Detection of some safe plant-derived foods for LTP-allergic patients.

Science.gov (United States)

Asero, Riccardo; Mistrello, Gianni; Roncarolo, Daniela; Amato, Stefano

2007-01-01

Lipid transfer protein (LTP) is a widely cross-reacting plant pan-allergen. Adverse reactions to Rosaceae, tree nuts, peanut, beer, maize, mustard, asparagus, grapes, mulberry, cabbage, dates, orange, fig, kiwi, lupine, fennel, celery, tomato, eggplant, lettuce, chestnut and pineapple have been recorded. To detect vegetable foods to be regarded as safe for LTP-allergic patients. Tolerance/intolerance to a large spectrum of vegetable foods other than Rosaceae, tree nuts and peanut was assessed by interview in 49 subjects monosensitized to LTP and in three distinct groups of controls monosensitized to Bet v 1 (n = 24) or Bet v 2 (n = 18), or sensitized to both LTP and birch pollen (n = 16), all with a history of vegetable food allergy. Patients and controls underwent skin prick test (SPT) with a large spectrum of vegetable foods. The absence of IgE reactivity to foods that were negative in both clinical history and SPT was confirmed by immunoblot analysis and their clinical tolerance was finally assessed by open oral challenge (50 g per food). All patients reported tolerance and showed negative SPT to carrot, potato, banana and melon; these foods scored positive in SPT and elicited clinical symptoms in a significant proportion of patients from all three control groups. All patients tolerated these four foods on oral challenge. Immunoblot analysis confirmed the lack of IgE reactivity to these foods by LTP-allergic patients. Carrot, potato, banana and melon seem safe for LTP-allergic patients. This finding may be helpful for a better management of allergy to LTP.

Wild-Type, but Not Mutant N296H, Human Tau Restores Aβ-Mediated Inhibition of LTP in Tau−/− mice

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Mariana Vargas-Caballero

2017-04-01

Full Text Available Microtubule associated protein tau (MAPT is involved in the pathogenesis of Alzheimer's disease and many forms of frontotemporal dementia (FTD. We recently reported that Aβ-mediated inhibition of hippocampal long-term potentiation (LTP in mice requires tau. Here, we asked whether expression of human MAPT can restore Aβ-mediated inhibition on a mouse Tau−/− background and whether human tau with an FTD-causing mutation (N296H can interfere with Aβ-mediated inhibition of LTP. We used transgenic mouse lines each expressing the full human MAPT locus using bacterial artificial chromosome technology. These lines expressed all six human tau protein isoforms on a Tau−/− background. We found that the human wild-type MAPT H1 locus was able to restore Aβ42-mediated impairment of LTP. In contrast, Aβ42 did not reduce LTP in slices in two independently generated transgenic lines expressing tau protein with the mutation N296H associated with frontotemporal dementia (FTD. Basal phosphorylation of tau measured as the ratio of AT8/Tau5 immunoreactivity was significantly reduced in N296H mutant hippocampal slices. Our data show that human MAPT is able to restore Aβ42-mediated inhibition of LTP in Tau−/− mice. These results provide further evidence that tau protein is central to Aβ-induced LTP impairment and provide a valuable tool for further analysis of the links between Aβ, human tau and impairment of synaptic function.

The upgraded LTP-V at SLS

Energy Technology Data Exchange (ETDEWEB)

Flechsig, U., E-mail: uwe.flechsig@psi.ch [Paul Scherrer Institut, Swiss Light Source, 5232 Villigen-PSI (Switzerland); Jaggi, A.; Krempaský, J.; Spielmann, S.; Thominet, V. [Paul Scherrer Institut, Swiss Light Source, 5232 Villigen-PSI (Switzerland)

2013-05-11

Since 2005 the Swiss Light Source (SLS) has been operating a Long Trace Profiler (LTP)-V from Ocean Optics in its metrology laboratory to measure the synchrotron optics for SLS. In 2012 we finished a significant upgrade to improve the accuracy, reliability and measurement efficiency in particular for the calibration of adaptive optics. Folding mirrors with figure errors <λ/100 and an additional linear encoder have been installed, the 1d CCD detector with 2048 pixels has been replaced by a 16 mega-pixel CCD camera with gigabit ethernet interface GigE, the monolithic software has been replaced by a modular, full- EPICS compatible system based on a new LTP plugin for the areaDetector software for image processing. The plugin allows slope determination in real time i.e. per frame.

Dopamine Induces LTP Differentially in Apical and Basal Dendrites through BDNF and Voltage-Dependent Calcium Channels

Science.gov (United States)

Navakkode, Sheeja; Sajikumar, Sreedharan; Korte, Martin; Soong, Tuck Wah

2012-01-01

The dopaminergic modulation of long-term potentiation (LTP) has been studied well, but the mechanism by which dopamine induces LTP (DA-LTP) in CA1 pyramidal neurons is unknown. Here, we report that DA-LTP in basal dendrites is dependent while in apical dendrites it is independent of activation of L-type voltage-gated calcium channels (VDCC).…

Manifestations and possible sources of lunar transient phenomena (LTP)

International Nuclear Information System (INIS)

Cameron, W.S.

1975-01-01

Several different manifestations of lunar transient phenomena (LTP) have been reported. These include: (1) brightenings--both sudden and slow, (2) reddish--both bright and dull, (3) bluish--both bright and dull, (4) fairly abrupt dimmings or darkenings, and (5) obscurations, which may be accompanied by any of the other four manifestations. Approximately 200 lunar features exhibiting such anomalies have been reported at least once, but 80% of all observations are found in less than a dozen sites and 60% are found in about one-half dozen sites. An observing program is being conducted for the Association of Lunar and Planetary Observers which is designed to monitor the LTP sites, the seismic epicenter sites and non-LTP comparison sites. It addresses the ''brightenings'' category of observations and is designed to establish normal brightness of each observed feature for all phases of a lunation. It also seeks to establish a quantified ''seeing'' scale. About one-half dozen observers have reported albedo measures (estimated from an albedo scale set up by each observer). The most extensive new data on albedo versus age (phase of Moon) are for the crater Dawes. Several LTP effects have been discerned in Dawes. In addition, seeing estimates, based on the behavior of a star's diffraction disk, provided some unexpected results when disk behavior is compared with other subjective estimates of seeing

Encoding of Discriminative Fear Memory by Input-Specific LTP in the Amygdala.

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Kim, Woong Bin; Cho, Jun-Hyeong

2017-08-30

In auditory fear conditioning, experimental subjects learn to associate an auditory conditioned stimulus (CS) with an aversive unconditioned stimulus. With sufficient training, animals fear conditioned to an auditory CS show fear response to the CS, but not to irrelevant auditory stimuli. Although long-term potentiation (LTP) in the lateral amygdala (LA) plays an essential role in auditory fear conditioning, it is unknown whether LTP is induced selectively in the neural pathways conveying specific CS information to the LA in discriminative fear learning. Here, we show that postsynaptically expressed LTP is induced selectively in the CS-specific auditory pathways to the LA in a mouse model of auditory discriminative fear conditioning. Moreover, optogenetically induced depotentiation of the CS-specific auditory pathways to the LA suppressed conditioned fear responses to the CS. Our results suggest that input-specific LTP in the LA contributes to fear memory specificity, enabling adaptive fear responses only to the relevant sensory cue. VIDEO ABSTRACT. Copyright © 2017 Elsevier Inc. All rights reserved.

CaMKII Requirement for in Vivo Insular Cortex LTP Maintenance and CTA Memory Persistence

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Yectivani Juárez-Muñoz

2017-11-01

Full Text Available Calcium-calmodulin/dependent protein kinase II (CaMKII plays an essential role in LTP induction, but since it has the capacity to remain persistently activated even after the decay of external stimuli it has been proposed that it can also be necessary for LTP maintenance and therefore for memory persistence. It has been shown that basolateral amygdaloid nucleus (Bla stimulation induces long-term potentiation (LTP in the insular cortex (IC, a neocortical region implicated in the acquisition and retention of conditioned taste aversion (CTA. Our previous studies have demonstrated that induction of LTP in the Bla-IC pathway before CTA training increased the retention of this task. Although it is known that IC-LTP induction and CTA consolidation share similar molecular mechanisms, little is known about the molecular actors that underlie their maintenance. The purpose of the present study was to evaluate the role of CaMKII in the maintenance of in vivo Bla-IC LTP as well as in the persistence of CTA long-term memory (LTM. Our results show that acute microinfusion of myr-CaMKIINtide, a selective inhibitor of CaMKII, in the IC of adult rats during the late-phase of in vivo Bla-IC LTP blocked its maintenance. Moreover, the intracortical inhibition of CaMKII 24 h after CTA acquisition impairs CTA-LTM persistence. Together these results indicate that CaMKII is a central key component for the maintenance of neocortical synaptic plasticity as well as for persistence of CTA-LTM.

Afferent input selects NMDA receptor subtype to determine the persistency of hippocampal LTP in freely behaving mice

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Jesús Javier Ballesteros

2016-10-01

Full Text Available The glutamatergic N-methyl-D-aspartate receptor (NMDAR is critically involved in many forms of hippocampus-dependent memory that may be enabled by synaptic plasticity. Behavioral studies with NMDAR antagonists and NMDAR subunit (GluN2 mutants revealed distinct contributions from GluN2A- and GluN2B-containing NMDARs to rapidly and slowly acquired memory performance. Furthermore, studies of synaptic plasticity, in genetically modified mice in vitro, suggest that GluN2A and GluN2B may contribute in different ways to the induction and longevity of synaptic plasticity. In contrast to the hippocampal slice preparation, in behaving mice, the afferent frequencies that induce synaptic plasticity are very restricted and specific. In fact, it is the stimulus pattern, and not variations in afferent frequency that determine the longevity of long-term potentiation (LTP. Here, we explored the contribution of GluN2A and GluN2B to LTP of differing magnitudes and persistencies in freely behaving mice. We applied differing high-frequency stimulation (HFS patterns at 100 Hz to the hippocampal CA1 region, to induce NMDAR-dependent LTP in wild-type (WT mice, that endured for 24h (late (L-LTP. In GluN2A-KO mice, E-LTP (HFS, 50 pulses was significantly reduced in magnitude and duration, whereas LTP (HFS, 2 x 50 pulses and L-LTP (HFS, 4 x 50 pulses were unaffected compared to responses in WT animals. By contrast, pharmacological antagonism of GluN2B in WT had no effect on E-LTP but significantly prevented LTP. E- LTP and LTP were significantly impaired by GluN2B antagonism in GluN2A-KO mice. These data indicate that the pattern of afferent stimulation is decisive for the recruitment of distinct GluN2A and GluN2B signaling pathways that in turn determine the persistency of hippocampal LTP. Whereas brief bursts of patterned stimulation preferentially recruit GluN2A and lead to weak and short-lived forms of LTP, prolonged, more intense, afferent activation recruits GluN2B

Motor learning interference is proportional to occlusion of LTP-like plasticity.

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Cantarero, Gabriela; Tang, Byron; O'Malley, Rebecca; Salas, Rachel; Celnik, Pablo

2013-03-13

Learning interference occurs when learning something new causes forgetting of an older memory (retrograde interference) or when learning a new task disrupts learning of a second subsequent task (anterograde interference). This phenomenon, described in cognitive, sensory, and motor domains, limits our ability to learn multiple tasks in close succession. It has been suggested that the source of interference is competition of neural resources, although the neuronal mechanisms are unknown. Learning induces long-term potentiation (LTP), which can ultimately limit the ability to induce further LTP, a phenomenon known as occlusion. In humans we quantified the magnitude of occlusion of anodal transcranial direct current stimulation-induced increased excitability after learning a skill task as an index of the amount of LTP-like plasticity used. We found that retention of a newly acquired skill, as reflected by performance in the second day of practice, is proportional to the magnitude of occlusion. Moreover, the degree of behavioral interference was correlated with the magnitude of occlusion. Individuals with larger occlusion after learning the first skill were (1) more resilient to retrograde interference and (2) experienced larger anterograde interference when training a second task, as expressed by decreased performance of the learned skill in the second day of practice. This effect was not observed if sufficient time elapsed between training the two skills and LTP-like occlusion was not present. These findings suggest competition of LTP-like plasticity is a factor that limits the ability to remember multiple tasks trained in close succession.

Thermal diagnostics for LTP

International Nuclear Information System (INIS)

Lobo, Alberto; Nofrarias, M; Sanjuan, J

2005-01-01

This is a short note reporting on the current state of development of the temperature sensors which are part of the LTP Diagnostics Subsystem on board the LISA Pathfinder mission (LPF). A thermal insulator has been designed which ensures sufficient stability of a set of eight NTC sensors (negative temperature coefficient of resistance or thermistors), and the front-end electronics has also been designed and manufactured. Tests have been performed which nearly approach the goal of a global stability of 10 -5 K Hz -1/2

MGluR5 mediates the interaction between late-LTP, network activity, and learning.

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Arthur Bikbaev

2008-05-01

Full Text Available Hippocampal synaptic plasticity and learning are strongly regulated by metabotropic glutamate receptors (mGluRs and particularly by mGluR5. Here, we investigated the mechanisms underlying mGluR5-modulation of these phenomena. Prolonged pharmacological blockade of mGluR5 with MPEP produced a profound impairment of spatial memory. Effects were associated with 1 a reduction of mGluR1a-expression in the dentate gyrus; 2 impaired dentate gyrus LTP; 3 enhanced CA1-LTP and 4 suppressed theta (5-10 Hz and gamma (30-100 Hz oscillations in the dentate gyrus. Allosteric potentiation of mGluR1 after mGluR5 blockade significantly ameliorated dentate gyrus LTP, as well as suppression of gamma oscillatory activity. CA3-lesioning prevented MPEP effects on CA1-LTP, suggesting that plasticity levels in CA1 are driven by mGluR5-dependent synaptic and network activity in the dentate gyrus. These data support the hypothesis that prolonged mGluR5-inactivation causes altered hippocampal LTP levels and network activity, which is mediated in part by impaired mGluR1-expression in the dentate gyrus. The consequence is impairment of long-term learning.

Discovering long-term potentiation (LTP) - recollections and reflections on what came after.

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Lømo, T

2018-02-01

Chance events led me to a lifelong career in scientific research. They paved the way for being the first to see long-term potentiation of synaptic efficiency (LTP) in Per Andersen's laboratory in Oslo in 1966. Here I describe my way to this discovery and the experiments with Tim Bliss in 1968-1969 that led to Bliss and Lømo, 1973. Surprisingly, we later failed to reproduce these results. I discuss possible reasons for this failure, which made us both leave LTP research, in my case for good, in Tim's case for several years. After 30 years of work in a different field, I renewed my interest in the hippocampus and LTP in the early 2000s and published, for the first time, results that I had obtained 40 years earlier. Here I present my take on how interest in and research on LTP evolved after the early years. This includes a discussion of the functions of hippocampus as seen in those early days, the case of patient H.M., Donald Hebb's place in the story, the search for 'memory molecules' such as PKMζ, and the primary site for LTP expression (pre- and/or post-synaptic?). Throughout, I reflect on my life in science, how science is done and what drives it. The reflections are quite personal and I admit to mixed feelings about broadcasting them. © 2017 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd.

Calcium microdomains near R-type calcium channels control the induction of presynaptic LTP at parallel fiber to Purkinje cell synapses

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Myoga, Michael H.; Regehr, Wade G.

2011-01-01

R-type calcium channels in postsynaptic spines signal through functional calcium microdomains to regulate a calcium-calmodulin sensitive potassium channel that in turn regulates postsynaptic hippocampal LTP. Here we ask whether R-type calcium channels in presynaptic terminals also signal through calcium microdomains to control presynaptic LTP. We focus on presynaptic LTP at parallel fiber to Purkinje cell synapses in the cerebellum (PF-LTP), which is mediated by calcium/calmodulin-stimulated adenylyl cyclases. Although most presynaptic calcium influx is through N-type and P/Q-type calcium channels, blocking these channels does not disrupt PF-LTP, but blocking R-type calcium channels does. Moreover, global calcium signaling cannot account for the calcium dependence of PF-LTP because R-type channels contribute modestly to overall calcium entry. These findings indicate that within presynaptic terminals, R-type calcium channels produce calcium microdomains that evoke presynaptic LTP at moderate frequencies that do not greatly increase global calcium levels,. PMID:21471358

The effects of lindane and long-term potentiation (LTP) on pyramidal cell excitability in the rat hippocampal slice.

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Albertson, T E; Walby, W F; Stark, L G; Joy, R M

1997-01-01

An in vitro orthodromic stimulation technique was used to examine the effects of lindane and long-term potentiation (LTP) inducing stimuli, alone or in combination, on the excitatory afferent terminal of CA1 pyramidal cells and on recurrent collateral evoked inhibition using the rat hippocampal slice model. Hippocampal slices of 400 microns thickness were perfused with oxygenated artificial cerebrospinal fluid. Stimulation of Schaffer collateral/commissural fibers produced extracellular excitatory postsynaptic potential (EPSP) and/or populations spike (PS) responses recorded from electrodes in the CA1 region. A paired-pulse technique was used to measure gamma-aminobutyric acid (GABAA)-mediated recurrent inhibition before and after treatments. After both lindane and LTP, larger PS amplitudes for a given stimulus intensity were seen. The resulting leftward shift in the curve of the PS amplitude versus stimulus intensity was larger after LTP than after 25 microM lindane. Both lindane and LTP treatments reduced PS thresholds and reduced or eliminated recurrent inhibition as measured by paired-pulse stimulation at the 15 msec interval. The reduction of recurrent inhibition after both treatments was more pronounced at lower stimulus intensities. When LTP stimuli were applied after lindane exposure a further large shift to the left was seen in the PS amplitude versus stimulus intensity curve. A smaller shift to the left was seen in the PS amplitude versus stimulus intensity curve only at the higher stimuli when lindane exposure occurred after LTP. Only at low stimulus intensities were further argumentations seen in PS amplitudes when the LTP stimuli was followed by a second LTP stimuli. Previous exposure to 25 microM lindane stimuli does not block the development of a further robust LTP in this in vitro model.

Screening of agrochemicals in foodstuffs using low-temperature plasma (LTP) ambient ionization mass spectrometry.

Science.gov (United States)

Wiley, Joshua S; García-Reyes, Juan F; Harper, Jason D; Charipar, Nicholas A; Ouyang, Zheng; Cooks, R Graham

2010-05-01

Low-temperature plasma (LTP) permits direct ambient ionization and mass analysis of samples in their native environment with minimal or no prior preparation. LTP utilizes dielectric barrier discharges (DBDs) to create a low power plasma which is guided by gas flow onto the sample from which analytes are desorbed and ionized. In this study, the potential of LTP-MS for the detection of pesticide residues in food is demonstrated. Thirteen multi-class agricultural chemicals were studied (ametryn, amitraz, atrazine, buprofezin, DEET, diphenylamine, ethoxyquin, imazalil, isofenphos-methyl, isoproturon, malathion, parathion-ethyl and terbuthylazine). To evaluate the potential of the proposed approach, LTP-MS experiments were performed directly on fruit peels as well as on fruit/vegetable extracts. Most of the agrochemicals examined displayed remarkable sensitivity in the positive ion mode, giving limits of detection (LOD) for the direct measurement in the low picogram range. Tandem mass spectrometry (MS/MS) was used to confirm identification of selected pesticides by using for these experiments spiked fruit/vegetable extracts (QuEChERS, a standard sample treatment protocol) at levels as low as 1 pg, absolute, for some of the analytes. Comparisons of the data obtained by direct LTP-MS were made with the slower but more accurate conventional LC-MS/MS procedure. Herbicides spiked in aqueous solutions were detectable at LODs as low as 0.5 microg L(-1) without the need for any sample preparation. The results demonstrate that ambient LTP-MS can be applied for the detection and confirmation of traces of agrochemicals in actual market-purchased produce and in natural water samples. Quantitative analysis was also performed in a few selected cases and displayed a relatively high degree of linearity over four orders of magnitude.

The ltp gene of temperate Streptococcus thermophilus phage TP-J34 confers superinfection exclusion to Streptococcus thermophilus and Lactococcus lactis

International Nuclear Information System (INIS)

Sun Xingmin; Goehler, Andre; Heller, Knut J.; Neve, Horst

2006-01-01

The ltp gene, located within the lysogeny module of temperate Streptococcus thermophilus phage TP-J34, has been shown to be expressed in lysogenic strain S. thermophilus J34. It codes for a lipoprotein, as demonstrated by inhibition of cleavage of the signal sequence by globomycin. Exposure of Ltp on the surface of Lactococcus lactis protoplasts bearing a plasmid-encoded copy of ltp has been demonstrated by immunogold labeling and electron microscopy. Expression of ltp in prophage- and plasmid-cured S. thermophilus J34-6f interfered with TP-J34 infection. While plating efficiency was reduced by a factor of about 40 and lysis of strain J34-6f in liquid medium was delayed considerably, phage adsorption was not affected at all. Intracellular accumulation of phage DNA was shown to be inhibited by Ltp. This indicates interference of Ltp with infection at the stage of triggering DNA release and injection into the cell, indicating a role of Ltp in superinfection exclusion. Expression of ltp in L. lactis Bu2-60 showed that the same superinfection exclusion mechanism was strongly effective against phage P008, a member of the lactococcal 936 phage species: no plaque-formation was detectable with even 10 9 phage per ml applied, and lysis in liquid medium did not occur. In Lactococcus also, Ltp apparently inhibited phage DNA release and/or injection. Ltp appears to be a member of a family of small, secreted proteins with a 42 amino acids repeat structure encoded by genes of Gram-positive bacteria. Some of these homologous genes are part of the genomes of prophages

ASIC-dependent LTP at multiple glutamatergic synapses in amygdala network is required for fear memory.

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Chiang, Po-Han; Chien, Ta-Chun; Chen, Chih-Cheng; Yanagawa, Yuchio; Lien, Cheng-Chang

2015-05-19

Genetic variants in the human ortholog of acid-sensing ion channel-1a subunit (ASIC1a) gene are associated with panic disorder and amygdala dysfunction. Both fear learning and activity-induced long-term potentiation (LTP) of cortico-basolateral amygdala (BLA) synapses are impaired in ASIC1a-null mice, suggesting a critical role of ASICs in fear memory formation. In this study, we found that ASICs were differentially expressed within the amygdala neuronal population, and the extent of LTP at various glutamatergic synapses correlated with the level of ASIC expression in postsynaptic neurons. Importantly, selective deletion of ASIC1a in GABAergic cells, including amygdala output neurons, eliminated LTP in these cells and reduced fear learning to the same extent as that found when ASIC1a was selectively abolished in BLA glutamatergic neurons. Thus, fear learning requires ASIC-dependent LTP at multiple amygdala synapses, including both cortico-BLA input synapses and intra-amygdala synapses on output neurons.

Hippocampal NPY gene transfer attenuates seizures without affecting epilepsy-induced impairment of LTP

DEFF Research Database (Denmark)

Sørensen, Andreas T; Nikitidou, Litsa; Ledri, Marco

2009-01-01

(TLE). However, our previous studies show that recombinant adeno-associated viral (rAAV)-NPY treatment in naive rats attenuates long-term potentiation (LTP) and transiently impairs hippocampal learning process, indicating that negative effect on memory function could be a potential side effect of NPY...... is significantly attenuated in vitro. Importantly, transgene NPY overexpression has no effect on short-term synaptic plasticity, and does not further compromise LTP in kindled animals. These data suggest that epileptic seizure-induced impairment of memory function in the hippocampus may not be further affected...... injected with rAAV-NPY, we show that rapid kindling-induced hippocampal seizures in vivo are effectively suppressed as compared to rAAV-empty injected (control) rats. Six to nine weeks later, basal synaptic transmission and short-term synaptic plasticity are unchanged after rapid kindling, while LTP...

Overexpression of wheat lipid transfer protein gene TaLTP5 increases resistances to Cochliobolus sativus and Fusarium graminearum in transgenic wheat.

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Zhu, Xiuliang; Li, Zhao; Xu, Huijun; Zhou, Miaoping; Du, Lipu; Zhang, Zengyan

2012-08-01

The fungus Cochliobolus sativus is the main pathogen of common root rot, a serious soil-borne disease of wheat (Triticum aestivum L.). The fungus Fusarium graminearum is the primary pathogen of Fusarium head blight, a devastating disease of wheat worldwide. In this study, the wheat lipid transfer protein gene, TaLTP5, was cloned and evaluated for its ability to suppress disease development in transgenic wheat. TaLTP5 expression was induced after C. sativus infection. The TaLTP5 expression vector, pA25-TaLTP5, was constructed and bombarded into Chinese wheat variety Yangmai 18. Six TaLTP5 transgenic wheat lines were established and characterized. PCR and Southern blot analyses indicated that the introduced TaLTP5 gene was integrated into the genomes of six transgenic wheat lines by distinct patterns, and heritable. RT-PCR and real-time quantitative RT-PCR revealed that the TaLTP5 gene was over-expressed in the transgenic wheat lines compared to segregants lacking the transgene and wild-type wheat plants. Following challenge with C. sativus or F. graminearum, all six transgenic lines overexpressing TaLTP5 exhibited significantly enhanced resistance to both common root rot and Fusarium head blight compared to the untransformed wheat Yangmai 18.

Activation of PAF-synthesizing enzymes in rat brain stem slices after LTP induction in the medial vestibular nuclei.

Science.gov (United States)

Francescangeli, Ermelinda; Grassi, Silvarosa; Pettorossi, Vito E; Goracci, Gianfrancesco

2002-11-01

LysoPAF acetyltransferase (lysoPAF-AT) and PAF-synthesizing phosphocholinetransferase (PAF-PCT) are the two enzymes which catalyze the final reactions for the synthesis of PAF. Their activities, assayed in the homogenate of rat brain stem slices and under their optimal conditions, increased 5 min after high frequency stimulation of vestibular afferents, inducing LTP in the medial vestibular nuclei. The activity of phosphatidylcholine-synthesizing phosphocholinetransferase, was not affected. Sixty minutes from the induction of LTP, PAF-PCT activity, but not that of lysoPAF-AT, was still significantly higher with respect to 5 min test stimulated control. We used AP-5 to verify whether this increase was strictly dependent upon LTP induction, which requires NMDA receptor activation. In AP-5 treated slices, lysoPAF-acetyltransferase and PAF-synthesizing phosphocholinetransferase activities increased, but they were reduced after high frequency stimulation under AP-5. In conclusion, we have demonstrated that the activities of PAF-synthesizing enzymes are activated soon after the induction of LTP and that this effect is linked to the activation of NMDA-receptors. We suggest that the enzyme activation by AP-5, preventing LTP, might be due to glutamate enhancement but, in neurons showing LTP and under normal conditions, the activation of potentiation mechanisms is critical for the enhancement of enzyme activities.

Learning, memory and hippocampal LTP in genetically obese rodents

Institute of Scientific and Technical Information of China (English)

无

2001-01-01

We have found that leptin, at physiological concentrations of 10-12 mol/L, facilitates learning and memory and LTP maintenance in Wistar rats. To explore the role of leptin recepors in learning, memory and synaptic plasticity, experiments were carried out using Zucker rats (Z), db/db mice (db), and ob/ob mice(ob). The former two have defects in leptin receptors and the latter cannot produce normal leptin. Unlike the effects observed in normal rats, high or low frequency stimulation of Schaffer collateral-CA1 synapses in hippocampal slices prepared from Z, db and ob animals failed to induce the learning and memory relevant long-term potentiation or depression in CA1 neurons. However, LTP in ob CA1 synapses was facilitated by leptin at 10-12 mol/L concentration. Moreover, the paired-pulse facilitation of CA1 synaptic potentials and intracellularly recorded postsynaptic responses to the neurotransmitters AMPA, NMDA and GABA, applied electrophoretically to the apical dendrites of CA1 neurons, were approximately the same compared to the control lean animals. In addition, unlike the second messenger responses observed in Wistar rats, calmodulin kinase Ⅱ activity in the CA1 area of Z and db animals was not activated after tetanic stimulation of the Schaffer collaterals. It has been shown that all three strains, Z, db and ob display impaired spatial learning and memory when tested in the Morris water maze. The results of these experiments indicate a close relationship between spatial learning and memory, facilitation of LTP, and calmodulin kinase Ⅱ　activity.

BraLTP1, a lipid transfer protein gene involved in epicuticular wax deposition, cell proliferation and flower development in Brassica napus.

Directory of Open Access Journals (Sweden)

Fang Liu

Full Text Available Plant non-specific lipid transfer proteins (nsLTPs constitute large multigene families that possess complex physiological functions, many of which remain unclear. This study isolated and characterized the function of a lipid transfer protein gene, BraLTP1 from Brassica rapa, in the important oilseed crops Brassica napus. BraLTP1 encodes a predicted secretory protein, in the little known VI Class of nsLTP families. Overexpression of BnaLTP1 in B. napus caused abnormal green coloration and reduced wax deposition on leaves and detailed wax analysis revealed 17-80% reduction in various major wax components, which resulted in significant water-loss relative to wild type. BnaLTP1 overexpressing leaves exhibited morphological disfiguration and abaxially curled leaf edges, and leaf cross-sections revealed cell overproliferation that was correlated to increased cytokinin levels (tZ, tZR, iP, and iPR in leaves and high expression of the cytokinin biosynthsis gene IPT3. BnaLTP1-overexpressing plants also displayed morphological disfiguration of flowers, with early-onset and elongated carpel development and outwardly curled stamen. This was consistent with altered expression of a a number of ABC model genes related to flower development. Together, these results suggest that BraLTP1 is a new nsLTP gene involved in wax production or deposition, with additional direct or indirect effects on cell division and flower development.

Involvement of intracellular Zn2+ signaling in LTP at perforant pathway-CA1 pyramidal cell synapse.

Science.gov (United States)

Tamano, Haruna; Nishio, Ryusuke; Takeda, Atsushi

2017-07-01

Physiological significance of synaptic Zn 2+ signaling was examined at perforant pathway-CA1 pyramidal cell synapses. In vivo long-term potentiation (LTP) at perforant pathway-CA1 pyramidal cell synapses was induced using a recording electrode attached to a microdialysis probe and the recording region was locally perfused with artificial cerebrospinal fluid (ACSF) via the microdialysis probe. Perforant pathway LTP was not attenuated under perfusion with CaEDTA (10 mM), an extracellular Zn 2+ chelator, but attenuated under perfusion with ZnAF-2DA (50 μM), an intracellular Zn 2+ chelator, suggesting that intracellular Zn 2+ signaling is required for perforant pathway LTP. Even in rat brain slices bathed in CaEDTA in ACSF, intracellular Zn 2+ level, which was measured with intracellular ZnAF-2, was increased in the stratum lacunosum-moleculare where perforant pathway-CA1 pyramidal cell synapses were contained after tetanic stimulation. These results suggest that intracellular Zn 2+ signaling, which originates in internal stores/proteins, is involved in LTP at perforant pathway-CA1 pyramidal cell synapses. Because the influx of extracellular Zn 2+ , which originates in presynaptic Zn 2+ release, is involved in LTP at Schaffer collateral-CA1 pyramidal cell synapses, synapse-dependent Zn 2+ dynamics may be involved in plasticity of postsynaptic CA1 pyramidal cells. © 2017 Wiley Periodicals, Inc.

Blockade of intracellular Zn2+ signaling in the basolateral amygdala affects object recognition memory via attenuation of dentate gyrus LTP.

Science.gov (United States)

Fujise, Yuki; Kubota, Mitsuyasu; Suzuki, Miki; Tamano, Haruna; Takeda, Atsushi

2017-09-01

Hippocampus-dependent memory is modulated by the amygdala. However, it is unknown whether intracellular Zn 2+ signaling in the amygdala is involved in hippocampus-dependent memory. On the basis of the evidence that intracellular Zn 2+ signaling in dentate granule cells (DGC) is necessary for object recognition memory via LTP at medial perforant pathway (PP)-DGC synapses, the present study examined whether intracellular Zn 2+ signaling in the amygdala influences object recognition memory via modulation of LTP at medial PP-DGC synapses. When ZnAF-2DA (100 μM, 2 μl) was injected into the basolateral amygdala (BLA), intracellular ZnAF-2 locally chelated intracellular Zn 2+ in the amygdala. Recognition memory was affected when training of object recognition test was performed 20 min after ZnAF-2DA injection into the BLA. Twenty minutes after injection of ZnAF-2DA into the BLA, LTP induction at medial PP-DGC synapses was attenuated, while LTP induction at PP-BLA synapses was potentiated and LTP induction at BLA-DGC synapses was attenuated. These results suggest that intracellular Zn 2+ signaling in the BLA is involved in BLA-associated LTP and modulates LTP at medial PP-DGC synapses, followed by modulation of object recognition memory. Copyright © 2017 Elsevier Ltd. All rights reserved.

Acupuncture Prevents the Impairment of Hippocampal LTP Through β1-AR in Vascular Dementia Rats.

Science.gov (United States)

Xiao, Ling-Yong; Wang, Xue-Rui; Yang, Jing-Wen; Ye, Yang; Zhu, Wen; Cao, Yan; Ma, Si-Ming; Liu, Cun-Zhi

2018-02-13

It is widely accepted that the synaptic dysfunction and synapse loss contribute to the cognitive deficits of vascular dementia (VD) patients. We have previously reported that acupuncture improved cognitive function in rats with VD. However, the mechanisms involved in acupuncture improving cognitive ability remain to be elucidated. The present study aims to investigate the pathways and molecules involved in the neuroprotective effect of acupuncture. We assessed the effects of acupuncture on hippocampal long-term potentiation (LTP), the most prominent cellular model of memory formation. Acupuncture enhanced LTP and norepinephrine (NE) levels in the hippocampus. Inhibition of the β-adrenergic receptor (AR), but not the α-AR, was able to block the effects of acupuncture on hippocampal LTP. Furthermore, inhibition of β1-AR, not β2-AR, abolished the enhanced LTP induced by acupuncture. The expression analysis revealed a significant upregulation of β1-AR and unchanged β2-AR with acupuncture, which supported the above findings. Specifically, increased β1-ARs in the dentate gyrus were expressed on neurons exclusively. Taken together, the present data supports a beneficial role of acupuncture in synaptic plasticity challenged with VD. A likely mechanism is the increase of NE and activation of β1-AR in the hippocampus.

Maintained LTP and Memory Are Lost by Zn2+ Influx into Dentate Granule Cells, but Not Ca2+ Influx.

Science.gov (United States)

Takeda, Atsushi; Tamano, Haruna; Hisatsune, Marie; Murakami, Taku; Nakada, Hiroyuki; Fujii, Hiroaki

2018-02-01

The idea that maintained LTP and memory are lost by either increase in intracellular Zn 2+ in dentate granule cells or increase in intracellular Ca 2+ was examined to clarify significance of the increases induced by excess synapse excitation. Both maintained LTP and space memory were impaired by injection of high K + into the dentate gyrus, but rescued by co-injection of CaEDTA, which blocked high K + -induced increase in intracellular Zn 2+ but not high K + -induced increase in intracellular Ca 2+ . High K + -induced disturbances of LTP and intracellular Zn 2+ are rescued by co-injection of 6-cyano-7-nitroquinoxakine-2,3-dione, an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor antagonist, but not by co-injection of blockers of NMDA receptors, metabotropic glutamate receptors, and voltage-dependent calcium channels. Furthermore, AMPA impaired maintained LTP and the impairment was also rescued by co-injection of CaEDTA, which blocked increase in intracellular Zn 2+ , but not increase in intracellular Ca 2+ . NMDA and glucocorticoid, which induced Zn 2+ release from the internal stores, did not impair maintained LTP. The present study indicates that increase in Zn 2+ influx into dentate granule cells through AMPA receptors loses maintained LTP and memory. Regulation of Zn 2+ influx into dentate granule cells is more critical for not only memory acquisition but also memory retention than that of Ca 2+ influx.

LTP-like plasticity in the visual system and in the motor system appear related in young and healthy subjects

Directory of Open Access Journals (Sweden)

Stefan eKlöppel

2015-09-01

Full Text Available LTP-like plasticity measured by visual evoked potentials (VEP can be induced in the intact human brain by presenting checkerboard reversals. Also associated with LTP-like plasticity, around two third of participants respond to transcranial magnetic stimulation with a paired-associate stimulation (PAS protocol with a potentiation of their motor evoked potentials. LTP-like processes are also required for verbal and motor learning tasks. We compared effect sizes, responder rates and intercorrelations as well as the potential influence of attention between these four assessments in a group of 37 young and healthy volunteers. We observed a potentiation effect of the N75 and P100 VEP component which positively correlated with plasticity induced by PAS. Subjects with a better subjective alertness were more likely to show PAS and VEP potentiation. No correlation was found between the other assessments. Effect sizes and responder rates of VEP potentiation were higher compared to PAS. Our results indicate a high variability of LTP-like effects and no evidence for a system-specific nature. As a consequence, studies wishing to assess individual levels of LTP-like plasticity should employ a combination of multiple assessments.

Redistribution of ionotropic glutamate receptors detected by laser microdissection of the rat dentate gyrus 48 h following LTP induction in vivo.

Directory of Open Access Journals (Sweden)

Jeremy T T Kennard

Full Text Available The persistence and input specificity of long-term potentiation (LTP make it attractive as a mechanism of information storage. In its initial phase, both in vivo and in vitro studies have shown that LTP is associated with increased membrane localization of AMPA receptor subunits, but the molecular basis of LTP maintenance over the long-term is still unclear. We have previously shown that expression of AMPA and NMDA receptor subunits is elevated in whole homogenates prepared from dentate gyrus 48 h after LTP induction in vivo. In the present study, we utilized laser microdissection (LMD techniques to determine whether AMPA and NMDA receptor upregulation occurs specifically in the stimulated regions of the dentate gyrus dendritic arbor. Receptor proteins GluN1, GluA1 and GluA2, as well as postsynaptic density protein of 95 kDa and tubulin were detected by Western blot analysis in microdissected samples. Gradients of expression were observed for GluN1 and GluA2, decreasing from the inner to the outer zones of the molecular layer, and were independent of LTP. When induced at medial perforant path synapses, LTP was associated with an apparent specific redistribution of GluA1 and GluN1 to the middle molecular layer that contains these synapses. These data indicate that glutamate receptor proteins are delivered specifically to dendritic regions possessing LTP-expressing synapses, and that these changes are preserved for at least 48 h.

Human sensory Long-Term Potentiation (LTP) predicts visual memory performance and is modulated by the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism

OpenAIRE

King, Rohan; Moreau, David; Russell, Bruce; Kirk, Ian; Wu, Carolyn; Antia, Ushtana; Lamb, Yvette; Spriggs, Meg; Thompson, Chris; Mckay, Nicole; Shelling, Andrew; Waldie, Karen; Teyler, Tim; Hamm, Jeff; Mcnair, Nicolas

2018-01-01

Background: Long-Term Potentiation (LTP) is recognised as a core neuronal process underlying long-term memory. However, a direct relationship between LTP and human memory performance is yet to be demonstrated. The first aim of the current study was thus to assess the relationship between LTP and human long-term memory performance. With this also comes an opportunity to explore factors thought to mediate the relationship between LTP and long-term memory, and to gain additional insight into var...

Cholinergic induction of input-specific late-phase LTP via localized Ca2+ release in the visual cortex.

Science.gov (United States)

Cho, Kwang-Hyun; Jang, Hyun-Jong; Jo, Yang-Hyeok; Singer, Wolf; Rhie, Duck-Joo

2012-03-28

Acetylcholine facilitates long-term potentiation (LTP) and long-term depression (LTD), substrates of learning, memory, and sensory processing, in which acetylcholine also plays a crucial role. Ca(2+) ions serve as a canonical regulator of LTP/LTD but little is known about the effect of acetylcholine on intracellular Ca(2+) dynamics. Here, we investigated dendritic Ca(2+) dynamics evoked by synaptic stimulation and the resulting LTP/LTD in layer 2/3 pyramidal neurons of the rat visual cortex. Under muscarinic stimulation, single-shock electrical stimulation (SES) inducing ∼20 mV EPSP, applied via a glass electrode located ∼10 μm from the basal dendrite, evoked NMDA receptor-dependent fast Ca(2+) transients and the subsequent Ca(2+) release from the inositol 1,4,5-trisphosphate (IP(3))-sensitive stores. These secondary dendritic Ca(2+) transients were highly localized within 10 μm from the center (SD = 5.0 μm). The dendritic release of Ca(2+) was a prerequisite for input-specific muscarinic LTP (LTPm). Without the secondary Ca(2+) release, only muscarinic LTD (LTDm) was induced. D(-)-2-amino-5-phosphopentanoic acid and intracellular heparin blocked LTPm as well as dendritic Ca(2+) release. A single burst consisting of 3 EPSPs with weak stimulus intensities instead of the SES also induced secondary Ca(2+) release and LTPm. LTPm and LTDm were protein synthesis-dependent. Furthermore, LTPm was confined to specific dendritic compartments and not inducible in distal apical dendrites. Thus, cholinergic activation facilitated selectively compartment-specific induction of late-phase LTP through IP(3)-dependent Ca(2+) release.

Comparison of LTI and LTP Models for Stability Analysis of Grid Converters

DEFF Research Database (Denmark)

Kwon, Jun Bum; Wang, Xiongfei; Blaabjerg, Frede

2016-01-01

The stability analysis of grid-connected converters have attracted increasing attentions, due to the oscillations arising in wind power plants, micro-grids, and other emerging power electronics based power systems. The modeling tool of converters thus becomes essential to faithfully reveal...... oscillations without any hidden regions. This paper presents a detailed comparison of two linearized modeling methods, which are, respectively, developed in the Linear Time-Invariant (LTI) and the Linear Time-Periodic (LTP) frameworks. The LTP model can consider the effect of frequency-coupling dynamics, which...... are occurred by the time-varying behavior, while the conventional LTI model can not capture this behavior. The advantages and limits of two models are then illustrated with examples. The compared results are verified in the frequency domain and time domain as well....

Ceramic Technology Project

Energy Technology Data Exchange (ETDEWEB)

1992-03-01

The Ceramic Technology Project was developed by the USDOE Office of Transportation Systems (OTS) in Conservation and Renewable Energy. This project, part of the OTS's Materials Development Program, was developed to meet the ceramic technology requirements of the OTS's automotive technology programs. Significant accomplishments in fabricating ceramic components for the USDOE and NASA advanced heat engine programs have provided evidence that the operation of ceramic parts in high-temperature engine environments is feasible. These programs have also demonstrated that additional research is needed in materials and processing development, design methodology, and data base and life prediction before industry will have a sufficient technology base from which to produce reliable cost-effective ceramic engine components commercially. A five-year project plan was developed with extensive input from private industry. In July 1990 the original plan was updated through the estimated completion of development in 1993. The objective is to develop the industrial technology base required for reliable ceramics for application in advanced automotive heat engines. The project approach includes determining the mechanisms controlling reliability, improving processes for fabricating existing ceramics, developing new materials with increased reliability, and testing these materials in simulated engine environments to confirm reliability. Although this is a generic materials project, the focus is on the structural ceramics for advanced gas turbine and diesel engines, ceramic bearings and attachments, and ceramic coatings for thermal barrier and wear applications in these engines. To facilitate the rapid transfer of this technology to US industry, the major portion of the work is being done in the ceramic industry, with technological support from government laboratories, other industrial laboratories, and universities.

Alzheimer's Disease Brain-Derived Amyloid-{beta}-Mediated Inhibition of LTP In Vivo Is Prevented by Immunotargeting Cellular Prion Protein.

LENUS (Irish Health Repository)

Barry, Andrew E

2011-05-18

Synthetic amyloid-β protein (Aβ) oligomers bind with high affinity to cellular prion protein (PrP(C)), but the role of this interaction in mediating the disruption of synaptic plasticity by such soluble Aβ in vitro is controversial. Here we report that intracerebroventricular injection of Aβ-containing aqueous extracts of Alzheimer\\'s disease (AD) brain robustly inhibits long-term potentiation (LTP) without significantly affecting baseline excitatory synaptic transmission in the rat hippocampus in vivo. Moreover, the disruption of LTP was abrogated by immunodepletion of Aβ. Importantly, intracerebroventricular administration of antigen-binding antibody fragment D13, directed to a putative Aβ-binding site on PrP(C), prevented the inhibition of LTP by AD brain-derived Aβ. In contrast, R1, a Fab directed to the C terminus of PrP(C), a region not implicated in binding of Aβ, did not significantly affect the Aβ-mediated inhibition of LTP. These data support the pathophysiological significance of SDS-stable Aβ dimer and the role of PrP(C) in mediating synaptic plasticity disruption by soluble Aβ.

The New Mexico Technology Deployment Pilot Project: A technology reinvestment project. Final report

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-11-01

The New Mexico Technology Deployment Project (NMTDP) has been in operation for slightly more than two years. As one of the original TRP projects, NMTDP had the charter to develop and validate a new model for technology extraction which emphasized focused technology collaboration, early industry involvement, and a strong dual use commercialization and productization emphasis. Taken in total, the first two years of the NMTDP have been exceptionally successful, surpassing the goals of the project. This report describes the accomplishments and evolution of the NMTDP to date and discusses the future potential of the project. Despite the end of federal funding, and a subsequent reduction in level of effort, the project partners are committed to continuation of the project.

Blockade of intracellular Zn2+ signaling in the dentate gyrus erases recognition memory via impairment of maintained LTP.

Science.gov (United States)

Tamano, Haruna; Minamino, Tatsuya; Fujii, Hiroaki; Takada, Shunsuke; Nakamura, Masatoshi; Ando, Masaki; Takeda, Atsushi

2015-08-01

There is no evidence on the precise role of synaptic Zn2+ signaling on the retention and recall of recognition memory. On the basis of the findings that intracellular Zn2+ signaling in the dentate gyrus is required for object recognition, short-term memory, the present study deals with the effect of spatiotemporally blocking Zn2+ signaling in the dentate gyrus after LTP induction and learning. Three-day-maintained LTP was impaired 1 day after injection of clioquinol into the dentate gyrus, which transiently reduced intracellular Zn2+ signaling in the dentate gyrus. The irreversible impairment was rescued not only by co-injection of ZnCl2 , which ameliorated the loss of Zn2+ signaling, but also by pre-injection of Jasplakinolide, a stabilizer of F-actin, prior to clioquinol injection. Simultaneously, 3-day-old space recognition memory was impaired 1 day after injection of clioquinol into the dentate gyrus, but not by pre-injection of Jasplakinolide. Jasplakinolide also rescued both impairments of 3-day-maintained LTP and 3-day-old memory after injection of ZnAF-2DA into the dentate gyrus, which blocked intracellular Zn2+ signaling in the dentate gyrus. The present paper indicates that the blockade and/or loss of intracellular Zn2+ signaling in the dentate gyrus coincidently impair maintained LTP and recognition memory. The mechanism maintaining LTP via intracellular Zn2+ signaling in dentate granule cells, which may be involved in the formation of F-actin, may retain space recognition memory. © 2015 Wiley Periodicals, Inc.

Involvement of glucocorticoid-mediated Zn2+ signaling in attenuation of hippocampal CA1 LTP by acute stress.

Science.gov (United States)

Takeda, Atsushi; Suzuki, Miki; Tamano, Haruna; Takada, Shunsuke; Ide, Kazuki; Oku, Naoto

2012-03-01

Glucocorticoid-glutamatergic interactions have been proposed as a potential model to explain stress-mediated impairment of cognition. However, it is unknown whether glucocorticoid-zincergic interactions are involved in this impairment. Histochemically reactive zinc (Zn(2+)) is co-released with glutamate from zincergic neurons. In the present study, involvement of synaptic Zn(2+) in stress-induced attenuation of CA1 LTP was examined in hippocampal slices from young rats after exposure to tail suspension stress for 30s, which significantly increased serum corticosterone. Stress-induced attenuation of CA1 LTP was ameliorated by administration of clioquinol, a membrane permeable zinc chelator, to rats prior to exposure to stress, implying that the reduction of synaptic Zn(2+) by clioquinol participates in this amelioration. To pursue the involvement of corticosterone-mediated Zn(2+) signal in the attenuated CA1 LTP by stress, dynamics of synaptic Zn(2+) was checked in hippocampal slices exposed to corticosterone. Corticosterone increased extracellular Zn(2+) levels measured with ZnAF-2 dose-dependently, as well as the intracellular Ca(2+) levels measured with calcium orange AM, suggesting that corticosterone excites zincergic neurons in the hippocampus and increases Zn(2+) release from the neuron terminals. Intracellular Zn(2+) levels measured with ZnAF-2DA were also increased dose-dependently, but not in the coexistence of CaEDTA, a membrane-impermeable zinc chelator, suggesting that intracellular Zn(2+) levels is increased by the influx of extracellular Zn(2+). Furthermore, corticosterone-induced attenuation of CA1 LTP was abolished in the coexistence of CaEDTA. The present study suggests that corticosterone-mediated increase in postsynaptic Zn(2+) signal in the cytosolic compartment is involved in the attenuation of CA1 LTP after exposure to acute stress. Copyright © 2012 Elsevier Ltd. All rights reserved.

A Voltage-Based STDP Rule Combined with Fast BCM-Like Metaplasticity Accounts for LTP and Concurrent "Heterosynaptic" LTD in the Dentate Gyrus In Vivo.

Directory of Open Access Journals (Sweden)

Peter Jedlicka

2015-11-01

Full Text Available Long-term potentiation (LTP and long-term depression (LTD are widely accepted to be synaptic mechanisms involved in learning and memory. It remains uncertain, however, which particular activity rules are utilized by hippocampal neurons to induce LTP and LTD in behaving animals. Recent experiments in the dentate gyrus of freely moving rats revealed an unexpected pattern of LTP and LTD from high-frequency perforant path stimulation. While 400 Hz theta-burst stimulation (400-TBS and 400 Hz delta-burst stimulation (400-DBS elicited substantial LTP of the tetanized medial path input and, concurrently, LTD of the non-tetanized lateral path input, 100 Hz theta-burst stimulation (100-TBS, a normally efficient LTP protocol for in vitro preparations produced only weak LTP and concurrent LTD. Here we show in a biophysically realistic compartmental granule cell model that this pattern of results can be accounted for by a voltage-based spike-timing-dependent plasticity (STDP rule combined with a relatively fast Bienenstock-Cooper-Munro (BCM-like homeostatic metaplasticity rule, all on a background of ongoing spontaneous activity in the input fibers. Our results suggest that, at least for dentate granule cells, the interplay of STDP-BCM plasticity rules and ongoing pre- and postsynaptic background activity determines not only the degree of input-specific LTP elicited by various plasticity-inducing protocols, but also the degree of associated LTD in neighboring non-tetanized inputs, as generated by the ongoing constitutive activity at these synapses.

Future Low Temperature Plasma Science and Technology: Attacking Major Societal Problems by Building on a Tradition of Scientific Rigor

Science.gov (United States)

Graves, David

2014-10-01

Low temperature plasma (LTP) science is unequivocally one of the most prolific areas for varied applications in modern technology. For example, plasma etching technology is essential for reliably and rapidly patterning nanometer scale features over areas approaching one square meter with relatively inexpensive equipment. This technology enabled the telecommunication and information processing revolution that has transformed human society. I explore two concepts in this talk. The first is that the firm scientific understanding of LTP is and has been the enabling feature of these established technological applications. And the second is that LTP technology is poised to contribute to several emerging societal challenges. Beyond the important, ongoing applications of LTP science to problems of materials processing related to energy generation (e.g. thin film solar cell manufacture), there are novel and less well known potential applications in food and agriculture, infection control and medicine. In some cases, the potentially low cost nature of the applications in so compelling that they can be thought of as examples of frugal innovation. Supported in part by NSF and DoE.

Methamphetamine reduces LTP and increases baseline synaptic transmission in the CA1 region of mouse hippocampus.

Directory of Open Access Journals (Sweden)

Jarod Swant

2010-06-01

Full Text Available Methamphetamine (METH is an addictive psychostimulant whose societal impact is on the rise. Emerging evidence suggests that psychostimulants alter synaptic plasticity in the brain--which may partly account for their adverse effects. While it is known that METH increases the extracellular concentration of monoamines dopamine, serotonin, and norepinephrine, it is not clear how METH alters glutamatergic transmission. Within this context, the aim of the present study was to investigate the effects of acute and systemic METH on basal synaptic transmission and long-term potentiation (LTP; an activity-induced increase in synaptic efficacy in CA1 sub-field in the hippocampus. Both the acute ex vivo application of METH to hippocampal slices and systemic administration of METH decreased LTP. Interestingly, the acute ex vivo application of METH at a concentration of 30 or 60 microM increased baseline synaptic transmission as well as decreased LTP. Pretreatment with eticlopride (D2-like receptor antagonist did not alter the effects of METH on synaptic transmission or LTP. In contrast, pretreatment with D1/D5 dopamine receptor antagonist SCH23390 or 5-HT1A receptor antagonist NAN-190 abrogated the effect of METH on synaptic transmission. Furthermore, METH did not increase baseline synaptic transmission in D1 dopamine receptor haploinsufficient mice. Our findings suggest that METH affects excitatory synaptic transmission via activation of dopamine and serotonin receptor systems in the hippocampus. This modulation may contribute to synaptic maladaption induced by METH addiction and/or METH-mediated cognitive dysfunction.

Performance of the upgraded LTP-II at the ALS Optical Metrology Laboratory

International Nuclear Information System (INIS)

Advanced Light Source; Yashchuk, Valeriy V; Kirschman, Jonathan L.; Domning, Edward E.; McKinney, Wayne R.; Morrison, Gregory Y.; Smith, Brian V.; Yashchuk, Valeriy V.

2008-01-01

The next generation of synchrotrons and free electron laser facilities requires x-ray optical systems with extremely high performance, generally of diffraction limited quality. Fabrication and use of such optics requires adequate, highly accurate metrology and dedicated instrumentation. Previously, we suggested ways to improve the performance of the Long Trace Profiler (LTP), a slope measuring instrument widely used to characterize x-ray optics at long spatial wavelengths. The main way is use of a CCD detector and corresponding technique for calibration of photo-response non-uniformity [J. L. Kirschman, et al., Proceedings of SPIE 6704, 67040J (2007)]. The present work focuses on the performance and characteristics of the upgraded LTP-II at the ALS Optical Metrology Laboratory. This includes a review of the overall aspects of the design, control system, the movement and measurement regimes for the stage, and analysis of the performance by a slope measurement of a highly curved super-quality substrate with less than 0.3 microradian (rms)slope variation

[Earth Science Technology Office's Computational Technologies Project

Science.gov (United States)

Fischer, James (Technical Monitor); Merkey, Phillip

2005-01-01

This grant supported the effort to characterize the problem domain of the Earth Science Technology Office's Computational Technologies Project, to engage the Beowulf Cluster Computing Community as well as the High Performance Computing Research Community so that we can predict the applicability of said technologies to the scientific community represented by the CT project and formulate long term strategies to provide the computational resources necessary to attain the anticipated scientific objectives of the CT project. Specifically, the goal of the evaluation effort is to use the information gathered over the course of the Round-3 investigations to quantify the trends in scientific expectations, the algorithmic requirements and capabilities of high-performance computers to satisfy this anticipated need.

The Space Technology-7 Disturbance Reduction System Precision Control Flight Validation Experiment Control System Design

Science.gov (United States)

O'Donnell, James R.; Hsu, Oscar C.; Maghami, Peirman G.; Markley, F. Landis

2006-01-01

As originally proposed, the Space Technology-7 Disturbance Reduction System (DRS) project, managed out of the Jet Propulsion Laboratory, was designed to validate technologies required for future missions such as the Laser Interferometer Space Antenna (LISA). The two technologies to be demonstrated by DRS were Gravitational Reference Sensors (GRSs) and Colloidal MicroNewton Thrusters (CMNTs). Control algorithms being designed by the Dynamic Control System (DCS) team at the Goddard Space Flight Center would control the spacecraft so that it flew about a freely-floating GRS test mass, keeping it centered within its housing. For programmatic reasons, the GRSs were descoped from DRS. The primary goals of the new mission are to validate the performance of the CMNTs and to demonstrate precise spacecraft position control. DRS will fly as a part of the European Space Agency (ESA) LISA Pathfinder (LPF) spacecraft along with a similar ESA experiment, the LISA Technology Package (LTP). With no GRS, the DCS attitude and drag-free control systems make use of the sensor being developed by ESA as a part of the LTP. The control system is designed to maintain the spacecraft s position with respect to the test mass, to within 10 nm/the square root of Hz over the DRS science frequency band of 1 to 30 mHz.

Expression of NMDA receptor-dependent LTP in the hippocampus: bridging the divide

Directory of Open Access Journals (Sweden)

Bliss Tim VP

2013-01-01

Full Text Available Abstract A consensus has famously yet to emerge on the locus and mechanisms underlying the expression of the canonical NMDA receptor-dependent form of LTP. An objective assessment of the evidence leads us to conclude that both presynaptic and postsynaptic expression mechanisms contribute to this type of synaptic plasticity.

Smart Gun Technology project. Final report

Energy Technology Data Exchange (ETDEWEB)

Weiss, D.R.

1996-05-01

The goal of the Smart Gun Technology project is to eliminate the capability of an unauthorized user form firing a law officer`s firearm by implementing user-recognizing-and-authorizing (or {open_quotes}smart{close_quotes}) surety technologies. This project was funded by the National Institute of Justice. This report lists the findings and results of the project`s three primary objectives. First, to find and document the requirements for a smart firearm technology that law enforcement officers will value. Second, to investigate, evaluate, and prioritize technologies that meet the requirements for a law enforcement officer`s smart firearm. Third, to demonstrate and document the most promising technology`s usefulness in models of a smart firearm.

Excess influx of Zn(2+) into dentate granule cells affects object recognition memory via attenuated LTP.

Science.gov (United States)

Suzuki, Miki; Fujise, Yuki; Tsuchiya, Yuka; Tamano, Haruna; Takeda, Atsushi

2015-08-01

The influx of extracellular Zn(2+) into dentate granule cells is nonessential for dentate gyrus long-term potentiation (LTP) and the physiological significance of extracellular Zn(2+) dynamics is unknown in the dentate gyrus. Excess increase in extracellular Zn(2+) in the hippocampal CA1, which is induced with excitation of zincergic neurons, induces memory deficit via excess influx of Zn(2+) into CA1 pyramidal cells. In the present study, it was examined whether extracellular Zn(2+) induces object recognition memory deficit via excess influx of Zn(2+) into dentate granule cells. KCl (100 mM, 2 µl) was locally injected into the dentate gyrus. The increase in intracellular Zn(2+) in dentate granule cells induced with high K(+) was blocked by co-injection of CaEDTA and CNQX, an extracellular Zn(2+) chelator and an AMPA receptor antagonist, respectively, suggesting that high K(+) increases the influx of Zn(2+) into dentate granule cells via AMPA receptor activation. Dentate gyrus LTP induction was attenuated 1 h after KCl injection into the dentate gyrus and also attenuated when KCl was injected 5 min after the induction. Memory deficit was induced when training of object recognition test was performed 1 h after KCl injection into the dentate gyrus and also induced when KCl was injected 5 min after the training. High K(+)-induced impairments of LTP and memory were rescued by co-injection of CaEDTA. These results indicate that excess influx of Zn(2+) into dentate granule cells via AMPA receptor activation affects object recognition memory via attenuated LTP induction. Even in the dentate gyrus where is scarcely innervated by zincergic neurons, it is likely that extracellular Zn(2+) homeostasis is strictly regulated for cognition. Copyright © 2015 Elsevier Ltd. All rights reserved.

How does technological regime affect performance of technology development projects?

NARCIS (Netherlands)

Song, Michael; Hooshangi, Soheil; Zhao, Y. Lisa; Halman, Johannes I.M.

2014-01-01

In this study, we examine how technological regime affects the performance of technology development projects (i.e., project quality, sales, and profit). Technological regime is defined as the set of attributes of a technological environment where the innovative activities of firms take place.

Weakened Intracellular Zn2+-Buffering in the Aged Dentate Gyrus and Its Involvement in Erasure of Maintained LTP.

Science.gov (United States)

Takeda, Atsushi; Tamano, Haruna; Murakami, Taku; Nakada, Hiroyuki; Minamino, Tatsuya; Koike, Yuta

2018-05-01

Memory is lost by the increased influx of extracellular Zn 2+ into neurons. It is possible that intracellular Zn 2+ dynamics is modified even at non-zincergic medial perforant pathway-dentate granule cell synapses along with aging and that vulnerability to the modification is linked to age-related cognitive decline. To examine these possibilities, vulnerability of long-term potentiation (LTP) maintenance, which underlies memory retention, to modification of synaptic Zn 2+ dynamics was compared between young and aged rats. The influx of extracellular Zn 2+ into dentate granule cells was increased in aged rats after injection of high K + into the dentate gyrus, but not in young rats. This increase impaired maintained LTP in aged rats. However, the impairment was rescued by co-injection of CaEDTA, an extracellular Zn 2+ chelator, or CNQX, an AMPA receptor antagonist, which suppressed the Zn 2+ influx. Maintained LTP was also impaired in aged rats after injection of ZnAF-2DA into the dentate gyrus that chelates intracellular Zn 2+ , but not in young rats. Interestingly, the capacity of chelating intracellular Zn 2+ with intracellular ZnAF-2 was almost lost in the aged dentate gyrus 2 h after injection of ZnAF-2DA into the dentate gyrus, suggesting that intracellular Zn 2+ -buffering is weakened in the aged dentate gyrus, compared to the young dentate gyrus. In the dentate gyrus of aged rats, maintained LTP is more vulnerable to modification of intracellular Zn 2+ dynamics than in young rats, probably due to weakened intracellular Zn 2+ -buffering.

Shippingport station decommissioning project technology transfer program

International Nuclear Information System (INIS)

McKernan, M.L.

1989-01-01

The US Department of Energy (DOE) Shippingport Station Decommissioning Project (SSDP) decontaminated and dismantled the world's first nuclear-fueled, commercial-size electric power plant. The SSDP programmatic goal direction for technology transfer is documentation of project management and operations experience. The objective is to provide future nuclear facility decommissioning projects with pertinent SSDP performance data for project assessment, planning, and operational implementation. This paper sets out access and availability directions for SSDP technology acquisition. Discusses are technology transfer definition; technology transfer products including topical and other project reports, professional-technical society presentations, other project liaison and media relations, visual documentation, and technology transfer data base; and retrieving SSDP information

The effect of acute swim stress and training in the water maze on hippocampal synaptic activity as well as plasticity in the dentate gyrus of freely moving rats: revisiting swim-induced LTP reinforcement.

Science.gov (United States)

Tabassum, Heena; Frey, Julietta U

2013-12-01

Hippocampal long-term potentiation (LTP) is a cellular model of learning and memory. An early form of LTP (E-LTP) can be reinforced into its late form (L-LTP) by various behavioral interactions within a specific time window ("behavioral LTP-reinforcement"). Depending on the type and procedure used, various studies have shown that stress differentially affects synaptic plasticity. Under low stress, such as novelty detection or mild foot shocks, E-LTP can be transformed into L-LTP in the rat dentate gyrus (DG). A reinforcing effect of a 2-min swim, however, has only been shown in (Korz and Frey (2003) J Neurosci 23:7281-7287; Korz and Frey (2005) J Neurosci 25:7393-7400; Ahmed et al. (2006) J Neurosci 26:3951-3958; Sajikumar et al., (2007) J Physiol 584.2:389-400) so far. We have reinvestigated these studies using the same as well as an improved recording technique which allowed the recording of field excitatory postsynaptic potentials (fEPSP) and the population spike amplitude (PSA) at their places of generation in freely moving rats. We show that acute swim stress led to a long-term depression (LTD) in baseline values of PSA and partially fEPSP. In contrast to earlier studies a LTP-reinforcement by swimming could never be reproduced. Our results indicate that 2-min swim stress influenced synaptic potentials as well as E-LTP negatively. Copyright © 2013 Wiley Periodicals, Inc.

Project of Atomic Energy Technology Record

International Nuclear Information System (INIS)

Song, K. C.; Ko, Y. C.; Kwon, K. C.

2012-12-01

Project of the Atomic Energy Technology Record is the project that summarizes and records whole process, from the background to the performance, of each category in all fields of nuclear science technology which have been researched and developed at KAERI. This project includes development of Data And Documents Advanced at KAERI. This project includes development of Data And Documents Advanced Management System(DADAMS) to collect, organize and preserve various records occurred in each research and development process. In addition, it means the whole records related to nuclear science technology for the past, present and future. This report summarizes research contents and results of 'Project of Atomic Energy Technology Record'. Section 2 summarizes the theoretical background, the current status of records management in KAERI and the overview of this project. And Section 3 to 6 summarize contents and results performed in this project. Section 3 is about the process of sectoral technology record, Section 4 summarizes the process of Information Strategy Master Plan(ISMP), Section 5 summarizes the development of Data And Documents Advanced Management System(DADAMS) and Section 6 summarizes the process of collecting, organizing and digitalizing of records

Projecting technology change to improve space technology planning and systems management

Science.gov (United States)

Walk, Steven Robert

2011-04-01

Projecting technology performance evolution has been improving over the years. Reliable quantitative forecasting methods have been developed that project the growth, diffusion, and performance of technology in time, including projecting technology substitutions, saturation levels, and performance improvements. These forecasts can be applied at the early stages of space technology planning to better predict available future technology performance, assure the successful selection of technology, and improve technology systems management strategy. Often what is published as a technology forecast is simply scenario planning, usually made by extrapolating current trends into the future, with perhaps some subjective insight added. Typically, the accuracy of such predictions falls rapidly with distance in time. Quantitative technology forecasting (QTF), on the other hand, includes the study of historic data to identify one of or a combination of several recognized universal technology diffusion or substitution patterns. In the same manner that quantitative models of physical phenomena provide excellent predictions of system behavior, so do QTF models provide reliable technological performance trajectories. In practice, a quantitative technology forecast is completed to ascertain with confidence when the projected performance of a technology or system of technologies will occur. Such projections provide reliable time-referenced information when considering cost and performance trade-offs in maintaining, replacing, or migrating a technology, component, or system. This paper introduces various quantitative technology forecasting techniques and illustrates their practical application in space technology and technology systems management.

Advantages of the in-situ LTP distortion profile test on high-heat-load mirrors and applications

International Nuclear Information System (INIS)

Qian, S.; Jark, W.; Sostero, G.; Gambitta, A.; Mazzolini, F.; Savoia, A.

1996-01-01

The first in-situ distortion profile measurement of a high heat load mirror by use of the penta-prism LTP is presented. A maximum height distortion of 0.47 micron in tangential direction over a length of 180 mm was measured for an internally water-cooled mirror of a undulator beam line at ELETTRA while exposed to a total emitted power of 600 W (undulator gap 30 mm and current 180 mA). The experiment has an accuracy and repeatability of 0.04 micron. The test schematic and the test equipment are presented. Two measuring methods to scan a penta-prism being installed either outside or inside the vacuum chamber are introduced. Advantages and some possible applications of adopting the penta-prism LTP to make the in-situ profile test are explained

Biochemical principles underlying the stable maintenance of LTP by the CaMKII/NMDAR complex.

Science.gov (United States)

Lisman, John; Raghavachari, Sridhar

2015-09-24

Memory involves the storage of information at synapses by an LTP-like process. This information storage is synapse specific and can endure for years despite the turnover of all synaptic proteins. There must, therefore, be special principles that underlie the stability of LTP. Recent experimental results suggest that LTP is maintained by the complex of CaMKII with the NMDAR. Here we consider the specifics of the CaMKII/NMDAR molecular switch, with the goal of understanding the biochemical principles that underlie stable information storage by synapses. Consideration of a variety of experimental results suggests that multiple principles are involved. One switch requirement is to prevent spontaneous transitions from the off to the on state. The highly cooperative nature of CaMKII autophosphorylation by Ca(2+) (Hill coefficient of 8) and the fact that formation of the CaMKII/NMDAR complex requires release of CaMKII from actin are mechanisms that stabilize the off state. The stability of the on state depends critically on intersubunit autophosphorylation, a process that restores any loss of pT286 due to phosphatase activity. Intersubunit autophosphorylation is also important in explaining why on state stability is not compromised by protein turnover. Recent evidence suggests that turnover occurs by subunit exchange. Thus, stability could be achieved if a newly inserted unphosphorylated subunit was autophosphorylated by a neighboring subunit. Based on other recent work, we posit a novel mechanism that enhances the stability of the on state by protection of pT286 from phosphatases. We posit that the binding of the NMNDAR to CaMKII forces pT286 into the catalytic site of a neighboring subunit, thereby protecting pT286 from phosphatases. A final principle concerns the role of structural changes. The binding of CaMKII to the NMDAR may act as a tag to organize the binding of further proteins that produce the synapse enlargement that underlies late LTP. We argue that these

Technological economics: innovation, project management, and technology transfer

Energy Technology Data Exchange (ETDEWEB)

Bradbury, F R

1981-06-01

The relationship between economics and technology, as well as their interaction in production, productivity, project management, and in technology transfer processes are reviewed. Over the last two decades there has been an increasing interest by economists in the technologist's view of technical change and its mechanisms. The author looks at the zone between technology and economics, the technological economics, and discusses the theory of innovation recently sketched out by Nelson and Winter. The relevance to project management and technology transfer of contemporary writing by economists leads to the view that there are welcome signs of a convergence of the conceptual models now emerging and the practical problems of technology management and movement. Economists now seem more willing to come to terms with technology than technologists with economics. The economic significance of the multitudes of technically unglamorous activities in development work is seriously neglected as a result of over-emphasis on the spectacular technological break. If economic elegance were to be admitted to the criteria of success, one might get a significant improvement in the engineering of technological change. 29 references, 4 figure.

Pilot project of atomic energy technology record

International Nuclear Information System (INIS)

Song, K. C.; Kim, Y. I.; Kim, Y. G.

2011-12-01

Project of the Atomic Energy Technology Record is the project that summarizes and records in each category as a whole summary from the background to the performance at all fields of nuclear science technology which researched and developed at KAERI. This project includes Data and Document Management System(DDMS) that will be the system to collect, organize and preserve various records occurred in each research and development process. To achieve these goals, many problems should be solved to establish technology records process, such as issues about investigation status of technology records in KAERI, understanding and collection records, set-up project system and selection target field, definition standards and range of target records. This is a research report on the arrangement of research contents and results about pilot project which records whole nuclear technology researched and developed at KAERI in each category. Section 2 summarizes the overview of this pilot project and the current status of technology records in domestic and overseas, and from Section 3 to Section 6 summarize contents and results which performed in this project. Section 3 summarizes making TOC(Table of Content) and technology records, Section 4 summarizes sectoral templates, Section 5 summarizes writing detailed plan of technology records, and Section 6 summarizes Standard Document Numbering System(SDNS). Conclusions of this report are described in Section 7

Functional optical probing of the hippocampal trisynaptic circuit in vitro: network dynamics, filter properties, and polysynaptic induction of CA1 LTP.

Science.gov (United States)

Stepan, Jens; Dine, Julien; Eder, Matthias

2015-01-01

Decades of brain research have identified various parallel loops linking the hippocampus with neocortical areas, enabling the acquisition of spatial and episodic memories. Especially the hippocampal trisynaptic circuit [entorhinal cortex layer II → dentate gyrus (DG) → cornu ammonis (CA)-3 → CA1] was studied in great detail because of its seemingly simple connectivity and characteristic structures that are experimentally well accessible. While numerous researchers focused on functional aspects, obtained from a limited number of cells in distinct hippocampal subregions, little is known about the neuronal network dynamics which drive information across multiple synapses for subsequent long-term storage. Fast voltage-sensitive dye imaging in vitro allows real-time recording of activity patterns in large/meso-scale neuronal networks with high spatial resolution. In this way, we recently found that entorhinal theta-frequency input to the DG most effectively passes filter mechanisms of the trisynaptic circuit network, generating activity waves which propagate across the entire DG-CA axis. These "trisynaptic circuit waves" involve high-frequency firing of CA3 pyramidal neurons, leading to a rapid induction of classical NMDA receptor-dependent long-term potentiation (LTP) at CA3-CA1 synapses (CA1 LTP). CA1 LTP has been substantially evidenced to be essential for some forms of explicit learning in mammals. Here, we review data with particular reference to whole network-level approaches, illustrating how activity propagation can take place within the trisynaptic circuit to drive formation of CA1 LTP.

Shippingport station decommissioning project technology transfer program

International Nuclear Information System (INIS)

McKernan, M.L.

1988-01-01

US Department of Energy (DOE) Shippingport Station Decommissioning Project (SSDP) decommissioned, decontaminated, and dismantled the world's first, nuclear fueled, commercial size, electric power plant. SSDP programmatic goal direction for technology transfer is documentation of project management and operations experience. Objective is to provide future nuclear facility decommissioning projects with pertinent SSDP performance data for project assessment, planning, and operational implementation. This paper presents a working definition for technology transfer. Direction is provided for access and availability for SSDP technology acquisition

Transformational Tools and Technologies Project

Data.gov (United States)

National Aeronautics and Space Administration — The Transformational Tools and Technologies (TTT) Project advances state-of-the-art computational and experimental tools and technologies that are vital to aviation...

Pomegranate ( Punica granatum L.) expresses several nsLTP isoforms characterized by different immunoglobulin E-binding properties.

Science.gov (United States)

Bolla, Michela; Zenoni, Sara; Scheurer, Stephan; Vieths, Stefan; San Miguel Moncin, Maria Del Mar; Olivieri, Mario; Antico, Andrea; Ferrer, Marta; Berroa, Felicia; Enrique, Ernesto; Avesani, Linda; Marsano, Francesco; Zoccatelli, Gianni

2014-01-01

Pomegranate allergy is associated with sensitization to non-specific lipid transfer proteins (nsLTPs). Our aim was to identify and characterize the non-specific nsLTPs expressed in pomegranate at the molecular level and to study their allergenic properties in terms of immunoglobulin E (IgE)-binding and cross-reactivity with peach nsLTP (Pru p 3). A non-equilibrium two-dimensional (2-D) electrophoretic approach based on acid-urea PAGE and sodium dodecyl sulfate PAGE was set up to separate pomegranate nsLTPs. Their immunoreactivity was tested by immunoblotting carried out with anti-Pru p 3 polyclonal antibodies and sera from pomegranate-allergic patients. For final identification, pomegranate nsLTPs were purified by chromatography and subjected to trypsin digestion and mass spectrometry (MS) analysis. For this purpose, the sequences obtained by cDNA cloning of three pomegranate nsLTPs were integrated in the database that was subsequently searched for MS data interpretation. Four nsLTPs were identified by 2-D immunoblotting. The detected proteins showed different IgE-binding capacity and partial cross-reactivity with Pru p 3. cDNA cloning and MS analyses led to the identification of three nsLTP isoforms with 66-68% amino acid sequence identity named Pun g 1.0101, Pun g 1.0201 and Pun g 1.0301. By 2-D electrophoresis, we could separate different nsLTP isoforms possessing different IgE-binding properties, which might reflect peculiar allergenic potencies. The contribution of Pru p 3 to prime sensitization is not central as in other plant nsLTPs. © 2014 S. Karger AG, Basel.

Technology Education Professional Enhancement Project

Science.gov (United States)

Hughes, Thomas A., Jr.

1996-01-01

The two goals of this project are: the use of integrative field of aerospace technology to enhance the content and instruction delivered by math, science, and technology teachers through the development of a new publication entitled NASA Technology Today, and to develop a rationale and structure for the study of technology, which establishes the foundation for developing technology education standards and programs of the future.

Lack of LTP-like plasticity in primary motor cortex in Parkinson's disease.

Science.gov (United States)

Suppa, A; Marsili, L; Belvisi, D; Conte, A; Iezzi, E; Modugno, N; Fabbrini, G; Berardelli, A

2011-02-01

In this study in patients with Parkinson's disease (PD), off and on dopaminergic therapy, with and without L-dopa-induced dyskinesias (LIDs), we tested intermittent theta-burst stimulation (iTBS), a technique currently used for non-invasively inducing long-term potentiation (LTP)-like plasticity in primary motor cortex (M1). The study group comprised 20 PD patients on and off dopaminergic therapy (11 patients without and 9 patients with LIDs), and 14 age-matched healthy subjects. Patients had mild-to-moderate PD, and no additional neuropsychiatric disorders. We clinically evaluated patients using the Unified Parkinson's Disease Rating Scale (UPDRS) and the Unified Dyskinesia Rating Scale (UDysRS). The left M1 was conditioned with iTBS at 80% active motor threshold intensity. Twenty motor evoked potentials (MEPs) were recorded from right first interosseous muscle before and at 5, 15 and 30 min after iTBS. Between-group analysis of variance (ANOVA) testing healthy subjects versus patients with and without LIDs, on and off therapy showed a significant interaction between factors "Group" and "Time". After iTBS, MEP amplitudes in healthy subjects increased significantly at 5, 15 and 30 min (piTBS fails to increase MEP responses. This finding suggests lack of iTBS-induced LTP-like plasticity in M1 in PD regardless of patients' clinical features. Copyright © 2010 Elsevier Inc. All rights reserved.

CNPC Appoints Chief Experts for Important Technological Projects

Institute of Scientific and Technical Information of China (English)

Zhao Jianzhong

2006-01-01

@@ On June 27th, China National Petroleum Corporation (CNPC) held a public recruitment to appoint chief experts in Beijing for its important technological projects, which is the first time for CNPC to appoint chief managers by the means of competitive recruitment. This recruitment covers four projects, such as drilling, logging, geophysical survey and ground engineering with 15 projects. Of those,there are 8 drilling projects, which make up 50 percent of all the important technological projects for public recruitment. CNPC expects to further boost the chief expert responsibility system and promote the research and development (R&D) of technological project on the basis of the public recruitment. The company completes the recruitment following the procedure of making announcement, conducting competitive recruitment and giving publicity. On July 25th, the appointment ceremony was held by CNPC and 15 experts were awarded the certificates. CNPC is entering a new stage for the implementation of the technology and talent strategy for the 11th Five-Year Plan. What's more, a new management mode is taking shape for the technological project and for the construction of technological personnel pool.

Canadian Fusion Fuels Technology Project activities report

International Nuclear Information System (INIS)

1985-01-01

The Canadian Fusion Fuels Technology Project was formally established in 1982. The project is directed toward the further development of Canadian capabilities in five major areas: tritium technology, breeder technology, materials technology, equipment development and safety and the environment. The project is funded by three partners - Government of Canada (50%), Ontario Provincial Government (25%) and Ontario Hydro (25%). The fiscal year 1984/85 represents the third year of operation of the project. In 1984/85, 108 contracts were awarded totalling $4 million. Supplementary funding by subcontractors added approximately $1.9 million to the total project value. More than 200 people participated in the technical work involved in the project. Sixteen people were on attachment to foreign facilities for terms ranging from 1 month to 2.5 years. Five patents were applied for including a tritium discrimination monitor, a new radio-chemical tritium separation method, a new variation of fuel cleanup by gas chromatography, a passive tritium permeation system using bimetallic membranes, and a new breeder process using lithium salts dissolved in heavy water

Airlie House Pollution Prevention Technology Transfer pilot projects

Energy Technology Data Exchange (ETDEWEB)

Thuot, J.R.; Myron, H.; Gatrone, R.; McHenry, J.

1996-08-01

The projects were a series of pilot projects developed for DOE with the intention of transferring pollution prevention technology to private industry. The concept was to develop small technology transfer initiatives in partnership with the private sector. Argonne National Laboratory developed three projects: the microscale chemistry in education program, the microscale cost benefit study, and the Bethel New Life recycling trainee program. The two microscale chemistry projects focused on introducing microscale chemistry technologies to secondary and college education. These programs were inexpensive to develop and received excellent evaluations from participants and regulators. The recycle trainee project provided training for two participants and identified recycling and source reduction opportunities in Argonne`s solid waste stream. The pilot projects demonstrated that technology transfer initiatives can be developed and implemented with a small budget and within a short period of time. The essential components of the pilot projects were identification of target technologies that were already available, identification of target audiences, and a focus of effort to achieve a limited but defined objective.

Demonstration Project 111, ITS/CVO Technology Truck, Final Project Report

Energy Technology Data Exchange (ETDEWEB)

Gambrell, KP

2002-01-11

In 1995, the planning and building processes began to design and develop a mobile demonstration unit that could travel across the nation and be used as an effective outreach tool. In 1997, the unit was completed; and from June 1997 until December 2000, the Federal Highway Administration (FHWA)/Federal Motor Carrier Safety Administration (FMCSA) mobilized the Technology Truck, also known as Demonstration Project No. 111, ''Advanced Motor Carrier Operations and Safety Technologies.'' The project featured the latest available state-of-the-practice intelligent transportation systems (ITS) technologies designed to improve both the efficiency and safety of commercial vehicle operations (CVO). The Technology Truck was designed to inform and educate the motor carrier community and other stakeholders regarding ITS technologies, thus gaining support and buy-in for participation in the ITS program. The primary objective of the project was to demonstrate new and emerging ITS/CVO technologies and programs, showing their impact on motor carrier safety and productivity. In order to meet the objectives of the Technology Truck project, the FHWA/FMCSA formed public/private partnerships with industry and with Oak Ridge National Laboratory to demonstrate and display available ITS/CVO technologies in a cooperative effort. The mobile demonstration unit was showcased at national and regional conferences, symposiums, universities, truck shows and other venues, in an effort to reach as many potential users and decision makers as possible. By the end of the touring phase, the ITS/CVO Technology Truck had been demonstrated in 38 states, 4 Canadian provinces, 88 cities, and 114 events; been toured by 18,099 people; and traveled 115,233 miles. The market penetration for the Technology Truck exceeded 4,000,000, and the website received more than 25,000 hits. In addition to the Truck's visits, the portable ITS/CVO kiosk was demonstrated at 31 events in 23 cites in 15

Canadian fusion fuels technology project

International Nuclear Information System (INIS)

1986-01-01

The Canadian Fusion Fuels Technology Project was launched in 1982 to coordinate Canada's provision of fusion fuels technology to international fusion power development programs. The project has a mandate to extend and adapt existing Canadian tritium technologies for use in international fusion power development programs. 1985-86 represents the fourth year of the first five-year term of the Canadian Fusion Fuels Technology Project (CFFTP). This reporting period coincides with an increasing trend in global fusion R and D to direct more effort towards the management of tritium. This has resulted in an increased linking of CFFTP activities and objectives with those of facilities abroad. In this way there has been a continuing achievement resulting from CFFTP efforts to have cooperative R and D and service activities with organizations abroad. All of this is aided by the cooperative international atmosphere within the fusion community. This report summarizes our past year and provides some highlights of the upcoming year 1986/87, which is the final year of the first five-year phase of the program. AECL (representing the Federal Government), the Ministry of Energy (representing Ontario) and Ontario Hydro, have given formal indication of their intent to continue with a second five-year program. Plans for the second phase will continue to emphasize tritium technology and remote handling

Barley lipid transfer protein, LTP1, contains a new type of lipid-like post-translational modification

DEFF Research Database (Denmark)

Lindorff-Larsen, Kresten; Lerche, Mathilde H.; Poulsen, Flemming Martin

2001-01-01

in which an aspartic acid in LTP1 is bound to the modification through what most likely is an ester bond. The chemical structure of the modification has been characterized by means of two-dimensional homo- and heteronuclear nuclear magnetic resonance spectroscopy as well as mass spectrometry and is found...

Technology Management on Large Construction Projects

DEFF Research Database (Denmark)

Bonke, Sten

The aim of this text is to discuss and to develop the concept of technology management in relation to the empirical field of construction projects. In the first of the two main sections central theories and their derived assertions concerning technology management criteria are summed up...... Fixed Link construction project. Finally on this basis the concluding remarks are pointing to the main theoretical problems and their practical implementations for the introduction of a technology management discipline in construction....... in a schematic theoretical framework. Hereafter the general characteristics of construction are examined from the point of view of serving as an empirical field for technology management analysis. In the second section the technology management theme is associated with the empirical properties of the Great Belt...

Moonlight project promotes energy-saving technology

Science.gov (United States)

Ishihara, A.

1986-01-01

In promoting energy saving, development of energy conservation technologies aimed at raising energy efficiency in the fields of energy conversion, its transportation, its storage, and its consumption is considered, along with enactment of legal actions urging rational use of energies and implementation of an enlightenment campaign for energy conservation to play a crucial role. Under the Moonlight Project, technical development is at present being centered around the following six pillars: (1) large scale energy saving technology; (2) pioneering and fundamental energy saving technology; (3) international cooperative research project; (4) research and survey of energy saving technology; (5) energy saving technology development by private industry; and (6) promotion of energy saving through standardization. Heat pumps, magnetohydrodynamic generators and fuel cells are discussed.

Project inspection using mobile technology - phase II : assessing the impacts of mobile technology on project inspection.

Science.gov (United States)

2015-01-01

As mobile technology becomes widely available and affordable, transportation agencies can use this : technology to streamline operations involved within project inspection. This research, conducted in two : phases, identified opportunities for proces...

Technology Base Research Project for electrochemical energy storage

Science.gov (United States)

Kinoshita, K.

1985-06-01

The DOE Electrochemical Energy Storage Program is divided into two projects: (1) the exploratory technology development and testing (ETD) project and (2) the technology base research (TBR) project. The role of the TBR Project is to perform supporting research for the advanced battery systems under development by the ETD Project, and to evaluate new systems with potentially superior performance, durability and/or cost characteristics. The specific goal of the TBR Project is to identify the most promising electrochemical technologies and transfer them to industry and/or the ETD Project for further development and scale-up. This report summarizes the research, financial, and management activities relevant to the TBR Project in CY 1984. General problem areas addressed by the project include identification of new electrochemical couples for advanced batteries, determination of technical feasibility of the new couples, improvements in battery components and materials, establishment of engineering principles applicable to electrochemical energy storage and conversion, and the assessment of fuel-cell technology for transportation applications. Major emphasis is given to applied research which will lead to superior performance and lower life-cycle costs. The TBR Project is divided into three major project elements: exploratory research, applied science research, and air systems research.

Kazakhstan innovation projects in nuclear technologies field

International Nuclear Information System (INIS)

Shkol'nik, V.S.; Tukhvatulin, Sh.T.

2005-01-01

At present in the Republic of Kazakhstan in preparation and realization stage there are several innovation projects related with use of advanced nuclear technologies. Projects are as follows: 'Implementation of Kazakhstan thermonuclear reactor tokamak (KTM)'; 'Implementation at the L.N. Gumilev Eurasian National University the inter-disciplinary research complex on the heavy ions accelerator base'; 'Development of the Technological Park 'Nuclear Technologies Center in Kurchatov city'; 'Development the first in the Central-Asian region Center of Nuclear Medicine and Biophysics'. The initiator and principal operator of these projects is the National Nuclear Center of the Republic of Kazakhstan

Ceramic technology for advanced heat engines project

Energy Technology Data Exchange (ETDEWEB)

1990-09-01

The Ceramic Technology for Advanced Heat Engines Project was developed by the Department of Energy's Office of Transportation Systems in Conservation and Renewable Energy. This project was developed to meet the ceramic technology requirements of the OTT's automotive technology programs. This project is managed by ORNL and is closely coordinated with complementary ceramics tasks funded by other DOE offices, NASA, DoD, and industry. Research is discussed under the following topics; Turbomilling of SiC Whiskers; microwave sintering of silicon nitride; and milling characterization; processing of monolithics; silicon nitride matrix; oxide matrix; silicate matrix; thermal and wear coatings; joining; design; contact interfaces; time-dependent behavior; environmental effects; fracture mechanics; nondestructive evaluation; and technology transfer. References, figures, and tables are included with each topic.

Elevation of endogenous anandamide impairs LTP, learning, and memory through CB1 receptor signaling in mice.

Science.gov (United States)

Basavarajappa, Balapal S; Nagre, Nagaraja N; Xie, Shan; Subbanna, Shivakumar

2014-07-01

In rodents, many exogenous and endogenous cannabinoids, such as anandamide (AEA) and 2-arachidonyl glycerol (2-AG), have been shown to play an important role in certain hippocampal memory processes. However, the mechanisms by which endogenous AEA regulate this processes are not well understood. Here the effects of AEA on long-term potentiation (LTP), hippocampal-dependent learning and memory tasks, pERK1/2, pCaMKIV, and pCREB signaling events in both cannabinoid receptor type 1 (CB1R) wild-type (WT) and knockout (KO) mice were assessed following administration of URB597, an inhibitor of the fatty acid amide hydrolase (FAAH). Acute administration of URB597 enhanced AEA levels without affecting the levels of 2-AG or CB1R in the hippocampus and neocortex as compared to vehicle. In hippocampal slices, URB597 impaired LTP in CB1R WT but not in KO littermates. URB597 impaired object recognition, spontaneous alternation and spatial memory in the Y-maze test in CB1R WT mice but not in KO mice. Furthermore, URB597 enhanced ERK phosphorylation in WT without affecting total ERK levels in WT or KO mice. URB597 impaired CaMKIV and CREB phosphorylation in WT but not in KO mice. CB1R KO mice have a lower pCaMKIV/CaMKIV ratio and higher pCREB/CREB ratio as compared to WT littermates. Our results indicate that pharmacologically elevated AEA impair LTP, learning and memory and inhibit CaMKIV and CREB phosphorylation, via the activation of CB1Rs. Collectively, these findings also suggest that pharmacological elevation of AEA beyond normal concentrations is also detrimental for the underlying physiological responses. © 2014 Wiley Periodicals, Inc.

Key Issues in Global Technological Innovation Projects

Directory of Open Access Journals (Sweden)

Roberto Sbragia

2012-04-01

Full Text Available This article aimed to identify those issues that were present in global technological innovation projects carried out by Brazilian multinational companies and which performance criterions these undertakings met. We investigated 36 global technological innovation projects from Brazilian multinational enterprises through a web-survey. Findings show that these companies went beyond the traditional iron triangle to evaluate their technological efforts and considered additional performance dimensions such as customer satisfaction, business results, and preparation for the future. Results also show high degree of presence for issues emerging from the industry, moderate degree of presence for issues emerging from both the project and R&D activities, and low degree of presence for issues emerging from the headquarters, the subsidiaries, and the external environment. Further research is needed to find out if and how these issues influenced the performance of the global technological innovation projects studied.DOI:10.5585/gep.v3i1.72

Comprehensive assessment of the status scientific and technical projects using Technology Project Readiness Level

Directory of Open Access Journals (Sweden)

A. N. Petrov

2016-01-01

Full Text Available The balanced methodology for assessing the Technology Project Readiness Level for commercialization (TPRL is proposed. TPRL allows to determine the dynamics and balance of development projects that use the standardized approaches used in assessing the readiness of the technology. Validation of the methodology undertaken for the projects of Federal target programs “Research and development on priority directions of development of scientific-technological complex of Russia for 2007–2013” and “Research and development on priority directions of development of scientific-technological complex of Russia for 2014–2020”. The obtained results showed the possibility of application of the methodology for the evaluation of projects, improving efficiency of expert activity in the evaluation of projects, monitoring the status of individual project and group of projects (portfolio. The application of the methodology allowed us to improve the management of individual project and portfolio of projects.Methodology TPRL will allow the implementers, industry partners, investors, and innovative industrial companies to improve the efficiency of its activities.

The Canadian Fusion Fuels Technology Project

International Nuclear Information System (INIS)

Dautovich, D.P.; Gierszewski, P.J.; Wong, K.Y.; Stasko, R.R.; Burnham, C.D.

1987-04-01

The Canadian Fusion Fuels Technology Project (CFFTP) is a national project whose aim is to develop capability in tritium and robotics technologies for application to international fusion development programs. Activities over the first five years have brought substantial interaction with the world's leading projects such as Tokamak Fusion Test Reactor (TFTR), the Joint European Torus (JET), and the Next European Torus (NET), Canadian R and D and engineering services, and hardware are in demand as these major projects prepare for tritium operation leading to the demonstration of energy breakeven around 1990. Global planning is underway for the next generation ignition experiment. It is anticipated this will provide increased opportunity for CFFTP and its contractors among industry, universities and governmental laboratories

Korea-China Optical Technology Research Centre Project

International Nuclear Information System (INIS)

Kim, Cheol Jung; Rhee, Y. J.; Jung, D. Y. and others

2004-06-01

The main objectives of this project are to establish the international collaboration basis of optical technologies between Korea and China. The combination of the Chinese advanced fundamental technologies with the Korean industrialization and commercialization infrastructures is realized, by ways of exchanging scientists and informations, holding joint seminars, cooperative utilization of research resources. On the ground of this establishment, the optical technologies of Korea are supposed to be leveled up to those of the world-most advanced. At the same time, for the improvement of mutual benefit and financial profit of both countries, providing technical advice and suggestions to the optical industries in the two countries is an another goal of this project. The state-of-the-arts of the Chinese technologies such as aerospace engineering, military defence technology, medical technology, laser fusion research, and so on, are known to be far above those of Korean and up to one of the most advanced in the world. Thus it is thought to be necessary that the acquisition of these technologies, implementation of joint research projects for technology development as well as the balanced opportunities for commercial product/sales and cooperation should be actively pursued in order to enhance the levels of Korean technologies in these fields

Korea-China Optical Technology Research Centre Project

Energy Technology Data Exchange (ETDEWEB)

Kim, Cheol Jung; Rhee, Y. J.; Jung, D. Y. and others

2004-06-15

The main objectives of this project are to establish the international collaboration basis of optical technologies between Korea and China. The combination of the Chinese advanced fundamental technologies with the Korean industrialization and commercialization infrastructures is realized, by ways of exchanging scientists and informations, holding joint seminars, cooperative utilization of research resources. On the ground of this establishment, the optical technologies of Korea are supposed to be leveled up to those of the world-most advanced. At the same time, for the improvement of mutual benefit and financial profit of both countries, providing technical advice and suggestions to the optical industries in the two countries is an another goal of this project. The state-of-the-arts of the Chinese technologies such as aerospace engineering, military defence technology, medical technology, laser fusion research, and so on, are known to be far above those of Korean and up to one of the most advanced in the world. Thus it is thought to be necessary that the acquisition of these technologies, implementation of joint research projects for technology development as well as the balanced opportunities for commercial product/sales and cooperation should be actively pursued in order to enhance the levels of Korean technologies in these fields.

The Revolutionary Vertical Lift Technology (RVLT) Project

Science.gov (United States)

Yamauchi, Gloria K.

2018-01-01

The Revolutionary Vertical Lift Technology (RVLT) Project is one of six projects in the Advanced Air Vehicles Program (AAVP) of the NASA Aeronautics Research Mission Directorate. The overarching goal of the RVLT Project is to develop and validate tools, technologies, and concepts to overcome key barriers for vertical lift vehicles. The project vision is to enable the next generation of vertical lift vehicles with aggressive goals for efficiency, noise, and emissions, to expand current capabilities and develop new commercial markets. The RVLT Project invests in technologies that support conventional, non-conventional, and emerging vertical-lift aircraft in the very light to heavy vehicle classes. Research areas include acoustic, aeromechanics, drive systems, engines, icing, hybrid-electric systems, impact dynamics, experimental techniques, computational methods, and conceptual design. The project research is executed at NASA Ames, Glenn, and Langley Research Centers; the research extensively leverages partnerships with the US Army, the Federal Aviation Administration, industry, and academia. The primary facilities used by the project for testing of vertical-lift technologies include the 14- by 22-Ft Wind Tunnel, Icing Research Tunnel, National Full-Scale Aerodynamics Complex, 7- by 10-Ft Wind Tunnel, Rotor Test Cell, Landing and Impact Research facility, Compressor Test Facility, Drive System Test Facilities, Transonic Turbine Blade Cascade Facility, Vertical Motion Simulator, Mobile Acoustic Facility, Exterior Effects Synthesis and Simulation Lab, and the NASA Advanced Supercomputing Complex. To learn more about the RVLT Project, please stop by booth #1004 or visit their website at https://www.nasa.gov/aeroresearch/programs/aavp/rvlt.

Ceramic Technology for Advanced Heat Engines Project

Energy Technology Data Exchange (ETDEWEB)

1990-08-01

The Ceramic Technology For Advanced Heat Engines Project was developed by the Department of Energy's Office of Transportation Systems (OTS) in Conservation and Renewable Energy. This project, part of the OTS's Advanced Materials Development Program, was developed to meet the ceramic technology requirements of the OTS's automotive technology programs. Significant accomplishments in fabricating ceramic components for the Department of Energy (DOE), National Aeronautics and Space Administration (NASA), and Department of Defense (DOD) advanced heat engine programs have provided evidence that the operation of ceramic parts in high-temperature engine environments is feasible. However, these programs have also demonstrated that additional research is needed in materials and processing development, design methodology, and data base and life prediction before industry will have a sufficient technology base from which to produce reliable cost-effective ceramic engine components commercially. An assessment of needs was completed, and a five year project plan was developed with extensive input from private industry. The objective of the project is to develop the industrial technology base required for reliable ceramics for application in advanced automotive heat engines. The project approach includes determining the mechanisms controlling reliability, improving processes for fabricating existing ceramics, developing new materials with increased reliability, and testing these materials in simulated engine environments to confirm reliability. Although this is a generic materials project, the focus is on structural ceramics for advanced gas turbine and diesel engines, ceramic hearings and attachments, and ceramic coatings for thermal barrier and wear applications in these engines.

Clean Coal Technology Programs: Completed Projects (Volume 2)

Energy Technology Data Exchange (ETDEWEB)

Assistant Secretary for Fossil Energy

2003-12-01

Annual report on the Clean Coal Technology Demonstration Program (CCTDP), Power Plant Improvement Initiative (PPII), and Clean Coal Power Initiative (CCPI). The report addresses the roles of the programs, implementation, funding and costs, project descriptions, legislative history, program history, environmental aspects, and project contacts. The project descriptions describe the technology and provides a brief summary of the demonstration results.

NASA's Exploration Technology Development Program Energy Storage Project Battery Technology Development

Science.gov (United States)

Reid, Concha M.; Miller, Thomas B.; Mercer, Carolyn R.; Jankovsky, Amy L.

2010-01-01

Technical Interchange Meeting was held at Saft America s Research and Development facility in Cockeysville, Maryland on Sept 28th-29th, 2010. The meeting was attended by Saft, contractors who are developing battery component materials under contracts awarded through a NASA Research Announcement (NRA), and NASA. This briefing presents an overview of the components being developed by the contractor attendees for the NASA s High Energy (HE) and Ultra High Energy (UHE) cells. The transition of the advanced lithium-ion cell development project at NASA from the Exploration Technology Development Program Energy Storage Project to the Enabling Technology Development and Demonstration High Efficiency Space Power Systems Project, changes to deliverable hardware and schedule due to a reduced budget, and our roadmap to develop cells and provide periodic off-ramps for cell technology for demonstrations are discussed. This meeting gave the materials and cell developers the opportunity to discuss the intricacies of their materials and determine strategies to address any particulars of the technology.

On-orbit alignment and diagnostics for the LISA Technology Package

International Nuclear Information System (INIS)

MarIn, A F GarcIa; Wand, V; Steier, F; Cervantes, F Guzman; Bogenstahl, J; Jennrich, O; Heinzel, G; Danzmann, K

2006-01-01

This paper presents a procedure to perform fully autonomous on-orbit alignment of the interferometer on board the LISA Technology Package (LTP). LTP comprises two free-floating test masses as inertial sensors that additionally serve as end mirrors of a set of interferometers. From the output signals of the interferometers, a subset has been selected to obtain alignment information of the test masses. Based on these signals, an alignment procedure was developed and successfully tested on the engineering model of the optical bench. Furthermore, operation procedures for the characterization of critical on-orbit properties of the optical metrology system (e.g. fibre noise) have been established

NMDA receptor subunits in the adult rat hippocampus undergo similar changes after 5 minutes in an open field and after LTP induction.

Directory of Open Access Journals (Sweden)

Maria Veronica Baez

Full Text Available NMDA receptor subunits change during development and their synaptic expression is modified rapidly after synaptic plasticity induction in hippocampal slices. However, there is scarce information on subunits expression after synaptic plasticity induction or memory acquisition, particularly in adults. GluN1, GluN2A and GluN2B NMDA receptor subunits were assessed by western blot in 1 adult rats that had explored an open field (OF for 5 minutes, a time sufficient to induce habituation, 2 mature rat hippocampal neuron cultures depolarized by KCl and 3 hippocampal slices from adult rats where long term potentiation (LTP was induced by theta-burst stimulation (TBS. GluN1 and GluN2A, though not GluN2B, were significantly higher 70 minutes--but not 30 minutes--after a 5 minutes session in an OF. GluN1 and GluN2A total immunofluorescence and puncta in neurites increased in cultures, as evaluated 70 minutes after KCl stimulation. Similar changes were found in hippocampal slices 70 minutes after LTP induction. To start to explore underlying mechanisms, hippocampal slices were treated either with cycloheximide (a translation inhibitor or actinomycin D (a transcription inhibitor during electrophysiological assays. It was corroborated that translation was necessary for LTP induction and expression. The rise in GluN1 depends on transcription and translation, while the increase in GluN2A appears to mainly depend on translation, though a contribution of some remaining transcriptional activity during actinomycin D treatment could not be rouled out. LTP effective induction was required for the subunits to increase. Although in the three models same subunits suffered modifications in the same direction, within an apparently similar temporal course, further investigation is required to reveal if they are related processes and to find out whether they are causally related with synaptic plasticity, learning and memory.

Korea-China optical technology research centre project

Energy Technology Data Exchange (ETDEWEB)

Kim, Cheol Jung; Lee, J M; Rhee, Y J. and others

2001-09-01

The main objectives of this project are to establish the internatinal collaboration basis of optical technolgies between Korean and China through the combination of the Chinese advanced fundamental technologies with the Korea industrialization and commercialization infrastructures, by ways of exchanging scientist and informations, holding joint seminars, cooperative utilization of research resources. On the ground of this establishment, the optical technologies of Korea are supposed to be leveled up to that of the world-most advanced. At the same time, for the improvement of mutual benefit and financial profit of both of the countries, technical support for the investment on the optical industries in the two countries and establishment of foundation for the venture capitals are also the purpose of this project. Because the state-of-the-arts of the Chinese technologies such as aerospace engineering, military defense technology, applications to medical treatments, laser fusion research, and so on, are known to be far above those of Korean and upto one of the most advanced in the world, it is necessary that the acquisition of these technologies, resulting in the enhancement of the levels of domestic technologies in these fields, implementation of joint research projects for technology development as well as the balanced opportunities for commercial product/sales and cooperation should be actively pursued.

Korea-China optical technology research centre project

International Nuclear Information System (INIS)

Kim, Cheol Jung; Lee, J. M.; Rhee, Y. J. and others

2001-09-01

The main objectives of this project are to establish the internatinal collaboration basis of optical technolgies between Korean and China through the combination of the Chinese advanced fundamental technologies with the Korea industrialization and commercialization infrastructures, by ways of exchanging scientist and informations, holding joint seminars, cooperative utilization of research resources. On the ground of this establishment, the optical technologies of Korea are supposed to be leveled up to that of the world-most advanced. At the same time, for the improvement of mutual benefit and financial profit of both of the countries, technical support for the investment on the optical industries in the two countries and establishment of foundation for the venture capitals are also the purpose of this project. Because the state-of-the-arts of the Chinese technologies such as aerospace engineering, military defense technology, applications to medical treatments, laser fusion research, and so on, are known to be far above those of Korean and upto one of the most advanced in the world, it is necessary that the acquisition of these technologies, resulting in the enhancement of the levels of domestic technologies in these fields, implementation of joint research projects for technology development as well as the balanced opportunities for commercial product/sales and cooperation should be actively pursued

Project Management Plan for the INEL technology logic diagrams

International Nuclear Information System (INIS)

Rudin, M.J.

1992-10-01

This Project Management Plan (PjMP) describes the elements of project planning and control that apply to activities outlined in Technical Task Plan (TTP) ID-121117, ''Technology Logic Diagrams For The INEL.'' The work on this project will be conducted by personnel in EG ampersand G Idaho, Inc.'s Waste Technology Development Program. Technology logic diagrams represent a formal methodology to identify technology gaps or needs within Environmental Restoration/Waste Management Operations, which will focus on Office of Environmental Restoration and Waste Management (EM-50) research and development, demonstration, test, and evaluation efforts throughout the US Department of Energy complex. This PjMP describes the objectives, organization, roles and responsibilities, workscope and processes for implementing and managing the technology logic diagram for the Idaho National Engineering Laboratory project

Construction Project Performance Improvement through Radio Frequency Identification Technology Application on a Project Supply Chain

Science.gov (United States)

Wang, Heng

2017-01-01

Construction project productivity typically lags other industries and it has been the focus of numerous studies in order to improve the project performance. This research investigated the application of Radio Frequency Identification (RFID) technology on construction projects' supply chain and determined that RFID technology can improve the…

Waste minimization and pollution prevention technology transfer : the Airlie House Projects

International Nuclear Information System (INIS)

Gatrone, R.; McHenry, J.; Myron, H.; Thout, J. R.

1998-01-01

The Airlie House Pollution Prevention Technology Transfer Projects were a series of pilot projects developed for the US Department of Energy with the intention of transferring pollution prevention technology to the private sector. The concept was to develop small technology transfer initiatives in partnership with the private sector. Argonne National Laboratory developed three projects: the microscale chemistry in education project, the microscale cost benefit study project, and the Bethel New Life recycling trainee project. The two microscale chemistry projects focused on introducing microscale chemistry technologies to secondary and college education. These programs were inexpensive to develop and received excellent evaluations from participants and regulators. The Bethel New Life recycling trainee project provided training for two participants who helped identify recycling and source reduction opportunities in Argonne National Laboratory's solid waste stream. The pilot projects demonstrated that technology transfer initiatives can be developed and implemented with a small budget and within a short period of time. The essential components of the pilot projects were identifying target technologies that were already available, identifying target audiences, and focusing on achieving a limited but defined objective

Human genome project: revolutionizing biology through leveraging technology

Science.gov (United States)

Dahl, Carol A.; Strausberg, Robert L.

1996-04-01

The Human Genome Project (HGP) is an international project to develop genetic, physical, and sequence-based maps of the human genome. Since the inception of the HGP it has been clear that substantially improved technology would be required to meet the scientific goals, particularly in order to acquire the complete sequence of the human genome, and that these technologies coupled with the information forthcoming from the project would have a dramatic effect on the way biomedical research is performed in the future. In this paper, we discuss the state-of-the-art for genomic DNA sequencing, technological challenges that remain, and the potential technological paths that could yield substantially improved genomic sequencing technology. The impact of the technology developed from the HGP is broad-reaching and a discussion of other research and medical applications that are leveraging HGP-derived DNA analysis technologies is included. The multidisciplinary approach to the development of new technologies that has been successful for the HGP provides a paradigm for facilitating new genomic approaches toward understanding the biological role of functional elements and systems within the cell, including those encoded within genomic DNA and their molecular products.

LTP in Hippocampal Area CA1 Is Induced by Burst Stimulation over a Broad Frequency Range Centered around Delta

Science.gov (United States)

Grover, Lawrence M.; Kim, Eunyoung; Cooke, Jennifer D.; Holmes, William R.

2009-01-01

Long-term potentiation (LTP) is typically studied using either continuous high-frequency stimulation or theta burst stimulation. Previous studies emphasized the physiological relevance of theta frequency; however, synchronized hippocampal activity occurs over a broader frequency range. We therefore tested burst stimulation at intervals from 100…

Canadian Fusion Fuels Technology Project annual report 93/94

Energy Technology Data Exchange (ETDEWEB)

NONE

1994-12-31

The Canadian Fusion Fuels Technology Project exists to develop fusion technologies and apply them worldwide in today`s advanced fusion projects and to apply these technologies in fusion and tritium research facilities. CFFTP concentrates on developing capability in fusion fuel cycle systems, in tritium handling technologies and in remote handling. This is an annual report for CFFTP and as such also includes a financial report.

Canadian Fusion Fuels Technology Project annual report 93/94

International Nuclear Information System (INIS)

1994-01-01

The Canadian Fusion Fuels Technology Project exists to develop fusion technologies and apply them worldwide in today's advanced fusion projects and to apply these technologies in fusion and tritium research facilities. CFFTP concentrates on developing capability in fusion fuel cycle systems, in tritium handling technologies and in remote handling. This is an annual report for CFFTP and as such also includes a financial report

Costs and Benefits of a Shared Digital Long-Term Preservation System

Directory of Open Access Journals (Sweden)

Esa-Pekka Keskitalo

2011-10-01

Full Text Available This paper describes the cost-benefit analysis of digital long-term preservation (LTP that was carried out in the context of the Finnish National Digital Library Project (NDL in 2010. The analysis was based on the assumption that as many as 200 archives, libraries, and museums will share an LTP system. The term ‘system’ shall be understood as encompassing not only information technology, but also human resources, organizational structures, policies and funding mechanisms. The cost analysis shows that an LTP system will incur, over the first 12 years, cumulative costs of €42 million, i.e. an average of €3.5 million per annum. Human resources and investments in information technology are the major cost factors. After the initial stages, the analysis predicts annual costs of circa €4 million. The analysis compared scenarios with and without a shared LTP system. The results indicate that a shared system will have remarkable benefits. At the development and implementation stages, a shared system shows an advantage of €30 million against the alternative scenario consisting of five independent LTP solutions. During the later stages, the advantage is estimated at €10 million per annum. The cumulative cost benefit over the first 12 years would amount to circa €100 million.

The Columbia River Protection Supplemental Technologies Quality Assurance Project Plan

Energy Technology Data Exchange (ETDEWEB)

Fix, N. J.

2008-03-12

Pacific Northwest National Laboratory researchers are working on the Columbia River Protection Supplemental Technologies Project. This project is a U. S. Department of Energy, Office of Environmental Management-funded initiative designed to develop new methods, strategies, and technologies for characterizing, modeling, remediating, and monitoring soils and groundwater contaminated with metals, radionuclides, and chlorinated organics. This Quality Assurance Project Plan provides the quality assurance requirements and processes that will be followed by the Technologies Project staff.

INFORMATION TECHNOLOGY IN INVESTMENT PROJECT MANAGEMENT

Directory of Open Access Journals (Sweden)

Vjacheslav A. Kozlov

2014-01-01

Full Text Available In the article it is proved that use of information technology today is not only something innovative distinctive feature and competitive advantage for organizations, but it is a necessary condition for effective business. The article discusses the main functionality of financial-analytical system Project Expert as an effective tool of investment project management and instrument of business planning. The main advantages which organizations get from Project Expert program use are in detail considered. Thus in the article Project Expert is considered as the effective tool of investment project management which allows to receive a number of advantages and to carry out the qualitative analysis of projects.

A Correlational Study Assessing the Relationships among Information Technology Project Complexity, Project Complication, and Project Success

Science.gov (United States)

Williamson, David J.

2011-01-01

The specific problem addressed in this study was the low success rate of information technology (IT) projects in the U.S. Due to the abstract nature and inherent complexity of software development, IT projects are among the most complex projects encountered. Most existing schools of project management theory are based on the rational systems…

Incorporating the Technology Roadmap Uncertainties into the Project Risk Assessment

International Nuclear Information System (INIS)

Bonnema, B.E.

2002-01-01

This paper describes two methods, Technology Roadmapping and Project Risk Assessment, which were used to identify and manage the technical risks relating to the treatment of sodium bearing waste at the Idaho National Engineering and Environmental Laboratory. The waste treatment technology under consideration was Direct Vitrification. The primary objective of the Technology Roadmap is to identify technical data uncertainties for the technologies involved and to prioritize the testing or development studies to fill the data gaps. Similarly, project management's objective for a multi-million dollar construction project includes managing all the key risks in accordance to DOE O 413.3 - ''Program and Project Management for the Acquisition of Capital Assets.'' In the early stages, the Project Risk Assessment is based upon a qualitative analysis for each risk's probability and consequence. In order to clearly prioritize the work to resolve the technical issues identified in the Technology Roadmap, the issues must be cross- referenced to the project's Risk Assessment. This will enable the project to get the best value for the cost to mitigate the risks

Glutamate Receptor GluA1 Subunit Is Implicated in Capsaicin Induced Modulation of Amygdala LTP but Not LTD

Science.gov (United States)

Gebhardt, Christine; Albrecht, Doris

2018-01-01

Capsaicin has been shown to modulate synaptic plasticity in various brain regions including the amygdala. Whereas in the lateral amygdala the modulatory effect of capsaicin on long-term potentiation (LA-LTP) is mediated by TRPV1 channels, we have recently shown that capsaicin-induced enhancement of long term depression (LA-LTD) is mediated by…

Financing innovative technologies in wind projects

International Nuclear Information System (INIS)

Vaughan, C.

2006-01-01

Methods of market entry and the financing of new technologies were discussed from the perspective of Clipper Windpower, a wind energy company based in the northeastern United States and Canada. Many new technology companies only consider private equity when seeking financing for new product development. However, financing for projects and products is only the first step to market entry. Wind projects are the financial equivalent of a high yield bond with mechanical risk. Many wind power projects with company equity can also be seen as a long term bond with upside in any given year. It is therefore important for wind developers to seek out strategic buyers for both product development and project development, in addition to finding sources of private equity. Clipper Windpower Inc. has developed a partnership with British Petroleum (BP), who hold an equity interest in the company. Both companies are now partnering on projects with Clipper turbines, and firm orders are in place for 2007 and 2008. As a result of the partnership, Clipper now has increased its financial strength in cash flows, balance sheets, and projected revenue. It was concluded that a successful partnership can increase the scale of wind power development, and bring financial sophistication to smaller companies with limited resources. refs., tabs., figs

The Columbia River Protection Supplemental Technologies Quality Assurance Project Plan

International Nuclear Information System (INIS)

Fix, Anne

2007-01-01

The U.S. Department of Energy (DOE) has conducted interim groundwater remedial activities on the Hanford Site since the mid-1990s for several groundwater contamination plumes. DOE established the Columbia River Protection Supplemental Technologies Project (Technologies Project) in 2006 to evaluate alternative treatment technologies. The objectives for the technology project are as follows: develop a 300 Area polyphosphate treatability test to immobilize uranium, design and test infiltration of a phosphate/apatite technology for Sr-90 at 100-N, perform carbon tetrachloride and chloroform attenuation parameter studies, perform vadose zone chromium characterization and geochemistry studies, perform in situ biostimulation of chromium studies for a reducing barrier at 100-D, and perform a treatability test for phytoremediation for Sr-90 at 100-N. This document provides the quality assurance guidelines that will be followed by the Technologies Project. This Quality Assurance Project Plan is based on the quality assurance requirements of DOE Order 414.1C, Quality Assurance, and 10 CFR 830, Subpart A--Quality Assurance Requirements as delineated in Pacific Northwest National Laboratory?s Standards-Based Management System. In addition, the technology project is subject to the Environmental Protection Agency (EPA) Requirements for Quality Assurance Project Plans (EPA/240/B-01/003, QA/R-5). The Hanford Analytical Services Quality Assurance Requirements Documents (HASQARD, DOE/RL-96-68) apply to portions of this project and to the subcontractors. HASQARD requirements are discussed within applicable sections of this plan.

NF-κB p50 subunit knockout impairs late LTP and alters long term memory in the mouse hippocampus

Directory of Open Access Journals (Sweden)

Oikawa Kensuke

2012-07-01

Full Text Available Abstract Background Nuclear factor kappa B (NF-κB is a transcription factor typically expressed with two specific subunits (p50, p65. Investigators have reported that NF-κB is activated during the induction of in vitro long term potentiation (LTP, a paradigm of synaptic plasticity and correlate of memory, suggesting that NF-κB may be necessary for some aspects of memory encoding. Furthermore, NF-κB has been implicated as a potential requirement in behavioral tests of memory. Unfortunately, very little work has been done to explore the effects of deleting specific NF-κB subunits on memory. Studies have shown that NF-κB p50 subunit deletion (p50−/− leads to memory deficits, however some recent studies suggest the contrary where p50−/− mice show enhanced memory in the Morris water maze (MWM. To more critically explore the role of the NF-κB p50 subunit in synaptic plasticity and memory, we assessed long term spatial memory in vivo using the MWM, and synaptic plasticity in vitro utilizing high frequency stimuli capable of eliciting LTP in slices from the hippocampus of NF-κB p50−/− versus their controls (p50+/+. Results We found that the lack of the NF-κB p50 subunit led to significant decreases in late LTP and in selective but significant alterations in MWM tests (i.e., some improvements during acquisition, but deficits during retention. Conclusions These results support the hypothesis that the NF-κ p50 subunit is required in long term spatial memory in the hippocampus.

Deficits in LTP induction by 5-HT2A receptor antagonist in a mouse model for fragile X syndrome.

Directory of Open Access Journals (Sweden)

Zhao-hui Xu

Full Text Available Fragile X syndrome is a common inherited form of mental retardation caused by the lack of fragile X mental retardation protein (FMRP because of Fmr1 gene silencing. Serotonin (5-HT is significantly increased in the null mutants of Drosophila Fmr1, and elevated 5-HT brain levels result in cognitive and behavioral deficits in human patients. The serotonin type 2A receptor (5-HT2AR is highly expressed in the cerebral cortex; it acts on pyramidal cells and GABAergic interneurons to modulate cortical functions. 5-HT2AR and FMRP both regulate synaptic plasticity. Therefore, the lack of FMRP may affect serotoninergic activity. In this study, we determined the involvement of FMRP in the 5-HT modulation of synaptic potentiation with the use of primary cortical neuron culture and brain slice recording. Pharmacological inhibition of 5-HT2AR by R-96544 or ketanserin facilitated long-term potentiation (LTP in the anterior cingulate cortex (ACC of WT mice. The prefrontal LTP induction was dependent on the activation of NMDARs and elevation of postsynaptic Ca(2+ concentrations. By contrast, inhibition of 5-HT2AR could not restore the induction of LTP in the ACC of Fmr1 knock-out mice. Furthermore, 5-HT2AR inhibition induced AMPA receptor GluR1 subtype surface insertion in the cultured ACC neurons of Fmr1 WT mice, however, GluR1 surface insertion by inhibition of 5-HT2AR was impaired in the neurons of Fmr1KO mice. These findings suggested that FMRP was involved in serotonin receptor signaling and contributed in GluR1 surface expression induced by 5-HT2AR inactivation.

INFORMATION TECHNOLOGIES IN MANAGEMENT OF ENERGY SAVING PROJECTS

Directory of Open Access Journals (Sweden)

Дмитро Валерійович МАРГАСОВ

2015-06-01

Full Text Available The information technology structure is considered of energy saving projects. The project management diagram of energy saving projects is developed, using GIS, ICS, BIM and other control and visual systems.

D1/D5 Receptors and Histone Deacetylation Mediate the Gateway Effect of LTP in Hippocampal Dentate Gyrus

Science.gov (United States)

Huang, Yan-You; Lavine, Amir; Kandel, Denise B.; Yin, Deqi; Colnaghi, Luca; Drisaldi, Bettina; Kandel, Eric R.

2014-01-01

The dentate gyrus (DG) of the hippocampus is critical for spatial memory and is also thought to be involved in the formation of drug-related associative memory. Here, we attempt to test an aspect of the Gateway Hypothesis, by studying the effect of consecutive exposure to nicotine and cocaine on long-term synaptic potentiation (LTP) in the DG. We…

Ceramic technology for Advanced Heat Engines Project

Energy Technology Data Exchange (ETDEWEB)

Johnson, D.R.

1991-07-01

Significant accomplishments in fabricating ceramic components for advanced heat engine programs have provided evidence that the operation of ceramic parts in high-temperature engine environments is feasible. However, these programs have also demonstrated that additional research is needed in materials and processing development, design methodology, and database and life prediction before industry will have a sufficient technology base from which to produce reliable cost-effective ceramic engine components commercially. An assessment of needs was completed, and a five year project plan was developed with extensive input from private industry. The project approach includes determining the mechanisms controlling reliability, improving processes for fabricating existing ceramics, developing new materials with increased reliability, and testing these materials in simulated engine environments to confirm reliability. Although this is a generic materials project, the focus is on the structural ceramics for advanced gas turbine and diesel engines, ceramic bearings and attachments, and ceramic coatings for thermal barrier and wear applications in these engines. To facilitate the rapid transfer of this technology to US industry, the major portion of the work is being done in the ceramic industry, with technological support from government laboratories, other industrial laboratories, and universities. This project is managed by ORNL for the Office of Transportation Technologies, Office of Transportation Materials, and is closely coordinated with complementary ceramics tasks funded by other DOE offices, NASA, DOD, and industry.

Enhanced sensitivity to ethanol-induced inhibition of LTP in CA1 pyramidal neurons of socially isolated C57BL/6J mice: role of neurosteroids

Directory of Open Access Journals (Sweden)

Giuseppe eTalani

2011-10-01

Full Text Available Ethanol (EtOH–induced impairment of long-term potentiation (LTP in the rat hippocampus is prevented by the 5α-reductase inhibitor finasteride, suggesting that this effect of EtOH is dependent on the increased local release of neurosteroids such as 3α,5α-THP that promote GABA–mediated transmission. Given that social isolation (SI in rodents is associated with altered plasma and brain levels of such neurosteroids as well as with an enhanced neurosteroidogenic action of EtOH, we examined whether the inhibitory effect of EtOH on LTP at CA3-CA1 hippocampal excitatory synapses is altered in C57BL/6J mice subjected to SI for 6 weeks in comparison with group-housed (GH animals. Extracellular recording of fEPSPs as well as patch-clamp analysis were performed in hippocampal slices prepared from both SI and GH mice. Consistent with previous observations, recording of fEPSPs revealed that the extent of LTP induced in the CA1 region of SI mice was significantly reduced compared with that in GH animals. EtOH (40 mM inhibited LTP in slices from SI mice but not in those from GH mice, and this effect of EtOH was abolished by co-application of 1 µM finasteride. Current-clamp analysis of CA1 pyramidal neurons revealed a decrease in action potential frequency and an increase in the intensity of injected current required to evoke the first action potential in SI mice compared with GH mice, indicative of a decrease in neuronal excitability associated with SI. Together, our data suggest that SI results in reduced levels of neuronal excitability and synaptic plasticity in the hippocampus. Furthermore, the increased sensitivity to the neurosteroidogenic effect of EtOH associated with SI likely accounts for the greater inhibitory effect of EtOH on LTP in SI mice. The increase in EtOH sensitivity induced by SI may be important for the changes in the effects of EtOH on anxiety and on learning and memory associated with the prolonged stress attributable to social

The Role of the Project Management Office on Information Technology Project Success

Science.gov (United States)

Stewart, Jacob S.

2010-01-01

The rate of failed and challenged Information Technology (IT) projects is too high according to the CHAOS Studies by the Standish Group and the literature on project management (Standish Group, 2008). The CHAOS Studies define project success as meeting the triple constraints of scope, time, and cost. Assessing critical success factors is another…

Projection display technologies for the new millennium

Science.gov (United States)

Kahn, Frederic J.

2000-04-01

Although analog CRTs continue to enable most of the world's electronic projection displays such as US consumer rear projection televisions, discrete pixel (digital) active matrix LCD and DLP reflective mirror array projectors have rapidly created large nonconsumer markets--primarily for business. Recent advances in image quality, compactness and cost effectiveness of digital projectors have the potential to revolutionize major consumer and entertainment markets as well. Digital penetration of the mainstream consumer projection TV market will begin in the hear 2000. By 2005 digital projection HDTVs could take the major share of the consumer HDTV projection market. Digital projection is expected to dominate both the consumer HDTV and the cinema market by 2010, resulting in potential shipments for all projection markets exceeding 10 M units per year. Digital projection is improving at a rate 10X faster than analog CRT projectors and 5X faster than PDP flat panels. Continued rapid improvement of digital projection is expected due to its relative immaturity and due to the wide diversity of technological improvements being pursued. Key technology enablers are the imaging panels, light sources and micro-optics. Market shares of single panel projectors, MEMs panels, LCOS panels and low T p-Si TFT LCD panel variants are expected to increase.

Advanced Turbine Technology Applications Project (ATTAP)

Science.gov (United States)

1994-01-01

Reports technical effort by AlliedSignal Engines in sixth year of DOE/NASA funded project. Topics include: gas turbine engine design modifications of production APU to incorporate ceramic components; fabrication and processing of silicon nitride blades and nozzles; component and engine testing; and refinement and development of critical ceramics technologies, including: hot corrosion testing and environmental life predictive model; advanced NDE methods for internal flaws in ceramic components; and improved carbon pulverization modeling during impact. ATTAP project is oriented toward developing high-risk technology of ceramic structural component design and fabrication to carry forward to commercial production by 'bridging the gap' between structural ceramics in the laboratory and near-term commercial heat engine application. Current ATTAP project goal is to support accelerated commercialization of advanced, high-temperature engines for hybrid vehicles and other applications. Project objectives are to provide essential and substantial early field experience demonstrating ceramic component reliability and durability in modified, available, gas turbine engine applications; and to scale-up and improve manufacturing processes of ceramic turbine engine components and demonstrate application of these processes in the production environment.

Collaborative Project-Based Learning: An Integrative Science and Technological Education Project

Science.gov (United States)

Baser, Derya; Ozden, M. Yasar; Karaarslan, Hasan

2017-01-01

Background: Blending collaborative learning and project-based learning (PBL) based on Wolff (2003) design categories, students interacted in a learning environment where they developed their technology integration practices as well as their technological and collaborative skills. Purpose: The study aims to understand how seventh grade students…

Projection display technology for avionics applications

Science.gov (United States)

Kalmanash, Michael H.; Tompkins, Richard D.

2000-08-01

Avionics displays often require custom image sources tailored to demanding program needs. Flat panel devices are attractive for cockpit installations, however recent history has shown that it is not possible to sustain a business manufacturing custom flat panels in small volume specialty runs. As the number of suppliers willing to undertake this effort shrinks, avionics programs unable to utilize commercial-off-the-shelf (COTS) flat panels are placed in serious jeopardy. Rear projection technology offers a new paradigm, enabling compact systems to be tailored to specific platform needs while using a complement of COTS components. Projection displays enable improved performance, lower cost and shorter development cycles based on inter-program commonality and the wide use of commercial components. This paper reviews the promise and challenges of projection technology and provides an overview of Kaiser Electronics' efforts in developing advanced avionics displays using this approach.

Advanced Air Transportation Technologies Project, Final Document Collection

Science.gov (United States)

Mogford, Richard H.; Wold, Sheryl (Editor)

2008-01-01

This CD ROM contains a compilation of the final documents of the Advanced Air Transportation Technologies (AAIT) project, which was an eight-year (1996 to 2004), $400M project managed by the Airspace Systems Program office, which was part of the Aeronautics Research Mission Directorate at NASA Headquarters. AAIT focused on developing advanced automation tools and air traffic management concepts that would help improve the efficiency of the National Airspace System, while maintaining or enhancing safety. The documents contained in the CD are final reports on AAIT tasks that serve to document the project's accomplishments over its eight-year term. Documents include information on: Advanced Air Transportation Technologies, Autonomous Operations Planner, Collaborative Arrival Planner, Distributed Air/Ground Traffic Management Concept Elements 5, 6, & 11, Direct-To, Direct-To Technology Transfer, Expedite Departure Path, En Route Data Exchange, Final Approach Spacing Tool - (Active and Passive), Multi-Center Traffic Management Advisor, Multi Center Traffic Management Advisor Technology Transfer, Surface Movement Advisor, Surface Management System, Surface Management System Technology Transfer and Traffic Flow Management Research & Development.

Ceramic Technology for Advanced Heat Engines Project

Energy Technology Data Exchange (ETDEWEB)

1989-08-01

The Ceramic Technology for Advanced Heat Engines Project was developed by the Department of Energy's Office of Transportation Systems (OTS) in Conservation and Renewable Energy. This project, part of the OTS's Advanced Materials Development Program, was developed to meet the ceramic technology requirements of the OTS's automotive technology programs. Significant accomplishments in fabricating ceramic components for the Department of Energy (DOE), National Aeronautics and Space Administration (NASA), and Department of Defense (DoD) advanced heat engine programs have provided evidence that the operation of ceramic parts in high-temperature engine environments is feasible. However, these programs have also demonstrated that additional research is needed in materials and processing development, design methodology, and data base and life prediction before industry will have a sufficient technology base from which to produce reliable cost-effective ceramic engine components commercially.

Evaluation of Representative Smart Grid Investment Project Technologies: Demand Response

Energy Technology Data Exchange (ETDEWEB)

Fuller, Jason C.; Prakash Kumar, Nirupama; Bonebrake, Christopher A.

2012-02-14

This document is one of a series of reports estimating the benefits of deploying technologies similar to those implemented on the Smart Grid Investment Grant (SGIG) projects. Four technical reports cover the various types of technologies deployed in the SGIG projects, distribution automation, demand response, energy storage, and renewables integration. A fifth report in the series examines the benefits of deploying these technologies on a national level. This technical report examines the impacts of a limited number of demand response technologies and implementations deployed in the SGIG projects.

Disruption of Information Technology Projects: The Reactive Decoupling of Project Management Methodologies

Science.gov (United States)

Schmitz, Kurt W.

2013-01-01

Information Technology projects have migrated toward two dominant Project Management (PM) methodologies. Plan-driven practices provide organizational control through highly structured plans, schedules, and specifications that facilitate oversight by hierarchical bureaucracies. In contrast, agile practices emphasize empowered teams using flexible…

Application of Technology in Project-Based Distance Learning

Directory of Open Access Journals (Sweden)

Ali Mehrabian

2008-06-01

Full Text Available Present technology and the accessibility of internet have made distance learning easier, more efficient, and more convenient for students. This technology allows instructors and students to communicate asynchronously, at times and locations of their own choosing, by exchanging printed or electronic information. The use of project-based approach is being recognized in the literature as a potential component of courses in the faculties of engineering, science, and technology. Instructors may have to restructure their course differently to accommodate and facilitate the effectiveness of distance learning. A project-based engineering course, traditionally taught in a classroom settings using live mode at the College of Engineering and Computer Sciences at the University of Central Florida (UCF has been transformed to a distance course taught using distance modes. In this case, pedagogical transitions and adjustments are required, in particular for obtaining an optimal balance between the course material and the project work. Project collaboration in groups requires communication, which is possible with extensive utilization of new information and communication technology, such as virtual meetings. This paper discusses the course transition from live to distance modes and touches on some issues as they relate to the effectiveness of this methodology and the lessons learned from its application within different context. More specifically, this discussion includes the benefit of implementing project-based work in the domain of the distance learning courses.

Technology trajectories and the selection of optimal R and D project sequences

NARCIS (Netherlands)

van Bommel, Ties; Mahieu, R.J.; Nijssen, E.J.

2014-01-01

Given a set of R&D projects drawing on the same underlying technology, a technology trajectory refers to the order in which projects are executed. Due to their technological interdependence, the successful execution of one project can increase a firm's technological capability, and help to

Technology Foresight For Youth: A Project For Science and Technology Education in Sweden

Science.gov (United States)

Kendal, Anne Louise

"Technology Foresight for Youth" is a project run by two science museums, two science centres and "Technology Foresight (Sweden)" an organization in which both business and scientists are represented. The project is designed to strengthen young people's interest in ongoing technological work, research and education. It should give them confidence in their own ability both to understand today's techniques including its influence on people's daily lives, and to influence future developments. One part of the project is aimed at school teachers, teacher cooperation groups and students in the age group 12 to 18 years. A second part encourages dialog and meetings by arranging debates, seminars, theatre, science demonstrations in cooperation with business representatives and scientists. A third important part of the project is a special exhibition to be shown at the four cooperating institutions: "To be where I am not - young people's dreams about the future". The exhibition is meant to be sensual, interactive and partly virtual. It will change and grow with time as young people contribute with their thoughts, visions and challenges. Young people in different parts of the country will be able to interact electronically with each other and with the virtual part of the exhibition. The main aim of the project is to develop new interactive pedagogic methods for science and technology based on young people's own visions about the future.

Human factors and technology environment in multinational project: problems and solutions

International Nuclear Information System (INIS)

Jardi Besa, X.; Munoz Cervantes, A.

2012-01-01

At the onset of nuclear projects in Spain, there was an import of nuclear technology. In a second phase, there was a transfer of technology. Subsequently, there was an adaptation of the technology. In this evolution, comparable to that of other countries, were involved several countries, overcoming the difficulties of human factors involved. The current nuclear projects multinationals have a new difficulty: the different industrial technological environments. This paper will address the organizational challenges of multinational engineering projects, in the type of project and the human factors of the participating companies.

Two-Stage Translational Control of Dentate Gyrus LTP Consolidation Is Mediated by Sustained BDNF-TrkB Signaling to MNK

Directory of Open Access Journals (Sweden)

Debabrata Panja

2014-11-01

Full Text Available BDNF signaling contributes to protein-synthesis-dependent synaptic plasticity, but the dynamics of TrkB signaling and mechanisms of translation have not been defined. Here, we show that long-term potentiation (LTP consolidation in the dentate gyrus of live rodents requires sustained (hours BDNF-TrkB signaling. Surprisingly, this sustained activation maintains an otherwise labile signaling pathway from TrkB to MAP-kinase-interacting kinase (MNK. MNK activity promotes eIF4F translation initiation complex formation and protein synthesis in mechanistically distinct early and late stages. In early-stage translation, MNK triggers release of the CYFIP1/FMRP repressor complex from the 5′-mRNA cap. In late-stage translation, MNK regulates the canonical translational repressor 4E-BP2 in a synapse-compartment-specific manner. This late stage is coupled to MNK-dependent enhanced dendritic mRNA translation. We conclude that LTP consolidation in the dentate gyrus is mediated by sustained BDNF signaling to MNK and MNK-dependent regulation of translation in two functionally and mechanistically distinct stages.

Projection display industry market and technology trends

Science.gov (United States)

Castellano, Joseph A.; Mentley, David E.

1995-04-01

The projection display industry is diverse, embracing a variety of technologies and applications. In recent years, there has been a high level of interest in projection displays, particularly those using LCD panels or light valves because of the difficulty in making large screen, direct view displays. Many developers feel that projection displays will be the wave of the future for large screen HDTV (high-definition television), penetrating the huge existing market for direct view CRT-based televisions. Projection displays can have the images projected onto a screen either from the rear or the front; the main characteristic is their ability to be viewed by more than one person. In addition to large screen home television receivers, there are numerous other uses for projection displays including conference room presentations, video conferences, closed circuit programming, computer-aided design, and military command/control. For any given application, the user can usually choose from several alternative technologies. These include CRT front or rear projectors, LCD front or rear projectors, LCD overhead projector plate monitors, various liquid or solid-state light valve projectors, or laser-addressed systems. The overall worldwide market for projection information displays of all types and for all applications, including home television, will top DOL4.6 billion in 1995 and DOL6.45 billion in 2001.

Technology projects for characterization--monitoring of volatile organic compounds (VOCs)

Energy Technology Data Exchange (ETDEWEB)

Junk, G.A.; Haas, W.J. Jr.

1992-07-01

One hundred thirty technology project titles related to the characterization of volatile organic compounds (VOCs) at an arid site are listed alphabetically by first contact person in a master compilation that includes phone numbers, addresses, keywords, and short descriptions. Separate tables are presented for 62 field-demonstrated, 36 laboratory-demonstrated, and 35 developing technology projects. The technology projects in each of these three categories are also prioritized in separate summary tables. Additional tables are presented for a number of other categorizations of the technology projects: In Situ; Fiberoptic; Mass Spectrometer; Optical Spectroscopy; Raman or SERS; Ion Mobility or Acoustic; Associated; and Commercial. Four lists of contact person names are provided so details concerning the projects that deal with sampling, and VOCs in gases, waters, and soils (sediments) can be obtained. Finally, seven wide-ranging conclusions based on observations and experiences during this work are presented.

Technology projects for characterization--monitoring of volatile organic compounds (VOCs)

International Nuclear Information System (INIS)

Junk, G.A.; Haas, W.J. Jr.

1992-07-01

One hundred thirty technology project titles related to the characterization of volatile organic compounds (VOCs) at an arid site are listed alphabetically by first contact person in a master compilation that includes phone numbers, addresses, keywords, and short descriptions. Separate tables are presented for 62 field-demonstrated, 36 laboratory-demonstrated, and 35 developing technology projects. The technology projects in each of these three categories are also prioritized in separate summary tables. Additional tables are presented for a number of other categorizations of the technology projects: In Situ; Fiberoptic; Mass Spectrometer; Optical Spectroscopy; Raman or SERS; Ion Mobility or Acoustic; Associated; and Commercial. Four lists of contact person names are provided so details concerning the projects that deal with sampling, and VOCs in gases, waters, and soils (sediments) can be obtained. Finally, seven wide-ranging conclusions based on observations and experiences during this work are presented

Project Mechanisms and Technology Diffusion in Climate Policy - Kyoto project mechanisms and technology diffusion

International Nuclear Information System (INIS)

Glachant, M.; Meniere, Y.

2010-01-01

The paper deals with the diffusion of GHG mitigation technologies in developing countries. We develop a model where an abatement technology is progressively adopted by firms and we use it to compare the Clean Development Mechanism (CDM) with a standard Cap and Trade scheme (C and T). In the presence of learning spillovers, we show that the CDM yields a higher social welfare than C and T if the first adopter receives CDM credits whereas the followers do not. This result lends support to the policy proposal of relaxing the CDM additionality constraint for projects which generate significant learning externalities. (authors)

Ceramic Technology For Advanced Heat Engines Project

Energy Technology Data Exchange (ETDEWEB)

1990-12-01

Significant accomplishments in fabricating ceramic components for the Department of Energy (DOE), National Aeronautics and Space Administration (NASA), and Department of Defense (DoD) advanced heat engine programs have provided evidence that the operation of ceramic parts in high-temperature engine environments is feasible. However, these programs have also demonstrated that additional research is needed in materials and processing development, design methodology, and data base and life prediction before industry will have a sufficient technology base from which to produce reliable cost-effective ceramic engine components commercially. The objective of the project is to develop the industrial technology base required for reliable ceramics for application in advanced automotive heat engines. The project approach includes determining the mechanisms controlling reliability, improving processes for fabricating existing ceramics, developing new materials with increased reliability, and testing these materials in simulated engine environments to confirm reliability. Although this is a generic materials project, the focus is on the structural ceramics for advanced gas turbine and diesel engines, ceramic bearings and attachments, and ceramic coatings for thermal barrier and wear applications in these engines. This advanced materials technology is being developed in parallel and close coordination with the ongoing DOE and industry proof of concept engine development programs. To facilitate the rapid transfer of this technology to U.S. industry, the major portion of the work is being done in the ceramic industry, with technological support from government laboratories, other industrial laboratories, and universities. Abstracts prepared for appropriate papers.

Biologically inspired technologies in NASA's morphing project

Science.gov (United States)

McGowan, Anna-Maria R.; Cox, David E.; Lazos, Barry S.; Waszak, Martin R.; Raney, David L.; Siochi, Emilie J.; Pao, S. Paul

2003-07-01

For centuries, biology has provided fertile ground for hypothesis, discovery, and inspiration. Time-tested methods used in nature are being used as a basis for several research studies conducted at the NASA Langley Research Center as a part of Morphing Project, which develops and assesses breakthrough vehicle technologies. These studies range from low drag airfoil design guided by marine and avian morphologies to soaring techniques inspired by birds and the study of small flexible wing vehicles. Biology often suggests unconventional yet effective approaches such as non-planar wings, dynamic soaring, exploiting aeroelastic effects, collaborative control, flapping, and fibrous active materials. These approaches and other novel technologies for future flight vehicles are being studied in NASA's Morphing Project. This paper will discuss recent findings in the aeronautics-based, biologically-inspired research in the project.

Ischemic long-term-potentiation (iLTP: perspectives to set the threshold of neural plasticity toward therapy

Directory of Open Access Journals (Sweden)

Maximilian Lenz

2015-01-01

Full Text Available The precise role of neural plasticity under pathological conditions remains not well understood. It appears to be well accepted, however, that changes in the ability of neurons to express plasticity accompany neurological diseases. Here, we discuss recent experimental evidence, which suggests that synaptic plasticity induced by a pathological stimulus, i.e., ischemic long-term-potentiation (iLTP of excitatory synapses, could play an important role for post-stroke recovery by influencing the post-lesional reorganization of surviving neuronal networks.

Technology Cooperation Agreement Pilot Project (TCAPP)

Energy Technology Data Exchange (ETDEWEB)

Keegan, P.; Benioff, R.

1999-10-20

The Technology Cooperation Agreement Pilot Project (TCAPP) is helping developing countries design and implement actions to attract investment in clean energy technologies that will meet their economic development goals, while mitigating greenhouse gas emissions. TCAPP was launched by three US government agencies -- the US Agency for International Development (USAID), the US Environmental Protection Agency (USEPA), and the US Department of Energy (USDOE) -- in August 1997 to establish a model for climate change technology cooperation with developing and transition countries. This report describes the TCAPP approach and the significant progress made by the participating countries.

Ceramic Technology Project. Semiannual progress report for April 1993 through September 1993

Energy Technology Data Exchange (ETDEWEB)

1994-04-01

The Ceramic Technology Project was originally developed by the Department of Energy`s Office of Transportation Systems (OTS) in Conservation and Renewable Energy. This project, part of the OTS`s Materials Development Program, was developed to meet the ceramic technology requirements of the OTS`s automotive technology programs. During the course of the Ceramic Technology Project, remarkable progress has been made in the development of reliable structural ceramics. However, further work is needed to reduce the cost of ceramics to facilitate their commercial introduction, especially in the highly cost-sensitive automotive market. The work described in this report is organized according to the following WBS project elements: Project Management and Coordination; Materials and Processing; Materials Design Methodology; Data Base and Life Prediction; and Technology Transfer. This report includes contributions from all currently active project participants. Separate abstracts were prepared for the 47 projects reported here.

Long-term fluoxetine treatment induces input-specific LTP and LTD impairment and structural plasticity in the CA1 hippocampal subfield.

Directory of Open Access Journals (Sweden)

Francisco J Rubio

2013-05-01

Full Text Available Antidepressant drugs are usually administered for long time for the treatment of major depressive disorder. However, they are also prescribed in several additional psychiatric conditions as well as during long term maintenance treatments. Antidepressants induce adaptive changes in several forebrain structures which include modifications at glutamatergic synapses. We recently found that repetitive administration of the selective serotonin reuptake inhibitor fluoxetine to naϊve adult male rats induced an increase of mature, mushroom-type dendritic spines in several forebrain regions. This was associated with an increase of GluA2-containing α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors (AMPA-Rs in telencephalic postsynaptic densities. To unravel the functional significance of such a synaptic re-arrangement, we focused on glutamate neurotransmission in the hippocampus. We evaluated the effect of four weeks of treatment with 0.7 mg/kg of fluoxetine on long-term potentiation (LTP and long-term depression (LTD in the Schaffer collateral-CA1 synapses and the perforant path-CA1 synapses. Recordings in hippocampal slices revealed profound deficits in LTP and LTD at Schaffer collateral-CA1 synapses associated to increased spine density and enhanced presence of mushroom-type spines, as revealed by Golgi staining. However, the same treatment had neither an effect on spine morphology, nor on LTP and LTD at perforant path-CA1 synapses. Cobalt staining experiments revealed decreased AMPA-R Ca2+ permeability in the stratum radiatum together with increased GluA2-containing, Ca2+-impermeable AMPA-Rs. Therefore, 4 weeks of fluoxetine treatment promoted structural and functional adaptations in CA1 neurons in a pathway-specific manner that were selectively associated with impairment of activity-dependent plasticity at Schaffer collateral-CA1 synapses.

Technology integration project: Environmental Restoration Technologies Department Sandia National Laboratories

International Nuclear Information System (INIS)

Williams, C.V.; Burford, T.D.

1996-08-01

Sandia National Laboratories Environmental Restoration Technologies Department is developing environmental restoration technologies through funding form the US Department of Energy's (DOE's) Office of Science and Technology. Initially, this technology development has been through the Mixed Waste Landfill Integrated Demonstration (MWLID). It is currently being developed through the Contaminant Plume containment and Remediation Focus Area, the Landfill Stabilization Focus Area, and the Characterization, Monitoring, and Sensor Cross-Cutting Program. This Technology Integration Project (TIP) was responsible for transferring MWLID-developed technologies for routine use by environmental restoration groups throughout the DOE complex and commercializing these technologies to the private sector. The MWLID's technology transfer/commercialization successes were achieved by involving private industry in development, demonstration, and technology transfer/commercialization activities; gathering and disseminating information about MWLID activities and technologies; and promoting stakeholder and regulatory involvement. From FY91 through FY95, 30 Technical Task Plans (TTPs) were funded. From these TTPs, the MWLID can claim 15 technology transfer/commercialization successes. Another seven technology transfer/commercialization successes are expected. With the changeover to the focus areas, the TIP continued the technology transfer/commercialization efforts begun under the MWLID

Technology integration project: Environmental Restoration Technologies Department Sandia National Laboratories

Energy Technology Data Exchange (ETDEWEB)

Williams, C.V.; Burford, T.D. [Sandia National Labs., Albuquerque, NM (United States). Environmental Restoration Technologies; Allen, C.A. [Tech Reps, Inc., Albuquerque, NM (United States)

1996-08-01

Sandia National Laboratories Environmental Restoration Technologies Department is developing environmental restoration technologies through funding form the US Department of Energy`s (DOE`s) Office of Science and Technology. Initially, this technology development has been through the Mixed Waste Landfill Integrated Demonstration (MWLID). It is currently being developed through the Contaminant Plume containment and Remediation Focus Area, the Landfill Stabilization Focus Area, and the Characterization, Monitoring, and Sensor Cross-Cutting Program. This Technology Integration Project (TIP) was responsible for transferring MWLID-developed technologies for routine use by environmental restoration groups throughout the DOE complex and commercializing these technologies to the private sector. The MWLID`s technology transfer/commercialization successes were achieved by involving private industry in development, demonstration, and technology transfer/commercialization activities; gathering and disseminating information about MWLID activities and technologies; and promoting stakeholder and regulatory involvement. From FY91 through FY95, 30 Technical Task Plans (TTPs) were funded. From these TTPs, the MWLID can claim 15 technology transfer/commercialization successes. Another seven technology transfer/commercialization successes are expected. With the changeover to the focus areas, the TIP continued the technology transfer/commercialization efforts begun under the MWLID.

Beta-Adrenergic Receptor Activation during Distinct Patterns of Stimulation Critically Modulates the PKA-Dependence of LTP in the Mouse Hippocampus

Science.gov (United States)

Gelinas, Jennifer N.; Tenorio, Gustavo; Lemon, Neal; Abel, Ted; Nguyen, Peter V.

2008-01-01

Activation of Beta-adrenergic receptors (Beta-ARs) enhances hippocampal memory consolidation and long-term potentiation (LTP), a likely mechanism for memory storage. One signaling pathway linked to Beta-AR activation is the cAMP-PKA pathway. PKA is critical for the consolidation of hippocampal long-term memory and for the expression of some forms…

Accelerators for the advanced radiation technology project

International Nuclear Information System (INIS)

Maruyama, Michio

1990-01-01

Ion beam irradiation facilities are now under construction for the advanced radiation technology (ART) project in Takasaki Radiation Chemistry Research Establishment of (Japan Atomic Energy Research Institute) JAERI. The project is intended to make an effective use of ion beams, especially ion beams, in the research field of radiation application technology. The TIARA (Takasaki Ion Accelerators for Advanced Radiation Application) facilities include four ion accelerators to produce almost all kinds of energetic ions in the periodic table. The facilities are also provided with several advanced irradiation means and act as very powerful accelerator complex for material development. Specifically, this report presents an outline of the ART project, features of TIARA as accelerator facilities dedicated to material development, the AVF cyclotron under construction (Sumitomo Heavy Industries, Ltd., Model 930), tandem accelerator, microbeam, and experimental instruments used. (N.K.)

Cyrogenic Life Support Technology Development Project

Science.gov (United States)

Bush, David R.

2015-01-01

KSC has used cryogenic life support (liquid air based) technology successfully for many years to support spaceflight operations. This technology has many benefits unique to cryogenics when compared to traditional compressed gas systems: passive cooling, lighter, longer duration, and lower operating pressure. However, there are also several limiting factors that have prevented the technology from being commercialized. The National Institute of Occupational Safety and Health, Office of Mine Safety and Health Research (NIOSH-OMSHR) has partnered with NASA to develop a complete liquid air based life support solution for emergency mine escape and rescue. The project will develop and demonstrate various prototype devices and incorporate new technological innovations that have to date prevented commercialization.

Proposed Project Selection Method for Human Support Research and Technology Development (HSR&TD)

Science.gov (United States)

Jones, Harry

2005-01-01

The purpose of HSR&TD is to deliver human support technologies to the Exploration Systems Mission Directorate (ESMD) that will be selected for future missions. This requires identifying promising candidate technologies and advancing them in technology readiness until they are acceptable. HSR&TD must select an may of technology development projects, guide them, and either terminate or continue them, so as to maximize the resulting number of usable advanced human support technologies. This paper proposes an effective project scoring methodology to support managing the HSR&TD project portfolio. Researchers strongly disagree as to what are the best technology project selection methods, or even if there are any proven ones. Technology development is risky and outstanding achievements are rare and unpredictable. There is no simple formula for success. Organizations that are satisfied with their project selection approach typically use a mix of financial, strategic, and scoring methods in an open, established, explicit, formal process. This approach helps to build consensus and develop management insight. It encourages better project proposals by clarifying the desired project attributes. We propose a project scoring technique based on a method previously used in a federal laboratory and supported by recent research. Projects are ranked by their perceived relevance, risk, and return - a new 3 R's. Relevance is the degree to which the project objective supports the HSR&TD goal of developing usable advanced human support technologies. Risk is the estimated probability that the project will achieve its specific objective. Return is the reduction in mission life cycle cost obtained if the project is successful. If the project objective technology performs a new function with no current cost, its return is the estimated cash value of performing the new function. The proposed project selection scoring method includes definitions of the criteria, a project evaluation

A Survey of Technologies Supporting Virtual Project Based Learning

DEFF Research Database (Denmark)

Dirckinck-Holmfeld, Lone

2002-01-01

This paper describes a survey of technologies and to what extent they support virtual project based learning. The paper argues that a survey of learning technologies should be related to concrete learning tasks and processes. Problem oriented project pedagogy (POPP) is discussed, and a framework...... for evaluation is proposed where negotiation of meaning, coordination and resource management are identified as the key concepts in virtual project based learning. Three e-learning systems are selected for the survey, Virtual-U, Lotus Learningspace and Lotus Quickplace, as each system offers different strategies...... for e-learning. The paper concludes that virtual project based learning may benefit from facilities of all these systems....

Technology Investments in the NASA Entry Systems Modeling Project

Science.gov (United States)

Barnhardt, Michael; Wright, Michael; Hughes, Monica

2017-01-01

The Entry Systems Modeling (ESM) technology development project, initiated in 2012 under NASAs Game Changing Development (GCD) Program, is engaged in maturation of fundamental research developing aerosciences, materials, and integrated systems products for entry, descent, and landing(EDL)technologies [1]. To date, the ESM project has published over 200 papers in these areas, comprising the bulk of NASAs research program for EDL modeling. This presentation will provide an overview of the projects successes and challenges, and an assessment of future investments in EDL modeling and simulation relevant to NASAs mission

Data analysis for the LISA Technology Package

Energy Technology Data Exchange (ETDEWEB)

Hewitson, M; Danzmann, K; Diepholz, I; GarcIa, A [Albert-Einstein-Institut, Max-Planck-Institut fuer Gravitationsphysik und Universitaet Hannover, 30167 Hannover (Germany); Armano, M; Fauste, J [European Space Agency, ESAC, Villanueva de la Canada, 28692 Madrid (Spain); Benedetti, M [Dipartimento di Ingegneria dei Materiali e Tecnologie Industriali, Universita di Trento and INFN, Gruppo Collegato di Trento, Mesiano, Trento (Italy); Bogenstahl, J [Department of Physics and Astronomy, University of Glasgow, Glasgow (United Kingdom); Bortoluzzi, D; Bosetti, P; Cristofolini, I [Dipartimento di Ingegneria Meccanica e Strutturale, Universita di Trento and INFN, Gruppo Collegato di Trento, Mesiano, Trento (Italy); Brandt, N [Astrium GmbH, 88039 Friedrichshafen (Germany); Cavalleri, A; Ciani, G; Dolesi, R; Ferraioli, L [Dipartimento di Fisica, Universita di Trento and INFN, Gruppo Collegato di Trento, 38050 Povo, Trento (Italy); Cruise, M [Department of Physics and Astronomy, University of Birmingham, Birmingham (United Kingdom); Fertin, D; GarcIa, C [European Space Agency, ESTEC, 2200 AG Noordwijk (Netherlands); Fichter, W, E-mail: martin.hewitson@aei.mpg.d [Institut fuer Flugmechanik und Flugregelung, 70569 Stuttgart (Germany)

2009-05-07

The LISA Technology Package (LTP) on board the LISA Pathfinder mission aims to demonstrate some key concepts for LISA which cannot be tested on ground. The mission consists of a series of preplanned experimental runs. The data analysis for each experiment must be designed in advance of the mission. During the mission, the analysis must be carried out promptly so that the results can be fed forward into subsequent experiments. As such a robust and flexible data analysis environment needs to be put in place. Since this software is used during mission operations and effects the mission timeline, it must be very robust and tested to a high degree. This paper presents the requirements, design and implementation of the data analysis environment (LTPDA) that will be used for analysing the data from LTP. The use of the analysis software to perform mock data challenges (MDC) is also discussed, and some highlights from the first MDC are presented.

Data analysis for the LISA Technology Package

International Nuclear Information System (INIS)

Hewitson, M; Danzmann, K; Diepholz, I; GarcIa, A; Armano, M; Fauste, J; Benedetti, M; Bogenstahl, J; Bortoluzzi, D; Bosetti, P; Cristofolini, I; Brandt, N; Cavalleri, A; Ciani, G; Dolesi, R; Ferraioli, L; Cruise, M; Fertin, D; GarcIa, C; Fichter, W

2009-01-01

The LISA Technology Package (LTP) on board the LISA Pathfinder mission aims to demonstrate some key concepts for LISA which cannot be tested on ground. The mission consists of a series of preplanned experimental runs. The data analysis for each experiment must be designed in advance of the mission. During the mission, the analysis must be carried out promptly so that the results can be fed forward into subsequent experiments. As such a robust and flexible data analysis environment needs to be put in place. Since this software is used during mission operations and effects the mission timeline, it must be very robust and tested to a high degree. This paper presents the requirements, design and implementation of the data analysis environment (LTPDA) that will be used for analysing the data from LTP. The use of the analysis software to perform mock data challenges (MDC) is also discussed, and some highlights from the first MDC are presented.

Supporting Project Work with Information Technology

DEFF Research Database (Denmark)

Heilesen, Simon

2015-01-01

University problem-oriented project work is based. However, in implementing and integrating the new technologies in academic practices, a number of challenges have had to be addressed. This chapter discusses four of these challenges. The first is to provide a physical and virtual framework for learning......Like so many other institutions, Roskilde University has had to adapt to the new realities brought about by the rapid developments in information and communication technology (ICT). On the whole, ICT tools have proven to be helpful in supporting and developing the work forms on which Roskilde...... activities. The second is to direct student use of ICT in terms of making systems available and teaching academic computing. The third challenge is to supervise and conduct project work online and in blended learning environments. Finally, one must find a way to exploit the potentials of ICT in problem...

Supporting Project Work with Information Technology

DEFF Research Database (Denmark)

Heilesen, Simon

2015-01-01

University problem-oriented project work is based. However, in implementing and integrating the new technologies in academic practices, a number of challenges have had to be addressed. This chapter discusses four of these challenges. The first is to provide a physical and virtual framework for learning...... activities. The second is to direct student use of ICT in terms of making systems available and teaching academic computing. The third challenge is to supervise and conduct project work online and in blended learning environments. Finally, one must find a way to exploit the potentials of ICT in problem......Like so many other institutions, Roskilde University has had to adapt to the new realities brought about by the rapid developments in information and communication technology (ICT). On the whole, ICT tools have proven to be helpful in supporting and developing the work forms on which Roskilde...

The process of selecting technology development projects: a practical framework

NARCIS (Netherlands)

Herps, Joost M.J.; van Mal, Herman H.; Halman, Johannes I.M.; Martens, Jack H.M.; Borsboom, Ron H.M.

2003-01-01

In this article a practical framework is proposed, that can be used to organise the activities related to the selection-process of technology development projects. The framework is based upon recent literature and application at DAF Trucks Company. A technology development project has a long way to

The process of selecting technology development projects : a practical framework

NARCIS (Netherlands)

Herps, J.M.J.; Mal, van H.H.; Halman, J.I.M.; Martens, J.H.M.; Borsboom, R.H.M.

2003-01-01

In this article a practical framework is proposed, that can be used to organise the activities related to the selection-process of technology development projects. The framework is based upon recent literature and application at DAF Trucks Company. A technology development project has a long way to

SUCCESS CONCEPT ANALYSIS APPLIED TO THE INFORMATION TECHNOLOGY PROJECT MANAGEMENT

Directory of Open Access Journals (Sweden)

Cassio C. Montenegro Duarte

2012-05-01

Full Text Available This study evaluates the concept of success in project management that is applicable to the IT universe, from the classical theory associated with the techniques of project management. Therefore, it applies the theoretical analysis associated to the context of information technology in enterprises as well as the classic literature of traditional project management, focusing on its application in business information technology. From the literature developed in the first part of the study, four propositions were prepared for study which formed the basis for the development of the field research with three large companies that develop projects of Information Technology. The methodology used in the study predicted the development of the multiple case study. Empirical evidence suggests that the concept of success found in the classical literature in project management adjusts to the environment management of IT projects. Showed that it is possible to create the model of standard IT projects in order to replicate it in future derivatives projects, which depends on the learning acquired at the end of a long and continuous process and sponsorship of senior management, which ultimately results in its merger into the company culture.

SELENIUM TREATMENT/REMOVAL ALTERNATIVES DEMONSTRATION PROJECT - MINE WASTE TECHNOLOGY PROGRAM ACTIVITY III, PROJECT 20

Science.gov (United States)

This document is the final report for EPA's Mine WAste Technology Program (MWTP) Activity III, Project 20--Selenium Treatment/Removal Alternatives Demonstration project. Selenium contamination originates from many sources including mining operations, mineral processing, abandoned...

Photovoltaic concentrator technology development project. Sixth project integration meeting

Energy Technology Data Exchange (ETDEWEB)

None

1980-10-01

Thirty-three abstracts and short papers are presented which describe the current status of research, development, and demonstration of concentrator solar cell technology. Solar concentrators discussed include the parabolic trough, linear focus Fresnel lens, point focus Fresnel lens, and the parabolic dish. Solar cells studied include silicon, GaAs, and AlGaAs. Research on multiple junction cells, combined photovoltaic/thermal collectors, back contact solar cells, and beam splitter modules is described. Concentrator solar cell demonstration programs are reported. Contractor status summaries are given for 33 US DOE concentrator solar cell contracts; a description of the project, project status, and key results to date is included. (WHK)

Characterization of a new antifungal non-specific lipid transfer protein (nsLTP) from sugar beet leaves

DEFF Research Database (Denmark)

Kristensen, A K; Brunstedt, J; Madsen, M T

2000-01-01

A novel protein (IWF5) comprising 92 amino acids has been purified from the intercellular washing fluid of sugar beet leaves using cation exchange chromatography and reversed phase high performance liquid chromatography. Based on amino acid sequence homology, including the presence of eight...... cysteines at conserved positions, the protein can be classified as a member of the plant family of non-specific lipid transfer proteins (nsLTPs). The protein is 47% identical to IWF1, an antifungal nsLTP previously isolated from leaves of sugar beet. A potential site for N-linked glycosylation present...

Correlational Study of Project Managers' Competence Experience, Education, and Technology Experience on Project

Science.gov (United States)

Hosford, Bryan

2017-01-01

Organizations continue to rely on information technology (IT) as a foundational element, yet poor IT project success continues to impact growth and innovation. Research into IT project success is widespread yet has focused on high-level project management attributes, not specific IT solutions. A review of the research literature revealed that the…

Technology Transfer and Outreach for SNL/Rochester ALPHA Project.

Energy Technology Data Exchange (ETDEWEB)

Sinars, Daniel [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2016-01-01

This report describes the next stage goals and resource needs for the joint Sandia and University of Rochester ARPA-E project. A key portion of this project is Technology Transfer and Outreach, with the goal being to help ensure that this project develops a credible method or tool that the magneto-inertial fusion (MIF) research community can use to broaden the advocacy base, to pursue a viable path to commercial fusion energy, and to develop other commercial opportunities for the associated technology. This report describes an analysis of next stage goals and resource needs as requested by Milestone 5.1.1.

Ceramic Technology Project. Semiannual progress report, April 1991--September 1991

Energy Technology Data Exchange (ETDEWEB)

1992-03-01

The Ceramic Technology Project was developed by the USDOE Office of Transportation Systems (OTS) in Conservation and Renewable Energy. This project, part of the OTS`s Materials Development Program, was developed to meet the ceramic technology requirements of the OTS`s automotive technology programs. Significant accomplishments in fabricating ceramic components for the USDOE and NASA advanced heat engine programs have provided evidence that the operation of ceramic parts in high-temperature engine environments is feasible. These programs have also demonstrated that additional research is needed in materials and processing development, design methodology, and data base and life prediction before industry will have a sufficient technology base from which to produce reliable cost-effective ceramic engine components commercially. A five-year project plan was developed with extensive input from private industry. In July 1990 the original plan was updated through the estimated completion of development in 1993. The objective is to develop the industrial technology base required for reliable ceramics for application in advanced automotive heat engines. The project approach includes determining the mechanisms controlling reliability, improving processes for fabricating existing ceramics, developing new materials with increased reliability, and testing these materials in simulated engine environments to confirm reliability. Although this is a generic materials project, the focus is on the structural ceramics for advanced gas turbine and diesel engines, ceramic bearings and attachments, and ceramic coatings for thermal barrier and wear applications in these engines. To facilitate the rapid transfer of this technology to US industry, the major portion of the work is being done in the ceramic industry, with technological support from government laboratories, other industrial laboratories, and universities.

Evaluation of Representative Smart Grid Investment Grant Project Technologies: Thermal Energy Storage

Energy Technology Data Exchange (ETDEWEB)

Tuffner, Francis K.; Bonebrake, Christopher A.

2012-02-14

This document is one of a series of reports estimating the benefits of deploying technologies similar to those implemented on the Smart Grid Investment Grant (SGIG) projects. Four technical reports cover the various types of technologies deployed in the SGIG projects, distribution automation, demand response, energy storage, and renewables integration. A fifth report in the series examines the benefits of deploying these technologies on a national level. This technical report examines the impacts of energy storage technologies deployed in the SGIG projects.

Fixed Wing Project: Technologies for Advanced Air Transports

Science.gov (United States)

Del Rosario, Ruben; Koudelka, John M.; Wahls, Richard A.; Madavan, Nateri

2014-01-01

The NASA Fundamental Aeronautics Fixed Wing (FW) Project addresses the comprehensive challenge of enabling revolutionary energy efficiency improvements in subsonic transport aircraft combined with dramatic reductions in harmful emissions and perceived noise to facilitate sustained growth of the air transportation system. Advanced technologies and the development of unconventional aircraft systems offer the potential to achieve these improvements. Multidisciplinary advances are required in aerodynamic efficiency to reduce drag, structural efficiency to reduce aircraft empty weight, and propulsive and thermal efficiency to reduce thrust-specific energy consumption (TSEC) for overall system benefit. Additionally, advances are required to reduce perceived noise without adversely affecting drag, weight, or TSEC, and to reduce harmful emissions without adversely affecting energy efficiency or noise.The presentation will highlight the Fixed Wing project vision of revolutionary systems and technologies needed to achieve these challenging goals. Specifically, the primary focus of the FW Project is on the N+3 generation; that is, vehicles that are three generations beyond the current state of the art, requiring mature technology solutions in the 2025-30 timeframe.

Telecommunication Technologies for Smart Grid Projects with Focus on Smart Metering Applications

Directory of Open Access Journals (Sweden)

Nikoleta Andreadou

2016-05-01

Full Text Available This paper provides a study of the smart grid projects realised in Europe and presents their technological solutions with a focus on smart metering Low Voltage (LV applications. Special attention is given to the telecommunications technologies used. For this purpose, we present the telecommunication technologies chosen by several European utilities for the accomplishment of their smart meter national roll-outs. Further on, a study is performed based on the European Smart Grid Projects, highlighting their technological options. The range of the projects analysed covers the ones including smart metering implementation as well as those in which smart metering applications play a significant role in the overall project success. The survey reveals that various topics are directly or indirectly linked to smart metering applications, like smart home/building, energy management, grid monitoring and integration of Renewable Energy Sources (RES. Therefore, the technological options that lie behind such projects are pointed out. For reasons of completeness, we also present the main characteristics of the telecommunication technologies that are found to be used in practice for the LV grid.

National Security Technology Incubation Project Continuation Plan

Energy Technology Data Exchange (ETDEWEB)

None

2008-09-30

This document contains a project continuation plan for the National Security Technology Incubator (NSTI). The plan was developed as part of the National Security Preparedness Project (NSPP) funded by a Department of Energy (DOE)/National Nuclear Security Administration (NNSA) grant. This continuation plan describes the current status of NSTI (staffing and clients), long-term goals, strategies, and long-term financial solvency goals.The Arrowhead Center of New Mexico State University (NMSU) is the operator and manager of the NSTI. To realize the NSTI, Arrowhead Center must meet several performance objectives related to planning, development, execution, evaluation, and sustainability. This continuation plan is critical to the success of NSTI in its mission of incubating businesses with security technology products and services.

Leadership Styles: Perceptions in Information Technology Project Teams

Science.gov (United States)

Fune, Roy P.

2013-01-01

The purpose of this study was to uncover Information Technology (IT) Project Managers' and IT Professionals' perceptions of effective leadership styles as they apply to project success. There have been prior studies dealing with the differences in perceptions between IT Functional Manager's leadership self-perception versus staff perceptions of…

Evaluation of Representative Smart Grid Investment Grant Project Technologies: Distributed Generation

Energy Technology Data Exchange (ETDEWEB)

Singh, Ruchi; Vyakaranam, Bharat GNVSR

2012-02-14

This document is one of a series of reports estimating the benefits of deploying technologies similar to those implemented on the Smart Grid Investment Grant (SGIG) projects. Four technical reports cover the various types of technologies deployed in the SGIG projects, distribution automation, demand response, energy storage, and renewables integration. A fifth report in the series examines the benefits of deploying these technologies on a national level. This technical report examines the impacts of addition of renewable resources- solar and wind in the distribution system as deployed in the SGIG projects.

Project approach helps technology transfer

International Nuclear Information System (INIS)

Walcher, M.W.

1982-01-01

The placing of the contract by the National Power Corporation with Westinghouse for the Philippines nuclear power plant (PNPP-1) is described. Maximised use of Philippine contractors under Westinghouse supervision was provided for. Technology transfer is an important benefit of the contract arrangements, since National Power Corporation project management acquires considerable nuclear plant experience during plant construction through consultation with technical personnel. (U.K.)

Materials Development Program: Ceramic Technology Project bibliography, 1984--1992

Energy Technology Data Exchange (ETDEWEB)

1994-03-01

The Ceramic Technology [for Advanced Heat Engines] Project was begun in 1983 to meet the ceramic materials needs of the companion DOE automotive engine program, the Advanced Gas Turbine (AGT) project, and the Heavy Duty Transport (low-heat-rejection, heavy-duty diesel) project. Goal is to develop an industry technology base for reliable and cost effective ceramics for applications in advanced automotive gas turbine and diesel engines. Research areas were identified following extensive input from industry and academia. Majority of research is done by industry (60%); work is also done at colleges and universities, in-house, and at other national laboratories and government agencies. In the beginning, reliability of ceramic components was the key issue. The reliability issues have largely been met and, at the present time, cost is the driving issue, especially in light of the highly cost-sensitive automotive market. Emphasis of the program has now been shifted toward developing cost-effective ceramic components for high-performance engines in the near-term. This bibliography is a compilation of publications done in conjunction with the Ceramic Technology Project since its beginning. Citations were obtained from reports done by participants in the project. We have tried to limit citations to those published and easily located. The end date of 1992 was selected.

Characteristic of Extracellular Zn2+ Influx in the Middle-Aged Dentate Gyrus and Its Involvement in Attenuation of LTP.

Science.gov (United States)

Takeda, Atsushi; Koike, Yuta; Osaw, Misa; Tamano, Haruna

2018-03-01

An increased influx of extracellular Zn 2+ into neurons is a cause of cognitive decline. The influx of extracellular Zn 2+ into dentate granule cells was compared between young and middle-aged rats because of vulnerability of the dentate gyrus to aging. The influx of extracellular Zn 2+ into dentate granule cells was increased in middle-aged rats after injection of AMPA and high K + into the dentate gyrus, but not in young rats. Simultaneously, high K + -induced attenuation of LTP was observed in middle-aged rats, but not in young rats. The attenuation was rescued by co-injection of CaEDTA, an extracellular Zn 2+ chelator. Intracellular Zn 2+ in dentate granule cells was also increased in middle-aged slices with high K + , in which the increase in extracellular Zn 2+ was the same as young slices with high K + , suggesting that ability of extracellular Zn 2+ influx into dentate granule cells is greater in middle-aged rats. Furthermore, extracellular zinc concentration in the hippocampus was increased age-dependently. The present study suggests that the influx of extracellular Zn 2+ into dentate granule cells is more readily increased in middle-aged rats and that its increase is a cause of age-related attenuation of LTP in the dentate gyrus.

Boosting the LTP-like plasticity effect of intermittent theta-burst stimulation using gamma transcranial alternating current stimulation.

Science.gov (United States)

Guerra, Andrea; Suppa, Antonio; Bologna, Matteo; D'Onofrio, Valentina; Bianchini, Edoardo; Brown, Peter; Di Lazzaro, Vincenzo; Berardelli, Alfredo

2018-03-24

Transcranial Alternating Current Stimulation (tACS) consists in delivering electric current to the brain using an oscillatory pattern that may entrain the rhythmic activity of cortical neurons. When delivered at gamma frequency, tACS modulates motor performance and GABA-A-ergic interneuron activity. Since interneuronal discharges play a crucial role in brain plasticity phenomena, here we co-stimulated the primary motor cortex (M1) in healthy subjects by means of tACS during intermittent theta-burst stimulation (iTBS), a transcranial magnetic stimulation paradigm known to induce long-term potentiation (LTP)-like plasticity. We measured and compared motor evoked potentials before and after gamma, beta and sham tACS-iTBS. While we delivered gamma-tACS, we also measured short-interval intracortical inhibition (SICI) to detect any changes in GABA-A-ergic neurotransmission. Gamma, but not beta and sham tACS, significantly boosted and prolonged the iTBS-induced after-effects. Interestingly, the extent of the gamma tACS-iTBS after-effects correlated directly with SICI changes. Overall, our findings point to a link between gamma oscillations, interneuronal GABA-A-ergic activity and LTP-like plasticity in the human M1. Gamma tACS-iTBS co-stimulation might represent a new strategy to enhance and prolong responses to plasticity-inducing protocols, thereby lending itself to future applications in the neurorehabilitation setting. Copyright © 2018 Elsevier Inc. All rights reserved.

Project planning of Gen-IV sodium cooled fast reactor technology

Energy Technology Data Exchange (ETDEWEB)

Yoo, Jaewoon; Joo, H. K.; Cho, C. H.; Kim, Y. G.; Lee, D. U.; Jin, M. W.

2013-05-15

The project program will be established to shorten the design schedule by sharing the design man power and experimental facility, and by introducing the proven technology through international collaboration and the project plan including preliminary specific design, technology validation and fuel design validation plan will be more detail by reviewing the plan at the International Technical Review Meeting (ITRM). Periodic project progress review meeting will be held to find the technical issues and to resolve them. The results of the progress review meeting will be reflected into the final assessment of research project. The project progress review meeting will be held every quarter and external expert will also participate in the meeting. In parallel with the PGSFR development, innovative small modular SFR will be developed aiming to the international nuclear market. The system and component technologies of both system can be shared but innovative concept will be implemented into the design. Ultra long life core design concept and supercritical CO{sub 2} Brayton cycle will be considered as the innovative concept for enhancing the plant economy and safety.

Project planning of Gen-IV sodium cooled fast reactor technology

International Nuclear Information System (INIS)

Yoo, Jaewoon; Joo, H. K.; Cho, C. H.; Kim, Y. G.; Lee, D. U.; Jin, M. W.

2013-05-01

The project program will be established to shorten the design schedule by sharing the design man power and experimental facility, and by introducing the proven technology through international collaboration and the project plan including preliminary specific design, technology validation and fuel design validation plan will be more detail by reviewing the plan at the International Technical Review Meeting (ITRM). Periodic project progress review meeting will be held to find the technical issues and to resolve them. The results of the progress review meeting will be reflected into the final assessment of research project. The project progress review meeting will be held every quarter and external expert will also participate in the meeting. In parallel with the PGSFR development, innovative small modular SFR will be developed aiming to the international nuclear market. The system and component technologies of both system can be shared but innovative concept will be implemented into the design. Ultra long life core design concept and supercritical CO 2 Brayton cycle will be considered as the innovative concept for enhancing the plant economy and safety

GABAergic Synapses at the Axon Initial Segment of Basolateral Amygdala Projection Neurons Modulate Fear Extinction.

Science.gov (United States)

Saha, Rinki; Knapp, Stephanie; Chakraborty, Darpan; Horovitz, Omer; Albrecht, Anne; Kriebel, Martin; Kaphzan, Hanoch; Ehrlich, Ingrid; Volkmer, Hansjürgen; Richter-Levin, Gal

2017-01-01

Inhibitory synaptic transmission in the amygdala has a pivotal role in fear learning and its extinction. However, the local circuits formed by GABAergic inhibitory interneurons within the amygdala and their detailed function in shaping these behaviors are not well understood. Here we used lentiviral-mediated knockdown of the cell adhesion molecule neurofascin in the basolateral amygdala (BLA) to specifically remove inhibitory synapses at the axon initial segment (AIS) of BLA projection neurons. Quantitative analysis of GABAergic synapse markers and measurement of miniature inhibitory postsynaptic currents in BLA projection neurons after neurofascin knockdown ex vivo confirmed the loss of GABAergic input. We then studied the impact of this manipulation on anxiety-like behavior and auditory cued fear conditioning and its extinction as BLA related behavioral paradigms, as well as on long-term potentiation (LTP) in the ventral subiculum-BLA pathway in vivo. BLA knockdown of neurofascin impaired ventral subiculum-BLA-LTP. While this manipulation did not affect anxiety-like behavior and fear memory acquisition and consolidation, it specifically impaired extinction. Our findings indicate that modification of inhibitory synapses at the AIS of BLA projection neurons is sufficient to selectively impair extinction behavior. A better understanding of the role of distinct GABAergic synapses may provide novel and more specific targets for therapeutic interventions in extinction-based therapies.

Diagnostic framework and health check tool for engineering and technology projects

Directory of Open Access Journals (Sweden)

Simon P Philbin

2014-10-01

Full Text Available Purpose: Development of a practitioner oriented diagnostic framework and health check tool to support the robust assessment of engineering and technology projects.Design/methodology/approach: The research is based on a literature review that draws together insights on project assessment and critical success factors to establish an integrated systems view of projects. This is extended to allow a comprehensive diagnostic framework to be developed along with a high-level health check tool that can be readily deployed on projects. The utility of the diagnostic framework and health check tool are explored through three illustrative case studies, with two from Canada and one from the United Kingdom. Findings andOriginality/value: The performance of engineering and technology projects can be viewed through a systems perspective and being a function of six sub-systems that are: process, technology, resources, impact, knowledge and culture. The diagnostic framework that is developed through this research integrates these sub-systems to provide a comprehensive assessment methodology for projects, which is linked to existing best practice for project reviews, performance management and maturity models. The case studies provide managerial insights that are related to the diagnostic framework but crucially also position the approach in the context of industrial applications for construction engineering and technology management.Research limitations/implications: The case study approach includes two case studies from the construction and facilities development sector with the third case study from the research and technology sector. Further work is required to investigate the use of the diagnostic framework and health check tool in other sectors.Practical implications: The health check tool will be of practical benefit to new projects managers that require access to a robust and convenient project review methodology for assessing the status and health of a

Influences of Government Championship on the Technology Innovation Process at the Project-level

Science.gov (United States)

Yue, Xin

Government support is a popular instrument to foster technology innovation. It can take various forms such as financial aid, tax credits, and technological assistance. Along with the firm characteristics, strategic behavior of the project team, characteristics of the technology and the market, and the regulatory environment, government support influences firms' research and development (R&D) motivations, decision making process, and hence technology development performance. How government support influences the performance in different industries is an important policy and research question. There are many studies on the effectiveness and impacts of government support, mostly at program-level or industry-level. Government Championship is a form of government support distinct from direct financial or technological assistance. Championship includes expressing confidence in the innovation, encouraging others to support the innovation, and persisting under adversity. Championship has been studied as a critical inside factor for innovation success, particularly at project-level. Usually a champion emerged within the organization responsible for the innovation project. However, with the intention to encourage technology development, governments can also play a championship role. Government championship, besides government financial and technological assistance (hereafter "government F&T"), could be one major category of government support to facilitate high-technology innovation. However, there are few studies focusing on the effectiveness of government championship, and how it influences the innovation process. This thesis addresses this question through two studies on high-technology development projects. The first study has tested the effectiveness of government championship on the performance of 431 government sponsored technology innovation projects. Government championship and government F&T, as well as project team strategic behavior, are hypothesized to influence

Technological Innovation Projects: Proposal For an Integrative Model Between Project Management and Knowledge Management in a Customer-Supplier Perspective

Directory of Open Access Journals (Sweden)

Edval da Silva Tavares

2014-10-01

Full Text Available In face of strong competition, companies in Brazil have increased their financial investments in automation, offering new products and services and reducing operating costs. These companies are focusing their efforts on core competencies and, therefore, they often lack the internal expertise to implement new projects, especially those that bring technological innovation. For this reason, we use the processes of outsourcing or subcontracting to help implement such projects. The unit of analysis in this study is the project and the object of the study to analyze the process of knowledge transfer from a provider to a customer during the duration of the project, which involves new technologies. The main motivation of this work is to address the acquisition and retention of new knowledge related to projects designed for business customers. We have developed a study of three cases of multiple financial firms that buy new technologies and two suppliers of information technology. As a practical result, a management model of knowledge transfer and retention of knowledge in client companies is proposed and incorporated into project management.

Delivering construction projects using innovative building technologies

CSIR Research Space (South Africa)

Ampofo-Anti, Naalamkai

2017-07-01

Full Text Available . Figure 1: IBT delivery flowchart Proceedings 11th Built Environment Conference 6 th August – 8 th August 2017 Delivering construction projects using innovative building technologies Durban, South Africa 5. REFERENCES Ampofo-Anti, N...

Pilot Project Technology Business Case: Mobile Work Packages

Energy Technology Data Exchange (ETDEWEB)

Thomas, Ken [Idaho National Lab. (INL), Idaho Falls, ID (United States); Lawrie, Sean [ScottMadden, Inc., Raleigh, NC (United States); Niedermuller, Josef [ScottMadden, Inc., Raleigh, NC (United States)

2015-05-01

Performance advantages of the new pilot project technologies are widely acknowledged, but it has proven difficult for utilities to derive business cases for justifying investment in these new capabilities. Lack of a business case is often cited by utilities as a barrier to pursuing wide-scale application of digital technologies to nuclear plant work activities. The decision to move forward with funding usually hinges on demonstrating actual cost reductions that can be credited to budgets and thereby truly reduce O&M or capital costs. Technology enhancements, while enhancing work methods and making work more efficient, often fail to eliminate workload such that it changes overall staffing and material cost requirements. It is critical to demonstrate cost reductions or impacts on non-cost performance objectives in order for the business case to justify investment by nuclear operators. The Business Case Methodology (BCM) was developed in September of 2015 to frame the benefit side of II&C technologies to address the “benefit” side of the analysis—as opposed to the cost side—and how the organization evaluates discretionary projects (net present value (NPV), accounting effects of taxes, discount rates, etc.). The cost and analysis side is not particularly difficult for the organization and can usually be determined with a fair amount of precision (not withstanding implementation project cost overruns). It is in determining the “benefits” side of the analysis that utilities have more difficulty in technology projects and that is the focus of this methodology. The methodology is presented in the context of the entire process, but the tool provided is limited to determining the organizational benefits only. This report describes a the use of the BCM in building a business case for mobile work packages, which includes computer-based procedures and other automated elements of a work package. Key to those impacts will be identifying where the savings are �

78 FR 32637 - Science and Technology Reinvention Laboratory Personnel Management Demonstration Project...

Science.gov (United States)

2013-05-31

..., Science and Technology Reinvention Laboratory Personnel Management Demonstration Project, Department of... DEPARTMENT OF DEFENSE Office of the Secretary Science and Technology Reinvention Laboratory Personnel Management Demonstration Project, Department of the Army, Army Research, Development and...

Bringing Technology to Students’ Proximity: A Sociocultural Account of Technology-Based Learning Projects

Directory of Open Access Journals (Sweden)

Evode Mukama

2014-12-01

Full Text Available This paper depicts a study carried out in Rwanda concerning university students who participated in a contest to produce short documentary films. The purpose of this research is to conceptualize these kinds of technology-based learning projects (TBLPs through a sociocultural perspective. The methodology included focus-group discussions and field notes to collect empirical data. The findings reveal that the more educational technologies capture objects of learning positioned in the students’ sociocultural proximity, the more focused the learners’ attention is on these objects. The study shows also that a change in learning projects may depend to a large extent on whether the technology relates to the students’ sociocultural proximity, that is, taking into consideration students’ physical, cultural, and contextual real world. The study recommends a community of learning/inquiry embedded in a collaborative, problem-solving dynamic involving cognitive support from peers, teachers, external specialists, and the wider community.

Factors that Impact Software Project Success in Offshore Information Technology (IT) Companies

Science.gov (United States)

Edara, Venkatarao

2011-01-01

Information technology (IT) projects are unsuccessful at a rate of 65% to 75% per year, in spite of employing the latest technologies and training employees. Although many studies have been conducted on project successes in U.S. companies, there is a lack of research studying the impact of various factors on software project success in offshore IT…

LISA technologies in new light: exploring alternatives for charge management and optical bench construction

Science.gov (United States)

Ciani, Giacomo; Chilton, Andrew; Olatunde, Taiwo; Apple, Stephen; Conklin, John W.; Mueller, Guido

2015-08-01

A LISA-like gravitational wave observatory is the choice candidate for ESA's L3 large mission scheduled to launch in 2034. The LISA Test Package (LTP) mission will launch later this year and test many critical technologies needed for such an observatory, among which are picometer interferometry in space and UV charge management of the Test Mass (TM). The design of these subsystems has been frozen many years ago during the final formulation of the LTP mission; since then, the LISA mission concept has evolved and new technologies have become available, making it possible to re-think the way these subsystem are implemented. With the final formulation of the L3 mission still years in the future and the LTP results expected in about one year, now is an ideal time look for areas of possible improvement and explore alternative implementations that can enhance performance, reduce costs or mitigate risks.Recently developed UV LED are lighter, cheaper and more powerful than traditional mercury lamps; in addition, their fast response time can be used to implement AC discharge techniques that can save even more space and power, and provide a more precise control of the charge.The most recent iteration of the mission baseline design allows for eliminating some of the optical components initially deemed essential; paired with the use of polarization multiplexing, this permits a redesign of the optical bench that simplifies the layout and enables a modular approach to machining and assembly, thus reducing the risks and costs associated with the current monolithic design without compromising the picometer stability of the optical path.Leveraging on extensive previous experience with LISA interferometry and the availability of a torsion pendulum-based LISA test-bed, the University of Florida LISA group is working at developing, demonstrating and optimizing both these technologies. I will describe the most recent advancements and results.

Can CDM bring technology transfer to China?-An empirical study of technology transfer in China's CDM projects

International Nuclear Information System (INIS)

Wang Bo

2010-01-01

China has undertaken the greatest number of projects and reported the largest emission reductions on the global clean development mechanism (CDM) market. As technology transfer (TT) was designed to play a key role for Annex II countries in achieving greenhouse gas emission reductions, this study examines various factors that have affected CDM and TT in China. The proportion of total income derived from the certified emissions reductions (CER) plays a key role in the project owners' decision to adopt foreign technology. Incompatibility of CDM procedures with Chinese domestic procedures, technology diffusion (TD) effects, Chinese government policy and the role of carbon traders and CDM project consultants all contribute to the different degrees and forms of TT. International carbon traders and CDM consultants could play a larger role in TT in China's CDM projects as investors and brokers in the future.

Deploying innovative technologies to improve DOE D ampersand D project baselines

International Nuclear Information System (INIS)

Rose, R.W.

1997-05-01

The insertion of innovative technologies to replace baseline technologies used in cost estimation and planning of DOE D ampersand D projects is considered a high risk endeavor by project and programmatic decision makers. It is almost always considered safer to go with the open-quotes devil you knowclose quotes than use a new or untried technology, methodology or system. The decision on the specific technology to be utilized to remediate a problem is often made months or years in advance of execution, and the highly proscriptive documentation of agreements necessary to obtain stakeholder and regulator approval of remedial plans is often counterproductive to considering improved technologies

Ceramic Technology Project semiannual progress report, October 1992--March 1993

Energy Technology Data Exchange (ETDEWEB)

Johnson, D.R.

1993-09-01

This project was developed to meet the ceramic technology requirements of the OTS`s automotive technology programs. Although progress has been made in developing reliable structural ceramics, further work is needed to reduce cost. The work described in this report is organized according to the following work breakdown structure project elements: Materials and processing (monolithics [Si nitride, carbide], ceramic composites, thermal and wear coatings, joining, cost effective ceramic machining), materials design methodology (contact interfaces, new concepts), data base and life prediction (structural qualification, time-dependent behavior, environmental effects, fracture mechanics, nondestructive evaluation development), and technology transfer.

JUPITER PROJECT - MERGING INVERSE PROBLEM FORMULATION TECHNOLOGIES

Science.gov (United States)

The JUPITER (Joint Universal Parameter IdenTification and Evaluation of Reliability) project seeks to enhance and build on the technology and momentum behind two of the most popular sensitivity analysis, data assessment, calibration, and uncertainty analysis programs used in envi...

Information Technology in Engineering and Project Management

Directory of Open Access Journals (Sweden)

Chien-Ho Ko

2017-01-01

Full Text Available Information Technology (IT can be regarded as the use of computers to store, analyze, and manipulate data (Daintith, 2009. With the rapid development of personal computers, IT has been widely applied in nearly every field (Davenport, 2013. This issue presents five papers covering engineering and project management, three of which focus on the application of IT to solve engineering and project management issues, while one presents research into public private partnerships, and another into cash flow forecasting.

Integrated System Health Management (ISHM) Technology Demonstration Project Final Report

Science.gov (United States)

Mackey, Ryan; Iverson, David; Pisanich, Greg; Toberman, Mike; Hicks, Ken

2006-01-01

Integrated System Health Management (ISHM) is an essential capability that will be required to enable upcoming explorations mission systems such as the Crew Exploration Vehicle (CEV) and Crew Launch Vehicle (CLV), as well as NASA aeronautics missions. However, the lack of flight experience and available test platforms have held back the infusion by NASA Ames Research Center (ARC) and the Jet Propulsion Laboratory (JPL) of ISHM technologies into future space and aeronautical missions. To address this problem, a pioneer project was conceived to use a high-performance aircraft as a low-cost proxy to develop, mature, and verify the effectiveness of candidate ISHM technologies. Given the similarities between spacecraft and aircraft, an F/A-18 currently stationed at Dryden Flight Research Center (DFRC) was chosen as a suitable host platform for the test bed. This report describes how the test bed was conceived, how the technologies were integrated on to the aircraft, and how these technologies were matured during the project. It also describes the lessons learned during the project and a forward path for continued work.

The Plasma Hearth Process Technology Development Project

International Nuclear Information System (INIS)

Geimer, R.; Batdorf, J.; Wolfe, P.

1993-01-01

The US DOE Office of Technology Development (OTD) is currently evaluating the Plasma Hearth Process (PHP) for potential treatment of several DOE waste types. The PHP is a high-temperature vitrification process that has potential application for a wide range of mixed waste types in both the low-level and transuranic mixed waste categories. The PHP is being tested under both the OTD Mixed Waste Integrated Program and the Buried Waste Integrated Demonstration. Initial testing has been completed on several different surrogate waste forms that are representative of some of the DOE mixed waste streams. Destruction of organic material exceeds that of conventional incineration technologies. The vitrified residual has leaching characteristics comparable to glass formulations produced in the high-level waste program. The first phase of the PHP demonstration project has been successfully completed, and the project is currently beginning a comprehensive second phase of development and testing

Shippingport station decommissioning project technology transfer program

International Nuclear Information System (INIS)

Pasquini, L.A.

1986-01-01

The purpose of the Shippingport Station Decommissioning Project (SSDP) is to place the Shippingport Atomic Power Station in a long-term radiologically safe condition following defueling of the reactor, to perform decommissioning in such a manner as to demonstrate to the nuclear industry the application of decommissioning procedures to a large scale nuclear power plant, and to provide useful planning data for future decommissioning projects. This paper describes the Technology Transfer Program for collecting and archiving the decommissioning data base and its availability to the nuclear industry

DEVELOPMENTAL LEAD (PB) EXPOSURE REDUCES THE ABILITY OF THE NNDA ANTAGONIST MK801 TO SUPPRESS LONG-TERM POTENTIATION (LTP) IN THE RAT DENTATE GYRUS, IN VIVO

Science.gov (United States)

Chronic developmental lead (Pb) exposure increases the threshold and enhances decay of long-term potentiation (LTP) in the dentate gyrus of the hippocampal formation. MK-801 and other antagonists of the N-methyl-D-aspartate (NMDA) glutamate receptor subtype impair induction of LT...

Becoming Little Scientists: Technologically-Enhanced Project-Based Language Learning

Science.gov (United States)

Dooly, Melinda; Sadler, Randall

2016-01-01

This article outlines research into innovative language teaching practices that make optimal use of technology and Computer-Mediated Communication (CMC) for an integrated approach to Project-Based Learning. It is based on data compiled during a 10- week language project that employed videoconferencing and "machinima" (short video clips…

Numerical modeling in photonic crystals integrated technology: the COPERNICUS Project

DEFF Research Database (Denmark)

Malaguti, Stefania; Armaroli, Andrea; Bellanca, Gaetano

2011-01-01

Photonic crystals will play a fundamental role in the future of optical communications. The relevance of the numerical modeling for the success of this technology is assessed by using some examples concerning the experience of the COPERNICUS Project.......Photonic crystals will play a fundamental role in the future of optical communications. The relevance of the numerical modeling for the success of this technology is assessed by using some examples concerning the experience of the COPERNICUS Project....

Alignment and Testing of the GPRM as Part of the LTP Caging Mechanism

Science.gov (United States)

Koker, I.; Rozemeijer, H.; Stary, F.; Reichenberger, K.

2013-09-01

The GPRM (Grabbing, Position and Release Mechanism) is part of the Caging Mechanism (CM) and its electrical control unit (CCU) of the LISA Technology Package (LTP) on board ESA's LISA Pathfinder Spacecraft (LPF). The GPRM was only tested at sub-assembly level (one half on the mechanism) but never in assembled configuration on system level with the flight electronics (CCU). The developing company (RUAG Space, CH) was contracted with these limited activities.The GPRM EQM was successfully tested in 2008 and the two flight models were delivered in 2009. Due to design evolution of the CM, the flight GPRMs could not be tested in assembled configuration directly after their delivery. These GPRM system tests needed to be implemented in the upgraded CM design. In addition an alternative integration and alignment approach was developed taking advantage of the experience to date, which also resulted in an optimised schedule.As a consequence of the above mentioned starting point and the evolution of Caging Mechanism, the interface to the CM, an alternative alignment concept and verification approach of the GPRM needed to be developed and implemented by MAGNA Steyr Aerospace in close cooperation with all involved parties. The TV and functional test set-up was refurbished and pre-tests were performed such that the requirements could be verified. Vibration testing of the GPRM in its assembled and aligned configuration was different due to the new test and verification approach. New FEM models for the GPRM vibration test needed to be established and verified.Handling and operating the flight hardware, establishment of new alignment approaches and upgrade of test equipment for the new approach were the major challenges in this verification programme.This paper presents the alignment and testing activities of the GPRM together with its control electronics - the CCU.

Teachers’ Opinions Regarding the use of Technology in Education: Fatih Project Example

Directory of Open Access Journals (Sweden)

Esra KELEŞ

2013-12-01

Full Text Available Nowadays, projects were carried out in order to take basic steps which were necessary to meet the requirements of the information society. One of the projects is “Fatih Project” in Turkey. So, this study aims to present implications of the Fatih project in schools via teachers’ views. For this purpose case study was used and data were collected via semi structured interviews. Interview questions include; the use of related technologies, questioning the contribution of these technologies to the learning process and suggestions for the implementations of the project. By visiting Fatih project’s pilot schools 11 volunteer teachers who were active participant of the project were selected to participate in the study. Data gathered from the interviews were subjected to content analysis. As a result of the study, teachers have positive thoughts towards Fatih Project, especially for using interactive board. Beside teachers have negative thoughts and concerns towards the project in terms of in-service teacher education for using these technologies and providing content appropriate to the curriculum

Project-Based Learning in Electronic Technology: A Case Study

Science.gov (United States)

Li, Li

2015-01-01

A case study of project-based learning (PBL) implemented in Tianjin University of Technology and Education is presented. This multidiscipline project is innovated to meet the novel requirements of industry while keeping its traditional effectiveness in driving students to apply knowledge to practice and problem-solving. The implementation of PBL…

Using design science in educational technology research projects

Directory of Open Access Journals (Sweden)

Susan M. Chard

2017-12-01

Full Text Available Design science is a research paradigm where the development and evaluation of a technology artefact is a key contribution. Design science is used in many domains and this paper draws on those domains to formulate a generic structure for design science research suitable for educational technology research projects. The paper includes guidelines for writing proposals using the design science research methodology for educational technology research and presents a generic research report structure. The paper presents ethical issues to consider in design science research being conducted in educational settings and contributes guidelines for assessment when the research contribution involves the creation of a technology artefact.

The Role of Research in School Project Work and Teacher Development: Results from Project "Schools Ethics Technology."

Science.gov (United States)

Wellensiek, Anneliese; Lembens, Anja; Schallies, Michael

"Schools Ethics Technology" was a German interdisciplinary research project with the Centre of Ethics in the Sciences at the University of Tubingen. The project highlighted the new topic of biotechnology and genetic engineering, involving the formation of active project groups within schools. This study examined teaching activities…

Wireless Technology in the Library: The RIT Experience: Overview of the Project.

Science.gov (United States)

Pitkin, Pat

2001-01-01

Provides an overview of a project at RIT (Rochester Institute of Technology) that experimented with wireless technology, including laptop computers that circulate within the library building. Discusses project requirements, including ease of use, low maintenance, and low cost; motivation, including mobility; implementation; and benefits to the…

Venture Leaders Prize for innovative technology projects

CERN Multimedia

2006-01-01

In co-operation with the GEBERT RÜF FOUNDATION and the Ernest & Young Entrepreneur of the Year Award, venturelab will be presenting the Venture Leaders Prize. The Venture Leaders Prize, which is the new guise of the NETS (New Entrepreneurs in Technology and Science) Prize, will give twenty research entrepreneurs with projects to develop innovative technologies the opportunity to win the chance of participating in a programme to assist them in starting up their companies. The winners will go to spend 10 days in the Boston area (United States) where they will take part in a development programme for their project, which will include an entrepreneurship course, opportunities to meet start-up companies and financing experts, etc. This prize has already spawned many companies such as id Quantique, Selexis or ABMI which have contributed to the economic development of regions, particularly in French-speaking Switzerland. The competition is open to students and scientists from all fields, who would like to s...

ECUT (Energy Conversion and Utilization Technologies) program: Biocatalysis project

Science.gov (United States)

Baresi, Larry

1989-03-01

The Annual Report presents the fiscal year (FY) 1988 research activities and accomplishments, for the Biocatalysis Project of the U.S. Department of Energy, Energy Conversion and Utilization Technologies (ECUT) Division. The ECUT Biocatalysis Project is managed by the Jet Propulsion Laboratory, California Institute of Technology. The Biocatalysis Project is a mission-oriented, applied research and exploratory development activity directed toward resolution of the major generic technical barriers that impede the development of biologically catalyzed commercial chemical production. The approach toward achieving project objectives involves an integrated participation of universities, industrial companies and government research laboratories. The Project's technical activities were organized into three work elements: (1) The Molecular Modeling and Applied Genetics work element includes research on modeling of biological systems, developing rigorous methods for the prediction of three-dimensional (tertiary) protein structure from the amino acid sequence (primary structure) for designing new biocatalysis, defining kinetic models of biocatalyst reactivity, and developing genetically engineered solutions to the generic technical barriers that preclude widespread application of biocatalysis. (2) The Bioprocess Engineering work element supports efforts in novel bioreactor concepts that are likely to lead to substantially higher levels of reactor productivity, product yields and lower separation energetics. Results of work within this work element will be used to establish the technical feasibility of critical bioprocess monitoring and control subsystems. (3) The Bioprocess Design and Assessment work element attempts to develop procedures (via user-friendly computer software) for assessing the energy-economics of biocatalyzed chemical production processes, and initiation of technology transfer for advanced bioprocesses.

Benefits of applying low-temperature plasma treatment to wound care and hemostasis from the viewpoints of physics and pathology

Science.gov (United States)

Shimizu, Tetsuji; Ikehara, Yuzuru

2017-12-01

Over the last decade, low-temperature plasma (LTP) technology has reached the life sciences and introduced the benefits of using such technology at atmospheric pressure for medical applications. The active elements from LTP, such as reactive molecular species, charged particles and photons, appear to react with biomolecules on wounds and at bleeding points. This action by LTP might be analogous with semiconductor fabrication techniques such as etching and surface modification. From this perspective, we discuss the general aspects and principles of LTP devices used at atmospheric pressure in wound care and hemostasis as an interdisciplinary fusion of applied physics and pathology.

Study and Proposal of the Nuclear Power Plant Technology for the Ninh Thuan 2 Project

International Nuclear Information System (INIS)

Tran Chi Thanh; Le Van Hong; Hoang Sy Than; Nguyen Van De; Mai Dinh Trung; Nguyen Nhi Dien; Nguyen Minh Tuan; Pham Van Lam; Phan Ngoc Tuyen; Do Chi Dung; Hoang Minh Giang; Le Dai Dien

2015-01-01

The Ninh Thuan 1&2 Nuclear Power Plant Projects were approved on November 25th, 2009. At present, the task of NPP technology selection of these projects is an important and complex task. This report will show the acceptable method to create a set of criterion for selecting technology for Ninh Thuan 2 NPP project. The result of evaluation of three NPP technologies, such as ATMEA1, AP1000 and MPWR+ introduced in the Feasibility Study Reports of this project, will be discussed. In conclusion, the AP1000 technology is the first candidate for the Ninh Thuan 2 NPP Project. (author)

Ceramic Technology Project semiannual progress report, April 1992--September 1992

Energy Technology Data Exchange (ETDEWEB)

Johnson, D.R.

1993-07-01

This project was developed to meet the ceramic technology requirements of the DOE Office of Transportation Systems` automotive technology programs. Significant progress in fabricating ceramic components for DOE, NASA, and DOE advanced heat engine programs show that operation of ceramic parts in high-temperature engines is feasible; however, addition research is needed in materials and processing, design, and data base and life prediction before industry will have a sufficient technology base for producing reliable cost-effective ceramic engine components commercially. A 5-yr project plan was developed, with focus on structural ceramics for advanced gas turbine and diesel engines, ceramic bearings and attachments, and ceramic coatings for thermal barrier and wear applications in these engines.

Risk management in methodologies of information technology and communications projects

Directory of Open Access Journals (Sweden)

Jonathan Carrillo

2013-12-01

Full Text Available (Received: 2013/10/02 - Accepted: 2013/12/13At present there are methodologies that have several alternatives and methods to manage projects of Information and Communication Technologies. However, these do not cover a solution for the technology events that can occur in the industry, government, education, among others. In the technology market there are several models to identify and analyze risks according to relevant aspects of their area of specialty e.g. projects, in software development, communications, information security and business alignment. For this reason, this research conducted an evaluation of risk management activities of the methodologies used mostly to know which of them includes more correspondence with basic elements of IT using a rating scale.

Technology development projects in road infrastructure : The relevance of government championing behavior

NARCIS (Netherlands)

Caerteling, Jasper; Di Benedetto, Anthony; Doree, Andries G.; Halman, Johannes I.M.; Song, Michael

2011-01-01

Low-technology industries are largely neglected in technology management literature. Yet, recent studies show the crucial importance of innovation in low-technology industries. In this study, we analyze technology development projects in a specific low-technology industry, road infrastructure, being

Laboratory technology research - abstracts of FY 1997 projects

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-11-01

The Laboratory Technology Research (LTR) program supports high-risk, multidisciplinary research partnerships to investigate challenging scientific problems whose solutions have promising commercial potential. These partnerships capitalize on two great strengths of this country: the world-class basic research capability of the DOE Energy Research (ER) multi-program national laboratories and the unparalleled entrepreneurial spirit of American industry. A distinguishing feature of the ER multi-program national laboratories is their ability to integrate broad areas of science and engineering in support of national research and development goals. The LTR program leverages this strength for the Nation`s benefit by fostering partnerships with US industry. The partners jointly bring technology research to a point where industry or the Department`s technology development programs can pursue final development and commercialization. Projects supported by the LTR program are conducted by the five ER multi-program laboratories. These projects explore the applications of basic research advances relevant to DOE`s mission over a full range of scientific disciplines. The program presently emphasizes three critical areas of mission-related research: advanced materials; intelligent processing/manufacturing research; and sustainable environments.

Voices Project: Technological Innovations in Social Inclusion of People with Visual Impairment

Directory of Open Access Journals (Sweden)

Janaina Cazini

2013-04-01

Full Text Available This article aims to analyze how technological innovations are contributing to inclusion of people with disabilities in society and at work, from the study of social innovations, assistive technology and digital inclusion presented in a case study on the Voices Project. The project, developed in partnership with the Association of Parents and Friends of the Blind and the Federal Technological University of Paraná, in the years 2008/2009, made a computer course for people with visual impairments. The theoretical survey and project data confirmed that social innovations really are essential tools for digital inclusion of people with disabilities contributing thus to their inclusion in the workplace.

Status and Mission Applicability of NASA's In-Space Propulsion Technology Project

Science.gov (United States)

Anderson, David J.; Munk, Michelle M.; Dankanich, John; Pencil, Eric; Liou, Larry

2009-01-01

The In-Space Propulsion Technology (ISPT) project develops propulsion technologies that will enable or enhance NASA robotic science missions. Since 2001, the ISPT project developed and delivered products to assist technology infusion and quantify mission applicability and benefits through mission analysis and tools. These in-space propulsion technologies are applicable, and potentially enabling for flagship destinations currently under evaluation, as well as having broad applicability to future Discovery and New Frontiers mission solicitations. This paper provides status of the technology development, near-term mission benefits, applicability, and availability of in-space propulsion technologies in the areas of advanced chemical thrusters, electric propulsion, aerocapture, and systems analysis tools. The current chemical propulsion investment is on the high-temperature Advanced Material Bipropellant Rocket (AMBR) engine providing higher performance for lower cost. Investments in electric propulsion technologies focused on completing NASA's Evolutionary Xenon Thruster (NEXT) ion propulsion system, a 0.6-7 kW throttle-able gridded ion system, and the High Voltage Hall Accelerator (HiVHAC) thruster, which is a mid-term product specifically designed for a low-cost electric propulsion option. Aerocapture investments developed a family of thermal protections system materials and structures; guidance, navigation, and control models of blunt-body rigid aeroshells; atmospheric models for Earth, Titan, Mars and Venus; and models for aerothermal effects. In 2009 ISPT started the development of propulsion technologies that would enable future sample return missions. The paper describes the ISPT project's future focus on propulsion for sample return missions. The future technology development areas for ISPT is: Planetary Ascent Vehicles (PAV), with a Mars Ascent Vehicle (MAV) being the initial development focus; multi-mission technologies for Earth Entry Vehicles (MMEEV) needed

Summary of Industry-Academia Collaboration Projects on Cluster Ion Beam Process Technology

International Nuclear Information System (INIS)

Yamada, Isao; Toyoda, Noriaki; Matsuo, Jiro

2008-01-01

Processes employing clusters of ions comprised of a few hundred to many thousand atoms are now being developed into a new field of ion beam technology. Cluster-surface collisions produce important non-linear effects which are being applied to shallow junction formation, to etching and smoothing of semiconductors, metals, and dielectrics, to assisted formation of thin films with nano-scale accuracy, and to other surface modification applications. In 2000, a four year R and D project for development of industrial technology began in Japan under funding from the New Energy and Industrial Technology Development Organization (NEDO). Subjects of the projects are in areas of equipment development, semiconductor surface processing, high accuracy surface processing and high-quality film formation. In 2002, another major cluster ion beam project which emphasized nano-technology applications has started under a contract from the Ministry of Economy and Technology for Industry (METI). This METI project involved development related to size-selected cluster ion beam equipment and processes, and development of GCIB processes for very high rate etching and for zero damage etching of magnetic materials and compound semiconductor materials. This paper describes summery of the results.

Local participation in complex technological projects as bridging between different communities in Belgium

NARCIS (Netherlands)

Sips, K.; Craps, M.; Dewulf, A.

2013-01-01

Local community participation in complex technological projects, where technological innovations and risks need to be managed, is notoriously challenging. Relations with local inhabitants easily take the form of exclusion, protest, controversy or litigation. While such projects represent

The ECLSS Advanced Automation Project Evolution and Technology Assessment

Science.gov (United States)

Dewberry, Brandon S.; Carnes, James R.; Lukefahr, Brenda D.; Rogers, John S.; Rochowiak, Daniel M.; Mckee, James W.; Benson, Brian L.

1990-01-01

Viewgraphs on Environmental Control and Life Support System (ECLSS) advanced automation project evolution and technology assessment are presented. Topics covered include: the ECLSS advanced automation project; automatic fault diagnosis of ECLSS subsystems descriptions; in-line, real-time chemical and microbial fluid analysis; and object-oriented, distributed chemical and microbial modeling of regenerative environmental control systems description.

Waste-to-energy technologies and project implementation

CERN Document Server

Rogoff, Marc J

2011-01-01

This book covers in detail programs and technologies for converting traditionally landfilled solid wastes into energy through waste-to-energy projects. Modern Waste-to-Energy plants are being built around the world to reduce the levels of solid waste going into landfill sites and contribute to renewable energy and carbon reduction targets. The latest technologies have also reduced the pollution levels seen from early waste incineration plants by over 99 per cent. With case studies from around the world, Rogoff and Screve provide an insight into the different approaches taken to the planning and implementation of WTE. The second edition includes coverage of the latest technologies and practical engineering challenges as well as an exploration of the economic and regulatory context for the development of WTE.

The NASA In-Space Propulsion Technology Project, Products, and Mission Applicability

Science.gov (United States)

Anderson, David J.; Pencil, Eric; Liou, Larry; Dankanich, John; Munk, Michelle M.; Kremic, Tibor

2009-01-01

The In-Space Propulsion Technology (ISPT) Project, funded by NASA s Science Mission Directorate (SMD), is continuing to invest in propulsion technologies that will enable or enhance NASA robotic science missions. This overview provides development status, near-term mission benefits, applicability, and availability of in-space propulsion technologies in the areas of aerocapture, electric propulsion, advanced chemical thrusters, and systems analysis tools. Aerocapture investments improved: guidance, navigation, and control models of blunt-body rigid aeroshells; atmospheric models for Earth, Titan, Mars, and Venus; and models for aerothermal effects. Investments in electric propulsion technologies focused on completing NASA s Evolutionary Xenon Thruster (NEXT) ion propulsion system, a 0.6 to 7 kW throttle-able gridded ion system. The project is also concluding its High Voltage Hall Accelerator (HiVHAC) mid-term product specifically designed for a low-cost electric propulsion option. The primary chemical propulsion investment is on the high-temperature Advanced Material Bipropellant Rocket (AMBR) engine providing higher performance for lower cost. The project is also delivering products to assist technology infusion and quantify mission applicability and benefits through mission analysis and tools. In-space propulsion technologies are applicable, and potentially enabling for flagship destinations currently under evaluation, as well as having broad applicability to future Discovery and New Frontiers mission solicitations.

Airspace Technology Demonstration 3 (ATD-3): Applied Traffic Flow Management Project Overview

Science.gov (United States)

Gong, Chester

2016-01-01

ATD-3 Project Overview for 3rd Joint Workshop for KAIA-KARI - NASA ATM Research Collaboration. This presentation gives a high level description of the ATD-3 project and related technologies. These technologies include Multi-Flight Common Routes (MFCR), Traffic Aware Strategic Aircrew Requests (TASAR) and Dynamic Routes for Arrivals in Weather (DRAW).

Projection display technology and product trends

Science.gov (United States)

Kahn, Frederic J.

1999-05-01

Major technology and market trends that could generate a 20 billion dollar electronic projector market by 2010 are reviewed in the perspective of recent product introductions. A log linear analysis shows that the light outputs of benchmark transportable data video projectors have increased at a rate of almost 90 percent per year since 1993. The list prices of these same projectors have decreased at a rate of over 40 percent per year. The tradeoffs of light output vs. resolution and weight are illustrated. Recent trends in projector efficacy vs. year are discussed. Lumen output per dollar of list price is shown to be a useful market metric. Continued technical advances and innovations including higher throughput light valve technologies with integrated drivers, brighter light source, field sequential color, integrated- and micro-optical components, and aerospace materials are likely to sustain these trends. The new technologies will enable projection displays for entertainment and computer applications with unprecedented levels of performance, compactness, and cost-effectiveness.

Technology-base research project for electrochemical storage report for 1981

Science.gov (United States)

McLarnon, F.

1982-06-01

The technology base research (TBR) project which provides the applied reseach base that supports all electrochemical energy storage applications: electric vehicles, electric load leveling, storage of solar electricity, and energy and resource conservation is described. The TBR identifies electrochemical technologies with the potential to satisfy stringent performance and economic requirements and transfer them to industry for further development and scale up. The TBR project consists of four major elements: electrochemical systems research, supporting research, electrochemical processes, and fuel cells for transportation. Activities in these four project elements during 1981 are summarized. Information is included on: iron-air batteries; aluminum-air batteries; lithium-metal sulfide cells; materials development for various batteries; and the characteristics of an NH3-air alkaline fuel cell in a vehicle.

Key Technologies of the Hydraulic Structures of the Three Gorges Project

Directory of Open Access Journals (Sweden)

Xinqiang Niu

2016-09-01

Full Text Available To date, the Three Gorges Project is the largest hydro junction in the world. It is the key project for the integrated water resource management and development of the Changjiang River. The technology of the project, with its huge scale and comprehensive benefits, is extremely complicated, and the design difficulty is greater than that of any other hydro project in the world. A series of new design theories and methods have been proposed and applied in the design and research process. Many key technological problems regarding hydraulic structures have been overcome, such as a gravity dam with multi-layer large discharge orifices, a hydropower station of giant generating units, and a giant continual multi-step ship lock with a high water head.

Guide on Project Web Access of SFR R and D and Technology Monitoring System

International Nuclear Information System (INIS)

Lee, Dong Uk; Won, Byung Chool; Lee, Yong Bum; Kim, Young In; Hahn, Do Hee

2008-09-01

The SFR R and D and technology monitoring system based on the MS enterprise project management is developed for systematic effective management of 'Development of Basic Key Technologies for Gen IV SFR' project which was performed under the Mid- and Long-term Nuclear R and D Program sponsored by the Ministry of Education, Science and Technology. This system is a tool for project management based on web access. Therefore this manual is a detailed guide for Project Web Access(PWA). Section 1 describes the common guide for using of system functions such as project server 2007 client connection setting, additional outlook function setting etc. The section 2 describes the guide for system administrator. It is described the guide for project management in section 3, 4

Guide on Project Web Access of SFR R and D and Technology Monitoring System

Energy Technology Data Exchange (ETDEWEB)

Lee, Dong Uk; Won, Byung Chool; Lee, Yong Bum; Kim, Young In; Hahn, Do Hee

2008-09-15

The SFR R and D and technology monitoring system based on the MS enterprise project management is developed for systematic effective management of 'Development of Basic Key Technologies for Gen IV SFR' project which was performed under the Mid- and Long-term Nuclear R and D Program sponsored by the Ministry of Education, Science and Technology. This system is a tool for project management based on web access. Therefore this manual is a detailed guide for Project Web Access(PWA). Section 1 describes the common guide for using of system functions such as project server 2007 client connection setting, additional outlook function setting etc. The section 2 describes the guide for system administrator. It is described the guide for project management in section 3, 4.

Dry Rod Consolidation Technology Project results

International Nuclear Information System (INIS)

Mullen, C.K.; Feldman, E.M; Vinjamuri, K.; Griebenow, B.L.; Lynch, R.J.; Arave, A.E.; Hill, R.C.

1988-01-01

The Dry Rod Consolidation Technology (DRCT) Project conducted at the Idaho National Engineering Laboratory (INEL), in 1987 demonstrated the technical feasibility of a dry horizontal fuel rod consolidation process. Fuel rods from Westinghouse 15 /times/ 15 pressurized water reactor (PWR) spent fuel assemblies were consolidated into canisters to achieve a 2:1 volume reduction ratio. The consolidation equipment was operated at an existing hot cell complex at the INEL. The equipment was specifically designed to interface with the existing facility fuel handling and operational capabilities and was instrumented to provide data collection for process technology research. During the operational phase, data were collected from observation of the consolidation process, fuel assembly handling, and fuel rod behavior and characteristics. Equipment performance was recorded and data measurements were compiled on crud and contamination generated and spread. Fuel assembly skeletons [non-fuel bearing components (NFBC)] were gamma scanned and analyzed for isotopic content and profile. The above data collection was enhanced by extensive photograph and video documentation. The loaded consolidation fuel canisters were utilized for a test of the Transnuclear, Inc. TN-24P dry storage cask with consolidated fuel. The NFBC material was stored for a future volume reduction demonstration project. 14 figs., 4 tabs

Pipeline cost reduction through effective project management and applied technology

Energy Technology Data Exchange (ETDEWEB)

Jenkins, A. [TransCanada Pipeline Ltd., Alberta (Canada); Babuk, T. [Empress International Inc., Westwood, NJ (United States); Mohitpour, M. [Tempsys Pipeline Solutions Inc., Vancouver, BC (Canada); Murray, M.A. [National Energy Board of Canada (Canada)

2005-07-01

Pipelines are regarded by many as passive structures with the technology involved in their construction and operation being viewed as relatively simple and stable. If such is the case how can there be much room for cost improvement? In reality, there have been many technological and regulatory innovations required within the pipeline industry to meet the challenges posed by ever increasing consumer demand for hydrocarbons, the effects of aging infrastructure and a need to control operating and maintenance expenditures. The importance of technology management, as a subset of overall project management, is a key element of life cycle cost control. Assurance of public safety and the integrity of the system are other key elements in ensuring a successful pipeline project. The essentials of best practise project management from an owner/ operator's perspective are set out in the paper. Particular attention is paid to the appropriate introduction of new technology, strategic procurement practice and material selection, indicating that capital cost savings of up to 15% are achievable without harming life cycle cost. The value of partnering leading to technical innovation, cost savings and improved profitability for all the participants is described. Partnering also helps avoid duplicated effort through the use of common tools for design, planning schedule tracking and reporting. Investing in appropriate technology development has been a major source of cost reduction in recent years and the impact of a number of these recently introduced technologies in the areas of materials, construction processes and operation and maintenance are discussed in the paper. (author)

Didactics, Technology, and Organisation of Project Based Distance Education

DEFF Research Database (Denmark)

Knudsen, Morten Haack; Borch, Ole M.; Helbo, Jan

2005-01-01

The didactics, technology, and organization of an ICT supported distance engineering Master education are described. A systematic monitoring and evaluation of the basis year has given useful experience, subsequently used for adjustments and improvements. A successful on-campus project organized...... as asynchronous, which is possible with extensive utilization of new information and communication technology. Virtual meetings are conducted with text, sound and video based communication. Also the organization requires technology. A new learning management system, specifically designed to the didactic form...

Ceramic Technology Project, semiannual progress report for October 1993 through March 1994

Energy Technology Data Exchange (ETDEWEB)

Johnson, D.R.

1994-09-01

The Ceramic Technology Project was originally developed by the Department of Energy`s Office of Transportation Systems (OTS) in Conservation and Renewable Energy. Significant accomplishments in fabricating ceramic components for the Department of Energy (DOE), National Aeronautics and Space Administration (NASA), and Department of Defense (DoD) advanced heat engine programs have provided evidence that the operation of ceramic parts in high-temperature engine environments is feasible. An assessment of needs was completed, and a five-year project plan was developed with extensive input from private industry. In July 1990, the original plan was updated through the estimated completion of development in 1993. The original objective of the project was to develop the industrial technology base required for reliable ceramics for application in advanced automotive heat engines. During the course of the Ceramic Technology Project, remarkable progress has been made in the development of reliable structural ceramics. The direction of the Ceramic Technology Project is now shifting toward reducing the cost of ceramics to facilitate commercial introduction of ceramic components for near-term engine applications. In response to extensive input from industry, the plan is to extend the engine types which were previously supported (advanced gas turbine and low-heat-rejection diesel engines) to include near-term (5-10 years) applications in conventional automobile and diesel truck engines. To facilitate the rapid transfer of this technology to U.S. industry, the major portion of the work is being done in the ceramic industry, with technological support from government laboratories, other industrial laboratories, and universities. A systematic approach to reducing the cost of components is envisioned.

2017 NMC Technology Outlook for Nordic Schools A Horizon Project Regional Report

DEFF Research Database (Denmark)

2017-01-01

research effort between the New Media Consortium (NMC) and the Norwegian Centre for ICT in Education to inform Nordic school leaders and decision-makers about significant developments in technologies supporting teaching, learning, and creative inquiry in primary and secondary education across Denmark......Adams Becker, S., Cummins, M., Freeman, A., and Rose, K. (2017). 2017 NMC Technology Outlook for Nordic Schools: A Horizon Project Regional Report. Austin, Texas: The New Media Consortium. The 2017 NMC Technology Outlook for Nordic Schools: A Horizon Project Regional Report reflects a collaborative...

Study of Collaborative Management for Transportation Construction Project Based on BIM Technology

Science.gov (United States)

Jianhua, Liu; Genchuan, Luo; Daiquan, Liu; Wenlei, Li; Bowen, Feng

2018-03-01

Abstract. Building Information Modeling(BIM) is a building modeling technology based on the relevant information data of the construction project. It is an advanced technology and management concept, which is widely used in the whole life cycle process of planning, design, construction and operation. Based on BIM technology, transportation construction project collaborative management can have better communication through authenticity simulation and architectural visualization and can obtain the basic and real-time information such as project schedule, engineering quality, cost and environmental impact etc. The main services of highway construction management are integrated on the unified BIM platform for collaborative management to realize information intercommunication and exchange, to change the isolated situation of information in the past, and improve the level of information management. The final BIM model is integrated not only for the information management of project and the integration of preliminary documents and design drawings, but also for the automatic generation of completion data and final accounts, which covers the whole life cycle of traffic construction projects and lays a good foundation for smart highway construction.

New technologies for ammonium dinitramide based monopropellant thrusters - The project RHEFORM

Science.gov (United States)

Negri, Michele; Wilhelm, Marius; Hendrich, Christian; Wingborg, Niklas; Gediminas, Linus; Adelöw, Leif; Maleix, Corentin; Chabernaud, Pierre; Brahmi, Rachid; Beauchet, Romain; Batonneau, Yann; Kappenstein, Charles; Koopmans, Robert-Jan; Schuh, Sebastian; Bartok, Tobias; Scharlemann, Carsten; Gotzig, Ulrich; Schwentenwein, Martin

2018-02-01

New technologies are developed in the project RHEFORM to enable the replacement of hydrazine with liquid propellants based on ammonium dinitramide (ADN). The replacement of hydrazine with green propellants will make space propulsion more sustainable and better suitable for the requirements of future missions. In the RHEFORM project investigation on the composition of the propellants are conducted to enable the use of materials for catalysts and combustion chambers which are not subject to the International Traffic in Arms Regulations (ITAR). New igniters are under development aiming at a reduction of required energy and a more prompt ignition. Two different types of igniters are considered: improved catalytic igniters and thermal igniters. The technologies developed in RHEFORM will be implemented in two thruster demonstrators, aiming at a technology readiness level (TRL) of 5. In the present work the results obtained in the first half of the project are presented.

Conditioned taste aversion modifies persistently the subsequent induction of neocortical long-term potentiation in vivo.

Science.gov (United States)

Rodríguez-Durán, Luis F; Castillo, Diana V; Moguel-González, Minerva; Escobar, Martha L

2011-05-01

The ability of neurons to modify their synaptic strength in an activity-dependent manner has a crucial role in learning and memory processes. It has been proposed that homeostatic forms of plasticity might provide the global regulation necessary to maintain synaptic strength and plasticity within a functional dynamic range. Similarly, it is considered that the capacity of synapses to express plastic changes is itself subject to variation dependent on previous experience. In particular, training in several behavioral tasks modifies the possibility to induce long-term potentiation (LTP). Our previous studies in the insular cortex (IC) have shown that induction of LTP in the basolateral amygdaloid nucleus (Bla)-IC projection previous to conditioned taste aversion (CTA) training enhances the retention of this task. The aim of the present study was to analyze whether CTA training modifies the ability to induce subsequent LTP in the Bla-IC projection in vivo. Thus, CTA trained rats received high frequency stimulation in the Bla-IC projection in order to induce LTP 48, 72, 96 and 120 h after the aversion test. Our results show that CTA training prevents the subsequent induction of LTP in the Bla-IC projection, for at least 120 h after CTA training. We also showed that pharmacological inhibition of CTA consolidation with anisomycin (1 μl/side; 100 μg/μl) prevents the CTA effect on IC-LTP. These findings reveal that CTA training produces a persistent change in the ability to induce subsequent LTP in the Bla-IC projection in a protein-synthesis dependent manner, suggesting that changes in the ability to induce subsequent synaptic plasticity contribute to the formation and persistence of aversive memories. Copyright © 2011 Elsevier Inc. All rights reserved.

Barriers and Facilitators of Collaborative Management in Technological Innovation Projects

Directory of Open Access Journals (Sweden)

Sonia Regina Hierro Parolin

2013-05-01

Full Text Available Discussions about innovation tend to a more systemic and cooperative approach in which those networks focused on scientific and technological development are considered. This article aims to identify the barriers and facilitators in the collaborative management process of technological innovation projects and a study has been carried out by the cooperation action for innovation with 17 industries in Brazil. The primary evidence refers to the crucial role of project managers when leading the structural demands, and clarity on the relevance of the communication of strategic guidelines among the organizations involved for the achievement of the results in the industries.

The NutriChip project--translating technology into nutritional knowledge.

Science.gov (United States)

Vergères, Guy; Bogicevic, Biljana; Buri, Caroline; Carrara, Sandro; Chollet, Magali; Corbino-Giunta, Linda; Egger, Lotti; Gille, Doreen; Kopf-Bolanz, Katrin; Laederach, Kurt; Portmann, Reto; Ramadan, Qasem; Ramsden, Jeremy; Schwander, Flurina; Silacci, Paolo; Walther, Barbara; Gijs, Martin

2012-09-01

Advances in food transformation have dramatically increased the diversity of products on the market and, consequently, exposed consumers to a complex spectrum of bioactive nutrients whose potential risks and benefits have mostly not been confidently demonstrated. Therefore, tools are needed to efficiently screen products for selected physiological properties before they enter the market. NutriChip is an interdisciplinary modular project funded by the Swiss programme Nano-Tera, which groups scientists from several areas of research with the aim of developing analytical strategies that will enable functional screening of foods. The project focuses on postprandial inflammatory stress, which potentially contributes to the development of chronic inflammatory diseases. The first module of the NutriChip project is composed of three in vitro biochemical steps that mimic the digestion process, intestinal absorption, and subsequent modulation of immune cells by the bioavailable nutrients. The second module is a miniaturised form of the first module (gut-on-a-chip) that integrates a microfluidic-based cell co-culture system and super-resolution imaging technologies to provide a physiologically relevant fluid flow environment and allows sensitive real-time analysis of the products screened in vitro. The third module aims at validating the in vitro screening model by assessing the nutritional properties of selected food products in humans. Because of the immunomodulatory properties of milk as well as its amenability to technological transformation, dairy products have been selected as model foods. The NutriChip project reflects the opening of food and nutrition sciences to state-of-the-art technologies, a key step in the translation of transdisciplinary knowledge into nutritional advice.

Pharmacological Activators of the NR4A Nuclear Receptors Enhance LTP in a CREB/CBP-Dependent Manner.

Science.gov (United States)

Bridi, Morgan S; Hawk, Joshua D; Chatterjee, Snehajyoti; Safe, Stephen; Abel, Ted

2017-05-01

Nr4a nuclear receptors contribute to long-term memory formation and are required for long-term memory enhancement by a class of broad-acting drugs known as histone deacetylase (HDAC) inhibitors. Understanding the molecular mechanisms that regulate these genes and identifying ways to increase their activity may provide novel therapeutic approaches for ameliorating cognitive dysfunction. In the present study, we find that Nr4a gene expression after learning requires the cAMP-response element binding (CREB) interaction domain of the histone acetyltransferase CREB-binding protein (CBP). These gene expression deficits emerge at a time after learning marked by promoter histone acetylation in wild-type mice. Further, mutation of the CREB-CBP interaction domain reduces Nr4a promoter acetylation after learning. As memory enhancement by HDAC inhibitors requires CREB-CBP interaction and Nr4a gene function, these data support the notion that the balance of histone acetylation at the Nr4a promoters is critical for memory formation. NR4A ligands have recently been described, but the effect of these drugs on synaptic plasticity or memory has not been investigated. We find that the 'C-DIM' NR4A ligands, para-phenyl substituted di-indolylmethane compounds, enhance long-term contextual fear memory and increase the duration of long-term potentiation (LTP), a form of hippocampal synaptic plasticity. LTP enhancement by these drugs is eliminated in mice expressing a dominant negative form of NR4A and attenuated in mice with mutation of the CREB-CBP interaction domain. These data define the molecular connection between histone acetylation and Nr4a gene expression after learning. In addition, they suggest that NR4A-activating C-DIM compounds may serve as a potent and selective means to enhance memory and synaptic plasticity.

SIHTI 2. Energy and environmental technology. Yearbook 1995. Project presentations

International Nuclear Information System (INIS)

Korhonen, M.; Thun, R.

1997-01-01

Detrimental impacts of various energy production forms, their prevention and costs to enterprises and to the society are studied in the National Research Programme on Energy and Environmental Technology - SIHTI 2. For this evaluation work databases on Finland's energy production, fuels and boilers and emissions of various production forms are needed. This is one of the main subtasks of the SIHTI Programme. Development of methods and tools required for environmental decision making and for the assessment of environmental costs and testing of their usability and reliability are equally important. Emission measurements are a problem field that continuously sets new challenges. In addition to energy production and its environmental impacts, environmental issues of the woodprocessing industries form another important research field of SIHTI 2 programme. A common aim of both fields is to reduce emissions of detrimental substances, to recycle raw materials, and to minimise and reuse wastes. Research and development projects are being carried out by a number of universities of different fields of science and technology, by research organisations and enterprises, and many projects are realised in close co-operation. In 1995, the programme comprised 28 R and D projects by universities and 22 enterprise-led projects. Results of these projects are presented in this yearbook. Part of the research projects continued from the preceding year and part were new projects continuing in 1996

A Synthesis and Survey of Critical Success Factors for Computer Technology Projects

Science.gov (United States)

Baker, Ross A.

2012-01-01

The author investigated the existence of critical success factors for computer technology projects. Current research literature and a survey of experienced project managers indicate that there are 23 critical success factors (CSFs) that correlate with project success. The survey gathered an assessment of project success and the degree to which…

Differential Effects of HRAS Mutation on LTP-Like Activity Induced by Different Protocols of Repetitive Transcranial Magnetic Stimulation.

Science.gov (United States)

Dileone, Michele; Ranieri, Federico; Florio, Lucia; Capone, Fioravante; Musumeci, Gabriella; Leoni, Chiara; Mordillo-Mateos, Laura; Tartaglia, Marco; Zampino, Giuseppe; Di Lazzaro, Vincenzo

2016-01-01

Costello syndrome (CS) is a rare congenital disorder due to a G12S amino acid substitution in HRAS protoncogene. Previous studies have shown that Paired Associative Stimulation (PAS), a repetitive brain stimulation protocol inducing motor cortex plasticity by coupling peripheral nerve stimulation with brain stimulation, leads to an extremely pronounced motor cortex excitability increase in CS patients. Intermittent Theta Burst Stimulation (iTBS) represents a protocol able to induce motor cortex plasticity by trains of stimuli at 50 Hz. In healthy subjects PAS and iTBS produce similar after-effects in motor cortex excitability. Experimental models showed that HRAS-dependent signalling pathways differently affect LTP induced by different patterns of repetitive synaptic stimulation. We aimed to compare iTBS-induced after-effects on motor cortex excitability with those produced by PAS in CS patients and to observe whether HRAS mutation differentially affects two different forms of neuromodulation protocols. We evaluated in vivo after-effects induced by PAS and iTBS applied over the right motor cortex in 4 CS patients and in 21 healthy age-matched controls. Our findings confirmed HRAS-dependent extremely pronounced PAS-induced after-effects and showed for the first time that iTBS induces no change in MEP amplitude in CS patients whereas both protocols lead to an increase of about 50% in controls. CS patients are characterized by an impairment of iTBS-related LTP-like phenomena besides enhanced PAS-induced after-effects, suggesting that HRAS-dependent signalling pathways have a differential influence on PAS- and iTBS-induced plasticity in humans. Copyright © 2015 Elsevier Inc. All rights reserved.

Learning to make technology work - a study of learning in technology demonstration projects

DEFF Research Database (Denmark)

Sutherland Olsen, Dorothy; Andersen, Per Dannemand

2014-01-01

Building working demonstrations of new technologies within sustainable energy and transport has become an important activity in the move towards a more energy efficient society. The work involved in building these demonstrations is usually organised in a project with a variety of different partic...

Research on Green Construction Technology Applied at Guangzhou Hongding Building Project

Science.gov (United States)

Lou, Yong Zhong

2018-06-01

The green construction technology is the embodiment of sustainable development strategy in the construction industry, and it is a new construction mode which requires a higher environmental protection. Based on the Hongding building project, this paper describes the application and innovation of technical in the process of implementing green construction in the project, as well as the difficulties and characteristics in the specific practice; .The economic and social benefits of green construction are compared to the traditional construction model; .The achievements and experience of the green construction technology are summarized in the project; The ideas and methods in the process of implementing green construction are abstracted; some suggestions are put forward for the development of green construction.

Large-scale decontamination and decommissioning technology demonstration project at a former uranium metal production facility

International Nuclear Information System (INIS)

Martineit, R.A.; Borgman, T.D.; Peters, M.S.; Stebbins, L.L.

1997-01-01

The Department of Energy's (DOE) Office of Science and Technology Decontamination and Decommissioning (D ampersand D) Focus Area, led by the Federal Energy Technology Center, has been charged with improving upon baseline D ampersand D technologies with the goal of demonstrating and validating more cost-effective and safer technologies to characterize, deactivate, survey, decontaminate, dismantle, and dispose of surplus structures, buildings, and their contents at DOE sites. The D ampersand D Focus Area's approach to verifying the benefits of the improved D ampersand D technologies is to use them in large-scale technology demonstration (LSTD) projects at several DOE sites. The Fernald Environmental Management Project (FEMP) was selected to host one of the first three LSTD's awarded by the D ampersand D Focus Area. The FEMP is a DOE facility near Cincinnati, Ohio, that was formerly engaged in the production of high quality uranium metal. The FEMP is a Superfund site which has completed its RUFS process and is currently undergoing environmental restoration. With the FEMP's selection to host an LSTD, the FEMP was immediately faced with some challenges. The primary challenge was that this LSTD was to be integrated into the FEMP's Plant 1 D ampersand D Project which was an ongoing D ampersand D Project for which a firm fixed price contract had been issued to the D ampersand D Contractor. Thus, interferences with the baseline D ampersand D project could have significant financial implications. Other challenges include defining and selecting meaningful technology demonstrations, finding/selecting technology providers, and integrating the technology into the baseline D ampersand D project. To date, twelve technologies have been selected, and six have been demonstrated. The technology demonstrations have yielded a high proportion of open-quotes winners.close quotes All demonstrated, technologies will be evaluated for incorporation into the FEMP's baseline D ampersand D

An example of technological transfer to industry: the 'IMI' project

International Nuclear Information System (INIS)

Stefanini, A.; Amendolia, S.R.; Annovazzi, A.; Baldelli, P.; Bigongiari, A.; Bisogni, M.G.; Catarsi, F.; Cetronio, A.; Chianella, M.; Cinti, M.N.; Delogu, P.; Fantacci, M.E.; Galimberti, D.; Gambaccini, M.; Gilardoni, C.; Iurlaro, G.; Lanzieri, C.; Meoni, M.; Novelli, M.; Pani, R.; Passuello, G.; Pellegrini, R.; Pieracci, M.; Quattrocchi, M.; Rosso, V.; Venturelli, L.

2004-01-01

Several INFN Sections and Departments of Physics of Italian Universities have spent many man-years in the attempt to adapt detector and read-out technologies, originally developed in the field of High Energy Physics, to the domain of biomedical apparatuses. The research covered such areas as the exploitation of crystals for the production of monochromatic X-ray beams, the development of devices for efficient X-ray detection, the design of advanced VLSI electronics, the improvement of Position Sensitive Photomultiplier Tubes and crystals for Nuclear Medicine gamma-cameras. These studies have been integrated in the Integrated Mammographic Imaging (IMI) project, funded by the Italian Government through the law 46/82 (art.10) and is carried on by five high-technology industries in Italy, namely LABEN, CAEN, AMS, GILARDONI and POL.HI.TECH. We report on the status of this technological transfer project

Planning and leading of the technological processes by mechanical working with microsoft project

Science.gov (United States)

Nae, I.; Grigore, N.

2016-08-01

Nowadays, fabrication systems and methods are being modified; new processing technologies come up, flow sheets develop a minimum number of phases, the flexibility of the technologies grows up, new methods and instruments of monitoring and leading the processing operations also come up. The technological course (route, entry, scheme, guiding) referring to the series of the operation, putting and execution phases of a mark in order to obtain the final product from the blank is represented by a sequence of activities realized by a logic manner, on a well determined schedule, with a determined budget and resources. Also, a project can be defined as a series of specific activities, methodical structured which they aim to finish a specific objective, within a fixed schedule and budget. Within the homogeneity between the project and the technological course, this research is presenting the defining of the technological course of mechanical chip removing process using Microsoft Project. Under these circumstances, this research highlights the advantages of this method: the celerity using of other technological alternatives in order to pick the optimal process, the job scheduling being constrained by any kinds, the standardization of some processing technological operations.

RF Phase Reference Distribution System for the TESLA Technology Based Projects

CERN Document Server

Czuba, K; Romaniuk, R S

2013-01-01

Since many decades physicists have been building particle accelerators and usually new projects became more advanced, more complicated and larger than predecessors. The importance and complexity of the phase reference distribution systems used in these accelerators have grown significantly during recent years. Amongst the most advanced of currently developed accelerators are projects based on the TESLA technology. These projects require synchronization of many RF devices with accuracy reaching femtosecond levels over kilometre distances. Design of a phase reference distribution system fulfilling such requirements is a challenging scientific task. There are many interdisciplinary problems which must be solved during the system design. Many, usually negligible issues, may became very important in such system. Furthermore, the design of a distribution system on a scale required for the TESLA technology based projects is a new challenge and there is almost no literature sufficiently covering this subject. This th...

Miniaturized Power Processing Unit Study: A Cubesat Electric Propulsion Technology Enabler Project

Science.gov (United States)

Ghassemieh, Shakib M.

2014-01-01

This study evaluates High Voltage Power Processing Unit (PPU) technology and driving requirements necessary to enable the Microfluidic Electric Propulsion technology research and development by NASA and university partners. This study provides an overview of the state of the art PPU technology with recommendations for technology demonstration projects and missions for NASA to pursue.

Fire-Protection Research for Energy-Technology Projects: FY 1981 year-end report

Energy Technology Data Exchange (ETDEWEB)

Hasegawa, H.K.; Alvares, N.J.; Lipska-Quinn, A.E.; Beason, D.G.; Foote, K.L.; Priante, S.J.

1982-07-20

This report summarizes research conducted in fiscal year 1981 for the DOE-supported project, Fire Protection Research for Energy Technology Projects. Initiated in 1977, this ongoing research program was conceived to advance fire protection strategies for Energy Technology Projects to keep abreast of the unique fire problems that are developing with the complexity of energy technology research. We are developing an analytical methodology through detailed study of fusion energy experiments at Lawrence Livermore National Laboratory (LLNL). Employing these facilities as models for methodology development, we are simultaneously advancing three major task areas: (1) determination of unique fire hazards of current fusion energy facilities; (2) evaluation of the ability of accepted fire management measures to meet and negate hazards; and (3) performance of unique research into problem areas we have identified to provide input into analytical fire-growth and damage-assessment models.

Fire-Protection Research for Energy-Technology Projects: FY 1981 year-end report

International Nuclear Information System (INIS)

Hasegawa, H.K.; Alvares, N.J.; Lipska-Quinn, A.E.; Beason, D.G.; Foote, K.L.; Priante, S.J.

1982-01-01

This report summarizes research conducted in fiscal year 1981 for the DOE-supported project, Fire Protection Research for Energy Technology Projects. Initiated in 1977, this ongoing research program was conceived to advance fire protection strategies for Energy Technology Projects to keep abreast of the unique fire problems that are developing with the complexity of energy technology research. We are developing an analytical methodology through detailed study of fusion energy experiments at Lawrence Livermore National Laboratory (LLNL). Employing these facilities as models for methodology development, we are simultaneously advancing three major task areas: (1) determination of unique fire hazards of current fusion energy facilities; (2) evaluation of the ability of accepted fire management measures to meet and negate hazards; and (3) performance of unique research into problem areas we have identified to provide input into analytical fire-growth and damage-assessment models

Space science technology: In-situ science. Sample Acquisition, Analysis, and Preservation Project summary

Science.gov (United States)

Aaron, Kim

1991-01-01

The Sample Acquisition, Analysis, and Preservation Project is summarized in outline and graphic form. The objective of the project is to develop component and system level technology to enable the unmanned collection, analysis and preservation of physical, chemical and mineralogical data from the surface of planetary bodies. Technology needs and challenges are identified and specific objectives are described.

Integrated technology projects for rural communities

Energy Technology Data Exchange (ETDEWEB)

Forestier-Walker, C O

1982-10-01

Integrated Technology Projects (ITP) are set up so that they interact concurrently in ways that are compatible with local cultures, religions, traditions, and life styles. This management approach can take into account the low productivity of arid and semi-arid regions by increasing water, power, and fertilizer inputs in ways that will integrate their supply with other activities and minimize costs. The author illustrates how integrated agricultural, water and sanitation, energy, and housing modules can accomplish this. 1 reference, 4 figures, 5 tables. (DCK)

Success probability orientated optimization model for resource allocation of the technological innovation multi-project system

Institute of Scientific and Technical Information of China (English)

Weixu Dai; Weiwei Wu; Bo Yu; Yunhao Zhu

2016-01-01

A success probability orientated optimization model for resource al ocation of the technological innovation multi-project system is studied. Based on the definition of the technological in-novation multi-project system, the leveling optimization of cost and success probability is set as the objective of resource al ocation. The cost function and the probability function of the optimization model are constructed. Then the objective function of the model is constructed and the solving process is explained. The model is applied to the resource al ocation of an enterprise’s technological innovation multi-project system. The results show that the pro-posed model is more effective in rational resource al ocation, and is more applicable in maximizing the utility of the technological innovation multi-project system.

Risk Management in Information Technology Project: An Empirical Study

Directory of Open Access Journals (Sweden)

Kornelius Irfandhi

2016-09-01

Full Text Available The companies are facing some risks due to changes in a dynamic environment. If risks are not managed properly, it will have some negative impacts on the companies at the present and the future. One important function of the Information Technology (IT governance is risk management. Risk management in IT project aims to provide a safe environment for IT projects undertaken. Risk management becomes an important process for the success of IT projects. This article discussed the risk of IT project and whether there was a relationship between risk management and the success of the project. The method used was performing a literature review of several scientific articles which published between 2010 and 2014. The results of this study are the presence of risk management and risk manager influence the success of the project. Risk analysis and risk monitoring and control also have a relationship with the subjective performance of IT projects. If risk management is applied properly, the chance of the success of the projects undertaken can be increased. 

Tension Awareness of Stakeholders in Large Technology Projects : A Duality Perspective

NARCIS (Netherlands)

Boonstra, Albert; van Offenbeek, Marjolein; Vos, Janita F.J.

2017-01-01

This article analyzes the tensions evolving from project management dilemmas and how they relate to stakeholders in large technology projects. The study addresses an organization-wide electronic health record implementation in a large hospital. It adopts a duality lens in exploring whether and how

Bringing Technology to Students' Proximity: A Sociocultural Account of Technology-Based Learning Projects

Science.gov (United States)

Mukama, Evode

2014-01-01

This paper depicts a study carried out in Rwanda concerning university students who participated in a contest to produce short documentary films. The purpose of this research is to conceptualize these kinds of technology-based learning projects (TBLPs) through a sociocultural perspective. The methodology included focus group discussions and field…

The Advanced Linked Extended Reconnaissance & Targeting Technology Demonstration project

Science.gov (United States)

Edwards, Mark

2008-04-01

The Advanced Linked Extended Reconnaissance & Targeting (ALERT) Technology Demonstration (TD) project is addressing many operational needs of the future Canadian Army's Surveillance and Reconnaissance forces. Using the surveillance system of the Coyote reconnaissance vehicle as an experimental platform, the ALERT TD project aims to significantly enhance situational awareness by fusing multi-sensor and tactical data, developing automated processes, and integrating beyond line-of-sight sensing. The project is exploiting important advances made in computer processing capability, displays technology, digital communications, and sensor technology since the design of the original surveillance system. As the major research area within the project, concepts are discussed for displaying and fusing multi-sensor and tactical data within an Enhanced Operator Control Station (EOCS). The sensor data can originate from the Coyote's own visible-band and IR cameras, laser rangefinder, and ground-surveillance radar, as well as from beyond line-of-sight systems such as mini-UAVs and unattended ground sensors. Video-rate image processing has been developed to assist the operator to detect poorly visible targets. As a second major area of research, automatic target cueing capabilities have been added to the system. These include scene change detection, automatic target detection and aided target recognition algorithms processing both IR and visible-band images to draw the operator's attention to possible targets. The merits of incorporating scene change detection algorithms are also discussed. In the area of multi-sensor data fusion, up to Joint Defence Labs level 2 has been demonstrated. The human factors engineering aspects of the user interface in this complex environment are presented, drawing upon multiple user group sessions with military surveillance system operators. The paper concludes with Lessons Learned from the project. The ALERT system has been used in a number of C4ISR

Management of a science and technology popularization project in the nuclear area

Energy Technology Data Exchange (ETDEWEB)

Soares, Wellington Antonio; Maretti Junior, Fausto [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)]. E-mail: soaresw@cdtn.br; fmj@cdtn.br

2007-07-01

The goal of this paper is to show the management results of the 2005-2007 project 'Nuclear energy: itinerant expositions' sponsored by the Foundation for Research Support of Minas Gerais (FAPEMIG), a state agency, in a science and technology popularization program. The project coordinated by the Nuclear Technology Development Center (CDTN/CNEN) in partnership with the Minas Commerce Association (ACMinas) was designed to students from public high school of the Belo Horizonte metropolitan region. It consisted of an exposition and a previous talk motivating the audience to the nuclear technology in connection with subjects taught at schools, like physics, chemistry, biology, mathematics, history, etc. Small scale models of nuclear and radioactive installations, irradiated food and fruits samples and colored gems by gamma rays were presented at the stand exposition. Designing, performing and evaluating the project required the following activities: searching of information on the target public, infrastructure mounting, team training, multimedia material elaboration, strategy for dealing with the students, talk presentation, distribution of booklet on nuclear themes, reception at the exposition, interviews with students and teachers by journalists, evaluation of the project by the schools, evaluation of the project by some students three months after the event and also reporting the project to the media. About forty people of CDTN took part in the project that reached thirty high schools and encompassed about 11,000 students. About five hundred state high school teachers of chemistry, physics and biology were reached by the experience of the project in a specialization course given by a local university. Only high approval was received by the project in the returned questionnaires. (author)

Management of a science and technology popularization project in the nuclear area

International Nuclear Information System (INIS)

Soares, Wellington Antonio; Maretti Junior, Fausto

2007-01-01

The goal of this paper is to show the management results of the 2005-2007 project 'Nuclear energy: itinerant expositions' sponsored by the Foundation for Research Support of Minas Gerais (FAPEMIG), a state agency, in a science and technology popularization program. The project coordinated by the Nuclear Technology Development Center (CDTN/CNEN) in partnership with the Minas Commerce Association (ACMinas) was designed to students from public high school of the Belo Horizonte metropolitan region. It consisted of an exposition and a previous talk motivating the audience to the nuclear technology in connection with subjects taught at schools, like physics, chemistry, biology, mathematics, history, etc. Small scale models of nuclear and radioactive installations, irradiated food and fruits samples and colored gems by gamma rays were presented at the stand exposition. Designing, performing and evaluating the project required the following activities: searching of information on the target public, infrastructure mounting, team training, multimedia material elaboration, strategy for dealing with the students, talk presentation, distribution of booklet on nuclear themes, reception at the exposition, interviews with students and teachers by journalists, evaluation of the project by the schools, evaluation of the project by some students three months after the event and also reporting the project to the media. About forty people of CDTN took part in the project that reached thirty high schools and encompassed about 11,000 students. About five hundred state high school teachers of chemistry, physics and biology were reached by the experience of the project in a specialization course given by a local university. Only high approval was received by the project in the returned questionnaires. (author)

Survey on the Technology Readiness Level of R and D projects for a Technical Risk Management

International Nuclear Information System (INIS)

Song, S. J.; Chang, J.; Lee, K. Y.

2008-01-01

The purpose of applying the Technology Readiness Level/Design Readiness Level (TRL/DRL) in technical risk management is to make technology assessments, and improve communication among researchers with a consistent, systematic technology readiness Technical risk management for the Nuclear Hydrogen Production project was adopted of experience assessed with Delphi Method from the Next Generation Nuclear Plant(NGNP)of the DOE to improve the poor contactor management of the major projects which experienced cost increases and/or schedule delays in long-term. In the current phase that is doing key technology research and development projects, the technology readiness level was reviewed and applied to the Nuclear Hydrogen Production project to prepare an input for the next design phases. Based on the previous works, pre-conceptional design and key R and D works for the Nuclear Hydrogen Design and Development(NHDD) projects and the results of key research and development projects, the TRL was applied to assess the levels and compared with the advanced design stages of Westinghouse Electric Co. With this process, several issues were identified to apply the design and technology level to the familiar steps of design process and research and development projects. In order to resolve these issues, it is needed to systematically adjust and modify the current process with TRLs

The Learning Process and Technological Change in Wind Power: Evidence from China's CDM Wind Projects

Science.gov (United States)

Tang, Tian; Popp, David

2016-01-01

The Clean Development Mechanism (CDM) is a project-based carbon trade mechanism that subsidizes the users of climate-friendly technologies and encourages technology transfer. The CDM has provided financial support for a large share of Chinese wind projects since 2002. Using pooled cross-sectional data of 486 registered CDM wind projects in China…

REGULATORY FUNDAMENTALS FOR IMPLEMENTATION OF INFORMATION TECHNOLOGY PROJECTS IN INDUSTRY

Directory of Open Access Journals (Sweden)

L. V. Gubich

2016-01-01

Full Text Available The article provides an overview of the existing regulatory basis for the development of IIST. The features of IT projects management and a brief description of methodological recommendations on implementation of IT projects of the State scientific and technical Program «Electronic enterprise resource planning (CALS-ERP-technology» for 2011–2015 are considered.

Exploring the Relationship between Authentic Leadership and Project Outcomes and Job Satisfaction with Information Technology Professionals

Science.gov (United States)

Fischer, Mark A.

2014-01-01

One of the most important issues for organizations and information technology (IT) professionals is measuring the success or failure of information technology projects. How we understand the value and usefulness of IT projects is critical to how information technology executives evaluate and decide on technology investments. In a 2009 CHAOS…

CO2 CAPTURE PROJECT - AN INTEGRATED, COLLABORATIVE TECHNOLOGY DEVELOPMENT PROJECT FOR NEXT GENERATION CO2 SEPARATION, CAPTURE AND GEOLOGIC SEQUESTRATION

Energy Technology Data Exchange (ETDEWEB)

Dr. Helen Kerr

2003-08-01

The CO{sub 2} Capture Project (CCP) is a joint industry project, funded by eight energy companies (BP, ChevronTexaco, EnCana, Eni, Norsk Hydro, Shell, Statoil, and Suncor) and three government agencies (1) European Union (DG Res & DG Tren), (2) Norway (Klimatek) and (3) the U.S.A. (Department of Energy). The project objective is to develop new technologies, which could reduce the cost of CO{sub 2} capture and geologic storage by 50% for retrofit to existing plants and 75% for new-build plants. Technologies are to be developed to ''proof of concept'' stage by the end of 2003. The project budget is approximately $24 million over 3 years and the work program is divided into eight major activity areas: (1) Baseline Design and Cost Estimation--defined the uncontrolled emissions from each facility and estimate the cost of abatement in $/tonne CO{sub 2}. (2) Capture Technology, Post Combustion: technologies, which can remove CO{sub 2} from exhaust gases after combustion. (3) Capture Technology, Oxyfuel: where oxygen is separated from the air and then burned with hydrocarbons to produce an exhaust with high CO{sub 2} for storage. (4) Capture Technology, Pre -Combustion: in which, natural gas and petroleum coke are converted to hydrogen and CO{sub 2} in a reformer/gasifier. (5) Common Economic Model/Technology Screening: analysis and evaluation of each technology applied to the scenarios to provide meaningful and consistent comparison. (6) New Technology Cost Estimation: on a consistent basis with the baseline above, to demonstrate cost reductions. (7) Geologic Storage, Monitoring and Verification (SMV): providing assurance that CO{sub 2} can be safely stored in geologic formations over the long term. (8) Non-Technical: project management, communication of results and a review of current policies and incentives governing CO{sub 2} capture and storage. Technology development work dominated the past six months of the project. Numerous studies are making

Commercial Supersonics Technology Project - Status of Airport Noise

Science.gov (United States)

Bridges, James

2016-01-01

The Commercial Supersonic Technology Project has been developing databases, computational tools, and system models to prepare for a level 1 milestone, the Low Noise Propulsion Tech Challenge, to be delivered Sept 2016. Steps taken to prepare for the final validation test are given, including system analysis, code validation, and risk reduction testing.

Foundations of low-temperature plasma enhanced materials synthesis and etching

Science.gov (United States)

Oehrlein, Gottlieb S.; Hamaguchi, Satoshi

2018-02-01

Low temperature plasma (LTP)-based synthesis of advanced materials has played a transformational role in multiple industries, including the semiconductor industry, liquid crystal displays, coatings and renewable energy. Similarly, the plasma-based transfer of lithographically defined resist patterns into other materials, e.g. silicon, SiO2, Si3N4 and other electronic materials, has led to the production of nanometer scale devices that are the basis of the information technology, microsystems, and many other technologies based on patterned films or substrates. In this article we review the scientific foundations of both LTP-based materials synthesis at low substrate temperature and LTP-based isotropic and directional etching used to transfer lithographically produced resist patterns into underlying materials. We cover the fundamental principles that are the basis of successful application of the LTP techniques to technological uses and provide an understanding of technological factors that may control or limit material synthesis or surface processing with the use of LTP. We precede these sections with a general discussion of plasma surface interactions, the LTP-generated particle fluxes including electrons, ions, radicals, excited neutrals and photons that simultaneously contact and modify surfaces. The surfaces can be in the line of sight of the discharge or hidden from direct interaction for structured substrates. All parts of the article are extensively referenced, which is intended to help the reader study the topics discussed here in more detail.

NASA Subsonic Rotary Wing Project-Multidisciplinary Analysis and Technology Development: Overview

Science.gov (United States)

Yamauchi, Gloria K.

2009-01-01

This slide presentation reviews the objectives of the Multidisciplinary Analysis and Technology Development (MDATD) in the Subsonic Rotary Wing project. The objectives are to integrate technologies and analyses to enable advanced rotorcraft and provide a roadmap to guide Level 1 and 2 research. The MDATD objectives will be met by conducting assessments of advanced technology benefits, developing new or enhanced design tools, and integrating Level 2 discipline technologies to develop and enable system-level analyses and demonstrations.

Propulsion Noise Reduction Research in the NASA Advanced Air Transport Technology Project

Science.gov (United States)

Van Zante, Dale; Nark, Douglas; Fernandez, Hamilton

2017-01-01

The Aircraft Noise Reduction (ANR) sub-project is focused on the generation, development, and testing of component noise reduction technologies progressing toward the NASA far term noise goals while providing associated near and mid-term benefits. The ANR sub-project has efforts in airframe noise reduction, propulsion (including fan and core) noise reduction, acoustic liner technology, and propulsion airframe aeroacoustics for candidate conventional and unconventional aircraft configurations. The current suite of propulsion specific noise research areas is reviewed along with emerging facility and measurement capabilities. In the longer term, the changes in engine and aircraft configuration will influence the suite of technologies necessary to reduce noise in next generation systems.

How Undergraduate Students Use Social Media Technologies to Support Group Project Work

Science.gov (United States)

McAliney, Peter J.

2013-01-01

Technology continues to evolve and become accessible to students in higher education. Concurrently, teamwork has become an important skill in academia and the workplace and students have adopted established technologies to support their learning in both individual and team project work. Given the emergence of social media technologies, I examined…

Implementing Biogas Technology Project in Malvar, Batangas, Philippines

Directory of Open Access Journals (Sweden)

Juvy G. Mojares

2015-11-01

Full Text Available This study sought to determine the environmental and social impacts of the biogas technology project of the municipal government of Malvar, Batangas, Philippines, through the Municipal Environment and Natural Resources Office. Document analysis and interview were employed in this study. Results showed that heat and electricity generation from biogas decreased dependency on electricity and fuel oil.In terms of social impacts, the biogas technology contributed to socio-economic improvement of the barangay in the form of job creation, technological and skills transfer through training in biogas production, contribution to continuous pursuing of energy neutrality and encouraged sustainability development at the community level. Aside from these, the technology was a source of organic fertilizer for the farming community of Malvar. It is recommended that commercial farms be strictly monitored and ordinances be imposed on them specifically on the use of biogas technology. The municipal government could partner with GOs and NGOs providing grant or equipment for such technology. For the monitoring of backyard farms, develop close coordination with barangay officials, if it does not work, plan a consultative meeting with agencies concerned to explain the hazards of improper disposal of hog wastes.

Project A+ Elementary Technology Demonstration Schools 1990-91. The First Year.

Science.gov (United States)

Marable, Paula; Frazer, Linda

Project A+ Elementary Technology Demonstration Schools is a program made possible through grants from IBM (International Business Machines Corporation) and Apple, Inc. The primary purpose of the program is to demonstrate the educational effectiveness of technology in accelerating the learning of low achieving at-risk students and enhancing the…

Electronic-projecting Moire method applying CBR-technology

Science.gov (United States)

Kuzyakov, O. N.; Lapteva, U. V.; Andreeva, M. A.

2018-01-01

Electronic-projecting method based on Moire effect for examining surface topology is suggested. Conditions of forming Moire fringes and their parameters’ dependence on reference parameters of object and virtual grids are analyzed. Control system structure and decision-making subsystem are elaborated. Subsystem execution includes CBR-technology, based on applying case base. The approach related to analysing and forming decision for each separate local area with consequent formation of common topology map is applied.

SmartPark Technology Demonstration Project, Phase II: Final Report

Science.gov (United States)

2018-05-01

The purpose of FMCSA's SmartPark project was to determine the feasibility of a technology for providing truck parking space availability information in real time to truckers on the road. SmartPark consisted of two phases. Phase I was a field operatio...

Expert system for economic evaluation of technological projects

Directory of Open Access Journals (Sweden)

Bohumil Hlavenka

2001-01-01

Full Text Available Apart from the technical level, a basic tool for decision-making and realization of the technical innovation project is also its economic effectiveness. It is assessed by comparing expenses and effects with respect to all-society interests and standards valid in a relevant period for the areas of technology, economy, ecology, safety of work, etc.

Project Morpheus: Lean Development of a Terrestrial Flight Testbed for Maturing NASA Lander Technologies

Science.gov (United States)

Devolites, Jennifer L.; Olansen, Jon B.

2015-01-01

NASA's Morpheus Project has developed and tested a prototype planetary lander capable of vertical takeoff and landing that is designed to serve as a testbed for advanced spacecraft technologies. The lander vehicle, propelled by a Liquid Oxygen (LOX)/Methane engine and sized to carry a 500kg payload to the lunar surface, provides a platform for bringing technologies from the laboratory into an integrated flight system at relatively low cost. In 2012, Morpheus began integrating the Autonomous Landing and Hazard Avoidance Technology (ALHAT) sensors and software onto the vehicle in order to demonstrate safe, autonomous landing and hazard avoidance. From the beginning, one of goals for the Morpheus Project was to streamline agency processes and practices. The Morpheus project accepted a challenge to tailor the traditional NASA systems engineering approach in a way that would be appropriate for a lower cost, rapid prototype engineering effort, but retain the essence of the guiding principles. This paper describes the tailored project life cycle and systems engineering approach for the Morpheus project, including the processes, tools, and amount of rigor employed over the project's multiple lifecycles since the project began in fiscal year (FY) 2011.

DLP-based 3D metrology by structured light or projected fringe technology for life sciences and industrial metrology

Science.gov (United States)

Frankowski, G.; Hainich, R.

2009-02-01

Since the mid-eighties, a fundamental idea for achieving measuring accuracy in projected fringe technology was to consider the projected fringe pattern as an interferogram and evaluate it on the basis of advanced algorithms widely used for phase measuring in real-time interferometry. A fundamental requirement for obtaining a sufficiently high degree of measuring accuracy with this so-called "phase measuring projected fringe technology" is that the projected fringes, analogous to interference fringes, must have a cos2-shaped intensity distribution. Until the mid-nineties, this requirement for the projected fringe pattern measurement technology presented a basic handicap for its wide application in 3D metrology. This situation changed abruptly, when in the nineties Texas Instruments introduced to the market advanced digital light projection on the basis of micro mirror based projection systems, socalled DLP technology, which also facilitated the generation and projection of cos2-shaped intensity and/or fringe patterns. With this DLP technology, which from its original approach was actually oriented towards completely different applications such as multimedia projection, Texas Instruments boosted phase-measuring fringe projection in optical 3D metrology to a worldwide breakthrough both for medical as well as industrial applications. A subject matter of the lecture will be to present the fundamental principles and the resulting advantages of optical 3D metrology based on phase-measuring fringe projection using DLP technology. Further will be presented and discussed applications of the measurement technology in medical engineering and industrial metrology.

An integrated ball projection technology for the study of dynamic interceptive actions.

Science.gov (United States)

Stone, J A; Panchuk, D; Davids, K; North, J S; Fairweather, I; Maynard, I W

2014-12-01

Dynamic interceptive actions, such as catching or hitting a ball, are important task vehicles for investigating the complex relationship between cognition, perception, and action in performance environments. Representative experimental designs have become more important recently, highlighting the need for research methods to ensure that the coupling of information and movement is faithfully maintained. However, retaining representative design while ensuring systematic control of experimental variables is challenging, due to the traditional tendency to employ methods that typically involve use of reductionist motor responses such as buttonpressing or micromovements. Here, we outline the methodology behind a custom-built, integrated ball projection technology that allows images of advanced visual information to be synchronized with ball projection. This integrated technology supports the controlled presentation of visual information to participants while they perform dynamic interceptive actions. We discuss theoretical ideas behind the integration of hardware and software, along with practical issues resolved in technological design, and emphasize how the system can be integrated with emerging developments such as mixed reality environments. We conclude by considering future developments and applications of the integrated projection technology for research in human movement behaviors.

Use of communication technologies in document exchange for the management of construction projects

Directory of Open Access Journals (Sweden)

Mesároš Peter

2016-06-01

Full Text Available Information and communication technologies represent a set of people, processes, technical and software tools providing collection, transport, storage and processing of data for distribution and presentation of information. Particularly communication systems are the main tool for information exchange. Of the other part, these technologies have a broad focus and use. One of them is the exchange of documents in the management of construction projects. Paper discusses the issue of exploitation level of communication technologies in construction project management. The main objective of this paper is to analyze exploitation level of communication technologies. Another aim of the paper is to compare exploitation level or rate of document exchange by electronic communication devices and face-to-face communication.

Use of communication technologies in document exchange for the management of construction projects

Science.gov (United States)

Mesároš, Peter; Mandičák, Tomáš

2016-06-01

Information and communication technologies represent a set of people, processes, technical and software tools providing collection, transport, storage and processing of data for distribution and presentation of information. Particularly communication systems are the main tool for information exchange. Of the other part, these technologies have a broad focus and use. One of them is the exchange of documents in the management of construction projects. Paper discusses the issue of exploitation level of communication technologies in construction project management. The main objective of this paper is to analyze exploitation level of communication technologies. Another aim of the paper is to compare exploitation level or rate of document exchange by electronic communication devices and face-to-face communication.

The beneficial applications of nuclear technology: an educational project to disseminate knowledge and encourage research

Energy Technology Data Exchange (ETDEWEB)

Levy, Denise S., E-mail: denise@radioatividades.com.br [Omiccron Programacao Grafica Ltda (Omiccron P.G.), Atibaia, SP (Brazil)

2013-07-01

Nuclear technology is part of our everyday life and helps to improve the quality of our lifestyle in more ways than people realize. Nevertheless, the issue divides public opinion in Brazil and worldwide. There is still great misinformation about nuclear technology and peaceful uses of radiation. Most often, the media and social networks associate radiation to nuclear weapons or major accidents. Parents and teachers are often unaware of the matter. Any construction depends on a solid foundation and education is the foundation of every society. This project aims the dissemination of nuclear technology contents for teachers and students of Elementary and Secondary Education throughout Brazil. Whereas Internet access has increased strongly in Brazilian schools, this project provides various web-based short courses about nuclear technology and its beneficial applications in several areas, such as medicine, agriculture, industry and energy. The design, created according to modern concepts, presents different thematic roles which please children and youth. Since this project aims the dissemination of information, all courses are offered to the public at absolutely no cost. Still, the Project will provide a restricted area for teachers, with related material to develop in class. This educational project uses the combination of multiple technologies and last generation internet resources. All content can be accessed from any traditional internet connection, either for computers or mobile technologies. Our goal is to promote the benefits of nuclear technology for new generations, combating misinformation, omission of the media and knowledge fragmentation. Education transforms old prejudices and inspires new thoughts, stimulating development and encouraging scientific and technological research. (author)

The beneficial applications of nuclear technology: an educational project to disseminate knowledge and encourage research

International Nuclear Information System (INIS)

Levy, Denise S.

2013-01-01

Nuclear technology is part of our everyday life and helps to improve the quality of our lifestyle in more ways than people realize. Nevertheless, the issue divides public opinion in Brazil and worldwide. There is still great misinformation about nuclear technology and peaceful uses of radiation. Most often, the media and social networks associate radiation to nuclear weapons or major accidents. Parents and teachers are often unaware of the matter. Any construction depends on a solid foundation and education is the foundation of every society. This project aims the dissemination of nuclear technology contents for teachers and students of Elementary and Secondary Education throughout Brazil. Whereas Internet access has increased strongly in Brazilian schools, this project provides various web-based short courses about nuclear technology and its beneficial applications in several areas, such as medicine, agriculture, industry and energy. The design, created according to modern concepts, presents different thematic roles which please children and youth. Since this project aims the dissemination of information, all courses are offered to the public at absolutely no cost. Still, the Project will provide a restricted area for teachers, with related material to develop in class. This educational project uses the combination of multiple technologies and last generation internet resources. All content can be accessed from any traditional internet connection, either for computers or mobile technologies. Our goal is to promote the benefits of nuclear technology for new generations, combating misinformation, omission of the media and knowledge fragmentation. Education transforms old prejudices and inspires new thoughts, stimulating development and encouraging scientific and technological research. (author)

Technology transfer by CDM projects: A comparison of Brazil, China, India and Mexico

International Nuclear Information System (INIS)

Dechezlepretre, Antoine; Glachant, Matthieu; Meniere, Yann

2009-01-01

In a companion paper [Dechezlepretre, A., Glachant, M., Meniere, Y., 2008. The Clean Development Mechanism and the international diffusion of technologies: An empirical study, Energy Policy 36, 1273-1283], we gave a general description of technology transfers by Clean Development Mechanism (CDM) projects and we analyzed their drivers. In this paper, we use the same data and similar econometric models to explain inter-country differences. We focus on 4 countries gathering about 75% of the CDM projects: Brazil, China, India and Mexico. Sixty eight percent of Mexican projects include an international transfer of technology. The rates are, respectively, 12%, 40% and 59% for India, Brazil and China. Our results show that transfers to Mexico and Brazil are mainly related to the strong involvement of foreign partners and good technological capabilities. Besides a relative advantage with respect to these factors, the higher rate of international transfers in Mexico seems to be due to a sector-composition effect. The involvement of foreign partners is less frequent in India and China, where investment opportunities generated by fast growing economies seem to play a more important role in facilitating international technology transfers through the CDM. International transfers are also related to strong technology capabilities in China. In contrast, the lower rate of international transfer (12%) in India may be due to a better capability to diffuse domestic technologies

75 FR 60091 - Science and Technology Reinvention Laboratory Personnel Management Demonstration Project...

Science.gov (United States)

2010-09-29

... DEPARTMENT OF DEFENSE Office of the Secretary Science and Technology Reinvention Laboratory Personnel Management Demonstration Project, Department of the Army, Army Research, Development and... project; correction. SUMMARY: On September 9, 2010 (75 FR 55199), DoD published a notice concerning the...

THE APPLICATION OF FORESIGHT PROJECTS IN FORMATION OF TECHNOLOGICAL COMPANIES’ INNOVATION DEVELOPMENT STRATEGY

Directory of Open Access Journals (Sweden)

M. E. Zolotareva

2016-01-01

Full Text Available In the article is considered the possibility of application of methodology of foresight to the formation of strategy of innovative development of technological companies. The application of existing approaches to defining targets and goals of innovation development does not meet the requirements of the nonlinearity of the modern processes of technological companies’ innovation development.The goals and objectives. The purpose of this article is to study the possibilities of application of methods of foresight in forming of technological companies’ innovation development strategy. To achieve the goal, the author has solved the following problems: considered the interrelationship and interdependence between corporate strategy and technological companies’ innovation development strategy; defined the main problems of formation technological companies’ innovation development strategies; revealed the concept of "foresight" and diff erence in methodology of foresight and traditional forecasting techniques; defined the basic principles of foresight; presents the main stages of the foresight project implementation in technological companies.Research methods. The theoretical basis of the study are the publications of Russian and foreign scientists in the field of formation and development of innovation strategies through the application of foresight methods at the level of national innovation system and at company level. As a methodological basis of the study used methods of analysis, synthesis, induction method, deduction method, the comparison, was applied certain aspects of the synergetic analysis.Summary. The results of Russian and foreign researchers systematized by author confirm the possibility and necessity foresight projects implementation in formation and adjustment of technological companies’ innovation development strategies and in the national innovation system development. The principles of engagement of various social forces

Long-Term Potentiation in the Motor Cortex

Science.gov (United States)

Iriki, Atsushi; Pavlides, Constantine; Keller, Asaf; Asanuma, Hiroshi

1989-09-01

Long-term potentiation (LTP) is a model for learning and memory processes. Tetanic stimulation of the sensory cortex produces LTP in motor cortical neurons, whereas tetanization of the ventrolateral nucleus of the thalamus, which also projects to the motor cortex, does not. However, after simultaneous high-frequency stimulation of both the sensory cortex and the ventrolateral nucleus of the thalamus, LTP of thalamic input to motor cortical neurons is induced. This associative LTP occurs only in neurons in the superficial layers of the motor cortex that receive monosynaptic input from both the sensory cortex and the ventrolateral nucleus of the thalamus. Associative LTP in the motor cortex may constitute a basis for the retention of motor skills.

FEATURES OF THE PROJECT-ORIENTED MANAGEMENT OF HIGH-TECHNOLOGY ENTERPRISES

Directory of Open Access Journals (Sweden)

E. D. Dobrova

2016-01-01

Full Text Available This article is explored the concept of "project portfolio", defined the role and place of project portfolio management in the overall enterprise management structure, the formation of the project portfolio and its limitations. The aim of the article is to study the role and place of project management in the overall enterprise management system, and the relationship of the management processes at diff erent organizational levels.The formation of the strategic projects portfolio of the company – it is an urgent task which is associated with the strengthening of innovation and investment activity of the operating in Russia enterprises. Nowadays, transfer of enterprises activities to an innovative way of development is going on in the face of the deteriorating international situation, Russia's isolation from European countries and the United States, and the implementation of the sanctions policy, changes in the domestic economic and political course. These circumstances, of course, could not aff ect the adjustment of activities and strategic goals of the development of enterprises, at the level of their financial and economic stability. At the same time, the growth of innovation activity in a number of sectors, particularly in high-technology industries, it creates the need for the formation of the project portfolio, which allows to achieve the strategic objectives of enterprises and enhance their competitiveness.During the preparation of the article there were identified a core set of problems faced by the enterprises during the transition to a model of the project management, which is due, primarily, poor project management technologies in Russia, and it is complicated by the lack of a clear definition of objectives and vision benefits for enterprises. In addition, the reasons for the backlog are caused by the low level of project management maturity of the enterprise, which is caused by a lack of personnel with expertise in this field of

105-C Reactor interim safe storage project technology integration plan

International Nuclear Information System (INIS)

Pulsford, S.K.

1997-01-01

The 105-C Reactor Interim Safe Storage Project Technology Integration Plan involves the decontamination, dismantlement, and interim safe storage of a surplus production reactor. A major goal is to identify and demonstrate new and innovative D and D technologies that will reduce costs, shorten schedules, enhance safety, and have the potential for general use across the RL complex. Innovative technologies are to be demonstrated in the following areas: Characterization; Decontamination; Waste Disposition; Dismantlement, Segmentation, and Demolition; Facility Stabilization; and Health and Safety. The evaluation and ranking of innovative technologies has been completed. Demonstrations will be selected from the ranked technologies according to priority. The contractor team members will review and evaluate the demonstration performances and make final recommendations to DOE

Expedited technology demonstration project (Revised mixed waste management facility project) Project baseline revision 4.0 and FY98 plan

International Nuclear Information System (INIS)

Adamson, M. G.

1997-01-01

The re-baseline of the Expedited Technology Demonstration Project (Revised Mixed Waste Facility Project) is designated as Project Baseline Revision 4.0. The last approved baseline was identified as Project Baseline Revision 3.0 and was issued in October 1996. Project Baseline Revision 4.0 does not depart from the formal DOE guidance followed by, and contained in, Revision 3.0. This revised baseline document describes the MSO and Final Forms testing activities that will occur during FY98, the final year of the ETD Project. The cost estimate for work during FY98 continues to be $2.OM as published in Revision 3.0. However, the funds will be all CENRTC rather than the OPEX/CENTRC split previously anticipated. LLNL has waived overhead charges on ETD Project CENRTC funds since the beginning of project activities. By requesting the $2.OM as all CENTRC a more aggressive approach to staffing and testing can be taken. Due to a cost under- run condition during FY97 procurements were made and work was accomplished, with the knowledge of DOE, in the Feed Preparation and Final Forms areas that were not in the scope of Revision 3.0. Feed preparation activities for FY98 have been expanded to include the drum opening station/enclosure previously deleted

Flexible Electrostatic Technology for Capture and Handling Project

Science.gov (United States)

Keys, Andrew; Bryan, Tom; Horwitz, Chris; Rakoczy, John; Waggoner, Jason

2015-01-01

previous MSFC and NASA proposals or concepts can now be realized or simplified by the development of the this initial and future FETCH grippers including commercial resupply, Exploration vehicle assembly, Satellite servicing, and orbital debris removal since a major part of these missions is to align to and capture some handle. Completed Project (2013 - 2014) Flexible Electrostatic Technology for Capture & Handling Project Center Innovation Fund: MSFC CIF Program | Space Technology Mission Directorate (STMD) For more information visit techport.nasa.gov Some NASA technology projects are smaller (for example SBIR/STTR, NIAC and Center Innovation Fund), and will have less content than other, larger projects. Newly created projects may not sensors or injection of permanent adhesives. With gripping forces estimated between 0.5 and 2.5 pounds per square inch or 70-300 lb./sq. ft. of surface contact, the FETCH can turn-on and turn-off rapidly and repeatedly to enable sample handling, soft docking, in-space assembly, and precision relocation for accurate anchor adhesion.

Ceramics Technology Project database: September 1991 summary report

Energy Technology Data Exchange (ETDEWEB)

Keyes, B.L.P.

1992-06-01

The piston ring-cylinder liner area of the internal combustion engine must withstand very-high-temperature gradients, highly-corrosive environments, and constant friction. Improving the efficiency in the engine requires ring and cylinder liner materials that can survive this abusive environment and lubricants that resist decomposition at elevated temperatures. Wear and friction tests have been done on many material combinations in environments similar to actual use to find the right materials for the situation. This report covers tribology information produced from 1986 through July 1991 by Battelle columbus Laboratories, Caterpillar Inc., and Cummins Engine Company, Inc. for the Ceramic Technology Project (CTP). All data in this report were taken from the project`s semiannual and bimonthly progress reports and cover base materials, coatings, and lubricants. The data, including test rig descriptions and material characterizations, are stored in the CTP database and are available to all project participants on request. Objective of this report is to make available the test results from these studies, but not to draw conclusions from these data.

Project inspection using mobile technology - phase I : an investigation into existing business processes and areas for improvement using mobile technology.

Science.gov (United States)

2013-08-01

As mobile technology becomes widely available and affordable, transportation agencies can use this technology to : streamline operations involved within project inspection. This research, conducted in two phases, identified : opportunities for proces...

Technology and commercial supply of components for the LHC project

CERN Document Server

Faugeras, Paul E

1998-01-01

After a brief reminder of the motives and the outline of the Large Hadron Collider (LHC) project, one will review the technology and the hardware to be built up. The LHC calls for High Tech innovation s in superconductivity, cryogenics with superfluid helium, ultra high vacuum, surface treatments, etc. which have to be transferred to Industry and produced on a large scale. It will also make extensi ve use of more conventional technology, but because of the intrinsic complexity of the machine and of the international nature of its funding and procurement sources, it will require sophisticated man agement and logistics tools to minimize costs and installation time. The planning for the whole project will be given with an indication of the nature and time schedule of the major contracts.

Collaborative Visualization Project: shared-technology learning environments for science learning

Science.gov (United States)

Pea, Roy D.; Gomez, Louis M.

1993-01-01

Project-enhanced science learning (PESL) provides students with opportunities for `cognitive apprenticeships' in authentic scientific inquiry using computers for data-collection and analysis. Student teams work on projects with teacher guidance to develop and apply their understanding of science concepts and skills. We are applying advanced computing and communications technologies to augment and transform PESL at-a-distance (beyond the boundaries of the individual school), which is limited today to asynchronous, text-only networking and unsuitable for collaborative science learning involving shared access to multimedia resources such as data, graphs, tables, pictures, and audio-video communication. Our work creates user technology (a Collaborative Science Workbench providing PESL design support and shared synchronous document views, program, and data access; a Science Learning Resource Directory for easy access to resources including two-way video links to collaborators, mentors, museum exhibits, media-rich resources such as scientific visualization graphics), and refine enabling technologies (audiovisual and shared-data telephony, networking) for this PESL niche. We characterize participation scenarios for using these resources and we discuss national networked access to science education expertise.

Present status of some technological activities supporting the MOLCARE project

Energy Technology Data Exchange (ETDEWEB)

Torazza, A. [Ansaldo Ricerche S.r.l., Genova (Italy); Rocchini, G. [ENEL, Milano (Italy); Scagliotti, M. [CISE, Milano (Italy)

1996-12-31

The development of MCFC stack technology is carried out at Ansaldo Ricerche in the framework of the MOLCARE project, a cooperation with Spanish companies under a partial UE funding, while a specific research program concerning the physico-chemical characterization of materials is performed jointly by CISE and ENEL. The project includes the development, the construction and the testing of a full scale 100 kW prototype, the assessment of stack technology on subscale stacks, the mathematical modelling of the MCFC based plants and the basic researches. The aim of the basic researches, carried out on single cells, is to improve the effectiveness and durability of both the active and the hardware materials. The Ansaldo stack technology is based on external manifolding. The full scale 100 kW prototype will be integrated with the sensible heat reformer and other ancillary equipments according to the {open_quote}Compact Unit (CU){close_quotes} concept. These technical choices stress requirements for manifold gasket configuration. electrolyte migration control, {Delta}p management and porous component compaction.

NASA Remediation Technology Collaboration Development Task, Overview and Project Summaries

Science.gov (United States)

Romeo, James G.

2014-01-01

An overview presentation of NASA's Remediation Technology Collaboration Development Task including the following project summaries: in situ groundwater monitor, in situ chemical oxidation, in situ bioremediation, horizontal multi-port well, and high resolution site characterization.

CO2 Capture Project-An Integrated, Collaborative Technology Development Project for Next Generation CO2 Separation, Capture and Geologic Sequestration

Energy Technology Data Exchange (ETDEWEB)

Helen Kerr; Linda M. Curran

2005-04-15

The CO{sub 2} Capture Project (CCP) was a joint industry project, funded by eight energy companies (BP, ChevronTexaco, EnCana, ENI, Norsk Hydro, Shell, Statoil, and Suncor) and three government agencies (European Union [DG RES & DG TREN], the Norwegian Research Council [Klimatek Program] and the U.S. Department of Energy [NETL]). The project objective was to develop new technologies that could reduce the cost of CO{sub 2} capture and geologic storage by 50% for retrofit to existing plants and 75% for new-build plants. Technologies were to be developed to ''proof of concept'' stage by the end of 2003. Certain promising technology areas were increased in scope and the studies extended through 2004. The project budget was approximately $26.4 million over 4 years and the work program is divided into eight major activity areas: Baseline Design and Cost Estimation--defined the uncontrolled emissions from each facility and estimate the cost of abatement in $/tonne CO{sub 2}. Capture Technology, Post Combustion: technologies, which can remove CO{sub 2} from exhaust gases after combustion. Capture Technology, Oxyfuel: where oxygen is separated from the air and then burned with hydrocarbons to produce an exhaust with high CO{sub 2} for storage. Capture Technology, Pre-Combustion: in which, natural gas and petroleum cokes are converted to hydrogen and CO{sub 2} in a reformer/gasifier. Common Economic Model/Technology Screening: analysis and evaluation of each technology applied to the scenarios to provide meaningful and consistent comparison. New Technology Cost Estimation: on a consistent basis with the baseline above, to demonstrate cost reductions. Geologic Storage, Monitoring and Verification (SMV): providing assurance that CO{sub 2} can be safely stored in geologic formations over the long term. Non-Technical: project management, communication of results and a review of current policies and incentives governing CO{sub 2} capture and storage. Pre

Measuring Student Career Interest within the Context of Technology-Enhanced STEM Projects: A Cross-Project Comparison Study Based on the Career Interest Questionnaire

Science.gov (United States)

Peterman, Karen; Kermish-Allen, Ruth; Knezek, Gerald; Christensen, Rhonda; Tyler-Wood, Tandra

2016-12-01

This article describes Energy for ME and Going Green! Middle Schoolers Out to Save the World, two Science, Technology, Engineering, and Mathematics (STEM) education programs with the common goal of improving students' attitudes about scientific careers. The authors represent two project teams, each with funding from the National Science Foundation's ITEST program. Using different approaches and technology, both projects challenged students to use electricity monitoring system data to create action plans for conserving energy in their homes and communities. The impact of each project on students' career interests was assessed via a multi-method evaluation that included the Career Interest Questionnaire (CIQ), a measure that was validated within the context of ITEST projects and has since become one of the instruments used most commonly across the ITEST community. This article explores the extent to which the CIQ can be used to document the effects of technology-enhanced STEM educational experiences on students' career attitudes and intentions in different environments. The results indicate that the CIQ, and the Intent subscale in particular, served as significant predictors of students' self-reported STEM career aspirations across project context. Results from each project also demonstrated content gains by students and demonstrated the impact of project participation and gender on student outcomes. The authors conclude that the CIQ is a useful tool for providing empirical evidence to document the impact of technology-enhanced science education programs, particularly with regard to Intent to purse a STEM career. The need for additional cross-project comparison studies is also discussed.

A Project in Support of Nuclear Technology Cooperation

Energy Technology Data Exchange (ETDEWEB)

Ko, Young Cheol; Kim, Kyoung Pyo; Yi, Ji Ho [and others

2007-12-15

The results and contents of the project are as follows; - Establish strategies of international cooperation in an effort to promote our nation's Leading role in international society, to form the foundation for the effective transfer of nuclear technology to developing countries, and to cope with the rapidly changing international nuclear climate. - Domestic INIS project has carried out various activities on supporting a decision-making for INIS Secretariat, exchanges of the statistical information between INIS and the country, and technical assistance for domestic end-users using INIS database. - Based on the construction of INIS database sent by member states, the data published in the country has been gathered, collected, and inputted to INIS database according to the INIS reference series. - Using the INIS output data, it has provided domestic users with searching INIS CD-ROM DB and INIS online database, INIS SDI service, non-conventional literature delivery services and announce INIS to users. - Establish the integrated management system of information resources and to automate business flow and to improve business productivity through efficient information sharing. - Promotion of domestic nuclear energy technology by utilizing nuclear energy information and computer software developed in the advanced countries.

A Project in Support of Nuclear Technology Cooperation

International Nuclear Information System (INIS)

Ko, Young Cheol; Kim, Kyoung Pyo; Yi, Ji Ho

2007-12-01

The results and contents of the project are as follows; - Establish strategies of international cooperation in an effort to promote our nation's Leading role in international society, to form the foundation for the effective transfer of nuclear technology to developing countries, and to cope with the rapidly changing international nuclear climate. - Domestic INIS project has carried out various activities on supporting a decision-making for INIS Secretariat, exchanges of the statistical information between INIS and the country, and technical assistance for domestic end-users using INIS database. - Based on the construction of INIS database sent by member states, the data published in the country has been gathered, collected, and inputted to INIS database according to the INIS reference series. - Using the INIS output data, it has provided domestic users with searching INIS CD-ROM DB and INIS online database, INIS SDI service, non-conventional literature delivery services and announce INIS to users. - Establish the integrated management system of information resources and to automate business flow and to improve business productivity through efficient information sharing. - Promotion of domestic nuclear energy technology by utilizing nuclear energy information and computer software developed in the advanced countries

A Project in Support of Nuclear Technology Cooperation

Energy Technology Data Exchange (ETDEWEB)

Ko, Young Cheol; Kim, Kyoung Pyo; Yi, Ji Ho (and others)

2007-12-15

The results and contents of the project are as follows; - Establish strategies of international cooperation in an effort to promote our nation's Leading role in international society, to form the foundation for the effective transfer of nuclear technology to developing countries, and to cope with the rapidly changing international nuclear climate. - Domestic INIS project has carried out various activities on supporting a decision-making for INIS Secretariat, exchanges of the statistical information between INIS and the country, and technical assistance for domestic end-users using INIS database. - Based on the construction of INIS database sent by member states, the data published in the country has been gathered, collected, and inputted to INIS database according to the INIS reference series. - Using the INIS output data, it has provided domestic users with searching INIS CD-ROM DB and INIS online database, INIS SDI service, non-conventional literature delivery services and announce INIS to users. - Establish the integrated management system of information resources and to automate business flow and to improve business productivity through efficient information sharing. - Promotion of domestic nuclear energy technology by utilizing nuclear energy information and computer software developed in the advanced countries.

Laboratory technology research: Abstracts of FY 1998 projects

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-11-01

The Laboratory Technology Research (LTR) program supports high-risk, multidisciplinary research partnerships to investigate challenging scientific problems whose solutions have promising commercial potential. These partnerships capitalize on two great strengths of the country: the world-class basic research capability of the DOE Office of Science (SC) national laboratories and the unparalleled entrepreneurial spirit of American industry. Projects supported by the LTR program in FY 1998 explore the applications of basic research advances relevant to DOE`s mission over a full range of scientific disciplines. The program presently emphasizes three critical areas of mission-related research: advanced materials, intelligent processing and manufacturing research, and environmental and biomedical research. Abstracts for 85 projects are contained in this report.

Information technology project risk management in Peru

OpenAIRE

Del Carpio Gallegos, Javier

2014-01-01

This article shows how some principles, uses, and practices of risk management are applied in information technology projects in Peru; in the last four years, in representative sectors like manufacturing, banking, information and communications, academics institutions, construction, government, consulting, services, and others. El presente artículo muestra algunos principios, usos y prácticas de cómo la gestión de riesgos de proyectos de tecnología se ha llevado a cabo en los últimos cuatr...

BIM integration in education: A case study of the construction technology project Bolt Tower Dolni Vitkovice

Directory of Open Access Journals (Sweden)

Venkrbec Vaclav

2017-12-01

Full Text Available Building information modeling (BIM can support effectiveness during many activities in the AEC industry. even when processing a construction-technological project. This paper presents an approach how to use building information model in higher education, especially during the work on diploma thesis and it supervision. Diploma thesis is project based work, which aims to compile a construction-technological project for a selected construction. The paper describes the use of input data, working with them and compares this process with standard input data such as printed design documentation. The effectiveness of using the building information model as a input data for construction-technological project is described in the conclusion.

BIM integration in education: A case study of the construction technology project Bolt Tower Dolni Vitkovice

Science.gov (United States)

Venkrbec, Vaclav; Bittnerova, Lucie

2017-12-01

Building information modeling (BIM) can support effectiveness during many activities in the AEC industry. even when processing a construction-technological project. This paper presents an approach how to use building information model in higher education, especially during the work on diploma thesis and it supervision. Diploma thesis is project based work, which aims to compile a construction-technological project for a selected construction. The paper describes the use of input data, working with them and compares this process with standard input data such as printed design documentation. The effectiveness of using the building information model as a input data for construction-technological project is described in the conclusion.

[Problem based learning by distance education and analysis of a training system].

Science.gov (United States)

Dury, Cécile

2004-12-01

This article presents and analyses a training system aiming at acquiring skills in nursing cares. The aims followed are the development: --of an active pedagogic method: learning through problems (LTP); --of the interdisciplinary and intercultural approach, the same problems being solves by students from different disciplines and cultures; --of the use of the new technologies of information and communication (NTIC) so as to enable a maximal "distance" cooperation between the various partners of the project. The analysis of the system shows that the pedagogic aims followed by LTP are reached. The pluridisciplinary and pluricultural approach, to be optimal, requires great coordination between the partners, balance between the groups of students from different countries and disciplines, training and support from the tutors in the use of the distance teaching platform.

Applications and Prospects of Modularization Technology in HTR Project Starting from Primary Loop Cavity Construction

International Nuclear Information System (INIS)

Yang Guokang; Chen Jing; Huang Wen; Lin Lizhi; Sun Yunlun; Chen Yan; Mao Jiaxin; Wang Yougang; Wang Jinwen; Lin Mingfeng; Yang Mingshan

2014-01-01

Primary loop cavity is one of the key areas and major difficulties in HTR-PM project construction. In order to shorten the construction schedule and improve the construction quality, researches on modular design and construction of primary loop cavity has been carried out and the results have been applied in HTR-PM project construction, and got significant application benefit. This paper summarizes the modularization technology application research and project implementation results of primary loop cavity, and analyzes the application and prospects of modularization technology in the HTR project construction. (author)

Experience in Use of Project Method during Technology Lessons in Secondary Schools of the USA

Science.gov (United States)

Sheludko, Inna

2015-01-01

The article examines the opportunities and prospects for the use of experience of project method during "technology lessons" in US secondary schools, since the value of project technology implementation experience into the educational process in the USA for ensuring holistic development of children, preparing them for adult life, in…

E-Learning and the Use of New Technologies in the "Kolumbus-Kids" Project in Germany

Science.gov (United States)

Wegner, Claas; Homann, Wiebke; Strehlke, Friederike; Borgmann, Annika

2014-01-01

This article presents the science project "Kolumbus-Kids" as an example of the innovative use of "E-Learning" and other "new technologies" to advance student learning and new-media education. The project benefits from various technology-based education strategies and E-Learning scenarios which are employed during the…

EUROPEAN PROJECTS AS A TOOL FOR IMPROVING FARMERS SKILLS VIA MODERN INFORMATION TECHNOLOGIES

Directory of Open Access Journals (Sweden)

Zuzana PALKOVA

2013-01-01

Full Text Available This article presents European projects with the main focus on the improving the skills and competitiveness of farmers by modern information and communication technologies and e-learning methods. Two projects – AVARES - Enhance attractiveness of renewable energy training by virtual reality and NewCAP - New European Standards in the Context of Reformed EU Common Agricultural Policy are projects under the Leonardo da Vinci Transfer ofInnovation grant scheme. They try to present new way of vocational education and training in the agrosector. The main aim of the AVARES project is to develop the multimedia learning materials for vocational education and training in the field of agricultural and rural development and application of modern information and communication technologies into vocational education and training. The emphasis is put on the application of modern ICT equipment and technologies, with the main focus on the Virtual reality, 3D visual display and e - learning 2.0 methods. New programming period 2014 – 2020 will bring significant changes within the Common Agricultural Policy (CAP which will have a serious impact on economy especially of larger beneficiaries. The „NewCAP“ project aiming at preparation of actors in rural areas to take the proposed changes in the policy through interactive educational programme.

Hypersonic Technology Developments with EU Co-Funded Projects

Science.gov (United States)

2010-09-01

and Hypersonic Systems and Technologies Conference, AIAA-2006-8109, 06-09/11 2006, Canberra, Australia. [18] Karl S., Hannemann K., Steelant J. and...Canberra, Australia. [23] Haidn, O., Ciezki, H., Hannemann , K. and Karl., S., Selected Supersonic Combustion Activities at DLR within the European...LAPCAT Project, 2nd European Conference for Aerospace Sciences (EUCASS), July 2007, Brussels, Belgium. [24] Martinez-Schram J. , Karl S., Hannemann K

UPDATING THE BASIC PRINCIPLES OF PROJECT EDUCATION TECHNOLOGY IN FUTURE MUSIC TEACHERS’ VOCAL AND CHORAL TRAINING

Directory of Open Access Journals (Sweden)

Liang Haiye

2017-04-01

Full Text Available The article is devoted to characterizing features of implementing project technology into future music teachers’ vocal and choral training. The analysis of scientific papers of outstanding scientists in philosophy, psychology, and art education, which deal with modern directions of using project technology, highlight its role in art education process. A methodological base is supported by considering contemporary scientific researches, in particular the theory and methodology of musical studies in accordance with forming students’ independence in the process of solving educational problems by means of project technology; developing principles of students’ professional training optimization on the basis of project activity; innovative development of future music teachers’ professional training that gives to the presented material novelty and presentable appearance. Studying future music teachers’ vocal and choral training as a process of constructing that has a special purpose of improving the quality descriptions of educational vocal and choral collective sound functioning, the author of the article discloses the basic principles of implementing project technology into future music teachers’ vocal and choral training. The author of the article pays the special attention to revealing specific features and maintenance of project technology in vocal and choral training of future leaders of child's art groups. An emphasis is made on the following basic factors that influence development of students’ creative individuality: constructing projects of their own becoming; setting aims, tasks, strategies and facilities of vocal and choral work; directing to the result; independent creative activity; presentation, reflection and correction of a project. On the basis of the obtained data the following principles of project technology are put forward in future music teachers’ vocal and choral training: principle of independence; principle of

Projects at the Western Environmental Technology Office. Quarterly technical progress report, April 1--June 30, 1995

International Nuclear Information System (INIS)

1995-01-01

This report contains brief outlines of the multiple projects under the responsibility of the Western Environmental Technology Office in Butte Montana. These projects include biomass remediation, remediation of contaminated soils, mine waste technology, and several other types of remediation

Overview and Summary of the Advanced Mirror Technology Development Project

Science.gov (United States)

Stahl, H. P.

2014-01-01

Advanced Mirror Technology Development (AMTD) is a NASA Strategic Astrophysics Technology project to mature to TRL-6 the critical technologies needed to produce 4-m or larger flight-qualified UVOIR mirrors by 2018 so that a viable mission can be considered by the 2020 Decadal Review. The developed mirror technology must enable missions capable of both general astrophysics & ultra-high contrast observations of exoplanets. Just as JWST’s architecture was driven by launch vehicle, a future UVOIR mission’s architectures (monolithic, segmented or interferometric) will depend on capacities of future launch vehicles (and budget). Since we cannot predict the future, we must prepare for all potential futures. Therefore, to provide the science community with options, we are pursuing multiple technology paths. AMTD uses a science-driven systems engineering approach. We derived engineering specifications for potential future monolithic or segmented space telescopes based on science needs and implement constraints. And we are maturing six inter-linked critical technologies to enable potential future large aperture UVOIR space telescope: 1) Large-Aperture, Low Areal Density, High Stiffness Mirrors, 2) Support Systems, 3) Mid/High Spatial Frequency Figure Error, 4) Segment Edges, 5) Segment-to-Segment Gap Phasing, and 6) Integrated Model Validation Science Advisory Team and a Systems Engineering Team. We are maturing all six technologies simultaneously because all are required to make a primary mirror assembly (PMA); and, it is the PMA’s on-orbit performance which determines science return. PMA stiffness depends on substrate and support stiffness. Ability to cost-effectively eliminate mid/high spatial figure errors and polishing edges depends on substrate stiffness. On-orbit thermal and mechanical performance depends on substrate stiffness, the coefficient of thermal expansion (CTE) and thermal mass. And, segment-to-segment phasing depends on substrate & structure stiffness

Internal evaluation of the European network for health technology assessment project.

Science.gov (United States)

Håheim, Lise Lund; Imaz, Iñaki; Loud, Marlène Läubli; Gasparetto, Teresa; González-Enriquez, Jesús; Dahlgren, Helena; Trofimovs, Igor; Berti, Elena; Mørland, Berit

2009-12-01

The internal evaluation studied the development of the European network for Health Technology Assessment (EUnetHTA) Project in achieving the general objective of establishing an effective and a sustainable network of health technology assessment (HTA) in Europe. The Work Package 3 group was dedicated to this task and performed the work. Information on activities during the project was collected from three sources. First, three yearly cross-sectional studies surveyed the participants' opinions. Responses were by individuals or by institutions. The last round included surveys to the Steering Committee, the Stakeholder Forum, and the Secretariat. Second, the Work Package Lead Partners were interviewed bi-annually, five times in total, to update the information on the Project's progress. Third, additional information was sought in available documents. The organizational structure remained stable. The Project succeeded in developing tools aimed at providing common methodology with intent to establish a standard of conducting and reporting HTA and to facilitate greater collaboration among agencies. The participants/agencies expressed their belief in a network and in maintaining local/national autonomy. The Work Package Leaders expressed a strong belief in the solid base of the Project for a future network on which to build, but were aware of the need for funding and governmental support. Participants and Work Package Leaders have expressed support for a future network that will improve national and international collaboration in HTA based on the experience from the EUnetHTA project.

Report: EPA Needs to Improve Oversight of Its Information Technology Projects

Science.gov (United States)

Report #2005-P-00023, September 14, 2005. EPA’s Office of Environmental Information (OEI) did not sufficiently oversee information technology projects to ensure they met planned budgets and schedules.

Laboratory Technology Research: Abstracts of FY 1996 projects

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-12-31

The Laboratory Technology Research (LTR) program supports high-risk, multidisciplinary research partnerships to investigate challenging scientific problems whose solutions have promising commercial potential. These partnerships capitalize on two great strengths of this country: the world-class basic research capability of the DOE Energy Research (ER) multi-program national laboratories and the unparalleled entrepreneurial spirit of American industry. Projects supported by the LTR program are conducted by the five ER multi-program laboratories: Argonne, Brookhaven, Lawrence Berkeley, Oak Ridge, and Pacific Northwest National Laboratories. These projects explore the applications of basic research advances relevant to Department of Energy`s (DOE) mission over a full range of scientific disciplines. The program presently emphasizes three critical areas of mission-related research: advanced materials, intelligent processing/manufacturing research, and sustainable environments.

Small Hydropower Research and Development Technology Project

Energy Technology Data Exchange (ETDEWEB)

Blackmore, Mo [Near Space Systems, Inc.

2013-12-06

The objective of this work was to investigate, develop, and validate the next generation of small hydroturbine generator designs that maximize the energy transfer from flowing water to electrical power generation. What resulted from this effort was the design of a new technology hydroturbine that Near Space Systems (NSS) has named the Star*Stream© Hydroturbine. Using a design that eliminates nearly all of the shortfalls of conventional hydroturbines, the Star*Stream© Hydroturbine employs a new mechanical-to-electrical energy transfer hydro design that operates without lubrication of any kind, and does not introduce foreign chemicals or particulate matter from oil or drive shaft seal degradation into the hydro ecology. In its unique configuration, the Star*Stream© Hydroturbine is nearly environmentally inert, without the negative aspects caused by interrupting the ecological continuity, i.e., disruptions to sedimentation, water quality, habitat changes, human displacement, fish migration, etc., - while it ensures dramatically reduced timeframes to project completion. While a remarkable reduction in LCOE resulting from application of the Star*Stream© Hydroturbine technology has been the core achievement of the this effort, there have been numerous technological breakthroughs from the development effort.

Planning for, and measuring, the business value of technology projects in the oil sands

Energy Technology Data Exchange (ETDEWEB)

Sayed, M. [Northern Alberta Inst. of Technology, Edmonton, AB (Canada); Burgess, A. [Telus Energy Sector Organization, Calgary, AB (Canada)

2007-07-01

This presentation discussed new communications technology options developed for oil sands industry operators. Technology options included broadband access for data, video and voice requirements, as well as new options for video, audio, and web conferencing. Recent technology options for inter-camp communications were presented, as well as new software developments for distance education, video surveillance, and data security. Various entertainment technologies for oil sands camp employees included in-room telephones, internet and gaming access, radio, television, and family web-cams. New electronic permitting equipment was described, and details of security and verification cards and tickets were provided. The economic benefits and social advantages of adopting the technologies were discussed. A research project and assessment tool designed to predict and measure the business value of information technology (IT) and communications technologies and projects was outlined. A case study of the Schlumberger heavy equipment program was used to demonstrate the assessment tool. refs., tabs., figs.

Harbin Institute of Technology collaborative base project at APS of Argonne

Science.gov (United States)

Liu, H.; Liu, L. L.

2013-05-01

In this paper, the progress of Harbin Institute of Technology (HIT) collaborative base project, which was launched at Argonne National Laboratory in 2010, will be presented. The staff and students from HIT involved in advanced technological developments, which included tomography, high energy PDF, diffraction and scattering, and inelastic scattering techniques in APS to study structures changes of minerals and materials under high pressure conditions.

A Nordic Project Project on High Speed Low Power Design in Sub-micron CMOS Technology for Mobile

DEFF Research Database (Denmark)

Olesen, Ole

1997-01-01

circuit design is based on state-of-the-art CMOS technology (0.5µm and below) including circuits operating at 2GHz. CMOS technology is chosen, since a CMOS implementation is likely to be significantly cheaper than a bipolar or a BiCMOS solution, and it offers the possibility to integrate the predominantly...... of including good off-chip components in the design by use of innovative, inexpensive package technology.To achieve a higher level of integration, the project will use a novel codesign approach to the design strategy. Rather than making specifications based on a purely architectural approach, the work uses...

An example of technological transfer to industry: the 'IMI' project

Energy Technology Data Exchange (ETDEWEB)

Stefanini, A.; Amendolia, S.R.; Annovazzi, A.; Baldelli, P.; Bigongiari, A.; Bisogni, M.G.; Catarsi, F.; Cetronio, A.; Chianella, M.; Cinti, M.N.; Delogu, P.; Fantacci, M.E.; Galimberti, D.; Gambaccini, M.; Gilardoni, C.; Iurlaro, G.; Lanzieri, C.; Meoni, M.; Novelli, M.; Pani, R.; Passuello, G.; Pellegrini, R.; Pieracci, M.; Quattrocchi, M.; Rosso, V. E-mail: valeria.rosso@pi.infn.it; Venturelli, L

2004-02-01

Several INFN Sections and Departments of Physics of Italian Universities have spent many man-years in the attempt to adapt detector and read-out technologies, originally developed in the field of High Energy Physics, to the domain of biomedical apparatuses. The research covered such areas as the exploitation of crystals for the production of monochromatic X-ray beams, the development of devices for efficient X-ray detection, the design of advanced VLSI electronics, the improvement of Position Sensitive Photomultiplier Tubes and crystals for Nuclear Medicine gamma-cameras. These studies have been integrated in the Integrated Mammographic Imaging (IMI) project, funded by the Italian Government through the law 46/82 (art.10) and is carried on by five high-technology industries in Italy, namely LABEN, CAEN, AMS, GILARDONI and POL.HI.TECH. We report on the status of this technological transfer project.

PKMζ inhibition prevents the metaplastic change induced by conditioned taste aversion on insular cortex long-term potentiation in vivo.

Science.gov (United States)

Ángeles-Durán, Sandybel; Ramos-Languren, Laura E; Escobar, Martha L

2012-01-01

The activity history of a given neuron or pathway has been suggested to influence its future responses to synaptic inputs. In particular, training in several learning tasks produces a metaplastic change, that is, a change in the ability to induce subsequent synaptic plasticity. Experimental evidence shows that the maintenance of long term memory and long-term potentiation (LTP) requires the persistent action of the atypical protein kinase Cisoform, protein kinase M ζ (PKM ζ ). Recent work has demonstrated that the inactivation of PKM ζ in the insular cortex (IC) abolishes conditioned taste aversion (CTA) long term memory. Our previous studies in the IC have demonstrated that the induction of LTP in the basolateral amygdaloid nucleus (Bla)-IC projection previous to CTA training enhances the retention of this task. Moreover, recently, we have observed that CTA training blocks the subsequent induction of LTP in the Bla-IC projection. The aim of the present study was to investigate the participation of PKM ζon the CTA-dependent modification of the ability to induce subsequent LTP in the Bla-IC projection in vivo . Thus, we have delivered high-frequency stimulation in the Bla-IC projection in order to induce in vivo IC-LTP in the rats that underwent or did not have an impairment of CTA retention due to the intracortical administration of the selective PKM ζ pseudosubstrate inhibitory peptide, ZIP. Our results show that the microinfusion of ZIP into the IC of the behaving rats impairs long-term memory of CTA and prevents its effects on IC-LTP. These results indicate that PKM ζ is a key component of the cellular mechanisms necessary for the persistence of lasting memory traces as well as for those underlying metaplastic changes in neocortex, contributing to the persistence of aversive memories.

Ubiquitous Learning Project Using Life-Logging Technology in Japan

Science.gov (United States)

Ogata, Hiroaki; Hou, Bin; Li, Mengmeng; Uosaki, Noriko; Mouri, Kosuke; Liu, Songran

2014-01-01

A Ubiquitous Learning Log (ULL) is defined as a digital record of what a learner has learned in daily life using ubiquitous computing technologies. In this paper, a project which developed a system called SCROLL (System for Capturing and Reusing Of Learning Log) is presented. The aim of developing SCROLL is to help learners record, organize,…

Using technology-enhanced, cooperative, group-project learning for student comprehension and academic performance

Science.gov (United States)

Tlhoaele, Malefyane; Suhre, Cor; Hofman, Adriaan

2016-05-01

Cooperative learning may improve students' motivation, understanding of course concepts, and academic performance. This study therefore enhanced a cooperative, group-project learning technique with technology resources to determine whether doing so improved students' deep learning and performance. A sample of 118 engineering students, randomly divided into two groups, participated in this study and provided data through questionnaires issued before and after the experiment. The results, obtained through analyses of variance and structural equation modelling, reveal that technology-enhanced, cooperative, group-project learning improves students' comprehension and academic performance.

Harnessing the Power of Technologies to Manage Collaborative e-Learning Projects in Dispersed Environments

Science.gov (United States)

Gosper, Maree Veroncia; McNeill, Margot Anne; Woo, Karen

2010-01-01

"The impact of web-based lecture technologies on current and future practice in learning and teaching" was a collaborative project across four Australian universities, funded by the Australian Learning and Teaching Council (ALTC). The project was both exploratory and developmental in nature and according to the project's external…

Technology choice and CDM projects in China: case study of a small steel company in Shandong Province

International Nuclear Information System (INIS)

Kaneko, Shinji; Yonamine, Asaka; Jung, Tae Yong

2006-01-01

Corporate motives and strategies of both investing and hosting country affect the outcomes of a clean development mechanism (CDM) project-who introduces what technology to whom-and result in large differences in economic viability and the CO 2 emission reductions. This is particularly true for steel industry in which steel making consists of many detailed and complex processes, a given strategy could produce cumulative effects of the individual technologies used, leading to large energy savings overall. The objective of this study is to demonstrate some analytical methods that can be used to quantitatively evaluate the impacts of technology selection on the profit performance of CDM projects. Specifically, in this study we analyze a CDM project to introduce energy saving technology from Japan to a small steel manufacturer in China's Shandong Province, and conduct a simulation of the quantitative relationships between various technology options and profitability. Based on these results, we examine the environmental and economic significance of technology selection for CDM projects. To take this further, we then reconsider the profitability of a project as typical FDI activity (i.e., without the CDM), and by comparing this outcome with the CDM case, we clarify the significance and potential of the CDM

Technological stakes of LHC, the large superconducting collider in project at CERN

International Nuclear Information System (INIS)

Lebrun, P.

1991-01-01

The LHC large superconducting particle collider project is presented, with particular emphasis on its major technological requirements and returns, mostly in the domains of high-field electromagnets, superfluid helium cryogenics, and integration of such advanced techniques in a large machine. The corresponding cooperation and technological transfer to European laboratories and industries are briefly discussed [fr

Some aspects concerning the implementation of a fuel technology project

International Nuclear Information System (INIS)

Andreescu, N.; Alecu, M.; Mirion, I.

1977-01-01

The nuclear power programme in Romania envisages that until 1990 there will be installed about 6000 MWe in nuclear power plants. In order to put into practice such a nuclear programme there will be necessary high investments, possible to be achieved only by the ever increasing participation of the Romanian industry. With a view to this purpose, the Romanian authorities pay great attention to the research and development of the nuclear fuel manufacturing technology. Some research started in 1968-1969 and was intensified later in 1971 when the Institute for Nuclear Technology was founded and in 1972 when the IAEA-UNDP programme ''Development of Nuclear Technology in Romania'' started. This programme was conceived to deal with; 1. technology of UO2 powder and pellet fabrication; 2. manufacturing technology of fuel rods and bundle; 3. irradiation test of fuel rods; 4. development of various activities connected to fuel technology (thermal transfer loops, corrosion tests, neutronic, thermal and hydrodynamical calculations). Within the IAEA-UNDP project a demonstration facility was installed at INT where a great number of the works, resulting from the above mentioned directions, were performed. As a result of these works, at the end of 1975 in the demonstration facility there were manufactured in a reproducible way fuel rods according to the required specifications. The paper further presents the adopted irradiation testing programme, the out-of-pile testing programme, as well as some performances obtained during the different phases of the whole project. There have been conceived and manufactured some equipment meant for fabrication, tests, or for current control. The paper also shows some aspects connected to the personnel formation, as well as some aspects that will have to be solved in order to make possible the step from the demonstration facility to a fuel plant

Using the regularities of high and critical technologies developing in innovative project management

Directory of Open Access Journals (Sweden)

S. G. Selivanov

2014-01-01

Full Text Available Problem-orientated to the innovative activity, computer-aided systems of production engineering (CASPE integrates design, manufacture, and organization activities using the interrelated innovation principles thus leaning the innovative activity towards the creation of innovative products and technological innovations of high science and technology level and efficiency. In this situation the innovative activity uses in practice not only the newest experience, but also the science laws and consequences, that is, in particular, “Science of Innovations”. The mentioned science laws explain wave dynamics of technical (technological systems development. In the course of innovation activities and/or innovation designing a modification of continuously acting technological system, usually, causes its developing and growing upwards by Sshaped curve. Changing a principle of action changes S-shaped curve development (Fig. 1. If such changes are within the certain “trace tube” we are entitled to state the steady system development.Analysis of changing target function of technological system within the “trace tube” of its steady development characterizes its growing wave dynamics (Fig. 1 using the S-shaped curves (sigmoid type relations. S-shaped innovative development relations of technological systems are, usually, explained by different mathematical models, each being in compliance with the certain process of science and technology. Singular innovative project management using the S-shaped curves can be explained by the following example (Fig.2.To use such management technique it is very important to know the mathematical models of S-curves for different types of innovation projects. That is why we consider given S-shaped relations in-detail for:- developing the high and critical technologies during R&D implementation using the cutting-edge CASSR (computer-aided systems of scientific research of high and critical technologies in innovation

Success Rates by Software Development Methodology in Information Technology Project Management: A Quantitative Analysis

Science.gov (United States)

Wright, Gerald P.

2013-01-01

Despite over half a century of Project Management research, project success rates are still too low. Organizations spend a tremendous amount of valuable resources on Information Technology projects and seek to maximize the utility gained from their efforts. The author investigated the impact of software development methodology choice on ten…

The International Stripa Project: Technology transfer from cooperation in scientific and technological research on nuclear waste disposal

International Nuclear Information System (INIS)

Levich, R.A.; Ferrigan, P.M.; Wilkey, P.L.

1990-01-01

The Nuclear Energy Agency of the organization for Economic Cooperation and Development (OECD/NEA) sponsors the International Stripa Project. The objectives of the Stripa Project are to develop techniques for characterizing sites located deep in rock formations that are potentially suitable for the geologic disposal of high-level radioactive wastes and to evaluate particular engineering design considerations that could enhance the long-term safety of a high-level radioactive waste repository in a geologic medium. The purpose of this paper is to briefly summarize the research conducted at Stripa and discuss the ways in which the technology developed for the Stripa Project has been and will be transfered to the United States Civilian Radioactive Waste Management Program's Yucca Mountain Project. 3 refs., 2 figs

Hanford's 100-HX Pump and Treat Project - a Successful Blend of Science, Technology, Construction, and Project Management - 12412

Energy Technology Data Exchange (ETDEWEB)

Albin, Kenneth A.; Bachand, Marie T.; Biebesheimer, Fred H.; Neshem, Dean O.; Smoot, John L. [CH2M HILL Plateau Remediation Company, Richland, Washington 99352 (United States)

2012-07-01

CH2M Hill Plateau Remediation Company (CHPRC) recently completed construction and start-up of the $25 million 100-HX Groundwater Pump and Treat Project for the Department of Energy (DOE) at its Hanford Reservation site in Washington State. From the onset, the 100-HX Project Leadership Team was able to successfully blend the science and technology of a state-of-the-art groundwater pump and treat system with the principles, tools, and techniques of traditional industrial-type construction and project management. From the 1940's through most of the 1980's, the United States used the Hanford Site to produce nuclear material for national defense at reactor sites located along the Columbia River. While the reactors were operational, large volumes of river water were treated with sodium dichromate (to inhibit corrosion of the reactor piping) and used as a coolant for the reactors. After a single pass through the reactor and before being discharged back to the river, the coolant water was sent to unlined retention basins to cool and to allow the short-lived radioactive contaminants to decay. As a result of these operations, hexavalent chromium was introduced to the vadose zone, and ultimately into the groundwater aquifer and the adjacent Columbia River. In addition, numerous leaks and spills of concentrated sodium dichromate stock solution over the lifetime of reactor operations led to higher concentrations of chromate in the vadose zone and groundwater in localized areas. As a result, the 100 Area was included in the National Priorities List sites under the Comprehensive Environmental Response Compensation and Liability Act of 1980 (CERCLA). The mission of the 100-HX Project is to significantly reduce the concentration of hexavalent chromium in the groundwater by treating up to 3.8 billion gallons (14,300 mega-liters) of contaminated water over its first nine years of operations. In order to accomplish this mission, groundwater scientists and geologists using

NEDO environmental technology subcommittee. 18th project report meeting; NEDO kankyo gijutsu bunkakai. Dai 18 kai jigyo hokokukai

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-09-01

In relation with the 'recent trends of global warming problems and the outline of environmental technology development office activities,' Hiroshi Mitsukawa, a NEDO (New Energy and Industrial Technology Development Organization) director, delivers a report on Japan's policy toward the international commitments of the Kyoto session of the Conference of the Parties to the United Nations Framework Convention on Climate Change and NEDO's approach in this connection to new energy technology development. Furthermore, global environment-related industry technology research and development projects are explained, which involve environmentally friendly production technology, reduction in substances that cause environmental impacts, effective use of CO2 fixation, recycling of wastes, environment restoration technology, international relationship, and so forth. In relation with the 'promotion of global warming prevention projects by the environmental technology development office,' researches for the promotion of joint implementation, climate technology initiative, international joint projects for CO2 isolation in the ocean, and IEA (International Energy Agency) agreement on the research and development of technologies related to greenhouse gas, are explained. Concerning the development of eco-cement production technology utilizing urbane type general wastes, a verification research project on the manufacture of cement from incinerated urbane waste residue and sewage sludge is reported. (NEDO)

OCTAVIUS: a FP7 project demonstrating CO2 capture technologies

NARCIS (Netherlands)

Broutin, P.; Kvamsdal, H.M.; La Marca, C.; Os, P.J. van; Robinson, L.

2014-01-01

The OCTAVIUS project (Optimisation of CO2 Capture Technology Allowing Verification and Implementation at Utility Scale) has started on March 1st 2012 for a period of 5 years, as part of the 7th Framework Programme of the European Commission. Gathering 15 European and 2 South African partners,

Learning in Authentic Contexts: Projects Integrating Spatial Technologies and Fieldwork

Science.gov (United States)

Huang, Kuo-Hung

2011-01-01

In recent years, professional practice has been an issue of concern in higher education. The purpose of this study is to design students' projects to facilitate collaborative learning in authentic contexts. Ten students majoring in Management Information Systems conducted fieldwork with spatial technologies to collect data and provided information…

Ceramic technology for advanced heat engines project. Semiannual progress report, April-September 1985

Energy Technology Data Exchange (ETDEWEB)

1986-05-01

An assessment of needs was completed, and a five-year project plan was developed with input from private industry. Objective is to develop the industrial technology base required for reliable ceramics for application in advanced automotive heat engines. Focus is on structural ceramics for advanced gas turbine and diesel engines, ceramic bearings and attachments, and ceramic coatings for thermal barrier and wear applications in these engines. The work described in this report is organized according to the following WBS project elements: management and coordination; materials and processing (monolithics, ceramic composites, thermal and wear coatings, joining); materials design methodology (contact interfaces, new concepts); data base and life prediction (time-dependent behavior, environmental effects, fracture mechanics, NDE development); and technology transfer. This report includes contributions from all currently active project participants.

Milliken Clean Coal Technology Demonstration Project. Environmental monitoring report, July--September 1996

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-05-01

New York State Electric and Gas Corporation (NYSEG) has installed and is presently operating a high-efficiency flue gas desulfurization (FGD) system to demonstrate innovative emissions control technology and comply with the Clean Air Act Amendments of 1990. The host facility for this demonstration project is NYSEG`s Milliken Station, in the Town of Lansing, New York. The primary objective of this project is to demonstrate a retrofit of energy-efficient SO{sub 2} and NO{sub x} control systems with minimal impact on overall plant efficiency. The demonstration project has added a forced oxidation, formic acid-enhanced wet limestone FGD system, which is expected to reduce SO{sub 2} emissions by at least 90 percent. NYSEG also made combustion modifications to each boiler and plans to demonstrate selective non-catalytic reduction (SNCR) technology on unit 1, which will reduce NO{sub x} emissions. Goals of the proposed demonstration include up to 98 percent SO{sub 2} removal efficiency while burning high-sulfur coal, 30 percent NO{sub x} reductions through combustion modifications, additional NO{sub x} reductions using SNCR technology, production of marketable commercial-grade gypsum and calcium chloride by-products to minimize solid waste disposal, and zero wastewater discharge.

Repair-welding technology of irradiated materials - WIM project

International Nuclear Information System (INIS)

Nakata, K.; Oishi, M.

1998-01-01

A new project on the development of repair-welding technology for core internals and reactor (pressure) vessel, consigned by the Ministry of International Trade and Industry (MITI), has been started from October 1997. The objective of the project is classified into three points as follows: (1) to develop repair-welding techniques for neutron irradiated materials, (2) to prove the availability of the techniques for core internals and reactor (pressure) vessel, and (3) to recommend the updated repair-welding for the Technical Rules and Standards. Total planning, neutron irradiation, preparation of welding equipment are now in progress. The materials are austenitic stainless steels and a low alloy steel. Neutron irradiation is performed using test reactors. In order to suppress the helium aggregation along grain boundaries, low heat input welding techniques, such as laser, low heat input TIG and friction weldings, will be applied. (author)

Report of the Project Research on Disaster Reduction using Disaster Mitigating Information Sharing Technology

Science.gov (United States)

Suzuki, Takeyasu

For the purpose of reducing disaster damage by applying information sharing technologies, "the research on disaster reduction using crisis-adaptive information sharing technologies" was carried out from July, 2004 through March 2007, as a three year joint project composed of a government office and agency, national research institutes, universities, lifeline corporations, a NPO and a private company. In this project, the disaster mitigating information sharing platform which is effective to disaster response activities mainly for local governments was developed, as a framework which enables information sharing in disasters. A prototype of the platform was built by integrating an individual system and tool. Then, it was applied to actual local governments and proved to be effective to disaster responses. This paper summarizes the research project. It defines the platform as a framework of both information contents and information systems first and describes information sharing technologies developed for utilization of the platform. It also introduces fields tests in which a prototype of the platform was applied to local governments.

Virtual Teaming and Collaboration Technology: A Study of Influences on Virtual Project Outcomes

Science.gov (United States)

Broils, Gary C.

2014-01-01

The purpose of this quantitative correlational study was to explore the relationships between the independent variables, contextual factors for virtual teams and collaboration technology, and the dependent variable, virtual project outcomes. The problem leading to the need for the study is a lower success rate for virtual projects compared to…

NMDA receptor activation and PKC but not PKA lead to the modification of the long-term potentiation in the insular cortex induced by conditioned taste aversion: differential role of kinases in metaplasticity.

Science.gov (United States)

Rodríguez-Durán, Luis F; Escobar, Martha L

2014-06-01

It has been reported that training in behavioral tasks modifies the ability to induce long-term potentiation (LTP) in an N-methyl-D-aspartate receptor (NMDAR)-dependent manner. This receptor leads to calcium entry into neuronal cells, promoting the activation of protein kinases as protein kinase A (PKA) and protein kinase C (PKC), which contribute significantly to the formation of different types of memories and play a pivotal role in the expression of LTP. Our previous studies involving the insular cortex (IC) have demonstrated that induction of LTP in the basolateral amygdaloid nucleus (BLA)-IC projection prior to conditioned taste aversion (CTA) training enhances the retention of this task. Recently, we showed that CTA training triggers a persistent impairment in the ability to induce subsequent synaptic plasticity on the BLA-IC pathway in a protein synthesis-dependent manner, but the underlying molecular mechanisms remain unclear. In the present study we investigated whether the blockade of NMDAR, as well as the inhibition of PKC and PKA affects the CTA-dependent impairment of the IC-LTP. Thus, CTA-trained rats received high frequency stimulation in the Bla-IC projection in order to induce LTP 48 h after the aversion test. The NMDAR antagonist CPP and the specific inhibitors for PKC (chelerythrine) and PKA (KT-5720) were intracortically administered during the acquisition session. Our results show that the blockade of NMDAR and the inhibition of PKC activity prevent the CTA memory-formation as well as the IC-LTP impairment. Nevertheless, PKA inhibition prevents the memory formation of taste aversion but produces no interference with the CTA-dependent impairment of the IC-LTP. These findings reveal the differential roles of protein kinases on CTA-dependent modification of IC-LTP enhancing our understanding of the effects of memory-related changes on synaptic function. Copyright © 2014 Elsevier B.V. All rights reserved.

Persuasive Technology for Learning and Teaching – The EuroPLOT Project

OpenAIRE

Behringer, R; Soosay, M; Gram-Hansen, SB; Øhrstrøm, P; Sørensen, CG; Smith, C; Mikulecká, J; Winther-Nielsen, N; Winther-Nielsen, M; Herber, E

2013-01-01

The concept of persuasive design has demonstrated its benefits by changing human behavior in certain situations, but in the area of education and learning, this approach has rarely been used. To change this and to study the feasibility of persuasive technology in teaching and learning, the EuroPLOT project (PLOT = Persuasive Learning Objects and Technologies) has been funded 2010-2013 by the Education, Audiovisual and Culture Executive Agency (EACEA) in the Life-long Learning (LLL) programme....

Optimizing Outcome in the University-Industry Technology Transfer Projects

Science.gov (United States)

Alavi, Hamed; Hąbek, Patrycja

2016-06-01

Transferring inventions of academic scientists to private enterprises for the purpose of commercialization is long known as University-Industry (firm) Technology Transfer While the importance of this phenomenon is simultaneously raising in public and private sector, only a part of patented academic inventions succeed in passing the process of commercialization. Despite the fact that formal Technology Transfer process and licencing of patented innovations to third party is the main legal tool for safeguarding rights of academic inventors in commercialization of their inventions, it is not sufficient for transmitting tacit knowledge which is necessary in exploitation of transferred technology. Existence of reciprocal and complementary relations between formal and informal technology transfer process has resulted in formation of different models for university-industry organizational collaboration or even integration where licensee firms keep contact with academic inventors after gaining legal right for commercialization of their patented invention. Current paper argues that despite necessity for patents to legally pass the right of commercialization of an invention, they are not sufficient for complete knowledge transmission in the process of technology transfer. Lack of efficiency of formal mechanism to end the Technology Transfer loop makes an opportunity to create innovative interpersonal and organizational connections among patentee and licensee company. With emphasize on need for further elaboration of informal mechanisms as critical and underappreciated aspect of technology transfer process, article will try to answer the questions of how to optimize knowledge transmission process in the framework of University-Industry Technology Transfer Projects? What is the theoretical basis for university-industry technology transfer process? What are organization collaborative models which can enhance overall performance by improving transmission of knowledge in

ITER project and fusion technology

International Nuclear Information System (INIS)

Takatsu, H.

2011-01-01

In the sessions of ITR, FTP and SEE of the 23rd IAEA Fusion Energy Conference, 159 papers were presented in total, highlighted by the remarkable progress of the ITER project: ITER baseline has been established and procurement activities have been started as planned with a target of realizing the first plasma in 2019; ITER physics basis is sound and operation scenarios and operational issues have been extensively studied in close collaboration with the worldwide physics community; the test blanket module programme has been incorporated into the ITER programme and extensive R and D works are ongoing in the member countries with a view to delivering their own modules in a timely manner according to the ITER master schedule. Good progress was also reported in the areas of a variety of complementary activities to DEMO, including Broader Approach activities and long-term technology. This paper summarizes the highlights of the papers presented in the ITR, FTP and SEE sessions with a minimum set of background information.

The magnetic diagnostics subsystem of the LISA Technology Package

Energy Technology Data Exchange (ETDEWEB)

Diaz-Aguilo, M; Garcia-Berro, E [Departament de Fisica Aplicada, Universitat Politecnica de Catalunya, c/Esteve Terrades, 5, 08860 Castelldefels (Spain); Lobo, A; Mateos, N; Sanjuan, J, E-mail: marc.diaz.aguilo@fa.upc.ed [Institut d' Estudis Espacials de Catalunya, c/Gran Capita 2-4, Edif. Nexus 104, 08034 Barcelona (Spain)

2010-05-01

The Magnetic Diagnostics Subsystem of the LISA Technology Package (LTP) on board the LISA Pathfinder (LPF) spacecraft includes a set of four tri-axial fluxgate magnetometers, intended to measure with high precision the magnetic field at the positions they occupy. However, their readouts do not provide a direct measurement of the magnetic field at the positions of the test masses. Therefore, an interpolation method must be implemented to obtain this information. However, such interpolation process faces serious difficulties. Indeed, the size of the interpolation region is excessive for a linear interpolation to be reliable, and the number of magnetometer channels does not provide sufficient data to go beyond that poor approximation. Recent research points to a possible alternative to address the magnetic interpolation problem by means of neural network algorithms. The key point of this approach is the ability neural networks have to learn from suitable training data representing the magnetic field behaviour. Despite the large distance to the test masses and the insufficient magnetic readings, artificial neural networks are able to significantly reduce the estimation error to acceptable levels. The learning efficiency can be best improved by making use of data obtained from on-ground measurements prior to mission launch in all relevant satellite locations and under real operation conditions. Reliable information on that appears to be essential for a meaningful assessment of magnetic noise in the LTP.

The magnetic diagnostics subsystem of the LISA Technology Package

International Nuclear Information System (INIS)

Diaz-Aguilo, M; Garcia-Berro, E; Lobo, A; Mateos, N; Sanjuan, J

2010-01-01

The Magnetic Diagnostics Subsystem of the LISA Technology Package (LTP) on board the LISA Pathfinder (LPF) spacecraft includes a set of four tri-axial fluxgate magnetometers, intended to measure with high precision the magnetic field at the positions they occupy. However, their readouts do not provide a direct measurement of the magnetic field at the positions of the test masses. Therefore, an interpolation method must be implemented to obtain this information. However, such interpolation process faces serious difficulties. Indeed, the size of the interpolation region is excessive for a linear interpolation to be reliable, and the number of magnetometer channels does not provide sufficient data to go beyond that poor approximation. Recent research points to a possible alternative to address the magnetic interpolation problem by means of neural network algorithms. The key point of this approach is the ability neural networks have to learn from suitable training data representing the magnetic field behaviour. Despite the large distance to the test masses and the insufficient magnetic readings, artificial neural networks are able to significantly reduce the estimation error to acceptable levels. The learning efficiency can be best improved by making use of data obtained from on-ground measurements prior to mission launch in all relevant satellite locations and under real operation conditions. Reliable information on that appears to be essential for a meaningful assessment of magnetic noise in the LTP.

International exchange project for the engineer exchange project (in coal mine technology area) in fiscal 1998. Overseas workshop; 1998 nendo gijutsusha koryu jigyo (tanko gijutsu bun'ya) kokusai koryu jigyo. Kaigai workshop

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-03-01

The international exchange project for the engineer exchange project (in coal mine technology area) in fiscal 1998, the 'Overseas workshop' has performed exchange in technologies with Australian coal mine engineers. The project refers to the Australian technological levels and needs in coal production, safety control and environment, as well as transfer of the Japanese coal mine technologies. This report summarizes the result of a survey on the engineer exchange project in the coal mine technology area and the possibility of joint researches. The 'overseas workshop' was held in November 1998 for two days in Brisbane City in QLD Province as the 'Japan-Australia coal technology workshop'. The 'Japan-Australia coal technology workshop' gave lectures in five sessions (the basic lecture, Japan-Australia high-speed excavation project, coal mine gas control project, exploration and resources, and development and experience of Japan). It also discussed two themes (mine safety management and rules, and greenhouse effect gases and coal mining). Two coal mines were visited thereafter to deepen the exchange with the Australian coal mine engineers. (NEDO)

Network models for solving the problem of multicriterial adaptive optimization of investment projects control with several acceptable technologies

Science.gov (United States)

Shorikov, A. F.; Butsenko, E. V.

2017-10-01

This paper discusses the problem of multicriterial adaptive optimization the control of investment projects in the presence of several technologies. On the basis of network modeling proposed a new economic and mathematical model and a method for solving the problem of multicriterial adaptive optimization the control of investment projects in the presence of several technologies. Network economic and mathematical modeling allows you to determine the optimal time and calendar schedule for the implementation of the investment project and serves as an instrument to increase the economic potential and competitiveness of the enterprise. On a meaningful practical example, the processes of forming network models are shown, including the definition of the sequence of actions of a particular investment projecting process, the network-based work schedules are constructed. The calculation of the parameters of network models is carried out. Optimal (critical) paths have been formed and the optimal time for implementing the chosen technologies of the investment project has been calculated. It also shows the selection of the optimal technology from a set of possible technologies for project implementation, taking into account the time and cost of the work. The proposed model and method for solving the problem of managing investment projects can serve as a basis for the development, creation and application of appropriate computer information systems to support the adoption of managerial decisions by business people.

Integration of advanced technologies to enhance problem-based learning over distance: Project TOUCH.

Science.gov (United States)

Jacobs, Joshua; Caudell, Thomas; Wilks, David; Keep, Marcus F; Mitchell, Steven; Buchanan, Holly; Saland, Linda; Rosenheimer, Julie; Lozanoff, Beth K; Lozanoff, Scott; Saiki, Stanley; Alverson, Dale

2003-01-01

Distance education delivery has increased dramatically in recent years as a result of the rapid advancement of communication technology. The National Computational Science Alliance's Access Grid represents a significant advancement in communication technology with potential for distance medical education. The purpose of this study is to provide an overview of the TOUCH project (Telehealth Outreach for Unified Community Health; http://hsc.unm.edu/touch) with special emphasis on the process of problem-based learning case development for distribution over the Access Grid. The objective of the TOUCH project is to use emerging Internet-based technology to overcome geographic barriers for delivery of tutorial sessions to medical students pursuing rotations at remote sites. The TOUCH project also is aimed at developing a patient simulation engine and an immersive virtual reality environment to achieve a realistic health care scenario enhancing the learning experience. A traumatic head injury case is developed and distributed over the Access Grid as a demonstration of the TOUCH system. Project TOUCH serves as an example of a computer-based learning system for developing and implementing problem-based learning cases within the medical curriculum, but this system should be easily applied to other educational environments and disciplines involving functional and clinical anatomy. Future phases will explore PC versions of the TOUCH cases for increased distribution. Copyright 2003 Wiley-Liss, Inc.

THE THEORETIC-METHODOLOGICAL TOOLS OF EFFECTIVE ESTIMATION OF ORGANIZATION TECHNOLOGICAL SOLUTIONS OF CONSTRUCTION PROJECT

Directory of Open Access Journals (Sweden)

E. Yu. Antipenko

2010-03-01

Full Text Available In the article the structural analysis of efficiency indices elements of organization-and-technology solutions of construction project scheduling is executed for preparation of high-quality base of providing the planning processes and subsequent realization of the projects.

Integrated learning of mathematics, science and technology concepts through LEGO/Logo projects

Science.gov (United States)

Wu, Lina

This dissertation examined integrated learning in the domains of mathematics, science and technology based on Piaget's constructivism, Papert's constructionism, and project-based approach to education. Ten fifth grade students were involved in a two-month long after school program where they designed and built their own computer-controlled LEGO/Logo projects that required the use of gears, ratios and motion concepts. The design of this study centered on three notions of integrated learning: (1) integration in terms of what educational materials/settings provide, (2) integration in terms of students' use of those materials, and (3) integration in the psychological sense. In terms of the first notion, the results generally showed that the LEGO/Logo environment supported the integrated learning of math, science and technology concepts. Regarding the second notion, the students all completed impressive projects of their own design. They successfully combined gears, motors, and LEGO parts together to create motion and writing control commands to manipulate the motion. But contrary to my initial expectations, their successful designs did not require numerical reasoning about ratios in designing effective gear systems. When they did reason about gear relationships, they worked with "qualitative" ratios, e.g., "a larger driver gear with a smaller driven gear increases the speed." In terms of the third notion of integrated learning, there was evidence in all four case study students of the psychological processes involved in linking mathematical, scientific, and/or technological concepts together to achieve new conceptual units. The students not only made connections between ideas and experiences, but also recognized decisive patterns and relationships in their project work. The students with stronger overall project performances showed more evidence of synthesis than the students with relatively weaker performances did. The findings support the conclusion that all three

Technological Education for the Rural Community (TERC) Project: Technical Mathematics for the Advanced Manufacturing Technician

Science.gov (United States)

McCormack, Sherry L.; Zieman, Stuart

2017-01-01

Hopkinsville Community College's Technological Education for the Rural Community (TERC) project is funded through the National Science Foundation Advanced Technological Education (NSF ATE) division. It is advancing innovative educational pathways for technological education promoted at the community college level serving rural communities to fill…

Comprehensive report to Congress Clean Coal Technology Program. Four Rivers Energy Modernization Project

Energy Technology Data Exchange (ETDEWEB)

1994-06-01

One of the five projects selected for funding within the Clean Coal Technology Program is a project proposed by Air Products and Chemicals, Inc. (APCI) of Allentown, Pennsylvania. APCI requested financial assistance from DOE for the design, construction, and operation of a 95 megawatt-electric (MWe) gross equivalent, second generation, pressurized, circulating fluidized bed (PCFB) combustor cogeneration facility. The project, named the Four Rivers Energy Modernization Project, is co be located adjacent to an existing APCI chemicals manufacturing facility in Calvert City, Kentucky. Four Rivers Energy Partners, L.P. (FREP), will execute the project. The demonstration plant will produce approximately 70 MWe for the utility grid and an average of 310,000 pounds per hour of process steam for the chemicals manufacturing facility. The project, including the demonstration phase, will last 80 months at a total cost of $360,707,500. DOE`s share of the project cost will be 39.5 percent, or $142,460,000. The objective of the proposed project is to demonstrate a second generation PCFB system based on technology being supplied by Foster Wheeler Energy Corporation (FWEC), Westinghouse Electric Corporation (Westinghouse), and LLB Lurgi Lentjes Babcock Energietechnik GmbH (LLB). The integrated performance to be demonstrated will involve all of the process systems, including coal preparation and feed, sorbent feed, carbonizer, char transfer, PCFB combustor, carbonizer and combustor hot-gas filtration, carbonizer and combustor alkali removal, topping combustor, gas turbine-generator, heat recovery steam generator (HRSG), steam turbine-generator, and balance-of-plant systems. The project will utilize Western Kentucky and Southern Illinois bituminous coal.

High definition TV projection via single crystal faceplate technology

Science.gov (United States)

Kindl, H. J.; St. John, Thomas

1993-03-01

Single crystal phosphor faceplates are epitaxial phosphors grown on crystalline substrates with the advantages of high light output, resolution, and extended operational life. Single crystal phosphor faceplate industrial technology in the United States is capable of providing a faceplate appropriate to the projection industry of up to four (4) inches in diameter. Projection systems incorporating cathode ray tubes utilizing single crystal phosphor faceplates will produce 1500 lumens of white light with 1000 lines of resolution, non-interlaced. This 1500 lumen projection system will meet all of the currently specified luminance and resolution requirements of Visual Display systems for flight simulators. Significant logistic advantages accrue from the introduction of single crystal phosphor faceplate CRT's. Specifically, the full performance life of a CRT is expected to increase by a factor of five (5); ie, from 2000 to 10,000 hours of operation. There will be attendant reductions in maintenance time, spare CRT requirements, system down time, etc. The increased brightness of the projection system will allow use of lower gain, lower cost simulator screen material. Further, picture performance characteristics will be more balanced across the full simulator.

Innovation capabilities in food and beverages and technology-based innovation projects

NARCIS (Netherlands)

Tepic, M.; Fortuin, F.T.J.M.; Kemp, R.G.M.; Omta, S.W.F.

2014-01-01

Purpose - The aim of this paper is to establish the differences between the food and beverages (F&B) and technology-based industries with regards to the relation between previously identified success factors and innovation project performance. Design/methodology/approach - These differences are

Improvising information technology projects through the duality of structure

Directory of Open Access Journals (Sweden)

Tiko Iyamu

2017-08-01

Full Text Available Background: There is always emphasis on information technology (IT projects because of their significance in organisations. Thus, efforts and resources are reciprocally committed to ensure the successes. Still, failure of IT projects in many organisations remains high and affects competitiveness. As recourse for remedy, different techniques and approaches have been employed. However, little or no progress has been made in increasing the success rate of IT projects in many organisations. Objectives: The objective of this study was to examine the factors that influence and impact IT projects, improvisation and how improvisation manifests. Method: The study was carried out using a single case study approach. Qualitative data were collected and duality of structure from the perspective of structuration theory was used as lens to guide the analysis. Results: Findings from this study reveal how reproduction of actions manifests from non-technical factors, such as cultural value, organisational structure, power relationship, human capacity, know-how and change management. These factors help to gain a more constructive and better understanding of how IT projects improvisation is influenced or impacted by non-technical factors in organisations. Conclusion: The study is intended to benefit both practitioners and academics. Some of the benefits will be gained from fresh perspectives on the complexities of IT projects improvisation, which are often caused by various seen and unforeseen non-technical factors. This includes how actions from relationship, know-how about facilities and communicative scheme are produced and reproduced.

Expansion of Michigan EOR Operations Using Advanced Amine Technology at a 600 MW Project Wolverine Carbon Capture and Storage Project

Energy Technology Data Exchange (ETDEWEB)

H Hoffman; Y kishinevsky; S. Wu; R. Pardini; E. Tripp; D. Barnes

2010-06-16

Wolverine Power Supply Cooperative Inc, a member owned cooperative utility based in Cadillac Michigan, proposes to demonstrate the capture, beneficial utilization and storage of CO{sub 2} in the expansion of existing Enhanced Oil Recovery operations. This project is being proposed in response to the US Department of Energy Solicitation DE-FOA-0000015 Section III D, 'Large Scale Industrial CCS projects from Industrial Sources' Technology Area 1. The project will remove 1,000 metric tons per day of CO{sub 2} from the Wolverine Clean Energy Venture 600 MW CFB power plant owned and operated by WPC. CO{sub 2} from the flue gas will be captured using Hitachi's CO{sub 2} capture system and advanced amine technology. The capture system with the advanced amine-based solvent supplied by Hitachi is expected to significantly reduce the cost and energy requirements of CO{sub 2} capture compared to current technologies. The captured CO{sub 2} will be compressed and transported for Enhanced Oil Recovery and CO{sub 2} storage purposes. Enhanced Oil Recovery is a proven concept, widely used to recover otherwise inaccessible petroleum reserves. While post-combustion CO{sub 2} capture technologies have been tested at the pilot scale on coal power plant flue gas, they have not yet been demonstrated at a commercial scale and integrated with EOR and storage operations. Amine-based CO{sub 2} capture is the leading technology expected to be available commercially within this decade to enable CCS for utility and industrial facilities firing coal and waste fuels such as petroleum coke. However, traditional CO{sub 2} capture process utilizing commercial amine solvents is very energy intensive for regeneration and is also susceptible to solvent degradation by oxygen as well as SOx and NO{sub 2} in the flue gas, resulting in large operating costs. The large volume of combustion flue gas with its low CO{sub 2} concentration requires large equipment sizes, which together with the

TANK FARM REMEDIATION TECHNOLOGY DEVELOPMENT PROJECT AN EXERCISE IN TECHNICAL & REGULATORY COLLABORATION

Energy Technology Data Exchange (ETDEWEB)

JARAYSI, M.N.

2007-01-08

The Tank Farm Remediation Technology Development Project at the Hanford Site focuses on waste storage tanks, pipelines and associated ancillary equipment that are part of the C-200 single-shell tank (SST) farm system located in the C Tank Farm. The purpose of the project is to obtain information on the implementation of a variety of closure activities and to answer questions on technical, operational and regulatory issues associated with closure.

Global emission projections for the transportation sector using dynamic technology modeling

Science.gov (United States)

Yan, F.; Winijkul, E.; Streets, D. G.; Lu, Z.; Bond, T. C.; Zhang, Y.

2014-06-01

In this study, global emissions of gases and particles from the transportation sector are projected from the year 2010 to 2050. The Speciated Pollutant Emission Wizard (SPEW)-Trend model, a dynamic model that links the emitter population to its emission characteristics, is used to project emissions from on-road vehicles and non-road engines. Unlike previous models of global emission estimates, SPEW-Trend incorporates considerable detail on the technology stock and builds explicit relationships between socioeconomic drivers and technological changes, such that the vehicle fleet and the vehicle technology shares change dynamically in response to economic development. Emissions from shipping, aviation, and rail are estimated based on other studies so that the final results encompass the entire transportation sector. The emission projections are driven by four commonly-used IPCC (Intergovernmental Panel on Climate Change) scenarios (A1B, A2, B1, and B2). With global fossil-fuel use (oil and coal) in the transportation sector in the range of 128-171 EJ across the four scenarios, global emissions are projected to be 101-138 Tg of carbon monoxide (CO), 44-54 Tg of nitrogen oxides (NOx), 14-18 Tg of non-methane total hydrocarbons (THC), and 3.6-4.4 Tg of particulate matter (PM) in the year 2030. At the global level, a common feature of the emission scenarios is a projected decline in emissions during the first one or two decades (2010-2030), because the effects of stringent emission standards offset the growth in fuel use. Emissions increase slightly in some scenarios after 2030, because of the fast growth of on-road vehicles with lax or no emission standards in Africa and increasing emissions from non-road gasoline engines and shipping. On-road vehicles and non-road engines contribute the most to global CO and THC emissions, while on-road vehicles and shipping contribute the most to NOx and PM emissions. At the regional level, Latin America and East Asia are the two

OPTIMIZING OUTCOME IN THE UNIVERSITY-INDUSTRY TECHNOLOGY TRANSFER PROJECTS

Directory of Open Access Journals (Sweden)

Hamed ALAVI

2016-04-01

Full Text Available Transferring inventions of academic scientists to private enterprises for the purpose of commercialization is long known as University-Industry (firm Technology Transfer While the importance of this phenomenon is simultaneously raising in public and private sector, only a part of patented academic inventions succeed in passing the process of commercialization. Despite the fact that formal Technology Transfer process and licencing of patented innovations to third party is the main legal tool for safeguarding rights of academic inventors in commercialization of their inventions, it is not sufficient for transmitting tacit knowledge which is necessary in exploitation of transferred technology. Existence of reciprocal and complementary relations between formal and informal technology transfer process has resulted in formation of different models for university-industry organizational collaboration or even integration where licensee firms keep contact with academic inventors after gaining legal right for commercialization of their patented invention. Current paper argues that despite necessity for patents to legally pass the right of commercialization of an invention, they are not sufficient for complete knowledge transmission in the process of technology transfer. Lack of efficiency of formal mechanism to end the Technology Transfer loop makes an opportunity to create innovative interpersonal and organizational connections among patentee and licensee company. With emphasize on need for further elaboration of informal mechanisms as critical and underappreciated aspect of technology transfer process, article will try to answer the questions of how to optimize knowledge transmission process in the framework of University-Industry Technology Transfer Projects? What is the theoretical basis for university-industry technology transfer process? What are organization collaborative models which can enhance overall performance by improving transmission of

The K-8 Aeronautics Internet Textbook

Science.gov (United States)

2002-01-01

Efforts were focused on web site migration, from UC (University of California) Davis to the National Business Aviation Association's (NBAA) web site. K8AIT (K-8 Aeronautics Internet Textbook), which has remained an unadvertised web site, receives almost two million hits per month. Project continuation funding with the National Business Aviation Association is being pursued. A Memorandum of Understanding (MOU) between NASA Ames LTP (Learning Technologies Project) and Cislunar has been drafted and approved by NASA's legal department. Additional web content on space flight and the Wright brothers has been added in English and Spanish.

Proceedings of the Nuclear Criticality Technology and Safety Project Workshop

Energy Technology Data Exchange (ETDEWEB)

Sanchez, R.G. [comp.

1994-01-01

This report is the proceedings of the annual Nuclear Criticality Technology and Safety Project (NCTSP) Workshop held in Monterey, California, on April 16--28, 1993. The NCTSP was sponsored by the Department of Energy and organized by the Los Alamos Critical Experiments Facility. The report is divided into six sections reflecting the sessions outlined on the workshop agenda.

Proceedings of the Nuclear Criticality Technology and Safety Project Workshop

International Nuclear Information System (INIS)

Sanchez, R.G.

1994-01-01

This report is the proceedings of the annual Nuclear Criticality Technology and Safety Project (NCTSP) Workshop held in Monterey, California, on April 16--28, 1993. The NCTSP was sponsored by the Department of Energy and organized by the Los Alamos Critical Experiments Facility. The report is divided into six sections reflecting the sessions outlined on the workshop agenda

International exchange project for the engineer exchange project (in coal mine technology area) in fiscal 1998. Overseas workshop; 1998 nendo gijutsusha koryu jigyo (tanko gijutsu bun'ya) kokusai koryu jigyo. Kaigai workshop

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-03-01

The international exchange project for the engineer exchange project (in coal mine technology area) in fiscal 1998, the 'Overseas workshop' has performed exchange in technologies with Australian coal mine engineers. The project refers to the Australian technological levels and needs in coal production, safety control and environment, as well as transfer of the Japanese coal mine technologies. This report summarizes the result of a survey on the engineer exchange project in the coal mine technology area and the possibility of joint researches. The 'overseas workshop' was held in November 1998 for two days in Brisbane City in QLD Province as the 'Japan-Australia coal technology workshop'. The 'Japan-Australia coal technology workshop' gave lectures in five sessions (the basic lecture, Japan-Australia high-speed excavation project, coal mine gas control project, exploration and resources, and development and experience of Japan). It also discussed two themes (mine safety management and rules, and greenhouse effect gases and coal mining). Two coal mines were visited thereafter to deepen the exchange with the Australian coal mine engineers. (NEDO)

Policy implications of endogenous technological learning: some conclusions of the EU JOULE III project TEEM

International Nuclear Information System (INIS)

Kypreos, S.; Barreto, L.

2000-01-01

The TEEM (Energy Technology Dynamics and Advanced System Modelling) project focused activities on the role that technology and R and D spending could play for the mitigation of climatic change. The primary objectives of the PSI team were to share experience with other model developers in Europe, to expand the modelling capabilities, to contribute to quantitative analyses on the diffusion of innovative technologies, and to gain insights on the public energy research and development strategies. The paper describes the main findings of some scenarios on CO 2 mitigation for the global electricity system based on analyses using the multi-regional version of the ERIS prototype model, developed during the project. (authors)

The sweet-home project: audio technology in smart homes to improve well-being and reliance.

Science.gov (United States)

Vacher, Michel; Istrate, Dan; Portet, François; Joubert, Thierry; Chevalier, Thierry; Smidtas, Serge; Meillon, Brigitte; Lecouteux, Benjamin; Sehili, Mohamed; Chahuara, Pedro; Méniard, Sylvain

2011-01-01

The Sweet-Home project aims at providing audio-based interaction technology that lets the user have full control over their home environment, at detecting distress situations and at easing the social inclusion of the elderly and frail population. This paper presents an overview of the project focusing on the multimodal sound corpus acquisition and labelling and on the investigated techniques for speech and sound recognition. The user study and the recognition performances show the interest of this audio technology.

Requirements for effective technology transfer for engineering and project management. The views of the recipient country and the technology supplier

International Nuclear Information System (INIS)

Backhaus, K.W.

1986-04-01

Technology transfer in the area of engineering and project management for nuclear power plant projects is considered a rather complex and sophisticated matter. Therefore only within a long-term nuclear co-operation a meaningful transfer of such a multifaceted technology can reasonably be achieved. A long-term nuclear co-operation anticipates a nuclear power plant program consisting of a few nuclear power plants of a certain type and size in order to achieve the indispensable effect ''learning by doing''. The objectives of nuclear technology transfer may be in general or in particular; absorption of a foreign nuclear technology and its adaptation to the conditions and needs of the receiver's country; built-up of industrial infrastructure for planning, construction and operation of nuclear power plants; raising of the general industrial level and achieve a spin-off effect; creation of a basis for independent development of nuclear technology. The technology transfer on one side and the construction program of nuclear power plants on the other side cannot be practiced by two parallel but separated event, however, they form one unit. Contrary to the import of industrial equipment in terms of ''black box'', by means of a nuclear technology transfer the introduction of new dependencies will be prevented. The technology transfer can remarkably be facilitated by forming a joint venture engineering company in the recipient country. The required know-how potential within a certain time period determines the intensity of the technology transfer and consequently the man power to be involved. The realization of such technology transfer is demonstrated by means of practical examples. (author). 12 figs

Manual for research, development and technology program and project evaluations : final report.

Science.gov (United States)

2016-04-01

This manual provides the Federal Railroad Administrations (FRA) Office of Research, Development and Technology (RD&T) a : framework, standards, and procedures for planning, conducting, reporting, and using sound evaluations of RD&Ts projects fo...

Fire protection research for energy technology projects; FY 79 year-end report

International Nuclear Information System (INIS)

Hasegawa, H.K.; Alvares, N.J.; Lipska, A.E.; Ford, H.; Beason, D.G.

1981-01-01

This report describes work performed in fiscal year 1979, on a DOE funded study entitled Fire Protection Research for Energy Technology Projects. The primary goal of this program is to ensure that fire protection measures for Fusion Energy Experiments (FEE) evolve concurrently with the complexity of FEE. Ultimately, it is planned that the detailed study of fusion experiments will provide an analytical methodology which can be applied to the full range of energy technology projects. We attempt to achieve this objective by coordinately advancing 3 (three) major task areas; (a) determine the fire hazards of current FEE facilities (b) assess the ability of accepted fire management strategies to meet and negate the hazard, (c) perform unique research into problem areas we have identified to provide input into analytical fire growth and damage assessment models

Synthesizing R&D Data: Experiences from the Integrated Manufacturing Technology Roadmap (IMTR) Project

Energy Technology Data Exchange (ETDEWEB)

merrell, m.a.

1999-05-05

IMTR is a tremendous undertaking to assess the current state and future needs of Manufacturing Technology R&D. A follow-on project to the roadmaps is the development and populating of a Gap Analysis database containing current R&D abstracts related to the roadmaps' technical elements. Efficiently identifying the R&D projects within scope presents many travails of synthesizing data from across a wide spectrum. Challenges to this project were directly proportional to the lack of single-source data collections.

The role of absorptive capactiy in technological learning in CDM projects : evidences from survey in Brazil, China, India and Mexico

NARCIS (Netherlands)

Doranova, A.; Costa, I.; Duysters, G.M.

2011-01-01

Technology transfer in Clean Development Mechanism (CDM) projects of the Kyoto Protocol has acquired increasing attention of policy makers and academia. This study is an effort to investigate CDM projects' related technology transfer process from the organisational learning and technological

The role of absorptive capacity in technological learning in CDM projects : Evidences from survey in Brazil, China, India and Mexico

NARCIS (Netherlands)

Doranova, A.; Costa, I.; Duijsters, G.M.

2011-01-01

Technology transfer in Clean Development Mechanism (CDM) projects of the Kyoto Protocol has acquired increasing attention of policy makers and academia. This study is an effort to investigate CDM projects' related technology transfer process from the organisational learning and technological

Proceedings of the first annual Nuclear Criticality Safety Technology Project

International Nuclear Information System (INIS)

Rutherford, D.A.

1994-09-01

This document represents the published proceedings of the first annual Nuclear Criticality Safety Technology Project (NCSTP) Workshop, which took place May 12--14, 1992, in Gaithersburg, Md. The conference consisted of four sessions, each dealing with a specific aspect of nuclear criticality safety issues. The session titles were ''Criticality Code Development, Usage, and Validation,'' ''Experimental Needs, Facilities, and Measurements,'' ''Regulation, Compliance, and Their Effects on Nuclear Criticality Technology and Safety,'' and ''The Nuclear Criticality Community Response to the USDOE Regulations and Compliance Directives.'' The conference also sponsored a Working Group session, a report of the NCSTP Working Group is also presented. Individual papers have been cataloged separately

76 FR 56406 - Science and Technology Reinvention Laboratory Demonstration Project; Department of the Army; Army...

Science.gov (United States)

2011-09-13

... DEPARTMENT OF DEFENSE Office of the Secretary Science and Technology Reinvention Laboratory Demonstration Project; Department of the Army; Army Research, Development and Engineering Command; Tank... personnel management demonstration project for eligible TARDEC employees. Within that notice the table...

Benefits from the U.S. photovoltaic manufacturing technology project

Energy Technology Data Exchange (ETDEWEB)

Mitchell, R.L.; Witt, C.E.; Thomas, H.P. [National Renewable Energy Lab., Golden, CO (United States)] [and others

1996-05-01

This paper examines the goals of the Photovoltaic Manufacturing Technology (PVMaT) project and its achievements in recapturing the investment by the photovoltaic (PV) industry and the public in this research. The PVMaT project was initiated in 1990 with the goal of enhancing the world-wide competitiveness of the U.S. PV industry. Based on the authors analysis, PVMaT has contributed to PV module manufacturing process improvements, increased product value, and reductions in the price of today`s PV products. An evaluation of success in this project was conducted using data collected from 10 of the PVMaT industrial participants in late fiscal year (FY) 1995. These data indicate a reduction of 56% in the weighted average module manufacturing costs from 1992 to 1996. During this same period, U.S. module manufacturing capacity has increased by more than a factor of 6. Finally, the analysis indicates that both the public and the manufacturers will recapture the funds expended in R&D manufacturing improvements well before the year 2000.

NASA's nuclear electric propulsion technology project

International Nuclear Information System (INIS)

Stone, J.R.; Sovey, J.S.

1992-07-01

The National Aeronautics and Space Administration (NASA) has initiated a program to establish the readiness of nuclear electric propulsion (NEP) technology for relatively near-term applications to outer planet robotic science missions with potential future evolution to system for piloted Mars vehicles. This program was initiated in 1991 with a very modest effort identified with nuclear thermal propulsion (NTP); however, NEP is also an integral part of this program and builds upon NASA's Base Research and Technology Program in power and electric propulsion as well as the SP-100 space nuclear power program. The NEP Program will establish the feasibility and practicality of electric propulsion for robotic and piloted solar system exploration. The performance objectives are high specific impulse (200 greater than I(sub sp) greater than 10000 s), high efficiency (over 0.50), and low specific mass. The planning for this program was initially focussed on piloted Mars missions, but has since been redirected to first focus on 100-kW class systems for relatively near-term robotic missions, with possible future evolution to megawatt-and multi-megawatt-class systems applicable to cargo vehicles supporting human missions as well as to the piloted vehicles. This paper reviews current plans and recent progress for the overall nuclear electric propulsion project and closely related activities. 33 refs

Ceramic Technology Project data base: September 1992 summary report

Energy Technology Data Exchange (ETDEWEB)

Keyes, B.L.P.

1993-06-01

Data presented in this report represent an intense effort to improve processing methods, testing methods, and general mechanical properties (rupture modulus, tensile, creep, stress-rupture, dynamic and cyclic fatigue, fracture toughness) of candidate ceramics for use in advanced heat engines. This work was performed by many facilities and represents only a small part of the data generated by the Ceramic Technology Project (CTP) since 1986. Materials discussed include GTE PY6, GN-10, NT-154, NT-164, SN-260, SN-251, SN-252, AY6, silicon nitride combined with rare-earth oxides, Y-TZP, ZTA, NC-433, NT-230, Hexoloy SA, MgO-PSZ-to-MgO-PSZ joints, MgO-PSZ-to-cast iron, and a few whisker/fiber-reinforced ceramics. Information in this report was taken from the project`s semiannual and bimonthly progress reports and from final reports summarizing the results of individual studies. Test results are presented in tabular form and in graphs. All data, including test rig descriptions and material characterizations, are stored in the CTP data base and are available to all project participants on request. The objective of this report is to make available the test results from these studies but not to draw conclusions from those data.

The International Science and Technology Center (ISTC) and ISTC projects related to nuclear safety. Information review

International Nuclear Information System (INIS)

Tocheny, Lev V.

2003-01-01

The ISTC is an intergovernmental organization created ten years ago by Russia, USA, EU and Japan in Moscow. The Center supports numerous science and technology projects in different areas, from biotechnologies and environmental problems to all aspects of nuclear studies, including those focused on the development of effective innovative concepts and technologies in the nuclear field, in general, and for improvement of nuclear safety, in particular. The presentation addresses some technical results of the ISTC projects as well as methods and approaches employed by the ISTC to foster close international collaboration and manage projects towards fruitful results. (author)

OCTAVIUS: a new FP7 project demonstrating CO2 capture technologies

NARCIS (Netherlands)

Broutin, P.; Kvamsdal, H.M.; Marca, C. la; Os, P.J. van; Booth, N.

2013-01-01

The OCTAVIUS project (Optimisation of CO2 Capture Technology Allowing Verification and Implementation at Utility Scale) has started on March 1st 2012 for a period of 5 years, as part of the 7th Framework Programme of the European Commission. Gathering 15 European and 2 South African partners,

A Costing Model for Project-Based Information and Communication Technology Systems

Science.gov (United States)

Stewart, Brian; Hrenewich, Dave

2009-01-01

A major difficulty facing IT departments is ensuring that the projects and activities to which information and communications technologies (ICT) resources are committed represent an effective, economic, and efficient use of those resources. This complex problem has no single answer. To determine effective use requires, at the least, a…

The Impact of Project-Based Learning on Pre-Service Teachers' Technology Attitudes and Skills

Science.gov (United States)

Alexander, Curby; Knezek, Gerald; Christensen, Rhonda; Tyler-Wood, Tandra; Bull, Glen

2014-01-01

Researchers in this study looked at the effect of content-specific, technology-rich project-based learning activities on EC-8 pre-service teachers' competencies and skills, as well as pre-service teacher's attitudes toward science, technology, engineering and mathematics (STEM). Researchers employed a quantitative design involving participants in…

PROJECT W-551 INTERIM PRETREATMENT SYSTEM TECHNOLOGY SELECTION SUMMARY DECISION REPORT AND RECOMMENDATION

International Nuclear Information System (INIS)

CONRAD EA

2008-01-01

This report provides the conclusions of the tank farm interim pretreatment technology decision process. It documents the methodology, data, and results of the selection of cross-flow filtration and ion exchange technologies for implementation in project W-551, Interim Pretreatment System. This selection resulted from the evaluation of specific scope criteria using quantitative and qualitative analyses, group workshops, and technical expert personnel

Managing Technology Projects

Science.gov (United States)

Booth, Char

2009-01-01

This will be my first time authoring this column, and I'm delighted to have the opportunity it presents to explore the intersection of library technology and public services. As the recent title of the 2008 Internet Librarian conference indicates, "Beyond Library 2.0: User-Focused Tools and Technologies," the tide of what for several years has…

Oxide fuel fabrication technology development of the FaCT project (1). Overall review of fuel technology development of the FaCT project

International Nuclear Information System (INIS)

Abe, Tomoyuki; Namekawa, Takashi; Tanaka, Kenya

2011-01-01

The FaCT project is in progress in Japan for the commercialization of fast reactor cycle system. The development goal of the fuel in the FaCT project is a low-decontaminated TRU homo-recycling in a closed cycle and extension in average discharge burn-up to 150 GWd/t. Research and development on innovative technologies concerning the short process, remote maintenance and cooling system of automatic fuel production equipments, long life cladding material and control of oxygen potential have been conducted in phase I of the FaCT project. As the result of various test including 600 g batch MOX tests, it is concluded that the short process is available to fuel pellet fabrication of the FaCT project. Although cold mock-up tests on test model of some typical process equipments suggest possibilities of remote maintenance of automatic fuel fabrication equipment, it is concluded that it still needs further efforts to judge the operability of the completely remote fabrication for low-decontaminated TRU fuel. A cold mock-up test on fuel pin assembling equipment show that influence of decay heat of MA can be managed by cooling system. Irradiation tests in BOR-60 indicate that 9Cr-ODS possess the satisfactory in-reactor performance as the long life cladding material if homogeneity of alloy element is adequately controlled. Modification of cladding tube fabrication process to ensure homogeneity and further development of measures to control oxygen potential inside the fuel pin are necessary to reach the burn-up target of the FaCT project. (author)

What's new with nurseries and reforestation projects at the Missoula Technology and Development Center?

Science.gov (United States)

Bob Simonson

2011-01-01

The USDA Forest Service Missoula Technology and Development Center (MTDC) offers technical expertise, technology transfer, and new equipment development to federal, state, and private forest nurseries. Current and recently completed projects at MTDC include a front and mid-mount tractor evaluation, ATV-pulled mechanical tree planter, greenhouse snow remover, freeze...

Residential Energy Efficiency Demonstration: Hawaii and Guam Energy Improvement Technology Demonstration Project

Energy Technology Data Exchange (ETDEWEB)

Earle, L. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Sparn, B. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Rutter, A. [Sustainability Solutions LLC (Guam); Briggs, D. [Naval Base Guam, Santa Rita (Guam)

2014-03-01

In order to meet its energy goals, the Department of Defense (DOD) has partnered with the Department of Energy (DOE) to rapidly demonstrate and deploy cost-effective renewable energy and energy-efficiency technologies. The scope of this project was to demonstrate tools and technologies to reduce energy use in military housing, with particular emphasis on measuring and reducing loads related to consumer electronics (commonly referred to as 'plug loads'), hot water, and whole-house cooling.

The International Science and Technology Center: Scope of activities and scientific projects in the field of nuclear data

International Nuclear Information System (INIS)

Klepatsky, Alexander B.

2002-01-01

The review of the ISTC (The International Science and Technology Center) Programs and activities including Science Project Program, Partner Program, Seminar Program and others is presented. Project funding by technology area, by funding Parties, by CIS (Commonwealth of Independent States) States etc. is demonstrated with emphasis on projects in the field of nuclear data. The ISTC opportunities for international cooperation in the fields of nuclear data measurements, calculation, evaluation and dissemination are discussed. (author)

Advanced Turbine Technology Applications Project (ATTAP) 1993 annual report

Science.gov (United States)

1994-01-01

This report summarizes work performed by AlliedSignal Engines, a unit of AlliedSignal Aerospace Company, during calendar year 1993, toward development and demonstration of structural ceramic technology for automotive gas turbine engines. This work was performed for the U.S. Department of Energy (DOE) under National Aeronautics and Space Administration (NASA) Contract DEN3-335, Advanced Turbine Technology Applications Project (ATFAP). During 1993, the test bed used to demonstrate ceramic technology was changed from the AlliedSignal Engines/Garrett Model AGT101 regenerated gas turbine engine to the Model 331-200(CT) engine. The 331-200(CT) ceramic demonstrator is a fully-developed test platform based on the existing production AlliedSignal 331-200(ER) gas turbine auxiliary power unit (APU), and is well suited to evaluating ceramic turbine blades and nozzles. In addition, commonality of the 331-200(CT) engine with existing gas turbine APU's in commercial service provides the potential for field testing of ceramic components. The 1993 ATTAP activities emphasized design modifications of the 331-200 engine test bed to accommodate ceramic first-stage turbine nozzles and blades, fabrication of the ceramic components, ceramic component proof and rig tests, operational tests of the test bed equipped with the ceramic components, and refinement of critical ceramic design technologies.

Analysis of the Organizational Structure of Enterprises of Technological Basis With Projects Without Incubators

Directory of Open Access Journals (Sweden)

Marcela Gimenes Bera Oshita

2017-03-01

Full Text Available The contingency theory assumes that the structure of the organization involves environment, people, technologies and administrative techniques for achieving the objectives of the company, which must comply with the contingent factors and the environment in which it is inserted. Being that, by the evolution of technology companies must be innovative from an organic structure. Thus, the incubated companies have innovative feature, this way: how is the organizational structure of enterprises of technological basis with projects in incubators? This research aims to asses and classify the organizational structure of enterprises of technological basis with projects in incubators in the State of Paraná. To achieve this goal it carried out a literature review on the contingency theory. Afterwards it was applied the questionnaire with companies incubated in that sought to identify their organizational structure Trough the applied methodology was found that, in General, incubated companies presented some mechanistic designs features with command-based rules and procedures in that only one person takes the decision, which way be the reflection of a technological breakthrough in which companies migrate to a mechanistic designs structure for organic , as well as in the results of Joan Woodward (1958, in which the occurrence of technological advancement, companies use the mechanistic designs structure, changing later to organic.

Accelerating Project and Process Improvement using Advanced Software Simulation Technology: From the Office to the Enterprise

Science.gov (United States)

2010-04-29

Technology: From the Office Larry Smith Software Technology Support Center to the Enterprise 517 SMXS/MXDEA 6022 Fir Avenue Hill AFB, UT 84056 801...2010 to 00-00-2010 4. TITLE AND SUBTITLE Accelerating Project and Process Improvement using Advanced Software Simulation Technology: From the Office to

SIHTI 2. Energy and environmental technology. Yearbook 1994 of the research programme. Project reports

International Nuclear Information System (INIS)

Korhonen, M.; Saviharju, K.

1995-01-01

The SIHTI 2 research programme on energy and environmental technology is concentrating on areas of environmental technology that are vital to Finland or in which Finns can engage in pioneering research. The promotion of product development within the environmental technology industry produces solutions for reducing the emissions of the energy sector. It is also a way of boosting Finland's share of the world market for such technology. The objectives of the programme are to cut down harmful emissions, recycle raw materials, reduce the amount of byproducts and wastes and achieve a greater utilisation of wastes. In additions, an objective is to create basic information about the effects of environmental protection technology for the other national research programmes. The development of internationally comparable research, monitoring and measurement methods creates a basis for wide-ranging international cooperation. The area of research also covers environmental problems connected with energy in the forest and base metal industries as well as the systematic development of life-cycle analyses. The programme will be carried out in 1993 - 1998. As of 1 January 1995 the Technology development Centre TEKES took over the responsibility for energy technology research and development activities, which were previously administered by the Energy Department of the Ministry of Trade and Industry. This yearbook 1994 contains project reports of the research and joint development projects and information about the participating institutions. (orig.)

Choose to Use: Scaffolding for Technology Learning Needs in a Project-Based Learning Environment

Science.gov (United States)

Weimer, Peggy D.

2017-01-01

Project-based learning is one approach used by teachers to meet the challenge of developing more technologically proficient students. This approach, however, requires students to manage a large number of tasks including the mastery of technology. If a student's perception that their capability to perform a task falls below the task's difficulty,…

Human factors and technology environment in multinational project: problems and solutions; Factores humanos y entorno tecnologico en proyectos multinacionales: dificultades y soluciones

Energy Technology Data Exchange (ETDEWEB)

Jardi Besa, X.; Munoz Cervantes, A.

2012-07-01

At the onset of nuclear projects in Spain, there was an import of nuclear technology. In a second phase, there was a transfer of technology. Subsequently, there was an adaptation of the technology. In this evolution, comparable to that of other countries, were involved several countries, overcoming the difficulties of human factors involved. The current nuclear projects multinationals have a new difficulty: the different industrial technological environments. This paper will address the organizational challenges of multinational engineering projects, in the type of project and the human factors of the participating companies.

Financing R&D Projects in Southern Italy: The “Technological Vouchers and Cooperative Research” Program

Directory of Open Access Journals (Sweden)

Gianpaolo Iazzolino

2013-09-01

Full Text Available The paper deals with the evaluation and financing of research and innovation projects. The paper analyzes and discusses the “Technological Vouchers and Cooperative Research” program in the Calabria Region (Southern Italy, as a program for financing R&D projects in a geographical area far behind in development. Three real cases of R&D projects are described. The program was effective as regards the stimulus to realizing R&D activities by Calabrian SMEs and furthermore in relation to the improvement of cooperation between SMEs, research centers, universities and technological laboratories. The weak points of the program mainly regard the evaluation phase that made it impossible to get a feedback useful for policy and for driving future agenda.

Investments in information systems and technology in the healthcare: Project management mediation

Directory of Open Access Journals (Sweden)

Jorge Gomes

2017-03-01

Full Text Available Healthcare organisations must improve their business practices and internal procedures in order to answer the increasing demand of health professionals and the general public for more and better information. Hospitals invest massively in information systems and technology (IS/IT in the hope that these investments will improve healthcare and meet patients’ demands. The main objective of our research is to study how organisational maturity, enhanced by investments in IS/IT, project management and best practices, leads to successful projects in public healthcare organisations. The rational of our model is that organisational maturity has a positive effect on IS/IT project success, and that this success is also positively enhanced by the use of project management practices. We emphasise that this combination of approaches can increase the effectiveness of projects. Furthermore, it can also improve the confidence that the results of investments will meet stakeholders’ expectations.

1990 DOE/SANDIA crystalline photovoltaic technology project review meeting

Energy Technology Data Exchange (ETDEWEB)

Ruby, D.S. (ed.)

1990-07-01

This document serves as the proceedings for the annual project review meeting held by Sandia's Photovoltaic Cell Research Division and Photovoltaic Technology Division. It contains information supplied by each organization making a presentation at the meeting, which was held August 7 through 9, 1990 at the Sheraton Hotel in Albuquerque, New Mexico. Sessions were held to discuss national photovoltaic programs, one-sun crystalline silicon cell research, concentrator silicon cell research, concentrator 3-5 cell research, and concentrating collector development.

TANK FARM REMEDIATION TECHNOLOGY DEVELOPMENT PROJECT AN EXERCISE IN TECHNICAL and REGULATORY COLLABORATION

International Nuclear Information System (INIS)

JARAYSI, M.N.

2007-01-01

The Tank Farm Remediation Technology Development Project at the Hanford Site focuses on waste storage tanks, pipelines and associated ancillary equipment that are part of the C-200 single-shell tank (SST) farm system located in the C Tank Farm. The purpose of the project is to obtain information on the implementation of a variety of closure activities and to answer questions on technical, operational and regulatory issues associated with closure

Application of IT-technologies in visualization of innovation project life-cycle stages during the study of the course "Management of innovation projects"

Science.gov (United States)

Kolychev, V. D.; Prokhorov, I. V.

2017-01-01

The article presents a methodology for the application of IT-technologies in teaching discipline "Management of innovation projects," which helps students to be more competitive and gather the useful skills for their future specialization in high-tech areas. IT-technologies are widely used nowadays in educational and training spheres especially in knowledge-intensive disciplines such as systems analysis, the theory of games, operations research, theory of risks, innovation management etc. For studying such courses it is necessary to combine both mathematical models and information technology approaches for the clear understanding of the investigated object. That is why this article comprises both the framework of research and the IT-tools for investigation in the educational process. Taking into consideration the importance of the IT-system implementation especially for the university we assume to suggest the methods of research in the area of innovation projects with the help of IT-support.

The industrial research project: “Blu-Archeosys – Innovative Technologies and Advanced Systems as Support in Underwater Archaeology”

Directory of Open Access Journals (Sweden)

Salvatore Lorusso

2003-02-01

Full Text Available The reasons of the research about new technologies as support in naval and underwater archaeology or, more generally, in waters archaeology are various and described in this work, where the characteristics of the research project “BLU-ARCHEOSYS – Innovative Technologies and Advanced SYStems as Support in Underwater ARCHaeology” are illustrated. This industrial research project faces problems regarding innovative technologies and instruments in waters archaeology and it comprehends synergic steps and joined works among skilled professionals that have the competences to interpret qualitative and/or quantitative data within an artistic – historical and technical – historical study, also with the involvement of various public and private institutions. The BLUARCHEOSYS project has, in fact, the objective to create technologies that have a reply in underwater archaeology and contemporaneously in other sectors. In particular, starting from the methodological way that spans from the discovery in underwater or subaerial environment to the collocation of the objects in museums, the intent is to support the different methodological stages with specific tools and innovative technologies. The education project, presented to the Ministry with the research one, is articulated in the different branches of artistic-historical character, of the management, normative and operative character, and of the technical-diagnostic-material-preservative character. The professionals will have not only theoretical knowledge about standard and consolidated technologies, but they will be also experts about methodologies, in particular the diagnostic ones, that put in field the innovative tools evaluated in the project, with consequent competitive advantage in the working field, more and more demanding specific sector competences.

High Temperature Syngas Cleanup Technology Scale-up and Demonstration Project

Energy Technology Data Exchange (ETDEWEB)

Gardner, Ben [Research Triangle Inst. (RTI), Research Triangle Park, NC (United States); Turk, Brian [Research Triangle Inst. (RTI), Research Triangle Park, NC (United States); Denton, David [Research Triangle Inst. (RTI), Research Triangle Park, NC (United States); Gupta, Raghubir [Research Triangle Inst. (RTI), Research Triangle Park, NC (United States)

2015-09-30

Gasification is a technology for clean energy conversion of diverse feedstocks into a wide variety of useful products such as chemicals, fertilizers, fuels, electric power, and hydrogen. Existing technologies can be employed to clean the syngas from gasification processes to meet the demands of such applications, but they are expensive to build and operate and consume a significant fraction of overall parasitic energy requirements, thus lowering overall process efficiency. RTI International has developed a warm syngas desulfurization process (WDP) utilizing a transport-bed reactor design and a proprietary attrition-resistant, high-capacity solid sorbent with excellent performance replicated at lab, bench, and pilot scales. Results indicated that WDP technology can improve both efficiency and cost of gasification plants. The WDP technology achieved ~99.9% removal of total sulfur (as either H₂S or COS) from coal-derived syngas at temperatures as high as 600°C and over a wide range of pressures (20-80 bar, pressure independent performance) and sulfur concentrations. Based on the success of these tests, RTI negotiated a cooperative agreement with the U.S. Department of Energy for precommercial testing of this technology at Tampa Electric Company’s Polk Power Station IGCC facility in Tampa, Florida. The project scope also included a sweet water-gas-shift process for hydrogen enrichment and an activated amine process for 90+% total carbon capture. Because the activated amine process provides some additional non-selective sulfur removal, the integration of these processes was expected to reduce overall sulfur in the syngas to sub-ppmv concentrations, suitable for most syngas applications. The overall objective of this project was to mitigate the technical risks associated with the scale up and integration of the WDP and carbon dioxide capture technologies, enabling subsequent commercial-scale demonstration. The warm syngas cleanup pre-commercial test unit

“Freedom from Jobs” or learning to love to labor? Diversity advocacy and working imaginaries in Open Technology Projects

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Christina Dunbar-Hester

2016-12-01

Full Text Available This paper examines imaginaries of work and labor in “open technology” projects (especially open source software and hackerspaces, based on ethnographic research in North America. It zeroes in on “diversity initiatives” within open technology projects. These initiatives are important because they expose many of the assumptions and tensions that surround participatory cultures. On the one hand, these projects and spaces are organized around voluntarism; in theory, everyone who wishes to participate is welcome to do so. On the other hand, diversity initiatives form in order to address the “problem” of imbalance in the ranks of participants. Technology is a unique domain for the discharge of political energies. In collective imagination, it has been vested with the power to initiate change (even as this belief obscures the role of social and economic relations. Multiple ideas circulate about the relationships between diversity in open technology projects and paid labor. This paper argues that in part due to the legacy of technical hobbies as training grounds for technical employment for much of the twentieth century, as documented by historians of radio (Douglas, 1987; Haring, 2006, voluntaristic technology projects are vexed sites for imagining political emancipation. To a large degree, diversity initiatives in open technology projects are consistent with corporate values of diversity as a marketplace value.  At the same time, collectivity formations around technology that incorporate feminist, antiracist, or social justice framings may begin to generate connections between diversity advocacy in tech fields and social justice movements or policy changes in order to effect deep social change. 

Assessing the maturity and re-usability of NASA's Advanced Information System Technology (AIST) Projects

Science.gov (United States)

Little, M. M.; Hines, K.

2016-12-01

Considerable funding has been invested in Earth science information technology (IT) projects by NASA over the past 15 years. While many of these projects succeeded at completing their objectives, rapid improvements in technology and growth in available data could further enhance the capabilities available to the Earth science community. Independent evaluation of these projects has become more and more important. Not only do they qualify the maturity of the work, but they give potential adopters the chance to kick the tires. One approach that has been used is to task Federally Funded Research and Development Corporations (FFRDC) with reviews and paper studies. Another approach involves field testing by third parties. Over the past three years, the AIST Program has tried both. This paper will describe both approaches and lessons learned from the experiences. The audience will be asked for their suggestions as to how to qualify and value these results.

Impact of government and corporate strategy on the performance of technology projects in road construction

NARCIS (Netherlands)

Caerteling, Jasper; Halman, Johannes I.M.; Song, Michael; Song, Michael; Doree, Andries G.

2009-01-01

In this study, we focus on road construction and analyze technology development projects. Based on the business strategy literature and literature on technology policy, we test the relative importance of a firm's strategies and government as a buyer and champion. Our empirical findings stress the

Training project on Radiological Protection in medicine. Use of new technologies

International Nuclear Information System (INIS)

Ruis-Cruces, R.; Perez-Martinez, M.; Pastor Vega, J. M.; Diez de los Rios Delgado, A.

2003-01-01

Radiological protection training addressed to physicians should start during the teaching graduate and postgraduate studies, and a third phase only for those physicians using X rays and radioactive sources in diagnosis and treatment of diseases. To show a training project addressed to the teaching graduate students based on the new technologies, such as web online and interactive CD-ROM. Development of a web-online including information in.pdf (adobe acrobat) format and additional tools (as data bases, videos, news and class meetings, FAQ, tutorials). Moreover, we propose to development an interactive CD-ROM which will be used as a practical tool to complete the obligatory subject on radiological protection in the University of Malaga (Spain). We show the preliminary phase of the project. The web-online is being developed with the Microsoft FrontPage software. The first version of the CR-ROM is being developed in html format. These tools based on new technologies will be a very important support for radiological protection training, which is recommended by International Organizations (EC Report R116 and IAE Action Plan 2002-2006). (Author) 4 refs

Overview of the Photovoltaic Manufacturing Technology (PVMaT) project

International Nuclear Information System (INIS)

Witt, C.E.; Mitchell, R.L.; Mooney, G.D.

1993-08-01

The Photovoltaic Manufacturing Technology (PVMaT) project is a historic government/industry photovoltaic (PV) manufacturing R ampersand D partnership composed of joint efforts between the federal government (through the US Department of Energy) and members of the US PV industry. The project's ultimate goal is to ensure that the US industry retains and extends its world leadership role in the manufacture and commercial development of PV components and systems. PVMaT is designed to do this by helping the US PV industry improve manufacturing processes, accelerate manufacturing cost reductions for PV modules, improve commercial product performance, and lay the groundwork for a substantial scale-up of US-based PV manufacturing capacities. Phase 1 of the project, the problem identification phase, was completed in early 1991. Phase 2, the problem solution phase, which addresses process-specific problems of specific manufacturers, is now underway with an expected duration of 5 years. Phase 3 addresses R ampersand D problems that are relatively common to a number of PV companies or the PV industry as a whole. These ''generic'' problem areas are being addressed through a teamed research approach

A project in support of nuclear technology cooperation

International Nuclear Information System (INIS)

Hwang, Deok Ku; Choi, Pyung Hoon; Lee, Ji Ho

2001-12-01

The results and contents of the project are as follows; Establish strategies of international cooperation in an effort to promote our nation's leading role in international society, to form the foundation for the effective transfer of nuclear technology to developing countries, and to cope with the rapidly changing international nuclear climate. Domestic INIS project has carried out various activities on supporting a decision-making for INIS Secretariat, exchanges of the statistical information between INIS and the country, and technical assistance for domestic end-users using INIS database. Based on the construction of INIS database sent by member states, the data published in the country has been gathered, collected, and inputted to INIS database according to the INIS reference series. Using the INIS output data, it has provided domestic users with searching INIS CD-ROM DB nd INIS online database, INIS SDI service, non-conventional literature delivery services and announce INIS to users. Establish the integrated management system of information resources and to automate business flow and to improve business productivity through efficient information sharing

The 1991 DOE/Sandia Crystalline Photovoltaic Technology Project Review Meeting

Science.gov (United States)

Whipple, M. L.

1991-07-01

This document serves as the proceedings for the manual project review meeting held by Sandia's Photovoltaic Technology Research Division. It contains information supplied by each organization making a presentation at the meeting, which was held July 30 through 31, 1991 at the Sheraton Hotel in Albuquerque, New Mexico. Sessions were held to discuss national photovoltaic programs, one-sun crystalline silicon cell research, concentrator silicon cell research, and concentrating collector development.

Overview of the NASA Environmentally Responsible Aviation Project's Propulsion Technology Portfolio

Science.gov (United States)

Suder, Kenneth L.

2012-01-01

The NASA Environmentally Responsible Aviation (ERA) Project is focused on developing and demonstrating integrated systems technologies to TRL 4-6 by 2020 that enable reduced fuel burn, emissions, and noise for futuristic air vehicles. The specific goals aim to simultaneously reduce fuel burn by 50%, reduce Landing and Take-off Nitrous Oxides emissions by 75% relative to the CAEP 6 guidelines, and reduce cumulative noise by 42 Decibels relative to the Stage 4 guidelines. These goals apply to the integrated vehicle and propulsion system and are based on a reference mission of 3000nm flight of a Boeing 777-200 with GE90 engines. This paper will focus primarily on the ERA propulsion technology portfolio, which consists of advanced combustion, propulsor, and core technologies to enable these integrated air vehicle systems goals. An overview of the ERA propulsion technologies will be described and the status and results to date will be presented.

A research project to develop and evaluate a technical education component on materials technology for orientation to space-age technology

Science.gov (United States)

Jacobs, J. A.

1976-01-01

A project was initiated to develop, implement, and evaluate a prototype component for self-pacing, individualized instruction on basic materials science. Results of this project indicate that systematically developed, self-paced instruction provides an effective means for orienting nontraditional college students and secondary students, especially minorities, to both engineering technology and basic materials science. In addition, students using such a system gain greater chances for mastering subject matter than with conventional modes of instruction.

Factors influencing the societal acceptance of new energy technologies. Meta-analysis of recent European projects

Energy Technology Data Exchange (ETDEWEB)

Poti, B.; Difiore, M. [Consiglio Nazionale delle Ricerche, Rome (Italy); Brohmann, B.; Daniels, A.; Fritsche, U.; Huenecke, K. [Oeko-Institut, Darmstadt (Germany); Heiskanen, E. [National Consumer Research Centre, Helsinki (Finland); Raven, R.P.J.M.; Mourik, R.; Feenstra, C.F.J.; Willemse, R. [ECN Policy Studies, Petten (Netherlands); Hodson, M. [Centre for Sustainable Urban and Regional Futures SURF, University of Salford, Manchester (United Kingdom); Alcantud Torrent, A.; Schaefer, B. [Ecoinstitut Barcelona, Barcelona (Spain); Farkas, B.; Fucsko, J. [Hungarian Environmental Economics Centre MAKK, Budapest (Hungary); Jolivet, E. [IAE Toulouse, Toulouse (France); Maack, M.H.; Matschoss, K. [Icelandic New Energy INE, Reykjavik (Iceland); Oniszk-Poplawska, A. [Institute for Renewable Energy IEO, Warszawa (Poland); Prasad, G. [Energy Research Centre ERC, University of Cape Town, Cape Town (South Africa)

2008-03-15

Within this report an analysis is made of 27 case studies of historical and recent new energy technologies in different European regions and South Africa. The analysis focuses on the societal acceptance in these projects in order to identify determinants of success and failure. A wide diversity of technologies is discussed including hydrogen, CO2 capture and storage, biomass, solar and wind energy technologies.

Next Generation Life Support Project: Development of Advanced Technologies for Human Exploration Missions

Science.gov (United States)

Barta, Daniel J.

2012-01-01

Next Generation Life Support (NGLS) is one of several technology development projects sponsored by the National Aeronautics and Space Administration s Game Changing Development Program. NGLS is developing life support technologies (including water recovery, and space suit life support technologies) needed for humans to live and work productively in space. NGLS has three project tasks: Variable Oxygen Regulator (VOR), Rapid Cycle Amine (RCA) swing bed, and Alternative Water Processing. The selected technologies within each of these areas are focused on increasing affordability, reliability, and vehicle self sufficiency while decreasing mass and enabling long duration exploration. The RCA and VOR tasks are directed at key technology needs for the Portable Life Support System (PLSS) for an Exploration Extravehicular Mobility Unit (EMU), with focus on prototyping and integrated testing. The focus of the Rapid Cycle Amine (RCA) swing-bed ventilation task is to provide integrated carbon dioxide removal and humidity control that can be regenerated in real time during an EVA. The Variable Oxygen Regulator technology will significantly increase the number of pressure settings available to the space suit. Current spacesuit pressure regulators are limited to only two settings while the adjustability of the advanced regulator will be nearly continuous. The Alternative Water Processor efforts will result in the development of a system capable of recycling wastewater from sources expected in future exploration missions, including hygiene and laundry water, based on natural biological processes and membrane-based post treatment. The technologies will support a capability-driven architecture for extending human presence beyond low Earth orbit to potential destinations such as the Moon, near Earth asteroids and Mars.

RESEARCH ON NON-DESTRUCTIVE TESTING TECHNOLOGY IN CONSERVATION REPAIR PROJECT OF ANCESTRAL TEMPLE IN MUKDEN PALACE

Directory of Open Access Journals (Sweden)

J. Yang

2017-08-01

Full Text Available Due to the use of wood and other non-permanent materials, traditional Chinese architecture is one of the most fragile constructions in various heritage objects today. With the increasing emphasis on the protection of cultural relics, the repair project of wooden structure has become more and more important. There are various kinds of destructions, which pose a hidden danger to the overall safety of the ancient buildings, caused not only by time and nature, but also by improper repairs in history or nowadays. Today, the use of digital technology is a basic requirement in the conservation of cultural heritage. Detection technology, especially non-destructive testing technology, could provide more accurate records in capturing detailed physical characteristics of structures such as geometric deformation and invisible damage, as well as prevent a man-made destruction in the process of repair project. This paper aims to interpret with a typical example, Ancestral Temple in Mukden Palace, along with a discussion of how to use the non-destructive testing technology with ground penetrating radar, stress wave, resistograph and so on, in addition to find an appropriate protection method in repair project of traditional Chinese wooden architecture.

Research on Non-Destructive Testing Technology in Conservation Repair Project of Ancestral Temple in Mukden Palace

Science.gov (United States)

Yang, J.; Fu, M.

2017-08-01

Due to the use of wood and other non-permanent materials, traditional Chinese architecture is one of the most fragile constructions in various heritage objects today. With the increasing emphasis on the protection of cultural relics, the repair project of wooden structure has become more and more important. There are various kinds of destructions, which pose a hidden danger to the overall safety of the ancient buildings, caused not only by time and nature, but also by improper repairs in history or nowadays. Today, the use of digital technology is a basic requirement in the conservation of cultural heritage. Detection technology, especially non-destructive testing technology, could provide more accurate records in capturing detailed physical characteristics of structures such as geometric deformation and invisible damage, as well as prevent a man-made destruction in the process of repair project. This paper aims to interpret with a typical example, Ancestral Temple in Mukden Palace, along with a discussion of how to use the non-destructive testing technology with ground penetrating radar, stress wave, resistograph and so on, in addition to find an appropriate protection method in repair project of traditional Chinese wooden architecture.

WEB 2.0 SERVICES AS A TECHNOLOGICAL FOUNDATION OF A NETWORK PROJECT

Directory of Open Access Journals (Sweden)

Tatiana Ivanovna Kanyanina

2015-02-01

Full Text Available In the light of the requirements of the federal state educational standard increases the value of the network design based on the use of Web 2.0 services. The article outlines the range of technological challenges faced by the developer of the network project, such as the choice of the network platform of the project, design tools and tools for project results placement, project coordination and organization of communication lines, the choice of instruments for the promotion of the project on the Internet. The main attention is focused on the examples of network services that address these challenges, and describe their features. The authors rely on the specific network projects implemented in Nizhny Novgorod region. The paper analyzes the possible project’s network sites (network environment. The article gives a general description of each environment, marks its distinctive features, advantages and disadvantages. The article presents project tasks’ examples, designed on the basis of the variety of Web 2.0 services that functionally meet the requirements of a particular task, examples of services to represent the project products and to summarize its results. Attention is paid to the organization of the lines of communication of the project participants and organizers and to the role of network services in the project promotion on the Internet.