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Sample records for technologies pat directorate

  1. Mr. Pat McDonald, Director of "Key Business Technologies", Department of Trade and Industry, United Kingdom

    CERN Document Server

    Maximilien Brice

    2002-01-01

    Photos 01,02: Mr Pat McDonald, Director of "Key Business Technologies", Department of Trade and Industry, UK (third from left, front) in front of the ATLAS End-Cap Toroid vacuum vessel in the ATLAS assembly hall with, from left to right, Fred Wickens, Chris Jones, Peter Fletcher, Ray Browne, Neil Geddes, Jim Fleming, Anne Trefethen, Jim Wilson, Edwin Towndrow, Sharon Bonfield, Guy Rickett, Ken Smith, Peter Jenni. Photo 03: Mr Pat McDonald, Director of "Key Business Technologies", Department of Trade and Industry, UK (fifth from left) visiting ATLAS assembly hall with, from left to right, Jim Wilson, Peter Jenni, Ken Smith, Edwin Towndrow, Ray Brown, Chris Jones, Neil Geddes, Sharon Bonfield, Anne Trefethen, Jim Fleming, Fred Wickens. Photo 04: Mr Pat McDonald, Director of "Key Business Technologies", Department of Trade and Industry, UK (fourth from right) in front of the ATLAS Barrel Toroid coil casing in the ATLAS assembly hall with, from left to right, Peter Jenni, Jim Wilson, Guy Rickett, Anne Trefethen, ...

  2. Process analytical technology (PAT) for biopharmaceuticals

    DEFF Research Database (Denmark)

    Glassey, Jarka; Gernaey, Krist; Clemens, Christoph

    2011-01-01

    Process analytical technology (PAT), the regulatory initiative for building in quality to pharmaceutical manufacturing, has a great potential for improving biopharmaceutical production. The recommended analytical tools for building in quality, multivariate data analysis, mechanistic modeling, novel...... models for interpretation of systems biology data and new sensor technologies for cellular states, are instrumental in exploiting this potential. Industrial biopharmaceutical production has gradually become dependent on large-scale processes using sensitive mammalian cell cultures. This further...

  3. Designing Robust Process Analytical Technology (PAT) Systems for Crystallization Processes: A Potassium Dichromate Crystallization Case Study

    DEFF Research Database (Denmark)

    Abdul Samad, Noor Asma Fazli Bin; Sin, Gürkan

    2013-01-01

    The objective of this study is to test and validate a Process Analytical Technology (PAT) system design on a potassium dichromate crystallization process in the presence of input uncertainties using uncertainty and sensitivity analysis. To this end a systematic framework for managing uncertainties...... in the nucleation and crystal growth parameters affect the product-process performances (e.g. crystal size distribution (CSD)). Analysis of the proposed PAT system design (closedloop), on the other hand, shows that the effect of the input uncertainties on the outputs (product quality) is minimized, and the target...

  4. A Robust Process Analytical Technology (PAT) System Design for Crystallization Processes

    DEFF Research Database (Denmark)

    Abdul Samad, Noor Asma Fazli Bin; Sin, Gürkan; Gernaey, Krist

    2013-01-01

    for generation of the supersaturation setpoint for a supersaturation controller, a tool for design of a process monitoring and control system (also called Process Analytical Technology (PAT) system) as well as a tool for performing uncertainty and sensitivity analysis of the PAT system design. The uncertainty......A generic computer-aided framework for systematic design of a process monitoring and control system for crystallization processes has been developed to study various aspects of crystallization operations. The design framework contains a generic multidimensional modelling framework, a tool...... crystallization process to achieve the target crystal size distribution (CSD) in the presence of parametric uncertainties....

  5. Designing Robust Process Analytical Technology (PAT) Systems for Crystallization Processes: A Potassium Dichromate Crystallization Case Study

    DEFF Research Database (Denmark)

    Abdul Samad, Noor Asma Fazli Bin; Sin, Gürkan

    2013-01-01

    The objective of this study is to test and validate a Process Analytical Technology (PAT) system design on a potassium dichromate crystallization process in the presence of input uncertainties using uncertainty and sensitivity analysis. To this end a systematic framework for managing uncertaintie...

  6. Development of Process Analytical Technology (PAT) methods for controlled release pellet coating.

    Science.gov (United States)

    Avalle, P; Pollitt, M J; Bradley, K; Cooper, B; Pearce, G; Djemai, A; Fitzpatrick, S

    2014-07-01

    This work focused on the control of the manufacturing process for a controlled release (CR) pellet product, within a Quality by Design (QbD) framework. The manufacturing process was Wurster coating: firstly layering active pharmaceutical ingredient (API) onto sugar pellet cores and secondly a controlled release (CR) coating. For each of these two steps, development of a Process Analytical Technology (PAT) method is discussed and also a novel application of automated microscopy as the reference method. Ultimately, PAT methods should link to product performance and the two key Critical Quality Attributes (CQAs) for this CR product are assay and release rate, linked to the API and CR coating steps respectively. In this work, the link between near infra-red (NIR) spectra and those attributes was explored by chemometrics over the course of the coating process in a pilot scale industrial environment. Correlations were built between the NIR spectra and coating weight (for API amount), CR coating thickness and dissolution performance. These correlations allow the coating process to be monitored at-line and so better control of the product performance in line with QbD requirements. Copyright © 2014 Elsevier B.V. All rights reserved.

  7. Process analytical technology (PAT) for biopharmaceutical products: Part II. Concepts and applications.

    Science.gov (United States)

    Read, E K; Shah, R B; Riley, B S; Park, J T; Brorson, K A; Rathore, A S

    2010-02-01

    Implementing real-time product quality control meets one or both of the key goals outlined in FDA's PAT guidance: "variability is managed by the process" and "product quality attributes can be accurately and reliably predicted over the design space established for materials used, process parameters, manufacturing, environmental, and other conditions." The first part of the paper presented an overview of PAT concepts and applications in the areas of upstream and downstream processing. In this second part, we present principles and case studies to illustrate implementation of PAT for drug product manufacturing, rapid microbiology, and chemometrics. We further present our thoughts on how PAT will be applied to biotech processes going forward. The role of PAT as an enabling component of the Quality by Design framework is highlighted. Integration of PAT with the principles stated in the ICH Q8, Q9, and Q10 guidance documents is also discussed.

  8. Assessment of Recent Process Analytical Technology (PAT) Trends: A Multiauthor Review

    DEFF Research Database (Denmark)

    Simon, Levente L.; Pataki, Hajnalka; Marosi, György

    2015-01-01

    in industrial laboratories and in manufacture e.g. at GSK, AstraZeneca and Roche. Furthermore, the paper discusses the PAT paradigm from the regulatory science perspective. Given the multidisciplinary nature of PAT, such an endeavour would be almost impossible for a single author, so the concept...

  9. 2016 Science Mission Directorate Technology Highlights

    Science.gov (United States)

    Seablom, Michael S.

    2017-01-01

    The role of the Science Mission Directorate (SMD) is to enable NASA to achieve its science goals in the context of the nation's science agenda. SMD's strategic decisions regarding future missions and scientific pursuits are guided by agency goals, input from the science community including the recommendations set forth in the National Research Council (NRC) decadal surveys and a commitment to preserve a balanced program across the major science disciplines. Toward this end, each of the four SMD science divisions -- Heliophysics, Earth Science, Planetary Science, and Astrophysics -- develops fundamental science questions upon which to base future research and mission programs.

  10. Space Technology Mission Directorate: Game Changing Development

    Science.gov (United States)

    Gaddis, Stephen W.

    2015-01-01

    NASA and the aerospace community have deep roots in manufacturing technology and innovation. Through it's Game Changing Development Program and the Advanced Manufacturing Technology Project NASA develops and matures innovative, low-cost manufacturing processes and products. Launch vehicle propulsion systems are a particular area of interest since they typically comprise a large percentage of the total vehicle cost and development schedule. NASA is currently working to develop and utilize emerging technologies such as additive manufacturing (i.e. 3D printing) and computational materials and processing tools that could dramatically improve affordability, capability, and reduce schedule for rocket propulsion hardware.

  11. Flight Opportunities: Space Technology Mission Directorate

    Science.gov (United States)

    Van Dijk, Alexander

    2016-01-01

    Flight Opportunities enables maturation of new space technologies by funding access to commercially available space-relevant test environments. The program also supports capability development in the commercial suborbital and orbital small satellite launcher markets.

  12. Implementing PAT with Standards

    Science.gov (United States)

    Chandramohan, Laakshmana Sabari; Doolla, Suryanarayana; Khaparde, S. A.

    2016-02-01

    Perform Achieve Trade (PAT) is a market-based incentive mechanism to promote energy efficiency. The purpose of this work is to address the challenges inherent to inconsistent representation of business processes, and interoperability issues in PAT like cap-and-trade mechanisms especially when scaled. Studies by various agencies have highlighted that as the mechanism evolves including more industrial sectors and industries in its ambit, implementation will become more challenging. This paper analyses the major needs of PAT (namely tracking, monitoring, auditing & verifying energy-saving reports, and providing technical support & guidance to stakeholders); and how the aforesaid reasons affect them. Though current technologies can handle these challenges to an extent, standardization activities for implementation have been scanty for PAT and this work attempts to evolve them. The inconsistent modification of business processes, rules, and procedures across stakeholders, and interoperability among heterogeneous systems are addressed. This paper proposes the adoption of specifically two standards into PAT, namely Business Process Model and Notation for maintaining consistency in business process modelling, and Common Information Model (IEC 61970, 61968, 62325 combined) for information exchange. Detailed architecture and organization of these adoptions are reported. The work can be used by PAT implementing agencies, stakeholders, and standardization bodies.

  13. Information technology and the board of directors.

    Science.gov (United States)

    Nolan, Richard; McFarlan, F Warren

    2005-10-01

    Ever since the Y2K scare, boards have grown increasingly nervous about corporate dependence on information technology. Since then, computer crashes, denial of service attacks, competitive pressures, and the need to automate compliance with government regulations have heightened board sensitivity to IT risk. Unfortunately, most boards remain largely in the dark when it comes to IT spending and strategy, despite the fact that corporate information assets can account for more than 50% of capital spending. A lack of board oversight for IT activities is dangerous, the authors say. It puts firms at risk in the same way that failing to audit their books would. Companies that have established board-level IT governance committees are better able to control IT project costs and carve out competitive advantage. But there is no one-size-fits-all model for board supervision of a company's IT operations. The correct approach depends on what strategic "mode" a company is in whether its operations are extremely dependent on IT or not, and whether or not it relies heavily on keeping up with the latest technologies. This article spells out the conditions under which boards need to change their level of involvement in IT decisions, explaining how members can recognize their firms' IT risks and decide whether they should pursue more aggressive IT governance. The authors delineate what an IT governance committee should look like in terms of charter, membership, duties, and overall agenda. They also offer recommendations for developing IT policies that take into account an organization's operational and strategic needs and suggest what to do when those needs change. Given the dizzying pace of change in the world of IT, boards can't afford to ignore the state of their IT systems and capabilities. Appropriate board governance can go a long way toward helping a company avoid unnecessary risk and improve its competitive position.

  14. Teacher's PAT?

    DEFF Research Database (Denmark)

    Vanhuysse, Pieter; Sulitzeanu-Kenan, Raanan

    2009-01-01

    This article aims to contribute to current theoretical debates about political power and agency relationships in education and other public sector settings. In a recent clarion call for a major redirection of political principal-agent theories (PAT), Terry Moe has argued that standard information...... implications for our understanding of the political power of public school teachers and bureaucrats more generally....

  15. PAT tools for fermentation processes

    DEFF Research Database (Denmark)

    Gernaey, Krist; Bolic, Andrijana; Svanholm, Bent

    2012-01-01

    The publication of the Process Analytical Technology (PAT) guidance has been one of the most important milestones for pharmaceutical production during the past ten years. The ideas outlined in the PAT guidance are also applied in other industries, for example the fermentation industry. Process...... knowledge is central in PAT projects. This manuscript therefore gives a brief overview of a number of PAT tools for collecting process knowledge on fermentation processes: on-line sensors, mechanistic models and small-scale equipment for high-throughput experimentation. The manuscript ends with a short...

  16. PAT tools for fermentation processes

    DEFF Research Database (Denmark)

    Gernaey, Krist; Bolic, Andrijana; Svanholm, Bent

    2012-01-01

    The publication of the Process Analytical Technology (PAT) guidance has been one of the most important milestones for pharmaceutical production during the past ten years. The ideas outlined in the PAT guidance are also applied in other industries, for example the fermentation industry. Process...... knowledge is central in PAT projects. This manuscript therefore gives a brief overview of a number of PAT tools for collecting process knowledge on fermentation processes: on-line sensors, mechanistic models and small-scale equipment for high-throughput experimentation. The manuscript ends with a short...

  17. PAT tools for fermentation processes

    DEFF Research Database (Denmark)

    Gernaey, Krist

    The publication of the Process Analytical Technology (PAT) guidance has been one of the most important milestones for pharmaceutical production during the past ten years. The ideas outlined in the PAT guidance are also applied in other industries, for example the fermentation industry. Process...... knowledge is central in PAT projects. This presentation therefore gives a brief overview of a number of PAT tools for collecting process knowledge on fermentation processes: - On-line sensors, where for example spectroscopic measurements are increasingly applied - Mechanistic models, which can be used...

  18. 75 FR 33631 - Science and Technology (S&T) Directorate; Agency Information Collection Activities: Submission...

    Science.gov (United States)

    2010-06-14

    ... SECURITY Science and Technology (S&T) Directorate; Agency Information Collection Activities: Submission for Review; Information Collection Request for the Department of Homeland Security (DHS) Science and... Security's (DHS's) Science and Technology (S&T) Directorate to provide information, resources...

  19. Strategic framework for education and training in Quality by Design (QbD) and process analytical technology (PAT).

    Science.gov (United States)

    de Matas, Marcel; De Beer, Thomas; Folestad, Staffan; Ketolainen, Jarkko; Lindén, Hans; Lopes, João Almeida; Oostra, Wim; Weimer, Marco; Öhrngren, Per; Rantanen, Jukka

    2016-07-30

    The regulatory and technical landscape of the pharmaceutical field is rapidly evolving from one focused predominantly on development of small molecules, using well established manufacturing technologies towards an environment in which biologicals and complex modalities are being developed using advanced science and technology coupled with the application of modern Quality by Design (QbD) principles. In order that Europe keeps pace with these changes and sustains its position as major player in the development and commercialization of medicines, it is essential that measures are put in place to maintain a highly skilled workforce. A number of challenges however exist to equipping academic, industrial and health agency staff with the requisite knowledge, skills and experience to develop the next generation of medicines. In this regard, the EUFEPS QbD and PAT Sciences Network has proposed a structured framework for education, training and continued professional development, which comprises a number of pillars covering the fundamental principles of modern pharmaceutical development including the underpinning aspects of science, engineering and technology innovation. The framework is not prescriptive and is not aimed at describing specific course content in detail. It should however be used as a point of reference for those institutions delivering pharmaceutical based educational courses, to ensure that the necessary skills, knowledge and experience for successful pharmaceutical development are maintained. A positive start has been made and a number of examples of formal higher education courses and short training programs containing elements of this framework have been described. The ultimate vision for this framework however, is to see widespread adoption and proliferation of this curriculum with it forming the backbone of QbD and PAT science based skills development.

  20. Introducing process analytical technology (PAT) in filamentous cultivation process development: comparison of advanced online sensors for biomass measurement

    DEFF Research Database (Denmark)

    Rønnest, Nanna Petersen; Stocks, Stuart M.; Eliasson Lantz, Anna

    2011-01-01

    The recent process analytical technology (PAT) initiative has put an increased focus on online sensors to generate process-relevant information in real time. Specifically for fermentation, however, introduction of online sensors is often far from straightforward, and online measurement of biomass...... is one of the best examples. The purpose of this study was therefore to compare the performance of various online biomass sensors, and secondly to demonstrate their use in early development of a filamentous cultivation process. Eight Streptomyces coelicolor fed-batch cultivations were run as part...... of process development in which the pH, the feeding strategy, and the medium composition were varied. The cultivations were monitored in situ using multi-wavelength fluorescence (MWF) spectroscopy, scanning dielectric (DE) spectroscopy, and turbidity measurements. In addition, we logged all of the classical...

  1. A Process Analytical Technology (PAT) approach to control a new API manufacturing process: development, validation and implementation.

    Science.gov (United States)

    Schaefer, Cédric; Clicq, David; Lecomte, Clémence; Merschaert, Alain; Norrant, Edith; Fotiadu, Frédéric

    2014-03-01

    Pharmaceutical companies are progressively adopting and introducing Process Analytical Technology (PAT) and Quality-by-Design (QbD) concepts promoted by the regulatory agencies, aiming the building of the quality directly into the product by combining thorough scientific understanding and quality risk management. An analytical method based on near infrared (NIR) spectroscopy was developed as a PAT tool to control on-line an API (active pharmaceutical ingredient) manufacturing crystallization step during which the API and residual solvent contents need to be precisely determined to reach the predefined seeding point. An original methodology based on the QbD principles was designed to conduct the development and validation of the NIR method and to ensure that it is fitted for its intended use. On this basis, Partial least squares (PLS) models were developed and optimized using chemometrics methods. The method was fully validated according to the ICH Q2(R1) guideline and using the accuracy profile approach. The dosing ranges were evaluated to 9.0-12.0% w/w for the API and 0.18-1.50% w/w for the residual methanol. As by nature the variability of the sampling method and the reference method are included in the variability obtained for the NIR method during the validation phase, a real-time process monitoring exercise was performed to prove its fit for purpose. The implementation of this in-process control (IPC) method on the industrial plant from the launch of the new API synthesis process will enable automatic control of the final crystallization step in order to ensure a predefined quality level of the API. In addition, several valuable benefits are expected including reduction of the process time, suppression of a rather difficult sampling and tedious off-line analyses.

  2. The development and application of mid-infrared spectroscopy as a process analytical technology (PAT) tool for cell culture applications

    OpenAIRE

    Foley, Roisin

    2013-01-01

    The objective of this thesis was to investigate the use of mid-infrared spectroscopy(MIR) as a PAT tool in bioprocessing. This was achieved through the development of chemometric models from MIR spectroscopic data. Models were applied to both upstream and downstream bioprocess steps to evaluate the potential of MIR as a PAT tool in each scenario.The first study included a preliminary examination of 8 typical components found in a mammalian cell culture medium. A multivariate limit of detec...

  3. Multi-parameter flow cytometry as a process analytical technology (PAT) approach for the assessment of bacterial ghost production.

    Science.gov (United States)

    Langemann, Timo; Mayr, Ulrike Beate; Meitz, Andrea; Lubitz, Werner; Herwig, Christoph

    2016-01-01

    Flow cytometry (FCM) is a tool for the analysis of single-cell properties in a cell suspension. In this contribution, we present an improved FCM method for the assessment of E-lysis in Enterobacteriaceae. The result of the E-lysis process is empty bacterial envelopes-called bacterial ghosts (BGs)-that constitute potential products in the pharmaceutical field. BGs have reduced light scattering properties when compared with intact cells. In combination with viability information obtained from staining samples with the membrane potential-sensitive fluorescent dye bis-(1,3-dibutylarbituric acid) trimethine oxonol (DiBAC4(3)), the presented method allows to differentiate between populations of viable cells, dead cells, and BGs. Using a second fluorescent dye RH414 as a membrane marker, non-cellular background was excluded from the data which greatly improved the quality of the results. Using true volumetric absolute counting, the FCM data correlated well with cell count data obtained from colony-forming units (CFU) for viable populations. Applicability of the method to several Enterobacteriaceae (different Escherichia coli strains, Salmonella typhimurium, Shigella flexneri 2a) could be shown. The method was validated as a resilient process analytical technology (PAT) tool for the assessment of E-lysis and for particle counting during 20-l batch processes for the production of Escherichia coli Nissle 1917 BGs.

  4. Introducing process analytical technology (PAT) in filamentous cultivation process development: comparison of advanced online sensors for biomass measurement.

    Science.gov (United States)

    Rønnest, Nanna Petersen; Stocks, Stuart M; Eliasson Lantz, Anna; Gernaey, Krist V

    2011-10-01

    The recent process analytical technology (PAT) initiative has put an increased focus on online sensors to generate process-relevant information in real time. Specifically for fermentation, however, introduction of online sensors is often far from straightforward, and online measurement of biomass is one of the best examples. The purpose of this study was therefore to compare the performance of various online biomass sensors, and secondly to demonstrate their use in early development of a filamentous cultivation process. Eight Streptomyces coelicolor fed-batch cultivations were run as part of process development in which the pH, the feeding strategy, and the medium composition were varied. The cultivations were monitored in situ using multi-wavelength fluorescence (MWF) spectroscopy, scanning dielectric (DE) spectroscopy, and turbidity measurements. In addition, we logged all of the classical cultivation data, such as the carbon dioxide evolution rate (CER) and the concentration of dissolved oxygen. Prediction models for the biomass concentrations were estimated on the basis of the individual sensors and on combinations of the sensors. The results showed that the more advanced sensors based on MWF and scanning DE spectroscopy did not offer any advantages over the simpler sensors based on dual frequency DE spectroscopy, turbidity, and CER measurements for prediction of biomass concentration. By combining CER, DE spectroscopy, and turbidity measurements, the prediction error was reduced to 1.5 g/l, corresponding to 6% of the covered biomass range. Moreover, by using multiple sensors it was possible to check the quality of the individual predictions and switch between the sensors in real time.

  5. Space directorate research and technology accomplishments for fiscal year 1987

    Science.gov (United States)

    Avery, Don E.

    1988-01-01

    The major accomplishments and test highlights of the Space Directorate of NASA Langley Research Center for FY87 are presented. Accomplishments and test highlights are listed by Division and Branch. This information should be useful in coordinating programs with government organizations, universities, and industry in areas of mutual interest.

  6. Introducing uncertainty analysis of nucleation and crystal growth models in Process Analytical Technology (PAT) system design of crystallization processes.

    Science.gov (United States)

    Samad, Noor Asma Fazli Abdul; Sin, Gürkan; Gernaey, Krist V; Gani, Rafiqul

    2013-11-01

    This paper presents the application of uncertainty and sensitivity analysis as part of a systematic model-based process monitoring and control (PAT) system design framework for crystallization processes. For the uncertainty analysis, the Monte Carlo procedure is used to propagate input uncertainty, while for sensitivity analysis, global methods including the standardized regression coefficients (SRC) and Morris screening are used to identify the most significant parameters. The potassium dihydrogen phosphate (KDP) crystallization process is used as a case study, both in open-loop and closed-loop operation. In the uncertainty analysis, the impact on the predicted output of uncertain parameters related to the nucleation and the crystal growth model has been investigated for both a one- and two-dimensional crystal size distribution (CSD). The open-loop results show that the input uncertainties lead to significant uncertainties on the CSD, with appearance of a secondary peak due to secondary nucleation for both cases. The sensitivity analysis indicated that the most important parameters affecting the CSDs are nucleation order and growth order constants. In the proposed PAT system design (closed-loop), the target CSD variability was successfully reduced compared to the open-loop case, also when considering uncertainty in nucleation and crystal growth model parameters. The latter forms a strong indication of the robustness of the proposed PAT system design in achieving the target CSD and encourages its transfer to full-scale implementation.

  7. School Nutrition Directors' Perceptions of Technology Use in School Nutrition Programs

    Science.gov (United States)

    Pratt, Peggy; Bednar, Carolyn; Kwon, Junehee

    2012-01-01

    Purpose/Objectives: This study investigated the types of technology/software currently used by Southwest Region school nutrition directors (SNDs) and assessed their perceptions of barriers to purchasing new technology/software. In addition, the importance of future technology/software acquisitions in meeting school nutrition program (SNP) goals…

  8. Introducing uncertainty analysis of nucleation and crystal growth models in Process Analytical Technology (PAT) system design of crystallization processes

    DEFF Research Database (Denmark)

    Abdul Samad, Noor Asma Fazli Bin; Sin, Gürkan; Gernaey, Krist

    2013-01-01

    This paper presents the application of uncertainty and sensitivity analysis as part of a systematic modelbased process monitoring and control (PAT) system design framework for crystallization processes. For the uncertainty analysis, the Monte Carlo procedure is used to propagate input uncertainty......, while for sensitivity analysis, global methods including the standardized regression coefficients (SRC) and Morris screening are used to identify the most significant parameters. The potassium dihydrogen phosphate (KDP) crystallization process is used as a case study, both in open-loop and closed...

  9. Space Technology Mission Directorate Game Changing Development Program FY2015 Annual Program Review: Advanced Manufacturing Technology

    Science.gov (United States)

    Vickers, John; Fikes, John

    2015-01-01

    The Advance Manufacturing Technology (AMT) Project supports multiple activities within the Administration's National Manufacturing Initiative. A key component of the Initiative is the Advanced Manufacturing National Program Office (AMNPO), which includes participation from all federal agencies involved in U.S. manufacturing. In support of the AMNPO the AMT Project supports building and Growing the National Network for Manufacturing Innovation through a public-private partnership designed to help the industrial community accelerate manufacturing innovation. Integration with other projects/programs and partnerships: STMD (Space Technology Mission Directorate), HEOMD, other Centers; Industry, Academia; OGA's (e.g., DOD, DOE, DOC, USDA, NASA, NSF); Office of Science and Technology Policy, NIST Advanced Manufacturing Program Office; Generate insight within NASA and cross-agency for technology development priorities and investments. Technology Infusion Plan: PC; Potential customer infusion (TDM, HEOMD, SMD, OGA, Industry); Leverage; Collaborate with other Agencies, Industry and Academia; NASA roadmap. Initiatives include: Advanced Near Net Shape Technology Integrally Stiffened Cylinder Process Development (launch vehicles, sounding rockets); Materials Genome; Low Cost Upper Stage-Class Propulsion; Additive Construction with Mobile Emplacement (ACME); National Center for Advanced Manufacturing.

  10. 78 FR 3019 - Privacy Act of 1974; Science & Technology Directorate-001 Research, Development, Test, and...

    Science.gov (United States)

    2013-01-15

    ... of, or during the conduct of, Science & Technology-funded research, development, test, and evaluation...) proposes to update and reissue a current DHS system of records titled, ``DHS/S&T-001 Research, Development...) Science & Technology Directorate's (S&T) mission is to conduct research, development, testing, and...

  11. 75 FR 53705 - Science and Technology (S&T) Directorate; Agency Information Collection Activities: Submission...

    Science.gov (United States)

    2010-09-01

    ...-53706] [FR Doc No: 2010-21783] DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2010-0073] Science and Technology (S&T) Directorate; Agency Information Collection Activities: Submission for Review; Information Collection Request for the Department of Homeland Security (DHS) Science and Technology Protected...

  12. 75 FR 53706 - Science and Technology (S&T) Directorate: Agency Information Collection Activities: Submission...

    Science.gov (United States)

    2010-09-01

    ...-53707] [FR Doc No: 2010-21786] DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2010-0072] Science and Technology (S&T) Directorate: Agency Information Collection Activities: Submission for Review; Information Collection Request for the Department of Homeland Security (DHS) Science and Technology TechSolutions...

  13. Quality-by-Design (QbD): An integrated process analytical technology (PAT) approach for a dynamic pharmaceutical co-precipitation process characterization and process design space development.

    Science.gov (United States)

    Wu, Huiquan; White, Maury; Khan, Mansoor A

    2011-02-28

    The aim of this work was to develop an integrated process analytical technology (PAT) approach for a dynamic pharmaceutical co-precipitation process characterization and design space development. A dynamic co-precipitation process by gradually introducing water to the ternary system of naproxen-Eudragit L100-alcohol was monitored at real-time in situ via Lasentec FBRM and PVM. 3D map of count-time-chord length revealed three distinguishable process stages: incubation, transition, and steady-state. The effects of high risk process variables (slurry temperature, stirring rate, and water addition rate) on both derived co-precipitation process rates and final chord-length-distribution were evaluated systematically using a 3(3) full factorial design. Critical process variables were identified via ANOVA for both transition and steady state. General linear models (GLM) were then used for parameter estimation for each critical variable. Clear trends about effects of each critical variable during transition and steady state were found by GLM and were interpreted using fundamental process principles and Nyvlt's transfer model. Neural network models were able to link process variables with response variables at transition and steady state with R(2) of 0.88-0.98. PVM images evidenced nucleation and crystal growth. Contour plots illustrated design space via critical process variables' ranges. It demonstrated the utility of integrated PAT approach for QbD development. Published by Elsevier B.V.

  14. An integrated process analytical technology (PAT) approach to monitoring the effect of supercooling on lyophilization product and process parameters of model monoclonal antibody formulations.

    Science.gov (United States)

    Awotwe Otoo, David; Agarabi, Cyrus; Khan, Mansoor A

    2014-07-01

    The aim of the present study was to apply an integrated process analytical technology (PAT) approach to control and monitor the effect of the degree of supercooling on critical process and product parameters of a lyophilization cycle. Two concentrations of a mAb formulation were used as models for lyophilization. ControLyo™ technology was applied to control the onset of ice nucleation, whereas tunable diode laser absorption spectroscopy (TDLAS) was utilized as a noninvasive tool for the inline monitoring of the water vapor concentration and vapor flow velocity in the spool during primary drying. The instantaneous measurements were then used to determine the effect of the degree of supercooling on critical process and product parameters. Controlled nucleation resulted in uniform nucleation at lower degrees of supercooling for both formulations, higher sublimation rates, lower mass transfer resistance, lower product temperatures at the sublimation interface, and shorter primary drying times compared with the conventional shelf-ramped freezing. Controlled nucleation also resulted in lyophilized cakes with more elegant and porous structure with no visible collapse or shrinkage, lower specific surface area, and shorter reconstitution times compared with the uncontrolled nucleation. Uncontrolled nucleation however resulted in lyophilized cakes with relatively lower residual moisture contents compared with controlled nucleation. TDLAS proved to be an efficient tool to determine the endpoint of primary drying. There was good agreement between data obtained from TDLAS-based measurements and SMART™ technology. ControLyo™ technology and TDLAS showed great potential as PAT tools to achieve enhanced process monitoring and control during lyophilization cycles. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.

  15. Assistant director of intramural sports and technology recognized for innovative contributions

    OpenAIRE

    Kropff, Catherine L.

    2009-01-01

    Jennifer Rezac, assistant director of intramural sports and technology at Virginia Tech, was recognized at the National Intramural-Recreational Sports Association (NIRSA) Annual Conference in Charlotte, N.C., in April for her contributions to the Virginia Tech Recreational Sports department.

  16. Virginia Bioinformatics Institute names Otto Folkerts associate director of technology development

    OpenAIRE

    2005-01-01

    The Virginia Bioinformatics Institute (VBI) at Virginia Tech has named Otto Folkerts as the institute's associate director of technology development. In his new position, Folkerts will serve as a member of the senior management team with direct responsibility for the development of new business initiatives as well as expanding the institute's current commercial activities.

  17. Mobile Technology and Health Care, From NIH Director Dr. Francis S. Collins | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... version of this page please turn Javascript on. Mobile Technology and Health Care, From NIH Director Dr. Francis S. ... Contents Mobile health, or mHealth for short, uses mobile technologies for health research and healthcare delivery. At last ...

  18. Center Director Bridges visits Disability Awareness and Action working Group Technology Fair

    Science.gov (United States)

    1999-01-01

    Center Director Roy Bridges stops to talk to one of the vendors at the Disability Awareness and Action Working Group (DAAWG) Technology Fair being held Oct. 20-21 at Kennedy Space Center. With him at the far left is Sterling Walker, director of Engineering Development at KSC and chairman of DAAWG, and Nancie Strott, a multi-media specialist with Dynacs and chairperson of the Fair; at the right is Carol Cavanaugh, with KSC Public Services. The Fair is highlighting vendors demonstrating mobility, hearing, vision and silent disability assistive technology. The purpose is to create an awareness of the types of technology currently available to assist people with various disabilities in the workplace. The theme is that of this year's National Disability Employment Awareness Month, 'Opening Doors to Ability.' Some of the vendors participating are Canine Companions for Independence, Goodwill Industries, Accessible Structures, Division of Blind Services, Space Coast Center for Independent Living, KSC Fitness Center and Delaware North Parks Services.

  19. March 2008 - ITER Organization Director-General K.Ikeda and Deputy Director-General N. Holtkamp, visiting the ATLAS cavern with Spokesperson P. Jenni, Accelerators Technology Department Head P. Lebrun and LHC Mangnets Group Leader L. Rossi.

    CERN Multimedia

    Claudia Marcelloni

    2008-01-01

    March 2008 - ITER Organization Director-General K.Ikeda and Deputy Director-General N. Holtkamp, visiting the ATLAS cavern with Spokesperson P. Jenni, Accelerators Technology Department Head P. Lebrun and LHC Mangnets Group Leader L. Rossi.

  20. Phoenix well director{sup R}-rotary steerable tool technology

    Energy Technology Data Exchange (ETDEWEB)

    Buker, M. [Phoenix Technology Services Ltd., Calgary, AB (Canada)

    2000-06-01

    This paper presented a new technology developed to replace steerable mud motor drilling used in horizontal or directional drilling. The rotary steerable tool (RTS) called the Well Director{sup R} Automatic Directional Drilling System will be marketed and serviced by Phoenix Technology Services Ltd. RTS technology is more efficient and is becoming an economically viable and good alternative to steerable mud motor drilling. The benefits include enhanced rate of penetration, improved hole cleaning, plus the ability to drill extended reach wells. It also offers time and cost savings for oil well operators. In RTS technology, the drill string is continually rotating while steering the bit toward a pre-determined target. Over the past fifteen years, the tool has been in operation in more than 100 wells for the mining industry in Europe. Recent advances in the technology has rendered it commercially viable for the oil and gas industry. The Well Director{sup R} is made up a rotating mandrel which is in constant rotation, and a non-rotating sleeve which stays stationary in the well bore when the tool is functioning. A measurement while drilling (MWD) system with a positive pulser is also included in the non-rotative sleeve. The tool is totally computer controlled. The Well Director{sup R} always knows the orientation of its' four steering ribs in the hole so it can continually monitor which rib has to have pressure applied. Two well tests were successfully completed in the winter of 1999. 1 fig.

  1. On-line near infrared spectroscopy as a Process Analytical Technology (PAT) tool to control an industrial seeded API crystallization.

    Science.gov (United States)

    Schaefer, C; Lecomte, C; Clicq, D; Merschaert, A; Norrant, E; Fotiadu, F

    2013-09-01

    The final step of an active pharmaceutical ingredient (API) manufacturing synthesis process consists of a crystallization during which the API and residual solvent contents have to be quantified precisely in order to reach a predefined seeding point. A feasibility study was conducted to demonstrate the suitability of on-line NIR spectroscopy to control this step in line with new version of the European Medicines Agency (EMA) guideline [1]. A quantitative method was developed at laboratory scale using statistical design of experiments (DOE) and multivariate data analysis such as principal component analysis (PCA) and partial least squares (PLS) regression. NIR models were built to quantify the API in the range of 9-12% (w/w) and to quantify the residual methanol in the range of 0-3% (w/w). To improve the predictive ability of the models, the development procedure encompassed: outliers elimination, optimum model rank definition, spectral range and spectral pre-treatment selection. Conventional criteria such as, number of PLS factors, R(2), root mean square errors of calibration, cross-validation and prediction (RMSEC, RMSECV, RMSEP) enabled the selection of three model candidates. These models were tested in the industrial pilot plant during three technical campaigns. Results of the most suitable models were evaluated against to the chromatographic reference methods. Maximum relative bias of 2.88% was obtained about API target content. Absolute bias of 0.01 and 0.02% (w/w) respectively were achieved at methanol content levels of 0.10 and 0.13% (w/w). The repeatability was assessed as sufficient for the on-line monitoring of the 2 analytes. The present feasibility study confirmed the possibility to use on-line NIR spectroscopy as a PAT tool to monitor in real-time both the API and the residual methanol contents, in order to control the seeding of an API crystallization at industrial scale. Furthermore, the successful scale-up of the method proved its capability to be

  2. Combining microwave resonance technology to multivariate data analysis as a novel PAT tool to improve process understanding in fluid bed granulation.

    Science.gov (United States)

    Lourenço, Vera; Herdling, Thorsten; Reich, Gabriele; Menezes, José C; Lochmann, Dirk

    2011-08-01

    A set of 192 fluid bed granulation batches at industrial scale were in-line monitored using microwave resonance technology (MRT) to determine moisture, temperature and density of the granules. Multivariate data analysis techniques such as multiway partial least squares (PLS), multiway principal component analysis (PCA) and multivariate batch control charts were applied onto collected batch data sets. The combination of all these techniques, along with off-line particle size measurements, led to significantly increased process understanding. A seasonality effect could be put into evidence that impacted further processing through its influence on the final granule size. Moreover, it was demonstrated by means of a PLS that a relation between the particle size and the MRT measurements can be quantitatively defined, highlighting a potential ability of the MRT sensor to predict information about the final granule size. This study has contributed to improve a fluid bed granulation process, and the process knowledge obtained shows that the product quality can be built in process design, following Quality by Design (QbD) and Process Analytical Technology (PAT) principles.

  3. Strategic framework for education and training in Quality by Design (QbD) and process analytical technology (PAT)

    DEFF Research Database (Denmark)

    de Matas, Marcel; De Beer, Thomas; Folestad, Staffan

    2016-01-01

    The regulatory and technical landscape of the pharmaceutical field is rapidly evolving from one focused predominantly on development of small molecules, using well established manufacturing technologies towards an environment in which biologicals and complex modalities are being developed using a...

  4. Center Director Bridges visits Disability Awareness and Action working Group Technology Fair

    Science.gov (United States)

    1999-01-01

    Center Director Roy Bridges stops to pet one of the dogs that serves with Canine Companions for Independence, a vendor displaying its capabilities at the Disability Awareness and Action Working Group (DAAWG) 1999 Technology Fair being held Oct. 20-21 at Kennedy Space Center. Standing at the right is Carol Cavanaugh, with KSC Public Services; behind Bridges is Nancie Strott (left), a multi-media specialist with Dynacs and chairperson of the Fair, and Sterling Walker (right), director of Engineering Development and chairman of DAAWG. The Fair is highlighting vendors demonstrating mobility, hearing, vision and silent disability assistive technology. The purpose is to create an awareness of the types of technology currently available to assist people with various disabilities in the workplace. The theme is that of this year's National Disability Employment Awareness Month, 'Opening Doors to Ability.' Some of the other vendors participating are Goodwill Industries, Accessible Structures, Division of Blind Services, Space Coast Center for Independent Living, KSC Fitness Center and Delaware North Parks Services.

  5. NASA Langley Systems Analysis & Concepts Directorate Technology Assessment/Portfolio Analysis

    Science.gov (United States)

    Cavanaugh, Stephen; Chytka, Trina; Arcara, Phil; Jones, Sharon; Stanley, Doug; Wilhite, Alan W.

    2006-01-01

    Systems analysis develops and documents candidate mission and architectures, associated system concepts, enabling capabilities and investment strategies to achieve NASA s strategic objectives. The technology assessment process connects the mission and architectures to the investment strategies. In order to successfully implement a technology assessment, there is a need to collect, manipulate, analyze, document, and disseminate technology-related information. Information must be collected and organized on the wide variety of potentially applicable technologies, including: previous research results, key technical parameters and characteristics, technology readiness levels, relationships to other technologies, costs, and potential barriers and risks. This information must be manipulated to facilitate planning and documentation. An assessment is included of the programmatic and technical risks associated with each technology task as well as potential risk mitigation plans. Risks are assessed and tracked in terms of likelihood of the risk occurring and consequences of the risk if it does occur. The risk assessments take into account cost, schedule, and technical risk dimensions. Assessment data must be simplified for presentation to decision makers. The Systems Analysis and Concepts Directorate (SACD) at NASA Langley Research Center has a wealth of experience in performing Technology Assessment and Portfolio Analysis as this has been a business line since 1978.

  6. Funding and Strategic Alignment Guidance for Infusing Small Business Innovation Research Technology into Aeronautics Research Mission Directorate Projects for 2016

    Science.gov (United States)

    Nguyen, Hung D.; Steele, Gynelle C.

    2017-01-01

    This report is intended to help NASA program and project managers incorporate Small Business Innovation Research (SBIR) technologies into NASA Aeronautics Research Mission Directorate (ARMD) projects. Other Government and commercial project managers interested in ARMD funding opportunities through NASA's SBIR program will find this report useful as well.

  7. Sleep technologists educational needs assessment: a survey of polysomnography, electroneurodiagnostic technology, and respiratory therapy education program directors.

    Science.gov (United States)

    Wells, Mary Ellen; Vaughn, Bradley V

    2013-10-15

    In this study, we assessed the community and educational needs for sleep technologists by surveying program directors of nationally accredited polysomnography, electroneurodiagnostic technology, and respiratory care educational programs. Currently, little is known about our educational capacity and the need for advanced degrees for sleep medicine technical support. A questionnaire was developed about current and future community and educational needs for sleep technologists. The questionnaire was sent to directors of CAAHEP-accredited polysomnography and electroneurodiagnostic technology programs (associate degree and certificate programs), and directors of CoARC-accredited respiratory therapy associate degree and bachelor degree programs (n = 358). Qualitative and quantitative data were collected via an internet survey tool. Data analysis was conducted with the IBM SPSS statistical package and included calculating means and standard deviations of the frequency of responses. Qualitative data was analyzed and classified based on emerging themes. One hundred seven of 408 program directors completed the survey. Seventy-four percent agreed that demand for qualified sleep technologists will increase, yet 50% of those surveyed believe there are not enough educational programs to meet the demand. Seventy-eight percent of those surveyed agreed that the educational requirements for sleep technologists will soon increase; 79% of those surveyed believe sleep centers have a need for technologists with advanced training or specialization. Our study shows educators of associate and certificate degree programs believe there is a need for a bachelor's degree in sleep science and technology.

  8. 75 FR 16491 - Science and Technology Directorate; Submission for Review; Information Collection Request for the...

    Science.gov (United States)

    2010-04-01

    ...The Department of Homeland Security (DHS) invites the general public to comment on a new data collection form for the Science and Technology Directorate (S&T) First Responders Community of Practice (FRCoP): User Registration Page (DHS Form 10059 (9/09)). The FRCoP web- based tool will be collecting profile information from first responders and select authorized non-first responder users to facilitate networking and formation of online communities. All users will be required to authenticate prior to entering the site. In addition, the tool will provide members the capability to create wikis, discussion threads, blogs, and documents allowing them to enter and upload content in accordance with the site's Rules of Behavior. Members will also be able to participate in threaded discussions and comment on other members' content. The S&T FRCoP program is responsible for providing a collaborative environment for the first responder community to share information, best practices, and lessons learned. Section 313 of the Homeland Security Act of 2002 (Pub. L. 107-296) established this requirement. This notice and request for comments is required by the Paperwork Reduction Act of 1995 (Pub. L. 104-13, 44 U.S.C. chapter 35).

  9. PAT for vaccines: The first stage of PAT implementation for development of a well-defined whole-cell vaccine against whooping cough disease

    NARCIS (Netherlands)

    Streefland, M.; Waterbeemd, van de B.; Happe, R.P.; Pol, van der L.A.; Beuvery, E.C.; Tramper, J.; Martens, D.E.

    2007-01-01

    Since variation in process time and process output is commonly accepted to be inevitable for biological processes, application of Process Analytical Technologies (PAT) on these processes is challenging. In this paper the applicability of PAT on the cultivation of Bordetella pertussis bacteria as par

  10. Computation Directorate and Science& Technology Review Computational Science and Research Featured in 2002

    Energy Technology Data Exchange (ETDEWEB)

    Alchorn, A L

    2003-04-04

    Thank you for your interest in the activities of the Lawrence Livermore National Laboratory Computation Directorate. This collection of articles from the Laboratory's Science & Technology Review highlights the most significant computational projects, achievements, and contributions during 2002. In 2002, LLNL marked the 50th anniversary of its founding. Scientific advancement in support of our national security mission has always been the core of the Laboratory. So that researchers could better under and predict complex physical phenomena, the Laboratory has pushed the limits of the largest, fastest, most powerful computers in the world. In the late 1950's, Edward Teller--one of the LLNL founders--proposed that the Laboratory commission a Livermore Advanced Research Computer (LARC) built to Livermore's specifications. He tells the story of being in Washington, DC, when John Von Neumann asked to talk about the LARC. He thought Teller wanted too much memory in the machine. (The specifications called for 20-30,000 words.) Teller was too smart to argue with him. Later Teller invited Von Neumann to the Laboratory and showed him one of the design codes being prepared for the LARC. He asked Von Neumann for suggestions on fitting the code into 10,000 words of memory, and flattered him about ''Labbies'' not being smart enough to figure it out. Von Neumann dropped his objections, and the LARC arrived with 30,000 words of memory. Memory, and how close memory is to the processor, is still of interest to us today. Livermore's first supercomputer was the Remington-Rand Univac-1. It had 5600 vacuum tubes and was 2 meters wide by 4 meters long. This machine was commonly referred to as a 1 KFlop machine [E+3]. Skip ahead 50 years. The ASCI White machine at the Laboratory today, produced by IBM, is rated at a peak performance of 12.3 TFlops or E+13. We've improved computer processing power by 10 orders of magnitude in 50 years, and I do

  11. Prospects for multivariate classification of a pharmaceutical intermediate with near-infrared spectroscopy as a process analytical technology (PAT) production control supplement.

    Science.gov (United States)

    Märk, Julia; Andre, Max; Karner, Martin; Huck, Christian W

    2010-10-01

    NIR spectroscopy was applied to develop a fast and reliable quality control system for a pharmaceutical substance to support information obtained through PAT surveillance of its manufacturing process. After calculating different quantitative calibrations of the substance's key quality parameters, a general classification model has been derived to capture the over-all product grade. The final spectral quality conformity model consisting of 96 representative batches - covering high process variability - was sensibilized toward five important quality parameters by their incorporation as PLS responses. The model characteristics were extensively investigated and interpreted to derive a reasonable limit for the reduced chemometric summary quality measure (Hotteling's T(2)). Through this parameter new batches can be assessed easily by their NIR spectra, using versatile test batches for confirmation. Different sets of good quality batches, bad production batches beyond the respective chemical quality limit and synthetic batches exactly at the limit could be accurately assigned through their multivariate evaluation to a large extend. However, high model sensitivity to non-relevant product properties can lead to limited applicability of the model. This may be caused by restricted bandwidth of quality parameters in production environment for calibration, repack effects and high process instability.

  12. Quality-by-Design (QbD): an integrated process analytical technology (PAT) approach for real-time monitoring and mapping the state of a pharmaceutical coprecipitation process.

    Science.gov (United States)

    Wu, Huiquan; Khan, Mansoor A

    2010-03-01

    In this work, an integrated PAT approach was developed for monitoring a pharmaceutical (naproxen) and a polymer (eudragit) coprecipitation process: real-time in-line near-infrared (NIR) absorbance monitoring, real-time on-line turbidity monitoring, and in situ crystal size monitoring. The data and information obtained through these three monitoring techniques confirmed the observation of the onsets of three distinct stages: incubation, nucleation, and crystal growth. The process trajectory constructed based on results of applying principal component analysis (PCA) to either process NIR spectra data or process turbidity profile, clearly demonstrated that various distinguishable process events, including incubation, nucleation, and crystal growth, could be accurately tracked and differentiated. These findings were further supported by process knowledge and information, such as process design, process sequence, thermodynamic and mass-transfer analysis. Therefore, this work provides a case study that illustrated a rational approach to develop a science-based and knowledge-based process monitoring strategy, which is essential for establishing both a suitable process control strategy and an operational process space for a pharmaceutical unit operation. 2009 Wiley-Liss, Inc. and the American Pharmacists Association

  13. Technology transfer from havana hospitals to primary care: yamila de armas, MD. Deputy director, provincial health department, havana city province.

    Science.gov (United States)

    Giraldo, Gloria

    2009-01-01

    Dr Yamila de Armas has occupied an array of posts since finishing her residency in family medicine in her home province of Cienfuegos in 1992. She has served as a family doctor; polyclinic, municipal and provincial health director; medical school dean; and twice vice minister of public health. But few would doubt her toughest job is the one she has now: deputy director of the Havana City Provincial Health Department, in charge of medical services for the 2.2 million people living in Cuba's complex, sprawling capital. It was here in 2002-2003 that the program was launched to repair, refurbish and expand the country's nearly 500 community polyclinics. Key to the effort was equipping these facilities with a broader range of new and upgraded medical technology. Dr de Armas offers MEDICC Review her reflections on the results five years later.

  14. 3 CFR - Designation of Officers of the Office of Science and Technology Policy To Act as Director

    Science.gov (United States)

    2010-01-01

    ... duties of the office of the Director of OSTP (Director), during any period in which the Director has died, resigned, or otherwise become unable to perform the functions and duties of the office of the Director, until such time as the Director is able to perform the functions and duties of that office:...

  15. 2 March 2012 - US Google Management Team Executive Chairman E. Schmidt visiting the LHC superconducting magnet test hall with Director for Accelerators and Technology S. Myers and Head of Technology Department F. Bordry; signing the guest book with CERN Director-General R. Heuer.

    CERN Multimedia

    Maximilien Brice

    2012-01-01

    2 March 2012 - US Google Management Team Executive Chairman E. Schmidt visiting the LHC superconducting magnet test hall with Director for Accelerators and Technology S. Myers and Head of Technology Department F. Bordry; signing the guest book with CERN Director-General R. Heuer.

  16. USCA, a codeveloped piece of technology, is presented to Bridges, KSC Director, by Saputo, L-3 Commu

    Science.gov (United States)

    1997-01-01

    William Saputo, L-3 Communications, presents a new piece of technology, developed through a National Aeronautics and Space Administration (NASA) partnership with industry, to Kennedy Space Center (KSC) Director Roy Bridges, Jr. (second from left). The piece of technology being presented, the Universal Signal Conditioning Amplifier (USCA), is a key component of the codeveloped Automated Data Acquisition System (ADAS) that measures temperature, pressure and vibration at KSC's launch pads. The breakthrough technology is expected to reduce sensor setup and configuration times from hours to seconds. KSC teamed up with Florida's Technological Research and Development Authority and manufacturer L-3 Communications to produce a system that would benefit the aerospace industry and other commercial markets.

  17. In-line and real-time process monitoring of a freeze drying process using Raman and NIR spectroscopy as complementary process analytical technology (PAT) tools.

    Science.gov (United States)

    De Beer, T R M; Vercruysse, P; Burggraeve, A; Quinten, T; Ouyang, J; Zhang, X; Vervaet, C; Remon, J P; Baeyens, W R G

    2009-09-01

    The aim of the present study was to examine the complementary properties of Raman and near infrared (NIR) spectroscopy as PAT tools for the fast, noninvasive, nondestructive and in-line process monitoring of a freeze drying process. Therefore, Raman and NIR probes were built in the freeze dryer chamber, allowing simultaneous process monitoring. A 5% (w/v) mannitol solution was used as model for freeze drying. Raman and NIR spectra were continuously collected during freeze drying (one Raman and NIR spectrum/min) and the spectra were analyzed using principal component analysis (PCA) and multivariate curve resolution (MCR). Raman spectroscopy was able to supply information about (i) the mannitol solid state throughout the entire process, (ii) the endpoint of freezing (endpoint of mannitol crystallization), and (iii) several physical and chemical phenomena occurring during the process (onset of ice nucleation, onset of mannitol crystallization). NIR spectroscopy proved to be a more sensitive tool to monitor the critical aspects during drying: (i) endpoint of ice sublimation and (ii) monitoring the release of hydrate water during storage. Furthermore, via NIR spectroscopy some Raman observations were confirmed: start of ice nucleation, end of mannitol crystallization and solid state characteristics of the end product. When Raman and NIR monitoring were performed on the same vial, the Raman signal was saturated during the freezing step caused by reflected NIR light reaching the Raman detector. Therefore, NIR and Raman measurements were done on a different vial. Also the importance of the position of the probes (Raman probe above the vial and NIR probe at the bottom of the sidewall of the vial) in order to obtain all required critical information is outlined. Combining Raman and NIR spectroscopy for the simultaneous monitoring of freeze drying allows monitoring almost all critical freeze drying process aspects. Both techniques do not only complement each other, they also

  18. Dr Phil Mjwara Director General, Department of Science and Technology (DST) Ministry of Science and Technology Republic of South Africa visit the Alice experiment introduce by Prof. Jurgen Schukraft, spokeperson for Alice.

    CERN Document Server

    Maximilien Brice

    2007-01-01

    Dr Phil Mjwara Director General, Department of Science and Technology (DST) Ministry of Science and Technology Republic of South Africa visit the Alice experiment introduce by Prof. Jurgen Schukraft, spokeperson for Alice.

  19. 16 October 2012 - Norwegian University of Science and Technology Rector Digernes in the ATLAS visitor centre with Senior Norwegian S. Stapnes and J. Vigen; signing the guest book with Director for Accelerators and Technology S. Myers.

    CERN Multimedia

    Jacques Fichet

    2012-01-01

    16 October 2012 - Norwegian University of Science and Technology Rector Digernes in the ATLAS visitor centre with Senior Norwegian S. Stapnes and J. Vigen; signing the guest book with Director for Accelerators and Technology S. Myers.

  20. Visit of H.E. Mr. Attila Chikan, Minister of Economic Affairs, Prof. Adam Török, President, National Committee for Technological Development, Mr. Pal Koncz, Deputy Director General, National Committee for Technological Development, Hungary

    CERN Multimedia

    Laurent Guiraud

    1999-01-01

    Visit of H.E. Mr. Attila Chikan, Minister of Economic Affairs, Prof. Adam Török, President, National Committee for Technological Development, Mr. Pal Koncz, Deputy Director General, National Committee for Technological Development, Hungary

  1. Dr Hiroshi Ikukawa Director Planning and Evaluation Division Science and Technology Policy Bureau Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan and Mr Robert Aymar signed an accord for the CERN.

    CERN Document Server

    Claudia Marcelloni

    2007-01-01

    Dr Hiroshi Ikukawa Director Planning and Evaluation Division Science and Technology Policy Bureau Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan and Mr Robert Aymar signed an accord for the CERN.

  2. New PAT tools for assessing content uniformity, sampling error, and degree of crystallinity in pharmaceutical tablets

    DEFF Research Database (Denmark)

    Warnecke, Solveig

    . The real advantage of PAT tools lay in the combination of the different disciplines. This could be spectroscopy-based process analyzer that monitors the pharmaceutical product including latent factors that could influence on the final product quality. Chemometric data treatment can then be used to extract......The pharmaceutical industry faces considerable challenges due to an increasing complexity of products, greater competition in the generic drug arena, and higher regulatory demands to ensure safe and effective pharmaceutical products. Process analytical technology (PAT) tools can provide knowledge...... of the pharmaceutical drug, both during development and throughout the production. The usage of PAT tools is encouraged by the regulatory authorities, and therefore the interest in new and improved PAT tools is increasing. The main purpose of introducing Quality by Design (QbD) and PAT in pharmaceutical production...

  3. Funding and Strategic Alignment Guidance for Infusing Small Business Innovation Research Technology Into Aeronautics Research Mission Directorate Programs and Projects for 2015

    Science.gov (United States)

    Nguyen, Hung D.; Steele, Gynelle C.

    2016-01-01

    This report is intended to help NASA program and project managers incorporate Small Business Innovation Research/Small Business Technology Transfer (SBIR)/(STTR) technologies into NASA Aeronautics Research Mission Directorate (ARMD) projects. Other Government and commercial projects managers can also find this useful.

  4. Funding and Strategic Alignment Guidance for Infusing Small Business Innovation Research Technology into NASA Programs Associated with the Science Mission Directorate

    Science.gov (United States)

    Nguyen, Hung D.; Steele, Gynelle C.

    2015-01-01

    This report is intended to help NASA program and project managers incorporate Small Business Innovation Research/Small Business Technology Transfer (SBIR/STTR) technologies that have gone through Phase II of the SBIR program into NASA Science Mission Directorate (SMD) programs. Other Government and commercial project managers can also find this information useful.

  5. Funding and Strategic Alignment Guidance for Infusing Small Business Innovation Research Technology into NASA Programs Associated with the Aeronautics Research Mission Directorate

    Science.gov (United States)

    Nguyen, Hung D.; Steele, Gynelle C.

    2015-01-01

    This report is intended to help NASA program and project managers incorporate Small Business Innovation Research/Small Business Technology Transfer (SBIR/STTR) technologies that have gone through Phase II of the SBIR program into NASA Aeronautics and Mission Directorate (ARMD) programs. Other Government and commercial program managers can also find this information useful.

  6. Funding and Strategic Alignment Guidance for Infusing Small Business Innovation Research Technology Into Science Mission Directorate Projects at Glenn Research Center for 2015

    Science.gov (United States)

    Nguyen, Hung D.; Steele, Gynelle C.

    2016-01-01

    This report is intended to help NASA program and project managers incorporate Glenn ResearchCenter Small Business Innovation Research/Small Business Technology Transfer (SBIR)/(STTR)technologies into NASA Science Mission Directorate (SMD) programs/projects. Other Government and commercial project managers can also find this useful.

  7. Funding and Strategic Alignment Guidance for Infusing Small Business Innovation Research Technology Into NASA Programs Associated With the Human Exploration and Operations Mission Directorate

    Science.gov (United States)

    Nguyen, Hung D.; Steele, Gynelle C.

    2015-01-01

    This report is intended to help NASA program and project managers incorporate Small Business Innovation Research/Small Business Technology Transfer (SBIR/STTR) technologies that have gone through Phase II of the SBIR program into NASA Human Exploration and Operations Mission Directorate (HEOMD) programs. Other Government and commercial project managers can also find this information useful.

  8. Funding and Strategic Alignment Guidance for Infusing Small Business Innovation Research Technology Into Human Exploration and Operations Mission Directorate Projects for 2016

    Science.gov (United States)

    Nguyen, Hung D.; Steele, Gynelle C.

    2017-01-01

    This report is intended to help NASA program and project managers incorporate Small Business Innovation Research Small Business Technology Transfer (SBIR/STTR) technologies into NASA Human Exploration and Operations Mission Directorate (HEOMD) projects. Other Government and commercial projects managers can also find this useful. Space Transportation; Life Support and Habitation Systems; Extra-Vehicular Activity; High EfficiencySpace Power; Human Exploration and Operations Mission,

  9. Test results of the optical PAT test bed for satellite laser communications

    Science.gov (United States)

    Sun, Jianfeng; Liu, Liren; Zhou, Yu; Liu, De'an

    2008-08-01

    Satellite laser communication systems offer many advantages such as high data rate, small sized equipment, low consumption electric power and others. Recent successful demonstrations of laser communications have demonstrated the feasibility of some of the key aspects of this technology. Sub-microradian pointing, acquisition, and tracking (PAT) functions are key issue to establish the laser communication system in space. The terminals must perform a series of onground test to evaluate characteristics of The PAT performances before flight test. So an optical dynamical PAT test bed is developed to perform ground test of a laser terminal. In this paper, we detail the separate test and the system test results of the optical dynamical PAT test bed. The test was carried out by auto-collimation method, the precision deflect accuracy, scan accuracy and deflect scan accuracy are obtained.

  10. 5th October 2011 - Vienna Science and Technology Fund Board of Directors ((WWTF) led by Its President, Lord Mayor and Governor of Vienna M. Häupl, signing the guest book with Head of International relations F. Pauss and Director for Administration and General Infrastructure S. Lettow.

    CERN Multimedia

    2011-01-01

    5th October 2011 - Vienna Science and Technology Fund Board of Directors ((WWTF) led by Its President, Lord Mayor and Governor of Vienna M. Häupl, signing the guest book with Head of International relations F. Pauss and Director for Administration and General Infrastructure S. Lettow.

  11. Chairman of the DELL Board of Directors and Chief Executive Officer Michael S. Dell with CERN Director-General R. Heuer and in front of the ATLAS detector (centre) with ATLAS Deputy Spokesperson A. Lankford (left) and Information Technology Department Head F. Hemmer on 26th January 2010.

    CERN Multimedia

    Maximilien Brice

    2010-01-01

    Chairman of the DELL Board of Directors and Chief Executive Officer Michael S. Dell with CERN Director-General R. Heuer and in front of the ATLAS detector (centre) with ATLAS Deputy Spokesperson A. Lankford (left) and Information Technology Department Head F. Hemmer on 26th January 2010.

  12. Signature of the Agreement between the University of Liverpool, acting on behalf of the Cockcroft Institute, represented by Inaugural Director of Cockcroft Institute S. Chattopadhyay and the European Organization for Nuclear Research represented by Director-General R. Aymar,concerning collaboration between the Cockcroft Institute and CERN in Accelerator Physics and Technologies.

    CERN Multimedia

    Claudia Marcelloni

    2008-01-01

    Signature of the Agreement between the University of Liverpool, acting on behalf of the Cockcroft Institute, represented by Inaugural Director of Cockcroft Institute S. Chattopadhyay and the European Organization for Nuclear Research represented by Director-General R. Aymar,concerning collaboration between the Cockcroft Institute and CERN in Accelerator Physics and Technologies.

  13. Funding and Strategic Alignment Guidance for Infusing Small Business Innovation Research Technology Into Aeronautics Research Mission Directorate Projects at NASA Glenn Research Center for 2015

    Science.gov (United States)

    Nguyen, Hung D.; Steele, Gynelle C.; Morris, Jessica R.

    2015-01-01

    This document is intended to enable the more effective transition of NASA Glenn Research Center (GRC) SBIR technologies funded by the Small Business Innovation Research (SBIR) program as well as its companion, the Small Business Technology Transfer (STTR) program into NASA Aeronautics Research Mission Directorate (ARMD) projects. Primarily, it is intended to help NASA program and project managers find useful technologies that have undergone extensive research and development (RRD), through Phase II of the SBIR program; however, it can also assist non-NASA agencies and commercial companies in this process. aviation safety, unmanned aircraft, ground and flight test technique, low emissions, quiet performance, rotorcraft

  14. Chinese Term Extraction Based on PAT Tree

    Institute of Scientific and Technical Information of China (English)

    ZHANG Feng; FAN Xiao-zhong; XU Yun

    2006-01-01

    A new method of automatic Chinese term extraction is proposed based on Patricia (PAT) tree. Mutual information is calculated based on prefix searching in PAT tree of domain corpus to estimate the internal associative strength between Chinese characters in a string. It can improve the speed of term candidate extraction largely compared with methods based on domain corpus directly. Common collocation suffix, prefix bank are constructed and term part of speech (POS) composing rules are summarized to improve the precision of term extraction. Experiment results show that the F-measure is 74.97 %.

  15. Independent Directors

    DEFF Research Database (Denmark)

    Ringe, Wolf-Georg

    2013-01-01

    This paper re-evaluates the corporate governance concept of ‘board independence’ against the disappointing experiences during the 2007-08 financial crisis. Independent or outside directors had long been seen as an essential tool to improve the monitoring role of the board. Yet the crisis revealed...... that they did not prevent firms' excessive risk taking; further, these directors sometimes showed serious deficits in understanding the business they were supposed to control, and remained passive in addressing structural problems. A closer look reveals that under the surface of seemingly unanimous consensus...... about board independence in Western jurisdictions, a surprising disharmony prevails about the justification, extent and purpose of independence requirements. These considerations lead me to question the benefits of the current system. Instead, this paper proposes a new, ‘functional’ concept of board...

  16. Dr Kathryn Beers, Assistant Director Physical Sciences and Engineering, Office of Science and Technology Policy Executive Office of the President United States of America visit the CMS experiment at point 5.

    CERN Multimedia

    Maximilien Brice

    2007-01-01

    Dr Kathryn Beers, Assistant Director Physical Sciences and Engineering, Office of Science and Technology Policy Executive Office of the President United States of America visit the CMS experiment at point 5.

  17. Chinese Commission of Science Technology and Industry for National Defense Senior Vice Minister CHEN Qiufa exchanging gifts at luncheon and signing the Guest Book on 1st November 2007 with CERN Director-General R. Aymar.

    CERN Multimedia

    Maximilien Brice

    2007-01-01

    Chinese Commission of Science Technology and Industry for National Defense Senior Vice Minister CHEN Qiufa exchanging gifts at luncheon and signing the Guest Book on 1st November 2007 with CERN Director-General R. Aymar.

  18. 7 March 2013 -Stanford University Professor N. McKeown FREng, Electrical Engineering and Computer Science and B. Leslie, Creative Labs visiting CERN Control Centre and the LHC tunnel with Director for Accelerators and Technology S. Myers.

    CERN Multimedia

    Anna Pantelia

    2013-01-01

    7 March 2013 -Stanford University Professor N. McKeown FREng, Electrical Engineering and Computer Science and B. Leslie, Creative Labs visiting CERN Control Centre and the LHC tunnel with Director for Accelerators and Technology S. Myers.

  19. Wolfsberg Executive Director P. Guptara at ATLAS experiment with ATLAS Resources Coordinator M. Nordberg, LHC machine Technical Coordination and Planning P. Proudlock and Information Technology Department Head W. von Rüden on 21 September 2006.

    CERN Multimedia

    Maximilien Brice

    2006-01-01

    Wolfsberg Executive Director P. Guptara at ATLAS experiment with ATLAS Resources Coordinator M. Nordberg, LHC machine Technical Coordination and Planning P. Proudlock and Information Technology Department Head W. von Rüden on 21 September 2006.

  20. 28 October 2013- Former US Vice President A. Gore signing the guest book with Technology Department Head F. Bordry, Head of International Relations R. Voss, Director for Research and Scientific Computing S. Bertolucci and CMS Collaboration Spokesperson J. Incandela.

    CERN Multimedia

    Maximilien Brice

    2013-01-01

    28 October 2013- Former US Vice President A. Gore signing the guest book with Technology Department Head F. Bordry, Head of International Relations R. Voss, Director for Research and Scientific Computing S. Bertolucci and CMS Collaboration Spokesperson J. Incandela.

  1. 4 April 2013 - Spanish State Secretary of Science, Development and Innovation C. Vela Olmo in the LHC tunnel with Technology Department Head F. Bordry and signing the guest book with CERN Director-General R. Heuer.

    CERN Multimedia

    Anna Pantelia

    2013-01-01

    4 April 2013 - Spanish State Secretary of Science, Development and Innovation C. Vela Olmo in the LHC tunnel with Technology Department Head F. Bordry and signing the guest book with CERN Director-General R. Heuer.

  2. 18 MArch 2008 - Director, Basic and Generic Research Division, Research Promotion Bureau, Japanese Ministry of Education, Culture, Sports, Science and Technology Prof.Ohtake visiting ATLAS cavern with Spokesperson P. Jenni.

    CERN Multimedia

    Maximilien Brice

    2008-01-01

    18 MArch 2008 - Director, Basic and Generic Research Division, Research Promotion Bureau, Japanese Ministry of Education, Culture, Sports, Science and Technology Prof.Ohtake visiting ATLAS cavern with Spokesperson P. Jenni.

  3. Signature of the CERN – EGO (European Gravitational Observatory) Agreement concerning Collaboration in Scientific, Technological, Educational and other Domains of Mutual Interest, by R. Heuer, Director-General and Prof. F. Ferrini.

    CERN Multimedia

    Maximilien Brice

    2012-01-01

    Signature of the CERN – EGO (European Gravitational Observatory) Agreement concerning Collaboration in Scientific, Technological, Educational and other Domains of Mutual Interest, by R. Heuer, Director-General and Prof. F. Ferrini.

  4. 24th May 2011 - ITER Organization Director-General O.Motojima visiting SM18 with Technology Department Head F. Bordry and Deputy L. Rossi, accompanied by Adviser for Relations with ITER J.-P. Koutchouk.

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    24th May 2011 - ITER Organization Director-General O.Motojima visiting SM18 with Technology Department Head F. Bordry and Deputy L. Rossi, accompanied by Adviser for Relations with ITER J.-P. Koutchouk.

  5. 25 November 2008 - State Councilor in charge of Science, Technology and Education Y. Liu, People's Repblic of China, visiting AMS experiment with CERN Director-General R. Aymar and AMS Collaborator Y. Yang.

    CERN Multimedia

    Maximilien Brice

    2008-01-01

    25 November 2008 - State Councilor in charge of Science, Technology and Education Y. Liu, People's Repblic of China, visiting AMS experiment with CERN Director-General R. Aymar and AMS Collaborator Y. Yang.

  6. PatA and PatB form a functional heterodimeric ABC multidrug efflux transporter responsible for the resistance of Streptococcus pneumoniae to fluoroquinolones.

    Science.gov (United States)

    Boncoeur, Emilie; Durmort, Claire; Bernay, Benoît; Ebel, Christine; Di Guilmi, Anne Marie; Croizé, Jacques; Vernet, Thierry; Jault, Jean-Michel

    2012-10-02

    All bacterial multidrug ABC transporters have been shown to work as either homodimers or heterodimers. Two possibly linked genes, patA and patB from Streptococcus pneumococcus, that encode half-ABC transporters have been shown previously to be involved in fluoroquinolone resistance. We showed that the ΔpatA, ΔpatB, or ΔpatA/ΔpatB mutant strains were more sensitive to unstructurally related compounds, i.e., ethidium bromide or fluoroquinolones, than the wild-type R6 strain. Inside-out vesicles prepared from Escherichia coli expressing PatA and/or PatB transported Hoechst 33342, a classical substrate of multidrug transporters, only when both PatA and PatB were coexpressed. This transport was inhibited either by orthovanadate or by reserpine, and mutation of the conserved Walker A lysine residue of either PatA or PatB fully abrogated Hoechst 33342 transport. PatA, PatB, and the PatA/PatB heterodimer were purified from detergent-solubilized E. coli membrane preparations. Protein dimers were identified in all cases, albeit in different proportions. In contrast to the PatA/PatB heterodimers, homodimers of PatA or PatB failed to show a vanadate-sensitive ATPase activity. Thus, PatA and PatB need to interact together to make a functional drug efflux transporter, and they work only as heterodimers.

  7. Funding and Strategic Alignment Guidance for Infusing Small Business Innovation Research Technology Into Human Exploration and Operations Mission Directorate Projects at Glenn Research Center for 2015

    Science.gov (United States)

    Nguyen, Hung D.; Steele, Gynelle C.

    2016-01-01

    This report is intended to help NASA program and project managers incorporate Glenn Research Center Small Business Innovation Research/Small Business Technology Transfer (SBIR)/(STTR) technologies into NASA Human Exploration and Operations Mission Directorate (HEOMD) programs and projects. Other Government and commercial project managers can also find this useful. Introduction Incorporating Small Business Innovation Research (SBIR)-developed technology into NASA projects is important, especially given the Agency's limited resources for technology development. The SBIR program's original intention was for technologies that had completed Phase II to be ready for integration into NASA programs, however, in many cases there is a gap between Technology Readiness Levels (TRLs) 5 and 6 that needs to be closed. After SBIR Phase II projects are completed, the technology is evaluated against various parameters and a TRL rating is assigned. Most programs tend to adopt more mature technologies-at least TRL 6 to reduce the risk to the mission rather than adopt TRLs between 3 and 5 because those technologies are perceived as too risky. The gap between TRLs 5 and 6 is often called the "Valley of Death" (Figure 1), and historically it has been difficult to close because of a lack of funding support from programs. Several papers have already suggested remedies on how to close the gap (Refs. 1 to 4).

  8. 28 August 2013 - Director of Technical Quality Management Head of ESTEC Establishment European Space Agency F. Ongaro visiting the LHC tunnel at Point 1 with Technology Department Head F. Bordry and Technology Department J.-P. Tock; visiting the ATLAS experimental area with ATLAS Deputy Spokesperson T. Wengler and signing the guest book with CERN Director-General R. Heuer. Accompanied throughout by F. Bordry and V. Parma.

    CERN Multimedia

    Jean-Claude Gadmer

    2013-01-01

    28 August 2013 - Director of Technical Quality Management Head of ESTEC Establishment European Space Agency F. Ongaro visiting the LHC tunnel at Point 1 with Technology Department Head F. Bordry and Technology Department J.-P. Tock; visiting the ATLAS experimental area with ATLAS Deputy Spokesperson T. Wengler and signing the guest book with CERN Director-General R. Heuer. Accompanied throughout by F. Bordry and V. Parma.

  9. The role of the Department of Homeland Security, Science and Technology Directorate in the development of vaccines and diagnostics for Transboundary Animal Diseases.

    Science.gov (United States)

    Colby, M; Coats, M; Brake, D; Fine, J

    2013-01-01

    The development of countermeasures to support an effective response to Transboundary Animal Diseases (TAD) poses a challenge on a global scale and necessitates the coordinated involvement of scientists from government, industry and academia, as well as regulatory entities. The Agricultural Defense Branch under the Chemical and Biological Defense Division (CBD) of the Department of Homeland Security (DHS), Science and Technology Directorate (S&T) supports this important mission within the United States. This article provides an overview of the Agricultural Defense Branch's vaccine and diagnostic TAD project.

  10. Monitoring granulation rate processes using three PAT tools in a pilot-scale fluidized bed.

    Science.gov (United States)

    Tok, Ai Tee; Goh, Xueping; Ng, Wai Kiong; Tan, Reginald B H

    2008-01-01

    The purpose of this research was to analyze and compare the responses of three Process Analytical Technology (PAT) techniques applied simultaneously to monitor a pilot-scale fluidized bed granulation process. Real-time measurements using focused beam reflectance measurement (Lasentec FBRM) and near-infra red spectroscopy (Bruker NIR) were taken by inserting in-line probes into the fluidized bed. Non-intrusive acoustic emission measurements (Physical Acoustic AE) were performed by attaching piezoelectric sensors on the external wall of the fluidized bed. Powder samples were collected at regular intervals during the granulation process and characterized offline using laser diffraction, scanning electron microscopy, stereo-optical microscopy and loss on drying method. PAT data comprising chord length distribution and chord count (from FBRM), absorption spectra (from NIR) and average signal levels and counts (from AE) were compared with the particle properties measured using offline samples. All three PAT techniques were able to detect the three granulation regimes or rate processes (wetting and nucleation, consolidation and growth, breakage) to varying degrees of sensitivity. Being dependent on optical signals, the sensitivities of the FBRM and NIR techniques were susceptible to fouling on probe windows. The AE technique was sensitive to background fluidizing air flows and external interferences. The sensitivity, strengths and weaknesses of the PAT techniques examined may facilitate the selection of suitable PAT tools for process development and scale-up studies.

  11. 15 February 2012 - Geneva United Nations Office Director-General K.-J. Tokayev in the LHC tunnel with Adviser for Relations with international organisations M. Bona and Technology Department Head F. Bordry.

    CERN Multimedia

    Jean-claude Gadmer

    2012-01-01

    Kassym-Jomart Tokayev, director-general of the United Nations Office at Geneva, (centre picture 02), visited CERN on 15 February. He toured the LHC tunnel with Maurizio Bona, CERN’s adviser to the director-general, relations with international organizations, left, and Frédérick Bordry, CERN’s technology department head. He also visited the ATLAS underground experimental area, as well as the exhibition at the Globe of Science and Innovation.

  12. Role of gibberellins in parthenocarpic fruit development induced by the genetic system pat-3/pat-4 in tomato.

    Science.gov (United States)

    Fos, Mariano; Proaño, Karina; Nuez, Fernando; García-Martínez, José L.

    2001-04-01

    The role of gibberellins (GAs) in the induction of parthenocarpic fruit-set and growth by the pat-3/pat-4 genetic system in tomato (Lycopersicon esculentum Mill.) was investigated using wild type (WT; Cuarenteno) and a near-isogenic line derived from the German line RP75/59 (the source of pat-3/pat-4 parthenocarpy). Unpollinated WT ovaries degenerated but GA3 application induced parthenocarpic fruit growth. On the contrary, parthenocarpic growth of pat-3/pat-4 fruits, which occurs in the absence of pollination and hormone treatment, was not affected by applied GA3. Unpollinated pat-3/pat-4 fruit growth was negated by paclobutrazol, an inhibitor of ent-kaurene oxidase, and this inhibitory effect was negated by GA3. The quantification of the main GAs of the early 13-hydroxylation pathway (GA1, GA8, GA19, GA20, GA29 and GA44) in unpollinated ovaries at 3 developmental stages (flower bud, FB; pre-anthesis, PR; and anthesis, AN), by gas chromatography-selected ion monitoring, showed that the concentration of most of them was higher in pat-3/pat-4 than in WT ovaries at PR and AN stages. The concentration of GA1, suggested previously to be the active GA in tomate, was 2-4 times higher. Unpollinated pat-3/pat-4 ovaries at FB, PR and AN stages also contained relatively high amounts (5-12 ng g-1) of GA3, a GA found at less than 0.5 ng g-1 in WT ovaries. It is concluded that the mutations pat-3/pat-4 may induce natural facultative parthenocarpy capacity in tomato by increasing the concentration of GA1 and GA3 in the ovaries before pollination.

  13. ICAS-PAT: A Software for Design, Analysis and Validation of PAT Systems

    DEFF Research Database (Denmark)

    Singh, Ravendra; Gernaey, Krist; Gani, Rafiqul

    2010-01-01

    end product qualities. In an earlier article, Singh et al. [Singh, R., Gernaey, K. V., Gani, R. (2009). Model-based computer-aided framework for design of process monitoring and analysis systems. Computers & Chemical Engineering, 33, 22–42] proposed the use of a systematic model and data based...... (consisting of process knowledge as well as knowledge on measurement methods and tools) and a generic model library (consisting of process operational models). Through a tablet manufacturing process example, the application of ICAS-PAT is illustrated, highlighting as well, the main features of the software.......In chemicals based product manufacturing, as in pharmaceutical, food and agrochemical industries, efficient and consistent process monitoring and analysis systems (PAT systems) have a very important role. These PAT systems ensure that the chemicals based product is manufactured with the specified...

  14. Physics and Advanced Technologies 2001 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Jacobs, R

    2002-05-09

    The Physics and Advanced Technologies (PAT) Directorate was created in July 2000 by Bruce Tarter, Director of Lawrence Livermore National Laboratory (LLNL). The Director called for the new organization to execute and support programs that apply cutting-edge physics and advanced technology to develop integrated solutions to problems in national security, fusion energy, information science, health care, and other national grand challenges. When I was appointed a year later as the PAT Directorate's first Associate Director, I initiated a strategic planning project to develop a vision, mission, and long-term goals for the Directorate. We adopted the goal of becoming a leader in frontier physics and technology for twenty-first-century national security missions: Stockpile Stewardship, homeland security, energy independence, and the exploration of space. Our mission is to: (1) Help ensure the scientific excellence and vitality of the major LLNL programs through its leadership role in performing basic and applied multidisciplinary research and development with programmatic impact, and by recruiting and retaining science and technology leaders; (2) Create future opportunities and directions for LLNL and its major programs by growing new program areas and cutting-edge capabilities that are synergistic with, and supportive of, its national security mission; (3) Provide a direct conduit to the academic and high-tech industrial sectors for LLNL and its national security programs, through which the Laboratory gains access to frontier science and technology, and can impact the science and technology communities; (4) Leverage unique Laboratory capabilities, to advance the state universe. This inaugural PAT Annual Report begins a series that will chronicle our progress towards fulfilling this mission. I believe the report demonstrates that the PAT Directorate has a strong base of capabilities and accomplishments on which to build in meeting its goals. Some of the highlights

  15. Using PAT to accelerate the transition to continuous API manufacturing

    DEFF Research Database (Denmark)

    de Gouveia, Maria Francisca Dias Folque; Rahbek, Jesper P.; Mortensen, Asmus R.

    2017-01-01

    Significant improvements can be realized by converting conventional batch processes into continuous ones. The main drivers include reduction of cost and waste, increased safety, and simpler scale-up and tech transfer activities. Re-designing the process layout offers the opportunity to incorporate...... a set of process analytical technologies (PAT) embraced in the Quality-by-Design (QbD) framework. These tools are used for process state estimation, providing enhanced understanding of the underlying variability in the process impacting quality and yield. This work describes a road map for identifying...... methods were able to capture critical information related to the accumulation of the intermediate with very similar accuracy. NIR spectroscopy proved to be satisfactory in terms of performance, ease of installation, full-scale transferability, and stability to very adverse process conditions. As such, in...

  16. I, Director

    Science.gov (United States)

    Branzburg, Jeffrey

    2007-01-01

    Look no further than to the popularity of C-SPAN's annual video documentary competition for middle and high schoolers, and it's obvious that video editing, and the technology that comes with it, is important to today's students. In the past it was a complex, involved, and expensive process. Video editing is now within the reach of anybody with a…

  17. HCMR interview: Pat N. Groner. Interview by Montague Brown.

    Science.gov (United States)

    Groner, P N

    1992-01-01

    Pat N. Groner, President Emeritus, Baptist Health Care, Pensacola, Florida, is a man of ideas and action. Pat has ably led his hospital, was founder of the Hospital Research and Development Institute and Voluntary Hospitals of America, and is now a leader in higher education. Whenever and wherever Pat sees an opportunity to improve things, he jumps in with a hundred ideas, most of them real winners. He engages others and fights for constructive change. For all who seek models for the full life well lived, look at Pat Groner.

  18. PAT-1 safety analysis report addendum.

    Energy Technology Data Exchange (ETDEWEB)

    Weiner, Ruth F.; Schmale, David T.; Kalan, Robert J.; Akin, Lili A.; Miller, David Russell; Knorovsky, Gerald Albert; Yoshimura, Richard Hiroyuki; Lopez, Carlos; Harding, David Cameron; Jones, Perry L.; Morrow, Charles W.

    2010-09-01

    The Plutonium Air Transportable Package, Model PAT-1, is certified under Title 10, Code of Federal Regulations Part 71 by the U.S. Nuclear Regulatory Commission (NRC) per Certificate of Compliance (CoC) USA/0361B(U)F-96 (currently Revision 9). The purpose of this SAR Addendum is to incorporate plutonium (Pu) metal as a new payload for the PAT-1 package. The Pu metal is packed in an inner container (designated the T-Ampoule) that replaces the PC-1 inner container. The documentation and results from analysis contained in this addendum demonstrate that the replacement of the PC-1 and associated packaging material with the T-Ampoule and associated packaging with the addition of the plutonium metal content are not significant with respect to the design, operating characteristics, or safe performance of the containment system and prevention of criticality when the package is subjected to the tests specified in 10 CFR 71.71, 71.73 and 71.74.

  19. Popisme, Andy Warhol et Pat Hackett

    OpenAIRE

    Ghanem, Nadia

    2014-01-01

    Popisme paraît en 1980 au terme d’une collaboration entre Pat Hackett et Andy Warhol. Rédigé à la première personne sous la forme d’un journal, cet ouvrage relate les évènements qui ont marqué la vie et l’œuvre de Warhol de 1960 à 1969 et se présente comme étant une réflexion autour du concept de « pop ». Dans sa préface, Alain Cueff – à qui l’on doit la première traduction française du texte en 2007 – montre que Warhol s’attache à faire revivre l’esprit des années 1960 à travers ses amitiés ...

  20. Professor C.H. Llewellyn-Smith, CERN's Director General, with Professor J. Mariano Gago, Portuguese Minister of Science and Technology, and Prof. J. Routti, Director General of the European Commission Directorate General XII with H. Wenninger, Research-Technical Director

    CERN Multimedia

    Laurent Guiraud

    1997-01-01

    On 28-29 November, CERN is hosting a Workshop on technology transfer, to see what can be learned from the examples of the past, and how the mechanisms for getting new ideas from laboratory to marketplace can be refined.

  1. Differential expression of proton-assisted amino acid transporters (PAT[1] and PAT[2]) in tissues of neonatal pigs

    Science.gov (United States)

    The PATs have been identified as growth-regulatory nutrient sensors in Drosophila and as activators of mammalian target of rapamycin (mTOR) in mammalian cell cultures. These studies suggest that, beyond their classical function as transporters of simple amino acids (AA), the PATs act as tranceptors,...

  2. Toward Higher QA: From Parametric Release of Sterile Parenteral Products to PAT for Other Pharmaceutical Dosage Forms.

    Science.gov (United States)

    Hock, Sia Chong; Constance, Neo Xue Rui; Wah, Chan Lai

    2012-01-01

    Pharmaceutical products are generally subjected to end-product batch testing as a means of quality control. Due to the inherent limitations of conventional batch testing, this is not the most ideal approach for determining the pharmaceutical quality of the finished dosage form. In the case of terminally sterilized parenteral products, the limitations of conventional batch testing have been successfully addressed with the application of parametric release (the release of a product based on control of process parameters instead of batch sterility testing at the end of the manufacturing process). Consequently, there has been an increasing interest in applying parametric release to other pharmaceutical dosage forms, beyond terminally sterilized parenteral products. For parametric release to be possible, manufacturers must be capable of designing quality into the product, monitoring the manufacturing processes, and controlling the quality of intermediates and finished products in real-time. Process analytical technology (PAT) has been thought to be capable of contributing to these prerequisites. It is believed that the appropriate use of PAT tools can eventually lead to the possibility of real-time release of other pharmaceutical dosage forms, by-passing the need for end-product batch testing. Hence, this literature review attempts to present the basic principles of PAT, introduce the various PAT tools that are currently available, present their recent applications to pharmaceutical processing, and explain the potential benefits that PAT can bring to conventional ways of processing and quality assurance of pharmaceutical products. Last but not least, current regulations governing the use of PAT and the manufacturing challenges associated with PAT implementation are also discussed. Pharmaceutical products are generally subjected to end-product batch testing as a means of quality control. Due to the inherent limitations of conventional batch testing, this is not the most

  3. A systematic framework for design of process monitoring and control (PAT) systems for crystallization processes

    DEFF Research Database (Denmark)

    Abdul Samad, Noor Asma Fazli Bin; Sin, Gürkan; Gernaey, Krist

    2013-01-01

    for generation of the supersaturation set-point for supersaturation control, as well as a tool for design of a process monitoring and control system (also called Process Analytical Technology (PAT) system). This systematic design allows one to generate the necessary problem-chemical system specific model......A generic computer-aided framework for systematic design of a process monitoring and control system for crystallization processes has been developed to study various aspects of crystallization operations.The systematic design framework contains a generic crystallizer modelling toolbox, a tool......, the necessary supersaturation set-point as well as a PAT system design including implementation of monitoring tools and control strategies in order to produce the desired target product properties notably crystal size distribution (CSD) and shape for a wide range of crystallization processes. Application...

  4. 27 Febuary 2012 - US DoE Associate Director of Science for High Energy Physics J. Siegrist visiting the LHC superconducting magnet test hall with adviser J.-P. Koutchouk and engineer M. Bajko; in CMS experimental cavern with Spokesperson J. Incadela;in ATLAS experimental cavern with Deputy Spokesperson A. Lankford; in ALICE experimental cavern with Spokesperson P. Giubellino; signing the guest book with Director for Accelerators and Technology S. Myers.

    CERN Multimedia

    Laurent Egli

    2012-01-01

    27 Febuary 2012 - US DoE Associate Director of Science for High Energy Physics J. Siegrist visiting the LHC superconducting magnet test hall with adviser J.-P. Koutchouk and engineer M. Bajko; in CMS experimental cavern with Spokesperson J. Incadela;in ATLAS experimental cavern with Deputy Spokesperson A. Lankford; in ALICE experimental cavern with Spokesperson P. Giubellino; signing the guest book with Director for Accelerators and Technology S. Myers.

  5. 10 September 2013 - Italian Minister for Economic Development F. Zanonato visiting the ATLAS cavern with Collaboration Spokesperson D. Charlton and Italian scientists F. Gianotti and A. Di Ciaccio; signing the guest book with CERN Director-General R. Heuer and Director for Research and Scientific Computing S. Bertolucci; in the LHC tunnel with S. Bertolucci, Technology Deputy Department Head L. Rossi and Engineering Department Head R. Saban; visiting CMS cavern with Scientists G. Rolandi and P. Checchia.

    CERN Multimedia

    Jean-Claude Gadmer

    2013-01-01

    10 September 2013 - Italian Minister for Economic Development F. Zanonato visiting the ATLAS cavern with Collaboration Spokesperson D. Charlton and Italian scientists F. Gianotti and A. Di Ciaccio; signing the guest book with CERN Director-General R. Heuer and Director for Research and Scientific Computing S. Bertolucci; in the LHC tunnel with S. Bertolucci, Technology Deputy Department Head L. Rossi and Engineering Department Head R. Saban; visiting CMS cavern with Scientists G. Rolandi and P. Checchia.

  6. Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae.

    Science.gov (United States)

    Garvey, Mark I; Baylay, Alison J; Wong, Ryan L; Piddock, Laura J V

    2011-01-01

    Fifty-seven clinical isolates of Streptococcus pneumoniae were divided into four groups based on their susceptibilities to the fluoroquinolones ciprofloxacin and norfloxacin and the dyes ethidium bromide and acriflavine. Comparative reverse transcription-PCR was used to determine the level of expression of the genes patA and patB, which encode putative ABC transporters. Overexpression was observed in 14 of the 15 isolates that were resistant to both fluoroquinolones and dyes and in only 3 of 24 of those resistant to fluoroquinolones only. Isolates overexpressing patA and patB accumulated significantly less of the fluorescent dye Hoechst 33342 than wild-type isolates, suggesting that PatA and PatB are involved in efflux. Inactivation of patA and patB by in vitro mariner mutagenesis conferred hypersusceptibility to ethidium bromide and acriflavine in all isolates tested and lowered the MICs of ciprofloxacin in the patAB-overproducing and/or fluoroquinolone-resistant isolates. These data represent the first observation of overexpression of patA and patB in clinical isolates and show that PatA and PatB play a clinically relevant role in fluoroquinolone resistance.

  7. 1 November 2012 - Signature of the Co-operation Agreement between the Administrative Department of Science, Technology and Innovation (COLCIENCIAS) of Colombia and the European Organization for Nuclear Research (CERN) concerning Scientific and Technical Co-operation in High-Energy Physics and related technologies by CERN Director-General R. Heuer, witnessed by Ambassador of Colombia to Switzerland C. Turbay Quintero.

    CERN Multimedia

    Maximilien Brice

    2012-01-01

    1 November 2012 - Signature of the Co-operation Agreement between the Administrative Department of Science, Technology and Innovation (COLCIENCIAS) of Colombia and the European Organization for Nuclear Research (CERN) concerning Scientific and Technical Co-operation in High-Energy Physics and related technologies by CERN Director-General R. Heuer, witnessed by Ambassador of Colombia to Switzerland C. Turbay Quintero.

  8. 17 January 2014 - Y. Sakurada Japanese Senior Vice Minister of Education, Culture, Sports, Science and Technology signing the Guest book with CERN Director-General R. Heuer and visiting the LHC tunnel at Point 1 with Technology Department Head J.M. Jiménez. Head of International Relations R. Voss present throughout.

    CERN Multimedia

    Pantelia, Anna

    2014-01-01

    17 January 2014 - Y. Sakurada Japanese Senior Vice Minister of Education, Culture, Sports, Science and Technology signing the Guest book with CERN Director-General R. Heuer and visiting the LHC tunnel at Point 1 with Technology Department Head J.M. Jiménez. Head of International Relations R. Voss present throughout.

  9. 13 September 2013 - Chairman of the Board of Directors of the von Karman Institute Kingdom of Belgium J.-P. Contzen visiting the ATLAS experimental cavern with ATLAS Former Spokesperson P. Jenni; visiting the LHC tunnel at Point 1 with Technology Department N. Delruelle and signing the guest book with Technology Department Head F. Bordry. International Relations Adviser T. Kurtyka present.

    CERN Multimedia

    Laurent Egli (visit)

    2013-01-01

    13 September 2013 - Chairman of the Board of Directors of the von Karman Institute Kingdom of Belgium J.-P. Contzen visiting the ATLAS experimental cavern with ATLAS Former Spokesperson P. Jenni; visiting the LHC tunnel at Point 1 with Technology Department N. Delruelle and signing the guest book with Technology Department Head F. Bordry. International Relations Adviser T. Kurtyka present.

  10. 16 December 2013 - P. Lavie President of the Technion Institute of Technology in Israel visiting the ATLAS cavern with ATLAS Deputy Spokesperson T. Wengler; visiting the LHC tunnel at Point 1 with Technology Department Head F. Bordry and signing the Guest Book with CERN Director-General R. Heuer. G. Mikenberg, E. Rabinovici, Y. Rozen and S. Tarem present throughout.

    CERN Multimedia

    Jean-Claude Gadmer

    2013-01-01

    16 December 2013 - P. Lavie President of the Technion Institute of Technology in Israel visiting the ATLAS cavern with ATLAS Deputy Spokesperson T. Wengler; visiting the LHC tunnel at Point 1 with Technology Department Head F. Bordry and signing the Guest Book with CERN Director-General R. Heuer. G. Mikenberg, E. Rabinovici, Y. Rozen and S. Tarem present throughout.

  11. 14 November 2013 - Director of Indian Institute of Technology Indore P. Mathur with members of the Indian community working at CERN; visiting the LHC tunnel at Point 2, the ALICE experimental area and SM18 with ALICE Collaboration Spokesperson, Istituto Nazionale Fisica Nucleare P. Giubellino and Technology Department, Accelerator Beam Transfer Group Leader V. Mertens

    CERN Multimedia

    Jean-Claude Gadmer

    2013-01-01

    14 November 2013 - Director of Indian Institute of Technology Indore P. Mathur with members of the Indian community working at CERN; visiting the LHC tunnel at Point 2, the ALICE experimental area and SM18 with ALICE Collaboration Spokesperson, Istituto Nazionale Fisica Nucleare P. Giubellino and Technology Department, Accelerator Beam Transfer Group Leader V. Mertens

  12. X-PAT: a multiplatform patient referral data management system for small healthcare institution requirements.

    Science.gov (United States)

    Masseroli, Marco; Marchente, Mario

    2008-07-01

    We present X-PAT, a platform-independent software prototype that is able to manage patient referral multimedia data in an intranet network scenario according to the specific control procedures of a healthcare institution. It is a self-developed storage framework based on a file system, implemented in eXtensible Markup Language (XML) and PHP Hypertext Preprocessor Language, and addressed to the requirements of limited-dimension healthcare entities (small hospitals, private medical centers, outpatient clinics, and laboratories). In X-PAT, healthcare data descriptions, stored in a novel Referral Base Management System (RBMS) according to Health Level 7 Clinical Document Architecture Release 2 (CDA R2) standard, can be easily applied to the specific data and organizational procedures of a particular healthcare working environment thanks also to the use of standard clinical terminology. Managed data, centralized on a server, are structured in the RBMS schema using a flexible patient record and CDA healthcare referral document structures based on XML technology. A novel search engine allows defining and performing queries on stored data, whose rapid execution is ensured by expandable RBMS indexing structures. Healthcare personnel can interface the X-PAT system, according to applied state-of-the-art privacy and security measures, through friendly and intuitive Web pages that facilitate user acceptance.

  13. Physics and Advanced Technologies 2003 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Hazi, A; Sketchley, J

    2005-01-20

    The Physics and Advanced Technologies (PAT) Directorate overcame significant challenges in 2003 to deliver a wealth of scientific and programmatic milestones, and move toward closer alignment with programs at Lawrence Livermore National Laboratory. We acted aggressively in enabling the PAT Directorate to contribute to future, growing Lawrence Livermore missions in homeland security and at the National Ignition Facility (NIF). We made heavy investments to bring new capabilities to the Laboratory, to initiate collaborations with major Laboratory programs, and to align with future Laboratory directions. Consistent with our mission, we sought to ensure that Livermore programs have access to the best science and technology, today and tomorrow. For example, in a move aimed at revitalizing the Laboratory's expertise in nuclear and radiation detection, we brought the talented Measurement Sciences Group to Livermore from Lawrence Berkeley National Laboratory, after its mission there had diminished. The transfer to our I Division entailed significant investment by PAT in equipment and infrastructure required by the group. In addition, the move occurred at a time when homeland security funding was expected, but not yet available. By the end of the year, though, the group was making crucial contributions to the radiation detection program at Livermore, and nearly every member was fully engaged in programmatic activities. Our V Division made a move of a different sort, relocating en masse from Building 121 to the NIF complex. This move was designed to enhance interaction and collaboration among high-energy-density experimental scientists at the Laboratory, a goal that is essential to the effective use of NIF in the future. Since then, V Division has become increasingly integrated with NIF activities. Division scientists are heavily involved in diagnostic development and fielding and are poised to perform equation-of-state and high-temperature hohlraum experiments in 2004

  14. Director`s series on proliferation

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, K.C.; Price, M.E. [eds.

    1994-12-27

    The Director`s Series on Proliferation is an occasional publication of essays on the topics of nuclear, chemical, biological, and missile proliferation. The seven papers presented in this issue cover the following topics: Should the Treaty on the Nonproliferation of Nuclear Weapons (NPT) be amended?; NPT extension - Legal and procedural issues; An Indonesian view of NPT review conference issues; The treaty of Tlatelolco and the NPT - Tools for peace and development; Perspectives on cut-off, weapons dismantlement, and security assurances; Belarus and NPT challenges; A perspective on the chemical weapons convention - Lessons learned from the preparatory commission.

  15. 27 November 2014 - Warsaw University of Technology (PL) Vice-Rector for Research R. Bacewicz visitng the ALICE control room and undergorund experimental area with WUT students, accompanied by A. Charkiewicz and A. Siemko; joint signature ceremony with HNINP Director-General M. Jezabek

    CERN Multimedia

    Guillaume, Jeanneret

    2014-01-01

    CERN-PHOTO-201411-245-95: from left to right: Professor D.Sc.Ph.D. Rajmund Bacewicz, Vice-Rector for Research, Warsaw University of Technology, CERN Director-General R. Heuer and Prof. Marek Jeżabek, Director-General, Henryk Niewodniczanski Institute of Nuclear Physics, Republic of Poland

  16. Athletic Director's Survival Guide.

    Science.gov (United States)

    Koehler, Mike; Giebel, Nancy

    This book examines the duties assigned to athletic directors, offering successful strategies for achieving them and materials to make their jobs easier (e.g., sample memos, letters, forms, and charts for interacting successfully with coaches, students, administrators, and parents). Section 1 discusses the director's work with student athletes and…

  17. Transparency of director attributes

    NARCIS (Netherlands)

    van der Elst, C.F.; Horak, H.

    2013-01-01

    The composition of the board of directors is considered key for the success of the company. The current approach to compose this board is to provide shareholders and investors with individual information of the skills and experience of (candidate) directors. The information is insufficient to qualif

  18. Investigation of PAT for Advanced Sulphoaluminate MDF Cement

    Institute of Scientific and Technical Information of China (English)

    HUANG Congyun; YUAN Runzhang; LONG Shizong

    2005-01-01

    The method of examining micro-pores in sulphoaluminate MDF cement by means of the Positron Annihilation Technique (PAT) was discussed.The results show that the intensity I2 of positrons annihilation with moderate life-span (τ2≈330Ps) increases regularly with the addition of the numbers of micro-pores (less than 250(A)). Therefore, the value of I2 may be used to opitomize the compactness and integrity of the MDF cement structure. At the same time, the experiment result of PAT was compared with that of Mercury Intrusion Porosimeter (MIP).

  19. Biased inheritance of the protein PatN frees vegetative cells to initiate patterned heterocyst differentiation.

    Science.gov (United States)

    Risser, Douglas D; Wong, Francis C Y; Meeks, John C

    2012-09-18

    Heterocysts, cells specialized for nitrogen fixation in certain filamentous cyanobacteria, appear singly in a nonrandom spacing pattern along the chain of vegetative cells. A two-stage, biased initiation and competitive resolution model has been proposed to explain the establishment of this spacing pattern. There is substantial evidence that competitive resolution of a subset of cells initiating differentiation occurs by interactions between a self-enhancing activator protein, HetR, and a diffusible pentapeptide inhibitor PatS-5 (RGSGR). Results presented here show that the absence of a unique membrane protein, PatN, in Nostoc punctiforme strain ATCC 29133 leads to a threefold increase in heterocyst frequency and a fourfold decrease in the vegetative cell interval between heterocysts. A PatN-GFP translational fusion shows a pattern of biased inheritance in daughter vegetative cells of ammonium-grown cultures. Inactivation of another heterocyst patterning gene, patA, is epistatic to inactivation of patN, and transcription of patA increases in a patN-deletion strain, implying that patN may function by modulating levels of patA. The presence of PatN is hypothesized to decrease the competency of a vegetative cell to initiate heterocyst differentiation, and the cellular concentration of PatN is dependent on cell division that results in cells transiently depleted of PatN. We suggest that biased inheritance of cell-fate determinants is a phylogenetic domain-spanning paradigm in the development of biological patterns.

  20. High Performance Processors for Space Environments: A Subproject of the NASA Exploration Missions Systems Directorate "Radiation Hardened Electronics for Space Environments" Technology Development Program

    Science.gov (United States)

    Johnson, M.; Label, K.; McCabe, J.; Powell, W.; Bolotin, G.; Kolawa, E.; Ng, T.; Hyde, D.

    2007-01-01

    Implementation of challenging Exploration Systems Missions Directorate objectives and strategies can be constrained by onboard computing capabilities and power efficiencies. The Radiation Hardened Electronics for Space Environments (RHESE) High Performance Processors for Space Environments project will address this challenge by significantly advancing the sustained throughput and processing efficiency of high-per$ormance radiation-hardened processors, targeting delivery of products by the end of FY12.

  1. Multivariate PAT solutions for biopharmaceutical cultivation: current progress and limitations

    NARCIS (Netherlands)

    Mercier, S.M.; Diepenbroek, B.; Wijffels, R.H.; Streefland, M.

    2014-01-01

    Increasingly elaborate and voluminous datasets are generated by the (bio)pharmaceutical industry and are a major challenge for application of PAT and QbD principles. Multivariate data analysis (MVDA) is required to delineate relevant process information from large multi-factorial and multi-collinear

  2. Bacillus anthracis acetyltransferases PatA1 and PatA2 modify the secondary cell wall polysaccharide and affect the assembly of S-layer proteins.

    Science.gov (United States)

    Lunderberg, J Mark; Nguyen-Mau, Sao-Mai; Richter, G Stefan; Wang, Ya-Ting; Dworkin, Jonathan; Missiakas, Dominique M; Schneewind, Olaf

    2013-03-01

    The envelope of Bacillus anthracis encompasses a proteinaceous S-layer with two S-layer proteins (Sap and EA1). Protein assembly in the envelope of B. anthracis requires S-layer homology domains (SLH) within S-layer proteins and S-layer-associated proteins (BSLs), which associate with the secondary cell wall polysaccharide (SCWP), an acetylated carbohydrate that is tethered to peptidoglycan. Here, we investigated the contributions of two putative acetyltransferases, PatA1 and PatA2, on SCWP acetylation and S-layer assembly. We show that mutations in patA1 and patA2 affect the chain lengths of B. anthracis vegetative forms and perturb the deposition of the BslO murein hydrolase at cell division septa. The patA1 and patA2 mutants are defective for the assembly of EA1 in the envelope but retain the ability of S-layer formation with Sap. SCWP isolated from the patA1 patA2 mutant lacked acetyl moieties identified in wild-type polysaccharide and failed to associate with the SLH domains of EA1. A model is discussed whereby patA1- and patA2-mediated acetylation of SCWP enables the deposition of EA1 as well as BslO near the septal region of the B. anthracis envelope.

  3. 27th April 2009 - President of the Government of the Former Yugoslav Republic of Macedonia N. Gruevski welcomed by CERN Director General R. Heuer, Research and Comnputing Director S. Bertolucci, Accelerators and Technology Director S. Myers, Coordinator for External Relations F. Pauss, Non-Member States Relations Advisers J. Ellis and T. Kurtyka, and VIP and Protocol Office S. Molinari (HI-090405701-09)

    CERN Multimedia

    Maximilien Brice

    2009-01-01

    HI-0904057 10-11: General introduction to CERN by the Director General R. Heuer HI-0904057 12-25: signature of a co-operation agreeement between the Former Former Yugoslav Republic of Macedonia and CERN; signature of the guest book by the President of the Government; Exchange of gifts HI-0904057 26-32: The President of the Government welcomed by Former IT Department Head W. Rüden and Computing Centre visit; HI-0904057 33-38: Visit the LHC tunnel at Point 5 with Senior Adviser to the President of the Government Z. Dimcovski; HI-0904057 37:left: Vice Prime Minister of the Government I. Bocevski; HI-0904057 39-52: Visit CMS experimental area with Non-Member States Relations Adviser J. Ellis, UN Ambassador G. Avramchev, Senior Adviser to the President of the Government Z. Dimcovski and Collaboration Spokesperson T. Virdee. HI-0904057 53-54: Visit CMS counting room.

  4. Interlocking Directorates and Collusion

    DEFF Research Database (Denmark)

    Buch-Hansen, Hubert

    2014-01-01

    Although several works have suggested that interlocking directorates are mechanisms that have the potential to facilitate collusion, few studies have investigated the matter empirically, and none have systematically considered known cartel cases. Taking a European perspective, and focusing on four...... ties and possible overlaps between them. The analysis is based on an original dataset of European Community cartel cases and data on interlocking directorates developed by others. Very few examples are found of colluding companies that were previously directly or indirectly connected via interlocking...

  5. Structure of PatF from Prochloron didemni.

    Science.gov (United States)

    Bent, Andrew F; Koehnke, Jesko; Houssen, Wael E; Smith, Margaret C M; Jaspars, Marcel; Naismith, James H

    2013-06-01

    Patellamides are macrocyclic peptides with potent biological effects and are a subset of the cyanobactins. Cyanobactins are natural products that are produced by a series of enzymatic transformations and a common modification is the addition of a prenyl group. Puzzlingly, the pathway for patellamides in Prochloron didemni contains a gene, patF, with homology to prenylases, but patellamides are not themselves prenylated. The structure of the protein PatF was cloned, expressed, purified and determined. Prenylase activity could not be demonstrated for the protein, and examination of the structure revealed changes in side-chain identity at the active site. It is suggested that these changes have inactivated the protein. Attempts to mutate these residues led to unfolded protein.

  6. Structure of PatF from Prochloron didemni

    Science.gov (United States)

    Bent, Andrew F.; Koehnke, Jesko; Houssen, Wael E.; Smith, Margaret C. M.; Jaspars, Marcel; Naismith, James H.

    2013-01-01

    Patellamides are macrocyclic peptides with potent biological effects and are a subset of the cyanobactins. Cyanobactins are natural products that are produced by a series of enzymatic transformations and a common modification is the addition of a prenyl group. Puzzlingly, the pathway for patellamides in Prochloron didemni contains a gene, patF, with homology to prenylases, but patellamides are not themselves prenylated. The structure of the protein PatF was cloned, expressed, purified and determined. Prenylase activity could not be demonstrated for the protein, and examination of the structure revealed changes in side-chain identity at the active site. It is suggested that these changes have inactivated the protein. Attempts to mutate these residues led to unfolded protein. PMID:23722837

  7. Polyporus baudoni Pat. on Eucalyptus spp. in South Africa

    Directory of Open Access Journals (Sweden)

    G. C. A. van der Westhuizen

    1973-09-01

    Full Text Available The morphology and anatomy of the fruit-bodies and characteristics in pure culture, of Polyporus baudoni Pat., which is associated with death of species of Eucalyptus and other trees in South Africa, are described. The anatomical characters of these fruit-bodies agree with those of the type specimen, as well as with those of the type specimen of Phaeolus manihotis Heim which is shown to be synonymous. The anatomical characters of the fruit-bodies and the cultural characteristics differ from those of Polyporus schweinitzii Fr., the type of the genus Phaeolus Pat. The fruit-bodies and cultures display combinations of characters not known to occur in any other species of polypore.

  8. Dividing the pie: differential dung pat size utilization by sympatric Haematobia irritans and Musca autumnalis.

    Science.gov (United States)

    Fowler, F E; Mullens, B A

    2016-06-01

    Horn flies [Haematobia irritans (Diptera: Muscidae) (L.)] and face flies [Musca autumnalis (Diptera: Muscidae) De Geer] use the same larval resource, but their interactions are poorly studied. Dung pats (n = 350) were core sampled in the summers of 2012 and 2013 from irrigated pastures in Pomona, California, U.S.A. (34°03'N, 117°48'W) and held for face fly and horn fly emergence. Surface areas and estimated weights were recorded for each whole pat. Almost half (42.0%) of the pat cores yielded neither fly, 29.7% yielded horn flies only, 12.9% yielded face flies only and 15.4% yielded both flies. Of the fly-positive pats, surface area and mass were larger for face fly-occupied pats, whereas horn fly-occupied pats were smaller. Pats shared by the two species were intermediate. Horn flies per positive core were unaffected by the absence/presence of face flies, but half as many face flies emerged when pats were co-inhabited by horn flies. Face flies inhabited larger pats, which might better resist heating and drying, to which they are susceptible; horn flies inhabited a broad pat size range. Horn fly tolerance of lower dung moisture probably allows horn flies to colonize and survive in a wide range of pats in dry areas like southern California.

  9. PAT: From Western solid dosage forms to Chinese materia medica preparations using NIR-CI.

    Science.gov (United States)

    Zhou, Luwei; Xu, Manfei; Wu, Zhisheng; Shi, Xinyuan; Qiao, Yanjiang

    2016-01-01

    Near-infrared chemical imaging (NIR-CI) is an emerging technology that combines traditional near-infrared spectroscopy with chemical imaging. Therefore, NIR-CI can extract spectral information from pharmaceutical products and simultaneously visualize the spatial distribution of chemical components. The rapid and non-destructive features of NIR-CI make it an attractive process analytical technology (PAT) for identifying and monitoring critical control parameters during the pharmaceutical manufacturing process. This review mainly focuses on the pharmaceutical applications of NIR-CI in each unit operation during the manufacturing processes, from the Western solid dosage forms to the Chinese materia medica preparations. Finally, future applications of chemical imaging in the pharmaceutical industry are discussed.

  10. Process synthesis for natural products from plants based on PAT methodology

    DEFF Research Database (Denmark)

    2017-01-01

    generates different process flowsheet alternatives consisting of multiple separation techniques. Decision making is supported by heuristics as well as basic process information already available from previous studies. In addition, process analytical technology (PAT) framework, a part of Quality by Design...... (QbD) approach, has been included at various steps to obtain molecular level information of process streams and thereby, support the rational decision making. The formulated methodology has been used to isolate and purify artemisinin, an antimalarial drug, from dried leaves of the plant Artemisia...... and other consumer products. Therefore, process technology towards industrial scale production of such high value chemicals from plants has significant importance. In this chapter, a process synthesis methodology for recovery of natural products from plants at conceptual level is discussed. The methodology...

  11. Bridging the gap between PAT concepts and implementation: An integrated software platform for fermentation.

    Science.gov (United States)

    Chopda, Viki R; Gomes, James; Rathore, Anurag S

    2016-01-01

    Bioreactor control significantly impacts both the amount and quality of the product being manufactured. The complexity of the control strategy that is implemented increases with reactor size, which may vary from thousands to tens of thousands of litres in commercial manufacturing. The Process Analytical Technology (PAT) initiative has highlighted the need for having robust monitoring tools and effective control schemes that are capable of taking real time information about the critical quality attributes (CQA) and the critical process parameters (CPP) and executing immediate response as soon as a deviation occurs. However, the limited flexibility that present commercial software packages offer creates a hurdle. Visual programming environments have gradually emerged as potential alternatives to the available text based languages. This paper showcases development of an integrated programme using a visual programming environment for a Sartorius BIOSTAT® B Plus 5L bioreactor through which various peripheral devices are interfaced. The proposed programme facilitates real-time access to data and allows for execution of control actions to follow the desired trajectory. Major benefits of such integrated software system include: (i) improved real time monitoring and control; (ii) reduced variability; (iii) improved performance; (iv) reduced operator-training time; (v) enhanced knowledge management; and (vi) easier PAT implementation.

  12. Prediction of quality attributes of continuously produced granules using complementary pat tools.

    Science.gov (United States)

    Fonteyne, Margot; Soares, Sandra; Vercruysse, Jurgen; Peeters, Elisabeth; Burggraeve, Anneleen; Vervaet, Chris; Remon, Jean Paul; Sandler, Niklas; De Beer, Thomas

    2012-10-01

    Manufacturers of pharmaceutical solid dosage forms aim for a reduced production time and a shorter "time-to-market." Therefore, continuous manufacturing gains increasing interest in the pharmaceutical industry. For continuous manufacturing, the quality of produced pharmaceuticals should be assessed in real-time (in-line, on-line, and at-line) and not via the traditional off-line, often destructive and time-consuming analysis methods that supply the desired information only hours after sampling. This research paper evaluates three Process Analytical Technology (PAT) tools for the real-time at-line analysis of granules, which were produced using a continuous wet twin-screw granulator being part of a from powder-to-tablet production line (ConsiGma™-25). A Raman and NIR spectrometer were used together with a photometric imaging technique in order to acquire solid-state information and granule size data. These multivariate data were then used to predict the granules' moisture content, tapped and bulk density, and flowability. The three PAT tools provided complementary information for predicting these quality attributes of the continuously produced granules. The residual moisture content was mostly correlated with the spectroscopic data, whereas the imaging data had the highest predictive capability for the flowability of the granules. Copyright © 2012 Elsevier B.V. All rights reserved.

  13. Time Management for Directors

    Science.gov (United States)

    Jaffe, Ellen Hofstetter

    2005-01-01

    Time management is a skill. Like any new skill, it takes time and commitment to develop. A frequent complaint of center directors is not having enough time. Most work extremely long hours and still feel they are not getting enough done. This article presents ideas on how to manage time and work smarter, not harder. These ideas are the following:…

  14. Director Networks and Takeovers

    NARCIS (Netherlands)

    Renneboog, L.D.R.; Zhao, Y.

    2013-01-01

    Abstract: We study the impact of corporate networks on the takeover process. We find that better connected companies are more active bidders. When a bidder and a target have one or more directors in common, the probability that the takeover transaction will be successfully completed augments, and th

  15. Director networks and takeovers

    NARCIS (Netherlands)

    Renneboog, L.D.R.; Zhao, Y.

    2014-01-01

    We study the impact of corporate networks on the takeover process. We find that better connected companies are more active bidders. When a bidder and a target have one or more directors in common, the probability that the takeover transaction will be successfully completed augments, and the duration

  16. REGIONAL CUSTOMS DIRECTORATES MANAGEMENT

    Directory of Open Access Journals (Sweden)

    CABA STEFAN

    2009-05-01

    Full Text Available The management of a regional customs directorate is analyzed. A new approach of the managerial system, in the European integration context, is presented. The customs system is one of the first “doors” to a new economic, social and cultural community. For

  17. Ideas for Directors.

    Science.gov (United States)

    Child Care Information Exchange, 1987

    1987-01-01

    Presents child care center directors with a variety of relevant management ideas from business and the child care field. They include translating employee body language; leadership myths; on-the-job teacher training; undesirable bosses; wasting employee talent; voicing disagreement; employee anger; encouraging creativity; and coping with late…

  18. CNOOC Appoints New Directors

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    @@ On November 18, 2002, CNOOC Limited announced appointment of Professor Kenneth Courtis and Dr. Erwin Schurtenberger as Nonexecutive Directors of the Company effective immediately. They replaced Mr. Tso Kai Sum and Mr. Will Honeybourne who sat on the board on behalf of strategic investors and whose terms now expired.

  19. Four Women Bank Directors

    Institute of Scientific and Technical Information of China (English)

    1995-01-01

    FOUR of the five directors of state banks in Beihai City in Guangxi Zhuang Autonomous Region are women. These women show that women are no longer only able to manage family finance, but they are able to take charge of the important responsibility for state finance. The mayor of Beihai City calls them the city’s outstanding financial affairs managers.

  20. Woman Director Ma Yueying

    Institute of Scientific and Technical Information of China (English)

    1995-01-01

    Ma Yueying took office as director of the Jiaxing General Silk Mill, which had 200,000 yuan capital fund, in 1975. Since then, this mill has developed greatly. Now it has become an advanced enterprise with an annual output worth RMB¥30 million and fixed assets of RMB¥10 million.

  1. Dėl baltų *pat(is, *pat(nī pirminės reikšmės ir gramatinio statuso

    Directory of Open Access Journals (Sweden)

    Albertas Rosinas

    2011-11-01

    Full Text Available ON THE ORIGINAL MEANING AND THE GRAMMATICAL STATUS OF BALTIC *pat(is, *pat(nīSummaryOn the basis of the data from the Baltic and other Indo-European languages, the article rejects the common current view that Baltic *pat-root nouns, cf. Latv. pats ‘master, mister, husband’, pati ‘mistress, wife’, evolved from *pat-root pronouns with the meaning of ‘self’. The data from the Baltic languages lead to the conclusion that from Proto-Indo-European the Proto-Balts inherited the root noun of the consonantal declension *pat (pat (cf. I.-E. acc. sing. *potn̥> Baltic *patin and i-stem acc. sing. *avin passed to the i-stem declension, i. e. it was modified to *patis and began to be declined as an i-stem noun, although also retaining some C-stem forms; under the influence of the *patis model, *patnī gradually lost the suffix *-n- and became *patī (>Lith. patì, Latv. pati. The assumption that the Baltic nouns *patis, *patnī did not evolve from pronouns could be supported by the following: (a i-stem resp. C-stem pronominal paradigms are not characteristic of the Baltic pronominal systems; (b moreover, the Prussian language (like the German, Slavonic and Indo-Iranian languages never possessed *pat-root pronouns.In the East Baltic languages, pronouns with the meaning of ‘self’ evolved from the nouns *pat(is, *pat(nī in the process of pronominalization, which originally occurred in the sphere of the addressee and the non-participant person. In the process of pronominalization, *pat(is eventually acquired endings typical of pronouns, cf. dat. sing, pačiam <— pačiamu(i, ines. sing, patime and a newer form pačiame, dat. pl. patiems ← patiemus.The identifying particle pat in the collocative pronouns toks pat, tokia pat

  2. Scenario-based Training: Director's Cut

    NARCIS (Netherlands)

    Peeters, M.M.M.; Van den Bosch, K.; Meyer, J-J.Ch.; Neerincx, M.A.

    2011-01-01

    Research regarding autonomous learning shows that freeplay does not result in optimal learning. Combining scenario-based training with intelligent agent technology off ers the possibility to create autonomous training enriched with automated adaptive support delivered by a director agent. We conduct

  3. Computation Directorate Annual Report 2003

    Energy Technology Data Exchange (ETDEWEB)

    Crawford, D L; McGraw, J R; Ashby, S F; McCoy, M G; Michels, T C; Eltgroth, P G

    2004-03-12

    our employees, whether at work or at home, is a paramount concern. Even as the Directorate meets today's supercomputing requirements, we are preparing for the future. We are investigating open-source cluster technology, the basis of our highly successful Mulitprogrammatic Capability Resource (MCR). Several breakthrough discoveries have resulted from MCR calculations coupled with theory and experiment, prompting Laboratory scientists to demand ever-greater capacity and capability. This demand is being met by a new 23-TF system, Thunder, with architecture modeled on MCR. In preparation for the ''after-next'' computer, we are researching technology even farther out on the horizon--cell-based computers. Assuming that the funding and the technology hold, we will acquire the cell-based machine BlueGene/L within the next 12 months.

  4. Process Analytical Technology-Recent Advances

    OpenAIRE

    Vishal Gupta, N.; S. Prathima; Shashikanth. D; A. Kailash Kumar

    2013-01-01

    Process analytical technologies had been applied to manufacturing processes for decades. Recently, the US Food and Drug Administration (FDA) had re-defined the phrase and implemented into an initiative focusing on improving the several aspects of pharmaceutical industry; European agency for the evaluation of Medicinal products (EMEA) has formed a PAT team in 2003. The PAT initiative was initially intended for traditional pharmaceutical manufacturers, but the FDA’s PAT guidance clearly states ...

  5. Message from Fermilab Director

    CERN Multimedia

    2009-01-01

    With this issue’s message, Fermilab Director Pier Oddone opens a new series of occasional exchanges between CERN and other laboratories world-wide. As part of this exchange, CERN Director-General Rolf Heuer, wrote a message in Tuesday’s edition of Fermilab TodayPerspectivesNothing is more important for our worldwide particle physics community than successfully turning on the LHC later this year. The promise for great discoveries is huge, and many of the plans for our future depend on LHC results. Those of us planning national programmes in anticipation of data from the LHC face formidable challenges to develop future facilities that are complementary to the LHC, whatever the physics discoveries may be. At Fermilab, this has led us to move forcefully with a programme at the intensity frontier, where experiments with neutrinos and rare decays open a complementary window into nature. Our ultimate goal for a unified picture of nat...

  6. Beam director design report

    Energy Technology Data Exchange (ETDEWEB)

    Younger, F.C.

    1986-08-01

    A design and fabrication effort for a beam director is documented. The conceptual design provides for the beam to pass first through a bending and focusing system (or ''achromat''), through a second achromat, through an air-to-vacuum interface (the ''beam window''), and finally through the vernier steering system. Following an initial concept study for a beam director, a prototype permanent magnet 30/sup 0/ beam-bending achromat and prototype vernier steering magnet were designed and built. In volume II, copies are included of the funding instruments, requests for quotations, purchase orders, a complete set of as-built drawings, magnetic measurement reports, the concept design report, and the final report on the design and fabrication project. (LEW)

  7. 8 February 2017 - Sri Lanka Hon. Minister of Science, Technology and Research A. D. S. Premajayantha signing the International Cooperation Agreement concerning Scientific and Technical Cooperation in High-Energy Physics 2017 with CERN Director for International Relations C. Warakaulle.

    CERN Multimedia

    Brice, Maximilien

    2017-01-01

    Were present: Hon. A. D. Susil Premajayantha, Minister of Science, Technology and Research, Democratic Socialist Republic of Sri Lanka; H.E. Mr Ravinatha Aryasinha, Ambassador, Permanent Representative of Sri Lanka to the UN in Geneva; Mrs Samantha Jayasuriya, Deputy Permanent Representative, Permanent Mission of Sri Lanka to the UN in Geneva; Ms Shashika Somaratne, Counsellor, Permanent Mission of Sri Lanka to the UN in Geneva; Mr Gihan Indragupta, Member of Sri Lanka Foreign service and Head of the G15 Secretariat; Ms Dilini Gunasekera, Second Secretary, Permanent Mission of Sri Lanka to the UN in Geneva; Mr Prageeth Herath , Supporting staff, Permanent Mission of Sri Lanka. CERN: Mr Andrzej Charkiewicz, CMS Ressources Manager; Ms Sofia Intoudi, Legal Officer; Dr Rüdiger Voss, Senior Adviser, International Relations; Ms Charlotte Warakaulle, Director for International Relations

  8. Directors: Their duties and powers

    OpenAIRE

    2009-01-01

    Company directors control and direct a company in the interests of its owners (known as members). They also have particular responsibilities under the law and the company’s constitution. A company must have at least two directors. These act together on a board of directors.

  9. Unpacking Pat Parker: Intersections and Revolutions in "Movement in Black".

    Science.gov (United States)

    Washburn, Amy

    2015-01-01

    This article explores Pat Parker's poem "Movement in Black." It examines the ways in which she emblematizes intersectionality and simultaneity as forms of revolution in struggles of self and society. It begins with a theoretical and historical apparatus to contextualize Parker as an artist and activist. Then it offers a literary analysis of the poem, focusing on themes of time and space, marginalization and movement, difference and power, visibility and invisibility, and history and memory. It argues that Parker uses autobiographical writing to fuse personal and political sites of resistance.

  10. Enzyme activity in banana fruits rotted by Botryodiplodia theobromae Pat.

    Directory of Open Access Journals (Sweden)

    Nityananda Chakraborty

    2015-06-01

    Full Text Available Peroxidase and polyphenol oxidase activities in fruits of two cultivars of banana, 'champa' and 'kanthali' rotted by Botryodiplodia theobromae Pat. was studied. The enzymes showed much higher activities in infected than that in uninfected 'tissues. Increase in peroxidase activity was evidently inhibited by cycloheximide. Polyphenol oxidase activity was also inhibited in presence of phenylthiourea and Na-diethyldithiocarbamate more strongly by the former. Increase in activities seemed to be due to increased sytheses of the enzymes. In an in vitro culture, the fungus exhibited some peroxidase but no polyphenoloxidase activity.

  11. Proyecto Almus: Paté de altramuz listo para comer

    OpenAIRE

    ARMENGOL AZNAR, JOSEP

    2016-01-01

    [ES] Este proyecto denominado “Proyecto Almus: paté de altramuces listo para comer” se basa en el proceso de desarrollo de un producto alimentario ecoinnovador mediante la aplicación del proceso de “Design Thinking”. El diseño del producto se completa con el desarrollo de un modelo de negocio empleando el modelo “Canvas”. El objetivo de este trabajo era obtener un producto alimentario que cumpliera con los requisitos del concurso Ecotrophelia, una competición de grupos de estudiantes unive...

  12. The mechanism of patellamide macrocyclization revealed by the characterization of the PatG macrocyclase domain.

    Science.gov (United States)

    Koehnke, Jesko; Bent, Andrew; Houssen, Wael E; Zollman, David; Morawitz, Falk; Shirran, Sally; Vendome, Jeremie; Nneoyiegbe, Ada F; Trembleau, Laurent; Botting, Catherine H; Smith, Margaret C M; Jaspars, Marcel; Naismith, James H

    2012-08-01

    Peptide macrocycles are found in many biologically active natural products. Their versatility, resistance to proteolysis and ability to traverse membranes has made them desirable molecules. Although technologies exist to synthesize such compounds, the full extent of diversity found among natural macrocycles has yet to be achieved synthetically. Cyanobactins are ribosomal peptide macrocycles encompassing an extraordinarily diverse range of ring sizes, amino acids and chemical modifications. We report the structure, biochemical characterization and initial engineering of the PatG macrocyclase domain of Prochloron sp. from the patellamide pathway that catalyzes the macrocyclization of linear peptides. The enzyme contains insertions in the subtilisin fold to allow it to recognize a three-residue signature, bind substrate in a preorganized and unusual conformation, shield an acyl-enzyme intermediate from water and catalyze peptide bond formation. The ability to macrocyclize a broad range of nonactivated substrates has wide biotechnology applications.

  13. The mechanism of patellamide macrocyclization revealed by the characterization of the PatG macrocyclase domain

    Science.gov (United States)

    Koehnke, Jesko; Bent, Andrew; Houssen, Wael E; Zollman, David; Morawitz, Falk; Shirran, Sally; Vendome, Jeremie; Nneoyiegbe, Ada F; Trembleau, Laurent; Botting, Catherine H; Smith, Margaret C M; Jaspars, Marcel; Naismith, James H

    2012-01-01

    Peptide macrocycles are found in many biologically active natural products. Their versatility, resistance to proteolysis and ability to traverse membranes has made them desirable molecules. Although technologies exist to synthesize such compounds, the full extent of diversity found among natural macrocycles has yet to be achieved synthetically. Cyanobactins are ribosomal peptide macrocycles encompassing an extraordinarily diverse range of ring sizes, amino acids and chemical modifications. We report the structure, biochemical characterization and initial engineering of the PatG macrocyclase domain of Prochloron sp. from the patellamide pathway that catalyzes the macrocyclization of linear peptides. The enzyme contains insertions in the subtilisin fold to allow it to recognize a three-residue signature, bind substrate in a preorganized and unusual conformation, shield an acyl-enzyme intermediate from water and catalyze peptide bond formation. The ability to macrocyclize a broad range of nonactivated substrates has wide biotechnology applications. PMID:22796963

  14. Directors General appointed

    CERN Multimedia

    1975-01-01

    At a special session on 21 March, presided over by P. Levaux, the Council of the European Organization for Nuclear Research appointed J . B. Adams and L . Van Hove as Directors General of the Organization for a period of five years beginning 1 January 1976. Dr. Adams will be responsible for the administration of CERN, for the operation of the equipment and services and for the construction of buildings and major equipment. Professor Van Hove will be responsible for the research activities of the Organization.

  15. NSF assistant director for geosciences announces resignation

    Science.gov (United States)

    Zielinki, Sarah

    Margaret Leinen, assistant director for geosciences at the U.S. National Science Foundation, announced on 7 December that she will be leaving NSF in January 2007 to become the chief science officer and vice president of Climos, a new company based in San Francisco, Calif., that plans to develop solutions to reduce greenhouse gases. Leinen will oversee efforts to better understand the planet's carbon cycle to address global climate change issues.Leinen has managed the Directorate for Geosciences since 2000. She also served as vice chair of the U.S. Climate Change Science Program, which coordinates federal climate change research, and as co-chair of the National Science and Technology Council's Joint Committee on Ocean Science and Technology.

  16. 9 April 2013 - Minister for Universities and Science United Kingdom of Great Britain and Northern Ireland D. Willetts in the ATLAS experimental cavern with ATLAS Collaboration Spokesperson D. Charlton and in the LHC tunnel at Point 1 with Beams Department Head P. Collier. Director for Accelerators and Technology S. Myers, Editor at the Communication Group K. Kahle and Beams Department Engineer R. Veness present.

    CERN Multimedia

    Jean-Claude Gadmer

    2013-01-01

    9 April 2013 - Minister for Universities and Science United Kingdom of Great Britain and Northern Ireland D. Willetts in the ATLAS experimental cavern with ATLAS Collaboration Spokesperson D. Charlton and in the LHC tunnel at Point 1 with Beams Department Head P. Collier. Director for Accelerators and Technology S. Myers, Editor at the Communication Group K. Kahle and Beams Department Engineer R. Veness present.

  17. 5 June 2013 - European Union Ambassador to Switzerland and the Principality of Liechtenstein R. Jones in the ATLAS cavern with ATLAS Collaboration Deputy Spokesperson T. Wengler, in the LHC tunnel at Point 1 with Technology Department Head F. Bordry and signing the guest book with Director-General R. Heuer. Head of the EU Projects Office S. Stavrev present.

    CERN Multimedia

    Jean-Claude Gadmer

    2013-01-01

    5 June 2013 - European Union Ambassador to Switzerland and the Principality of Liechtenstein R. Jones in the ATLAS cavern with ATLAS Collaboration Deputy Spokesperson T. Wengler, in the LHC tunnel at Point 1 with Technology Department Head F. Bordry and signing the guest book with Director-General R. Heuer. Head of the EU Projects Office S. Stavrev present.

  18. 17 October 2013 - C. Ashton High Representative of the European Union for Foreign Affairs and Security Policy, Vice-President of the European Commission visiting the ATLAS cavern with ATLAS Collaboration Spokesperson D. Charlton; visiting the LHC tunnel at Point 1 with Technology Department Head F. Bordry and signing the Guest book with CERN Director-General R. Heuer.

    CERN Document Server

    Maximilien Brice

    2013-01-01

    17 October 2013 - C. Ashton High Representative of the European Union for Foreign Affairs and Security Policy, Vice-President of the European Commission visiting the ATLAS cavern with ATLAS Collaboration Spokesperson D. Charlton; visiting the LHC tunnel at Point 1 with Technology Department Head F. Bordry and signing the Guest book with CERN Director-General R. Heuer.

  19. 8 April 2011 - Brazilian Minister of State for Science and Technology A. Mercadante Oliva signing the guest book with CERN Director-General R. Heuer and Head of International Relations F. Pauss; in the ATLAS visitor centre with Collaboration Former Spokesperson P. Jenni; visiting LHC superconducting magnet test hall with J.M. Jimenez.

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    8 April 2011 - Brazilian Minister of State for Science and Technology A. Mercadante Oliva signing the guest book with CERN Director-General R. Heuer and Head of International Relations F. Pauss; in the ATLAS visitor centre with Collaboration Former Spokesperson P. Jenni; visiting LHC superconducting magnet test hall with J.M. Jimenez.

  20. 30th November 2010 - Norwegian Ministry of Government Administration, Reform and Church Affairs State Secretary R. Valle signing the guest book with Head of International Relations F. Pauss and Director for Research and Scientific Computing S. Bertolucci; visiting CERN Computer Centre with Information Technology Department Head F. Hemmer.

    CERN Multimedia

    Maximilien Brice

    2010-01-01

    30th November 2010 - Norwegian Ministry of Government Administration, Reform and Church Affairs State Secretary R. Valle signing the guest book with Head of International Relations F. Pauss and Director for Research and Scientific Computing S. Bertolucci; visiting CERN Computer Centre with Information Technology Department Head F. Hemmer.

  1. 26th August 2010 - World Meteorological Organization Secretary-General M. Jarraud signing the guest book with CERN Director-General R. Heuer and visiting the LHC superconducting magnet test hall with Technology Department Head F. Bordry; throughout accompanied by M. Bona, CERN Relations with International Organisations

    CERN Multimedia

    Maximilien Brice

    2010-01-01

    26th August 2010 - World Meteorological Organization Secretary-General M. Jarraud signing the guest book with CERN Director-General R. Heuer and visiting the LHC superconducting magnet test hall with Technology Department Head F. Bordry; throughout accompanied by M. Bona, CERN Relations with International Organisations

  2. Chinese Commission of Science Technology and Industry for National Defense Senior Vice Minister CHEN Qiufa visiting ALICE experiment on 1st November 2007 with CERN Director-General R. Aymar and Adviser J.-P. Revol. Thursday, 1st and Friday, 2nd November 2007

    CERN Multimedia

    Maximilien Brice

    2007-01-01

    Chinese Commission of Science Technology and Industry for National Defense Senior Vice Minister CHEN Qiufa visiting ALICE experiment on 1st November 2007 with CERN Director-General R. Aymar and Adviser J.-P. Revol. Thursday, 1st and Friday, 2nd November 2007

  3. 21 May 2013 - Slovakian State Secretary, Ministry of Health V. Čislák signing the Guest Book with CERN Director-General R. Heuer; in the LHC tunnel at Point 2 with V. Senaj (Technology Department); in the ALICE experimental cavern with P. Chochula (Physics Department). M. Cirilli (Knowledge Transfer Group) present.

    CERN Multimedia

    Jean-Claude Gadmer

    2013-01-01

    21 May 2013 - Slovakian State Secretary, Ministry of Health V. Čislák signing the Guest Book with CERN Director-General R. Heuer; in the LHC tunnel at Point 2 with V. Senaj (Technology Department); in the ALICE experimental cavern with P. Chochula (Physics Department). M. Cirilli (Knowledge Transfer Group) present.

  4. 6 March 2013 - Committee for Employment and Learning, Northern Ireland Legislative Assembly, United Kingdom of Great Britain and Northern Ireland in the LHC tunnel and visiting the LHCb experiment at LHC Point 8. Director for Accelerators and Technology S. Myers with Vice-Chair T. Buchanan.

    CERN Multimedia

    Anna Pantelia

    2013-01-01

    6 March 2013 - Committee for Employment and Learning, Northern Ireland Legislative Assembly, United Kingdom of Great Britain and Northern Ireland in the LHC tunnel and visiting the LHCb experiment at LHC Point 8. Director for Accelerators and Technology S. Myers with Vice-Chair T. Buchanan.

  5. 22nd September 2010 - Korean Minister of Education, Science and Technology J.-H. Lee signing the guest book and exchanging gifts with CERN Director-General R. Heuer and Head of International Relations F. Pauss; visiting ALICE exhibition with Collaboration Spokesperson J. Schukraft; accompanied throughout by Adviser R. Voss.

    CERN Multimedia

    Teams : M. Brice ; JC Gadmer

    2010-01-01

    22nd September 2010 - Korean Minister of Education, Science and Technology J.-H. Lee signing the guest book and exchanging gifts with CERN Director-General R. Heuer and Head of International Relations F. Pauss; visiting ALICE exhibition with Collaboration Spokesperson J. Schukraft; accompanied throughout by Adviser R. Voss.

  6. 18 February 2013 - Foundation for Polish Science President M. Zylicz signing the guest book with CERN Director for Research and Scientific Computing S. Bertolucci; visiting the ALICE experimental cavern with K. Safarik and L. Graczykowskind LHC tunnel with Technology Department A. Siemko.

    CERN Multimedia

    Samuel Morier-Genoud

    2013-01-01

    18 February 2013 - Foundation for Polish Science President M. Zylicz signing the guest book with CERN Director for Research and Scientific Computing S. Bertolucci; visiting the ALICE experimental cavern with K. Safarik and L. Graczykowskind LHC tunnel with Technology Department A. Siemko.

  7. 18 December 2013 - P. Kron Chairman and Chief Executive Officer of ALSTOM signing the Guest Book with the Director-General R. Heuer and visiting the LHC tunnel at Point 1 with Technology Department Head F. Bordry. Accompanied by P. Fassnacht throughout.

    CERN Document Server

    Jean-Claude Gadmer

    2013-01-01

    18 December 2013 - P. Kron Chairman and Chief Executive Officer of ALSTOM signing the Guest Book with the Director-General R. Heuer and visiting the LHC tunnel at Point 1 with Technology Department Head F. Bordry. Accompanied by P. Fassnacht throughout.

  8. Professor Bakytzhan Abdiraiym Rector of the L. Gumilov Eurasian National University, Astana, Kazakhstan accompanied by Prof. Kairat Kuterbekov, Dr Bekzat Prmantayeva, Dr Kuralay Maksut with the Director-General, Dr Tadeusz Kurtyka, Adviser for Non-Member States, Mrs Julia Andreeva, Department of Information Technologies and Dr Nikolai Zimine, ATLAS Collaboration, Joint Institute for Nuclear Research, Dubna

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    Professor Bakytzhan Abdiraiym Rector of the L. Gumilov Eurasian National University, Astana, Kazakhstan accompanied by Prof. Kairat Kuterbekov, Dr Bekzat Prmantayeva, Dr Kuralay Maksut with the Director-General, Dr Tadeusz Kurtyka, Adviser for Non-Member States, Mrs Julia Andreeva, Department of Information Technologies and Dr Nikolai Zimine, ATLAS Collaboration, Joint Institute for Nuclear Research, Dubna

  9. 1 April 2014 - President of the Parliament of the Principality of Liechtenstein A. Frick and his delegation visiting the LHC tunnel at Point 1 with Technology Department Head J.M. Jiménez and signing the Guest book with CERN Director-General R. Heuer. Deputy Head of International Relations E. Tsesmelis present throughout.

    CERN Document Server

    Pantelia, Anna

    2014-01-01

    1 April 2014 - President of the Parliament of the Principality of Liechtenstein A. Frick and his delegation visiting the LHC tunnel at Point 1 with Technology Department Head J.M. Jiménez and signing the Guest book with CERN Director-General R. Heuer. Deputy Head of International Relations E. Tsesmelis present throughout.

  10. 19 April 2013 - The University of Chicago Vice President for Research and for National Laboratories D. H. Levy signing the guest book with CERN Director for Accelerators and Technology S. Myers; in the LHC tunnel with L. Bottura; throughout accompanied by US CMS J. Butler. Mrs Levy and Mrs Butler took part.

    CERN Multimedia

    Anna Pantelia

    2013-01-01

    19 April 2013 - The University of Chicago Vice President for Research and for National Laboratories D. H. Levy signing the guest book with CERN Director for Accelerators and Technology S. Myers; in the LHC tunnel with L. Bottura; throughout accompanied by US CMS J. Butler. Mrs Levy and Mrs Butler took part.

  11. 24 May 2013 - Rector of the Polish Stanislaw Staszic AGH University of Science and Technology T. Slomka in the LHC tunnel at Point 8 with Senior Polish Staff Member A. Siemko, in LHCb experimental cavern with LHCb Collaboration Spokesperson P. Campana and signing the guest book with Director-General R. Heuer. Adviser for Eastern Europe T. Kurtyka present.

    CERN Multimedia

    Jean-Claude Gadmer

    2013-01-01

    24 May 2013 - Rector of the Polish Stanislaw Staszic AGH University of Science and Technology T. Slomka in the LHC tunnel at Point 8 with Senior Polish Staff Member A. Siemko, in LHCb experimental cavern with LHCb Collaboration Spokesperson P. Campana and signing the guest book with Director-General R. Heuer. Adviser for Eastern Europe T. Kurtyka present.

  12. William Brinkman (centre), Director of the Department of Energy, U.S.A. at the superconducting magnet test hall SM18 with (from left to right) Coordinator for External Relations F. Pauss, Advisor for Non-Member States J. Ellis, J. Strait from Fermilab and Deputy Head of Technology Department L. Rossi on 13 November 2009.

    CERN Multimedia

    Maximilien Brice; SM18

    2009-01-01

    William Brinkman (centre), Director of the Department of Energy, U.S.A. at the superconducting magnet test hall SM18 with (from left to right) Coordinator for External Relations F. Pauss, Advisor for Non-Member States J. Ellis, J. Strait from Fermilab and Deputy Head of Technology Department L. Rossi on 13 November 2009.

  13. 23rd June 2010 - Australian Nuclear Science and Technology Organization Chief Executive Officer A. Paterson signing a Joint Statement of Intent and the guest book with CERN Director-General R. Heuer; in the ATLAS visitor centre and control room with Former Collaboration Spokesperson P. Jenni.

    CERN Document Server

    Maximilien Brice

    2010-01-01

    23rd June 2010 - Australian Nuclear Science and Technology Organization Chief Executive Officer A. Paterson signing a Joint Statement of Intent and the guest book with CERN Director-General R. Heuer; in the ATLAS visitor centre and control room with Former Collaboration Spokesperson P. Jenni.

  14. 17 January 2011 - British (Cambridge) Trustee of the London Science Museum Chair of the Management Committee of the Newton Institute for Mathematical Sciences H. Covington in the LHCB underground experimental area with A. Schopper; signing the guest book with Director for Accelerators and Technology S. Myers; throughout accompanied by R. Veness.

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    17 January 2011 - British (Cambridge) Trustee of the London Science Museum Chair of the Management Committee of the Newton Institute for Mathematical Sciences H. Covington in the LHCB underground experimental area with A. Schopper; signing the guest book with Director for Accelerators and Technology S. Myers; throughout accompanied by R. Veness.

  15. 25 June 2010 - Founder Chairman of the Japanese Science and Technology in Society Forum K. Omi signing the guest book with Head of International Relations F. Pauss, Adviser J. Ellis and Director-General R. Heuer; in the ATLAS visitor centre with Former Collaboration Spokesperson P. Jenni.

    CERN Multimedia

    2010-01-01

    25 June 2010 - Founder Chairman of the Japanese Science and Technology in Society Forum K. Omi signing the guest book with Head of International Relations F. Pauss, Adviser J. Ellis and Director-General R. Heuer; in the ATLAS visitor centre with Former Collaboration Spokesperson P. Jenni.

  16. 19 July 2013 - Chairman of the Policy Committee, European Cancer Organisation, President, European Association for Cancer Research E. Celis visiting the ATLAS experimental cavern with ATLAS Collaboration Deputy Spokesperson, B. Heinemann and signing the Guest Book with Director for Accelerators and Technology S. Myers. Life Sciences Adviser M. Dosanjh present.

    CERN Multimedia

    Anna Pantelia

    2013-01-01

    19 July 2013 - Chairman of the Policy Committee, European Cancer Organisation, President, European Association for Cancer Research E. Celis visiting the ATLAS experimental cavern with ATLAS Collaboration Deputy Spokesperson, B. Heinemann and signing the Guest Book with Director for Accelerators and Technology S. Myers. Life Sciences Adviser M. Dosanjh present.

  17. 17 April 2013 - UK Queen Mary University London Principal S. Gaskell in the ATLAS control room at LHC Point 1, LHC tunnel and ATLAS experimental cavern with Collaboration Spokesperson D. Charlton and signing the guest book with CERN Director for Accelerators and Technology S. Myers.

    CERN Multimedia

    Maximilien Brice

    2013-01-01

    17 April 2013 - UK Queen Mary University London Principal S. Gaskell in the ATLAS control room at LHC Point 1, LHC tunnel and ATLAS experimental cavern with Collaboration Spokesperson D. Charlton and signing the guest book with CERN Director for Accelerators and Technology S. Myers.

  18. 8 April 2013 - Indian Hon'ble Minister for Ministry of Science & Technology and Ministry of Earth Sciences Shri Sudini Jaipal Reddy in the LHC tunnel with K. Foraz, visiting the CMS cavern with Technical Coordinator A. Ball and Former Spokesperson T. Virdee, signing the guest book with Director-General R. Heuer.

    CERN Multimedia

    Samuel Morier-Genoud

    2013-01-01

    8 April 2013 - Indian Hon'ble Minister for Ministry of Science & Technology and Ministry of Earth Sciences Shri Sudini Jaipal Reddy in the LHC tunnel with K. Foraz, visiting the CMS cavern with Technical Coordinator A. Ball and Former Spokesperson T. Virdee, signing the guest book with Director-General R. Heuer.

  19. Magnetic heat pump flow director

    Science.gov (United States)

    Howard, Frank S. (Inventor)

    1995-01-01

    A fluid flow director is disclosed. The director comprises a handle body and combed-teeth extending from one side of the body. The body can be formed of a clear plastic such as acrylic. The director can be used with heat exchangers such as a magnetic heat pump and can minimize the undesired mixing of fluid flows. The types of heat exchangers can encompass both heat pumps and refrigerators. The director can adjust the fluid flow of liquid or gas along desired flow directions. A method of applying the flow director within a magnetic heat pump application is also disclosed where the comb-teeth portions of the director are inserted into the fluid flow paths of the heat pump.

  20. Department Director's Fund for Earthquake Relief

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ On May 30,2008,NSFC Department of Chemical Sciences launched its Director's Fund Emergency Program"Technologies for the collection and analysis of the bacteria and viruses in the air of earthquake stricken areas",which was undertaken by Prof.Zhu Tong and his research group from the Environment and Health Research Center and the College of Environmental Sciences and Engineering of Peking University.

  1. Cooperative Directors: Perspective and Leadership

    OpenAIRE

    Adrian, John L., Jr.; Kiser, Stephen L.

    2000-01-01

    Cooperative directors’ perceptions of their roles, knowledge, and implementation of cooperative principles, business decision making, financial analysis, cooperative law, and division of responsibility with management were analyzed using data from forty-eight agricultural and thirty-one rural electric directors. Directors performed well in these areas with the best performance being related to decision-making scenarios. Self-assessments and performance for capabilities/situational items wer...

  2. Gerald L. Epstein, PhD: director, center for science, technology, and security policy, American Association for the Advancement of Science (AAAS). Interview by Madeline Drexler.

    Science.gov (United States)

    Epstein, Gerald L

    2009-12-01

    Over his entire career, Gerald Epstein has toiled at the nexus of science, technology, and security. From 2003 to 2009, he was Senior Fellow for Science and Security at the Center for Strategic and International Studies Homeland Security Program, where he worked on reducing biological weapons threats, improving national preparedness, and easing potential tensions between the scientific research and national security communities. Epstein came to CSIS from the Institute for Defense Analyses. From 1996 to 2001, he served in the White House Office of Science and Technology Policy. And from 1983 to 1989, and again from 1991 until its demise in 1995, Epstein worked at the Congressional Office of Technology Assessment, where he directed a study on the proliferation of weapons of mass destruction, alongside research on other global security topics. A recognized expert in biological risk reduction, Epstein was actually trained as a physicist, having received SB degrees in physics and electrical engineering from MIT, and a PhD in physics from the University of California at Berkeley. How, then, did he come to study the evolving threat from bioterrorism? "What compelled me about bioterrorism was that it was a stellar example of a topic that would lead to a train wreck between the scientific community and the security community unless they figured out how to work together," he said. "The distance between a laboratory and a very large consequence event is a lot shorter in biology than in any other field. I got into bioterrorism to help make sure that the security community doesn't get so scared of the science that it shuts it down, and that the science community isn't so oblivious of security concerns that it pays no attention to them." Epstein spoke on November 6, 2009, with contributing writer Madeline Drexler, author of Emerging Epidemics: The Menace of New Infections (Penguin, 2009), an updated version of an earlier volume. Drexler holds a visiting appointment at the

  3. Molecular cloning and characterization of oocyte-specific Pat1a in Rana rugosa frogs.

    Science.gov (United States)

    Nakamura, Yoriko; Iwasaki, Takehiro; Umei, Yosuke; Saotome, Kazuhiro; Nakajima, Yukiko; Kitahara, Shoichi; Uno, Yoshinobu; Matsuda, Yoichi; Oike, Akira; Kodama, Maho; Nakamura, Masahisa

    2015-10-01

    The Pat1 gene is expressed in the immature oocytes of Xenopus, and is reportedly involved in regulating the translation of maternal mRNAs required for oocyte-maturation. However, it is still unknown when Pat1a first appears in the differentiating ovary of amphibians. To address this issue, we isolated the full-length Pat1a cDNA from the frog Rana rugosa and examined its expression in the differentiating ovary of this frog. Among eight different tissues examined, the Pat1a mRNA was detectable in only the ovary. When frozen sections from the ovaries of tadpoles at various stages of development were immunostained for Vasa-a germ cell-specific protein-and Pat1a, Vasa-immunopositive signals were observed in all of the germ cells, whereas Pat1a signals were confined to the growing oocytes (50-200 μm in diameter), and absent from small germ cells (<50 μm in diameter). Forty days after testosterone injection into tadpoles to induce female-to-male sex-reversal, Pat1a-immunoreactive oocytes had disappeared completely from the sex-reversed gonad, but Vasa-positive small germ cells persisted. Thus, Pat1a would be a good marker for identifying the sexual status of the sex-reversing gonad in amphibians. In addition, fluorescence in situ hybridization analysis showed Pat1a to have an autosomal locus, suggesting that Pat1a transcription is probably regulated by a tissue-specific transcription factor in R. rugosa.

  4. Object Oriented Programming in Director

    Directory of Open Access Journals (Sweden)

    Marian DARDALA

    2006-01-01

    Full Text Available Director is one of the most popular authoring software. As software for developing multimedia applications, Director is an object oriented programming environment. A very important issue to develop multimedia applications is the designing of their own classes. This paper presents the particular aspects concerning the available facilities offered by Lingo to design classes and to generate objects.

  5. Three directors for one strategy

    CERN Multimedia

    2009-01-01

    Following the interview with the Director General, Rolf-Dieter Heuer, the Bulletin continues its series of interviews with the members of CERN’s new Management team. This week, the Bulletin interviewed the three Directors, who presented their strategies for their respective sectors as a new era begins for CERN.

  6. IT governance guidelines for directors

    CERN Document Server

    Calder, Alan

    2005-01-01

    This important new book – 'IT Governance: Guidelines for Directors' provides directors, executives, managers and professional advisers with clear, pragmatic guidelines for ensuring that IT and the business work together for the same strategic objectives. 

  7. Juan Antonio Rubio appointed as Director-General of CIEMAT

    CERN Multimedia

    2004-01-01

    Juan Antonio Rubio, Head of CERN's ETT unit (Education and Technology Transfer) has been appointed by the Spanish Ministry of Education and Science as the Director General of the Research Centre for Energy, Environment and Technology, CIEMAT. Dr Rubio's career began at the Spanish Nuclear Energy Commission where he held the posts of Investigator, Head of the High Energy Group and Head of Nuclear Physics and High Energy Division. Later, he was named Director of the Department of Basic Investigation and Scientific Director of the CIEMAT. In 1987 he joined CERN as Scientific Adviser to the Director General and Group Leader of the Scientific Assessment Group. Up to now, Dr Rubio has been the Head of the ETT unit, as well as Coordinator for Latin America and Commissioner for the 50th Anniversary of the Organization. He was born on 4 June 1944 in Madrid, and holds a Doctorate in Physical Sciences from the Universidad Complutense de Madrid.

  8. The influence of feeding strategy on growth and rejection of herbage around dung pats and their decomposition

    NARCIS (Netherlands)

    Bosker, W.T.E.; Hoekstra, N.J.; Lantinga, E.A.

    2002-01-01

    Fresh cattle dung from four farms with different feeding strategies was used to create artificial dung pats in a continuously grazed pasture in order to compare the rejection of herbage growing around the pats, the effect on undisturbed herbage growth under cages and pat decomposition. The first far

  9. 绚丽秀美,气势迫人 Pat Metheny/Brad Mehldau 《Metheny Mehldau》

    Institute of Scientific and Technical Information of China (English)

    马其发

    2007-01-01

    <正>爵士吉他高手Pat Metheny的作品通常"兵分两路",一是以Pat Metheny Group集体创作出碟,玩Crossover Jazz或Fusjon为主;另一是以Pat Metheny名义与一些乐坛名宿合作,玩Contemporary Jazz、Folk Jazz和

  10. PAT1 (SLC36A1) shows nuclear localization and affect growth of smooth muscle cells from rats

    DEFF Research Database (Denmark)

    Jensen, Anne; Figueiredo-Larsen, Evan Manuel; Holm, René

    2014-01-01

    the localization and function of PAT1 in smooth muscle cells (SMCs). The PAT1 protein was found in smooth muscles from rat intestine and in the embryonic rat aorta cell line A7r5. Immunolocalization and cellular fractionation studies revealed that the majority of the PAT1 protein located within the cell nucleus...

  11. 28 November 2013 - N. N. Kudryavtsev, Russian Rector of the Moscow Institute of Physics and Technology signing an Agreement and the Guest Book with CERN Director-General R. Heuer; visiting the ATLAS cavern with ATLAS Deputy Spokesperson B. Heinemann and visiting the LHC tunnel at Point 1 with AGH University of Science and Technology A. Erokhin. M. Savino, Physics Department, Joint Institute for Nuclear Research also present.

    CERN Multimedia

    Jean-Claude Gadmer

    2013-01-01

    28 November 2013 - N. N. Kudryavtsev, Russian Rector of the Moscow Institute of Physics and Technology signing an Agreement and the Guest Book with CERN Director-General R. Heuer; visiting the ATLAS cavern with ATLAS Deputy Spokesperson B. Heinemann and visiting the LHC tunnel at Point 1 with AGH University of Science and Technology A. Erokhin. M. Savino, Physics Department, Joint Institute for Nuclear Research also present.

  12. 21 March 2011 - South African Ministry of Science and Technology, Department of Science and Technology (DST) Director General P. Mjwara signing the guest with Head of International Relations F. Pauss and Adviser J. Ellis and ALICE Collaboration Spokesperson P. Giubellino and J. Cleymans; in the CERN control centre with R. Steerenberg; visiting ALICE surface exhibition with P. Giubellino and LHC superconducting magnet test hall with L. Bottura.

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    21 March 2011 - South African Ministry of Science and Technology, Department of Science and Technology (DST) Director General P. Mjwara signing the guest with Head of International Relations F. Pauss and Adviser J. Ellis and ALICE Collaboration Spokesperson P. Giubellino and J. Cleymans; in the CERN control centre with R. Steerenberg; visiting ALICE surface exhibition with P. Giubellino and LHC superconducting magnet test hall with L. Bottura.

  13. Polyamine metabolism is altered in unpollinated parthenocarpic pat-2 tomato ovaries.

    Science.gov (United States)

    Fos, Mariano; Proaño, Karina; Alabadí, David; Nuez, Fernando; Carbonell, Juan; García-Martínez, José L

    2003-01-01

    Facultative parthenocarpy induced by the recessive mutation pat-2 in tomato (Lycopersicon esculentum Mill.) depends on gibberellins (GAs) and is associated with changes in GA content in unpollinated ovaries. Polyamines (PAs) have also been proposed to play a role in early tomato fruit development. We therefore investigated whether PAs are able to induce parthenocarpy and whether the pat-2 mutation alters the content and metabolism of PAs in unpollinated ovaries. Application of putrescine, spermidine, and spermine to wild-type unpollinated tomato ovaries (cv Madrigal [MA/wt]) induced partial parthenocarpy. Parthenocarpic growth of MA/pat-2 (a parthenocarpic near-isogenic line to MA/wt) ovaries was negated by paclobutrazol (GA biosynthesis inhibitor), and this inhibition was counteracted by spermidine. Application of alpha-difluoromethyl-ornithine (-Orn) and/or alpha-difluoromethyl-arginine (-Arg), irreversible inhibitors of the putrescine biosynthesis enzymes Orn decarboxylase (ODC) and Arg decarboxylase, respectively, prevented growth of unpollinated MA/pat-2 ovaries. Alpha-difluoromethyl-Arg inhibition was counteracted by putrescine and GA(3), whereas that of alpha-difluoromethyl-Orn was counteracted by GA(3) but not by putrescine or spermidine. In unpollinated MA/pat-2 ovaries, the content of free spermine was significantly higher than in MA/wt ovaries. ODC activity was higher in pat-2 ovaries than in MA/wt. Transcript levels of genes encoding ODC and spermidine synthase were also higher in MA/pat-2. All together, these results strongly suggest that the parthenocarpic ability of pat-2 mutants depends on elevated PAs levels in unpollinated mutant ovaries, which correlate with an activation of the ODC pathway, probably as a consequence of elevated GA content in unpollinated pat-2 tomato ovaries.

  14. C. elegans PAT-9 is a nuclear zinc finger protein critical for the assembly of muscle attachments

    Directory of Open Access Journals (Sweden)

    Liu Qian

    2012-05-01

    Full Text Available Abstract Background Caenorhabditis elegans sarcomeres have been studied extensively utilizing both forward and reverse genetic techniques to provide insight into muscle development and the mechanisms behind muscle contraction. A previous genetic screen investigating early muscle development produced 13 independent mutant genes exhibiting a Pat (paralyzed and arrested elongation at the two-fold length of embryonic development muscle phenotype. This study reports the identification and characterization of one of those genes, pat-9. Results Positional cloning, reverse genetics, and plasmid rescue experiments were used to identify the predicted C. elegans gene T27B1.2 (recently named ztf-19 as the pat-9 gene. Analysis of pat-9 showed it is expressed early in development and within body wall muscle lineages, consistent with a role in muscle development and producing a Pat phenotype. However, unlike most of the other known Pat gene family members, which encode structural components of muscle attachment sites, PAT-9 is an exclusively nuclear protein. Analysis of the predicted PAT-9 amino acid sequence identified one putative nuclear localization domain and three C2H2 zinc finger domains. Both immunocytochemistry and PAT-9::GFP fusion expression confirm that PAT-9 is primarily a nuclear protein and chromatin immunoprecipitation (ChIP experiments showed that PAT-9 is present on certain gene promoters. Conclusions We have shown that the T27B1.2 gene is pat-9. Considering the Pat-9 mutant phenotype shows severely disrupted muscle attachment sites despite PAT-9 being a nuclear zinc finger protein and not a structural component of muscle attachment sites, we propose that PAT-9 likely functions in the regulation of gene expression for some necessary structural or regulatory component(s of the muscle attachment sites.

  15. Another Phoenix VA director leaves

    Directory of Open Access Journals (Sweden)

    Robbins RA

    2016-08-01

    Full Text Available No abstract available. Article truncated after 150 words. The Arizona Republic reports that the director at the Phoenix VA Medical Center, Deborah Amdur, will retire after only 9 months for health reasons (1. Amdur will be replaced by Barbara Fallen, director of the VA Loma Linda Healthcare System. Fallen will be interim director until a permanent replacement for Amdur can be found. This is the fifth hospital director since former Director Sharon Helman was removed in mid-2014 amid the nationwide veterans health-care scandal that was first exposed at the Phoenix VA. The Veterans Integrated Service Network (VISN in Gilbert, which oversees the VA Medical Center in Arizona, New Mexico and West Texas has also been through a series of 4 directors since Susan Bowers retired under pressure in the wake of the VA scandal. Marie Weldon, current acting regional director, also oversees the Los Angeles-based VA Desert Pacific Healthcare System. Weldon described Fallen as “an experienced leader who ...

  16. Corporate governance: remedying and ratifying directors' breaches

    OpenAIRE

    Worthington, Sarah

    2000-01-01

    Extent to which company may relax scope and content of directors' duties, whether it can exonerate directors who default on their duties and whether it can ratify actions of defaulting directors and determine remedy for breach of duty.

  17. 7 CFR 29.17 - Director.

    Science.gov (United States)

    2010-01-01

    ... of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... INSPECTION Regulations Definitions § 29.17 Director. Director or Acting Director, Tobacco Division, Agricultural Marketing Service, U.S. Department of Agriculture....

  18. Are You a Codependent Director?

    Science.gov (United States)

    Broussard, Anne M.

    1992-01-01

    Codependency and its effect on the professional lives of directors of early childhood programs is described. Characteristics of codependent administrators, the need for confrontation of codependent behaviors, and suggested sources of help for codependency are discussed. (LB)

  19. Are You a Codependent Director?

    Science.gov (United States)

    Broussard, Anne M.

    1992-01-01

    Codependency and its effect on the professional lives of directors of early childhood programs is described. Characteristics of codependent administrators, the need for confrontation of codependent behaviors, and suggested sources of help for codependency are discussed. (LB)

  20. Heterogeneous distributions of Escherichia coli O157 within naturally infected bovine faecal pats.

    Science.gov (United States)

    Robinson, Susan E; Brown, Patrick E; John Wright, E; Bennett, Malcolm; Hart, C Anthony; French, Nigel P

    2005-03-15

    Escherichia coli O157 is an important human pathogen for which cattle are considered a reservoir. This paper describes and models the variation in counts of E. coli O157 that exists within individual bovine faecal pats. The presence and concentration of E. coli O157 in faecal samples was determined using a combination of direct spiral plating followed by a more sensitive isolation procedure. The data were modelled using multilevel random effect models, in which the random effects were allowed to be correlated to allow for the fact that pooled and individual samples come from the same pat. Up to a two log difference in the concentration of E. coli O157 was demonstrated in samples from different areas within a faecal pat. Pooling of individual samples from throughout the faecal pat and processing it as one composite sample allows this heterogeneity to be overcome.

  1. Pat Adams水彩作品在Zabriskie画廊展出

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    近期,美国水彩画家Pat Adams创作于1954年至2004年间的38幅水彩作品在Zabriskie画廊展出。Pat Adams的水彩画善于采用原始的色彩、重叠的样式和弯曲的形态,在抽象的空间中营造一种流动的感觉。

  2. Sertraline inhibits the transport of PAT1 substrates in vivo and in vitro

    DEFF Research Database (Denmark)

    Nielsen, Carsten Uhd; Frølund, Sidsel Balsgaard; Abdulhadi, S

    2013-01-01

    Intestinal nutrient transporters may mediate the uptake of drugs. The aim of this study was to investigate whether sertraline interacts with the intestinal proton-coupled amino acid transporter 1 PAT1 (SLC36A1).......Intestinal nutrient transporters may mediate the uptake of drugs. The aim of this study was to investigate whether sertraline interacts with the intestinal proton-coupled amino acid transporter 1 PAT1 (SLC36A1)....

  3. GeoPAT: A toolbox for pattern-based information retrieval from large geospatial databases

    Science.gov (United States)

    Jasiewicz, Jarosław; Netzel, Paweł; Stepinski, Tomasz

    2015-07-01

    Geospatial Pattern Analysis Toolbox (GeoPAT) is a collection of GRASS GIS modules for carrying out pattern-based geospatial analysis of images and other spatial datasets. The need for pattern-based analysis arises when images/rasters contain rich spatial information either because of their very high resolution or their very large spatial extent. Elementary units of pattern-based analysis are scenes - patches of surface consisting of a complex arrangement of individual pixels (patterns). GeoPAT modules implement popular GIS algorithms, such as query, overlay, and segmentation, to operate on the grid of scenes. To achieve these capabilities GeoPAT includes a library of scene signatures - compact numerical descriptors of patterns, and a library of distance functions - providing numerical means of assessing dissimilarity between scenes. Ancillary GeoPAT modules use these functions to construct a grid of scenes or to assign signatures to individual scenes having regular or irregular geometries. Thus GeoPAT combines knowledge retrieval from patterns with mapping tasks within a single integrated GIS environment. GeoPAT is designed to identify and analyze complex, highly generalized classes in spatial datasets. Examples include distinguishing between different styles of urban settlements using VHR images, delineating different landscape types in land cover maps, and mapping physiographic units from DEM. The concept of pattern-based spatial analysis is explained and the roles of all modules and functions are described. A case study example pertaining to delineation of landscape types in a subregion of NLCD is given. Performance evaluation is included to highlight GeoPAT's applicability to very large datasets. The GeoPAT toolbox is available for download from

  4. 2011 Computation Directorate Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Crawford, D L

    2012-04-11

    From its founding in 1952 until today, Lawrence Livermore National Laboratory (LLNL) has made significant strategic investments to develop high performance computing (HPC) and its application to national security and basic science. Now, 60 years later, the Computation Directorate and its myriad resources and capabilities have become a key enabler for LLNL programs and an integral part of the effort to support our nation's nuclear deterrent and, more broadly, national security. In addition, the technological innovation HPC makes possible is seen as vital to the nation's economic vitality. LLNL, along with other national laboratories, is working to make supercomputing capabilities and expertise available to industry to boost the nation's global competitiveness. LLNL is on the brink of an exciting milestone with the 2012 deployment of Sequoia, the National Nuclear Security Administration's (NNSA's) 20-petaFLOP/s resource that will apply uncertainty quantification to weapons science. Sequoia will bring LLNL's total computing power to more than 23 petaFLOP/s-all brought to bear on basic science and national security needs. The computing systems at LLNL provide game-changing capabilities. Sequoia and other next-generation platforms will enable predictive simulation in the coming decade and leverage industry trends, such as massively parallel and multicore processors, to run petascale applications. Efficient petascale computing necessitates refining accuracy in materials property data, improving models for known physical processes, identifying and then modeling for missing physics, quantifying uncertainty, and enhancing the performance of complex models and algorithms in macroscale simulation codes. Nearly 15 years ago, NNSA's Accelerated Strategic Computing Initiative (ASCI), now called the Advanced Simulation and Computing (ASC) Program, was the critical element needed to shift from test-based confidence to science-based confidence

  5. Computation Directorate 2007 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Henson, V E; Guse, J A

    2008-03-06

    If there is a single word that both characterized 2007 and dominated the thoughts and actions of many Laboratory employees throughout the year, it is transition. Transition refers to the major shift that took place on October 1, when the University of California relinquished management responsibility for Lawrence Livermore National Laboratory (LLNL), and Lawrence Livermore National Security, LLC (LLNS), became the new Laboratory management contractor for the Department of Energy's (DOE's) National Nuclear Security Administration (NNSA). In the 55 years under the University of California, LLNL amassed an extraordinary record of significant accomplishments, clever inventions, and momentous contributions in the service of protecting the nation. This legacy provides the new organization with a built-in history, a tradition of excellence, and a solid set of core competencies from which to build the future. I am proud to note that in the nearly seven years I have had the privilege of leading the Computation Directorate, our talented and dedicated staff has made far-reaching contributions to the legacy and tradition we passed on to LLNS. Our place among the world's leaders in high-performance computing, algorithmic research and development, applications, and information technology (IT) services and support is solid. I am especially gratified to report that through all the transition turmoil, and it has been considerable, the Computation Directorate continues to produce remarkable achievements. Our most important asset--the talented, skilled, and creative people who work in Computation--has continued a long-standing Laboratory tradition of delivering cutting-edge science even in the face of adversity. The scope of those achievements is breathtaking, and in 2007, our accomplishments span an amazing range of topics. From making an important contribution to a Nobel Prize-winning effort to creating tools that can detect malicious codes embedded in commercial

  6. 12 CFR 918.4 - Directors' expenses.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Directors' expenses. 918.4 Section 918.4 Banks... BANK DIRECTOR COMPENSATION AND EXPENSES § 918.4 Directors' expenses. Each Bank may pay its directors... connection with the performance of their official duties as are payable to senior officers of the Bank...

  7. 3rd August 2010 - CEO Siemens Healthcare Sector, Chief Technology Officer, Head of Corporate Technology, Member of Siemens AG Managing Board, Germany, H. Requardt, signing the guest book with CERN Director-General R. Heuer

    CERN Multimedia

    Maximilien Brice

    2010-01-01

    CERN-HI-1008148 11: H. von Dewitz in the ATLAS Visitor centre with Collaboration member M. Hauschild (left) and Former IT Department Head W. von Rüden (right) CERN-HI-1008148 18 : Head of Innovation and Systems Projects, Siemens Healthcare Sector O. Heid (left) in the ATLAS Visitor centre with Collaboration member M. Hauschild. CERN-HI-1008148: in the ATLAS visitor centre, from left to right: Former IT Department Head W. von Rüden; ATLAS Collaboration P. Mättig; CEO Siemens Healthcare Sector, Chief Technology Officer, Head of Corporate Technology, Member of Siemens AG Managing Board, Germany, H. Requardt; Head of Innovation and Systems Projects, Siemens Healthcare Sector O. Heid; H. von Dewitz; ATLAS Collaboration member M. Hauschild.

  8. The emergency department medical director.

    Science.gov (United States)

    Mayer, T A

    1987-02-01

    This article has presented an overview of the duties, responsibilities, and management roles of the emergency department Medical Director, a position that can be among the most challenging, stimulating, and exciting in medicine. However, prior to accepting a position as an Emergency Department medical director, one should have a clear understanding of what the job entails. Careful discussions with the hospital administration, medical staff, nursing personnel, and staff emergency physicians should be undertaken to learn the perceptions of these people and expectations of the position. Once the job has been accepted, using the roles, responsibilities, and duties detailed herein may be of benefit--but should always be applied with good judgment, tactful cooperation, and common sense. Finally, it should not be surprising to a medical director to find, as Spinoza did many years ago, that the excellent thing he aspires to are as difficult as they are rare.

  9. Characterization of the plasmid encoded virulence region pat-1 of phytopathogenic Clavibacter michiganensis subsp. michiganensis.

    Science.gov (United States)

    Dreier, J; Meletzus, D; Eichenlaub, R

    1997-03-01

    The tomato pathogen Clavibacter michiganensis subsp. michiganensis NCPPB382, causing bacterial wilt and canker, harbors two plasmids, pCM1 (27.5 kb) and pCM2 (72 kb), carrying genes involved in virulence. The region of plasmid pCM2 encoding the pathogenicity locus pat-1 was mapped by deletion analysis and complementation studies to a 1.5-kb Bg/II/SmaI DNA fragment. Introduction of the pat-1 region into endophytic, plasmid-free isolates of C. michiganensis subsp. michiganensis converted these bacteria into virulent pathogens. Based on the nucleotide sequence of the pat-1 region, an open reading frame (ORF1) can be predicted, coding for a protein of 280 amino acids and 29.7 kDa with homology to serine proteases. Introduction of a frame-shift mutation in ORF1 leads to a loss of the pathogenic phenotype. Northern (RNA) hybridizations identified an 1.5-knt transcript of the pat-1 structural gene. The site of transcription initiation was mapped by primer extension and a typical -10/-35 region was located with significant homology to the consensus Escherichia coli sigma 70 and Bacillus subtilis sigma 43 promoters. Downstream of the pat-1 structural gene, a peculiar repetitive sequence motif (pat-1rep) is located, consisting of 20 direct tandem repeats preceded by a run of 14 guanosine residues. DNA sequences homologous to pat-1rep were isolated and characterized from four virulent C. michiganensis subsp. michiganensis strains exhibiting a high extent of structural conservation. The deletion of this repetitive sequence reduced virulence significantly but did not lead to a complete loss of the virulence phenotype.

  10. The gene pat-2, which induces natural parthenocarpy, alters the gibberellin content in unpollinated tomato ovaries.

    Science.gov (United States)

    Fos, M; Nuez, F; García-Martínez, J L

    2000-02-01

    We investigated the role of gibberellins (GAs) in the effect of pat-2, a recessive mutation that induces facultative parthenocarpic fruit development in tomato (Lycopersicon esculentum Mill.) using near-isogenic lines with two different genetic backgrounds. Unpollinated wild-type Madrigal (MA/wt) and Cuarenteno (CU/wt) ovaries degenerated, but GA(3) application induced parthenocarpic fruit growth. On the contrary, parthenocarpic growth of MA/pat-2 and CU/pat-2 fruits, which occurs in the absence of pollination and hormone application, was not affected by GA(3). Pollinated MA/wt and parthenocarpic MA/pat-2 ovary development was negated by paclobutrazol, and this inhibitory effect was counteracted by GA(3). The main GAs of the early-13-hydroxylation pathway (GA(1), GA(3), GA(8), GA(19), GA(20), GA(29), GA(44), GA(53), and, tentatively, GA(81)) and two GAs of the non-13-hydroxylation pathway (GA(9) and GA(34)) were identified in MA/wt ovaries by gas chromatography-selected ion monitoring. GAs were quantified in unpollinated ovaries at flower bud, pre-anthesis, and anthesis. In unpollinated MA/pat-2 and CU/pat-2 ovaries, the GA(20) content was much higher (up to 160 times higher) and the GA(19) content was lower than in the corresponding non-parthenocarpic ovaries. The application of an inhibitor of 2-oxoglutarate-dependent dioxygenases suggested that GA(20) is not active per se. The pat-2 mutation may increase GA 20-oxidase activity in unpollinated ovaries, leading to a higher synthesis of GA(20), the precursor of an active GA.

  11. Enfermedad diarreica aguda por Escherichia coli patógenas en Colombia

    Science.gov (United States)

    Gómez-Duarte, Oscar G.

    2014-01-01

    Resumen Las cepas de E. coli patógenas intestinales son causas importantes de la enfermedad diarreica aguda (EDA) en niños menores de 5 años en América Latina, África y Asia y están asociadas a alta mortalidad en niños en las comunidades más pobres de África y el Sudeste Asiático. Estudios sobre el papel de las E. coli patógenas intestinales en la EDA infantil en Colombia y otros países de América Latina son limitados debido a la carencia de ensayos para detección de estos patógenos en los laboratorios clínicos de centros de salud. Estudios recientes han reportado la detección de E. coli patógenas intestinales en Colombia, siendo la E. coli enterotoxigénica la cepa más frecuentemente asociada a diarrea en niños menores de 5 años. Otros patógenos detectados en estos pacientes incluyen las E. coli enteroagregativa, enteropatógena, productora de toxina Shiga, y de adherencia difusa. Con base en estudios que reportan la presencia de E. coli productora de toxina Shiga y E. coli enteroagregativa en carnes y vegetales en supermercados, se cree que productos alimentarios contaminados contribuyen a la transmisión de estos patógenos y a la infección del huésped susceptible. Más estudios son necesarios para evaluar los mecanismos de transmisión, el impacto en la epidemiologia de la EDA, y las pautas de manejo y prevención de estos patógenos que afectan la población pediátrica en Colombia. PMID:25491457

  12. Vigabatrin absorption is mediated via the proton-coupled amino acid transporter PAT1 – in vitro and in vivo

    DEFF Research Database (Denmark)

    Nøhr, Martha Kampp; Juul, Rasmus Vestergaard; Hansen, Steen Honore'

    2013-01-01

    proton coupled amino acid transporter PAT1, however the actual transport mechanisms involved in transepithelial absorption have not been clarified. The aim of the study was to investigate whether the transepithelial absorption of vigabatrin is mediated by PAT1 – in vitro as well as in vivo. Methods...... the pharmacokinetic profile of vigabatrin with an apparent prolonged absorption of vigabatrin. Conclusions Transport of vigabatrin across Caco-2 cell monolayers was polarized in the lumen-to-blood directions, dependent on an acidic pH in the lumen compartment and inhibited by PAT1-ligands. This indicated that PAT1.......4. The transepithelial transport across Caco-2 cell monolayers was polarized in the lumen-to-blood direction in the presence of a proton gradient. The presence of PAT1-ligands significantly decreased the permeability of vigabatrin across Caco-2 cell monolayers. In Sprague Dawley rats the presence of PAT1-ligands altered...

  13. Pump used as a turbine (PAT) with flow control - Part 1: General; Petites centrales hydrauliques. Pompe fonctionnant en turbine avec reglage du debit (Pat-Francis). 1ere partie: presentation generale

    Energy Technology Data Exchange (ETDEWEB)

    Chapallaz, J.-M.

    2007-02-15

    This first part of a final report for the Swiss Federal Office of Energy (SFOE) discusses the use of a pump equipped with variable guide vanes, similar to a Francis turbine. This first part of a four-part article describes the PAT-Francis project in general. The turbine was realised by removing the existing spiral casing from a standard pump and replacing it with a guide vane system with a new spiral. General topics on the use of pumps as turbines are discussed and the characteristic curves and operational limits of a PAT are examined. The proposed concept for a PAT with variable flow, or PAT-Francis, is presented.

  14. Hybrid modeling for quality by design and PAT-benefits and challenges of applications in biopharmaceutical industry.

    Science.gov (United States)

    von Stosch, Moritz; Davy, Steven; Francois, Kjell; Galvanauskas, Vytautas; Hamelink, Jan-Martijn; Luebbert, Andreas; Mayer, Martin; Oliveira, Rui; O'Kennedy, Ronan; Rice, Paul; Glassey, Jarka

    2014-06-01

    This report highlights the drivers, challenges, and enablers of the hybrid modeling applications in biopharmaceutical industry. It is a summary of an expert panel discussion of European academics and industrialists with relevant scientific and engineering backgrounds. Hybrid modeling is viewed in its broader sense, namely as the integration of different knowledge sources in form of parametric and nonparametric models into a hybrid semi-parametric model, for instance the integration of fundamental and data-driven models. A brief description of the current state-of-the-art and industrial uptake of the methodology is provided. The report concludes with a number of recommendations to facilitate further developments and a wider industrial application of this modeling approach. These recommendations are limited to further exploiting the benefits of this methodology within process analytical technology (PAT) applications in biopharmaceutical industry. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. Technical scheme and corresponding experiment for the PAT performance of a lasercom using an integrated test-bed

    Science.gov (United States)

    Sun, Jianfeng; Liu, Liren; Wang, Lijuan; Luan, Zhu; Liu, De'an; Xu, Nan; Zhong, Xianghong

    2007-09-01

    Recent successful demonstrations of laser communications have demonstrated the feasibility of some of the key aspects of this technology. The demonstrations can not success without the full-up ground test and validation. So an integrate test-bed was build in build to test the technical parameters and to verify the working performance for the optical pointing, acquisition and tracking (PAT) of various inter-satellite lasercom terminals. In this paper, we detail the test technical scheme (TTS) and the corresponding experiments. The integrate test-bed is a high quality optical system that will measure the key characteristics of lasercom terminals, such as point error, tracking error, acquisition possibility etc.. The test-bed can operate over the relative wavelength range. Through quantitative tests, the terminal could be optimized base on the test results.

  16. Substrate specificity and functional characterisation of the H+/amino acid transporter rat PAT2 (Slc36a2)

    OpenAIRE

    Kennedy, David J.; Gatfield, Kelly M.; Winpenny, John P; Ganapathy, Vadivel; Thwaites, David T.

    2004-01-01

    Functional characteristics and substrate specificity of the rat proton-coupled amino acid transporter 2 (rat PAT2 (rPAT2)) were determined following expression in Xenopus laevis oocytes using radiolabelled uptake measurements, competition experiments and measurements of substrate-evoked current using the two-electrode voltage-clamp technique. The aim of the investigation was to determine the structural requirements and structural limitations of potential substrates for rPAT2.Amino (and imino)...

  17. Diagnostic accuracy of PAT-POPS and ManChEWS for admissions of children from the emergency department

    OpenAIRE

    Cotterill, Sarah; Rowland, Andrew G; Kelly, Jacqueline; Lees, Helen; Kamara, Mohammed

    2016-01-01

    Background The Pennine Acute Trust (PAT) Paediatric Observation Priority Score (PAT-POPS) is a specific emergency department (ED) physiological and observational aggregate scoring system, with scores of 0–18. A higher score indicates greater likelihood of admission. The Manchester Children's Early Warning System (ManChEWS) assesses six physiological observations to create a trigger score, classified as Green, Amber or Red. Methods Prospectively collected data were used to calculate PAT-POPS a...

  18. The Protein Acetyltransferase PatZ from Escherichia coli Is Regulated by Autoacetylation-induced Oligomerization.

    Science.gov (United States)

    de Diego Puente, Teresa; Gallego-Jara, Julia; Castaño-Cerezo, Sara; Bernal Sánchez, Vicente; Fernández Espín, Vanesa; García de la Torre, José; Manjón Rubio, Arturo; Cánovas Díaz, Manuel

    2015-09-18

    Lysine acetylation is an important post-translational modification in the metabolic regulation of both prokaryotes and eukaryotes. In Escherichia coli, PatZ (formerly YfiQ) is the only known acetyltransferase protein and is responsible for acetyl-CoA synthetase acetylation. In this study, we demonstrated PatZ-positive cooperativity in response to acetyl-CoA and the regulation of acetyl-CoA synthetase activity by the acetylation level. Furthermore, functional analysis of an E809A mutant showed that the conserved glutamate residue is not relevant for the PatZ catalytic mechanism. Biophysical studies demonstrated that PatZ is a stable tetramer in solution and is transformed to its octameric form by autoacetylation. Moreover, this modification is reversed by the sirtuin CobB. Finally, an in silico PatZ tetramerization model based on hydrophobic and electrostatic interactions is proposed and validated by three-dimensional hydrodynamic analysis. These data reveal, for the first time, the structural regulation of an acetyltransferase by autoacetylation in a prokaryotic organism.

  19. An Academic Library Director's Bestiary

    Science.gov (United States)

    McKay, Richard

    2012-01-01

    The article examines some of the non-routine challenges that an academic library director can expect to deal with during his or her career. Each challenge is discussed in a paragraph or two, beginning by characterizing the challenge as an animal that serves as a metaphor for unusual but nonetheless important conditions that can, sooner or later,…

  20. International Honor for YCIS Director

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    @@ The Director of Yew Chung International Schools(YCIS),Dr.Betty Chan Po-King,has received an international honor for her pioneering work in early childhood education and advocacy for excellence in all levels of education.On May 16,Dr.Chan was awarded the honorary degree of Doctor of Humane Letters from the University of Illinois at Urbana-Champaign(UIUC).

  1. A novel gene amplification causes upregulation of the PatAB ABC transporter and fluoroquinolone resistance in Streptococcus pneumoniae.

    Science.gov (United States)

    Baylay, Alison J; Ivens, Alasdair; Piddock, Laura J V

    2015-01-01

    Overexpression of the ABC transporter genes patA and patB confers efflux-mediated fluoroquinolone resistance in Streptococcus pneumoniae and is also linked to pneumococcal stress responses. Although upregulation of patAB has been observed in many laboratory mutants and clinical isolates, the regulatory mechanisms controlling expression of these genes are unknown. In this study, we aimed to identify the cause of high-level constitutive overexpression of patAB in M184, a multidrug-resistant mutant of S. pneumoniae R6. Using a whole-genome transformation and sequencing approach, we identified a novel duplication of a 9.2-kb region of the M184 genome which included the patAB genes. This duplication did not affect growth and was semistable with a low segregation rate. The expression levels of patAB in M184 were much higher than those that could be fully explained by doubling of the gene dosage alone, and inactivation of the first copy of patA had no effect on multidrug resistance. Using a green fluorescent protein reporter system, increased patAB expression was ascribed to transcriptional read-through from a tRNA gene upstream of the second copy of patAB. This is the first report of a large genomic duplication causing antibiotic resistance in S. pneumoniae and also of a genomic duplication causing antibiotic resistance by a promoter switching mechanism.

  2. Energy and Environment Directorate Status Report March 2006

    Energy Technology Data Exchange (ETDEWEB)

    Long, J S

    2006-02-21

    March 6-9, 2006. The following sections describe the overall directorate structure, the Associate Director's vision for the future, structure and activities of the department and the four major programs, followed by appendices with information about publications, patents, and awards. An additional appendix provides information on the performance objectives used in the performance-based management system that is part of the UC contract to operate LLNL for DOE. The E&E Directorate contributes mainly to performance object 5, ''Enhance and nurture a strong science, engineering, and technology base in support of national security strategic objectives''. This appendix is included because information from the review committee's report may be included in the LLNL Science and Technology Office's annual report on how LLNL and its directorates meet the performance objectives. We anticipate that the science talks (mainly from the Center for Accelerator Mass Spectrometry) and the science poster session will help the committee assess the E&E Directorate's overall ability to support the scientific needs of LLNL.

  3. 16 CFR 0.10 - Office of the Executive Director.

    Science.gov (United States)

    2010-01-01

    ..., financial management, information technology, and human resources. ... on strategic planning and assessing the management and resource implications of any proposed action... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Office of the Executive Director. 0.10...

  4. Director's Discretionary Fund Report for Fiscal Year 1997

    Science.gov (United States)

    1998-01-01

    This technical memorandum contains brief technical papers describing research and technology development programs sponsored by the Ames Research Center Director's Discretionary Fund during fiscal year 1997 (October 1996 through September 1997). Appendices provide administrative information for each of the sponsored research programs.

  5. Directors's Discretionary Fund Report For Fiscal Year 1995

    Science.gov (United States)

    1996-01-01

    This technical memorandum contains brief technical papers describing research and technology development programs sponsored by the Ames Research Center Director's Discretionary Fund during the fiscal year 1995 (October 1994 through September 1995). An appendix provides administrative information for each of the sponsored research programs.

  6. Director's discretionary fund report for fiscal year 1994

    Science.gov (United States)

    1995-01-01

    This technical memorandum contains brief technical papers describing research and technology development programs sponsored by the Ames Research Center Director's Discretionary Fund during fiscal year 1991 (October 1993 through September 1994). An appendix provides administrative information for each of the sponsored research programs.

  7. Prof. Zhu Zuoyan Met with Director General of ANR

    Institute of Scientific and Technical Information of China (English)

    Fan Yingjie; Lu Rongkai

    2007-01-01

    @@ On Feb. 2, 2007, Prof. Zhu Zuoyan, Vice President of NSFC met with Ms. Jacqueline Lecourtier, Director General of the French National Research Agency (Agence Nationale de la Recherche, ANR) and Mr.Bernard Belloc, the Science and Technology Counselor of the French Embassy in China.

  8. Enfermedad diarreica aguda por Escherichia coli patógenas en Colombia

    OpenAIRE

    Gómez-Duarte, Oscar G.

    2014-01-01

    Las cepas de E. coli patógenas intestinales son causas importantes de la enfermedad diarreica aguda (EDA) en niños menores de 5 años en América Latina, África y Asia y están asociadas a alta mortalidad en niños en las comunidades más pobres de África y el Sudeste Asiático. Estudios sobre el papel de las E. coli patógenas intestinales en la EDA infantil en Colombia y otros países de América Latina son limitados debido a la carencia de ensayos para detección de estos patógenos en los laboratori...

  9. 29 September 2015 - Vice-President of the Government of Spain S. Sáenz de Santamaría in the ATLAS visitor centre, the Synchrocyclotron, the Data Centre visit point and the LHC magnet facility with CERN Director-General R. Heuer and Technology Department Head J.M. Jiménez.

    CERN Multimedia

    Bennett, Sophia Elizabeth

    2015-01-01

    Were also present from Spain: Sra. Carmen Vela, Secretaria de Estado de Investigación, Desarrollo e Innovación, Sr. D. Bernardo de Sicart Escoda Embajador de España en Berna, Sra. Da Ana Menéndez Pérez, Embajadora Representante Permanente de España ante Naciones Unidas y OOII con sede en Ginebra, Sra. Da María Pico Directora del Gabinete de la Vicepresidenta and Sr. D. Miguel Temboury Redondo Subsecretario de Economía y Competitividad. And from CERN: Dr Maria Alandes Pradillo, Information Technology Department, Dr Maria Barroso-Lopez Deputy Group Leader, IT-PES, Dr Frédérick Bordry, Director of Accelerators and Technology, Dr Borja Fernandez Adiego Engineering Department, Prof. Maria Jose Garcia Borge ISOLDE Collaboration Spokesperson, Dr Fabiola Gianotti Director-General elect 2016-2020, Mr Frédéric Hemmer Information Technology Department Head, Prof. Mario Martinez, Spanish Scientific Delegate to CERN Council Mr Guillermo Merino Fernandez, Technology Department Mr Lluis Miralles, General Infrast...

  10. 22 August 2014 - Members of the International Business Council of the World Economic Forum led by Managing Director and Member of the Managing Board P. Rösler

    CERN Multimedia

    Gadmer, Jean-Claude

    2014-01-01

    Visiting the LHC tunnel at point 5 with Director-General R. Heuer, Director of Accelerators and Technology F. Bordry, Head of International Relations R. Voss and Deputy Head of International Relations E. Tsesmelis

  11. Assessment of family psychosocial functioning in survivors of pediatric cancer using the PAT2.0.

    Science.gov (United States)

    Gilleland, Jordan; Reed-Knight, Bonney; Brand, Sarah; Griffin, Anya; Wasilewski-Masker, Karen; Meacham, Lillian; Mertens, Ann

    2013-09-01

    This study aimed to examine clinical validity and utility of a screening measure for familial psychosocial risk, the Psychosocial Assessment Tool 2.0 (PAT2.0), among pediatric cancer survivors participating in long-term survivorship care. Caregivers (N=79) completed the PAT2.0 during their child's survivorship appointment. Caregivers also reported on family engagement in outpatient mental health treatment. Medical records were reviewed for treatment history and oncology provider initiated psychology consults. The internal consistency of the PAT2.0 total score in this survivorship sample was strong. Psychology was consulted by the oncology provider to see 53% of participant families, and families seen by psychology had significantly higher PAT2.0 total scores than families without psychology consults. PAT2.0 total scores and corresponding subscales were higher for patients, parents, and siblings enrolled in outpatient mental health services since treatment completion. Results were consistent with psychosocial risk categories presented within the Pediatric Psychosocial Preventative Health Model. Fifty-one percent of families presenting for survivorship care scored in the "universal" category, 34% scored in the "targeted" category, and 15% scored in the "clinical" category. Data indicate that the overall proportions of families experiencing "universal", "targeted", and "clinical" levels of familial distress may be constant from the time of diagnosis into survivorship care. Overall, the PAT2.0 demonstrated strong psychometric properties among survivors of pediatric cancer and shows promise as a psychosocial screening measure to facilitate more effective family support in survivorship care. Copyright © 2013 John Wiley & Sons, Ltd.

  12. Identification of presynaptic serotonin autoreceptors using a new ligand: 3H-PAT.

    Science.gov (United States)

    Gozlan, H; El Mestikawy, S; Pichat, L; Glowinski, J; Hamon, M

    Binding studies with appropriate labelled ligands have revealed the existence of two types of serotonin (5-HT) receptor, 5-HT1 and 5-HT2, in the central nervous system of mammals. The 5-HT1 type is characterized by a higher affinity for agonists than for antagonists, whereas the 5-HT2 type binds preferentially to antagonists. However, neither of these receptor types apparently corresponds to the presynaptic autoreceptor controlling 5-HT release. In an attempt to identify the presynaptic autoreceptor directly, we synthesized the tritiated derivative of 8-hydroxy-2-(di-n-propylamino) tetralin (PAT), a new tetralin derivative with potent 5-HT agonist properties and carried out binding studies with rat brain membranes. As we report here, in the hippocampus, the properties of 3H-PAT binding sites correspond closely to those of 5-HT1 sites. In contrast, in the striatum, 3H-PAT binding sites exhibit a subcellular distribution and pharmacological characteristics usually associated with presynaptic autoreceptors. Furthermore, a marked loss of 3H-PAT binding sites occurs in the striatum (but not in the hippocampus) after the selective degeneration of serotoninergic fibres in 5,7-hydroxytryptamine (5,7-HT)-treated rats. Conversely, the sprouting of additional 5-HT terminals in the brain stem of adult rats treated at birth with 5,7-HT is associated with an increased density of 3H-PAT binding sites in this region. 3H-PAT thus seems to be a useful ligand for studying the biochemical and pharmacological characteristics of presynaptic autoreceptors in selected regions of rat brain.

  13. Good modeling practice for PAT applications: propagation of input uncertainty and sensitivity analysis.

    Science.gov (United States)

    Sin, Gürkan; Gernaey, Krist V; Lantz, Anna Eliasson

    2009-01-01

    The uncertainty and sensitivity analysis are evaluated for their usefulness as part of the model-building within Process Analytical Technology applications. A mechanistic model describing a batch cultivation of Streptomyces coelicolor for antibiotic production was used as case study. The input uncertainty resulting from assumptions of the model was propagated using the Monte Carlo procedure to estimate the output uncertainty. The results showed that significant uncertainty exists in the model outputs. Moreover the uncertainty in the biomass, glucose, ammonium and base-consumption were found low compared to the large uncertainty observed in the antibiotic and off-gas CO(2) predictions. The output uncertainty was observed to be lower during the exponential growth phase, while higher in the stationary and death phases - meaning the model describes some periods better than others. To understand which input parameters are responsible for the output uncertainty, three sensitivity methods (Standardized Regression Coefficients, Morris and differential analysis) were evaluated and compared. The results from these methods were mostly in agreement with each other and revealed that only few parameters (about 10) out of a total 56 were mainly responsible for the output uncertainty. Among these significant parameters, one finds parameters related to fermentation characteristics such as biomass metabolism, chemical equilibria and mass-transfer. Overall the uncertainty and sensitivity analysis are found promising for helping to build reliable mechanistic models and to interpret the model outputs properly. These tools make part of good modeling practice, which can contribute to successful PAT applications for increased process understanding, operation and control purposes.

  14. 2011 Computation Directorate Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Crawford, D L

    2012-04-11

    From its founding in 1952 until today, Lawrence Livermore National Laboratory (LLNL) has made significant strategic investments to develop high performance computing (HPC) and its application to national security and basic science. Now, 60 years later, the Computation Directorate and its myriad resources and capabilities have become a key enabler for LLNL programs and an integral part of the effort to support our nation's nuclear deterrent and, more broadly, national security. In addition, the technological innovation HPC makes possible is seen as vital to the nation's economic vitality. LLNL, along with other national laboratories, is working to make supercomputing capabilities and expertise available to industry to boost the nation's global competitiveness. LLNL is on the brink of an exciting milestone with the 2012 deployment of Sequoia, the National Nuclear Security Administration's (NNSA's) 20-petaFLOP/s resource that will apply uncertainty quantification to weapons science. Sequoia will bring LLNL's total computing power to more than 23 petaFLOP/s-all brought to bear on basic science and national security needs. The computing systems at LLNL provide game-changing capabilities. Sequoia and other next-generation platforms will enable predictive simulation in the coming decade and leverage industry trends, such as massively parallel and multicore processors, to run petascale applications. Efficient petascale computing necessitates refining accuracy in materials property data, improving models for known physical processes, identifying and then modeling for missing physics, quantifying uncertainty, and enhancing the performance of complex models and algorithms in macroscale simulation codes. Nearly 15 years ago, NNSA's Accelerated Strategic Computing Initiative (ASCI), now called the Advanced Simulation and Computing (ASC) Program, was the critical element needed to shift from test-based confidence to science-based confidence

  15. Dispersion and Transport of Cryptosporidium Oocysts from Fecal Pats under Simulated Rainfall Events

    OpenAIRE

    Davies, Cheryl M.; Ferguson, Christobel M.; Kaucner, Christine; Krogh, Martin; Altavilla, Nanda; Deere, Daniel A.; Nicholas J. Ashbolt

    2004-01-01

    The dispersion and initial transport of Cryptosporidium oocysts from fecal pats were investigated during artificial rainfall events on intact soil blocks (1,500 by 900 by 300 mm). Rainfall events of 55 mm h−1 for 30 min and 25 mm h−1 for 180 min were applied to soil plots with artificial fecal pats seeded with approximately 107 oocysts. The soil plots were divided in two, with one side devoid of vegetation and the other left with natural vegetation cover. Each combination of event intensity a...

  16. Synchronized fission yeast meiosis using an ATP analog-sensitive Pat1 protein kinase

    OpenAIRE

    Cipak, Lubos; Polakova, Silvia; Hyppa, Randy W.; Smith, Gerald R.; Gregan, Juraj

    2014-01-01

    Synchronous cultures are often indispensable for studying meiosis. Here, we present an optimized protocol for induction of synchronous meiosis in the fission yeast Schizosaccharomyces pombe. Chemical inactivation of an ATP analog-sensitive form of the Pat1 kinase (pat1-as2) by adding the ATP-analog 1-NM-PP1 in G1-arrested cells allows induction of synchronous meiosis at optimal temperature (25 °C). Importantly, this protocol eliminates detrimental effects of elevated temperature (34 °C) which...

  17. The effects of PAT on the Savannah River ecosystem, particularly fisheries

    Energy Technology Data Exchange (ETDEWEB)

    Patrick, R.

    1994-03-01

    The main purpose of this study was to determine whether or not the pre-startup activities at K-Reactor, i.e., Power Ascension Testing (PAT), have caused damage because of temperature rises in the Savannah River. Therefore, the biological studies were mainly aimed at providing information as to changes that might cause the damage of the fish population, and to other important organisms in the ecosystem. To determine if deleterious effects had occurred, one had to review the past studies to determine the condition and diversity of aquatic life before these PAT studies started. Therefore old reports were reviewed and a current study made in 1992.

  18. Computation Directorate 2007 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Henson, V E; Guse, J A

    2008-03-06

    If there is a single word that both characterized 2007 and dominated the thoughts and actions of many Laboratory employees throughout the year, it is transition. Transition refers to the major shift that took place on October 1, when the University of California relinquished management responsibility for Lawrence Livermore National Laboratory (LLNL), and Lawrence Livermore National Security, LLC (LLNS), became the new Laboratory management contractor for the Department of Energy's (DOE's) National Nuclear Security Administration (NNSA). In the 55 years under the University of California, LLNL amassed an extraordinary record of significant accomplishments, clever inventions, and momentous contributions in the service of protecting the nation. This legacy provides the new organization with a built-in history, a tradition of excellence, and a solid set of core competencies from which to build the future. I am proud to note that in the nearly seven years I have had the privilege of leading the Computation Directorate, our talented and dedicated staff has made far-reaching contributions to the legacy and tradition we passed on to LLNS. Our place among the world's leaders in high-performance computing, algorithmic research and development, applications, and information technology (IT) services and support is solid. I am especially gratified to report that through all the transition turmoil, and it has been considerable, the Computation Directorate continues to produce remarkable achievements. Our most important asset--the talented, skilled, and creative people who work in Computation--has continued a long-standing Laboratory tradition of delivering cutting-edge science even in the face of adversity. The scope of those achievements is breathtaking, and in 2007, our accomplishments span an amazing range of topics. From making an important contribution to a Nobel Prize-winning effort to creating tools that can detect malicious codes embedded in commercial

  19. Mycobacterium chelonae y Mycobacterium abscessus: patógenos emergentes

    Directory of Open Access Journals (Sweden)

    Mónica M. Ortegón

    1996-09-01

    Full Text Available Mycobacterium chelonae es el nombre correcto para la micobacteria aislada en 1903 de los pulmones enfermos de una tortuga marina. En una especie distinta de Mycobacterium fo/tuitum, aislado de ranas en 1905, y de Mycobacterium abscessus, considerado actualmente como una subespecie de M chelonae. Estas tres especies son las únicas patógenas para el hombre dentro del grupo de micobacterias ambientales o atipicas, de crecimiento rápido, las cuales se caracterizan por formar colonias en cultivo en menos de siete días. Son agentes etiológicos de nódulos y abscesos cutáneos, localizados y diseminados, de lesiones postoperatorias, usualmente en la cicatriz quirúrgica, de lesiones pulmonares y de linfadenitis granulomatosa, de osteomielitis y de queratitis, entre otras. Las lesiones cutáneas y de los tejidos blandos son las más frecuentes y resultan generalmente de la inoculación traumática de esta micobacteria. Histopatológicamente, los nódulos y abscesos muestran un proceso inflamatorio, supurativo y granulomatoso, mixto, en el que en la cuarta parte de los casos pueden demostrarse conglomerados de bacilos ácido alcohol resistentes, que tienden a estar situados en una vacuola en el centro del absceso. En Colombia, se han descrito tres brotes de abscesos subcutáneos producidos por bacterias ambientales, secundarios a la aplicación de inyecciones contaminadas con el germen causal: en 1981, en Bucaramanga, luego de la aplicación de la vacuna contra la fiebre amarilla, en 50 personas, la mayoría niños; en 1989, en Medellin, por la inyección subcutánea de alergenos, en 13 personas; y, en 1993, en varias ciudades de la costa atlántica, luego de aplicaciones subcutáneas de xilocaína, como tratamiento bionergético, en 297 pacientes. Existen otros informes aislados de casos posttraumáticos.La enfermedad diseminada por micobacterias de rápido crecimiento, se presenta en pacientes inmunosuprimidos. En la biopsia, predominan los

  20. Identification of homologues to the pathogenicity factor Pat-1, a putative serine protease of Clavibacter michiganensis subsp. michiganensis.

    Science.gov (United States)

    Burger, Annette; Gräfen, Ines; Engemann, Jutta; Niermann, Erik; Pieper, Martina; Kirchner, Oliver; Gartemann, Karl-Heinz; Eichenlaub, Rudolf

    2005-01-01

    Hybridization of Clavibacter michiganensis subsp. michiganensis total DNA against the pathogenicity gene pat-1 indicated the presence of pat-1 homologous nucleotide sequences on the chromosome and on plasmid pCM2. Isolation of the corresponding DNA fragments and nucleotide sequence determination showed that there are three pat-1 homologous genes: chpA (chromosome) and phpA and phpB (plasmid pCM2). The gene products share common characteristics, i.e. a signal sequence for Sec-dependent secretion, a serine protease motif, and six cysteine residues at conserved positions. Gene chpA located on the chromosome is a pseudogene since it contains a translational stop codon after 97 of 280 amino acids. In contrast to pat-1, cloning of the plasmid encoded homologs phpA and phpB into the avirulent plasmid free Cmm strain CMM100 did not result in a virulent phenotype. So far, no proteolytic activity could be demonstrated for Pat-1, however, site specific mutagenesis of pat-1 showed that the serine residue in the motif GDSGG is required for the virulent phenotype of pat-1 and thus Pat-1 could be a functional protease.

  1. 5 CFR 2638.506 - Director's recommendation.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Director's recommendation. 2638.506... Cases Involving Individual Executive Agency Employees § 2638.506 Director's recommendation. (a) Where... employee is the head of an agency, the Director shall make any such recommendation to the President and...

  2. 12 CFR 1261.4 - Director eligibility.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Director eligibility. 1261.4 Section 1261.4 Banks and Banking FEDERAL HOUSING FINANCE AGENCY FEDERAL HOME LOAN BANKS FEDERAL HOME LOAN BANK DIRECTORS Federal Home Loan Bank Boards of Directors: Eligibility and Elections § 1261.4...

  3. 45 CFR 1700.5 - Executive Director.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Executive Director. 1700.5 Section 1700.5 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE ORGANIZATION AND FUNCTIONS § 1700.5 Executive Director. (a) The Executive Director...

  4. Integration of Leadership Styles of School Director

    Science.gov (United States)

    Pavlovic, Nebojsa; Oljaca, Milka; Kostovic, Svetlana

    2012-01-01

    Management style can be defined as a special behavior of directors in the work process that affects the performance in an organization, in this case-school. Management style has two related meanings: first is behavior of directors to employees, second is directors' approach in school regarding management, participation of employees in decision…

  5. 3rd May 2009 - Japanese Minister of State for Science and Technology Policy, Food Safety, Minister of Consumer Affairs, Minister of Space Policy S. Noda, visiting ATLAS experimental area, LHC tunnel and CERN Control Centre with CERN Director-General R. Heuer, Collaboration Spokesperson F. Gianotti and Beams Department Head P. Collier.

    CERN Multimedia

    Maximilien Brice

    2009-01-01

    090506101-08: signature of the guest book and exchange of gifts; 090506109 + 46-64: Japanese Ambassador to the United Nations Office S. Kitajima, Japanese Minister of State for Science and Technology Policy, Food Safety, Minister of Consumer Affairs, Minister of Space Policy S. Noda, CERN Director-General R. Heuer, Non Member-State relations Adviser J. Ellis and ATLAS Collaboration Spokesperson F. Gianotti visiting the LHC tunnel at Point 1; 090506110-11 + 28-45: Japanese Minister of State for Science and Technology Policy, Food Safety, Minister of Consumer Affairs, Minister of Space Policy S. Noda and his delegation visiting ATLAS experimental area with CERN Japanese users and Management; 090506112 + 86-94: Japanese Minister of State for Science and Technology Policy, Food Safety, Minister of Consumer Affairs, Minister of Space Policy S. Noda, CERN Director-General R. Heuer and Japanese users in front of an LHC superconducting magnet; sLHC Project Leader also present. 090506113-19: Arrival of Japanese Min...

  6. Design and Fabrication of Cryostat Interface and Electronics for High Performance Antimatter Trap (HI-PAT)

    Science.gov (United States)

    Smith, Gerald A.

    1999-01-01

    Included in Appendix I to this report is a complete set of design and assembly schematics for the high vacuum inner trap assembly, cryostat interfaces and electronic components for the MSFC HI-PAT. Also included in the final report are summaries of vacuum tests, and electronic tests performed upon completion of the assembly.

  7. Evaluation of the EndoPAT as a Tool to Assess Endothelial Function

    Directory of Open Access Journals (Sweden)

    M. Moerland

    2012-01-01

    Endothelial function was stable over a longer period of time in renally impaired patients (coefficient of variation 13%. Endothelial function in renally impaired and type 2 diabetic patients was not decreased compared to healthy volunteers (2.9±1.4 and 1.8±0.3, resp., versus 1.8±0.5, P>0.05. The EndoPAT did not detect an effect of robust interventions on endothelial function in healthy volunteers (glucose load: change from baseline 0.08±0.50, 95% confidence interval −0.44 to 0.60; smoking: change from baseline 0.49±0.92, 95% confidence interval −0.47 to 1.46. This suggests that at present the EndoPAT might not be suitable to assess (changes in endothelial function in early-phase clinical pharmacology studies. Endothelial function as measured by the EndoPAT could be physiologically different from endothelial function as measured by conventional techniques. This should be investigated carefully before the EndoPAT can be considered a useful tool in drug development or clinical practice.

  8. Investigating Trauma in Narrating World War I: A Psychoanalytical Reading of Pat Barker's "Regeneration"

    Science.gov (United States)

    Sadjadi, Bakhtiar; Esmkhani, Farnaz

    2016-01-01

    The present paper seeks to critically read Pat Barker's "Regeneration" in terms of Cathy Caruth's psychoanalytic study of trauma. This analysis attempts to trace the concepts of latency, post-traumatic stress disorders, traumatic memory, and trauma in Barker's novel in order to explore how trauma and history are interrelated in the…

  9. Draft Genome Sequence of the Beer Spoilage Bacterium Megasphaera cerevisiae Strain PAT 1T

    OpenAIRE

    Kutumbaka, Kirthi K.; Pasmowitz, Joshua; Mategko, James; Reyes, Dindo; Friedrich, Alex; Han, Sukkyun; Martens-Habbena, Willm; Neal-McKinney, Jason; Janagama, Harish K.; Nadala, Cesar; Samadpour, Mansour

    2015-01-01

    The genus Megasphaera harbors important spoilage organisms that cause beer spoilage by producing off flavors, undesirable aroma, and turbidity. Megasphaera cerevisiae is mainly found in nonpasteurized low-alcohol beer. In this study, we report the draft genome of the type strain of the genus, M. cerevisiae strain PAT 1T.

  10. Patógenos introducidos al Perú en post larvas de Litopenaeus vannamei importadas

    Directory of Open Access Journals (Sweden)

    Mervin Guevara

    2012-11-01

    Full Text Available El comercio internacional de animales acuáticos es uno de los factores más importantes en la introducción involuntaria de patógenos a una región libre de estos. Los patógenos introducidos han sido causa de enormes pérdidas económicas en organismos bajo cultivo y daños ecológicos en poblaciones silvestres. En este trabajo, utilizando la técnica de la PCR se analizaron postlarvas de Litopenaeus vannamei importadas desde Ecuador para ser utilizada en los cultivos de langostinos en Tumbes. La finalidad fue detectar patógenos como el virus de la mancha blanca (WSV, virus de la cabeza amarilla (YHV, virus de la necrosis hipodérmica y hematopoyética infecciosa (IHHNV, Baculovirus penaei (BP, virus del síndrome de Taura (TSV y la bacteria de la hepatopancreatitis necrotizante (NHPB. Se analizaron 177 muestras de postlarvas en el año 2009 y 274 en el 2010. En el año 2009 se encontraron cuatro patógenos infecciosos en las postlarvas analizadas, siendo más frecuente el IHHNV (9,60%. En el año 2010 la frecuencia de aparición de postlarvas infectadas con IHHNV fue mayor (16,79%. Tanto en el 2009 como en el 2010 se encontraron postlarvas positivas a NHPB, BP y TSV

  11. The Political Use of Mythic Discourse: Prophetic Interpretation in Pat Robertson's Presidential Campaign.

    Science.gov (United States)

    O'Leary, Stephen; McFarland, Michael

    1989-01-01

    Studies the development of a political ideology that draws on the resources of myth. Analyzes how Pat Robertson's concepts of apocalyptic fulfillment provided an ideological basis for his 1988 presidential campaign, but resulted in significant rhetorical problems. Finds that the transformation in Robertson's apocalyptic vision stemmed from his…

  12. You Say You Want a Revolution: An Interview with Pat Brown: e1000560

    National Research Council Canada - National Science Library

    Jane Gitschier

    2009-01-01

      Pat (Image 1) is most frequently associated with the invention of microarrays and their use in studying gene expression, and he should be familiar to the readers of PLoS as a driving force behind open-access journals...

  13. Synchronized fission yeast meiosis using an ATP analog-sensitive Pat1 protein kinase.

    Science.gov (United States)

    Cipak, Lubos; Polakova, Silvia; Hyppa, Randy W; Smith, Gerald R; Gregan, Juraj

    2014-01-01

    Synchronous cultures are often indispensable for studying meiosis. Here we present an optimized protocol for induction of synchronous meiosis in the fission yeast Schizosaccharomyces pombe. Chemical inactivation of an ATP analog-sensitive form of the Pat1 kinase (pat1-as2) by adding the ATP analog 1-NM-PP1 in G1-arrested cells allows the induction of synchronous meiosis at optimal temperature (25°C). Importantly, this protocol eliminates detrimental effects of elevated temperature (34°C), which is required to inactivate the commonly used temperature-sensitive Pat1 kinase mutant (pat1-114). The addition of the mat-Pc gene to a mat1-M strain further improves chromosome segregation and spore viability. Thus, our protocol offers highly synchronous meiosis at optimal temperature, with most characteristics similar to those of wild-type meiosis. The synchronization protocol can be completed in 5 d (not including strain production, which may take as long as 2 or 3 months).

  14. Advanced retorting, microwave assisted thermal sterilization (MATS), and pressure assisted thermal sterilization (PATS) to process meat products.

    Science.gov (United States)

    Barbosa-Cánovas, Gustavo V; Medina-Meza, Ilce; Candoğan, Kezban; Bermúdez-Aguirre, Daniela

    2014-11-01

    Conventional thermal processes have been very reliable in offering safe sterilized meat products, but some of those products are of questionable overall quality. Flavor, aroma, and texture, among other attributes, are significantly affected during such processes. To improve those quality attributes, alternative approaches to sterilizing meat and meat products have been explored in the last few years. Most of the new strategies for sterilizing meat products rely on using thermal approaches, but in a more efficient way than in conventional methods. Some of these emerging technologies have proven to be reliable and have been formally approved by regulatory agencies such as the FDA. Additional work needs to be done in order for these technologies to be fully adopted by the food industry and to optimize their use. Some of these emerging technologies for sterilizing meat include pressure assisted thermal sterilization (PATS), microwaves, and advanced retorting. This review deals with fundamental and applied aspects of these new and very promising approaches to sterilization of meat products. Copyright © 2014 Elsevier Ltd. All rights reserved.

  15. On the avifauna of the upper Patía Valley, Southwestern Colombia On the avifauna of the upper Patía Valley, Southwestern Colombia

    OpenAIRE

    Haffer Jürgen

    1986-01-01

    The bird fauna of the isolated arid Andean valley of the upper río Patia, southwestern Colombia, resembles that of the Cauca Valley to the north.  The most prominent faunal element are widely distributed nonforest birds of the Tropical Zone which entered the Andean valleys of Colombia from the Caribbean lowlands to the north. The relations between the upper Patía fauna and the nonforest fauna of western Ecuador to the south are very restricted (e.g. Veniliornis callonotus). Montane species of...

  16. AISLAMIENTO Y CARACTERIZACIÓN MORFOLÓGICA DE Rosellinia pepo Pat. EN PLANTAS DE MACADAMIA ISOLATION AND MORPHOLOGICAL CHARACTERIZATION OF Rosellinia pepo Pat. IN MACADAMIA PLANTS

    Directory of Open Access Journals (Sweden)

    Carmen Eliana Realpe Ortiz

    2006-12-01

    Full Text Available El hongo Rosellinia pepo Pat., causante de la llaga estrellada, se considera uno de los principales problemas fitosanitarios de la macadamia por ocasionar la muerte de la planta en su etapa productiva. Debido a que no existe una metodología de aislamiento confiable que asegure la recuperación del hongo con un porcentaje mínimo de contaminación y los estudios relacionados con este patógeno son escasos se planteó una investigación con el fin de perfeccionar una metodología de aislamiento y realizar algunas caracterizaciones morfológicas de este patógeno. La nueva metodología permitió obtener aislamientos con un 91,26% de pureza del hongo. La tasa de crecimiento fue de 4,68 mm día-1. Las colonias son de color blanco y apariencia algodonosa en su inicio, pero a medida que envejece el micelio toma un color café o negro y su apariencia se torna quebradiza. La observación de micelio blanco en forma de estrella en el lado interior del medio sintético permite diferenciarlo de otras especies como R. bunodes. Las mediciones microscópicas de los hinchamientos piriformes presentaron en promedio 106,4mm de largo y 75,3mm de ancho. Este trabajo también permitió determinar el nivel de inóculo infectivo.The fungus Rosellinia pepo Pat, the causal agent of star gall, is considered to be a main phytosanitary problem to the Macademia tree by causing the death of the tree while in its productive stage. Because no reliable isolation method exists that assures recovery of the mushroom with a minimum percentage of contamination and studies of this pathogen are scarce. This study was conducted to perfect an isolation methodology and permit some morphological characterizations of this pathogen. The new methodology allowed isolations with 91,26% purity of mushroom to be obtained. The rate of growth was 4,68 mm day-1. The colonies were of white color and cottony appearance in the beginning, but as the micelio aged it assumed a brown or black color and a

  17. Francisco Miranda, Director de Colciencias.

    Directory of Open Access Journals (Sweden)

    Efraím Otero Ruiz

    2006-09-01

    De su desempeño en Sussex (universidad distinguida mundialmente por sus estudios sobre desarrollo tecnológico, transferencia de tecnología y administración de proyectos se recibieron siempre los mejores informes, que lo colocaron en el alto nivel de los latinoamericanos ilustres que han pasado larga o brevemente por dicho claustro, como Máximo Halty-Carrere del Uruguay, Francisco Sagasti del Perú o Fernando Chaparro de Colombia. Con ese bagaje regresó al país donde fue designado como Director Administrativo del Centro Internacional de Entrenamiento e Investigación Médica (CIDEIM de Cali, cargo que ocupó de 1992 a 2002; y al terminar ese decenio fue nombrado por la Junta Directiva como Director Ejecutivo, cargo que ocupó hasta su designación en COLCIENCIAS. En Cali ha ocupado también distinguidas posiciones, tales como Miembro del Consejo Directivo de la Fundación Planeta Valle y del Consejo de Internacionalización de la Universidad Javeriana en esa ciudad...

  18. Family psychosocial risk screening guided by the Pediatric Psychosocial Preventative Health Model (PPPHM) using the Psychosocial Assessment Tool (PAT).

    Science.gov (United States)

    Kazak, Anne E; Schneider, Stephanie; Didonato, Stephen; Pai, Ahna L H

    2015-05-01

    Although families of children with cancer and other serious medical conditions have documented psychosocial needs, the systematic identification of needs and delivery of evidence-based care remain challenges. Screening for multifaceted family psychosocial risk is a means by which psychosocial treatment needs for pediatric patients and their families can be identified in an effective and inclusive manner. The Pediatric Psychosocial Preventative Health Model (PPPHM) is a model that can guide systematic assessment of family psychosocial risk. The Psychosocial Assessment Tool (PAT) is a brief parent report screener of psychosocial risk based on the PPPHM that can be used for families of infants through adolescents. The PPPHM and the PAT are described in this paper, along with a summary of data supporting systematic risk assessment. The PPPHM outlines three tiers of family psychosocial risk - Universal (low), Targeted (medium), and Clinical (high). The PAT is a validated measure of psychosocial risk. Scores on the PAT, derived from multiple sites and disease conditions, map on to the PPPHM with indications that one-half to two-thirds of families score at the Universal level of risk based on the PAT. The PAT is a unique screener of psychosocial risk, both in terms of its breadth and underlying model (PPPHM), and its length and format. As an example of a means by which families can be screened early in the treatment process, PAT scores and corresponding PPPHM levels can provide direction for the delivery of evidence-based psychosocial care.

  19. Energy Saving in a Water Supply Network by Coupling a Pump and a Pump As Turbine (PAT) in a Turbopump

    OpenAIRE

    Armando Carravetta; Lauro Antipodi; Umberto Golia; Oreste Fecarotta

    2017-01-01

    The management of a water distribution network (WDN) is performed by valve and pump control, to regulate both the pressure and the discharge between certain limits. The energy that is usually merely dissipated by valves can instead be converted and used to partially supply the pumping stations. Pumps used as turbines (PAT) can be used in order to both reduce pressure and recover energy, with proven economic benefits. The direct coupling of the PAT shaft with the pump shaft in a PAT-pump turbo...

  20. Institutional directors and board compensation: Spanish evidence

    Directory of Open Access Journals (Sweden)

    Felix López-Iturriaga

    2015-07-01

    Full Text Available We address the influence of directors who represent institutional investors in three aspects of board compensation policies: level of compensation, composition, and performance sensitivity. We differentiate pressure-sensitive directors (i.e., with business links and pressure-resistant directors (i.e., without business links. Our results show that pressure-resistant directors decrease total board compensation and its fixed proportion, whereas they increase the variable proportion of total remuneration and the pay-for-performance sensitivity. By contrast, pressure-sensitive directors offer the opposite results. These findings are consistent with the view that institutional investors are not a homogeneous group and that pressure-resistant directors fulfill a more thorough monitoring role.

  1. Director general presentation to personnel

    CERN Multimedia

    2016-01-01

    Dear Colleagues, Many important discussions are scheduled for the upcoming Council Week (13-17 June) on topics including the Medium-Term Plan, the Pension Fund and other matters of great relevance to us.   I would therefore like to share the main outcome of the week with you and I invite you to join me and the Directors in the Main Auditorium at 10 a.m. on Thursday 23 June. The meeting will last about one hour and a webcast will also be available. Best regards, Fabiola Gianotti DG presentation to personnel Thursday 23 June at 10 am Main Auditorium Retransmission in Council Chamber, IT Auditorium, Kjell Jonhsen Auditorium, Prevessin 864-1-C02 Webcast on cern.ch/webcast More information on the event page.

  2. Study of data analysis methods in functional connectivity photoacoustic tomography (fcPAT)

    Science.gov (United States)

    Khodaee, Afsoon; Nasiriavanaki, Mohammadreza

    2017-03-01

    Resting-state functional connectivity (RSFC) is a method to monitor the health of the brain and find out abnormalities in brain networks. Recently functional connectivity photoacoustic tomography (fcPAT) has been used to study RSFC in the mouse brain. The current method of RSFC data analysis is called "seed-based". This method is not data-driven, and involves user intervention. Alternative signal processing approaches, such as singular value decomposition (SVD) and independent component analysis (ICA), will be explored to complement and cross validate the seed-based approach, possibly substituting them for the seed-based method. The methods are implemented and applied on the fcPAT data of a mouse brain.

  3. 爵士吉他大师Pat Metheny设备谈

    Institute of Scientific and Technical Information of China (English)

    小勇

    2004-01-01

    <正> 还是一个十几岁的孩子的时候,Pat Metheny就已经用他的方式改写了许多爵士教材。许多年龄大他一倍的乐手都来学习他改编的教材。几十年来,他使人感觉到异样的热情和旺盛的艺术青春,在他的乐队《Pat MethenyBand》专辑销量百万张的同时,他还和许多不同风格的艺术家合作,包括Gary Burton、Ornette Coleman、Jim Hall、Charlie Haden、Dave Holland、Derek、Bailey等等。他的风格涉及之广是无人能及的、可以用老少皆宜来形容。

  4. PAT-1 safety analysis report addendum author responses to request for additional information.

    Energy Technology Data Exchange (ETDEWEB)

    Weiner, Ruth F.; Schmale, David T.; Kalan, Robert J.; Akin, Lili A.; Miller, David Russell; Knorovsky, Gerald Albert; Yoshimura, Richard Hiroyuki; Lopez, Carlos; Harding, David Cameron; Jones, Perry L.; Morrow, Charles W.

    2010-09-01

    The Plutonium Air Transportable Package, Model PAT-1, is certified under Title 10, Code of Federal Regulations Part 71 by the U.S. Nuclear Regulatory Commission (NRC) per Certificate of Compliance (CoC) USA/0361B(U)F-96 (currently Revision 9). The National Nuclear Security Administration (NNSA) submitted SAND Report SAND2009-5822 to NRC that documented the incorporation of plutonium (Pu) metal as a new payload for the PAT-1 package. NRC responded with a Request for Additional Information (RAI), identifying information needed in connection with its review of the application. The purpose of this SAND report is to provide the authors responses to each RAI. SAND Report SAND2010-6106 containing the proposed changes to the Addendum is provided separately.

  5. PAT-2 (Plutonium Air-Transportable Model 2) safety analysis report

    Energy Technology Data Exchange (ETDEWEB)

    Andersen, J.A.; Davis, E.J.; Duffey, T.A.; Dupree, S.A.; George, O.L. Jr.; Ortiz, Z.

    1981-07-01

    The PAT-2 package is designed for the safe transport of plutonium and/or uranium in small quantities. The PAT-2 package is resistant to severe accidents, including that of a high-speed jet aircraft crash, and is designed to withstand such environments as extreme impact, crushing, puncturing and slashing loads, severe hydrocarbon-fueled fires, and deep underwater immersion, with no escape of contents. The package meets the requirements of 10 CFR 71 for Fissile Class I packages with a cargo of 15 grams of Pu-239, or other isotopic forms described herein, not to exceed 2 watts of thermal activity. This SAR presents design and oprational information including evaluations and analyses, test results, operating procedures, maintenance, and quality assurance information.

  6. Pump Application as Hydraulic Turbine – Pump as Turbine (PaT)

    OpenAIRE

    Rusovs, D

    2009-01-01

    The paper considers pump operation as hydraulic turbine with purpose to produce mechanical power from liquid flow. The Francis hydraulic turbine was selected for comparison with centrifugal pump in reverse operation. Turbine and centrifugal pump velocity triangles were considered with purpose to evaluate PaT efficiency. Shape of impeller blades for turbine and pumps was analysed. Specific speed calculation is carried out with purpose to obtain similarity in pump and turbine description. For ...

  7. Quantifying beetle-mediated effects on gas fluxes from dung pats.

    Directory of Open Access Journals (Sweden)

    Atte Penttilä

    Full Text Available Agriculture is one of the largest contributors of the anthropogenic greenhouse gases (GHGs responsible for global warming. Measurements of gas fluxes from dung pats suggest that dung is a source of GHGs, but whether these emissions are modified by arthropods has not been studied. A closed chamber system was used to measure the fluxes of carbon dioxide (CO2, methane (CH4 and nitrous oxide (N2O from dung pats with and without dung beetles on a grass sward. The presence of dung beetles significantly affected the fluxes of GHGs from dung pats. Most importantly, fresh dung pats emitted higher amounts of CO2 and lower amounts of CH4 per day in the presence than absence of beetles. Emissions of N2O showed a distinct peak three weeks after the start of the experiment--a pattern detected only in the presence of beetles. When summed over the main grazing season (June-July, total emissions of CH4 proved significantly lower, and total emissions of N2O significantly higher in the presence than absence of beetles. While clearly conditional on the experimental conditions, the patterns observed here reveal a potential impact of dung beetles on gas fluxes realized at a small spatial scale, and thereby suggest that arthropods may have an overall effect on gas fluxes from agriculture. Dissecting the exact mechanisms behind these effects, mapping out the range of conditions under which they occur, and quantifying effect sizes under variable environmental conditions emerge as key priorities for further research.

  8. Quantifying Beetle-Mediated Effects on Gas Fluxes from Dung Pats

    Science.gov (United States)

    Penttilä, Atte; Slade, Eleanor M.; Simojoki, Asko; Riutta, Terhi; Minkkinen, Kari; Roslin, Tomas

    2013-01-01

    Agriculture is one of the largest contributors of the anthropogenic greenhouse gases (GHGs) responsible for global warming. Measurements of gas fluxes from dung pats suggest that dung is a source of GHGs, but whether these emissions are modified by arthropods has not been studied. A closed chamber system was used to measure the fluxes of carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O) from dung pats with and without dung beetles on a grass sward. The presence of dung beetles significantly affected the fluxes of GHGs from dung pats. Most importantly, fresh dung pats emitted higher amounts of CO2 and lower amounts of CH4 per day in the presence than absence of beetles. Emissions of N2O showed a distinct peak three weeks after the start of the experiment – a pattern detected only in the presence of beetles. When summed over the main grazing season (June–July), total emissions of CH4 proved significantly lower, and total emissions of N2O significantly higher in the presence than absence of beetles. While clearly conditional on the experimental conditions, the patterns observed here reveal a potential impact of dung beetles on gas fluxes realized at a small spatial scale, and thereby suggest that arthropods may have an overall effect on gas fluxes from agriculture. Dissecting the exact mechanisms behind these effects, mapping out the range of conditions under which they occur, and quantifying effect sizes under variable environmental conditions emerge as key priorities for further research. PMID:23940758

  9. El sistema ubicuitina/proteasoma en la interacción planta-patógeno

    Directory of Open Access Journals (Sweden)

    Mario Rocha-Sosa

    2013-01-01

    Full Text Available La ubicuitina (Ub es una proteína pequeña la cual es utilizada por los organismos eucariontes para marcar proteínas, en la mayoría de los casos para que éstas sean posteriormente degradadas. La ubicuitinación ocurre en tres pasos sucesivos los cuales requieren de la acción de una enzima activadora, una enzima conjugadora y una ligasa de Ub. Una vez ubicuitinada la proteína seguirá un destino diferente de acuerdo a la topología de la ubicuitinación. Muchas de las proteínas marcadas por ubicuitinación serán degradadas por un complejo proteínico de 2.5 Mda conocido como el proteasoma 26S. Las plantas emplean ampliamente este mecanismo de degradación regulada de proteínas para modular procesos de crecimiento y desarrollo o bien, para responder ante situaciones adversas como puede ser una baja disponibilidad de agua o el ataque por patógenos. Durante la evolución las plantas han desarrollado diversas estrategias para defenderse ante la agresión por patógenos, sin embargo, estos organismos han logrado implementar herramientas que les permiten contrarrestar los mecanismos de defensa de las plantas, entre otras formas, los patógenos han logrado manipular el sistema Ub/proteasoma para poder infectarlas eficientemente.

  10. Utility of the pat gene as a selectable marker gene in production of transgenic Dunaliella salina

    Directory of Open Access Journals (Sweden)

    Hyo Sun Jung

    2016-09-01

    Full Text Available Abstract Background The objective of this study was to develop an efficient selectable marker for transgenic Dunaliella salina. Results Tests of the sensitivity of D. salina to the antibiotic chloramphenicol and the herbicide Basta® showed that cells (1.0 × 106 cells/ml treated with 1000 or 1500 μg/ml chloramphenicol died in 8 or 6 days, respectively, whereas D. salina cells (1.0 × 106 cells/ml treated with 5, 10, 20, or 40 μg/ml Basta® died in 2 days. Therefore, D. salina is more sensitive to Basta® than to chloramphenicol. To examine the possibility of using the phosphinothricin N-acetyltransferase (pat gene as a selectable marker gene, we introduced the pat genes into D. salina with particle bombardment system under the condition of helium pressure of 900 psi from a distance of 3 cm. PCR analysis confirmed that the gene was stably inserted into the cells and that the cells survived in 5 μg/ml Basta®, the medium used to select the transformed cells. Conclusions The findings of this study suggest that the pat gene can be used as an efficient selectable marker when producing transgenic D. salina.

  11. Transmisión de protozoarios patógenos a través del agua para consumo humano

    National Research Council Canada - National Science Library

    Yezid Solarte; Miguel Peña; Carlos Madera

    2006-01-01

    Los protozoarios patógenos Cryptosporidium parvum y Giardia sp. han demostrado su infectividad e impacto negativo en la salud de miles de personas tanto en naciones industrializadas como en los países en desarrollo...

  12. 26 April 2012 - Extraordinary and plenipotentiary Ambassador A. Dékány, Permanent Representative of the Republic of Hungary to the United Nations Office and other international organisations at Geneva, signing the guest book with CERN Director-General R. Heuer; visiting the LHC tunnel at Point 5 and CMS experimental area and surface building with Collaboration Deputy Spokespersom T. Camporesi; accompanied by M. Bajko, Technology Department. International Relations Office Adviser R. Voss also present.

    CERN Multimedia

    Jean-claude Gadmer

    2012-01-01

    26 April 2012 - Extraordinary and plenipotentiary Ambassador A. Dékány, Permanent Representative of the Republic of Hungary to the United Nations Office and other international organisations at Geneva, signing the guest book with CERN Director-General R. Heuer; visiting the LHC tunnel at Point 5 and CMS experimental area and surface building with Collaboration Deputy Spokespersom T. Camporesi; accompanied by M. Bajko, Technology Department. International Relations Office Adviser R. Voss also present.

  13. 29 October 2013 - Former Director-General of IAEA H. Blix on the occasion of the Thorium Energy Conference at CERN with Chair of the ThEC13 Organization Committee E. Lillestol and Author of the book “Atome Vert” (Green Atom) J.-C. de Mestral; in the LHC tunnel at Point 1 with Technology Department, Machine Protection & Electrical Integrity Group, Performance Evaluation Section Member A. Verweij.

    CERN Multimedia

    Anna Pantelia

    2013-01-01

    29 October 2013 - Former Director-General of IAEA H. Blix on the occasion of the Thorium Energy Conference at CERN with Chair of the ThEC13 Organization Committee E. Lillestol and Author of the book “Atome Vert” (Green Atom) J.-C. de Mestral; in the LHC tunnel at Point 1 with Technology Department, Machine Protection & Electrical Integrity Group, Performance Evaluation Section Member A. Verweij.

  14. 10 October 2013 - D. Braun First Deputy Minister for Regional Development, Czech Republic, P. Styczeń Deputy Minister of Transport, Construction and Maritime Economy, Republic of Poland and F. Palko State Secretary, Ministry of Transport, Construction and Regional Development, Slovak Republic visiting the LHC tunnel at Point 1 with Technology Department, Vacuum, Surfaces and Coatings Group Leader J. M. Jimenez and signing the Guest book with CERN Director-General R. Heuer

    CERN Multimedia

    Anna Pantelia

    2013-01-01

    10 October 2013 - D. Braun First Deputy Minister for Regional Development, Czech Republic, P. Styczeń Deputy Minister of Transport, Construction and Maritime Economy, Republic of Poland and F. Palko State Secretary, Ministry of Transport, Construction and Regional Development, Slovak Republic visiting the LHC tunnel at Point 1 with Technology Department, Vacuum, Surfaces and Coatings Group Leader J. M. Jimenez and signing the Guest book with CERN Director-General R. Heuer

  15. A Robust Process Analytical Technology (PAT) System Design for Crystallization Processes

    DEFF Research Database (Denmark)

    Abdul Samad, Noor Asma Fazli Bin; Sin, Gürkan; Gernaey, Krist

    2013-01-01

    A generic computer-aided framework for systematic design of a process monitoring and control system for crystallization processes has been developed to study various aspects of crystallization operations. The design framework contains a generic multidimensional modelling framework, a tool for gen...

  16. The Lsm1-7-Pat1 complex promotes viral RNA translation and replication by differential mechanisms.

    Science.gov (United States)

    Jungfleisch, Jennifer; Chowdhury, Ashis; Alves-Rodrigues, Isabel; Tharun, Sundaresan; Díez, Juana

    2015-08-01

    The Lsm1-7-Pat1 complex binds to the 3' end of cellular mRNAs and promotes 3' end protection and 5'-3' decay. Interestingly, this complex also specifically binds to cis-acting regulatory sequences of viral positive-strand RNA genomes promoting their translation and subsequent recruitment from translation to replication. Yet, how the Lsm1-7-Pat1 complex regulates these two processes remains elusive. Here, we show that Lsm1-7-Pat1 complex acts differentially in these processes. By using a collection of well-characterized lsm1 mutant alleles and a system that allows the replication of Brome mosaic virus (BMV) in yeast we show that the Lsm1-7-Pat1 complex integrity is essential for both, translation and recruitment. However, the intrinsic RNA-binding ability of the complex is only required for translation. Consistent with an RNA-binding-independent function of the Lsm1-7-Pat1 complex on BMV RNA recruitment, we show that the BMV 1a protein, the sole viral protein required for recruitment, interacts with this complex in an RNA-independent manner. Together, these results support a model wherein Lsm1-7-Pat1 complex binds consecutively to BMV RNA regulatory sequences and the 1a protein to promote viral RNA translation and later recruitment out of the host translation machinery to the viral replication complexes.

  17. The Curriculum Director: Power vs. Persuasion.

    Science.gov (United States)

    Reader, William; Taylor, Bob L.

    A study was done at the University of Colorado to determine the qualifications, priorities, behaviors, and authority base of effective curriculum directors in six Colorado school districts. The study employed both qualitative and quantitative research. The qualitative data were obtained by observing and interviewing the curriculum directors and by…

  18. 12 CFR 619.9235 - Outside director.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Outside director. 619.9235 Section 619.9235 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM DEFINITIONS § 619.9235 Outside director..., employee, agent, or stockholder of any Farm Credit System institution....

  19. Beyond Field Education: Leadership of Field Directors

    Science.gov (United States)

    Wertheimer, Mindy R.; Sodhi, Mimi

    2014-01-01

    This article presents a conceptual model of the field director's role outside of field education, specifically in the following 3 areas of leadership: (1) curricular, (2) programmatic, and (3) institutional. A survey was conducted to explore the field director's input targeted in these areas beyond prescribed field education tasks. The…

  20. Robert Aymar, Director-General of CERN

    CERN Multimedia

    Patrice Loïez

    2003-01-01

    Robert Aymar, photographed in 2003 before taking his position as Director-General at CERN, succeeding Luciano Maiani in 2004. At this time, Aymar was director of the International Thermonuclear Experimental Reactor (ITER) although he had already been involved with developments at CERN, chairing the External Review Committee, set up in 2001 in response to the increased cost of the LHC.

  1. 75 FR 64641 - Facilitating Shareholder Director Nominations

    Science.gov (United States)

    2010-10-20

    ... state law rights to nominate and elect directors to company boards of directors. We are publishing this... effective date of November 15, 2010, and a compliance date of November 15, 2010, except that companies that... compliance dates. SUMMARY: By order dated October 4, 2010 (Release No. 33-9149, 34- 63031), the Securities...

  2. J. B. Adams Acting Director-General

    CERN Multimedia

    1960-01-01

    After the tragic death of Prof. C. J. Bakker, the Council of CERN held an emergency meeting on May 3, 1960. Following this session, Mr. F. de Rose, President of the Council of the European Organization for Nuclear Research, announced the appointment of Mr. J. B. Adams, Director of the PS division to the post of acting Director-General.

  3. Predictors of Choral Directors' Voice Handicap

    Science.gov (United States)

    Schwartz, Sandra

    2013-01-01

    Vocal demands of teaching are considerable and these challenges are greater for choral directors who depend on the voice as a musical and instructive instrument. The purpose of this study was to (1) examine choral directors' vocal condition using a modified Voice Handicap Index (VHI), and (2) determine the extent to which the major variables…

  4. CERN loses two former Directors-General

    CERN Document Server

    2002-01-01

    Victor Weisskopf, a giant of modern physics and Director General of CERN from 1961-65, died on 21 April. The previous month, Willibald Jentschke, Director General from 1971-75 and founder of the DESY Laboratory in Hamburg, passed away.

  5. Reference 2001: A Director's Admonitions.

    Science.gov (United States)

    Seal, Robert A.

    2001-01-01

    Reflects on the professional roles and responsibilities as well as opportunities and challenges facing academic reference librarians in light of new technology. Discusses services to undergraduates, graduate students, and faculty; empowering users; library instruction; information literacy; information technology; electronic information; building…

  6. Improving drug manufacturing with process analytical technology.

    Science.gov (United States)

    Rodrigues, Licinia O; Alves, Teresa P; Cardoso, Joaquim P; Menezes, José C

    2006-01-01

    Within the process analytical technology (PAT) framework, as presented in the US Food and Drug Administration guidelines, the aim is to design, develop and operate processes consistently to ensure a pre-defined level of quality at the end of the manufacturing process. Three PAT implementation scenarios can be envisaged. Firstly, PAT could be used in its most modest version (in an almost non-PAT manner) to simply replace an existing quality control protocol (eg, using near-infrared spectroscopy for an in-process quality control, such as moisture content). Secondly, the use of in-process monitoring and process analysis could be integrated to enhance process understanding and operation for an existing industrial process. Thirdly, PAT could be used extensively and exclusively throughout development, scale-up and full-scale production of a new product and process. Although the first type of implementations are well known, reports of the second and third types remain scarce. Herein, results obtained from PAT implementations of the second and third types are described for two industrial processes for preparing bulk active pharmaceutical ingredients, demonstrating the benefits in terms of increased process understanding and process control.

  7. Transcriptomic analysis of tomato carpel development reveals alterations in ethylene and gibberellin synthesis during pat3/pat4 parthenocarpic fruit set

    Directory of Open Access Journals (Sweden)

    Pascual Laura

    2009-05-01

    Full Text Available Abstract Background Tomato fruit set is a key process that has a great economic impact on crop production. We employed the Affymetrix GeneChip Tomato Genome Array to compare the transcriptome of a non-parthenocarpic line, UC82, with that of the parthenocarpic line RP75/59 (pat3/pat4 mutant. We analyzed the transcriptome under normal conditions as well as with forced parthenocarpic development in RP75/59, emasculating the flowers 2 days before anthesis. This analysis helps to understand the fruit set in tomato. Results Differentially expressed genes were extracted with maSigPro, which is designed for the analysis of single and multiseries time course microarray experiments. 2842 genes showed changes throughout normal carpel development and fruit set. Most of them showed a change of expression at or after anthesis. The main differences between lines were concentrated at the anthesis stage. We found 758 genes differentially expressed in parthenocarpic fruit set. Among these genes we detected cell cycle-related genes that were still activated at anthesis in the parthenocarpic line, which shows the lack of arrest in the parthenocarpic line at anthesis. Key genes for the synthesis of gibberellins and ethylene, which were up-regulated in the parthenocarpic line were also detected. Conclusion Comparisons between array experiments determined that anthesis was the most different stage and the key point at which most of the genes were modulated. In the parthenocarpic line, anthesis seemed to be a short transitional stage to fruit set. In this line, the high GAs contends leads to the development of a parthenocarpic fruit, and ethylene may mimic pollination signals, inducing auxin synthesis in the ovary and the development of a jelly fruit.

  8. Computer Science Research: Computation Directorate

    Energy Technology Data Exchange (ETDEWEB)

    Durst, M.J. (ed.); Grupe, K.F. (ed.)

    1988-01-01

    This report contains short papers in the following areas: large-scale scientific computation; parallel computing; general-purpose numerical algorithms; distributed operating systems and networks; knowledge-based systems; and technology information systems.

  9. Catherine Cesarsky - ESO's Next Director General

    Science.gov (United States)

    1999-01-01

    The ESO Council has appointed Dr. Catherine Cesarsky as Director General for a five year period, succeeding Professor Riccardo Giacconi, whose term ends this year. Dr. Cesarsky will take up her duties on September 1, 1999, at the ESO Headquarters in Garching (Germany). Dr. Cesarsky was born in France in 1943. She received a degree in Physical Sciences at the University of Buenos Aires and graduated with a PhD in Astronomy in 1971 from Harvard University (Cambridge, Mass., USA). Afterwards she worked at the California Institute of Technology (CALTECH). In 1974, she became a staff member of the Service d'Astrophysique (SAp) , Direction des Sciences de la Matière (DSM), Commissariat à l'Energie Atomique (CEA) (France). She headed the theoretical group of the SAp (1978-1985), was Head of SAp (1985-1993) and has been Director of DSM since 1994. The DSM encompasses, at the CEA, activities of basic research in physics, chemistry, astrophysics and earth sciences and comprises about 3000 scientists, engineers, technicians, etc. Dr. Cesarsky is known for her successful research activities in several central areas of modern astrophysics. The first part of her career was devoted to the high-energy domain. This has involved studies of the propagation and composition of galactic cosmic rays, of matter and fields in the diffuse interstellar medium, as well as the acceleration of particles in astrophysical shocks, e.g. in connection with supernovae. She then turned to infrared astronomy. She is the Principal Investigator of the ISOCAM camera onboard the Infrared Space Observatory (ISO) of the European Space Agency (ESA) and, as such, she leads the ISOCAM central programme. It studies, in a coordinated way, the infrared emission from a variety of galactic and extragalactic sources and is yielding new and exciting results on star formation and galactic evolution. Dr. Cesarsky received the COSPAR (Committee on Space Research) Space Science Award in 1998. She is a member of many

  10. Petrology and Geochemistry of LEW 88663 and PAT 91501: High Petrologic L Chondrites

    Science.gov (United States)

    Mittlefehldt, D. W.; Lindstrom, M. M.; Field, S. W.

    1993-07-01

    Primitive achondrites (e.g., Acapulco, Lodran) are believed to be highly metamorphosed chondritic materials, perhaps up to the point of anatexis in some types. Low petrologic grade equivalents of these achondrites are unknown, so the petrologic transition from chondritic to achondritic material cannot be documented. However, there are rare L chondrites of petrologic grade 7 that may have experienced igneous processes, and study of these may yield information relevant to the formation of primitive achondrites, and perhaps basaltic achondrites, from chondritic precursors. We have begun the study of the L7 chondrites LEW 88663 and PAT 91501 as part of our broader study of primitive achondrites. Here, we present our preliminary petrologic and geochemical data on these meteorites. Petrology and Mineral Compositions: LEW 88663 is a granular achondrite composed of equant, subhedral to anhedral olivine grains poikilitically enclosed in networks of orthopyroxene and plagioclase. Small grains of clinopyroxene are spatially associated with orthopyroxene. Troilite occurs as large anhedral and small rounded grains. The smaller troilite grains are associated with the orthopyroxene-plagioclase networks. PAT 91501 is a vesicular stone containing centimeter-sized troilite +/- metal nodules. Its texture consists of anhedral to euhedral olivine grains, anhedral orthopyroxene grains (some with euhedral clinopyroxene overgrowths), anhedral to euhedral clinopyroxene, and interstitial plagioclase and SiO2-Al2O3-K2O- rich glass. In some areas, olivine is poikilitically enclosed in orthopyroxene. Fine-grained troilite, metal, and euhedral chromite occur interstitial to the silicates. Average mineral compositions for LEW 88663 are olivine Fo(sub)75.8, orthopyroxene Wo(sub)3.4En(sub)76.2Fs(sub)20.4, clinopyroxene Wo(sub)42.6En(sub)47.8Fs(sub)9.6, plagioclase Ab(sub)75.0An(sub)21.6Or(sub)3.4. Mineral compositions for PAT 91501 are olivine Fo(sub)73.8, orthopyroxene Wo(sub)4.5En(sub)74.8Fs

  11. Emergency Medicine Clerkship Directors: Current Workforce

    Directory of Open Access Journals (Sweden)

    David A. Wald

    2014-07-01

    Full Text Available Introduction: The emergency medicine clerkship director serves an important role in the education of medical students. The authors sought to update the demographic and academic profile of the emergency medicine clerkship director. Methods: We developed and implemented a comprehensive questionnaire, and used it to survey all emergency medicine clerkship directors at United States allopathic medical schools accredited by the Liaison Committee on Medical Education. We analyzed and interpreted data using descriptive statistics. Results: One hundred seven of 133 (80.4% emergency medicine clerkship directors completed the survey. Clerkship Director’s mean age was 39.7 years (SD-7.2, they were more commonly male 68.2%, of Caucasian racial backgrounds and at the instructor or assistant professor (71.3% level. The mean number of years of experience as clerkship director was 5.5 (SD-4.5. The mean amount of protected time for clerkship administration reported by respondents was 7.3 hours weekly (SD-5.1, with the majority (53.8% reporting 6 or more hours of protected time per week. However, 32.7% of emergency medicine clerkship directors reported not having any protected time for clerkship administration. Most clerkship directors (91.6% held additional teaching responsibilities beyond their clerkship and many were involved in educational research (49.5%. The majority (79.8%, reported being somewhat or very satisfied with their job as clerkship director. Conclusion: Most clerkship directors were junior faculty at the instructor or assistant professor rank and were involved with a variety of educational endeavors beyond the clerkship. [West J Emerg Med. 2014;15(4:398–403.

  12. 29 March 2011 - Ninth President of Israel S.Peres welcomed by CERN Director-General R. Heuer who introduces Council President M. Spiro, Director for Accelerators and Technology S. Myers, Head of International Relations F. Pauss, Physics Department Head P. Bloch, Technology Department Head F. Bordry, Human Resources Department Head A.-S. Catherin, Beams Department Head P. Collier, Information Technology Department Head F. Hemmer, Adviser for Israel J. Ellis, Legal Counsel E. Gröniger-Voss, ATLAS Collaboration Spokesperson F. Gianotti, Former ATLAS Collaboration Spokesperson P. Jenni, Weizmann Institute G. Mikenberg, CERN VIP and Protocol Officer W. Korda.

    CERN Document Server

    Maximilien Brice

    2011-01-01

    During his visit he toured the ATLAS underground experimental area with Giora Mikenberg of the ATLAS collaboration, Weizmann Institute of Sciences and Israeli industrial liaison office, Rolf Heuer, CERN’s director-general, and Fabiola Gianotti, ATLAS spokesperson. The president also visited the CERN computing centre and met Israeli scientists working at CERN.

  13. What every library director should know

    CERN Document Server

    Curzon, Susan Carol

    2014-01-01

    What Every Library Director Should Know is the insider's view of vital actions, behaviors and strategies to succeed in every type of library. The content is based both on the author's direct experience after a long career in several types of libraries but also on the direct observation of other managers. Inset into the book are pearls of wisdom from other directors, managers and observers who are answering the question, "what is the one piece of management wisdom that you would give to anyone who wishes to become a library director?" This book will help to get you there by explaining and illus

  14. Gender Quotas on Board of Directors

    DEFF Research Database (Denmark)

    Smith, Nina

    2013-01-01

    on the grounds of economic efficiency. Furthermore, in most countries a limited number of women are qualified to join boards of directors, and it is not clear from the evidence to date on the operation of quotas whether they will lead to a better pool of female candidates in the medium and long term.......Beside arguments of fairness and equal opportunities, it is often argued that gender diversity on boards of directors may improve firm performance, but the empirical results are mixed and often negative. Based on the available research, gender quotas on boards of directors cannot be justified...

  15. 32 CFR 2400.19 - Declassification by the Director of the Information Security Oversight Office.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Declassification by the Director of the Information Security Oversight Office. 2400.19 Section 2400.19 National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY...

  16. 2 February 2010-Bristol University Vice-Chancellor E. Thomas visiting SM18 hall with Beams Department Head P. Collier and Technology Department Senior Engineer R. Veness; signing the guest book with CERN Director-General R. Heuer.

    CERN Multimedia

    Maximilien Brice

    2010-01-01

    Caption for photograph 1239013 from left to right: University of Bristol and CMS Collaboration D. Newbold; University of Bristol Team Leader and LHCb Collaboration N. Brook; Bristol University Pro-Vice-Chancellor for Research G. Orpen; Beams Department Head P. Collier; Bristol University Vice-Chancellor E. Thomas;Technology Department Senior Engineer R. Veness in the SM18 hall.

  17. Intestinal drug transport via the proton-coupled amino acid transporter PAT1 (SLC36A1) is inhibited by Gly-X(aa) dipeptides

    DEFF Research Database (Denmark)

    Frølund, Sidsel; Langthaler, Louise; Kall, Morten A

    2012-01-01

    The oral absorption of some drug substances is mediated by nutrient transporters. As a consequence, nutrients and drugs may compete for available transporters, and interactions at the level of intestinal absorption are possible. Recently, we have identified δ-aminolevulinic acid, Gly-Gly, and Gly......-Sar as substrates of the amino acid transporter PAT1. The aim of the present study is to investigate if other Gly-containing dipeptides interact with PAT1, and whether they can inhibit PAT1 mediated drug absorption, in vitro and in vivo. The in vitro methods included two-electrode voltage clamp measurements on h......PAT1 expressing Xenopus laevis oocytes, which were used to investigate the PAT1-mediated transport of 17 different Gly-containing dipeptides (Gly-X(aa) or X(aa)-Gly). Also, the transepithelial transport of the PAT1 substrate gaboxadol was investigated across Caco-2 cell monolayers in the presence...

  18. On the avifauna of the upper patía valley, southwestern colombia

    OpenAIRE

    Haffer, Jürgen

    2012-01-01

    The bird fauna of the isolated arid Andean valley of the upper río Patia, southwestern Colombia, resembles that of the Cauca Valley to the north.  The most prominent faunal element are widely distributed nonforest birds of the Tropical Zone which entered the Andean valleys of Colombia from the Caribbean lowlands to the north. The relations between the upper Patía fauna and the nonforest fauna of western Ecuador to the south are very restricted (e.g. Veniliornis callonotus). Montane species of...

  19. Estudio de la prevalencia de diferentes patógenos respiratorios: aportaciones microbiológicas

    OpenAIRE

    Calvo Zamorano, Almudena

    2011-01-01

    El incremento de la resistencia en los patógenos respiratorios causantes de infecciones respiratorias en la comunidad, como su variabilidad geográfica y anual, empujan a la necesidad de realizar continuos estudios de sensibilidad. La distribución por áreas puede presentar diferencias significativas achacables a muchos factores, por este motivo dependiendo de cada región se deberían tener datos propios y actualizados periódicamente. Además, el aumento de las cifras de aislados S. pneumon...

  20. Phytoplankton diversity of two floodplain lakes (pats) of Manipur, northeastern India

    OpenAIRE

    Sharma, B. K.

    2010-01-01

    Phytoplankton communities of Utra and Waithou pats (floodplain lakes) of Manipur, studied during November 2002 - October 2004, revealed 62 and 61 species, and indicated monthly richness between 27-45 (38 � plus or minus 4) and 32-46 (39 � plus or minus 4) species respectively with distinct qualitative importance of Chlorophyta (29 � plus or minus 4 and 28 � plus or minus 3 species). Phytoplankton (154 � plus or minus 31 n/l and 164 � plus or minus 34 n/l) comprised between 43.8 � plus or min...

  1. Ecología de los hongos patógenos para el hombre

    OpenAIRE

    Rubén López Martínez

    2005-01-01

    Uno de los procesos evolutivos de mayor importancia en los hongos es la adaptabilidad que algunos de ellos han desarrollado para vivir, no solamente sobre la materia orgánica inerte, sino también en organismos vivos como plantas, animales y el hombre, causándoles algún daño. Este trance evolutivo les dio la categoría de parásitos, que pueden ser temporales, facultativos o permanentes. De acuerdo al hábitat de estos hongos patógenos para el hombre, pueden ser antropofílicos, zoofílicos y geofí...

  2. The Killer Will Remain Free: On Pat Parker and the Poetics of Madness.

    Science.gov (United States)

    Ali, Kazim

    2015-01-01

    Poet and scholar Kazim Ali reads Pat Parker's Movement in Black intimately, one poet to another, uncovering the shadow-fact of the lives of most people of color: not only the anger that is somehow sublimated into every part of our lives but also the issue that carrying this feeling around has on our mental health itself-that "anger" and "madness" might have sources in one another. Ali concludes that Parker offers a brutal and clear-eyed and ultimately hopeful assessment of the conditions that were faced at the time, and even now, by communities of color.

  3. Actinobacillus Actinomycetemcomitans y Porphyromonas Gingivales como principales patógenos periodontales

    Directory of Open Access Journals (Sweden)

    A Bascones

    2000-09-01

    Full Text Available Entre las bacterias relacionadas con la enfermedad periodontal, existen dos especies más claramente asociadas a esta enfermedad: Actinobacillus actinomycetemcomitans y Porphyromonas gingivalis. Este trabajo es una revisión bibliográfica sobre estos dos patógenos periodontales, mostrando su origen, prevalencia, distribución, transmisión y respuesta al tratamiento periodontal.Among the bacteria related to periodontal disease, there are two species clearly associated to this disease: Actinobacillus actinomycetemcomitans and Porphyromonas gingiva lis. This paper presents a review of the literature regarding this two periodontal pathogens, and showing their origin, prevalence, distribution, transmission and response to periodontal treatment.

  4. Cobre antimicrobiano contra patógenos intrahospitalarios en Perú

    Directory of Open Access Journals (Sweden)

    Edwin Neciosup

    2015-01-01

    Full Text Available Introducción: Las infecciones intrahospitalarias (IIH constituyen un problema de salud pública que generan grandes gastos por parte de los gobiernos, debido a que los patógenos causantes de IIH presentan resistencia a fármacos y generan una mayor permanencia de los pacientes, pues la infraestructura hospitalaria constituye un reservorio favorable para los patógenos. Las superficies de cobre surgen como opción sanitaria y efectiva para controlar el crecimiento y propagación de estos patógenos. Objetivos: Evaluar la actividad bactericida de las superficies de cobre contra los principales bacterias patógenas causantes de IIH (Escherichia coli, Pseudomonas aeruginosa y Staphylococcus aureus. Diseño: Estudio experimental con muestreo no probabilístico. Lugar: Hospital Regional Docente las Mercedes (HRDLM y Hospital Provincial Docente Belén (HPDB, Lambayeque, Perú. Materiales: Nueve cepas bacterianas, 3 de E. coli , 3 de P. aeruginosa y 3 de S. aureus; superficies metálicas (1 cm² de cobre y acero inoxidable (control . Intervenciones: Las 9 cepas bacterianas fueron proporcionadas por los hospitales HRDLM (4 cepas y HPDB (5 cepas. Los análisis de ANOVA y de Tukey fueron aplicados para evaluar la actividad bactericida de las superficies de cobre y acero inoxidable contra las 9 cepas causantes de IIH, usando los programas estadísticos Minitab y Sigmaplot, respectivamente. Principales medidas de resultados: Diferencias en el crecimiento bacteriano sobre superficies de cobre o acero inoxidable, con respecto al tiempo de exposición. Resultados: Las 9 cepas -3 de P. aeruginosa, 3 de E. coli y 3 de S. aureus - expuestas a superficies de cobre fueron eliminadas en 10, 15 y 60 minutos, respectivamente. La carga bacteriana de las células expuestas en superficies de acero inoxidable permaneció constante y viable por periodos mayores a 60 minutos. Además, las superficies de cobre eliminaron más rápido a las bacterias Gram negativas (P

  5. Wanted: Fermilab director who can build consensus

    CERN Multimedia

    Pierce, G M

    2004-01-01

    "With current Fermilab Director Michael Witherell stepping down in July 2005, an appointed committee has vowed to find a new leader who will keep the Batavia lab at the forefront of the high-energy physics field" (1 page).

  6. 40 CFR 792.33 - Study director.

    Science.gov (United States)

    2010-07-01

    ...) GOOD LABORATORY PRACTICE STANDARDS Organization and Personnel § 792.33 Study director. For each study, a scientist or other professional of appropriate education, training, and experience, or combination...

  7. From The NIH Director - Envisioning the Future

    Science.gov (United States)

    ... Navigation Bar Home Current Issue Past Issues From The NIH Director Envisioning the Future Past Issues / Winter 2008 Table of Contents ... was that, in fact, you could look inside the human body without destroying it." Dr. Zerhouni : My ...

  8. Compendium of Directors Colloquia 1999-2012

    Science.gov (United States)

    Langhoff, Stephanie

    2013-01-01

    The Director s colloquium series was established primarily to provide a mechanism to bring high profile individuals to the Center to present new and innovative ideas to the entire Ames staff. More focused lecture series are arranged by specific divisions or departments. Before the year 1999, there is only a fragmentary record of who spoke in this series. Announcements to the staff were sent via land mail, and tickets were required to attend the colloquium. In 1999, the notification to attend colloquia became electronic and the entire resident staff was invited to attend. The centerwide announcement archive established in this timeframe created a lasting record of the Director s colloquia. The "Office of the Chief Scientist" at Ames had the responsibility for administering the colloquium series. When I became Chief Scientist on June 29, 1998, the program was not being used extensively and this continued to be the case through the years 1999-2002 of Harry McDonald s tenure as Director (see graph below). During Scott Hubbard s tenure as Director (September 19, 2002- February 15, 2006), the Director's colloquium series was used exclusively for high profile speakers from outside Ames whom he selected, such as lab directors from other research organizations around the Bay Area. During Pete Worden s tenure as Ames Director (May 4, 2006 -present) the colloquium series gained far greater use. First, I had greater discretion to select speakers for the colloquium series. Secondly, beginning in 2007, we established a 10-week Director's Colloquium Summer Series focused on enriching the experience of our many summer interns, and giving our top researchers within Ames Research Center an opportunity to present their work to the Center. The summer program has received rave reviews. This compendium contains a compilation of one-page descriptions (title, abstract and speaker biographies) for all of the 171 colloquia presented from the beginning of 1999 to October of 2012. The list of

  9. VMware vCloud director cookbook

    CERN Document Server

    Langenhan, Daniel

    2013-01-01

    VMware vCloud Director Cookbook will adopt a Cookbook-based approach. Packed with illustrations and programming examples, this book explains the simple as well as the complex recipes in an easy-to-understand language.""VMware vCloud Director Cookbook"" is aimed at system administrators and technical architects moving from a virtualized environment to cloud environments. Familiarity with cloud computing platforms and some knowledge of virtualization and managing cloud environments is expected.

  10. HetF and PatA control levels of HetR in Anabaena sp. strain PCC 7120.

    Science.gov (United States)

    Risser, Douglas D; Callahan, Sean M

    2008-12-01

    Anabaena sp. strain PCC 7120 is a filamentous cyanobacterium that differentiates heterocysts in response to deprivation of combined nitrogen. A hetF deletion strain lacked heterocysts and had aberrant cell morphology. Site-directed mutagenesis of the predicted active-site histidine and cysteine residues of this putative caspase-hemoglobinase fold protease abolished HetF function, supporting the hypothesis that HetF is a protease. Deletion of patA, which is necessary for the formation of most intercalary heterocysts, or hetF resulted in an increase in HetR protein, and extra copies of hetF on a plasmid functionally bypassed the deletion of patA. A hetR-gfp translational fusion expressed from an inducible promoter demonstrated that hetF-dependent downregulation of HetR levels occurs rapidly in vegetative cells, as well as developing heterocysts. "Mosaic" filaments in which only one cell of a filament had a copy of hetR or hetF indicated that hetF is required for differentiation only in cells that will become heterocysts. hetF was required for transcription from a hetR-dependent transcription start point of the hetR promoter and induction of transcription from the patS promoter. The inverse correlation between the level of HetR protein and transcription from hetR-dependent promoters suggests that the transcriptional activity of HetR is regulated by HetF and PatA.

  11. The structure of the cyanobactin domain of unknown function from PatG in the patellamide gene cluster.

    Science.gov (United States)

    Mann, Greg; Koehnke, Jesko; Bent, Andrew F; Graham, Rachael; Houssen, Wael; Jaspars, Marcel; Schwarz-Linek, Uli; Naismith, James H

    2014-12-01

    Patellamides are members of the cyanobactin family of ribosomally synthesized and post-translationally modified cyclic peptide natural products, many of which, including some patellamides, are biologically active. A detailed mechanistic understanding of the biosynthetic pathway would enable the construction of a biotechnological `toolkit' to make novel analogues of patellamides that are not found in nature. All but two of the protein domains involved in patellamide biosynthesis have been characterized. The two domains of unknown function (DUFs) are homologous to each other and are found at the C-termini of the multi-domain proteins PatA and PatG. The domain sequence is found in all cyanobactin-biosynthetic pathways characterized to date, implying a functional role in cyanobactin biosynthesis. Here, the crystal structure of the PatG DUF domain is reported and its binding interactions with plausible substrates are investigated.

  12. The structure of the cyanobactin domain of unknown function from PatG in the patellamide gene cluster

    Science.gov (United States)

    Mann, Greg; Koehnke, Jesko; Bent, Andrew F.; Graham, Rachael; Houssen, Wael; Jaspars, Marcel; Schwarz-Linek, Uli; Naismith, James H.

    2014-01-01

    Patellamides are members of the cyanobactin family of ribosomally synthesized and post-translationally modified cyclic peptide natural products, many of which, including some patellamides, are biologically active. A detailed mechanistic understanding of the biosynthetic pathway would enable the construction of a biotechnological ‘toolkit’ to make novel analogues of patellamides that are not found in nature. All but two of the protein domains involved in patellamide biosynthesis have been characterized. The two domains of unknown function (DUFs) are homologous to each other and are found at the C-termini of the multi-domain proteins PatA and PatG. The domain sequence is found in all cyanobactin-biosynthetic pathways characterized to date, implying a functional role in cyanobactin biosynthesis. Here, the crystal structure of the PatG DUF domain is reported and its binding interactions with plausible substrates are investigated. PMID:25484206

  13. The anti-cancer IgM monoclonal antibody PAT-SM6 binds with high avidity to the unfolded protein response regulator GRP78.

    Directory of Open Access Journals (Sweden)

    Zachary Rosenes

    Full Text Available The monoclonal IgM antibody PAT-SM6 derived from human tumours induces apoptosis in tumour cells and is considered a potential anti-cancer agent. A primary target for PAT-SM6 is the unfolded protein response regulator GRP78, over-expressed externally on the cell surface of tumour cells. Small angle X-ray scattering (SAXS studies of human GRP78 showed a two-domain dumbbell-shaped monomer, while SAXS analysis of PAT-SM6 revealed a saucer-shaped structure accommodating five-fold symmetry, consistent with previous studies of related proteins. Sedimentation velocity analysis of GRP78 and PAT-SM6 mixtures indicated weak complex formation characterized by dissociation constants in the high micromolar concentration range. In contrast, enzyme-linked immunosorbant assays (ELISAs showed strong and specific interactions between PAT-SM6 and immobilized GRP78. The apparent binding constant estimated from a PAT-SM6 saturation curve correlated strongly with the concentration of GRP78 used to coat the microtiter tray. Experiments using polyclonal antiGRP78 IgG antibodies or a monoclonal IgG derivative of PAT-SM6 did not show a similar dependence. Competition experiments with soluble GRP78 indicated more effective inhibition of PAT-SM6 binding at low GRP78 coating concentrations. These observations suggest an avidity-based binding mechanism that depends on the multi-point attachment of PAT-SM6 to GRP78 clustered on the surface of the tray. Analysis of ELISA data at high GRP78 coating concentrations yielded an apparent dissociation constant of approximately 4 nM. We propose that the biological action of PAT-SM6 in tumour cell apoptosis may depend on the multivalent nature of PAT-SM6 and the high avidity of its interaction with multiple GRP78 molecules clustered on the tumour cell surface.

  14. [Impact of the Water for All Program (PAT) on childhood morbidity and mortality from diarrhea in the Bahia State, Brazil].

    Science.gov (United States)

    Rasella, Davide

    2013-01-01

    This study aimed to evaluate the impact of the Water for All Program (PAT), launched in Bahia State, Brazil, with the objective of expanding coverage of the water supply and sanitation in areas with high vulnerability to waterborne diseases. A total of 224 municipalities (counties) with adequate vital statistics were selected. A controlled before-and-after study design was used, performing analyses with multivariate negative binomial regression with fixed effects, from 2005 to 2008. PAT coverage - as a continuous variable - was negatively associated (p diarrhea, under-five mortality of 14% (p diarrhea of 6% (p water and sanitation programs can have an important impact in reducing health inequalities in the population.

  15. School directors and management in education

    Directory of Open Access Journals (Sweden)

    Srdić Vesna M.

    2015-01-01

    Full Text Available The main features of school management and organization comprise planning, decision making, management, leadership and communication. Research suggests that successful school management requires not only advanced managerial but also leadership skills, with highly developed social skills as the main competence. In a complex social system, good leadership becomes a fundamental component of a successful organization or institution. Although leadership has for a long time been of interest for theoreticians and practitioners alike, there are still numerous questions waiting to be answered in the area of management and leadership in education. According to the Law on the Basis of Educational System, the person who can be named a school director must posses appropriate education, competences, license and experience in education. Legal requirements allow the provision of effective training, but the fact that personal disposition can be both an advantage and an obstacle for acquiring necessary items of knowledge and skills, points to the necessity of including selection into the standard procedure for the election of a director. Democratization and decentralization of the educational system presupposes a series of structural, systemic and functional changes which reflect on school management and the role played by the director. This paper considers responsibilities and competences of directors, both in legislation and in school practice and addresses the question whether a school director is a manager or a leader, and what are the possibilities for the provision of professional resources for school management.

  16. 12 CFR 918.2 - Annual directors' compensation policy.

    Science.gov (United States)

    2010-01-01

    ... of their duties as members of the Bank's board of directors, subject to the requirements set forth in... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Annual directors' compensation policy. 918.2... HOME LOAN BANKS BANK DIRECTOR COMPENSATION AND EXPENSES § 918.2 Annual directors' compensation...

  17. 16 CFR 1000.26 - Directorate for Epidemiology.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Directorate for Epidemiology. 1000.26... AND FUNCTIONS § 1000.26 Directorate for Epidemiology. The Directorate for Epidemiology, managed by the Associate Executive Director for Epidemiology, is responsible for the collection and analysis of data...

  18. 12 CFR 611.1218 - Role of directors.

    Science.gov (United States)

    2010-01-01

    ... Institution Status § 611.1218 Role of directors. (a) Statements by directors. Directors may not be prohibited... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Role of directors. 611.1218 Section 611.1218... have the right to obtain independent legal and financial advice regarding the proposed termination...

  19. 16 CFR 1000.27 - Directorate for Health Sciences.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Directorate for Health Sciences. 1000.27... AND FUNCTIONS § 1000.27 Directorate for Health Sciences. The Directorate for Health Sciences is managed by the Associate Executive Director for Health Sciences and is responsible for reviewing...

  20. 12 CFR 1710.12 - Committees of board of directors.

    Science.gov (United States)

    2010-01-01

    ... board of directors of an Enterprise shall meet with sufficient frequency to carry out its obligations... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Committees of board of directors. 1710.12... § 1710.12 Committees of board of directors. (a) General. The board of directors may rely, in...

  1. 75 FR 22553 - Technology Innovation Program Advisory Board

    Science.gov (United States)

    2010-04-29

    ... National Institute of Standards and Technology Technology Innovation Program Advisory Board AGENCY.... SUMMARY: The Technology Innovation Program Advisory Board, National Institute of Standards and Technology... Technology Innovation Program (TIP) Advisory Board is composed of ten members appointed by the Director...

  2. The medical director and quality requirements in the dialysis facility.

    Science.gov (United States)

    Schiller, Brigitte

    2015-03-06

    Four decades after the successful implementation of the ESRD program currently providing life-saving dialysis therapy to >430,000 patients, the definitions of and demands for a high-quality program have evolved and increased at the same time. Through substantial technological advances ESRD care improved, with a predominant focus on the technical aspects of care and the introduction of medications such as erythropoiesis-stimulating agents and active vitamin D for anemia and bone disease management. Despite many advances, the size of the program and the increasingly older and multimorbid patient population have contributed to continuing challenges for providing consistently high-quality care. Medicare's Final Rule of the Conditions for Coverage (April 2008) define the medical director of the dialysis center as the leader of the interdisciplinary team and the person ultimately accountable for quality, safety, and care provided in the center. Knowledge and active leadership with a hands-on approach in the quality assessment and performance improvement process (QAPI) is essential for the achievement of high-quality outcomes in dialysis centers. A collaborative approach between the dialysis provider and medical director is required to optimize outcomes and deliver evidence-based quality care. In 2011 the Centers for Medicare & Medicaid Services introduced a pay-for-performance program-the ESRD quality incentive program (QIP)- with yearly varying quality metrics that result in payment reductions in subsequent years when targets are not achieved during the performance period. Success with the QIP requires a clear understanding of the structure, metrics, and scoring methods. Information on achievement and nonachievement is publicly available, both in facilities (through the facility performance score card) and on public websites (including Medicare's Dialysis Facility Compare). By assuming the leadership role in the quality program of dialysis facilities, the medical

  3. A DUAL NETWORK MODEL OF INTERLOCKING DIRECTORATES

    Directory of Open Access Journals (Sweden)

    Humphry Hung

    2003-01-01

    Full Text Available The article proposes an integrative framework for the study of interlocking directorates by using an approach that encompasses the concepts of multiple networks and resource endowment. This serves to integrate the traditional views of interorganizational linkages and intra-class cohesion. Through appropriate strategic analysis of relevant resource endowment of internal environment and external networks of organizations and corporate elites, this article argues that the selection of directors, if used effectively, can be adopted as a strategic device to enhance the corporation's overall performance.

  4. Rolf-Dieter Heuer, next Director General

    CERN Multimedia

    CERN Council appointed Professor Rolf-Dieter Heuer to succeed Dr Robert Aymar as CERN’s Director General. Professor Heuer will serve a five-year term, taking office on 1 January 2009. Rolf-Dieter Heuer is currently Research Director for particle and astroparticle physics at Germany’s DESY laboratory in Hamburg. He was a staff member at CERN from 1984 to 1998, working for the OPAL collaboration at LEP, and from 1994 to 1998 he was the collaboration’s spokesman. See the Press Release.

  5. Staphylococcus aureus, evolución de un viejo patógeno

    Directory of Open Access Journals (Sweden)

    Ileana Álvarez Lam

    2012-12-01

    Full Text Available El Staphylococcus aureus está considerado uno de los microorganismos más importantes en la práctica médica diaria. Es capaz de provocar una amplia gama de enfermedades, ya sea por acción directa o mediante la acción de sus toxinas. El tratamiento de estas infecciones se ha convertido en algo extraordinariamente complejo en la época actual como consecuencia de la aparición en la comunidad de cepas de S. aureus, resistentes a la meticillina, que provocan infecciones en pacientes sin factores de riesgo, fundamentalmente niños y adolescentes. En este artículo se hace una revisión, que va desde los cambios en la epidemiología de este patógeno, hasta las implicaciones que para el tratamiento médico presupone este fenómeno.

  6. PatMaN: rapid alignment of short sequences to large databases.

    Science.gov (United States)

    Prüfer, Kay; Stenzel, Udo; Dannemann, Michael; Green, Richard E; Lachmann, Michael; Kelso, Janet

    2008-07-01

    We present a tool suited for searching for many short nucleotide sequences in large databases, allowing for a predefined number of gaps and mismatches. The commandline-driven program implements a non-deterministic automata matching algorithm on a keyword tree of the search strings. Both queries with and without ambiguity codes can be searched. Search time is short for perfect matches, and retrieval time rises exponentially with the number of edits allowed. The C++ source code for PatMaN is distributed under the GNU General Public License and has been tested on the GNU/Linux operating system. It is available from http://bioinf.eva.mpg.de/patman. Supplementary data are available at Bioinformatics online.

  7. "Anything That Gets Me in My Heart": Pat Parker's Poetry of Justice.

    Science.gov (United States)

    Green, David B

    2015-01-01

    This article argues that love and justice are interlocking themes that undergird and motivate the poetry and activism of the Black lesbian feminist Pat Parker. Parker was a prolific working-class poet, a committed Black lesbian feminist, and an international trailblazer whose poems, like her famous "Womanslaughter" discussed in this article, document the many injustices that Black women endured in an anti-Black, rabidly homophobic, and patriarchal U.S. during the last decades of the twentieth century. In a political moment where righteous cries of #BlackLivesMatter are heard across the United States I use this article to remind us all of the historical importance that Black lesbians played and continue to play in the struggles of anti-racist justice in America.

  8. Evaluación de patógenos en clones de lulo (Solanum quitoense Lam.

    Directory of Open Access Journals (Sweden)

    Consuelo Montes Rojas

    2010-04-01

    Full Text Available En el noroccidente de Popayán, Colombia, se evaluó la presencia de plagas causadas por patógenos en 42 clones de lulo (Solanum quitoense Lam.. Los clones fueron plantados en bolsas plásticas, donde se desarrollaron por 3 semanas antes de ser trasplantados al campo. Se utilizó un diseño de bloques completos al azar con cuatro repeticiones, la parcela útil estuvo conformada por 6 plantas, las cuales se sembraron a ‘tresbolillo’ a 2.5 m entre surcos y 2 m entre plantas. Para determinar el efecto de las plagas en el cultivo, se calculó el porcentaje de incidencia y severidad del ataque. La incidencia se evaluó como porcentaje de plantas afectadas, y la severidad como porcentaje de tejido afectado por el patógeno. Las enfermedades más limitantes para los 42 clones fueron: gota (Phytophthora infestans que provocó una mortalidad de plantas superior a 40%; fusarium (Fusarium oxysporum que se presentó en 12 de los clones evaluados; antracnosis (Colletotrichum sp. que afectó 21 clones, los cuales se clasificaron entre tolerantes y medianamente tolerantes; y mancha clorótica (Cladosporium sp. que afectó 21 clones, clasificados como susceptibles. Los clones PL19, PL24, PL11, PL35 fueron medianamente tolerantes. Se seleccionaron por supervivencia los clones: JY E1 (52.2%, PH E 1 (45.8%, VM E2 (45.8%; por supervivencia y por tolerancia a Fusarium oxysporum los clones PL35, PL11, PL24, PL8, PL19, 120052, 120043, ORE1, AGE1. Los clones SER 7, SER 15, SER 9, SEC 31, SEC 27 presentaron alta mortalidad pero se seleccionaron por ser medianamente tolerantes a gota, tolerantes a antracnosis y medianamente resistentes a nematodos, con buen vigor y producción.

  9. Analytical/experimental methods supporting an ``error budget``-based design of the PATS/PFMS

    Energy Technology Data Exchange (ETDEWEB)

    Bennett, J.G.; Rhorer, R.L.; Stevens, R.R.

    1992-09-01

    The design of a Precision Automated Turning System (PATS) for use in the Department of Energy weapons complex is being carried out under the umbrella of the Precision Flexible Manufacturing System (PFMS) at the Los Alamos National Laboratory. From the beginning of this project, the design has been based on a finished part ``error budget`` concept that allows the contribution of the elastic displacements from the PATS machine-base to be included in the machining error and the spindle-to-spindle part transfer error. Thus, a number of different analytical models have been used to perform studies of the displacements of key points when the base is subjected to the loadings that occur during movement of the slides on the way system. Finite Element (FE) models have been used in parameter studies. This model has pointer ``beams`` at the part-machining position along the spindle centerline and at the spindle-to-spindle part transfer position. These rigid pointers indicate the difference in the actual displacements, as opposed to the assumed displacements (thus, the `error), at these points caused by the base deformation. For example, one of their uses was to study the effects of the locations and the number of base supports. The maximum relative pointer displacements, when the model is loaded by the way system for 3, 6, 11, and a crippled 11 -point support scheme, were studied. Using this information, a decision was made to depart from the conventional 3-point (``milkstool``) support concept, and support the base at 5-points.

  10. Computation Directorate 2008 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Crawford, D L

    2009-03-25

    Whether a computer is simulating the aging and performance of a nuclear weapon, the folding of a protein, or the probability of rainfall over a particular mountain range, the necessary calculations can be enormous. Our computers help researchers answer these and other complex problems, and each new generation of system hardware and software widens the realm of possibilities. Building on Livermore's historical excellence and leadership in high-performance computing, Computation added more than 331 trillion floating-point operations per second (teraFLOPS) of power to LLNL's computer room floors in 2008. In addition, Livermore's next big supercomputer, Sequoia, advanced ever closer to its 2011-2012 delivery date, as architecture plans and the procurement contract were finalized. Hyperion, an advanced technology cluster test bed that teams Livermore with 10 industry leaders, made a big splash when it was announced during Michael Dell's keynote speech at the 2008 Supercomputing Conference. The Wall Street Journal touted Hyperion as a 'bright spot amid turmoil' in the computer industry. Computation continues to measure and improve the costs of operating LLNL's high-performance computing systems by moving hardware support in-house, by measuring causes of outages to apply resources asymmetrically, and by automating most of the account and access authorization and management processes. These improvements enable more dollars to go toward fielding the best supercomputers for science, while operating them at less cost and greater responsiveness to the customers.

  11. Michel Spiro is appointed director of the IN2P3 and the Department of Nuclear and Particle Physics of the CNRS

    CERN Document Server

    2003-01-01

    "Michel Spiro was appointed director of the IN2P3, by order of the Minister of Youth, National Education and Research and the Minister of Research and New Technologies on February 17, 2003. He was also appointed director of the Department of Nuclear and Particle Physics of the CNRS by decision of the CNRS Director General on February 21, 2003" (1/2 page).

  12. Potential anxiolytic properties of R-(+)-8-OSO2CF3-PAT, a 5-HT1A receptor agonist

    NARCIS (Netherlands)

    Barf, T; Korte, SM; KorteBouws, G; Sonesson, C; Damsma, G; Bohus, B; Wikstrom, H

    1996-01-01

    The anxiolytic property of R-(+)-8-OSO3CF3-PAT (R-(+)-8-[[(trifluoromethyl)sulfonyl]oxy]-2-(n-propyl-amino)tetralin), a 5-HT1A receptor agonist, was evaluated in Wistar rats by means of animal models of anxiety, the conditioned defensive burying model and the conditioned stress-induced freezing resp

  13. Board of directors and risk management

    NARCIS (Netherlands)

    van der Elst, C.F.; Birkmose, H.; Neville, M.; Sorensen, K.

    2013-01-01

    The board of directors is responsible for an appropriate business risk management environment. The paper studies in a comparative way how legislators and courts fill this duty. We question whether the legislative and regulatory framework will improve the equilibrium between entrepreneurship and risk

  14. 7 CFR 48.3 - Director.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Director. 48.3 Section 48.3 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE MARKETING OF PERISHABLE AGRICULTURAL COMMODITIES REGULATIONS OF...

  15. Female Special Education Directors: Doubly Marginalized.

    Science.gov (United States)

    Keefe, Charlotte Hendrick; Parmley, Pamela

    2003-01-01

    A qualitative study of five Texas female special education directors found that although participants achieved an administrative position, they were marginalized due to their leadership style, gender discrimination, and socialization. Participants also indicated a negative connection between being in special education administration and top-level…

  16. Overseas Programs: Suggestions for a Director.

    Science.gov (United States)

    Goldin, David

    1984-01-01

    Offers insights and advice for anyone contemplating a director's position in an overseas study program. In addition to stressing that the goals of the program be well-defined and well-planned, the importance of offering the exchange students a complete, integrated exposure to the language and culture of the host country is stressed. (SL)

  17. VMware vCloud Director essentials

    CERN Document Server

    Pal, Lipika

    2014-01-01

    If you are a technical professional with system administration knowledge, then this book is for you. The book also covers areas of importance if you are a virtualization engineer, consultant, architect, senior system engineer, or senior system analyst. You should possess core vSphere platform knowledge necessary to serve as a base to learn vCloud Director and its associated components.

  18. Movie Director Bags a Silver Bear

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Chinese director and film writer Wang Xiaoshuai has walked away with the Silver Bear award at the 58th Berlin International Film Festival for best script of Zuo You, or In Love We Trust. Back in 2001, Wang won his first Silver Bear award for directing Beijing

  19. Board of directors and risk management

    NARCIS (Netherlands)

    van der Elst, C.F.; Birkmose, H.; Neville, M.; Sorensen, K.

    2013-01-01

    The board of directors is responsible for an appropriate business risk management environment. The paper studies in a comparative way how legislators and courts fill this duty. We question whether the legislative and regulatory framework will improve the equilibrium between entrepreneurship and risk

  20. 75 FR 6642 - Notice of Proposed Information Collection; Naval Special Warfare Recruiting Directorate

    Science.gov (United States)

    2010-02-10

    ..., including through the use of automated collection techniques or other forms of information technology. DATES... overall compatibility between individuals interested in potentially pursuing a career as a Navy Sea Air... Recruiting Directorate to provide appropriate career and training preparation information to prospective...

  1. Addressing the process improvement science knowledge and skills of program directors and associate program directors.

    Science.gov (United States)

    Gravdal, Judith A; Hyziak, Pamela; Belmonte, Frank; Clemens, Mary Ann; Sulo, Suela

    2015-01-01

    Process improvement (PI) science is relatively new to healthcare and has only recently been introduced to medical education. Most residency faculty lack training or experience in PI science activities. We assessed the impact of PI science education on the knowledge and attitudes of a group of residency and fellowship program directors and associate program directors using their respective Accreditation Council for Graduate Medical Education annual program evaluations (APEs) as an experiential object. For this pre/post study, 16 program directors and 7 associate program directors were surveyed before and after 4 didactic modules. The APEs for the 2 years prior to the intervention and in the fall after the intervention were analyzed. Mentoring in the use of these skills in the preparation of the APEs was provided. The participants demonstrated improved knowledge in some areas and increased awareness of deficits in other areas. APE quality did not show consistent improvement following the intervention. The PI science knowledge and skill gaps of program directors and associate program directors are likely to impact the content and success of residency curricula. The designed PI science curriculum was slightly effective. Using the APE as the experiential object was convenient, but the APE was not the best project for a PI exercise. New, effective strategies and interventions to develop expertise in PI science are important as programs grapple with meeting new requirements, ensuring quality programs, and preparing residents and fellows for practice.

  2. Identifying influential directors in the United States corporate governance network

    Science.gov (United States)

    Huang, Xuqing; Vodenska, Irena; Wang, Fengzhong; Havlin, Shlomo; Stanley, H. Eugene

    2011-10-01

    The influence of directors has been one of the most engaging topics recently, but surprisingly little research has been done to quantitatively evaluate the influence and power of directors. We analyze the structure of the US corporate governance network for the 11-year period 1996-2006 based on director data from the Investor Responsibility Research Center director database, and we develop a centrality measure named the influence factor to estimate the influence of directors quantitatively. The US corporate governance network is a network of directors with nodes representing directors and links between two directors representing their service on common company boards. We assume that information flows in the network through information-sharing processes among linked directors. The influence factor assigned to a director is based on the level of information that a director obtains from the entire network. We find that, contrary to commonly accepted belief that directors of large companies, measured by market capitalization, are the most powerful, in some instances, the directors who are influential do not necessarily serve on boards of large companies. By applying our influence factor method to identify the influential people contained in the lists created by popular magazines such as Fortune, Networking World, and Treasury and Risk Management, we find that the influence factor method is consistently either the best or one of the two best methods in identifying powerful people compared to other general centrality measures that are used to denote the significance of a node in complex network theory.

  3. Identifying influential directors in the United States corporate governance network.

    Science.gov (United States)

    Huang, Xuqing; Vodenska, Irena; Wang, Fengzhong; Havlin, Shlomo; Stanley, H Eugene

    2011-10-01

    The influence of directors has been one of the most engaging topics recently, but surprisingly little research has been done to quantitatively evaluate the influence and power of directors. We analyze the structure of the US corporate governance network for the 11-year period 1996-2006 based on director data from the Investor Responsibility Research Center director database, and we develop a centrality measure named the influence factor to estimate the influence of directors quantitatively. The US corporate governance network is a network of directors with nodes representing directors and links between two directors representing their service on common company boards. We assume that information flows in the network through information-sharing processes among linked directors. The influence factor assigned to a director is based on the level of information that a director obtains from the entire network. We find that, contrary to commonly accepted belief that directors of large companies, measured by market capitalization, are the most powerful, in some instances, the directors who are influential do not necessarily serve on boards of large companies. By applying our influence factor method to identify the influential people contained in the lists created by popular magazines such as Fortune, Networking World, and Treasury and Risk Management, we find that the influence factor method is consistently either the best or one of the two best methods in identifying powerful people compared to other general centrality measures that are used to denote the significance of a node in complex network theory.

  4. The director of medical informatics: a new physician leader for IT initiatives.

    Science.gov (United States)

    Malloy, J M; Benoit, T A

    1998-10-01

    Integrated delivery systems (IDSs) recently have invested substantial financial resources in information technology (IT) initiatives. But the return on that investment for many IDSs in terms of improved productivity and reduced costs has been less than anticipated. Therefore, to improve or enhance the success of IT initiatives, some IDSs have sought to encourage more physician support of such efforts by creating a new executive position--director of medical informatics--designed to be filled by physician leaders who have knowledge and skill in managing information systems. The director of medical informatics, who typically reports to the CEO or CIO, coordinates IT initiatives that address physician concerns and promotes physician buy-in.

  5. 22 May 2009 - HRH the Duke of Kent, United Kingdom of Great Britain and Northern Ireland, visiting CMS underground area and CERN Control Center with Director for Accelerators and Technology S. Myers and Senior Physicist and STFC Board Member J. Ellis.

    CERN Multimedia

    Maximilien Brice

    2009-01-01

    Tirage 1 to 11:Signature of the guest book with the Director-General, R. Heuer Tirage 12 to 25:CMS underground experimental area with Spokesperson, T. Virdee Tirage 26 to 35:CCC with P. Collier and D. Nisbet

  6. Interview with Steve Myers, Director for Accelerators and Technology

    CERN Multimedia

    CERN Video Productions

    2009-01-01

    Questions : 1. After a year of repairs and consolidation work, is the LHC now ready for data? 2. Is the LHC more difficult to run compared to other existing or previous particle accelerators? Why? 3. When do you expect to be running at 7 TeV? 4. What is exactly going to happen in the control room in the next few days?

  7. Evaluación de patógenos en clones de lulo (Solanum quitoense Lam.

    Directory of Open Access Journals (Sweden)

    Montes Rojas Consuelo

    2010-06-01

    Full Text Available

    En el noroccidente de Popayán, Colombia, se evaluó la presencia de plagas causadas por patógenos en 42 clones de lulo (Solanum quitoense Lam.. Los clones fueron plantados en bolsas plásticas, donde se desarrollaron por 3 semanas antes de ser trasplantados al campo. Se utilizó un diseño de bloques completos al azar con cuatro repeticiones, la parcela útil estuvo conformada por 6 plantas, las cuales se sembraron a 'tresbolillo' a 2.5 m entre surcos y 2 m entre plantas. Para determinar el efecto de las plagas en el cultivo, se calculó el porcentaje de incidencia y severidad del ataque. La incidencia se evaluó como porcentaje de plantas afectadas, y la severidad como porcentaje de tejido afectado por el patógeno. Las enfermedades más limitantes para los 42 clones fueron: gota (Phytophthora infestans que provocó una mortalidad de plantas superior a 40%; fusarium (Fusarium oxysporum que se presentó en 12 de los clones evaluados; antracnosis (Colletotrichum sp. que afectó 21 clones, los cuales se clasificaron entre tolerantes y medianamente tolerantes; y mancha clorótica (Cladosporium sp. que afectó 21 clones, clasificados como susceptibles. Los clones PL19, PL24, PL11, PL35 fueron medianamente tolerantes. Se seleccionaron por supervivencia los clones: JY E1 (52.2%, PH E 1 (45.8%, VM E2 (45.8%; por supervivencia y por tolerancia a Fusarium oxysporum los clones PL35, PL11, PL24, PL8, PL19, 120052, 120043, ORE1, AGE1. Los clones SER 7, SER 15, SER 9, SEC 31, SEC 27 presentaron alta mortalidad pero se seleccionaron por ser medianamente tolerantes a gota, tolerantes a antracnosis y medianamente resistentes a nematodos, con buen vigor y producción.

  8. Emotional intelligence model for directors of research centers in mexico

    Directory of Open Access Journals (Sweden)

    Mara Maricela Trujillo Flores

    2008-01-01

    H5 Social skills exhibited by directors, that are also part of interpersonal intelligence, allow a director to exert a greater influence on the working group, facilitating communication, conflict management, leadership, collaboration, cooperation and development of team skills.

  9. Dr. William C. Harris, Director-General, Science Foundation Ireland

    CERN Multimedia

    Maximilien Brice

    2002-01-01

    Photo 01: Dr William C. Harris, Director-General, Science Foundation Ireland (left) with R. Cashmore. Photos 02, 03: Dr William C. Harris, Director-General, Science Foundation Ireland signing the CERN guest book with R. Cashmore.

  10. UNC Cancer Center Director to Lead NCI.

    Science.gov (United States)

    2017-08-01

    President Donald Trump has selected Norman "Ned" Sharpless, MD, director of the University of North Carolina Lineberger Comprehensive Cancer Center, to lead the NCI. The news was met with widespread approval among cancer researchers, who view Sharpless as a strong communicator who can ably represent the needs of the cancer community in the face of proposed funding cuts. ©2017 American Association for Cancer Research.

  11. OSG Director reports on grid progress

    CERN Multimedia

    Pordes, Ruth

    2006-01-01

    "In this Q&A from the Open Science Grid (OSG), executive director Ruth Prodes provides a brief history of the OSG, an overview of current projects and partners, and a glimpse at future plans, including how the recent $30 million award from the ODE's office of Science and the NSF will be employed. She also shares her thoughts of SC, saying the personal contacts are the best part."(4,5 pages)

  12. 76 FR 70970 - Technology Innovation Program Advisory Board

    Science.gov (United States)

    2011-11-16

    ... National Institute of Standards and Technology Technology Innovation Program Advisory Board AGENCY.... SUMMARY: The Technology Innovation Program (TIP) Advisory Board will hold a meeting via teleconference on... Innovation Program Acting Deputy Director, National Institute of Standards and Technology, 100 Bureau...

  13. Survey of international regional anesthesia fellowship directors

    Directory of Open Access Journals (Sweden)

    Lansdown AK

    2013-07-01

    Full Text Available Andrew K Lansdown,1,2 Paul G McHardy,1 Sanjiv C Patel,1,3 Catherine M Nix,1 Colin JL McCartney1 1Department of Anesthesia, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada; 2University of Sydney, Sydney, NSW, Australia; 3University College Hospital, London, UK Background: The scope of regional anesthesia fellowship programs has not been analyzed but may provide insights that could improve fellowship training and standards. Methods: Regional anesthesia fellowship directors across the world were asked to complete a comprehensive survey that detailed the range of educational and practical experience and attitudes as well as assessment procedures offered in their programs. Results: The survey response rate was 66% (45/68. Overall, the range of activities and the time and resources committed to education during fellowships is encouraging. A wide range of nerve block experience is reported with most programs also offering acute pain management, research, and teaching opportunities. Only two-thirds of fellowships provide formal feedback. This feedback is typically a formative assessment. Conclusion: This is the first survey of regional anesthesia fellowship directors, and it illustrates the international scope and continuing expansion of education and training in the field. The results should be of interest to program directors seeking to benchmark and improve their educational programs and to faculty involved in further curriculum development. Keywords: anesthesia, regional, fellowship, education

  14. Stretching Your Technology Dollar

    Science.gov (United States)

    Johnson, Doug

    2012-01-01

    A school district technology director offers 10 strategies to help schools make the most of their technology dollar. These include using effective budgeting techniques, taking advantage of the buying power of groups, practicing sustainable technology, purchasing the right tool for the right job, taking advantage of free software, using cloud…

  15. Stretching Your Technology Dollar

    Science.gov (United States)

    Johnson, Doug

    2012-01-01

    A school district technology director offers 10 strategies to help schools make the most of their technology dollar. These include using effective budgeting techniques, taking advantage of the buying power of groups, practicing sustainable technology, purchasing the right tool for the right job, taking advantage of free software, using cloud…

  16. Photon activated therapy (PAT using monochromatic Synchrotron x-rays and iron oxide nanoparticles in a mouse tumor model: feasibility study of PAT for the treatment of superficial malignancy

    Directory of Open Access Journals (Sweden)

    Choi Gi-Hwan

    2012-10-01

    Full Text Available Abstract Background X-rays are known to interact with metallic nanoparticles, producing photoelectric species as radiosensitizing effects, and have been exploited in vivo mainly with gold nanoparticles. The purpose of this study was to investigate the potential of sensitizing effect of iron oxide nanoparticles for photon activated therapy. Methods X-rays photon activated therapy (PAT was studied by treating CT26 tumor cells and CT26 tumor-bearing mice loaded with 13-nm diameter FeO NP, and irradiating them at 7.1 keV near the Fe K-edge using synchrotron x-rays radiation. Survival of cells was determined by MTT assay, and tumor regression assay was performed for in vivo model experiment. The results of PAT treated groups were compared with x-rays alone control groups. Results A more significant reduction in viability and damage was observed in the FeO NP-treated irradiated cells, compared to the radiation alone group (p Conclusions An iron oxide nanoparticle enhanced therapeutic effect with relatively low tissue concentration of iron and 10 Gy of monochromatic X-rays. Since 7.1 keV X-rays is attenuated very sharply in the tissue, FeO NP-PAT may have promise as a potent treatment option for superficial malignancies in the skin, like chest wall recurrence of breast cancer.

  17. Building Identity in Collegiate Midlevel Choral Ensembles: The Director's Perspective

    Science.gov (United States)

    Major, Marci L.

    2017-01-01

    This study was designed to explore the director's perspective on the role organizational images play in social identity development in midlevel choral ensembles. Using a phenomenological methodology, I interviewed 10 current or former directors of midlevel choral ensembles from eight midwestern U.S. colleges and universities. Directors cited…

  18. 19 CFR 151.74 - Retest at port director's request.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Retest at port director's request. 151.74 Section 151.74 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT... Retest at port director's request. If the port director is not satisfied with the results of any...

  19. 7 CFR 7.25 - County executive director duties.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false County executive director duties. 7.25 Section 7.25... CONSERVATION STATE, COUNTY AND COMMUNITY COMMITTEES § 7.25 County executive director duties. (a) The county executive director shall execute the policies established by the county committee and be responsible for...

  20. 20 CFR 702.272 - Informal recommendation by district director.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Informal recommendation by district director... Procedures Discrimination § 702.272 Informal recommendation by district director. (a) If the district... employee accept the district director's recommendation, it will be incorporated in an order and mailed...

  1. 12 CFR 1261.12 - Reporting requirements for Bank directors.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Reporting requirements for Bank directors. 1261.12 Section 1261.12 Banks and Banking FEDERAL HOUSING FINANCE AGENCY FEDERAL HOME LOAN BANKS FEDERAL HOME LOAN BANK DIRECTORS Federal Home Loan Bank Boards of Directors: Eligibility and Elections §...

  2. 12 CFR 1261.10 - Independent director conflict of interests.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Independent director conflict of interests. 1261.10 Section 1261.10 Banks and Banking FEDERAL HOUSING FINANCE AGENCY FEDERAL HOME LOAN BANKS FEDERAL HOME LOAN BANK DIRECTORS Federal Home Loan Bank Boards of Directors: Eligibility and...

  3. 12 CFR 1261.13 - Ineligible Bank directors.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Ineligible Bank directors. 1261.13 Section 1261.13 Banks and Banking FEDERAL HOUSING FINANCE AGENCY FEDERAL HOME LOAN BANKS FEDERAL HOME LOAN BANK DIRECTORS Federal Home Loan Bank Boards of Directors: Eligibility and Elections § 1261.13 Ineligible...

  4. 7 CFR 2.34 - Director, National Appeals Division.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Director, National Appeals Division. 2.34 Section 2.34... Heads § 2.34 Director, National Appeals Division. The Director, National Appeals Division, under the... officers and other employees as are necessary for the administration of the activities of the Division....

  5. 7 CFR 2.95 - Director, Office of Ethics.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Director, Office of Ethics. 2.95 Section 2.95... Administration § 2.95 Director, Office of Ethics. The Director, Office of Ethics, shall be the USDA Alternate Agency Ethics Official, pursuant to 5 CFR 2638.202, and shall exercise the authority reserved to...

  6. PAT Design Strategy for Energy Recovery in Water Distribution Networks by Electrical Regulation

    Directory of Open Access Journals (Sweden)

    Helena M. Ramos

    2013-01-01

    Full Text Available In the management of water distribution networks, large energy savings can be yielded by exploiting the head drop due to the network pressure control strategy, i.e., for leak reductions. Hydropower in small streams is already exploited, but technical solutions combining efficiency and economic convenience are still required. In water distribution networks, an additional design problem comes out from the necessity of ensuring a required head drop under variable operating conditions, i.e., head and discharge variations. Both a hydraulic regulation (HR—via a series-parallel hydraulic circuit- and an electrical regulation (ER—via inverter- are feasible solutions. A design procedure for the selection of a production device in a series-parallel hydraulic circuit has been recently proposed. The procedure, named VOS (Variable Operating Strategy, is based on the overall plant efficiency criteria and is applied to a water distribution network where a PAT (pump as a turbine is used in order to produce energy. In the present paper the VOS design procedure has been extended to the electrical regulation and a comparison between HR and ER efficiency and flexibility within a water distribution network is shown: HR was found more flexible than ER and more efficient. Finally a preliminary economic study has been carried out in order to show the viability of both systems, and a shorter payback period of the electromechanical equipment was found for HR mode.

  7. Extratos vegetais no controle de patógenos em sementes de Pterogyne nitens Tul

    Directory of Open Access Journals (Sweden)

    José George Ferreira Medeiros

    Full Text Available A demanda por sementes florestais para reflorestamento e outras finalidades poderá se constituir em um meio de disseminação de patógenos, que podem comprometer a qualidade fisiológica das sementes. Assim, objetivou-se avaliar o efeito de extratos naturais de melão-de-são-caetano (Momordica charantia e alamanda (Allamanda blanchetti sobre a micoflora e a fisiologia de sementes de Pterogyne nitens. Os seguintes tratamentos fitossanitários foram avaliados: testemunha (sementes não tratadas; fungicida Captan® (240 g/100 kg, e extratos de melão-de-são-caetano e alamanda nas concentrações de 10, 100, 500 e 1000 ppm. No teste de germinação, avaliaram-se a porcentagem de germinação, a primeira contagem e o índice de velocidade de germinação (IVG. Os extratos vegetais de melão-de-são-caetano e alamanda reduziram a incidência de fungos e aumentaram o percentual de germinação das sementes de P. nitens.

  8. Investigating Trauma in Narrating World War I: A Psychoanalytical Reading of Pat Barker’s Regeneration

    Directory of Open Access Journals (Sweden)

    Bakhtiar Sadjadi

    2016-12-01

    Full Text Available The present paper seeks to critically read Pat Barker’s Regeneration in terms of Cathy Caruth’s psychoanalytic study of trauma. This analysis attempts to trace the concepts of latency, post-traumatic stress disorders, traumatic memory, and trauma in Barker’s novel in order to explore how trauma and history are interrelated in the narrative of past history and, particularly, in the history of World War I. The present paper also demonstrates how Barker’s novel Regeneration acts as the narrative of trauma that vocalizes the silenced history of shell-shocked soldiers of World War I to represent British society, the history that has been concealed due to social and individual factors. The study thus investigates the dissociative disorders which are experienced by traumatized survivors of World War I as the aftermath of traumatic experiences of wartime. In addition, it argues how time moves for the traumatized victim and how the notion of latency in terms of Caruth’s theory is traceable in Barker’s novel. In Regeneration, the traumatized survivors are haunted with traumatic memory of past history; furthermore, past history constantly disrupts their present and the victims are in continuous shift from present time to past time. Time thus loses its linearity in the narrative of traumatized survivors. Keywords: Latency, post-traumatic stress disorders, traumatic memory, trauma

  9. Allied health deans' and program directors' perspectives of specialized accreditation effectiveness and reform.

    Science.gov (United States)

    Baker, Sarah S; Morrone, Anastasia S; Gable, Karen E

    2004-01-01

    Criticisms, calls for change, and recommendations for specialized accreditation improvement have been made by individuals or groups external to the daily operations of allied health educational programs, frequently as opinion pieces or articles lacking a research foundation. While there is a great deal of concern related to specialized accreditation, little input has been provided from those within, and integral to, allied health educational programs affected by specialized accreditation standards. The purpose of this study was to explore the perspectives of selected allied health deans and program directors regarding specialized accreditation effectiveness and reform. Survey research was used to study perspectives of allied health deans and program directors located in four-year colleges and universities and in academic health centers and medical schools. Surveys were mailed to program directors offering-programs in clinical laboratory sciences and medical technology, nuclear medicine technology, occupational therapy, physical therapy, radiation therapy, and radiography. Simultaneously, allied health deans located within these institutions were surveyed. A total of 773 surveys were mailed and 424 valid responses were received, yielding a response rate of 55%. The results affirmed the role of accreditation as an effective system for assuring quality in higher education. The role of specialized accreditation in improving the quality of allied health programs was clearly articulated by the respondents. Respondents voiced strong opposition to governmental or state-level requirements for accountability and emphasized the vital role of peer evaluators. Significant differences in deans' and program directors' perspectives related to specialized accreditation were evident. Whereas deans and program directors agreed with the purposes of specialized accreditation, they expressed less support for the process and effectiveness, and critique and reform, of specialized

  10. Prevenção da transmissão de patógenos por manipuladores de alimentos

    OpenAIRE

    Conceição, Mirza de Souza; Faculdade Redentor; Nascimento, Kamila de Oliveira do; UFRRJ

    2015-01-01

    O objetivo desta pesquisa foi investigar as formas de prevenção da transmissão de patógeno por manipuladores de alimentos. Este trabalho utilizou uma abordagem qualitativa, mediante uma pesquisa bibliográfica, utilizando dados secundários oriundos de publicações e resultados de pesquisas específicas sobre o assunto realizando uma síntese explicativa sobre a prevenção da transmissão de patógenos por manipuladores de alimentos. As doenças transmitidas por alimentos é uma preocupação de saúde pú...

  11. Effects of EPA and DHA on lipid droplet accumulation and mRNA abundance of PAT proteins in caprine monocytes.

    Science.gov (United States)

    Lecchi, Cristina; Invernizzi, Guido; Agazzi, Alessandro; Modina, Silvia; Sartorelli, Paola; Savoini, Giovanni; Ceciliani, Fabrizio

    2013-04-01

    The present study investigated the in vitro effects on caprine monocytes of two ω-3 PUFAs, namely eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on lipid droplet formation, an emerging process of fundamental importance in innate immunity regulation. The mRNA abundance of PAT protein family (PLIN1, PLIN2 and PLIN3), involved in the formation and trafficking of the droplets, was also assessed. The effects of EPA and DHA on monocyte apoptosis were studied as well. The number of lipid droplets per cell was found to be dependent on both type and concentration of fatty acid. ω-3 PUFAs upregulated PLIN3 and PLIN2 gene expression, as well as apoptosis rate. The present findings suggest that PUFA might modify innate immune functions of goat monocytes by interfering with the formation of lipid droplets and by upregulating proteins belonging to PAT protein family.

  12. Mentors or Directors of Thesis, is he author?

    Directory of Open Access Journals (Sweden)

    María das Graças TARGINO

    2014-07-01

    Full Text Available Over time, with the profound changes in the learning and in research provided by technological advances, and especially because of the extreme value of higher education and scientific research, there is an intense discussion around the old and worn slogan "publish or perish". Increasingly, mentors or directors of thesis and university papers, en general, put themselves as first author or coauthor of work performed by their students, by the argument that the author, as activity and process, suffers herself social, cultural, economic and political mutations. This is a topic that arouses controversy and leads to conceptual changes, which require the deconstruction of its foundations, which, however, must respect the ethic behaviour

  13. Comprehensive clinical studies in 34 patients with molecularly defined UPD(14)pat and related conditions (Kagami–Ogata syndrome)

    Science.gov (United States)

    Kagami, Masayo; Kurosawa, Kenji; Miyazaki, Osamu; Ishino, Fumitoshi; Matsuoka, Kentaro; Ogata, Tsutomu

    2015-01-01

    Paternal uniparental disomy 14 (UPD(14)pat) and epimutations and microdeletions affecting the maternally derived 14q32.2 imprinted region lead to a unique constellation of clinical features such as facial abnormalities, small bell-shaped thorax with a coat-hanger appearance of the ribs, abdominal wall defects, placentomegaly, and polyhydramnios. In this study, we performed comprehensive clinical studies in patients with UPD(14)pat (n=23), epimutations (n=5), and microdeletions (n=6), and revealed several notable findings. First, a unique facial appearance with full cheeks and a protruding philtrum and distinctive chest roentgenograms with increased coat-hanger angles to the ribs constituted the pathognomonic features from infancy through childhood. Second, birth size was well preserved, with a median birth length of ±0 SD (range, −1.7 to +3.0 SD) and a median birth weight of +2.3 SD (range, +0.1 to +8.8 SD). Third, developmental delay and/or intellectual disability was invariably present, with a median developmental/intellectual quotient of 55 (range, 29–70). Fourth, hepatoblastoma was identified in three infantile patients (8.8%), and histological examination in two patients showed a poorly differentiated embryonal hepatoblastoma with focal macrotrabecular lesions and well-differentiated hepatoblastoma, respectively. These findings suggest the necessity of an adequate support for developmental delay and periodical screening for hepatoblastoma in the affected patients, and some phenotypic overlap between UPD(14)pat and related conditions and Beckwith–Wiedemann syndrome. On the basis of our previous and present studies that have made a significant contribution to the clarification of underlying (epi)genetic factors and the definition of clinical findings, we propose the name ‘Kagami–Ogata syndrome' for UPD(14)pat and related conditions. PMID:25689926

  14. Comprehensive clinical studies in 34 patients with molecularly defined UPD(14)pat and related conditions (Kagami-Ogata syndrome).

    Science.gov (United States)

    Kagami, Masayo; Kurosawa, Kenji; Miyazaki, Osamu; Ishino, Fumitoshi; Matsuoka, Kentaro; Ogata, Tsutomu

    2015-11-01

    Paternal uniparental disomy 14 (UPD(14)pat) and epimutations and microdeletions affecting the maternally derived 14q32.2 imprinted region lead to a unique constellation of clinical features such as facial abnormalities, small bell-shaped thorax with a coat-hanger appearance of the ribs, abdominal wall defects, placentomegaly, and polyhydramnios. In this study, we performed comprehensive clinical studies in patients with UPD(14)pat (n=23), epimutations (n=5), and microdeletions (n=6), and revealed several notable findings. First, a unique facial appearance with full cheeks and a protruding philtrum and distinctive chest roentgenograms with increased coat-hanger angles to the ribs constituted the pathognomonic features from infancy through childhood. Second, birth size was well preserved, with a median birth length of ±0 SD (range, -1.7 to +3.0 SD) and a median birth weight of +2.3 SD (range, +0.1 to +8.8 SD). Third, developmental delay and/or intellectual disability was invariably present, with a median developmental/intellectual quotient of 55 (range, 29-70). Fourth, hepatoblastoma was identified in three infantile patients (8.8%), and histological examination in two patients showed a poorly differentiated embryonal hepatoblastoma with focal macrotrabecular lesions and well-differentiated hepatoblastoma, respectively. These findings suggest the necessity of an adequate support for developmental delay and periodical screening for hepatoblastoma in the affected patients, and some phenotypic overlap between UPD(14)pat and related conditions and Beckwith-Wiedemann syndrome. On the basis of our previous and present studies that have made a significant contribution to the clarification of underlying (epi)genetic factors and the definition of clinical findings, we propose the name 'Kagami-Ogata syndrome' for UPD(14)pat and related conditions.

  15. Transport of amino acids and GABA analogues via the human proton-coupled amino acid transporter, hPAT1

    DEFF Research Database (Denmark)

    Larsen, Mie; Larsen, Birger Brodin; Frølund, Bente

    2008-01-01

    The objective of this study was to investigate transepithelial amino acid transport as a function of Caco-2 cell culture time. Furthermore, the objective was to investigate apical uptake characteristics of hPAT1-mediated transport under various experimental conditions. Apical amino acid uptake......, which has been shown to function as a carboxylic acid bioisostere for substrates of the GABA receptor and transport systems....

  16. Chemistry and Materials Science Directorate Annual Report 2003

    Energy Technology Data Exchange (ETDEWEB)

    Diaz de la Rubia, T; Shang, S P; Kitrinos, G A; Fluss, M; Westbrook, C; Rennie, G

    2004-04-21

    Evolving challenges and solid accomplishments define the year 2003 for us. Our scientific breakthroughs validate our strategic directions and reaffirm our critical role in fulfilling the Laboratory's missions. Our growth continues in new research projects and significant new programmatic support. Our mission is clear: to enable the Laboratory to accomplish its primary mission through excellence in the chemical and materials sciences. The directorate's common theme and determination has remained constant: Deliver on our commitments, while anticipating and capitalizing on opportunities through innovation in science and technology. In this, the 2003 Annual Report, we describe how our science is built around a strategic plan with four organizing themes, each with key scientific accomplishments by our staff and collaborators. Our strategic plan is synergistic with the Laboratory's Long-Range Science and Technology Plan, which identifies six areas of institutional research and development strategy. This 2003 CMS Annual Report is organized into two major sections: research themes and dynamic teams. The research-theme section addresses challenges, achievements, and new frontiers within each of the four research themes. The dynamic-teams section illustrates the directorate's organizational structure of divisions, centers, and institutes that supports a team environment across disciplinary and institutional boundaries. The research presented gives substantive examples of how we are proceeding in each of these four theme areas and how they are aligned with the institutional strategy. Our organizational structure offers an environment of collaborative problem-solving opportunities, an environment that attracts and retains the best and the brightest from across the Laboratory and around the world.

  17. Eliminación de patógenos en biosólidos por estabilización alcalina

    Directory of Open Access Journals (Sweden)

    Patricia Torres Lozada

    2009-07-01

    Full Text Available La Planta de Tratamiento de Aguas Residuales de Cañaveralejo -PTAR-C de Cali- Colombia, produce alrededor de 100 t/día de biosólidos que, aunque no tienen restricción por metales pesados, son clase B por el nivel de microorganismos patógenos y parásitos. En un diseño completamente al azar, conformado por seis tratamientos con su respectivo duplicado, se evaluó la estabilización alcalina con dosis del 9% peso a peso de cal viva e hidratada, aplicada a pilas de 0.5 t de biosólidos húmedos (66.5% y secos a temperatura ambiente (25 - 31°C durante 72 h (humedad 50.1%. Con la estabilización alcalina el pH aumentó a valores superiores a 12 unidades durante el tiempo suficiente para garantizar la reducción de patógenos y parásitos, alcanzando un material clase A; sin embargo, el biosólido seco facilitó la formación de grumos que dificultaron las labores de homogenización del sustrato con los alcalinizantes, factor indeseable para la eficiente reducción de patógenos.

  18. Eliminación de patógenos en biosólidos por estabilización alcalina

    Directory of Open Access Journals (Sweden)

    Silva Leal Jorge Antonio

    2009-09-01

    Full Text Available La Planta de Tratamiento de Aguas Residuales de Cañaveralejo –PTAR-C de Cali– Colombia, produce alrededor de 100 t/día de biosólidos que, aunque no tienen restricción por metales pesados, son clase B por el nivel de microorganismos patógenos y parásitos. En un diseño completamente al azar, conformado por seis tratamientos con su respectivo duplicado, se evaluó la estabilización alcalina con dosis del 9% peso a peso de cal viva e hidratada, aplicada a pilas de 0.5 t de biosólidos húmedos (66.5% y secos a temperatura ambiente (25 - 31°C durante 72 h (humedad 50.1%. Con la estabilización alcalina el pH aumentó a valores superiores a 12 unidades durante el tiempo suficiente para garantizar la reducción de patógenos y parásitos, alcanzando un material clase A; sin embargo, el biosólido seco facilitó la formación de grumos que dificultaron las labores de homogenización del sustrato con los alcalinizantes, factor indeseable para la eficiente reducción de patógenos.

  19. The structure of the cyanobactin domain of unknown function from PatG in the patellamide gene cluster

    Energy Technology Data Exchange (ETDEWEB)

    Mann, Greg; Koehnke, Jesko; Bent, Andrew F.; Graham, Rachael [University of St Andrews, North Haugh, St Andrews, Fife KY16 8ST, Scotland (United Kingdom); Houssen, Wael [University of Aberdeen, Meston Walk, Aberdeen AB24 3UE, Scotland (United Kingdom); University of Aberdeen, Aberdeen AB25 2ZD, Scotland (United Kingdom); Mansoura University, Mansoura 35116 (Egypt); Jaspars, Marcel [University of Aberdeen, Meston Walk, Aberdeen AB24 3UE, Scotland (United Kingdom); Schwarz-Linek, Uli; Naismith, James H., E-mail: jhn@st-andrews.ac.uk [University of St Andrews, North Haugh, St Andrews, Fife KY16 8ST, Scotland (United Kingdom)

    2014-11-14

    The highly conserved domain of unknown function in the cyanobactin superfamily has a novel fold. The protein does not appear to bind the most plausible substrates, leaving questions as to its role. Patellamides are members of the cyanobactin family of ribosomally synthesized and post-translationally modified cyclic peptide natural products, many of which, including some patellamides, are biologically active. A detailed mechanistic understanding of the biosynthetic pathway would enable the construction of a biotechnological ‘toolkit’ to make novel analogues of patellamides that are not found in nature. All but two of the protein domains involved in patellamide biosynthesis have been characterized. The two domains of unknown function (DUFs) are homologous to each other and are found at the C-termini of the multi-domain proteins PatA and PatG. The domain sequence is found in all cyanobactin-biosynthetic pathways characterized to date, implying a functional role in cyanobactin biosynthesis. Here, the crystal structure of the PatG DUF domain is reported and its binding interactions with plausible substrates are investigated.

  20. Latvijas elektroenerģijas patēriņa ilgtermiņa prognozēšana

    OpenAIRE

    Bērziņš, Aivars

    2007-01-01

    Maģistra darbā apskatīti elektroenerģijas patēriņu raksturojošie rādītāji, veikta datu analīze, pētīti un analizēti elektroenerģijas patēriņu ietekmējošie faktori Latvijā, apskatītas pasaulē un Latvijā pielietojamās ilgtermiņa prognozēšanas metodes, analizētas konkrētas prognozes Latvijā. Veikta ekspertu aptauja, kā rezultātā iegūts ekspertu vidējais prognozētais elektroenerģijas patēriņš atskaites gados. Ar nelineārās daudzfaktoru eksponenciālās regresijas modeli aprēķināta Latvijas elektroe...

  1. 76 FR 13499 - Designation of Officers of the Office of the Director of National Intelligence To Act as Director...

    Science.gov (United States)

    2011-03-11

    ... National Intelligence To Act as Director of National Intelligence Memorandum for the Director of National Intelligence By the authority vested in me as President by the Constitution and the laws of the United States... the Office of the Director of National Intelligence named in section 2, in the order listed, shall...

  2. 78 FR 59159 - Designation of Officers of the Office of the Director of National Intelligence To Act as Director...

    Science.gov (United States)

    2013-09-25

    ... National Intelligence To Act as Director of National Intelligence Memorandum for the Director of National Intelligence By the authority vested in me as President by the Constitution and the laws of the United States... of the Office of the Director of National Intelligence, in the order listed, shall act as and...

  3. Technology.

    Science.gov (United States)

    Online-Offline, 1998

    1998-01-01

    Focuses on technology, on advances in such areas as aeronautics, electronics, physics, the space sciences, as well as computers and the attendant progress in medicine, robotics, and artificial intelligence. Describes educational resources for elementary and middle school students, including Web sites, CD-ROMs and software, videotapes, books,…

  4. Second person: Role-playing and story in games and playable media, edited by Pat Harrigan and Noah Wardrip-Fruin [book review

    Directory of Open Access Journals (Sweden)

    John Finlay Kerr

    2009-03-01

    Full Text Available Review of Pat Harrigan and Noah Wardrip-Fruin, eds. Second person: Role-playing and story in games and playable media. Cambridge, MA: MIT Press, 2008. $40 (408p ISBN 978-0-262-08356-0.

  5. Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes.

    Directory of Open Access Journals (Sweden)

    Margrét H Ögmundsdóttir

    Full Text Available Mammalian Target of Rapamycin Complex 1 (mTORC1 is activated by growth factor-regulated phosphoinositide 3-kinase (PI3K/Akt/Rheb signalling and extracellular amino acids (AAs to promote growth and proliferation. These AAs induce translocation of mTOR to late endosomes and lysosomes (LELs, subsequent activation via mechanisms involving the presence of intralumenal AAs, and interaction between mTORC1 and a multiprotein assembly containing Rag GTPases and the heterotrimeric Ragulator complex. However, the mechanisms by which AAs control these different aspects of mTORC1 activation are not well understood. We have recently shown that intracellular Proton-assisted Amino acid Transporter 1 (PAT1/SLC36A1 is an essential mediator of AA-dependent mTORC1 activation. Here we demonstrate in Human Embryonic Kidney (HEK-293 cells that PAT1 is primarily located on LELs, physically interacts with the Rag GTPases and is required for normal AA-dependent mTOR relocalisation. We also use the powerful in vivo genetic methodologies available in Drosophila to investigate the regulation of the PAT1/Rag/Ragulator complex. We show that GFP-tagged PATs reside at both the cell surface and LELs in vivo, mirroring PAT1 distribution in several normal mammalian cell types. Elevated PI3K/Akt/Rheb signalling increases intracellular levels of PATs and synergistically enhances PAT-induced growth via a mechanism requiring endocytosis. In light of the recent identification of the vacuolar H(+-ATPase as another Rag-interacting component, we propose a model in which PATs function as part of an AA-sensing engine that drives mTORC1 activation from LEL compartments.

  6. Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes.

    Science.gov (United States)

    Ögmundsdóttir, Margrét H; Heublein, Sabine; Kazi, Shubana; Reynolds, Bruno; Visvalingam, Shivanthy M; Shaw, Michael K; Goberdhan, Deborah C I

    2012-01-01

    Mammalian Target of Rapamycin Complex 1 (mTORC1) is activated by growth factor-regulated phosphoinositide 3-kinase (PI3K)/Akt/Rheb signalling and extracellular amino acids (AAs) to promote growth and proliferation. These AAs induce translocation of mTOR to late endosomes and lysosomes (LELs), subsequent activation via mechanisms involving the presence of intralumenal AAs, and interaction between mTORC1 and a multiprotein assembly containing Rag GTPases and the heterotrimeric Ragulator complex. However, the mechanisms by which AAs control these different aspects of mTORC1 activation are not well understood. We have recently shown that intracellular Proton-assisted Amino acid Transporter 1 (PAT1)/SLC36A1 is an essential mediator of AA-dependent mTORC1 activation. Here we demonstrate in Human Embryonic Kidney (HEK-293) cells that PAT1 is primarily located on LELs, physically interacts with the Rag GTPases and is required for normal AA-dependent mTOR relocalisation. We also use the powerful in vivo genetic methodologies available in Drosophila to investigate the regulation of the PAT1/Rag/Ragulator complex. We show that GFP-tagged PATs reside at both the cell surface and LELs in vivo, mirroring PAT1 distribution in several normal mammalian cell types. Elevated PI3K/Akt/Rheb signalling increases intracellular levels of PATs and synergistically enhances PAT-induced growth via a mechanism requiring endocytosis. In light of the recent identification of the vacuolar H(+)-ATPase as another Rag-interacting component, we propose a model in which PATs function as part of an AA-sensing engine that drives mTORC1 activation from LEL compartments.

  7. Federal role in science will grow, NSF Director predicts

    Science.gov (United States)

    Simarski, Lynn Teo

    1992-01-01

    Walter Massey, director of the National Science Foundation, recently called for a fundamental reassessment of the relationship between the federal government and research institutions. On January 15, Massey, now in his ninth month at NSF, described great changes in the government-university “partnership” since the “golden age” of the 1960s. Speaking in Washington, D.C. at a seminar of George Washington University's Center for International Science and Technology Policy, he predicted that his own term at the foundation would not be “business as usual.”Science and technology have shifted from being a peripheral concern of the government to a central policy issue, Massey said. The United States now sees science as too important to leave its agenda for scientists to set themselves. In response, the federal government is launching the initiatives of the Federal Coordinating Council for Science, Engineering, and Technology. Some of last year's FCCSET budget initiatives, spanning a number of federal agencies, dealt with math and science education, global change, and high-performance computing. Such programs “are research agenda put forth from the federal side—they are not things put forth from the [research] community,” Massey pointed out.

  8. Interview with Rolf Heuer, CERN Director General

    CERN Multimedia

    CERN Video Productions

    2009-01-01

    Questions : 1. How exciting is it for you to be the CERN Director General at a moment when the LHC is very close to producing data for the first time? 2. What do you expect the LHC to find at the assigned energy for this first run at 3.5 TeV per beam? What would be your best wish? 3. What are the chances that it discovers what you expext? 4. Can summarize the planning for the next few months? And later? 5. What is the historical importance of the LHC in scientific research in general? 6. What spin offs on society can we expect from the LHC?

  9. Oscars 2010:Kathryn Bigelow Wins Best Director

    Institute of Scientific and Technical Information of China (English)

    侍小军; 李新

    2010-01-01

    @@ "The Hurt Locker"defeated"Avatar"-the biggest movie of all time-to win Best Picture at the 82nd Academy Awards Sunday. "Hurt Locker" won five other Oscars,including,in a surprising main sweep,Best Director for Kathryn Bigelow. She made history as the first woman to receive the honor. Only three other women have been nominated(提名): Lina Wertmüller for "Seven Beauties",Jane Campion for "The Piano" and Sofia Coppola for "Lost in Translation".

  10. PLAN DIRECTOR URBANO DE SAN JOSÉ

    OpenAIRE

    Municipalidad de San José, Gobierno Local

    2011-01-01

    Este documento  resume el Plan Director Urbano del Cantòn Central de San José. Este Plan Urbano-Territorial ha sido diseñado como respuesta concreta del Gobierno Local, a la necesidad de regular y planificar el desarrollo general de la ciudad y el proceso de urbanización. Se incluye en un primer apartado una caracterización de la problemática y las tendencias urbanas josefinas; un segundo contenido se definen ls objetivos y líneas estratégicas de la ciudad que queremos. Un tercer apartado sob...

  11. Estudio geoeléctrico en el valle alto del Rio Patía

    Directory of Open Access Journals (Sweden)

    Pérez Cerón Rosalbina

    1995-10-01

    Full Text Available

    The resistivity survey carried out at the upper valley of the Patía River, provided good information to define the sedimentary sequence of the area. A general sequence from top to base is described as follows: recent deposits with resistivity values between 20 and 400 Ohrn-m, fine to medium grain, sandstones with resistivity values between 20 and 70 Ohrn-m, fine grain sandstones and silstones with resistivity values between 8 and 20 Ohrn-rn, and clayli basement, with resistivity less than 20 Ohm-m. There are two kinds of aquifers; free, related to sands and gravels from alluvial fans and terraces (resistivity values between 70 and 400 Ohrn-m and thickness between 25 and 75, semi-confined related to tertiary sandstones (resistivities values between 20 and 30 Ohm-m, thickness between 35 and 150 m. The water quality of the upper aquifers is good enough with small amounts of salt content. Saline water is found at the lower aquifer.

    The resistivity method was useful to locate geological discontinuities; some of them found with surface expression associated with lineaments and faults. Some of these geological features have been mapped in previous geological works on the area. In general the interpretation based on the resistivity results shows a block tectonics environment affecting cretaceous and tertiary rocks and probably the quaternary deposit.

    La prospección eléctrica en el valle alto del Rio Patía, permitió definir una secuencia típica constituida de techo a base por

  12. Implementation of an artificial neural network as a PAT tool for the prediction of temperature distribution within a pharmaceutical fluidized bed granulator.

    Science.gov (United States)

    Korteby, Yasmine; Mahdi, Yassine; Azizou, Amel; Daoud, Kamel; Regdon, Géza

    2016-06-10

    In this study, a novel in-line measurement technique of the air temperature distribution during a granulation process using a conical fluidized bed was designed and built for the purpose of measuring the temperature under the Process Analytical Technology (PAT) and introduced to predict the establishment of temperature profiles. Three sets of thermocouples were used, placed at different positions covering the whole operating range, connected to data acquisition measurement hardware, allowing an in-line acquisition and recording of temperatures every second. The measurements throughout the fluidized bed were performed in a steady state by spraying a solution of PVP onto a lactose monohydrate powder bed in order to make predictions of the temperature distribution and the hydrodynamics of the bed during the granulation process using Artificial Neural Networks (ANNs) and to establish the different temperature profiles for different process conditions through the precise predicted information by the constructed, trained, validated and tested neural network. The model's testing results showed a strong prediction capacity of the effects of process variables. Indeed, the predicted temperature values obtained with the ANN model were in good agreement with the values measured with in-line reference method and hence the method can have an application as a predictive control tool.

  13. Technology

    Directory of Open Access Journals (Sweden)

    Xu Jing

    2016-01-01

    Full Text Available The traditional answer card reading method using OMR (Optical Mark Reader, most commonly, OMR special card special use, less versatile, high cost, aiming at the existing problems proposed a method based on pattern recognition of the answer card identification method. Using the method based on Line Segment Detector to detect the tilt of the image, the existence of tilt image rotation correction, and eventually achieve positioning and detection of answers to the answer sheet .Pattern recognition technology for automatic reading, high accuracy, detect faster

  14. An interview with the Director-General

    CERN Multimedia

    James Gillies

    2012-01-01

    At its March meeting, the Council took the step of extending Rolf Heuer’s mandate until the end of 2015. What can we expect from the extra two years?   Extensions to Director-General’s mandates are few and far between, with the last being for Herwig Schopper, who served an eight-year term in the 1980s. For Rolf Heuer, the proposal was raised by the Belgian delegation, so we asked delegate Walter Van Doninck why the Council felt that circumstances warranted an extension now. “We felt that the LHC's first long shutdown needed management continuity, given the important nature of the work to be carried out,” he explained. “That’s why we proposed extending the mandate of the current Director-General.” James Gillies spoke to Professor Heuer to find out what he plans to achieve with the extra time. James Gillies: First of all, how do you feel about your time in office so far? Rolf Heuer: I feel I’m about midwa...

  15. A new director for Arts@CERN

    CERN Document Server

    CERN Bulletin

    2015-01-01

    On 2 March 2015, Mónica Bello will take the reins of the Arts@CERN programme. A few days before taking over the new job, the curator and art critic talked to the CERN Bulletin about her interest in arts and science, her motivations for the job, and her plans for the future of the programme.   Mónica Bello. “The exciting nature of CERN almost demands an artistic programme like Arts@CERN,” says Mónica, former artistic director of VIDA (one of the most important competitions in digital and new media arts worldwide), who has recently been appointed as the new director of the Arts@CERN programme. “The programme is unique as it provides the artist not only with resources, but also with interesting scientific topics and a natural way for the artists to become involved. Thanks to this programme, artists can come to CERN, bring their individuality, and really benefit from the sharing experience with scientists.” Mónica,...

  16. ELEMENTARY SCHOOL FIRST LEVEL STUDENTS’ METAPHORS ABOUT SCHOOL DIRECTORS

    Directory of Open Access Journals (Sweden)

    Demet ŞAHİN

    2014-06-01

    Full Text Available The purpose of the present study is to elicit elementary school first level students’ perceptions of the school director through drawings and metaphors. For this purpose, the students were asked to draw a painting depicting the school director and to generate metaphors related to the school director and vice director. The participants of the study were selected through easily accessible sampling method from two different elementary schools located in Kazan district of Ankara in 2012-2013 school year. In the analysis of the data, content analysis method was employed. The findings of the study revealed that usually the school director and vice director are considered together as the director of a school, they mostly described them in their offices and usually distant from the students and mostly in positive situations. All of the students using metaphors in their drawings made use of positive metaphors. The metaphors generated by the students can be subsumed under the categories of “personal characteristics” and “duties”. The most commonly generated metaphors related to personal characteristics of the directors can be grouped under the category of “good people” and the most commonly generated metaphors in relation to their duties can be grouped under the category of “management” for the school director and “informing” for the vice school director.

  17. 76 FR 64364 - Redelegations of Authority to Directors and Deputy Directors of Community Planning and...

    Science.gov (United States)

    2011-10-18

    ..., Director of Technical Assistance and Management, Office of Community Planning and Development, Department... Affordability Strategies (CHAS), Title I of the Cranston-Gonzalez National Affordable Housing Act, Public Law..., chapter 1, subchapter U of the Internal Revenue Code (codified as ] amended at 26 U.S.C. 1391 et seq.); 24...

  18. 4th July 2011 - Russian Deputy Director-General Director of Directorate for Scientific and Technical Complex ROSATOM V. Pershukov in the ATLAS underground experimental area with Adviser T. Kurtyka, ATLAS Technical Coordinator M. Nessi and ATLAS Russian users.

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    4th July 2011 - Russian Deputy Director-General Director of Directorate for Scientific and Technical Complex ROSATOM V. Pershukov in the ATLAS underground experimental area with Adviser T. Kurtyka, ATLAS Technical Coordinator M. Nessi and ATLAS Russian users.

  19. Chemistry and Materials Science Directorate 2005 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Diaz De La Rubia, T; Fluss, M J; Rath, K; Rennie, G; Shang, S; Kitrinos, G

    2006-08-08

    In 1952, we began laboratory operations in the barracks building of the Naval Air Station with approximately 50 employees. Today, the Chemistry and Materials Science (CMS) Directorate is a major organization at the Lawrence Livermore National Laboratory with more than 500 employees who continue to contribute to our evolving national security mission. For more than half a century, the mission of the Laboratory revolved primarily around nuclear deterrence and associated defense technologies. Today, Livermore supports a broad-based national security mission, and our specialized capabilities increasingly support emerging missions in human health and energy security. In the future, CMS will play a significantly expanded role in science and technology at the intersection of national security, energy and environment, and health. Our world-class workforce will provide the science and technology base for radically innovative materials to our programs and sponsors. Our 2005 Annual Report describes how our successes and breakthroughs follow a path set forward by our strategic plan and four organizing research themes, each with key scientific accomplishments by our staff and collaborators. Organized into two major sections-research themes and dynamic teams, this report focuses on achievements arising from earlier investments that address future challenges. The research presented in this annual report gives substantive examples of how we are proceeding in each of these four theme areas and how they are aligned with our national security mission. Research Themes: (1) Materials Properties and Performance under Extreme Conditions--We are developing ultrahard nanocrystalline metals, exploring the properties of nanotubes when exposed to very high temperatures, and engineering stronger materials to meet future needs for materials that can withstand extreme conditions. (2) Chemistry under Extreme Conditions and Chemical Engineering to Support National-Security Programs--Our recent

  20. Chemistry and Materials Science Directorate 2005 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Diaz De La Rubia, T; Fluss, M J; Rath, K; Rennie, G; Shang, S; Kitrinos, G

    2006-08-08

    In 1952, we began laboratory operations in the barracks building of the Naval Air Station with approximately 50 employees. Today, the Chemistry and Materials Science (CMS) Directorate is a major organization at the Lawrence Livermore National Laboratory with more than 500 employees who continue to contribute to our evolving national security mission. For more than half a century, the mission of the Laboratory revolved primarily around nuclear deterrence and associated defense technologies. Today, Livermore supports a broad-based national security mission, and our specialized capabilities increasingly support emerging missions in human health and energy security. In the future, CMS will play a significantly expanded role in science and technology at the intersection of national security, energy and environment, and health. Our world-class workforce will provide the science and technology base for radically innovative materials to our programs and sponsors. Our 2005 Annual Report describes how our successes and breakthroughs follow a path set forward by our strategic plan and four organizing research themes, each with key scientific accomplishments by our staff and collaborators. Organized into two major sections-research themes and dynamic teams, this report focuses on achievements arising from earlier investments that address future challenges. The research presented in this annual report gives substantive examples of how we are proceeding in each of these four theme areas and how they are aligned with our national security mission. Research Themes: (1) Materials Properties and Performance under Extreme Conditions--We are developing ultrahard nanocrystalline metals, exploring the properties of nanotubes when exposed to very high temperatures, and engineering stronger materials to meet future needs for materials that can withstand extreme conditions. (2) Chemistry under Extreme Conditions and Chemical Engineering to Support National-Security Programs--Our recent

  1. 23rd October 2010 - UNESCO Director-General I. Bokova signing the Guest Book with CERN Director for Research and Scientific Computing S. Bertolucci and CERN Director-General R. Heuer.

    CERN Multimedia

    Maximilien Brice

    2010-01-01

    CERN-HI-1010244 37: in the SM18 hall: Ms Jasmina Sopova, Communication Officer J. Sopova; Director, Division of Basic & Engineering Sciences M. Nalecz, Assistant Director-General for the Natural Sciences G. Kalonji; Former CERN Director-General H. Schopper, CERN Head of Education R. Landua; UNESCO Director-General I. Bokova; CERN Adviser M. Bona; CERN Director for Research and Scientific Computing S. Bertolucci and UNESCO Office in Geneva Director Luis M. Tiburcio.

  2. Pump used as a turbine (PAT) with flow control - Part 4: Sizing the new spiral casing; Petites centrales hydrauliques. Pompe fonctionnant en turbine avec reglage du debit (Pat-Francis). 4eme partie: dimensionnement et construction de la bache spirale

    Energy Technology Data Exchange (ETDEWEB)

    Chapallaz, J.-M.

    2007-02-15

    This fourth and final part of a final report for the Swiss Federal Office of Energy (SFOE) discusses the use of a pump equipped with variable guide vanes, similar to a Francis turbine. This fourth part of a four-part article deals with the selection of a pump and describes the general lay-out of the new spiral casing to be adapted for use in the PAT-Francis turbine. The parameters to be taken into account are looked at and calculation examples are presented. Proposals for a simplified construction are examined.

  3. 24 February 2012 - Portuguese Minister for Education and Science N. Crato visiting the LHC superconducting magnet test hall with technology Department Head F. Bordry and signing the guest book with CERN Director-General R. Heuer. The Minister is accompanied by Secretary of State for Science L. Parreira and LIP Director J.M. Gago. A. Henriques(ATLAS), C. Lourenço (CMS) and Adviser R. Voss accompany the delegation throughout.

    CERN Multimedia

    Maximilien Brice

    2012-01-01

    On 24 February Nuno Crato, the Portuguese minister for education and science, left, toured the LHC superconducting-magnet test hall accompanied by Frédérick Bordry, CERN’s technology department head. He also took the opportunity to visit the underground experimental areas of ATLAS and CMS, and heard about the LHC Computing Grid Project before meeting Portuguese scientists working at CERN.

  4. INTERFIRM COOPERATION AND INFORMATION SHARING THROUGH INTERLOCKING DIRECTORATES

    Directory of Open Access Journals (Sweden)

    Mohammed Belal UDDIN

    2012-01-01

    Full Text Available When firms engage in cooperative efforts, interfirm relations get particular interest to be studied. A direct interlock occurs when an executive or director of one firm sits on the board of another firm, and an indirect interlock occurs when two firms have directors or executives who sit on the board of a third firm. The three commonly used theoretical models such as social network theory, learning theory, and theory of strategic choice are more relevant for the formation and management of interlocking directorates. Uncertainty, resource scarcity, mutual trust, dependency, etc. influence the formation of interlocking directorates. Consequently, interlocking directorates allow sharing of information and overall cooperation between partners through learning, collaboration, networking, and effective relationship, etc. Proper management of interlocking directorates requires communication and collaboration among partners that enhance exchange of knowledge and cooperation.

  5. A Time Study of Scientists & Engineers (S&Es) in the Air Vehicles Directorate

    Science.gov (United States)

    2010-01-01

    A TIME STUDY OF SCIENTISTS & ENGINEERS (S&Es) IN THE AIR VEHICLES DIRECTORATE JoAnn McCabe and Col John Wissler, USAF The Air Vehicles...Defense Acquisition University www.dau.mil Keywords: Time Study of Scientists and Engineers, Air Force Research Laboratory (AFRL) Research, Air...Force Research Laboratory Time Study , How Scientists and Engineers Spend Their Time, Technology-Focused Research Organizations, Value and Non-Value

  6. Strategies for Improving Labor and Equipment Data Acquisition for the Heidelberg Directorate of Engineering and Housing

    Science.gov (United States)

    1991-01-01

    8217, , . ’. Strategies for Improving Labor and Equipment Data Acquisition for the Heidelberg Directorate of Engineering and Housing by Roger Day Wayne... strategies for addressing L&E data acquisition problems at Heidelberg. This report summarizes theD findings and makes specific recommendations. The...major recom- mendation is to pursue pilot testing and implementation of push - button station technology. Together, the hardware and software components of

  7. Efectos del agua ozonizada sobre microorganismos patógenos y alterantes de frutas y hortalizas

    Directory of Open Access Journals (Sweden)

    Laura Frisón

    2013-01-01

    Full Text Available La demanda de productos mínimamente procesados es creciente. Su inocuidad es un tema que preocupa tanto a procesadores, como a agencias de regulación y a consumidores. Las industrias han tenido que buscar métodos más eficaces para evitar el deterioro por microorganismos y mejorar la vida útil. Se considera que una sanitización es segura si el sanitizante logra reducir 5 log (99,999 % eficiencia la concentración de bacterias y 4 log (99,99 % eficiencia la concentración de mohos. Se estudió el efecto del agua ozonizada sobre bacterias patógenas como Bacillus cereus, Pseudomonas sp., Escherichia coli, Sthaphylococcus aureus y Salmonella sp. y sobre hongos fitopatógenos, micotoxigénicos y alterantes de frutas y hortalizas como Aspergillus niger, Penicillium digitatum, Alternaria alternata y Cladosporium cladosporioides.Se realizaron ensayos in vitro mediante el Test de Suspensión a 2 concentraciones de ozono en agua y 4 tiempos de exposición. Se logró determinar el siguiente orden descendente de resistencia en bacterias: B. cereus, Pseudomonas sp., E. coli, S. aureus y Salmonella sp. Se logró determinar el siguiente orden descendente de resistencia en mohos: A. niger, P. digitatum, A. alternata y C. cladosporioides. Se realizaron ensayos sobre hojas de lechuga, que contenían inoculadas las bacterias en estudio, con agua ozonizada ([2 ppm], por 5 minutos y sobre naranjas enteras, que contenían inoculadas conidios de los mohos en estudio, con agua ozonizada ([3 ppm], por 15 minutos. En ninguno de los ensayos se logró reducir más de 3 log la concentración de microorganismos. Teniendo en cuenta que las altas concentraciones de microorganismos inoculados en los ensayos (10E6 - 10E7 células/mL para bacterias y 10E5 - 10E6 conidios/mL para mohos no se encuentran normalmente en estos alimentos frescos, se puede inferir que el ozono podría utilizarse como sanitizante.

  8. Efectos del agua ozonizada sobre microorganismos patógenos y alterantes de frutas y hortalizas

    Directory of Open Access Journals (Sweden)

    Laura Frisón

    2013-06-01

    Full Text Available La demanda de productos mínimamente procesados es creciente. Su inocuidad es un tema que preocupa tanto a procesadores, como a agencias de regulación y a consumidores. Las industrias han tenido que buscar métodos más eficaces para evitar el deterioro por microorganismos y mejorar la vida útil. Se considera que una sanitización es segura si el sanitizante logra reducir 5 log (99,999 % eficiencia la concentración de bacterias y 4 log (99,99 % eficiencia la concentración de mohos. Se estudió el efecto del agua ozonizada sobre bacterias patógenas como Bacillus cereus, Pseudomonas sp., Escherichia coli, Sthaphylococcus aureus y Salmonella sp. y sobre hongos fitopatógenos, micotoxigénicos y alterantes de frutas y hortalizas como Aspergillus niger, Penicillium digitatum, Alternaria alternata y Cladosporium cladosporioides. Se realizaron ensayos in vitro mediante el Test de Suspensión a 2 concentraciones de ozono en agua y 4 tiempos de exposición. Se logró determinar el siguiente orden descendente de resistencia en bacterias: B. cereus, Pseudomonas sp., E. coli, S. aureus y Salmonella sp. Se logró determinar el siguiente orden descendente de resistencia en mohos:A. niger, P. digitatum, A. alternata y C. cladosporioides. Se realizaron ensayos sobre hojas de lechuga, que contenían inoculadas las bacterias en estudio, con agua ozonizada ([2 ppm], por 5 minutos y sobre naranjas enteras, que contenían inoculadas conidios de los mohos en estudio, con agua ozonizada ([3 ppm], por 15 minutos. En ninguno de los ensayos se logró reducir más de 3 log la concentración de microorganismos. Teniendo en cuenta que las altas concentraciones de microorganismos inoculados en los ensayos (106 - 107 células/mL para bacterias y 105 - 106 conidios/mL para mohos no se encuentran normalmente en estos alimentos frescos, se puede inferir que el ozono podría utilizarse como sanitizante.

  9. From Mini to Micro Scale—Feasibility of Raman Spectroscopy as a Process Analytical Tool (PAT

    Directory of Open Access Journals (Sweden)

    Peter Kleinebudde

    2011-10-01

    Full Text Available Background: Active coating is an important unit operation in the pharmaceutical industry. The quality, stability, safety and performance of the final product largely depend on the amount and uniformity of coating applied. Active coating is challenging regarding the total amount of coating and its uniformity. Consequently, there is a strong demand for tools, which are able to monitor and determine the endpoint of a coating operation. In previous work, it was shown that Raman spectroscopy is an appropriate process analytical tool (PAT to monitor an active spray coating process in a pan coater [1]. Using a multivariate model (Partial Least Squares—PLS the Raman spectral data could be correlated with the coated amount of the API diprophylline. While the multivariate model was shown to be valid for the process in a mini scale pan coater (batch size: 3.5 kg cores, the aim of the present work was to prove the robustness of the model by transferring the results to tablets coated in a micro scale pan coater (0.5 kg. Method: Coating experiments were performed in both, a mini scale and a micro scale pan coater. The model drug diprophylline was coated on placebo tablets. The multivariate model, established for the process in the mini scale pan coater, was applied to the Raman measurements of tablets coated in the micro scale coater for six different coating levels. Then, the amount of coating, which was predicted by the model, was compared with reference measurements using UV spectroscopy. Results: For all six coating levels the predicted coating amount was equal to the amounts obtained by UV spectroscopy within the statistical error. Thus, it was possible to predict the total coating amount with an error smaller than 3.6%. The root mean squares of errors for calibration and prediction (root mean square of errors for calibration and prediction—RMSEC and RMSEP were 0.335 mg and 0.392 mg, respectively, which means that the predictive power of the model

  10. 25 CFR 175.4 - Authority of area director.

    Science.gov (United States)

    2010-04-01

    ... General Provisions § 175.4 Authority of area director. The Area Director may delegate authority under this part to the Officer-in-Charge except for the authority to set rates as described in §§ 175.10 through... 25 Indians 1 2010-04-01 2010-04-01 false Authority of area director. 175.4 Section 175.4 Indians...

  11. Council appoints CERN’s next Director General

    CERN Multimedia

    Maximilien Brice

    2007-01-01

    On 14 December 2007, CERN Council appointed Professor Rolf-Dieter Heuer to succeed Dr Robert Aymar as CERN Director General. Professor Heuer will serve a five-year term, taking office on 1 January 2009. From Left to right: Dr Robert Aymar, current CERN Director General, Professor Torsten Åkesson, President of CERN Council, and Professor Rolf-Dieter Heuer, CERN's next Director General.

  12. NASA Astrophysics Technology Needs

    Science.gov (United States)

    Stahl, H. Philip

    2012-01-01

    July 2010, NASA Office of Chief Technologist (OCT) initiated an activity to create and maintain a NASA integrated roadmap for 15 key technology areas which recommend an overall technology investment strategy and prioritize NASA?s technology programs to meet NASA?s strategic goals. Science Instruments, Observatories and Sensor Systems(SIOSS) roadmap addresses technology needs to achieve NASA?s highest priority objectives -- not only for the Science Mission Directorate (SMD), but for all of NASA.

  13. Information Technology Initiative (Videorecording),

    Science.gov (United States)

    Physical description: 1 VHS video; col.; sd.; mono.; standard playback sp.; 35:40 mins.; 1/2 in. In this video, Dr. Kurt Fisher, Deputy Director for Information Technology , introduces the Corporate Information Management (CIM) program and explains the following major technical initiatives: reuse/repositories; I-case; data administration; information technology architecture; software process improvement; standards.

  14. Los directores aprendiendo de sus maestros

    OpenAIRE

    Manuel Ortega Muñoz

    2016-01-01

    El presente artículo de investigación está enmarcado dentro de la línea de indagación Aprendizaje para la Gestión y versa sobre los principales aprendizajes que han adquirido los directivos de educación básica del estado de Durango, México, para el mejor ejercicio de su función. Desde un estudio de narrativa, se recopilaron historias de 16 directores de educación primaria estatal pertenecientes a la zona escolar 24 del sector educativo no. 1 de la Secretaría de Educación Pública. El análisis ...

  15. 16th September 2011 - Permanent Representative of Israel to the United Nations Office Ambassador A.Leshno-Yaar signing the Agreement concerning the Granting of the Status of Associate Membership as the Pre-stage to Membership at CERN with CERN Director-General R. Heuer.

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    Standing from left to right: ATLAS Collaboration G. Mikenberg, Israel Delegate to CERN Council E. Rabinovici, CERN Director-General R. Heuer, Director for Administration and General Infrastructure S. Lettow, Ambassador to the UN A. Leshno-Yaar, CERN Legal COunsel E. Groniger-Voss, CERN Council President M. Spiro, Director for Research and Scientific Computing S. Bertolucci, Director for Accelerators and Technology S. Myers and Head of International Relations, F. Pauss.

  16. 2004 Physics and Advanced Technologies In the News

    Energy Technology Data Exchange (ETDEWEB)

    Hazi, A

    2005-11-01

    Several outstanding research activities in the Physics and Advanced Technology Directorate in 2004 were featured in ''Science & Technology Review'', the monthly publication of the Lawrence Livermore National Laboratory. Reprints of those articles accompany this report. Here we summarize other science and technology highlights, as well as the awards and recognition received by members of the Directorate in 2004.

  17. The Roles and Functions of Medical Directors in Nursing Homes.

    Science.gov (United States)

    Nanda, Aman

    2015-03-03

    The medical director is an important member of the healthcare team in a nursing home, and is responsible for overall coordination of care and for implementation of policies related to care of the residents in a nursing home. The residents in nursing homes are frail, medically complex, and have multiple disabilities. The medical director has an important leadership role in assisting nursing home administration in providing quality care that is consistent with current standards of care. This article provides an overview of roles and functions of the medical director, and suggests ways the medical director can be instrumental in achieving excellent care in today's nursing facilities.

  18. 47 CFR 54.703 - The Administrator's Board of Directors.

    Science.gov (United States)

    2010-10-01

    ... billion or less; (3) One director shall represent commercial mobile radio service (CMRS) providers; (4... professional and biographical information about the nominee, to the Chairman of the Federal...

  19. The 6th Meeting of CAS Board of Executive Directors

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ The 6th meeting of the board of executive directors of China Association for Standardization (CAS) (the 2nd chairman meeting in 2005) was held in Beijing on January 19th, 2006. The attendees were Mr. Li Zhonghai, President of CAS, who presided over the meeting, Ms. Li Rui and Mr. Li Chuntian, Advisers of CAS, Sun Xiaokang and Shi Baoquan, Vice Directors of SAC (Standardization Administration of China), Jiao Yunqi, President of CNIS (China National Institute of Standardization), Zhang Jianquan, Director of SPC (the Standards Press of China), over 20executive directors and some CAS officers.

  20. Anotaciones sobre el clima de los bosques de guandal del delta del río patía

    OpenAIRE

    Del Valle Arango Jorge Ignacio

    2012-01-01

    Este ensayo intenta describir el clima del litoral Pacifico sur colombiano de una manera más precisa y empleando un cúmulo mayor de registros que en otros trabajos anteriores. Con esta base se realiza una clasificación bioclimática para los bosques de guandal del delta del río Patía. En cuanto a la lluvia se hace énfasis no sólo en los promedios mensuales y anuales sino en su oscilación y desviaciones estándar con el fin de evidenciar lo variable de tan importante factor climático. Finalmente...

  1. Danos mecânicos associados a patógenos e desempenho de sementes de milho

    OpenAIRE

    Cicero Carlos Moure; Silva Walter Rodrigues da

    2003-01-01

    As danificações provocadas nas sementes por operações mecanizadas realizadas durante a produção podem atuar negativamente na qualidade do material obtido. Essa redução qualitativa, segundo a literatura específica, pode ser agravada quando a injúria interage com microrganismos presentes na superfície das sementes ou no solo, por ocasião da semeadura. Dessa forma, o presente trabalho, realizando inoculações de patógenos e injúrias nas regiões da calota endospermática, do ápice do escutelo e da ...

  2. Anotaciones sobre el clima de los bosques de guandal del delta del río patía

    OpenAIRE

    Del Valle Arango Jorge Ignacio

    2012-01-01

    Este ensayo intenta describir el clima del litoral Pacifico sur colombiano de una manera más precisa y empleando un cúmulo mayor de registros que en otros trabajos anteriores. Con esta base se realiza una clasificación bioclimática para los bosques de guandal del delta del río Patía. En cuanto a la lluvia se hace énfasis no sólo en los promedios mensuales y anuales sino en su oscilación y desviaciones estándar con el fin de evidenciar lo variable de tan importante factor climático. Finalmente...

  3. 75 FR 69049 - Expansion and Extension of the Green Technology Pilot Program

    Science.gov (United States)

    2010-11-10

    ... Pilot Program for Green Technologies Including Greenhouse Gas Reduction, 74 FR 64666 (December 8, 2009... Pilot Program, 75 FR 28554 (May 10, 2010), 1355 Off. Gaz. Pat. Office 188 (June 15, 2010). The Green... Patent and Trademark Office Expansion and Extension of the Green Technology Pilot Program AGENCY:...

  4. 75 FR 28554 - Elimination of Classification Requirement in the Green Technology Pilot Program

    Science.gov (United States)

    2010-05-21

    ... Greenhouse Gas ] Reduction, 74 FR 64666 (December 8, 2009), 1349 Off. Gaz. Pat. Office 362 (December 29, 2009... Technology Pilot Program AGENCY: United States Patent and Trademark Office, Commerce. ACTION: Notice. SUMMARY: The United States Patent and Trademark Office (USPTO) implemented the Green Technology Pilot...

  5. Strategic funding priorities in the pharmaceutical sciences allied to Quality by Design (QbD) and Process Analytical Technology (PAT)

    DEFF Research Database (Denmark)

    Aksu, Buket; De Beer, Thomas; Folestad, Staffan

    2012-01-01

    Substantial changes in Pharmaceutical R&D strategy are required to address existing issues of low productivity, imminent patent expirations and pressures on pricing. Moves towards personalized healthcare and increasing diversity in the nature of portfolios including the rise of biopharmaceuticals......, include product design and development for personalized healthcare, continuous-processing in pharmaceutical product manufacture, quantitative quality risk assessment for pharmaceutical development including life cycle management and the downstream processing of biopharmaceutical products. Plans are being...

  6. Professor Andrzej Budzanowski, Director General, Henryk Niewodniczanski Institute of Nuclear Physics (HNINP) Poland. Dr. Grzegorz Polok, Deputy Director

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    Andrzej Budzanowski, Director-General of the Cracow Institute of Nuclear Physics (HNINP) and Lyn Evans, LHC Project Leader, signing the collaboration agreement. In the background, from leftto right : Grzegorz Polok, Deputy Director-General of the Cracow Institute of Nuclear Physics, Blazej Skoczen, in charge of the LHC cryomagnet interconnections, Claude Détraz, Director for Fixed Target and Future Programmes, Alain Poncet, AT/CRI Group Leader.

  7. Safety evaluation of the phosphinothricin acetyltransferase proteins encoded by the pat and bar sequences that confer tolerance to glufosinate-ammonium herbicide in transgenic plants.

    Science.gov (United States)

    Hérouet, Corinne; Esdaile, David J; Mallyon, Bryan A; Debruyne, Eric; Schulz, Arno; Currier, Thomas; Hendrickx, Koen; van der Klis, Robert-Jan; Rouan, Dominique

    2005-03-01

    Transgenic plant varieties, which are tolerant to glufosinate-ammonium, were developed. The herbicide tolerance is based upon the presence of either the bar or the pat gene, which encode for two homologous phosphinothricin acetyltransferases (PAT), in the plant genome. Based on both a review of published literature and experimental studies, the safety assessment reviews the first step of a two-step-approach for the evaluation of the safety of the proteins expressed in plants. It can be used to support the safety of food or feed products derived from any crop that contains and expresses these PAT proteins. The safety evaluation supports the conclusion that the genes and the donor microorganisms (Streptomyces) are innocuous. The PAT enzymes are highly specific and do not possess the characteristics associated with food toxins or allergens, i.e., they have no sequence homology with any known allergens or toxins, they have no N-glycosylation sites, they are rapidly degraded in gastric and intestinal fluids, and they are devoid of adverse effects in mice after intravenous administration at a high dose level. In conclusion, there is a reasonable certainty of no harm resulting from the inclusion of the PAT proteins in human food or in animal feed.

  8. 77 FR 72904 - In the Matter of HealthSport, Inc., Home Director, Inc., Home Theater Products International, Inc...

    Science.gov (United States)

    2012-12-06

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION In the Matter of HealthSport, Inc., Home Director, Inc., Home Theater Products International, Inc., House of Taylor Jewelry, Inc. (n/ k/a Global Jewelry Concepts, Inc.), and Huifeng Bio-Pharmaceutical Technology, Inc.; Order of Suspension...

  9. Susceptibilidad a antimicrobianos de patógenos respiratorios en niños provenientes de la comunidad

    Directory of Open Access Journals (Sweden)

    José M Guevara

    2004-03-01

    Full Text Available Objetivo: Determinar la resistencia de los patógenos respiratorios a diferentes antimicrobianos. Material y Métodos: Entre abril y noviembre de 2002 se estudió 177 pacientes que asistieron al consultorio externo de otorrinolaringología del Hospital Nacional Docente Madre-Niño San Bartolomé. Resultados: Streptococcus pneumoniae fue la bacteria patógena más aislada (57,2%, luego Moraxella catarrhalis (42,7%, Staphylococcus aureus (18,6% y en pequeña cantidad Haemophilus influenzae (3,4% y Streptococcus pyogenes (0,7%. Streptococcus pneumoniae presentó 31,3% de resistencia a la penicilina. El 96,7% de Moraxella catarrhalis fueron productoras de betalactamasa y 7,4% de los Staphylococcus aureus fueron resistentes a la oxacilina. Conclusión: Streptococcus pneumoniae es el principal agente causal de los procesos infecciosos altos en niños y su resistencia a la penicilina aumentó a 31,3%.

  10. Transmisión de protozoarios patógenos a través del agua para consumo humano.

    Directory of Open Access Journals (Sweden)

    Yezid Solarte

    2009-11-01

    Full Text Available Los protozoarios patógenos Cryptosporidium parvum y Giardia sp. han demostrado su infectividad e impacto negativo en la salud de miles de personas tanto en naciones industrializadas como en los países en desarrollo. La mayoría de los protozoarios por presentar una forma resistente a las condiciones ambientales, les permite la supervivencia a los tratamientos físico-químicos del agua para consumo humano. De igual forma, la aparición de nuevos patógenos demuestra la necesidad de desarrollar nuevos indicadores de calidad microbiológica que permitan ofrecer productos verdaderamente seguros en el agua para uso humano. El presente artículo es una revisión de literatura que señala el impacto de este riesgo microbiológico, asociado fundamentalmente con el consumo de aguas cuyos indicadores clásicos de contaminación microbiológica (coliformes fecales y Escherichia coli en casi todos los casos cumplen con las normas vigentes.

  11. Transmisión de protozoarios patógenos a través del agua para consumo humano

    Directory of Open Access Journals (Sweden)

    Yezid Solarte

    2006-03-01

    Full Text Available Los protozoarios patógenos Cryptosporidium parvum y Giardia sp. han demostrado su infectividad e impacto negativo en la salud de miles de personas tanto en naciones industrializadas como en los países en desarrollo. La mayoría de los protozoarios por presentar una forma resistente a las condiciones ambientales, les permite la supervivencia a los tratamientos físico-químicos del agua para consumo humano. De igual forma, la aparición de nuevos patógenos demuestra la necesidad de desarrollar nuevos indicadores de calidad microbiológica que permitan ofrecer productos verdaderamente seguros en el agua para uso humano. El presente artículo es una revisión de literatura que señala el impacto de este riesgo microbiológico, asociado fundamentalmente con el consumo de aguas cuyos indicadores clásicos de contaminación microbiológica (coliformes fecales y Escherichia coli en casi todos los casos cumplen con las normas vigentes.

  12. Adaptabilidade, estabilidade e resistência a patógenos em genótipos de feijoeiro

    Directory of Open Access Journals (Sweden)

    Cleber Vinicius Giaretta Azevedo

    2015-10-01

    Full Text Available Resumo:O objetivo deste trabalho foi avaliar a resistência de genótipos de feijoeiro aos principais patógenos da cultura, bem como a adaptabilidade e a estabilidade de produção de grãos desses genótipos. Avaliaram-se 26 genótipos de feijoeiro quanto à resistência a Colletotrichum lindemuthianum, Fusarium oxysporum f. sp. phaseolie Xanthomonas axonopodis pv. phaseoli, por meio de inoculação, em laboratório, e em 19 ensaios de valor de cultivo e uso (VCU, em diferentes locais do Estado de São Paulo, nas safras das "águas", "seca" e "inverno", durante os anos agrícolas 2011, 2012 e 2013. Dezoito genótipos foram considerados resistentes: sete deles a C. lindemuthianum, sete a F. oxysporumf. sp. phaseolie quatro a X. axonopodispv. phaseoli. A reação de resistência aos patógenos está associada à estabilidade dos genótipos. Por meio das análises GGE biplot, foi possível identificar genótipos com adaptabilidade e estabilidade superiores às das testemunhas, nos dois grupos de tegumento avaliados, em todas as épocas de semeadura.

  13. Mass-spectrometry analysis of histone post-translational modifications in pathology tissue using the PAT-H-MS approach

    Directory of Open Access Journals (Sweden)

    Roberta Noberini

    2016-06-01

    Full Text Available Aberrant histone post-translational modifications (hPTMs have been implicated with various pathologies, including cancer, and may represent useful epigenetic biomarkers. The data described here provide a mass spectrometry-based quantitative analysis of hPTMs from formalin-fixed paraffin-embedded (FFPE tissues, from which histones were extracted through the recently developed PAT-H-MS method. First, we analyzed FFPE samples from mouse spleen and liver or human breast cancer up to six years old, together with their corresponding fresh frozen tissue. We then combined the PAT-H-MS approach with a histone-focused version of the super-SILAC strategy-using a mix of histones from four breast cancer cell lines as a spike-in standard- to accurately quantify hPTMs from breast cancer specimens belonging to different subtypes. The data, which are associated with a recent publication (Pathology tissue-quantitative mass spectrometry analysis to profile histone post-translational modification patterns in patient samples (Noberini, 2015 [1], are deposited at the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier http://www.ebi.ac.uk/pride/archive/projects/PXD002669.

  14. Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA.

    Science.gov (United States)

    Albesa-Jové, David; Svetlíková, Zuzana; Tersa, Montse; Sancho-Vaello, Enea; Carreras-González, Ana; Bonnet, Pascal; Arrasate, Pedro; Eguskiza, Ander; Angala, Shiva K; Cifuente, Javier O; Korduláková, Jana; Jackson, Mary; Mikušová, Katarína; Guerin, Marcelo E

    2016-03-11

    The biosynthesis of phospholipids and glycolipids are critical pathways for virtually all cell membranes. PatA is an essential membrane associated acyltransferase involved in the biosynthesis of mycobacterial phosphatidyl-myo-inositol mannosides (PIMs). The enzyme transfers a palmitoyl moiety from palmitoyl-CoA to the 6-position of the mannose ring linked to 2-position of inositol in PIM1/PIM2. We report here the crystal structures of PatA from Mycobacterium smegmatis in the presence of its naturally occurring acyl donor palmitate and a nonhydrolyzable palmitoyl-CoA analog. The structures reveal an α/β architecture, with the acyl chain deeply buried into a hydrophobic pocket that runs perpendicular to a long groove where the active site is located. Enzyme catalysis is mediated by an unprecedented charge relay system, which markedly diverges from the canonical HX4D motif. Our studies establish the mechanistic basis of substrate/membrane recognition and catalysis for an important family of acyltransferases, providing exciting possibilities for inhibitor design.

  15. Veterinary Technician Program Director Leadership Style and Program Success

    Science.gov (United States)

    Renda-Francis, Lori A.

    2012-01-01

    Program directors of American Veterinary Medical Association (AVMA) accredited veterinary technician programs may have little or no training in leadership. The need for program directors of AVMA-accredited veterinary technician programs to understand how leadership traits may have an impact on student success is often overlooked. The purpose of…

  16. The Qualifications and Educational Needs of Industrial Training Directors.

    Science.gov (United States)

    Gossage, Loyce Clyde

    This study investigated the hypothesis that industrial training directors are required to perform educational duties for which they lack appropriate, organized instruction. Questionnaires were sent to 778 principal training directors, of whom 238 responded. Data were obtained on sizes of firms represented, numbers of trainees served, employment…

  17. 18 CFR 701.77 - Director-duties and responsibilities.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Director-duties and... ORGANIZATION Headquarters Organization § 701.77 Director—duties and responsibilities. The Director shall serve... their authorities; and facilitate the work of the Council and the Chairman. His duties...

  18. 19 CFR 146.2 - Port director as Board representative.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Port director as Board representative. 146.2 Section 146.2 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) FOREIGN TRADE ZONES General Provisions § 146.2 Port director as...

  19. Veterinary Technician Program Director Leadership Style and Program Success

    Science.gov (United States)

    Renda-Francis, Lori A.

    2012-01-01

    Program directors of American Veterinary Medical Association (AVMA) accredited veterinary technician programs may have little or no training in leadership. The need for program directors of AVMA-accredited veterinary technician programs to understand how leadership traits may have an impact on student success is often overlooked. The purpose of…

  20. Creating the Vision: Directors Don't Do It Alone.

    Science.gov (United States)

    Carlisle, Barbara; Drapeau, Don

    1997-01-01

    Argues that good directors are not as autocratic and individualistic as they are often portrayed. Suggests that theater is much more of an ensemble effort. States that good theater grows out of the performers' desire to reach the audience. Articulates guidelines for the teacher or theater director who wishes to change "I" to "We." (PA)

  1. 42 CFR 493.1405 - Standard; Laboratory director qualifications.

    Science.gov (United States)

    2010-10-01

    ... Testing Laboratories Performing Moderate Complexity Testing § 493.1405 Standard; Laboratory director... performance of moderate complexity tests and must be eligible to be an operator of a laboratory within the... medical education credit hours in laboratory practice commensurate with the director responsibilities...

  2. The Managerial Roles of Academic Library Directors: The Mintzberg Model.

    Science.gov (United States)

    Moskowitz, Michael Ann

    1986-01-01

    A study based on a model developed by Henry Mintzberg examined the internal and external managerial roles of 126 New England college and university library directors. Survey results indicate that the 97 responding directors were primarily involved with internal managerial roles and work contacts. (CDD)

  3. 12 CFR 7.2002 - Director or attorney as proxy.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Director or attorney as proxy. 7.2002 Section 7... OPERATIONS Corporate Practices § 7.2002 Director or attorney as proxy. Any person or group of persons, except the bank's officers, clerks, tellers, or bookkeepers, may be designated to act as proxy. The...

  4. 12 CFR 905.10 - Board of Directors.

    Science.gov (United States)

    2010-01-01

    ... Directors—(1) General. The Bank Act vests management of the Finance Board in a five-member Board of... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Board of Directors. 905.10 Section 905.10 Banks... demonstrated commitment to providing specialized housing credit and at least one appointed director must have...

  5. Food Recall Attitudes and Behaviors of School Nutrition Directors

    Science.gov (United States)

    Grisamore, Amber; Roberts, Kevin R.

    2014-01-01

    Purpose/Objectives: The purpose of this study was to explore school nutrition directors' attitudes and behaviors about food recalls. Specific objectives included: 1) Determine current food recall attitudes and the relationship between demographics and these attitudes; 2) Determine current practices of school nutrition directors related to…

  6. 27 CFR 555.76 - Action by regional director (compliance).

    Science.gov (United States)

    2010-04-01

    ... Permit Proceedings § 555.76 Action by regional director (compliance). (a) Initial application proceedings... license or permit but before actions are completed under this subpart, the regional director (compliance... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Action by...

  7. Plan director de seguridad de la información

    OpenAIRE

    Larrahondo Nuñez, Alexander

    2013-01-01

    Elaboración de un plan director de seguridad de la información para una empresa del sector financiero. Elaboració d'un pla director de seguretat de la informació per a una empresa del sector financer. Master thesis for the Computer science program on Computer security.

  8. Rolf-Dieter Heuer is CERN's next Director General

    CERN Multimedia

    2007-01-01

    The CERN Council has appointed Rolf-Dieter Heuer to succedd Robert Aymar as CENR's Director General, starting 1st january 2009; Since 2004, Heuer has been the research director for particle and astroparticle at Germany's DESY laboratory in Hambourg. (1/2 page)

  9. The Role of Programme Directors as Academic Leaders

    Science.gov (United States)

    Milburn, Peter C.

    2010-01-01

    This exploratory study investigates the academic leadership roles and responsibilities performed by programme directors in higher education (also known as programme leaders or course leaders). It will be argued there has been a lack of recognition and research into the leadership role for programme directors, attention instead focusing on…

  10. Professor Wang Jie Met with NSF Assistant Director

    Institute of Scientific and Technical Information of China (English)

    Chen Huai

    2008-01-01

    @@ Prof.Wang Jie,NSFC Vice President,cordially met with Dr.David Lightfoot,Assistant Director of USA National Science Foundation (NSF) responsible for the Directorate for Social,Behavioral and Economic Sciences,on April 21,2008.

  11. Los directores aprendiendo de sus maestros

    Directory of Open Access Journals (Sweden)

    Manuel Ortega Muñoz

    2016-07-01

    Full Text Available El presente artículo de investigación está enmarcado dentro de la línea de indagación Aprendizaje para la Gestión y versa sobre los principales aprendizajes que han adquirido los directivos de educación básica del estado de Durango, México, para el mejor ejercicio de su función. Desde un estudio de narrativa, se recopilaron historias de 16 directores de educación primaria estatal pertenecientes a la zona escolar 24 del sector educativo no. 1 de la Secretaría de Educación Pública. El análisis de los datos se llevó a cabo mediante la herramienta de análisis de información cualitativa Atlas ti versión 7.5. Los hallazgos de la investigación muestran que los principales aprendizajes que los directivos de educación básica del estado de Durango, México han adquirido de sus maestros para el mejor ejercicio de su función son dos: a el trabajo en equipo, del cual se desprenden componentes como una eficaz y eficiente organización del trabajo, el trabajar siempre en colaboración y tener la mejor de las actitudes para trabajar; y b el liderazgo compartido, aspecto en que se perciben elementos como el óptimo manejo y resolución de conflictos, el liderazgo y la toma de decisiones en conjunto por parte del colectivo escolar. Abstract This research paper, framed within the line of inquiry Learning Management, deals with the main lessons that have acquired the management of basic education in the state of Durango, Mexico, for the best performance of their duties, from a study of narrative histories of 16 directors of state primary education outside the school zone 24 the education sector 1 of the Ministry of Education. The data analysis was performed using the computer statistical package you Atlas ti version 7.5. The research findings show that there are two main lessons that have acquired the management of basic education in the state of Durango, Mexico from their teachers for the better performance of their function: a teamwork

  12. Human induced discharge diversion in a tropical delta and its environmental implications: The Patía River, Colombia

    Science.gov (United States)

    Restrepo, Juan D.; Kettner, Albert

    2012-03-01

    SummaryThe Patía River, the number one in terms of sediment yield ˜1500 t km-2 yr-1 draining the western South America, has the most extensive and well developed delta on the Pacific coast, measuring 1700 km2. During the Holocene, nature forced the Patía delta to the south; however, a major water diversion, starting in 1972, diverted the Patía flow to the Sanguianga River, the latter, a small stream draining internal lakes from the Pacific lowlands. This human induced discharge diversion shifted the active delta plain back to the north and changed the northern estuarine system into an active delta plain. Overall, major environmental consequences of this discharge diversion in terms of morphological changes along the delta coast and distributary channels, are evidenced by: (1) coastal retreat along the abandoned delta lobe; 63% of the southern shoreline is retreating at maximum rates of 7 m yr-1, with a corresponding coastal land loss of 106 m yr-1; (2) transgressive barrier islands with exposed peat soils in the surf zone; (3) abandonment of former active distributaries in the southern delta plain with associated closing of inlets and formation of ebb tidal deltas; (4) breaching events on barrier islands; and (5) distributary channel accretion in the northern delta plain by morphological processes such as sedimentation (also in crevasses), overbank flow, increasing width of levees, interdistributary channel fill, and colonization of pioneer mangrove. The Sanguianga Mangrove National Park (SMNP), the largest mangrove reserve in Colombia, measuring 800 km2, lies in this former estuary, where major hydrologic and sedimentation changes are occurring. Observed environmental changes in the SMNP, include (1) seaward advance of the sub-aqueous delta front at the Sanquianga inlet evidenced by an increase in tidal flat area from 5.4 Mm2 in 1986 to 14 Mm2 in 2001; (2) freshening conditions in the Sanguianga distributary channel, a hydrologic change that has shifted the

  13. Auditor’s Risk Assessment of Independent Directors in Nigeria

    Directory of Open Access Journals (Sweden)

    Salau Abdulmalik

    2017-01-01

    Full Text Available The objective of this study is to investigate the external auditor’s risk assessment of independent directors in Nigeria. The study utilized data from 94 non-financial listed companies on the Nigerian Stock Exchange for the periods 2008-2013. The study used cross-sectional time-series feasible generalized least square regression, which account for heteroscedasticity and autocorrelation to test the influence independent non-executive director on auditor pricing decision in Nigeria. Our result indicates that the proportion of independent non-executive director has a positive relationship with audit fees, suggesting that this class of directors is priced high by the Nigerian auditors. These findings have both policy and practical implication on corporate governance. For instance, future regulatory reforms could consider collaborative board model instead of the insistence on more independent director presence in the boardroom.

  14. JSC Director's Discretionary Fund 1992 Annual Report

    Science.gov (United States)

    Jenkins, Lyle (Compiler)

    1993-01-01

    Annual report of the Johnson Space Center Director's Discretionary Fund documenting effective use of resources. The $1,694,000 funding for FY92 was distributed among 27 projects. The projects are an overall aid to the NASA mission, as well as providing development opportunities for the science and engineering staff with eventual spinoff to commercial uses. Projects described include space-based medical research such as the use of stable isotopes of deuterium and oxygen to measure crew energy use and techniques for noninvasive motion sickness medication. Recycling essentials for space crew support is conducted in the Regenerative Life Support and the Hybrid Regenerative Water Recovery test beds. Two-phase fluid flow simulated under low-gravity conditions, hypervelocity particle impact on open mesh bumpers, and microcalorimetry to measure the long-term hydrazine/material compatibility were investigated. A patent application was made on a shape-memory-alloy release nut. Computer estimate of crew accommodations for advanced concepts was demonstrated. Training techniques were evaluated using multimedia and virtual environment. Upgrades of an electronic still camera provide high resolution images from orbit are presented.

  15. Parsing apical oxalate exchange in Caco-2BBe1 monolayers: siRNA knockdown of SLC26A6 reveals the role and properties of PAT-1.

    Science.gov (United States)

    Freel, Robert W; Morozumi, Makoto; Hatch, Marguerite

    2009-11-01

    The purpose of this investigation was to quantitate the contribution of the anion exchanger PAT-1 (putative anion transporter-1), encoded by SLC26A6, to oxalate transport in a model intestinal epithelium and to discern some characteristics of this exchanger expressed in its native environment. Control (Con) Caco-2 BBe1 monolayers, 6-8 days postseeding, were compared with those transfected with a small interfering RNA targeted to SLC26A6 (A6KD). Radiotracer and Ussing chamber techniques were used to determine the transepithelial unidirectional fluxes of Ox(2-), Cl(-), and SO(4)(2-) whereas fluorometric/BCECF measurements of intracellular pH were used to assess HCO(3)(-) exchange. PAT-1 was functionally targeted to the apical membrane, and SLC26A6 knockdown reduced PAT-1 protein (>60%) and mRNA (>75%) expression in A6KD. No net flux of Ox(2-), Cl(-), or SO(4)(2-) was detected in Con or A6KD monolayers, yet the unidirectional fluxes in A6KD were reduced 50, 35, and 15%, respectively. Cl(-)-dependent HCO(3)(-) efflux from A6KD was reduced 50% compared with Con. The difference between Con and A6KD properties represents that mediated solely by PAT-1, and by this approach we found that PAT-1-mediated oxalate influx and efflux are inhibited equally by mucosal DIDS (EC(50) approximately 5 microM) and that mucosal Cl(-) inhibits oxalate uptake with an EC(50) PAT-1-mediated oxalate exchange suggests that vectorial oxalate transport observed in vivo is principally dependent on the magnitude and direction of counterion gradients.

  16. 3 October 2013 - Ukrainian Vice Prime Minister Ukraine K. I. Gryschenko welcomed by CERN Director-General R. Heuer who introduces Head of International Relations R. Voss; Head of Technology Department F. Bordry; Deputy Head of International Relations E. Tsesmelis; Deputy Legal Counsel M. Wilbers; Adviser for Ukraine T. Kurtyka; Signing of the Agreement between Ukraine and CERN concerning the granting of the status of Associate Member at CERN; in the LHC tunnel at Point 5 and visiting CMS experimental area with CERN Team Leader A. Petrilli.

    CERN Document Server

    Anna Pantelia

    2013-01-01

    3 October 2013 - Ukrainian Vice Prime Minister Ukraine K. I. Gryschenko welcomed by CERN Director-General R. Heuer who introduces Head of International Relations R. Voss; Head of Technology Department F. Bordry; Deputy Head of International Relations E. Tsesmelis; Deputy Legal Counsel M. Wilbers; Adviser for Ukraine T. Kurtyka; Signing of the Agreement between Ukraine and CERN concerning the granting of the status of Associate Member at CERN; in the LHC tunnel at Point 5 and visiting CMS experimental area with CERN Team Leader A. Petrilli.

  17. Energy and Technology Review

    Energy Technology Data Exchange (ETDEWEB)

    Bookless, W.A.; Quirk, W.J. [eds.

    1994-06-01

    This report discusses: The Clementine satellite, the first US satellite to the Moon in more than two decades, sent back more than 1.5 million images of the lunar surface using cameras designed and calibrated by LLNL. An LLNL-developed laser ranger provided information that will be used to construct a relief map of the Moon`s surface; and Uncertainty and the Federal Role in Science and Technology, Ralph E. Gomory was a recent participate in the Director`s Distinguished Lecturer Series at LLNL. In his lecture, he addressed some of the tensions, conflicts, and possible goals related to federal support for science and technology.

  18. Técnicas moleculares para la detección e identificación de patógenos en alimentos: ventajas y limitaciones

    OpenAIRE

    Carolina Palomino-Camargo; Yuniesky González-Muñoz

    2014-01-01

    Las enfermedades transmitidas por alimentos, ocasionadas por microorganismos patógenos, constituyen un grave problema de salud pública a nivel mundial. Los métodos microbiológicos utilizados comúnmente en la detección de estos patógenos, de origen alimentario, son laboriosos y consume mucho tiempo. Esta situación, aunada a la demanda por resultados inmediatos y a los avances tecnológicos, ha conducido al desarrollo de una amplia gama de métodos rápidos en las últimas décadas. En base a esto, ...

  19. Origen, distribución y caracterización de Vibrios patógenos en humanos en el medio ambiente en Galicia

    OpenAIRE

    Rodríguez Castro, Alba María

    2013-01-01

    V. cholerae y V. parahaemolyticus son las principales especies patógenas del género Vibrio responsables de un importante número de infecciones transmitidas por alimentos de origen marino. Estudios realizados en Galicia han revelado una importante presencia y persistencia de V. parahaemolyticus con características patógenas en el medio marino. Sin embargo, la información disponible actualmente para entender la biología y la epidemiología de este microorganismo es limitada. En...

  20. PAT (2009)—Revisions to the Paddington Alcohol Test for Early Identification of Alcohol Misuse and Brief Advice to Reduce Emergency Department Re-attendance

    Science.gov (United States)

    Touquet, Robin; Brown, Adrian

    2009-01-01

    The Paddington Alcohol Test (PAT) has evolved over 15 years as a clinical tool to facilitate emergency physicians and nurses giving brief advice and the offer of an appointment for brief intervention by an alcohol nurse specialist. Previous work has shown that unscheduled emergency department re-attendance is reduced by ‘making the connection’ between alcohol misuse and resultant problems necessitating emergency care. The revised ‘PAT (2009)’ now includes education on clinical signs of alcohol misuse and advice on when to request a blood alcohol concentration. PMID:19329654

  1. PAT (2009)--revisions to the Paddington Alcohol Test for early identification of alcohol misuse and brief advice to reduce emergency department re-attendance.

    Science.gov (United States)

    Touquet, Robin; Brown, Adrian

    2009-01-01

    The Paddington Alcohol Test (PAT) has evolved over 15 years as a clinical tool to facilitate emergency physicians and nurses giving brief advice and the offer of an appointment for brief intervention by an alcohol nurse specialist. Previous work has shown that unscheduled emergency department re-attendance is reduced by 'making the connection' between alcohol misuse and resultant problems necessitating emergency care. The revised 'PAT (2009)' now includes education on clinical signs of alcohol misuse and advice on when to request a blood alcohol concentration.

  2. The distinct roles of anion transporters Slc26a3 (DRA) and Slc26a6 (PAT-1) in fluid and electrolyte absorption in the murine small intestine.

    Science.gov (United States)

    Xia, Weiliang; Yu, Qin; Riederer, Brigitte; Singh, Anurag Kumar; Engelhardt, Regina; Yeruva, Sunil; Song, Penghong; Tian, De-An; Soleiman, Manoocher; Seidler, Ursula

    2014-08-01

    The mixing of gastric and pancreatic juice subjects the jejunum to unique ionic conditions with high luminal CO2 tension and HCO3 − concentration. We investigated the role of the small intestinal apical anion exchangers PAT-1 (Slc26a6) and DRA (Slc26a3) in basal and CO2/HCO3 −-stimulated jejunal fluid absorption. Single pass perfusion of jejunal segments was performed in anaesthetised wild type (WT) as well as in mice deficient in DRA, PAT-1, Na+/H+ exchanger 3 (NHE3) or NHE2, and in carbonic anhydrase II (CAII). Unbuffered saline (pH 7.4) perfusion of WT jejunum resulted in fluid absorption and acidification of the effluent. DRA-deficient jejunum absorbed less fluid than WT, and acidified the effluent more strongly, consistent with its action as a Cl−/HCO3 − exchanger. PAT-1-deficient jejunum also absorbed less fluid but resulted in less effluent acidification. Switching the luminal solution to a 5 % CO2/HCO3 − buffered solution (pH 7.4), resulted in a decrease in jejunal enterocyte pHi in all genotypes, an increase in luminal surface pH and a strong increase in fluid absorption in a PAT-1- and NHE3- but not DRA-, CAII, or NHE2-dependent fashion. Even in the absence of luminal Cl−, luminal CO2/HCO3 − augmented fluid absorption in WT, CAII, NHE2- or DRA-deficient, but not in PAT-1- or NHE3-deficient mice, indicating the likelihood that PAT-1 serves to import HCO3 − and NHE3 serves to import Na+ under these circumstances. The results suggest that PAT-1 plays an important role in jejunal Na+HCO3 – reabsorption, while DRA absorbs Cl− and exports HCO3 − in a partly CAII-dependent fashion. Both PAT-1 and DRA significantly contribute to intestinal fluid absorption and enterocyte acid/base balance but are activated by different ion gradients.

  3. 12 CFR 917.2 - General authorities and duties of Bank boards of directors.

    Science.gov (United States)

    2010-01-01

    ... MANAGEMENT § 917.2 General authorities and duties of Bank boards of directors. (a) Management of a Bank. The...'s board of directors for that Bank's management is non-delegable. (b) Duties of Bank directors. Each Bank director shall have the duty to: (1) Carry out his or her duties as director in good faith, in...

  4. 75 FR 17037 - Federal Home Loan Bank Directors' Eligibility, Elections, Compensation and Expenses

    Science.gov (United States)

    2010-04-05

    ... to the directors for the time required of them in performing their duties as directors. Payments...-AA34 Federal Home Loan Bank Directors' Eligibility, Elections, Compensation and Expenses AGENCY... proposed rules, which relate to Federal Home Loan Bank (Bank) director elections and director...

  5. 77 FR 59407 - Homeland Security Science and Technology Advisory Committee (HSSTAC)

    Science.gov (United States)

    2012-09-27

    ... Security Science and Technology Advisory Committee (HSSTAC) AGENCY: Science and Technology Directorate, DHS..., 56662-56663 that the Homeland Security Science and Technology Advisory Committee (HSSTAC) would meet on... will be held at the Department of Homeland Security (DHS), Science and Technology Directorate, 1120...

  6. PENGERTIAN ART DIRECTION DAN PERANAN SEORANG ART DIRECTOR DALAM PERIKLANAN

    Directory of Open Access Journals (Sweden)

    Aryo Bimo

    2010-09-01

    Full Text Available Nowadays advertising is a field that is progressing rapidly and is quite popular majors marked by numerous educational institutions both private and the country that opened specialization advertising. One of the positions in the field of advertising that quite popular is Art Director. The skill of art directing is a bit much has been represented in the department of Visual Communication Design or Graphic design. But it is sometimes still confused between the duties and role of an art director and a graphic designer. This article gives a general overview of what is meant by Art Director as well as roles and duties.

  7. Pengertian Art Direction dan Peranan Seorang Art Director dalam Periklanan

    Directory of Open Access Journals (Sweden)

    Aryo Bimo

    2010-10-01

    Full Text Available Nowadays advertising is a field that is progressing rapidly and is quite popular majors marked by numerous educational institutions both private and the country that opened specialization advertising. One of the positions in the field of advertising that quite popular is Art Director. The skill of art directing is a bit much has been represented in the department of Visual Communication Design or Graphic design. But it is sometimes still confused between the duties and role of an art director and a graphic designer. This article gives a general overview of what is meant by Art Director as well as roles and duties.  

  8. Board Directors' Selection Process Following a Gender Quota

    DEFF Research Database (Denmark)

    Sigurjonsson, Olaf; Arnardottir, Audur Arna

    The 2008 financial crisis in Iceland was triggered by poor governance of three of the country’s major banks and resulted in new corporate governance regulations including a 40% gender quota for the boards of all state-owned enterprises, publicly traded enterprises, and public and private limited......-quota selection of new board directors as well as the attitudes of board members towards the quota and perceptions of the effect of quota on processes. We incorporate a dual qualitative and quantitative methodology with in-depth interviews with 20 board directors and chairs, and a survey of 260 directors who...

  9. Impacto do Programa Água para Todos (PAT sobre a morbi-mortalidade por diarreia em crianças do Estado da Bahia, Brasil Impacto del Programa Agua para Todos (PAT sobre la morbimortalidad por diarrea en niños del Estado de Bahía, Brasil Impact of the Water for All Program (PAT on childhood morbidity and mortality from diarrhea in the Bahia State, Brazil

    Directory of Open Access Journals (Sweden)

    Davide Rasella

    2013-01-01

    Full Text Available O objetivo do presente estudo foi avaliar o impacto do Programa Água para Todos (PAT, implantado no Estado da Bahia, Brasil, por ampliar a cobertura do saneamento básico em áreas de maior vulnerabilidade. Foram selecionados 224 municípios com informações vitais adequadas. Foi utilizado um desenho de estudo antes-e-depois controlado, efetuando uma análise de regressão multivariada para dados em painel com resposta binomial negativa a efeitos fixos do ano 2005 até 2008. A cobertura do PAT, como variável contínua, esteve associada negativamente (p El objetivo del presente estudio fue evaluar el impacto del Programa Agua para Todos (PAT, implantado en el Estado de Bahía, Brasil, para ampliar la cobertura del saneamiento básico en áreas de mayor vulnerabilidad. Fueron seleccionados 224 municipios con información vital adecuada. Se utilizó un diseño de estudio antes-después controlado, efectuando un análisis de regresión multivariada para los datos en panel con respuesta binomial negativa, a efectos fijos del año 2005 hasta el 2008. La cobertura del PAT, como variable continua, estuvo asociada negativamente (p This study aimed to evaluate the impact of the Water for All Program (PAT, launched in Bahia State, Brazil, with the objective of expanding coverage of the water supply and sanitation in areas with high vulnerability to waterborne diseases. A total of 224 municipalities (counties with adequate vital statistics were selected. A controlled before-and-after study design was used, performing analyses with multivariate negative binomial regression with fixed effects, from 2005 to 2008. PAT coverage - as a continuous variable - was negatively associated (p < 0.01 with the under-five mortality rate. Municipalities with coverage ≥ 10% showed a reduction of 39% (p < 0.05 in mortality from diarrhea, under-five mortality of 14% (p < 0.01, and hospitalizations from diarrhea of 6% (p < 0.05 when compared to municipalities without PAT

  10. 32 CFR Appendix D to Part 45 - State Directors of Veterans Affairs

    Science.gov (United States)

    2010-07-01

    ..., App. D Appendix D to Part 45—State Directors of Veterans Affairs Alabama Director, Department of..., Trenton, NJ 08608. New Mexico Director, Veterans Service Commission, P.O. Box 2324, Santa Fe, NM 87503...

  11. Characterisation of the metabolites of an antibacterial endophyte Botryodiplodia theobromae Pat. of Dracaena draco L. by LC-MS/MS.

    Science.gov (United States)

    Zaher, Ahmed M; Moharram, Ahmad M; Davis, Richard; Panizzi, Peter; Makboul, Makboul A; Calderón, Angela I

    2015-01-01

    Botryodiplodia theobromae Pat. belongs to the endophytic fungi that live within the tissues of medicinal plants and produce bioactive natural products. The endophyte was isolated from the leaves of Dracaena draco L. The LC-MS-based metabolite fingerprinting of the ethyl acetate extract of B. theobromae with antibacterial activity led to the identification of 13 metabolites pertaining to various classes: dipeptides (maculosin and L,L-cyclo(leucylprolyl), alkaloid (norharman), coumarin and isocoumarins (bergapten, meranzin and monocerin), sesquiterpene (dihydrocumambrin A), aldehyde (formyl indanone), fatty alcohol (halaminol A) and fatty acid amide (palmitoleamide, palmitamide, capsi-amide and oleamide). This study reports for the first time, the LC-MS and LC-MS/MS identification of 13 known bioactive metabolites from the antibacterial ethyl acetate extract of B.theobromae isolated from the leaves of D. draco L.

  12. Zīmolvedības ietekme uz patērētāju izvēli

    OpenAIRE

    Kozlovska-Zilvestere, Anete

    2010-01-01

    Bakalaura darba tēma ir „Zīmolvedība un Coca – Cola zīmola ietekme uz patērētāju”. Bakalaura darba mērķis ir salīdzināt Coca – Cola zīmola ietekmi Latvijas Universitātes un Rostokas Universitātes, Vācijā, studentu vidū ar Pepsi zīmola ietekmi; izstrādāt priekšlikumus zīmola veiksmīgākai virzīšanai šajās valstīs, atbilstoši zīmolvedības pamatprincipiem.

  13. Anotaciones sobre el Clima de los Bosques de Guandal del Delta del Río Patía

    Directory of Open Access Journals (Sweden)

    Del Valle Arango Jorge Ignacio

    1994-09-01

    Full Text Available Este ensayo intenta describir el clima del litoral Pacifico sur colombiano de una manera más precisa y empleando un cúmulo mayor de registros que en otros trabajos anteriores. Con esta base se realiza una clasificación bioclimática para los bosques de guandal del delta del río Patía. En cuanto a la lluvia se hace énfasis no sólo en los promedios mensuales y anuales sino en su oscilación y desviaciones estándar con el fin de evidenciar lo variable de tan importante factor climático. Finalmente se elaboran isoyetas para la región las cuales consideramos consistentes con la información disponible.

  14. Aislamiento e identificación de patógenos de la estirpe silvestre del ajo (Allium sativum L.

    Directory of Open Access Journals (Sweden)

    Karina Astorga-Quirós

    2014-02-01

    Full Text Available El cultivo del ajo (Allium sativum L. en Costa Rica se podría convertir en una alternativa rentable para la producción y diversificación de los agricultores de hortalizas. Sin embargo, el tipo de reproducción vegetativa que presenta facilita la transmisión y diseminación de enfermedades, lo que provoca un debilitamiento progresivo de los bulbos. Actualmente, se buscan alternativas de manejo diferentes al control químico, para disminuir el impacto ecológico y ambiental de los patógenos que lo afectan. El control biológico es una de ellas, pero presenta dificultades para el aislamiento y la identificación certera de patógenos asociados a pudriciones que se dan en el suelo. Por lo anterior, el objetivo general de esta investigación consistió en aislar e identificar a nivel de especie cepas de Pseudomonas marginalis, Penicillium sp. y Sclerotium cepivorum a partir de material vegetativo de ajo en campo, para su utilización en futuros trabajos de control biológico de estas enfermedades. La metodología seguida permitió aislar e identificar con un alto porcentaje de certeza a P. marginalis, así como obtener cultivos monospóricos de Penicillium sp. y cultivos puros de S. cepivorum. Las técnicas descritas constituyen la base para futuros trabajos relacionados con las fitopatologías en el cultivo del ajo.

  15. Analytical/experimental methods supporting an error budget''-based design of the PATS/PFMS

    Energy Technology Data Exchange (ETDEWEB)

    Bennett, J.G.; Rhorer, R.L.; Stevens, R.R.

    1992-01-01

    The design of a Precision Automated Turning System (PATS) for use in the Department of Energy weapons complex is being carried out under the umbrella of the Precision Flexible Manufacturing System (PFMS) at the Los Alamos National Laboratory. From the beginning of this project, the design has been based on a finished part error budget'' concept that allows the contribution of the elastic displacements from the PATS machine-base to be included in the machining error and the spindle-to-spindle part transfer error. Thus, a number of different analytical models have been used to perform studies of the displacements of key points when the base is subjected to the loadings that occur during movement of the slides on the way system. Finite Element (FE) models have been used in parameter studies. This model has pointer beams'' at the part-machining position along the spindle centerline and at the spindle-to-spindle part transfer position. These rigid pointers indicate the difference in the actual displacements, as opposed to the assumed displacements (thus, the 'error), at these points caused by the base deformation. For example, one of their uses was to study the effects of the locations and the number of base supports. The maximum relative pointer displacements, when the model is loaded by the way system for 3, 6, 11, and a crippled 11 -point support scheme, were studied. Using this information, a decision was made to depart from the conventional 3-point ( milkstool'') support concept, and support the base at 5-points.

  16. Good Modeling Practice for PAT Applications: Propagation of Input Uncertainty and Sensitivity Analysis

    DEFF Research Database (Denmark)

    Sin, Gürkan; Gernaey, Krist; Eliasson Lantz, Anna

    2009-01-01

    The uncertainty and sensitivity analysis are evaluated for their usefulness as part of the model-building within Process Analytical Technology applications. A mechanistic model describing a batch cultivation of Streptomyces coelicolor for antibiotic production was used as case study. The input...

  17. Dual RNA Processing Roles of Pat1b via Cytoplasmic Lsm1-7 and Nuclear Lsm2-8 Complexes

    Directory of Open Access Journals (Sweden)

    Caroline Vindry

    2017-08-01

    Full Text Available Pat1 RNA-binding proteins, enriched in processing bodies (P bodies, are key players in cytoplasmic 5′ to 3′ mRNA decay, activating decapping of mRNA in complex with the Lsm1-7 heptamer. Using co-immunoprecipitation and immunofluorescence approaches coupled with RNAi, we provide evidence for a nuclear complex of Pat1b with the Lsm2-8 heptamer, which binds to the spliceosomal U6 small nuclear RNA (snRNA. Furthermore, we establish the set of interactions connecting Pat1b/Lsm2-8/U6 snRNA/SART3 and additional U4/U6.U5 tri-small nuclear ribonucleoprotein particle (tri-snRNP components in Cajal bodies, the site of snRNP biogenesis. RNA sequencing following Pat1b depletion revealed the preferential upregulation of mRNAs normally found in P bodies and enriched in 3′ UTR AU-rich elements. Changes in >180 alternative splicing events were also observed, characterized by skipping of regulated exons with weak donor sites. Our data demonstrate the dual role of a decapping enhancer in pre-mRNA processing as well as in mRNA decay via distinct nuclear and cytoplasmic Lsm complexes.

  18. Patērētāju apmierinātība Latvijas tūrisma tirgū

    OpenAIRE

    Ilze Medne

    2012-01-01

    Anotācija Promocijas darba mērķis ir izpētīt tūristu kā patērētāju apmierinātības līmeni ar dažādām tūrisma produkta pazīmēm un tā ietekmi uz tūrista turpmāko patērētājuzvedību Latvijas tūrisma tirgū. Promocijas darbā ir apskatīti patērētāju apmierinātības teorētiskie aspekti, apmierinātības/ neapmierinātības izpausmes patērētājuzvedībā, kā arī svarīgākās klientu apmierinātības novērtēšanas metodes. Ir izveidots jauns tūristu apmierinātības daudzfaktoru modelis tūrisma vietām, ietverot ...

  19. Dr. William C. Harris, Director-General, Science Foundation Ireland

    CERN Multimedia

    Maximilien Brice

    2002-01-01

    Pictured with Robert Eisenstein, former assistant director for mathematical and physical sciences (MPS) at the US National Science Foundation (NSF), who is spending a year at CERN as a member of the ATLAS collaboration.

  20. Why so few Women on Boards of Directors?

    DEFF Research Database (Denmark)

    Smith, Nina; Parrotta, Pierpaolo

    2015-01-01

    hypotheses on female board representation that we denote the female-led hypothesis, the tokenism hypothesis, and the pipeline hypothesis, respectively. We find evidence rejecting the female-led hypothesis. Firms with a female chairperson on the board of directors tend to have significantly fewer other...... nonemployee-elected female board members. We also find clear evidence of a tokenism behavior in Danish companies. The likelihood of enlarging the share of non-employee-elected female board members is significantly smaller if one, two, or more women have sat on the board of directors. Finally, the pipeline......This paper analyzes the determinants of women’s representation on boards of directors based on a panel of all privately owned or listed Danish firms with at least 50 employees observed during the period 1998–2010. We focus on the directors who are not elected by the employees and test three...

  1. CERN stop-over for KEK and Fermilab Directors

    CERN Multimedia

    2001-01-01

    En route for a meeting of the International Committee for Future Accelerators, ICFA, held at Germany's DESY laboratory, the Directors of Japan's KEK laboratory and Fermilab in the United States had a stop-over at CERN last Wednesday 7 February. Dr Hirotaka Sugawara, Director General of Japan's high energy physics laboratory, KEK, visited the Antiproton Decelerator, AD. From left to right, Masaki Hori, member of the ASACUSA collaboration, John Eades, contact person for ASACUSA, Dr Hirotaka Sugawara, Werner Pirkl, the PS Division engineer responsible for the Radio Frequency Quadrupole decelerator in the foreground, and Kurt Hübner, CERN's Director of Accelerators. Dr Michael S. Witherell, Director of the Fermi National Accelerator Laboratory, Fermilab, visited construction sites for the LHC, ATLAS, and CMS. He is seen here with a module of the CMS hadronic calorimeter in building 186.

  2. Llewellyn Smith, Director-General designate of CERN, discusses LHC

    CERN Multimedia

    Sweet, William N

    1992-01-01

    Christopher Llewellyn Smith was nominated by the Committee of Council to be Director General of CERN. He aims to pave the way for the Large Hadron Collider and utilize to the full the Large Electron-Positron machine.

  3. Total Quality Management Implementation Strategy: Directorate of Quality Assurance

    Science.gov (United States)

    1989-05-01

    Directorate of Quality Assurance Total Quality Management Implementation Strategy 6. AUTHOR(S) 7. PERFORMING ORGANIZATION NAME(S) AND ADORESS(ES) 8...that job. DTIC 7: t-I ECTE I SEP29 1989 14. SUBJECT TERMS 15. NUMBER OF PAGES TOM ( Total Quality Management ), Quality Assurance, Continuous Process...Prescribed by ANSI Std Z39-18 29d- 102 DEFENSE LOGISTICS AGENCY DIRECTORATE OF QUALITY ASSURANCE 0 TOTAL QUALITY MANAGEMENT IMPLEMENTATION STRATEGY 0 89 9

  4. Gogos, yoyos and dodos; Company directors and industry performance

    OpenAIRE

    Norburn, David

    1984-01-01

    This research investigates the characteristics of 354 directors of Britain's largest companies. Three sections of independent variables were analysed: those relating to the economic environ; those relating to the domestic environ--family background and educational experiences; those relating to self concept. Directors were categorised according to the economic performance of their industries--GOGOs (industries in growth); YOYOs (industries in turbulence); and DODOs (industries in decline)....

  5. A Tale of Two Melt Rocks: Equilibration and Metal/Sulfide-Silicate Segregation in the L7 Chondrites PAT 91501 and LEW 88663

    Science.gov (United States)

    Harvey, R. P.

    1993-07-01

    Type 7 ordinary chondrites have experienced temperatures near or beyond those necessary for partial melting. Two recently collected Antarctic specimens, PAT91501 (PAT) and LEW88663 (LEW), have been tentatively identified as L7 chondrites based on mineral and oxygen isotope compositions [1,2]. The petrology and mineralogy of these meteorites suggests that they have undergone significant metal/sulfide-silicate segregation, with implications for meteorite parent bodies. PAT consists of an equigranular contact-framework of nearly euhedral olivine grains, with interstitial spaces filled by plagioclase, pyroxenes, and several minor phases. Ortho- and clinopyroxene occur in an exsolution relationship. Olivine and pyroxene are highly equilibrated, varying PAT using the methods of [3] are self-consistent at about 1180 degrees C. In thin section, PAT contains only traces of metal, as tiny isolated blebs in sulfide grains; large (>1 cm) globular sulfide inclusions are seen in hand-sample [1], but are not present in the section examined. LEW was originally classified as an achondrite with olivine and pyroxene compositions similar to those in L chondrites [2]. Metal is absent in LEW, although the specimen is small and heavily rusted, making it impossible to gauge the original metal content. Olivine grains are commonly rounded in shape and seldom in contact with more than a few other grains. LEW olivine and pyroxene are also highly equilibrated. Veins of Ni-bearing metal oxides and sulfides are common. Both low- and high-Ca pyroxene occur as discrete grains, orthopyroxene often poikilitically enclosing olivine. Pyroxene equilibration temperatures for LEW are more variable than those for PAT and consistently lower, with an average around 900 degrees C. The various textural and compositional characteristics of PAT and LEW suggest they have experienced partial melting to varying degrees. Both visually resemble charges from experimental melting of ordinary chondrites [4-6]. The

  6. 技术促进学习转型:重视创新教学和教育的科学测量--访经济合作与发展组织教育技能司司长安德烈亚斯·施莱歇尔%Technology for Transforming Learning:Attaching More Importance on Innovative Teaching and Scientific Educational Measurement of Education-An Interview with Andreas Schleicher, Director for Education and Skills of OECD

    Institute of Scientific and Technical Information of China (English)

    金慧; 刘迪; 宋灵青

    2015-01-01

    Editorial Comment:Andreas Schleicher is Director for Education and Skills, and Special Advisor on Education Policy to the Secretary-General of OECD. As a key member of the OECD Senior Management team, he supports the Secretary-General’s strategy to produce analysis and policy advice that advances economic growth and social progress. He promotes the work of the Directorate for Education and Skills on a global stage and fosters co-operation both within and outside the OECD. In addition to policy and country reviews, the work of the Directorate includes the Programme for International Student Assessment (PISA), the OECD Survey of Adult Skills (PIAAC), the OECD Teaching and Learning International Survey (TALIS), and the development and analysis of benchmarks on the performance of education systems (INES). Before joining the OECD, Mr. Schleicher was Director for Analysis at the International Association for Educational Achievement (IEA). He studied Physics in Germany and received a degree in Mathematics and Statistics in Australia. He is the recipient of numerous honours and awards, including the “Theodor Heuss” prize, awarded in the name of the first president of the Federal Republic of Germany for “exemplary democratic engagement”. He holds an honorary professorship at the University of Heidelberg. On the International conference on ICT in Education hold by UNSECO and MOE of China in Qingdao, he gave a panel on Transforming learning: Mainstream innovative pedagogies. In this interview, he shared with us the measures and plans of OECD and the importance of teachers training on ICT in education. He holds that technology does not shorten the social gap but increase the gap, so we need a strong strategy to reduce or close social gaps. He suggests that governments should make sure that the effectiveness of investment on education for the development of their countries in future.%安德烈亚斯·施莱歇尔(Andreas Schleicher)现任

  7. Creative director as a leader El director como líder creativo

    Directory of Open Access Journals (Sweden)

    Paulo Felipe Quintero

    2011-12-01

    Full Text Available The current organizational dynamic in the world places universities in a relevant role to be performed in the society. Hence, the concept of “creativity” is studied from the hierarchical levels to understand the implications of completing creative processes within an organization. The creativity in the universities require management plans, which demand effort from strategic leaders to materialize and make the mission tangible to all involved actors in the organization; thus, facilitating the achievement of financial quality results, impact on entrepreneurial spirit and optimal labor climate. Subsequently, the creativity could become a strategic topic in the institutional development plans for the directors. This article shows the theoretical construction of the research Creative Abilities of Private Universities Directors in Manizales and the Relation with the Organizational Climate.La dinámica actual de las organizaciones en el mundo, pone a las universidades en unlugar relevante frente al papel que deben desempeñar en la sociedad. En este sentido, seaborda el concepto de “creatividad” tan de moda en el escenario actual, desde los nivelesjerárquicos, con el fin de entender lo que verdaderamente implica llevar a cabo procesoscreativos en una organización. La creatividad en las universidades requiere mucho másque metas en planes de gestión. Exige un esfuerzo de los líderes estratégicos, para quela misión no se quede en el papel y sea tangible para todos los actores involucradosen la empresa, y de esa manera sea el vehículo para lograr resultados de calidad en lofinanciero, impactos en el espíritu empresarial y ambientes de trabajo óptimos, de modoque la creatividad se convierta para los directores en un tema estratégico en los planesde desarrollo institucional para la excelencia en los climas de trabajo. El presente artículoresultó de la construcción teórica del trabajo de investigación

  8. Independent Directors and Stakeholders Protection: A Case of Sime Darby

    Directory of Open Access Journals (Sweden)

    Prashanth Beleya

    2012-04-01

    Full Text Available In today’s ever challenging corporate environment, the unfortunate events of decision making by top management has led major companies to suffer huge losses. This results and mistakes made have given a significant impact to the stake holder’s perception and raise a serious questions on the role of board of directors especially the role of independent directors. In today’s fast evolving business pace with stiff economic conditions, unethical and misjudgment in business decisions are driving the board’s role in corporate governance as an integral element. Hence, corporate governance can be defined as the way listed entities should be operating in accordance with legal framework, rules and regulations that underpin an institution so as to ensure strict compliance with law, sharing and balancing of powers between board of directors and stakeholders. As such, the board with a balance mixture of types of directors, where the independent directors predominate the board’s strategy formulation and implementation in the interest of governance is needed. This paper seeks to bring focus to the importance of the role of independent directors in ensuring that the organization runs its operations in the manner where stakeholders especially shareholders and corporate governance is a virtue.

  9. Center Director's Discretionary Fund 2005 Annual Report

    Science.gov (United States)

    Nurge, Mark; Griffin, Timothy; Arens, Ellen; Calle, Carlos; Quinn, Jacqueline; Wheeler, Raymond; Metzger, Phillip T.; Calle, Luz Marina; Beaver, Justin M.; Williams, Martha; Smith, Trent; Robertso, Luke; Clayton, LaNetra; Sager, John; Li, Wenyan; Monje, Oscar

    2007-01-01

    The FY 2005 CDDF projects were selected from the following spaceport and range technology and science areas: fluid system technologies; spaceport structures and materials; command, control, and monitoring technologies; and biological sciences (including support for environmental stewardship). The FY 2005 CDDF research projects involved development of the following: a) Capacitance-based moisture sensors to optimize plant growth in reduced gravity; b) Commodity-free calibration methods; c) Application of atmospheric plasma glow discharge to alter the surface properties of polymers for improved electrostatic dissipation characteristics; d) A wipe-on, wipe-off chemical process to remove lead oxides found in paint; e) A robust metabolite profiling platform for better understanding the "law" of biological regulation; f) An explanation of the excavation processes that occur when a jet of gas impinges on a bed of sand; g) "Smart coatings" to detect and control corrosion at an early stage to prevent further corrosion h) A model that can produce a reliable diagnosis of the quality of a software product; i) The formulation of advanced materials to meet system safety needs to minimize electrostatic charges, flammability, and radiation exposure; j) A lab-based instrument that uses the electro-optic Pockels effect to make static electric fields visible; k) A passive volatile organic compound (VOC) cartridge to filter, identify, and quantify VOCs flowing into or emanating from plant flight experiments.

  10. Nuclear Systems (NS): Technology Demonstration Unit (TDU) Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The Nuclear Systems Project demonstrates nuclear power technology readiness to support the goals of NASA’s Space Technology Mission Directorate. To this end,...

  11. Members of national delegations with the Director General Luciano Maiani before the LEP Celebration

    CERN Multimedia

    Laurent Guiraud

    2000-01-01

    : front row: Mr. L. Fogas, Deputy Prime Minister, Slovak Republic; Mr. R.G. Schwartzenberg, Minister of Research, France; Mrs. A. Birules, Minister of Science & Technology, Spain; Lord Sainsbury of Turville, Minister of Science, United Kingdom; Mrs. E. Bulmahn, Minister of Education & Research, Germany; Mr. A. Ogi, President of the Confederation, Switzerland; Prof. L. Maiani, CERN Director General; Mrs. Maiani; Mr. Ph. Busquin, Commissioner for Research, European Council; Mrs. A. Bladh, State Secretary of Education & Science, Sweden; Prof. M. Gago, Minister of Science & Technology, Portugal; Prof. A. Wiszniewski, Minister of Science, Poland back row Mr. H. Eschelbacher President of Council; Mr. P. Levaux, Former Council President, Belgium; Prof. D. Dimitrov, Minister of Education & Science, Bulgaria; Dr. J. O'Fallon, Department of Energy, USA; Mr. M. Kirpichnikov, First Vice-Minister for Science, Russia; Prof. D. Deniozos, Secretary General for Research & Technology, Greece; Mr. E.S....

  12. ACTA Technology Presents EPA with Patent Copy

    Science.gov (United States)

    US EPA SBIR awardee, ACTA Technology, presented James H. Johnson, Director of the US EPA National Center for Environmental Research, and April Richards, Program Manager of the US EPA's SBIR Program, with a copy of their Red Ribbon patent.

  13. 75 FR 13766 - Food and Drug Administration and Process Analytical Technology for Pharma Manufacturing: Food and...

    Science.gov (United States)

    2010-03-23

    ... feature FDA's perspective on where PAT will be applicable in the manufacturing process and FDA's current... HUMAN SERVICES Food and Drug Administration Food and Drug Administration and Process Analytical Technology for Pharma Manufacturing: Food and Drug Administration--Partnering With Industry; Public...

  14. Wanted: Clean Coal Burning Technology

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    China is intent on developing clean coal burning technology, an objective it can achieve through installing desulfurization facilities at coal-burning power plants that will control SO2 emissions and environmental pollution. According to kuo Yi, deputy director general of the Department of Science and Technology of the State Environmental Protection Agency, China is a major coal-buming country:

  15. Rehabilitative and Assistive Technology: Overview

    Science.gov (United States)

    ... easier for a caregiver to care for a disabled person. The term “rehabilitative technology” is sometimes used to refer to aids used ... technology Adaptive devices or equipment Assistive devices and technology Communication aids Independent ... NICHD Research Advances of 2016 Getting to Know the New NICHD Director NIH to host scientific workshop on ...

  16. 78 FR 20359 - NASA Advisory Council; Technology and Innovation Committee; Meeting

    Science.gov (United States)

    2013-04-04

    ... SPACE ADMINISTRATION NASA Advisory Council; Technology and Innovation Committee; Meeting AGENCY... and Space Administration (NASA) announces a meeting of the Technology and Innovation Committee of the... Technology Mission Directorate programs; status of activities within the Office of the Chief...

  17. The role of the psychiatrist as program medical director.

    Science.gov (United States)

    Ranz, J; Stueve, A

    1998-09-01

    In a recently published survey of alumni of the Columbia University public psychiatry fellowship, respondents who were medical directors reported performing a greater variety of tasks and experiencing higher job satisfaction than those who were staff psychiatrists. Both medical directors and staff psychiatrists believed that job satisfaction was most dependent on clinical collaboration activities. Survey data were reanalyzed to determine whether there was a relationship between the frequency of tasks performed and overall job satisfaction, and whether the tasks that actually predicted overall job satisfaction were the same as those that respondents believed contributed to job satisfaction. The survey was distributed to all public psychiatry fellows and alumni in active practice (N=89), and 72 forms (81 percent) were returned. The survey consisted of 16 self-administered items divided into three categories of job tasks: direct service, clinical collaboration, and administration. Despite respondents' beliefs that clinical collaboration activities contributed most to job satisfaction, performance of administrative tasks was found to best correlate with overall job satisfaction. Furthermore, overall job satisfaction was related to the performance of administrative tasks and not to the job title of medical director alone. Most of the medical directors in the survey had program-level, rather than agency-level, responsibilities. The findings indicate that the role of program medical director can serve as a crucial next step for staff psychiatrists, offering the opportunity to perform administrative tasks, which, according to the results, improves job satisfaction in public-sector positions.

  18. The chaotic world of the nursing program director

    Directory of Open Access Journals (Sweden)

    Jean Ann Seago

    2007-12-01

    Full Text Available Aim: The environment of the nursing program dean or director within a community college or state university can be politically, fiscally, and emotionally challenging. There are few studies that investigate that environment. The purpose of this study was to describe the major barriers and incentives facing these nursing deans or directors as they implemented their proposed interventions related to the Central Valley Nursing Diversity Project. Additionally, we sought to identify successful strategies used to keep the programs competitive for resources and status within their institutions and within their local communities. Methodology: The study is descriptive; the data collection method was structured interviews and data were analyzed using content analysis.Findings: Findings indicate that among the most difficult barriers faced by the directors and the faculty was the over subscribed status (more applicants than positions of the programs. The deans or directors described three significant points that acted as barriers. These were 1 limited space in science laboratory pre-requisite courses, 2 limited classroom space in nursing courses, and 3 limited space in clinical (hospital sites. The largest single external pressure reported was the reduction in funding and all deans or directors indicated they had difficulty hiring qualified or credentialed faculty.Conclusion: Colleges must manage more effectively student demand by modifying admissions criteria to be more selective and admit students with greater likelihood of graduating; encourage innovative partnerships between employers and schools of nursing; and increasing funding for nursing faculty salaries, classrooms, and laboratories.

  19. 76 FR 78716 - Delegation of Duties, Functions, and Responsibilities Vested in the Director General of the...

    Science.gov (United States)

    2011-12-19

    ... Delegation of Duties, Functions, and Responsibilities Vested in the Director General of the Foreign Service and Director of Human Resources By virtue of the authority vested in me as Director General of the... the duties, functions, and authorities vested in me as Director General of the Foreign Service...

  20. 38 CFR 18a.4 - Duties of the Director, Contract Compliance Service.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Duties of the Director... 1964 § 18a.4 Duties of the Director, Contract Compliance Service. Upon referral by the Chief Medical Director or the Under Secretary for Benefits, the Director, Contract Compliance Service will:...