it is more economical than the use of conventional energies. The main focus of this paper is applying computer-aided modeling and simulation to design a less complex solar water distillation system. The prototype of this solar still system is also built to verify its feasibility, functionality, and reliability. The computational simulation and prototype testing show the reliability and proper functionality of this solar water distillation system.

  18. Computer aided process planning system based on workflow technology and integrated bill of material tree

    Institute of Scientific and Technical Information of China (English)

    LU Chun-guang; MENG Li-li

    2006-01-01

    It is extremely important for procedure of process design and management of process data for product life cycle in Computer Aided Process Planning (CAPP) system,but there are many shortcomings with traditional CAPP system in these respects.To solve these questions,application of workflow technology in CAPP system based on web-integrated Bill of Material (BOM) tree is discussed,and a concept of integrated BOM tree was brought forward.Taking integrated BOM as the thread,CAPP systematic technological process is analyzed.The function,system architecture,and implementation mechanism of CAPP system based on Browser/Server and Customer/Server model are expatiated.Based on it,the key technologies of workflow management device were analyzed.Eventually,the implementation mechanism of integrated BOM tree was analyzed from viewpoints of material information encoding,organization node design of integrated BOM tree,transformation from Engineering BOM (EBOM)to Process BOM (PBOM),and the programming implementation technology.

  19. Energy-aware memory management for embedded multimedia systems a computer-aided design approach

    CERN Document Server

    Balasa, Florin

    2011-01-01

    Energy-Aware Memory Management for Embedded Multimedia Systems: A Computer-Aided Design Approach presents recent computer-aided design (CAD) ideas that address memory management tasks, particularly the optimization of energy consumption in the memory subsystem. It explains how to efficiently implement CAD solutions, including theoretical methods and novel algorithms. The book covers various energy-aware design techniques, including data-dependence analysis techniques, memory size estimation methods, extensions of mapping approaches, and memory banking approaches. It shows how these techniques

  20. The application of computer-aided designated titanium mesh in repairing skull defects

    Directory of Open Access Journals (Sweden)

    Lei ZHANG

    2015-01-01

    Full Text Available Objective To explore the clinical value of repairing skull defects with titanium alloy-mesh of computer-aided design.  Methods A retrospective analysis was done on clinical data of 86 cases with skull defects who underwent repairing using titanium mesh with two-dimensional or three-dimensional computer-aided design.  Results All the incisions achieved primary healing other than one case conducting reoperation due to exposed titanium mesh. Two cases got subcutaneous exudate, one obtained painful mastication and one experienced proliferation of scalp scar.  Conclusions With the computer-aided designated titanium mesh, relevant operation can resume the original state to maximum extent, lower surgical risk, decrease post-operational complications and then obtain satisfying clinical effect. DOI: 10.3969/j.issn.1672-6731.2015.01.015

  1. Computer Aided Design in Digital Human Modeling for Human Computer Interaction in Ergonomic Assessment: A Review

    Directory of Open Access Journals (Sweden)

    Suman Mukhopadhyay , Sanjib Kumar Das and Tania Chakraborty

    2012-12-01

    Full Text Available Research in Human-Computer Interaction (HCI hasbeen enormously successful in the area of computeraidedergonomics or human-centric designs. Perfectfit for people has always been a target for productdesign. Designers traditionally used anthropometricdimensions for 3D product design which created a lotof fitting problems when dealing with thecomplexities of the human body shapes. Computeraided design (CAD, also known as Computer aideddesign and drafting (CADD is the computertechnology used for the design processing and designdocumentation. CAD has now been used extensivelyin many applications such as automotive,shipbuilding, aerospace industries, architectural andindustrial designs, prosthetics, computer animationfor special effects in movies, advertising andtechnical manuals. As a technology, digital humanmodeling (DHM has rapidly emerged as atechnology that creates, manipulates and controlhuman representations and human-machine systemsscenes on computers for interactive ergonomic designproblem solving. DHM promises to profoundlychange how products or systems are designed, howergonomics analysis is performed, how disorders andimpairments are assessed and how therapies andsurgeries are conducted. The imperative andemerging need for the DHM appears to be consistentwith the fact that the past decade has witnessedsignificant growth in both the software systemsoffering DHM capabilities as well as the corporateadapting the technology.The authors shall dwell atlength and deliberate on how research in DHM hasfinally brought about an enhanced HCI, in thecontext of computer-aided ergonomics or humancentricdesign and discuss about future trends in thiscontext.

  2. Computer-Aided Model Based Analysis for Design and Operation of a Copolymerization Process

    DEFF Research Database (Denmark)

    Lopez-Arenas, Maria Teresa; Sales-Cruz, Alfonso Mauricio; Gani, Rafiqul

    2006-01-01

    The advances in computer science and computational algorithms for process modelling, process simulation, numerical methods and design/synthesis algorithms, makes it advantageous and helpful to employ computer-aided modelling systems and tools for integrated process analysis. This is illustrated....... This will allow analysis of the process behaviour, contribute to a better understanding of the polymerization process, help to avoid unsafe conditions of operation, and to develop operational and optimizing control strategies. In this work, through a computer-aided modeling system ICAS-MoT, two first......, the process design and conditions of operation on the polymer grade and the production rate....

  3. Computer Aided Design of Kaplan Turbine Piston with\tSolidWorks

    Directory of Open Access Journals (Sweden)

    Camelia Jianu

    2010-10-01

    Full Text Available The paper presents the steps for 3D computer aided design (CAD of Kaplan turbine piston made in SolidWorks.The present paper is a tutorial for a Kaplan turbine piston 3D geometry, which is dedicaded to the Parts Sketch and Parts Features design and Drawing Geometry and Drawing Annotation.

  4. COMPUTER AIDED THREE DIMENSIONAL DESIGN OF MOLD COMPONENTS

    Directory of Open Access Journals (Sweden)

    Kerim ÇETİNKAYA

    2000-02-01

    Full Text Available Sheet metal molding design with classical methods is formed in very long times calculates and drafts. At the molding design, selection and drafting of most of the components requires very long time because of similar repetative processes. In this study, a molding design program has been developed by using AutoLISP which has been adapted AutoCAD packet program. With this study, design of sheet metal molding, dimensioning, assemly drafting has been realized.

  5. Computer-aided design of stripline ferrite junction circulators

    Science.gov (United States)

    Uzdy, Z.

    1980-01-01

    A general design procedure is presented for stripline Y-junction circulators employing solid dielectric between ground planes. The resonator design and impedance matching are derived in a form suitable for computer evaluation. The procedure is applicable to cases where either the circulator bandwidth or the ground plane spacing is specified. An experimental S-band switching circulator design illustrates the technique.

  6. APPLICATION OF INFORMATION AND COMMUNICATION TECHNOLOGIES IN COMPUTER AIDED LANGUAGE LEARNING

    Directory of Open Access Journals (Sweden)

    I. B. Tampel

    2013-01-01

    Full Text Available The article deals with the various ways of application for automatic speech recognition, Text-to-Speech technology, pronunciation and communication skills training, vocabulary check of the taught person, audition skills training in computer aided language learning (CALL-system. In spite of some constraints such technologies application is effective both for education problems simplification and for comfort growth of the system application.

  7. A digital patient for computer-aided prosthesis design

    OpenAIRE

    Colombo, Giorgio; Facoetti, Giancarlo; Rizzi, Caterina

    2013-01-01

    This article concerns the design of lower limb prosthesis, both below and above knee. It describes a new computer-based design framework and a digital model of the patient around which the prosthesis is designed and tested in a completely virtual environment. The virtual model of the patient is the backbone of the whole system, and it is based on a biomechanical general-purpose model customized with the patient's characteristics (e.g. anthropometric measures). The software platform adopts com...

  8. Computer Aided Flowsheet Design using Group Contribution Methods

    DEFF Research Database (Denmark)

    Bommareddy, Susilpa; Eden, Mario R.; Gani, Rafiqul

    In this paper, a systematic group contribution based framework is presented for synthesis of process flowsheets from a given set of input and output specifications. Analogous to the group contribution methods developed for molecular design, the framework employs process groups to represent...... information of each flowsheet to minimize the computational load and information storage. The design variables for the selected flowsheet(s) are identified through a reverse simulation approach and are used as initial estimates for rigorous simulation to verify the feasibility and performance of the design....

  9. Computer-aided synthesis and design of plant utility systems

    Energy Technology Data Exchange (ETDEWEB)

    Petroulas, T.; Reklaitis, G.V.

    1984-01-01

    A design synthesis procedure is developed for preliminary design of utility systems. Given known steam sources (waste heat and auxiliary boilers) and sinks (heating, process injection, and driver horsepower needs), the algorithm determines the optimal header pressure levels, the distribution of steam turbines in the network, and the steam flows between all devices so as to maximize the real work recovered from the sources. Any number of pressure levels can be accommodated at only modest increase in computational effort.

  10. Computer aided die design: A new open-source methodology

    Science.gov (United States)

    Carneiro, Olga Sousa; Rajkumar, Ananth; Ferrás, Luís Lima; Fernandes, Célio; Sacramento, Alberto; Nóbrega, João Miguel

    2017-05-01

    In this work we present a detailed description of how to use open source based computer codes to aid the design of complex profile extrusion dies, aiming to improve its flow distribution. The work encompasses the description of the overall open-source die design methodology, the implementation of the energy conservation equation in an existing OpenFOAM® solver, which will be then capable of simulating the steady non-isothermal flow of an incompressible generalized Newtonian fluid, and two case studies to illustrate the capabilities and practical usefulness of the developed methodology. The results obtained with these case studies, used to solve real industrial problems, demonstrate that the computational design aid is an excellent alternative, from economical and technical points of view, to the experimental trial-and-error procedure commonly used in industry.

  11. Computer-Aided Sustainable Process Synthesis-Design and Analysis

    DEFF Research Database (Denmark)

    Kumar Tula, Anjan

    Process synthesis involves the investigation of chemical reactions needed to produce the desired product, selection of the separation techniques needed for downstream processing, as well as taking decisions on sequencing the involved separation operations. For an effective, efficient and flexible...... purity etc. In this way, the entire list of feasible chemical process flowsheets are quickly generated, screened and selected for further analysis. In the next stage, the design of the most promising process flowsheet candidates is performed through a reverse simulation approach, where the design...

  12. The computer-aided design of a servo system as a multiple-criteria decision problem

    NARCIS (Netherlands)

    Udink ten Cate, A.J.

    1986-01-01

    This paper treats the selection of controller gains of a servo system as a multiple-criteria decision problem. In contrast to the usual optimization-based approaches to computer-aided design, inequality constraints are included in the problem as unconstrained objectives. This considerably simplifies

  13. Gathering Empirical Evidence Concerning Links between Computer Aided Design (CAD) and Creativity

    Science.gov (United States)

    Musta'amal, Aede Hatib; Norman, Eddie; Hodgson, Tony

    2009-01-01

    Discussion is often reported concerning potential links between computer-aided designing and creativity, but there is a lack of systematic enquiry to gather empirical evidence concerning such links. This paper reports an indication of findings from other research studies carried out in contexts beyond general education that have sought evidence…

  14. Computer aided molecular design with combined molecular modeling and group contribution

    DEFF Research Database (Denmark)

    Harper, Peter Mathias; Gani, Rafiqul; Kolar, Petr

    1999-01-01

    Computer-aided molecular design (CAMD) provides a means for determining molecules or mixtures of molecules (CAMMD) having a desirable set of physicochemical properties. The application range of CAMD is restricted due to limitations on the complexity of the generated molecular structures and on th...

  15. Design Theory of Intellectualized Computer Aided Instruction and Its Applications

    Institute of Scientific and Technical Information of China (English)

    CUI Hong-bin; WANG Ai-min; YU Dong-mei

    2001-01-01

    This paper presents design theory and method of the intellectualized CAI. which includes the organization and expression of the teaching content and the teaching requirement determination in teaching process, and develops a highly intellectualized CA1 software. LA-CAI, to use for liner arithmetic teaching program.

  16. Computer Aided Flowsheet Design using Group Contribution Methods

    DEFF Research Database (Denmark)

    Bommareddy, Susilpa; Eden, Mario R.; Gani, Rafiqul

    In this paper, a systematic group contribution based framework is presented for synthesis of process flowsheets from a given set of input and output specifications. Analogous to the group contribution methods developed for molecular design, the framework employs process groups to represent...

  17. Computer Aided Flowsheet Design using Group Contribution Methods

    DEFF Research Database (Denmark)

    Bommareddy, Susilpa; Eden, Mario R.; Gani, Rafiqul

    2011-01-01

    In this paper, a systematic group contribution based framework is presented for synthesis of process flowsheets from a given set of input and output specifications. Analogous to the group contribution methods developed for molecular design, the framework employs process groups to represent...

  18. Computer-Aided Analysis of Patents for Product Technology Maturity Forecasting

    Science.gov (United States)

    Liang, Yanhong; Gan, Dequan; Guo, Yingchun; Zhang, Peng

    Product technology maturity foresting is vital for any enterprises to hold the chance for innovation and keep competitive for a long term. The Theory of Invention Problem Solving (TRIZ) is acknowledged both as a systematic methodology for innovation and a powerful tool for technology forecasting. Based on TRIZ, the state -of-the-art on the technology maturity of product and the limits of application are discussed. With the application of text mining and patent analysis technologies, this paper proposes a computer-aided approach for product technology maturity forecasting. It can overcome the shortcomings of the current methods.

  19. Computer-Aided Design Models to Support Ergonomics

    Science.gov (United States)

    1985-12-01

    LABORATORY 4 WILLIAM B. ASKREN AIR FORCE HUMAN RESOURCES LABORA7IJRY LEC OCT 2 2 DECEMBER 1985 Apprw. edfor public release, distributionz is...SUPPORT ERGONOMICS (U) .__ _ _ _ _ 12. PERSONAL AUTHOR(S) McDaniel, Joe W. and Askren, William B.* ". k % 13.. TYPE OF REPORT 13b. TIME COVERED 14...technician which the designer can effectively use for maintainability analyses. ,% 4,1’ 12.. 6- - p *. **, . k % ... APPROACH v There are three elements to

  20. Computer-aided design of DNA origami structures.

    Science.gov (United States)

    Selnihhin, Denis; Andersen, Ebbe Sloth

    2015-01-01

    The DNA origami method enables the creation of complex nanoscale objects that can be used to organize molecular components and to function as reconfigurable mechanical devices. Of relevance to synthetic biology, DNA origami structures can be delivered to cells where they can perform complicated sense-and-act tasks, and can be used as scaffolds to organize enzymes for enhanced synthesis. The design of DNA origami structures is a complicated matter and is most efficiently done using dedicated software packages. This chapter describes a procedure for designing DNA origami structures using a combination of state-of-the-art software tools. First, we introduce the basic method for calculating crossover positions between DNA helices and the standard crossover patterns for flat, square, and honeycomb DNA origami lattices. Second, we provide a step-by-step tutorial for the design of a simple DNA origami biosensor device, from schematic idea to blueprint creation and to 3D modeling and animation, and explain how careful modeling can facilitate later experimentation in the laboratory.

  1. A basic tool for computer-aided sail design

    Energy Technology Data Exchange (ETDEWEB)

    Thrasher, D.F.; Dunyak, T.J.; Mook, D.T.; Nayfeh, A.H. [Virginia Polytechnic Inst. and State Univ., Dept. of Engineering Science and Mechanics, Blacksburg, Virginia (Canada)

    1985-07-01

    Recent developments in modelling lifting surfaces have provided a tool that also can be used to model sails. The simplest of the adequate models is the vortex-lattice method. This method can fully account for the aerodynamic interactions among several lifting surfaces having arbitrary platforms, camber, and twist as long as separation occurs only along the edges and the phenomenon known as vortex bursting does not occur near the sails. This paper describes this method and how it can be applied to the design of sails.

  2. CATIA - A computer aided design and manufacturing tridimensional system

    Science.gov (United States)

    Bernard, F.

    A properietary computer graphics-aided, three-dimensional interactive application (CATIA) design system is described. CATIA employs approximately 100 graphics displays, which are used by some 500 persons engaged in the definition of aircraft structures, structural strength analyses, the kinematic analysis of mobile elements, aerodynamic calculations, the choice of tooling in the machining of aircraft elements, and the programming of robotics. CATIA covers these diverse fields with a single data base. After a description of salient aspects of the system's hardware and software, graphics examples are given of the definition of curves, surfaces, complex volumes, and analytical tasks.

  3. Computer-Aided Design of RNA Origami Structures.

    Science.gov (United States)

    Sparvath, Steffen L; Geary, Cody W; Andersen, Ebbe S

    2017-01-01

    RNA nanostructures can be used as scaffolds to organize, combine, and control molecular functionalities, with great potential for applications in nanomedicine and synthetic biology. The single-stranded RNA origami method allows RNA nanostructures to be folded as they are transcribed by the RNA polymerase. RNA origami structures provide a stable framework that can be decorated with functional RNA elements such as riboswitches, ribozymes, interaction sites, and aptamers for binding small molecules or protein targets. The rich library of RNA structural and functional elements combined with the possibility to attach proteins through aptamer-based binding creates virtually limitless possibilities for constructing advanced RNA-based nanodevices.In this chapter we provide a detailed protocol for the single-stranded RNA origami design method using a simple 2-helix tall structure as an example. The first step involves 3D modeling of a double-crossover between two RNA double helices, followed by decoration with tertiary motifs. The second step deals with the construction of a 2D blueprint describing the secondary structure and sequence constraints that serves as the input for computer programs. In the third step, computer programs are used to design RNA sequences that are compatible with the structure, and the resulting outputs are evaluated and converted into DNA sequences to order.

  4. Computer-Aided Drug Design of Bioactive Natural Products.

    Science.gov (United States)

    Prachayasittikul, Veda; Worachartcheewan, Apilak; Shoombuatong, Watshara; Songtawee, Napat; Simeon, Saw; Prachayasittikul, Virapong; Nantasenamat, Chanin

    2015-01-01

    Natural products have been an integral part of sustaining civilizations because of their medicinal properties. Past discoveries of bioactive natural products have relied on serendipity, and these compounds serve as inspiration for the generation of analogs with desired physicochemical properties. Bioactive natural products with therapeutic potential are abundantly available in nature and some of them are beyond exploration by conventional methods. The effectiveness of computational approaches as versatile tools for facilitating drug discovery and development has been recognized for decades, without exception, in the case of natural products. In the post-genomic era, scientists are bombarded with data produced by advanced technologies. Thus, rendering these data into knowledge that is interpretable and meaningful becomes an essential issue. In this regard, computational approaches utilize the existing data to generate knowledge that provides valuable understanding for addressing current problems and guiding the further research and development of new natural-derived drugs. Furthermore, several medicinal plants have been continuously used in many traditional medicine systems since antiquity throughout the world, and their mechanisms have not yet been elucidated. Therefore, the utilization of computational approaches and advanced synthetic techniques would yield great benefit to improving the world's health population and well-being.

  5. Usability Studies in Virtual and Traditional Computer Aided Design Environments for Fault Identification

    Science.gov (United States)

    2017-08-08

    IDENTIFICATION) 1. Description In a typical design review process, a design space is presented to the reviewer(s) who examine the space for design ...Usability Studies In Virtual And Traditional Computer Aided Design Environments For Fault Identification Dr. Syed Adeel Ahmed, Xavier University...sacrificing accuracy. The research team timed each task, and recorded activity on evaluation sheets for Fault Identification Test. At the

  6. A survey and evaluation of microbased computer aided design systems for design education and practice in Scotland primarily in the area of product design: their application, problems and potential solutions

    OpenAIRE

    Carter, Roderick P.

    1992-01-01

    The initial premise of the research centred around the relatively new adoption by the Product Design sector of Computer Aided Design technology. Problems Were expected to occur in applying the hardware and understanding the terminology of the software by this sector which prides itself In its artisan skills. The aim of the work was to determine the extent of the adoption of Computer Aided Design and to clarify the problem areas. The research determined, by study of more experienced but sim...

  7. Computer-Aided Design Method of Warp-Knitted Jacquard Spacer Fabrics

    Directory of Open Access Journals (Sweden)

    Li Xinxin

    2016-06-01

    Full Text Available Based on a further study on knitting and jacquard principles, this paper presents a mathematical design model to make computer-aided design of warp-knitted jacquard spacer fabrics more efficient. The mathematical model with matrix method employs three essential elements of chain notation, threading and Jacquard designing. With this model, the processing to design warp-knitted jacquard spacer fabrics with CAD software is also introduced. In this study, the sports shoes which have separated functional areas according to the feet structure and characteristics of movement are analysed. The results show the different patterns on Jacquard spacer fabrics that are seamlessly stitched with jacquard technics. The computer-aided design method of warp-knitted jacquard spacer fabrics is efficient and simple.

  8. Chapter 6 – Computer-Aided Molecular Design and Property Prediction

    DEFF Research Database (Denmark)

    Gani, Rafiqul; Zhang, L.; Kalakul, Sawitree

    2017-01-01

    Today's society needs many chemical-based products for its survival, nutrition, health, transportation, agriculture, and the functioning of processes. Chemical-based products have to be designed/developed in order to meet these needs, while at the same time, they must be innovative and sustainable...... to meet the global challenges of resources, competition, and demand. Design/development of these products mostly follows experiment-based trial and error approaches. With the availability of reliable property prediction models, however, computer-aided techniques have become popular, at least...... for the initial stages of the design/development process. Therefore, computer-aided molecular design and property prediction techniques are two topics that play important roles in chemical product design, analysis, and application. In this chapter, an overview of the concepts, methods, and tools related...

  9. A computer-aided molecular design framework for crystallization solvent design

    DEFF Research Database (Denmark)

    Karunanithi, Arunprakash T.; Achenie, Luke E.K.; Gani, Rafiqul

    2006-01-01

    One of the key decisions in designing solution crystallization processes is the selection of solvents. In this paper, we present a computer-aided molecular design (CAMD) framework for the design and selection of solvents and/or anti-solvents for solution crystallization. The CAMD problem......, property requirements such as solubility, crystal morphology, flashpoint, toxicity, viscosity, normal boiling and melting point are posed as constraints. All the properties are estimated using group contribution methods. The MINLP model is then solved using a decomposition approach to obtain optimal...... solvent molecules. Solvent design and selection for two types of solution crystallization processes namely cooling crystallization and drowning out crystallization are presented. In the first case study, the design of single compound solvent for crystallization of ibuprofen, which is an important...

  10. A QFD-based decision making model for computer-aided design software selection

    Directory of Open Access Journals (Sweden)

    Kanika Prasad

    2016-03-01

    Full Text Available With the progress in technology and innovation in product development, the contribution of computer- aided design (CAD software in the design and manufacture of parts/products is growing on significantly. Selection of an appropriate CAD software is not a trifling task as it involves analyzing the appositeness of the available software packages to the unique requirements of the organization. Existence of a large number of CAD software vendors, presence of discordance among different hardware and software systems, and dearth of technical knowledge and experience of the decision makers further complicate the selection procedure. Moreover, there are very few published research papers related to CAD software selection, and majority of them have either employed criteria weights computed utilizing subjective judgements of the end users or floundered to incorporate the voice of customers in the decision making process. Quality function deployment (QFD is a well-known technique for determining the relative importance of customers’ defined criteria for selection of any product or service. Therefore, this paper deals with design and development of a QFD-based decision making model in Visual BASIC 6.0 for selection of CAD software for manufacturing organizations. In order to demonstrate the applicability and potentiality of the developed model in the form of a software prototype, two illustrative examples are also provided.

  11. Computer-aided Nonlinear Control System Design Using Describing Function Models

    CERN Document Server

    Nassirharand, Amir

    2012-01-01

    A systematic computer-aided approach provides a versatile setting for the control engineer to overcome the complications of controller design for highly nonlinear systems. Computer-aided Nonlinear Control System Design provides such an approach based on the use of describing functions. The text deals with a large class of nonlinear systems without restrictions on the system order, the number of inputs and/or outputs or the number, type or arrangement of nonlinear terms. The strongly software-oriented methods detailed facilitate fulfillment of tight performance requirements and help the designer to think in purely nonlinear terms, avoiding the expedient of linearization which can impose substantial and unrealistic model limitations and drive up the cost of the final product. Design procedures are presented in a step-by-step algorithmic format each step being a functional unit with outputs that drive the other steps. This procedure may be easily implemented on a digital computer with example problems from mecha...

  12. Modeling uncertainty in classification design of a computer-aided detection system

    Science.gov (United States)

    Hosseini, Rahil; Dehmeshki, Jamshid; Barman, Sarah; Mazinani, Mahdi; Qanadli, Salah

    2010-03-01

    A computerized image analysis technology suffers from imperfection, imprecision and vagueness of the input data and its propagation in all individual components of the technology including image enhancement, segmentation and pattern recognition. Furthermore, a Computerized Medical Image Analysis System (CMIAS) such as computer aided detection (CAD) technology deals with another source of uncertainty that is inherent in image-based practice of medicine. While there are several technology-oriented studies reported in developing CAD applications, no attempt has been made to address, model and integrate these types of uncertainty in the design of the system components, even though uncertainty issues directly affect the performance and its accuracy. In this paper, the main uncertainty paradigms associated with CAD technologies are addressed. The influence of the vagueness and imprecision in the classification of the CAD, as a second reader, on the validity of ROC analysis results is defined. In order to tackle the problem of uncertainty in the classification design of the CAD, two fuzzy methods are applied and evaluated for a lung nodule CAD application. Type-1 fuzzy logic system (T1FLS) and an extension of it, interval type-2 fuzzy logic system (IT2FLS) are employed as methods with high potential for managing uncertainty issues. The novelty of the proposed classification methods is to address and handle all sources of uncertainty associated with a CAD system. The results reveal that IT2FLS is superior to T1FLS for tackling all sources of uncertainty and significantly, the problem of inter and intra operator observer variability.

  13. Computer Aided Design and Analysis of Separation Processes with Electrolyte Systems

    DEFF Research Database (Denmark)

    Takano, Kiyoteru; Gani, Rafiqul; Kolar, P.

    2000-01-01

    A methodology for computer aided design and analysis of separation processes involving electrolyte systems is presented. The methodology consists of three main parts. The thermodynamic part 'creates' the problem specific property model package, which is a collection of pure component and mixture...... property models. The design and analysis part generates process (flowsheet) alternatives, evaluates/analyses feasibility of separation and provides a visual operation path for the desired separation. The simulation part consists of a simulation/calculation engine that allows the screening and validation...... of process alternatives. For the simulation part, a general multi-purpose, multi-phase separation model has been developed and integrated to an existing computer aided system. Application of the design and analysis methodology is highlighted through two illustrative case studies, (C) 2000 Elsevier Science...

  14. Computer Aided Design and Analysis of Separation Processes with Electrolyte Systems

    DEFF Research Database (Denmark)

    A methodology for computer aided design and analysis of separation processes involving electrolyte systems is presented. The methodology consists of three main parts. The thermodynamic part "creates" the problem specific property model package, which is a collection of pure component and mixture...... property models. The design and analysis part generates process (flowsheet) alternatives, evaluates/analyses feasibility of separation and provides a visual operation path for the desired separation. The simulation part consists of a simulation/calculation engine that allows the screening and validation...... of process alternatives. For the simulation part, a general multi-purpose, multi-phase separation model has been developed and integrated to an existing computer aided system. Application of the design and analysis methodology is highlighted through two illustrative case studies....

  15. Computer Aided Design and Analysis of Separation Processes with Electrolyte Systems

    DEFF Research Database (Denmark)

    A methodology for computer aided design and analysis of separation processes involving electrolyte systems is presented. The methodology consists of three main parts. The thermodynamic part "creates" the problem specific property model package, which is a collection of pure component and mixture...... property models. The design and analysis part generates process (flowsheet) alternatives, evaluates/analyses feasibility of separation and provides a visual operation path for the desired separation. The simulation part consists of a simulation/calculation engine that allows the screening and validation...... of process alternatives. For the simulation part, a general multi-purpose, multi-phase separation model has been developed and integrated to an existing computer aided system. Application of the design and analysis methodology is highlighted through two illustrative case studies....

  16. Computer-aided analysis and design of the shape rolling process for producing turbine engine airfoils

    Science.gov (United States)

    Lahoti, G. D.; Akgerman, N.; Altan, T.

    1978-01-01

    Mild steel (AISI 1018) was selected as model cold rolling material and Ti-6A1-4V and Inconel 718 were selected as typical hot rolling and cold rolling alloys, respectively. The flow stress and workability of these alloys were characterized and friction factor at the roll/workpiece interface was determined at their respective working conditions by conducting ring tests. Computer-aided mathematical models for predicting metal flow and stresses, and for simulating the shape rolling process were developed. These models utilized the upper bound and the slab methods of analysis, and were capable of predicting the lateral spread, roll separating force, roll torque, and local stresses, strains and strain rates. This computer-aided design system was also capable of simulating the actual rolling process, and thereby designing the roll pass schedule in rolling of an airfoil or a similar shape.

  17. Usability Studies In Virtual And Traditional Computer Aided Design Environments For Spatial Awareness

    Science.gov (United States)

    2017-08-08

    Usability Studies In Virtual And Traditional Computer Aided Design Environments For Spatial Awareness Dr. Syed Adeel Ahmed, Xavier University of...sacrificing accuracy. The research team timed each task, and recorded activity on evaluation sheets for spatial awareness Test. At the completion of the...The significance and the detail description of this study is very well explained by Satter (2012) in his recent paper. Here we only present the

  18. Generic Mathematical Programming Formulation and Solution for Computer-Aided Molecular Design

    OpenAIRE

    2015-01-01

    This short communication presents a generic mathematical programming formulation for Computer-Aided Molecular Design (CAMD). A given CAMD problem, based on target properties, is formulated as a Mixed Integer Linear/Non-Linear Program (MILP/MINLP). The mathematical programming model presented here, which is formulated as an MILP/MINLP problem, considers first-order and second-order molecular groups for molecular structure representation and property estimation. It is shown that various CAMD pr...

  19. Design and Implementation of 3 Axis CNC Router for Computer Aided Manufacturing Courses

    OpenAIRE

    Aktan Mehmet Emin; Akkuş Nihat; Yılmaz Abdurrahman; Akdoğan Erhan

    2016-01-01

    In this paper, it is intended to make the mechanical design of 3 axis Computer Numerical Control (CNC) router with linear joints, production of electronic control interface cards and drivers and manufacturing of CNC router system which is a combination of mechanics and electronics. At the same time, interface program has been prepared to control router via USB. The router was developed for educational purpose. In some vocational schools and universities, Computer Aided Manufacturing (CAM) cou...

  20. Integrating aerodynamic surface modeling for computational fluid dynamics with computer aided structural analysis, design, and manufacturing

    Science.gov (United States)

    Thorp, Scott A.

    1992-01-01

    This presentation will discuss the development of a NASA Geometry Exchange Specification for transferring aerodynamic surface geometry between LeRC systems and grid generation software used for computational fluid dynamics research. The proposed specification is based on a subset of the Initial Graphics Exchange Specification (IGES). The presentation will include discussion of how the NASA-IGES standard will accommodate improved computer aided design inspection methods and reverse engineering techniques currently being developed. The presentation is in viewgraph format.

  1. Basic Principles of Industrial Electric Power Network Computer Aided Design and Engineering

    OpenAIRE

    M. Fursanov; I. Dul

    2012-01-01

    A conceptual model for a computer aided design and engineering system has been developed in the paper. The paper presents basic automation process principles including a graphical representation   network and calculation results, convenient user interface, automatic mode calculation, selection of transformer rated power and cross-section area of wires. The developed algorithm and program make it possible to save time and improve quality of project implementation.

  2. On the Variety of Planar Spirals and Their Applications in Computer Aided Design

    Directory of Open Access Journals (Sweden)

    Kenjiro T. Miura

    2012-08-01

    Full Text Available In this paper we discuss the variety of planar spiral segments and their applications in objects in both the real and artificial world. The discussed curves with monotonic curvature function are well-known in geometric modelling and computer aided geometric design as fair curves, and they are very significant in aesthetic shape modelling. Fair curve segments are used for two-point G1 and G2 Hermite interpolation, as well as for generating aesthetic splines.

  3. Basic Principles of Industrial Electric Power Network Computer Aided Design and Engineering

    Directory of Open Access Journals (Sweden)

    M. Fursanov

    2012-01-01

    Full Text Available A conceptual model for a computer aided design and engineering system has been developed in the paper. The paper presents basic automation process principles including a graphical representation   network and calculation results, convenient user interface, automatic mode calculation, selection of transformer rated power and cross-section area of wires. The developed algorithm and program make it possible to save time and improve quality of project implementation.

  4. Development of simulation tools for numerical investigation and computer-aided design (CAD) of gyrotrons

    Science.gov (United States)

    Damyanova, M.; Sabchevski, S.; Zhelyazkov, I.; Vasileva, E.; Balabanova, E.; Dankov, P.; Malinov, P.

    2016-10-01

    As the most powerful CW sources of coherent radiation in the sub-terahertz to terahertz frequency range the gyrotrons have demonstrated a remarkable potential for numerous novel and prospective applications in the fundamental physical research and the technologies. Among them are powerful gyrotrons for electron cyclotron resonance heating (ECRH) and current drive (ECCD) of magnetically confined plasma in various reactors for controlled thermonuclear fusion (e.g., tokamaks and most notably ITER), high-frequency gyrotrons for sub-terahertz spectroscopy (for example NMR-DNP, XDMR, study of the hyperfine structure of positronium, etc.), gyrotrons for thermal processing and so on. Modelling and simulation are indispensable tools for numerical studies, computer-aided design (CAD) and optimization of such sophisticated vacuum tubes (fast-wave devices) operating on a physical principle known as electron cyclotron resonance maser (ECRM) instability. During the recent years, our research team has been involved in the development of physical models and problem-oriented software packages for numerical analysis and CAD of different gyrotrons in the framework of a broad international collaboration. In this paper we present the current status of our simulation tools (GYROSIM and GYREOSS packages) and illustrate their functionality by results of numerical experiments carried out recently. Finally, we provide an outlook on the envisaged further development of the computer codes and the computational modules belonging to these packages and specialized to different subsystems of the gyrotrons.

  5. Integrated computer-aided design in automotive development development processes, geometric fundamentals, methods of CAD, knowledge-based engineering data management

    CERN Document Server

    Mario, Hirz; Gfrerrer, Anton; Lang, Johann

    2013-01-01

    The automotive industry faces constant pressure to reduce development costs and time while still increasing vehicle quality. To meet this challenge, engineers and researchers in both science and industry are developing effective strategies and flexible tools by enhancing and further integrating powerful, computer-aided design technology. This book provides a valuable overview of the development tools and methods of today and tomorrow. It is targeted not only towards professional project and design engineers, but also to students and to anyone who is interested in state-of-the-art computer-aided development. The book begins with an overview of automotive development processes and the principles of virtual product development. Focusing on computer-aided design, a comprehensive outline of the fundamentals of geometry representation provides a deeper insight into the mathematical techniques used to describe and model geometrical elements. The book then explores the link between the demands of integrated design pr...

  6. Research on Computer Aided Design (CAD) Technique and Novel Pattern for Electronic Architectural Drawing and Perspective

    Institute of Scientific and Technical Information of China (English)

    Tian XiJiang

    2015-01-01

    With the progress of computer technology, CAD technique is urgent needed. In this paper, we conduct numerical and theoretical analysis and research on computer aided design technique and novel pattern for electronic architectural drawing and perspective. AUTOCAD drawing soRware because of its versatility and easy entry, in engineering has broad user base, but also because of the basis of general drawing software, often cannot directly use of the existing order efficiently complete professional drawing. We modify the current pattern and introduce our proposed pattern for advancement. The experiment proves the effectiveness of the pattern. In addition, we will conduct more insightful research in the future to nolish the current anoroach.

  7. Planning tools for environmental-orientated technology management - computer aided lifecycle analysis; Planungshilfsmittel fuer das oekologieorientierte Technologiemanagement - Computer Aided Lifecycle Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Boehlke, U.H. [Fraunhofer-Institut fuer Produktionstechnologie, Aachen (Germany); Eversheim, W.; Albrecht, T.

    1995-12-31

    The high pressure on prices in the automotive industry as well as the aim to improve the ecological tolerance of the individual motor car traffic requires a considerate employment of natural ressources. In this connection the selection of material is of special improtance. Due to the systematic recording and evaluation of appropriate requirements of ressources, decissions concerning the selection of material and technology can be supported with a product-related and comprehensive balance in kind. The EDV-prototype CALA (Computer Aided Lifecycle Analysis) was developed in order to reduce the effort of a balance in kind to a minimum. CALA supports the user in capturing data and data processing through a dialogue-oriented display mask and through providing of relevant ecological master data. (orig.) [Deutsch] Sowohl der hohe Kostendruck in der Automobilbranche als auch das Ziel die oekologische Vertraeglichkeit des Individualverkehrs zu verbessern, erfordern einen schonenden Einsatz der natuerlichen Ressourcen. Eine besondere Bedeutung kommt dabei der Werkstoffauswahl zu. Mit einer produktbezogenen, ganzheitlichen Sachbilanzierung koennen, durch die systematische Erfassung und Bewertung entsprechender Ressourcenbedarfe und Umweltbelastungen, Entscheidungen bei der Werkstoff- oder Technologieauswahl unterstuetzt werden. Um den Aufwand bei der Durchfuehrung einer Sachbilanzierung zu minimieren, wurde der EDV-Prototyp CALA (Computer Aided Lifecycle Analysis) entwickelt. Der Anwender wird bei CALA durch dialogorientierte Bildschirmmasken und die Bereitstellung oekologisch relevanter Stammdaten bei der Datenerfassung und Auswertung effektiv unterstuetzt. (orig.)

  8. Computer Aided Design and Analysis of a 2-4 GHz Broadband Balanced Microstrip Amplifier

    OpenAIRE

    S. H. Ibrahim

    2012-01-01

    In this paper, a computer-aided design and analysis of a 2-4 GHz broadband balanced microstrip amplifier using a full computer simulation program developed by the author and others is presented. A short and efficient CAD procedure for broadband amplifier design is introduced. The first step is to design an initial narrow-band high gain microstrip amplifier at 3-GHz central frequency. The second step is to optimize the initial lengths and widths of the input and output microstrip-matching circ...

  9. [Semi-adjustable articulator for computer aided design of complete denture].

    Science.gov (United States)

    Sun, Yu-Chun; L V, Pei-Jun; Wang, Yong

    2008-02-18

    To explore virtual semi-adjustable articulator for complete denture computer aided design (CAD) system, and to simulate biting motion and virtual occlusal adjustment for a complete denture CAD digital model. The edentulous jaw casts, rims and bite records of forward protrusion were made in clinic. The casts were fixed to the articulator and inclination of protrusive condylar guidance was set up with bite records of forward protrusion. Inclination of lateral condylar guidance was calculated and set up with Hanus formula. Inclination of protrusive incisal guidance inclination was calculated and set up with ratios of over bite and overjet of complete denture CAD digital model which have been designed with Complete Denture CAD System. The 3D locus data of semi-adjustable articulator was obtained by scanning three points on articulator with contact head of FARO ScanArm (FARO Technologies Inc., American). In the same scanning coordinate system, the laser scanner was used to get labial/buccal surface data of rims at centric relation position. Based on rims, the coordinate system was set up and the complete denture CAD model was aligned to the locus data. The virtual articulator program was explored with Scoll language offered by Imageware (EDS corp., American). The 3D biting motion simulating, automatic occluding relation detection and automatic occlusal adjustment functions were supported by the program. A virtual semi-adjustable articulator program for Complete Denture CAD System was explored and applied to a complete denture CAD digital model. With the program, 3D biting motion simulating, automatic occluding relation detection and automatic occlusal adjustment can be realized. A technical route of virtual articulator is set up based on semi-adjustable articulator and initial approach is carried out for application of the virtual articulator in CAD progress of complete denture.

  10. The future of computer-aided design and engineering at CERN

    CERN Document Server

    Høimyr, Nils-Joar

    2004-01-01

    This working note discusses design and engineering processes at CERN and Computer Aided Design and Engineering tools. The main focus of this note is Mechanical design and CAE activities and how to share and organize the data produced by CAD/CAE tools. These issues cannot be addressed without taking a global view of the engineering activities at CERN. As more and more of the detailed design work is done by external suppliers, the design processes at CERN change. Traditional design work where draftsmen are producing drawings on the request from engineers is replaced by conceptual design work done by domain specialists and engineers. Furthermore CAD and FEM tools have evolved from specialist tools to mainstream utilities mastered by most engineers. Design activities nowadays can now be carried out directly by the project engineer without the use of a design (drawing) office. This environment poses different requirements for design- and engineering support activities as well as the selection of CAE-tools. Design ...

  11. Custom-Made Computer-Aided-Design/Computer-Aided-Manufacturing Biphasic Calcium-Phosphate Scaffold for Augmentation of an Atrophic Mandibular Anterior Ridge

    Directory of Open Access Journals (Sweden)

    Francesco Guido Mangano

    2015-01-01

    Full Text Available This report documents the clinical, radiographic, and histologic outcome of a custom-made computer-aided-design/computer-aided-manufactured (CAD/CAM scaffold used for the alveolar ridge augmentation of a severely atrophic anterior mandible. Computed tomographic (CT images of an atrophic anterior mandible were acquired and modified into a 3-dimensional (3D reconstruction model; this was transferred to a CAD program, where a custom-made scaffold was designed. CAM software generated a set of tool-paths for the manufacture of the scaffold on a computer-numerical-control milling machine into the exact shape of the 3D design. A custom-made scaffold was milled from a synthetic micromacroporous biphasic calcium phosphate (BCP block. The scaffold closely matched the shape of the defect: this helped to reduce the time for the surgery and contributed to good healing. One year later, newly formed and well-integrated bone was clinically available, and two implants (AnyRidge, MegaGen, Gyeongbuk, South Korea were placed. The histologic samples retrieved from the implant sites revealed compact mature bone undergoing remodelling, marrow spaces, and newly formed trabecular bone surrounded by residual BCP particles. This study demonstrates that custom-made scaffolds can be fabricated by combining CT scans and CAD/CAM techniques. Further studies on a larger sample of patients are needed to confirm these results.

  12. Evaluation of marginal/internal fit of chrome-cobalt crowns: Direct laser metal sintering versus computer-aided design and computer-aided manufacturing.

    Science.gov (United States)

    Gunsoy, S; Ulusoy, M

    2016-01-01

    The purpose of this study was to evaluate the internal and marginal fit of chrome cobalt (Co-Cr) crowns were fabricated with laser sintering, computer-aided design (CAD) and computer-aided manufacturing, and conventional methods. Polyamide master and working models were designed and fabricated. The models were initially designed with a software application for three-dimensional (3D) CAD (Maya, Autodesk Inc.). All models were fabricated models were produced by a 3D printer (EOSINT P380 SLS, EOS). 128 1-unit Co-Cr fixed dental prostheses were fabricated with four different techniques: Conventional lost wax method, milled wax with lost-wax method (MWLW), direct laser metal sintering (DLMS), and milled Co-Cr (MCo-Cr). The cement film thickness of the marginal and internal gaps was measured by an observer using a stereomicroscope after taking digital photos in ×24. Best fit rates according to mean and standard deviations of all measurements was in DLMS both in premolar (65.84) and molar (58.38) models in μm. A significant difference was found DLMS and the rest of fabrication techniques (P 0.05). DMLS was best fitting fabrication techniques for single crown based on the results.The best fit was found in marginal; the larger gap was found in occlusal.All groups were within the clinically acceptable misfit range.

  13. Computer-aided design studies of the homopolar linear synchronous motor

    Science.gov (United States)

    Dawson, G. E.; Eastham, A. R.; Ong, R.

    1984-09-01

    The linear induction motor (LIM), as an urban transit drive, can provide good grade-climbing capabilities and propulsion/braking performance that is independent of steel wheel-rail adhesion. In view of its 10-12 mm airgap, the LIM is characterized by a low power factor-efficiency product of order 0.4. A synchronous machine offers high efficiency and controllable power factor. An assessment of the linear homopolar configuration of this machine is presented as an alternative to the LIM. Computer-aided design studies using the finite element technique have been conducted to identify a suitable machine design for urban transit propulsion.

  14. Metalloporphyrin catalysts for oxygen reduction developed using computer-aided molecular design

    Energy Technology Data Exchange (ETDEWEB)

    Ryba, G.N.; Hobbs, J.D.; Shelnutt, J.A. [and others

    1996-04-01

    The objective of this project is the development of a new class of metalloporphyrin materials used as catalsyts for use in fuel cell applications. The metalloporphyrins are excellent candidates for use as catalysts at both the anode and cathode. The catalysts reduce oxygen in 1 M potassium hydroxide, as well as in 2 M sulfuric acid. Covalent attachment to carbon supports is being investigated. The computer-aided molecular design is an iterative process, in which experimental results feed back into the design of future catalysts.

  15. Tailor-made Design of Chemical Blends using Decomposition-based Computer-aided Approach

    DEFF Research Database (Denmark)

    Yunus, Nor Alafiza; Manan, Zainuddin Abd.; Gernaey, Krist

    methodology for blended liquid products that identifies a set of feasible chemical blends. The blend design problem is formulated as a nonlinear programming (NLP) model where the objective is to find the optimal blended gasoline or diesel product subject to blend chemicals and their compositions, a set...... to a specified priority. Finally, a short list of candidates, ordered in terms of specified performance criteria, is produced for final testing and selection. This systematic and computer-aided approach is illustrated through a case study involving the design of blends of gasoline with oxygenates from biomass...

  16. Design of tailor-made chemical blend using a decomposition-based computer-aided approach

    DEFF Research Database (Denmark)

    Yunus, Nor Alafiza; Gernaey, Krist; Manan, Z.A.

    2011-01-01

    methodology for blended liquid products that identifies a set of feasible chemical blends. The blend design problem is formulated as a Mixed Integer Nonlinear Programming (MINLP) model where the objective is to find the optimal blended gasoline or diesel product subject to types of chemicals....... The application of this systematic and computer-aided approach is illustrated through a case study involving the design of blends of gasoline with oxygenated compounds resulting from degradation and fermentation of biomass for use in internal combustion engines. Emphasis is given here on the concepts used...

  17. Computer Aided Design and Analysis of a 2-4 GHz Broadband Balanced Microstrip Amplifier

    Directory of Open Access Journals (Sweden)

    S. H. Ibrahim

    2012-07-01

    Full Text Available In this paper, a computer-aided design and analysis of a 2-4 GHz broadband balanced microstrip amplifier using a full computer simulation program developed by the author and others is presented. A short and efficient CAD procedure for broadband amplifier design is introduced. The first step is to design an initial narrow-band high gain microstrip amplifier at 3-GHz central frequency. The second step is to optimize the initial lengths and widths of the input and output microstrip-matching circuits to get the broadband amplifier over the range 2-4 GHz. The analysis of both narrow and broadband amplifiers is investigated. In addition, with the design and analysis of a low-pass microstrip filter, the paper introduces the design and analysis of a Lange coupler. The final AC schematic diagram of the designed amplifier with the lengths and widths of microstrip lines is presented.Key Words: Computer-Aided Design and Analysis, Microstrip Amplifier, Microwave Amplifier.

  18. Computer-aided design of the RF-cavity for a high-power S-band klystron

    Science.gov (United States)

    Kant, D.; Bandyopadhyay, A. K.; Pal, D.; Meena, R.; Nangru, S. C.; Joshi, L. M.

    2012-08-01

    This article describes the computer-aided design of the RF-cavity for a S-band klystron operating at 2856 MHz. State-of-the-art electromagnetic simulation tools SUPERFISH, CST Microwave studio, HFSS and MAGIC have been used for cavity design. After finalising the geometrical details of the cavity through simulation, it has been fabricated and characterised through cold testing. Detailed results of the computer-aided simulation and cold measurements are presented in this article.

  19. Analytical Design Package (ADP2): A computer aided engineering tool for aircraft transparency design

    Science.gov (United States)

    Wuerer, J. E.; Gran, M.; Held, T. W.

    1994-01-01

    The Analytical Design Package (ADP2) is being developed as a part of the Air Force Frameless Transparency Program (FTP). ADP2 is an integrated design tool consisting of existing analysis codes and Computer Aided Engineering (CAE) software. The objective of the ADP2 is to develop and confirm an integrated design methodology for frameless transparencies, related aircraft interfaces, and their corresponding tooling. The application of this methodology will generate high confidence for achieving a qualified part prior to mold fabrication. ADP2 is a customized integration of analysis codes, CAE software, and material databases. The primary CAE integration tool for the ADP2 is P3/PATRAN, a commercial-off-the-shelf (COTS) software tool. The open architecture of P3/PATRAN allows customized installations with different applications modules for specific site requirements. Integration of material databases allows the engineer to select a material, and those material properties are automatically called into the relevant analysis code. The ADP2 materials database will be composed of four independent schemas: CAE Design, Processing, Testing, and Logistics Support. The design of ADP2 places major emphasis on the seamless integration of CAE and analysis modules with a single intuitive graphical interface. This tool is being designed to serve and be used by an entire project team, i.e., analysts, designers, materials experts, and managers. The final version of the software will be delivered to the Air Force in Jan. 1994. The Analytical Design Package (ADP2) will then be ready for transfer to industry. The package will be capable of a wide range of design and manufacturing applications.

  20. Report on DOE - industry workshop on Computer-Aided Catalyst Design (CACD)

    Energy Technology Data Exchange (ETDEWEB)

    Hay, P.J. [comp.

    1994-07-01

    Representatives from industry, national laboratories, and the DOE met to review the status of the DOE-sponsored Computer-Aided Catalyst Design (CACD) program and to assess current industrial needs in CACD. Of the 40 participants at the workshop, nearly half were from industry representing 12 companies--Arco Chemical, Amoco Chemical, Biosym, Dow, DuPont, Exxon, Ford, General Motors, Mobil, Monsanto, W.R. Grace and Union Carbide--that included nine of the largest chemical producers in the U.S. representing $61 billion in chemical sales in 1993. An overview of developments in catalyst modeling at the national laboratories was presented, and current CACD-related activities at each of the companies were described by the industrial participants. The CACD program is addressing important industry needs and is having a significant impact despite the current limited scope and budget. The industrial participants urged the program to continue to target specific areas and to encourage collaborative work among the national labs. Industrial participants expressed strong interest in increased interactions with CACD activities at the national labs, where competencies in theory, modeling, and simulation complement the traditional strengths of catalysis expertise in industry. The chemical, refining and automotive industries face continual economic and environmental pressures for now or improved catalytic processes that are more efficient and produce fewer undesirable byproducts. CACD is viewed as an effective means to enhance experimental catalysis research. The industrial participants attested to the importance of developing and applying catalysis modeling capabilities. The companies represented at the meeting had varying degrees of activity in this area, and many already had significant interactions with national labs. As potential users of this technology, they strongly endorsed the work in the CACD program in the development of modeling capabilities.

  1. New layer-based imaging and rapid prototyping techniques for computer-aided design and manufacture of custom dental restoration.

    Science.gov (United States)

    Lee, M-Y; Chang, C-C; Ku, Y C

    2008-01-01

    Fixed dental restoration by conventional methods greatly relies on the skill and experience of the dental technician. The quality and accuracy of the final product depends mostly on the technician's subjective judgment. In addition, the traditional manual operation involves many complex procedures, and is a time-consuming and labour-intensive job. Most importantly, no quantitative design and manufacturing information is preserved for future retrieval. In this paper, a new device for scanning the dental profile and reconstructing 3D digital information of a dental model based on a layer-based imaging technique, called abrasive computer tomography (ACT) was designed in-house and proposed for the design of custom dental restoration. The fixed partial dental restoration was then produced by rapid prototyping (RP) and computer numerical control (CNC) machining methods based on the ACT scanned digital information. A force feedback sculptor (FreeForm system, Sensible Technologies, Inc., Cambridge MA, USA), which comprises 3D Touch technology, was applied to modify the morphology and design of the fixed dental restoration. In addition, a comparison of conventional manual operation and digital manufacture using both RP and CNC machining technologies for fixed dental restoration production is presented. Finally, a digital custom fixed restoration manufacturing protocol integrating proposed layer-based dental profile scanning, computer-aided design, 3D force feedback feature modification and advanced fixed restoration manufacturing techniques is illustrated. The proposed method provides solid evidence that computer-aided design and manufacturing technologies may become a new avenue for custom-made fixed restoration design, analysis, and production in the 21st century.

  2. Design and fabrication of facial prostheses for cancer patient applying computer aided method and manufacturing (CADCAM)

    Science.gov (United States)

    Din, Tengku Noor Daimah Tengku; Jamayet, Nafij; Rajion, Zainul Ahmad; Luddin, Norhayati; Abdullah, Johari Yap; Abdullah, Abdul Manaf; Yahya, Suzana

    2016-12-01

    Facial defects are either congenital or caused by trauma or cancer where most of them affect the person appearance. The emotional pressure and low self-esteem are problems commonly related to patient with facial defect. To overcome this problem, silicone prosthesis was designed to cover the defect part. This study describes the techniques in designing and fabrication for facial prosthesis applying computer aided method and manufacturing (CADCAM). The steps of fabricating the facial prosthesis were based on a patient case. The patient was diagnosed for Gorlin Gotz syndrome and came to Hospital Universiti Sains Malaysia (HUSM) for prosthesis. The 3D image of the patient was reconstructed from CT data using MIMICS software. Based on the 3D image, the intercanthal and zygomatic measurements of the patient were compared with available data in the database to find the suitable nose shape. The normal nose shape for the patient was retrieved from the nasal digital library. Mirror imaging technique was used to mirror the facial part. The final design of facial prosthesis including eye, nose and cheek was superimposed to see the result virtually. After the final design was confirmed, the mould design was created. The mould of nasal prosthesis was printed using Objet 3D printer. Silicone casting was done using the 3D print mould. The final prosthesis produced from the computer aided method was acceptable to be used for facial rehabilitation to provide better quality of life.

  3. Effects of Computer-Aided Manufacturing Technology on Precision of Clinical Metal-Free Restorations

    Directory of Open Access Journals (Sweden)

    Ki-Hong Lee

    2015-01-01

    Full Text Available Purpose. The purpose of this study was to investigate the marginal fit of metal-free crowns made by three different computer-aided design/computer-aided manufacturing (CAD/CAM systems. Materials and Methods. The maxillary left first premolar of a dentiform was prepared for all-ceramic crown restoration. Thirty all-ceramic premolar crowns were made, ten each manufactured by the Lava system, Cercon, and Cerec. Ten metal ceramic gold (MCG crowns served as control. The marginal gap of each sample was measured under a stereoscopic microscope at 75x magnification after cementation. One-way ANOVA and the Duncan’s post hoc test were used for data analysis at the significance level of 0.05. Results. The mean (standard deviation marginal gaps were 70.5 (34.4 μm for the MCG crowns, 87.2 (22.8 μm for Lava, 58.5 (17.6 μm for Cercon, and 72.3 (30.8 μm for Cerec. There were no significant differences in the marginal fit among the groups except that the Cercon crowns had significantly smaller marginal gaps than the Lava crowns (P<0.001.  Conclusions. Within the limitation of this study, all the metal-free restorations made by the digital CAD/CAM systems had clinically acceptable marginal accuracy.

  4. Curves and surfaces for computer-aided geometric design a practical guide

    CERN Document Server

    Farin, Gerald

    1992-01-01

    A leading expert in CAGD, Gerald Farin covers the representation, manipulation, and evaluation of geometric shapes in this the Third Edition of Curves and Surfaces for Computer Aided Geometric Design. The book offers an introduction to the field that emphasizes Bernstein-Bezier methods and presents subjects in an informal, readable style, making this an ideal text for an introductory course at the advanced undergraduate or graduate level.The Third Edition includes a new chapter on Topology, offers new exercises and sections within most chapters, combines the material on Geometric Continuity i

  5. Generic Mathematical Programming Formulation and Solution for Computer-Aided Molecular Design

    DEFF Research Database (Denmark)

    Zhang, Lei; Cignitti, Stefano; Gani, Rafiqul

    2015-01-01

    This short communication presents a generic mathematical programming formulation for Computer-Aided Molecular Design (CAMD). A given CAMD problem, based on target properties, is formulated as a Mixed Integer Linear/Non-Linear Program (MILP/MINLP). The mathematical programming model presented here......, which is formulated as an MILP/MINLP problem, considers first-order and second-order molecular groups for molecular structure representation and property estimation. It is shown that various CAMD problems can be formulated and solved through this model....

  6. Generic Mathematical Programming Formulation and Solution for Computer-Aided Molecular Design

    DEFF Research Database (Denmark)

    Zhang, Lei; Cignitti, Stefano; Gani, Rafiqul

    2015-01-01

    This short communication presents a generic mathematical programming formulation for Computer-Aided Molecular Design (CAMD). A given CAMD problem, based on target properties, is formulated as a Mixed Integer Linear/Non-Linear Program (MILP/MINLP). The mathematical programming model presented here......, which is formulated as an MILP/MINLP problem, considers first-order and second-order molecular groups for molecular structure representation and property estimation. It is shown that various CAMD problems can be formulated and solved through this model....

  7. A Simple and Resource-efficient Setup for the Computer-aided Drug Design Laboratory.

    Science.gov (United States)

    Moretti, Loris; Sartori, Luca

    2016-10-01

    Undertaking modelling investigations for Computer-Aided Drug Design (CADD) requires a proper environment. In principle, this could be done on a single computer, but the reality of a drug discovery program requires robustness and high-throughput computing (HTC) to efficiently support the research. Therefore, a more capable alternative is needed but its implementation has no widespread solution. Here, the realization of such a computing facility is discussed, from general layout to technical details all aspects are covered. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Implementation of Locally Weighted Projection Regression Network for Concurrency Control In Computer Aided Design

    Directory of Open Access Journals (Sweden)

    A.Muthukumaravel

    2011-08-01

    Full Text Available This paper presents implementation of locally weighted projection regression (LWPR network method for concurrency control while developing dial of a fork using Autodesk inventor 2008. The LWPR learns the objects and the type of transactions to be done based on which node in the output layer of the network exceeds a threshold value. Learning stops once all the objects are exposed to LWPR. During testing performance, metrics are analyzed. We have attempted to use LWPR for storing lock information when multi users are working on computer Aided Design (CAD. The memory requirements of the proposed method are minimal in processing locks during transaction.

  9. Research on the Procedure for Computer-Aided Pattern Design of Uygur's Flowered Hats

    OpenAIRE

    Shuxian Liu; Xiaohua Li

    2013-01-01

    Xinjiang Uygur’s flowered hats is famous all over the world, it leads the world of headwear of variou nationalities within China by the variety of styles, the various ways of how to emroider pattern design and exquisite manufacture. It is unusual even in national costumes art of the world. The poupose of this study is to analyze Uygur's headwear, study the rules of Uygur's headwear pattern, analyze the characteristic of the basic pattern, research on the procedure for computer-aided pattern d...

  10. Advanced computer-aided intraoperative technologies for information-guided surgical management of gliomas: Tokyo Women's Medical University experience.

    Science.gov (United States)

    Iseki, H; Nakamura, R; Muragaki, Y; Suzuki, T; Chernov, M; Hori, T; Takakura, K

    2008-10-01

    The availability of the intraoperative MRI and real-time neuronavigation has dramatically changed the principles of surgery for gliomas. Current intraoperative computer-aided technologies permit perfect localization of the neoplasm, precise estimation of its volume, and clear definition of its interrelationships with the eloquent brain structures. This allows maximal tumor resection with minimal risk of postoperative disabilities. Under such conditions the medical treatment has become significantly dependent on the quality of the provided information and can be designated as information-guided management. Therefore, appropriate management of the wide spectrum of the intraoperative medical data and its adequate distribution between members of the surgical team for facilitation of the clinical decision-making is very important for attainment of the best possible outcome. Further progress in advanced neurovisualization, robotics, and comprehensive medical information technology has a great potential to increase the safety of the neurosurgical procedures for parenchymal brain tumors in the eloquent brain areas.

  11. Towards Building a Computer Aided Education System for Special Students Using Wearable Sensor Technologies

    Directory of Open Access Journals (Sweden)

    Raja Majid Mehmood

    2017-02-01

    Full Text Available Human computer interaction is a growing field in terms of helping people in their daily life to improve their living. Especially, people with some disability may need an interface which is more appropriate and compatible with their needs. Our research is focused on similar kinds of problems, such as students with some mental disorder or mood disruption problems. To improve their learning process, an intelligent emotion recognition system is essential which has an ability to recognize the current emotional state of the brain. Nowadays, in special schools, instructors are commonly use some conventional methods for managing special students for educational purposes. In this paper, we proposed a novel computer aided method for instructors at special schools where they can teach special students with the support of our system using wearable technologies.

  12. Towards Building a Computer Aided Education System for Special Students Using Wearable Sensor Technologies.

    Science.gov (United States)

    Mehmood, Raja Majid; Lee, Hyo Jong

    2017-02-08

    Human computer interaction is a growing field in terms of helping people in their daily life to improve their living. Especially, people with some disability may need an interface which is more appropriate and compatible with their needs. Our research is focused on similar kinds of problems, such as students with some mental disorder or mood disruption problems. To improve their learning process, an intelligent emotion recognition system is essential which has an ability to recognize the current emotional state of the brain. Nowadays, in special schools, instructors are commonly use some conventional methods for managing special students for educational purposes. In this paper, we proposed a novel computer aided method for instructors at special schools where they can teach special students with the support of our system using wearable technologies.

  13. Procafd: Computer Aided Tool for Synthesis-Design & Analysis of Chemical Process Flowsheets

    DEFF Research Database (Denmark)

    Kumar Tula, Anjan; Eden, Mario R.; Gani, Rafiqul

    2015-01-01

    In practice, chemical process synthesis-design involves identification of the processing route to reach a desired product from a specified set of raw materials, design of the operations involved in the processing route, the calculations of utility requirements, the calculations of waste...... are synthesized to form molecules in computer-aided molecular design (CAMD) techniques [4]. The main idea here was to apply the principle of group-contribution approach from chemical property estimation to the synthesis and design of chemical process flowsheets. That is, use process-groups representing different...... of mathematical programming techniques, (c) hybrid approach which combine two or more approaches. D’Anterroches [3] proposed a group contribution based hybrid approach to solve the synthesis-design problem where, chemical process flowsheets could be synthesized in the same way as atoms or groups of atoms...

  14. A Systematic Computer-Aided Framework for Integrated Design and Control of Chemical Processes

    DEFF Research Database (Denmark)

    Mansouri, Seyed Soheil; Sales-Cruz, Mauricio; Huusom, Jakob Kjøbsted

    Chemical processes are conventionally designed through a sequential approach. In this sequential approach, first, a steady-state process design is obtained and then, control structure synthesis that, in most of the cases, is based on heuristics is performed. Therefore, process design and process......-defined operational conditions whereas controllability is considered to maintain desired operating points of the process at any kind of imposed disturbance under normal operating conditions. In this work, a systematic hierarchical computer-aided framework for integrated process design and control of chemical...... control and operation considerations have been studied independently. Furthermore, this sequential approach does not adequately answer this question, “How process design decisions influence process control and operation?”. In order to answer this question, it is necessary to consider process...

  15. Dynamic light as a transformational tool in computer-aided design

    DEFF Research Database (Denmark)

    Hansen, Ellen Kathrine; Mullins, Michael Finbarr; Triantafyllidis, Georgios

    2016-01-01

    , the process and tools can be grouped in the following five domains: 1. Transfer. Knowledge from different disciplines is collected, transferred, reviewed and coded into a common language. 2. Translate. The knowledge from the different fields is translated and investigated through experiments. Rapid prototype...... to develop mixed research and design methods, where computer aided design tools used in physical and virtual experiments assist the transdisciplinary design process. The task is to discover a sequence of processes and tools that support each other and lead to innovative design solutions produced from...... as a transformational design tool is perhaps one of the most non-destructive, reversible and gentle ways to transform and redefine architecture and spaces. The case studied is a particular urban and architectural challenge represented by an urban church building, which had fallen into disuse. The building was acquired...

  16. Computer Aided Drug Design Studies in the Discovery of Secondary Metabolites Targeted Against Age-Related Neurodegenerative Diseases.

    Science.gov (United States)

    Scotti, Luciana; Scotti, Marcus Tullius

    2015-01-01

    Secondary metabolites are plant products that occur usually in differentiated cells, generally not being necessary for the cells themselves, but likely useful for the plant as a whole. Neurodegeneration can be found in many different levels in the neurons, it always begins at the molecular level and progresses toward the systemic levels. Usually, alterations are observed such as decreasing cholinergic impulse, toxicity related to reactive oxygen species (ROS, inflammatory "amyloid plaque" related processes, catecholamine disequilibrium, etc. Computer aided drug design (CADD has become relevant in the drug discovery process; technological advances in the areas of molecular structure characterization, computational science, and molecular biology have contributed to the planning of new drugs against neurodegenerative diseases. This review discusses scientific CADD studies of the secondary metabolites. Flavonoids, alkaloids, and xanthone compounds have been studied by various researchers (as inhibitory ligands in molecular docking; mainly with three enzymes: acetylcholinesterase (AChE; EC 3.1.1.7, butyrylcholinesterase (BChE; EC 3.1.1.8, and monoamine oxidase (MAO; EC 1.4.3.4. In addition, we have applied ligand-based-virtual screening (using Random Forest, associated with structure-based- virtual screening (docking of a small dataset of 469 alkaloids of the Apocynaceae family from an in-house data bank to select structures with potential inhibitory activity against human AChE. This computer-aided drug design study selected certain alkaloids that might be useful in further studies for the treatment of neurological disorders such as Alzheimer's and Parkinson's disease.

  17. Computer-aided Molecular Design of Compounds Targeting Histone Modifying Enzymes.

    Science.gov (United States)

    Andreoli, Federico; Del Rio, Alberto

    2015-01-01

    Growing evidences show that epigenetic mechanisms play crucial roles in the genesis and progression of many physiopathological processes. As a result, research in epigenetic grew at a fast pace in the last decade. In particular, the study of histone post-translational modifications encountered an extraordinary progression and many modifications have been characterized and associated to fundamental biological processes and pathological conditions. Histone modifications are the catalytic result of a large set of enzyme families that operate covalent modifications on specific residues at the histone tails. Taken together, these modifications elicit a complex and concerted processing that greatly contribute to the chromatin remodeling and may drive different pathological conditions, especially cancer. For this reason, several epigenetic targets are currently under validation for drug discovery purposes and different academic and industrial programs have been already launched to produce the first pre-clinical and clinical outcomes. In this scenario, computer-aided molecular design techniques are offering important tools, mainly as a consequence of the increasing structural information available for these targets. In this mini-review we will briefly discuss the most common types of known histone modifications and the corresponding operating enzymes by emphasizing the computer-aided molecular design approaches that can be of use to speed-up the efforts to generate new pharmaceutically relevant compounds.

  18. Design-based approach to ethics in computer-aided diagnosis

    Science.gov (United States)

    Collmann, Jeff R.; Lin, Jyh-Shyan; Freedman, Matthew T.; Wu, Chris Y.; Hayes, Wendelin S.; Mun, Seong K.

    1996-04-01

    A design-based approach to ethical analysis examines how computer scientists, physicians and patients make and justify choices in designing, using and reacting to computer-aided diagnosis (CADx) systems. The basic hypothesis of this research is that values are embedded in CADx systems during all phases of their development, not just retrospectively imposed on them. This paper concentrates on the work of computer scientists and physicians as they attempt to resolve central technical questions in designing clinically functional CADx systems for lung cancer and breast cancer diagnosis. The work of Lo, Chan, Freedman, Lin, Wu and their colleagues provides the initial data on which this study is based. As these researchers seek to increase the rate of true positive classifications of detected abnormalities in chest radiographs and mammograms, they explore dimensions of the fundamental ethical principal of beneficence. The training of CADx systems demonstrates the key ethical dilemmas inherent in their current design.

  19. Computer aided process planning and die design in simulation environment in sheet metal forming

    Science.gov (United States)

    Tisza, Miklós; Lukács, Zsolt

    2013-12-01

    During the recent 10-15 years, Computer Aided Process Planning and Die Design evolved as one of the most important engineering tools in sheet metal forming, particularly in the automotive industry. This emerging role is strongly emphasized by the rapid development of Finite Element Modeling, as well. The purpose of this paper is to give a general overview about the recent achievements in this very important field of sheet metal forming and to introduce some special results in this development activity. Therefore, in this paper, an integrated process simulation and die design system developed at the University of Miskolc, Department of Mechanical Engineering will be analyzed. The proposed integrated solutions have great practical importance to improve the global competitiveness of sheet metal forming in the very important segment of industry. The concept described in this paper may have specific value both for process planning and die design engineers.

  20. An integrated computer aided system for integrated design of chemical processes

    DEFF Research Database (Denmark)

    Gani, Rafiqul; Hytoft, Glen; Jaksland, Cecilia

    1997-01-01

    In this paper, an Integrated Computer Aided System (ICAS), which is particularly suitable for solving problems related to integrated design of chemical processes; is presented. ICAS features include a model generator (generation of problem specific models including model simplification and model...... reduction), a simulator (use of problem specific simulation strategies for steady state and dynamic simulation), toolboxes (thermodynamic toolbox, synthesis toolbox, control toolbox, design toolbox and analysis toolbox), and an interface for problem defintion. Each toolbox solves aspecific set of problems...... and communicates with all other computational tools available in ICAS. A large range of thermodynamic models for estimation of the necessary thermo-physical properties, a large range of computational algorithms for determination of various types of phase diagrams, algorithms for process synthesis, design, control...

  1. A Novel Computer-Aided Approach for Parametric Investigation of Custom Design of Fracture Fixation Plates.

    Science.gov (United States)

    Chen, Xiaozhong; He, Kunjin; Chen, Zhengming

    2017-01-01

    The present study proposes an integrated computer-aided approach combining femur surface modeling, fracture evidence recover plate creation, and plate modification in order to conduct a parametric investigation of the design of custom plate for a specific patient. The study allows for improving the design efficiency of specific plates on the patients' femur parameters and the fracture information. Furthermore, the present approach will lead to exploration of plate modification and optimization. The three-dimensional (3D) surface model of a detailed femur and the corresponding fixation plate were represented with high-level feature parameters, and the shape of the specific plate was recursively modified in order to obtain the optimal plate for a specific patient. The proposed approach was tested and verified on a case study, and it could be helpful for orthopedic surgeons to design and modify the plate in order to fit the specific femur anatomy and the fracture information.

  2. A Novel Computer-Aided Approach for Parametric Investigation of Custom Design of Fracture Fixation Plates

    Science.gov (United States)

    2017-01-01

    The present study proposes an integrated computer-aided approach combining femur surface modeling, fracture evidence recover plate creation, and plate modification in order to conduct a parametric investigation of the design of custom plate for a specific patient. The study allows for improving the design efficiency of specific plates on the patients' femur parameters and the fracture information. Furthermore, the present approach will lead to exploration of plate modification and optimization. The three-dimensional (3D) surface model of a detailed femur and the corresponding fixation plate were represented with high-level feature parameters, and the shape of the specific plate was recursively modified in order to obtain the optimal plate for a specific patient. The proposed approach was tested and verified on a case study, and it could be helpful for orthopedic surgeons to design and modify the plate in order to fit the specific femur anatomy and the fracture information. PMID:28203270

  3. Design of tailor-made chemical blend using a decomposition-based computer-aided approach

    DEFF Research Database (Denmark)

    Yunus, Nor Alafiza; Gernaey, Krist; Manan, Z.A.

    2011-01-01

    method reduces the search space in a systematic manner and the general blend design problem is decomposed into two stages. The first stage investigates the mixture stability where all unstable mixtures are eliminated and the stable blend candidates are retained for further testing (note that all blends...... attributes (properties).The systematic computer-aided technique first establishes the search space, and then narrows it down in subsequent steps until a small number of feasible and promising candidates remain. At this point, experimental work may be conducted to verify if any or all the candidates satisfy...... and their compositions and a set of desired target properties of the blended product as design constraints. This blend design problem is solved using a decomposition approach, which eliminates infeasible and/or redundant candidates gradually through a hierarchy of (property) model based constraints. This decomposition...

  4. Effect of different adhesive strategies on microtensile bond strength of computer aided design/computer aided manufacturing blocks bonded to dentin

    Science.gov (United States)

    Roperto, Renato; Akkus, Anna; Akkus, Ozan; Lang, Lisa; Sousa-Neto, Manoel Damiao; Teich, Sorin; Porto, Thiago Soares

    2016-01-01

    Background: The aim of this study was to determine the microtensile bond strength (μTBS) of ceramic and composite computer aided design-computer aided manufacturing (CAD-CAM) blocks bonded to dentin using different adhesive strategies. Materials and Methods: In this in vitro study, 30 crowns of sound freshly extracted human molars were sectioned horizontally 3 mm above the cementoenamel junction to produce flat dentin surfaces. Ceramic and composite CAD/CAM blocks, size 14, were sectioned into slices of 3 mm thick. Before bonding, CAD/CAM block surfaces were treated according to the manufacturer's instructions. Groups were created based on the adhesive strategy used: Group 1 (GI) - conventional resin cement + total-etch adhesive system, Group 2 (GII) - conventional resin cement + self-etch adhesive system, and Group 3 (GIII) - self-adhesive resin cement with no adhesive. Bonded specimens were stored in 100% humidity for 24h at 37΀C, and then sectioned with a slow-speed diamond saw to obtain 1 mm × 1 mm × 6 mm microsticks. Microtensile testing was then conducted using a microtensile tester. μTBS values were expressed in MPa and analyzed by one-way ANOVA with post hoc (Tukey) test at the 5% significance level. Results: Mean values and standard deviations of μTBS (MPa) were 17.68 (±2.71) for GI/ceramic; 17.62 (±3.99) for GI/composite; 13.61 (±6.92) for GII/composite; 12.22 (±4.24) for GII/ceramic; 7.47 (±2.29) for GIII/composite; and 6.48 (±3.10) for GIII/ceramic; ANOVA indicated significant differences among the adhesive modality and block interaction (P ceramic. Bond strength of GIII was consistently lower (P ceramic, can be significantly affected by different adhesive strategies used. PMID:27076825

  5. Evaluation of three-dimensional position change of the condylar head after orthognathic surgery using computer-aided design/computer-aided manufacturing-made condyle positioning jig.

    Science.gov (United States)

    Kim, Hyung-Mo; Baek, Seung-Hak; Kim, Tae-Yun; Choi, Jin-Young

    2014-11-01

    This study was performed to evaluate the efficacy of computer-aided design/computer-aided manufacturing (CAM/CAD)-made condyle positioning jig in orthognathic surgery. The sample consisted of 40 mandibular condyles of 20 patients with class III malocclusion who underwent bilateral sagittal split ramus osteotomy with semirigid fixation (6 men and 14 women; mean age, 25 y; mean amount of mandibular setback, 5.8 mm). Exclusion criteria were patients who needed surgical correction of the frontal ramal inclination and had signs and symptoms of the temporomandibular disorder before surgery. Three-dimensional computed tomograms were taken 1 month before the surgery (T1) and 1 day after the surgery (T2). The condylar position was evaluated at the T1 and T2 stages on the axial, frontal, and sagittal aspects in the three-dimensional coordinates. The linear change of the posterior border of the proximal segment of the ramus between T1 and T2 was also evaluated in 30 condyles (15 patients), with the exception of 10 condyles of 5 patients who received mandibular angle reduction surgery. There was no significant difference in the condylar position in the frontal and sagittal aspects (P > 0.05). Although there was a significant difference in the condylar position in the axial aspect (P < 0.01), the amount of difference was less than 1 mm and 1 degree; it can be considered clinically nonsignificant. In the linear change of the posterior border of the proximal segment of the ramus, the mean change was 1.4 mm and 60% of the samples showed a minimal change of less than 1 mm. The results of this study suggest that CAD/CAM-made condyle positioning jig is easy to install and reliable to use in orthognathic surgery.

  6. Interface load analysis for computer-aided design of below-knee prosthetic sockets.

    Science.gov (United States)

    Reynolds, D P; Lord, M

    1992-07-01

    A finite-element analysis is made for the compression of soft tissues of the residual lower limb contained in a prosthetic socket. The analysis is relevant to static loading during stance in a patellar-tendon-bearing, below-knee design of socket. Values of Young's modulus are obtained experimentally for use in the model. One of the main objectives is to study the sensitivity of the loading to these values and also to other assumed conditions. Using direct pressure at the limb/socket interface and vertical stiffness as indicators, changes in material properties, socket alignment and socket rectification are investigated; assumptions about the frictional characteristic at the interface are seen to be critical in determination of load distribution. This type of analysis may provide the next stage of refinement for computer-aided socket design systems.

  7. Computer-aided design model for anaerobic-phased-solids digester system

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Z.; Zhang, R. [University of California, Davis, CA (United States); Tiangco, V. [California Energy Commission, Sacramento, CA (United States)

    1999-07-01

    The anaerobic-phased-solids (APS) digester system is a newly developed anaerobic digestion system for converting solid wastes, such as crop residues and food wastes, into biogas for power and heat generation. A computer-aided engineering design model has been developed to design the APS-digester system and study the heat transfer from the reactors and energy production of the system. Simulation results of a case study are presented by using the model to predict the heating energy requirement and biogas energy production for anaerobic digestion of garlic waste. The important factors, such as environmental conditions, insulation properties, and characteristics of the wastes, on net energy production are also investigated. (author)

  8. Automated a complex computer aided design concept generated using macros programming

    Science.gov (United States)

    Rizal Ramly, Mohammad; Asrokin, Azharrudin; Abd Rahman, Safura; Zulkifly, Nurul Ain Md

    2013-12-01

    Changing a complex Computer Aided design profile such as car and aircraft surfaces has always been difficult and challenging. The capability of CAD software such as AutoCAD and CATIA show that a simple configuration of a CAD design can be easily modified without hassle, but it is not the case with complex design configuration. Design changes help users to test and explore various configurations of the design concept before the production of a model. The purpose of this study is to look into macros programming as parametric method of the commercial aircraft design. Macros programming is a method where the configurations of the design are done by recording a script of commands, editing the data value and adding a certain new command line to create an element of parametric design. The steps and the procedure to create a macro programming are discussed, besides looking into some difficulties during the process of creation and advantage of its usage. Generally, the advantages of macros programming as a method of parametric design are; allowing flexibility for design exploration, increasing the usability of the design solution, allowing proper contained by the model while restricting others and real time feedback changes.

  9. Computer-aided design of control systems to meet many requirements

    Science.gov (United States)

    Schy, A. A.; Adams, W. M., Jr.; Johnson, K. G.

    1974-01-01

    A method is described for using nonlinear programing in the computer-aided design of airplane control systems. It is assumed that the quality of such systems depends on many criteria. These criteria are included in the constraints vector (instead of attempting to combine them into a single scalar criterion, as is usually done), and the design proceeds through a sequence of nonlinear programing solutions in which the designer varies the specification of sets of requirements levels. The method is applied to design of a lateral stability augmentation system (SAS) for a fighter airplane, in which the requirements vector is chosen from the official handling qualities specifications. Results are shown for several simple SAS configurations designed to obtain desirable handling qualities over all design flight conditions with minimum feedback gains. The choice of the final design for each case is not unique but depends on the designer's decision as to which achievable set of requirements levels represents the best for that system. Results indicate that it may be possible to design constant parameter SAS which can satisfy the most stringent handling qualities requirements for fighter airplanes in all flight conditions. The role of the designer as a decision maker, interacting with the computer program, is discussed. Advantages of this type of designer-computer interaction are emphasized. Desirable extensions of the method are indicated.

  10. Chromatofocusing using micropellicular column packings with computer-aided design of the elution buffer composition.

    Science.gov (United States)

    Kang, Xuezhen; Frey, Douglas D

    2002-03-01

    Micropellicular, anion-exchange column packings are used in chromatofocusing to demonstrate the resolution and speed achieved when proteins are separated under these conditions. Linear or concave pH gradients are produced with simple mixtures containing four or fewer individual buffering species instead of the more commonly used polyampholyte buffers. Computer-aided design methods are demonstrated for selecting the composition of the elution buffer to produce a pH gradient of a desired shape. The method is applied to high-resolution, analytical- and preparative-scale separations involving horse myoglobin, human hemoglobin variants, and bovine carbonic anhydrase. A useful selection of buffering species is described capable of producing pH gradients of a variety of shapes in the range between pH 9.5 and 5.5.

  11. Validation of space/ground antenna control algorithms using a computer-aided design tool

    Science.gov (United States)

    Gantenbein, Rex E.

    1995-01-01

    The validation of the algorithms for controlling the space-to-ground antenna subsystem for Space Station Alpha is an important step in assuring reliable communications. These algorithms have been developed and tested using a simulation environment based on a computer-aided design tool that can provide a time-based execution framework with variable environmental parameters. Our work this summer has involved the exploration of this environment and the documentation of the procedures used to validate these algorithms. We have installed a variety of tools in a laboratory of the Tracking and Communications division for reproducing the simulation experiments carried out on these algorithms to verify that they do meet their requirements for controlling the antenna systems. In this report, we describe the processes used in these simulations and our work in validating the tests used.

  12. Computer-aided molecular design of solvents for accelerated reaction kinetics.

    Science.gov (United States)

    Struebing, Heiko; Ganase, Zara; Karamertzanis, Panagiotis G; Siougkrou, Eirini; Haycock, Peter; Piccione, Patrick M; Armstrong, Alan; Galindo, Amparo; Adjiman, Claire S

    2013-11-01

    Solvents can significantly alter the rates and selectivity of liquid-phase organic reactions, often hindering the development of new synthetic routes or, if chosen wisely, facilitating routes by improving rates and selectivities. To address this challenge, a systematic methodology is proposed that quickly identifies improved reaction solvents by combining quantum mechanical computations of the reaction rate constant in a few solvents with a computer-aided molecular design (CAMD) procedure. The approach allows the identification of a high-performance solvent within a very large set of possible molecules. The validity of our CAMD approach is demonstrated through application to a classical nucleophilic substitution reaction for the study of solvent effects, the Menschutkin reaction. The results were validated successfully by in situ kinetic experiments. A space of 1,341 solvents was explored in silico, but required quantum-mechanical calculations of the rate constant in only nine solvents, and uncovered a solvent that increases the rate constant by 40%.

  13. Alzheimer's disease drug development based on Computer-Aided Drug Design.

    Science.gov (United States)

    Zeng, Huahui; Wu, Xiangxiang

    2016-10-04

    Alzheimer's disease (AD) is a common neurodegenerative disorder characterized by the excessive deposition of amyloids in the brain. The pathological features mainly include the extracellular amyloid plaques and intracellular neurofibrillary tangles, which are the production of amyloid precursor protein (APP) processed by the α-, β- and γ-secretases. Based on the amyloid cascade hypotheses of AD, a large number of amyloid-β agents and secretase inhibitors against AD have been recently developed by using computational methods. This review article describes pathophysiology of AD and the structure of the Aβ plaques, β- and γ-secretases, and discusses the recent advances in the development of the amyloid agents for AD therapy and diagnosis by using Computer-Aided Drug Design approach.

  14. An evaluation of computer aided design of below-knee prosthetic sockets.

    Science.gov (United States)

    Topper, A K; Fernie, G R

    1990-12-01

    Forty-eight below-knee amputees compared sockets designed using CANFIT computer aided design (CAD) software with sockets designed using conventional methods. Each subject was fitted by one prosthetist who used conventional techniques and one who used the CANFIT system to design the socket. Prosthetists alternated design methods for each new subject. The prosthetist using the conventional techniques was allowed up to 2 design attempts and the prosthetist using the CANFIT system was allowed up to 5 design attempts. After 2 design attempts with each method 21% of the subjects preferred the CANFIT design socket. Following up to 5 attempts 54% preferred the CANFIT designed socket. A jury of experts made an assessment of the CANFIT system and of CAD in prosthetics. The jury did not think that the version of the system tested was cost effective but that at the rate that it was improving it would become such within 3 to 5 years. The jury noted that, as well as monetary benefits, CAD presents the possibility of benefits in other areas such as research and teaching. A number of specific suggestions regarding the use and development of CAD in prosthetics were also made.

  15. An overlooked yet ubiquitous fluoride congenitor: binding bifluoride in triazolophanes using computer-aided design.

    Science.gov (United States)

    Ramabhadran, Raghunath O; Liu, Yun; Hua, Yuran; Ciardi, Moira; Flood, Amar H; Raghavachari, Krishnan

    2014-04-01

    Despite its ubiquity during the binding and sensing of fluoride, the role of bifluoride (HF2(-)) and its binding properties are almost always overlooked. Here, we give one of the first examinations of bifluoride recognition in which we use computer-aided design to modify the cavity shape of triazolophanes to better match with HF2(-). Computational investigation indicates that HF2(-) and Cl(-) should have similar binding affinities to the parent triazolophane in the gas phase. Evaluation of the binding geometries revealed a preference for binding of the linear HF2(-) along the north-south axis with a smaller Boltzmann weighted population aligned east-west and all states being accessed rapidly through in-plane precessional rotations of the anion. While the (1)H NMR spectroscopy studies are consistent with the calculated structural aspects, binding affinities in solution were determined to be significantly smaller for the bifluoride than the chloride. Computed geometries suggested that a 20° tilting of the bifluoride (stemming from the cavity size) could account for the 25-fold difference between the two binding affinities, HF2(-) bifluoride's binding affinity (K ∼ 10(6) M(-1)) increased and was also found to remain equal to chloride in the gas and solution phases. The new oblate cavity appeared to hold the HF2(-) in a single east-west arrangement. Our findings demonstrate the promising ability of computer-aided design to fine-tune the structural and electronic match in anion receptors as a means to control the arrangement and binding strength of a desired guest.

  16. Opportunities for Russian Nuclear Weapons Institute developing computer-aided design programs for pharmaceutical drug discovery. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-09-23

    The goal of this study is to determine whether physicists at the Russian Nuclear Weapons Institute can profitably service the need for computer aided drug design (CADD) programs. The Russian physicists` primary competitive advantage is their ability to write particularly efficient code able to work with limited computing power; a history of working with very large, complex modeling systems; an extensive knowledge of physics and mathematics, and price competitiveness. Their primary competitive disadvantage is their lack of biology, and cultural and geographic issues. The first phase of the study focused on defining the competitive landscape, primarily through interviews with and literature searches on the key providers of CADD software. The second phase focused on users of CADD technology to determine deficiencies in the current product offerings, to understand what product they most desired, and to define the potential demand for such a product.

  17. User's manual: Computer-aided design programs for inductor-energy-storage dc-to-dc electronic power converters

    Science.gov (United States)

    Huffman, S.

    1977-01-01

    Detailed instructions on the use of two computer-aided-design programs for designing the energy storage inductor for single winding and two winding dc to dc converters are provided. Step by step procedures are given to illustrate the formatting of user input data. The procedures are illustrated by eight sample design problems which include the user input and the computer program output.

  18. Computer-aided design in power engineering. Application of software tools

    Energy Technology Data Exchange (ETDEWEB)

    Stojkovic, Zlatan

    2012-07-01

    Demonstrates the use software tools in the practice of design in the field of power systems. Presents many applications in the design in the field of power systems. Useful for educative purposes and practical work. This textbooks demonstrates the application of software tools in solving a series of problems from the field of designing power system structures and systems. It contains four chapters: The first chapter leads the reader through all the phases necessary in the procedures of computer aided modeling and simulation. It guides through the complex problems presenting on the basis of eleven original examples. The second chapter presents application of software tools in power system calculations of power systems equipment design. Several design example calculations are carried out using engineering standards like MATLAB, EMTP/ATP, Excel and Access, AutoCAD and Simulink. The third chapters focuses on the graphical documentation using a collection of software tools (AutoCAD, EPLAN, SIMARIS SIVACON, SIMARIS DESIGN) which enable the complete automation of the development of graphical documentation of a power systems. In the fourth chapter, the application of software tools in the project management in power systems is discussed. Here, the emphasis is put on the standard software MS Excel and MS Project.

  19. Computer Aided Design of Transformer Station Grounding System Using CDEGS Software

    Directory of Open Access Journals (Sweden)

    S. Nikolovski

    2004-01-01

    Full Text Available This paper presents a computer-aided design of a transformer station grounding system. Fault conditions in a transformer station can produce huge damage to transformer station equipment if the grounding system is not designed properly. A well designed grounding system is a very important part of the project for transformer station design as a whole. This paper analyses a procedure for transformer grounding system design and spatial distribution of touch and step voltage on the ground surface level, using the CDEGS (Current Distribution Electromagnetic Interference Grounding and Soil Structure Analysis software. Spatial distribution is needed for checking and finding dangerous step and touch voltages above and around the transformer station. Apparent earth resistivity data is measured and analyzed using the RESAP module of the CDEGS software. Because of the very high current flow into the grounding system during a single line to ground fault or a three phase fault in the transformer station, very high and dangerous potentials can be induced on the metallic structures including the fence, which can cause dangerous situations for people and animals near the station and for the personnel inside the station. The PLOT module of CDEGS is used to view the results of the scalar potential, step and touch voltage on the surface. Graphic displays include equipotent contour lines and potential profiles (gradients in 3D and 2D perspective and apparent soil resistivity (Wm versus inter electrode spacing (m. The results of alternative grid designs may be displayed simultaneously for the purpose of comparison.

  20. Designing optimal transportation networks: a knowledge-based computer-aided multicriteria approach

    Energy Technology Data Exchange (ETDEWEB)

    Tung, S.I.

    1986-01-01

    The dissertation investigates the applicability of using knowledge-based expert systems (KBES) approach to solve the single-mode (automobile), fixed-demand, discrete, multicriteria, equilibrium transportation-network-design problem. Previous works on this problem has found that mathematical programming method perform well on small networks with only one objective. Needed is a solution technique that can be used on large networks having multiple, conflicting criteria with different relative importance weights. The KBES approach developed in this dissertation represents a new way to solve network design problems. The development of an expert system involves three major tasks: knowledge acquisition, knowledge representation, and testing. For knowledge acquisition, a computer aided network design/evaluation model (UFOS) was developed to explore the design space. This study is limited to the problem of designing an optimal transportation network by adding and deleting capacity increments to/from any link in the network. Three weighted criteria were adopted for use in evaluating each design alternative: cost, average V/C ratio, and average travel time.

  1. STRATEGY FOR IMPROVEMENT OF SAFETY AND EFFICIENCY OF COMPUTER-AIDED DESIGN ANALYSIS OF CIVIL ENGINEERING STRUCTURES ON THE BASIS OF THE SYSTEM APPROACH

    Directory of Open Access Journals (Sweden)

    Zaikin Vladimir Genrikhovich

    2012-12-01

    Full Text Available The authors highlight three problems of the age of information technologies and proposes the strategy for their resolution in relation to the computer-aided design of civil engineering structures. The authors express their concerns in respect of globalization of software programmes designated for the analysis of civil engineering structures and employed outside of Russia. The problem of the poor quality of the input data has reached Russia. Lately, the rate of accidents of buildings and structures has been growing not only in Russia. Control over efficiency of design projects is hardly performed. This attitude should be changed. Development and introduction of CAD along with the application the efficient methods of projection of behaviour of building structures are in demand. Computer-aided calculations have the function of a logical nucleus, and they need proper control. The system approach to computer-aided calculations and technologies designated for the projection of accidents is formulated by the authors. Two tasks of the system approach and fundamentals of the strategy for its implementation are formulated. The study of cases of negative results of computer-aided design of engineering structures was performed and multi-component design patterns were developed. Conclusions concerning the results of researches aimed at regular and wide-scale implementation of the strategy fundamentals are formulated. Organizational and innovative actions concerning the projected behaviour of civil engineering structures proposed in the strategy are to facilitate: safety and reliability improvement of buildings and structures; saving of building materials and resources; improvement of labour efficiency of designers; modernization and improvement of accuracy of projected behaviour of buildings and building standards; closer ties between civil and building engineering researchers and construction companies; development of competitive environment to boost

  2. Computer Aided Design of the Link-Fork Head-Piston Assembly of the Kaplan Turbine with Solidworks

    Directory of Open Access Journals (Sweden)

    Camelia Jianu

    2010-10-01

    Full Text Available The paper presents the steps for 3D computer aided design (CAD of the link-fork head-piston assembly of the Kaplan turbine made in SolidWorks.The present paper is a tutorial for a Kaplan turbine assembly 3D geometry, which is dedicated to the Assembly design and Drawing Geometry and Drawing Annotation.

  3. 计算机辅助工业设计技术发展状况与趋势%Development Status and Trends of Computer-aided Industrial Design Technology

    Institute of Scientific and Technical Information of China (English)

    马鹏鑫

    2012-01-01

    随着时代的不断发展,技术的不断更新,计算机已经不仅仅是人们在生活中越来越重要的工具,他同时也是工业设计中非常重要的辅助工具,作为工业辅助技术,它的核心内容为工业设计,重点发展方向为产品设计.自从有了信息技术,世界的经济发展方向发生了非常巨大的变化,市场的竞争也变得越来越激烈.%With the development of times and the update of technology, computers have become the more and more important tool in people's life. It also becomes the important auxiliary tools in industry design. As the industrial auxiliary technology, its core content is the industrial design, focusing on product design. Since the information technology appears, the world economy development direction has changed a lot; the market competition is becoming fiercer.

  4. Computer-Aided Molecular Design of Bis-phosphine Oxide Lanthanide Extractants.

    Science.gov (United States)

    McCann, Billy W; Silva, Nuwan De; Windus, Theresa L; Gordon, Mark S; Moyer, Bruce A; Bryantsev, Vyacheslav S; Hay, Benjamin P

    2016-06-20

    Computer-aided molecular design and high-throughput screening of viable host architectures can significantly reduce the efforts in the design of novel ligands for efficient extraction of rare earth elements. This paper presents a computational approach to the deliberate design of bis-phosphine oxide host architectures that are structurally organized for complexation of trivalent lanthanides. Molecule building software, HostDesigner, was interfaced with molecular mechanics software, PCModel, providing a tool for generating and screening millions of potential R2(O)P-link-P(O)R2 ligand geometries. The molecular mechanics ranking of ligand structures is consistent with both the solution-phase free energies of complexation obtained with density functional theory and the performance of known bis-phosphine oxide extractants. For the case where the link is -CH2-, evaluation of the ligand geometry provides the first characterization of a steric origin for the "anomalous aryl strengthening" effect. The design approach has identified a number of novel bis-phosphine oxide ligands that are better organized for lanthanide complexation than previously studied examples.

  5. Role of computer-aided drug design in modern drug discovery.

    Science.gov (United States)

    Macalino, Stephani Joy Y; Gosu, Vijayakumar; Hong, Sunhye; Choi, Sun

    2015-09-01

    Drug discovery utilizes chemical biology and computational drug design approaches for the efficient identification and optimization of lead compounds. Chemical biology is mostly involved in the elucidation of the biological function of a target and the mechanism of action of a chemical modulator. On the other hand, computer-aided drug design makes use of the structural knowledge of either the target (structure-based) or known ligands with bioactivity (ligand-based) to facilitate the determination of promising candidate drugs. Various virtual screening techniques are now being used by both pharmaceutical companies and academic research groups to reduce the cost and time required for the discovery of a potent drug. Despite the rapid advances in these methods, continuous improvements are critical for future drug discovery tools. Advantages presented by structure-based and ligand-based drug design suggest that their complementary use, as well as their integration with experimental routines, has a powerful impact on rational drug design. In this article, we give an overview of the current computational drug design and their application in integrated rational drug development to aid in the progress of drug discovery research.

  6. Development of a computer-aided design software for dental splint in orthognathic surgery

    Science.gov (United States)

    Chen, Xiaojun; Li, Xing; Xu, Lu; Sun, Yi; Politis, Constantinus; Egger, Jan

    2016-12-01

    In the orthognathic surgery, dental splints are important and necessary to help the surgeon reposition the maxilla or mandible. However, the traditional methods of manual design of dental splints are difficult and time-consuming. The research on computer-aided design software for dental splints is rarely reported. Our purpose is to develop a novel special software named EasySplint to design the dental splints conveniently and efficiently. The design can be divided into two steps, which are the generation of initial splint base and the Boolean operation between it and the maxilla-mandibular model. The initial splint base is formed by ruled surfaces reconstructed using the manually picked points. Then, a method to accomplish Boolean operation based on the distance filed of two meshes is proposed. The interference elimination can be conducted on the basis of marching cubes algorithm and Boolean operation. The accuracy of the dental splint can be guaranteed since the original mesh is utilized to form the result surface. Using EasySplint, the dental splints can be designed in about 10 minutes and saved as a stereo lithography (STL) file for 3D printing in clinical applications. Three phantom experiments were conducted and the efficiency of our method was demonstrated.

  7. Computer-aided calculating technological dimension chain%计算机辅助求解工艺尺寸链

    Institute of Scientific and Technical Information of China (English)

    胡凤英

    2012-01-01

    Computer-aided analysis and calculation about technologic dimension chain is an indispensably part of CAPP. A soft system of omputer—aided simply conversion system about technologic dimension chain is developed aimed at the condition that technologic standard can not superpose with designing standard, and the steps of establishing and calculating with the help of computer is illustrated through analyzing the concrete instance. The system adds real-time plotting function, has user-friendly interfaces, with the result of a great improvement on velocity and quality of the solution of dimensions chain.%计算机辅助工艺尺寸链的分析与解算是CAPP中不可或缺的一个环节.针对工艺尺寸链计算中工艺基准与设计基准不重合的情况,开发了一套简单的计算机辅助工艺尺寸链换算系统,并通过实例分析说明计算机辅助建立和计算工艺尺寸链的方法和步骤.该系统增加了实时绘图功能,具有友好的用户界面,进一步提高了尺寸链的解算速度和质量.

  8. Design and Implementation of 3 Axis CNC Router for Computer Aided Manufacturing Courses

    Directory of Open Access Journals (Sweden)

    Aktan Mehmet Emin

    2016-01-01

    Full Text Available In this paper, it is intended to make the mechanical design of 3 axis Computer Numerical Control (CNC router with linear joints, production of electronic control interface cards and drivers and manufacturing of CNC router system which is a combination of mechanics and electronics. At the same time, interface program has been prepared to control router via USB. The router was developed for educational purpose. In some vocational schools and universities, Computer Aided Manufacturing (CAM courses are though rather theoretical. This situation cause ineffective and temporary learning. Moreover, students at schools which have the opportunity to apply for these systems can face with various dangerous accidents. Because of this situation, these students start to get knowledge about this system for the first time. For the first steps of CNC education, using smaller and less dangerous systems will be easier. A new concept CNC machine and its user interface suitable and profitable for education have been completely designed and realized during this study. To test the validity of the hypothesis which the benefits that may exist on the educational life, enhanced traditional education method with the contribution of the designed machine has been practiced on CAM course students for a semester. At the end of the semester, the new method applied students were more successful in the rate of 27.36 percent both in terms of verbal comprehension and exam grades.

  9. Computer-Aided Design of Some Advanced Steels and Cemented Carbides

    Institute of Scientific and Technical Information of China (English)

    LI Lin; ZHANG Mei; HE Yan-lin; De Cooman Bruno; Wollants Patrick

    2005-01-01

    Thermodynamic and kinetic study on TRIP (transformation induced plasticity) steels, cemented carbides and mold steel for plastics were carried out in order to design modern advanced materials. With the sublattice model, equilibrium compositions of ferrite and austenite phases in TRIP steels, as well as volume fraction of austenite at inter-critical temperatures for different time were calculated. Concentration profiles of carbon, manganese, aluminum and silicon in the steels were also estimated in the lattice fixed frame of reference. The effect of Si and Mn on TRIP was discussed according to thermodynamic and kinetic analyses. In order to understand and produce the graded nanophase structure of cemented carbides, miscellaneous phases in the M-Co-C (M= Ti, Ta, Nb) systems and Co-V-C system were modeled. Solution parameters and thermodynamic properties were listed in detail. The improvement of machining behavior of prehardened mould steel for plastics was obtained by computer-aided composition design. The results showed that the matrix composition of large-section prehardened mould steel for plastic markedly influences the precipitation of non-metallic inclusion and the composition control by the aid of Thermo-Calc software package minimizes the amount of detrimental oxide inclusion. In addition, the modification of calcium was optimized in composition design.

  10. Computers in engineering 1983; Proceedings of the International Conference and Exhibit, Chicago, IL, August 7-11, 1983. Volume 1 - Computer-aided design, manufacturing, and simulation

    Science.gov (United States)

    Cokonis, T. J.

    The papers presented in this volume provide examples of the impact of computers on present engineering practice and indicate some future trends in computer-aided design, manufacturing, and simulation. Topics discussed include computer-aided design of turbine cycle configuration, managing and development of engineering computer systems, computer-aided manufacturing with robots in the automotive industry, and computer-aided design/analysis techniques of composite materials in the cure phase. Papers are also presented on computer simulation of vehicular propulsion systems, the performance of a hydraulic system simulator in a CAD environment, and computer simulation of hovercraft heave dynamics and control.

  11. Synthetic tetracycline-inducible regulatory networks: computer-aided design of dynamic phenotypes

    Directory of Open Access Journals (Sweden)

    Kaznessis Yiannis N

    2007-01-01

    Full Text Available Abstract Background Tightly regulated gene networks, precisely controlling the expression of protein molecules, have received considerable interest by the biomedical community due to their promising applications. Among the most well studied inducible transcription systems are the tetracycline regulatory expression systems based on the tetracycline resistance operon of Escherichia coli, Tet-Off (tTA and Tet-On (rtTA. Despite their initial success and improved designs, limitations still persist, such as low inducer sensitivity. Instead of looking at these networks statically, and simply changing or mutating the promoter and operator regions with trial and error, a systematic investigation of the dynamic behavior of the network can result in rational design of regulatory gene expression systems. Sophisticated algorithms can accurately capture the dynamical behavior of gene networks. With computer aided design, we aim to improve the synthesis of regulatory networks and propose new designs that enable tighter control of expression. Results In this paper we engineer novel networks by recombining existing genes or part of genes. We synthesize four novel regulatory networks based on the Tet-Off and Tet-On systems. We model all the known individual biomolecular interactions involved in transcription, translation, regulation and induction. With multiple time-scale stochastic-discrete and stochastic-continuous models we accurately capture the transient and steady state dynamics of these networks. Important biomolecular interactions are identified and the strength of the interactions engineered to satisfy design criteria. A set of clear design rules is developed and appropriate mutants of regulatory proteins and operator sites are proposed. Conclusion The complexity of biomolecular interactions is accurately captured through computer simulations. Computer simulations allow us to look into the molecular level, portray the dynamic behavior of gene regulatory

  12. High School Students' Written Argumentation Qualities with Problem-Based Computer-Aided Material (PBCAM) Designed about Human Endocrine System

    Science.gov (United States)

    Vekli, Gülsah Sezen; Çimer, Atilla

    2017-01-01

    This study investigated development of students' scientific argumentation levels in the applications made with Problem-Based Computer-Aided Material (PBCAM) designed about Human Endocrine System. The case study method was used: The study group was formed of 43 students in the 11th grade of the science high school in Rize. Human Endocrine System…

  13. On the solution of mixed-integer nonlinear programming models for computer aided molecular design.

    Science.gov (United States)

    Ostrovsky, Guennadi M; Achenie, Luke E K; Sinha, Manish

    2002-11-01

    This paper addresses the efficient solution of computer aided molecular design (CAMD) problems, which have been posed as mixed-integer nonlinear programming models. The models of interest are those in which the number of linear constraints far exceeds the number of nonlinear constraints, and with most variables participating in the nonconvex terms. As a result global optimization methods are needed. A branch-and-bound algorithm (BB) is proposed that is specifically tailored to solving such problems. In a conventional BB algorithm, branching is performed on all the search variables that appear in the nonlinear terms. This translates to a large number of node traversals. To overcome this problem, we have proposed a new strategy for branching on a set of linear branchingfunctions, which depend linearly on the search variables. This leads to a significant reduction in the dimensionality of the search space. The construction of linear underestimators for a class of functions is also presented. The CAMD problem that is considered is the design of optimal solvents to be used as cleaning agents in lithographic printing.

  14. Computer aided control engineering

    DEFF Research Database (Denmark)

    Szymkat, Maciej; Ravn, Ole

    1997-01-01

    Current developments in the field of Computer Aided Control Engineering (CACE) have a visible impact on the design methodologies and the structure of the software tools supporting them. Today control engineers has at their disposal libraries, packages or programming environments that may be speci......Current developments in the field of Computer Aided Control Engineering (CACE) have a visible impact on the design methodologies and the structure of the software tools supporting them. Today control engineers has at their disposal libraries, packages or programming environments that may...

  15. An Intelligent Computer-aided Training System (CAT) for Diagnosing Adult Illiterates: Integrating NASA Technology into Workplace Literacy

    Science.gov (United States)

    Yaden, David B., Jr.

    1991-01-01

    An important part of NASA's mission involves the secondary application of its technologies in the public and private sectors. One current application being developed is The Adult Literacy Evaluator, a simulation-based diagnostic tool designed to assess the operant literacy abilities of adults having difficulties in learning to read and write. Using Intelligent Computer-Aided Training (ICAT) system technology in addition to speech recognition, closed-captioned television (CCTV), live video and other state-of-the-art graphics and storage capabilities, this project attempts to overcome the negative effects of adult literacy assessment by allowing the client to interact with an intelligent computer system which simulates real-life literacy activities and materials and which measures literacy performance in the actual context of its use. The specific objectives of the project are as follows: (1) to develop a simulation-based diagnostic tool to assess adults' prior knowledge about reading and writing processes in actual contexts of application; (2) to provide a profile of readers' strengths and weaknesses; and (3) to suggest instructional strategies and materials which can be used as a beginning point for remediation. In the first and development phase of the project, descriptions of literacy events and environments are being written and functional literacy documents analyzed for their components. From these descriptions, scripts are being generated which define the interaction between the student, an on-screen guide and the simulated literacy environment.

  16. Computer-aided design of fragment mixtures for NMR-based screening.

    Directory of Open Access Journals (Sweden)

    Xavier Arroyo

    Full Text Available Fragment-based drug discovery is widely applied both in industrial and in academic screening programs. Several screening techniques rely on NMR to detect binding of a fragment to a target. NMR-based methods are among the most sensitive techniques and have the further advantage of yielding a low rate of false positives and negatives. However, NMR is intrinsically slower than other screening techniques; thus, to increase throughput in NMR-based screening, researchers often assay mixtures of fragments, rather than single fragments. Herein we present a fast and straightforward computer-aided method to design mixtures of fragments taken from a library that have minimized NMR signal overlap. This approach enables direct identification of one or several active fragments without the need for deconvolution. Our approach entails encoding of NMR spectra into a computer-readable format that we call a fingerprint, and minimizing the global signal overlap through a Monte Carlo algorithm. The scoring function used favors a homogenous distribution of the global signal overlap. The method does not require additional experimental work: the only data required are NMR spectra, which are generally recorded for each compound as a quality control measure before its insertion into the library.

  17. Implementation of a tolerance model in a computer aided design and inspection system

    Directory of Open Access Journals (Sweden)

    R. Hunter

    2006-04-01

    Full Text Available Purpose: Purpose of this paper is present a detailed framework to integrate the Computer Aided Design (CAD and Inspection (CAI systems through the integration of the Geometric Dimensioning and Tolerancing (GD&T with the inspection process in coordinate measuring machines (CMMs.Design/methodology/approach: The approach used to develop a prototype of a Knowledge Based System (KBS applied to inspection process establishes a new methodology for integrate the geometric dimensioning and tolerancing (GD&T. The integration is achieved through the definition of the knowledge units for functional properties of GD&T, inspection resources and inspection operations in a common knowledge model. The manufacturing and processing applications are the main topics approach of this paper.Findings: The findings are focused in modeling the features and interactions between knowledge units associated to topology, geometry and tolerances with the inspection process activities. The implementation of the product knowledge model is presented in a computer platform that extracts and represents the GD&T information in a CAI system.Research limitations/implications: The implications are focused on the automation of the inspection process in a KBS application. The future research is focused on the use of artificial intelligent technique, such as genetic algorithms and neural networks, to optimize the time to execute the inspection process.Practical implications: The main outcomes and implication of the KBS prototype application are focused on the reduction of the time spend to develop the inspection process. This KBS application provides the needed information to elaborate this process without the human interface.Originality/value: The original value of this paper is the integration of the design and inspection specification in a unique prototype application. The knowledge model has been defined in a common modeling language (UML and can be implemented in different

  18. A method of computer aided design with self-generative models in NX Siemens environment

    Science.gov (United States)

    Grabowik, C.; Kalinowski, K.; Kempa, W.; Paprocka, I.

    2015-11-01

    Currently in CAD/CAE/CAM systems it is possible to create 3D design virtual models which are able to capture certain amount of knowledge. These models are especially useful in an automation of routine design tasks. These models are known as self-generative or auto generative and they can behave in an intelligent way. The main difference between the auto generative and fully parametric models consists in the auto generative models ability to self-organizing. In this case design model self-organizing means that aside from the possibility of making of automatic changes of model quantitative features these models possess knowledge how these changes should be made. Moreover they are able to change quality features according to specific knowledge. In spite of undoubted good points of self-generative models they are not so often used in design constructional process which is mainly caused by usually great complexity of these models. This complexity makes the process of self-generative time and labour consuming. It also needs a quite great investment outlays. The creation process of self-generative model consists of the three stages it is knowledge and information acquisition, model type selection and model implementation. In this paper methods of the computer aided design with self-generative models in NX Siemens CAD/CAE/CAM software are presented. There are the five methods of self-generative models preparation in NX with: parametric relations model, part families, GRIP language application, knowledge fusion and OPEN API mechanism. In the paper examples of each type of the self-generative model are presented. These methods make the constructional design process much faster. It is suggested to prepare this kind of self-generative models when there is a need of design variants creation. The conducted research on assessing the usefulness of elaborated models showed that they are highly recommended in case of routine tasks automation. But it is still difficult to distinguish

  19. Estimation and Uncertainty Analysis of Flammability Properties for Computer-aided molecular design of working fluids for thermodynamic cycles

    OpenAIRE

    Frutiger, Jerome; Abildskov, Jens; Sin, Gürkan

    2015-01-01

    Computer Aided Molecular Design (CAMD) is an important tool to generate, test and evaluate promising chemical products. CAMD can be used in thermodynamic cycle for the design of pure component or mixture working fluids in order to improve the heat transfer capacity of the system. The safety assessment of novel working fluids relies on accurate property data. Flammability data like the lower and upper flammability limit (LFL and UFL) play an important role in quantifying the risk of fire and e...

  20. An Analysis of Computer Aided Design (CAD) Packages Used at MSFC for the Recent Initiative to Integrate Engineering Activities

    Science.gov (United States)

    Smith, Leigh M.; Parker, Nelson C. (Technical Monitor)

    2002-01-01

    This paper analyzes the use of Computer Aided Design (CAD) packages at NASA's Marshall Space Flight Center (MSFC). It examines the effectiveness of recent efforts to standardize CAD practices across MSFC engineering activities. An assessment of the roles played by management, designers, analysts, and manufacturers in this initiative will be explored. Finally, solutions are presented for better integration of CAD across MSFC in the future.

  1. Computer aided design of prosthetic sockets for below-knee amputees.

    Science.gov (United States)

    Saunders, C G; Foort, J; Bannon, M; Lean, D; Panych, L

    1985-04-01

    A computer-aided sculpting system for use in prosthetics is described. The prosthetist's sculpting tools now consist of a computer, a graphics terminal, a mouse and an on-screen moveable cursor. Accompanied by the system software, these tools allow systematic modification of a primitive socket using techniques analogous to those used by a prosthetist working with rasps and plaster.

  2. Shape sensing for computer aided below-knee prosthetic socket design.

    Science.gov (United States)

    Fernie, G R; Griggs, G; Bartlett, S; Lunau, K

    1985-04-01

    Shape sensing is useful in the computer aided prosthetic fitting process for two purposes. 1. To input characteristic prosthetic shapes that have been developed over the years through the experience of prosthetists. 2. To provide an accurate and rapid measurement of the anatomical shape of the stump. This paper describes two instruments which have been built to meet these objectives.

  3. Pengembangan Model Pembelajaran Project Based Learning pada Mata Kuliah Computer Aided Design

    Directory of Open Access Journals (Sweden)

    Satoto Endar Nayono

    2013-09-01

    Full Text Available One of the key competencies of graduates majoring in Civil Engineering and Planning Education, Faculty of Engineering, Yogyakarta State University (YSU is able to plan buildings. CAD courses aim to train students to be able to pour the planning concepts into the picture. One of the obstacles faced in the course are concepts and pictures that created by the students often do not correspond to the standards used in the field. This study aims to develop a model of project-based learning so that the students’ pictures are more in line with the actual conditions in the field. This study was carried out through the stages as follows: (1 Pre test, (2 Planning of learning, (3 Implementation of the learning model of project-based learning, (4 monitoring and evaluation (5 Reflection and revision, (6 Implementation of learning in the next cycle, and (7 Evaluation of the learning outcomes. This study was conducted for four months in 2012 in the Department of Civil Engineering and Planning Education, Faculty of Engineering, YSU. The subjects of this study are the students who took the course of Computer Aided Design. The analysis of the data used descriptive qualitative and descriptive statistics. The results of this study were: (1 The implementation of project based learning model was proven to increase the learning process and the learning outcomes of students in the subject of CAD through the provision of buildings planning pictures tasks of school buildings based on the real conditions in the field. The task was delivered in every meeting and improved based on the feedback from their lecturers, (2 the learning model of project based learning will be easier to be implemented if it is accompanied by the model of peer tutoring and the learning model of PAIKEM.

  4. Enveloped viruses understood via multiscale simulation: computer-aided vaccine design

    Science.gov (United States)

    Shreif, Z.; Adhangale, P.; Cheluvaraja, S.; Perera, R.; Kuhn, R.; Ortoleva, P.

    Enveloped viruses are viewed as an opportunity to understand how highly organized and functional biosystems can emerge from a collection of millions of chaotically moving atoms. They are an intermediate level of complexity between macromolecules and bacteria. They are a natural system for testing theories of self-assembly and structural transitions, and for demonstrating the derivation of principles of microbiology from laws of molecular physics. As some constitute threats to human health, a computer-aided vaccine and drug design strategy that would follow from a quantitative model would be an important contribution. However, current molecular dynamics simulation approaches are not practical for modeling such systems. Our multiscale approach simultaneously accounts for the outer protein net and inner protein/genomic core, and their less structured membranous material and host fluid. It follows from a rigorous multiscale deductive analysis of laws of molecular physics. Two types of order parameters are introduced: (1) those for structures wherein constituent molecules retain long-lived connectivity (they specify the nanoscale structure as a deformation from a reference configuration) and (2) those for which there is no connectivity but organization is maintained on the average (they are field variables such as mass density or measures of preferred orientation). Rigorous multiscale techniques are used to derive equations for the order parameters dynamics. The equations account for thermal-average forces, diffusion coefficients, and effects of random forces. Statistical properties of the atomic-scale fluctuations and the order parameters are co-evolved. By combining rigorous multiscale techniques and modern supercomputing, systems of extreme complexity can be modeled.

  5. International Conference on Computer Aided Design, Manufacture and Operation in the Marine and Offshore Industries (5th), Incorporating the Ice Technology Workshop (4th) Held in Southampton, United Kingdom on September 13-16, 1994.

    Science.gov (United States)

    ship propulsion . A bridging section on vessels and structures in ice, leads to the second part which is devoted to ice technology. Again, Part II contains some of the papers presented at the fourth meeting on Ice Technology (ITC 94), convened as a workshop during 15th and 16th September. The second part of the book contains sections on ice properties and modelling, as well as ice and ocean

  6. Computer-Aided Drug Design (CADD): Methodological Aspects and Practical Applications in Cancer Research

    Science.gov (United States)

    Gianti, Eleonora

    Computer-Aided Drug Design (CADD) has deservedly gained increasing popularity in modern drug discovery (Schneider, G.; Fechner, U. 2005), whether applied to academic basic research or the pharmaceutical industry pipeline. In this work, after reviewing theoretical advancements in CADD, we integrated novel and stateof- the-art methods to assist in the design of small-molecule inhibitors of current cancer drug targets, specifically: Androgen Receptor (AR), a nuclear hormone receptor required for carcinogenesis of Prostate Cancer (PCa); Signal Transducer and Activator of Transcription 5 (STAT5), implicated in PCa progression; and Epstein-Barr Nuclear Antigen-1 (EBNA1), essential to the Epstein Barr Virus (EBV) during latent infections. Androgen Receptor. With the aim of generating binding mode hypotheses for a class (Handratta, V.D. et al. 2005) of dual AR/CYP17 inhibitors (CYP17 is a key enzyme for androgens biosynthesis and therefore implicated in PCa development), we successfully implemented a receptor-based computational strategy based on flexible receptor docking (Gianti, E.; Zauhar, R.J. 2012). Then, with the ultimate goal of identifying novel AR binders, we performed Virtual Screening (VS) by Fragment-Based Shape Signatures, an improved version of the original method developed in our Laboratory (Zauhar, R.J. et al. 2003), and we used the results to fully assess the high-level performance of this innovative tool in computational chemistry. STAT5. The SRC Homology 2 (SH2) domain of STAT5 is responsible for phospho-peptide recognition and activation. As a keystone of Structure-Based Drug Design (SBDD), we characterized key residues responsible for binding. We also generated a model of STAT5 receptor bound to a phospho-peptide ligand, which was validated by docking publicly known STAT5 inhibitors. Then, we performed Shape Signatures- and docking-based VS of the ZINC database (zinc.docking.org), followed by Molecular Mechanics Generalized Born Surface Area (MMGBSA

  7. Development of problem-oriented software packages for numerical studies and computer-aided design (CAD) of gyrotrons

    Science.gov (United States)

    Damyanova, M.; Sabchevski, S.; Zhelyazkov, I.; Vasileva, E.; Balabanova, E.; Dankov, P.; Malinov, P.

    2016-03-01

    Gyrotrons are the most powerful sources of coherent CW (continuous wave) radiation in the frequency range situated between the long-wavelength edge of the infrared light (far-infrared region) and the microwaves, i.e., in the region of the electromagnetic spectrum which is usually called the THz-gap (or T-gap), since the output power of other devices (e.g., solid-state oscillators) operating in this interval is by several orders of magnitude lower. In the recent years, the unique capabilities of the sub-THz and THz gyrotrons have opened the road to many novel and future prospective applications in various physical studies and advanced high-power terahertz technologies. In this paper, we present the current status and functionality of the problem-oriented software packages (most notably GYROSIM and GYREOSS) used for numerical studies, computer-aided design (CAD) and optimization of gyrotrons for diverse applications. They consist of a hierarchy of codes specialized to modelling and simulation of different subsystems of the gyrotrons (EOS, resonant cavity, etc.) and are based on adequate physical models, efficient numerical methods and algorithms.

  8. Computer-aided design-based high-frequency electromagnetic wave scattering from complex bodies

    Science.gov (United States)

    Baldauf, John Eric

    1991-02-01

    This work investigates the use of high frequency electromagnetic scattering techniques, such as the physical theory of diffraction (PTD) and the geometrical theory of diffraction (GTD) and the shooting and bouncing rays (SBR) method combined with computer aided design (CAD) compatible geometries, to perform the electromagnetic scattering analysis of complex arbitrary bodies. The use of CAD formats such as solid modelled bodies and bodies modelled with triangular patch surface elements allows the scattering analysis of arbitrary bodies which can be constructed using CAD packages. The scattering analyses are applied to radar cross section (RCS) problems, cavity radiation problems, and antenna pattern predictions of complex electrically large structures, thereby showing that it is feasible to accurately approximate the electromagnetic wave scattering from general complex bodies using CAD techniques and high frequency scattering techniques. First, the RCS of large targets which involve multiple geometric optics (GO) interactions are investigated by comparing the RCS calculated using CAD designed radar targets and the SBR method and PTD for targets such as trihedral corner reflectors and an idealized military vehicle model with the experimentally obtained RCS. The comparisons between the calculated and measured results demonstrate that the SBR and PTD can provide accurate approximations of the RCS for targets which have complex multiple GO interactions. Second, the problem of interior cavity radiation for closed cavities is approached using a ray tracing and GO method based on the SBR method and triangular surface patch described geometries. Comparisons between the ray-based calculations and more exact techniques such as the method of moments (MM) for two-dimensional cavities demonstrate that ray-based methods can provide good approximations for the field behavior inside of nonresonant cavities. A three-dimensional case is shown to demonstrate that this technique can be

  9. A systematic framework for computer-aided design of engineering rubber formulations

    Science.gov (United States)

    Ghosh, Prasenjeet

    This thesis considers the design of engineering rubber formulations, whose unique properties of elasticity and resilience enable diverse applications. Engineering rubber formulations are a complex mixture of different materials called curatives that includes elastomers, fillers, crosslinking agents, accelerators, activators, retarders, anti-oxidants and processing aids, where the amount of curatives must be adjusted for each application. The characterization of the final properties of the rubber in application is complex and depends on the chemical interplay between the different curatives in formulation via vulcanization chemistry. The details of the processing conditions and the thermal, deformational, and chemical environment encountered in application also have a pronounced effect on the performance of the rubber. Consequently, for much of the history of rubber as an engineering material, its recipe formulations have been developed largely by trial-and-error, rather than by a fundamental understanding. A computer-aided, systematic and automated framework for the design of such materials is proposed in this thesis. The framework requires the solution to two sub-problems: (a) the forward problem, which involves prediction of the desired properties when the formulation is known and (b) the inverse problem that requires identification of the appropriate formulation, given the desired target properties. As part of the forward model, the chemistry of accelerated sulfur vulcanization is reviewed that permits integration of the knowledge of the past five decades in the literature to answer some old questions, reconcile some of the contradicting mechanisms and present a holistic description of the governing chemistry. Based on this mechanistic chemistry, a fundamental kinetic model is derived using population balance equations. The model quantitatively describes, for the first time, the different aspects of vulcanization chemistry. Subsequently, a novel three

  10. Intelligent computer aided training systems in the real world: Making the technology accessible to the educational mainstream

    Science.gov (United States)

    Kovarik, Madeline

    1993-01-01

    Intelligent computer aided training systems hold great promise for the application of this technology to mainstream education and training. Yet, this technology, which holds such a vast potential impact for the future of education and training, has had little impact beyond the enclaves of government research labs. This is largely due to the inaccessibility of the technology to those individuals in whose hands it can have the greatest impact, teachers and educators. Simply throwing technology at an educator and expecting them to use it as an effective tool is not the answer. This paper provides a background into the use of technology as a training tool. MindLink, developed by HyperTech Systems, provides trainers with a powerful rule-based tool that can be integrated directly into a Windows application. By embedding expert systems technology it becomes more accessible and easier to master.

  11. Application of modern computer-aided technologies in the production of individual bone graft: A case report

    Directory of Open Access Journals (Sweden)

    Mirković Siniša

    2015-01-01

    Full Text Available Introduction. An autologous bone (bone derived from the patient himself is considered to be a “golden standard” in the treatment of bone defects and partial atrophic alveolar ridge. However, large defects and bone losses are difficult to restore in this manner, because extraction of large amounts of autologous tissue can cause donor-site problems. Alternatively, data from computed tomographic (CT scan can be used to shape a precise 3D homologous bone block using a computer-aided design-computer-aided manufacturing (CAD-CAM system. Case report. A 63-year old male patient referred to the Clinic of Dentistry of Vojvodina in Novi Sad, because of teeth loss in the right lateral region of the lower jaw. Clinical examination revealed a pronounced resorption of the residual ridge of the lower jaw in the aforementioned region, both horizontal and vertical. After clinical examination, the patient was referred for 3D cone beam (CBCT scan that enables visualization of bony structures and accurate measurement of dimensions of the residual alveolar ridge. Considering the large extent of bone resorption, the required ridge augmentation was more than 3 mm in height and 2 mm in width along the length of some 2 cm, thus the use of granular material was excluded. After consulting prosthodontists and engineers from the Faculty of Technical Sciences in Novi Sad we decided to fabricate an individual (custom bovine-derived bone graft designed according to the obtained 3D CBCT scan. Conclusion. Application of 3D CBCT images, computer-aided systems and software in manufacturing custom bone grafts represents the most recent method of guided bone regeneration. This method substantially reduces time of recovery and carries minimum risk of postoperative complications, yet the results fully satisfy the requirements of both the patient and the therapist.

  12. Application of modern computer-aided technologies in the production of individual bone graft: A case report.

    Science.gov (United States)

    Mirković, Sinisa; Budak, Igor; Puskar, Tatjana; Tadić, Ana; Sokac, Mario; Santosi, Zeljko; Djurdjević-Mirković, Tatjana

    2015-12-01

    An autologous bone (bone derived from the patient himself) is considered to be a "golden standard" in the treatment of bone defects and partial atrophic alveolar ridge. However, large defects and bone losses are difficult to restore in this manner, because extraction of large amounts of autologous tissue can cause donor-site problems. Alternatively, data from computed tomographic (CT) scan can be used to shape a precise 3D homologous bone block using a computer-aided design-computer-aided manufacturing (CAD-CAM) system. A 63-year old male patient referred to the Clinic of Dentistry of Vojvodina in Novi Sad, because of teeth loss in the right lateral region of the lower jaw. Clinical examination revealed a pronounced resorption of the residual ridge of the lower jaw in the aforementioned region, both horizontal and vertical. After clinical examination, the patient was referred for 3D cone beam (CB)CT scan that enables visualization of bony structures and accurate measurement of dimensions of the residual alveolar ridge. Considering the large extent of bone resorption, the required ridge augmentation was more than 3 mm in height and 2 mm in width along the length of some 2 cm, thus the use of granular material was excluded. After consulting prosthodontists and engineers from the Faculty of Technical Sciences in Novi Sad we decided to fabricate an individual (custom) bovine-derived bone graft designed according to the obtained-3D CBCT scan. Application of 3D CBCT images, computer-aided systems and software in manufacturing custom bone grafts represents the most recent method of guided bone regeneration. This method substantially reduces time of recovery and carries minimum risk of postoperative complications, yet the results fully satisfy the requirements of both the patient and the therapist.

  13. NEXUS/NASCAD- NASA ENGINEERING EXTENDIBLE UNIFIED SOFTWARE SYSTEM WITH NASA COMPUTER AIDED DESIGN

    Science.gov (United States)

    Purves, L. R.

    1994-01-01

    NEXUS, the NASA Engineering Extendible Unified Software system, is a research set of computer programs designed to support the full sequence of activities encountered in NASA engineering projects. This sequence spans preliminary design, design analysis, detailed design, manufacturing, assembly, and testing. NEXUS primarily addresses the process of prototype engineering, the task of getting a single or small number of copies of a product to work. Prototype engineering is a critical element of large scale industrial production. The time and cost needed to introduce a new product are heavily dependent on two factors: 1) how efficiently required product prototypes can be developed, and 2) how efficiently required production facilities, also a prototype engineering development, can be completed. NEXUS extendibility and unification are achieved by organizing the system as an arbitrarily large set of computer programs accessed in a common manner through a standard user interface. The NEXUS interface is a multipurpose interactive graphics interface called NASCAD (NASA Computer Aided Design). NASCAD can be used to build and display two and three-dimensional geometries, to annotate models with dimension lines, text strings, etc., and to store and retrieve design related information such as names, masses, and power requirements of components used in the design. From the user's standpoint, NASCAD allows the construction, viewing, modification, and other processing of data structures that represent the design. Four basic types of data structures are supported by NASCAD: 1) three-dimensional geometric models of the object being designed, 2) alphanumeric arrays to hold data ranging from numeric scalars to multidimensional arrays of numbers or characters, 3) tabular data sets that provide a relational data base capability, and 4) procedure definitions to combine groups of system commands or other user procedures to create more powerful functions. NASCAD has extensive abilities to

  14. NEXUS/NASCAD- NASA ENGINEERING EXTENDIBLE UNIFIED SOFTWARE SYSTEM WITH NASA COMPUTER AIDED DESIGN

    Science.gov (United States)

    Purves, L. R.

    1994-01-01

    NEXUS, the NASA Engineering Extendible Unified Software system, is a research set of computer programs designed to support the full sequence of activities encountered in NASA engineering projects. This sequence spans preliminary design, design analysis, detailed design, manufacturing, assembly, and testing. NEXUS primarily addresses the process of prototype engineering, the task of getting a single or small number of copies of a product to work. Prototype engineering is a critical element of large scale industrial production. The time and cost needed to introduce a new product are heavily dependent on two factors: 1) how efficiently required product prototypes can be developed, and 2) how efficiently required production facilities, also a prototype engineering development, can be completed. NEXUS extendibility and unification are achieved by organizing the system as an arbitrarily large set of computer programs accessed in a common manner through a standard user interface. The NEXUS interface is a multipurpose interactive graphics interface called NASCAD (NASA Computer Aided Design). NASCAD can be used to build and display two and three-dimensional geometries, to annotate models with dimension lines, text strings, etc., and to store and retrieve design related information such as names, masses, and power requirements of components used in the design. From the user's standpoint, NASCAD allows the construction, viewing, modification, and other processing of data structures that represent the design. Four basic types of data structures are supported by NASCAD: 1) three-dimensional geometric models of the object being designed, 2) alphanumeric arrays to hold data ranging from numeric scalars to multidimensional arrays of numbers or characters, 3) tabular data sets that provide a relational data base capability, and 4) procedure definitions to combine groups of system commands or other user procedures to create more powerful functions. NASCAD has extensive abilities to

  15. Lotus-on-chip: computer-aided design and 3D direct laser writing of bioinspired surfaces for controlling the wettability of materials and devices.

    Science.gov (United States)

    Diaz Lantada, Andres; Hengsbach, Stefan; Bade, Klaus

    2017-07-28

    In this study we present the combination of a math-based design strategy with direct laser writing as high-precision technology for promoting solid free-form fabrication of multi-scale biomimetic surfaces. Results show a remarkable control of surface topography and wettability properties. Different examples of surfaces inspired on the lotus leaf, which to our knowledge are obtained for the first time following a computer-aided design with this degree of precision, are presented. Design and manufacturing strategies towards microfluidic systems whose fluid driving capabilities are obtained just by promoting a design-controlled wettability of their surfaces, are also discussed and illustrated by means of conceptual proofs. According to our experience, the synergies between the presented computer-aided design strategy and the capabilities of direct laser writing, supported by innovative writing strategies to promote final size while maintaining high precision, constitute a relevant step forward towards materials and devices with design-controlled multi-scale and micro-structured surfaces for advanced functionalities. To our knowledge, the surface geometry of the lotus leaf, which has relevant industrial applications thanks to its hydrophobic and self-cleaning behavior, has not yet been adequately modeled and manufactured in an additive way with the degree of precision that we present here. © 2017 IOP Publishing Ltd.

  16. A Pilot Computer-Aided Design and Manufacturing Curriculum that Promotes Engineering

    Science.gov (United States)

    2002-01-01

    Elizabeth City State University (ECSU) is located in a community that is mostly rural in nature. The area is economically deprived when compared to the rest of the state. Many businesses lack the computerized equipment and skills needed to propel upward in today's technologically advanced society. This project will close the ever-widening gap between advantaged and disadvantaged workers as well as increase their participation with industry, NASA and/or other governmental agencies. Everyone recognizes computer technology as the catalyst for advances in design, prototyping, and manufacturing or the art of machining. Unprecedented quality control and cost-efficiency improvements are recognized through the use of computer technology. This technology has changed the manufacturing industry with advanced high-tech capabilities needed by NASA. With the ever-widening digital divide, we must continue to provide computer technology to those who are socio-economically disadvantaged.

  17. An Automated Tool for Developing Experimental Designs: The Computer-Aided Design Reference for Experiments (CADRE)

    Science.gov (United States)

    2009-01-01

    hard copy tables in the covers of textbooks (Siegel and Castellan , 1988). With the advent of hyperlink technology that can embed such information...topic. Siegel (Siegel and Castellan , 1988) provides a detailed discussion of all of these techniques, and their formulae and notation are used...described in this reference material are often used in human factors and ergonomics research. Once again, Siegel and Castellan (1988) 5 provide a

  18. Computer aided dispatch - a discussion of how communications technology is used to improve customer service

    Energy Technology Data Exchange (ETDEWEB)

    Swailes, J.B. [Canadian Western Natural Gas Ltd. , Calgary, AB (Canada)

    1995-11-01

    The use of Computer Aided Dispatch (CAD) for information exchange between the corporate information network and the field personnel of the CU Gas Group was described. CAD was described as two interconnected systems; a large mainframe software system which interfaces with the radio transmission system as well as the Customer Information System (CIS), and a mini computer system which consists of mobile data terminals (MDTs), the radio hardware and the software necessary to communicate with the MDTs. Further details were given on the functionality of both the mainframe, as well as the mini computer system. Some of the functions performed by the CAD include call taking, employee calendar, work assignment, filling work, dispatching, reporting, correcting errors, providing order status information, fleet monitoring, appointments, and many others. The implementation process, the challenges faced by the communications team and their interactions with the organization was also described. The most important benefit was claimed to be improved customer service. The significance of that to corporate strategy was stressed.

  19. Database Design Methodology and Database Management System for Computer-Aided Structural Design Optimization.

    Science.gov (United States)

    1984-12-01

    1983). Several researchers Lillehagen and Dokkar (1982), Grabowski, Eigener and Ranch (1978), and Eberlein and Wedekind (1982) have worked on database...Proceedings of International Federation of Information Processing. pp. 335-366. Eberlein, W. and Wedekind , H., 1982, "A Methodology for Embedding Design

  20. Modification to the Monte Carlo N-Particle (MCNP) Visual Editor (MCNPVised) to Read in Computer Aided Design (CAD) Files

    Energy Technology Data Exchange (ETDEWEB)

    Randolph Schwarz; Leland L. Carter; Alysia Schwarz

    2005-08-23

    Monte Carlo N-Particle Transport Code (MCNP) is the code of choice for doing complex neutron/photon/electron transport calculations for the nuclear industry and research institutions. The Visual Editor for Monte Carlo N-Particle is internationally recognized as the best code for visually creating and graphically displaying input files for MCNP. The work performed in this grant was used to enhance the capabilities of the MCNP Visual Editor to allow it to read in both 2D and 3D Computer Aided Design (CAD) files, allowing the user to electronically generate a valid MCNP input geometry.

  1. A Short Review of Chemical Reaction Database Systems, Computer-Aided Synthesis Design, Reaction Prediction and Synthetic Feasibility.

    Science.gov (United States)

    Warr, Wendy A

    2014-06-01

    This article is the text for a pedagogical lecture to be given at the Strasbourg Summer School in Chemoinformatics in June 2104. It covers a very wide range of reaction topics including structure and reaction representation, reaction centers, atom-to-atom mapping, reaction retrieval systems, computer-aided synthesis design, retrosynthesis, reaction prediction and synthetic feasibility. In the time available the coverage of each topic can only be cursory; the main usefulness of this article to the research community is the extensive bibliography.

  2. Modification to the Monte Carlo N-Particle (MCNP) Visual Editor (MCNPVised) to Read in Computer Aided Design (CAD) Files

    Energy Technology Data Exchange (ETDEWEB)

    Randolph Schwarz; Leland L. Carter; Alysia Schwarz

    2005-08-23

    Monte Carlo N-Particle Transport Code (MCNP) is the code of choice for doing complex neutron/photon/electron transport calculations for the nuclear industry and research institutions. The Visual Editor for Monte Carlo N-Particle is internationally recognized as the best code for visually creating and graphically displaying input files for MCNP. The work performed in this grant was used to enhance the capabilities of the MCNP Visual Editor to allow it to read in both 2D and 3D Computer Aided Design (CAD) files, allowing the user to electronically generate a valid MCNP input geometry.

  3. Research progress of zirconia all-ceramic restoration by Computer aided design and computer aided manufacture%CAD/CAM氧化锆全瓷修复的研究进展

    Institute of Scientific and Technical Information of China (English)

    商丽娟; 徐永军; 吴岩

    2014-01-01

    CAD/CAM氧化锆全瓷冠桥因其制作便捷快速、美观,稳定性和生物相容性好等优点,在口腔修复领域中有良好的应用前景。本文就CAD/CAM氧化锆全瓷修复的研究现状做一综述。%Zirconia all-ceramic crown and bridge by computer aided design ( CAD) and computer aided manufacture ( CAM) had good prospects in the field of prosthodontics, and they had the advantages of rapid and convenient production process, and good aesthetic result, stability and biocompatibility. In this review, the progress of studies and clinical applications on zirconia all-ceramic crown and bridge by CAD/CAM was introduced.

  4. Planificación tridimensional y utilización de férulas Computer Aided Design/Computed Aided Manufacturing en cirugía ortognática

    OpenAIRE

    Samir Aboul-Hosn Centenero

    2014-01-01

    El presente trabajo se centra en explicar las ventajas que aporta la planificación tridimensional (3D) y la confección de férulas quirúrgicas Computer Aided Design/Computed Aided Manufacturing (CAD/CAM) en cirugía ortognática. La digitalización del entorno laboral es una realidad imparable en nuestra sociedad y, en nuestra especialidad, nos proporciona ventajas desde un punto de vista logístico, de precisión diagnóstica y en la confección de férulas quirúrgicas. Las tradicionales férulas quir...

  5. Computer-aided Framework for Synthesis, Design and Retrofit of Wastewater Treatment Plants

    DEFF Research Database (Denmark)

    Bozkurt, Hande

    plant (WWTP) design is a formidable challenge. One of the key steps involved is the process synthesis - defined as the selection of treatment processes as a combination of unit operations and processes to create the process flow diagram.As a consequence of the emerging technological developments...

  6. Computer-aided and predictive models for design of controlled release of pesticides

    DEFF Research Database (Denmark)

    Suné, Nuria Muro; Gani, Rafiqul

    2004-01-01

    In the field of pesticide controlled release technology, a computer based model that can predict the delivery of the Active Ingredient (AI) from fabricated units is important for purposes of product design and marketing. A model for the release of an M from a microcapsule device is presented...

  7. Effectiveness of using CADD (Computer-Aided Design Drafting) to learn engineering design graphics

    Energy Technology Data Exchange (ETDEWEB)

    Bertoline, G.R.

    1987-01-01

    One commercial CADD software and one educational CADD software was compared to the use of traditional tools. Engineering-graphics students were divided into three groups. The control group used traditional tools for all their drawings. One experimental group used a commercial CADD software to supplement hand tools and one group used an educational CADD software to supplement traditional tools. These groups were then post-tested using a standardized drafting test. The main findings were: (1) There was no significant difference in the learning of engineering graphics as measured by the post-tests. Supplementing traditional tools with CADD is effective for teaching engineering design graphics. (2) Using CADD for detail drawings such as simple orthographic drawings, sections, and dimensions could be produced in approximately the same amount of time as using traditional tools. (3) It was found that the amount of time needed to solve descriptive geometry problems using CADD was prohibitive. The amount of time to solve some descriptive geometry problems was two or three times greater using CADD versus traditional tools.

  8. Computer aided control engineering

    DEFF Research Database (Denmark)

    Szymkat, Maciej; Ravn, Ole

    1997-01-01

    levels.The major conclusions of the paper are related with identifying the factors affecting the software tool integration in a way needed to facilitate design "inter-phase" communication. These are: standard application interfaces, dynamic data exchange mechanisms, code generation techniques and general......Current developments in the field of Computer Aided Control Engineering (CACE) have a visible impact on the design methodologies and the structure of the software tools supporting them. Today control engineers has at their disposal libraries, packages or programming environments that may...

  9. Dynamic light as a transformational tool in computer-aided design

    DEFF Research Database (Denmark)

    Hansen, Ellen Kathrine; Mullins, Michael Finbarr; Triantafyllidis, Georgios

    2016-01-01

    Architecture and lighting technology has undergone a revolution in recent years, as new sensor technologies and computational skills enable ‘intelligent materials’, interactive control of light, energy-saving measures and new LED technology to be applied in the built environment, which can...... technical/scientific, social scientific and art/humanities backgrounds. The model is applied to a pedagogical curriculum in the context of multi-level learning competencies. Case: The Absalon Church The intention of the project is to transform a city church building, situated in an older, dense, housing...... materials, communicating the design idea with different light settings. The time aspect was essential in this context, and the video therefore an important tool. While luminance levels can be predicted and measured relatively easily, several of the success criteria for the project revolved around achieving...

  10. Computer-aided design and modeling of workstations and radiology reading rooms for the new millennium.

    Science.gov (United States)

    Ratib, O; Valentino, D J; McCoy, M J; Balbona, J A; Amato, C L; Boots, K

    2000-01-01

    Three-dimensional (3D) computer modeling, simulation, and rendering techniques were used to redesign the diagnostic workstations and radiology reading rooms for a proposed hospital with particular attention given to lighting conditions, noise reduction, and optimal use of limited workspace. The results were presented to a panel of multidisciplinary experts and iteratively improved and redesigned with the development or addition of new design criteria or requirements. These 3D techniques allowed faster, more efficient design and presentation of multiple options than is possible with traditional two-dimensional drawings, thereby expediting decision making and resulting in significant savings. The current workstation designs can easily be developed and implemented with available technology at a reasonable cost. They can also accommodate anticipated advances in computer and display technology as well as new imaging paradigms (eg, changes in keyboard and control ergonomics such as adjustable virtual keys on touch-sensitive screens, digital drawing tablets for annotations and controls, direct film digitizing, personal identification devices, offline media readers such as compact disks and digital videodisks, and speech recognition and voice activation). Use of 3D techniques in designing other parts of the radiology department (eg, examination rooms, technologists' areas, physicians' offices) could greatly improve and facilitate the design and implementation of complex settings in these work areas.

  11. Sensitivity analysis of Computer-aided molecular design problem for the development of novel working fluids for power cycles

    DEFF Research Database (Denmark)

    Frutiger, Jerome; Abildskov, Jens; Sin, Gürkan

    allows the ranking ofsignificance of properties and also the identification of a set of properties which are relevant for the design of a workingfluids.In this study the CAMD problem for the development of novel working fluids for organic Rankine cycles (ORC) isformulated as a mathematical optimization...... technical tool to convert this waste heat into usable energy. So far the low-temperature heat cannot be utilized efficiently for electricity generation.In order to optimize the heat transfer process and the power generation, the influence of the working fluid, the cycledesigns and the operating conditions...... is vital. Multi-criteria database search and Computer Aided Molecular Design(CAMD) can be applied to generate, test and evaluate promising pure component/mixture candidate as process fluids to help optimize cycle design and performance. The problem formulation for the development of novel working fluids...

  12. COMPUTER-AIDED ENVIRONMENTAL RISK ASSESSMENT OF POTATO CULTIVATION TECHNOLOGY USING OPENLCA SOFTWARE

    Directory of Open Access Journals (Sweden)

    Jerzy Ryszard Grudziński

    2016-11-01

    Full Text Available The article discusses the environmental impact of the tillage processes of potato production. The analysis was performed using a simplified LCA ( Life Cycle Assessment software. Depending on the purpose and the level of detail of the process analysis, the LCA technique of environmental management may require computer assistance. Even then, carrying it out is very complex, long and costly. The aim of the study was to explore the possibility of the use of open source software for a simplified life-cycle analysis of potato with LCA method. There was selected OpenLCA – GreenDelta TC GmbH, v.1.3.1 software. The diagrams of unit process streams and energy inputs incurred on the individual processes of cultivation were designed based on literature. There were compared environmental hazards of the two systems of potato cultivation: with using the plough and the simplified one in terms of atmospheric pollution with chemicals emitted by the engines of agricultural tractors in the course of the subsequent agricultural procedures. The study results confirmed the suitability of the software for the initial evaluation (screening of environmental hazards using LCA method. The software is compatible with both the open source databases and commercial databases. Environmental impacts of cultivation technologies are presented in a form of a graphic illustration of pollution emissions. Also, the problems hindering the use of the software are indicated.

  13. Computer-aided design of peptide near infrared fluorescent probe for tumor diagnosis

    Science.gov (United States)

    Zhang, Congying; Gu, Yueqing

    2014-09-01

    Integrin αvβ3 receptors are expressed on activated endothelial cells during neovascularization to maintain tumor growth, so they become hot research tagets in cancer diagnosis. Peptides possess several attractive features when compared to protein and small molecule, such as small size and high structural compatibility with target proteins. Efficient design of high-affinity peptide ligands to Integrin αvβ3 receptors has been an important problem. Designed peptides in silico provide a valuable and high-selectivity peptide, meanwhile decrease the time of drug screening. In this study, we design peptide which can bind with integrin αvβ3 via computer, and then synthesis near infrared fluorescent probe. The characterization of this near infrared fluorescent probe was detected by UV. To investigate the tumor cell targeting of this probe, it was labeled with visible fluorescent dye Rhodamine B (RhB) for microscopy. To evaluate the targeting capability of this near infrared fluorescent probe, mice bearing integrin αvβ3 positive tumor xenografts were used. In vitro cellular experiments indicated that this probe have a clear binding affinity to αvβ3-positive tumor cells. In vivo experiments confirmed the receptor binding specificity of this probe. The peptide of computational design can bind with integrin αvβ3. Combined peptide near-infrared fluorescent probe with imaging technology use for clinical and tumor diagnosis have a greater development in future.

  14. Virtual environment and computer-aided technologies used for system prototyping and requirements development

    Science.gov (United States)

    Logan, Cory; Maida, James; Goldsby, Michael; Clark, Jim; Wu, Liew; Prenger, Henk

    1993-01-01

    The Space Station Freedom (SSF) Data Management System (DMS) consists of distributed hardware and software which monitor and control the many onboard systems. Virtual environment and off-the-shelf computer technologies can be used at critical points in project development to aid in objectives and requirements development. Geometric models (images) coupled with off-the-shelf hardware and software technologies were used in The Space Station Mockup and Trainer Facility (SSMTF) Crew Operational Assessment Project. Rapid prototyping is shown to be a valuable tool for operational procedure and system hardware and software requirements development. The project objectives, hardware and software technologies used, data gained, current activities, future development and training objectives shall be discussed. The importance of defining prototyping objectives and staying focused while maintaining schedules are discussed along with project pitfalls.

  15. Computer-Aided Argument Mapping in an EFL Setting: Does Technology Precede Traditional Paper and Pencil Approach in Developing Critical Thinking?

    Science.gov (United States)

    Eftekhari, Maryam; Sotoudehnama, Elaheh; Marandi, S. Susan

    2016-01-01

    Developing higher-order critical thinking skills as one of the central objectives of education has been recently facilitated via software packages. Whereas one such technology as computer-aided argument mapping is reported to enhance levels of critical thinking (van Gelder 2001), its application as a pedagogical tool in English as a Foreign…

  16. Computer-Aided Argument Mapping in an EFL Setting: Does Technology Precede Traditional Paper and Pencil Approach in Developing Critical Thinking?

    Science.gov (United States)

    Eftekhari, Maryam; Sotoudehnama, Elaheh; Marandi, S. Susan

    2016-01-01

    Developing higher-order critical thinking skills as one of the central objectives of education has been recently facilitated via software packages. Whereas one such technology as computer-aided argument mapping is reported to enhance levels of critical thinking (van Gelder 2001), its application as a pedagogical tool in English as a Foreign…

  17. Graphical User Interface (GUI) Design for Ballistic Research Laboratory-Computer-Aided Design’s (BRL-CAD’s) Geometry Difference (GDiff) Tool

    Science.gov (United States)

    2015-04-01

    Graphical User Interface ( GUI ) Design for Ballistic Research Laboratory–Computer-Aided Design’s (BRL–CAD’s) Geometry Difference (GDiff) Tool...to the originator. Army Research Laboratory Aberdeen Proving Ground, MD 21005 ARL-CR-0756 April 2015 Graphical User Interface ( GUI ...2015 2. REPORT TYPE Contractor Report 3. DATES COVERED (From - To) 06/2014–08/2014 4. TITLE AND SUBTITLE Graphical User Interface ( GUI ) Design for

  18. 计算机辅助工业设计课程改革探索%Exploration on Course Innovation of Computer Aided Industry Design

    Institute of Scientific and Technical Information of China (English)

    梅云

    2012-01-01

    针对我国的计算机辅助工业设计课程改革的问题,本文进行了初步探索,分别从计算机辅助工业设计专业课程重难点问题及解决方法和课程考核方式改革效果等进行了分析,希望对于该课程教学质量的提高起到一定的作用。%For the problem of computer aided industry design course,this paper carries out some new ways.It analyzes the difficulty and key points of computer aided industry design course,and then analyzes the effective of computer aided industry design course examination.It can promote the course teaching performance.

  19. Computer aided learning in teaching environment protection in energy technology; Energiateknisen ympaeristoensuojelun tietokoneavusteinen opetus

    Energy Technology Data Exchange (ETDEWEB)

    Lehtinen, M.

    1994-12-31

    CAL-software has been planned and produced and its suitability for teaching has been studied. The aim of the CAL-software is to give basic knowledge of Energy Technical Environment Conservation. It was made in the Windows environment with ToolBook and it runs on PCs. The aims of the program were clearness of presentation, ease of use and reliability. The content was taken from the Course Introduction to Environmental Protection in Energy Technology. The Material has been divided into eight chapters and revision questions. Each chapter works also as an independent part. The program differs from a book in that there are models, tasks, demonstrations and revision questions. Students can test their own learning and conclude by their results which fields they should revise. The Program was tested on a course called an Individual Assignment in Energy Engineering by nine students, who simultaneously enrolled on the course Introduction to Environmental Protection in Energy Technology. At first students used certain parts of the program with great care and then discussions were held about its strengths and weaknesses, and improvements were considered. When the whole program had been tested all students wrote essays, which were used to develop the program. Students feedback on the program was mostly positive

  20. Using GREENSCOPE Indicators for Sustainable Computer-Aided Process Evaluation and Design

    Science.gov (United States)

    Manufacturing sustainability can be increased by educating those who design, construct, and operate facilities, and by using appropriate tools for process evaluation and design. The U.S. Environmental Protection Agency's GREENSCOPE methodology and tool, for evaluation and design ...

  1. Integrated Computer-aided Framework for Sustainable Chemical Product Design and Evaluation

    DEFF Research Database (Denmark)

    Kalakul, Sawitree; Cignitti, Stefano; Zhang, Lei

    2016-01-01

    This work proposes an integrated model-based framework for chemical product design and evaluation based on which the software, VPPD-Lab (The Virtual Product-Process Design Laboratory) has been developed. The framework allows the following options: (1) design a product using design templates...... of the templates for three case studies: (i) the design of a refrigeration cycle, (ii) a mixture/blend design problem involving lubricant design and (iii) a tailor-made product design of jet-fuels (blended chemical products)....

  2. Comparisons of Wilson-Fowler and Parametric Cubic Splines with the Curve-Fitting Algorithms of Several Computer-Aided Design Systems

    Energy Technology Data Exchange (ETDEWEB)

    Birchler, W.D.; Schilling, S.A.

    2001-02-01

    The purpose of this report is to demonstrate that modern computer-aided design (CAD), computer-aided manufacturing (CAM), and computer-aided engineering (CAE) systems can be used in the Department of Energy (DOE) Nuclear Weapons Complex (NWC) to design new and remodel old products, fabricate old and new parts, and reproduce legacy data within the inspection uncertainty limits. In this study, two two-dimensional splines are compared with several modern CAD curve-fitting modeling algorithms. The first curve-fitting algorithm is called the Wilson-Fowler Spline (WFS), and the second is called a parametric cubic spline (PCS). Modern CAD systems usually utilize either parametric cubic and/or B-splines.

  3. Upon the Modeling and the Optimization of the Debiting Process through Computer Aided Non-Conventional Technologies

    Directory of Open Access Journals (Sweden)

    Tiberiu Marius Karnyanszky

    2009-01-01

    Full Text Available he debiting process of the remarkable properties materials can be managed through unconventional technologies as the complex electrical erosion. This paper presents the mathematical modeling and simulation of a particular processing to establish the shortest cutting time and the better surface quality based on the best combination of input parameters. This paper presents the modeling of the previous experimental results to obtain a mathematical dependence of the output parameters (processing time, surface quality on the input parameters (voltage or current. All the experimental data are memorized on a database and for each particular debiting process a new dependence is built. The previous results database is built using personal experiments and results presented in references. These results were obtained using a research scheduler and a computer-based application organizes these results into a database separated on different mechanical processes, work conditions, materials, devices. All the experiments applied in the Romanian laboratories or practical applications of the nonconventional technological processes in the factories were based on the particular conditions of one activity. This papers presents the technical implementation of a computer-aided solution that keeps all previous experimental data, optimizes the processing conditions and eventual manage the driving gear. The flow-chart we present in this paper offers a solution for practitioners to reduce the electrical consumption while a technological processing of special materials is necessary. The computer program and the database can be easily adapted to any technological processes (conventional or not. No general available mathematical formulas for the dependency of the output parameters on the input ones are yet presented. The software we developed uses interpolation to determine the best polynomial or exponential equation and offers the combination of input values to minimize the

  4. Computer Aided Product Service Systems Design: Service CAD and Its integration with Life Cycle Simulation

    NARCIS (Netherlands)

    Komoto, H.

    2009-01-01

    Integration of product design into service design, or vice versa, is considered to bring more efficient and effective value addition. Besides EcoDesign tools and methods, a methodology to design such an integration of products and services from a systemic perspective, or product-service systems (PSS

  5. Computer Aided Product Service Systems Design: Service CAD and Its integration with Life Cycle Simulation

    NARCIS (Netherlands)

    Komoto, H.

    2009-01-01

    Integration of product design into service design, or vice versa, is considered to bring more efficient and effective value addition. Besides EcoDesign tools and methods, a methodology to design such an integration of products and services from a systemic perspective, or product-service systems

  6. Using Computer-Aided Design Software and 3D Printers to Improve Spatial Visualization

    Science.gov (United States)

    Katsio-Loudis, Petros; Jones, Millie

    2015-01-01

    Many articles have been published on the use of 3D printing technology. From prefabricated homes and outdoor structures to human organs, 3D printing technology has found a niche in many fields, but especially education. With the introduction of AutoCAD technical drawing programs and now 3D printing, learners can use 3D printed models to develop…

  7. Using Computer-Aided Design Software and 3D Printers to Improve Spatial Visualization

    Science.gov (United States)

    Katsio-Loudis, Petros; Jones, Millie

    2015-01-01

    Many articles have been published on the use of 3D printing technology. From prefabricated homes and outdoor structures to human organs, 3D printing technology has found a niche in many fields, but especially education. With the introduction of AutoCAD technical drawing programs and now 3D printing, learners can use 3D printed models to develop…

  8. Technical issues associated with innovative environmental technology: FTIR computer aided tomography

    Energy Technology Data Exchange (ETDEWEB)

    Todd, L.A. [Univ. of North Carolina, Chapel Hill, NC (United States). Dept. of Environmental Sciences and Engineering

    1995-12-31

    This research reports on a new innovation in chemical measurement technology that combines Open-path Fourier Transform Infrared (OP-FTIR) spectroscopy with computed tomography to create two-dimensional maps of air contaminants that are both spatially and temporally resolved. This method has been evaluated with numerical studies that tested different iterative reconstruction algorithms and OP-FTIR configurations. The success of this system for characterizing the flow of contaminants in air, exposure assessment, emission monitoring and leak detection, was closely linked to the choice of reconstruction algorithm and configuration. A systematic method was developed to evaluate these parameters using static and time series test maps under ideal and non-ideal sampling conditions. Concentration map quality was evaluated using qualitative and quantitative criteria. Map reconstruction quality using different algorithms configurations was found to be intimately related to the complexity of the test maps. The results of this research underscored the need to thoroughly test the system through numerical studies prior to field implementation; a wide variety of concentration maps, relevant to the application, should be tested under both ideal and non-ideal sampling conditions.

  9. Computer-aided design of digital radio devices with frequency representation of information

    OpenAIRE

    Kychak, Vasyl; Kychak, Volodymyr

    2012-01-01

    This paper presents a system of automated design of digital radio devices with frequency representation of information, which can significantly simplify the design process of digital devices with large number of input signals.

  10. A computer-aided approach for achieving sustainable process design by process intensification

    DEFF Research Database (Denmark)

    Anantasarn, Nateetorn; Suriyapraphadilok, Uthaiporn; Babi, Deenesh Kavi

    2017-01-01

    to generate flowsheet alternatives that satisfy the design targets thereby, minimizing and/or eliminating the process hot-spots. The application of the framework is highlighted through the production of para-xylene via toluene methylation where more sustainable flowsheet alternatives that consist of hybrid......Process intensification can be applied to achieve sustainable process design. In this paper, a systematic, 3-stage synthesis-intensification framework is applied to achieve more sustainable design. In stage 1, the synthesis stage, an objective function and design constraints are defined and a base...... case is synthesized. In stage 2, the design and analysis stage, the base case is analyzed using economic and environmental analyses to identify process hot-spots that are translated into design targets. In stage 3, the innovation design stage, phenomena-based process intensification is performed...

  11. COMPUTER AIDED DESIGN OF THE STRIP LAYOUT IN PROGRESSIVE CUTTING DIE

    Directory of Open Access Journals (Sweden)

    Faruk MENDİ

    2000-02-01

    Full Text Available Progressive cutting dies have a very important position on the series manufacture of the sheet metals by the method of no-turnings reproduction system. By using classical methods, the design of the dies and the choosing of the suitable die parts are generally time consuming and money spending for designer. In this study, we development a program based on 1 MB study in QBASIC program which can design strip layout. According to the data base, in addition to strip layout design, force analysis, force capacity of the press dies, gravity force center can be found. By making the design of not standard die parts, you can also choose the standard die parts. With this computer program for die design, you can get much more sensitive, enough flexible and fast results.

  12. Computer Aided Design of The Cooling System for Plastic Injection Molds

    Directory of Open Access Journals (Sweden)

    Hakan GÜRÜN

    2009-02-01

    Full Text Available The design of plastic injection molds and their cooling systems affect both the dimension, the shape, the quality of a plastic part and the cycle time of process and the cost of mold. In this study, the solid model design of a plastic injection mold and the design of cooling sysytem were possibly carried out without the designer interaction. Developed program permited the use of three types of the cooling system and the different cavity orientations and the multible plastic part placement into the mold cores. The program which was developed by using Visual LISP language and the VBA (Visual BASIC for Application modules, was applicated in the AutoCAD software domain. Trial studies were presented that the solid model design of plastic injection molds and the cooling systems increased the reliability, the flexibility and the speed of the design.

  13. Teaching Sustainable Process Design Using 12 Systematic Computer-Aided Tasks

    DEFF Research Database (Denmark)

    Babi, Deenesh K.

    2015-01-01

    (tasks 4-7) and then sizing, costing and economic analysis of the designed process (tasks 8-9). This produces a base case design. In tasks 10-12, the student explores opportunities for heat and/or mass integration, followed by a sustainability analysis, in order to evaluate the base case design and set......In this paper a task-based approach for teaching (sustainable) process design to students pursuing a degree in chemical and biochemical engineering is presented. In tasks 1-3 the student makes design decisions for product and process selection followed by simple and rigorous model simulations...... targets for further improvement. Finally, a process optimization problem is formulated and solved to obtain the more sustainable process design. The 12 tasks are explained in terms of input and output of each task and examples of application of this approach in an MSclevel course are reported....

  14. Belt Drive with Computer Aided Design%带传动的计算机辅助设计

    Institute of Scientific and Technical Information of China (English)

    杨桦; 张才千

    2014-01-01

    In view of traditional belt drive design problems brought about due to manual design by technical staff⋛and work process being complex⋛computer aided design is carried out and realized⋛which improves work efficiency greatly.The practical application shows that this system can meet the working requirements of belt drive design⋛solve the problems of belt driving design and can be widely applied in the future.%针对传统带传动设计主要依靠技术人员进行手工设计,工作过程计算复杂、繁琐的问题,进行带传动计算机辅助设计的研究和实现,大大提高了工作效率。实际应用表明,该系统能够满足带传动设计的工作要求,解决了带传动设计工作中存在的问题,具有极为广泛的推广应用前景。

  15. A Multi-Step and Multi-Level Approach for Computer Aided Molecular Design

    DEFF Research Database (Denmark)

    Harper, Peter Mathias; Gani, Rafiqul

    2001-01-01

    . The problem formulation step incorporates a knowledge base for the identification and setup of the design criteria. Candidate compounds are identified using a multi-level generate and test CAMD solution algorithm capable of designing molecules having a high level of molecular detail. A post solution step...

  16. Formal computer-aided product family architecture design for mass customization

    DEFF Research Database (Denmark)

    Bonev, Martin; Hvam, Lars; Clarkson, John

    2015-01-01

    are informal, providing limited support for domain experts to communicate, synthesize and document architectures effectively. In single product design explicit visual models such as design structure matrices and node-link diagrams have been used in combination with structural analysis methods to overcome...

  17. Methodology of Computer-Aided Design of Variable Guide Vanes of Aircraft Engines

    Science.gov (United States)

    Falaleev, Sergei V.; Melentjev, Vladimir S.; Gvozdev, Alexander S.

    2016-01-01

    The paper presents a methodology which helps to avoid a great amount of costly experimental research. This methodology includes thermo-gas dynamic design of an engine and its mounts, the profiling of compressor flow path and cascade design of guide vanes. Employing a method elaborated by Howell, we provide a theoretical solution to the task of…

  18. Computer-aided approach for design of tailor-made blended products

    DEFF Research Database (Denmark)

    Yunus, Nor Alafiza; Gernaey, Krist; Woodley, John

    2012-01-01

    library developed specifically for this methodology. Thirdly, a mixture/blend design algorithm is applied to obtain the mixtures/blends (gasoline blend in this case) that match the set of constraints (design targets). The result is a set of blends that match the constraints, the composition...... related to the design of blended gasoline with different types of blending agents. The objective of this study is to identify blended gasoline products that match the traditional gasoline attributes and identify suitable blending agents for gasoline....

  19. Computer-Aided Design Methods for Model-Based Nonlinear Engine Control Systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Traditional design methods for aircraft turbine engine control systems have relied on the use of linearized models and linear control theory. While these controllers...

  20. Computer aided design, analysis and experimental investigation of membrane assisted batch reaction-separation systems

    DEFF Research Database (Denmark)

    Mitkowski, Piotr Tomasz; Buchaly, Carsten; Kreis, Peter;

    2009-01-01

    Membrane assisted batch reaction operation offers an interesting option for equilibrium limited reaction systems in chemical and biochemical manufacturing by selective removal of one of the products and thereby increasing the product yield. The design of such hybrid systems need to take into acco...... and separation functionalities and to design/analyse the hybrid scheme. The generated hybrid scheme has been validated through experiments involving an esterification reaction....

  1. VPIsystems industry training program on computer-aided design of fiber optic communication systems

    Science.gov (United States)

    Richter, Andre; Chan, David K. C.

    2002-05-01

    In industry today, professional Photonic Design Automation (PDA) tools are a necessity to enable fast development cycles for the design of optical components, systems and networks. The training of industrial personnel is of great importance in facilitating the full usability of PDA tools tailored to meet these demands. As the market leader of design and planning tools for system integrators and manufacturers of optical transmission systems and components, VPIsystems offers a set of two-day training courses. Attendees are taught on the design of metro WDM networks, high speed DWDM and ultra long-haul WDM systems, analogue and digital cable access systems, EDFA and Raman amplifiers, as well as active devices and circuits. The course work compromises of: (1) lectures on physical and modeling background topics; (2) creation of typical simulation scenarios and; (3) the analysis of results. This course work is facilitated by guided, hands-on lab exercises using VPIsystems software for a variety of practical design situations. In classes of up to 15, each attendee is allocated a computer, thereby allowing for a thorough and speedy training for the individual in all of the covered topics as well as for any extra-curriculum topics to be covered. Since 1999, more than 750 people have graduated from over 60 training courses. In this paper, details of VPIsystems Industry training program will be presented.

  2. Current trends in the design of scaffolds for computer-aided tissue engineering.

    Science.gov (United States)

    Giannitelli, S M; Accoto, D; Trombetta, M; Rainer, A

    2014-02-01

    Advances introduced by additive manufacturing have significantly improved the ability to tailor scaffold architecture, enhancing the control over microstructural features. This has led to a growing interest in the development of innovative scaffold designs, as testified by the increasing amount of research activities devoted to the understanding of the correlation between topological features of scaffolds and their resulting properties, in order to find architectures capable of optimal trade-off between often conflicting requirements (such as biological and mechanical ones). The main aim of this paper is to provide a review and propose a classification of existing methodologies for scaffold design and optimization in order to address key issues and help in deciphering the complex link between design criteria and resulting scaffold properties. Copyright © 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

  3. A New Optimization Model for Computer-Aided Molecular Design Problems

    DEFF Research Database (Denmark)

    Zhang, Lei; Cignitti, Stefano; Gani, Rafiqul

    as known molecules with desired properties. The attention is in particular targeted at the design of chemical based products, such as solvents, refrigerants, active pharmaceutical ingredients, polymers, surfactants, lubricants, and more [1]. Property prediction methods are needed in molecular design...... to be determined. In this way, CAMD problems can be formulated as a Mixed Integer Linear/Non-Linear Program (MILP/MINLP). With the advent of connectivity-based prediction methods, several researchers have developed new strategies for embedding it with CAMD method. Constantinou et al. [2] proposed a systematic...

  4. The Computer Aided Integrated Design and Analysis of Oil Tank in Vehicle

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    This paper creates 3D solid model and assembly of U RJ 92-6 oil tank and analyses its strength by integrated CAD/CAE/CAM software I-D EAS. Through integrated simulation in computer, design efficiency and quality of oil tank is greatly improved. Adopting integrated CAD/CAE/CAM software to carry out integrated research to equ ipment and products, we will be able to take overall analysis in aspects of 3-D solid modeling, pre-assembly and strength, etc., to realize non-paper designi ng and parallel designing...

  5. Computer-aided polymer design using group contribution plus property models

    DEFF Research Database (Denmark)

    Satyanarayana, Kavitha Chelakara; Abildskov, Jens; Gani, Rafiqul

    2009-01-01

    . Polymer repeat unit property prediction models are required to calculate the properties of the generated repeat units. A systematic framework incorporating recently developed group contribution plus (GC(+)) models and an extended CAMD technique to include design of polymer repeat units is highlighted...... in this paper. The advantage of a GC(+) model in CAMD applications is that a very large number of polymer structures can be considered even though some of the group parameters may not be available. A number of case studies involving different polymer design problems have been solved through the developed...

  6. ''Beauty of Wholeness and Beauty of Partiality.'' New Terms Defining the Concept of Beauty in Architecture in Terms of Sustainability and Computer Aided Design

    Science.gov (United States)

    Farid, Ayman A.; Zaghloul, Weaam M.; Dewidar, Khaled M.

    2014-01-01

    The great shift in sustainability and computer aided design in the field of architecture caused a remarkable change in the architecture philosophy, new aspects of beauty and aesthetic values are being introduced, and traditional definitions for beauty cannot fully cover this aspects, which causes a gap between; new architecture works criticism and…

  7. Computer Aided Design of Ka-Band Waveguide Power Combining Architectures for Interplanetary Spacecraft

    Science.gov (United States)

    Vaden, Karl R.

    2006-01-01

    Communication systems for future NASA interplanetary spacecraft require transmitter power ranging from several hundred watts to kilowatts. Several hybrid junctions are considered as elements within a corporate combining architecture for high power Ka-band space traveling-wave tube amplifiers (TWTAs). This report presents the simulated transmission characteristics of several hybrid junctions designed for a low loss, high power waveguide based power combiner.

  8. Man-machine interactive system simplifies computer-aided circuit design

    Science.gov (United States)

    Bavuso, S. J.

    1970-01-01

    Langley interactive computerized circuit analysis capability /LICCA/ enables designer to draw electronic circuit diagrams on cathode ray tube screen. This information is submitted as input to user-selected circuit analysis program. LICCA accommodates binary logic circuits and circuits with discrete components, and monitors operator's instructions to detect errors.

  9. Computer Aided Design and Stress Analysis of Nose Landing Gear Barrel (NLGB

    Directory of Open Access Journals (Sweden)

    Sanjay Kumar Sardiwal

    2015-04-01

    Full Text Available During the conceptual design phase of aircraft the integration of undercarriage system is very important and it is often difficult to achieve on the first time. The nose wheel landing gear preferred configurations for light naval trainer aircraft. The main objective of this project is to improve the static strength criteria and fatigue life of Nose Landing Gear Barrel considered. The investigations includes preliminary design layout for Nose Landing Gear Barrel and initial sizing has been done. It has been designed and evaluated for strength criteria. A method of analysis for the design of Nose Landing Gear Barrel made up of Al-Cu alloy (BS L 168 T6511 with static loads of axial, bending and normal loads are applied. The geometric modeling of the Nose Landing Gear Barrel was carried out using CAD package CATIA V5 R19 and pre and post processing was done through MSC/PATRAN. The stresses and displacements are obtained with the application of MSC/NASTRAN finite element software.

  10. The Computer-Aided Design of a Servo System as a Multiple-Criteria Decision Problem

    OpenAIRE

    Udink ten Cate, A.J.

    1984-01-01

    The task of selecting the controller gains of a servo system is formulated as a multiple-criteria decision problem. The criteria are based on the unit step response of the system. The approach described here differs from the usual approach in that design constraints on the trajectories are included as additional criteria. Simulation runs are used to evaluate the criteria.

  11. Electrothermal System for Microwave Heating. Elements of Computer Aided Design of the Applicator

    Directory of Open Access Journals (Sweden)

    COMAN Ovidiu Gabriel

    2012-10-01

    Full Text Available Within this study was elaborated a program made with Matlab software to design an applicator of parallelepiped shape for dielectric materialsprocessing in microwave field. The program calculates and posts transmission modes, the value of the power density and of the electric field in the dielectric.

  12. Computer-Aided Design and Analysis of Digital Guidance and Control Systems.

    Science.gov (United States)

    1983-07-01

    this situation is provided by the Berkeley/ UNIX "vi" screen editor where each of the letters d, f, g and u has a different meaning if typed in lower...aided design system. Proceedings of IEEE ISCAS, Chicago, U.S.A. (April 1981). (7) Kernighan , B.W. and Plauger, P.J. Software Tools. Addison-Wesley, 1976

  13. Minimizing total costs of forest roads with computer-aided design model

    Indian Academy of Sciences (India)

    Abdullah E Akay

    2006-10-01

    Advances in personal computers (PCs) have increased interest in computer-based road-design systems to provide rapid evaluation of alternative alignments. Optimization techniques can provide road managers with a powerful tool that searches for large numbers of alternative alignments in short spans of time. A forest road optimization model, integrated with two optimization techniques, was developed to help a forest road engineer in evaluating alternative alignments in a faster and more systematic manner. The model aims at designing a path with minimum total road costs, while conforming to design specifications, environmental requirements, and driver safety. To monitor the sediment production of the alternative alignments, the average sediment delivered to a stream from a road section was estimated by using a road erosion/delivery model. The results indicated that this model has the potential to initiate a new procedure that will improve the forest road-design process by employing the advanced hardware and software capabilities of PCs and modern optimization techniques.

  14. A New Era for Cancer Target Therapies: Applying Systems Biology and Computer-Aided Drug Design to Cancer Therapies.

    Science.gov (United States)

    Wong, Yung-Hao; Chiu, Chia-Chiun; Lin, Chih-Lung; Chen, Ting-Shou; Jheng, Bo-Ren; Lee, Yu-Ching; Chen, Jeremy; Chen, Bor-Sen

    In recent years, many systems biology approaches have been used with various cancers. The materials described here can be used to build bases to discover novel cancer therapy targets in connection with computer-aided drug design (CADD). A deeper understanding of the mechanisms of cancer will provide more choices and correct strategies in the development of multiple target drug therapies, which is quite different from the traditional cancer single target therapy. Targeted therapy is one of the most powerful strategies against cancer and can also be applied to other diseases. Due to the large amount of progress in computer hardware and the theories of computational chemistry and physics, CADD has been the main strategy for developing novel drugs for cancer therapy. In contrast to traditional single target therapies, in this review we will emphasize the future direction of the field, i.e., multiple target therapies. Structure-based and ligand-based drug designs are the two main topics of CADD. The former needs both 3D protein structures and ligand structures, while the latter only needs ligand structures. Ordinarily it is estimated to take more than 14 years and 800 million dollars to develop a new drug. Many new CADD software programs and techniques have been developed in recent decades. We conclude with an example where we combined and applied systems biology and CADD to the core networks of four cancers and successfully developed a novel cocktail for drug therapy that treats multiple targets.

  15. DESIGNING OF COMPUTER AIDED AND USER INTERACTIVE CNC PART PROGRAMME FOR A MILLING MACHINE

    Directory of Open Access Journals (Sweden)

    M. Ali DÖNERTAŞ

    2005-02-01

    Full Text Available In this study, a user–interactive computer programme generating CNC part programme according to dialog method has been developed. The design of programme has been prepared like a CAM programme structure. The part programme was established by required parameters asking to the user with a specific order. Subsequently, this parameters are used to create M and G codes, and these codes are showed at a different page on the screen. In addition, these code pages can be stored with "txt" format. This program includes basic processes and the programme design has been prepared for milling machine working according to Fanuc system. The computer programme was written by using Delphi 6 programming language.

  16. Computer-aided interactive structural optimization of printed-circuit-board design

    Science.gov (United States)

    Duncan, L. B.; Holman, R. E.; Lagasse, B. K.; Sakamoto, L. W.; Sunada, W. H.

    Electronic equipment operating in severe vibration environments plays a critical role in military and aerospace hardware. A crucial element of most modularized electronic equipment is the printed circuit board (PCB). Structural failures of such boards are almost entirely the result of imposed mechanical vibration. It is desirable to incorporate structural guidelines and analysis techniques at an early stage in board development when deficiencies may easily be corrected. However, there are a number of problems connected with such an approach. A computer program has been developed to address the considered situation. The program is to reduce PCB structural analysis to a level readily understood by the average designer. Another objective of the program is to encourage use of structural analysis at an early stage of PCB design and development. Attention is given to board geometry, program organization, board response computation, and a sample problem.

  17. Model-based Computer Aided Framework for Design of Process Monitoring and Analysis Systems

    DEFF Research Database (Denmark)

    Singh, Ravendra; Gernaey, Krist; Gani, Rafiqul

    2009-01-01

    -aided framework including the methods and tools through which the design of monitoring and analysis systems for product quality control can be generated, analyzed and/or validated, has been developed. Two important supporting tools developed as part of the framework are a knowledge base and a model library...... subject to the maintenance constraints of the desired product quality. The application of the model-based framework is highlighted through a case study involving the operation of a fermentation process.......In the manufacturing industry, for example, the pharmaceutical industry, a thorough understanding of the process is necessary in addition to a properly designed monitoring and analysis system (PAT system) to consistently obtain the desired end-product properties. A model-based computer...

  18. Computer aided design of free-machinability prehardened mold steel for plastic

    Institute of Scientific and Technical Information of China (English)

    HE Yan-lin; LI Lin; GAO Wen; WANG Qing-liang; WU Xiao-chun

    2005-01-01

    In order to improve the machinability but not to impair other properties of the prehardened mold steel for plastic, the composition was designed by application of Thermo-Calc software package to regulate the type of nonmetallic inclusion formed in the steel. The regulated non-metallic inclusion type was also observed by SEM and EDX. Then the maehinability assessment of the steel with designed composition under different conditions was studied by the measurement of tool wear amount and cutting force. The results show that the composition of free cutting elements adding to mold steel for plastic can be optimized to obtain proper type of non-metallic inclusion in the aid of Thermo-Calc, compared with the large volume fraction of soft inclusion which is needed for promoting ductile fracture at low cutting speeds, the proper type of inclusion at high cutting speeds is glassy oxide inclusion. All those can be obtained in the present work.

  19. Computer-Aided Modelling of Short-Path Evaporation for Chemical Product Purification, Analysis and Design

    DEFF Research Database (Denmark)

    Sales-Cruz, Alfonso Mauricio; Gani, Rafiqul

    2006-01-01

    An important stage in the design process for many chemical products is its manufacture where, for a class of chemical products that may be thermally unstable (such as, drugs, insecticides, flavours /fragrances, and so on), the purification step plays a major role. Short-path evaporation is a safe...... method, suitable for separation and purification of thermally unstable materials whose design and analysis can be efficiently performed through reliable model-based techniques. This paper presents a generalized model for short-path evaporation and highlights its development, implementation and solution...... glycerol, mono-, di- and triglycerides, and (b) the recovery of a pharmaceutical product from a six-component mixture. Validation of the short-path evaporation model is highlighted through the comparison of experimental data from an industrial pilot plant with the simulated results from the model. Also...

  20. Advanced earth observation spacecraft computer-aided design software: Technical, user and programmer guide

    Science.gov (United States)

    Farrell, C. E.; Krauze, L. D.

    1983-01-01

    The IDEAS computer of NASA is a tool for interactive preliminary design and analysis of LSS (Large Space System). Nine analysis modules were either modified or created. These modules include the capabilities of automatic model generation, model mass properties calculation, model area calculation, nonkinematic deployment modeling, rigid-body controls analysis, RF performance prediction, subsystem properties definition, and EOS science sensor selection. For each module, a section is provided that contains technical information, user instructions, and programmer documentation.

  1. Computer-Aided Construction at Designing Reinforced Concrete Columns as Per Ec

    Directory of Open Access Journals (Sweden)

    Zielińska M.

    2015-02-01

    Full Text Available The article presents the authors’ computer program for designing and dimensioning columns in reinforced concrete structures taking into account phenomena affecting their behaviour and information referring to design as per EC. The computer program was developed with the use of C++ programming language. The program guides the user through particular dimensioning stages: from introducing basic data such as dimensions, concrete class, reinforcing steel class and forces affecting the column, through calculating the creep coefficient taking into account the impact of imperfection depending on the support scheme and also the number of mating members at load shit, buckling length, to generating the interaction curve graph. The final result of calculations provides two dependence points calculated as per methods of nominal stiffness and nominal curvature. The location of those points relative to the limit curve determines whether the column load capacity is assured or has been exceeded. The content of the study describes in detail the operation of the computer program and the methodology and phenomena which are indispensable at designing axially and eccentrically the compressed members of reinforced concrete structures as per the European standards.

  2. Computer-aided rational design of novel EBF analogues with an aromatic ring.

    Science.gov (United States)

    Wang, Shanshan; Sun, Yufeng; Du, Shaoqing; Qin, Yaoguo; Duan, Hongxia; Yang, Xinling

    2016-06-01

    Odorant binding proteins (OBPs) are important in insect olfactory recognition. These proteins bind specifically to insect semiochemicals and induce their seeking, mating, and alarm behaviors. Molecular docking and molecular dynamics simulations were performed to provide computational insight into the interaction mode between AgamOBP7 and novel (E)-β-farnesene (EBF) analogues with an aromatic ring. The ligand-binding cavity in OBP7 was found to be mostly hydrophobic due to the presence of several nonpolar residues. The interactions between the EBF analogues and the hydrophobic residues in the binding cavity increased in strength as the distance between them decreased. The EBF analogues with an N-methyl formamide or ester linkage had higher docking scores than those with an amide linkage. Moreover, delocalized π-π and electrostatic interactions were found to contribute significantly to the binding between the ligand benzene ring and nearby protein residues. To design new compounds with higher activity, four EBF analogues D1-D4 with a benzene ring were synthesized and evaluated based on their docking scores and binding affinities. D2, which had an N-methyl formamide group linkage, exhibited stronger binding than D1, which had an amide linkage. D4 exhibited particularly strong binding due to multiple hydrophobic interactions with the protein. This study provides crucial foundations for designing novel EBF analogues based on the OBP structure. Graphical abstract The design strategy of new EBF analogues based on the OBP7 structure.

  3. A comparative approach to computer aided design model of a dog femur.

    Science.gov (United States)

    Turamanlar, O; Verim, O; Karabulut, A

    2016-01-01

    Computer assisted technologies offer new opportunities in medical imaging and rapid prototyping in biomechanical engineering. Three dimensional (3D) modelling of soft tissues and bones are becoming more important. The accuracy of the analysis in modelling processes depends on the outline of the tissues derived from medical images. The aim of this study is the evaluation of the accuracy of 3D models of a dog femur derived from computed tomography data by using point cloud method and boundary line method on several modelling software. Solidworks, Rapidform and 3DSMax software were used to create 3D models and outcomes were evaluated statistically. The most accurate 3D prototype of the dog femur was created with stereolithography method using rapid prototype device. Furthermore, the linearity of the volumes of models was investigated between software and the constructed models. The difference between the software and real models manifests the sensitivity of the software and the devices used in this manner.

  4. Computer-aided design and engineering: A study of windmills in la Mancha (Spain)

    Energy Technology Data Exchange (ETDEWEB)

    Rojas-Sola, Jose Ignacio [Universidad de Jaen, Escuela Politecnica Superior, Campus de las Lagunillas, s/n, 23071 Jaen (Spain); Gonzalez, Miguel Angel Gomez-Elvira; Martin, Enrique Perez [Universidad Politecnica de Madrid, E.T.S. Ingenieros Agronomos, Ciudad Universitaria, 28080 Madrid (Spain)

    2006-08-15

    This article presents a detailed study, of the Manchegan windmill. This type of windmill is a central symbol in the story of Don Quijote de la Mancha, by Cervantes, which this year celebrates its 4th centenary, and to which this article pays homage. There exist no publications dealing with the technical aspects of these windmills. Studies have been carried out on windmills in the south of Spain, but no comparison has been made between the two types of windmill. This paper studies the technological conditions of the original Manchegan windmills. We carry out a wind evaluation of the region, calculate the power and momentum of the windmills and discuss the results obtained with a comparison with the type of Southern Spanish windmill. (author)

  5. TESTS METALLIC BIOMATERIALS FOR COMPUTER-AIDED DESIGN AND MANUFACTURING OF FIXED PROSTHETIC RESTORATIONS

    Directory of Open Access Journals (Sweden)

    Anna M. RYNIEWICZ

    2014-03-01

    Full Text Available A direct metal laser sintering method (DMLS is a new technology used for getting structures by the CAD/CAM procedures. The aim of the elaboration was a question of structural identification and setting strength parameters of titanium (Ticp and its alloy (Ti6Al4V which are used to serve as base for those permanent prosthetic supplements which are later manufactured with the employment of CAD/CAM systems. The research work was performed on Ticp samples – those which were intended for manufacture of structures by decrement milling working, and Ti6Al4V samples that comes from laser increment sintering of powder. According to the results obtained, the following conclusion has been derived: when strength aspect is discussed, the DMLS method is a preferred one for manufacturing of load structures in dentistry and may be an alternate way for the CAD/CAM system used in decrement processing.

  6. User-Friendly, Syntax Directed Input to a Computer Aided Design System.

    Science.gov (United States)

    1983-06-01

    indepen- dern-. oblems arise in both compu:er aided design and in software development as a result of multipla types cf computz , mUtiple languages...Base CONLAN. Ease CONLAN is defined cy three i- ms , a set of object types and cperations, syntax, and a comPuta-IoL model. It is defined with Primitive...ycsjum on Computer Hardware= DescrT:--c-: -Lanquaqes. ~ p. =-3’EEET73 28. H1Il, F. J., and Petezzcn, J. R., DjZt4- S Lt-= Ms : Hardware O~gan iza,,i.n cand

  7. On Idiosyncratic Systems. Part I. Idiosyncratic Systems. Part II. On Being Creative with Computer Aided Design.

    Science.gov (United States)

    1977-03-31

    indigenous and are not found in the gestalt of a rubber band l ine. The input equipmen t is a tablet that reports “x” , “y” , and limited “ z ” values...in a sketch have an important gestalt it a “window. ” The if lCt ( n o n “I the idea - .,ems relation to one ’s current thinking abc -:t the design...document, A painter of some renown was undergoing therapy , frequently doing dnawin:;r Consider a human- to-human encounter w i t h somebody and m a

  8. Biomimicry in Product Design through Materials Selection and Computer Aided Engineering

    Science.gov (United States)

    Alexandridis, G.; Tzetzis, D.; Kyratsis, P.

    2016-11-01

    The aim of this study is to demonstrate a 7-step methodology that describes the way nature can act as a source of inspiration for the design and the development of a product. Furthermore, it suggests special computerized tools and methods for the product optimization regarding its environmental impact i.e. material selection, production methods. For validation purposes, a garden chaise lounge that imitates the form of a scorpion was developed as a result for the case study and the presentation of the current methodology.

  9. Tolerance Backward Propagation Based on Manufacturing Difficulties in Computer-aided Tolerance Design

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The interval constraint can be applied in tolerance design iftolerances are considered as interval, and backward propagation can be used to realize tolerance synthesis in which tolerances are allocated to meet functional requirements. The intervals are tightened uniformly or according to interval width or nominal value of dimension in previous methods. A tolerance backward propagation method based on manufacturing difficulties is presented in this paper. In the new arithmetic, the interval is tightened according to the manufacturing difficulty of the interval. So it will be easy to manufacture and has lower manufacturing cost. Finally, the proposed arithmetic is tested on a practical example.

  10. ORACLS - A linear-quadratic-Gaussian computer-aided design package

    Science.gov (United States)

    Armstrong, E. S.

    1982-01-01

    ORACLS, an acronym denoting Optimal Regular Algorithms for the Control of Linear Systems, is a collection of FORTRAN coded subroutines dedicated to the formulation and solution of the Linear-Quadratic-Gaussian (LQG) design problem modeled in both continuous and discrete form. The ORACLS system is under continuous development at the NASA Langley Research Center, Hampton, Virginia, and is widely used by universities and industry within the U.S.A. The current (operational) ORACLS version as well as new software under development is described.

  11. DESIGN AN ADVANCE COMPUTER-AIDED TOOL FOR IMAGE AUTHENTICATION AND CLASSIFICATION

    Directory of Open Access Journals (Sweden)

    Rozita Teymourzadeh

    2013-01-01

    Full Text Available Over the years, advancements in the fields of digital image processing and artificial intelligence have been applied in solving many real-life problems. This could be seen in facial image recognition for security systems, identity registrations. Hence a bottleneck of identity registration is image processing. These are carried out in form of image preprocessing, image region extraction by cropping, feature extraction using Principal Component Analysis (PCA and image compression using Discrete Cosine Transform (DCT. Other processing include filtering and histogram equalization using contrast stretching is performed while enhancing the image as part of the analytical tool. Hence, this research work presents a universal integration image forgery detection analysis tool with image facial recognition using Black Propagation Neural Network (BPNN processor. The proposed designed tool is a multi-function smart tool with the novel architecture of programmable error goal and light intensity. Furthermore, its advance dual database increases the efficiency for high performance application. With the fact that, the facial image recognition will always, give a matching output or closest possible output image for every input image irrespective of the authenticity, the universal smart GUI tool is proposed and designed to perform image forgery detection with the high accuracy of ±2% error rate. Meanwhile, a novel structure that provides efficient automatic image forgery detection for all input test images for the BPNN recognition is presented. Hence, an input image will be authenticated before being fed into the recognition tool.

  12. Computer-Aided Design of Materials for use under High Temperature Operating Condition

    Energy Technology Data Exchange (ETDEWEB)

    Rajagopal, K. R.; Rao, I. J.

    2010-01-31

    The procedures in place for producing materials in order to optimize their performance with respect to creep characteristics, oxidation resistance, elevation of melting point, thermal and electrical conductivity and other thermal and electrical properties are essentially trial and error experimentation that tend to be tremendously time consuming and expensive. A computational approach has been developed that can replace the trial and error procedures in order that one can efficiently design and engineer materials based on the application in question can lead to enhanced performance of the material, significant decrease in costs and cut down the time necessary to produce such materials. The work has relevance to the design and manufacture of turbine blades operating at high operating temperature, development of armor and missiles heads; corrosion resistant tanks and containers, better conductors of electricity, and the numerous other applications that are envisaged for specially structured nanocrystalline solids. A robust thermodynamic framework is developed within which the computational approach is developed. The procedure takes into account microstructural features such as the dislocation density, lattice mismatch, stacking faults, volume fractions of inclusions, interfacial area, etc. A robust model for single crystal superalloys that takes into account the microstructure of the alloy within the context of a continuum model is developed. Having developed the model, we then implement in a computational scheme using the software ABAQUS/STANDARD. The results of the simulation are compared against experimental data in realistic geometries.

  13. Study of human performance in computer-aided architectural design: methods and analysis

    Energy Technology Data Exchange (ETDEWEB)

    Cuomo, D.L.

    1988-01-01

    The goal of this study was to develop a performance methodology which will be useful for evaluating human performance for different types of tasks on a given system and across different levels of complexity within a single task. To meet the above goals, performance measures that reflect meaningful changes in humans behavior during CAAD tasks were developed. These measures were based on models of human information processing. Two cognitively different architectural tasks formulated differed in terms of the stimulus-central processing component-response compatibility and the structuredness of their problem spaces. Methods of varying task complexity within each of these tasks were also developed to test the sensitivity of the performance measures across levels of complexity and to introduce variability into the humans design behavior. From the developed performance measures task complexity, type of task, and subjective effects on performance could be seen. It was also shown that some measures more directly reflected the computer-interaction aspects of the task while other measures reflected the cognitive design activity of the human.

  14. Computer-aided designing of immunosuppressive peptides based on IL-10 inducing potential

    Science.gov (United States)

    Nagpal, Gandharva; Usmani, Salman Sadullah; Dhanda, Sandeep Kumar; Kaur, Harpreet; Singh, Sandeep; Sharma, Meenu; Raghava, Gajendra P. S.

    2017-01-01

    In the past, numerous methods have been developed to predict MHC class II binders or T-helper epitopes for designing the epitope-based vaccines against pathogens. In contrast, limited attempts have been made to develop methods for predicting T-helper epitopes/peptides that can induce a specific type of cytokine. This paper describes a method, developed for predicting interleukin-10 (IL-10) inducing peptides, a cytokine responsible for suppressing the immune system. All models were trained and tested on experimentally validated 394 IL-10 inducing and 848 non-inducing peptides. It was observed that certain types of residues and motifs are more frequent in IL-10 inducing peptides than in non-inducing peptides. Based on this analysis, we developed composition-based models using various machine-learning techniques. Random Forest-based model achieved the maximum Matthews’s Correlation Coefficient (MCC) value of 0.59 with an accuracy of 81.24% developed using dipeptide composition. In order to facilitate the community, we developed a web server “IL-10pred”, standalone packages and a mobile app for designing IL-10 inducing peptides (http://crdd.osdd.net/raghava/IL-10pred/). PMID:28211521

  15. Computer aided analysis and design of industrial energy systems; Rechnergestuetzte Analyse und Konzeption industrieller Energiesysteme

    Energy Technology Data Exchange (ETDEWEB)

    Augenstein, Eckardt Marc Guenter

    2009-03-02

    In this dissertation the concept and implementation of a software system supporting the analysis and the design of industrial energy systems is presented. As a basis, a software framework was designed supplying a domain specific object model allowing the description of energy systems as well as the energy auditing projects performed with the software. Moreover, a set of graphical and textual editors needed to model the examined systems is part of the framework. On the other hand, the professional methods for analysis, assessment and optimization of energy systems are implemented in modules integrated into the system via a plug-in interface. The object model whose definition was based on a meta model approach allows the description of network like structures typical to energy systems. In order to keep track of the different work steps performed during an analysis project, these steps are reflected in the object model as ''method applications'' using a tree as the basic structure of a project. In order to allow the compatibility of information a set of conventions for the evaluation of energy flows and system balances was introduced. Moreover, all data elements used in modules or model components are derived from a central database guaranteeing a consistent usage of terms, descriptions, validity ranges and data types. The single professional modules like simulators or optimization methods access the object model via an appropriate software interface. Moreover, they make use of the framework's user interface engine by delivering a generic description of dialog screens and result reports. As all modules share the same set of objects modelling the components of the energy system surveyed, the flow of information from module to module can be designed virtually seamless. Compared to a number of stand-alone solutions, this integrated design approach has the advantage that by combining a set of specialized methods an overall solution for complex

  16. Pharmacological Targeting of AMP-Activated Protein Kinase and Opportunities for Computer-Aided Drug Design.

    Science.gov (United States)

    Miglianico, Marie; Nicolaes, Gerry A F; Neumann, Dietbert

    2016-04-14

    As a central regulator of metabolism, the AMP-activated protein kinase (AMPK) is an established therapeutic target for metabolic diseases. Beyond the metabolic area, the number of medical fields that involve AMPK grows continuously, expanding the potential applications for AMPK modulators. Even though indirect AMPK activators are used in the clinics for their beneficial metabolic outcome, the few described direct agonists all failed to reach the market to date, which leaves options open for novel targeting methods. As AMPK is not actually a single molecule and has different roles depending on its isoform composition, the opportunity for isoform-specific targeting has notably come forward, but the currently available modulators fall short of expectations. In this review, we argue that with the amount of available structural and ligand data, computer-based drug design offers a number of opportunities to undertake novel and isoform-specific targeting of AMPK.

  17. Application of computer-aided engineering optimum design method in aluminum profile extrusion mould

    Institute of Scientific and Technical Information of China (English)

    帅词俊; 肖刚; 倪正顺; 钟掘

    2003-01-01

    The finite element analysis and the optimum design of aluminum profile extrusion mould were investigated using the ANSYS software and its parameterized modeling method. The optimum dimensions of the mould were obtained. It is found that the stress distribution is very uneven, and the stress convergence is rather severe in the bridge of the aluminum profile extrusion mould. The optimum height of the mould is 70. 527 mm, and the optimum radius of dividing holes are 70. 182 mm and 80. 663 mm. Increasing the height of the mould in the range of 61. 282 mm to 70. 422 mm can prolong its longevity, but when the height is over 70. 422 mm, its longevity reduces.

  18. Computer Aided Design and Simulation of a Multiobjective Microstrip Patch Antenna for Wireless Applications

    Directory of Open Access Journals (Sweden)

    Chitra Singh

    2011-03-01

    Full Text Available The utility and attractiveness of microstrip antennas has made it ever more important to find ways to precisely determine the radiation patterns of these antennas. Taking benefit of the added processing power of today’s computers, electromagnetic simulators are emerging to perform both planar and 3D analysis of high-frequency structures. One such tool studied was IE3D, which is a program that utilizes method of moment. This paper makes an investigation of the method used by the program, and then uses IE3D software to construct microstrip antennas and analyze the simulation results. The antenna offers good electrical performance and at the same time preserves the advantages of microstrip antennas such as small size, easy to manufacture as no lumped components are employed in the design and thus, is low cost; and most importantly, it serves multiple wireless applications.

  19. Building a computer-aided design capability using a standard time share operating system

    Science.gov (United States)

    Sobieszczanski, J.

    1975-01-01

    The paper describes how an integrated system of engineering computer programs can be built using a standard commercially available operating system. The discussion opens with an outline of the auxiliary functions that an operating system can perform for a team of engineers involved in a large and complex task. An example of a specific integrated system is provided to explain how the standard operating system features can be used to organize the programs into a simple and inexpensive but effective system. Applications to an aircraft structural design study are discussed to illustrate the use of an integrated system as a flexible and efficient engineering tool. The discussion concludes with an engineer's assessment of an operating system's capabilities and desirable improvements.

  20. Computer aided analysis and design of industrial energy systems; Rechnergestuetzte Analyse und Konzeption industrieller Energiesysteme

    Energy Technology Data Exchange (ETDEWEB)

    Augenstein, Eckardt Marc Guenter

    2009-03-02

    In this dissertation the concept and implementation of a software system supporting the analysis and the design of industrial energy systems is presented. As a basis, a software framework was designed supplying a domain specific object model allowing the description of energy systems as well as the energy auditing projects performed with the software. Moreover, a set of graphical and textual editors needed to model the examined systems is part of the framework. On the other hand, the professional methods for analysis, assessment and optimization of energy systems are implemented in modules integrated into the system via a plug-in interface. The object model whose definition was based on a meta model approach allows the description of network like structures typical to energy systems. In order to keep track of the different work steps performed during an analysis project, these steps are reflected in the object model as ''method applications'' using a tree as the basic structure of a project. In order to allow the compatibility of information a set of conventions for the evaluation of energy flows and system balances was introduced. Moreover, all data elements used in modules or model components are derived from a central database guaranteeing a consistent usage of terms, descriptions, validity ranges and data types. The single professional modules like simulators or optimization methods access the object model via an appropriate software interface. Moreover, they make use of the framework's user interface engine by delivering a generic description of dialog screens and result reports. As all modules share the same set of objects modelling the components of the energy system surveyed, the flow of information from module to module can be designed virtually seamless. Compared to a number of stand-alone solutions, this integrated design approach has the advantage that by combining a set of specialized methods an overall solution for complex

  1. A 3D computer-aided design system applied to diagnosis and treatment planning in orthodontics and orthognathic surgery.

    Science.gov (United States)

    Motohashi, N; Kuroda, T

    1999-06-01

    The purpose of this article is to describe a newly developed 3D computer-aided design (CAD) system for the diagnostic set-up of casts in orthodontic diagnosis and treatment planning, and its preliminary clinical applications. The system comprises a measuring unit which obtains 3D information from the dental model using laser scanning, and a personal computer to generate the 3D graphics. When measuring the 3D shape of the model, to minimize blind sectors, the model is scanned from two different directions with the slit-ray laser beam by rotating the mounting angle of the model on the measuring device. For computed simulation of tooth movement, the representative planes, defined by the anatomical reference points, are formed for each individual tooth and are arranged along a guideline descriptive of the individual arch form. Subsequently, the 3D shape is imparted to each of the teeth arranged on the representative plane to form an arrangement of the 3D profile. When necessary, orthognathic surgery can be simulated by moving the mandibular dental arch three-dimensionally to establish the optimum occlusal relationship. Compared with hand-made set-up models, the computed diagnostic cast has advantages such as high-speed processing and quantitative evaluation on the amount of 3D movement of the individual tooth relative to the craniofacial plane. Trial clinical applications demonstrated that the use of this system facilitated the otherwise complicated and time-consuming mock surgery for treatment planning in orthognathic surgery.

  2. Computer aided design and analysis of Sapan Dalam open pit mine

    Energy Technology Data Exchange (ETDEWEB)

    Baafi, E.Y.; Milawarma, E.; Cusack, C. [University of Wollongong, Wollongong, NSW (Australia). Dept. of Civil and Mining Engineering

    1995-12-31

    The Sapan Dalam coal deposit of Indonesia consists of ten steeply dipping seams with thicknesses varying between 0.1 and 3.5 m and split by shale clay, silt and sandstone. The area contains four faults dipping about 75{degree} with four to 85 m vertical displacements. The complex nature of the deposit coupled with limited 27 exploration drillholes at an average spacing of 200 m made it difficult to create a realistic geological model. A three-dimensional gridded seam model gave a fair representation of the deposit. Attempts to create an optimum pit using the WHITTLE 3D pit optimiser proved unsuccessful since the pit optimiser is restricted to standard regular or fixed blocks. The gridded seam model was converted to a fixed block model prior to the optimum pit design. Smoothing and pit base controlling were also introduced to obtain a smoother pit. A mining scenario produced 3.6 million tonnes of coal, 28.4 million bcm of waste and 18.1 million US dollars revenue. 3 refs., 6 figs., 1 tab.

  3. Study on Dicyandiamide-Imprinted Polymers with Computer-Aided Design

    Directory of Open Access Journals (Sweden)

    Dadong Liang

    2016-10-01

    Full Text Available With the aid of theoretical calculations, a series of molecularly imprinted polymers (MIPs were designed and prepared for the recognition of dicyandiamide (DCD via precipitation polymerization using acetonitrile as the solvent at 333 K. On the basis of the long-range correction method of M062X/6-31G(d,p, we simulated the bonding sites, bonding situations, binding energies, imprinted molar ratios, and the mechanisms of interaction between DCD and the functional monomers. Among acrylamide (AM, N,N’-methylenebisacrylamide (MBA, itaconic acid (IA, and methacrylic acid (MAA, MAA was confirmed as the best functional monomer, because the strongest interaction (the maximum number of hydrogen bonds and the lowest binding energy occurs between DCD and MAA, when the optimal molar ratios for DCD to the functional monomers were used, respectively. Additionally, pentaerythritol triacrylate (PETA was confirmed to be the best cross-linker among divinylbenzene (DVB, ethylene glycol dimethacrylate (EGDMA, trimethylolpropane trimethylacrylate (TRIM, and PETA. This is due to the facts that the weakest interaction (the highest binding energy occurs between PETA and DCD, and the strongest interaction (the lowest binding energy occurs between PETA and MAA. Depending on the results of theoretical calculations, a series of MIPs were prepared. Among them, the ones prepared using DCD, MAA, and PETA as the template, the functional monomer, and the cross-linker, respectively, exhibited the highest adsorption capacity for DCD. The apparent maximum absorption quantity of DCD on the MIP was 17.45 mg/g.

  4. Planificación tridimensional y utilización de férulas Computer Aided Design/Computed Aided Manufacturing en cirugía ortognática

    Directory of Open Access Journals (Sweden)

    Samir Aboul-Hosn Centenero

    2014-07-01

    Full Text Available El presente trabajo se centra en explicar las ventajas que aporta la planificación tridimensional (3D y la confección de férulas quirúrgicas Computer Aided Design/Computed Aided Manufacturing (CAD/CAM en cirugía ortognática. La digitalización del entorno laboral es una realidad imparable en nuestra sociedad y, en nuestra especialidad, nos proporciona ventajas desde un punto de vista logístico, de precisión diagnóstica y en la confección de férulas quirúrgicas. Las tradicionales férulas quirúrgicas siguen un método de fabricación casi artesanal sometido a errores sistemáticos que se van acumulando a lo largo del proceso. Las férulas CAD/CAM se crean directamente a partir de imágenes que obtenemos de la tomografía computarizada o de la tomografía de haz cónico con lo que acortamos, digitalizamos y estandarizamos el proceso de confección disminuyendo la posibilidad de cometer errores derivados de la confección manual. Las imágenes 3D sobre las que podemos trabajar nos aportan ventajas respecto a la visualización bidimensional (2D ya que no hay una pérdida de información ni una superposición de estructuras anatómicas. En 3D podemos ver con mayor detalle puntos de referencia difíciles de visualizar en 2D y son imágenes idóneas para el estudio de asimetrías en el plano frontal.

  5. User-Centered Computer Aided Language Learning

    Science.gov (United States)

    Zaphiris, Panayiotis, Ed.; Zacharia, Giorgos, Ed.

    2006-01-01

    In the field of computer aided language learning (CALL), there is a need for emphasizing the importance of the user. "User-Centered Computer Aided Language Learning" presents methodologies, strategies, and design approaches for building interfaces for a user-centered CALL environment, creating a deeper understanding of the opportunities and…

  6. The Application of Computer Aided Design in Facial Fat Autograft%计算机辅助设计在面部脂肪充填术中的应用研究

    Institute of Scientific and Technical Information of China (English)

    王梦; 归来; 牛峰; 刘剑锋; 陈莹

    2014-01-01

    Objective To explore the application of computer aided design in facial fat autograft. Methods The technique of computer aided design was applied to determine the injection site and amount of autologous fat injection. According to preoperative planning, 6 patients with facial asymmetry were received facial fat autograft. Results All patients suffering from facial asymmetry were all satisfied with the effective results and the facial asymmetry deformity was corrected obviously. Conclusion Computer aided design technology is a useful method in individual facial fat autograft.%目的:探讨计算机辅助设计技术在面部脂肪充填术中的应用。方法术前应用计算机辅助设计技术,确定自体脂肪注射部位以及注射量,对6例面部不对称畸形患者进行脂肪充填术。结果所有病例术后效果明显,外观满意,面部不对称畸形得到了明显矫治。结论应用计算机辅助设计技术指导面部脂肪充填术,手术效果满意,是一种值得推广的方法。

  7. CAD Computer Aided Design

    DEFF Research Database (Denmark)

    Sigrist, F.(red.)

    Publikationen indeholder foredrag, oplæg og sammenfatning af diskussionerne på et seminar, der havde til formål at informere byggeriets parter om udviklingen omkring brug af edb i byggesektoren....

  8. CAD Computer Aided Design

    DEFF Research Database (Denmark)

    Sigrist, F.(red.)

    Publikationen indeholder foredrag, oplæg og sammenfatning af diskussionerne på et seminar, der havde til formål at informere byggeriets parter om udviklingen omkring brug af edb i byggesektoren....

  9. A new decomposition-based computer-aided molecular/mixture design methodology for the design of optimal solvents and solvent mixtures

    DEFF Research Database (Denmark)

    Karunanithi, A.T.; Achenie, L.E.K.; Gani, Rafiqul

    2005-01-01

    This paper presents a novel computer-aided molecular/mixture design (CAMD) methodology for the design of optimal solvents and solvent mixtures. The molecular/mixture design problem is formulated as a mixed integer nonlinear programming (MINLP) model in which a performance objective...... is to be optimized subject to structural, property, and process constraints. The general molecular/mixture design problem is divided into two parts. For optimal single-compound design, the first part is solved. For mixture design, the single-compound design is first carried out to identify candidates...... the design of an optimal extractant for the separation of acetic acid from water by liquid-liquid extraction. The results suggest that the new extractant would be able to perform better than the extractant being widely used for this separation. The second case study is an industrial problem involving...

  10. A Design Science Research Methodology for Developing a Computer-Aided Assessment Approach Using Method Marking Concept

    Science.gov (United States)

    Genemo, Hussein; Miah, Shah Jahan; McAndrew, Alasdair

    2016-01-01

    Assessment has been defined as an authentic method that plays an important role in evaluating students' learning attitude in acquiring lifelong knowledge. Traditional methods of assessment including the Computer-Aided Assessment (CAA) for mathematics show limited ability to assess students' full work unless multi-step questions are sub-divided…

  11. 牙冠延长术模板的计算机辅助设计与制作%Computer aided design and computer aided manufacture of template for crown lengthening

    Institute of Scientific and Technical Information of China (English)

    赵彦博; 吴琳; 唐晓琳; 郭琛

    2013-01-01

    PURPOSE:To introduce a method applied in computer aided design and computer aided manufacture (CADCAM) of template for crown lengthening.METHODS:Point cloud data of dental stone model of the patient in the plan of crown lengthening surgery was obtained by laser scanning.The following processes were carried out,constructing 3-D curve of the gingiva,drawing template outline on the triangle mesh model,shelling it for 3-D model of template,and transferring the data to rapid prototyping equipment for manufacture.RESULTS:3-D model of the template was preliminarily accomplished.The resin template was manufactured with rapid prototyping equipment.The fitness between resin template and plaster model was good.CONCLUSIONS:This method,as an integrated procedure including data acquisition,3-D computer modeling and fabrication by rapid prototyping,is feasible to implement CAD-CAM of template for crown lengthening.%目的:将计算机辅助设计与快速成型技术相结合,应用于牙冠延长术手术模板的设计与制作,初步探索可行的方案.方法:利用三维扫描仪对1位需行牙冠延长术患者的上颌牙列石膏模型进行扫描.遵循龈缘形态的美学原则,结合患者口腔实际情况,对点云数据进行编辑,生成代表龈缘形态的3D曲线.按照曲线位置确定模板区域,通过抽壳等操作获取模板的三维数据模型.最后将数据导入快速成型机,加工出树脂模板.结果:初步实现了牙冠延长术手术模板的计算机辅助设计与制作;提高了术中定位切口的速度和准确性.结论:计算机辅助设计与快速成型技术相结合制作牙冠延长术模板,为科学设计龈缘的位置和形态提供了一种可行的方法.

  12. Development of the computer-aided process planning (CAPP system for polymer injection molds manufacturing

    Directory of Open Access Journals (Sweden)

    J. Tepić

    2011-10-01

    Full Text Available Beginning of production and selling of polymer products largely depends on mold manufacturing. The costs of mold manufacturing have significant share in the final price of a product. The best way to improve and rationalize polymer injection molds production process is by doing mold design automation and manufacturing process planning automation. This paper reviews development of a dedicated process planning system for manufacturing of the mold for injection molding, which integrates computer-aided design (CAD, computer-aided process planning (CAPP and computer-aided manufacturing (CAM technologies.

  13. Improving the Design Process for Auto-body GD&T Based on Computer-Aided Design%车身GD&T设计流程改进

    Institute of Scientific and Technical Information of China (English)

    曾思铭; 沈利冰; 金隼; 储国平

    2011-01-01

    According to the needs of vehicle manufacturers'product design department, and in light to the defects in the traditional design process of GD&T, computer-aided design tools are used to optimize the design process of GD&T: analyzing and classifying the related auto-body parts feature data, positioning benchmarks, and setting up an auto-body GD&T knowledge database integrated with industry rules and expert knowledge.Based on this database, the Computer Aided Optimization Design System for auto-body GD&T is designed with UG secondary development tools.The System can reduce the reduplicated work in the design process, so as to shorten the design cycle and enhance the design efficiency.%根据汽车制造企业产品设计部门的需求,针对传统GD&T设计流程中存在的一些不足,运用计算机辅助设计工具来对其进行优化:运用数据库知识分析和归类车身零部件相关特征信息和基准信息等资料,并结合工程设计规则和专家知识搭建一个车身尺寸公差信息的知识数据库,在此基础上运用UG二次开发工具设计一个优化车身GD&T设计流程的计算机辅助设计系统,可用于减少GD&T设计流程中大量的重复性工作,以缩短设计周期,提高设计效率.

  14. A new decomposition-based computer-aided molecular/mixture design methodology for the design of optimal solvents and solvent mixtures

    DEFF Research Database (Denmark)

    Karunanithi, A.T.; Achenie, L.E.K.; Gani, Rafiqul

    2005-01-01

    and then the second part is solved to determine the optimal mixture. The decomposition of the CAMD MINLP model into relatively easy to solve subproblems is essentially a partitioning of the constraints from the original set. This approach is illustrated through two case studies. The first case study involves...... the design of an optimal extractant for the separation of acetic acid from water by liquid-liquid extraction. The results suggest that the new extractant would be able to perform better than the extractant being widely used for this separation. The second case study is an industrial problem involving......This paper presents a novel computer-aided molecular/mixture design (CAMD) methodology for the design of optimal solvents and solvent mixtures. The molecular/mixture design problem is formulated as a mixed integer nonlinear programming (MINLP) model in which a performance objective...

  15. Contributions on Computer Aided Manufacturing of Drill-Jig Bushings

    Directory of Open Access Journals (Sweden)

    Vasile Cojocaru

    2009-01-01

    Full Text Available The paper presents the steps for computer aided manufacturing (CAMof the bushings technological class parts: design of the part in CADsoftware; generation of the parametrical link with MSExcel files; extract of the useful information for the technological design (mass, volume, surfaces; setting of the CNC lathe and necessary tools; programming of the CNC code for manufacturing. Given the large variety of the bushingsshapes and dimensions, the application focused on the jig bushings used in drilling processes.

  16. Research progress on computer-aided molecular design for polymer%CAMD技术在高分子领域应用的研究进展

    Institute of Scientific and Technical Information of China (English)

    王金强

    2016-01-01

    以计算机辅助分子设计(CAMD)技术为基础,综述了CAMD技术的发展现状以及在高分子领域,特别是在高分子树脂领域应用的研究进展。基于基团贡献法的CAMD技术既可以预测分子的相关性质,还可以进行高分子的设计,但在解决基团自动组合形成实际分子的问题上还有很多不足。CAMD技术在高分子领域应用广泛,可以对高分子树脂的性能进行预测以及用于设计树脂基复合材料,但CAMD技术还有很多缺陷。在分析与总结CAMD技术存在问题的基础上,对其发展趋势进行了探讨。%This paper reviews the development and application of computer-aided molecular design (CAMD) in polymer material, particularly polymer resin in recent years based on this technology. CAMD is developed on the basis of group contribution method, it is used for prediction of the properties of molecules and design for high molecules. However, there exists many problems such as resolving automatic formation of actual molecule with groups. CAMD is widely used in predicting the performance of polymer resin and design for resin-based composites. The technical problems of the technology are analyzed and summarized to probe into its development trend.

  17. Testing the design and placement of ORUs for robotic/EVA maintenance with computer-aided simulation

    Science.gov (United States)

    Leonard, J. W.

    NASA's Space Station Freedom will have a service life sufficiently long to entail extensive robotic and EVA maintenance activities associated with orbital replaceable units (ORUs). Attention is presently given to the results of computer-aided simulations of such activities which were conducted in order to ascertain preferable locations for suitably robotically- and EVA-accessible ORUs. Extensive attention has been given to operations involving the various possible positions of Freedom's airlock doors.

  18. Computer-Aided Modeling Framework

    DEFF Research Database (Denmark)

    Fedorova, Marina; Sin, Gürkan; Gani, Rafiqul

    with them. As the required models may be complex and require multiple time and/or length scales, their development and application for product-process design is not trivial. Therefore, a systematic modeling framework can contribute by significantly reducing the time and resources needed for model...... development and application. The proposed work is a part of the project for development of methods and tools that will allow systematic generation, analysis and solution of models for various objectives. It will use the computer-aided modeling framework that is based on a modeling methodology, which combines....... In this contribution, the concept of template-based modeling is presented and application is highlighted for the specific case of catalytic membrane fixed bed models. The modeling template is integrated in a generic computer-aided modeling framework. Furthermore, modeling templates enable the idea of model reuse...

  19. Computer Aided Lecturing.

    Science.gov (United States)

    Van Meter, Donald E.

    1994-01-01

    Surveyed students taking a natural resource conservation course to determine the effects of computer software that provides tools for creating and managing visual presentations to students. Results indicated that 94% of the respondents believed computer-aided lectures helped them and recommended their continued use; note taking was more effective,…

  20. Computer aided surface representation

    Energy Technology Data Exchange (ETDEWEB)

    Barnhill, R.E.

    1989-02-09

    The central research problem of this project is the effective representation and display of surfaces, interpolating to given information, in three or more dimensions. In a typical problem, we wish to create a surface from some discrete information. If this information is itself on another surface, the problem is to determine a surface defined on a surface,'' which is discussed below. Often, properties of an already constructed surface are desired: such geometry processing'' is described below. The Summary of Proposed Research from our original proposal describes the aims of this research project. This Summary and the Table of Contents from the original proposal are enclosed as an Appendix to this Progress Report. The broad sweep from constructive mathematics through algorithms and computer graphics displays is utilized in the research. The wide range of activity, directed in both theory and applications, makes this project unique. Last month in the first Ardent Titan delivered in the State of Arizona came to our group, funded by the DOE and Arizona State University. Although the Titan is a commercial product, its newness requires our close collaboration with Ardent to maximize results. During the past year, four faculty members and several graduate research assistants have worked on this DOE project. The gaining of new professionals is an important aspect of this project. A listing of the students and their topics is given in the Appendix. The most significant publication during the past year is the book, Curves and Surfaces for Computer Aided Geometric Design, by Dr. Gerald Farin. This 300 page volume helps fill a considerable gap in the subject and includes many new results on Bernstein-Bezier curves and surfaces.

  1. Information and computer-aided system for structural materials

    Energy Technology Data Exchange (ETDEWEB)

    Nekrashevitch, Yu.G.; Nizametdinov, Sh.U.; Polkovnikov, A.V.; Rumjantzev, V.P.; Surina, O.N. (Engineering Physics Inst., Moscow (Russia)); Kalinin, G.M.; Sidorenkov, A.V.; Strebkov, Yu.S. (Research and Development Inst. of Power Engineering, Moscow (Russia))

    1992-09-01

    An information and computer-aided system for structural materials data has been developed to provide data for the fusion and fission reactor system design. It is designed for designers, industrial engineers, and material science specialists and provides a friendly interface in an interactive mode. The database for structural materials contains the master files: Chemical composition, physical, mechanical, corrosion, technological properties, regulatory and technical documentation. The system is implemented on a PC/AT running the PS /2 operating system. (orig.).

  2. Preconditioner and convergence study for the Quantum Computer Aided Design (QCAD) nonlinear poisson problem posed on the Ottawa Flat 270 design geometry.

    Energy Technology Data Exchange (ETDEWEB)

    Kalashnikova, Irina

    2012-05-01

    A numerical study aimed to evaluate different preconditioners within the Trilinos Ifpack and ML packages for the Quantum Computer Aided Design (QCAD) non-linear Poisson problem implemented within the Albany code base and posed on the Ottawa Flat 270 design geometry is performed. This study led to some new development of Albany that allows the user to select an ML preconditioner with Zoltan repartitioning based on nodal coordinates, which is summarized. Convergence of the numerical solutions computed within the QCAD computational suite with successive mesh refinement is examined in two metrics, the mean value of the solution (an L{sup 1} norm) and the field integral of the solution (L{sup 2} norm).

  3. Integral system for computer aided design of power line transmission towers; Sistema integral para el diseno asistido por computadora de torres de transmision

    Energy Technology Data Exchange (ETDEWEB)

    Nagore, Gabriel [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)

    1986-12-31

    The profitable use of the advantages offered by the computer aided design, through the integral system for the structural design of power transmission towers (SIDETT) will contribute to facilitate and improve the design of the structures that link the electric power generation centers with the consumers. [Espanol] El aprovechamiento de las ventajas que ofrece el diseno asistido por computadora, a traves del sistema integral para el diseno estructural de torres de transmision (SIDETT), contribuira a agilizar y mejorar el diseno de las estructuras que enlazan los centros de generacion de energia electrica con los consumidores.

  4. Microstereolithography-based computer-aided manufacturing for tissue engineering.

    Science.gov (United States)

    Cho, Dong-Woo; Kang, Hyun-Wook

    2012-01-01

    Various solid freeform fabrication technologies have been introduced for constructing three-dimensional (3-D) freeform structures. Of these, microstereolithography (MSTL) technology performs the best in 3-D space because it not only has high resolution, but also fast fabrication speed. Using this technology, 3-D structures with mesoscale size and microscale resolution are achievable. Many researchers have been trying to apply this technology to tissue engineering to construct medically applicable scaffolds, which require a 3-D shape that fits a defect with a mesoscale size and microscale inner architecture for efficient regeneration of artificial tissue. This chapter introduces the principles of MSTL technology and representative systems. It includes fabrication and computer-aided design/computer-aided manufacturing (CAD/CAM) processes to show the automation process by which measurements from medical images are used to fabricate the required 3-D shape. Then, various tissue engineering applications based on MSTL are summarized.

  5. Computer aided design and computer aided manufacture of templates in dental implantation%牙种植定位导向模板的计算机辅助设计和制作

    Institute of Scientific and Technical Information of China (English)

    刘丽娜; 杨敏; 哈斯·巴根; 肖玲; 樊洪

    2012-01-01

    BACKGROUND: Currently, the templates widely used in implant surgery in China were prepared on plaster model. As the three-dimensional structure of the jaw is unclear, accurate implanting is difficult and complications of implantation are prone to exist.OBJECTIVE: To prepare oral implant templates with CT and computer aided design (CAD)/computer aided manufacture (CAM) in order to locate implants in the right position and direction.METHODS: Plaster models of maxillary edentulous with location marker were scanned with CT. The MIMICS software was used to reconstruct three-dimensional model and simulate implantation. Simulated implant was located in the ideal position based on the anatomical structure of the implanted jaw and the implanted methods according to prosthetic and aesthetic requests. The information of position angle of the simulated implant was transferred to the template while it was prepared. The data were input rapid prototyping equipment to prepare resin template. The accuracy of the template was tested after implantation in it.RESULTS AND CONCLUSION: The top deviation of the implant was (0.87±0.21) mm and the bottom deviation was (0.82± 0.16) mm after implantation. The deviation of the implant in the vertical direction was slightly bigger than those in the buccolingual direction and mesiodistal direction. The implant design can be accurately transferred to the template before operation.Implantation can be well guided using this, and it can improve the safety, accuracy and the successful rate.%背景:目前国内广泛使用的种植模板是在石膏模型上制作完成,由于无法明确植入区颌骨的三维结构,因此不能准确地指导种植体植入,容易导致植体植入并发症.目的:利用CT技术、计算机辅助设计/计算机辅助制作技术设计制作口腔种植模板,以准确定位种植体植入的位置和方向.方法:CT扫描带有定位标记的上颌游离缺失石膏模型.在软件MIMICS中进行三维重建和

  6. Double scanning method for computer aided design and computer aided manufacture all-ceramic restorations%氧化锆全瓷修复中二次扫描的初步应用

    Institute of Scientific and Technical Information of China (English)

    刘亦洪; 冯海兰; 王海涛; 王琳; 聂宇光; 王涛

    2010-01-01

    Objective To introduce the double scanning for producing computer aided design and computer aided manufacture (CAD-CAM) zirconia crowns,and to compare Procera with Everest CAD-CAM system by observing clinical effects of the crowns.Methods Forty CAD-CAM zirconia crowns (10 crowns by Procera,and 30 crowns by Everest) were evaluated,and the examination criteria included:marginal fit,aesthetics,gingival health,retention,and fracture.All of the zirconia copings were produced using double scanning.Procera system and Everest system use contact scanner and optical scanner respectively. Results The observation time for the crowns ranged from 6 to 24 months.The resulm of clinic evaluation were acceptable in all restorations.Conclusions Double scanning could be used to produce complicated zirconia copings by CAD-CAM in order to get proper symmetrical porcelain length.It Wag easier to make complicated coping with contact scanuer than with optical scanner.%目的 观察二次扫描在制作计算机辅助设计与辅助制作(CAD-CAM)氧化锆全瓷冠中的临床效果,并对比不同扫描系统在此过程中的可操作性,以期为临床提供参考.方法 应用二次扫描完成氧化锆全瓷冠40件,其中Proeera全瓷冠10件(使用接触式扫描仪),Everest全瓷冠30件(使用光学扫描仪).利用二次扫描制作不同形态的基底冠.修复后1 d、3、6、12、24个月进行临床检查,内容包括边缘适合性、颜色、固位、折断或破损情况.结果 40件全瓷冠随访6~24个月,平均12个月.临床检查中40件全瓷冠的各项检查结果均为满意.结论 二次扫描可以完成复杂形态的CADCAM氧化锆基底冠的制作,保证氧化锆全瓷冠饰瓷厚度均匀适度.应用二次扫描时,光学扫描仪相比接触式扫描仪更适合于完成复杂形态的氧化锆基底冠.

  7. Progress of the Computer-Aided Engineering of Electric Drive Vehicle Batteries (CAEBAT) (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Pesaran, A. A.; Han, T.; Hartridge, S.; Shaffer, C.; Kim, G. H.; Pannala, S.

    2013-06-01

    This presentation, Progress of Computer-Aided Engineering of Electric Drive Vehicle Batteries (CAEBAT) is about simulation and computer-aided engineering (CAE) tools that are widely used to speed up the research and development cycle and reduce the number of build-and-break steps, particularly in the automotive industry. Realizing this, DOE?s Vehicle Technologies Program initiated the CAEBAT project in April 2010 to develop a suite of software tools for designing batteries.

  8. 计算机辅助园林设计应用探讨%Application of Computer Aided Landscape Architecture Design

    Institute of Scientific and Technical Information of China (English)

    许大为; 杨彤彤

    2012-01-01

    计算机辅助设计已成为当今园林设计师的一种重要设计手法,其方便快捷和富于创造性的感受性和视觉冲击性,被广泛应用于园林设计的各个阶段。随着园林专业和计算机行业的迅猛发展,两者的结合开发出现了新的挑战。该文从计算机辅助设计的角度,分析其在园林设计中的应用形式以及优缺点,并对今后的发展方向进行探讨。%Computer aided design has become an important design technique for landscape designers.Because of its convenience, creative feeling and visual impact ,it was widely used in landscape design phases. With the development of landscape architecture specialty and the rapid development of computer industry, the combination of the two development appears new advantages and challenges.From the computer aided design angle, this article analyzed its application in landscape design and application forms as well as the advantages and disadvantages,and the future development and direction.

  9. Basic studies on computer aided concurrent engineering for hull structure design and piping design; Kakugi ittai wo koryoshita doji heikotekina sekkei no shien ni kansuru kisoteki kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    Aoyama, K.; Sawada, K. [The University of Tokyo, Tokyo (Japan)

    1996-12-31

    Considering integrated hull and piping design in shipbuilding industry as a good example for concurrent engineering (CE), discussions were given on a computer aided method to perform integrated hull and piping design smoothly. When CE aiding by means of a computer is considered, it is important to discuss a method for information management not only for `utilization of product models`, but also for `maintaining consistency between items of product information` and `concurrent utilization and production of product information` in concurrent designs. For the CE aided information management, utilization and production of the product information is effective if restrictive relationship between items of product information, and design functions are made clear. Definitions were given on the restrictive relationship between items of product information and `restrictive relationship information` that has `decision/provisional decision`, `date and time`, `designer` and `design functions`. Furthermore, `comprehensive relationship between items of product information` that can be produced from the restrictive relationship information was defined as a `restrictive network`. Utilizing the restrictive relationship between items of product information for CE aiding is effective. 9 refs., 14 figs.

  10. Development of Computer Aided Modelling Templates for Model Re-use in Chemical and Biochemical Process and Product Design: Importand export of models

    DEFF Research Database (Denmark)

    2015-01-01

    been established, in order to provide a wider range of modelling capabilities. Through this link, developed models can be exported/imported to/from other modelling-simulation software environments to allow model reusability in chemical and biochemical product and process design. The use of this link......This paper focuses on the challenges in model development related to model reuse and compatibility and integration of different tools that are used in modelling. A link between two modelling tools, the computer-aided modelling framework of the ICAS system and the modelling environment, MOSAIC, has...

  11. Drug Design Workshop: A Web-Based Educational Tool to Introduce Computer-Aided Drug Design to the General Public

    Science.gov (United States)

    Daina, Antoine; Blatter, Marie-Claude; Gerritsen, Vivienne Baillie; Palagi, Patricia M.; Marek, Diana; Xenarios, Ioannis; Schwede, Torsten; Michielin, Olivier; Zoete, Vincent

    2017-01-01

    Due to its impact on society, the design of new drugs has the potential to interest a wide audience, and provides a rare opportunity to introduce several concepts in chemistry and biochemistry. Drug design can be seen as a multiobjective cyclic optimization process. Indeed, it is important to develop the understanding not only that a drug is…

  12. A New Approach to Develop Computer-Aided Diagnosis Scheme of Breast Mass Classification Using Deep Learning Technology.

    Science.gov (United States)

    Qiu, Yuchen; Yan, Shiju; Gundreddy, Rohith Reddy; Wang, Yunzhi; Cheng, Samuel; Liu, Hong; Zheng, Bin

    2017-04-18

    To develop and test a deep learning based computer-aided diagnosis (CAD) scheme of mammograms for classifying between malignant and benign masses. An image dataset involving 560 regions of interest (ROIs) extracted from digital mammograms was used. After down-sampling each ROI from 512×512 to 64×64 pixel size, we applied an 8 layer deep learning network that involves 3 pairs of convolution-max-pooling layers for automatic feature extraction and a multiple layer perceptron (MLP) classifier for feature categorization to process ROIs. The 3 pairs of convolution layers contain 20, 10, and 5 feature maps, respectively. Each convolution layer is connected with a max-pooling layer to improve the feature robustness. The output of the sixth layer is fully connected with a MLP classifier, which is composed of one hidden layer and one logistic regression layer. The network then generates a classification score to predict the likelihood of ROI depicting a malignant mass. A four-fold cross validation method was applied to train and test this deep learning network. The results revealed that this CAD scheme yields an area under the receiver operation characteristic curve (AUC) of 0.696±0.044, 0.802±0.037, 0.836±0.036, and 0.822±0.035 for fold 1 to 4 testing datasets, respectively. The overall AUC of the entire dataset is 0.790±0.019. This study demonstrates the feasibility of applying a deep learning based CAD scheme to classify between malignant and benign breast masses without a lesion segmentation, image feature computation and selection process.

  13. Computer Aided Drug Design for Multi-Target Drug Design: SAR /QSAR, Molecular Docking and Pharmacophore Methods.

    Science.gov (United States)

    Abdolmaleki, Azizeh; Ghasemi, Jahan B; Ghasemi, Fatemeh

    2017-01-01

    Multi-target drugs against particular multiple targets get better protection, resistance profiles and curative influence by cooperative rules of a key beneficial target with resistance behavior and compensatory elements. Computational techniques can assist us in the efforts to design novel drugs (ligands) with a preferred bioactivity outline and alternative bioactive molecules at an early stage. A number of in silico methods have been explored extensively in order to facilitate the investigation of individual target agents and to propose a selective drug. A different, progressively more significant field which is used to predict the bioactivity of chemical compounds is the data mining method. Some of the previously mentioned methods have been investigated for multi-target drug design (MTDD) to find drug leads interact simultaneously with multiple targets. Several cheminformatics methods and structure-based approaches try to extract information from units working cooperatively in a biomolecular system to fulfill their task. To dominate the difficulties of the experimental specification of ligand-target structures, rational methods, namely molecular docking, SAR and QSAR are vital substitutes to obtain knowledge for each structure in atomic insight. These procedures are logically successful for the prediction of binding affinity and have shown promising potential in facilitating MTDD. Here, we review some of the important features of the multi-target therapeutics discoveries using the computational approach, highlighting the SAR, QSAR, docking and pharmacophore methods to discover interactions between drug-target that could be leveraged for curative benefits. A summary of each, followed by examples of its applications in drug design has been provided. Computational efficiency of each method has been represented according to its main strengths and limitations. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  14. Enhanced Thermostability of Lipoxygenase from Anabaena sp. PCC 7120 by Site-Directed Mutagenesis Based on Computer-Aided Rational Design.

    Science.gov (United States)

    Diao, Hanwen; Zhang, Chong; Wang, Shuicheng; Lu, Fengxia; Lu, Zhaoxin

    2016-04-01

    Lipoxygenase from Anabaena sp. PCC 7120 (Ana-LOX) was thermally unstable. So, improving the thermostability of the enzyme was quite essential. The target site of Ana-LOX selected for site-directed mutagenesis was based on computer-aided rational design. The thermostability and specific activity of Ana-LOX were improved with replacing valine with alanine at the target site 421 and the site 40. Compared to the wild-type enzyme which has a half-life (T 1/2) of inactivation of 3.8 min at 50 °C, the T 1/2 of mutant enzymes with V421A and V40A substitution increased to 4.4 and 7.0 min, respectively. The double mutant V421A/V40A showed a synergistic effect with a T 1/2 value of 8.3 min, resulting in a 1.18-fold improvement compared to the original Ana-LOX. V421A, V40A, and V421A/V40A also obtained 4.83, 41.58, and 80.07 % increase in specific activity, respectively. This study provides useful theoretical reference for enzyme molecular modification and computer-aided rational design.

  15. Design of an enhanced fuzzy k-nearest neighbor classifier based computer aided diagnostic system for thyroid disease.

    Science.gov (United States)

    Liu, Da-You; Chen, Hui-Ling; Yang, Bo; Lv, Xin-En; Li, Li-Na; Liu, Jie

    2012-10-01

    In this paper, we present an enhanced fuzzy k-nearest neighbor (FKNN) classifier based computer aided diagnostic (CAD) system for thyroid disease. The neighborhood size k and the fuzzy strength parameter m in FKNN classifier are adaptively specified by the particle swarm optimization (PSO) approach. The adaptive control parameters including time-varying acceleration coefficients (TVAC) and time-varying inertia weight (TVIW) are employed to efficiently control the local and global search ability of PSO algorithm. In addition, we have validated the effectiveness of the principle component analysis (PCA) in constructing a more discriminative subspace for classification. The effectiveness of the resultant CAD system, termed as PCA-PSO-FKNN, has been rigorously evaluated against the thyroid disease dataset, which is commonly used among researchers who use machine learning methods for thyroid disease diagnosis. Compared to the existing methods in previous studies, the proposed system has achieved the highest classification accuracy reported so far via 10-fold cross-validation (CV) analysis, with the mean accuracy of 98.82% and with the maximum accuracy of 99.09%. Promisingly, the proposed CAD system might serve as a new candidate of powerful tools for diagnosing thyroid disease with excellent performance.

  16. 人力资源规划计算机辅助预测模型的设计%Computer Aided Prediction Model Design of Human Resources Planning

    Institute of Scientific and Technical Information of China (English)

    俞明; 余浩洋

    2013-01-01

    From the current situation of human resource planning, combined with the content and process of human resources plan, it designs the model of computer aided design prediction, and explains the basic structure and mathematic model. It designs an application model of human resources planning. It has done a total and classified planning, and has analyzed the results.%  从人力资源规划现状出发,结合人力资源规划的内容和步骤,进行了计算机辅助预测模型的设计,说明了其基本结构和数学模型。设计了人力资源规划的应用示例,进行了总量规划和分类规划,并对规划结果进行了分析,提出解决策略。

  17. 计算机辅助工业设计软件教学研究%Research on the Teaching of Computer Aided Industrial Design Software

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    Computer Aided Industrial Design (CAID) software is very important for product styling design. This article discusses the method of current software teaching, analyses the way to im-prove the problems and tries to propose new ideas for CAID soft-ware teaching.%  计算机辅助工业设计(CAID)软件是进行产品造型设计的重要工具。本文结合实际教学经验,针对现阶段软件教学中教学思路、手段、方式等方面存在的问题进行了探讨,分析其中存在的弊病并尝试提出改进软件教学的方法。

  18. 计算机辅助药物设计在中药作用靶点研究中的应用%The study of Traditional Chinese Medicine-target using computer-aided drug design

    Institute of Scientific and Technical Information of China (English)

    吴可柱; 左颖; 李爱秀

    2012-01-01

    Traditional Chinese Medicine(TCM) has a three-thousand-year history in China, many of which are still widely used in clinical practice today. As the mechanisms and medicine-target of Chinese herbal medicine have not been elucidated yet, thus, the modernization process of TCM appears to be hindered. Computer aided drug design is a new technology used in drug research and development with the developing of some subjects, such as molecular biology and computer science. CADD is based on the theoretic point of view, so the blindness significantly decreased in drug research. In this article, some means of CADD including molecular docking, drug-target network and pharmacophore were summaried. Besides, the methods and the strategies of these technologies using in the Traditional Chinese Medicine-target were also introduced. It is believed that computer-aided drug design used as a effective techniques in the study of Traditional Chinese Medicine-target will no doubt play an important part in promoting modernization of TCM.%传统中药在我国有着近三千年的悠久历史,许多方剂至今仍被人们广泛用于临床.但由于中药作用机制及其靶点的不明确,阻碍了实现中药现代化的进程.计算机辅助药物设计(computer-aided drug design,CADD)是随着分子生物学、计算机科学等相应学科发展而研发的一种新的药物研究手段,CADD从理论角度出发,大大减少了药物研发的盲目性.本文就CADD的一些常用技术手段进行了综述,并对各项技术用于中药作用靶点研究的方法、策略以及应用实例进行了介绍.作为一种有效的技术手段,CADD在对中药作用靶点的预测以及推动中药现代化发展方面必将发挥重要作用.

  19. A preliminary study on the short-term efficacy of chairside computer-aided design/computer-assisted manufacturing- generated posterior lithium disilicate crowns.

    Science.gov (United States)

    Reich, Sven; Fischer, Sören; Sobotta, Bernhard; Klapper, Horst-Uwe; Gozdowski, Stephan

    2010-01-01

    The purpose of this preliminary study was to evaluate the clinical performance of chairside-generated crowns over a preliminary time period of 24 months. Forty-one posterior crowns made of a machinable lithium disilicate ceramic for full-contour crowns were inserted in 34 patients using a chairside computer-aided design/computer-assisted manufacturing technique. The crowns were evaluated at baseline and after 6, 12, and 24 months according to modified United States Public Health Service criteria. After 2 years, all reexamined crowns (n = 39) were in situ; one abutment exhibited secondary caries and two abutments received root canal treatment. Within the limited observation period, the crowns revealed clinically satisfying results.

  20. Inhibitory effect of isothiocyanate derivant targeting AGPS by computer-aid drug design on proliferation of glioma and hepatic carcinoma cells.

    Science.gov (United States)

    Zhu, Yu; Li, Wen-Ming; Zhang, Ling; Xue, Jing; Zhao, Meng; Yang, Ping

    2015-01-01

    Lipids metabolism was involved in the process of many types of tumor and alkylglycerone phosphate synthase (AGPS) was considered implicated in tumor process. Benzyl isothiocyanate (BITC) showed the inhibitory effect of tumor and AGPS activity, therefore, we screened a group of small molecular compound based on BITC by computer-aid design targeting AGPS and the results showed that the derivants could suppress the proliferation, the expression of tumor related genes such as survivin and Bcl-2, and the level of ether lipids such as lysophosphatidic acid ether (LPAe) and platelet activating factor ether (PAFe); however, the activity of caspase-3/8 was improved in glioma U87MG and hepatic carcinoma HepG2 cells in vitro.

  1. Computer-aided design–computer-aided engineering associative feature-based heterogeneous object modeling

    Directory of Open Access Journals (Sweden)

    Jikai Liu

    2015-12-01

    Full Text Available Conventionally, heterogeneous object modeling methods paid limited attention to the concurrent modeling of geometry design and material composition distribution. Procedural method was normally employed to generate the geometry first and then determine the heterogeneous material distribution, which ignores the mutual influence. Additionally, limited capability has been established about irregular material composition distribution modeling with strong local discontinuities. This article overcomes these limitations by developing the computer-aided design–computer-aided engineering associative feature-based heterogeneous object modeling method. Level set functions are applied to model the geometry within computer-aided design module, which enables complex geometry modeling. Finite element mesh is applied to store the local material compositions within computer-aided engineering module, which allows any local discontinuities. Then, the associative feature concept builds the correspondence relationship between these modules. Additionally, the level set geometry and material optimization method are developed to concurrently generate the geometry and material information which fills the contents of the computer-aided design–computer-aided engineering associative feature model. Micro-geometry is investigated as well, instead of only the local material composition. A few cases are studied to prove the effectiveness of this new heterogeneous object modeling method.

  2. Sustained regeneration of high-volume adipose tissue for breast reconstruction using computer aided design and biomanufacturing.

    Science.gov (United States)

    Chhaya, Mohit Prashant; Melchels, Ferry Petrus Wilhelmus; Holzapfel, Boris Michael; Baldwin, Jeremy Grant; Hutmacher, Dietmar Werner

    2015-06-01

    Adipose tissue engineering offers a promising alternative to the current breast reconstruction options. Here we investigated patient-specific breast scaffolds fabricated from poly(d,l)-lactide polymer with pore sizes>1 mm for their potential in long-term sustained regeneration of high volume adipose tissue. An optimised scaffold geometry was modelled in silico via a laser scanning data set from a patient who underwent breast reconstruction surgery. After the design process scaffolds were fabricated using an additive manufacturing technology termed fused deposition modelling. Breast-shaped scaffolds were seeded with human umbilical cord perivascular cells and cultured under static conditions for 4 weeks and subsequently 2 weeks in a biaxial rotating bioreactor. These in vitro engineered constructs were then seeded with human umbilical vein endothelial cells and implanted subcutaneously into athymic nude rats for 24 weeks. Angiogenesis and adipose tissue formation were observed throughout all constructs at all timepoints. The percentage of adipose tissue compared to overall tissue area increased from 37.17% to 62.30% between week 5 and week 15 (pbreast reconstruction. Copyright © 2015 Elsevier Ltd. All rights reserved.

  3. Computer Aided Learning of Mathematics: Software Evaluation

    Science.gov (United States)

    Yushau, B.; Bokhari, M. A.; Wessels, D. C. J.

    2004-01-01

    Computer Aided Learning of Mathematics (CALM) has been in use for some time in the Prep-Year Mathematics Program at King Fahd University of Petroleum & Minerals. Different kinds of software (both locally designed and imported) have been used in the quest of optimizing the recitation/problem session hour of the mathematics classes. This paper…

  4. Computer Aided Continuous Time Stochastic Process Modelling

    DEFF Research Database (Denmark)

    Kristensen, N.R.; Madsen, Henrik; Jørgensen, Sten Bay

    2001-01-01

    A grey-box approach to process modelling that combines deterministic and stochastic modelling is advocated for identification of models for model-based control of batch and semi-batch processes. A computer-aided tool designed for supporting decision-making within the corresponding modelling cycle...

  5. 三维计算机辅助设计——Solidworks课程中案例教学法的应用%3D Computer Aided Design--Solidworks application of case teaching method course

    Institute of Scientific and Technical Information of China (English)

    黄昊旻

    2012-01-01

    本文从三维计算机辅助设计课程的特点出发,论述三维计算机辅助设计课程中案例教学法的作用及应当注意的问题。%This article with regards to the characteristics of 3D Computer Aided Design course addressed in the course of three dimensional computer aided design of case teaching method and it should be noted that the role of problem

  6. Application of computer aids drug screening in new drug design and development%计算机模拟药物筛选在新药设计与开发中的应用

    Institute of Scientific and Technical Information of China (English)

    黄牛

    2001-01-01

    The development of computer technology, molecular pharmacology and molecular biology promoted the technique of in silico drug screening (virtual screening) used in the drug discovery. The in silico drug screening could be used for diversity screening and/or focussed screening. In present paper, the principles, characteristics and methods of computer aids drug screening were briefly described.

  7. Developing a New Framework for Integration and Teaching of Computer Aided Architectural Design (CAAD) in Nigerian Schools of Architecture

    Science.gov (United States)

    Uwakonye, Obioha; Alagbe, Oluwole; Oluwatayo, Adedapo; Alagbe, Taiye; Alalade, Gbenga

    2015-01-01

    As a result of globalization of digital technology, intellectual discourse on what constitutes the basic body of architectural knowledge to be imparted to future professionals has been on the increase. This digital revolution has brought to the fore the need to review the already overloaded architectural education curriculum of Nigerian schools of…

  8. Novel Ergonomic Postural Assessment Method (NERPA) Using Product-Process Computer Aided Engineering for Ergonomic Workplace Design

    Science.gov (United States)

    Sanchez-Lite, Alberto; Garcia, Manuel; Domingo, Rosario; Angel Sebastian, Miguel

    2013-01-01

    Background Musculoskeletal disorders (MSDs) that result from poor ergonomic design are one of the occupational disorders of greatest concern in the industrial sector. A key advantage in the primary design phase is to focus on a method of assessment that detects and evaluates the potential risks experienced by the operative when faced with these types of physical injuries. The method of assessment will improve the process design identifying potential ergonomic improvements from various design alternatives or activities undertaken as part of the cycle of continuous improvement throughout the differing phases of the product life cycle. Methodology/Principal Findings This paper presents a novel postural assessment method (NERPA) fit for product-process design, which was developed with the help of a digital human model together with a 3D CAD tool, which is widely used in the aeronautic and automotive industries. The power of 3D visualization and the possibility of studying the actual assembly sequence in a virtual environment can allow the functional performance of the parts to be addressed. Such tools can also provide us with an ergonomic workstation design, together with a competitive advantage in the assembly process. Conclusions The method developed was used in the design of six production lines, studying 240 manual assembly operations and improving 21 of them. This study demonstrated the proposed method’s usefulness and found statistically significant differences in the evaluations of the proposed method and the widely used Rapid Upper Limb Assessment (RULA) method. PMID:23977340

  9. Global sensitivity analysis of computer-aided molecular design problem for the development of novel working fluids for power cycles

    DEFF Research Database (Denmark)

    Frutiger, Jerome; Abildskov, Jens; Sin, Gürkan

    2016-01-01

    study involving the design of a working fluid for an Organic Ranking Cycle (ORC) design for power generation. Morris Screening is found to be favorable over Monte Carlo based standard regression. Monte Carlo based standard regression cannot be applied, because the current model cannot be sufficiently......This study compares two methods for global sensitivity analysis as a new approach for the identification and ranking of target properties in molecular design problems: A modified Morris Screening technique and Monte Carlo based standard regression. The two methodologies are highlighted in a case...

  10. Study on Approach for Computer-Aided Design and Machining of General Cylindrical Cam Using Relative Velocity and Inverse Kinematics

    Institute of Scientific and Technical Information of China (English)

    Se-Hwan; Park; Byong-Kook; Gu; Joong-Ho; Shin; Geun-Jong; Yoo

    2002-01-01

    Cylindrical Cam Mechanism which is one of the best eq uipments to accomplish an accurate motion transmission is widely used in the fie lds of industries, such as machine tool exchangers, textile machinery and automa tic transfer equipments. This paper proposes a new approach for the shape design and manufacturing of the cylindrical cam. The design approach uses the relative velocity concept and the manufacturing approach uses the inverse kinematics concept. For the shape desig n, the contact points betw...

  11. Computer-Aided Treatment Design of a Distal Upper Extremity Soft Tissue Tumor with Electron Beam Radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Li, Chun; Crawford, Susan; Mundt, A.J.; Vijayakumar, S.

    2015-01-15

    We present here a novel approach for the planning and treatment of a distal upper extremity soft tissue tumor. Utilizing computed tomography (CT) based electron dose calculations, a customized compensating wax bolus was designed in order to deliver sufficient dose coverage to the tumor volume while sparing the draining lymphatics of the patient’s hand and digits. A clinical case is presented as well as the design and construction of the compensator. Outcome and clinical implications are discussed.

  12. Spline curve fitting and graphic image digital vector quantization under computer aided technology%样条曲线拟合和计算机辅助技术下的图形图像数字矢量化

    Institute of Scientific and Technical Information of China (English)

    吴珊丹

    2016-01-01

    with the development of computer technology and Internet technology,automation technology,computer technolo⁃gy and network technology has been widely used in various aspects of the current life and work. In the process of social develop⁃ment,different types and structural products need to be produced to meet the different requirements of users. In order to reduce the production cost of the products,and improve the competitiveness of the market,design of the product manufacturing technol⁃ogy and optimization of the products should be strengthened in product design,manufacture and management. The graphic image vector quantization is a fast digital processing method,which can improve the quality of the product design,optimize the prod⁃uct design,effectively reduce the production cost,and improve market competitiveness. The analytical investigation for spline curve fitting,image digital vector quantization in computer aided technology,and the related contents is carried out in this pa⁃per.%在社会发展的过程中,需要生产不同类型、不同结构等的产品以满足用户的不同需求。为了降低产品的生产成本,并提高市场的竞争力,需要从产品的设计、制造、管理等方面入手,加强产品的设计,优化产品生产制造技术等。结果表明,应用图形图像数字数量化分析,可以提高产品设计的质量,优化设计,有效地降低生产成本,提高市场竞争力。

  13. Toward a Computer-Aided Synthesis and Design of Biorefinery Networks: Data Collection and Management Using a Generic Modeling Approach

    DEFF Research Database (Denmark)

    Cheali, Peam; Gernaey, Krist; Sin, Gürkan

    2014-01-01

    Recent research into biorefineries resulted in many competing concepts and technologies for conversion of renewable biobased feedstock into an array of promising products including fuels, chemicals, materials, etc. The topic of this study is collection and management of the complex biorefinery data...... parameters includes reaction yield, utility consumption, and separation efficiency among others, which are identified on the basis of input−output data (generated from rigorous models) collected from detailed biorefinery case studies reported in the open literature. The outcome is a verified database...

  14. Research Development about Computer Aided Design of Shell and Tube Heat Exchanger%管壳式热交换器计算机辅助设计研究进展

    Institute of Scientific and Technical Information of China (English)

    王佳; 胡明辅; 钟浩文

    2013-01-01

    管壳式热交换器具有一些其他热交换器无法比拟的优点,在过程工业中处于主导地位.随着计算机技术发展,计算机辅助设计逐渐取代了以往繁杂的人工设计计算.综述了近年来管壳式热交换器计算机辅助设计的研究进展,从国内、国外两方面介绍了最新的计算机辅助设计软件,并简要分析了管壳式热交换器计算机辅助设计发展中存在的一些问题.%Shell and tube heat exchanger play the leading role in process industry, because they have some advantages that others can't exceed. With the development of the computer, the computer aided design gradually replaced the multifarious conventional design. The research and development about computer aided design of shell and tube heat exchanger recently were summarized, and the newest computer aided software in both local and foreign was introduced. Some problems in the development about computer aided design of shell and tube heat exchanger were briefly analyzed.

  15. Spirocyclic ureas: orally bioavailable 11 beta-HSD1 inhibitors identified by computer-aided drug design.

    Science.gov (United States)

    Tice, Colin M; Zhao, Wei; Xu, Zhenrong; Cacatian, Salvacion T; Simpson, Robert D; Ye, Yuan-Jie; Singh, Suresh B; McKeever, Brian M; Lindblom, Peter; Guo, Joan; Krosky, Paula M; Kruk, Barbara A; Berbaum, Jennifer; Harrison, Richard K; Johnson, Judith J; Bukhtiyarov, Yuri; Panemangalore, Reshma; Scott, Boyd B; Zhao, Yi; Bruno, Joseph G; Zhuang, Linghang; McGeehan, Gerard M; He, Wei; Claremon, David A

    2010-02-01

    Structure-guided drug design led to the identification of a class of spirocyclic ureas which potently inhibit human 11beta-HSD1 in vitro. Lead compound 10j was shown to be orally bioavailable in three species, distributed into adipose tissue in the mouse, and its (R) isomer 10j2 was efficacious in a primate pharmacodynamic model.

  16. Designing an Orthotic Insole by Using Kinect® XBOX Gaming Sensor Scanner and Computer Aided Engineering Software

    Science.gov (United States)

    Hafiz Burhan, Mohd; Nor, Nik Hisyamudin Muhd; Yarwindran, Mogan; Ibrahim, Mustaffa; Fahrul Hassan, Mohd; Azwir Azlan, Mohd; Turan, Faiz Mohd; Johan, Kartina

    2017-08-01

    Healthcare and medical is one of the most expensive field in the modern world. In order to fulfil medical requirement, this study aimed to design an orthotic insole by using Kinect Xbox Gaming Sensor Scanner and CAE softwares. The accuracy of the Kinect® XBOX 360 gaming sensor is capable of producing 3D reconstructed geometry with the maximum and minimum error of 3.78% (2.78mm) and 1.74% (0.46mm) respectively. The orthotic insole design process had been done by using Autodesk Meshmixer 2.6 and Solidworks 2014 software. Functionality of the orthotic insole designed was capable of reducing foot pressure especially in the metatarsal area. Overall, the proposed method was proved to be highly potential in the design of the insole where it promises low cost, less time consuming, and efficiency in regards that the Kinect® XBOX 360 device promised low price compared to other digital 3D scanner since the software needed to run the device can be downloaded for free.

  17. Diseño de mecanismos de palancas asistido por computadora. // Computer Aided Design of lever mechanisms.

    Directory of Open Access Journals (Sweden)

    J. L. Betancourt Herrera

    2001-07-01

    Full Text Available En la práctica del diseño industrial hay múltiples problemas que requieren de la creación de un mecanismo concaracterísticas de movimiento peculiares. La elección de un método que permita la síntesis estructural, el planteamiento ysolución de las ecuaciones correspondientes, requeridas para el análisis cinemático de los mecanismos de palancas, en unaforma clara y simple, es un problema muy complejo de resolver en sentido general.Tomando como referencia la teoría para la formación de los grupos de Assur, el autor desarrolló el método de los gruposestructurales y sobre esta base el software DSM (Diseño y Simulación de Mecanismos, que es la herramienta de cómputopropuesta para apoyar al diseñador en el proceso de Diseño Cualitativo de Mecanismos de Palancas Asistido porComputadora, que consiste en un proceso iterativo entre síntesis y análisis con el que se pueden obtener los resultados de lavariación de la estructura de un mecanismo y de sus parámetros fundamentales, prácticamente en tiempo real.En el presente trabajo se definen y ejemplifican los conceptos y elementos principales relacionados con el diseñocualitativo de mecanismos de palancas asistido por computadora.Palabras claves: CAD, mecanismos de palancas, diseño industrial, análisis cinemático, síntesis estructural.___________________________________________________________________________AbstractThere are series of problems in industrial design practice that require a mechanism with specific characteristic movement.Selecting a method for achieving a clear and simple structural synthesis and cinematic analysis of lever mechanisms isgenerally understood as a hard-solving problem. Based on Assur´s Group Forming Theory, the author developed theStructural Groups Method and the DSM software (Design and Simulation of Mechanisms. This software is a tool intendedto help designers in the process of Computer Assisted Qualitative Design of Lever Mechanisms. It consists

  18. Computer aided engineering in exhaust aftertreatment systems design. Pt. 1. Spark ignition engine; Computergestuetzter Entwurf von Abgas-Nachbehandlungskonzepten. T. 1. Ottomotor

    Energy Technology Data Exchange (ETDEWEB)

    Stamatelos, A.M.; Koltsakis, G.C.; Kandylas, I.P. [Aristotelian Univ. of Thessaloniki (Greece)

    1999-02-01

    At the Aristotle University Thessaloniki, Greece, an integrated Computer Aided Engineering (CAE) methodology assisting the design of SI-engine exhaust aftertreatment systems employing the following computational tools was developed: A computer code which models transient exhaust system heat transfer, a tuneable computer code which models the transient operation of a three-way catalytic converter, a database containing chemical kinetics data for a variety of catalyst formulations, and a methodology for ageing assessment calculations. Application of the CAE methodology, which aids the exhaust aftertreatment system design engineer to meet the upcoming, increasingly stringent emission standards, is high-lighted by referring to a number of representative case studies. (orig.) [Deutsch] An der Aristoteles-Universitaet Thessaloniki, Griechenland, wurde eine computergestuetzte Methode (CAE) entwickelt, die den Entwurf und die Konstruktion von Abgasnachbehandlungskonzepten unterstuetzt. Die Methode setzt auf die folgenden Rechenmodelle und Datenbanken: Ein Rechenmodell zur Berechnung des Waermeuebergangs in Motorabgassystemen, ein Rechenmodell zur Abschaetzung des Katalysatorgegendrucks, eine Datenbank mit den chemischen Kinetikdaten fuer die verschiedenen Typen von Dreiwegekatalysatoren und eine computergestuetzte Prozedur zur Abschaetzung des Alterungsverhaltens von Dreiwegekatalysatoren. Integrierte CAE-Methoden koennen beim Entwurf von modernen Abgasnachbehandlungssystemen angewandt werden, um die Entwicklungszeit und -kosten betraechtlich zu reduzieren. (orig.)

  19. Computer Aided Battery Engineering Consortium

    Energy Technology Data Exchange (ETDEWEB)

    Pesaran, Ahmad

    2016-06-07

    A multi-national lab collaborative team was assembled that includes experts from academia and industry to enhance recently developed Computer-Aided Battery Engineering for Electric Drive Vehicles (CAEBAT)-II battery crush modeling tools and to develop microstructure models for electrode design - both computationally efficient. Task 1. The new Multi-Scale Multi-Domain model framework (GH-MSMD) provides 100x to 1,000x computation speed-up in battery electrochemical/thermal simulation while retaining modularity of particles and electrode-, cell-, and pack-level domains. The increased speed enables direct use of the full model in parameter identification. Task 2. Mechanical-electrochemical-thermal (MECT) models for mechanical abuse simulation were simultaneously coupled, enabling simultaneous modeling of electrochemical reactions during the short circuit, when necessary. The interactions between mechanical failure and battery cell performance were studied, and the flexibility of the model for various batteries structures and loading conditions was improved. Model validation is ongoing to compare with test data from Sandia National Laboratories. The ABDT tool was established in ANSYS. Task 3. Microstructural modeling was conducted to enhance next-generation electrode designs. This 3- year project will validate models for a variety of electrodes, complementing Advanced Battery Research programs. Prototype tools have been developed for electrochemical simulation and geometric reconstruction.

  20. Proceedings, A Workshop in Survivability and Computer-Aided Design, April 6-9, 1981, Fort Worth, Texas.

    Science.gov (United States)

    1981-01-01

    202-692-1730 Washington, D. C. 20361 AIR 5184J4 Arrighi , Joseph A. Fairchild-Republic 516-531-2637 Conklin Avenue Farmingdale, NY 11735 Avery, John G...Naval Air Development Center, Warminster, PA Joe Arrighi , Fairchild-Republic Pat Donnelly, Boeing Vertol Jerry Wallick, AF Aeronautical Systems...1963-A i _ . = . LA. I,,,- II- 0 , 0 LAJ 47 SURVIVABILITY/VULNERABILITY CONSIDERATIONS IN CONCEPTUAL DESIGN Joseph A. Arrighi Deputy Director of

  1. Computer-aided design for the Audi five-valve cylinder head concept; Rechnergestuetzte Auslegung des Audi-Fuenfventil-Zylinderkopfkonzeptes

    Energy Technology Data Exchange (ETDEWEB)

    Hannibal, W.; Lukas, F.

    1994-12-01

    Numerical methods are being used increasingly in the design of cylinder-head concepts when developing modern multi-valve automobile engine. The enclosed article illustrates calculations and methods used to design the Audi five-valve cylinder-head concept. At Audi, the necessary calculations are divided up according to their main emphasis and carried out decentrally by individual design and test departments. Complex numerical calculation procedures are developed in a central methods development department. By adopting technical calculation procedures at an early stage, development times in the cylinderhead concept phase can be reduced, risk factors assessed more accurately and costs cut. The technical calculations have had a considerable influence on the product quality of the cylinder heads. (orig.) [Deutsch] In der Entwicklung moderner Mehrventilmotoren fuer Pkw-Antriebe werden vermehrt numerische Methoden zur Auslegung des Zylinderkopfkonzeptes eingesetzt. Im vorliegenden Artikel werden Berechnungsumfaenge und Methoden dargestellt, die zur Auslegung des Audi-Fuenfventil-Zylinderkopfkonzeptes genutzt werden. Die Berechnung bei Audi werden schwerpunktmaessig dezentral in den einzelnen Konstruktions- und Versuchsabteilungen durchgefuehrt. Zusaetzlich werden in einer zentralen Abteilung fuer Methodenentwicklung aufwendige numerische Berechnungsverfahren entwickelt. Durch den fruehen Einsatz technischer Berechnungen koennen in der Konzeptphase der Entwicklung neuer Zylinderkoepfe Entwicklungszeiten verkuerzt, Risikofaktoren besser abgeschaetzt und Kosten verringert werden. Die technischen Berechnungen haben einen wesentlichen Einfluss auf die Produktqualitaet der Zylinderkoepfe gehabt. (orig.)

  2. DESIGN OF MANUAL MATERIAL HANDLING SYSTEM THROUGH COMPUTER AIDED ERGONOMICS: A CASE STUDY AT BDTSC TEXTILE FIRM

    Directory of Open Access Journals (Sweden)

    Amare Matebu

    2014-12-01

    Full Text Available Designing of lifting, pushing and pulling activities based on the physical and physiological capabilities of the operators is essential. The purpose of this study is to analyze manual material handling (MMH working posture of the operators using 3D Static Strength Prediction Program (3DSSPP software and to identify major areas causing long last injury of operators. The research has investigated the fit between the demands of tasks and the capabilities of operators. At the existing situations, the actual capabilities of operators have been computed with the help of 3DSSPP software and compared with NIOSH standards. Accordingly, operators' working posture is at an unacceptable position that exposes them for musculoskeletal disorders. Then, after the improvement of the design of MMH device (cart's roller, the result showed that the forces required by the operators to push and pull the sliver cans have been reduced from 931.77 Newton to 194.23 Newton. Furthermore, improvement of MMH cart's roller has reduced the awkward posture of operators and the risk of musculoskeletal disorders. The improved manual material handling design also saves about 1828.40 ETB per month for the company.

  3. The use and validation of a laser scanner for computer aided design and manufacturing of wheelchair seating.

    Science.gov (United States)

    Tasker, L H; Shapcott, N G; Holland, P M

    2011-01-01

    Professionals in wheelchair seating services over several decades have captured many thousands of patient shapes in various forms to manufacture customized seating systems for people with complex disabilities. With the exception of a few commercial companies, the predominant methodology employs a plaster casting technique to record the required shape. This can be labour-intensive and shape information is often retained in the cast and may not be recoverable over time due to storage issues. This paper describes the development of processes utilizing a laser scanner to advance the fabrication of customized seating systems. The study employed two 3D laser scanners and hence validated the use of the lower cost scanner (accuracy ± 0.1 mm) for both research purposes and clinical work. The paper concludes that these technologies have the potential to develop the knowledge of individuals' shapes with complex disabilities within specialist seating and other clinical fields.

  4. Implementing WebGL and HTML5 in Macromolecular Visualization and Modern Computer-Aided Drug Design.

    Science.gov (United States)

    Yuan, Shuguang; Chan, H C Stephen; Hu, Zhenquan

    2017-06-01

    Web browsers have long been recognized as potential platforms for remote macromolecule visualization. However, the difficulty in transferring large-scale data to clients and the lack of native support for hardware-accelerated applications in the local browser undermine the feasibility of such utilities. With the introduction of WebGL and HTML5 technologies in recent years, it is now possible to exploit the power of a graphics-processing unit (GPU) from a browser without any third-party plugin. Many new tools have been developed for biological molecule visualization and modern drug discovery. In contrast to traditional offline tools, real-time computing, interactive data analysis, and cross-platform analyses feature WebGL- and HTML5-based tools, facilitating biological research in a more efficient and user-friendly way. Copyright © 2017 Elsevier Ltd. All rights reserved.

  5. Project-Based Teaching-Learning Computer-Aided Engineering Tools

    Science.gov (United States)

    Simoes, J. A.; Relvas, C.; Moreira, R.

    2004-01-01

    Computer-aided design, computer-aided manufacturing, computer-aided analysis, reverse engineering and rapid prototyping are tools that play an important key role within product design. These are areas of technical knowledge that must be part of engineering and industrial design courses' curricula. This paper describes our teaching experience of…

  6. ICAM (Integrated Computer Aided Manufacturing) Conceptual Design for Computer-Integrated Manufacturing. Volume 1. Project Overview and Technical Summary

    Science.gov (United States)

    1984-06-29

    8217MJANUFACTURING e MANUFACTURING, WHICH BEGINS WITH PRODUCT DESIGN AND ENDS WITH SUPPORT AND MAINTENANCE IN THE FIELD, IS A MONOLITHIC , INDIV~SIBLE...UPON. KNOWLEDGE OF THEIR SURROUNDING ENVIRONMENT £\\NQ CONTRIBUTION OF THEIH JLJ\\IA. • ITJ EAM (M1 ANAGEMENT liJ ECHtJIQUES OFFER AN EXPLOSIVE IMPACT...DBMS SURVEYED: 1) RELAT tONAL 2) NETWORKING I I INFORMATION FORMAT: DBMS NAME: VENDOR: PRICE: HARDWARE: TYPE oF DBr ~s: HosT lANGUAGE: DATA

  7. Increasing Affinity of Interferon-γ Receptor 1 to Interferon-γ by Computer-Aided Design

    OpenAIRE

    2013-01-01

    We describe a computer-based protocol to design protein mutations increasing binding affinity between ligand and its receptor. The method was applied to mutate interferon-gamma receptor 1 (IFN-gamma-Rx) to increase its affinity to natural ligand IFN-gamma, protein important for innate immunity. We analyzed all four available crystal structures of the IFN-gamma-Rx/IFN-gamma complex to identify 40 receptor residues forming the interface with IFN-gamma. For these 40 residues, we performed comput...

  8. Potent new small-molecule inhibitor of botulinum neurotoxin serotype A endopeptidase developed by synthesis-based computer-aided molecular design.

    Directory of Open Access Journals (Sweden)

    Yuan-Ping Pang

    Full Text Available Botulinum neurotoxin serotype A (BoNTA causes a life-threatening neuroparalytic disease known as botulism. Current treatment for post exposure of BoNTA uses antibodies that are effective in neutralizing the extracellular toxin to prevent further intoxication but generally cannot rescue already intoxicated neurons. Effective small-molecule inhibitors of BoNTA endopeptidase (BoNTAe are desirable because such inhibitors potentially can neutralize the intracellular BoNTA and offer complementary treatment for botulism. Previously we reported a serotype-selective, small-molecule BoNTAe inhibitor with a K(i (app value of 3.8+/-0.8 microM. This inhibitor was developed by lead identification using virtual screening followed by computer-aided optimization of a lead with an IC(50 value of 100 microM. However, it was difficult to further improve the lead from micromolar to even high nanomolar potency due to the unusually large enzyme-substrate interface of BoNTAe. The enzyme-substrate interface area of 4,840 A(2 for BoNTAe is about four times larger than the typical protein-protein interface area of 750-1,500 A(2. Inhibitors must carry several functional groups to block the unusually large interface of BoNTAe, and syntheses of such inhibitors are therefore time-consuming and expensive. Herein we report the development of a serotype-selective, small-molecule, and competitive inhibitor of BoNTAe with a K(i value of 760+/-170 nM using synthesis-based computer-aided molecular design (SBCAMD. This new approach accounts the practicality and efficiency of inhibitor synthesis in addition to binding affinity and selectivity. We also report a three-dimensional model of BoNTAe in complex with the new inhibitor and the dynamics of the complex predicted by multiple molecular dynamics simulations, and discuss further structural optimization to achieve better in vivo efficacy in neutralizing BoNTA than those of our early micromolar leads. This work provides new insight

  9. Computer-Aided Design of Manufacturing Chain Based on Closed Die Forging for Hardly Deformable Cu-Based Alloys

    Science.gov (United States)

    Pietrzyk, Maciej; Kuziak, Roman; Pidvysots'kyy, Valeriy; Nowak, Jarosław; Węglarczyk, Stanisław; Drozdowski, Krzysztof

    2013-07-01

    Two copper-based alloys were considered, Cu-1 pct Cr and Cu-0.7 pct Cr-1 pct Si-2 pct Ni. The thermal, electrical, and mechanical properties of these alloys are given in the paper and compared to pure copper and steel. The role of aging and precipitation kinetics in hardening of the alloys is discussed based upon the developed model. Results of plastometric tests performed at various temperatures and various strain rates are presented. The effect of the initial microstructure on the flow stress was investigated. Rheologic models for the alloys were developed. A finite element (FE) model based on the Norton-Hoff visco-plastic flow rule was applied to the simulation of forging of the alloys. Analysis of the die wear for various processes of hot and cold forging is presented as well. A microstructure evolution model was implemented into the FE code, and the microstructure and mechanical properties of final products were predicted. Various variants of the manufacturing cycles were considered. These include different preheating schedules, hot forging, cold forging, and aging. All variants were simulated using the FE method and loads, die filling, tool wear, and mechanical properties of products were predicted. Three variants giving the best combination of forging parameters were selected and industrial trials were performed. The best manufacturing technology for the copper-based alloys is proposed.

  10. Recoding of the vesicular stomatitis virus L gene by computer-aided design provides a live, attenuated vaccine candidate.

    Science.gov (United States)

    Wang, Bingyin; Yang, Chen; Tekes, Gergely; Mueller, Steffen; Paul, Aniko; Whelan, Sean P J; Wimmer, Eckard

    2015-03-31

    Codon pair bias (CPB), which has been observed in all organisms, is a neglected genomic phenomenon that affects gene expression. CPB results from synonymous codons that are paired more or less frequently in ORFeomes regardless of codon bias. The effect of an individual codon pair change is usually small, but when it is amplified by large-scale genome recoding, strikingly altered biological phenotypes are observed. The utility of codon pair bias in the development of live attenuated vaccines was recently demonstrated by recodings of poliovirus (a positive-strand RNA virus) and influenza virus (a negative-strand segmented RNA virus). Here, the L gene of vesicular stomatitis virus (VSV), a nonsegmented negative-sense RNA virus, was partially recoded based on codon pair bias. Totals of 858 and 623 silent mutations were introduced into a 5'-terminal segment of the viral L gene (designated L1) to create sequences containing either overrepresented or underrepresented codon pairs, designated L1(sdmax) and L1(min), respectively. Analysis revealed that recombinant VSV containing the L1(min) sequence could not be recovered, whereas the virus with the sdmax sequence showed a modest level of attenuation in cell culture. More strikingly, in mice the L1(sdmax) virus was almost as immunogenic as the parental strain but highly attenuated. Taken together, these results open a new road to attain a balance between VSV virulence and immunogenicity, which could serve as an example for the attenuation of other negative-strand, nonsegmented RNA viruses. Vesicular stomatitis virus (VSV) is the prototypic rhabdovirus in the order Mononegavirales. A wide range of human pathogens belong to this family. Using a unique computer algorithm and large-scale genome synthesis, we attempted to develop a live attenuated vaccine strain for VSV, which could be used as an antigen delivery platform for humans. Recombinant VSVs with distinct codon pair biases were rationally designed, constructed, and

  11. Rapid Computer Aided Ligand Design and Screening of Precious Metal Extractants from TRUEX Raffinate with Experimental Validation

    Energy Technology Data Exchange (ETDEWEB)

    Clark, Aurora Sue [Washington State Univ., Pullman, WA (United States); Wall, Nathalie [Washington State Univ., Pullman, WA (United States); Benny, Paul [Washington State Univ., Pullman, WA (United States)

    2015-11-16

    through the design of a software program that uses state-of-the-art computational combinatorial chemistry, and is developed and validated with experimental data acquisition; the resulting tool allows for rapid design and screening of new ligands for the extraction of precious metals from SNF. This document describes the software that has been produced, ligands that have been designed, and fundamental new understandings of the extraction process of Rh(III) as a function of solution phase conditions (pH, nature of acid, etc.).

  12. Simulation of carbohydrate-protein interactions: Computer-aided design of a second generation GM1 mimic

    Science.gov (United States)

    Bernardi, Anna; Galgano, Marta; Belvisi, Laura; Colombo, Giorgio

    2001-02-01

    The oligosaccharide of ganglioside GM1 [Gal β1-3GalNAc β1-4(NeuAc α2-3)Gal β1-4Glc β1-1Cer] is the cellular target of two bacterial enterotoxins: the cholera toxin (CT) and the heat-labile toxin of E.coli (LT). We recently reported that the pseudosaccharide 2[Gal β1-3GalNAc β1-4(NeuAc α2-3)DCCHD] is a high-affinity ligand for CT, and thus a functional mimic of GM1 (Bernardi, A., Checchia, A., Brocca, P., Sonnino, S. and Zuccotto, F., J. Am. Chem. Soc., 121 (1999) 2032-2036). In this paper we describe the design of a second-generation mimic, formally obtained from 2 by inverting the configuration of a single stereocenter, thus transforming a N-acetyl galactosamine into a N-acetyl glucosamine. The design process involved modeling of the free ligand and its LT complex, followed by qualitative and quantitative comparison with the corresponding structures of 2. The protocol employed relied on both conformational search and molecular dynamics methodologies to account for the flexibility of both the ligand and the protein receptor. The conformational search of the LT:inhibitor complex showed that, compared to 2, the new compound can insert one more hydroxy group within the protein binding site. Molecular dynamics simulations showed that, in turn, this may trigger a series of rearrangements and reorientations of side chains and crystallographic water molecules in the toxin, leading to new H-bond contacts which may result in enhanced affinity of the new inhibitor. FEP calculations were performed by mutating the structure of 2 in solution and in the protein complex, and the prediction was made that the second-generation mimic should be a stronger binder than its parent compound.

  13. Computer-aided design of nanostructures from self- and directed-assembly of soft matter building blocks

    Science.gov (United States)

    Nguyen, Trung Dac

    2011-12-01

    Functional materials that are active at nanometer scales and adaptive to environment have been highly desirable for a huge array of novel applications ranging from photonics, sensing, fuel cells, smart materials to drug delivery and miniature robots. These bio-inspired features imply that the underlying structure of this type of materials should possess a well-defined ordering as well as the ability to reconfigure in response to a given external stimulus such as temperature, electric field, pH or light. In this thesis, we employ computer simulation as a design tool, demonstrating that various ordered and reconfigurable structures can be obtained from the self- and directed-assembly of soft matter nano-building blocks such as nanoparticles, polymer-tethered nanoparticles and colloidal particles. We show that, besides thermodynamic parameters, the self-assembly of these building blocks is governed by nanoparticle geometry, the number and attachment location of tethers, solvent selectivity, balance between attractive and repulsive forces, nanoparticle size polydispersity, and field strength. We demonstrate that higher-order nanostructures, i.e. those for which the correlation length is much greater than the length scale of individual assembling building blocks, can be hierarchically assembled. For instance, bilayer sheets formed by laterally tethered rods fold into spiral scrolls and helical structures, which are able to adopt different morphologies depending on the environmental condition. We find that a square grid structure formed by laterally tethered nanorods can be transformed into a bilayer sheet structure, and vice versa, upon shortening, or lengthening, the rod segments, respectively. From these inspiring results, we propose a general scheme by which shape-shifting particles are employed to induce the reconfiguration of pre-assembled structures. Finally, we investigate the role of an external field in assisting the formation of assembled structures that would

  14. SAR and Computer-Aided Drug Design Approaches in the Discovery of Peroxisome Proliferator-Activated Receptor γ Activators: A Perspective

    Directory of Open Access Journals (Sweden)

    Vaibhav A. Dixit

    2013-01-01

    Full Text Available Activators of PPARγ, Troglitazone (TGZ, Rosiglitazone (RGZ, and Pioglitazone (PGZ were introduced for treatment of Type 2 diabetes, but TGZ and RGZ have been withdrawn from the market along with other promising leads due cardiovascular side effects and hepatotoxicity. However, the continuously improving understanding of the structure/function of PPARγ and its interactions with potential ligands maintain the importance of PPARγ as an antidiabetic target. Extensive structure activity relationship (SAR studies have thus been performed on a variety of structural scaffolds by various research groups. Computer-aided drug discovery (CADD approaches have also played a vital role in the search and optimization of potential lead compounds. This paper focuses on these approaches adopted for the discovery of PPARγ ligands for the treatment of Type 2 diabetes. Key concepts employed during the discovery phase, classification based on agonistic character, applications of various QSAR, pharmacophore mapping, virtual screening, molecular docking, and molecular dynamics studies are highlighted. Molecular level analysis of the dynamic nature of ligand-receptor interaction is presented for the future design of ligands with better potency and safety profiles. Recently identified mechanism of inhibition of phosphorylation of PPARγ at SER273 by ligands is reviewed as a new strategy to identify novel drug candidates.

  15. Computer-aided design of multifrequency eddy-current tests for layered conductors with multiple property variations

    Energy Technology Data Exchange (ETDEWEB)

    Deeds, W E; Dodd, C V; Scott, G W

    1979-10-01

    Our program is part of a larger project designed to develop multifrequency eddy-current inspection techniques for multilayered conductors with parallel planar boundaries. To reduce the need to specially program each new problem, a family of programs that handle a large class of related problems with only minor editorial and interactive changes were developed. Programs for two types of cylindrical coil probes were developed: the reflection probe, which contains the driver and pickup coils and is used from one side of the specimen, and the through-transmission probe set, which places the driver and pickup coils on opposite sides of the conductor stack. The programs perform the following basic functions: (1) simulation of an ideal instrument's response to specific conductor and defect configurations, (2) control of an eddy-current instrument interfaced to a minicomputer to acquire and record actual instrument responses to test specimens, (3) construction of complex function expansions to relate instrument response to conductor and defect properties by using measured or computed responses and properties, and (4) simulation of a microcomputer on board the instrument by the interfaced minicomputer to test the analytical programming for the microcomputer. The report contains the basic equations for the computations, the main and subroutine programs, instructions for editorial changes and program execution, analyses of the main programs, file requirements, and other miscellaneous aids for the user.

  16. Increasing Affinity of Interferon-γ Receptor 1 to Interferon-γ by Computer-Aided Design

    Directory of Open Access Journals (Sweden)

    Pavel Mikulecký

    2013-01-01

    Full Text Available We describe a computer-based protocol to design protein mutations increasing binding affinity between ligand and its receptor. The method was applied to mutate interferon-γ receptor 1 (IFN-γ-Rx to increase its affinity to natural ligand IFN-γ, protein important for innate immunity. We analyzed all four available crystal structures of the IFN-γ-Rx/IFN-γ complex to identify 40 receptor residues forming the interface with IFN-γ. For these 40 residues, we performed computational mutation analysis by substituting each of the interface receptor residues by the remaining standard amino acids. The corresponding changes of the free energy were calculated by a protocol consisting of FoldX and molecular dynamics calculations. Based on the computed changes of the free energy and on sequence conservation criteria obtained by the analysis of 32 receptor sequences from 19 different species, we selected 14 receptor variants predicted to increase the receptor affinity to IFN-γ. These variants were expressed as recombinant proteins in Escherichia coli, and their affinities to IFN-γ were determined experimentally by surface plasmon resonance (SPR. The SPR measurements showed that the simple computational protocol succeeded in finding two receptor variants with affinity to IFN-γ increased about fivefold compared to the wild-type receptor.

  17. Novel Selenium-containing Human Single-chain Variable Fragment with Glutathione Peroxidase Activity from Computer-aided Molecular Design

    Institute of Scientific and Technical Information of China (English)

    WANG Cheng; MU Ying; L(U) Shao-wu; LUO Gui-min; WAN Pei; GONG Ping-sheng; L(U) Li-min; XU Ya-wei; ZHAO Yang; HE Bo; ZHAO Gang; YAN Gang-lin

    2011-01-01

    In order to enhance the glutathione peroxidase(GPX) catalytic activity of the selenium-containing single-chain variable fragments(Se-scFv),a novel human scFv was designed on the basis of the structure of human antibody and optimized via bioinformatics methods such as homologous sequence analysis,three-dimensional(3D)model building,binding-site analysis and docking.The DNA sequence of the new human scFv was synthesized and cloned into the expression vector pET22b(+),then the scFv protein was expressed in soluble form in Escherichia coli BL21(DE3) and purified by Ni2+-immobilized metal affinity chromatography(IMAC).The serine residue of scFv in the active site was converted into selenocysteine(Sec) with the chemical modification method,thus,the human Se-scFv with GPX activity was obtained.The GPX activity of the Se-scFv protein was characterized.Compared with other Se-scFv,the new human Se-scFv showed similar efficiency for catalyzing the reduction of hydrogen peroxide by glutathione.It exhibited pH and temperature dependent catalytic activity and a typical ping-pong kinetic mechanism.

  18. Development and Evaluation of a Computer-Aided Learning (CAL ...

    African Journals Online (AJOL)

    Development and Evaluation of a Computer-Aided Learning (CAL) Package on C++ ... Technology has created a great potential for borderless education. ... packages in the future, thus roviding additional resources for independent learning.

  19. Computer-Aided Modeling Framework

    DEFF Research Database (Denmark)

    Fedorova, Marina; Sin, Gürkan; Gani, Rafiqul

    development and application. The proposed work is a part of the project for development of methods and tools that will allow systematic generation, analysis and solution of models for various objectives. It will use the computer-aided modeling framework that is based on a modeling methodology, which combines....... In this contribution, the concept of template-based modeling is presented and application is highlighted for the specific case of catalytic membrane fixed bed models. The modeling template is integrated in a generic computer-aided modeling framework. Furthermore, modeling templates enable the idea of model reuse...... are generated through the template in ICAS-MoT and translated into a model object. Once in ICAS-MoT, the model is numerical analyzed, solved and identified. A computer-aided modeling framework integrating systematic model derivation and development tools has been developed. It includes features for model...

  20. Computer aided production engineering

    Energy Technology Data Exchange (ETDEWEB)

    1986-01-01

    This book presents the following contents: CIM in avionics; computer analysis of product designs for robot assembly; a simulation decision mould for manpower forecast and its application; development of flexible manufacturing system; advances in microcomputer applications in CAD/CAM; an automated interface between CAD and process planning; CAM and computer vision; low friction pneumatic actuators for accurate robot control; robot assembly of printed circuit boards; information systems design for computer integrated manufacture; and a CAD engineering language to aid manufacture.

  1. Computer Aided Design i England

    DEFF Research Database (Denmark)

    Sigrist, F.; Agger, K.; Barfoed, P.

    Meddelelsen redegør for en række besøg hos engelske systemleverandører og brugere. Seks forskellige CAD-systemer vurderes på baggrund af deres brug i praksis, og valget af to systemer til afprøvning i Danmark begrundes. Desuden bringes generelle konklusioner om CAD-systemernes aktuelle udviklings...

  2. Computer Aided Design i Danmark

    DEFF Research Database (Denmark)

    Sigrist, F.; Barfoed, P; Henriksen, L.

    Rapporten beskriver sidste fase i et projekt, som sigter mod at opbygge erfaringer om brug af CAD på danske tegnestuer. På en studietur valgte tre tegnestuer hver et CAD-system til afprøvning i fire måneder. Rapporten redegør for erfaringerne og belyser forholdet mellem dansk byggeri og datatekni...

  3. Computer Aided Design in England

    DEFF Research Database (Denmark)

    Grau, K.(red.); Sigrist, F.(red.)

    Meddelelsen, der er på engelsk, bringer i fortsættelse af SBI-meddelelse 41 redigerede uddrag af leverandørernes introduktionsmateriale til seks CAD-systemer. Materialet indeholder værdifulde redegørelser for systemernes principielle opbygning og deres praktiske funktion og ydeevne....

  4. Computer Aided Design i England

    DEFF Research Database (Denmark)

    Sigrist, F.; Agger, K.; Barfoed, P.

    Meddelelsen redegør for en række besøg hos engelske systemleverandører og brugere. Seks forskellige CAD-systemer vurderes på baggrund af deres brug i praksis, og valget af to systemer til afprøvning i Danmark begrundes. Desuden bringes generelle konklusioner om CAD-systemernes aktuelle udviklings...

  5. Computer Aided Design in England

    DEFF Research Database (Denmark)

    Grau, K.(red.); Sigrist, F.(red.)

    Meddelelsen, der er på engelsk, bringer i fortsættelse af SBI-meddelelse 41 redigerede uddrag af leverandørernes introduktionsmateriale til seks CAD-systemer. Materialet indeholder værdifulde redegørelser for systemernes principielle opbygning og deres praktiske funktion og ydeevne.......Meddelelsen, der er på engelsk, bringer i fortsættelse af SBI-meddelelse 41 redigerede uddrag af leverandørernes introduktionsmateriale til seks CAD-systemer. Materialet indeholder værdifulde redegørelser for systemernes principielle opbygning og deres praktiske funktion og ydeevne....

  6. Creating illusion in computer aided performance

    OpenAIRE

    Marshall, Joe

    2009-01-01

    This thesis studies the creation of illusion in computer aided performance. Illusion is created here by using deceptions, and a design framework is presented which suggests several different deception strategies which may be useful. The framework has been developed in an iterative process in tandem with the development of 3 real world performances which were used to explore deception strategies. The first case study presents a system for augmenting juggling performance. The techniques tha...

  7. Designing a novel dental root analogue implant using cone beam computed tomography and CAD/CAM technology

    NARCIS (Netherlands)

    Moin, D.A.; Hassan, B.; Mercelis, P.; Wismeijer, D.

    2013-01-01

    Objectives The study aim is to introduce a novel preemptively constructed dental root analogue implant (RAI) based on three-dimensional (3D) root surface models obtained from a cone beam computed tomography (CBCT) scan, computer aided designing and computer aided manufacturing technology. Materials

  8. Computer-aided translation tools

    DEFF Research Database (Denmark)

    Christensen, Tina Paulsen; Schjoldager, Anne

    2016-01-01

    The paper reports on a questionnaire survey from 2013 of the uptake and use of computer-aided translation (CAT) tools by Danish translation service providers (TSPs) and discusses how these tools appear to have impacted on the Danish translation industry. According to our results, the uptake in De...

  9. Effects of tributylborane-activated adhesive and two silane agents on bonding computer-aided design and manufacturing (CAD/CAM) resin composite.

    Science.gov (United States)

    Shinohara, Ayano; Taira, Yohsuke; Sawase, Takashi

    2017-01-09

    The present study was conducted to evaluate the effects of an experimental adhesive agent [methyl methacrylate-tributylborane liquid (MT)] and two adhesive agents containing silane on the bonding between a resin composite block of a computer-aided design and manufacturing (CAD/CAM) system and a light-curing resin composite veneering material. The surfaces of CAD/CAM resin composite specimens were ground with silicon-carbide paper, treated with phosphoric acid, and then primed with either one of the two silane agents [Scotchbond Universal Adhesive (SC) and GC Ceramic Primer II (GC)], no adhesive control (Cont), or one of three combinations (MT/SC, MT/GC, and MT/Cont). A light-curing resin composite was veneered on the primed CAD/CAM resin composite surface. The veneered specimens were subjected to thermocycling between 4 and 60 °C for 10,000 cycles, and the shear bond strengths were determined. All data were analyzed using analysis of variance and a post hoc Tukey-Kramer HSD test (α = 0.05, n = 8). MT/SC (38.7 MPa) exhibited the highest mean bond strengths, followed by MT/GC (30.4 MPa), SC (27.9 MPa), and MT/Cont (25.7 MPa), while Cont (12.9 MPa) and GC (12.3 MPa) resulted in the lowest bond strengths. The use of MT in conjunction with a silane agent significantly improved the bond strength. Surface treatment with appropriate adhesive agents was confirmed as a prerequisite for veneering CAD/CAM resin composite restorations.

  10. The comparison of BLyS-binding peptides from phage display library and computer-aided design on BLyS-TACI interaction.

    Science.gov (United States)

    Zhao, Yacong; Hao, Xiafei; Feng, Jiannan; Shen, Beifen; Wei, Jing; Sun, Jian

    2015-02-01

    BLyS antagonists have become the therapeutic reagents in the treatment of autoimmune disorders. BLyS binding peptides and their Fc fusion proteins may be alternative BLyS antagonists in such application. In this study, the activity of BLyS binding peptide 814 obtained from phage display library and peptide TA designed by computer-aided modeling on the interaction of BLyS-TACI was compared. In addition, to maintain the spatial conformation and stability of the peptides, human IgG1 Fc fragment was fused to peptides 814 and TA to form peptide-Fc fusion proteins, steady and innovative peptibodies. The prokaryotic expression plasmids pET30a-814-Fc and pET30a-TA-Fc for these peptibodies were acquired by genetic engineering, and confirmed by DNA sequencing. After the right plasmids were transformed into Escherichia coli BL21 (DE3), the fusion proteins were expressed and purified by protein A affinity column. As a result of competitive ELISA, peptides 814 and TA at 100μg/ml displayed 52.2% and 28.6% inhibition on the interaction of TACI-Fc with BLyS respectively. Moreover, 814-Fc and TA-Fc fusion proteins could bind to BLyS in a dosage-dependent manner as TACI-Fc did, and displayed 54.7% and 26.1% inhibition on the interaction of TACI-Fc-Myc with BLyS at 100μg/ml respectively. So 814-Fc and TA-Fc proteins had the similar bioactivity as the peptides did. Furthermore, compared with TA-Fc, 814-Fc showed two-fold inhibition effect on BLyS binding to TACI, suggesting that 814-Fc could inhibit BLyS bioactivity significantly and might serve as a potential antagonist to treat autoimmune diseases associated with BLyS overexpression.

  11. Research on the Construction of "Computer Aided De-sign" Platform Course Based on Design Majors%设计学类专业计算机辅助设计平台课建设研究

    Institute of Scientific and Technical Information of China (English)

    梁燕

    2014-01-01

    This paper provides a new idea for the course reform of"Computer Aided Design"for design majors. The construction of"Computer Aided Design"platform course for design majors is a complex and systematic project. After a systematic research and practice, a design plan for the construction is built. Platform course construction is of certain referential and enlightenment significance to the exploration on the professional course con-struction for design majors in common universities.%本文为设计学类专业计算机辅助设计课程改革提供了一个新的思路,建设设计学类专业计算机辅助设计平台课是一个复杂的系统工程,经过系统研究与实践,构建了平台课的设计方案。平台课的建设对于探索普通高等院校设计学科专业课程建设具有一定的借鉴与启发意义。

  12. Computer aided lexicography

    Science.gov (United States)

    Sklenář, Ivan; Kříž, Václav

    1990-11-01

    Programs with a natural-language user interface and text-processing programs require a vocabulary providing the mapping of the individual word form onto a lexeme, e.g. "says", "said", "saying"→"see". Examples of such programs are indexing programs for information retrieval, and spelling correctors for text-processing systems. The lexicographical task of such a computer vocabulary is especially difficult for Slavic languages, because their morphological structure is complex. An average Czech verb, for example, has 25 forms, and we have identified more than 100 paradigms for verbs. In order to support the creation of a Czech vocabulary, we have designed a system of programs for paradigm identification and derivation of words. The result of our effort is a vocabulary comprising 110 000 words and 1250 000 word forms. This vocabulary was used for the PASSAT system in the Czechoslovak Press Agency. This vocabulary may also be used in a spelling corrector. However, for such an application the vocabulary must be compressed into a compact form in order to shorten the access times. Compression is based on the paradigmatic structure of morphology which defines suffix sets for each word.

  13. Speech-enabled Computer-aided Translation

    DEFF Research Database (Denmark)

    Mesa-Lao, Bartolomé

    2014-01-01

    The present study has surveyed post-editor trainees’ views and attitudes before and after the introduction of speech technology as a front end to a computer-aided translation workbench. The aim of the survey was (i) to identify attitudes and perceptions among post-editor trainees before performing...... a post-editing task using automatic speech recognition (ASR); and (ii) to assess the degree to which post-editors’ attitudes and expectations to the use of speech technology changed after actually using it. The survey was based on two questionnaires: the first one administered before the participants...

  14. NALDA (Naval Aviation Logistics Data Analysis) CAI (computer aided instruction)

    Energy Technology Data Exchange (ETDEWEB)

    Handler, B.H. (Oak Ridge K-25 Site, TN (USA)); France, P.A.; Frey, S.C.; Gaubas, N.F.; Hyland, K.J.; Lindsey, A.M.; Manley, D.O. (Oak Ridge Associated Universities, Inc., TN (USA)); Hunnum, W.H. (North Carolina Univ., Chapel Hill, NC (USA)); Smith, D.L. (Memphis State Univ., TN (USA))

    1990-07-01

    Data Systems Engineering Organization (DSEO) personnel developed a prototype computer aided instruction CAI system for the Naval Aviation Logistics Data Analysis (NALDA) system. The objective of this project was to provide a CAI prototype that could be used as an enhancement to existing NALDA training. The CAI prototype project was performed in phases. The task undertaken in Phase I was to analyze the problem and the alternative solutions and to develop a set of recommendations on how best to proceed. The findings from Phase I are documented in Recommended CAI Approach for the NALDA System (Duncan et al., 1987). In Phase II, a structured design and specifications were developed, and a prototype CAI system was created. A report, NALDA CAI Prototype: Phase II Final Report, was written to record the findings and results of Phase II. NALDA CAI: Recommendations for an Advanced Instructional Model, is comprised of related papers encompassing research on computer aided instruction CAI, newly developing training technologies, instructional systems development, and an Advanced Instructional Model. These topics were selected because of their relevancy to the CAI needs of NALDA. These papers provide general background information on various aspects of CAI and give a broad overview of new technologies and their impact on the future design and development of training programs. The paper within have been index separately elsewhere.

  15. Review of research and development of computer-aided Kansei Engineering

    Institute of Scientific and Technical Information of China (English)

    Li LIN; Chengqi XUE

    2009-01-01

    Kansei Engineering is an important research approach and has become the hotspot of research in design fields. The concept of Kansei Engineering is introduced based on the investigation of related literatures. The working process and the key technology of computer-aided Kansei Engineering systems are discussed. Finally, the development trend of Kansei Engineering is outlined according to the development of computer and networking technology.

  16. Computer Aided Multi-scale Design of SiC-Si3N4 Nanoceramic Composites for High-Temperature Structural Applications

    Energy Technology Data Exchange (ETDEWEB)

    Vikas Tomer; John Renaud

    2010-08-31

    temperature dependent strength and microstructural stability was also significantly depended upon the dispersion of new phases at grain boundaries. The material design framework incorporates high temperature creep and mechanical strength data in order to develop a collaborative multiscale framework of morphology optimization. The work also incorporates a computer aided material design dataset development procedure where a systematic dataset on material properties and morphology correlation could be obtained depending upon a material processing scientist's requirements. Two different aspects covered under this requirement are: (1) performing morphology related analyses at the nanoscale and at the microscale to develop a multiscale material design and analyses capability; (2) linking material behavior analyses with the developed design tool to form a set of material design problems that illustrate the range of material design dataset development that could be performed. Overall, a software based methodology to design microstructure of particle based ceramic nanocomposites has been developed. This methodology has been shown to predict changes in phase morphologies required for achieving optimal balance of conflicting properties such as minimal creep strain rate and high fracture strength at high temperatures. The methodology incorporates complex material models including atomistic approaches. The methodology will be useful to design materials for high temperature applications including those of interest to DoE while significantly reducing cost of expensive experiments.

  17. Leadless Chip Carrier Packaging and CAD/CAM (Computer-Aided Design/Computer-Aided Manufacturing) Supported Wire Wrap Interconnect Technology for Subnanosecond ECL (Emitter Coupled Logic).

    Science.gov (United States)

    1982-12-01

    Operational Results The overall ring system clock rate is determined by the longest node-to-node wire pathway , which in this system is four feet. This length...Clock; 18.2 ns Period; 4 Foot Internode Separation; CERDI P Encapsulation) Node Input Register Ring Register Ring Data Signal OLoado Pulse "Clear* Pulse...NETWORK FABRICATED WITH SUBNANOSECOND ECL (55 MHz Clock; 18.2 ns Period; 4 Foot Internode Separation; CERDIP Encapsulation) Ring Data Signal: Differential

  18. Characterization of hydrophilic-rich phase mimic in dentin adhesive and computer-aided molecular design of water compatible visible light initiators

    Science.gov (United States)

    Abedin, Farhana

    infiltration of these noxious agents at the interface between the material and tooth could pave the way for enhanced degradation of the tooth structure (collagen and mineral) as well as the adhesive polymer. Novel photosensitizer molecules were proposed to improve the polymerization efficiency of this phase. Computer-aided molecular design (CAMD) was employed to obtain the new photosensitizers. These photosensitizers were capable of improving the degree of conversion of the hydrophilic-rich phase. An enhanced degree of conversion of the hydrophilic-rich phase would lead to a better seal at the adhesive/dentin interface and higher bond strength. Computer-aided molecular design (CAMD) is a fast and inexpensive technique compared to the conventional trial-and-error method to rationally design products. (Abstract shortened by ProQuest.).

  19. Computer-aided design of microfluidic very large scale integration (mVLSI) biochips design automation, testing, and design-for-testability

    CERN Document Server

    Hu, Kai; Ho, Tsung-Yi

    2017-01-01

    This book provides a comprehensive overview of flow-based, microfluidic VLSI. The authors describe and solve in a comprehensive and holistic manner practical challenges such as control synthesis, wash optimization, design for testability, and diagnosis of modern flow-based microfluidic biochips. They introduce practical solutions, based on rigorous optimization and formal models. The technical contributions presented in this book will not only shorten the product development cycle, but also accelerate the adoption and further development of modern flow-based microfluidic biochips, by facilitating the full exploitation of design complexities that are possible with current fabrication techniques. Offers the first practical problem formulation for automated control-layer design in flow-based microfluidic biochips and provides a systematic approach for solving this problem; Introduces a wash-optimization method for cross-contamination removal; Presents a design-for-testability (DfT) technique that can achieve 100...

  20. Advances in computer-aided engineering: CAD/CAM-research at Delft University of Technology. Report of the VF-project CAD/CAM 1989-1994

    NARCIS (Netherlands)

    1994-01-01

    This book contains a collection of articles describing on-going CAD/CAM-research at several engineering faculties at Delft University of Technology. Two main themes covered in this book are 'Conceptual design of complex products' and 'Product modelling and product data exchange'.

  1. Advances in computer-aided engineering: CAD/CAM-research at Delft University of Technology. Report of the VF-project CAD/CAM 1989-1994

    NARCIS (Netherlands)

    1994-01-01

    This book contains a collection of articles describing on-going CAD/CAM-research at several engineering faculties at Delft University of Technology. Two main themes covered in this book are 'Conceptual design of complex products' and 'Product modelling and product data exchange'.

  2. Computer-aided planning and surgical guiding system fabrication in premolar autotransplantation : a 12-month follow up

    NARCIS (Netherlands)

    van der Meer, Wicher Joerd; Jansma, Johan; Delli, Konstantina; Livas, Christos

    2016-01-01

    This case report describes the autotransplantation of maxillary right second premolar into the contralateral position in a 14-year-old female using computerized tomographic data and a customized guiding system produced by computer-aided design/computer-assisted manufacture technology. Using innovati

  3. Computer-aided planning and surgical guiding system fabrication in premolar autotransplantation : a 12-month follow up

    NARCIS (Netherlands)

    van der Meer, Wicher Joerd; Jansma, Johan; Delli, Konstantina; Livas, Christos

    2016-01-01

    This case report describes the autotransplantation of maxillary right second premolar into the contralateral position in a 14-year-old female using computerized tomographic data and a customized guiding system produced by computer-aided design/computer-assisted manufacture technology. Using innovati

  4. Computer-aided design/computer-aided manufacturing of zirconia all-ceramic crowns:stability and biocompatibility%计算机辅助设计与制造二氧化锆全瓷冠修复体:稳定性及生物相容性

    Institute of Scientific and Technical Information of China (English)

    李爽

    2015-01-01

    背景:二氧化锆全瓷冠修复以其优良的机械性能、生物相容性和美学性能在临床上受到欢迎和认可。目的:比较采用计算机辅助设计与计算机辅助及传统方法制作二氧化锆全瓷冠修复的临床效果。方法:纳入进行口腔全瓷冠修复患者87例,其中男56例,女31例,年龄21-56岁,其中42例采用计算机辅助设计与计算机辅助制作的二氧化锆全瓷冠进行修复,作为试验组;另45例采用传统方法制作的二氧化锆全瓷冠进行修复,作为对照组。修复6个月时,对比两组修复体表面质地、颜色匹配、解剖外形、边缘适合性、牙龈健康及患者满意度调查结果。结果与结论:试验组患者对修复后全瓷冠形态颜色的满意率达到100%,总体满意率达95%,显著好于对照组形态颜色满意率的78%及总体满意率的82%(P 0.05)。两组全瓷冠均无变色、崩瓷、裂纹及其他不良反应。说明通过计算机辅助设计与计算机辅助制作技术完成的氧化锆全瓷冠具有良好的美学效果、稳定性及生物相容性。%BACKGROUND:Zirconia al-ceramic crowns have been widely accepted in the clinic because of its excelent mechanical properties, biocompatibility and aesthetic performance. OBJECTIVE: To investigate the clinical efficacy of zirconia al-ceramic crowns prepared using computer-aided design/computer-aided manufacturingversusconventional method. METHODS:Eighty-seven patients who used zirconia al-ceramic crowns, consisting of 56 males and 31 females, aged 21-56 years were included in this study. Among these patients, 42 patients were subjected to tooth repair with zirconia al-ceramic crowns prepared using computer-aided design/computer-aided manufacturing technique (experimental group) and 45 patients received tooth repair with zirconia al-ceramic crowns prepared using conventional method (control group). At the end of the 6th month after zirconia al-ceramic crown

  5. Development of Computer Aided Design (PLRFCAD) System for Portal Lattice Frame%格构式门式钢框架结构计算机辅助设计系统开发

    Institute of Scientific and Technical Information of China (English)

    史波; 孙静; 姜峰

    2002-01-01

    针对格构式门式钢框架结构在工程实践中的应用状况,研制开发了PLRFCAD系统(Portal LatticeRigid Frame and Computer Aided Design system).介绍了系统的主要功能和结构,并对系统的前处理、结构计算、后处理等模块的设计及数据库设计进行了说明和分析.

  6. Mathematical modelling in the computer-aided process planning

    Science.gov (United States)

    Mitin, S.; Bochkarev, P.

    2016-04-01

    This paper presents new approaches to organization of manufacturing preparation and mathematical models related to development of the computer-aided multi product process planning (CAMPP) system. CAMPP system has some peculiarities compared to the existing computer-aided process planning (CAPP) systems: fully formalized developing of the machining operations; a capacity to create and to formalize the interrelationships among design, process planning and process implementation; procedures for consideration of the real manufacturing conditions. The paper describes the structure of the CAMPP system and shows the mathematical models and methods to formalize the design procedures.

  7. Unit cell-based computer-aided manufacturing system for tissue engineering.

    Science.gov (United States)

    Kang, Hyun-Wook; Park, Jeong Hun; Kang, Tae-Yun; Seol, Young-Joon; Cho, Dong-Woo

    2012-03-01

    Scaffolds play an important role in the regeneration of artificial tissues or organs. A scaffold is a porous structure with a micro-scale inner architecture in the range of several to several hundreds of micrometers. Therefore, computer-aided construction of scaffolds should provide sophisticated functionality for porous structure design and a tool path generation strategy that can achieve micro-scale architecture. In this study, a new unit cell-based computer-aided manufacturing (CAM) system was developed for the automated design and fabrication of a porous structure with micro-scale inner architecture that can be applied to composite tissue regeneration. The CAM system was developed by first defining a data structure for the computing process of a unit cell representing a single pore structure. Next, an algorithm and software were developed and applied to construct porous structures with a single or multiple pore design using solid freeform fabrication technology and a 3D tooth/spine computer-aided design model. We showed that this system is quite feasible for the design and fabrication of a scaffold for tissue engineering.

  8. Computer-Aided Training and Quality Assessment of Creative Abilities

    Directory of Open Access Journals (Sweden)

    V. P. Pechnikov

    2015-01-01

    Full Text Available The article describes the training program that takes into account the laws of human mental activity. The peculiarity of this training is that it enables specialists to generate additional intellectual potentials. This potentials relate to various kinds of illogical (intuitive and hybrid (human-machine intelligences that are associated with the quality of professional and creative activity in future. Progress in trans-phenomenal functional systems of the brain is possible by means of special procedures and computer-based training programs.The article offers a logical system of computer-aided training. This system repeatedly compares its input and output data and uses a feedback as the innate human characteristic to obtain the final result.Computer-aided training can be implemented in analog and numeric form. The article deals with the numeric widely used MS Excel-based software. It provides tabular and graphic style visualization desirable for training.A specific technical program is used for training. It allows specialists to develop a reinforcement shell of square cell type of minimal weight. In designing various constraints can be considered.On the main page of MS Excel program there are input data tables, various forms of the cell, methods of its manufacturing, and a scale table. Coefficients needed for calculations are in the next tables. The next tables contain also technological and design limitations. The basic table enables us to vary the geometric complexes of the reinforcement shell. Using the tabular and graphical results of calculations an operator can define values of further steps (iterations. The operator’s aim is to design the shell of minimum weight for the shortest time or number of steps. There is number of counters using macros in the MS Excel tables to calculate the number of past iterations.

  9. Computer-Aided Designing and Manufacturing of Lingual Fixed Orthodontic Appliance Using 2D/3D Registration Software and Rapid Prototyping

    Directory of Open Access Journals (Sweden)

    Soon-Yong Kwon

    2014-01-01

    Full Text Available The availability of 3D dental model scanning technology, combined with the ability to register CBCT data with digital models, has enabled the fabrication of orthognathic surgical CAD/CAM designed splints, customized brackets, and indirect bonding systems. In this study, custom lingual orthodontic appliances were virtually designed by merging 3D model images with lateral and posterior-anterior cephalograms. By exporting design information to 3D CAD software, we have produced a stereolithographic prototype and converted it into a cobalt-chrome alloy appliance as a way of combining traditional prosthetic investment and cast techniques. While the bonding procedure of the appliance could be reinforced, CAD technology simplified the fabrication process by eliminating the soldering phase. This report describes CAD/CAM fabrication of the complex anteroposterior lingual bonded retraction appliance for intrusive retraction of the maxillary anterior dentition. Furthermore, the CAD/CAM method eliminates the extra step of determining the lever arm on the lateral cephalograms and subsequent design modifications on the study model.

  10. Computer-Aided Designing and Manufacturing of Lingual Fixed Orthodontic Appliance Using 2D/3D Registration Software and Rapid Prototyping.

    Science.gov (United States)

    Kwon, Soon-Yong; Kim, Yong; Ahn, Hyo-Won; Kim, Ki-Beom; Chung, Kyu-Rhim; Kim Sunny, Seong-Hun

    2014-01-01

    The availability of 3D dental model scanning technology, combined with the ability to register CBCT data with digital models, has enabled the fabrication of orthognathic surgical CAD/CAM designed splints, customized brackets, and indirect bonding systems. In this study, custom lingual orthodontic appliances were virtually designed by merging 3D model images with lateral and posterior-anterior cephalograms. By exporting design information to 3D CAD software, we have produced a stereolithographic prototype and converted it into a cobalt-chrome alloy appliance as a way of combining traditional prosthetic investment and cast techniques. While the bonding procedure of the appliance could be reinforced, CAD technology simplified the fabrication process by eliminating the soldering phase. This report describes CAD/CAM fabrication of the complex anteroposterior lingual bonded retraction appliance for intrusive retraction of the maxillary anterior dentition. Furthermore, the CAD/CAM method eliminates the extra step of determining the lever arm on the lateral cephalograms and subsequent design modifications on the study model.

  11. Quality Indexing with Computer-Aided Lexicography.

    Science.gov (United States)

    Buchan, R. L.

    1992-01-01

    Discussion of computer-aided indexing activity focuses on examples from projects at the National Aeronautics and Space Administration (NASA). Standardization and quality in providing subject access to databases are considered; and computer-aided lexicography, including thesaurus construction, access vocabulary, definitions preparation,…

  12. ARCHITECTURE OF WEB BASED COMPUTER-AIDED MANUFACTURING SYSTEM

    Directory of Open Access Journals (Sweden)

    N. E. Filyukov

    2014-09-01

    Full Text Available The paper deals with design of a web-based system for Computer-Aided Manufacturing (CAM. Remote applications and databases located in the "private cloud" are proposed to be the basis of such system. The suggested approach contains: service - oriented architecture, using web applications and web services as modules, multi-agent technologies for implementation of information exchange functions between the components of the system and the usage of PDM - system for managing technology projects within the CAM. The proposed architecture involves CAM conversion into the corporate information system that will provide coordinated functioning of subsystems based on a common information space, as well as parallelize collective work on technology projects and be able to provide effective control of production planning. A system has been developed within this architecture which gives the possibility for a rather simple technological subsystems connect to the system and implementation of their interaction. The system makes it possible to produce CAM configuration for a particular company on the set of developed subsystems and databases specifying appropriate access rights for employees of the company. The proposed approach simplifies maintenance of software and information support for CAM subsystems due to their central location in the data center. The results can be used as a basis for CAM design and testing within the learning process for development and modernization of the system algorithms, and then can be tested in the extended enterprise.

  13. 计算机辅助设计与制作一体化玻璃纤维桩核修复漏斗状根管的抗疲劳和抗折性能%Fatigue and fracture resistance of the flared roots restored with computer aided design and computer aided manufacturing glass fiber posts

    Institute of Scientific and Technical Information of China (English)

    李智; 王新知; 高承志; IVO Krejci

    2013-01-01

    To evaluate the fatigue and fracture resistance of the flared roots restored with computer aided design (CAD) and computer aided manufacturing (CAM) glass fiber posts. Methods; In the study, 32 maxillary central incisors with roots longer than 13 mm were selected and their canals were flared, and the roots were allocated into 4 groups ( n = 8 ) by a random number chart: CAD/CAM glass fiber posts, prefabricated quartz fiber posts, cast gold alloy posts, and CAD/CAM zirconia posts. The posts were luted to the roots by resin cement and fabricate zirconia crown for every specimen. An addition-type silicone impression material was used to simulate the periodontal ligament. All the specimens were submitted to 1.2 X 106 cycles loaded with a 49 N force, at 45 degree to the long axis of the teeth simultaneously with 3 000 thermal cycles (5℃-50℃-5℃). After that, the specimens were subjected to a load at a crosshead speed of 1 mm/min in a servo-hydraulic testing machine applied at 45 degree to the long axis of the tooth until fracture. The data were subjected to ANOVA test and the patterns of the failure were examined. Results; After the cycling loading, 4 crowns from prefabricated quartz fiber posts groups were deboned, and no other failure was found after the cycling loading; the fracture strengths of CAD/CAM glass fiber posts group [ (441. 5 ± 103. 2) N] and cast gold alloy posts group [ (462. 9 ± 170.0) N] were higher (F=4.613, P<0.05) than those of CAD/CAM zirconia posts group [ (284.1 ± 99.0) N] and prefabricated quartz fiber posts group [(315. 4 ± 112. 3) N] ; the entire specimens presented unfavorable failures. Conclusion; Although further in vitro and in vivo studies are necessary,the results of this study show that the use of CAD/CAM glass fiber posts and cast gold alloy posts may a-chieve better outcomes in flared roots than that of CAD/CAM zirconia posts and prefabricated quartz fiber posts.%目的:评价计算机辅助设计与制作(computer aided

  14. Computer Aided Newspaper Content Analysis

    Science.gov (United States)

    1991-06-20

    Organization Organizational Concern 1. US. DOD A. U.S. commercial technology transfer 2. US. DOS B. U.S. defense technology transfer 3. U.S. DOC C. U.S... defense technology transfer (25); "C": software technology transfer (21); and "F": employment (20) are the three major concerns of the organizations

  15. Influence of coping material selection and porcelain firing on marginal and internal fit of computer-aided design/computer-aided manufacturing of zirconia and titanium ceramic implant-supported crowns%氧化锆和纯钛基底冠材料及饰瓷烧结对种植全冠适合性的影响

    Institute of Scientific and Technical Information of China (English)

    刘翠玲; 杨丽媛; 高旭; 商红

    2016-01-01

    Objective This study aimed to investigate the influence of coping material and porcelain firing on the marginal and internal fit of computer-aided design/computer-aided manufacturing (CAD/CAM) of zirconia ceramic implant- and titanium ceramic implant-supported crowns. Methods Zirconia ceramic implant (group A, n=8) and titanium metal ceramic implantsupported crowns (group B, n=8) were produced from copings using the CAD/CAM system. The marginal and internal gaps of the copings and crowns were measured by using a light-body silicone replica technique combined with micro-computed tomog-raphy scanning to obtain a three-dimensional image. Marginal gap (MG), horizontal marginal discrepancy (HMD), and axial wall (AW) were measured. Statistical analyses were performed using SPSS 17.0. Results Prior to porcelain firing, the measurements for MG, HMD, and AW of copings in group A were significantly larger than those in group B (P0.05). Porcelain firing significantly reduced MG (P0.05). Conclusion The marginal fits of CAD/CAM zirconia ceramic implant-supported crowns were superior to those of CAD/CAM titanium ceramic-supported crowns. The fits of both the CAD/CAM zirconia ceramic implant- and titanium ceramic implant-supported crowns were obviously influenced by porcelain firing.%目的:研究氧化锆和纯钛基底冠材料及饰瓷烧结对种植全冠内部和边缘适合性的影响。方法制作计算机辅助设计/计算机辅助制作(CAD/CAM)氧化锆烤瓷种植全冠(A组)和纯钛烤瓷种植全冠(B组)各8个(n=8)。分别用硅橡胶轻体复制饰瓷烧结前基底冠和饰瓷烧结后全冠的内部和边缘间隙,采用Micro-CT扫描硅橡胶,建立三维图像,测量冠边缘垂直间隙(MG)、冠边缘水平间隙(HMD)和冠内部轴面中点间隙(AW)。采用SPSS 17.0软件对测量结果进行统计学分析。结果饰瓷烧结前,A组基底冠MG、HMD和AW均大于B组(P0.05)。

  16. Computer-aided decision making.

    Science.gov (United States)

    Keith M. Reynolds; Daniel L. Schmoldt

    2006-01-01

    Several major classes of software technologies have been used in decisionmaking for forest management applications over the past few decades. These computer-based technologies include mathematical programming, expert systems, network models, multi-criteria decisionmaking, and integrated systems. Each technology possesses unique advantages and disadvantages, and has...

  17. Computer-aided approach for customized cell-based defect reconstruction.

    Science.gov (United States)

    Meyer, Ulrich; Neunzehn, Jörg; Wiesmann, Hans Peter

    2012-01-01

    Computer-aided technologies like computer-aided design (CAD), computer-aided manufacturing (CAM), and a lot of other features like finite element method (FEM) have been recently employed for use in medical ways like in extracorporeal bone tissue engineering strategies. Aim of this pilot experimental study was to test whether autologous osteoblast-like cells cultured in vitro on individualized scaffolds can be used to support bone regeneration in a clinical environment. Mandibular bone defects were surgically introduced into the mandibles of Göttinger minipigs and the scaffold of the defect site was modelled by CAD/CAM techniques. From the minipigs harvested autologous bone cells from the porcine calvaria were cultivated in bioreactors. The cultured osteoblast-like cells were seeded on polylactic acid/polyglycolic acid (PLA/PGA) copolymer scaffolds being generated by rapid prototyping. The bone defects were then reconstructed by implanting these tissue-constructs into bone defects. The postoperative computerized topographic scans as well as the intraoperative sites demonstrated the accurate fit in the defect sites. The individual created, implanted scaffold constructs enriched with the porcine osteoblast-like cells were well tolerated and appeared to support bone formation, as revealed by immunohistochemical and histological analyses. The results of this investigations indicated that the in vitro expanded osteoblast-like cells spread on a resorbable individualized, computer-aided fabricated scaffold is capable of promoting the repair of bone tissue defects in vivo. The shown results warrant further attempts to combine computer modelling and tissue engineering for use in different ways in bone reconstructive surgery.

  18. T形焊缝超声相控阵检测的计算机辅助技术%Computer-Aided Technology of Ultrasonic Phased Array Inspection for T-Weld

    Institute of Scientific and Technical Information of China (English)

    陆铭慧; 程俊; 张颖

    2012-01-01

    超声相控阵技术在T形焊缝中的应用表现出其明显优势,但声波在T形焊缝中的辐射区域不能形象界定,且回波来源的位置得不到准确地判断.针对T形焊缝的结构编译了超声相控阵检测辅助软件,对试样中的人工孔检测表明:采用计算机辅助技术可以实现T形焊缝超声相控阵扇扫声束覆盖及回波信号的识别.%The application of the ultrasonic phased array technology on T-weld shows its obvious advantages. However, the beam areas of T-weld still can not be defined, and can not estimate the position of the echo. According to the structure of the T-weld, the ultrasonic phased array inspection support software is compiled. Artificial sample tests suggests that the computer-aided technology could achieve the beam coverage of T-welded and help to distinguish the echo signal.

  19. 计算机辅助设计与制造系统用于大腿假肢远程加工的效果%Application of Computer Aided Design/Computer Aided Manufacturing System for Tele-process of Lower-limb Prosthesis

    Institute of Scientific and Technical Information of China (English)

    周大伟; 吴磊; 吴锡汉

    2015-01-01

    Objective To explore the feasibility of professional computer-aided design prosthetic software and processing systems for tele-process of lower-limb prosthesis. Methods The residual limb size data of 8 leg-amputation patients in prosthetic clinical reception were transferred to the computer prosthetic processing center. The appropriate lower-limb prosthetic socket mouth circles were selected in the soft-ware data model library, and were modified in accordance with the size table, and then they were processed and sent to the prosthetic clinical reception for the patients. The clinical function of lower-limb prosthesis was evaluated after try-on. Results The clinical function met the re-quirements in 7 patients wearing the prosthesis. Conclusion It is possible to design and tele-process lower-limb prosthesis through elaborate dimensional measurement, which can be a mode to serve lower-limb prosthesis to remote areas.%目的:探索使用专业假肢计算机辅助设计软件和制作系统进行远程制作大腿假肢的可行性。方法通过互联网,将异地假肢临床接待室的8例大腿截肢患者残肢尺寸数据传送到计算机假肢制作加工中心,利用软件数据模型库选择相应的大腿假肢接受腔口型圈并按照尺寸表进行数据模型修改,将修改后的数据模型进行实体模型加工并送至假肢临床接待室给患者适配假肢。给患者试穿假肢后按照大腿假肢临床功能评估进行评价。结果7例患者大腿假肢临床功能评估达到要求。结论通过严谨的残肢尺寸测量并进行计算机设计和远程加工的模式是可行的。该模式可解决偏远地区大腿截肢患者无法制作假肢的问题。

  20. Computer-Aided Detection and diagnosis for prostate cancer based on mono and multi-parametric MRI: a review.

    Science.gov (United States)

    Lemaître, Guillaume; Martí, Robert; Freixenet, Jordi; Vilanova, Joan C; Walker, Paul M; Meriaudeau, Fabrice

    2015-05-01

    Prostate cancer is the second most diagnosed cancer of men all over the world. In the last few decades, new imaging techniques based on Magnetic Resonance Imaging (MRI) have been developed to improve diagnosis. In practise, diagnosis can be affected by multiple factors such as observer variability and visibility and complexity of the lesions. In this regard, computer-aided detection and computer-aided diagnosis systems have been designed to help radiologists in their clinical practice. Research on computer-aided systems specifically focused for prostate cancer is a young technology and has been part of a dynamic field of research for the last 10 years. This survey aims to provide a comprehensive review of the state-of-the-art in this lapse of time, focusing on the different stages composing the work-flow of a computer-aided system. We also provide a comparison between studies and a discussion about the potential avenues for future research. In addition, this paper presents a new public online dataset which is made available to the research community with the aim of providing a common evaluation framework to overcome some of the current limitations identified in this survey.

  1. A computer-aided continuous assessment system

    Directory of Open Access Journals (Sweden)

    B. C.H. Turton

    1996-12-01

    Full Text Available Universities within the United Kingdom have had to cope with a massive expansion in undergraduate student numbers over the last five years (Committee of Scottish University Principals, 1993; CVCP Briefing Note, 1994. In addition, there has been a move towards modularization and a closer monitoring of a student's progress throughout the year. Since the price/performance ratio of computer systems has continued to improve, Computer- Assisted Learning (CAL has become an attractive option. (Fry, 1990; Benford et al, 1994; Laurillard et al, 1994. To this end, the Universities Funding Council (UFQ has funded the Teaching and Learning Technology Programme (TLTP. However universities also have a duty to assess as well as to teach. This paper describes a Computer-Aided Assessment (CAA system capable of assisting in grading students and providing feedback. In this particular case, a continuously assessed course (Low-Level Languages of over 100 students is considered. Typically, three man-days are required to mark one assessed piece of coursework from the students in this class. Any feedback on how the questions were dealt with by the student are of necessity brief. Most of the feedback is provided in a tutorial session that covers the pitfalls encountered by the majority of the students.

  2. CMOS analog integrated circuit design technology; CMOS anarogu IC sekkei gijutsu

    Energy Technology Data Exchange (ETDEWEB)

    Fujimoto, H.; Fujisawa, A. [Fuji Electric Co. Ltd., Tokyo (Japan)

    2000-08-10

    In the field of the LSI (large scale integrated circuit) in rapid progress toward high integration and advanced functions, CAD (computer-aided design) technology has become indispensable to LSI development within a short period. Fuji Electric has developed design technologies and automatic design system to develop high-quality analog ICs (integrated circuits), including power supply ICs. within a short period. This paper describes CMOS (complementary metal-oxide semiconductor) analog macro cell, circuit simulation, automatic routing, and backannotation technologies. (author)

  3. Planeación asistida por computadora del proceso tecnológico de ensamble. //Computer-aided gliding of the assembles technological process.

    Directory of Open Access Journals (Sweden)

    L. L. Tomás García

    2008-01-01

    Full Text Available El presente trabajo está dedicado a la optimización bajo criterios múltiples de la planificación de procesos de ensamblemecánico a partir de su modelo geométrico tridimensional. Se soporta sobre un enfoque que integra tanto informacióngeométrica como restricciones tecnológicas del proceso de ensamble. En el desarrollo de la misma quedó demostrado, queuna vez conocido el modelo geométrico tridimensional de un ensamble, la aplicación de criterios tecnológicos ygeométricos al proceso inverso de desensamble y su posterior tratamiento con métodos evolutivos, genera planes deensamble mecánico próximos a los óptimos de acuerdo al sistema de preferencias del decisor. La integración de lainformación permite disminuir el número de secuencias a evaluar y de elementos a procesar, con lo que se evita lageneración y evaluación de todas las secuencias posibles con la consecuente disminución del tiempo de procesamiento.Como resultado de la aplicación del modelo integrado propuesto, se obtiene la planificación del proceso de ensamblemecánico con una reducción del tiempo de ensamble debido a que en las secuencias obtenidas se reduce el número decambios de dirección de ensamble, los cambios de herramientas y de puestos de trabajo, así como se minimiza la distanciaa recorrer debido al cambio de puestos de trabajo. Esto se logra mediante un modelo de optimización multiobjetivo basadoen algoritmos genéticos.Palabras claves: Ensamble mecánico, algoritmos genéticos, optimización multiobjetivo.______________________________________________________________________________Abstract:This work deals with the combinatorial problem of generating and optimizing technologically feasible assembly sequencesand process planning involving tools and work places. The assembly sequences and related technological decisions areobtained from a 3D model of the assembled parts based on mating conditions along with a set of technological criteria

  4. Evaluation of Computer-Aided System Design Tools for SDI (Strategic Defense Initiative) Battle Management/C3 (Command, Control and Communications) Architecture Development

    Science.gov (United States)

    1987-10-01

    Ft. Meade, MD 20755-6000 Lee Cooper 1 copy Advanced Technology 2121 Crystal Drive, Suite 200 Arlington, VA 22202 Larry Cox I copy TRW 1950 Sunwest...Richmond Street Providence, RI 02903 " - Mr. Larry Christina, Jr. 1 copy Technology Branch, CSSD-H-SBY Battle Management Division U.S. Army Strategic...copy ’_ Advanced System Architectures Johnson House 73-79 Park Street GU 15 3PE, United Kingdom s. - .%° N. % S CSED Review Panel Dr. Dan Alpert

  5. Computer Aided Software Engineering workstation evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Kotcher, D.A.; Parish, R.B.; Sisson, A.M.; Wenzel, W.A.; Wiancko, B.E.

    1988-09-14

    This report presents an evaluation of interconnected high performance workstations. The evaluation specifically addresses the benefits to personnel engaged in Computer Aided Software Engineering (CASE) for the design and development of computer software aided by computer workstations. To narrow the scope of the CASE evaluation to a reasonable size, the class of workstations considered was limited to units having the following minimum capabilities: speed to issue 2 to 3 million instructions per second (Mips), 4 megabytes (MB) of central memory, 140 MB of local disk storage, a monitor with 1024 by 960 graphics resolution, and Ethernet compatibility. In addition, software requirements included a virtual memory implementation of the UNIX operating system, the defacto standard networking Transmission Control Protocol and Internet Protocol (TCP/IP), and the network file system (NFS). Support of selected third-party software, such as the TEMPLATE graphics software, and robust tools for software development were also required. These criteria are justified by the use of workstations for maintenance and support of large mainframe based FORTRAN computer programs. The evaluation concluded that workstations are excellent tools for CASE. 1 ref., 1 fig., 6 tabs.

  6. Preliminary evaluation of clinical effect of computer aided design and computer aided manufacture zirconia crown%计算机辅助设计与辅助制作氧化锆全瓷冠的临床效果初探

    Institute of Scientific and Technical Information of China (English)

    王宇光; 邢燕西; 孙玉春; 赵一姣; 吕培军; 王勇

    2013-01-01

    Objective To evaluate clinical effects of computer aided design and computer aided manufacturing (CAD/CAM) milled zirconia crown in three aspects:aesthetic,contact wear and fracture.Methods Sixty patients were devided into two groups.In one group,35 full contour CAD/CAM zirconia crown were made on molars of 30 patients.The manufacturing process of zirconia crown was as follow.First,the three dimensional(3-D) data of working models,antagonist impression and check records were acquired by 3-D laser scanning Dentalwings S50.Then full contour zirconia crowns,which had functional occlusal contacts with antagonistic teeth,and appropriate contact with adjacent teeth were designed with Zeno-CAD (V4.2.5.5.12919) software.ZENOSTAR Zr pure zirconia material was milled in digital controlled machine WIELAND 4030 M1.In the end,the zirconia crown were completed with the method of second sintering and polishing.After clinical try-in,the crown was cemented.In the control group,thirty gold alloy full crown were made and cemented on molars of 30 patients.According to the modified U S Public Health Service Criteria(USPHS) evaluation standard,all crowns were evaluated on the same day,at three months,half a year,one year and two years following delivery.There were three aspects we were focusing on in the evaluation:aesthetic,contact wear (restoration and antagonist),and fracture.Results In all the prosthesis we evaluated during the 24 months,no fracture was found.Contact wear of crowns varies according to different antagonist teeth.Conclusions The zirconia crowns show privilege in aesthesis,toughness and anti-wearing.However,there is contact wear on antagonistic natural teeth.Thus it is a good choice when full zirconia crowns are indicated on two antagonistic teeth in both jaws.%目的 评价计算机辅助设计与辅助制作氧化锆全瓷冠的临床修复效果,为其临床应用提供参考.方法 选择于北京大学口腔医学院·口腔医院修复科就

  7. Analysis and Simulation of Cutting Process of Agricultural Robot-Based on Computer Aided Design%农业机器人切削过程仿真分析-基于计算机辅助设计

    Institute of Scientific and Technical Information of China (English)

    王珂; 王桂凤

    2017-01-01

    As for the 6 freedom degrees robot machining platform , it discusses the data chain structure of the robot and computer aided design tools , and research on the motion control process and optimize the design result .Through it intro-duces the machining control the whole structure of the system , to construct the robot kinematics model , then according to the computer aided design tool , the transformation of the coordinates of the robot the subsequent optimization process , each joint forward and inverse kinematics calculation and robot motion control program generation process is studied .This paper has carried on the system simulation software ADAMS , and completed the processing of 3D samples.The test re-sults show that the system can automatically generate a processing instruction robot motion control program , direct drive robot end effect or tool movement , produce the parts , high feasibility .%利用6自由度机器人切削加工平台,讨论了该机器人与计算机辅助设计工具的数据链结构,研究了其运动控制过程,并对设计结果进行有效优化。通过介绍切削加工控制系统整体结构,构建了机器人运动学模型,并根据计算机辅助设计工具,对机器人后续优化过程的坐标转换、各关节正逆运动学计算以及机器人运动控制程序生成过程进行了深入研究。同时,对系统进行了ADAMS软件仿真,并完成了3 D样件的加工。试验结果表明:该系统可以自动生成机器人运动控制程序的加工指令,直接驱动机器人末端执行刀具的运动,实现零部件的加工生产,可行性高。

  8. 肩台不同抛光方法对计算机辅助设计与辅助制作氧化锆全冠边缘密合性的影响%The influence of the different polishing methods on the marginal sealing property of the computer aided design and computer aided manufacture zirconium dioxide full crown

    Institute of Scientific and Technical Information of China (English)

    周建营; 邓久鹏; 李金源; 王继德; 沈宝莲

    2016-01-01

    better than ordinary shoulder treatment.%目的 评价不同抛光方法对计算机辅助设计与辅助制作(computer aided design and computer aided manufacture,CAD/CAM)氧化锆全冠边缘密合性的影响,为临床提供参考.方法 选取30颗离体前磨牙,应用简单随机方法分成A、B、C组,每组10颗,3组离体牙用MANI TF-13车针进行牙体预备.A组肩台不处理;B组用MANI TR 13-EF车针抛光肩台;C组用KaVo SONICflex气动超声手机抛光肩台.每组选取5颗预备后样本牙,共制作15个CAD/CAM氧化锆全冠.使用树脂水门汀粘接,指甲油封闭牙根,流动树脂封闭根尖孔.将试件置于3%亚甲基兰中24 h,体视显微镜观察肩台边缘微渗漏状况,进行分级评估.每组剩余样本牙用于粗糙度检测和扫描电镜观察.结果 微渗漏程度C组最小,B组次之,A组最大(x2=44.610,P<0.001),组间差异均有统计学意义(P<0.05).C组表面粗糙度[(0.27±0.03) μm]显著小于A、B组(P<0.05).扫描电镜可见C组肩台的纹理以360°向四周扩散,较A、B两组更平滑.结论 气动超声手机精修肩台的抗微渗漏能力优于常规肩台处理方式.

  9. An Integrated Computer-Aided Approach for Environmental Studies

    DEFF Research Database (Denmark)

    Gani, Rafiqul; Chen, Fei; Jaksland, Cecilia;

    1997-01-01

    A general framework for an integrated computer-aided approach to solve process design, control, and environmental problems simultaneously is presented. Physicochemical properties and their relationships to the molecular structure play an important role in the proposed integrated approach. The scope...... and applicability of the integrated approach is highlighted through examples involving estimation of properties and environmental pollution prevention. The importance of mixture effects on some environmentally important properties is also demonstrated....

  10. Some new algorithms for computer aided assembly planning

    OpenAIRE

    Kunica, Zoran; Vranješ, Božo; Hrman, Miljenko

    2015-01-01

    The paper depicts some of the improved and newly implemented algorithms of the computer aided design (CAD) based system for the plan generation of automatic assembly (GPAS), relating to definitions of assembly sequence and paths, space structuring (layout) of the assembly process for bench assembly product orientation, connectivity, and treatment of identical parts in a product. In the approach, the parts of which are presented in the paper, the mechanical product to be assembled is, initiall...

  11. Computer-Aided Modelling Methods and Tools

    DEFF Research Database (Denmark)

    Cameron, Ian; Gani, Rafiqul

    2011-01-01

    The development of models for a range of applications requires methods and tools. In many cases a reference model is required that allows the generation of application specific models that are fit for purpose. There are a range of computer aided modelling tools available that help to define...... a taxonomy of aspects around conservation, constraints and constitutive relations. Aspects of the ICAS-MoT toolbox are given to illustrate the functionality of a computer aided modelling tool, which incorporates an interface to MS Excel....

  12. Computer Aided Modelling – Opportunities and Challenges

    DEFF Research Database (Denmark)

    2011-01-01

    This chapter considers the opportunities that are present in developing, extending and applying aspects of computer-aided modelling principles and practice. What are the best tasks to be done by modellers and what needs the application of CAPE tools? How do we efficiently develop model-based solu......This chapter considers the opportunities that are present in developing, extending and applying aspects of computer-aided modelling principles and practice. What are the best tasks to be done by modellers and what needs the application of CAPE tools? How do we efficiently develop model...

  13. Computer-Aided Framework for the Design of Freeze-Drying Cycles: Optimization of the Operating Conditions of the Primary Drying Stage

    Directory of Open Access Journals (Sweden)

    Davide Fissore

    2015-05-01

    Full Text Available This paper deals with the freeze-drying process and, in particular, with the optimization of the operating conditions of the primary drying stage. When designing a freeze-drying cycle, process control aims at obtaining the values of the operating conditions (temperature of the heating fluid and pressure in the drying chamber resulting in a product temperature lower than the limit value of the product, and in the shortest drying time. This is particularly challenging, mainly due to the intrinsic nonlinearity of the system. In this framework, deep process knowledge is required for deriving a suitable process dynamic model that can be used to calculate the design space for the primary drying stage. The design space can then be used to properly design (and optimize the process, preserving product quality. The case of a product whose dried layer resistance, one of the key model parameters, is affected by the operating conditions is addressed in this paper, and a simple and effective method to calculate the design space in this case is presented and discussed.

  14. [Computer-aided method and rapid prototyping for the personalized fabrication of a silicone bandage digital prosthesis].

    Science.gov (United States)

    Ventura Ferreira, Nuno; Leal, Nuno; Correia Sá, Inês; Reis, Ana; Marques, Marisa

    2014-01-01

    The fabrication of digital prostheses has acquired growing importance not only for the possibility for the patient to overcome psychosocial trauma but also to promote grip functionality. An application method of three dimensional-computer-aided design technologies for the production of passive prostheses is presented by means of a fifth finger amputee clinical case following bilateral hand replantation.Three-dimensional-computerized tomography was used for the collection of anthropometric images of the hands. Computer-aided design techniques were used to develop the digital file-based prosthesis from the reconstruction images by inversion and superimposing the contra-lateral finger images. The rapid prototyping manufacturing method was used for the production of a silicone bandage prosthesis prototype. This approach replaces the traditional manual method by a virtual method that is basis for the optimization of a high speed, accurate and innovative process.

  15. Electromagnetic tracking for abdominal interventions in computer aided surgery.

    Science.gov (United States)

    Zhang, Hui; Banovac, Filip; Lin, Ralph; Glossop, Neil; Wood, Bradford J; Lindisch, David; Levy, Elliot; Cleary, Kevin

    2006-05-01

    Electromagnetic tracking has great potential for assisting physicians in precision placement of instruments during minimally invasive interventions in the abdomen, since electromagnetic tracking is not limited by the line-of-sight restrictions of optical tracking. A new generation of electromagnetic tracking has recently become available, with sensors small enough to be included in the tips of instruments. To fully exploit the potential of this technology, our research group has been developing a computer aided, image-guided system that uses electromagnetic tracking for visualization of the internal anatomy during abdominal interventions. As registration is a critical component in developing an accurate image-guided system, we present three registration techniques: 1) enhanced paired-point registration (time-stamp match registration and dynamic registration); 2) orientation-based registration; and 3) needle shape-based registration. Respiration compensation is another important issue, particularly in the abdomen, where respiratory motion can make precise targeting difficult. To address this problem, we propose reference tracking and affine transformation methods. Finally, we present our prototype navigation system, which integrates the registration, segmentation, path-planning and navigation functions to provide real-time image guidance in the clinical environment. The methods presented here have been tested with a respiratory phantom specially designed by our group and in swine animal studies under approved protocols. Based on these tests, we conclude that our system can provide quick and accurate localization of tracked instruments in abdominal interventions, and that it offers a user-friendly display for the physician.

  16. [Computer-aided electronic prescribing in Spanish hospitals].

    Science.gov (United States)

    Rubio Fernández, M; Aldaz Francés, R; García Gómez, C; Valladolid Walsh, A

    2005-01-01

    To describe electronic prescribing in a sample of Spanish hospitals and activities derived from its implementation in Hospital Pharmacy Departments, software features and acceptance. A survey that included data related to program implantation and performance in hospitals with diverse characteristics was designed. It was posted at the Sociedad Española de Farmacia Hospitalaria website for a 6-month period and completed by phone. A total of 47 hospitals answered the survey. 13 (27.7%) had electronic prescribing systems, and of these, 8 of them had more than 75% of beds included in the system. In 15 (31.9%) hospitals that did not have it, its implementation was in project in the near future. Software applications used in this new health technology were not homogeneous, while integration of applications that facilitate Pharmaceutical Care tasks was infrequent. In 61.5% of the hospitals with electronic prescribing, transcription used to be the pharmacist s task. In 92.3% of these hospitals, order validation is currently carried out by pharmacists. The degree of satisfaction with the system was rated as good or very good by 92.3% of pharmacists. Computer-aided electronic prescribing appears to be a helpful tool for restructuring Department organization and investing time in new activities. A more ambitious and effective approach to clinical activities will therefore be possible. System optimization requires taking into account factors such as worker time investment, since new activities will be developed, along with the need for training courses.

  17. Computer Aided Grid Interface: An Interactive CFD Pre-Processor

    Science.gov (United States)

    Soni, Bharat K.

    1997-01-01

    NASA maintains an applications oriented computational fluid dynamics (CFD) efforts complementary to and in support of the aerodynamic-propulsion design and test activities. This is especially true at NASA/MSFC where the goal is to advance and optimize present and future liquid-fueled rocket engines. Numerical grid generation plays a significant role in the fluid flow simulations utilizing CFD. An overall goal of the current project was to develop a geometry-grid generation tool that will help engineers, scientists and CFD practitioners to analyze design problems involving complex geometries in a timely fashion. This goal is accomplished by developing the CAGI: Computer Aided Grid Interface system. The CAGI system is developed by integrating CAD/CAM (Computer Aided Design/Computer Aided Manufacturing) geometric system output and/or Initial Graphics Exchange Specification (IGES) files (including all the NASA-IGES entities), geometry manipulations and generations associated with grid constructions, and robust grid generation methodologies. This report describes the development process of the CAGI system.

  18. An Efficient Framework For Fast Computer Aided Design of Microwave Circuits Based on the Higher-Order 3D Finite-Element Method

    Directory of Open Access Journals (Sweden)

    A. Lamecki

    2014-12-01

    Full Text Available In this paper, an efficient computational framework for the full-wave design by optimization of complex microwave passive devices, such as antennas, filters, and multiplexers, is described. The framework consists of a computational engine, a 3D object modeler, and a graphical user interface. The computational engine, which is based on a finite element method with curvilinear higher-order tetrahedral elements, is coupled with built-in or external gradient-based optimization procedures. For speed, a model order reduction technique is used and the gradient computation is achieved by perturbation with geometry deformation, processed on the level of the individual mesh nodes. To maximize performance, the framework is targeted to multicore CPU architectures and its extended version can also use multiple GPUs. To illustrate the accuracy and high efficiency of the framework, we provide examples of simulations of a dielectric resonator antenna and full-wave design by optimization of two diplexers involving tens of unknowns, and show that the design can be completed within the duration of a few simulations using industry-standard FEM solvers. The accuracy of the design is confirmed by measurements.

  19. Computer Aided Optimization Design of Riveted Joints in Aeronautics%计算机辅助飞机铆钉连接优化设计

    Institute of Scientific and Technical Information of China (English)

    高原; 于随然

    2014-01-01

    飞机铆钉连接设计涉及设计部门与计算部门,部门之间的数据交流过程不仅浪费大量时间,而且也会因为配合不协调导致数据版本等出现错误。为了优化飞机铆钉连接设计流程,文章提出了一种结合两个部门功能并利用设计者自身知识的计算机辅助设计方法,其核心是一个能够从多方面综合评价铆钉连接设计的算法以及一个友善的用户界面。将方法应用于SaM146涡轮发动机机舱铆钉连接设计,验证了其有效性。%Riveted joints design includes the design department and the calculation department. During the transmission of information between the two departments, a lot of time is wasted and it can easily lead to desynchroni-zation between departments. To optimize the design process of riveted joints in aeronautics, a method was brought out to solve this problem by combining the functions of these two departments and, at the same time, taking advantage of the designers’ expertise. The key elements of this method were a friendly user interface and an algorithm which can e-valuate riveted joints design from several aspects. Finally this method is applied to a riveted joints design in the na-celle of SaM146 turbofan engine and thus proves this method is both effective and efficient.

  20. 集成电路版图CAD课程实践教学的研究%Research on practice teaching mode of computer aided design of IC layout course

    Institute of Scientific and Technical Information of China (English)

    施敏; 张振娟; 黄静; 朱友华; 张威

    2014-01-01

    探讨集成电路版图CAD课程实践教学模式,围绕“一个规则、两个流程、四个问题”这条主线和两种相辅相成的实验教学模式进行实验内容设计和实验实施,以课外科技竞赛为抓手,改革课程设计环节,注重培养综合能力,在实践中取得了良好的效果,显著提高了实践教学质量。%In this paper, the practice teaching mode of Computer Aided Design of IC layout course is discussed. According to one trunk line and two related course experiments mode, the experiment contents and methods were designed and implemented. Meanwhile, other efforts including emphasis of extracurricular scientiifc competition and reform of course practicum, were adopted to pay attention to the cultivation of comprehensive ability for students. The practice teaching mode proved that better teaching effect have been obtained.

  1. 3D volume assessment techniques and computer-aided design and manufacturing for preoperative fabrication of implants in head and neck reconstruction.

    Science.gov (United States)

    Patel, Ashish; Otterburn, David; Saadeh, Pierre; Levine, Jamie; Hirsch, David L

    2011-11-01

    Cases in subdisciplines of craniomaxillofacial surgery--corrective jaw surgery, maxillofacial trauma, temporomandibular joint/skull base, jaw reconstruction, and postablative reconstruction-illustrate the ease of use, cost effectiveness, and superior results that can be achieved when using computer-assisted design and 3D volumetric analysis in preoperative surgical planning. This article discusses the materials and methods needed to plan cases, illustrates implementation of guides and implants, and describes postoperative analysis in relation to the virtually planned surgery.

  2. 板式换热器可视化计算机辅助设计系统的研制%The Development of a Visualized Computer-aided Design System for Plate Heat Exchangers

    Institute of Scientific and Technical Information of China (English)

    董超俊

    2001-01-01

    板式换热器是一种结构紧凑型的高效换热器,其换热及流动特性非常复杂,作者在Windows 95平台上,综合利用Visual Basic、Autocad及Turbo C等软件开发了板式换热器可视化计算机辅助设计系统。利用该系统,使用者只需输入几个参数,系统便能自动完成从设计计算到绘图的全过程。系统界面友好,使用方便,实用性强。%Plate heat exchangers represent a kind of highly compact and efficient heat exchange device. As such heat exchangers feature an extremely complicated heat exchange and flow characteristics, there still lacks, to date, a unified formula for calculating their heat transfer and resistance. At present they are designed and calculated mainly by relying on manual work. However, a manual design and calculation process often suffers from both a high complexity and an extreme inaccuracy. With the comprehensive utilization of such a variety of software as Visual Basic, AutoCad and Turbo C, etc the author has on the platform of Windows 95 developed a visualized computer-aided design system. Through the use of that system a designer only needs to input some relevant parameters and the system will automatically complete the whole process starting from the design and calculation and ending with the completion of all design drawings. The system has a user-friendly interface and can be conveniently used in practical design work

  3. 基于先进制造平台的假肢接受腔计算机辅助制造系统%Computer-aided prosthetic socket manufacturing system based on an advanced manufacture technology

    Institute of Scientific and Technical Information of China (English)

    杨鹏; 陈玲玲; 李松; 宣伯凯

    2009-01-01

    OBJECTIVE:To overcome the shortcoming of manual method,computer-aided manufacturing (CAM) system of prosthetic socket is applied to improve socket's quality and processing efficiency,which also reduces the demand of operator's knowledge and experience.METHODS:Prosthetic socket CAM system was discussed based on an advanced manufacture technology,and the hardware and software were designed.The advanced manufacture platform was composed of an industrial personal computer (IPC),a motion control card,four sets of Panasonic digital AC servo control system,four lead screw guides,two spindle motor of milling cutter,a transducer,two switching power supply,limit switch and proximity switch.The software of prosthetic socket CAM system mainly included three function modules:parameter setting,machine testing and beginning processing.Through adjusting command pulse's input and driver's coefficient,the motor worked at different speeds.RESULTS:The result of experiment demonstrated that maximum rotational speed restriction was applied to protect the motor,and the motor could work very smoothly without vibration in very low speed.It was suitable for manufacture prosthetic sockets,and could manufacture the high quality prosthetic socket to satisfy the requirements of amputee.CONCLUSION:Prosthetic socket CAM system based on the advanced manufacture platform can overcome the shortcoming of traditional manual method,ensure product quality,and reduce the cost.The protracted experience of certified prosthetist was incorporated into the design program to reduce the demand of manipulator's knowledge and experience,increase the one-time success rate of manufacture prosthetic sockets,and improve the quality uncertainty of sockets.It can change the backward production mode of designing,measuring,taking model,and modifying model which depends on handwork.%目的:为了克服手工制作假肢接受腔的缺点,将计算机辅助制造技术用于加工假肢接受腔,提高接受腔的质量

  4. Computer-Aided Medical Diagnosis. Literature Review

    Science.gov (United States)

    1978-12-15

    BOUCKAERT, A., Computer-aided diagnosis of goitres in a cancer department, Int. J. Bio-’Med. Comput., 3 (1972) p. 3. BOYLE, J. A., GREIG, W. R., FRANKLIN, D...toxic goitre , Q. J. Med., 35 (1966) p. 565. Bricetti, A. B. and Bleich, H. L., A computer program that evaluates patients with hypercalcemia, J

  5. Computer-Aided Corrosion Program Management

    Science.gov (United States)

    MacDowell, Louis

    2010-01-01

    This viewgraph presentation reviews Computer-Aided Corrosion Program Management at John F. Kennedy Space Center. The contents include: 1) Corrosion at the Kennedy Space Center (KSC); 2) Requirements and Objectives; 3) Program Description, Background and History; 4) Approach and Implementation; 5) Challenges; 6) Lessons Learned; 7) Successes and Benefits; and 8) Summary and Conclusions.

  6. Effect of type of practice in a computer-aided design environment in visualizing three-dimensional objects from two-dimensional orthographic projections.

    Science.gov (United States)

    Duesbury, R T; O'Neil, H F

    1996-06-01

    The purpose of this study was to determine the effect of practice in manipulating 2- and 3-dimensional (D) wireframe images on a learner's ability to visualize 3-D objects. Practice, either rotational or not, consisted of visualizing 2- and 3-D objects generated by personal computer (PC)-based computer-assisted design software. Results indicated that participants in the rotation treatment group performed significantly better than those in either the nonrotation or control group on measures of spatial ability and 3-D visualization ability. Both treatment groups performed significantly better than the control group on measures of metacognition, effort, and worry. These results support a conclusion that spatial ability can be improved through practice that allows the learner to see the relationship between the 2-D and 3-D features of objects.

  7. Engineering a more thermostable blue light photo receptor Bacillus subtilis YtvA LOV domain by a computer aided rational design method.

    Directory of Open Access Journals (Sweden)

    Xiangfei Song

    Full Text Available The ability to design thermostable proteins offers enormous potential for the development of novel protein bioreagents. In this work, a combined computational and experimental method was developed to increase the T m of the flavin mononucleotide based fluorescent protein Bacillus Subtilis YtvA LOV domain by 31 Celsius, thus extending its applicability in thermophilic systems. Briefly, the method includes five steps, the single mutant computer screening to identify thermostable mutant candidates, the experimental evaluation to confirm the positive selections, the computational redesign around the thermostable mutation regions, the experimental reevaluation and finally the multiple mutations combination. The adopted method is simple and effective, can be applied to other important proteins where other methods have difficulties, and therefore provides a new tool to improve protein thermostability.

  8. Computer aided engineering in exhaust aftertreatment sytems design. Part 2: Diesel engines; Computergestuetzter Entwurf von Abgas-Nachbehandlungskonzepten. Teil 2: Dieselmotoren

    Energy Technology Data Exchange (ETDEWEB)

    Stamatelos, A.M.; Koltsakis, G.C.; Kandylas, I.P. [Aristoteles Univ., Thessaloniki (Greece)

    1999-03-01

    In the field of diesel engines, there is growing interest in CAE methods for low-emission concepts, as newly developed mathematical models become more and more efficient. The design of diesel exhaust systems must take three general concepts into account: the oxidation catalyst, the particulate filter and the DeNO{sub x} catalyst. A CAE methodology developed at the Aristotle University in Thessaloniki, Greece, to aid engineers in designing exhaust systems is presented in this paper. The methodology is based on the following computational tools: a transient exhaust system heat transfer code, a transient oxidation and DeNO{sub x} catalytic converter code, a catalyst kinetics database for the various types of oxidation and DeNO{sub x} catalytic converters and a computational tool for calculating the loading and regeneration of diesel filters with and without catalytic support. (orig.) [Deutsch] Im Bereich der Dieselmotoren nimmt das Interesse an computergestuetzten CAE-Methoden fuer Niedrigemissionskonzepte zu, da neu entwickelte mathematische Modelle immer leistungsfaehiger werden. Der Entwurf von Dieselabgassystemen muss drei allgemeine Konzepte beruecksichtigen: Oxidationskatalysator, Partikelfilter und DeNO{sub x}-Katalysator. Eine an der Aristoteles Universitaet Thessaloniki, Griechenland, entwickelte computergestuetzte Methode, die den Entwurf von Abgassystemen unterstuetzten kann, wird im Folgenden dargestellt. Die Methode basiert auf folgenden Rechenmodellen: ein Modell zur Berechnung des Waermeuebergangs im Abgassystem, ein Rechenmodell zur Bestimmung des Instationaerverhaltens des Oxidations- und des DeNO{sub x}-Katalysators, eine Datenbank mit den chemischen Kinetikdaten fuer die verschiedenen Typen von Oxidations- und DeNO{sub x}-Katalysatoren sowie ein Rechenmodell zur Berechnung der Beladung und Regenerierung von Dieselfiltern mit oder ohne katalytische Unterstuetzung. (orig.)

  9. Computer-Aided Design of Orally Bioavailable Pyrrolidine Carboxamide Inhibitors of Enoyl-Acyl Carrier Protein Reductase of Mycobacterium tuberculosis with Favorable Pharmacokinetic Profiles

    Science.gov (United States)

    Kouassi, Affiba Florance; Kone, Mawa; Keita, Melalie; Esmel, Akori; Megnassan, Eugene; N’Guessan, Yao Thomas; Frecer, Vladimir; Miertus, Stanislav

    2015-01-01

    We have carried out a computational structure-based design of new potent pyrrolidine carboxamide (PCAMs) inhibitors of enoyl-acyl carrier protein reductase (InhA) of Mycobacterium tuberculosis (MTb). Three-dimensional (3D) models of InhA-PCAMx complexes were prepared by in situ modification of the crystal structure of InhA-PCAM1 (Protein Data Bank (PDB) entry code: 4U0J), the reference compound of a training set of 20 PCAMs with known experimental inhibitory potencies (IC50exp). First, we built a gas phase quantitative structure-activity relationships (QSAR) model, linearly correlating the computed enthalpy of the InhA-PCAM complex formation and the IC50exp. Further, taking into account the solvent effect and loss of inhibitor entropy upon enzyme binding led to a QSAR model with a superior linear correlation between computed Gibbs free energies (ΔΔGcom) of InhA-PCAM complex formation and IC50exp (pIC50exp = −0.1552·ΔΔGcom + 5.0448, R2 = 0.94), which was further validated with a 3D-QSAR pharmacophore model generation (PH4). Structural information from the models guided us in designing of a virtual combinatorial library (VL) of more than 17 million PCAMs. The VL was adsorption, distribution, metabolism and excretion (ADME) focused and reduced down to 1.6 million drug like orally bioavailable analogues and PH4 in silico screened to identify new potent PCAMs with predicted IC50pre reaching up to 5 nM. Combining molecular modeling and PH4 in silico screening of the VL resulted in the proposed novel potent antituberculotic agent candidates with favorable pharmacokinetic profiles. PMID:26703572

  10. Computer-Aided Design of Orally Bioavailable Pyrrolidine Carboxamide Inhibitors of Enoyl-Acyl Carrier Protein Reductase of Mycobacterium tuberculosis with Favorable Pharmacokinetic Profiles

    Directory of Open Access Journals (Sweden)

    Affiba Florance Kouassi

    2015-12-01

    Full Text Available We have carried out a computational structure-based design of new potent pyrrolidine carboxamide (PCAMs inhibitors of enoyl-acyl carrier protein reductase (InhA of Mycobacterium tuberculosis (MTb. Three-dimensional (3D models of InhA-PCAMx complexes were prepared by in situ modification of the crystal structure of InhA-PCAM1 (Protein Data Bank (PDB entry code: 4U0J, the reference compound of a training set of 20 PCAMs with known experimental inhibitory potencies (IC50exp. First, we built a gas phase quantitative structure-activity relationships (QSAR model, linearly correlating the computed enthalpy of the InhA-PCAM complex formation and the IC50exp. Further, taking into account the solvent effect and loss of inhibitor entropy upon enzyme binding led to a QSAR model with a superior linear correlation between computed Gibbs free energies (ΔΔGcom of InhA-PCAM complex formation and IC50exp (pIC50exp = −0.1552·ΔΔGcom + 5.0448, R2 = 0.94, which was further validated with a 3D-QSAR pharmacophore model generation (PH4. Structural information from the models guided us in designing of a virtual combinatorial library (VL of more than 17 million PCAMs. The VL was adsorption, distribution, metabolism and excretion (ADME focused and reduced down to 1.6 million drug like orally bioavailable analogues and PH4 in silico screened to identify new potent PCAMs with predicted IC50pre reaching up to 5 nM. Combining molecular modeling and PH4 in silico screening of the VL resulted in the proposed novel potent antituberculotic agent candidates with favorable pharmacokinetic profiles.

  11. Evaluation of computer-aided detection and diagnosis systems.

    Science.gov (United States)

    Petrick, Nicholas; Sahiner, Berkman; Armato, Samuel G; Bert, Alberto; Correale, Loredana; Delsanto, Silvia; Freedman, Matthew T; Fryd, David; Gur, David; Hadjiiski, Lubomir; Huo, Zhimin; Jiang, Yulei; Morra, Lia; Paquerault, Sophie; Raykar, Vikas; Samuelson, Frank; Summers, Ronald M; Tourassi, Georgia; Yoshida, Hiroyuki; Zheng, Bin; Zhou, Chuan; Chan, Heang-Ping

    2013-08-01

    Computer-aided detection and diagnosis (CAD) systems are increasingly being used as an aid by clinicians for detection and interpretation of diseases. Computer-aided detection systems mark regions of an image that may reveal specific abnormalities and are used to alert clinicians to these regions during image interpretation. Computer-aided diagnosis systems provide an assessment of a disease using image-based information alone or in combination with other relevant diagnostic data and are used by clinicians as a decision support in developing their diagnoses. While CAD systems are commercially available, standardized approaches for evaluating and reporting their performance have not yet been fully formalized in the literature or in a standardization effort. This deficiency has led to difficulty in the comparison of CAD devices and in understanding how the reported performance might translate into clinical practice. To address these important issues, the American Association of Physicists in Medicine (AAPM) formed the Computer Aided Detection in Diagnostic Imaging Subcommittee (CADSC), in part, to develop recommendations on approaches for assessing CAD system performance. The purpose of this paper is to convey the opinions of the AAPM CADSC members and to stimulate the development of consensus approaches and "best practices" for evaluating CAD systems. Both the assessment of a standalone CAD system and the evaluation of the impact of CAD on end-users are discussed. It is hoped that awareness of these important evaluation elements and the CADSC recommendations will lead to further development of structured guidelines for CAD performance assessment. Proper assessment of CAD system performance is expected to increase the understanding of a CAD system's effectiveness and limitations, which is expected to stimulate further research and development efforts on CAD technologies, reduce problems due to improper use, and eventually improve the utility and efficacy of CAD in

  12. 园林计算机辅助设计工学结合课程开发初探%Development of Computer-Aided Landscape Design Program: A Work-Integrated Learning Approach

    Institute of Scientific and Technical Information of China (English)

    刘和平; 林剑波

    2011-01-01

    为培养学生职业能力,提高学生借助计算机绘制园林设计图的能力,笔者探讨了《园林计算机辅助设计》工学结合课程开发.课程开发小组在分析学生学情和园林专业典型工作任务的基础上,围绕课程开发原则,以一个典型的园林项目为载体,将知识内容紧密结合在工作过程中讲授,并制定学习要求,采用项目任务等新的考核方式来综合评价学生的学习质量.%A work-integrated learning approach to the program, Computer-Aided Landscape Design, is put forward to improve their skills in landscape sketch drawing. After an analysis of students' potentials and typical tasks of landscape majors, the program development team conducts a work-integrated learning approach, in which the traditional theory-oriented testing is replaced by a task-driven assessment to evaluate their performance in class.

  13. 基于VLisp开发车站信号计算机联锁辅助设计程序%Secondary Development of Computer-aided Design Program Base on VLisp for Railway Station Signal Computer-based Interlocking

    Institute of Scientific and Technical Information of China (English)

    邓伟龙

    2014-01-01

    In view of the difficulty in preparing the drawings of railway station signal computer-based interlocking at present, a computer-aided design program base on VLisp was developed in this paper. This paper analyzed the system architecture of this program, and also analyzed the keystones of this program, such as how to satisfy the need of supporting a variety of interlocking systems, and how to combine with the coding softwares. Finally, this paper put forward an effective solution, and suggested the improvement direction of this program. It can be seen that the application of this program has greatly facilitated the users and improved the production efficiency.%针对目前完成计算机联锁图纸存在的困难,基于VLisp开发计算机辅助设计软件。分析该软件的系统结构,分析系统需要支持多种联锁制式、与电码化软件结合等难点,提供了有效的解决方案,同时提出了系统的改进方向。 CBICAD的应用,大大方便了用户,提高了生产效率。

  14. Computer Aided Rapid Design for Switch Ark Layout in the PDM%PDM环境下的计算机辅助开关柜快速排布设计

    Institute of Scientific and Technical Information of China (English)

    胡敏; 石教英

    2001-01-01

    Most of the switch ark manufactures produce according to individual customer needs. In order to meet highly competitive needs of today's market, a new way of computer aided rapid design for switch ark in the PDM environment is proposed. The establishment of basic data and the modes of switch ark layout are described. The interface between PDM and AutoCAD is presented. In addition, an example of switch ark layout in the PDM is presented.%开关柜制造企业大都国绕客户特定需求定制生产,传统的产品设计模式越来越不适合快速发展的市场需求,针对开关柜行业的产品设计特点,提出在PDM环境下进行开关柜计算机辅助快速设计思想,着重介绍了开关柜设计中基础数据的建设、开关柜排布模式以及PDM与AutoCAD信息集成接口的设计,最后给出了具体的开关柜设计实例.

  15. 基于MFC的机车交路图辅助设计系统研究%Development of Computer-aided Design System of Locomotive Routing Mapping Based on MFC

    Institute of Scientific and Technical Information of China (English)

    李鸣; 倪智振

    2013-01-01

    In order to adapt to the new environment of railway locomotive servicing and maintenance development,and to improve the efficiency of locomotive routing mapping,a computer-aided design system of locomotive routing mapping for Win7 circumstance was studied and developed by means of development tool Visual Studio 2010,based on Microsoft Foundation Classes (MFC),and implemented by object-oriented C++program language.This system have many advantages:good compatibility,being easy to operation,no distortion during scaling of the vector diagram which is drawn by this system,meeting the demand of railway locomotive servicing and maintenance mapping.%为适应机务发展新环境,提高机车交路绘图效率,采用Visual Studio 2010开发工具研究并设计支持Win7环境的机车交路图辅助设计系统(CAD),该系统基于Microsoft Foundation Classes(MFC)类库运用面向对象的C++语言编程实现,兼容性好,操作简单,所绘矢量图缩放不失真,满足铁道机务绘图需求.

  16. Surgical planning and microvascular reconstruction of the mandible with a fibular flap using computer-aided design, rapid prototype modelling, and precontoured titanium reconstruction plates: a prospective study.

    Science.gov (United States)

    Sieira Gil, R; Roig, A Marí; Obispo, C Arranz; Morla, A; Pagès, C Martí; Perez, J Llopis

    2015-01-01

    The standard of mandibular reconstruction has increased since the introduction of computer-assisted design (CAD) and rapid prototype modelling (RPM) for surgical planning. Between 2008 and 2013, a prospective pilot study of 20 patients was planned to compare the outcomes of patients treated by mandibular reconstruction who had CAD and RPM-guided operations using a precontoured titanium plate, with the outcomes of patients treated conventionally. We recorded the time taken for reconstruction, total operating time, and whether this type of planning could improve the results of mandibular reconstruction. We found significant differences in the incidence of dental malocclusion (p=0.03) and exposure of the titanium plate (p=0.009). The mean operating time for reconstruction in the preoperative planning group was 135 (37)min compared with 176 (58)min in the conventional group (p=0.04). Preoperative planning using CAD and RPM can increase the accuracy of microvascular mandibular reconstruction and reduce the operating time for reconstruction. Copyright © 2014 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

  17. The Research of Computer Aided Farm Machinery Designing System Based on Ergonomics%计算机辅助农机产品的人机分析方法研究

    Institute of Scientific and Technical Information of China (English)

    郑颖; 高喜银

    2011-01-01

    The ergonomics question in farm machinery related to the safety and efficiency of operators, which was an important aspect in the farm machinery design. But the computer aided ergonomics software developed by abroad had no human body database, which was needed in view of farm machinery design in China. Therefore, the farm machinery design has deviation in ergonomics analysis. It was proposed to use the open database interface procedure in CATIA to establish human body database which was designed in view of the farm machinery design, and to read the human body data to ergonomics module of CATIA can produce practical application hypothesized person. Using human posture analysis and human activity analysis module to discuss the ergonomics in farm machinery, a new way for farm machinery ergonomics could be realized.%农机产品的人机问题关系到操作人员的安全和效率,是农机设计中的重要方面.由于国外开发的计算机辅助人机软件中没有中国农机设计所需的人体数据库,所以农机设计在人机分析上会存在偏差.提出利用CATIA开放的数据库接口程序建立针对农机设计的人体数据库,将人体数据读入到CATIA的人机模块中,生成实际应用的虚拟人,利用人体姿势分析和行为分析模块进行农机产品的人机分析,试图找到计算机辅助农机产品的人机分析设计的新方法.

  18. Computational-aided design of molecularly imprinted polymer for selective extraction of methadone from plasma and saliva and determination by gas chromatography.

    Science.gov (United States)

    Ahmadi, F; Rezaei, H; Tahvilian, R

    2012-12-28

    The main objective of this research was computational designing of an imprinted polymer for selective solid phase extraction (SPE) of methadone from plasma and saliva samples analyzed by gas chromatography-flam ionization detector (GC-FID). The density functional theory (DFT) at B3LYP/6-31G+ (d, p) level and Gaussian 2003 package was used to calculate the interaction energy of template-monomers (ΔE). The effect of polymerization solvent was also studied using polarizable continuum model (PCM). It was shown that, methacrylic acid (MAA) gave the largest ΔE in acetonitrile as a polymerization solvent. To examine the validity of this approach, two MIP were synthesized for methadone as template molecule and methacrylic acid as functional monomer in acetonitrile (AN) and methanol (MeOH), respectively. The performance of each polymer was evaluated by using imprinting effect. As it is expected, the best results were obtained for the molecularly imprinted polymer (MIP) which was prepared in AN. For the optimized method, the linearity between responses (peak areas) and concentration of methadone in plasma and saliva samples were found over the range of 3.6-40,000 ng mL(-1) (R(2)=0.997) and 3.0-40,000 ng mL(-1) (R(2)=0.998), respectively. The limit of detection (LOD) and limit of quantification (LOQ) for methadone in plasma were calculated to be 2.45 and 3.6 ng mL(-1), respectively. The LOD and LOQ for methadone in saliva were 2.14 and 3.0 ng mL(-1), respectively. The relative standard deviation (RSD; n=4) for plasma samples containing 10, 100, 500, 1000 ng mL(-1)of methadone were 5.98, 5.78, 5.52, 4.78, 4.74, and the RSD (n=4) for saliva sample containing 5, 20, 100, 1000 ng mL(-1) of methadone were 4.74, 5.1, 5.9, 5.6, respectively.

  19. Computer aided seismic and fire retrofitting analysis of existing high rise reinforced concrete buildings

    CERN Document Server

    Hussain, Raja Rizwan; Hasan, Saeed

    2016-01-01

    This book details the analysis and design of high rise buildings for gravity and seismic analysis. It provides the knowledge structural engineers need to retrofit existing structures in order to meet safety requirements and better prevent potential damage from such disasters as earthquakes and fires. Coverage includes actual case studies of existing buildings, reviews of current knowledge for damages and their mitigation, protective design technologies, and analytical and computational techniques. This monograph also provides an experimental investigation on the properties of fiber reinforced concrete that consists of natural fibres like coconut coir and also steel fibres that are used for comparison in both Normal Strength Concrete (NSC) and High Strength Concrete (HSC). In addition, the authors examine the use of various repair techniques for damaged high rise buildings. The book will help upcoming structural design engineers learn the computer aided analysis and design of real existing high rise buildings ...

  20. Integrated plant information technology design support functionality

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yeon Seung; Kim, Dae Jin [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of); Barber, P. W.; Goland, D. [Atomic Energy Canada Ltd., (Canada)

    1996-06-01

    This technical report was written as a result of Integrated Plant Information System (IPIS) feasibility study on CANDU 9 project which had been carried out from January, 1994 to March, 1994 at AECL (Atomic Energy Canada Limited) in Canada. From 1987, AECL had done endeavour to change engineering work process from paper based work process to computer based work process through CANDU 3 project. Even though AECL had a lot of good results form computerizing the Process Engineering, Instrumentation Control and Electrical Engineering, Mechanical Engineering, Computer Aided Design and Drafting, and Document Management System, but there remains the problem of information isolation and integration. On this feasibility study, IPIS design support functionality guideline was suggested by evaluating current AECL CAE tools, analyzing computer aided engineering task and work flow, investigating request for implementing integrated computer aided engineering and describing Korean request for future CANDU design including CANDU 9. 6 figs. (Author).