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Sample records for techniques testing strategies

  1. Supervision That Improves Teaching: Strategies and Techniques.

    Science.gov (United States)

    Sullivan, Susan; Glanz, Jeffrey

    This book offers a plan for improved classroom practice through the supervisory process. It includes hands-on practices for developing a personalized supervision strategy, research-based and empirically tested strategies, field-tested tools and techniques for qualitative and quantitative observation, a comprehensive resource of traditional and…

  2. High voltage test techniques

    CERN Document Server

    Kind, Dieter

    2001-01-01

    The second edition of High Voltage Test Techniques has been completely revised. The present revision takes into account the latest international developments in High Voltage and Measurement technology, making it an essential reference for engineers in the testing field.High Voltage Technology belongs to the traditional area of Electrical Engineering. However, this is not to say that the area has stood still. New insulating materials, computing methods and voltage levels repeatedly pose new problems or open up methods of solution; electromagnetic compatibility (EMC) or components and systems al

  3. Oberst beam test technique

    Science.gov (United States)

    Fasana, Alessandro; Garibaldi, Luigi; Giorcelli, Ermanno; Ruzzene, Massimo

    1998-06-01

    The definition of the mechanical properties of viscoelastic materials, i.e. the elastic modulus and the loss factor, is carried out, according to many national and international standards, with many different techniques, both of the resonant and non-resonant type. In this paper we focus our attention on the pros and cons of the resonant technique based on the classical Oberst beam method. When the damping material to be tested is not self-supporting, its properties are determined taking start from the measured modal frequencies and loss factors of a laminated beam, constituted by one or two metallic strips, ideally undamped, and one or two viscoelastic layers. The formulae specified on the standards hold valid under the assumptions of the theory developed by Kerwin, Ungar and Ross and we try in this paper to quantify witch deviation of the results should be expected when moving away from their ideal hypotheses.

  4. Counselor Hypothesis-Testing Strategies.

    Science.gov (United States)

    Strohmer, Douglas C.; Newman, Lisa J.

    1983-01-01

    Reports two experiments relevant to the questioning strategies counselors use in testing their hypotheses about clients. Results supported the idea that counselors are able to take a tentative hypothesis about a client and test its accuracy against additional independent, unbiased observations of the client. (LLL)

  5. Full scale lightning test technique

    Science.gov (United States)

    Walko, L. C.; Schneider, J. G.

    1980-01-01

    A test technique was developed for applying a full scale mean value (30 kiloampere peak) simulated lightning return stroke current on a complete flight ready aircraft to assess the threat of lightning to aircraft electrical circuits. A computer-aided generator design was used to establish the parameters of the test system. Data from previous work done on development of low inductance current paths determined the basic system configuration.

  6. DECIDING PRODUCTION TECHNIQUE STRATEGY BY INTEGRAL EVALUATION

    Institute of Scientific and Technical Information of China (English)

    赵景礼; 吴健; 富强

    1997-01-01

    According to overall mean square root of weighted deviation, a significant method of selecting coal mine production technique strategy has been put forward in this paper. In the given example, an index system of evaluating different mining methods has also been provided, which plays a guiding effect in production of coal mine.

  7. Environmental testing techniques for electronics and materials

    CERN Document Server

    Dummer, Geoffrey W A; Fry, D W; Higinbotham, W

    2013-01-01

    Environmental Testing Techniques for Electronics and Materials reviews environmental testing techniques for evaluating the performance of electronic equipment, components, and materials. Environmental test planning, test methods, and instrumentation are described, along with the general environmental conditions under which equipment must operate. This book is comprised of 15 chapters and begins by explaining why environmental testing is necessary and describing the environment in which electronics must operate. The next chapter considers how an environmental test plan is designed; the methods

  8. Plant Variety Protection and DUS Testing Technique

    Institute of Scientific and Technical Information of China (English)

    LI Xiao-hui; LI Xin-hai; ZHANG Shi-huang; LI Ming-shun; LI Wen-hua

    2002-01-01

    DUS testing technique used for plant variety protection was reviewed in the paper, and somesuggestions were made on how to establish the appropriate technology system in China. Meanwhile, the poten-tial exploitation of the technique was discussed.

  9. Discourse and Deliberation Testing a Collaborative Strategy

    CERN Document Server

    Walker, M A

    1995-01-01

    A discourse strategy is a strategy for communicating with another agent. Designing effective dialogue systems requires designing agents that can choose among discourse strategies. We claim that the design of effective strategies must take cognitive factors into account, propose a new method for testing the hypothesized factors, and present experimental results on an effective strategy for supporting deliberation. The proposed method of computational dialogue simulation provides a new empirical basis for computational linguistics.

  10. Fault Based Techniques for Testing Boolean Expressions: A Survey

    CERN Document Server

    Badhera, Usha; Taruna, S

    2012-01-01

    Boolean expressions are major focus of specifications and they are very much prone to introduction of faults, this survey presents various fault based testing techniques. It identifies that the techniques differ in their fault detection capabilities and generation of test suite. The various techniques like Cause effect graph, meaningful impact strategy, Branch Operator Strategy (BOR), BOR+MI, MUMCUT, Modified Condition/ Decision Coverage (MCDC) has been considered. This survey describes the basic algorithms and fault categories used by these strategies for evaluating their performance. Finally, it contains short summaries of the papers that use Boolean expressions used to specify the requirements for detecting faults. These techniques have been empirically evaluated by various researchers on a simplified safety related real time control system.

  11. Serological diagnosis of autoimmune bullous skin diseases: Prospective comparison of the BIOCHIP mosaic-based indirect immunofluorescence technique with the conventional multi-step single test strategy

    Directory of Open Access Journals (Sweden)

    van Beek Nina

    2012-08-01

    Full Text Available Abstract Background Various antigen-specific immunoassays are available for the serological diagnosis of autoimmune bullous diseases. However, a spectrum of different tissue-based and monovalent antigen-specific assays is required to establish the diagnosis. BIOCHIP mosaics consisting of different antigen substrates allow polyvalent immunofluorescence (IF tests and provide antibody profiles in a single incubation. Methods Slides for indirect IF were prepared, containing BIOCHIPS with the following test substrates in each reaction field: monkey esophagus, primate salt-split skin, antigen dots of tetrameric BP180-NC16A as well as desmoglein 1-, desmoglein 3-, and BP230gC-expressing human HEK293 cells. This BIOCHIP mosaic was probed using a large panel of sera from patients with pemphigus vulgaris (PV, n = 65, pemphigus foliaceus (PF, n = 50, bullous pemphigoid (BP, n = 42, and non-inflammatory skin diseases (n = 97 as well as from healthy blood donors (n = 100. Furthermore, to evaluate the usability in routine diagnostics, 454 consecutive sera from patients with suspected immunobullous disorders were prospectively analyzed in parallel using a the IF BIOCHIP mosaic and b a panel of single antibody assays as commonly used by specialized centers. Results Using the BIOCHIP mosaic, sensitivities of the desmoglein 1-, desmoglein 3-, and NC16A-specific substrates were 90%, 98.5% and 100%, respectively. BP230 was recognized by 54% of the BP sera. Specificities ranged from 98.2% to 100% for all substrates. In the prospective study, a high agreement was found between the results obtained by the BIOCHIP mosaic and the single test panel for the diagnosis of BP, PV, PF, and sera without serum autoantibodies (Cohen’s κ between 0.88 and 0.97. Conclusions The BIOCHIP mosaic contains sensitive and specific substrates for the indirect IF diagnosis of BP, PF, and PV. Its diagnostic accuracy is comparable with the conventional multi

  12. High-voltage test and measuring techniques

    Energy Technology Data Exchange (ETDEWEB)

    Hauschild, Wolfgang; Lemke, Eberhard

    2014-04-01

    Reflects the unit of both HV testing and measuring technique. Intended as an ''application guide'' for the relevant IEC standards. Refers also to future trends in HV testing and measuring technique. With numerous illustrations. It is the intent of this book to combine high-voltage (HV) engineering with HV testing technique and HV measuring technique. Based on long-term experience gained by the authors as lecturer and researcher as well as member in international organizations, such as IEC and CIGRE, the book will reflect the state of the art as well as the future trends in testing and diagnostics of HV equipment to ensure a reliable generation, transmission and distribution of electrical energy. The book is intended not only for experts but also for students in electrical engineering and high-voltage engineering.

  13. Vocabulary test Strategies used by the Students to answer Vocabulary Test the Reading Comprehension of TOEFL

    Directory of Open Access Journals (Sweden)

    Suyatman Suyatman

    2017-10-01

    Full Text Available Test of English as a foreign Language or TOEFL is a standardized test of English for non-native speaker. It consists of three parts or three sections of tests. In Reading Comprehension test, it consists of vocabulary test. To get better result of score, it needs strategies. The purposes of this study are to know the strategies used by the students to answer the vocabulary test on reading section of TOEFL, to know the most strategy used by the students, to know the least strategy used by the students and to know the distribution of strategies used by the students to answer the Vocabulary test of Reading Comprehension of the TOEFL. The researcher used descriptive qualitative research. The subject was twelve students. The instrument was questionnaire that consisted of thirty questions. Data analyzes technique was by using mean score. The result of the research showed that; (1 students used all strategies to answer the vocabulary test of reading comprehension of TOEFL. (2 the most strategies used by the students was ‘Looking for contextual clues to the meaning of unknown words.(3 the least strategy used by the students to answer vocabulary test was ‘Developing a new vocabulary study system, and (4 the distribution of the strategy number 1 was 3.88,strategy number 2 was 3.61, number 3 was 2.94, number four was 2.91, strategy number 5 was3.88, strategy number six was 3.47, strategy number seven was 3.69, strategy number eight was 3.02, strategy number nine was 3.00 and the last strategy was 3.13.

  14. Testing Strategies for Model-Based Development

    Science.gov (United States)

    Heimdahl, Mats P. E.; Whalen, Mike; Rajan, Ajitha; Miller, Steven P.

    2006-01-01

    This report presents an approach for testing artifacts generated in a model-based development process. This approach divides the traditional testing process into two parts: requirements-based testing (validation testing) which determines whether the model implements the high-level requirements and model-based testing (conformance testing) which determines whether the code generated from a model is behaviorally equivalent to the model. The goals of the two processes differ significantly and this report explores suitable testing metrics and automation strategies for each. To support requirements-based testing, we define novel objective requirements coverage metrics similar to existing specification and code coverage metrics. For model-based testing, we briefly describe automation strategies and examine the fault-finding capability of different structural coverage metrics using tests automatically generated from the model.

  15. Regional strategy tested in Caribbean.

    Science.gov (United States)

    1984-01-01

    Barbados, St. Vincent, and St. Lucia have joined forces in the world's 1st regional Contraceptive Social Marketing (CSM) effort -- the Caribbean CSM. The Barbados Family Planning Association (BFPS) is overseeing the operation, which begins selling 2 contraceptive pills and a condom in early February. Costs and start-up times were shaved by adopting brand names and advertising materials from Jamaica's highly successful CSM project. Jamaica's popular "Panther" condom and "Perle" oral contraceptive (OC) are being used by the Caribbean CSM project. Perle's 9-year-old package has been redesigned and the Caribbean CSM project also is selling a 2nd, low-dose version called "Perle-LD." The products are manufactured in the US by Syntex as Noriday and Norminest, respectively. But the regional approach's financial gains also had a debit side, most notably a tripling of bureaucratic procedures. Part of project difficulties stem from differences among the 3 Caribbean countries. While sharing a common cultural heritage, St. Lucians speak a patois dialect in addition to the English prevalent on the other islands. The biggest hurdle was overcoming an economic disparity between Barbados and its less affluent neighbors, St. Vincent and St. Lucia. The CSM project decided to try a 2-tier product pricing strategy. In US currency, prices run $1.75 per cycle for both OCs on Barbados, but $1.26 on St. Vincent and St. Lucia. A Panther 3-pack costs 75 cents on Barbados and 42 cents on the othe 2 islands. The project is being promoted with generic family planning media advertisements. The project also has held physician orientation seminars on each island. The pilot program will be accompanied by retailer training seminars. In addition the project may introduce a spermicidal foaming tablet, once the US Food and Drug Administration approvs a new American-made product. The unique Caribbean CSM project may spread an idea as potent as the family planning message. Its success could transmit the

  16. Test Concept for Advanced Oxidation Techniques

    DEFF Research Database (Denmark)

    Bennedsen, Lars Rønn; Søgaard, Erik Gydesen; Mortensen, Lars

    of conducting screening laboratory and pilot tests prior to onset of full scale treatment of a contaminated site with a given technology. For this purpose, Ramboll has developed a mobile test unit in co-operation with universities and technology suppliers. The unit includes equipment for both standard and more...... of success. Based on the wide selection of different techniques, several screening matrices have been developed in order to make it easier to choose the best suited technique for a given situation. However, these matrices only provide an indication of which technology that might be effective and often...... the assessor ends up with 3 or 4 applicable techniques. In stead of selecting a full scale technique solely based on information collected during a literature research, it is best practice to supplement the remediation screening phase with laboratory and in situ pilot treatability tests. As well...

  17. Magnetic Nondestructive Testing Techniques of Constructional Steel

    Directory of Open Access Journals (Sweden)

    Xiong Er-gang

    2016-01-01

    Full Text Available Steel is a kind of ferromagnetic material, which is extensively applied in such fields as buildings, bridges, railways, machines and lifeline engineering etc. Those engineering structures built of constructional steel will unavoidably experience some damages during their service lifetime, thus which will influence the distribution regularity of internal forces in structures, result in over-stresses, cause the local failure of structures, and even lead to collapse of the whole structure. Therefore, it is a pressing topic to study how to directly evaluate the real-time stressed states of structural members, damages and steel characteristics in present structural health monitoring and diagnosing fields. And the achievements of this research will be of theoretical significance and of application value of engineering. This paper summarizes varieties of new magnetic nondestructive testing techniques used in constructional steel, respectively investigates the testing principles, characteristics and application for the magnetic Barkhausen noise technique, magnetic acoustic emission technique, magnetic flux leakage technique, magnetic memory technique and magnetic absorption technique, and points out the problems present in the application of these new techniques to actual testing and the further research objective.

  18. Test techniques for cryogenic wind tunnels

    Science.gov (United States)

    Lawing, Pierce L.

    1989-01-01

    Some of the testing techniques developed for transonic cryogenic tunnels are presented. Techniques are emphasized which required special development or were unique because of the opportunities offered by cryogenic operation. Measuring the static aerodynamic coefficients normally used to determine component efficiency is discussed. The first topic is testing of two dimensional airfoils at transonic Mach numbers and flight values of Reynolds number. Three dimensional tests of complete configurations and sidewall mounted wings are also described. Since flight Reynolds numbers are of interest, free transition must be allowed. A discussion is given of wind tunnel and model construction effects on transition location. Time dependent phenomena, fluid mechanics, and measurement techniques are examined. The time dependent, or unsteady, aerodynamic test techniques described include testing for flutter, buffet, and oscillating airfoil characteristics. In describing non-intrusive laser techniques, discussions are given regarding optical access, seeding, forward scatter lasers, two-spot lasers, and laser holography. Methods of detecting transition and separation are reported and a new type of skin friction balance is described.

  19. Methods and Strategies: The Reflective Assessment Technique

    Science.gov (United States)

    Kennedy, Cathleen; Long, Kathy; Camins, Arthur

    2009-01-01

    Teachers often rely on student questions, their observations of students at work, and their own intuition to monitor how well students are learning. However, the authors found that teachers learn more about their students when they use the four-step Reflective Assessment Technique that draws on guided teacher reflections to inform classroom…

  20. Practical Motivational Techniques for Preservice Teachers and Instructional Design Strategies.

    Science.gov (United States)

    Schnackenberg, Heidi L.

    This paper describes educational units for preservice teachers that pertain to specific practical motivational techniques for the preservice teachers to use in their classrooms (grades K-12). The units are designed so that students will be able to name four motivational techniques, select the strategy that exemplifies a motivational technique, and…

  1. Language Learning Strategies and Test Anxiety

    Science.gov (United States)

    Shomoossi, Nematullah; Kooshan, Mohsen; Ketabi, Saeed

    2008-01-01

    The role of learner's strategies and skills in learning a foreign language has been investigated in the last three decades. However, the part it plays in ESP achievement tests is not seriously treated. Moreover, as students take the final exam, their chief complaint concerns the idea of test anxiety as a debilitating factor. Therefore, the present…

  2. Building a successful board-test strategy

    CERN Document Server

    Scheiber, Stephen

    2001-01-01

    Written in a clear and thoughtful style, Building a Successful Board-Test Strategy, Second Edition offers an integrated approach to the complicated process of developing the test strategies most suited to a company's profile and philosophy. This book also provides comprehensive coverage of the specifics of electronic test equipment as well as those broader issues of management and marketing that shape a manufacturer's ""image of quality.""In this new edition, the author adds still more ""war stories,"" relevant examples from his own experience, which will guide his readers in their dec

  3. High-voltage test and measuring techniques

    CERN Document Server

    Hauschild, Wolfgang

    2014-01-01

    It is the intent of this book to combine high-voltage (HV) engineering with HV testing technique and HV measuring technique. Based on long-term experience gained by the authors as lecturer and researcher as well as member in international organizations, such as IEC and CIGRE, the book will reflect the state of the art as well as the future trends in testing and diagnostics of HV equipment to ensure a reliable generation, transmission and distribution of electrical energy. The book is intended not only for experts but also for students in electrical engineering and high-voltage engineering.

  4. LHC Magnet Tests Operational Techniques and Empowerment for Successful Completion

    CERN Document Server

    Chohan, V; Priestnall, K; Pirotte, F; Veyrunes, E; Ali, N; Awale, P; Bahuguna, S; Bhunia, U; Chauhan, V; Dixit, M; Gore, J; John, J; Kandaswamy, E; Kasbekar, A; Kashyap, P; Kasliwal, A; Kulkarni, C; Laddha, A; Malhotra, S; Mascarenhas, M; Mishra, J; Motiwala, P; Nair, K; Narayanan, R; Padmakumar, S; Pagare, A; Peruppayikkad, D; Raghunathan, S; Rao, S; Roy, D; Sharma, S; Shimjith, S; Singh, S; Sonnis, S; Sridhar, S; Surendran, P; Tikaria, A

    2007-01-01

    The LHC magnet tests operation team developed various innovative techniques, particularly since early 2004, to complete the superconductor magnet tests by Feb. 2007. Overall and cryogenic priority handling, rapid on-bench thermal cycling, rule-based goodness evaluation on round-the-clock basis, multiple, mashed web systems are some of these techniques applied with rigour for successful tests completion in time. This paper highlights these operation empowerment tools which had a pivotal role for success. A priority handling method was put in place to enable maximum throughput from twelve test benches, having many different constraints. For the cryogenics infrastructure, it implied judicious allocation of limited resources to the benches. Rapid On-Bench Thermal Cycle was a key strategy to accelerate magnets tests throughput, saving time and simplifying logistics. First level magnet appraisal was developed for 24 hr decision making so as to prepare a magnet further for LHC or keep it on standby. Web based system...

  5. A Review of Constraint-Handling Techniques for Evolution Strategies

    OpenAIRE

    Oliver Kramer

    2010-01-01

    Evolution strategies are successful global optimization methods. In many practical numerical problems constraints are not explicitly given. Evolution strategies have to incorporate techniques to optimize in restricted solution spaces. Famous constraint-handling techniques are penalty and multiobjective approaches. Past work has shown that in particular an ill-conditioned alignment between the coordinate system of Gaussian mutation and the constraint boundaries leads to premature convergence. ...

  6. Practical Strategies to Improve Test Efficiency

    Institute of Scientific and Technical Information of China (English)

    DING Zhigang; WANG Hongcheng; LING Lianghe

    2007-01-01

    This paper introduces strategies to detect software bugs in earlier life cycle stage in order to improve test efficiency. Static analysis tool is one of the effective methods to reveal software bugs during software development. Three popular static analysis tools are introduced, two of which, PolySpace and Splint, are compared with each other by analyzing a set of test cases generatedd by the authors. PolySpace can reveal 60% bugs with 100% R/W ratio (ratio of real bugs and total warnings), while Splint reveal 73.3% bugs with 44% R/W ratio. And they are good at finding different categories of bugs. Two strategies are concluded to improve test efficiency, under the guideline that static analysis tools should be used in finding different categories of bugs according to their features. The first one aims at finding bugs as many as possible, while the second concentrates to reduce the average time on bug revelation. Experimental data shows the first strategy can find 100% bugs with 60% RAN ratio, the second one find 80% bugs with 66.7% R/W ratio. Experiment results prove that these two strategies can improve the test efficiency in both fault coverage and testing time.

  7. A Method to Test Model Calibration Techniques

    Energy Technology Data Exchange (ETDEWEB)

    Judkoff, Ron; Polly, Ben; Neymark, Joel

    2016-08-26

    This paper describes a method for testing model calibration techniques. Calibration is commonly used in conjunction with energy retrofit audit models. An audit is conducted to gather information about the building needed to assemble an input file for a building energy modeling tool. A calibration technique is used to reconcile model predictions with utility data, and then the 'calibrated model' is used to predict energy savings from a variety of retrofit measures and combinations thereof. Current standards and guidelines such as BPI-2400 and ASHRAE-14 set criteria for 'goodness of fit' and assume that if the criteria are met, then the calibration technique is acceptable. While it is logical to use the actual performance data of the building to tune the model, it is not certain that a good fit will result in a model that better predicts post-retrofit energy savings. Therefore, the basic idea here is that the simulation program (intended for use with the calibration technique) is used to generate surrogate utility bill data and retrofit energy savings data against which the calibration technique can be tested. This provides three figures of merit for testing a calibration technique, 1) accuracy of the post-retrofit energy savings prediction, 2) closure on the 'true' input parameter values, and 3) goodness of fit to the utility bill data. The paper will also discuss the pros and cons of using this synthetic surrogate data approach versus trying to use real data sets of actual buildings.

  8. Advances in DUS Test Technique for Coconut

    Institute of Scientific and Technical Information of China (English)

    Ling GAO; Li XU; Difa LlU; Rulian ZHANG

    2014-01-01

    As great progress has been made in the field of protection of new plant varieties, more attention is paid to the standardization of DUS (Distinctness, Unifor-mity, and Stability) test procedure. For further studies of tropical plants as their im-portance in agriculture and germplasm, protection of coconut becomes more signifi-cant and thus DUS test technique of coconut is needed. ln this essay, we analyzed the status quo of the DUS test guidelines by lnternational Union for the Protection of New Varieties of Plants (UPOV proj.3) and national DUS test guidelines in Chi-na, and provided some suggestions or promotions for improving the guidelines of DUS test in coconut.

  9. An Author's Storyboard Technique as a Prewriting Strategy.

    Science.gov (United States)

    Harrington, Suzanne L.

    1994-01-01

    Describes an author's storyboard technique which elementary school students used as a prewriting strategy to roughly sketch out stories on the storyboard frames. Suggests that the technique helps students to plan and organize their stories and helps reluctant writers find the motivation to write. (SR)

  10. Electronic test instrumentation and techniques: A compilation

    Science.gov (United States)

    1974-01-01

    The uses of test equipment and techniques used in space research and development programs are discussed. Modifications and adaptations to enlarge the scope of usefulness or divert the basic uses to alternate applications are analyzed. The items of equipment which have been of benefit to professional personnel in the enlargement and improvement of quality control capabilities are identified. Items which have been simplified or made more accurate in conducting measurements are described.

  11. A Review of Constraint-Handling Techniques for Evolution Strategies

    Directory of Open Access Journals (Sweden)

    Oliver Kramer

    2010-01-01

    Full Text Available Evolution strategies are successful global optimization methods. In many practical numerical problems constraints are not explicitly given. Evolution strategies have to incorporate techniques to optimize in restricted solution spaces. Famous constraint-handling techniques are penalty and multiobjective approaches. Past work has shown that in particular an ill-conditioned alignment between the coordinate system of Gaussian mutation and the constraint boundaries leads to premature convergence. Covariance matrix adaptation evolution strategies offer a solution to this alignment problem. Last, metamodeling of the constraint boundary leads to significant savings of constraint function calls and to a speedup by repairing infeasible solutions. This work gives a brief overview over constraint-handling methods for evolution strategies by demonstrating the approaches experimentally on two exemplary constrained problems.

  12. AN EFFECTIVE ENGLISH CLASS WITH APPROPRIATE TECHNIQUES AND STRATEGIES

    Directory of Open Access Journals (Sweden)

    Vahidije Kadiu

    2016-09-01

    Full Text Available Teaching is considered to be one of the most important aspects for the future of the human beings. The fact that teaching is an art based on techniques and strategies is very important. The aim of this paper is to study the appropriate techniques and strategies for an effective English class. To achieve this, a survey was conducted at “Asim Vokshi secondary school. The main instrument used was a questionnaire. It was conducted on 70 students and 70 teachers. According to the results of the survey, many teachers believe that during an English class, different techniques and strategies should be included such as: cooperation, control of the class, and motivation. They also stressed the fact that four skills should be co-related for an effective class.  The most important finding was related to the students. According to them, the best way to learn the English language was by writing.

  13. A Fractual Mechanical Testing and Design Strategy for FRC Structures

    DEFF Research Database (Denmark)

    Stang, Henrik; Olesen, John Forbes

    1999-01-01

    A unified testing and design strategy for fibre reinforced concrete structures is summarised. The strategy is based on fracture mechanical concepts. Emphasis is placed on material characterisation and testing specifications.......A unified testing and design strategy for fibre reinforced concrete structures is summarised. The strategy is based on fracture mechanical concepts. Emphasis is placed on material characterisation and testing specifications....

  14. A Fractual Mechanical Testing and Design Strategy for FRC Structures

    DEFF Research Database (Denmark)

    Stang, Henrik; Olesen, John Forbes

    1999-01-01

    A unified testing and design strategy for fibre reinforced concrete structures is summarised. The strategy is based on fracture mechanical concepts. Emphasis is placed on material characterisation and testing specifications.......A unified testing and design strategy for fibre reinforced concrete structures is summarised. The strategy is based on fracture mechanical concepts. Emphasis is placed on material characterisation and testing specifications....

  15. Application of Creativity Techniques in the Creation of Organizational Strategies

    Directory of Open Access Journals (Sweden)

    Alireza Aslani

    2012-08-01

    Full Text Available The majority of studies in the field of organizational strategies have concentrated on strategy formulation, distinct from strategy implementation. Disunion of these two processes often leads to disappointing results in the implementation of strategy. In such a condition, the creation of a suitable strategy in a way that could resolve the divergence of formulation from implementation is suggested by researchers. This means that the implementers of a strategy turn into the formulators. Therefore, presenting creative ideas and solutions is encouraged between related organizational staff at different levels. Noting that the possibility of emerging creative ideas in organizational meetings between persons from different organizational levels is low, fostering creativity and innovation techniques can be an ideal solution for successful group meetings. In this paper, after introducing the effective criteria that should be considered in the creation of collective action strategies in organizations, the suitable techniques for fostering creativity in this kind of meeting will be ranked based on the Fuzzy MADM approach.

  16. Strategies in the application of the Donnan membrane technique.

    NARCIS (Netherlands)

    Weng, L.P.; Vega, F.A.; Riemsdijk, van W.H.

    2011-01-01

    e Donnan membrane technique (DMT) can be applied to measure free ion concentrations both in laboratory and in situ in the field. In designing DMT experiments, different strategies can be taken, depending on whether accumulation is needed. (1) When the free ion concentration is above the detection li

  17. Techniques and Strategies of Language Use In Global Business Negotiation

    Institute of Scientific and Technical Information of China (English)

    许泽芳

    2012-01-01

    A successful negotiation needs the perfect combination of appropriate language use and flexible negotiation strategies.This paper,through discussing techniques of language use in global business negotiation a with some examples,tries to help improve the efficiency of international business negotiation.

  18. Definition of IMR antenna test techniques

    Science.gov (United States)

    Vokurka, V. J.

    1984-09-01

    Compact antenna test ranges (CR) with two cylindrical reflectors are compared with other indoor techniques. It is shown that only CR create an electromagnetic field environment suitable for far field simulation. The reflectivity level of CR is better than that of other (indoor and outdoor) ranges. Levels as low as -70 dB are realistic; this implies that an important source of errors in pattern measurements is eliminated. The cross-polar level is relatively high for linear polarization (vertical plane only), but accurate cross-polar measurements are possible. Errors due to amplitude taper are acceptable even for antennas which occupy 60% of the CR dimension (linear). Phase characteristics are almost perfect.

  19. Development of testing techniques for mine fan performance

    Institute of Scientific and Technical Information of China (English)

    WU Zheng-yan; JIANG Shu-guang; PENG Dan-ren

    2006-01-01

    Three progressive stages of testing techniques are elaborated, which are entirely manual operating, taking separate instruments testing and computer program controlling. The testing method and principle are detailed based on the testing process for meteorological parameters, air pressure, air quality and rotating velocity. And every testing technique is analyzed. Finally, the technique outlook is viewed. All this plays a leading role in development of the testing techniques.

  20. Preparation Techniques and Syntactical Strategies for Simultaneous Interpreting

    Institute of Scientific and Technical Information of China (English)

    夏晶晶

    2013-01-01

    This essay is a case study of an interpreting exam recording about a speech by President Bush on the topic of energy security and climate change, this paper discussed preparation techniques and syntactical strategies for simultaneous interpreting. The research shows that interpreting excellency is based on a sound preparation. Anticipating and waiting strategies enable a natural output. Waiting could cause overloaded memory. Integrating can benefit interpreting by saving time and energy, especially in information-intensive ST. A mix of stalling and chunking can be used to deal with long and complex sentences but interpreters should be cautious on adding linking words, which may undermine the preciseness of the ST.

  1. Efficient Plant Supervision Strategy Using NN Based Techniques

    Science.gov (United States)

    Garcia, Ramon Ferreiro; Rolle, Jose Luis Calvo; Castelo, Francisco Javier Perez

    Most of non-linear type one and type two control systems suffers from lack of detectability when model based techniques are applied on FDI (fault detection and isolation) tasks. In general, all types of processes suffer from lack of detectability also due to the ambiguity to discriminate the process, sensors and actuators in order to isolate any given fault. This work deals with a strategy to detect and isolate faults which include massive neural networks based functional approximation procedures associated to recursive rule based techniques applied to a parity space approach.

  2. Linking human factors to corporate strategy with cognitive mapping techniques.

    Science.gov (United States)

    Village, Judy; Greig, Michael; Salustri, Filippo A; Neumann, W Patrick

    2012-01-01

    For human factors (HF) to avoid being considered of "side-car" status, it needs to be positioned within the organization in such a way that it affects business strategies and their implementation. Tools are needed to support this effort. This paper explores the feasibility of applying a technique from operational research called cognitive mapping to link HF to corporate strategy. Using a single case study, a cognitive map is drawn to reveal the complex relationships between human factors and achieving an organization's strategic goals. Analysis of the map for central concepts and reinforcing loops enhances understanding that can lead to discrete initiatives to facilitate integration of HF. It is recommended that this technique be used with senior managers to understand the organizations` strategic goals and enhance understanding of the potential for HF to contribute to the strategic goals.

  3. Transcatheter aortic valve replacement: techniques, complications, and bailout strategies.

    Science.gov (United States)

    Singh, Vikas; Macon, Conrad J; Scot Shaw, Eric; Londoño, Juan C; Martinez, Claudia A

    2013-09-01

    Transcatheter aortic valve replacement has emerged as an alternative option for inoperable or very high-risk patients with severe aortic stenosis-however, there are serious complications associated with the procedure, such as patient mortality, stroke, conduction disturbances, paravalvular regurgitation, and vascular concerns. Our review focuses on the most common complications related to transcatheter aortic valve replacement procedures and potential bailout strategies and techniques.

  4. Column-coupling strategies for multidimensional electrophoretic separation techniques.

    Science.gov (United States)

    Kler, Pablo A; Sydes, Daniel; Huhn, Carolin

    2015-01-01

    Multidimensional electrophoretic separations represent one of the most common strategies for dealing with the analysis of complex samples. In recent years we have been witnessing the explosive growth of separation techniques for the analysis of complex samples in applications ranging from life sciences to industry. In this sense, electrophoretic separations offer several strategic advantages such as excellent separation efficiency, different methods with a broad range of separation mechanisms, and low liquid consumption generating less waste effluents and lower costs per analysis, among others. Despite their impressive separation efficiency, multidimensional electrophoretic separations present some drawbacks that have delayed their extensive use: the volumes of the columns, and consequently of the injected sample, are significantly smaller compared to other analytical techniques, thus the coupling interfaces between two separations components must be very efficient in terms of providing geometrical precision with low dead volume. Likewise, very sensitive detection systems are required. Additionally, in electrophoretic separation techniques, the surface properties of the columns play a fundamental role for electroosmosis as well as the unwanted adsorption of proteins or other complex biomolecules. In this sense the requirements for an efficient coupling for electrophoretic separation techniques involve several aspects related to microfluidics and physicochemical interactions of the electrolyte solutions and the solid capillary walls. It is interesting to see how these multidimensional electrophoretic separation techniques have been used jointly with different detection techniques, for intermediate detection as well as for final identification and quantification, particularly important in the case of mass spectrometry. In this work we present a critical review about the different strategies for coupling two or more electrophoretic separation techniques and the

  5. Mobile Software Testing – Automated Test Case Design Strategies

    Directory of Open Access Journals (Sweden)

    Selvam R,

    2011-04-01

    Full Text Available Mobile devices are poised to challenge PCs as the application platform of choice, with 500 million mobile internet devices expected to ship in 2012 compared to 150 million PCs. The convergence ofall digital devices into mobile platform model augments the software companies, software developer, and venture capitalist firms to turn their focus into mobile application platform (for example mobile social networking application like face book and mobile VOIP like Skype a futuristic platform for increased revenue, new challenges and growth potential. But the commercial success of these applications depends on their working smoothly and securely on a wide variety of handheld devices and wireless networks. More and more virtual mobile application stores are built on the web. The web itself is in the transforming form to adapt to the mobile devices to thrive on. The sudden growth in the mobile application and the complexity in the divergence of the devices that uses these applications present increased challenges and opportunities for the software testing companies and software testers to conquerthis small device. Performing such testing quickly and cost-effectively greatly expands the market for such applications. This paper deals the nuances of Automated Test Case Design Strategies for Mobile Software Testing.

  6. Progress and Strategies for Testing of Materials for Solar Panels

    Energy Technology Data Exchange (ETDEWEB)

    Kurtz, Sarah

    2017-04-25

    Accelerated testing is key to confident launch of a new product. However, for new products like solar panels, the best approach is not always clear. The challenge for materials manufacturers is that test times can be long. Also, small-coupon testing may not predict the behavior in the full-size module, but testing of the full-size module is too expensive. As a result, solar panel test standards like IEC 61215 are useful, but are not sufficient. Material manufacturers have needed to define their own test protocols. This presentation will review some historical data (e.g., data show that manufacturers are making great progress toward reducing encapsulant discoloration) and describe advances in material testing (for example, new techniques are being demonstrated on how to more quantitatively assess adhesion, detect tendency for delamination, and understand how encapsulant properties affect other properties like cracking of cells). The International PV Quality Assurance Task Force has been researching climate-specific weathering tests toward the goal of defining international standards that would simplify qualification and quality assurance testing for materials. The status of these tests and the strategies for how to organize these standards to best meet the needs of the industry will be discussed.

  7. [Current operative techniques and strategies in endocrine surgery].

    Science.gov (United States)

    Gürtler, Thomas; Weber, Markus

    2011-06-01

    Technical advances and focusing on subsets modified endocrine surgery in the last ten years tremendously. There is on one side a clear trend towards minimal invasive approaches, first of all in the surgery of the adrenal glands, where the transperitoneal or retroperitoneal laparoscopic adrenalectomy has become the gold standard for tumors up to a size of 10 cm in diameter. But also in pancreatic endocrine surgery for small tumors localized in the pancreas tail and up to a certain extend in thyroid and parathyroid surgery, laparoscopic or video assisted techniques are used. On the other side more precise techniques allow a more complete and radical removal of endocrine tissue, especially in thyroid surgery. This article presents a summary of current operative techniques and strategies in endocrine surgery.

  8. ADBT Frame Work as a Testing Technique: An Improvement in Comparison with Traditional Model Based Testing

    Directory of Open Access Journals (Sweden)

    Mohammed Akour

    2016-05-01

    Full Text Available Software testing is an embedded activity in all software development life cycle phases. Due to the difficulties and high costs of software testing, many testing techniques have been developed with the common goal of testing software in the most optimal and cost-effective manner. Model-based testing (MBT is used to direct testing activities such as test verification and selection. MBT is employed to encapsulate and understand the behavior of the system under test, which supports and helps software engineers to validate the system with various likely actions. The widespread usage of models has influenced the usage of MBT in the testing process, especially with UML. In this research, we proposed an improved model based testing strategy, which involves and uses four different diagrams in the testing process. This paper also discusses and explains the activities in the proposed model with the finite state model (FSM. The comparisons have been done with traditional model based testings in terms of test case generation and result.

  9. Deep Borehole Field Test Laboratory and Borehole Testing Strategy

    Energy Technology Data Exchange (ETDEWEB)

    Kuhlman, Kristopher L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Brady, Patrick V. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); MacKinnon, Robert J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Heath, Jason E. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Herrick, Courtney G. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Jensen, Richard P. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gardner, W. Payton [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Sevougian, S. David [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Bryan, Charles R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Jang, Je-Hun [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Stein, Emily R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Bauer, Stephen J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Daley, Tom [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Freifeld, Barry M. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Birkholzer, Jens [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Spane, Frank A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2016-09-19

    Deep Borehole Disposal (DBD) of high-level radioactive wastes has been considered an option for geological isolation for many years (Hess et al. 1957). Recent advances in drilling technology have decreased costs and increased reliability for large-diameter (i.e., ≥50 cm [19.7”]) boreholes to depths of several kilometers (Beswick 2008; Beswick et al. 2014). These advances have therefore also increased the feasibility of the DBD concept (Brady et al. 2009; Cornwall 2015), and the current field test design will demonstrate the DBD concept and these advances. The US Department of Energy (DOE) Strategy for the Management and Disposal of Used Nuclear Fuel and High-Level Radioactive Waste (DOE 2013) specifically recommended developing a research and development plan for DBD. DOE sought input or expression of interest from States, local communities, individuals, private groups, academia, or any other stakeholders willing to host a Deep Borehole Field Test (DBFT). The DBFT includes drilling two boreholes nominally 200m [656’] apart to approximately 5 km [16,400’] total depth, in a region where crystalline basement is expected to begin at less than 2 km depth [6,560’]. The characterization borehole (CB) is the smaller-diameter borehole (i.e., 21.6 cm [8.5”] diameter at total depth), and will be drilled first. The geologic, hydrogeologic, geochemical, geomechanical and thermal testing will take place in the CB. The field test borehole (FTB) is the larger-diameter borehole (i.e., 43.2 cm [17”] diameter at total depth). Surface handling and borehole emplacement of test package will be demonstrated using the FTB to evaluate engineering feasibility and safety of disposal operations (SNL 2016).

  10. Compatibility testing of energetic materials, which technique?

    NARCIS (Netherlands)

    Klerk, W.P.C. de; Schrader, M.A.; Steen, A.C. van der

    1999-01-01

    Compatibility is an important safety aspect related to the production and storage of energetic materials. To test different combinations of materials a simple test method with clear criteria is advisable. At the last ESTAC the use of microcalorimetry and the vacuum stability test for the

  11. Decellularization Strategies for Regenerative Medicine: From Processing Techniques to Applications

    Directory of Open Access Journals (Sweden)

    Anna Gilpin

    2017-01-01

    Full Text Available As the gap between donors and patients in need of an organ transplant continues to widen, research in regenerative medicine seeks to provide alternative strategies for treatment. One of the most promising techniques for tissue and organ regeneration is decellularization, in which the extracellular matrix (ECM is isolated from its native cells and genetic material in order to produce a natural scaffold. The ECM, which ideally retains its inherent structural, biochemical, and biomechanical cues, can then be recellularized to produce a functional tissue or organ. While decellularization can be accomplished using chemical and enzymatic, physical, or combinative methods, each strategy has both benefits and drawbacks. The focus of this review is to compare the advantages and disadvantages of these methods in terms of their ability to retain desired ECM characteristics for particular tissues and organs. Additionally, a few applications of constructs engineered using decellularized cell sheets, tissues, and whole organs are discussed.

  12. A Rorschach Test for Visual Classification Strategies

    Science.gov (United States)

    Watson, Andrew B.; Rosenholtz, Ruth; Null, Cynthia H. (Technical Monitor)

    1996-01-01

    Contemporary models of pattern, detection and discrimination often employ template matching, but there have been few direct tests of this proposition. Adopting a method developed by Ahumada, we have analyzed how human observers discriminate between two letters of the alphabet ('c' and 'x'). The stimulus consisted of a one degree tall letter plus a four degree field of static white noise, both displayed for 16 frames at a 67 Hz frame rate. Our font and display dimensions approximated those of Solomon and Pelli. The observer identified the letter presented. A QUEST staircase varied letter contrast to maintain a 75% correct rate. For each trial, we preserved the information required to reconstruct the noise field. Possible trial categories based on (signal, response) pairs are: (c,c), (c,x), (x,c), (x,x). Noise fields were averaged separately for each category, and a final classification image was obtained by averaging the four mean images after inverting the sign of categories in which x was the response. If the observer employs a template, it should be revealed in the classification image. The lowpass-filtered classification image derived from 2048 responses of one observer is shown here, along with the corresponding ideal template. An approximation to the ideal template can be seen appropriately located within the classification image. We have also simulated and will discuss the classification images expected from various discrimination models in this experimental context. The construction of classification images appears to be a powerful tool for studying classification strategies used by human observers. Like a Rorschach test, it surreptitiously discovers the inner desires of the visual system.

  13. Postcoital test: physiologic basis, technique, and interpretation.

    Science.gov (United States)

    Moghissi, K S

    1976-02-01

    The postcoital test determines the adequacy of sperm and the receptivity of cervical mucus. It is the only test which evaluates the interaction between sperm and the female genital tract fluids. The Sims-Huhner test should be an integral part of an infertility investigation, but it must not be used as a substitute for semen analysis. Since cervical mucus accurately reflects the ovarian cycle, the PC test is a useful indicator of the endocrine preparation of the female reproductive system. It is also an important method for the evaluation of a variety of contraceptive steroids which may act directly or indirectly upon cervical secretion. For best results the test should be properly timed, meticulously performed, and knowledgeably interpreted.

  14. Testbed For Aerothermal Test Technique Development Project

    Data.gov (United States)

    National Aeronautics and Space Administration — It is proposed that a very low cost wind tunnel could be developed at JSC to provide engineers with the ability to directly run small tests focused on improving...

  15. Natural language processing techniques for automatic test ...

    African Journals Online (AJOL)

    Journal of Computer Science and Its Application ... The questions were generated by first extracting the text from the materials supplied by the ... Keywords: Discourse Connectives, Machine Learning, Automatic Test Generation E-Learning.

  16. Experimental comparison of different oscillation-based test techniques in an analog block

    Science.gov (United States)

    Suenaga, Kay; Picos, Rodrigo; Bota, Sebastia; Roca, Miquel; Garcia-Moreno, Eugeni

    2005-06-01

    This paper experimentally analyses the capabilities of an Oscillation-Based Test technique for diagnosis purposes. To evaluate the feasibility of this test strategy, the technique is applied to an Operational Transconductance Amplifier with fault injection capabilities. The application of this methodology has low impact on circuit performances. Voltage and current magnitude have been considered as test observables. The effects of catastrophic and parametric defects (bridges, opens and shorts) are analyzed in this work. Results show that by a right choice of the test observable, this technique provides high fault coverage levels even in the case of process variations.

  17. Hacking with Kali practical penetration testing techniques

    CERN Document Server

    Broad, James

    2013-01-01

    Hacking with Kali introduces you the most current distribution of the de facto standard tool for Linux pen testing. Starting with use of the Kali live CD and progressing through installation on hard drives, thumb drives and SD cards, author James Broad walks you through creating a custom version of the Kali live distribution. You'll learn how to configure networking components, storage devices and system services such as DHCP and web services. Once you're familiar with the basic components of the software, you'll learn how to use Kali through the phases of the penetration testing lifecycle

  18. Test-Taking Strategies of Arab EFL Learners on Multiple Choice Tests

    Science.gov (United States)

    Al Fraidan, Abdullah; Al-Khalaf, Khadija

    2012-01-01

    Many studies have focused on the function of learners' strategies in a variety of EFL domains. However, research on test-taking strategies (TTSs) has been limited, even though such strategies might influence test scores and, as a result, test validity. Motivated by this fact and in light of our own experience as EFL test-makers, this article will…

  19. Report on COTECH test procedure and characterization techniques

    DEFF Research Database (Denmark)

    Islam, Mohammad Aminul

    This deliverable report describes in detail the test steps that need to be executed in order to certify the final COTECH demonstrators for the specific application areas like health, biomedical, automotive, energy and information technology. It also defines and lists the capabilities and properties...... and material characterization techniques  Characterization techniques of the COTECH demonstrators  Functionality and lifecycle testing of the COTECH demonstrators Besides the general introduction and conclusion each section of the report is dedicated to the characterization techniques and test procedure.......Characterization techniques and test procedure requirements for innovative self-ligating dental brackets (EO) Section 5.Characterization techniques and test procedure requirements for smart diagnostic chips comprising a microfluidic channel system (GBO) Section 6.Characterization techniques and test procedure...

  20. Teaching TOEIC/TOEFL Test-Taking Strategies.

    Science.gov (United States)

    Forster, Douglas E.; Karn, Richard

    Teaching strategies are outlined for teachers of English as a second language to use in improving students' listening and reading comprehension skills specifically for two standardized tests: the Test of English for International Communication (TOEIC) and the Test of English as a Foreign Language (TOEFL). The strategies presented are not intended…

  1. EOR production technique tested on Codell

    Energy Technology Data Exchange (ETDEWEB)

    Stremel, K.

    1983-05-01

    A production method of natural gas that eliminated marketing problems and allowed maximum recovery was dicussed. The method involved the dehydration of the gas, stripping of the propane and butane products, and the compression and reinjection of the dry gas to the well. This maintenance of pressure will allow storage of the gas until marketing conditions improve. The production method is being tested at pilot wells in Colorado by Petromax Energy Corporation.

  2. Motivational and Cognitive Test-Taking Strategies and Their Influence on Test Performance in Mathematics

    Science.gov (United States)

    Peng, Yun; Hong, Eunsook; Mason, Elsa

    2014-01-01

    A structural equation model of relationships among testing-related motivation variables (test value, effort, self-efficacy, and test anxiety), test-taking strategies (test tactics and metacognitive strategies), gender, and math test performance were examined with a sample of 10th graders (N = 438; 182 males and 256 females). In general, motivation…

  3. Test-selection Strategies for Probabilistic Networks

    NARCIS (Netherlands)

    Sent, D.

    2005-01-01

    Decision-support systems are used in a large variety of domains. In the medical domain, such systems can be equipped with a patient-specific facility that indicates which diagnostic test or combination of tests should be performed. Current systems, however, do not take into account that tests might

  4. Testing microscopes between market and scientific strategies

    OpenAIRE

    Ratcliff, Marc

    2007-01-01

    This paper claims that the testing of microscopes during the eighteenth century reveals specific types of interaction between makers and users and links between scientific and economic interests. Basic procedures for the comparison and test of microscopes existed already in the Enlightenment although many historians thought that these were invented during the nineteenth century. The paper discusses three kinds of tests, advertising, the admission of a microscope in the laboratory, and finally...

  5. A TOTAL MANUFACTURING SOLUTIONS TECHNIQUE TO SELECT APPROPRIATE IMPROVEMENT STRATEGY: CASE STUDY OF A FOOTWEAR FACTORY

    Directory of Open Access Journals (Sweden)

    Gezahegn Tesfaye

    2014-09-01

    Full Text Available The Government of Ethiopia is promoting the manufacturing sector to join the global market in a large scale. Due to its comparative advantages, the Ethiopian leather and leather products industry have been given due attention. To fully utilize such advantages, the country shifted its export items from hides/skins to footwear products. Nevertheless, the performance of the leather sector in general and footwear sub-sector in particular is far below the desired standards. The improvement strategies applied hitherto were mainly to tackle a small portion of their total problems. If the Ethiopian footwear companies have to become globally competitive, their entire business spectrum has to be assessed and appropriate improvement strategies must be selected. In this research, we used a Total manufacturing solutions (TMS technique to identify areas of improvement and improvement strategy of one of Ethiopian footwear companies. For this purpose, we conducted two surveys using structured questionnaire. The first survey was to test the TMS technique against the context of footwear industry. The result proved that the original TMS model can be used to measure the performance of footwear companies. The second survey was done to identify company's total problems, map its current position and select appropriate improvement strategy. The result revealed that the company has company-wide problems and its current position is a plodder. For plodders which have company-wide problems, the improvement strategy must include aggressive application of BPR; and the implementation of best practices to develop workers skills that encourages networking and promotion, a market-led manufacturing strategy, employee involvement and team work cultures. According to the findings of this research, we suggested that a BPR technique followed by a continuous improvement programme could be an appropriate improvement strategy for this company. The company requires long-term improvement

  6. A strategy for skin irritation testing.

    Science.gov (United States)

    Robinson, Michael K; Perkins, Mary A

    2002-03-01

    Skin irritation safety testing and risk assessment for new products, and the ingredients they contain, is a critical requirement before market introduction. In the past, much of this skin testing required the use of experimental animals. However, new current best approaches for skin corrosion and skin irritation testing and risk assessment are being defined, obviating the need for animal test methods. Several in vitro skin corrosion test methods have been endorsed after successful validation and are gaining acceptance by regulatory authorities. In vitro test methods for acute, cumulative (repeat exposure), and chronic (prolonged exposure) skin irritation are under development. Though not yet validated, many are being used successfully for testing and risk assessment purposes as documented through an expanding literature. Likewise, a novel acute irritation patch test in human subjects is providing a valid and ethical alternative to animal testing for prediction of chemical skin irritation potential. An array of other human test methods also have been developed and used for the prediction of cumulative/chronic skin irritation and the general skin compatibility of finished products. The development of instrumental methods (e.g., transepidermal water loss, capacitance, and so on) has provided the means for analyzing various biophysical properties of human skin and changes in these properties caused by exposure to irritants. However, these methods do not directly measure skin inflammation. A recently introduced skin surface tape sampling procedure has been shown to detect changes in skin surface cytokine recovery that correlate with inflammatory skin changes associated with chemical irritant exposures or existing dermatitis. It holds promise for more objective quantification of skin irritation events, including subclinical (sensory) irritation, in the future.

  7. In-situ thermal testing program strategy

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-06-01

    In the past year the Yucca Mountain Site Characterization Project has implemented a new Program Approach to the licensing process. The Program Approach suggests a step-wise approach to licensing in which the early phases will require less site information than previously planned and necessitate a lesser degree of confidence in the longer-term performance of the repository. Under the Program Approach, the thermal test program is divided into two principal phases: (1) short-term in situ tests (in the 1996 to 2000 time period) and laboratory thermal tests to obtain preclosure information, parameters, and data along with bounding information for postclosure performance; and (2) longer-term in situ tests to obtain additional data regarding postclosure performance. This effort necessitates a rethinking of the testing program because the amount of information needed for the initial licensing phase is less than previously planned. This document proposes a revised and consolidated in situ thermal test program (including supporting laboratory tests) that is structured to meet the needs of the Program Approach. A customer-supplier model is used to define the Project data needs. These data needs, along with other requirements, were then used to define a set of conceptual experiments that will provide the required data within the constraints of the Program Approach schedule. The conceptual thermal tests presented in this document represent a consolidation and update of previously defined tests that should result in a more efficient use of Project resources. This document focuses on defining the requirements and tests needed to satisfy the goal of a successful license application in 2001, should the site be found suitable.

  8. Reading Test-taking Strategies in General Training IELTS

    Directory of Open Access Journals (Sweden)

    Vahede Nosrati

    2015-10-01

    Full Text Available The significance of gaining a better understanding of how test-taking strategies are used has been recognized by researchers. Considering this fact, this study aimed at investigating the test-taking strategies which were employed by IELTS candidates in reading comprehension test. Besides, it tried to take into account the differences among strategies used for different tasks. In order to gather data, two instruments were employed: the think-aloud protocol, and an IELTS reading test. The obtained data were analyzed and interpreted qualitatively by the researcher. The findings indicated that candidates employed 15 different strategies which were categorized in 3 stages, pre-reading, reading, and post-reading stages. Furthermore, it was revealed that test-takers used certain strategies differently, depending on the type of the task. The findings provide a better understanding of strategy use among IELTS candidates and help teachers to improve their approaches toward teaching and learning goals. Keywords: Test-taking Strategy, Test-taker, Reading Comprehension, Language Learning Strategy, IELTS

  9. Osteochondral tissue engineering with biphasic scaffold: current strategies and techniques.

    Science.gov (United States)

    Shimomura, Kazunori; Moriguchi, Yu; Murawski, Christopher D; Yoshikawa, Hideki; Nakamura, Norimasa

    2014-10-01

    The management of osteoarthritis (OA) remains challenging and controversial. Although several clinical options exist for the treatment of OA, regeneration of the damaged articular cartilage has proved difficult due to the limited healing capacity. With the advancements in tissue engineering and cell-based technologies over the past decade, new therapeutic options for patients with osteochondral lesions potentially exist. This review will focus on the feasibility of tissue-engineered biphasic scaffolds, which can mimic the native osteochondral complex, for osteochondral repair and highlight the recent development of these techniques toward tissue regeneration. Moreover, basic anatomy, strategy for osteochondral repair, the design and fabrication methods of scaffolds, as well as the choice of cells, growth factor, and materials will be discussed. Specifically, we focus on the latest preclinical animal studies using large animals and clinical trials with high clinical relevance. In turn, this will facilitate an understanding of the latest trends in osteochondral repair and contribute to the future application of such clinical therapies in patients with OA.

  10. Evaluating the effectiveness of training strategies: performance goals and testing.

    Science.gov (United States)

    Foshay, Wellesley R; Tinkey, Peggy T

    2007-01-01

    The Public Health Service policy, Animal Welfare Act regulations, and the Guide for the Care and Use of Laboratory Animals all require that institutions provide training for personnel engaged in animal research. Most research facilities have developed training programs to meet these requirements but may not have developed ways of assessing the effectiveness of these programs. Omission of this critical activity often leads to training that is ineffective, inefficient, or unnecessary. Evaluating the effectiveness of biomedical research and animal care training should involve a combination of assessments of performance, competence and knowledge, and appropriate tests for each type of knowledge, used at appropriate time intervals. In this article, the hierarchical relationship between performance, competence, and knowledge is described. The discussion of cognitive and psychomotor knowledge includes the important distinction between declarative and procedural knowledge. Measurement of performance is described and can include a variety of indirect and direct measurement techniques. Each measurement option has its own profile of strengths and weaknesses in terms of measurement validity, reliability, and costs of development and delivery. It is important to understand the tradeoffs associated with each measurement option, and to make appropriate choices of measurement strategy based on these tradeoffs arrayed against considerations of frequency, criticality, difficulty of learning, logistics, and budget. The article concludes with an example of how these measurement strategies can be combined into a cost-effective assessment plan for a biomedical research facility.

  11. Test-Taking Strategies. Research Brief

    Science.gov (United States)

    Walker, Karen

    2010-01-01

    Much has been written about student preparation for standardized tests such as: get enough sleep, do not eat sugary food or drinks, eat a well-balanced meal, wear comfortable clothing, bring appropriate supplies especially extra #2 pencils, answer every question, write neatly and legibly, deduce wrong answers immediately and use all of the time…

  12. Mutation Sampling Technique for the Generation of Structural Test Data

    CERN Document Server

    Scholive, M; Robach, C; Flottes, M L; Rouzeyre, B

    2011-01-01

    Our goal is to produce validation data that can be used as an efficient (pre) test set for structural stuck-at faults. In this paper, we detail an original test-oriented mutation sampling technique used for generating such data and we present a first evaluation on these validation data with regard to a structural test.

  13. STRATEGY/RESULT FOR SRF TEST INFRASTRUCTURES

    CERN Document Server

    Weingarten, W

    2011-01-01

    The report summarizes the requirements needed to further develop the technology of RF superconductivity for accelerator application beyond the present state of the art. In relation to emerging European accelerator projects present collaboration schemes are identified. The required test capacities are described and compared with the available ones. Based on a short historical review, the actual performance limits of superconducting cavities are evaluated and measures are proposed to overcome them.

  14. Ninja hacking unconventional penetration testing tactics and techniques

    CERN Document Server

    Wilhelm, Thomas

    2010-01-01

    Ever thought of using the time-tested tactics and techniques of the ancient ninja to understand the mind of today's ninja, the hacker? As a penetration tester or security consultant you no doubt perform tests both externally and internally for your clients that include both physical and technical tests. Throw traditional pen testing methods out the window for now and see how thinking and acting like a ninja can actually grant you quicker and more complete access to a company's assets. Get in before the hacker does with these unorthodox techniques. Use all of the tools that the ninja has: di

  15. Research on Digital Dynamic Testing Technique for Electrohydraulic Servovalve

    Institute of Scientific and Technical Information of China (English)

    汪首坤; 王军政; 赵江波; 张宇河

    2003-01-01

    The digital testing technique based on computers for dynamic characteristics of electrohydraulic servovalves via frequency scan method is researched. The no-load piston which measures the servo's transient output flow is designed properly. The velocity testing method by which the speed signal can be obtained indirectly by means of a piezoelectral accelerometer is given. High speed sampling has been realized in Windows OS. Wavelet denoising and Fourier transform are adopted in data processing and analyses. The testing technique discussed has been applied to actual testing systems and the experimental results have proved it to be correct.

  16. Marking Strategies in Metacognition-Evaluated Computer-Based Testing

    Science.gov (United States)

    Chen, Li-Ju; Ho, Rong-Guey; Yen, Yung-Chin

    2010-01-01

    This study aimed to explore the effects of marking and metacognition-evaluated feedback (MEF) in computer-based testing (CBT) on student performance and review behavior. Marking is a strategy, in which students place a question mark next to a test item to indicate an uncertain answer. The MEF provided students with feedback on test results…

  17. Data Mining Techniques Applied to Hydrogen Lactose Breath Test.

    Science.gov (United States)

    Rubio-Escudero, Cristina; Valverde-Fernández, Justo; Nepomuceno-Chamorro, Isabel; Pontes-Balanza, Beatriz; Hernández-Mendoza, Yoedusvany; Rodríguez-Herrera, Alfonso

    2017-01-01

    Analyze a set of data of hydrogen breath tests by use of data mining tools. Identify new patterns of H2 production. Hydrogen breath tests data sets as well as k-means clustering as the data mining technique to a dataset of 2571 patients. Six different patterns have been extracted upon analysis of the hydrogen breath test data. We have also shown the relevance of each of the samples taken throughout the test. Analysis of the hydrogen breath test data sets using data mining techniques has identified new patterns of hydrogen generation upon lactose absorption. We can see the potential of application of data mining techniques to clinical data sets. These results offer promising data for future research on the relations between gut microbiota produced hydrogen and its link to clinical symptoms.

  18. Strategy for Innovation in Soil Tests Illustrated for P Tests

    NARCIS (Netherlands)

    Reijneveld, A.; Termorshuizen, A.; Vedder, H.; Oenema, O.

    2014-01-01

    Soil phosphorus (P) tests are used for P fertilization recommendations, environmental evaluations, and occasionally for legislation purposes. The basis of fertilization recommendation as function of soil P status was established in the 1950s-1960s. Since then the agroeconomic environment has altered

  19. A Review of Scripting Techniques Used in Automated Software Testing

    Directory of Open Access Journals (Sweden)

    Milad Hanna

    2014-01-01

    Full Text Available Software testing is the process of evaluating the developed system to assess the quality of the final product. Unfortunately, software-testing process is expensive and consumes a lot of time through software development life cycle. As software systems grow, manual software testing becomes more and more difficult. Therefore, there was always a need to decrease the testing time. Recently, automation is as a major factor in reducing the testing effort by many researchers. Therefore, automating software-testing process is vital to its success. This study aims to compare the main features of different scripting techniques used in process of automating the execution phase in software testing process. In addition, an overview of different scripting techniques will be presented to show the state of art of this study.

  20. Defect detection in conducting materials using eddy current testing techniques

    Directory of Open Access Journals (Sweden)

    Brauer Hartmut

    2014-01-01

    Full Text Available Lorentz force eddy current testing (LET is a novel nondestructive testing technique which can be applied preferably to the identification of internal defects in nonmagnetic moving conductors. The LET is compared (similar testing conditions with the classical eddy current testing (ECT. Numerical FEM simulations have been performed to analyze the measurements as well as the identification of internal defects in nonmagnetic conductors. The results are compared with measurements to test the feasibility of defect identification. Finally, the use of LET measurements to estimate of the electrical conductors under test are described as well.

  1. Nondestructive testing by ESPI and quasi phase shift gradient technique

    Science.gov (United States)

    Pang, Linyong; Wu, Xiaoping

    1996-09-01

    A new nondestructive testing (NDT) technique, which is based on Electronic Speckle Pattern Interferometry (ESPI) and digital image processing with quasi phase shift and gradient technique, is presented. A simple phase reduction algorithm is developed, which replaced an accurate phase shifter. Compared with other phase shift techniques, this method is insensitive to environmental vibration and air disturbance, has visible procedures and results allows the object to move slowly during the inspection procedure, does not need phase unwrapping, and has a quick image processing speed. As an application, this NDT technique is used to detect defects in composite materials and the resulting deformation phase gradient image shows a better visual effect than normal ESPI.

  2. Strategies for cardiopulmonary exercise testing of pectus excavatum patients

    Directory of Open Access Journals (Sweden)

    Moh H. Malek

    2008-01-01

    Full Text Available The purpose of this paper is to provide strategies for cardiopulmonary exercise testing of pectus excavatum patients. Currently, there are no standardized methods for assessing cardiovascular and pulmonary responses in this population; therefore, making comparisons across studies is difficult if not impossible. These strategies are intended for physicians, pulmonary technicians, exercise physiologists, and other healthcare professionals who conduct cardiopulmonary exercise testing on pectus excavatum patients. By using the strategies outlined in this report, comparisons across studies can be made, and the effects of pectus excavatum on cardiopulmonary function can be assessed with greater detail.

  3. Twitch interpolation technique in testing of maximal muscle strength

    DEFF Research Database (Denmark)

    Bülow, P M; Nørregaard, J; Danneskiold-Samsøe, B

    1993-01-01

    The aim was to study the methodological aspects of the muscle twitch interpolation technique in estimating the maximal force of contraction in the quadriceps muscle utilizing commercial muscle testing equipment. Six healthy subjects participated in seven sets of experiments testing the effects on...

  4. Testing techniques for mechanical characterization of rapidly solidified materials

    Science.gov (United States)

    Koch, C. C.

    1986-01-01

    Mechanical property testing techniques are reviewed for rapidly solidified materials. Mechanical testing of rapidly solidified materials is complicated by the fact that in most cases at least one dimension of the material is very small (less than 100 microns). For some geometries, i.e., powder or thin surface layers, microhardness is the only feasible mechanical test. The ribbon geometry which is obtained by the melt-spinning method, however, has been used for a variety of mechanical property measurements including elastic properties, tensile properties, fracture toughness, creep, and fatigue. These techniques are described with emphasis placed on the precautions required by the restricted geometry of rapidly solidified specimens.

  5. PIE techniques for hydride reorientation test at NDC

    Energy Technology Data Exchange (ETDEWEB)

    Tsuda, Tomohiro; Shinohara, Yasunari; Yamaguchi, Yoichiro [Nuclear Development Corporation, Ibaraki (Japan)

    2008-11-15

    Dry storage of spent fuels in the interim storage facility is being planned in Japan. However, the gradual deterioration of the mechanical property of fuel cladding due to internal pressure and temperature during the storage term is known. Therefore, the integrity of stored fuel rods should be confirmed before the start of dry storage. For the last several years, NDC had a lot of experiences on the hydride reorientation test. The specimen preparation techniques on the hydride reorientation test and the mechanical testing techniques after the hydride reorientation are shown in this paper.

  6. A test of the domain-specific acculturation strategy hypothesis.

    Science.gov (United States)

    Miller, Matthew J; Yang, Minji; Lim, Robert H; Hui, Kayi; Choi, Na-Yeun; Fan, Xiaoyan; Lin, Li-Ling; Grome, Rebekah E; Farrell, Jerome A; Blackmon, Sha'kema

    2013-01-01

    Acculturation literature has evolved over the past several decades and has highlighted the dynamic ways in which individuals negotiate experiences in multiple cultural contexts. The present study extends this literature by testing M. J. Miller and R. H. Lim's (2010) domain-specific acculturation strategy hypothesis-that individuals might use different acculturation strategies (i.e., assimilated, bicultural, separated, and marginalized strategies; J. W. Berry, 2003) across behavioral and values domains-in 3 independent cluster analyses with Asian American participants. Present findings supported the domain-specific acculturation strategy hypothesis as 67% to 72% of participants from 3 independent samples using different strategies across behavioral and values domains. Consistent with theory, a number of acculturation strategy cluster group differences emerged across generational status, acculturative stress, mental health symptoms, and attitudes toward seeking professional psychological help. Study limitations and future directions for research are discussed.

  7. Non-Destructive Techniques Based on Eddy Current Testing

    Science.gov (United States)

    García-Martín, Javier; Gómez-Gil, Jaime; Vázquez-Sánchez, Ernesto

    2011-01-01

    Non-destructive techniques are used widely in the metal industry in order to control the quality of materials. Eddy current testing is one of the most extensively used non-destructive techniques for inspecting electrically conductive materials at very high speeds that does not require any contact between the test piece and the sensor. This paper includes an overview of the fundamentals and main variables of eddy current testing. It also describes the state-of-the-art sensors and modern techniques such as multi-frequency and pulsed systems. Recent advances in complex models towards solving crack-sensor interaction, developments in instrumentation due to advances in electronic devices, and the evolution of data processing suggest that eddy current testing systems will be increasingly used in the future. PMID:22163754

  8. Non-Destructive Techniques Based on Eddy Current Testing

    Directory of Open Access Journals (Sweden)

    Ernesto Vázquez-Sánchez

    2011-02-01

    Full Text Available Non-destructive techniques are used widely in the metal industry in order to control the quality of materials. Eddy current testing is one of the most extensively used non-destructive techniques for inspecting electrically conductive materials at very high speeds that does not require any contact between the test piece and the sensor. This paper includes an overview of the fundamentals and main variables of eddy current testing. It also describes the state-of-the-art sensors and modern techniques such as multi-frequency and pulsed systems. Recent advances in complex models towards solving crack-sensor interaction, developments in instrumentation due to advances in electronic devices, and the evolution of data processing suggest that eddy current testing systems will be increasingly used in the future.

  9. Non-destructive techniques based on eddy current testing.

    Science.gov (United States)

    García-Martín, Javier; Gómez-Gil, Jaime; Vázquez-Sánchez, Ernesto

    2011-01-01

    Non-destructive techniques are used widely in the metal industry in order to control the quality of materials. Eddy current testing is one of the most extensively used non-destructive techniques for inspecting electrically conductive materials at very high speeds that does not require any contact between the test piece and the sensor. This paper includes an overview of the fundamentals and main variables of eddy current testing. It also describes the state-of-the-art sensors and modern techniques such as multi-frequency and pulsed systems. Recent advances in complex models towards solving crack-sensor interaction, developments in instrumentation due to advances in electronic devices, and the evolution of data processing suggest that eddy current testing systems will be increasingly used in the future.

  10. A Comparative Study of White Box, Black Box and Grey Box Testing Techniques

    Directory of Open Access Journals (Sweden)

    Mohd. Ehmer Khan

    2012-06-01

    Full Text Available Software testing is the process to uncover requirement, design and coding errors in the program. It is used to identify the correctness, completeness, security and quality of software products against a specification. Software testing is the process used to measure the quality of developed computer software. It exhibits all mistakes, errors and flaws in the developed software. There are many approaches to software testing, but effective testing of complex product is essentially a process of investigation, not merely a matter of creating and following route procedure. It is not possible to find out all the errors in the program. This fundamental problem in testing thus throws an open question, as to what would be the strategy we should adopt for testing. In our paper, we have described and compared the three most prevalent and commonly used software testing techniques for detecting errors, they are: white box testing, black box testing and grey box testing.

  11. Towards an integrated in vitro strategy for estrogenicity testing

    NARCIS (Netherlands)

    Wang, S.; Aarts, H.J.M.; Haan, de L.H.J.; Argyriou, D.; Peijnenburg, A.A.C.M.; Rietjens, I.M.C.M.; Bovee, T.F.H.

    2014-01-01

    In order to define an in vitro integrated testing strategy (ITS) for estrogenicity, a set of 23 reference compounds representing diverse chemical classes were tested in a series of in vitro assays including proliferation and reporter gene assays. Outcomes of these assays were combined with published

  12. Data Mining Techniques Applied to Hydrogen Lactose Breath Test

    Science.gov (United States)

    Nepomuceno-Chamorro, Isabel; Pontes-Balanza, Beatriz; Hernández-Mendoza, Yoedusvany; Rodríguez-Herrera, Alfonso

    2017-01-01

    In this work, we present the results of applying data mining techniques to hydrogen breath test data. Disposal of H2 gas is of utmost relevance to maintain efficient microbial fermentation processes. Objectives Analyze a set of data of hydrogen breath tests by use of data mining tools. Identify new patterns of H2 production. Methods Hydrogen breath tests data sets as well as k-means clustering as the data mining technique to a dataset of 2571 patients. Results Six different patterns have been extracted upon analysis of the hydrogen breath test data. We have also shown the relevance of each of the samples taken throughout the test. Conclusions Analysis of the hydrogen breath test data sets using data mining techniques has identified new patterns of hydrogen generation upon lactose absorption. We can see the potential of application of data mining techniques to clinical data sets. These results offer promising data for future research on the relations between gut microbiota produced hydrogen and its link to clinical symptoms. PMID:28125620

  13. Optimizing Feedlot Diagnostic Testing Strategies Using Test Characteristics, Disease Prevalence, and Relative Costs of Misdiagnosis.

    Science.gov (United States)

    Theurer, Miles E; White, Brad J; Renter, David G

    2015-11-01

    Diagnostic tests are commonly used by feedlot practitioners and range from clinical observations to more advanced physiologic testing. Diagnostic sensitivity and specificity, estimated prevalence in the population, and the costs of misdiagnoses need to be considered when selecting a diagnostic test strategy and interpreting results. This article describes methods for evaluating diagnostic strategies using economic outcomes to evaluate the most appropriate strategy for the expected situation. The diagnostic sensitivity and specificity, and expected prevalence influence the likelihood of misdiagnosis in a given population, and the estimated direct economic impact can be used to quantify differences among diagnostic strategies.

  14. On Test-taking Strategies in Reading Test from Cognitive and Metacognitive Perspective

    Institute of Scientific and Technical Information of China (English)

    李欧

    2008-01-01

    Reading comprehension is a complex process wherein readers actively participate the activities of cognition, metatcognition and decoding information. In reading test, cognitive and metacognitive stategies always occur at the same time. Based on theories about learning strategies, this paper discusses test-taking strategies from a theoretical level.

  15. GMOtrack: generator of cost-effective GMO testing strategies.

    Science.gov (United States)

    Novak, Petra Krau; Gruden, Kristina; Morisset, Dany; Lavrac, Nada; Stebih, Dejan; Rotter, Ana; Zel, Jana

    2009-01-01

    Commercialization of numerous genetically modified organisms (GMOs) has already been approved worldwide, and several additional GMOs are in the approval process. Many countries have adopted legislation to deal with GMO-related issues such as food safety, environmental concerns, and consumers' right of choice, making GMO traceability a necessity. The growing extent of GMO testing makes it important to study optimal GMO detection and identification strategies. This paper formally defines the problem of routine laboratory-level GMO tracking as a cost optimization problem, thus proposing a shift from "the same strategy for all samples" to "sample-centered GMO testing strategies." An algorithm (GMOtrack) for finding optimal two-phase (screening-identification) testing strategies is proposed. The advantages of cost optimization with increasing GMO presence on the market are demonstrated, showing that optimization approaches to analytic GMO traceability can result in major cost reductions. The optimal testing strategies are laboratory-dependent, as the costs depend on prior probabilities of local GMO presence, which are exemplified on food and feed samples. The proposed GMOtrack approach, publicly available under the terms of the General Public License, can be extended to other domains where complex testing is involved, such as safety and quality assurance in the food supply chain.

  16. Strategy Development through Interview Technique from Narrative Therapy

    DEFF Research Database (Denmark)

    Kryger, Anders

    2017-01-01

    workshop, facilitated with interview technique from narrative therapy, and later authorized by the business area director. The organizational intervention preceded the scholarly inquiry. Findings: Employees’ retrospective storytelling about working at the company enabled them to formulate a joint mission...

  17. Recursive Algorithm and Alternate Operation Strategy in Sequential Tests

    Institute of Scientific and Technical Information of China (English)

    XU Hong-lin; CHEN Zhan-qi; GUO Lue

    2009-01-01

    Based on the sequential probability ratio test (SPRT) developed by Wald, an improved method for successful probability test of missile flight is proposed. A recursive algorithm and its program in Matlab are designed to calculate the real risk level of the sequential test decision and the average number of samples under various test conditions. A concept, that is "rejecting as soon as possible", is put forward and an alternate operation strategy is conducted. The simulation results show that it can reduce the test expenses.

  18. Data reproducibility of pace strategy in a laboratory test run

    Science.gov (United States)

    de França, Elias; Xavier, Ana Paula; Hirota, Vinicius Barroso; Côrrea, Sônia Cavalcanti; Caperuto, Érico Chagas

    2016-01-01

    This data paper contains data related to a reproducibility test for running pacing strategy in an intermittent running test until exhaustion. Ten participants underwent a crossover study (test and retest) with an intermittent running test. The test was composed of three-minute sets (at 1 km/h above Onset Blood Lactate Accumulation) until volitional exhaustion. To assess pace strategy change, in the first test participants chose the rest time interval (RTI) between sets (ranging from 30 to 60 s) and in the second test the maximum RTI values were either the RTI chosen in the first test (maximum RTI value), or less if desired. To verify the reproducibility of the test, rating perceived exertion (RPE), heart rate (HR) and blood plasma lactate concentration ([La]p) were collected at rest, immediately after each set and at the end of the tests. As results, RTI, RPE, HR, [La]p and time to exhaustion were not statistically different (p>0.05) between test and retest, as well as they demonstrated good intraclass correlation. PMID:27081672

  19. Test-Taking Strategies in L2 Assessment: The Test of English for International Communication Speaking Test.

    Science.gov (United States)

    Huang, Heng-Tsung Danny

    2016-08-01

    This research explored the test-taking strategies associated with the Test of English for International Communication Speaking Test (TOEIC-S) and their relationship with test performance. Capitalizing on two sets of TOEIC-S and a custom-made strategy inventory, the researcher collected data from a total of 215 Taiwanese English learners consisting of 84 males and 131 females with an average age of 20.1 years (SD = 2.6). Quantitative data analysis gave rise to three major findings. First, TOEIC-S test-taking strategy use constituted a multi-faceted construct that involved multiple types of strategic behaviors. Second, these strategic behaviors matched those allowing test-takers to communicate both in real life and in the workplace. Third, communication strategy use and cognitive strategy use both contributed significantly to TOEIC-S performance.

  20. Chapter 4: effective search strategies for systematic reviews of medical tests.

    Science.gov (United States)

    Relevo, Rose

    2012-06-01

    This article discusses techniques that are appropriate when developing search strategies for systematic reviews of medical tests. This includes general advice for searching for systematic reviews and issues specific to systematic reviews of medical tests. Diagnostic search filters are currently not sufficiently developed for use when searching for systematic reviews. Instead, authors should construct a highly sensitive search strategy that uses both controlled vocabulary and text words. A comprehensive search should include multiple databases and sources of grey literature. A list of subject-specific databases is included in this article.

  1. New Technique for Cryogenically Cooling Small Test Articles

    Science.gov (United States)

    Rodriquez, Karen M.; Henderson, Donald J.

    2011-01-01

    Convective heat removal techniques to rapidly cool small test articles to Earth-Moon L2 temperatures of 77 K were accomplished through the use of liquid nitrogen (LN2). By maintaining a selected pressure range on the saturation curve, test articles were cooled below the LN2 boiling point at ambient pressure in less than 30 min. Difficulties in achieving test pressures while maintaining the temperature tolerance necessitated a modification to the original system to include a closed loop conductive cold plate and cryogenic shroud

  2. Effective colonoscopy training techniques: strategies to improve patient outcomes

    Directory of Open Access Journals (Sweden)

    Papanikolaou IS

    2016-03-01

    Full Text Available Ioannis S Papanikolaou,1 Pantelis S Karatzas,2 Lazaros T Varytimiadis,2 Athanasios Tsigaridas,2 Michail Galanopoulos,2 Nikos Viazis,2 Dimitrios G Karamanolis21Hepato-gastroenterology Unit, 2nd Department of Internal Medicine, Attikon University General Hospital, University of Athens, 2Gastroenterology Department, Evangelismos Hospital, Athens, GreeceAbstract: Colonoscopy has substantially evolved during the last 20 years and many different training techniques have been developed in order to improve the performance of endoscopists. The most known are mechanical simulators, virtual reality simulators, computer-simulating endoscopy, magnetic endoscopic imaging, and composite and explanted animal organ simulators. Current literature generally indicates that the use of simulators improves performance of endoscopists and enhances safety of patients, especially during the initial phase of training. Moreover, newer endoscopes and imaging techniques such as high-definition colonoscopes, chromocolonoscopy with dyes spraying, and third-eye retroscope have been incorporated in everyday practice, offering better visualization of the colon and detection of polyps. Despite the abundance of these different technological features, training devices are not widely used and no official guideline or specified training algorithm or technique for lower gastrointestinal endoscopy has been evolved. In this review, we present the most important training methods currently available and evaluate these using existing literature. We also try to propose a training algorithm for novice endoscopists.Keywords: endoscopy, colonoscopy, teaching techniques, simulator, endoscopists, colon, polyps

  3. An Effective Strategy to Build Up a Balanced Test Suite for Spectrum-Based Fault Localization

    Directory of Open Access Journals (Sweden)

    Ning Li

    2016-01-01

    Full Text Available During past decades, many automated software faults diagnosis techniques including Spectrum-Based Fault Localization (SBFL have been proposed to improve the efficiency of software debugging activity. In the field of SBFL, suspiciousness calculation is closely related to the number of failed and passed test cases. Studies have shown that the ratio of the number of failed and passed test case has more significant impact on the accuracy of SBFL than the total number of test cases, and a balanced test suite is more beneficial to improving the accuracy of SBFL. Based on theoretical analysis, we proposed an PNF (Passed test cases, Not execute Faulty statement strategy to reduce test suite and build up a more balanced one for SBFL, which can be used in regression testing. We evaluated the strategy making experiments using the Siemens program and Space program. Experiments indicated that our PNF strategy can be used to construct a new test suite effectively. Compared with the original test suite, the new one has smaller size (average 90% test case was reduced in experiments and more balanced ratio of failed test cases to passed test cases, while it has the same statement coverage and fault localization accuracy.

  4. REGRESSION TESTING : TABU SEARCH TECHNIQUE FOR CODE COVERAGE

    Directory of Open Access Journals (Sweden)

    T.Prem Jacob

    2013-07-01

    Full Text Available Software testing is one of the most expensive and critical activities which carries out every time in order to give a best quality of a software product. Here the regression testing which is based on testing mechanism is used to analyze the source code changes and also to make sure that the changes that does not establish new bugs in theearlier validated codes. Now a days many innovative methods are raised in performing the software testing, among them the unit testing which uses minimum time frame and gives more effort in performing a task. Under lots of schedule the unit testing mechanism is done by more developers as the software companies has an enough time to find cooperation among different operations like functionality, quality and time to market. There is an essential to reduce the unit testing time by making it as an automated one and also by making its process as more optimistic.Here, this paper propose a technique called Tabu search based technique for an effective code coverage to cyclomatic complexity which is used to measure the complexity of a program.

  5. Listening strategy use, test anxiety and test performance of intermediate and advanced Iranian EFL learners

    Directory of Open Access Journals (Sweden)

    Raoof Hamzavi

    2014-08-01

    Full Text Available Learning a foreign language has been related with some kind of strategic knowledge on the one hand, and some level of (test-taking apprehension or tension on the other hand, although a small amount of anxiety is normally expected as a natural warning symptom. The current study aimed at investigating the relationship between listening strategy use, test anxiety, and listening test performance of Iranian intermediate and advanced EFL learners. To this end, eighty (40 intermediate and 40 advanced Iranian EFL learners took part in the study by completing Lee’s (1997 Listening Comprehension Strategy Questionnaire, Sarason’s (1975 Test Anxiety Scale (TAS, and two monologues of Listening test performance selected from Listening part of TOEFL. The results of Pearson product moment correlation analyses revealed a significant negative correlation between test anxiety and listening test performance, but a significant positive association between listening strategy use and listening test performance. Furthermore, the results of multiple regression analyses indicated listening strategy use was a stronger predictor of listening test performance. Additionally, the results of independent samples t-test showed a significant difference between Iranian intermediate and advanced EFL learners regarding both their listening strategy use and level of test anxiety.

  6. Power-aware testing and test strategies for low power devices

    CERN Document Server

    Girard, Patrick; Wen, Xiaoqing

    2010-01-01

    Power-aware testing methods for conventional circuits and systems are explored in this volume, while providing safe testing techniques without compromising reliability. State-of-the-art industrial practices are discusses, as well as EDA solutions.

  7. A speedup technique for dynamic graphs using partitioning strategy and multithreaded approach

    Directory of Open Access Journals (Sweden)

    R. Kalpana

    2014-01-01

    Full Text Available There are many pre-processing-based speedup techniques for shortest path problems that are available in the literature. These techniques have an increased demand because of large datasets in such applications such as roadmaps, web search engines and mobile data sets. Pre-processing for the Time-Dependent Shortest Path Problem is still a demanding process that involves graph or network partitioning strategy. Efficient pre-processing of graphs or networks reduces the shortest path computation time while parallelizing the pre-processing phase improves the speedup of the system. In this paper, a speedup technique called Recursive Spectral Bisection (RSB combined with the Elliptic Convolution of the shortest path method is proposed for dynamic Time-Dependent networks. The same method has been parallelized, and the results are tested on three types of graphs. It is observed that the Time-Dependent RSB combined with the Elliptic Convolution of the shortest path method has no update time, and the Query Performance Loss (QPL is reduced in planar and road networks compared to random networks. In road networks, the proposed method achieves an average speedup in a QPL of 140. The use of the Parallel speedup technique results in an average speedup in a QPL of more than 1 in the planar and road networks.

  8. Nonpharmacological, Blood Conservation Techniques for Preventing Neonatal Anemia—Effective and Promising Strategies for Reducing Transfusion

    Science.gov (United States)

    Carroll, Patrick D.; Widness, John A.

    2012-01-01

    The development of anemia after birth in very premature, critically ill newborn infants is a universal well-described phenomenon. Although preventing anemia in this population, along with efforts to establish optimal red blood cell (RBC) transfusion and pharmacologic therapy continue to be actively investigated, the present review focuses exclusively on nonpharmacological approaches to the prevention and treatment of neonatal anemia. We begin with an overview of topics relevant to nonpharmacological techniques. These topics include neonatal and fetoplacental hemoglobin levels and blood volumes, clinical and laboratory practices applied in critically ill neonates, and current RBC transfusion practice guidelines. This is followed by a discussion of the most effective and promising nonpharmacological blood conservation strategies and techniques. Fortunately, many of these techniques are feasible in most neonatal intensive care units. When applied together, these techniques are more effective than existing pharmacotherapies in significantly decreasing neonatal RBC transfusions. They include increasing hemoglobin endowment and circulating blood volume at birth; removing less blood for laboratory testing; and optimizing nutrition. PMID:22818543

  9. Nonpharmacological, blood conservation techniques for preventing neonatal anemia--effective and promising strategies for reducing transfusion.

    Science.gov (United States)

    Carroll, Patrick D; Widness, John A

    2012-08-01

    The development of anemia after birth in very premature, critically ill newborn infants is a universal well-described phenomenon. Although preventing anemia in this population, along with efforts to establish optimal red blood cell (RBC) transfusion and pharmacologic therapy continue to be actively investigated, the present review focuses exclusively on nonpharmacological approaches to the prevention and treatment of neonatal anemia. We begin with an overview of topics relevant to nonpharmacological techniques. These topics include neonatal and fetoplacental hemoglobin levels and blood volumes, clinical and laboratory practices applied in critically ill neonates, and current RBC transfusion practice guidelines. This is followed by a discussion of the most effective and promising nonpharmacological blood conservation strategies and techniques. Fortunately, many of these techniques are feasible in most neonatal intensive care units. When applied together, these techniques are more effective than existing pharmacotherapies in significantly decreasing neonatal RBC transfusions. They include increasing hemoglobin endowment and circulating blood volume at birth; removing less blood for laboratory testing; and optimizing nutrition. Copyright © 2012 Elsevier Inc. All rights reserved.

  10. A Method to Test Model Calibration Techniques: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Judkoff, Ron; Polly, Ben; Neymark, Joel

    2016-09-01

    This paper describes a method for testing model calibration techniques. Calibration is commonly used in conjunction with energy retrofit audit models. An audit is conducted to gather information about the building needed to assemble an input file for a building energy modeling tool. A calibration technique is used to reconcile model predictions with utility data, and then the 'calibrated model' is used to predict energy savings from a variety of retrofit measures and combinations thereof. Current standards and guidelines such as BPI-2400 and ASHRAE-14 set criteria for 'goodness of fit' and assume that if the criteria are met, then the calibration technique is acceptable. While it is logical to use the actual performance data of the building to tune the model, it is not certain that a good fit will result in a model that better predicts post-retrofit energy savings. Therefore, the basic idea here is that the simulation program (intended for use with the calibration technique) is used to generate surrogate utility bill data and retrofit energy savings data against which the calibration technique can be tested. This provides three figures of merit for testing a calibration technique, 1) accuracy of the post-retrofit energy savings prediction, 2) closure on the 'true' input parameter values, and 3) goodness of fit to the utility bill data. The paper will also discuss the pros and cons of using this synthetic surrogate data approach versus trying to use real data sets of actual buildings.

  11. HyRAM Testing Strategy and Quality Design Elements.

    Energy Technology Data Exchange (ETDEWEB)

    Reynolds, John Thomas

    2014-12-01

    Strategy document and tentative schedule for testing of HyRAM, a software toolkit that integrates data and methods relevant to assessing the safety of hydrogen fueling and storage infrastructure. Because proposed and existing features in HyRAM that support testing are important factors in this discussion, relevant design considerations of HyRAM are also discussed. However, t his document does not cover all of HyRAM desig n, nor is the full HyRAM software development schedule included.

  12. Curriculum and Testing Strategies to Maximize Special Education STAAR Achievement

    Science.gov (United States)

    Johnson, William L.; Johnson, Annabel M.; Johnson, Jared W.

    2015-01-01

    This document is from a presentation at the 2015 annual conference of the Science Teachers Association of Texas (STAT). The two sessions (each listed as feature sessions at the state conference) examined classroom strategies the presenter used in his chemistry classes to maximize Texas end-of-course chemistry test scores for his special population…

  13. Power electronic converters PWM strategies and current control techniques

    CERN Document Server

    Monmasson, Eric

    2013-01-01

    A voltage converter changes the voltage of an electrical power source and is usually combined with other components to create a power supply. This title is devoted to the control of static converters, which deals with pulse-width modulation (PWM) techniques, and also discusses methods for current control. Various application cases are treated. The book is ideal for professionals in power engineering, power electronics, and electric drives industries, as well as practicing engineers, university professors, postdoctoral fellows, and graduate students.

  14. Effective colonoscopy training techniques: strategies to improve patient outcomes

    OpenAIRE

    Papanikolaou IS; Karatzas PS; Varytimiadis LT; Tsigaridas A; Galanopoulos M; Viazis N; Karamanolis DG

    2016-01-01

    Ioannis S Papanikolaou,1 Pantelis S Karatzas,2 Lazaros T Varytimiadis,2 Athanasios Tsigaridas,2 Michail Galanopoulos,2 Nikos Viazis,2 Dimitrios G Karamanolis21Hepato-gastroenterology Unit, 2nd Department of Internal Medicine, Attikon University General Hospital, University of Athens, 2Gastroenterology Department, Evangelismos Hospital, Athens, GreeceAbstract: Colonoscopy has substantially evolved during the last 20 years and many different training techniques have been developed in order to i...

  15. Effective colonoscopy training techniques: strategies to improve patient outcomes.

    Science.gov (United States)

    Papanikolaou, Ioannis S; Karatzas, Pantelis S; Varytimiadis, Lazaros T; Tsigaridas, Athanasios; Galanopoulos, Michail; Viazis, Nikos; Karamanolis, Dimitrios G

    2016-01-01

    Colonoscopy has substantially evolved during the last 20 years and many different training techniques have been developed in order to improve the performance of endoscopists. The most known are mechanical simulators, virtual reality simulators, computer-simulating endoscopy, magnetic endoscopic imaging, and composite and explanted animal organ simulators. Current literature generally indicates that the use of simulators improves performance of endoscopists and enhances safety of patients, especially during the initial phase of training. Moreover, newer endoscopes and imaging techniques such as high-definition colonoscopes, chromocolonoscopy with dyes spraying, and third-eye retroscope have been incorporated in everyday practice, offering better visualization of the colon and detection of polyps. Despite the abundance of these different technological features, training devices are not widely used and no official guideline or specified training algorithm or technique for lower gastrointestinal endoscopy has been evolved. In this review, we present the most important training methods currently available and evaluate these using existing literature. We also try to propose a training algorithm for novice endoscopists.

  16. Efficient Testing Combing Design of Experiment and Learn-to-Fly Strategies

    Science.gov (United States)

    Murphy, Patrick C.; Brandon, Jay M.

    2017-01-01

    Rapid modeling and efficient testing methods are important in a number of aerospace applications. In this study efficient testing strategies were evaluated in a wind tunnel test environment and combined to suggest a promising approach for both ground-based and flight-based experiments. Benefits of using Design of Experiment techniques, well established in scientific, military, and manufacturing applications are evaluated in combination with newly developing methods for global nonlinear modeling. The nonlinear modeling methods, referred to as Learn-to-Fly methods, utilize fuzzy logic and multivariate orthogonal function techniques that have been successfully demonstrated in flight test. The blended approach presented has a focus on experiment design and identifies a sequential testing process with clearly defined completion metrics that produce increased testing efficiency.

  17. Advances in Testing Techniques for Digital Microfluidic Biochips

    Science.gov (United States)

    Shukla, Vineeta; Hussin, Fawnizu Azmadi; Hamid, Nor Hisham; Zain Ali, Noohul Basheer

    2017-01-01

    With the advancement of digital microfluidics technology, applications such as on-chip DNA analysis, point of care diagnosis and automated drug discovery are common nowadays. The use of Digital Microfluidics Biochips (DMFBs) in disease assessment and recognition of target molecules had become popular during the past few years. The reliability of these DMFBs is crucial when they are used in various medical applications. Errors found in these biochips are mainly due to the defects developed during droplet manipulation, chip degradation and inaccuracies in the bio-assay experiments. The recently proposed Micro-electrode-dot Array (MEDA)-based DMFBs involve both fluidic and electronic domains in the micro-electrode cell. Thus, the testing techniques for these biochips should be revised in order to ensure proper functionality. This paper describes recent advances in the testing technologies for digital microfluidics biochips, which would serve as a useful platform for developing revised/new testing techniques for MEDA-based biochips. Therefore, the relevancy of these techniques with respect to testing of MEDA-based biochips is analyzed in order to exploit the full potential of these biochips. PMID:28749411

  18. Advances in Testing Techniques for Digital Microfluidic Biochips

    Directory of Open Access Journals (Sweden)

    Vineeta Shukla

    2017-07-01

    Full Text Available With the advancement of digital microfluidics technology, applications such as on-chip DNA analysis, point of care diagnosis and automated drug discovery are common nowadays. The use of Digital Microfluidics Biochips (DMFBs in disease assessment and recognition of target molecules had become popular during the past few years. The reliability of these DMFBs is crucial when they are used in various medical applications. Errors found in these biochips are mainly due to the defects developed during droplet manipulation, chip degradation and inaccuracies in the bio-assay experiments. The recently proposed Micro-electrode-dot Array (MEDA-based DMFBs involve both fluidic and electronic domains in the micro-electrode cell. Thus, the testing techniques for these biochips should be revised in order to ensure proper functionality. This paper describes recent advances in the testing technologies for digital microfluidics biochips, which would serve as a useful platform for developing revised/new testing techniques for MEDA-based biochips. Therefore, the relevancy of these techniques with respect to testing of MEDA-based biochips is analyzed in order to exploit the full potential of these biochips.

  19. An alternative strategy to western blot as a confirmatory diagnostic test for HIV infection.

    Science.gov (United States)

    Feng, Xia; Wang, Jibao; Gao, Zhiyun; Tian, Yu; Zhang, Ling; Chen, Huichao; Zhang, Tong; Xiao, Lin; Yao, Jun; Xing, Wenge; Qiu, Maofeng; Jiang, Yan

    2017-03-01

    In China, western blot (WB) is the recommended procedure for the diagnosis of HIV infection. However, this technique is time consuming and labor intensive, and its complexity restricts wide application in resource-limited regions. The aim of this study was to evaluate the efficacy of a dry blood spots (DBS)-urine paired enzyme-linked immunosorbent assay (ELISA) test, instead of WB, for HIV antibody detection. Plasma, DBS, and urine samples were collected from 1213 subjects from different populations. Two diagnostic testing strategies were conducted in parallel. The equivalence of the paired ELISA and WB strategies was assessed. A diagnosis of HIV was determined in 250 subjects according to the paired ELISA test, and in 249 according to the WB strategy. The discordant case was judged HIV-positive during follow-up. In total, 18 subjects were diagnosed with possible HIV using the paired ELISA test, among whom, 11 subjects tested negative with WB, and one was confirmed to be HIV-positive during follow-up. For the remaining 945 subjects, both strategies indicated a negative result. The kappa test indicated good conformity (kappa=0.954) between the two diagnostic strategies. The DBS-urine paired ELISA could be applied as an alternative to WB in HIV diagnosis, which would be valuable in resource-limited regions owing to the associated affordability and ease of use. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

  20. Large Field Photogrammetry Techniques in Aircraft and Spacecraft Impact Testing

    Science.gov (United States)

    Littell, Justin D.

    2010-01-01

    The Landing and Impact Research Facility (LandIR) at NASA Langley Research Center is a 240 ft. high A-frame structure which is used for full-scale crash testing of aircraft and rotorcraft vehicles. Because the LandIR provides a unique capability to introduce impact velocities in the forward and vertical directions, it is also serving as the facility for landing tests on full-scale and sub-scale Orion spacecraft mass simulators. Recently, a three-dimensional photogrammetry system was acquired to assist with the gathering of vehicle flight data before, throughout and after the impact. This data provides the basis for the post-test analysis and data reduction. Experimental setups for pendulum swing tests on vehicles having both forward and vertical velocities can extend to 50 x 50 x 50 foot cubes, while weather, vehicle geometry, and other constraints make each experimental setup unique to each test. This paper will discuss the specific calibration techniques for large fields of views, camera and lens selection, data processing, as well as best practice techniques learned from using the large field of view photogrammetry on a multitude of crash and landing test scenarios unique to the LandIR.

  1. Fatigue testing of three peristernal median sternotomy closure techniques

    Directory of Open Access Journals (Sweden)

    Griffin Lanny V

    2008-09-01

    Full Text Available Abstract Background Failure of a sternotomy closure because of closure system fatigue is a complication that may result in dehiscence and put the individual at risk for serious complications. The purpose of this study was to assess the fatigue performance of three peristernal median sternotomy closure techniques (figure-of-eight stainless-steel wires, figure-of-eight stainless-steel cables, or Pectofix Dynamic Sternal Fixation [DSF] stainless-steel plates in order to quantify the potential risk of fatigue failure of these devices when subject to cyclic loads in physiologically relevant loading directions. Study Design All tests were conducted on polyurethane foam sternal models. A cardiothoracic surgeon divided each sternal model longitudinally and repaired it with a closure device. Tests were performed using a materials testing system that applied cyclic loading in a uniaxial direction until the test model catastrophically broke or data run-out occurred. For each loading direction (lateral distraction and longitudinal shear, five trials of each closure technique were tested. Life data and location of device failure (if present were evaluated. Statistical analysis was performed using regression with life data allowed for correlation between life data and the various closure techniques to develop risk assessment curves for each device. Results The data show that the figure-of-eight stainless-steel cable and the DSF plate systems are considerably less likely to fail under both lateral distraction and longitudinal shear cyclic loading conditions as compared to the figure-of-eight stainless-steel wire system. Moreover, the figure-of-eight stainless-steel cable system is the most resistant to failure, particularly for high cycle counts. Conclusion This study in addition to Cohen and Griffin's earlier published biomechanical comparison of the ultimate strength of these same three closure techniques provide extensive experimental evidence regarding the

  2. Strategies and techniques of communication and public relations applied to non-profit sector

    Directory of Open Access Journals (Sweden)

    Ioana – Julieta Josan

    2010-05-01

    Full Text Available The aim of this paper is to summarize the strategies and techniques of communication and public relations applied to non-profit sector.The approach of the paper is to identify the most appropriate strategies and techniques that non-profit sector can use to accomplish its objectives, to highlight specific differences between the strategies and techniques of the profit and non-profit sectors and to identify potential communication and public relations actions in order to increase visibility among target audience, create brand awareness and to change into positive brand sentiment the target perception about the non-profit sector.

  3. Neutron capture strategy and technique developments for GNEP

    Energy Technology Data Exchange (ETDEWEB)

    Couture, Aaron Joseph [Los Alamos National Laboratory

    2008-01-01

    The initial three years of neutron capture measurements have been very successful in providing data for the Advanced Fuel Cycle Initiative/Global Nuclear Energy Partnership (AFCI/GNEP) program. Now that the most straightforward measurements have been completed, additional technical challenges face future measurements. In particular, techniques are needed to perform measurements that exhibit at least one of three major problems -- large fission:capture ratios, large capture:capture ratios, and high intrinsic activity samples. This paper will set forward a plan for attacking these technical challenges and moving forward with future measurements.

  4. Test-taking Strategies & Performance on Reading Comprehension Tests by Iranian EFL Learners

    Directory of Open Access Journals (Sweden)

    Natasha Pourdana

    2012-07-01

    Full Text Available This study attempted to explore the possible relationship between test-taking strategies and (a successful performance on English as a Foreign Language (EFL reading comprehension, (b EFL learners’ level of language proficiency. To accomplish the purpose of this study, 68 students of English translation of both genders were randomly selected and placed in the three Beginner, Intermediate and Advanced levels, at Alborz Institute for Higher Education, Qazvin, Iran. Analysis of Variances (ANOVA proved that there was a significant and positive correlation between the scores in reading comprehension test and Oxford Placement Test. While the scores in reading comprehension test did not show any significant correlations with using the majority of test-taking strategies, they had a relatively low and negative but significant correlation with test management strategy. The findings in this study were interpreted as the low knowledge of test-taking strategies in Iranian EFL context and the importance of attending to the cognitive processes effective in taking language tests was emphasized.  Keywords: Test-taking, Strategies, EFL, Reading Comprehension, Proficiency level

  5. Hypothesis testing in students: Sequences, stages, and instructional strategies

    Science.gov (United States)

    Moshman, David; Thompson, Pat A.

    Six sequences in the development of hypothesis-testing conceptions are proposed, involving (a) interpretation of the hypothesis; (b) the distinction between using theories and testing theories; (c) the consideration of multiple possibilities; (d) the relation of theory and data; (e) the nature of verification and falsification; and (f) the relation of truth and falsity. An alternative account is then provided involving three global stages: concrete operations, formal operations, and a postformal metaconstructivestage. Relative advantages and difficulties of the stage and sequence conceptualizations are discussed. Finally, three families of teaching strategy are distinguished, which emphasize, respectively: (a) social transmission of knowledge; (b) carefully sequenced empirical experience by the student; and (c) self-regulated cognitive activity of the student. It is argued on the basis of Piaget's theory that the last of these plays a crucial role in the construction of such logical reasoning strategies as those involved in testing hypotheses.

  6. Comparison of different experimental techniques used for wax deposition testing

    Energy Technology Data Exchange (ETDEWEB)

    Allenson, Stephen; Johnston, Angela [Nalco Energy Services, Sugar Land, TX (United States)

    2008-07-01

    Crude oils consist of various fractions of hydrocarbons, including n-paraffins. The paraffins precipitate out of oil below the temperature called WAT (wax appearance temperature) and accumulate in flow lines and pipelines causing major transport problems. Prediction of paraffin deposition is, therefore, a key element of flow assurance programs. The purpose of this study was to develop a general and reliable approach to prediction of wax deposition based on a critical comparison of several practical lab techniques. Wax deposition study was conducted on five separate crude oils by using a varying protocols and equipment. One experimental technique was a cold stress test of wax deposition combined with ketone precipitation of waxy paraffin crystals. Another set of experiments were carried out for wax deposits formed on the surface of U-tubes and cold fingers of different designs. A comparison of the effectiveness of several wax inhibitors was conducted for these crude oils by using the selected deposition techniques. In each test method the amount of precipitated wax was recorded and compared. The deposits were characterized by melting point, qualitative and quantitative analysis of the wax components using DSC, SARA and HTGC analyses. Efficiency of paraffin inhibitors was correlated with a profile of n-paraffins distribution in the deposits. The limitations and advantages of different deposition techniques were analyzed and discussed. (author)

  7. Test strategies for industrial testers for converter controls equipment

    Science.gov (United States)

    Oleniuk, P.; Di Cosmo, M.; Kasampalis, V.; Nisbet, D.; Todd, B.; Uznański, S.

    2017-04-01

    Power converters and their controls electronics are key elements for the operation of the CERN accelerator complex, having a direct impact on its availability. To prevent early-life failures and provide means to verify electronics, a set of industrial testers is used throughout the converters controls electronics' life cycle. The roles of the testers are to validate mass production during the manufacturing phase and to provide means to diagnose and repair failed modules that are brought back from operation. In the converter controls electronics section of the power converters group in the technology department of CERN (TE/EPC/CCE), two main test platforms have been adopted: a PXI platform for mixed analogue-digital functional tests and a JTAG Boundary-Scan platform for digital interconnection and functional tests. Depending on the functionality of the device under test, the appropriate test platforms are chosen. This paper is a follow-up to results presented at the TWEPP 2015 conference, adding the boundary scan test platform and the first results from exploitation of the test system. This paper reports on the test software, hardware design and test strategy applied for a number of devices that has resulted in maximizing test coverage and minimizing test design effort.

  8. Collaborative testing as a learning strategy in nursing education.

    Science.gov (United States)

    Sandahl, Sheryl S

    2010-01-01

    A primary goal of nursing education is to prepare nurses to work collaboratively as members of interprofessional health care teams on behalf of patients. Collaborative testing is a collaborative learning strategy used to foster knowledge development, critical thinking in decision making, and group processing skills. This study incorporated a quasi-experimental design with a comparison group to examine the effect of collaborative testing as a learning strategy on student learning and retention of course content as well as group process skills and student perceptions of their learning and anxiety. The setting was a baccalaureate nursing program; the sample consisted of two groups of senior students enrolled in Medical-Surgical Nursing II. Student learning, as measured by unit examination scores, was greater for students taking examinations collaboratively compared to individually. Retention of course content, as measured by final examination scores, was not greater for students taking examinations collaboratively compared to individually. Student perceptions were overwhelmingly positive, with students reporting increased learning as a result of the collaborative testing experiences. Despite the lack of data to support increased retention, collaborative testing may be a learning strategy worth implementing in nursing education. Students reported more positive interactions and collaboration with their peers, skills required by the professional nurse.

  9. FACTORS AFFECTING RESULT IN CHINESE PROFICIENCY TEST (HSK LEVEL 6: READING SECTION AND PREPARATION STRATEGIES

    Directory of Open Access Journals (Sweden)

    Sri Haryanti

    2013-11-01

    Full Text Available Chinese Proficiency Test (HSK is an internationally standardized exam which tests and rates Chinese language proficiency. The highest level in this test is level 6. The writing part of the test consists of 3 (three parts, namely, (1 listening, (2 reading, (3 writing. Furthermore, the reading part is made of 4 components. Level 6 of this test implies a high degree of difficulty. This paper specifically looked on how to prepare effectively for participants to be able to work on the reading part in order to achieve best result. This article used the methods of literature review and observational study as well as field research and would also incorporate the author’s personal experience in taking the test into recommending strategies for doing the reading part in a level 6 HSK test. Finally, research suggested several techniques and tips that might assist participants in achieving maximum scores in handling the reading part of level 6 HSK test.

  10. FACTORS AFFECTING RESULT IN CHINESE PROFICIENCY TEST (HSK LEVEL 6 READING SECTION AND PREPARATION STRATEGIES

    Directory of Open Access Journals (Sweden)

    Sri Haryanti

    2015-02-01

    Full Text Available Chinese proficiency test (HSK is an internationally standardized exam which tests and rates Chinese language proficiency. The highest level in this test is level 6. The writing part of the test consists of 3 (three parts, namely, (1 listening, (2 reading, (3 writing. Furthermore, the reading part is made of 4 components. Level 6 of this test implies a high degree of difficulty. This paper specifically looked on how to prepare effectively for participants to be able to work on the reading part in order to achieve best result. This article used the methods of literature review and observational study as well as field research and would also incorporate the authors personal experience in taking the test into recommending strategies for doing the reading part in a level 6 HSK test. Finally, research suggested several techniques and tips that might assist participants in achieving maximum scores in handling the reading part of level 6 HSK test.

  11. Towards an alternative testing strategy for nanomaterials used in nanomedicine

    DEFF Research Database (Denmark)

    Dusinska, M; Boland, S; Saunders, M

    2015-01-01

    project ( www.nanotest-fp7.eu ) was a better understanding of mechanisms of interactions of NPs employed in nanomedicine with cells, tissues and organs and to address critical issues relating to toxicity testing especially with respect to alternatives to tests on animals. Here we describe an approach...... towards alternative testing strategies for hazard and risk assessment of nanomaterials, highlighting the adaptation of standard methods demanded by the special physicochemical features of nanomaterials and bioavailability studies. The work has assessed a broad range of toxicity tests, cell models and NP...... of scientists, politicians and the public about potential health hazards associated with NPs need to be answered. With the variety of exposure routes available, there is potential for NPs to reach every organ in the body but we know little about the impact this might have. The main objective of the FP7 NanoTEST...

  12. TESTING DIFFERENT SURVEY TECHNIQUES TO MODEL ARCHITECTONIC NARROW SPACES

    Directory of Open Access Journals (Sweden)

    A. Mandelli

    2017-08-01

    Full Text Available In the architectural survey field, there has been the spread of a vast number of automated techniques. However, it is important to underline the gap that exists between the technical specification sheet of a particular instrument and its usability, accuracy and level of automation reachable in real cases scenario, especially speaking about Cultural Heritage (CH field. In fact, even if the technical specifications (range, accuracy and field of view are known for each instrument, their functioning and features are influenced by the environment, shape and materials of the object. The results depend more on how techniques are employed than the nominal specifications of the instruments. The aim of this article is to evaluate the real usability, for the 1:50 architectonic restitution scale, of common and not so common survey techniques applied to the complex scenario of dark, intricate and narrow spaces such as service areas, corridors and stairs of Milan’s cathedral indoors. Tests have shown that the quality of the results is strongly affected by side-issues like the impossibility of following the theoretical ideal methodology when survey such spaces. The tested instruments are: the laser scanner Leica C10, the GeoSLAM ZEB1, the DOT DPI 8 and two photogrammetric setups, a full frame camera with a fisheye lens and the NCTech iSTAR, a panoramic camera. Each instrument presents advantages and limits concerning both the sensors themselves and the acquisition phase.

  13. Learning Techniques for Automatic Test Pattern Generation using Boolean Satisfiability

    Directory of Open Access Journals (Sweden)

    Liu Xin

    2013-07-01

    Full Text Available Automatic Test Pattern Generation (ATPG is one of the core problems in testing of digital circuits. ATPG algorithms based on Boolean Satisfiability (SAT turned out to be very powerful, due to great advances in the performance of satisfiability solvers for propositional logic in the last two decades. SAT-based ATPG clearly outperforms classical approaches especially for hard-to-detect faults. But its inaccessibility of structural information and don’t care, there exists the over-specification problem of input patterns. In this paper we present techniques to delve into an additional layer to make use of structural properties of the circuit and value justification relations to a generic SAT algorithm. It joins binary decision graphs (BDD and SAT techniques to improve the efficiency of ATPG. It makes a study of inexpensive reconvergent fanout analysis of circuit to gather information on the local signal correlation by using BDD learning, then uses the above learned information to restrict and focus the overall search space of SAT-based ATPG. The learning technique is effective and lightweight. Experimental results show the effectiveness of the approach.

  14. Testing Different Survey Techniques to Model Architectonic Narrow Spaces

    Science.gov (United States)

    Mandelli, A.; Fassi, F.; Perfetti, L.; Polari, C.

    2017-08-01

    In the architectural survey field, there has been the spread of a vast number of automated techniques. However, it is important to underline the gap that exists between the technical specification sheet of a particular instrument and its usability, accuracy and level of automation reachable in real cases scenario, especially speaking about Cultural Heritage (CH) field. In fact, even if the technical specifications (range, accuracy and field of view) are known for each instrument, their functioning and features are influenced by the environment, shape and materials of the object. The results depend more on how techniques are employed than the nominal specifications of the instruments. The aim of this article is to evaluate the real usability, for the 1:50 architectonic restitution scale, of common and not so common survey techniques applied to the complex scenario of dark, intricate and narrow spaces such as service areas, corridors and stairs of Milan's cathedral indoors. Tests have shown that the quality of the results is strongly affected by side-issues like the impossibility of following the theoretical ideal methodology when survey such spaces. The tested instruments are: the laser scanner Leica C10, the GeoSLAM ZEB1, the DOT DPI 8 and two photogrammetric setups, a full frame camera with a fisheye lens and the NCTech iSTAR, a panoramic camera. Each instrument presents advantages and limits concerning both the sensors themselves and the acquisition phase.

  15. DSCu/SS joining techniques development and testing

    Energy Technology Data Exchange (ETDEWEB)

    Sato, Satoshi; Hatano, Toshihisa; Furuya, Kazuyuki; Kuroda, Toshimasa; Enoeda, Mikio; Takatsu, Hideyuki [Japan Atomic Energy Research Inst., Naka, Ibaraki (Japan). Naka Fusion Research Establishment

    1998-01-01

    Joining techniques of alumina dispersion strengthened copper alloy (DSCu) and type 316L stainless steel (SS) has been investigated aiming at applying to the fabrication of the ITER first wall/blanket. As the joining method, Hot Isostatic Pressing (HIP) of solid plates and/or blocks has been pursued. By a screening test including HIP temperatures of 980-1050degC, it was concluded that the HIP temperature of 1050degC would be optimum for the simultaneous HIPping of DSCu/DSCu, DSCu/SS and SS/SS. With DSCu/SS joint specimens HIPped at 1050degC, tensile, impact, fatigue, crack propagation, and fracture toughness tests were performed as well as mechanical test of structural model with one SS circular tube embedded. Typically, the properties of the joints were almost the same as those of DSCu or SS base metal with the same heat treatment of the HIP process, thus good joints were obtained, though parts of properties were decreased at elevated test temperature. Typical results of the mechanical test of structural mode indicated that a crack initiated at the inner surface of the SS tube under cyclic operation, and the lifetime of the first wall structure could be evaluated by existing SS fatigue data. Two HIPped first wall panel mock-ups were successfully fabricated with built-in coolant tubes: one was 300 mm long and the other 800 mm long. The former was thermo-mechanically tested with high heat fluxes corresponding to the ITER operation conditions. The mock-up showed good heat removal performance during the high heat flux tests. In addition, there were no cracks and delaminations found at HIPped interfaces by microscopic observation after all tests. Ultrasonic testing have been tried as a non-destructive examination method, and detectable defect size at SS/SS, DSCu/DSCu and DSCu/SS joint interfaces were estimated. (author)

  16. Comparing Cost-Effectiveness of HIV Testing Strategies: Targeted and Routine Testing in Washington, DC.

    Directory of Open Access Journals (Sweden)

    Amanda D Castel

    Full Text Available Routine HIV testing is an essential approach to identifying undiagnosed infections, linking people to care and treatment, and preventing new infections. In Washington, DC, where HIV prevalence is 2.4%, a combination of routine and targeted testing approaches has been implemented since 2006.We sought to evaluate the cost effectiveness of the District of Columbia (DC Department of Health's routine and targeted HIV testing implementation strategies. We collected HIV testing data from 3 types of DC Department of Health-funded testing sites (clinics, hospitals, and community-based organizations; collected testing and labor costs; and calculated effectiveness measures including cost per new diagnosis and cost per averted transmission.Compared to routine testing, targeted testing resulted in higher positivity rates (1.33% vs. 0.44%. Routine testing averted 34.30 transmissions per year compared to targeted testing at 17.78. The cost per new diagnosis was lower for targeted testing ($2,467 vs. $7,753 per new diagnosis as was the cost per transmission averted ($33,160 vs. $104,205. When stratified by testing site, both testing approaches were most cost effective in averting new transmissions when conducted by community based organizations ($25,037 routine; $33,123 targeted compared to hospitals or clinics.While routine testing identified more newly diagnosed infections and averted more infections than targeted testing, targeted testing is more cost effective per diagnosis and per transmission averted overall. Given the high HIV prevalence in DC, the DC Department of Health's implementation strategy should continue to encourage routine testing implementation with emphasis on a combined testing strategy among community-based organizations.

  17. A test of two depth profiling techniques using PIXE

    Science.gov (United States)

    Frontier, Jean-Pierre; Regnier, Pierre; Brilliard, Lucette; Brissaud, Ivan

    1986-03-01

    A destructive and a nondestructive technique for depth profiling using PIXE is tested on various concentration profiles of Zn depletion in initially homogeneous Ag 3 at.% Zn alloys. The first consists of measuring the yield of X-rays emerging from thin film targets prepared by deposition of Ag and Zn hydroxides originating from slabs of controlled thickness removed from the analysed sample. The second consists of deconvoluting a set of X-ray yield measurements carried out with various energies. Both techniques are cross-referenced with electron microprobe analysis run on a transverse section of the corresponding specimens, but can also be applied to profiles extending over depths too small for analysis on a transverse section. Internal coherence between the different concentration profiles obtained is checked on the basis of Zn diffusivity in Ag-Zn alloys.

  18. An equipment test for grading lumber by transverse vibration technique

    Directory of Open Access Journals (Sweden)

    Marcelo Rodrigo Carreira

    2008-08-01

    Full Text Available Due to the great variability of its mechanical properties, the rational use of lumber for structural purposes is directly conditioned to its grading. There are several techniques available for grading structural lumber. The most relevant one is the transverse vibration technique which obtained reliable results in non-destructive evaluation of lumber. The purpose of this work is to present the bases for the mechanical grading of lumber and the results of the calibration test of the frst transverse vibration equipment developed in Brazil. In this research 30 beams of cupiúba (Goupia glabra with nominal dimensions of 5 cm X 10 cm X 300 cm, were used. The tests were accomplished at the Wood and Timber Structures Laboratory (LaMEM of the University of São Paulo (USP. The results showed a strong correlation between the elasticity modulus measured by the static bending test and the one obtained with the transverse vibration equipment, showing the high reliability of the vibration method for the grading of structural lumber. A determination coeffcient (R² of 0.896 was obtained with the Brazilian equipment, showing that it can be used in the grading of lumber.

  19. Integrated testing strategy (ITS) for bioaccumulation assessment under REACH

    DEFF Research Database (Denmark)

    Lombardo, Anna; Roncaglioni, Alessandra; Benfentati, Emilio

    2014-01-01

    in a dossier. REACH promotes the use of alternative methods to replace, refine and reduce the use of animal (eco)toxicity testing. Within the EU OSIRIS project, integrated testing strategies (ITSs) have been developed for the rational use of non-animal testing approaches in chemical hazard assessment. Here we...... methods are used only as last resort. Using the ITS, in vivo testing could be waived for about 67% of the examined compounds, but bioaccumulation potential could be estimated on the basis of non-animal methods. The presented ITS is freely available through a web tool. © 2014 Elsevier Ltd....... present an ITS for evaluating the bioaccumulation potential of organic chemicals. The scheme includes the use of all available data (also the non-optimal ones), waiving schemes, analysis of physicochemical properties related to the end point and alternative methods (both in silico and in vitro). In vivo...

  20. Testing and assessment strategies, including alternative and new approaches

    DEFF Research Database (Denmark)

    Meyer, Otto A.

    2003-01-01

    The object of toxicological testing is to predict possible adverse effect in humans when exposed to chemicals whether used as industrial chemicals, pharmaceuticals or pesticides. Animal models are predominantly used in identifying potential hazards of chemicals. The use of laboratory animals raises...... ethical concern. However, irrespective of animal welfare it is an important aspect of the discipline of toxicology that the primary object is human health. The ideal testing and assessment strategy is simple to use all the available test methods and preferably more in laboratory animal species from which...... we get as many data as possible in order to obtain the most extensive database for the toxicological evaluation of a chemical. Consequently, the society has decided that certain group of chemicals should be tested accordingly. However, realising that, this idea is not obtainable in practice because...

  1. Cyber Security Test Strategy for Non-safety Display System

    Energy Technology Data Exchange (ETDEWEB)

    Son, Han Seong [Joongbu University, Geumsan (Korea, Republic of); Kim, Hee Eun [KAIST, Daejeon (Korea, Republic of)

    2016-10-15

    Cyber security has been a big issue since the instrumentation and control (I and C) system of nuclear power plant (NPP) is digitalized. A cyber-attack on NPP should be dealt with seriously because it might cause not only economic loss but also the radioactive material release. Researches on the consequences of cyber-attack onto NPP from a safety point of view have been conducted. A previous study shows the risk effect brought by initiation of event and deterioration of mitigation function by cyber terror. Although this study made conservative assumptions and simplifications, it gives an insight on the effect of cyber-attack. Another study shows that the error on a non-safety display system could cause wrong actions of operators. According to this previous study, the failure of the operator action caused by a cyber-attack on a display system might threaten the safety of the NPP by limiting appropriate mitigation actions. This study suggests a test strategy focusing on the cyber-attack on the information and display system, which might cause the failure of operator. The test strategy can be suggested to evaluate and complement security measures. Identifying whether a cyber-attack on the information and display system can affect the mitigation actions of operator, the strategy to obtain test scenarios is suggested. The failure of mitigation scenario is identified first. Then, for the test target in the scenario, software failure modes are applied to identify realistic failure scenarios. Testing should be performed for those scenarios to confirm the integrity of data and to assure effectiveness of security measures.

  2. The reliability of specific sacro-occipital technique diagnostic tests.

    Science.gov (United States)

    Leboeuf, C

    1991-01-01

    Four interexaminer and one intraexaminer agreement studies were performed on specific diagnostic tests commonly employed within sacro-occipital technique (SOT). Ten of the tests were evaluated in more than one interexaminer study. Of these, only one test (bilateral supine leg raise with cervical compaction) had at least fair reliability more than once. Six of these 10 tests obtained poor agreement in more than one study. One examiner out of two had a number of excellent and fair intraexaminer values, whereas the other examiner generally had poor results. There may have been some treatment effect as a comparison of the combined intraexaminer diagnosis for two observers after no treatment and after treatment showed that the repeatability diminished from Kappa of 0.36 in untreated cases (which were expected to have high agreement of before and after treatment findings) to a Kappa of 0.27 for those subjects having received treatment (which were expected to have low agreement of before and after treatment findings). It appears unlikely that SOT tests can be reproduced to a sufficiently high degree to constitute useful clinical procedures.

  3. Testing aspects of advanced coherent electron cooling technique

    Energy Technology Data Exchange (ETDEWEB)

    Litvinenko, V.; Jing, Y.; Pinayev, I.; Wang, G.; Samulyak, R.; Ratner, D.

    2015-05-03

    An advanced version of the Coherent-electron Cooling (CeC) based on the micro-bunching instability was proposed. This approach promises significant increase in the bandwidth of the CeC system and, therefore, significant shortening of cooling time in high-energy hadron colliders. In this paper we present our plans of simulating and testing the key aspects of this proposed technique using the set-up of the coherent-electron-cooling proof-of-principle experiment at BNL.

  4. Clinical trial of a new technique for drugs of abuse testing: a new possible sampling technique.

    Science.gov (United States)

    Skoglund, Charlotte; Hermansson, Ulric; Beck, Olof

    2015-01-01

    Exhaled breath has recently been proposed as a matrix for drug testing. This study aims to further explore, develop and validate exhaled breath as a safe and effective non-invasive method for drug testing in a clinical setting. Self-reported drug use was recorded and drug testing was performed by mass spectrometry and immunochemical methods using breath, plasma and urine samples from 45 individuals voluntarily seeking treatment for recreational drug use. Cannabis was the most prevalent drug detected by any method. Urine sampling detected most cases. The exhaled breath technique was less sensitive (73%) than plasma analysis for detection of cannabis uses but captures a more recent drug intake than both plasma and urine. Exhaled breath was the preferred specimen to donate according to interview data of the participants. Testing illicit drugs with the exhaled breath sampling technique is a sufficient, non-invasive and safe alternative and complement to plasma and/or urine sampling. Copyright © 2014 Elsevier Inc. All rights reserved.

  5. Association testing strategy for data from dense marker panels.

    Directory of Open Access Journals (Sweden)

    Donghyung Lee

    Full Text Available Genome wide association studies have been usually analyzed in a univariate manner. The commonly used univariate tests have one degree of freedom and assume an additive mode of inheritance. The experiment-wise significance of these univariate statistics is obtained by adjusting for multiple testing. Next generation sequencing studies, which assay 10-20 million variants, are beginning to come online. For these studies, the strategy of additive univariate testing and multiple testing adjustment is likely to result in a loss of power due to (1 the substantial multiple testing burden and (2 the possibility of a non-additive causal mode of inheritance. To reduce the power loss we propose: a new method (1 to summarize in a single statistic the strength of the association signals coming from all not-very-rare variants in a linkage disequilibrium block and (2 to incorporate, in any linkage disequilibrium block statistic, the strength of the association signals under multiple modes of inheritance. The proposed linkage disequilibrium block test consists of the sum of squares of nominally significant univariate statistics. We compare the performance of this method to the performance of existing linkage disequilibrium block/gene-based methods. Simulations show that (1 extending methods to combine testing for multiple modes of inheritance leads to substantial power gains, especially for a recessive mode of inheritance, and (2 the proposed method has a good overall performance. Based on simulation results, we provide practical advice on choosing suitable methods for applied analyses.

  6. Comparative testing of nondestructive examination techniques for concrete structures

    Science.gov (United States)

    Clayton, Dwight A.; Smith, Cyrus M.

    2014-03-01

    A multitude of concrete-based structures are typically part of a light water reactor (LWR) plant to provide foundation, support, shielding, and containment functions. Concrete has been used in the construction of nuclear power plants (NPPs) because of three primary properties, its inexpensiveness, its structural strength, and its ability to shield radiation. Examples of concrete structures important to the safety of LWR plants include containment building, spent fuel pool, and cooling towers. Comparative testing of the various NDE concrete measurement techniques requires concrete samples with known material properties, voids, internal microstructure flaws, and reinforcement locations. These samples can be artificially created under laboratory conditions where the various properties can be controlled. Other than NPPs, there are not many applications where critical concrete structures are as thick and reinforced. Therefore, there are not many industries other than the nuclear power plant or power plant industry that are interested in performing NDE on thick and reinforced concrete structures. This leads to the lack of readily available samples of thick and heavily reinforced concrete for performing NDE evaluations, research, and training. The industry that typically performs the most NDE on concrete structures is the bridge and roadway industry. While bridge and roadway structures are thinner and less reinforced, they have a good base of NDE research to support their field NDE programs to detect, identify, and repair concrete failures. This paper will summarize the initial comparative testing of two concrete samples with an emphasis on how these techniques could perform on NPP concrete structures.

  7. Ground vibration tests of a helicopter structure using OMA techniques

    Science.gov (United States)

    Ameri, N.; Grappasonni, C.; Coppotelli, G.; Ewins, D. J.

    2013-02-01

    This paper is focused on an assessment of the state-of-the-art of operational modal analysis (OMA) methodologies in estimating modal parameters from output responses on helicopter structures. For this purpose, a ground vibration test was performed on a real helicopter airframe. In the following stages, several OMA techniques were applied to the measured data and compared with the results from typical input-output approach. The results presented are part of a more general research activity carried out in the Group of Aeronautical Research and Technology in Europe (GARTEUR) Action Group 19, helicopter technical activity, whose overall objective is the improvement of the structural dynamic finite element models using in-flight test data. The structure considered is a medium-size helicopter, a time-expired Lynx Mk7 (XZ649) airframe. In order to have a comprehensive analysis, the behaviour of both frequency- and time-domain-based OMA techniques are considered for the modal parameter estimates. An accuracy index and the reliability of the OMA methods with respect to the standard EMA procedures, together with the evaluation of the influence of the experimental setup on the estimate of the modal parameters, will be presented in the paper.

  8. Research on technique of wavefront retrieval based on Foucault test

    Science.gov (United States)

    Yuan, Lvjun; Wu, Zhonghua

    2010-05-01

    During finely grinding the best fit sphere and initial stage of polishing, surface error of large aperture aspheric mirrors is too big to test using common interferometer. Foucault test is widely used in fabricating large aperture mirrors. However, the optical path is disturbed seriously by air turbulence, and changes of light and dark zones can not be identified, which often lowers people's judging ability and results in making mistake to diagnose surface error of the whole mirror. To solve the problem, the research presents wavefront retrieval based on Foucault test through digital image processing and quantitative calculation. Firstly, real Foucault image can be gained through collecting a variety of images by CCD, and then average these image to eliminate air turbulence. Secondly, gray values are converted into surface error values through principle derivation, mathematical modeling, and software programming. Thirdly, linear deviation brought by defocus should be removed by least-square method to get real surface error. At last, according to real surface error, plot wavefront map, gray contour map and corresponding pseudo color contour map. The experimental results indicates that the three-dimensional wavefront map and two-dimensional contour map are able to accurately and intuitively show surface error on the whole mirrors under test, and they are beneficial to grasp surface error as a whole. The technique can be used to guide the fabrication of large aperture and long focal mirrors during grinding and initial stage of polishing the aspheric surface, which improves fabricating efficiency and precision greatly.

  9. Nuclear thermal propulsion test facility requirements and development strategy

    Science.gov (United States)

    Allen, George C.; Warren, John; Clark, J. S.

    1991-01-01

    The Nuclear Thermal Propulsion (NTP) subpanel of the Space Nuclear Propulsion Test Facilities Panel evaluated facility requirements and strategies for nuclear thermal propulsion systems development. High pressure, solid core concepts were considered as the baseline for the evaluation, with low pressure concepts an alternative. The work of the NTP subpanel revealed that a wealth of facilities already exists to support NTP development, and that only a few new facilities must be constructed. Some modifications to existing facilities will be required. Present funding emphasis should be on long-lead-time items for the major new ground test facility complex and on facilities supporting nuclear fuel development, hot hydrogen flow test facilities, and low power critical facilities.

  10. Nuclear thermal propulsion test facility requirements and development strategy

    Science.gov (United States)

    Allen, George C.; Clark, John S.; Warren, John; Perkins, David R.; Martinell, John

    1992-01-01

    The Nuclear Thermal Propulsion (NTP) subpanel of the Space Nuclear Propulsion Test Facilities Panel evaluated facility requirements and strategies for nuclear thermal propulsion systems development. High pressure, solid core concepts were considered as the baseline for the evaluation, with low pressure concepts an alternative. The work of the NTP subpanel revealed that a wealth of facilities already exists to support NTP development, and that only a few new facilities must be constructed. Some modifications to existing facilities will be required. Present funding emphasis should be on long-lead-time items for the major new ground test facility complex and on facilities supporting nuclear fuel development, hot hydrogen flow test facilities, and low power critical facilities.

  11. Recall strategies for the verbal fluency test in patients with multiple sclerosis.

    Science.gov (United States)

    Velázquez-Cardoso, J; Marosi-Holczberger, E; Rodríguez-Agudelo, Y; Yañez-Tellez, G; Chávez-Oliveros, M

    2014-04-01

    Multiple sclerosis (MS) is a neurodegenerative disease characterised by inflammation and demyelination. It generates irreversible myelin changes, which in turn give rise to physical and cognitive disorders. The verbal fluency test (VF) has been shown to be a sensitive tool for detecting cognitive impairment in these patients. To compare quantitative and qualitative aspects of performance on semantic and phonological fluency tests between MS patients and healthy controls by analysing total words produced and strategies used (clusters and switching). We evaluated 46 patients with MS and 33 healthy controls using the VF test. The semantic VF task revealed no significant differences between groups; for the phonological task, patients demonstrated reduced word production (F [77]=2.286 P<.001) and poorer use of grouping strategies, resulting in more frequent switching (F [77]=3.808 P<.005). These results support using qualitative analysis for recall strategies, since the technique provides data about which components of the task are affected by brain damage. Clusters depend on the integrity of semantic memory, while switching has to do with developing effective search strategies, cognitive flexibility, and the ability to modify responses. Frontal lobe damage has been reported in MS, and this is consistent with results from the phonological VF test. Copyright © 2012 Sociedad Española de Neurología. Published by Elsevier Espana. All rights reserved.

  12. Imaging techniques for ultrasonic testing; Bildgebende Verfahren fuer die Ultraschallpruefung

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-07-01

    These seminar proceedings contain 16 lectures on the following topics: 1. From imaging to quantification - ultrasound methods in medical diagnostics; 2. SAFT, TOFD, Phased Array - classical applications and recent developments in ultrasonic imaging; 3. Innovative ultrasonic imaging methods in research and application; 4. Industrial ultrasonic testing of fibre-reinforced structures of complex geometry; 5. Visualisation of crack tips in the inspection of wheel set shafts with longitudinal boreholes as a means of avoiding unnecessary wheel set changes; 6. Areal analysis of the propagation of Lamb waves on curved, anisotropic structures; 7. High-resolution representation in immersion technique testing; 8. Variants in generating images from phased array measurement data - practical examples involving copper, carbon-fibre reinforced plastic and other materials; 9. GIUM - an unconventional method of microstructure imaging using ultrasonic stimulation and laser vibrometry scanning; 10. Innovative air-ultrasonic testing concepts for improved imaging; 11. Use of imaging methods for improving the quality of test results from nondestructive testing; 12. Modelling and visualisation of EMUS stimulation for transducer optimisation; 13. Use of SAFT in the manufacture of energy conversion machines; 14. Ultrasonic imaging tests for improved defect characterisation during weld seam inspection on longitudinally welded large-diameter pipes; 15. SAFT reconstruction for testing austenitic weld seams and dissimilar metal weld seams for transverse cracks; 16. Imaging-based optimisation method for quantitative ultrasonic testing of anisotropic inhomogeneous austenitic welded joints with determination and utilisation of their elastic properties. One contribution has been abstracted separately. [German] Dieser Seminarband enthaelt 16 Vortraege mit folgenden Themen: 1. Von der Bildgebung bis zur Quantifizierung - Ultraschallverfahren in der medizinischen Diagnostik; 2. SAFT, TOFD, Phased Array

  13. Cyclic Testing of 3 Medial Patellofemoral Ligament Reconstruction Techniques

    Science.gov (United States)

    Mehta, Vishal; Mandala, Cassie; Akhter, Ahmed

    2017-01-01

    Background: Several techniques are available to secure the graft to the patella during medial patellofemoral ligament (MPFL) reconstruction. The biomechanical properties of these techniques remain unknown. Purpose: To compare the biomechanical properties of 3 MPFL patellar fixation techniques: bone tunnels (BT), PushLock anchors (PL), and tenodesis screws (TS). Study Design: Controlled laboratory study. Methods: Forty-five MPFL reconstructions were performed using 3 different reconstruction techniques (BT, PL, and TS). The specimens were randomly assigned, with 15 specimens in each of the 3 groups. Cyclic loading (500 cycles) and load-to-failure testing were performed. Gap formation after 100 and 500 cycles, ultimate load to failure, and stiffness were measured. Results: Six constructs failed during cyclic loading, 5 in the PL group (33%) and 1 in the TS group (6.7%). After 100 cycles, differences in gap formation were found between the PL and BT groups (4.48 vs 3.62 mm, P < .03) and between the PL and TS groups (4.48 vs 2.28 mm, P < .0001). After 500 cycles, differences in gap formation were found between the BT and TS groups (6.63 vs 4.16 mm, P < .002) and between the PL and TS groups (7.89 vs 4.16 mm, P < .005). The PL group was found to have a lower ultimate load to failure when compared with the BT group (161.4 vs 258.3 N, P = .019) and the TS group (161.4 vs 237.1 N, P = .009). Group differences in stiffness did not reach statistical significance among the 3 groups (PL, 33.72 N/mm; BT, 37.50 N/mm; TS, 43.00 N/mm). Conclusion: The TS and BT groups have more ideal biomechanical properties than the PL group, as demonstrated by less displacement during cyclic loading and a higher load to failure. Clinical Relevance: Fixation of the patellar limbs during MPFL reconstruction may be optimized with the use of TS or BT over a PL technique. PMID:28680899

  14. Analysis of Test Takers' Metacognitive and Cognitive Strategy Use and EFL Reading Test Performance: A Multi-Sample SEM Approach

    Science.gov (United States)

    Zhang, Limei; Goh, Christine C. M.; Kunnan, Antony John

    2014-01-01

    This study investigates the relationships between test takers' metacognitive and cognitive strategy use through a questionnaire and their test performance on an English as a Foreign Language reading test. A total of 593 Chinese college test takers responded to a 38-item metacognitive and cognitive strategy questionnaire and a 50-item reading test.…

  15. Maximizing efficacy of endocrine tests: importance of decision-focused testing strategies and appropriate patient preparation.

    Science.gov (United States)

    Klee, G G

    1999-08-01

    The efficacy of endocrine tests depends on the choice of tests, the preparation of the patients, the integrity of the specimens, the quality of the measurements, and the validity of the reference data. Close dialogue among the clinicians, the laboratory, and the patients is a key factor for optimal patient care. The characteristics of urine and plasma samples and the advantages and limitations of paired test measurements are presented. The importance of test sequence strategies, provocative or inhibitory procedures, and elimination of drug interferences is illustrated with four cases involving Cushing syndrome, pheochromocytoma, primary aldosteronism, and hypercalcemia. For each of these scenarios, key clinical issues are highlighted, along with discussions of the best test strategies, including which medications are likely to interfere. The importance of targeting laboratory tests to answer well-focused clinical decisions is emphasized. The roles of some time-honored provocative procedures are questioned in light of more sensitive and specific analytic methods. The importance of decision-focused analytical tolerance limits is emphasized by demonstrating the impact of analytic bias on downstream medical resource utilization. User-friendly support systems to facilitate the implementation of test strategies and postanalytic tracking of patient outcomes are presented as essential requirements for quality medical practice.

  16. The effects of two different correction strategies on the snatch technique in weightlifting.

    Science.gov (United States)

    Milanese, Chiara; Cavedon, Valentina; Corte, Stefano; Agostini, Tiziano

    2017-03-01

    Improving motor skills represents one of the major issues in motor control and motor learning literature. The aim of this study was to investigate which of two strategies, method of amplification of error (MAE) or direct instruction (DI), would be more beneficial for error correction of the snatch technique. Thirty well-trained male weightlifters were randomly assigned to one of three training conditions (MAE, DI and Control). The experiment took place in only one practice session in which each lifter performed 3 pretraining trials, 8 training intervention trials, and 3 post-training trials, and a retention test session after 1 week. An optoelectronic motion capture system was used to measure the kinematic parameters of the weightlifting performance. After the training intervention, data showed that the MAE group revealed a greater improvement in several kinematic parameters when compared to the DI and Control groups, and the benefits derived from its application were still present 1 week later in the retention test. Nevertheless, the findings of the present study should be interpreted with caution due to the relatively small sample size; further research will also be necessary to evaluate the effects of MAE with different ability levels and other sport skills. The present findings could have practical implications for sport psychology and physical education because while practice is obviously necessary for improving learning, the efficacy of the learning process is essential in enhancing learners' motivation and sport enjoyment.

  17. Integrating non-animal test information into an adaptive testing strategy - skin sensitization proof of concept case.

    Science.gov (United States)

    Jaworska, Joanna; Harol, Artsiom; Kern, Petra S; Gerberick, G Frank

    2011-01-01

    There is an urgent need to develop data integration and testing strategy frameworks allowing interpretation of results from animal alternative test batteries. To this end, we developed a Bayesian Network Integrated Testing Strategy (BN ITS) with the goal to estimate skin sensitization hazard as a test case of previously developed concepts (Jaworska et al., 2010). The BN ITS combines in silico, in chemico, and in vitro data related to skin penetration, peptide reactivity, and dendritic cell activation, and guides testing strategy by Value of Information (VoI). The approach offers novel insights into testing strategies: there is no one best testing strategy, but the optimal sequence of tests depends on information at hand, and is chemical-specific. Thus, a single generic set of tests as a replacement strategy is unlikely to be most effective. BN ITS offers the possibility of evaluating the impact of generating additional data on the target information uncertainty reduction before testing is commenced.

  18. Testing a luminescence surface-exposure dating technique

    Science.gov (United States)

    Gliganic, Luke A.; Meyer, Michael; Gehring, Sebastian

    2016-04-01

    Recent work has shown that the relationship between the luminescence signal (optically stimulated [OSL] and infra-red stimulated [IRSL]) and depth into a rock surface can be used to estimate the length of time since that rock surface has been exposed to sunlight (Sohbati et al., 2012), thus serving as a means for surface-exposure dating. Despite the potential of this new dating tool, few published studies have tested or used this technique. Here, we present the results of two tests of the method. First, we perform laboratory bleaching experiments using two unexposed bedrock samples of different lithologies (granite and quartzite). Sub-samples were bleached for various durations (0 to 100,000 s) in a solar simulator, and IRSL/OSL-depth profiles were measured and fitted using the model of Sohbati et al. (2012). Results of fitting for each sub-sample were then compared. Second, we used a granite boulder from a known age moraine (1850 CE) to test the reproducibility of bleaching depth curves. Multiple cores were collected from the same ~5 cm2 surface area of the boulder, and IRSL-depth profiles were measured and modelled. While our systematic tests confirm the general physical basis of luminescence surface-exposure dating method, we found unexpected scatter in both adjacent bleaching depth curves and the fitting parameters of isochronous rock surfaces for some of our samples. Potential sources of error, including small-scale lithological variabilities and implications for accuracy and precision of the method are discussed. Sohbati, R., Murray, A.S., Chapot, M.S., Jain, M., Pederson, J. (2012) Optically stimulated luminescence (OSL) as a chronometer for surface exposure dating. Journal of Geophysical Research 117 (B9), B09202. doi.org/10.1029/2012JB009383.

  19. Cognitive decision strategies adopted by consumers in reminder difference tests: Influence of the authenticity test.

    Science.gov (United States)

    Stocks, M; Shepherd, D; Lee, H-S; van Hout, D; Hautus, M J

    2017-07-01

    Discrimination tests are used in food companies to quantify small differences between products. Within the diversity of methods available, some are quicker to conduct, whereas others are more sensitive or statistically powerful. One class of methods includes the reminder tasks in which the reference product is given before tasting the actual test stimuli. During the task, such a 'reminder' can be compared directly to each test stimulus, or alternatively, only serve to prime the memory of the judge without being taken into account in decision-making. Previous research with trained judges provided evidence for the latter process while research with untrained consumers has provided some evidence for the former process. Two studies were conducted with untrained consumers using the A Not-AR and 2-AFCR reminder tasks. Objectives were to determine the decision strategies used in, and the relative sensitivity of the tasks. In addition, the use of an "authenticity test" was explored to see if this has a positive effect on test performance. In the first study, mayonnaise and ice tea with small stimulus differences (d'decision strategy used, though the use of an authenticity test increased the sensitivity for these small differences, as it improved the performance of 6 out of 8 tests. In the second study, ice teas with larger stimulus differences (at two levels) were tested using the A Not-AR and 2-AFCR tasks, in comparison to the same-different task. The results showed that consumers use the less optimal strategies and that the authenticity test decreases performance, which is contradictory to the results of the first study. It seems that for very small stimulus differences the authenticity test can improve performance, but with larger differences the authenticity test decreases performance; it seems to confuse the judges. Copyright © 2017 Elsevier Ltd. All rights reserved.

  20. Study on ABCD Analysis Technique for Business Models, business strategies, Operating Concepts & Business Systems

    OpenAIRE

    Aithal, Sreeramana

    2016-01-01

    Studying the implications of a business model, choosing success strategies, developing viable operational concepts or evolving a functional system, it is important to analyse it in all dimensions. For this purpose, various analysing techniques/frameworks are used. This paper is a discussion on how to use an innovative analysing framework called ABCD model on a given business model, or on a business strategy or a operational concept/idea or business system. Based on four constructs Advantages,...

  1. Identifying main drivers and testing control strategies for CCHFV spread.

    Science.gov (United States)

    Hoch, T; Breton, E; Josse, M; Deniz, A; Guven, E; Vatansever, Z

    2016-03-01

    Crimean Congo Haemorrhagic Fever (CCHF) is an emerging zoonotic disease. The causative agent is a virus (CCHFV), mainly transmitted by ticks of the species Hyalomma marginatum in Eastern Europe and Turkey. In order to test potential scenarios for the control of pathogen spread, the basic reproduction number (R0) for CCHF was calculated. This calculation was based on a population dynamics model and parameter values from the literature for pathogen transmission. The tick population dynamics model takes into account the major processes involved and gives estimates for tick survival from one stage to the other and number of feeding ticks. It also considers the influence of abiotic (meteorological variables) and biotic factors (host densities) on model outputs, which were compared with data collected in Central Anatolia (Turkey). R0 computation was thereafter used to test control strategies and especially the effect of acaricide treatment. Simulation results indicate that such treatments could have valuable effects provided that the acaricide is applied regularly throughout the spring and summer, and over several years. Furthermore, a sensitivity analysis to abiotic and biotic factors showed that, even though temperature has a strong impact on model outputs, host (mainly hare) densities also play a role. The kind of model we have developed provides insight into the ability of different strategies to prevent and control disease spread and has proved its relevance when associated with field trials.

  2. The Effect of Test Expectations on Study Strategies and Test Performance: A Metacognitive Perspective

    Science.gov (United States)

    Abd-El-Fattah, Sabry M.

    2011-01-01

    The aim of the present study was to investigate whether university students can adjust their study strategies to meet the cognitive demands of testing; a metacognitive self-regulatory skill. One hundred and fifty undergraduates attended three lectures as part of a course on the psychology of individual differences. These participants were then…

  3. Study of Semi-Span Model Testing Techniques

    Science.gov (United States)

    Gatlin, Gregory M.; McGhee, Robert J.

    1996-01-01

    An investigation has been conducted in the NASA Langley 14- by 22-Foot Subsonic Tunnel in order to further the development of semi-span testing capabilities. A twin engine, energy efficient transport (EET) model with a four-element wing in a takeoff configuration was used for this investigation. Initially a full span configuration was tested and force and moment data, wing and fuselage surface pressure data, and fuselage boundary layer measurements were obtained as a baseline data set. The semi-span configurations were then mounted on the wind tunnel floor, and the effects of fuselage standoff height and shape as well as the effects of the tunnel floor boundary layer height were investigated. The effectiveness of tangential blowing at the standoff/floor juncture as an active boundary-layer control technique was also studied. Results indicate that the semi-span configuration was more sensitive to variations in standoff height than to variations in floor boundary layer height. A standoff height equivalent to 30 percent of the fuselage radius resulted in better correlation with full span data than no standoff or the larger standoff configurations investigated. Undercut standoff leading edges or the use of tangential blowing in the standoff/ floor juncture improved correlation of semi-span data with full span data in the region of maximum lift coefficient.

  4. Integrated testing strategy (ITS) for bioaccumulation assessment under REACH.

    Science.gov (United States)

    Lombardo, Anna; Roncaglioni, Alessandra; Benfentati, Emilio; Nendza, Monika; Segner, Helmut; Fernández, Alberto; Kühne, Ralph; Franco, Antonio; Pauné, Eduard; Schüürmann, Gerrit

    2014-08-01

    REACH (registration, evaluation, authorisation and restriction of chemicals) regulation requires that all the chemicals produced or imported in Europe above 1 tonne/year are registered. To register a chemical, physicochemical, toxicological and ecotoxicological information needs to be reported in a dossier. REACH promotes the use of alternative methods to replace, refine and reduce the use of animal (eco)toxicity testing. Within the EU OSIRIS project, integrated testing strategies (ITSs) have been developed for the rational use of non-animal testing approaches in chemical hazard assessment. Here we present an ITS for evaluating the bioaccumulation potential of organic chemicals. The scheme includes the use of all available data (also the non-optimal ones), waiving schemes, analysis of physicochemical properties related to the end point and alternative methods (both in silico and in vitro). In vivo methods are used only as last resort. Using the ITS, in vivo testing could be waived for about 67% of the examined compounds, but bioaccumulation potential could be estimated on the basis of non-animal methods. The presented ITS is freely available through a web tool. Copyright © 2014 Elsevier Ltd. All rights reserved.

  5. Estrogen receptor testing and 10-year mortality from breast cancer: A model for determining testing strategy

    Directory of Open Access Journals (Sweden)

    Christopher Naugler

    2012-01-01

    Full Text Available Background: The use of adjuvant tamoxifen therapy in the treatment of estrogen receptor (ER expressing breast carcinomas represents a major advance in personalized cancer treatment. Because there is no benefit (and indeed there is increased morbidity and mortality associated with the use of tamoxifen therapy in ER-negative breast cancer, its use is restricted to women with ER expressing cancers. However, correctly classifying cancers as ER positive or negative has been challenging given the high reported false negative test rates for ER expression in surgical specimens. In this paper I model practice recommendations using published information from clinical trials to address the question of whether there is a false negative test rate above which it is more efficacious to forgo ER testing and instead treat all patients with tamoxifen regardless of ER test results. Methods: I used data from randomized clinical trials to model two different hypothetical treatment strategies: (1 the current strategy of treating only ER positive women with tamoxifen and (2 an alternative strategy where all women are treated with tamoxifen regardless of ER test results. The variables used in the model are literature-derived survival rates of the different combinations of ER positivity and treatment with tamoxifen, varying true ER positivity rates and varying false negative ER testing rates. The outcome variable was hypothetical 10-year survival. Results: The model predicted that there will be a range of true ER rates and false negative test rates above which it would be more efficacious to treat all women with breast cancer with tamoxifen and forgo ER testing. This situation occurred with high true positive ER rates and false negative ER test rates in the range of 20-30%. Conclusions: It is hoped that this model will provide an example of the potential importance of diagnostic error on clinical outcomes and furthermore will give an example of how the effect of that

  6. Testing and validation of multi-lidar scanning strategies for wind energy applications: Testing and validation of multi-lidar scanning strategies for wind energy applications

    Energy Technology Data Exchange (ETDEWEB)

    Newman, Jennifer F. [School of Meteorology, University of Oklahoma, Norman Oklahoma USA; Current affiliation: National Wind Technology Center, National Renewable Energy Laboratory, Golden Colorado USA; Bonin, Timothy A. [School of Meteorology, University of Oklahoma, Norman Oklahoma USA; Current affiliation: Cooperative Institute for Research in the Environmental Sciences, University of Colorado, and National Oceanic and Atmospheric Administration/Earth System Research Laboratory, Boulder Colorado USA; Klein, Petra M. [School of Meteorology, University of Oklahoma, Norman Oklahoma USA; Wharton, Sonia [Atmospheric, Earth and Energy Division, Lawrence Livermore National Laboratory, Livermore California USA; Newsom, Rob K. [Pacific Northwest National Laboratory, Richland Washington USA

    2016-03-16

    Several factors cause lidars to measure different values of turbulence than an anemometer on a tower, including volume averaging, instrument noise, and the use of a scanning circle to estimate the wind field. One way to avoid the use of a scanning circle is to deploy multiple scanning lidars and point them toward the same volume in space to collect velocity measurements and extract high-resolution turbulence information. This paper explores the use of two multi-lidar scanning strategies, the tri-Doppler technique and the virtual tower technique, for measuring 3-D turbulence. In Summer 2013, a vertically profiling Leosphere WindCube lidar and three Halo Photonics Streamline lidars were operated at the Southern Great Plains Atmospheric Radiation Measurement site to test these multi-lidar scanning strategies. During the first half of the field campaign, all three scanning lidars were pointed at approximately the same point in space and a tri-Doppler analysis was completed to calculate the three-dimensional wind vector every second. Next, all three scanning lidars were used to build a “virtual tower” above the WindCube lidar. Results indicate that the tri-Doppler technique measures higher values of horizontal turbulence than the WindCube lidar under stable atmospheric conditions, reduces variance contamination under unstable conditions, and can measure highresolution profiles of mean wind speed and direction. The virtual tower technique provides adequate turbulence information under stable conditions but cannot capture the full temporal variability of turbulence experienced under unstable conditions because of the time needed to readjust the scans.

  7. Design of Sequentially Randomized Trials for Testing Adaptive Treatment Strategies

    Science.gov (United States)

    Ogbagaber, Semhar B.; Karp, Jordan; Wahed, Abdus S.

    2016-01-01

    An adaptive treatment strategy (ATS) is an outcome-guided algorithm that allows personalized treatment of complex diseases based on patients’ disease status and treatment history. Conditions such as AIDS, depression, and cancer usually require several stages of treatment due to the chronic, multifactorial nature of illness progression and management. Sequential multiple assignment randomized (SMAR) designs permit simultaneous inference about multiple ATSs, where patients are sequentially randomized to treatments at different stages depending upon response status. The purpose of the article is to develop a sample size formula to ensure adequate power for comparing two or more ATSs. Based on a Wald-type statistic for comparing multiple ATSs with a continuous endpoint, we develop a sample size formula and test it through simulation studies. We show via simulation that the proposed sample size formula maintains the nominal power. The proposed sample size formula is not applicable to designs with time-to-event endpoints but the formula will be useful for practitioners while designing SMAR trials to compare adaptive treatment strategies. PMID:26412033

  8. Application of Multivariable Statistical Techniques in Plant-wide WWTP Control Strategies Analysis

    DEFF Research Database (Denmark)

    Flores Alsina, Xavier; Comas, J.; Rodríguez-Roda, I.

    2007-01-01

    The main objective of this paper is to present the application of selected multivariable statistical techniques in plant-wide wastewater treatment plant (WWTP) control strategies analysis. In this study, cluster analysis (CA), principal component analysis/factor analysis (PCA/FA) and discriminant...

  9. Strategies to prevent forest fires and techniques to reverse degradation processes in burned areas

    NARCIS (Netherlands)

    Ferreira, António José Dinis; Alegre, Sérgio Prats; Coelho, Celeste Oliveira Alves; Shakesby, Rick A.; Páscoa, Fernando M.; Ferreira, Carla Sofia Santos; Keizer, Jan Jacob; Ritsema, Coen

    2015-01-01

    Forest fires are probably the more deleterious event in forest and range areas in the Mediterranean nowadays. Despite the significant area burned every year, little has been done to develop strategies and techniques for soil and water conservation in burned areas, despite the major impacts on soi

  10. Teaching Vocabulary: The Relationship between Techniques of Teaching and Strategies of Learning New Vocabulary Items

    Science.gov (United States)

    Elyas, Tariq; Alfaki, Ibrahim

    2014-01-01

    This study aims to investigate the techniques of teaching new lexis which are adopted by non-native teachers of English language. It also aims to investigate the strategies of learning new lexis which are adopted by learners in relation to their level. The work is based on two hypotheses: It is hypothesized that there is a relationship between the…

  11. Teaching during clinical practice: strategies and techniques used by preceptors in nursing education.

    Science.gov (United States)

    Elisabeth, Carlson; Christine, Wann-Hansson; Ewa, Pilhammar

    2009-07-01

    The preceptor is a nurse who teaches and supports the student and is seen as pivotal to student learning within the clinical setting. Earlier studies have shown that preceptors' pedagogical competence is significant for facilitating learning during clinical practice. However, studies describing pedagogical competence, especially in terms of teaching strategies, seem to be scarce. The aim of this study was to describe which strategies and techniques preceptors use to teach undergraduate nursing students during clinical practice. The study had an ethnographic approach; methods used were participant observations and focus group interviews with nurses who were experienced in precepting undergraduate nursing students. Findings illustrated how preceptors used different strategies and techniques in a continuous process of adjusting, performing and evaluating precepting. Increased knowledge on how the preceptors actually teach student nurses during clinical practice will help facilitate educational programmes for preceptors, which will enhance their pedagogical skills and competences.

  12. Investigation of energy management strategies for photovoltaic systems - An analysis technique

    Science.gov (United States)

    Cull, R. C.; Eltimsahy, A. H.

    1982-01-01

    Progress is reported in formulating energy management strategies for stand-alone PV systems, developing an analytical tool that can be used to investigate these strategies, applying this tool to determine the proper control algorithms and control variables (controller inputs and outputs) for a range of applications, and quantifying the relative performance and economics when compared to systems that do not apply energy management. The analysis technique developed may be broadly applied to a variety of systems to determine the most appropriate energy management strategies, control variables and algorithms. The only inputs required are statistical distributions for stochastic energy inputs and outputs of the system and the system's device characteristics (efficiency and ratings). Although the formulation was originally driven by stand-alone PV system needs, the techniques are also applicable to hybrid and grid connected systems.

  13. Investigation of energy management strategies for photovoltaic systems - An analysis technique

    Science.gov (United States)

    Cull, R. C.; Eltimsahy, A. H.

    1982-01-01

    Progress is reported in formulating energy management strategies for stand-alone PV systems, developing an analytical tool that can be used to investigate these strategies, applying this tool to determine the proper control algorithms and control variables (controller inputs and outputs) for a range of applications, and quantifying the relative performance and economics when compared to systems that do not apply energy management. The analysis technique developed may be broadly applied to a variety of systems to determine the most appropriate energy management strategies, control variables and algorithms. The only inputs required are statistical distributions for stochastic energy inputs and outputs of the system and the system's device characteristics (efficiency and ratings). Although the formulation was originally driven by stand-alone PV system needs, the techniques are also applicable to hybrid and grid connected systems.

  14. [A novel approach to techniques in genetic testing for cancer].

    Science.gov (United States)

    Kato, Jun-ichi

    2014-04-01

    In molecular targeted drug therapy, genetic screening is carried out to identify the existence of target genes that are specifically expressed in cancer cells. Conventional methods for detecting the mutation of genes in cancer cells through the use of purified DNA is time consuming, especially in the case of the enzymatic treatment of pathological specimens, and it is difficult to finish all these protocols on the same day. Also, depending on the condition of the patients, it may be difficult to perform surgery or biopsy, and pathological specimens are not always obtainable. Thus, sometimes genetic screening using purified DNA and the enzymatic treatment of pathological specimens cannot be performed. We have successfully solved these problems using i-densy, a genetic analysis device, and two different methods of genetic testing for cancer. The first is a method which, without extracting DNA, uses simply pretreated pathological specimens for genetic screening. Using deparaffinized specimens that have only been heat-treated for a short period of time, we were able to obtain the exact same results as if we had extracted DNA. The second is the highly specific genetic screening technique, the MBP-QP method. Using this method, we were able to confirm the detection of genetic mutation from the DNA of blood plasma. It is now possible to screen for the mutation of genes in cancer cells using just a blood sample from patients without using tissue or cells, which also has little burden on the patient.

  15. Optimal Bidding Strategies using New Aggregated Demand Model with Particle Swarm Optimization Technique

    Directory of Open Access Journals (Sweden)

    Dr.B.Subramanyam

    2013-02-01

    Full Text Available In this paper, Particle Swarm optimization(PSO and Artificial Bee Colony (ABC algorithms are used to determine the optimal bidding strategy in competitive auction market implementation. The deregulated power industry meets the challenges of increase their profits and also minimize the associadted risks of the system. Themarket includes generating companies(Gencos and large Consumers. The demand prediction of the system has been determined by the neural network, which is trained by using the previous day demand dataset, the training process is achieved by the back propagation algorithm. The fitness of the system compared with PSO and ABC technique, the maximized fitness is the optimal bidding strategy of the system . The results for two techniques will be analyzed in this paper. The implementation of the two techniques could be implemented in theMATLAB Platform.

  16. Integrated preclinical photosafety testing strategy for systemically applied pharmaceuticals.

    Science.gov (United States)

    Schümann, Jens; Boudon, Stéphanie; Ulrich, Peter; Loll, Nathalie; Garcia, Déborah; Schaffner, René; Streich, Jeannine; Kittel, Birgit; Bauer, Daniel

    2014-05-01

    Phototoxic properties of systemically applied pharmaceuticals may be the cause of serious adverse drug reactions. Therefore, a reliable preclinical photosafety assessment strategy, combining in vitro and in vivo approaches in a quantitative manner, is important and has not been described so far. Here, we report the establishment of an optimized modified murine local lymph node assay (LLNA), adapted for phototoxicity assessment of systemically applied compounds, as well as the test results for 34 drug candidates in this in vivo photo-LLNA. The drug candidates were selected based on their ability to absorb ultraviolet/visible light and the photo irritation factors (PIFs) determined in the well-established in vitro 3T3 neutral red uptake phototoxicity test. An in vivo phototoxic potential was identified for 13 of these drug candidates. The use of multiple dose levels in the described murine in vivo phototoxicity studies enabled the establishment of no- and/or lowest-observed-adverse-effect levels (NOAELs/LOAELs), also supporting human photosafety assessment. An in vitro-in vivo correlation demonstrated that a drug candidate classified as "phototoxic" in vitro is not necessarily phototoxic in vivo. However, the probability for a drug candidate to cause phototoxicity in vivo clearly correlated with the magnitude of the phototoxicity identified in vitro.

  17. Estimating Wal-Mart's Impacts in Maryland: A Test of Identification Strategies and Endogeneity Tests

    OpenAIRE

    Michael J. Hicks

    2008-01-01

    In this paper, I estimate the impact of Wal-Mart on labor markets in Maryland. My goal is to compare estimation techniques that incorporate corrections for endogeneity of Wal-Mart's entrance and those that test for and fail to reject exogeneity in Wal-Mart's entrance decision. The instrumental variable approaches I test include those offered by Basker and Neumark et al., and a new test introduced in this paper. I also explain why differences in choice of sample time and location may lead to d...

  18. Test-set reduction in the screening step definition of a chiral separation strategy in polar organic solvents chromatography.

    Science.gov (United States)

    Ates, Hasret; Desmedt, Bart; Heyden, Yvan Vander

    2012-12-01

    The last decades, many efforts have been made to design and develop chiral separation strategies for different analytical techniques. To ensure that these strategies are broadly applicable rather large test-sets of molecules with very diverse molecules are used. The most enantioselective and complementary separation systems are then used as screening conditions in separation strategies. Potential changes in conditions e.g. implementation of new chiral selectors, requires screening of the entire set to retain the most enantioselective systems. A rational reduction of the test-sets may open new perspectives for developing and updating separation strategies. In the present work, it is investigated whether the screening step of an existing separation strategy in polar organic solvents chromatography can be reconstructed based on reduced test-set results Therefore, the structures of the 58 molecules of the test-set are digitally drawn and their optimal geometrical conformations calculated. From these conformations 3D-molecular descriptors are calculated. The test-set reduction is performed using the Kennard and Stone algorithm: compounds with the most diverse descriptors are selected. The test-sets are gradually reduced with 10% starting from 90% to 30% of the initial size. The results pointed out that with some reduced test-sets the same chromatographic systems are selected. A test-set reduction with 30% (41 remaining compounds) seems possible without losing information on the global enantioselectivity and complementarity of the tested chiral stationary phases.

  19. A three-stage strategy for optimal price offering by a retailer based on clustering techniques

    Energy Technology Data Exchange (ETDEWEB)

    Mahmoudi-Kohan, N.; Shayesteh, E. [Islamic Azad University (Garmsar Branch), Garmsar (Iran); Moghaddam, M. Parsa; Sheikh-El-Eslami, M.K. [Tarbiat Modares University, Tehran (Iran)

    2010-12-15

    In this paper, an innovative strategy for optimal price offering to customers for maximizing the profit of a retailer is proposed. This strategy is based on load profile clustering techniques and includes three stages. For the purpose of clustering, an improved weighted fuzzy average K-means is proposed. Also, in this paper a new acceptance function for increasing the profit of the retailer is proposed. The new method is evaluated by implementation on a group of 300 customers of a 20 kV distribution network. (author)

  20. Analyzing Classroom Strategy: Evaluating the Concept Mapping Technique at SSC Level in Pakistan

    Directory of Open Access Journals (Sweden)

    Sidra Mahmood

    2015-08-01

    Full Text Available This study documents the usage of Concept Mapping in the teaching-learning situation of English at SSC Level. The study is descriptive and analytical in nature and tries to investigate the effects which Concept Mapping renders in the academic environment in the context of ESL classroom setting. The research offers strategies for adopting certain techniques and up gradation of the content taught at the mentioned level by the inculcation of such techniques. Overall, the study produced a range of implementable outcomes by a pervasive discussion of Concept Mapping, the role of the textbooks, the importance of adding the technique to the contents of ESL classroom setting. For data collection and data analysis, two classes were selected. Both were taught the same content under controlled conditions. The concept mapping technique in the class guided the learners towards the improved way of learning the text of second language.

  1. RELIABILITY OF CERTAIN TESTS FOR EVALUATION OF JUDO TECHNIQUES

    Directory of Open Access Journals (Sweden)

    Slavko Obadov

    2007-05-01

    Full Text Available The sample included 106 judokas. Assessment of the level of mastership of judo techniques was carried out by evaluation of fi ve competent studies. Each subject performed a technique three times and each performance was evaluated by the judges. In order to evaluate measurement of each technique, Cronbach’s coeffi cient of reliability  was calculated. During the procedure the subjects's results were also transformed to factor scores i.e. the results of each performer at the main component of evaluation in the fi ve studies. These factor scores could be used in the subsequent procedure of multivariant statistical analysis.

  2. Barnes maze testing strategies with small and large rodent models.

    Science.gov (United States)

    Rosenfeld, Cheryl S; Ferguson, Sherry A

    2014-02-26

    Spatial learning and memory of laboratory rodents is often assessed via navigational ability in mazes, most popular of which are the water and dry-land (Barnes) mazes. Improved performance over sessions or trials is thought to reflect learning and memory of the escape cage/platform location. Considered less stressful than water mazes, the Barnes maze is a relatively simple design of a circular platform top with several holes equally spaced around the perimeter edge. All but one of the holes are false-bottomed or blind-ending, while one leads to an escape cage. Mildly aversive stimuli (e.g. bright overhead lights) provide motivation to locate the escape cage. Latency to locate the escape cage can be measured during the session; however, additional endpoints typically require video recording. From those video recordings, use of automated tracking software can generate a variety of endpoints that are similar to those produced in water mazes (e.g. distance traveled, velocity/speed, time spent in the correct quadrant, time spent moving/resting, and confirmation of latency). Type of search strategy (i.e. random, serial, or direct) can be categorized as well. Barnes maze construction and testing methodologies can differ for small rodents, such as mice, and large rodents, such as rats. For example, while extra-maze cues are effective for rats, smaller wild rodents may require intra-maze cues with a visual barrier around the maze. Appropriate stimuli must be identified which motivate the rodent to locate the escape cage. Both Barnes and water mazes can be time consuming as 4-7 test trials are typically required to detect improved learning and memory performance (e.g. shorter latencies or path lengths to locate the escape platform or cage) and/or differences between experimental groups. Even so, the Barnes maze is a widely employed behavioral assessment measuring spatial navigational abilities and their potential disruption by genetic, neurobehavioral manipulations, or drug

  3. Application of Molecular Diagnostic Techniques for Viral Testing

    OpenAIRE

    Cobo, Fernando

    2012-01-01

    Nucleic acid amplification techniques are commonly used currently to diagnose viral diseases and manage patients with this kind of illnesses. These techniques have had a rapid but unconventional route of development during the last 30 years, with the discovery and introduction of several assays in clinical diagnosis. The increase in the number of commercially available methods has facilitated the use of this technology in the majority of laboratories worldwide. This technology has reduced the...

  4. Analysis of Problem Solving Strategies on the Kohs Block Design Test.

    Science.gov (United States)

    Rozencwajg, Paulette

    1991-01-01

    Presents results of study investigating cognitive strategies involved in the Kohs Block Design test. Reports that the study's purposes were to improve the distinction between syncretic and analytic strategies, match strategies with field dependence level, and assess metacognitive skills. Discusses findings of three strategies: syncretic, analytic,…

  5. DC Microgrids – Part I: A Review of Control Strategies and Stabilization Techniques

    DEFF Research Database (Denmark)

    Dragicevic, Tomislav; Lu, Xiaonan; Quintero, Juan Carlos Vasquez;

    2016-01-01

    This paper presents a review of control strategies, stability analysis and stabilization techniques for DC microgrids (MGs). Overall control is systematically classified into local and coordinated control levels according to respective functionalities in each level. As opposed to local control...... which relies only on local measurements, some line of communication between units needs to be made available in order to achieve coordinated control. Depending on the communication method, three basic coordinated control strategies can be distinguished, i.e. decentralized, centralized and distributed...... control. Decentralized control can be regarded as an extension of local control since it is also based exclusively on local measurements. In contrast, centralized and distributed control strategies rely on digital communication technologies. A number of approaches to using these three coordinated control...

  6. Strategy Effects on Word Searching in Japanese Letter Fluency Tests: Evidence from the NIRS Findings

    Science.gov (United States)

    Hatta, Takeshi; Kanari, Ayano; Mase, Mitsuhito; Nagano, Yuko; Shirataki, Tatsuaki; Hibino, Shinji

    2009-01-01

    Strategy effects on word searching in the Japanese letter fluency test were investigated using the Near-infrared Spectroscopy (NIRS). Participants were given a Japanese letter fluency test and they were classified into two types of strategy users, based on analysis of their recorded verbal responses. One group, AIUEO-order strategy users, employed…

  7. Breast Cancer-Related Arm Lymphedema: Incidence Rates, Diagnostic Techniques, Optimal Management and Risk Reduction Strategies

    Energy Technology Data Exchange (ETDEWEB)

    Shah, Chirag [Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI (United States); Vicini, Frank A., E-mail: fvicini@beaumont.edu [Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI (United States)

    2011-11-15

    As more women survive breast cancer, long-term toxicities affecting their quality of life, such as lymphedema (LE) of the arm, gain importance. Although numerous studies have attempted to determine incidence rates, identify optimal diagnostic tests, enumerate efficacious treatment strategies and outline risk reduction guidelines for breast cancer-related lymphedema (BCRL), few groups have consistently agreed on any of these issues. As a result, standardized recommendations are still lacking. This review will summarize the latest data addressing all of these concerns in order to provide patients and health care providers with optimal, contemporary recommendations. Published incidence rates for BCRL vary substantially with a range of 2-65% based on surgical technique, axillary sampling method, radiation therapy fields treated, and the use of chemotherapy. Newer clinical assessment tools can potentially identify BCRL in patients with subclinical disease with prospective data suggesting that early diagnosis and management with noninvasive therapy can lead to excellent outcomes. Multiple therapies exist with treatments defined by the severity of BCRL present. Currently, the standard of care for BCRL in patients with significant LE is complex decongestive physiotherapy (CDP). Contemporary data also suggest that a multidisciplinary approach to the management of BCRL should begin prior to definitive treatment for breast cancer employing patient-specific surgical, radiation therapy, and chemotherapy paradigms that limit risks. Further, prospective clinical assessments before and after treatment should be employed to diagnose subclinical disease. In those patients who require aggressive locoregional management, prophylactic therapies and the use of CDP can help reduce the long-term sequelae of BCRL.

  8. Price leadership strategy or branding strategy:an empirical test of indigenous Chinese exporters

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    The effects of price leadership strategies and branding strategies on the export performance of indigenous Chinese exporters with a focus on developing country markets and developed country markets are examined based on the principles of strategy-environment co-alignment and marketing segmentation theory. Findings suggest that when focusing on developing country markets, the use of a branding strategy is more likely to enhance export performance. When focusing on developed country markets, neither the use o...

  9. A Strategy for Automatic Quality Signing and Verification Processes for Hardware and Software Testing

    Directory of Open Access Journals (Sweden)

    Mohammed I. Younis

    2010-01-01

    Circuits in a production line. Comparatively, our result demonstrates that the proposed strategy outperforms the traditional block partitioning strategy with the mutant score of 100% to 90%, respectively, with the same number of test cases.

  10. How well do test case prioritization techniques support statistical fault localization

    OpenAIRE

    Tse, TH; Jiang, B.; Zhang, Z; Chen, TY

    2009-01-01

    In continuous integration, a tight integration of test case prioritization techniques and fault-localization techniques may both expose failures faster and locate faults more effectively. Statistical fault-localization techniques use the execution information collected during testing to locate faults. Executing a small fraction of a prioritized test suite reduces the cost of testing, and yet the subsequent fault localization may suffer. This paper presents the first empirical study to examine...

  11. State of the art in non-animal approaches for skin sensitization testing: from individual test methods towards testing strategies.

    Science.gov (United States)

    Ezendam, Janine; Braakhuis, Hedwig M; Vandebriel, Rob J

    2016-12-01

    The hazard assessment of skin sensitizers relies mainly on animal testing, but much progress is made in the development, validation and regulatory acceptance and implementation of non-animal predictive approaches. In this review, we provide an update on the available computational tools and animal-free test methods for the prediction of skin sensitization hazard. These individual test methods address mostly one mechanistic step of the process of skin sensitization induction. The adverse outcome pathway (AOP) for skin sensitization describes the key events (KEs) that lead to skin sensitization. In our review, we have clustered the available test methods according to the KE they inform: the molecular initiating event (MIE/KE1)-protein binding, KE2-keratinocyte activation, KE3-dendritic cell activation and KE4-T cell activation and proliferation. In recent years, most progress has been made in the development and validation of in vitro assays that address KE2 and KE3. No standardized in vitro assays for T cell activation are available; thus, KE4 cannot be measured in vitro. Three non-animal test methods, addressing either the MIE, KE2 or KE3, are accepted as OECD test guidelines, and this has accelerated the development of integrated or defined approaches for testing and assessment (e.g. testing strategies). The majority of these approaches are mechanism-based, since they combine results from multiple test methods and/or computational tools that address different KEs of the AOP to estimate skin sensitization potential and sometimes potency. Other approaches are based on statistical tools. Until now, eleven different testing strategies have been published, the majority using the same individual information sources. Our review shows that some of the defined approaches to testing and assessment are able to accurately predict skin sensitization hazard, sometimes even more accurate than the currently used animal test. A few defined approaches are developed to provide an

  12. Analog and mixed signal test techniques for SoCs

    NARCIS (Netherlands)

    Kerkhoff, Hans G.; Kaminska, Bozena

    2003-01-01

    Submicron technologies, enabling the implementation of SoC's, are gaining acceptance and this represents a major step forward in design and test complexity. As a result, new tools and development flows are needed that will be able to handle the greater design and test challenges of increasingly smal

  13. European wind turbine procedure development blade test methods and techniques

    Energy Technology Data Exchange (ETDEWEB)

    Bulder, B.H.; Dam, J.J.D. van; Delft, D.R.V. van [and others

    1999-03-01

    In this paper the preliminary results obtained by performing the second task of the `European Wind Turbine Testing Procedure Development` project are presented. This project is performed within and with financial support of the Standards, Measurements and Testing programme of the European Commission. (au)

  14. A digital CDS technique and the performance testing

    CERN Document Server

    Liu, Xiao-Yan; Yang, Yan-Ji; Lu, Bo; Wang, Yu-Sa; Xu, Yu-Peng; Cui, Wei-Wei; Li, Wei; Li, Mao-Shun; Wang, Juan; Han, Da-Wei; Chen, Tian-Xiang; Huo, Jia; Hu, Wei; Zhang, Yi; Zhu, Yue; Zhang, Zi-Liang; Yin, Guo-He; Wang, Yu; Zhao, Zhong-Yi; Fu, Yan-Hong; Zhang, Ya; Ma, Ke-Yan; Chen, Yong

    2014-01-01

    Readout noise is a critical parameter for characterizing the performance of charge-coupled devices (CCDs), which can be greatly reduced by the correlated double sampling (CDS) circuit. However, conventional CDS circuit inevitably introduces new noises since it consists of several active analog components such as operational amplifiers. This paper proposes a digital CDS circuit technique, which transforms the pre-amplified CCD signal into a train of digital presentations by a high-speed data acquisition card directly without the noisy CDS circuit first, then implement the digital CDS algorithm through numerical method. The readout noise of 3.3 e$^{-}$ and the energy resolution of 121 eV@5.9keV can be achieved via the digital CDS technique.

  15. Identification of strategies to facilitate organ donation among African Americans using the nominal group technique.

    Science.gov (United States)

    Locke, Jayme E; Qu, Haiyan; Shewchuk, Richard; Mannon, Roslyn B; Gaston, Robert; Segev, Dorry L; Mannon, Elinor C; Martin, Michelle Y

    2015-02-06

    African Americans are disproportionately affected by ESRD, but few receive a living donor kidney transplant. Surveys assessing attitudes toward donation have shown that African Americans are less likely to express a willingness to donate their own organs. Studies aimed at understanding factors that may facilitate the willingness of African Americans to become organ donors are needed. A novel formative research method was used (the nominal group technique) to identify and prioritize strategies for facilitating increases in organ donation among church-attending African Americans. Four nominal group technique panel interviews were convened (three community and one clergy). Each community panel represented a distinct local church; the clergy panel represented five distinct faith-based denominations. Before nominal group technique interviews, participants completed a questionnaire that assessed willingness to become a donor; 28 African-American adults (≥19 years old) participated in the study. In total, 66.7% of participants identified knowledge- or education-related strategies as most important strategies in facilitating willingness to become an organ donor, a view that was even more pronounced among clergy. Three of four nominal group technique panels rated a knowledge-based strategy as the most important and included strategies, such as information on donor involvement and donation-related risks; 29.6% of participants indicated that they disagreed with deceased donation, and 37% of participants disagreed with living donation. Community participants' reservations about becoming an organ donor were similar for living (38.1%) and deceased (33.4%) donation; in contrast, clergy participants were more likely to express reservations about living donation (33.3% versus 16.7%). These data indicate a greater opposition to living donation compared with donation after one's death among African Americans and suggest that improving knowledge about organ donation, particularly

  16. An improved technique for oral administration of solutions of test ...

    African Journals Online (AJOL)

    STORAGESEVER

    2009-03-20

    Mar 20, 2009 ... The oral administration of solution of drugs or test substances to experimental rats is often necessary in various pharmacological, toxicological and other biomedical ... procedure to avoid damage to it from the animal's bite.

  17. Tests of absorbents and solidification techniques for oil wastes

    Energy Technology Data Exchange (ETDEWEB)

    Lin, M.; MacKenzie, D. R.

    1983-11-01

    A representative of each of six classes of commonly used adsorbents was chosen for a series of tests. After reviewing ASTM and other related standard tests, uncomplicated procedures were developed for carrying out specific tests to determine absorbency for simulated oil waste and for water, under static and simulated transportation (repetitive shock) conditions. The tests were then applied to the six representative absorbents. Solidification tests were performed using these absorbents saturated with oil and loaded to 50% of saturation. The binders used were Portland I cement and Delaware Custom Material (DCM) cement shale silicate. Samples were checked for proper set, and the amounts of free liquid were measured. Another series of tests was performed on samples of simulated oil waste without absorbent, using Portland cement and DCM cement shale silicate. Samples were checked for proper set, free liquid was measured, and compressive strengths were determined. The state-of-the-art parameters were identified which satisfy NRC disposal criteria for solidified radioactive waste. The literature was reviewed for alternative methods of managing oil wastes. Conclusions are drawn on the relative utility of the various methods. 17 references, 3 tables.

  18. Effects of a test taking strategy on postsecondary computer assisted chemistry assessments

    Science.gov (United States)

    Manco, Sharon Ann

    Metacognitive test taking strategies have proven advantageous in improving content-based test scores in a wide variety of disciplines and age/grade levels using traditional paper-and-pencil tests. However, despite the increase in computer assisted assessment (CAA), little research has examined whether these test taking strategies are effective for computer assisted tests. Research was conducted to determine if learning a proven test taking strategy would improve the online quiz scores of six university students in an introductory chemistry course intended for science, technology, engineering and math majors. Participants completed six to ten chemistry quizzes prior to intervention---learning the test taking strategy---and four to eight chemistry quizzes after intervention. Results indicated that, while students learned the strategy, it had little effect on their online chemistry quiz scores. Additionally, at the end of the semester, participants completed a satisfaction survey indicating general satisfaction with having learned the test taking strategy and generalization to other courses and types of tests. Furthermore, results suggest that adaptations to the on-line delivery method of the quizzes and to the test taking strategies may improve the robustness of the effect. Due to the increased use of computer assisted assessment, additional research is warranted to determine appropriate test taking strategies for online tests.

  19. The Testing Effect: Illustrating a Fundamental Concept and Changing Study Strategies

    Science.gov (United States)

    Einstein, Gilles O.; Mullet, Hillary G.; Harrison, Tyler L.

    2012-01-01

    An important recent finding is that testing improves learning and memory. In this article, the authors describe a demonstration that illustrates this principle and helps students incorporate more testing into their learning. The authors asked students to read one text using a Study-Study strategy and one text using a Study-Test strategy. One week…

  20. Strategy for genotoxicity testing: hazard identification and risk assessment in relation to in vitro testing.

    Science.gov (United States)

    Thybaud, V; Aardema, M; Clements, J; Dearfield, K; Galloway, S; Hayashi, M; Jacobson-Kram, D; Kirkland, D; MacGregor, J T; Marzin, D; Ohyama, W; Schuler, M; Suzuki, H; Zeiger, E

    2007-02-03

    This report summarizes the proceedings of the September 9-10, 2005 meeting of the Expert Working Group on Hazard Identification and Risk Assessment in Relation to In Vitro Testing, part of an initiative on genetic toxicology. The objective of the Working Group was to develop recommendations for interpretation of results from tests commonly included in regulatory genetic toxicology test batteries, and to propose an appropriate strategy for follow-up testing when positive in vitro results were obtained in these assays. The Group noted the high frequency of positive in vitro findings in the genotoxicity test batteries with agents found not to be carcinogenic and thought not to pose a carcinogenic health hazard to humans. The Group agreed that a set of consensus principles for appropriate interpretation and follow-up testing when initial in vitro tests are positive was needed. Current differences in emphasis and policy among different regulatory agencies were recognized as a basis of this need. Using a consensus process among a balanced group of recognized international authorities from industry, government, and academia, it was agreed that a strategy based on these principles should include guidance on: (1) interpretation of initial results in the "core" test battery; (2) criteria for determining when follow-up testing is needed; (3) criteria for selecting appropriate follow-up tests; (4) definition of when the evidence is sufficient to define the mode of action and the relevance to human exposure; and (5) definition of approaches to evaluate the degree of health risk under conditions of exposure of the species of concern (generally the human). A framework for addressing these issues was discussed, and a general "decision tree" was developed that included criteria for assessing the need for further testing, selecting appropriate follow-up tests, and determining a sufficient weight of evidence to attribute a level of risk and stop testing. The discussion included case

  1. Group techniques as a methodological strategy in acquiring teamwork abilities by college students

    Directory of Open Access Journals (Sweden)

    César Torres Martín

    2013-02-01

    Full Text Available From the frame of the European Higher Education Space an adaptation of teaching-learning process is being promoted by means of the pedagogical renewal, introducing into the class a major number of active or participative methodologies in order to provide students with a major autonomy in said process. This requires taking into account the incorporation of basic skills within university curriculum, especially “teamwork”. By means of group techniques students can acquire interpersonal and cognitive skills, as well as abilities that will enable them to face different group situations throughout their academic and professional career. These techniques are necessary not only as a methodological strategy in the classroom, but also as a reflection instrument for students to assess their behavior in group, with an aim to modify conduct strategies that make that relationship with others influences their learning process. Hence the importance of this ability to sensitize students positively for collective work. Thus using the research-action method in the academic classroom during one semester and making systematic intervention with different group techniques, we manage to present obtained results by means of an analysis of the qualitative data, where the selected instruments are group discussion and personal reflection.

  2. A New V2G Control Strategy for Load Factor Improvement Using Smoothing Technique

    Directory of Open Access Journals (Sweden)

    CHANHOM, P.

    2017-08-01

    Full Text Available This paper proposes a new vehicle-to-grid (V2G control strategy for improving the load factor in the power network. To operate the proposed strategy, the available storage capacity of the PEVs’ batteries is considered as a battery energy storage system (BESS for charging and discharging an amount of power corresponding to the V2G power command. Due to the remarkable advantages of the technique so-called simple moving average, it is selected for applying in the proposed V2G control strategy. In this research, for investigating the load factor improvement, the essential data including the daily-load profiles with 7-day and 14-day periods are used for the 3 studied cases. These 3 studied cases present the power network with variation of the PEVs locations for describing the PEVs usage and charging or discharging behavior. The performance of the proposed strategy is simulated and verified by the MATPOWER software. The simulation results show that the load factors of the 3 studied cases are improved. Moreover, the encouragement of energy arbitrage for the PEVs owners is also discussed in this paper.

  3. Nondestructive testing: the techniques in work; CND: les techniques en piste

    Energy Technology Data Exchange (ETDEWEB)

    Anon

    2008-05-15

    In the framework of the Toulouse Cofrend days, the developments of the nondestructive methods are presented as well as the new needs of the manufacturers for applications. Several techniques are detailed: acoustic emission, phased array, time of flight diffraction and numerical radiography. (O.M.)

  4. Software Test Appliance Techniques (STAT) for Software Systems

    Science.gov (United States)

    2011-05-01

    switch R d l li d– e uce contro coup ng, re uce test cases CMMI-ML3 • Prevent bugs in software and hardware before deployment. • Discover ...TORQUE AVAILABLE (Dual): 1 ( ! .... 1788 M.6X TORQUE AVAILABLE (S ingle *f. J ... 1789 M.6X TORQUE AVAILABLE (Single *f: j .. 8307 MIN SE - lAS- W

  5. Strategies for Ground Based Testing of Manned Lunar Surface Systems

    Science.gov (United States)

    Beyer, Jeff; Peacock, Mike; Gill, Tracy

    2009-01-01

    Integrated testing (such as Multi-Element Integrated Test (MEIT)) is critical to reducing risks and minimizing problems encountered during assembly, activation, and on-orbit operation of large, complex manned spacecraft. Provides the best implementation of "Test Like You Fly:. Planning for integrated testing needs to begin at the earliest stages of Program definition. Program leadership needs to fully understand and buy in to what integrated testing is and why it needs to be performed. As Program evolves and design and schedules mature, continually look for suitable opportunities to perform testing where enough components are together in one place at one time. The benefits to be gained are well worth the costs.

  6. Artificial intelligence techniques for ground test monitoring of rocket engines

    Science.gov (United States)

    Ali, Moonis; Gupta, U. K.

    1990-01-01

    An expert system is being developed which can detect anomalies in Space Shuttle Main Engine (SSME) sensor data significantly earlier than the redline algorithm currently in use. The training of such an expert system focuses on two approaches which are based on low frequency and high frequency analyses of sensor data. Both approaches are being tested on data from SSME tests and their results compared with the findings of NASA and Rocketdyne experts. Prototype implementations have detected the presence of anomalies earlier than the redline algorithms that are in use currently. It therefore appears that these approaches have the potential of detecting anomalies early eneough to shut down the engine or take other corrective action before severe damage to the engine occurs.

  7. Teachers and Learners’ Perceptions of Applying Translation as a Method, Strategy, or Technique in an Iranian EFL Setting

    Directory of Open Access Journals (Sweden)

    Fatemeh Mollaei

    2017-04-01

    Full Text Available It has been found that translation is an efficient means to teach/learn grammar, syntax, and lexis of a foreign language. Meanwhile, translation is good for beginners who do not still enjoy the critical level of proficiency in their target language for expression.  This study was conducted to examine the teachers and learners’ perceptions of employing translation in the foreign language classroom; i.e., the effects, merits, demerits, limitations, as well as its use as a method, strategy or technique. Both quantitative and qualitative methods were used to collect and analyze the data from graduate and undergraduate learners (n=56 and teachers (n=44, male and female, who responded to two questionnaires. Additionally, only the teachers were interviewed to gain richer insight into their perceptions and attitudes. According to the results of independent samples t-test, there was no significant difference between teachers and learners’ attitude to applying translation as a method, strategy, or technique in learning a foreign language.  Based on the interview results, some teachers believed that employing translation in the foreign language context was helpful but not constantly. They claimed that translation was only effective in teaching vocabulary and grammar apart from leaners’ proficiency level as it can clarify meaning. But some other teachers noted that mother tongue would interfere with learning foreign language; they considered translation as a time-consuming activity through which students cannot capture the exact meaning.

  8. Concepts, tools, and strategies for effluent testing: An international survey

    Science.gov (United States)

    Whole effluent testing (also called Direct Toxicity Assessment) remains a critical long-term assessment tool for aquatic environmental protection. Use of animal alternative approaches for wastewater testing is expected to increase as more regulatory authorities routinely require ...

  9. Testing - Smart strategy for safety and mission quality

    Science.gov (United States)

    Rodney, George A.

    The paper is concerned with the need for a comprehensive test plan for the Space Station Freedom (SST) that would fully verify specification compliance and be based on an error budget. In particular, attention is given to some lessons learned from other NASA programs and the principal challenges for SSF testing, including phase C/D/E agreements, testing parameters, phase testing, and the human element. The importance of close teamwork between the NASA/Contractor systems engineers and assurance engineers is emphasized.

  10. Teaching Posttraining : Influencing Diagnostic Strategy with Instructions at Test

    Science.gov (United States)

    Kulatunga-Moruzi, Chan; Brooks, Lee R.; Norman, Geoffrey R.

    2011-01-01

    It is believed that medical diagnosis involves two complementary processes, analytic and similarity-based. There is considerable debate as to which of these processes defines diagnostic expertise and how best to teach clinical diagnosis and reduce diagnostic errors. The purpose of these studies is to document the use of these strategies in medical…

  11. Teaching Posttraining : Influencing Diagnostic Strategy with Instructions at Test

    Science.gov (United States)

    Kulatunga-Moruzi, Chan; Brooks, Lee R.; Norman, Geoffrey R.

    2011-01-01

    It is believed that medical diagnosis involves two complementary processes, analytic and similarity-based. There is considerable debate as to which of these processes defines diagnostic expertise and how best to teach clinical diagnosis and reduce diagnostic errors. The purpose of these studies is to document the use of these strategies in medical…

  12. Current techniques and strategies for anesthesia in patients undergoing peripheral bypass surgery.

    Science.gov (United States)

    Bouman, E; Dortangs, E; Buhre, W; Gramke, H F

    2014-04-01

    Peripheral arterial disease is an illness with a high prevalence in Europe and North America. The disease is associated with a significant impact on quality of life. Despite advanced medical and endovascular treatments, surgery is often indicated to prevent the consequences of ischemic injury. Usually, these patients do have significant comorbidities resulting in an increased risk for anesthesia-related complications. While general anesthesia is commonly used for the majority of the patients, local and regional anesthesia (RA) offer several possible advantages such as stable cardiovascular hemodynamic perioperative course, improved postoperative pain relief and prevention of chronic postsurgical pain syndromes. This review will discuss perioperative management, available evidence regarding general anesthesia and various regional anesthetic techniques for peripheral vascular surgery, and the current advises regarding anticoagulants and RA. No definitive conclusions can be drawn from the existing literature with respect to superiority of general or neuraxial anesthesia or even RA. Maybe the profits lie in the combination of techniques, a strategy, to overcome the risks of one and use the benefits of the other technique. From circumstantial evidence, it is most likely that the experience of the anesthetic and surgical team is one of the major determinants of perioperative complications independent from the individual anesthesia technique.

  13. Mobile Software Testing: Thoughts, Strategies, Challenges, and Experimental Study

    Directory of Open Access Journals (Sweden)

    Mohammed Akour

    2016-06-01

    Full Text Available Mobile devices have become more pervasive in our daily lives, and are gradually replacing regular computers to perform traditional processes like Internet browsing, editing photos, playing videos and sound track, and reading different files. The importance of mobile devices in our life necessitates more concerns of the reliability and compatibility of mobile applications, and thus, testing these applications arises as an important phase in mobile devices adaption process. This paper addressed various research directions on mobile applications testing by investigating essential concepts, scope, features and requirements for testing mobile application. We highlight the similarities and the differences between mobile APP testing and mobile web testing. Furthermore, we discuss and compare different mobile testing approaches and environments, and provide the challenges as emergent needs in test environments. As a case study, we compared the testing experience of hybrid application in an emulator and a real world device. The purpose of the experiment is to verify to which extent a virtual device can emulate a complete client experience. Set of experiments are conducted where five android mobile browsers are tested. Each browser will be on a real device as well as an emulated device with the same features (CPU used, memory size, etc. The application will be tested on the following metrics: Performance and function/behavior testing.

  14. Development of structural health monitoring techniques using dynamics testing

    Energy Technology Data Exchange (ETDEWEB)

    James, G.H. III [Sandia National Labs., Albuquerque, NM (United States). Experimental Structural Dynamics Dept.

    1996-03-01

    Today`s society depends upon many structures (such as aircraft, bridges, wind turbines, offshore platforms, buildings, and nuclear weapons) which are nearing the end of their design lifetime. Since these structures cannot be economically replaced, techniques for structural health monitoring must be developed and implemented. Modal and structural dynamics measurements hold promise for the global non-destructive inspection of a variety of structures since surface measurements of a vibrating structure can provide information about the health of the internal members without costly (or impossible) dismantling of the structure. In order to develop structural health monitoring for application to operational structures, developments in four areas have been undertaken within this project: operational evaluation, diagnostic measurements, information condensation, and damage identification. The developments in each of these four aspects of structural health monitoring have been exercised on a broad range of experimental data. This experimental data has been extracted from structures from several application areas which include aging aircraft, wind energy, aging bridges, offshore structures, structural supports, and mechanical parts. As a result of these advances, Sandia National Laboratories is in a position to perform further advanced development, operational implementation, and technical consulting for a broad class of the nation`s aging infrastructure problems.

  15. Comprehensive In Vitro Toxicity Testing of a Panel of Representative Oxide Nanomaterials: First Steps towards an Intelligent Testing Strategy.

    Directory of Open Access Journals (Sweden)

    Lucian Farcal

    Full Text Available Nanomaterials (NMs display many unique and useful physico-chemical properties. However, reliable approaches are needed for risk assessment of NMs. The present study was performed in the FP7-MARINA project, with the objective to identify and evaluate in vitro test methods for toxicity assessment in order to facilitate the development of an intelligent testing strategy (ITS. Six representative oxide NMs provided by the EC-JRC Nanomaterials Repository were tested in nine laboratories. The in vitro toxicity of NMs was evaluated in 12 cellular models representing 6 different target organs/systems (immune system, respiratory system, gastrointestinal system, reproductive organs, kidney and embryonic tissues. The toxicity assessment was conducted using 10 different assays for cytotoxicity, embryotoxicity, epithelial integrity, cytokine secretion and oxidative stress. Thorough physico-chemical characterization was performed for all tested NMs. Commercially relevant NMs with different physico-chemical properties were selected: two TiO2 NMs with different surface chemistry - hydrophilic (NM-103 and hydrophobic (NM-104, two forms of ZnO - uncoated (NM-110 and coated with triethoxycapryl silane (NM-111 and two SiO2 NMs produced by two different manufacturing techniques - precipitated (NM-200 and pyrogenic (NM-203. Cell specific toxicity effects of all NMs were observed; macrophages were the most sensitive cell type after short-term exposures (24-72h (ZnO>SiO2>TiO2. Longer term exposure (7 to 21 days significantly affected the cell barrier integrity in the presence of ZnO, but not TiO2 and SiO2, while the embryonic stem cell test (EST classified the TiO2 NMs as potentially 'weak-embryotoxic' and ZnO and SiO2 NMs as 'non-embryotoxic'. A hazard ranking could be established for the representative NMs tested (ZnO NM-110 > ZnO NM-111 > SiO2 NM-203 > SiO2 NM-200 > TiO2 NM-104 > TiO2 NM-103. This ranking was different in the case of embryonic tissues, for which TiO2

  16. Comparing face processing strategies between typically-developed observers and observers with autism using sub-sampled-pixels presentation in response classification technique.

    Science.gov (United States)

    Nagai, Masayoshi; Bennett, Patrick J; Rutherford, M D; Gaspar, Carl M; Kumada, Takatsune; Sekuler, Allison B

    2013-03-07

    In the present study we modified the standard classification image method by subsampling visual stimuli to provide us with a technique capable of examining an individual's face-processing strategy in detail with fewer trials. Experiment 1 confirmed that one testing session (1450 trials) was sufficient to produce classification images that were qualitatively similar to those obtained previously with 10,000 trials (Sekuler et al., 2004). Experiment 2 used this method to compare classification images obtained from observers with autism spectrum disorders (ASD) and typically-developing (TD) observers. As was found in Experiment 1, classification images obtained from TD observers suggested that they all discriminated faces based on information conveyed by pixels in the eyes/brow region. In contrast, classification images obtained from ASD observers suggested that they used different perceptual strategies: three out of five ASD observers used a typical strategy of making use of information in the eye/brow region, but two used an atypical strategy that relied on information in the forehead region. The advantage of using the response classification technique is that there is no restriction to specific theoretical perspectives or a priori hypotheses, which enabled us to see unexpected strategies, like ASD's forehead strategy, and thus showed this technique is particularly useful in the examination of special populations.

  17. Technique for Outdoor Test on Concentrating Photovoltaic Cells

    Directory of Open Access Journals (Sweden)

    Paola Sansoni

    2015-01-01

    Full Text Available Outdoor experimentation of solar cells is essential to maximize their performance and to assess utilization requirements and limits. More generally tests with direct exposure to the sun are useful to understand the behavior of components and new materials for solar applications in real working conditions. Insolation and ambient factors are uncontrollable but can be monitored to know the environmental situation of the solar exposure experiment. A parallel characterization of the photocells can be performed in laboratory under controllable and reproducible conditions. A methodology to execute solar exposure tests is proposed and practically applied on photovoltaic cells for a solar cogeneration system. The cells are measured with concentrated solar light obtained utilizing a large Fresnel lens mounted on a sun tracker. Outdoor measurements monitor the effects of the exposure of two multijunction photovoltaic cells to focused sunlight. The main result is the continuous acquisition of the V-I (voltage-current curve for the cells in different conditions of solar concentration and temperature of exercise to assess their behavior. The research investigates electrical power extracted, efficiency, temperatures reached, and possible damages of the photovoltaic cell.

  18. The Interaction between Cognitive Test-Taking Strategies, Reading Ability, and Reading Comprehension Test Performance of Iranian EFL Learners

    Science.gov (United States)

    Ghafournia, Narjes; Afghari, Akbar

    2013-01-01

    The study scrutinized the probable interaction between using cognitive test-taking strategies, reading proficiency, and reading comprehension test performance of Iranian postgraduate students, who studied English as a foreign language. The study also probed the extent to which the participants' test performance was related to the use of certain…

  19. Testing Strategies and Methodologies for the Max Launch Abort System

    Science.gov (United States)

    Schaible, Dawn M.; Yuchnovicz, Daniel E.

    2011-01-01

    The National Aeronautics and Space Administration (NASA) Engineering and Safety Center (NESC) was tasked to develop an alternate, tower-less launch abort system (LAS) as risk mitigation for the Orion Project. The successful pad abort flight demonstration test in July 2009 of the "Max" launch abort system (MLAS) provided data critical to the design of future LASs, while demonstrating the Agency s ability to rapidly design, build and fly full-scale hardware at minimal cost in a "virtual" work environment. Limited funding and an aggressive schedule presented a challenge for testing of the complex MLAS system. The successful pad abort flight demonstration test was attributed to the project s systems engineering and integration process, which included: a concise definition of, and an adherence to, flight test objectives; a solid operational concept; well defined performance requirements, and a test program tailored to reducing the highest flight test risks. The testing ranged from wind tunnel validation of computational fluid dynamic simulations to component ground tests of the highest risk subsystems. This paper provides an overview of the testing/risk management approach and methodologies used to understand and reduce the areas of highest risk - resulting in a successful flight demonstration test.

  20. Design of a testing strategy using non-animal based test methods: lessons learnt from the ACuteTox project.

    Science.gov (United States)

    Kopp-Schneider, Annette; Prieto, Pilar; Kinsner-Ovaskainen, Agnieszka; Stanzel, Sven

    2013-06-01

    In the framework of toxicology, a testing strategy can be viewed as a series of steps which are taken to come to a final prediction about a characteristic of a compound under study. The testing strategy is performed as a single-step procedure, usually called a test battery, using simultaneously all information collected on different endpoints, or as tiered approach in which a decision tree is followed. Design of a testing strategy involves statistical considerations, such as the development of a statistical prediction model. During the EU FP6 ACuteTox project, several prediction models were proposed on the basis of statistical classification algorithms which we illustrate here. The final choice of testing strategies was not based on statistical considerations alone. However, without thorough statistical evaluations a testing strategy cannot be identified. We present here a number of observations made from the statistical viewpoint which relate to the development of testing strategies. The points we make were derived from problems we had to deal with during the evaluation of this large research project. A central issue during the development of a prediction model is the danger of overfitting. Procedures are presented to deal with this challenge. Copyright © 2012 Elsevier Ltd. All rights reserved.

  1. A strategy to couple the material point method (MPM) and smoothed particle hydrodynamics (SPH) computational techniques

    Science.gov (United States)

    Raymond, Samuel J.; Jones, Bruce; Williams, John R.

    2016-12-01

    A strategy is introduced to allow coupling of the material point method (MPM) and smoothed particle hydrodynamics (SPH) for numerical simulations. This new strategy partitions the domain into SPH and MPM regions, particles carry all state variables and as such no special treatment is required for the transition between regions. The aim of this work is to derive and validate the coupling methodology between MPM and SPH. Such coupling allows for general boundary conditions to be used in an SPH simulation without further augmentation. Additionally, as SPH is a purely particle method, and MPM is a combination of particles and a mesh. This coupling also permits a smooth transition from particle methods to mesh methods, where further coupling to mesh methods could in future provide an effective farfield boundary treatment for the SPH method. The coupling technique is introduced and described alongside a number of simulations in 1D and 2D to validate and contextualize the potential of using these two methods in a single simulation. The strategy shown here is capable of fully coupling the two methods without any complicated algorithms to transform information from one method to another.

  2. An Investigation of the Learning Strategies as Bias Factors in Second Language Cloze Tests

    Science.gov (United States)

    Ajideh, Parviz; Yaghoubi-Notash, Massoud; Khalili, Abdolreza

    2017-01-01

    The present study investigated the contribution of the EFL students' learning strategies to the explanation of the variance in their results on language tests. More specifically, it examined the role of these strategies as bias factors in the results of English cloze tests. Based on this aim, first, 158 intermediate EFL learners were selected from…

  3. Surgical technique for heart transplantation: a strategy for congenital heart disease.

    Science.gov (United States)

    Hosseinpour, Amir-Reza; González-Calle, Antonio; Adsuar-Gómez, Alejandro; Cuerpo, Gregorio; Greco, Rubén; Borrego-Domínguez, José Miguel; Ordoñez, Antonio; Wallwork, John

    2013-10-01

    The standard techniques for orthotopic heart transplantation often require certain adjustments when the procedure is carried out for complex congenital heart disease. This is because of both the unusual anatomy and possible distortions caused by previous surgery. Such technical adjustments have been described in various published reports over the years. Those reports, when combined, do cover the full spectrum of the technical difficulties that may be encountered, whether the defects are in their original form or altered by surgery, such that no cardiac malformation or distortion would prohibit transplantation. However, those reports are comprehensive only when combined. None of the individual reports addresses all the possible technical challenges. Consequently, the available information is somewhat fragmented. In addition, the generic aspect of the described technical strategies is not always given the emphasis that it deserves. Indeed, occasionally a technique may be presented as a specific solution for a specific malformation, without necessarily pointing out that the same technique may be applied to other hearts with different overall pathologies but which share that specific malformation. The aim of this review article was to combine all the available published information in one article in a manner that constructs a simple but comprehensive and generic system of decision-making that may be applied to any heart in order to determine the exact technical adjustments needed for transplantation in each case. Such a strategy is possible for two reasons. First, only a few anatomical sites are technically significant, namely the points of anastomosis between the donor's organ and the recipient. The rest of the intracardiac morphology does not affect the operation and may be ignored. Second, each of those anatomical sites can present difficulties in only a few ways, and each of those few difficulties has a well-described and published solution already. Therefore, the

  4. Ranking of ecotoxisity tests for underground water assessment using the Hasse diagram technique.

    Science.gov (United States)

    Kudłak, Błażej; Tsakovski, Stefan; Simeonov, Vasil; Sagajdakow, Agnieszka; Wolska, Lidia; Namieśnik, Jacek

    2014-01-01

    The present study deals with the novel application of the Hasse diagram technique (HDT) for the specific ranking of ecotoxicity tests capable of assessment of underground water quality. The area studied is a multi-municipal landfill in the northern Poland. The monitoring network of the landfill constitutes of 27 piezometers for underground water monitoring and two observation points at surface water courses. After sampling, chemical analysis of various water parameters was performed (pH, conductivity, temperature, turbidity (TURB), color, taste, smell and atmospheric conditions: temperature, precipitation and cloud cover, heavy metals content (Cu, Zn, Pb, Cd, Cr(6+), Hg), total organic carbon (TOC), sum of Polycyclic Aromatic Hydrocarbons (PAHs), Na, Mg, K, Ca, Mn, Fe, Ni, alkalinity (Alkal), general hardness, total suspended matter (SUSP), Biological Oxygen Demand (BOD), Chemical Oxygen Demand (COD), chlorides, fluorides, sulphides, sulphates, ammonium nitrogen, total nitrogen, nitrate and nitrite nitrogen, volatile phenols, ether extracts (ETHER), dry residues (DRY_RES), dissolved compounds). Parallel to the chemical parameters assessment six different ecotoxicity tests were applied (% root length(PG)/germination(PR) inhibition of Sorghum saccharatum (respectively PGSS/PRSS), Sinapis alba (respectively PGSA/PRSA), Lepidium sativum (respectively PGLS/PRLS), % bioluminescence inhibition of Vibrio fischeri (MT), % mortality of Daphnia magna (DM), % mortality of Thamnocephalus platyrus (TN)). In order to determine the applicability of the various ecotoxicity tests, a ranking of samples from different monitoring levels according to the test used (attributes) is done by using HDT. Further, the sensitivity of the biotests was determined and compared. From the sensitivity analysis of the both monitoring levels was evident that the choice of ecotoxicity tests could be optimized by the use of HDT strategy. Most reliable results could be expected by the application of root

  5. Automated detection of test fixture strategies and smells

    NARCIS (Netherlands)

    Greiler, M.S.; Van Deursen, A.; Storey, M.-A.

    2013-01-01

    Paper accepted for publication in the Proceedings of the Sixth International Conference on Software Testing, Verification and Validation, IEEE Computer Society, 18-22 March 2013, ISBN 978-1-4673-5961-0, doi: 10.1109/ICST.2013.45 Designing automated tests is a challenging task. One important concern

  6. Automated detection of test fixture strategies and smells

    NARCIS (Netherlands)

    Greiler, M.S.; Van Deursen, A.; Storey, M.-A.

    2013-01-01

    Paper accepted for publication in the Proceedings of the Sixth International Conference on Software Testing, Verification and Validation, IEEE Computer Society, 18-22 March 2013, ISBN 978-1-4673-5961-0, doi: 10.1109/ICST.2013.45 Designing automated tests is a challenging task. One important concern

  7. Reading for Academic Purposes: Techniques and Strategies to help Angolan ELT Students at ISCED-Benguela enhance their Reading Skills

    OpenAIRE

    Lolino, António

    2014-01-01

    This paper examines academic reading difficulties Angolan second year ELT students have at ISCED (Instituto Superior de Ciências da Educação) in Benguela and focuses on a variety of reading strategies and techniques as well as models for reading materials to help improve academic reading skills. Finally, it recommends the use of appropriate reading strategies and techniques, materials, and the adoption of a more student-centred approach in teaching reading to encourage the development of a re...

  8. Flight testing techniques for the evaluation of light aircraft stability derivatives: A review and analysis

    Science.gov (United States)

    Smetana, F. O.; Summery, D. C.; Johnson, W. D.

    1972-01-01

    Techniques quoted in the literature for the extraction of stability derivative information from flight test records are reviewed. A recent technique developed at NASA's Langley Research Center was regarded as the most productive yet developed. Results of tests of the sensitivity of this procedure to various types of data noise and to the accuracy of the estimated values of the derivatives are reported. Computer programs for providing these initial estimates are given. The literature review also includes a discussion of flight test measuring techniques, instrumentation, and piloting techniques.

  9. Non-destructive-Testing of Nuclear Fuel Element by Means of Neutron Imaging Technique

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Nuclear fuel element is the key component of nuclear reactor. People have to make strictly testing of the element to make sure the reactor operating safely. Neutron imaging is one of Non-destructive-Testing (NDT) techniques, which are very important techniques for

  10. Applications of NLP Techniques to Computer-Assisted Authoring of Test Items for Elementary Chinese

    Science.gov (United States)

    Liu, Chao-Lin; Lin, Jen-Hsiang; Wang, Yu-Chun

    2010-01-01

    The authors report an implemented environment for computer-assisted authoring of test items and provide a brief discussion about the applications of NLP techniques for computer assisted language learning. Test items can serve as a tool for language learners to examine their competence in the target language. The authors apply techniques for…

  11. A combined analytical-experimental tensile test technique for brittle materials

    Science.gov (United States)

    Chu, M. L.; Scavuzzo, R. J.; Srivatsan, T. S.

    1992-01-01

    A semiconventional tensile test technique is developed for impact ices and other brittle materials. Accurate results have been obtained on ultimate strength and modulus of elasticity in a refrigerated ice test. It is noted that the technique can be used to determine the physical properties of impact ices accreted inside icing wind tunnels or other brittle materials.

  12. Practical aspects of mutagenicity testing strategy: an industrial perspective.

    Science.gov (United States)

    Gollapudi, B B; Krishna, G

    2000-11-20

    Genetic toxicology studies play a central role in the development and marketing of new chemicals for pharmaceutical, agricultural, industrial, and consumer use. During the discovery phase of product development, rapid screening tests that require minimal amounts of test materials are used to assist in the design and prioritization of new molecules. At this stage, a modified Salmonella reverse mutation assay and an in vitro micronucleus test with mammalian cell culture are frequently used for screening. Regulatory genetic toxicology studies are conducted with a short list of compounds using protocols that conform to various international guidelines. A set of four assays usually constitutes the minimum test battery that satisfies global requirements. This set includes a bacterial reverse mutation assay, an in vitro cytogenetic test with mammalian cell culture, an in vitro gene mutation assay in mammalian cell cultures, and an in vivo rodent bone marrow micronucleus test. Supplementary studies are conducted in certain instances either as a follow-up to the findings from this initial testing battery and/or to satisfy a regulatory requirement. Currently available genetic toxicology assays have helped the scientific and industrial community over the past several decades in evaluating the mutagenic potential of chemical agents. The emerging field of toxicogenomics has the potential to redefine our ability to study the response of cells to genetic damage and hence our ability to study threshold phenomenon.

  13. Dynamic Test Case Design Scenario and analysis of Module Testing Using Manual vs. Automated Technique

    OpenAIRE

    Er. RAJENDER KUMAR; Dr. M.K.GUPTA

    2012-01-01

    Software can be tested either manually or automatically.The two approaches are complementary: automated testingcan perform a huge number of tests in short time or period,whereas manual testing uses the knowledge of the testingengineer to target testing to the parts of the system that areassumed to be more error-prone. Despite this contemporary,tools for manual and automatic testing are usually different,leading to decreased productivity and reliability of thetesting process. AutoTest is a tes...

  14. Adaptive and qualitative changes in encoding strategy with experience: evidence from the test-expectancy paradigm.

    Science.gov (United States)

    Finley, Jason R; Benjamin, Aaron S

    2012-05-01

    Three experiments demonstrated learners' abilities to adaptively and qualitatively accommodate their encoding strategies to the demands of an upcoming test. Stimuli were word pairs. In Experiment 1, test expectancy was induced for either cued recall (of targets given cues) or free recall (of targets only) across 4 study-test cycles of the same test format, followed by a final critical cycle featuring either the expected or the unexpected test format. For final tests of both cued and free recall, participants who had expected that test format outperformed those who had not. This disordinal interaction, supported by recognition and self-report data, demonstrated not mere differences in effort based on anticipated test difficulty, but rather qualitative and appropriate differences in encoding strategies based on expected task demands. Participants also came to appropriately modulate metacognitive monitoring (Experiment 2) and study-time allocation (Experiment 3) across study-test cycles. Item and associative recognition performance, as well as self-report data, revealed shifts in encoding strategies across trials; these results were used to characterize and evaluate the different strategies that participants employed for cued versus free recall and to assess the optimality of participants' metacognitive control of encoding strategies. Taken together, these data illustrate a sophisticated form of metacognitive control, in which learners qualitatively shift encoding strategies to match the demands of anticipated tests.

  15. submitter Test strategies for industrial testers for converter controls equipment

    CERN Document Server

    Oleniuk, P; Kasampalis, V; Nisbet, D; Todd, B; Uznański, S

    2017-01-01

    Power converters and their controls electronics are key elements for the operation of the CERN accelerator complex, having a direct impact on its availability. To prevent early-life failures and provide means to verify electronics, a set of industrial testers is used throughout the converters controls electronics' life cycle. The roles of the testers are to validate mass production during the manufacturing phase and to provide means to diagnose and repair failed modules that are brought back from operation. In the converter controls electronics section of the power converters group in the technology department of CERN (TE/EPC/CCE), two main test platforms have been adopted: a PXI platform for mixed analogue-digital functional tests and a JTAG Boundary-Scan platform for digital interconnection and functional tests. Depending on the functionality of the device under test, the appropriate test platforms are chosen. This paper is a follow-up to results presented at the TWEPP 2015 conference, adding the boundary s...

  16. Cross-View of Testing Techniques Toward Improving Web-Based Application Testing

    Directory of Open Access Journals (Sweden)

    Mostafa Kandil

    2012-03-01

    Full Text Available Web Applications (WAs failures may lead to collapse of the institutions, therefore the importance of good quality WAs is increasing over the time. Testing is one of the best quality metrics that decide whether WAs are reliable or not. WAs testing approaches suffer from the lack of proper coverage of WAs functional requirements testing. On the other hand some approaches produce test cases that already cover WAs testing but they also produce a great number of irrelevant test cases. This research analyzed the main testing approaches for WAs and GUI applications. Also we have an overview of Test-Driven Development and its effects on the current development. The specification of good testing approach that satisfies the proper testing is then presented.

  17. Standing of nucleic acid testing strategies in veterinary diagnosis laboratories to uncover Mycobacterium tuberculosis complex members

    Directory of Open Access Journals (Sweden)

    Pedro eCosta

    2014-10-01

    Full Text Available Nucleic acid testing (NAT designate any molecular approach used for the detection, identification and characterization of pathogenic microorganisms, enabling the rapid, specific and sensitive diagnostic of infectious diseases, such as tuberculosis. These assays have been widely used since the 90´s of the last century in human clinical laboratories and, subsequently, also in veterinary diagnostics. Most NAT strategies are based in the polymerase chain reaction (PCR and its several enhancements and variations. From the conventional PCR, real-time PCR and its combinations, isothermal DNA amplification, to the nanotechnologies, here we review how the NAT assays have been applied to decipher if and which member of the Mycobacterium tuberculosis complex is present in a clinical sample. Recent advances in DNA sequencing also brought new challenges and have made possible to generate rapidly and at a low cost, large amounts of sequence data. This revolution with the high-throughput sequencing (HTS technologies makes whole genome sequencing (WGS and metagenomics the trendiest NAT strategies, today. The ranking of NAT techniques in the field of clinical diagnostics is rising, and we provide a SWOT (Strengths, Weaknesses, Opportunities and Threats analysis with our view of the use of molecular diagnosis for detecting tuberculosis in veterinary laboratories, notwithstanding the gold standard being still the classical culture of the agent. The complementary use of both classical and molecular diagnosis approaches is recommended to speed the diagnostic, enabling a fast decision by competent authorities and rapid tackling of the disease.

  18. Standing of nucleic acid testing strategies in veterinary diagnosis laboratories to uncover Mycobacterium tuberculosis complex members.

    Science.gov (United States)

    Costa, Pedro; Botelho, Ana; Couto, Isabel; Viveiros, Miguel; Inácio, João

    2014-01-01

    Nucleic acid testing (NAT) designate any molecular approach used for the detection, identification, and characterization of pathogenic microorganisms, enabling the rapid, specific, and sensitive diagnostic of infectious diseases, such as tuberculosis. These assays have been widely used since the 90s of the last century in human clinical laboratories and, subsequently, also in veterinary diagnostics. Most NAT strategies are based in the polymerase chain reaction (PCR) and its several enhancements and variations. From the conventional PCR, real-time PCR and its combinations, isothermal DNA amplification, to the nanotechnologies, here we review how the NAT assays have been applied to decipher if and which member of the Mycobacterium tuberculosis complex is present in a clinical sample. Recent advances in DNA sequencing also brought new challenges and have made possible to generate rapidly and at a low cost, large amounts of sequence data. This revolution with the high-throughput sequencing (HTS) technologies makes whole genome sequencing (WGS) and metagenomics the trendiest NAT strategies, today. The ranking of NAT techniques in the field of clinical diagnostics is rising, and we provide a SWOT (Strengths, Weaknesses, Opportunities, and Threats) analysis with our view of the use of molecular diagnostics for detecting tuberculosis in veterinary laboratories, notwithstanding the gold standard being still the classical culture of the agent. The complementary use of both classical and molecular diagnostics approaches is recommended to speed the diagnostic, enabling a fast decision by competent authorities and rapid tackling of the disease.

  19. Reliability and normative values of the foot line test: a technique to assess foot posture

    DEFF Research Database (Denmark)

    Brushøj, C; Larsen, Klaus; Nielsen, MB;

    2007-01-01

    STUDY DESIGN: Test-retest reliability. OBJECTIVE: To examine the reliability and report normative values of a novel test, the foot line test (FLT), to describe foot morphology. BACKGROUND: Numerous foot examinations are performed each day, but most existing examination techniques have considerable......). There was no significant association between foot size and FLT values. CONCLUSION: The FLT is a reproducible technique to assess foot posture....

  20. Strategies and techniques to enhance constructed wetland performance for sustainable wastewater treatment.

    Science.gov (United States)

    Wu, Haiming; Fan, Jinlin; Zhang, Jian; Ngo, Huu Hao; Guo, Wenshan; Liang, Shuang; Hu, Zhen; Liu, Hai

    2015-10-01

    Constructed wetlands (CWs) have been used as an alternative to conventional technologies for wastewater treatment for more than five decades. Recently, the use of various modified CWs to improve treatment performance has also been reported in the literature. However, the available knowledge on various CW technologies considering the intensified and reliable removal of pollutants is still limited. Hence, this paper aims to provide an overview of the current development of CW strategies and techniques for enhanced wastewater treatment. Basic information on configurations and characteristics of different innovations was summarized. Then, overall treatment performance of those systems and their shortcomings were further discussed. Lastly, future perspectives were also identified for specialists to design more effective and sustainable CWs. This information is used to inspire some novel intensifying methodologies, and benefit the successful applications of potential CW technologies.

  1. Impulsivity and Speed-Accuracy Strategies in Intelligence Test Performance.

    Science.gov (United States)

    Phillips, Louise H.; Rabbitt, Patrick M. A.

    1995-01-01

    Whether relations between intelligence test performance and information processing measures depend on individual differences in speed-accuracy preferences rather than capacity limitations and whether the impact of strategic variables changes with increasing age or extraversion was studied with 83 adults ages 50 to 79 years. Results are discussed…

  2. Alternative testing strategies for predicting developmental toxicity of antifungal compound

    NARCIS (Netherlands)

    Li, H.

    2016-01-01

    Determination of safe human exposure levels of chemicals in toxicological risk assessments largely relies on animal toxicity data. In these toxicity studies, the highest number of animals are used for reproductive and developmental toxicity testing. Because of economic and ethical reasons, there is

  3. Pilot Test of an Innovative Interprofessional Education Assessment Strategy

    Science.gov (United States)

    Emmert, Michelle Christine

    2011-01-01

    The primary goal of this study was to test an innovative way of assessing students' teamwork skills in a controlled environment. Twenty-four second year students from Western University of Health Sciences (WesternU) participated in the experimental group and 22 third year students from WesternU participated in the control group. Students in the…

  4. The Adequacy of Environmental Education Techniques and Strategies Employed in Uluguru Mountains Hotspot

    Directory of Open Access Journals (Sweden)

    Joseph Manase

    2016-10-01

    Full Text Available Various studies about the environment consider different factors as sources of environmental deterioration. Such studies have not paid much attention on education as the remedy for environmental sustainability. Other studies have rarely considered environmental education approaches as the reason for lack of success in environmental education arrangements. This research had a focus on the adequacy of environmental education approaches, techniques and strategies employed in Uluguru Mountains in Morogoro. Social constructivist theory by Vigortsky (1958 was employed while case study research design and qualitative approach were deemed important for this research. Data collection was done by using interview and Focus Group Discussion methods. Objectives of the research were to: investigate adequacy of Environmental Education content, methods, awareness as well as the use of indigenous environmental knowledge. The findings show that, environmental education methods implemented in Uluguru Mountains are not satisfactory enough to improve environmental conditions. Again, indigenous knowledge has been less integrated into Environmental Education. Different environmental education methods need to be improved and integrated to create sustainable learning outcomes within Environmental Education. Keywords: Adequacy, Environmental Education, Approaches, Strategies, hotspot

  5. Regression Test-Selection Technique Using Component Model Based Modification: Code to Test Traceability

    Directory of Open Access Journals (Sweden)

    Ahmad A. Saifan

    2016-04-01

    Full Text Available Regression testing is a safeguarding procedure to validate and verify adapted software, and guarantee that no errors have emerged. However, regression testing is very costly when testers need to re-execute all the test cases against the modified software. This paper proposes a new approach in regression test selection domain. The approach is based on meta-models (test models and structured models to decrease the number of test cases to be used in the regression testing process. The approach has been evaluated using three Java applications. To measure the effectiveness of the proposed approach, we compare the results using the re-test to all approaches. The results have shown that our approach reduces the size of test suite without negative impact on the effectiveness of the fault detection.

  6. Second Language Reading Topic Familiarity and Test Score: Test-Taking Strategies for Multiple-Choice Comprehension Questions

    Science.gov (United States)

    Lee, Jia-Ying

    2011-01-01

    The main purpose of this study was to compare the strategies used by Chinese-speaking students when confronted with familiar versus unfamiliar topics in a multiple-choice format reading comprehension test. The focus was on describing what students do when they are taking reading comprehension tests by asking students to verbalize their thoughts.…

  7. Uniparental disomy in Robertsonian translocations: strategies for uniparental disomy testing.

    Science.gov (United States)

    Yip, Moh-Ying

    2014-04-01

    Robertsonian translocations (ROBs) are whole arm rearrangements involving the acrocentric chromosomes 13-15 and 21-22 and carriers are at increased risk for aneuploidy and thus uniparental disomy (UPD). Chromosomes 14 and 15 are imprinted with expression of genes dependent on the parental origin of the chromosome. Correction of a trisomic or monosomic conceptus for chromosomes 14 or 15 would lead to one of the established UPD 14mat/pat or UPD 15 (Prader-Willi/Angelman) syndromes (PWS/AS). In view of this, prenatal UPD testing should be considered for balanced carriers of a ROB, fetuses with a familial or de novo balanced ROB that contains chromosome 14 or 15 or with a normal karyotype when a parent is a carrier of a balanced ROB with a 14 or 15. Individuals with congenital anomalies and an abnormal phenotype and carry a ROB involving the two imprinted chromosomes should also be UPD tested.

  8. Cross-Cloud Testing Strategies Over Cloud Computing

    Directory of Open Access Journals (Sweden)

    Mr. Nageswararao,

    2014-06-01

    Full Text Available Cloud computing is the new paradigm to deliver all the hosted services over internet on demand. The ultimate goal of cloud computing paradigm is to realize computing as a utility. The cloud is rapidly maturing towards its goal to support a wide variety of enterprise and consumer services and real-world applications. Recently a movement towards cross cloud also called as multi-clouds or inters clouds or cloud-of-clouds has emerged which take advantage of multiple independent cloud provider offers for cloud resilience and dependability. This cross cloud represents the next logical wave in computing, enabling complex hybrid applications, cost and performance optimization, enhanced reliability, customer flexibility and lock-in avoidance. Providing testing as a service (TaaS in cross clouds become hot topics in industry. Testing heterogeneous e-commerce sites, Software as a Service solutions, and Cloud based applications is extremely challenging.

  9. Novel Preclinical Testing Strategies for Treatment of Metastatic Pheochromocytoma

    Science.gov (United States)

    2014-09-01

    21285984; PubMed Central PMCID: PMC3049604. 3. Lin G, Hill DK, Andrejeva G, Boult JK, Troy H, Fong AC, et al. Dichloroacetate induces autophagy in...testing. Author Contributions Conceived and designed the experiments: JFP AST GGS. Performed the experiments: JFP PGK SF AG. Analyzed the data: JFP PGK...GGS AST. Contributed reagents/materials/analysis tools: SF AG KP GGS. Wrote the paper: JFP AST KP GGS. References 1. DeLellis RA, Lloyd RV, Heitz PU

  10. Effect of irrigation techniques and strategies on water footprint of growing crops

    Science.gov (United States)

    Chukalla, A. D.; Krol, M. S.; Hoekstra, A. Y. Y.

    2014-12-01

    technique. This rank though changes in non-moisture limiting condition (wet year) drip performing better in reducing the WF of growing crops than sub-surface drip. It was observed that with all range of irrigation techniques, strategies and field management practices there is more room in reducing the WF of growing crops in loam than sandy-loam soil.

  11. AOF LTAO mode: reconstruction strategy and first test results

    Science.gov (United States)

    Oberti, Sylvain; Kolb, Johann; Le Louarn, Miska; La Penna, Paolo; Madec, Pierre-Yves; Neichel, Benoit; Sauvage, Jean-François; Fusco, Thierry; Donaldson, Robert; Soenke, Christian; Suárez Valles, Marcos; Arsenault, Robin

    2016-07-01

    GALACSI is the Adaptive Optics (AO) system serving the instrument MUSE in the framework of the Adaptive Optics Facility (AOF) project. Its Narrow Field Mode (NFM) is a Laser Tomography AO (LTAO) mode delivering high resolution in the visible across a small Field of View (FoV) of 7.5" diameter around the optical axis. From a reconstruction standpoint, GALACSI NFM intends to optimize the correction on axis by estimating the turbulence in volume via a tomographic process, then projecting the turbulence profile onto one single Deformable Mirror (DM) located in the pupil, close to the ground. In this paper, the laser tomographic reconstruction process is described. Several methods (virtual DM, virtual layer projection) are studied, under the constraint of a single matrix vector multiplication. The pseudo-synthetic interaction matrix model and the LTAO reconstructor design are analysed. Moreover, the reconstruction parameter space is explored, in particular the regularization terms. Furthermore, we present here the strategy to define the modal control basis and split the reconstruction between the Low Order (LO) loop and the High Order (HO) loop. Finally, closed loop performance obtained with a 3D turbulence generator will be analysed with respect to the most relevant system parameters to be tuned.

  12. Utilization of Emotional Freedom Techniques (EFT) to Reduce Test Anxiety in High Stakes Testing

    Science.gov (United States)

    Mohler, Marie Elaine

    2013-01-01

    There are many reasons a person may fail a high stakes test such as the National Council Licensure Examination for Registered Nurses (NCLEX-RN®). Sleep deprivation, illness, life stressors, knowledge deficit, and test anxiety are some of the common explanations. A student with test anxiety may feel threatened by this evaluation process. This…

  13. A novel technique for detecting antibiotic-resistant typhoid from rapid diagnostic tests.

    OpenAIRE

    2015-01-01

    Fluoroquinolone-resistant typhoid is increasing. An antigen-detecting rapid diagnostic test (RDT) can rapidly diagnose typhoid from blood cultures. A simple, inexpensive molecular technique performed with DNA from positive RDTs accurately identified gyrA mutations consistent with phenotypic susceptibility testing results. Field diagnosis combined with centralized molecular resistance testing could improve typhoid management and surveillance in low-resource settings.

  14. A Novel Technique for Detecting Antibiotic-Resistant Typhoid from Rapid Diagnostic Tests

    OpenAIRE

    2015-01-01

    Fluoroquinolone-resistant typhoid is increasing. An antigen-detecting rapid diagnotic test (RDT) can rapidly diagnose typhoid from blood cultures. A simple, inexpensive molecular technique performed with DNA from positive RDTs accurately identified gyrA mutations consistent with phenotypic susceptibility testing results. Field diagnosis combined with centralized molecular resistance testing could improve typhoid management and surveillance in low-resource settings.

  15. Managing the Testing Process Practical Tools and Techniques for Managing Hardware and Software Testing

    CERN Document Server

    Black, Rex

    2011-01-01

    New edition of one of the most influential books on managing software and hardware testing In this new edition of his top-selling book, Rex Black walks you through the steps necessary to manage rigorous testing programs of hardware and software. The preeminent expert in his field, Mr. Black draws upon years of experience as president of both the International and American Software Testing Qualifications boards to offer this extensive resource of all the standards, methods, and tools you'll need. The book covers core testing concepts and thoroughly examines the best test management practices

  16. Characteristics of test anxiety among medical students and congruence of strategies to address it

    Directory of Open Access Journals (Sweden)

    John Encandela

    2014-08-01

    Full Text Available Introduction: Medical students may experience test anxiety associated with ‘high stakes’ exams, such as Step 1 of the United States Medical Licensing Examination. Methods: We collected qualitative responses about test anxiety at three points in time from 93 second-year medical students engaged in studying for and taking Step 1. Results: Causes of test anxiety as reported by students were related to negative self-talk during preparation for the exam. Effects of anxiety had to do with emotional well-being, cognitive functioning, and physical well-being. Strategies included socializing with others and a variety of cognitive and physical approaches. Comparison of individuals’ strategies with causes and effects showed some congruence, but substantial incongruence between the types of strategies chosen and the reported causes and effects of test anxiety. Discussion: Students’ adoption of a ‘menu’ of strategies rather than one or two carefully selected strategies suggest inefficiencies that might be addressed by interventions, such as advisor-directed conversations with students and incorporating student self-assessment and strategies for managing anxiety within courses on test-taking. Such interventions are in need of further study. An annotated list of evidence-based strategies would be helpful to students and educators. Most important, test anxiety should be viewed by medical educators as a ‘real’ experience, and students would benefit from educator support.

  17. Validation through Understanding Test-Taking Strategies: An Illustration With the CELPIP-General Reading Pilot Test Using Structural Equation Modeling

    Science.gov (United States)

    Wu, Amery D.; Stone, Jake E.

    2016-01-01

    This article explores an approach for test score validation that examines test takers' strategies for taking a reading comprehension test. The authors formulated three working hypotheses about score validity pertaining to three types of test-taking strategy (comprehending meaning, test management, and test-wiseness). These hypotheses were…

  18. Time Truncated Testing Strategy using Multiple Testers: Lognormal Distributed Lifetime

    Directory of Open Access Journals (Sweden)

    Itrat Batool Naqvi

    2014-06-01

    Full Text Available In this study, group acceptance sampling plan proposed by Aslam et al. (2011 is reconsidered when the lifetime variant of the test item follows lognormal distribution. The optimal plan parameters are obtained by considering various pre-specified parameters. The plan parameters are obtained using the non-linear optimization solution using two points approach. The advantage of the proposed plan is discussed over the existing plan using the single point approach and the proposed plan is more efficient than the existing plan.

  19. TRAINING STRATEGIES FOR LISTENING SUB-TEST IN IELTS

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The listening sub-test in IELTS is divided into four sections:section one and two test candidates’survival skills in the U.K.;section three and four,candidates’study skills,Ih trainingpractice,the instructor may divide the listening material intotwo parts.In the first part—survival English,culturalbackground knowledge of daily life in the U.K.should be takenas the training focus.Dialogues concerning a new arrival’s dailyactivities in the U.K.may be chosen as listening material.Thesecond part,Academic English training is the most challengingtask.To understand a university lecture or academic interview,a good command of academic vocabulary is essential,so theinstructor should design some exercises to help students memorizeacademic vocabulary.The training focus for the academicEnglish part is the skill of grasping the main points of a lecture orinterview.Students should show how to write outlines andsummaries.Gap-fill and T&F&N forms may be adopted forsummary and outline training.

  20. TOXICITY TESTING IN THE 21ST CENTURY: A VISION AND A STRATEGY

    DEFF Research Database (Denmark)

    Krewski, D.; Acosta, D.; Andersen, M.

    2010-01-01

    With the release of the landmark report Toxicity Testing in the 21st Century: A Vision and a Strategy, the U. S. National Academy of Sciences, in 2007, precipitated a major change in the way toxicity testing is conducted. It envisions increased efficiency in toxicity testing and decreased animal ...

  1. Test Takers' Performance Appraisals, Appraisal Calibration, and Cognitive and Metacognitive Strategy Use

    Science.gov (United States)

    Phakiti, Aek

    2016-01-01

    The current study explores the nature and relationships among test takers' performance appraisals, appraisal calibration, and reported cognitive and metacognitive strategy use in a language test situation. Performance appraisals are executive processes of strategic competence for judging test performance (e.g., evaluating the correctness or…

  2. College Students' Study Strategies as a Function of Testing: An Investigation into Metacognitive Self-Regulation

    Science.gov (United States)

    Ross, Margaret E.; Green, Samuel B.; Salisbury-Glennon, Jill D.; Tollefson, Nona

    2006-01-01

    We conducted the present study to investigate whether college students adjust their study strategies to meet the cognitive demands of testing, a metacognitive self-regulatory skill. Participants were randomly assigned to one of the two testing conditions. In one condition we told participants to study for a test that required deep-level cognitive…

  3. Transient excitation and data processing techniques employing the fast fourier transform for aeroelastic testing

    Science.gov (United States)

    Jennings, W. P.; Olsen, N. L.; Walter, M. J.

    1976-01-01

    The development of testing techniques useful in airplane ground resonance testing, wind tunnel aeroelastic model testing, and airplane flight flutter testing is presented. Included is the consideration of impulsive excitation, steady-state sinusoidal excitation, and random and pseudorandom excitation. Reasons for the selection of fast sine sweeps for transient excitation are given. The use of the fast fourier transform dynamic analyzer (HP-5451B) is presented, together with a curve fitting data process in the Laplace domain to experimentally evaluate values of generalized mass, model frequencies, dampings, and mode shapes. The effects of poor signal to noise ratios due to turbulence creating data variance are discussed. Data manipulation techniques used to overcome variance problems are also included. The experience is described that was gained by using these techniques since the early stages of the SST program. Data measured during 747 flight flutter tests, and SST, YC-14, and 727 empennage flutter model tests are included.

  4. Development of Probabilistic Life Prediction Methodologies and Testing Strategies for MEMS

    Science.gov (United States)

    Jadaan, Osama M.

    2003-01-01

    This effort is to investigate probabilistic life prediction methodologies for MicroElectroMechanical Systems (MEMS) and to analyze designs that determine stochastic properties of MEMS. This includes completion of a literature survey regarding Weibull size effect in MEMS and strength testing techniques. Also of interest is the design of a proper test for the Weibull size effect in tensile specimens. The Weibull size effect is a consequence of a stochastic strength response predicted from the Weibull distribution. Confirming that MEMS strength is controlled by the Weibull distribution will enable the development of a probabilistic design methodology for MEMS - similar to the GRC developed CARES/Life program for bulk ceramics. Another potential item of interest is analysis and modeling of material interfaces for strength as well as developing a strategy to handle stress singularities at sharp corners, filets, and material interfaces. The ultimate objective of this effort is to further develop and verify the ability of the Ceramics Analysis and Reliability Evaluation of Structuredlife (CARES/Life) code to predict the time-dependent reliability of MEMS structures subjected to multiple transient loads. Along these lines work may also be performed on transient fatigue life prediction methodologies.

  5. SOIL DESICCATION TECHNIQUES STRATEGIES FOR IMMOBILIZATION OF DEEP VADOSE CONTAMINANTS AT THE HANFORD CENTRAL PLATEAU

    Energy Technology Data Exchange (ETDEWEB)

    BENECKE MW; CHRONISTER GB; TRUEX MJ

    2012-01-30

    Deep vadose zone contamination poses some of the most difficult remediation challenges for the protection of groundwater at the Hanford Site where processes and technologies are being developed and tested for use in the on-going effort to remediate mobile contamination in the deep vadose zone, the area deep beneath the surface. Historically, contaminants were discharged to the soil along with significant amounts of water, which continues to drive contaminants deeper in the vadose zone toward groundwater. Soil desiccation is a potential in situ remedial technology well suited for the arid conditions and the thick vadose zone at the Hanford Site. Desiccation techniques could reduce the advance of contaminants by removing the pore water to slow the rate of contaminants movement toward groundwater. Desiccation technologies have the potential to halt or slow the advance of contaminants in unsaturated systems, as well as aid in reduction of contaminants from these same areas. Besides reducing the water flux, desiccation also establishes capillary breaks that would require extensive rewetting to resume pore water transport. More importantly, these techniques have widespread application, whether the need is to isolate radio nuclides or address chemical contaminant issues. Three different desiccation techniques are currently being studied at Hanford.

  6. Automated Software Testing Using Metahurestic Technique Based on An Ant Colony Optimization

    CERN Document Server

    Srivastava, Praveen Ranjan

    2011-01-01

    Software testing is an important and valuable part of the software development life cycle. Due to time, cost and other circumstances, exhaustive testing is not feasible that's why there is a need to automate the software testing process. Testing effectiveness can be achieved by the State Transition Testing (STT) which is commonly used in real time, embedded and web-based type of software systems. Aim of the current paper is to present an algorithm by applying an ant colony optimization technique, for generation of optimal and minimal test sequences for behavior specification of software. Present paper approach generates test sequence in order to obtain the complete software coverage. This paper also discusses the comparison between two metaheuristic techniques (Genetic Algorithm and Ant Colony optimization) for transition based testing

  7. Measurement techniques and instruments suitable for life-prediction testing of photovoltaic arrays. Interim report

    Energy Technology Data Exchange (ETDEWEB)

    Noel, G.T.; Sliemers, F.A.; Deringer, G.C.; Wood, V.E.; Wilkes, K.E.; Gaines, G.B.; Carmichael, D.C.

    1978-01-15

    The validation of a service life of 20 years for low-cost photovoltaic arrays must be accomplished through accelerated life-prediction tests. A methodology for such tests has been developed in a preceding study. The results discussed consist of the initial identification and assessment of all known measurement techniques and instruments that might be used in these life-prediction tests. Array failure modes, relevant materials property changes, and primary degradation mechanisms are discussed as a prerequisite to identifying suitable measurement techniques and instruments. Candidate techniques and instruments are identified on the basis of extensive reviews of published and unpublished information. These methods are organized in six measurement categories--chemical, electrical, optical, thermal, mechanical, and ''other physicals''. Using specified evaluation criteria, the most promising techniques and instruments for use in life-prediction tests of arrays are then selected. These recommended techniques and their characteristics are described. Recommendations are made regarding establishment of the adequacy, particularly with respect to precision, of the more fully developed techniques for this application, and regarding the experimental evaluation of promising developmental techniques. Measurement needs not satisfied by presently available techniques/instruments are also identified.

  8. Reproductive strategies of Aedes albopictus (Diptera: Culicidae) and implications for the sterile insect technique.

    Science.gov (United States)

    Oliva, Clelia F; Damiens, David; Vreysen, Marc J B; Lemperière, Guy; Gilles, Jérémie

    2013-01-01

    Male insects are expected to optimize their reproductive strategy according to the availability of sperm or other ejaculatory materials, and to the availability and reproductive status of females. Here, we investigated the reproductive strategy and sperm management of male and virgin female Aedes albopictus, a mosquito vector of chikungunya and dengue viruses. The dynamics of semen transfer to the female bursa inseminalis and spermathecae were observed. Double-mating experiments were conducted to study the effect of time lapsed or an oviposition event between two copulations on the likelihood of a female double-insemination and the use of sperm for egg fertilization; untreated fertile males and radio-sterilised males were used for this purpose. Multiple inseminations and therefore the possibility of sperm competition were limited to matings closely spaced in time. When two males consecutively mated the same female within a 40 min interval, in ca. 15% of the cases did both males sire progeny. When the intervals between the copulations were longer, all progeny over several gonotrophic cycles were offspring of the first male. The mating behavior of males was examined during a rapid sequence of copulations. Male Ae. albopictus were parceling sperm allocation over several matings; however they would also attempt to copulate with females irrespective of the available sperm supply or accessory gland secretion material. During each mating, they transferred large quantities of sperm that was not stored for egg fertilization, and they attempted to copulate with mated females with a low probability of transferring their genes to the next generation. The outcomes of this study provided in addition some essential insights with respect to the sterile insect technique (SIT) as a vector control method.

  9. Comprehensive In Vitro Toxicity Testing of a Panel of Representative Oxide Nanomaterials: First Steps towards an Intelligent Testing Strategy

    Science.gov (United States)

    Farcal, Lucian; Torres Andón, Fernando; Di Cristo, Luisana; Rotoli, Bianca Maria; Bussolati, Ovidio; Bergamaschi, Enrico; Mech, Agnieszka; Hartmann, Nanna B.; Rasmussen, Kirsten; Riego-Sintes, Juan; Ponti, Jessica; Kinsner-Ovaskainen, Agnieszka; Rossi, François; Oomen, Agnes; Bos, Peter; Chen, Rui; Bai, Ru; Chen, Chunying; Rocks, Louise; Fulton, Norma; Ross, Bryony; Hutchison, Gary; Tran, Lang; Mues, Sarah; Ossig, Rainer; Schnekenburger, Jürgen; Campagnolo, Luisa; Vecchione, Lucia; Pietroiusti, Antonio; Fadeel, Bengt

    2015-01-01

    Nanomaterials (NMs) display many unique and useful physico-chemical properties. However, reliable approaches are needed for risk assessment of NMs. The present study was performed in the FP7-MARINA project, with the objective to identify and evaluate in vitro test methods for toxicity assessment in order to facilitate the development of an intelligent testing strategy (ITS). Six representative oxide NMs provided by the EC-JRC Nanomaterials Repository were tested in nine laboratories. The in vitro toxicity of NMs was evaluated in 12 cellular models representing 6 different target organs/systems (immune system, respiratory system, gastrointestinal system, reproductive organs, kidney and embryonic tissues). The toxicity assessment was conducted using 10 different assays for cytotoxicity, embryotoxicity, epithelial integrity, cytokine secretion and oxidative stress. Thorough physico-chemical characterization was performed for all tested NMs. Commercially relevant NMs with different physico-chemical properties were selected: two TiO2 NMs with different surface chemistry – hydrophilic (NM-103) and hydrophobic (NM-104), two forms of ZnO – uncoated (NM-110) and coated with triethoxycapryl silane (NM-111) and two SiO2 NMs produced by two different manufacturing techniques – precipitated (NM-200) and pyrogenic (NM-203). Cell specific toxicity effects of all NMs were observed; macrophages were the most sensitive cell type after short-term exposures (24-72h) (ZnO>SiO2>TiO2). Longer term exposure (7 to 21 days) significantly affected the cell barrier integrity in the presence of ZnO, but not TiO2 and SiO2, while the embryonic stem cell test (EST) classified the TiO2 NMs as potentially ‘weak-embryotoxic’ and ZnO and SiO2 NMs as ‘non-embryotoxic’. A hazard ranking could be established for the representative NMs tested (ZnO NM-110 > ZnO NM-111 > SiO2 NM-203 > SiO2 NM-200 > TiO2 NM-104 > TiO2 NM-103). This ranking was different in the case of embryonic tissues, for

  10. BENEFITS OF AN APPLICATION OF EVOLUTIONARY STRATEGY IN THE PROCESS OF TEST DATA GENERATION

    Directory of Open Access Journals (Sweden)

    Marek ŻUKOWICZ

    2016-04-01

    Full Text Available The aim of the article is to highlight the advantages that can be obtained through the use of evolutionary strategy in software testing, specifically in the process of test data generation. The first chapter introduces the reader to the topic of the article. Presents information of the problem of software quality, test data fitness and quality criteria. The second chapter provides an overview of the publication in which is described the test data generation problem by using evolu-tionary strategies. In this chapter there are presented, different approaches to address the optimization problem of test data selection. The third chapter sets out the advantages which in the opinion of the author result from the application of evolutionary strategy in the process of test data generation. In this section have been drawn conclusions from the article, from books listed in the bibliography. The author of the article presents advantages of evolutionary strategy too as a person, which tests a software in practise. The last chapter in addition to summaries and conclusions, proposes the author to suggest in which issues related to testing could be used evolutionary strategies.

  11. Alternative Testing Strategies for Nanomaterials: State of the Science and Considerations for Risk Analysis.

    Science.gov (United States)

    Shatkin, J A; Ong, K J

    2016-08-01

    The rapid growth of the nanotechnology industry has warranted equal progress in the nanotoxicology and risk assessment fields. In vivo models have traditionally been used to determine human and environmental risk for chemicals; however, the use of these tests has limitations, and there are global appeals to develop reliable alternatives to animal testing. Many have investigated the use of alternative (nonanimal) testing methods and strategies have quickly developed and resulted in the generation of large toxicological data sets for numerous nanomaterials (NMs). Due to the novel physicochemical properties of NMs that are related to surface characteristics, the approach toward toxicity test development has distinct considerations from traditional chemicals, bringing new requirements for adapting these approaches for NMs. The methodical development of strategies that combine multiple alternative tests can be useful for predictive NM risk assessment and help screening-level decision making. This article provides an overview of the main developments in alternative methods and strategies for reducing uncertainty in NM risk assessment, including advantages and disadvantages of in vitro, ex vivo, and in silico methods, and examples of existing comprehensive strategies. In addition, knowledge gaps are identified toward improvements for experimental and strategy design, specifically highlighting the need to represent realistic exposure scenarios and to consider NM-specific concerns such as characterization, assay interferences, and standardization. Overall, this article aims to improve the reliability and utility of alternative testing methods and strategies for risk assessment of manufactured NMs.

  12. Challenges, Strategies and Techniques for International Training in Technology for Cultural Heritage Conservation

    Science.gov (United States)

    Eppich, R.; Almagro Vidal, A.

    2013-07-01

    , Jordan, Argentina, United Arab Emirates, United States of America and around 20 other countries. These strategies deal with establishing methodologies and guiding principles for the selection of technologies, highlighting successful illustrated examples, levelling uneven educational bases and gaining access to expertise. The authors have developed these strategies and techniques to appeal, engage and succeed with such diverse groups - to encourage the participants to cooperate on a common goal and overcome specific challenges while embracing the technology and thinking critically about its appropriate application for the conservation of cultural heritage in their home countries. Other strategies include setting norms that respect the various cultures and differing levels of technology education, offering voluntary sessions for more advanced and ambitious participants, finding and then adopting natural leaders as co-instructors and offering a mix of sessions including standard lectures combined with field and laboratory exercises and distance learning. This methodology and strategies have proven to be successful as the participants have provided positive evaluations months and/or years after the courses, implemented their own courses using the materials and methods and have established a strong, sustainable network related to this topic.

  13. The effect of alternative testing strategies and bio-exclusion practices on Johne's disease risk in test-negative herds.

    Science.gov (United States)

    More, S J; Sergeant, E S G; Strain, S; Cashman, W; Kenny, Kevin; Graham, D

    2013-03-01

    Herd classification is a key component of national Johne's disease (JD) control programs. Herds are categorized on the basis of test results, and separate sub-programs are followed for test-positive and test-negative herds. However, a test-negative herd result does not necessarily equate to JD freedom for reasons relating to disease pathogenesis and available diagnostic tests. Thus, in several countries, JD control programs define test-negative herds as having a "low risk" of infection below a specified prevalence. However, the approach is qualitative, and little quantitative work is available on herd-level estimates of probability of freedom in test-negative herds. This paper examines the effect over time of alternative testing strategies and bio-exclusion practices on JD risk in test-negative herds. A simulation model was developed in the programming language R. Key model inputs included sensitivity and specificity estimates for 3 individual animal diagnostic tests (serum ELISA, milk ELISA, and fecal culture), design prevalence, testing options, and testing costs. Key model outputs included the probability that infection will be detected if present at the design prevalence or greater (herd sensitivity; SeH), the probability that infection in the herd is either absent or at very low prevalence (i.e., less than the design prevalence; ProbF), the probability of an uninfected herd producing a false-positive result [P(False+)], and mean testing cost (HerdCost) for different testing strategies. The output ProbF can be updated periodically, incorporating data from additional herd testing and information on cattle purchases, and could form the basis for an output-based approach to herd classification. A high ProbF is very difficult to achieve, reflecting the low sensitivity of the evaluated tests. Moreover, ProbF is greatly affected by any risk of introduction of infection, decreasing in herds with poor bio-exclusion practices despite ongoing negative test results. The

  14. Effectiveness comparison of partially executed t-way test suite based generated by existing strategies

    Science.gov (United States)

    Othman, Rozmie R.; Ahmad, Mohd Zamri Zahir; Ali, Mohd Shaiful Aziz Rashid; Zakaria, Hasneeza Liza; Rahman, Md. Mostafijur

    2015-05-01

    Consuming 40 to 50 percent of software development cost, software testing is one of the most resource consuming activities in software development lifecycle. To ensure an acceptable level of quality and reliability of a typical software product, it is desirable to test every possible combination of input data under various configurations. Due to combinatorial explosion problem, considering all exhaustive testing is practically impossible. Resource constraints, costing factors as well as strict time-to-market deadlines are amongst the main factors that inhibit such consideration. Earlier work suggests that sampling strategy (i.e. based on t-way parameter interaction or called as t-way testing) can be effective to reduce number of test cases without effecting the fault detection capability. However, for a very large system, even t-way strategy will produce a large test suite that need to be executed. In the end, only part of the planned test suite can be executed in order to meet the aforementioned constraints. Here, there is a need for test engineers to measure the effectiveness of partially executed test suite in order for them to assess the risk they have to take. Motivated by the abovementioned problem, this paper presents the effectiveness comparison of partially executed t-way test suite generated by existing strategies using tuples coverage method. Here, test engineers can predict the effectiveness of the testing process if only part of the original test cases is executed.

  15. Qualitative research on point-of-care testing strategies and programs for HIV.

    Science.gov (United States)

    Engel, Nora; Pant Pai, Nitika

    2015-01-01

    Point-of-care (POC) testing in communities, home settings and primary healthcare centers plays an important role in cutting delays in HIV diagnosis and in the uptake of voluntary testing and counseling. Qualitative research methods have important potential to overcome the current challenges in expanding HIV POC testing programs and strategies, by examining the diagnostic processes, complex inter-relationships and patterns involved in making POC diagnostics work in real-world settings. This article reviews existing qualitative studies on POC testing strategies and programs for HIV. Qualitative research on POC diagnostics around the uptake of POC tests, the actual diagnostic and testing processes involved, the influence of POC tests on clinical decision-making, communication of decisions and decisions exercised by patients are limited. Equally limited are studies that explore adaptation of POC programs to various socio-cultural contexts. More qualitative research is needed to inform test developers, funders and policymakers.

  16. A test technique for measuring lightning-induced voltages on aircraft electrical circuits

    Science.gov (United States)

    Walko, L. C.

    1974-01-01

    The development of a test technique used for the measurement of lightning-induced voltages in the electrical circuits of a complete aircraft is described. The resultant technique utilizes a portable device known as a transient analyzer capable of generating unidirectional current impulses similar to lightning current surges, but at a lower current level. A linear relationship between the magnitude of lightning current and the magnitude of induced voltage permitted the scaling up of measured induced values to full threat levels. The test technique was found to be practical when used on a complete aircraft.

  17. Strategies and techniques for multi-component drug design from medicinal herbs and traditional Chinese medicine.

    Science.gov (United States)

    Wang, Yi; Fan, Xiaohui; Qu, Haibin; Gao, Xiumei; Cheng, Yiyu

    2012-01-01

    Many common diseases like diabetes, cardiovascular disease, and cancer are caused or exacerbated by disparate physiological, pathological, environmental, and lifestyle factors. However, the chief aim of current drug discovery approaches is to search for single-entity drugs that interact with well-defined molecular targets (a single receptor or enzyme). The concept of multi-target drugs or multi-component therapy is gaining increased attention with the discovery that many diseases (like hypertension) are best treated by multi-drug or multi-target therapies. Traditional medicines, such as traditional Chinese medicine (TCM) and Indian Ayurveda, have been re-evaluated and are becoming important resources for the discovery of bioactive molecules with therapeutic effects and for designing multi-targets drugs. This article provides an overview of new strategies and techniques to design therapeutic regimes that comprise more than one active ingredient to produce synergistic effects by simultaneously interacting with multiple molecular targets. Advances in phytochemistry, high throughput screening, DNA sequencing, systems biology, and bioinformatics can reveal the chemical composition and molecular mechanisms of TCM and together provide a new template for the early stages of drug discovery. Meanwhile, clinical knowledge of TCM provides a promising framework for multi-component drug design. A renaissance of multi-component drug discovery inspired by traditional medicine is possible.

  18. A new strategy in drug design of Chinese medicine: theory, method and techniques.

    Science.gov (United States)

    Yang, Hong-Jun; Shen, Dan; Xu, Hai-Yu; Lu, Peng

    2012-11-01

    The research and development (R&D) process of Chinese medicine, with one notable feature, clinical application based, is significantly different from which of chemical and biological medicine, from laboratory research to clinics. Besides, compound prescription is another character. Therefore, according to different R&D theories between Chinese and Western medicine, we put forward a new strategy in drug design of Chinese medicine, which focuses on "combination-activity relationship (CAR)", taking prescription discovery, component identification and formula optimization as three key points to identify the drugs of high efficacy and low toxicity. The method of drug design of Chinese medicine includes: new prescription discovery based on clinical data and literature information, component identification based on computing and experimental research, as well as formula optimization based on system modeling. This paper puts forward the concept, research framework and techniques of drug design of Chinese medicine, which embodies the R&D model of Chinese medicine, hoping to support the drug design of Chinese medicine theoretically and technologically.

  19. The sequential aerosol technique: a major component in an integrated strategy of intervention against Riverine Tsetse in Ghana.

    Directory of Open Access Journals (Sweden)

    Yahaya Adam

    Full Text Available BACKGROUND: An integrated strategy of intervention against tsetse flies was implemented in the Upper West Region of Ghana (9.62°-11.00° N, 1.40°-2.76° W, covering an area of ≈18,000 km(2 within the framework of the Pan-African Tsetse and Trypanosomosis Eradication Campaign. Two species were targeted: Glossina tachinoides and Glossina palpalis gambiensis. METHODOLOGY/PRINCIPAL FINDINGS: The objectives were to test the potentiality of the sequential aerosol technique (SAT to eliminate riverine tsetse species in a challenging subsection (dense tree canopy and high tsetse densities of the total sprayed area (6,745 km(2 and the subsequent efficacy of an integrated strategy including ground spraying (≈100 km(2, insecticide treated targets (20,000 and insecticide treated cattle (45,000 in sustaining the results of tsetse suppression in the whole intervention area. The aerial application of low-dosage deltamethrin aerosols (0.33-0.35 g a.i/ha was conducted along the three main rivers using five custom designed fixed-wings Turbo thrush aircraft. The impact of SAT on tsetse densities was monitored using 30 biconical traps deployed from two weeks before until two weeks after the operations. Results of the SAT monitoring indicated an overall reduction rate of 98% (from a pre-intervention mean apparent density per trap per day (ADT of 16.7 to 0.3 at the end of the fourth and last cycle. One year after the SAT operations, a second survey using 200 biconical traps set in 20 sites during 3 weeks was conducted throughout the intervention area to measure the impact of the integrated control strategy. Both target species were still detected, albeit at very low densities (ADT of 0.27 inside sprayed blocks and 0.10 outside sprayed blocks. CONCLUSIONS/SIGNIFICANCE: The SAT operations failed to achieve elimination in the monitored section, but the subsequent integrated strategy maintained high levels of suppression throughout the intervention area, which will

  20. The Supermatrix Technique: A Simple Framework for Hypothesis Testing with Missing Data

    Science.gov (United States)

    Lang, Kyle M.; Little, Todd D.

    2014-01-01

    We present a new paradigm that allows simplified testing of multiparameter hypotheses in the presence of incomplete data. The proposed technique is a straight-forward procedure that combines the benefits of two powerful data analytic tools: multiple imputation and nested-model ?2 difference testing. A Monte Carlo simulation study was conducted to…

  1. Design techniques for developing a computerized instrumentation test plan. [for wind tunnel test data acquisition system

    Science.gov (United States)

    Burnett, S. Kay; Forsyth, Theodore J.; Maynard, Everett E.

    1987-01-01

    The development of a computerized instrumentation test plan (ITP) for the NASA/Ames Research Center National Full Scale Aerodynamics Complex (NFAC) is discussed. The objective of the ITP program was to aid the instrumentation engineer in documenting the configuration and calibration of data acquisition systems for a given test at any of four low speed wind tunnel facilities (Outdoor Aerodynamic Research Facility, 7 x 10, 40 x 80, and 80 x 120) at the NFAC. It is noted that automation of the ITP has decreased errors, engineering hours, and setup time while adding a higher level of consistency and traceability.

  2. To test or to treat? An analysis of influenza testing and antiviral treatment strategies using economic computer modeling.

    Directory of Open Access Journals (Sweden)

    Bruce Y Lee

    Full Text Available BACKGROUND: Due to the unpredictable burden of pandemic influenza, the best strategy to manage testing, such as rapid or polymerase chain reaction (PCR, and antiviral medications for patients who present with influenza-like illness (ILI is unknown. METHODOLOGY/PRINCIPAL FINDINGS: We developed a set of computer simulation models to evaluate the potential economic value of seven strategies under seasonal and pandemic influenza conditions: (1 using clinical judgment alone to guide antiviral use, (2 using PCR to determine whether to initiate antivirals, (3 using a rapid (point-of-care test to determine antiviral use, (4 using a combination of a point-of-care test and clinical judgment, (5 using clinical judgment and confirming the diagnosis with PCR testing, (6 treating all with antivirals, and (7 not treating anyone with antivirals. For healthy younger adults ( or = 65 years old, in both seasonal and pandemic influenza scenarios, employing PCR was the most cost-effective option, with the closest competitor being clinical judgment (when judgment accuracy > or = 50%. Point-of-care testing plus clinical judgment was cost-effective with higher probabilities of influenza. Treating all symptomatic ILI patients with antivirals was cost-effective only in older adults. CONCLUSIONS/SIGNIFICANCE: Our study delineated the conditions under which different testing and antiviral strategies may be cost-effective, showing the importance of accuracy, as seen with PCR or highly sensitive clinical judgment.

  3. A comparison of the presumptive luminol test for blood with four non-chemiluminescent forensic techniques.

    Science.gov (United States)

    Webb, Joanne L; Creamer, Jonathan I; Quickenden, Terence I

    2006-01-01

    Presumptive blood detection tests are used by forensic investigators to detect trace amounts of blood or to investigate suspicious stains. Through the years, a number of articles have been published on the popular techniques of the day. However, there is no single paper that critiques and compares the five most common presumptive blood detection tests currently in use: luminol, phenolphthalein (Kastle-Meyer), leucomalachite green, Hemastix and the forensic light source. The present authors aimed to compare the above techniques with regard to their sensitivity, ease of use and safety. The luminol test was determined to be the most sensitive of the techniques, while Hemastix is a suitable alternative when the luminol test is not appropriate.

  4. Testing a social psychological model of strategy use with students of english as a foreign language.

    Science.gov (United States)

    Hsiao, Tsung-Yuan

    2004-12-01

    This replication study tested MacIntyre's Social Psychological Model of Strategy Use. Participants were 137 first-year college students (100 men and 37 women), all in their late teens or early 20s, learning English as a foreign language in a university in Taiwan. McIntyre specified three conditions for use of language-learning strategies in his model: awareness of the strategy, having a reason to use it, and not having a reason not to use it. Stepwise multiple regression analyses of data measured by Oxford's 50-item Strategy Inventory for Language Learning partially support this model because only Knowledge about the Strategy (representing the first condition) and Difficulty about Using It (representing the third condition) made significant independent contributions to the prediction of use of most of the 50 strategies. Close examination of the results poses questions about MacIntyre and Noels' thesis, as implied in their revised model, that reason to use the strategy and reason not to use the strategy are independent. The present replication suggests a need for further revision of the model. Use of methods more advanced than the multiple regression is recommended to test and refine the model.

  5. An Investigation of the Effectiveness of Vocabulary Learning Strategies on Iranian EFL Learners' Vocabulary Test Score

    Science.gov (United States)

    Rahimy, Ramin; Shams, Kiana

    2012-01-01

    This study aims to investigate the effectiveness of vocabulary learning strategies on Iranian EFL learners' vocabulary test score. To achieve this aim, fifty Intermediate level students from Kish English Institute were randomly selected from among fifteen classes after administering the Oxford Placement Test (OPT). Then, an intermediate level…

  6. Test-and-Treat Strategies for Helicobacter pylori in Uninvestigated Dyspepsia: A Canadian Economic Anaylsis

    Directory of Open Access Journals (Sweden)

    John K Marshall

    2000-01-01

    Full Text Available BACKGROUND: Recognition of the pivotal role of Helicobacter pylori in the pathogenesis of peptic ulcer disease has revolutionized primary care approaches to dyspepsia. Decision analysis was used to compare the cost effectiveness of empirical ranitidine with a test and treat strategy using either H pylori serology or the 13carbon-urea breath test (13C-UBT.

  7. Strategies Underlying Psychometric Test Responses in Young and Middle-aged Adults of Varying Educational Background.

    Science.gov (United States)

    Macrae, Kristina S.

    The aim of this study was to investigate the strategies leading to test item responses in 60 young (20-25 years) and 60 middle-aged (35-40 years) adults, whose highest level of education had been either secondary, technical or university. Subjects were individually administered a 12 item test similar to Raven's Progressive Matrices, and were…

  8. The Effects of Using Selected Metacognitive Strategies on ACT Mathematics Sub-Test Scores

    Science.gov (United States)

    LeMay, Jeffrey W.

    2016-01-01

    This quasi-experimental post-test only control group designed quantitative study examined whether or not members of an experimental group of participants who utilized two metacognitive strategy training regimens experienced a significant increase in their ACT mathematics sub-test scores compared to a group of students who did not utilize either of…

  9. Strategies Underlying Psychometric Test Responses in Young and Middle-aged Adults of Varying Educational Background.

    Science.gov (United States)

    Macrae, Kristina S.

    The aim of this study was to investigate the strategies leading to test item responses in 60 young (20-25 years) and 60 middle-aged (35-40 years) adults, whose highest level of education had been either secondary, technical or university. Subjects were individually administered a 12 item test similar to Raven's Progressive Matrices, and were…

  10. Voices of University Students with ADHD about Test-Taking: Behaviors, Needs, and Strategies

    Science.gov (United States)

    Ofiesh, Nicole; Moniz, Erin; Bisagno, Joan

    2015-01-01

    In order to understand the test-taking behavior, needs, and strategies of postsecondary students with Attention Deficit Hyperactivity Disorder (ADHD), focus group comments from 17 university students with ADHD were analyzed. These comments formed the basis for a series of research studies that are in progress regarding test-taking and individuals…

  11. Do Attachment Style and Emotion Regulation Strategies Indicate Distress in Predictive Testing?

    NARCIS (Netherlands)

    L.B. van der Meer (Lucienne); M.A.J. van Duijn (Marijtje A. J.); E.J. Giltay (Erik); A. Tibben (Arend)

    2015-01-01

    textabstractPredictive genetic testing for a neurogenetic disorder evokes strong emotions, and may lead to distress. The aim of this study is to investigate whether attachment style and emotion regulation strategies are associated with distress in persons who present for predictive testing for a neu

  12. Strategy for applying scaling technique to water retention curves of forest soils

    Science.gov (United States)

    Hayashi, Y.; Kosugi, K.; Mizuyama, T.

    2009-12-01

    Describing the infiltration of water in soils on a forested hillslope requires the information of spatial variability of water retention curve (WRC). By using a scaling technique, Hayashi et al. (2009), found that the porosity mostly characterizes the spatial variability of the WRCs on a forested hillslope. This scaling technique was based on a model, which assumes a lognormal pore size distribution and contains three parameters: the median of log-transformed pore radius, ψm, the variance of log-transformed pore radius, σ, and the effective porosity, θe. Thus, in the scaling method proposed by Hayashi et al. (2009), θe is a scaling factor, which should be determined for each individual soil, and that ψm and σ are reference parameter common for the whole data set. They examined this scaling method using θe calculated as a difference between the observed saturated water content and water content observed at ψ = -1000 cm for each sample and, ψm and σ derived from the whole data set of WRCs on the slope. Then it was showed that this scaling method could explain almost 90 % of the spatial variability in WRCs on the forested hillslope. However, this method requires the whole data set of WRCs for deriving the reference parameters (ψm and σ). For applying the scaling technique more practically, in this study, we tested a scaling method using the reference parameter derived from the WRCs at a small part of the slope. In order to examine the proposed scaling method, the WRCs for the 246 undisturbed forest soil samples, collected at 15 points distributed from downslope to upslope segments, were observed. In the proposed scaling method, we optimized the common ψm and σ to the WRCs for six soil samples, collected at one point on the middle-slope, and applied these parameters to a reference parameter for the whole data sets. The scaling method proposed by this study exhibited an increase of only 6 % in the residual sum of squares as compared with that of the method

  13. Advanced spatio-temporal filtering techniques for photogrammetric image sequence analysis in civil engineering material testing

    Science.gov (United States)

    Liebold, F.; Maas, H.-G.

    2016-01-01

    The paper shows advanced spatial, temporal and spatio-temporal filtering techniques which may be used to reduce noise effects in photogrammetric image sequence analysis tasks and tools. As a practical example, the techniques are validated in a photogrammetric spatio-temporal crack detection and analysis tool applied in load tests in civil engineering material testing. The load test technique is based on monocular image sequences of a test object under varying load conditions. The first image of a sequence is defined as a reference image under zero load, wherein interest points are determined and connected in a triangular irregular network structure. For each epoch, these triangles are compared to the reference image triangles to search for deformations. The result of the feature point tracking and triangle comparison process is a spatio-temporally resolved strain value field, wherein cracks can be detected, located and measured via local discrepancies. The strains can be visualized as a color-coded map. In order to improve the measuring system and to reduce noise, the strain values of each triangle must be treated in a filtering process. The paper shows the results of various filter techniques in the spatial and in the temporal domain as well as spatio-temporal filtering techniques applied to these data. The best results were obtained by a bilateral filter in the spatial domain and by a spatio-temporal EOF (empirical orthogonal function) filtering technique.

  14. Leakage Current Optimization Techniques During Test Based on Don't Care Bits Assignment

    Institute of Scientific and Technical Information of China (English)

    Wei Wang; Yu Hu; Yin-He Han; Xiao-Wei Li; You-Sheng Zhang

    2007-01-01

    It is a well-known fact that test power consumption may exceed that during functional operation. Leakage power dissipation caused by leakage current in Complementary Metal-Oxide-Semiconductor (CMOS) circuits during test has become a significant part of the total power dissipation. Hence, it is important to reduce leakage power to prolong battery life in portable systems which employ periodic self-test, to increase test reliability and to reduce test cost. This paper analyzes leakage current and presents a kind of leakage current simulator based on the transistor stacking effect.Using it, we propose techniques based on don't care bits (denoted by Xs) in test vectors to optimize leakage current in integrated circuit (IC) test by genetic algorithm. The techniques identify a set of don't care inputs in given test vectors and reassign specified logic values to the X inputs by the genetic algorithm to get minimum leakage vector (MLV).Experimental results indicate that the techniques can effectually optimize leakage current of combinational circuits and sequential circuits during test while maintaining high fault coverage.

  15. Do Attachment Style and Emotion Regulation Strategies Indicate Distress in Predictive Testing?

    Science.gov (United States)

    van der Meer, Lucienne B; van Duijn, Erik; Giltay, Erik J; Tibben, Aad

    2015-10-01

    Predictive genetic testing for a neurogenetic disorder evokes strong emotions, and may lead to distress. The aim of this study is to investigate whether attachment style and emotion regulation strategies are associated with distress in persons who present for predictive testing for a neurogenetic disorder, and whether these psychological traits predict distress after receiving test results. Self-report scales were used to assess attachment insecurity (anxiety and avoidance) and maladaptive emotion regulation strategies (self-blame, rumination, catastrophizing) in adults at 50 % risk for Huntington's Disease (HD), Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), and Hereditary Cerebral Hemorrhage With Amyloidosis - Dutch type (HCHWA-D), when they presented for predictive testing. Distress was measured before testing and twice (within 2 months and between 6 and 8 months) after receiving test results. Pearson correlations and linear regression were used to analyze whether attachment style and emotion regulation strategies indicated distress. In 98 persons at risk for HD, CADASIL, or HCHWA-D, attachment anxiety and catastrophizing were associated with distress before predictive testing. Attachment anxiety predicted distress up to 2 months after testing. Clinicians may consider looking for signs of attachment anxiety and catastrophizing in persons who present for predictive testing, to see who may be vulnerable for distress during and after testing.

  16. The Effects of Pair Problem Solving Technique Incorporating Polya's Problem Solving Strategy on Undergraduate Students' Performance in Chemistry

    Science.gov (United States)

    Bilgin, Ibrahim

    2006-01-01

    The purpose of this study was to investigate the effects of pair problem solving technique incorporating Polya's problem solving strategy on undergraduate students' performance in conceptual and algorithmic questions in chemistry. The subjects of this study were 89 students enrolled from two first year chemistry classes. The experimental group was…

  17. The English Translation Strategies and Techniques of the Names of Tour-ist Attractions in Xi’an

    Institute of Scientific and Technical Information of China (English)

    TAO Pan

    2015-01-01

    In the translation of tourist materials, the translation of the names is the primary part. This paper aims to analyze the translation strategies and translation techniques of the names of tourist attractions. At the same time, it is aimed at awakening the cross-cultural awareness of translators and spread the distinctive culture of Xi ’an.

  18. Trading strategy based on dynamic mode decomposition: Tested in Chinese stock market

    Science.gov (United States)

    Cui, Ling-xiao; Long, Wen

    2016-11-01

    Dynamic mode decomposition (DMD) is an effective method to capture the intrinsic dynamical modes of complex system. In this work, we adopt DMD method to discover the evolutionary patterns in stock market and apply it to Chinese A-share stock market. We design two strategies based on DMD algorithm. The strategy which considers only timing problem can make reliable profits in a choppy market with no prominent trend while fails to beat the benchmark moving-average strategy in bull market. After considering the spatial information from spatial-temporal coherent structure of DMD modes, we improved the trading strategy remarkably. Then the DMD strategies profitability is quantitatively evaluated by performing SPA test to correct the data-snooping effect. The results further prove that DMD algorithm can model the market patterns well in sideways market.

  19. A novel strategy for quantitative analysis of the formulated complex system using chromatographic fingerprints combined with some chemometric techniques.

    Science.gov (United States)

    Zhong, Xuan; Yan, Jun; Li, Yan-Chun; Kong, Bo; Lu, Hong-Bing; Liang, Yi-Zeng

    2014-11-28

    In this work, a novel strategy based on chromatographic fingerprints and some chemometric techniques is proposed for quantitative analysis of the formulated complex system. Here, the formulated complex system means a formulated type of complicated analytical system containing more than one kind of raw material under some concentration composition according to a certain formula. The strategy is elaborated by an example of quantitative determination of mixtures consist of three essential oils. Three key steps of the strategy are as follows: (1) remove baselines of the chromatograms; (2) align retention time; (3) conduct quantitative analysis using multivariate regression with entire chromatographic profiles. Through the determination of concentration compositions of nine mixtures arranged by uniform design, the feasibility of the proposed strategy is validated and the factors that influence the quantitative result are also discussed. This strategy is proved to be viable and the validation indicates that quantitative result obtained using this strategy mainly depends on the efficiency of the alignment method as well as chromatographic peak shape of the chromatograms. Previously, chromatographic fingerprints were only used for identification and/or recognition of some products. This work demonstrates that with the assistance of some effective chemometric techniques, chromatographic fingerprints are also potential and promising in solving quantitative problems of complex analytical systems.

  20. Learning scientific and medical terminology with a mnemonic strategy using an illogical association technique.

    Science.gov (United States)

    Brahler, C Jayne; Walker, Diane

    2008-09-01

    For students pursuing careers in medical fields, knowledge of technical and medical terminology is prerequisite to being able to solve problems in their respective disciplines and professions. The Dean Vaughn Medical Terminology 350 Total Retention System, also known as Medical Terminology 350 (25), is a mnemonic instructional and learning strategy that combines mental imagery and keyword mnemonic elaboration processes to help students recall the scientific meaning of Greek and Latin word parts. High school students in Anatomy and Physiology classes at a career technology center were divided into experimental (Medical Terminology 350), control (rote memorization), or combination (Medical Terminology 350 and rote memorization) groups and completed pre- and posttests of standardized word recall tests. Students in the Dean Vaughn Medical Terminology 350 Total Retention System group achieved significantly greater pre- to posttest word recall improvement compared with students in both the rote memorization (P

  1. Agent based models for testing city evacuation strategies under a flood event as strategy to reduce flood risk

    Science.gov (United States)

    Medina, Neiler; Sanchez, Arlex; Nokolic, Igor; Vojinovic, Zoran

    2016-04-01

    This research explores the uses of Agent Based Models (ABM) and its potential to test large scale evacuation strategies in coastal cities at risk from flood events due to extreme hydro-meteorological events with the final purpose of disaster risk reduction by decreasing human's exposure to the hazard. The first part of the paper corresponds to the theory used to build the models such as: Complex adaptive systems (CAS) and the principles and uses of ABM in this field. The first section outlines the pros and cons of using AMB to test city evacuation strategies at medium and large scale. The second part of the paper focuses on the central theory used to build the ABM, specifically the psychological and behavioral model as well as the framework used in this research, specifically the PECS reference model is cover in this section. The last part of this section covers the main attributes or characteristics of human beings used to described the agents. The third part of the paper shows the methodology used to build and implement the ABM model using Repast-Symphony as an open source agent-based modelling and simulation platform. The preliminary results for the first implementation in a region of the island of Sint-Maarten a Dutch Caribbean island are presented and discussed in the fourth section of paper. The results obtained so far, are promising for a further development of the model and its implementation and testing in a full scale city

  2. Simulations as a guidance to support and optimize experimental techniques for ultrasonic non-destructive testing.

    OpenAIRE

    Delrue, Steven

    2011-01-01

    In today's rapidly growing industrial world where the requirement of reliability is increasing day by day and where newer and advanced materials are being introduced on a large scale, non-destructive testing (NDT) techniques have a very important role to play. The goal of NDT methodologies and techniques is to detect the presence of damage and inclusions, and to image components or structures to find defect locations, without destroying the material. Among the variety of non-destructive tes...

  3. The Role of Alternative Testing Strategies in Environmental Risk Assessment of Engineered Nanomaterials

    DEFF Research Database (Denmark)

    Hjorth, Rune; Holden, Patricia; Hansen, Steffen Foss

    2017-01-01

    Within toxicology there is a pressure to find new test systems and organisms to replace, reduce and refine animal testing. In nanoecotoxicology the need for alternative testing strategies (ATS) is further emphasized as the validity of tests and risk assessment practices developed for dissolved......) workshop in Washington, D.C. and serves as the point of depature for this paper. Here we present the main outcomes by describing and defining the use of ATS for ENMs as well as discussing its future role in environmental risk science. We conclude that diversity in testing should be encouraged to avoid...

  4. Using the Think-Aloud Technique for Determining Different Reading Strategies Used by Iranian EFL Learners

    Directory of Open Access Journals (Sweden)

    Ladan Bakhshalinezhad

    2015-06-01

    Full Text Available This study explored the reading strategies used by advanced and intermediate Persian EFL learners in both English and Persian reading comprehension texts.  Based on the aims of the study reading comprehension texts were administered to the learners and their reading strategies in both English and Persian reading comprehension texts were examined through the think-aloud method. The findings showed that while the advanced EFL learners employed all the strategies (which were included in the strategy table of the study in their English texts, the intermediate learners used only some of them and also used their strategies with different frequencies in comparison with the advanced learners. Therefore, the findings supported the view that the use of the reading strategies may be related to the learners’ proficiency level. The findings also supported the idea that reading strategies can be transferred from one language to another based on the learners’ proficiency level.Keywords: learning strategies, reading strategies, think aloud protocols, threshold level, transferability

  5. Return on engagement content strategy and web design techniques for digital marketing

    CERN Document Server

    Frick, Tim

    2014-01-01

    In the world of web design, if one wants to create a successful web site, one needs an effective content strategy. Return on Engagement shows web designers and developers how to implement an effective content strategy and how to stay ahead in the rapidly changing industry of web design. It presents best practices in terms of web design through a marketing function: content strategy, SEO, social media marketing, and success measurement to help web designers implement a strategy that ensures success for the site they are building. Return on Engagement shows web designers and d

  6. The test-retest reliability of knee joint center location techniques.

    Science.gov (United States)

    Sinclair, Jonathan; Hebron, Jack; Taylor, Paul J

    2015-04-01

    The principal source of measurement error in three-dimensional analyses is the definition of the joint center about which segmental rotations occur. The hip joint has received considerable attention in three-dimensional modeling analyses yet the reliability of the different techniques for the definition of the knee joint center has yet to be established. This study investigated the reliability of five different knee joint center estimation techniques: femoral epicondyle, femoral condyle, tibial ridge, plugin- gait, and functional. Twelve male participants walked at 1.25 m·s-1 and three-dimensional kinetics/kinematics of the knee and ankle were collected. The knee joint center was defined twice using each technique (test-and-retest) and the joint kinetic/kinematic data were applied to both. Wilcoxon rank tests and intraclass correlation coefficients (ICCs) were used to compare test and retest angular parameters and kinematic waveforms. The results show significant differences in coronal and transverse planes angulation using the tibial ridge, plug-in-gait, and functional methods. The strongest test-retest ICCs were observed for the femoral epicondyle and femoral condyle configurations. The findings from the current investigation advocate that the femoral epicondyle and femoral condyle techniques for the estimation of the knee joint center are currently the most reliable techniques.

  7. An evaluation testing technique of single event effect using Beam Blanking SEM

    Energy Technology Data Exchange (ETDEWEB)

    Aoki, J.; Hada, T.; Pesce, A.; Akutsu, T.; Matsuda, S. [National Space Development Agency of Japan, Tsukuba, Ibaraki (Japan). Tsukuba Space Center; Igarashi, T.; Baba, S.

    1997-03-01

    Beam Blanking SEM (Scanning Electron Microscope) testing technique has been applied to CMOS SRAM devices to evaluate the occurence of soft errors on memory cells. Cross-section versus beam current and LET curves derived from BBSEM and heavy ion testing technique, respectively, have been compared. A linear relation between BBSEM current and heavy ion LET has been found. The purpose of this study was to demonstrate that the application of focused pulsed electron beam could be a reliable, convenient and inexpensive tool to investigate the effects of heavy ions and high energy particles on memory devices for space application. (author)

  8. Optimal Sequential Diagnostic Strategy Generation Considering Test Placement Cost for Multimode Systems

    Directory of Open Access Journals (Sweden)

    Shigang Zhang

    2015-10-01

    Full Text Available Sequential fault diagnosis is an approach that realizes fault isolation by executing the optimal test step by step. The strategy used, i.e., the sequential diagnostic strategy, has great influence on diagnostic accuracy and cost. Optimal sequential diagnostic strategy generation is an important step in the process of diagnosis system construction, which has been studied extensively in the literature. However, previous algorithms either are designed for single mode systems or do not consider test placement cost. They are not suitable to solve the sequential diagnostic strategy generation problem considering test placement cost for multimode systems. Therefore, this problem is studied in this paper. A formulation is presented. Two algorithms are proposed, one of which is realized by system transformation and the other is newly designed. Extensive simulations are carried out to test the effectiveness of the algorithms. A real-world system is also presented. All the results show that both of them have the ability to solve the diagnostic strategy generation problem, and they have different characteristics.

  9. Optimal Sequential Diagnostic Strategy Generation Considering Test Placement Cost for Multimode Systems

    Science.gov (United States)

    Zhang, Shigang; Song, Lijun; Zhang, Wei; Hu, Zheng; Yang, Yongmin

    2015-01-01

    Sequential fault diagnosis is an approach that realizes fault isolation by executing the optimal test step by step. The strategy used, i.e., the sequential diagnostic strategy, has great influence on diagnostic accuracy and cost. Optimal sequential diagnostic strategy generation is an important step in the process of diagnosis system construction, which has been studied extensively in the literature. However, previous algorithms either are designed for single mode systems or do not consider test placement cost. They are not suitable to solve the sequential diagnostic strategy generation problem considering test placement cost for multimode systems. Therefore, this problem is studied in this paper. A formulation is presented. Two algorithms are proposed, one of which is realized by system transformation and the other is newly designed. Extensive simulations are carried out to test the effectiveness of the algorithms. A real-world system is also presented. All the results show that both of them have the ability to solve the diagnostic strategy generation problem, and they have different characteristics. PMID:26457709

  10. Sensitivity of field tests, serological and molecular techniques for Plum Pox Virus detection in various tissues

    Directory of Open Access Journals (Sweden)

    Mojca VIRŠČEK MARN

    2015-12-01

    Full Text Available Sensitivity of field tests (AgriStrip  and Immunochromato, DAS-ELISA, two step RT-PCR and real-time RT-PCR for Plum pox virus (PPV detection was tested in various tissues of apricot, peach, plum and damson plum trees infected with isolates belonging to PPV-D, PPV-M or PPV-Rec, the three strains present in Slovenia. Flowers of apricot and plum in full bloom proved to be a very good source for detection of PPV. PPV could be detected with all tested techniques in symptomatic parts of leaves in May and with one exception even in the beginning of August, but it was not detected in asymptomatic leaves using field tests, DAS-ELISA and partly also molecular techniques. PPV was detected only in some of the samples of asymptomatic parts of the leaves with symptoms and of stalks by field tests and DAS-ELISA. Infections were not detected in buds in August using field tests or DAS-ELISA. Field tests are useful for confirmation of the PPV infection in symptomatic leaves, but in tissues without symptoms DAS-ELISA should be combined or replaced by molecular techniques.

  11. FACTORS AFFECTING THE MECHANICAL PROPERTIES OF COMPACT BONE AND MINIATURE SPECIMEN TEST TECHNIQUES: A REVIEW

    Directory of Open Access Journals (Sweden)

    Vandana Chittibabu

    2016-12-01

    Full Text Available This paper presents the review concerning mechanical properties of bone and the miniature specimen test techniques. For developing a realistic understanding of how factors such as moisture content, mineralization, age, species, location, gender, rate of deformation etc. affect the mechanical properties of bone, it is critical to understand the role of these factors. A general survey on existing research work is presented on this aspect. The essential features of miniature specimen test techniques are described, along with the application of small punch test method to evaluate the mechanical behavior of materials. The procedure for the determination of tensile and fracture properties, such as: yield strength, ultimate strength, ductility, fracture toughness etc. using small punch test technique have been described. The empirical equations proposed by various investigators for the prediction of tensile and fracture properties are presented and discussed. In some cases, the predictions of material properties have been essentially made through the finite element simulation. The finite element simulation of miniature specimen test technique is also covered in this review. The use of inverse finite element procedure for the prediction of uniaxial tensile constitutive behaviour of materials is also presented

  12. Application of Optical Measurement Techniques During Fabrication and Testing of Liquid Rocket Nozzles

    Science.gov (United States)

    Gradl, Paul R.

    2015-01-01

    This paper presents a series of optical measurement techniques that were developed for use during large-scale fabrication and testing of nozzle components. A thorough understanding of hardware throughout the fabrication cycle and hotfire testing is critical to meet component design intent. Regeneratively cooled nozzles and associated tooling require tight control of tolerances during the fabrication process to ensure optimal performance. Additionally, changes in geometry during testing can affect performance of the nozzle and mating components. Structured light scanning and digital image correlation techniques were used to collect data during the fabrication and test of nozzles, in addition to other engine components. This data was used to analyze deformations data during machining, heat treatment, assembly and testing operations. A series of feasibility experiments were conducted for these techniques that led to use on full scale nozzles during the J-2X upper stage engine program in addition to other engine development programs. This paper discusses the methods and results of these measurement techniques throughout the nozzle life cycle and application to other components.

  13. Using the Think-Aloud Technique for Determining Different Reading Strategies Used by Iranian EFL Learners

    Science.gov (United States)

    Bakhshalinezhad, Ladan; Nikou, Farahnaz Reymani; Bonyadi, Alireza

    2015-01-01

    This study explored the reading strategies used by advanced and intermediate Persian EFL learners in both English and Persian reading comprehension texts. Based on the aims of the study reading comprehension texts were administered to the learners and their reading strategies in both English and Persian reading comprehension texts were examined…

  14. 76 FR 20672 - Recommendations on In Vitro Ocular Safety Testing Methods and Strategies and Routine Use of...

    Science.gov (United States)

    2011-04-13

    ... alternative testing methods and strategies proposed to further reduce and refine the use of animals for... accepted the BCOP and ICE test methods for certain regulatory testing purposes without the need for animal... for the alternative testing methods and strategies proposed to further reduce and refine the use of...

  15. Test and numerical simulation of a new type of hybrid control technique

    Institute of Scientific and Technical Information of China (English)

    Meng Qingli; Zhang Minzheng; Cheng Dong

    2005-01-01

    In this paper, a new hybrid control technique, based on a combination of base-isolation and semi-active variable stiffness/damping in a superstructure, is presented. To illustrate the efficiency of the proposed control system, model tests on a mini-electromagnetic shaking table and a numerical simulation were performed. The test and numerical calculation results indicate that this new hybrid control mode with additional damping and smaller additional stiffness can achieve a better control efficiency.

  16. Performance evaluation of multi-sensor data fusion technique for test range application

    Indian Academy of Sciences (India)

    Shrabani Bhattacharya; R Appavu Raj

    2004-04-01

    We have adopted the state-vector fusion technique for fusing multiple sensors track data to provide complete and precise trajectory information about the flight vehicle under test, for the purpose of flight safety monitoring and decisionmaking at Test Range. The present paper brings out the performance of the algorithm for different process noise and measurement noise using simulated as well as real track data.

  17. A test strategy for the assessment of additive attributed toxicity of tobacco products.

    Science.gov (United States)

    Kienhuis, Anne S; Staal, Yvonne C M; Soeteman-Hernández, Lya G; van de Nobelen, Suzanne; Talhout, Reinskje

    2016-08-01

    The new EU Tobacco Product Directive (TPD) prohibits tobacco products containing additives that are toxic in unburnt form or that increase overall toxicity of the product. This paper proposes a strategy to assess additive attributed toxicity in the context of the TPD. Literature was searched on toxicity testing strategies for regulatory purposes from tobacco industry and governmental institutes. Although mainly traditional in vivo testing strategies have been applied to assess toxicity of unburnt additives and increases in overall toxicity of tobacco products due to additives, in vitro tests combined with toxicogenomics and validated using biomarkers of exposure and disease are most promising in this respect. As such, tests are needed that are sensitive enough to assess additive attributed toxicity above the overall toxicity of tobacco products, which can associate assay outcomes to human risk and exposure. In conclusion, new, sensitive in vitro assays are needed to conclude whether comparable testing allows for assessment of small changes in overall toxicity attributed to additives. A more pragmatic approach for implementation on a short-term is mandated lowering of toxic emission components. Combined with risk assessment, this approach allows assessment of effectiveness of harm reduction strategies, including banning or reducing of additives.

  18. Cost-Effectiveness Analysis of Different Genetic Testing Strategies for Lynch Syndrome in Taiwan.

    Science.gov (United States)

    Chen, Ying-Erh; Kao, Sung-Shuo; Chung, Ren-Hua

    2016-01-01

    Patients with Lynch syndrome (LS) have a significantly increased risk of developing colorectal cancer (CRC) and other cancers. Genetic screening for LS among patients with newly diagnosed CRC aims to identify mutations in the disease-causing genes (i.e., the DNA mismatch repair genes) in the patients, to offer genetic testing for relatives of the patients with the mutations, and then to provide early prevention for the relatives with the mutations. Several genetic tests are available for LS, such as DNA sequencing for MMR genes and tumor testing using microsatellite instability and immunohistochemical analyses. Cost-effectiveness analyses of different genetic testing strategies for LS have been performed in several studies from different countries such as the US and Germany. However, a cost-effectiveness analysis for the testing has not yet been performed in Taiwan. In this study, we evaluated the cost-effectiveness of four genetic testing strategies for LS described in previous studies, while population-specific parameters, such as the mutation rates of the DNA mismatch repair genes and treatment costs for CRC in Taiwan, were used. The incremental cost-effectiveness ratios based on discounted life years gained due to genetic screening were calculated for the strategies relative to no screening and to the previous strategy. Using the World Health Organization standard, which was defined based on Taiwan's Gross Domestic Product per capita, the strategy based on immunohistochemistry as a genetic test followed by BRAF mutation testing was considered to be highly cost-effective relative to no screening. Our probabilistic sensitivity analysis results also suggest that the strategy has a probability of 0.939 of being cost-effective relative to no screening based on the commonly used threshold of $50,000 to determine cost-effectiveness. To the best of our knowledge, this is the first cost-effectiveness analysis for evaluating different genetic testing strategies for LS in

  19. Experimental Nondestructive Test for Estimation of Buckling Load on Unstiffened Cylindrical Shells Using Vibration Correlation Technique

    Directory of Open Access Journals (Sweden)

    Kaspars Kalnins

    2015-01-01

    Full Text Available Nondestructive methods, to calculate the buckling load of imperfection sensitive thin-walled structures, such as large-scale aerospace structures, are one of the most important techniques for the evaluation of new structures and validation of numerical models. The vibration correlation technique (VCT allows determining the buckling load for several types of structures without reaching the instability point, but this technique is still under development for thin-walled plates and shells. This paper presents and discusses an experimental verification of a novel approach using vibration correlation technique for the prediction of realistic buckling loads of unstiffened cylindrical shells loaded under axial compression. Four different test structures were manufactured and loaded up to buckling: two composite laminated cylindrical shells and two stainless steel cylinders. In order to characterize a relationship with the applied load, the first natural frequency of vibration and mode shape is measured during testing using a 3D laser scanner. The proposed vibration correlation technique allows one to predict the experimental buckling load with a very good approximation without actually reaching the instability point. Additional experimental tests and numerical models are currently under development to further validate the proposed approach for composite and metallic conical structures.

  20. Real-time flight test analysis and display techniques for the X-29A aircraft

    Science.gov (United States)

    Hicks, John W.; Petersen, Kevin L.

    1989-01-01

    The X-29A advanced technology demonstrator flight envelope expansion program and the subsequent flight research phase gave impetus to the development of several innovative real-time analysis and display techniques. These new techniques produced significant improvements in flight test productivity, flight research capabilities, and flight safety. These techniques include real-time measurement and display of in-flight structural loads, dynamic structural mode frequency and damping, flight control system dynamic stability and control response, aeroperformance drag polars, and aircraft specific excess power. Several of these analysis techniques also provided for direct comparisons of flight-measured results with analytical predictions. The aeroperformance technique was made possible by the concurrent development of a new simplified in-flight net thrust computation method. To achieve these levels of on-line flight test analysis, integration of ground and airborne systems was required. The capability of NASA Ames Research Center, Dryden Flight Research Facility's Western Aeronautical Test Range was a key factor to enable implementation of these methods.

  1. Metacognitive Strategies and Test Performance: An Experience Sampling Analysis of Students' Learning Behavior

    Directory of Open Access Journals (Sweden)

    Ulrike E. Nett

    2012-01-01

    Full Text Available The aim of the present study was to explore students’ learning-related cognitions prior to an in-class achievement test, with a focus on metacognitive strategy use. A sample of 70 students in grade 11 (58.6% female, Mage=17.09 years completed a series of structured, state-based measures over a two-week period via the experience sampling method until the day before a class test. Results illustrated students’ self-regulatory ability to preserve their motivational and cognitive resources, with test-related cognitions evidenced significantly more often in learning-related as opposed leisure settings. Metacognitive strategy use was also found to significantly increase as the test date approached underscoring the goal-oriented nature of situated learning behaviors. Higher intercepts and increases in frequency of test-related cognitions over time positively corresponded to test performance. Of the three metacognitive strategies assessed, monitoring was found to positively correspond with test performance. Implications for future practice as well as implications for future research employing the experience sampling method are discussed.

  2. Reducing Test Anxiety among Third Grade Students through the Implementation of Relaxation Techniques

    Science.gov (United States)

    Larson, Heidi A.; El Ramahi, Mera K.; Conn, Steven R.; Estes, Lincoln A.; Ghibellini, Amanda B.

    2010-01-01

    The purpose of this study was to reduce the negative effects that self-perceived levels of test anxiety have on third-grade students. The participants in this study consisted of 177 third-grade students at two Midwestern public elementary schools. Students at one school were taught relaxation techniques, while students at the second school served…

  3. Development of Software and Strategies for Battery Management System Testing on HIL Simulator

    DEFF Research Database (Denmark)

    Fleischer, Christian; Barreras, Jorge Varela; Christensen, Andreas Elkjær;

    2016-01-01

    In comparison with tests conducted on real Li-ion batteries, Battery Management System (BMS) tests conducted on a Hardware-In-the-Loop (HIL) battery simulator may be more cost and time effective, more flexible and traceable, easier to reproduce and safer beyond the normal range of operation....... This is particularly the case of tests at early stages in the development process or during fault simulation. However, the use of a HIL battery simulator requires the development of software (SW) and strategies for testing. While the possibilities are immense, it should be noted that the greater the level...

  4. Refinement of the wedge bar technique for compression tests at intermediate strain rates

    Directory of Open Access Journals (Sweden)

    Stander M.

    2012-08-01

    Full Text Available A refined development of the wedge-bar technique [1] for compression tests at intermediate strain rates is presented. The concept uses a wedge mechanism to compress small cylindrical specimens at strain rates in the order of 10s−1 to strains of up to 0.3. Co-linear elastic impact principles are used to accelerate the actuation mechanism from rest to test speed in under 300μs while maintaining near uniform strain rates for up to 30 ms, i.e. the transient phase of the test is less than 1% of the total test duration. In particular, a new load frame, load cell and sliding anvil designs are presented and shown to significantly reduce the noise generated during testing. Typical dynamic test results for a selection of metals and polymers are reported and compared with quasistatic and split Hopkinson pressure bar results.

  5. Optical Measurement Techniques for Rocket Engine Testing and Component Applications: Digital Image Correlation and Dynamic Photogrammetry

    Science.gov (United States)

    Gradl, Paul

    2016-01-01

    NASA Marshall Space Flight Center (MSFC) has been advancing dynamic optical measurement systems, primarily Digital Image Correlation, for extreme environment rocket engine test applications. The Digital Image Correlation (DIC) technology is used to track local and full field deformations, displacement vectors and local and global strain measurements. This technology has been evaluated at MSFC through lab testing to full scale hotfire engine testing of the J-2X Upper Stage engine at Stennis Space Center. It has been shown to provide reliable measurement data and has replaced many traditional measurement techniques for NASA applications. NASA and AMRDEC have recently signed agreements for NASA to train and transition the technology to applications for missile and helicopter testing. This presentation will provide an overview and progression of the technology, various testing applications at NASA MSFC, overview of Army-NASA test collaborations and application lessons learned about Digital Image Correlation.

  6. Development of a pseudo phased array technique using EMATs for DM weld testing

    Energy Technology Data Exchange (ETDEWEB)

    Cobb, Adam C., E-mail: adam.cobb@swri.org; Fisher, Jay L., E-mail: adam.cobb@swri.org [Southwest Research Institute, Sensor Systems and Nondestructive Technology Department, 6220 Culebra Road, San Antonio, TX 78238-5166 (United States); Shiokawa, Nobuyuki; Hamano, Toshiaki; Horikoshi, Ryoichi; Ido, Nobukazu [IHI Corporation, Nuclear Power Operations, Yokohama Engineering Center, 1, Shin-Nakahara-cho, Isogo-ku, Yokohama 235-8501 (Japan)

    2015-03-31

    Ultrasonic inspection of dissimilar metal (DM) welds in piping with cast austenitic stainless steel (CASS) has been an area ongoing research for many years given its prevalence in the petrochemical and nuclear industries. A typical inspection strategy for pipe welds is to use an ultrasonic phased array system to scan the weld from a sensor located on the outer surface of the pipe. These inspection systems generally refract either longitudinal or shear vertical (SV) waves at varying angles to inspect the weld radially. In DM welds, however, the welding process can produce a columnar grain structure in the CASS material in a specific orientation. This columnar grain structure can skew ultrasonic waves away from their intended path, especially for SV and longitudinal wave modes. Studies have shown that inspection using the shear horizontal (SH) wave mode significantly reduces the effect of skewing. Electromagnetic acoustic transducers (EMATs) are known to be effective for producing SH waves in field settings. This paper presents an inspection strategy that seeks to reproduce the scanning and imaging capabilities of a commercial phase array system using EMATs. A custom-built EMAT was used to collect data at multiple propagation angles, and a processing strategy known as the synthetic aperture focusing technique (SAFT) was used to combine the data to produce an image. Results are shown using this pseudo phased array technique to inspect samples with a DM weld and artificial defects, demonstrating the potential of this approach in a laboratory setting. Recommendations for future work to transition the technique to the field are also provided.

  7. Development of a pseudo phased array technique using EMATs for DM weld testing

    Science.gov (United States)

    Cobb, Adam C.; Fisher, Jay L.; Shiokawa, Nobuyuki; Hamano, Toshiaki; Horikoshi, Ryoichi; Ido, Nobukazu

    2015-03-01

    Ultrasonic inspection of dissimilar metal (DM) welds in piping with cast austenitic stainless steel (CASS) has been an area ongoing research for many years given its prevalence in the petrochemical and nuclear industries. A typical inspection strategy for pipe welds is to use an ultrasonic phased array system to scan the weld from a sensor located on the outer surface of the pipe. These inspection systems generally refract either longitudinal or shear vertical (SV) waves at varying angles to inspect the weld radially. In DM welds, however, the welding process can produce a columnar grain structure in the CASS material in a specific orientation. This columnar grain structure can skew ultrasonic waves away from their intended path, especially for SV and longitudinal wave modes. Studies have shown that inspection using the shear horizontal (SH) wave mode significantly reduces the effect of skewing. Electromagnetic acoustic transducers (EMATs) are known to be effective for producing SH waves in field settings. This paper presents an inspection strategy that seeks to reproduce the scanning and imaging capabilities of a commercial phase array system using EMATs. A custom-built EMAT was used to collect data at multiple propagation angles, and a processing strategy known as the synthetic aperture focusing technique (SAFT) was used to combine the data to produce an image. Results are shown using this pseudo phased array technique to inspect samples with a DM weld and artificial defects, demonstrating the potential of this approach in a laboratory setting. Recommendations for future work to transition the technique to the field are also provided.

  8. An Automatic Testing System of Scheduling Strategies in Real-Time UNIX

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    This paper proposes a formal model of the automatic testing system for scheduling strategies in real-time UNIX and describes the algorithm of the key part of the system. The model of the system is an important technology of the automatization of software development. According to the model presented in the paper, many different kinds of automatic testing systems can be designed and developed easily. At the end of the paper, the prototype proves the feasibility of the model and design.

  9. Forging partnerships that work: a strategy for near-patient testing.

    Science.gov (United States)

    Barnes, P W

    1994-01-01

    Near-patient testing systems, which bring innovative technologies to the site of patient care, also offer management challenges to effectively integrate clinical and laboratory services. A two-tiered committee structure--composed of an umbrella "advisory" organization supported by several subcommittees operating as the "working arms" of the program--offers a viable strategy to address issues involved in implementing and monitoring near-patient testing systems.

  10. Developmental toxicology: new directions workshop: refining testing strategies and study designs.

    Science.gov (United States)

    Brannen, Kimberly C; Fenton, Suzanne E; Hansen, Deborah K; Harrouk, Wafa; Kim, James H; Shuey, Dana

    2011-10-01

    In April 2009, the International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute's (HESI) Developmental and Reproductive Toxicology Technical Committee held a two-day workshop entitled "Developmental Toxicology-New Directions." The third session of the workshop focused on ways to refine animal studies to improve relevance and predictivity for human risk. The session included five presentations on: (1) considerations for refining developmental toxicology testing and data interpretation; (2) comparative embryology and considerations in study design and interpretation; (3) pharmacokinetic considerations in study design; (4) utility of genetically modified models for understanding mode-of-action; and (5) special considerations in reproductive testing for biologics. The presentations were followed by discussion by the presenters and attendees. Much of the discussion focused on aspects of refining current animal testing strategies, including use of toxicokinetic data, dose selection, tiered/triggered testing strategies, species selection, and use of alternative animal models. Another major area of discussion was use of non-animal-based testing paradigms, including how to define a "signal" or adverse effect, translating in vitro exposures to whole animal and human exposures, validation strategies, the need to bridge the existing gap between classical toxicology testing and risk assessment, and development of new technologies. Although there was general agreement among participants that the current testing strategy is effective, there was also consensus that traditional methods are resource-intensive and improved effectiveness of developmental toxicity testing to assess risks to human health is possible. This article provides a summary of the session's presentations and discussion and describes some key areas that warrant further consideration. © 2011 Wiley Periodicals, Inc.

  11. Developmental Toxicology—New Directions Workshop: Refining Testing Strategies and Study Designs

    Science.gov (United States)

    Brannen, Kimberly C.; Fenton, Suzanne E.; Hansen, Deborah K.; Harrouk, Wafa; Kim, James H.; Shuey, Dana

    2012-01-01

    In April 2009, the International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute’s (HESI) Developmental and Reproductive Toxicology Technical Committee held a two-day workshop entitled “Developmental Toxicology—New Directions.” The third session of the workshop focused on ways to refine animal studies to improve relevance and predictivity for human risk. The session included five presentations on: (1) considerations for refining developmental toxicology testing and data interpretation; (2) comparative embryology and considerations in study design and interpretation; (3) pharmacokinetic considerations in study design; (4) utility of genetically modified models for understanding mode-of-action; and (5) special considerations in reproductive testing for biologics. The presentations were followed by discussion by the presenters and attendees. Much of the discussion focused on aspects of refining current animal testing strategies, including use of toxicokinetic data, dose selection, tiered/triggered testing strategies, species selection, and use of alternative animal models. Another major area of discussion was use of non-animal-based testing paradigms, including how to define a “signal” or adverse effect, translating in vitro exposures to whole animal and human exposures, validation strategies, the need to bridge the existing gap between classical toxicology testing and risk assessment, and development of new technologies. Although there was general agreement among participants that the current testing strategy is effective, there was also consensus that traditional methods are resource-intensive and improved effectiveness of developmental toxicity testing to assess risks to human health is possible. This article provides a summary of the session’s presentations and discussion and describes some key areas that warrant further consideration. PMID:22006510

  12. Learning strategies, test anxiety and academic success of primary and high- school students at biology class

    OpenAIRE

    Stražar, Klavdija

    2016-01-01

    The extent of learning success of students in school depends upon many factors, among them are having a significant impact learning strategies and influence of test anxiety. Test anxiety refers to the anxiety that occurs in individuals in situations of assessment and evaluation in school. Anxiety in humans is expressed as a long-lasting feeling of anxiety, tension and discomfort that occurs without a specific reason. Persons who are experiencing feelings of anxiety find it difficult to face a...

  13. Operation and maintenance of waste incinerators - A comparison of two techniques and strategies; Drift och underhaall av avfallsfoerbraenningsanlaeggningar - En jaemfoerelse av tvaa tekniker och strategier

    Energy Technology Data Exchange (ETDEWEB)

    Johansson, Andreas [SP Technical Research Inst. of Sweden, Boraas (Sweden); Hoegskolan i Boraas, Boraas (Sweden); Niklasson, Fredrik [SP Technical Research Inst. of Sweden, Boraas (Sweden); Johnsson, Anders [Boraas Energi och Miljoe, Boraas (Sweden); Fredaeng, Julia [Dalkia, Stockholm (Sweden); Wettergren, Hans [Renova AB, Goeteborg (Sweden)

    2009-06-15

    This work has developed and demonstrated a simple method for comparison of operation and maintenance cost for various waste combustion techniques and plants. The principal of the method is to coarsely and initially divide cost into comparable posts. Post of specific interest is thereafter compared on a more detailed level. This procedure allows comparison with a modest consumption of time and effort. There is a lack of such comparison because of the effort needed to in detail compare the, often for each plant unique, selection of techniques and strategies. A consequence of the lack of comparisons is that success stories become invisible. The same can be said about common research needs. The demonstrated method visualizes the effects of various selections of techniques and strategies. It also points out bottlenecks for further improvement of the investigated units. The method has been simple to use and it is therefore considered as suitable to use in a larger investigation covering several waste combustion units. Thus, the project has accomplished its aims.

  14. QUANTITATIVE BUFFY COAT (QBC TEST AND OTHER DIAGNOSTIC TECHNIQUES FOR DIAGNOSIG MALARIA: REVIEW OF LITRATURE

    Directory of Open Access Journals (Sweden)

    Kuladeepa Ananda Vaidya

    2012-06-01

    Full Text Available The technical capability to perform a correct and timely diagnosis of malaria infection in an ill patient is of critical importance since symptoms of complicated malaria may suddenly develop, leading to death of the patient. Even though peripheral blood smear examination is considered as the gold standard technique, tests like Quantitative Buffy Coat (QBC test and Rapid diagnostic tests (RDTs are widely used and more sensitive in detecting malaria parasite. Here we are briefly highlighting the importance of QBC and other useful diagnostic methods for diagnosing malaria. [National J of Med Res 2012; 2(3.000: 386-388

  15. Mechanical state assessment using lamb wave technique in static tensile tests

    Science.gov (United States)

    Burkov, M. V.; Shah, R. T.; Eremin, A. V.; Byakov, A. V.; Panin, S. V.

    2016-11-01

    The paper deals with the investigation of Lamb wave ultrasonic technique for damage (or mechanical state) evaluation of AA7068T3 specimens in the course of tensile testing. Two piezoelectric transducers (PZT), one of which is used as an actuator and the other as sensor, were adhesively bonded on the specimen surface using epoxy. Two frequencies of testing signals (60 kHz and 350 kHz) were used. The set of static tensile tests were performed. The recorded signals were processed to calculate the informative parameters in order to evaluate the changes in stress-strain state of the specimens and their microstructure.

  16. Advanced Failure Determination Measurement Techniques Used in Thermal Fatigue Life Testing of Electronic Packaging

    Science.gov (United States)

    Wallace, A. P.; Cornford, S. L.; Gross, M. A.

    1996-01-01

    Thermal fatigue life testing of various electronic packaging technologies is being performed by the Reliability Technology Group at the Jet Propulsion Laboratory. These testing efforts are in progress to improve uderstanding of the reliability issues associated with low volume packaging technologies for space applications and to develop qualification and acceptance approaches for these technologies. The work described here outlines the electrical failure detection techniques used during testing by documenting the circuits and components used to make these measurements, the sensitivity of the measurements, and the applicability of each specific measurement.

  17. POC-SCALE TESTING OF OIL AGGLOMERATION TECHNIQUES AND EQUIPMENT FOR FINE COAL PROCESSING

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-01-01

    This report covers the technical progress achieved from July 01, 1997 to September 30, 1997 on the POC-Scale Testing Agglomeration Techniques and Equipment for Fine Coal Processing project. Experimental procedures and test data for recovery of fine coal from coal fines streams generated at a commercial coal preparation plant are described. Two coal fines streams, namely Sieve Bend Effluent and Cyclone Overflow were investigated. The test results showed that ash was reduced by more than 50% at combustible matter recovery levels exceeding 95%.

  18. Management strategy evaluation of pheromone-baited trapping techniques to improve management of invasive sea lamprey

    Science.gov (United States)

    Dawson, Heather; Jones, Michael L.; Irwin, Brian J.; Johnson, Nicholas; Wagner, Michael C.; Szymanski, Melissa

    2016-01-01

    We applied a management strategy evaluation (MSE) model to examine the potential cost-effectiveness of using pheromone-baited trapping along with conventional lampricide treatment to manage invasive sea lamprey. Four pheromone-baited trapping strategies were modeled: (1) stream activation wherein pheromone was applied to existing traps to achieve 10−12 mol/L in-stream concentration, (2) stream activation plus two additional traps downstream with pheromone applied at 2.5 mg/hr (reverse-intercept approach), (3) trap activation wherein pheromone was applied at 10 mg/hr to existing traps, and (4) trap activation and reverse-intercept approach. Each new strategy was applied, with remaining funds applied to conventional lampricide control. Simulating deployment of these hybrid strategies on fourteen Lake Michigan streams resulted in increases of 17 and 11% (strategies 1 and 2) and decreases of 4 and 7% (strategies 3 and 4) of the lakewide mean abundance of adult sea lamprey relative to status quo. MSE revealed performance targets for trap efficacy to guide additional research because results indicate that combining lampricides and high efficacy trapping technologies can reduce sea lamprey abundance on average without increasing control costs.

  19. Thyroid in a jar: towards an integrated in vitro testing strategy for thyroid-active compounds

    NARCIS (Netherlands)

    Jomaa, B.

    2015-01-01

      Jomaa, B. (2015). Thyroid in a Jar: Towards an Integrated In Vitro Testing Strategy for Thyroid-Active Compounds. PhD thesis, Wageningen University, the Netherlands Abstract The aim of this thesis was to find in vitro and toxicogenomics-based alternatives to

  20. Cognitive Learning Strategy as a Partial Effect on Major Field Test in Business Results

    Science.gov (United States)

    Strang, Kenneth David

    2014-01-01

    An experiment was developed to determine if cognitive learning strategies improved standardized university business exam results. Previous studies revealed that factors such as prior ability, age, gender, and culture predicted a student's Major Field Test in Business (MFTB) score better than course content. The experiment control consisted of…

  1. Towards a four technique GGOS site: VLBI - DORIS compatibility tests at Wettzell

    Science.gov (United States)

    Klügel, Thomas; Didelot, Francois; Kodet, Jan; Kronschnabl, Gerhard; Mähler, Swetlana; Neidhardt, Alexander; Plötz, Christian; Saunier, Jérôme; Schüler, Torben; Walter, Jean-Marc

    2016-04-01

    Within the framework of a Global Geodetic Observing System (GGOS), co-location sites are of special importance for the evaluation and mutual control of the individual geodetic space techniques. At the Geodetic Observatory Wettzell a DORIS (Doppler Orbitography and Radiopositioning Integrated by Satellite) beacon could complete the geodetic instrumentation consisting of three Very Long Baseline Interferometry (VLBI) telescopes, two Laser Ranging (LR) systems and a number of multi- Global Navigation Satellite System (GNSS) stations. Integrating all fourth geodetic instrumentation into one site generates new problems with Electromagnetic Compatibility (EMC). While the VLBI system is designed to receive very weak signals from quasars, the DORIS beacon emits strong signals in the UHF frequency band at 401.25 MHz and in the S band at 2036.25 MHz. During the observation of quasars with VLBI there is a high risk of coupling DORIS S band signals into the VLBI receiving chain generating spurious signal and, in the worst case, overloading receiving chain electronics and risking its damage. Before a DORIS beacon is operated at the Geodetic Observatory Wettzell, it must be ensured that it can be operated alongside the VLBI system without any risk of damage or degradation of the measurement. Field tests under different setups were performed to assess the impact of the DORIS signal on the classical geodetic VLBI 20-m and the VGOS 13-m radio telescopes. Different locations on the observatory each at a distance of more than 100 m were occupied by the DORIS antenna. It has been shown that obstacles like buildings or earth mounds attenuate the signal up to 20 dB. However the power received at the input of the Low Noise Amplifiers (LNA) is still at a critical level when the radio telescope points towards the DORIS beacon. The quality of the correlated signals is not or barely affected at long baselines. At local baselines however, the DORIS emission as a common mode signal degrades

  2. Current situation of endoscopic biliary cannulation and salvage techniques for difficult cases: Current strategies in Japan.

    Science.gov (United States)

    Yasuda, Ichiro; Isayama, Hiroyuki; Bhatia, Vikram

    2016-04-01

    In the pancreatobiliary session at Endoscopic Forum Japan (EFJ) 2015, current trends of routine biliary cannulation techniques and salvage techniques for difficult biliary cannulation cases were discussed. Endoscopists from nine Japanese high-volume centers along with two overseas centers participated in the questionnaires and discussion. It was concluded that, currently, in Western countries, the wire-guided cannulation (WGC) technique is favored during initial cannulation attempts. However, the conventional technique using an endoscopic retrograde cholangiopancreatography catheter with contrast medium injection is still used as first choice at most Japanese high-volume centers. The WGC technique is used as the second choice at some institutions only. After failed biliary cannulation attempts, the initial salvage option preferred in most centers includes pancreatic guidewire placement, followed by precut techniques as the second salvage choice. Among several precut techniques, the free-hand needle knife sphincterotomy with cutting upwards from the pancreatic duct is most popular. Endoscopic ultrasonography-guided rendezvous technique is also carried out as a final salvage option at select institutions.

  3. Leak testing of bubble-tight dampers using tracer gas techniques

    Energy Technology Data Exchange (ETDEWEB)

    Lagus, P.L. [Lagus Applied Technology, Inc., San Diego, CA (United States); DuBois, L.J. [Commonwealth Edison, Zion, IL (United States); Fleming, K.M. [NCS Corporation, Columbus, OH (United States)] [and others

    1995-02-01

    Recently tracer gas techniques have been applied to the problem of measuring the leakage across an installed bubble-tight damper. A significant advantage of using a tracer gas technique is that quantitative leakage data are obtained under actual operating differential pressure conditions. Another advantage is that leakage data can be obtained using relatively simple test setups that utilize inexpensive materials without the need to tear ducts apart, fabricate expensive blank-off plates, and install test connections. Also, a tracer gas technique can be used to provide an accurate field evaluation of the performance of installed bubble-tight dampers on a periodic basis. Actual leakage flowrates were obtained at Zion Generating Station on four installed bubble-tight dampers using a tracer gas technique. Measured leakage rates ranged from 0.01 CFM to 21 CFM. After adjustment and subsequent retesting, the 21 CFM damper leakage was reduced to a leakage of 3.8 CFM. In light of the current regulatory climate and the interest in Control Room Habitability issues, imprecise estimates of critical air boundary leakage rates--such as through bubble-tight dampers--are not acceptable. These imprecise estimates can skew radioactive dose assessments as well as chemical contaminant exposure calculations. Using a tracer gas technique, the actual leakage rate can be determined. This knowledge eliminates a significant source of uncertainty in both radioactive dose and/or chemical exposure assessments.

  4. Integrating complementary medicine literacy education into Australian medical curricula: Student-identified techniques and strategies for implementation.

    Science.gov (United States)

    Templeman, Kate; Robinson, Anske; McKenna, Lisa

    2015-11-01

    Formal medical education about complementary medicine (CM) that comprises medicinal products/treatments is required due to possible CM interactions with conventional medicines; however, few guidelines exist on design and implementation of such education. This paper reports findings of a constructivist grounded theory method study that identified key strategies for integrating CM literacy education into medical curricula. Analysis of data from interviews with 30 medical students showed that students supported a longitudinal integrative and pluralistic approach to medicine. Awareness of common patient use, evidence, and information relevant to future clinical practice were identified as focus points needed for CM literacy education. Students advocated for interactive case-based, experiential and dialogical didactic techniques that are multiprofessional and student-centred. Suggested strategies provide key elements of CM literacy within research, field-based practice, and didactic teaching over the entirety of the curriculum. CM educational strategies should address CM knowledge deficits and ultimately respond to patients' needs.

  5. [The quantitative testing of V617F mutation in gen JAK2 using pyrosequencing technique].

    Science.gov (United States)

    Dunaeva, E A; Mironov, K O; Dribnokhodova, T E; Subbotina, E E; Bashmakova; Ol'hovskiĭ, I A; Shipulin, G A

    2014-11-01

    The somatic mutation V617F in gen JAK2 is a frequent cause of chronic myeloprolific diseases not conditioned by BCR/ABL mutation. The quantitative testing of relative percentage of mutant allele can be used in establishing severity of disease and its prognosis and in prescription of remedy inhibiting activity of JAK2. To quantitatively test mutation the pyrosequencing technique was applied. The developed technique permits detecting and quantitatively, testing percentage of mutation fraction since 7%. The "gray zone" is presented by samples with percentage of mutant allele from 4% to 7%. The dependence of expected percentage of mutant fraction in analyzed sample from observed value of signal is described by equation of line with regression coefficients y = - 0.97, x = -1.32 and at that measurement uncertainty consists ± 0.7. The developed technique is approved officially on clinical material from 192 patients with main forms of myeloprolific diseases not conditioned by BCR/ABL mutation. It was detected 64 samples with mautant fraction percentage from 13% to 91%. The developed technique permits implementing monitoring of therapy of myeloprolific diseases and facilitates to optimize tactics of treatment.

  6. A Predicate Based Fault Localization Technique Based On Test Case Reduction

    Directory of Open Access Journals (Sweden)

    Rohit Mishra

    2015-08-01

    Full Text Available ABSTRACT In todays world software testing with statistical fault localization technique is one of most tedious expensive and time consuming activity. In faulty program a program element contrast dynamic spectra that estimate location of fault. There may have negative impact from coincidental correctness with these technique because in non failed run the fault can also be triggered out and if so disturb the assessment of fault location. Now eliminating of confounding rules on the recognizing the accuracy. In this paper coincidental correctness which is an effective interface is the reason of success of fault location. We can find out fault predicates by distribution overlapping of dynamic spectrum in failed runs and non failed runs and slacken the area by referencing the inter class distances of spectra to clamp the less suspicious candidate. After that we apply coverage matrix base reduction approach to reduce the test cases of that program and locate the fault in that program. Finally empirical result shows that our technique outshine with previous existing predicate based fault localization technique with test case reduction.

  7. Strategy for a Rock Mechanics Site Descriptive Model. A test case based on data from the Aespoe HRL

    Energy Technology Data Exchange (ETDEWEB)

    Hudson, John A (ed.) [Rock Engineering Consultants, Welwyn Garden City (United Kingdom)

    2002-06-01

    In anticipation of the SKB Site Investigations for radioactive waste disposal, an approach has been developed for the Rock Mechanics Site Descriptive Model. This approach was tested by predicting the rock mechanics properties of a 600 m x 180 m x 120 m rock volume at the Aespoe Hard Rock Laboratory (HRL) using limited borehole data of the type typically obtained during a site investigation. These predicted properties were then compared with 'best estimate' properties obtained from a study of the test rock volume using additional information, mainly tunnel data. The exercise was known as the Test Case, and is the subject of this Report. Three modelling techniques were used to predict the rock properties: the 'empirical approach' - the rock properties were estimated using rock mass classification schemes and empirical correlation formulae; the 'theoretical approach' - the rock properties were estimated using numerical modelling techniques; and the 'stress approach' - the rock stress state was estimated using primary data and numerical modelling. These approaches are described separately and respectively. Following an explanation of the context for the Test Case within the strategy for developing the Rock Mechanics Site Descriptive Model, conditions at the Aespoe HRL are described in Chapter 2. The Test Case organization and the suite of nine Protocols used to ensure that the work was appropriately guided and co-ordinated are described in Chapter 3. The methods for predicting the rock properties and the rock stress, and comparisons with the 'best estimate' properties of the actual conditions, are presented in Chapters 4 and 5. Finally, the conclusions from this Test Case exercise are given in Chapter 6. General recommendations for the management of this type of Test Case are also included.

  8. FPGA techniques based new hybrid modulation strategies for voltage source inverters.

    Science.gov (United States)

    Sudha, L U; Baskaran, J; Elankurisil, S A

    2015-01-01

    This paper corroborates three different hybrid modulation strategies suitable for single-phase voltage source inverter. The proposed method is formulated using fundamental switching and carrier based pulse width modulation methods. The main tale of this proposed method is to optimize a specific performance criterion, such as minimization of the total harmonic distortion (THD), lower order harmonics, switching losses, and heat losses. The proposed method is articulated using fundamental switching and carrier based pulse width modulation methods. Thus, the harmonic pollution in the power system will be reduced and the power quality will be augmented with better harmonic profile for a target fundamental output voltage. The proposed modulation strategies are simulated in MATLAB r2010a and implemented in a Xilinx spartan 3E-500 FG 320 FPGA processor. The feasibility of these modulation strategies is authenticated through simulation and experimental results.

  9. Adaptation of Crack Growth Detection Techniques to US Material Test Reactors

    Energy Technology Data Exchange (ETDEWEB)

    A. Joseph Palmer; Sebastien P. Teysseyre; Kurt L. Davis; Joy L. Rempe; Gordon Kohse; Yakov Ostrovsky; David M. Carpenter

    2014-04-01

    A key component in evaluating the ability of Light Water Reactors to operate beyond 60 years is characterizing the degradation of materials exposed to radiation and various water chemistries. Of particular concern is the response of reactor materials to Irradiation Assisted Stress Corrosion Cracking (IASCC). Some materials testing reactors (MTRs) outside the U.S., such as the Halden Boiling Water Reactor (HBWR), have deployed a technique to measure crack growth propagation during irradiation. This technique incorporates a compact loading mechanism to stress the specimen during irradiation. A crack in the specimen is monitored using the Direct Current Potential Drop (DCPD) method. A project is underway to develop and demonstrate the performance of a similar type of test rig for use in U.S. MTRs. The first year of this three year project was devoted to designing, analyzing, fabricating, and bench top testing a mechanism capable of applying a controlled stress to specimens while they are irradiated in a pressurized water loop (simulating PWR reactor conditions). During the second year, the mechanism will be tested in autoclaves containing high pressure, high temperature water with representative water chemistries. In addition, necessary documentation and safety reviews for testing in a reactor environment will be completed. In the third year, the assembly will be tested in the Massachusetts Institute of Technology Reactor (MITR) and Post Irradiation Examinations (PIE) will be performed.

  10. Modelling and operation strategies of DLR's large scale thermocline test facility (TESIS)

    Science.gov (United States)

    Odenthal, Christian; Breidenbach, Nils; Bauer, Thomas

    2017-06-01

    In this work an overview of the TESIS:store thermocline test facility and its current construction status will be given. Based on this, the TESIS:store facility using sensible solid filler material is modelled with a fully transient model, implemented in MATLAB®. Results in terms of the impact of filler site and operation strategies will be presented. While low porosity and small particle diameters for the filler material are beneficial, operation strategy is one key element with potential for optimization. It is shown that plant operators have to ponder between utilization and exergetic efficiency. Different durations of the charging and discharging period enable further potential for optimizations.

  11. Testing strategies to establish the safety of nanomaterials: conclusions of an ECETOC workshop.

    Science.gov (United States)

    Warheit, David B; Borm, Paul J A; Hennes, Christa; Lademann, Jürgen

    2007-06-01

    portable, and less expensive than the currently available state of the art instrumentation. With regard to a general testing approach for human health hazard evaluation of nanoparticles, a first step to determine potency may include a prioritization-related in vitro screening strategy to assess the possible reactivity, biomarkers of inflammation and cellular uptake of nanoparticles; however this process should be validated using in vivo techniques. A Tier 1 in vivo testing strategy could include a short-term inhalation or intratracheal instillation of nanoparticles as the route of exposure in the lungs of rats or mice. The endpoints that should be assessed include indices of lung inflammation, cytotoxicity, and cell proliferation, as well as histopathology of the respiratory tract and the major extrapulmonary organs. For Tier 2 in vivo testing for hazard identification, a longer term inhalation study is recommended, and this would include more substantive mechanistic endpoints such as determination of particle deposition, translocation, and disposition within the body. Additional studies could be designed with specific animal models to mimic sensitive populations. With regard to dermal exposures, currently there is little evidence that nanoparticles at a size exceeding 100 nm penetrate through the skin barrier into the living tissue (i.e., dermal compartment). The penetration of nanoparticles at a size less than 100 nm should be a topic of further investigation. Moreover, considering the impacts of dermal exposures and corresponding hazard potential of nanoparticles, it must be taken into consideration that the dermal uptake of nanoparticles will be an order of magnitude smaller than the uptake via the inhalation or oral routes of exposure. For the evaluation of the health risk of nanoparticles, it has to be determined whether they are harmful to living cells and whether, under real conditions, they penetrate through the skin barrier into the living tissue. For the

  12. An economic analysis of hyperketonemia testing and propylene glycol treatment strategies in early lactation dairy cattle.

    Science.gov (United States)

    McArt, J A A; Nydam, D V; Oetzel, G R; Guard, C L

    2014-11-01

    The purpose was to develop stochastic economic models which address variation in disease risks and costs in order to evaluate different simulated on-farm testing and propylene glycol (PG) treatment strategies based on herd hyperketonemia (HYK) incidence during the first 30 DIM. Data used in model development concerning the difference in health and production consequences between HYK and non-ketotic cows were based on results from 10 studies representing over 13,000 cows from 833 dairy farms in North America, Canada, and Europe. Inputs for PG associated variables were based on a large field trial using cows from 4 free-stall dairy herds (2 in New York and 2 in Wisconsin). Four simulated on-farm testing and treatment strategies were analyzed at herd HYK incidences ranging from 5% to 80% and included: 1) treating all cows with 5d of PG starting at 5 DIM, 2) testing all cows for HYK 1 day per week (e.g. Mondays) from 3 to 16 DIM and treating all positive cows with 5d of oral PG, 3) testing all cows for HYK 2 days per week (e.g. Mondays and Thursdays) from 3 to 9 DIM and treating all positive cows with 5d of oral PG, and 4) testing all cows for HYK 3 days per week (e.g. Mondays, Wednesdays, and Fridays) from 3 to 16 DIM and treating all positive cows with 5d of oral PG. Cost-benefit analysis included the costs associated with labor to test cows, β-hydroxybutyrate test strips, labor to treat cows, PG, and the associated gain in milk production, decrease in DA and early removal risks of PG treated HYK positive cows compared to non-treated HYK positive cows. Stochastic models were developed to account for variability in the distribution of input variables. Per 100 fresh cows in a herd with an HYK incidence of 40%, the mean economic benefits of the 4 different strategies were $1088, $744, $1166, and $760, respectively. Testing cows 2 days per week from 3 to 9 DIM was the most cost-effective strategy for herds with HYK incidences between 15% and 50%; above 50%, treating all

  13. Dental Student Study Strategies: Are Self-Testing and Scheduling Related to Academic Performance?

    Science.gov (United States)

    McAndrew, Maureen; Morrow, Christina S; Atiyeh, Lindsey; Pierre, Gaëlle C

    2016-05-01

    Self-testing, a strategy wherein a student actively engages in creating questions and answers from study materials to assist with studying, has been found to be especially advantageous because it enhances future retrieval of information. Studies have found correlations among students' grade point averages (GPAs), self-testing, and rereading study strategies, as well as the spacing of study sessions over time. The aim of this study was to assess relationships among dental students' study strategies, scheduling of study time, and academic achievement. A 16-item survey requesting information on study habits, study schedules, and GPAs was distributed to 358 second-year dental students at New York University College of Dentistry. Additionally, the survey asked students to report the average number of hours per week they devoted to studying for didactic courses and preparing for hands-on preclinical courses. Of the 358 students, 94 (26%) responded to the survey. The vast majority of the respondents reported utilizing self-testing and rereading study strategies. High performers (with higher GPAs) were more likely to use self-testing, especially with flashcards, and to space their studying over multiple sessions. Lower performing students were more likely to highlight or underline their notes and to mass their study sessions or cram. Longer hours devoted to studying and practicing for simulation courses were associated with stronger performance; lower performers reported spending significantly fewer hours practicing for simulation courses. Half of the dental students surveyed said that they felt their studying would be more productive in the morning, although 84% reported doing most of their studying in the evening or late night. Sound study decisions depend on accurate regulation of ongoing learning and appropriate use and timing of evidence-based study strategies, so these results suggest that dental students may require guidance in these areas.

  14. Test technique development in interference free testing, flow visualization, and remote control model technology at Langley's Unitary Plan wind tunnel

    Science.gov (United States)

    Corlett, W. A.

    1979-01-01

    A metric half-span model is considered as a means of mechanical support for a wind-tunnel model which allows measurement of aerodynamic forces and moments without support interference or model distortion. This technique can be applied to interference-free propulsion models. The vapor screen method of flow visualization at supersonic Mach numbers is discussed. The use of smoke instead of water vapor as a medium to produce the screen is outlined. Vapor screen data are being used in the development of analytical vortex tracking programs. Test results for a remote control model system are evaluated. Detailed control effectiveness and cross-coupling data were obtained with a single run. For the afterbody tail configuration, tested control boundaries at several roll orientations were established utilizing the facility's on-line capability to 'fly' the model in the wind tunnel.

  15. Phototoxicity of bergamot oil assessed by in vitro techniques in combination with human patch tests.

    Science.gov (United States)

    Kejlová, K; Jírová, D; Bendová, H; Kandárová, H; Weidenhoffer, Z; Kolárová, H; Liebsch, M

    2007-10-01

    The aim of this study was to clarify the differences in the phototoxicity of bergamot oil obtained from four different suppliers. Spectral and chemical analyses were performed to identify presence of photoactive compounds in the test samples. The phototoxicity was assessed in vitro by the 3T3 NRU phototoxicity test (PT) and subsequently in a phototoxicity test on reconstructed human skin model (H3D PT). Confirmatory photopatch tests in a group of volunteers were performed using the first non-phototoxic concentration determined in the H3D PT. The spectral and chemical analyses revealed, that two samples of bergamot oil exhibited a potential for photoactivation. These oils were subsequently classified as phototoxic in the 3T3 NRU PT, however, only on the basis of borderline results and depending on the solvent used. H3D PT revealed clear classifications, correlating well with the findings of spectral and chemical analysis. The test was, however, not yet capable of precise prediction of safe, non-phototoxic concentrations. Additional endpoints, e.g. interleukin determination might be employed to increase the sensitivity of the test. Although the study showed the usefulness of the tiered testing strategy, currently, the extrapolation of in vitro results to human situation may be performed only to a limited extent.

  16. Processing techniques for data from the Kuosheng Unit 1 shakedown safety-relief-valve tests

    Energy Technology Data Exchange (ETDEWEB)

    McCauley, E.W.; Rompel, S.L.; Weaver, H.J.; Altenbach, T.J.

    1982-08-01

    This report describes techniques developed at the Lawrence Livermore National Laobratory, Livermore, CA for processing original data from the Taiwan Power Company's Kuosheng MKIII Unit 1 Safety Relief Valve Shakedown Tests conducted in April/May 1981. The computer codes used, TPSORT, TPPLOT, and TPPSD, form a special evaluation system for treating the data from its original packed binary form to ordered, calibrated ASCII transducer files and then to production of time-history plots, numerical output files, and spectral analyses. Using the data processing techniques described, a convenient means of independently examining and analyzing a unique data base for steam condensation phenomena in the MARKIII wetwell is described. The techniques developed for handling these data are applicable to the treatment of similar, but perhaps differently structured, experiment data sets.

  17. COMPARISON OF SQL INJECTION DETECTION TECHNIQUES WHICH USES CHI-SQUARE TEST

    Directory of Open Access Journals (Sweden)

    KHWAIRAKPAM AMITAB,

    2011-06-01

    Full Text Available Database driven by interactive web applications are at risk of SQL Injection Attacks (SQLIA these applications accept user inputs and use them to form SQL statements. During SQL injection process the attacker inputs malicious SQL query segments which will result in different database request. SQLIA can be use to bypass authentication control and also extract and/or modify valuable information. In order to encounter such type of threats different techniques are purposed by researchers but most of the implemented approaches which usesanomaly detection model have very high false alert. In this paper we have analyze existing detection techniques that uses Chi-square test. And we have evaluated these techniques against SQLIA.

  18. Testing of a technique for remotely measuring water salinity in an estuarine environment

    Science.gov (United States)

    Thomann, G. C.

    1975-01-01

    An aircraft experiment was flown on November 7, 1973 to test a technique for remote water salinity measurement. Apparent temperatures at 21 cm and 8-14 micron wavelengths were recorded on eight runs over a line along which the salinity varied from 5 to 30%. Boat measurements were used for calibration and accuracy calculations. Overall RMS accuracy over the complete range of salinities was 3.6%. Overall RMS accuracy for salinities greater than 10%, where the technique is more sensitive, was 2.6%. Much of this error is believed to be due to inability to exactly locate boat and aircraft positions. The standard deviation over the eight runs for salinities or = 10% is 1.4%; this error contains a component due to mislocation of the aircraft also. It is believed that operational use of the technique is possible with accuracies of 1-2%.

  19. Growth Strategies in the Publishing Industry through the Betterment of Managerial Techniques

    Directory of Open Access Journals (Sweden)

    Bogdan Cojocea

    2008-10-01

    Full Text Available The publishing industry is one of the branches of the national economy which thoroughly follows the rules of efficiency and strategic thinking specific to the economic area. In this context, it is useful for any publishing company to define its own economic strategy based on specific objectives and priorities which would lead to improved performance, market share and notoriety.

  20. Twenty-Two Years of Training Social Work Practitioners in Africa: Reflections on Strategies and Techniques

    Science.gov (United States)

    Mupedziswa, Rodreck

    2008-01-01

    Reminisces on teaching social work from the baccalaureate through the doctoral level for more than two decades, with special attention to comparing classroom teaching and field work supervision; provides an overview of strategies of the lecture methods which have been found to be successful; also discusses methods such as small group interaction,…

  1. Phased array ultrasonic testing of dissimilar metal welds using geometric based referencing delay law technique

    Science.gov (United States)

    Han, Taeyoung; Schubert, Frank; Hillmann, Susanne; Meyendorf, Norbert

    2015-03-01

    Phased array ultrasonic testing (PAUT) techniques are widely used for the non-destructive testing (NDT) of austenitic welds to find defects like cracks. However, the propagation of ultrasound waves through the austenitic material is intricate due to its inhomogeneous and anisotropic nature. Such a characteristic leads beam path distorted which causes the signal to be misinterpreted. By employing a reference block which is cutout from the mockup of which the structure is a dissimilar metal weld (DMW), a new method of PAUT named as Referencing Delay Law Technique (RDLT) is introduced. With the RDLT, full matrix capture (FMC) was used for data acquisition. To reconstruct the images, total focusing method (TFM) was used. After the focal laws were calculated, PAUT was then performed. As a result, the flaws are more precisely positioned with significantly increased signal-to-noise ratio (SNR).

  2. Comparative Study on the Different Testing Techniques in Tree Classification for Detecting the Learning Motivation

    Science.gov (United States)

    Juliane, C.; Arman, A. A.; Sastramihardja, H. S.; Supriana, I.

    2017-03-01

    Having motivation to learn is a successful requirement in a learning process, and needs to be maintained properly. This study aims to measure learning motivation, especially in the process of electronic learning (e-learning). Here, data mining approach was chosen as a research method. For the testing process, the accuracy comparative study on the different testing techniques was conducted, involving Cross Validation and Percentage Split. The best accuracy was generated by J48 algorithm with a percentage split technique reaching at 92.19 %. This study provided an overview on how to detect the presence of learning motivation in the context of e-learning. It is expected to be good contribution for education, and to warn the teachers for whom they have to provide motivation.

  3. Field test of radioactive high efficiency filter and filter exchange techniques of fuel cycle examination facility

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Yong Hwa; Lee, Hyung Kwon; Chun, Young Bum; Park, Dae Gyu; Ahn, Sang Bok; Chu, Yong Sun; Kim, Eun Ka

    1997-12-01

    The development of high efficiency filter was started to protect human beings from the contamination of radioactive particles, toxic gases and bacillus, and its gradual performance increment led to the fabrication of Ultra Low Penetration Air Filter (ULPA) today. The application field of ULPA has been spread not only to the air conditioning of nuclear power facilities, semiconductor industries, life science, optics, medical care and general facilities but also to the core of ultra-precision facilities. Periodic performance test on the filters is essential to extend its life-time through effective maintenance. Especially, the bank test on HEPA filter of nuclear facilities handling radioactive materials is required for environmental safety. Nowadays, the bank test technology has been reached to the utilization of a minimized portable detecting instruments and the evaluation techniques can provide high confidence in the area of particle distribution and leakage test efficiency. (author). 16 refs., 13 tabs., 14 figs.

  4. Testing isotropy of the universe using the Ramsey resonance technique on ultracold neutron spins

    CERN Document Server

    Altarev, I; Bison, G; Bodek, K; Daum, M; Fertl, M; Fierlinger, P; Franke, B; Gutsmiedl, E; Heil, W; Henneck, R; Horras, M; Khomutov, N; Kirch, K; Kistryn, S; Kraft, A; Knecht, A; Knowles, P; Kozela, A; Lauer, T; Lauss, B; Lefort, T; Lemière, Y; Mtchedlishvili, A; Naviliat-Cuncic, O; Pazgalev, A; Petzoldt, G; Piegsa, F M; Pierre, E; Pignol, G; Quéméner, G; Rebetez, M; Rebreyend, D; Roccia, S; Schmidt-Wellenburg, P; Severijns, N; Sobolev, Yu; Weis, A; Zejma, J; Zenner, J; Zsigmond, G

    2010-01-01

    Physics at the Planck scale could be revealed by looking for tiny violations of fundamental symmetries in low energy experiments. In 2008, a sensitive test of the isotropy of the Universe using has been performed with stored ultracold neutrons (UCN), this is the first clock-comparison experiment performed with free neutrons. During several days we monitored the Larmor frequency of neutron spins in a weak magnetic field using the Ramsey resonance technique. An non-zero cosmic axial field, violating rotational symmetry, would induce a daily variation of the precession frequency. Our null result constitutes one of the most stringent tests of Lorentz invariance to date.

  5. Testing equipment and experimental techniques for the investigation of the photoviscoelastic behaviour of soft polymers

    Energy Technology Data Exchange (ETDEWEB)

    Weber, H.

    Creep tests with uniaxial stress and pure shear have been carried out in order to determine the behaviour of soft plastics, which is governed by a non-linear material law, and to apply it to the photoelastic analysis of biaxial stress in plastic components under quasistatic and isothermal loads. The test facility is described as well as the technique applied to correct stress/creep curves for sigma=const. Results are presented for plane and tubular samples of soft PVC and an unsaturated polyester.

  6. Hybrid Model Testing Technique for Deep-Sea Platforms Based on Equivalent Water Depth Truncation

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    In this paper, an inner turret moored FPSO which works in the water of 320 m depth, is selected to study the so-called "passively-truncated + numerical-simulation" type of hybrid model testing technique while the truncated water depth is 160 m and the model scale λ=80. During the investigation, the optimization design of the equivalent-depth truncated system is performed by using the similarity of the static characteristics between the truncated system and the full depth one as the objective function. According to the truncated system, the corresponding physical test model is made. By adopting the coupling time domain simulation method, the truncated system model test is numerically reconstructed to carefully verify the computer simulation software and to adjust the corresponding hydrodynamic parameters. Based on the above work, the numerical extrapolation to the full depth system is performed by using the verified computer software and the adjusted hydrodynamic parameters. The full depth system model test is then performed in the basin and the results are compared with those from the numerical extrapolation. At last, the implementation procedure and the key technique of the hybrid model testing of the deep-sea platforms are summarized and printed. Through the above investigations, some beneficial conclusions are presented.

  7. Digital Image Correlation Techniques Applied to Large Scale Rocket Engine Testing

    Science.gov (United States)

    Gradl, Paul R.

    2016-01-01

    Rocket engine hot-fire ground testing is necessary to understand component performance, reliability and engine system interactions during development. The J-2X upper stage engine completed a series of developmental hot-fire tests that derived performance of the engine and components, validated analytical models and provided the necessary data to identify where design changes, process improvements and technology development were needed. The J-2X development engines were heavily instrumented to provide the data necessary to support these activities which enabled the team to investigate any anomalies experienced during the test program. This paper describes the development of an optical digital image correlation technique to augment the data provided by traditional strain gauges which are prone to debonding at elevated temperatures and limited to localized measurements. The feasibility of this optical measurement system was demonstrated during full scale hot-fire testing of J-2X, during which a digital image correlation system, incorporating a pair of high speed cameras to measure three-dimensional, real-time displacements and strains was installed and operated under the extreme environments present on the test stand. The camera and facility setup, pre-test calibrations, data collection, hot-fire test data collection and post-test analysis and results are presented in this paper.

  8. Techniques and Methods for Testing the Postural Function in Healthy and Pathological Subjects.

    Science.gov (United States)

    Paillard, Thierry; Noé, Frédéric

    2015-01-01

    The different techniques and methods employed as well as the different quantitative and qualitative variables measured in order to objectify postural control are often chosen without taking into account the population studied, the objective of the postural test, and the environmental conditions. For these reasons, the aim of this review was to present and justify the different testing techniques and methods with their different quantitative and qualitative variables to make it possible to precisely evaluate each sensory, central, and motor component of the postural function according to the experiment protocol under consideration. The main practical and technological methods and techniques used in evaluating postural control were explained and justified according to the experimental protocol defined. The main postural conditions (postural stance, visual condition, balance condition, and test duration) were also analyzed. Moreover, the mechanistic exploration of the postural function often requires implementing disturbing postural conditions by using motor disturbance (mechanical disturbance), sensory stimulation (sensory manipulation), and/or cognitive disturbance (cognitive task associated with maintaining postural balance) protocols. Each type of disturbance was tackled in order to facilitate understanding of subtle postural control mechanisms and the means to explore them.

  9. Determination of a quantitative parameter to evaluate swimming technique based on the maximal tethered swimming test.

    Science.gov (United States)

    Soncin, Rafael; Mezêncio, Bruno; Ferreira, Jacielle Carolina; Rodrigues, Sara Andrade; Huebner, Rudolf; Serrão, Julio Cerca; Szmuchrowski, Leszek

    2017-06-01

    The aim of this study was to propose a new force parameter, associated with swimmers' technique and performance. Twelve swimmers performed five repetitions of 25 m sprint crawl and a tethered swimming test with maximal effort. The parameters calculated were: the mean swimming velocity for crawl sprint, the mean propulsive force of the tethered swimming test as well as an oscillation parameter calculated from force fluctuation. The oscillation parameter evaluates the force variation around the mean force during the tethered test as a measure of swimming technique. Two parameters showed significant correlations with swimming velocity: the mean force during the tethered swimming (r = 0.85) and the product of the mean force square root and the oscillation (r = 0.86). However, the intercept coefficient was significantly different from zero only for the mean force, suggesting that although the correlation coefficient of the parameters was similar, part of the mean velocity magnitude that was not associated with the mean force was associated with the product of the mean force square root and the oscillation. Thus, force fluctuation during tethered swimming can be used as a quantitative index of swimmers' technique.

  10. POC-SCALE TESTING OF AN ADVANCED FINE COAL DEWATERING EQUIPMENT/TECHNIQUE

    Energy Technology Data Exchange (ETDEWEB)

    X.H. Wang; J. Wiseman; D.J. Sung; D. McLean; William Peters; Jim Mullins; John Hugh; G. Evans; Vince Hamilton; Kenneth Robinette; Tim Krim; Michael Fleet

    1999-08-01

    Dewatering of ultra-fine (minus 150 {micro}m) coal slurry to less than 20% moisture is difficult using the conventional dewatering techniques. The main objective of the project was to evaluate a novel surface modification technique, which utilizes the synergistic effect of metal ions and surfactants in combination for the dewatering of ultra-fine clean-coal slurries using various dewatering techniques on a proof-of-concept (POC) scale of 0.5 to 2 tons per hour. The addition of conventional reagents and the application of coal surface modification technique were evaluated using vacuum filtration, hyperbaric (pressure) filtration, ceramic plate filtration and screen-bowl centrifuge techniques. The laboratory and pilot-scale dewatering studies were conducted using the fine-size, clean-coal slurry produced in the column flotation circuit at the Powell Mountain Coal Company, St. Charles, VA. The pilot-scale studies were conducted at the Mayflower preparation plant in St. Charles, VA. The program consisted of nine tasks, namely, Task 1--Project Work Planning, Task 2--Laboratory Testing, Task 3--Engineering Design, Task 4--Procurement and Fabrication, Task 5--Installation and Shakedown, Task 6--System Operation, Task 7--Process Evaluation, Task 8--Equipment Removal, and Task 9--Reporting.

  11. FPGA Techniques Based New Hybrid Modulation Strategies for Voltage Source Inverters

    OpenAIRE

    Sudha, L. U.; J. Baskaran; Elankurisil, S. A.

    2015-01-01

    This paper corroborates three different hybrid modulation strategies suitable for single-phase voltage source inverter. The proposed method is formulated using fundamental switching and carrier based pulse width modulation methods. The main tale of this proposed method is to optimize a specific performance criterion, such as minimization of the total harmonic distortion (THD), lower order harmonics, switching losses, and heat losses. The proposed method is articulated using fundamental switch...

  12. Cost-effectiveness of HIV testing referral strategies among tuberculosis patients in India.

    Directory of Open Access Journals (Sweden)

    Lauren M Uhler

    Full Text Available BACKGROUND: Indian guidelines recommend routine referral for HIV testing of all tuberculosis (TB patients in the nine states with the highest HIV prevalence, and selective referral for testing elsewhere. We assessed the clinical impact and cost-effectiveness of alternative HIV testing referral strategies among TB patients in India. METHODS AND FINDINGS: We utilized a computer model of HIV and TB disease to project outcomes for patients with active TB in India. We compared life expectancy, cost, and cost-effectiveness for three HIV testing referral strategies: 1 selective referral for HIV testing of those with increased HIV risk, 2 routine referral of patients in the nine highest HIV prevalence states with selective referral elsewhere (current standard, and 3 routine referral of all patients for HIV testing. TB-related data were from the World Health Organization. HIV prevalence among TB patients was 9.0% in the highest prevalence states, 2.9% in the other states, and 4.9% overall. The selective referral strategy, beginning from age 33.50 years, had a projected discounted life expectancy of 16.88 years and a mean lifetime HIV/TB treatment cost of US$100. The current standard increased mean life expectancy to 16.90 years with additional per-person cost of US$10; the incremental cost-effectiveness ratio was US$650/year of life saved (YLS compared to selective referral. Routine referral of all patients for HIV testing increased life expectancy to 16.91 years, with an incremental cost-effectiveness ratio of US$730/YLS compared to the current standard. For HIV-infected patients cured of TB, receiving antiretroviral therapy increased survival from 4.71 to 13.87 years. Results were most sensitive to the HIV prevalence and the cost of second-line antiretroviral therapy. CONCLUSIONS: Referral of all patients with active TB in India for HIV testing will be both effective and cost-effective. While effective implementation of this strategy would require

  13. CONTROL TECHNIQUES FOR VARIOUS BIPOLAR PWM STRATEGIES OF THREE PHASE FIVE LEVEL CASCADED INVERTER

    Directory of Open Access Journals (Sweden)

    C. R. BALAMURUGAN

    2015-07-01

    Full Text Available This paper presents different types of bipolar Pulse Width Modulation (PWM strategies for the chosen Cascaded MultiLevel Inverter (CMLI. The main purpose of MLI is to use power semiconductor devices of lower voltage ratings to realize high voltage levels at inverter output. Due to their ability to obtain refined output voltage waveforms, reduced Total Harmonic Distortion (THD and reduced EMI problems by reducing the switching dv/dt. In this paper, a three phase CMLI is controlled with Sinusoidal PWM strategy with Phase Disposition PWM (PDPWM, Phase Opposition and Disposition PWM (PODPWM, Alternative Phase Opposition and Disposition PWM (APODPWM, Phase Shift PWM (PSPWM and hybrid modulation strategy and the variation of THD in their outputs are observed by varying the modulation index. Simulations are performed using MATLAB-SIMULINK. It is observed that APODPWM and PSPWM provide output with relatively low distortion. It is also seen that PS, APOD and hybrid PWM are found to perform better since they provide relatively higher fundamental RMS output voltage. From hardware results it is seen that POD PWM provides output with relatively low distortion. It is also observed that PSPWM is found to perform better since it provide relatively higher fundamental RMS output voltage.

  14. A new strategy for the synthesis of iron-oxide nanocrystals by using a single-spinneret electrospinning technique.

    Science.gov (United States)

    Xu, Guo-Rong; Wang, Jiao-Na; Li, Cong-Ju

    2013-10-01

    Iron-oxide nanocrystals (IONCs) have been widely researched, owing to their unique physical and chemical properties. Herein, a new strategy that involves an electrospinning technique with the addition of a surfactant is reported as an effective method for the fabrication of shaped IONCs. With the same precursor compositions, only iron-oxide nanoparticles were obtained by using a sol-gel method without electrospinning. However, when the electrospinning technique was introduced, IONCs with special geometrical shapes (e.g., octahedral) were obtained. Characterization data indicated that the IONCs were composed of magnetite (Fe3O4) and maghemite (γ-Fe2O3), the ratio of which could be tuned by changing the concentration of the surfactants in the precursor solutions. A mechanism for the formation of IONCs is also proposed. The effect of surfactant on the decomposition of the iron complex is the main motivation for the formation of IONCs. In the sol-gel method without electrospinning, this effect is completely inhibited by the disturbance of long molecular chains. However, in the electrospinning strategy, such disturbance can be completely or partially diminished by the electrical force field during the electrospinning process and by the spatial effect of the nanofibers, thus leading to the formation of IONCs. Finally, the magnetic properties of the obtained IONCs were investigated. This strategy is versatile and environmentally friendly and it will be applicable to the synthesis of many other functional inorganic materials.

  15. The Exploitive Mating Strategy of the Dark Triad Traits: Tests of Rape-Enabling Attitudes.

    Science.gov (United States)

    Jonason, Peter K; Girgis, Mary; Milne-Home, Josephine

    2017-01-24

    The Dark Triad traits have been repeatedly labeled as facilitating an exploitive mating strategy. However, various researchers have repeatedly conflated short-term mating or casual sex with an exploitive mating strategy. In this study using Mechanical Turk participants (N = 252; 142 men, 110 women), we provided a better test of just how sexually exploitive those high on the Dark Triad traits might be by examining how the traits related to rape-enabling attitudes. We examined how each trait may facilitate rape, whether these associations were robust to partialing the variance associated with the Big Five traits and similar in men and women, and showed that one reason why men may be more likely to rape than women is they are characterized by the Dark Triad traits more than women are. In so doing, we test the confluence model of rape that asserts that personality traits similar to the Dark Triad traits act as one pathway to rape.

  16. Balancing Instructional Techniques and Delivery Formats in Capstone Business Strategy Courses

    Science.gov (United States)

    Alstete, Jeffrey W.; Beutell, Nicholas J.

    2016-01-01

    Purpose: The purpose of this paper is to contend that collegiate programs should carefully plan their capstone courses in light of the educational mission, pedagogical content knowledge, instructional techniques and delivery formats. Design/methodology/approach: This is a concept paper with elements of theory building from the case of business…

  17. Synthesis of robust feedback missile control strategies by using LMI techniques

    NARCIS (Netherlands)

    Trottemant, E.J.; Weiss, M.; Vermeulen, A.

    2009-01-01

    Robust programming, and more specific LMI techniques, have proven to be an extremely effective tool for the synthesis of missile guidance laws. The advantage of this model-based approach is that a large class of uncertainties can be taken into account and a robust guidance law is obtained. In this p

  18. Concepts and strategies of organic plant breeding in light of novel breeding techniques

    NARCIS (Netherlands)

    Nuijten, Edwin; Messmer, Monika M.; Lammerts van Bueren, Edith

    2017-01-01

    In this paper, we describe the development of a set of guiding principles for the evaluation of breeding techniques by the organic sector over time. The worldwide standards of organic agriculture (OA) do not allow genetic engineering (GE) or any products derived from genetic engineering. The

  19. The Delphi Technique: A Research Strategy for Career and Technical Education

    Science.gov (United States)

    Stitt-Gohdes, Wanda L.; Crews, Tena B.

    2004-01-01

    Career and technical education research often centers around quantitative research designs. The Delphi Technique provides a structured communication process designed to produce a detailed examination of a topic and/or problem and discussion from the participating group. The contributions of individuals via this tool produce a group perspective not…

  20. MBB strategy consideration: From microsystem technique to the space transportation system SAENGER 2

    Science.gov (United States)

    Vogels, Hanns Arnt

    Microsystems technique, as an example of technology developments, and the future space transportation system SAENGER 2 are treated. Microelectronics, micromechanics, and microoptics are presented. The characteristics of the materials used in microsystems technology are discussed. Economic and nonpolluting solar energy systems for future space systems are discussed. The status and the future of hypersonic transportation systems are discussed.

  1. New Strategies for Powder Compaction in Powder-based Rapid Prototyping Techniques

    NARCIS (Netherlands)

    Budding, A.; Vaneker, Thomas H.J.

    2013-01-01

    In powder-based rapid prototyping techniques, powder compaction is used to create thin layers of fine powder that are locally bonded. By stacking these layers of locally bonded material, an object is made. The compaction of thin layers of powder mater ials is of interest for a wide range of

  2. Relation of Elite Rifle Shooters' Technique-Test Measures to Competition Performance.

    Science.gov (United States)

    Ihalainen, Simo; Linnamo, Vesa; Mononen, Kaisu; Kuitunen, Sami

    2016-07-01

    To describe the long-term changes in shooting technique in relation to competition performances in elite air-rifle shooters. Seventeen elite shooters completed simulated air-rifle shooting-competition series in 3 consecutive seasons, participating on 15 ± 7 testing occasions. Shooting score and aiming-point-trajectory variables were obtained with an optoelectronic shooting device, and postural-balance variables were measured with force platform. Shooters' competition results were collected from all international and national competitions during the 3-y period. Mean test score, stability of hold, aiming accuracy, cleanness of triggering, and postural balance improved during the 3-y period (ANOVA, time, P < .05-.01). Seasonal mean test results in stability of hold (R = -.70, P = .000) and cleanness of triggering (R = -.75, P = .000) were related to competition performances. Changes in stability of hold (R = -.61, P = .000) and cleanness of triggering (R = -.39, P = .022) were also related to the changes in competition performances. Postural balance in shooting direction was more related to cleanness of triggering (R = .57, P = .000), whereas balance in cross-shooting direction was more related to stability of hold (R = .70, P = .000). The shooting-technique testing used in the current study seems to be a valid and useful tool for long-term performance assessment. Stability of hold, cleanness of triggering, and postural balance can be further developed even at the elite level, resulting in improved competition performances.

  3. Negative Expiratory Pressure Technique: An Awake Test to Measure Upper Airway Collapsibility in Adolescents

    Science.gov (United States)

    Carrera, Helena Larramona; Marcus, Carole L.; McDonough, Joseph M.; Morera, Joan C. Oliva; Huang, Jingtao; Farre, Ramon; Montserrat, Josep M.

    2015-01-01

    Study Objectives: Upper airway (UA) collapsibility is a major pathophysiologic feature of the obstructive sleep apnea syndrome (OSAS). In adolescents, it is measured by obtaining the slope of pressure-flow relationship (SPF) while applying negative nasal pressure during sleep. An easier technique to assess UA collapsibility, consisting of application of negative expiratory pressure (NEP) during wakefulness, has demonstrated differences between control and OSAS subjects. We hypothesized that the NEP technique would correlate with SPF as a measurement of UA collapsibility in adolescents. Design: During wakefulness, NEP of −5 cm H2O in the seated and supine position was applied during the first second of expiration. The area under the expiratory flow-volume curve during NEP was compared to tidal breathing (RatioNEP). In addition, adolescents underwent SPF measurements during sleep. Two SPF techniques were performed to measure the activated and relatively hypotonic UA. Setting: Pediatric sleep laboratory. Participants: Seven adolescents with OSAS and 20 controls. Results: In the seated position, there was a correlation between RatioNEP and both hypotonic SPF (r = −0.39, P = 0.04) and activated SPF (r = −0.62, P = 0.001). In the supine position, there was a correlation between RatioNEP and activated SPF (r = −0.43, P = 0.03) and a trend for hypotonic SPF (r = −0.38, P = 0.06). Conclusions: The negative expiratory pressure (NEP) technique correlates with the hypotonic and activated slope of pressure-flow relationship measurements. The seated position showed the strongest correlation. The NEP technique can be used as an alternative method to evaluate upper airway collapsibility in adolescents. Citation: Carrera HL, Marcus CL, McDonough JM, Morera JC, Huang J, Farre R, Montserrat JM. Negative expiratory pressure technique: an awake test to measure upper airway collapsibility in adolescents. SLEEP 2015;38(11):1783–1791. PMID:26158888

  4. Modernization of Physical Appearance and Solution Color Tests Using Quantitative Tristimulus Colorimetry: Advantages, Harmonization, and Validation Strategies.

    Science.gov (United States)

    Pack, Brian W; Montgomery, Laura L; Hetrick, Evan M

    2015-10-01

    Color measurements, including physical appearance, are important yet often misunderstood and underappreciated aspects of a control strategy for drug substances and drug products. From a patient safety perspective, color can be an important control point for detecting contamination, impurities, and degradation products, with human visual acuity often more sensitive for colored impurities than instrumental techniques such as HPLC. Physical appearance tests and solution color tests can also serve an important role in ensuring that appropriate steps are taken such that clinical trials do not become unblinded when the active material is compared with another product or a placebo. Despite the importance of color tests, compendial visual tests are not harmonized across the major pharmacopoeias, which results in ambiguous specifications of little value, difficult communication of true sample color, and significant extra work required for global registration. Some pharmacopoeias have not yet recognized or adopted technical advances in the instrumental measurement of color and appearance, whereas others begin to acknowledge the advantage of instrumental colorimetry, yet leave implementation of the technology ambiguous. This commentary will highlight the above-mentioned inconsistencies, provide an avenue toward harmonization and modernization, and outline a scientifically sound approach for implementing quantitative technologies for improved measurement, communication, and control of color and appearance for both solutions and solids. Importantly, this manuscript, for the first time, outlines a color method validation approach that is consistent with the International Conference on Harmonization's guidance on the topic of method validation.

  5. Cost and Efficacy Assessment of an Alternative Medication Compliance Urine Drug Testing Strategy.

    Science.gov (United States)

    Doyle, Kelly; Strathmann, Frederick G

    2017-02-01

    This study investigates the frequency at which quantitative results provide additional clinical benefit compared to qualitative results alone. A comparison between alternative urine drug screens and conventional screens including the assessment of cost-to-payer differences, accuracy of prescription compliance or polypharmacy/substance abuse was also included. In a reference laboratory evaluation of urine specimens from across the United States, 213 urine specimens with provided prescription medication information (302 prescriptions) were analyzed by two testing algorithms: 1) conventional immunoassay screen with subsequent reflexive testing of positive results by quantitative mass spectrometry; and 2) a combined immunoassay/qualitative mass-spectrometry screen that substantially reduced the need for subsequent testing. The qualitative screen was superior to immunoassay with reflex to mass spectrometry in confirming compliance per prescription (226/302 vs 205/302), and identifying non-prescription abuse (97 vs 71). Pharmaceutical impurities and inconsistent drug metabolite patterns were detected in only 3.8% of specimens, suggesting that quantitative results have limited benefit. The percentage difference between the conventional testing algorithm and the alternative screen was projected to be 55%, and a 2-year evaluation of test utilization as a measure of test order volume follows an exponential trend for alternative screen test orders over conventional immunoassay screens that require subsequent confirmation testing. Alternative, qualitative urine drug screens provide a less expensive, faster, and more comprehensive evaluation of patient medication compliance and drug abuse. The vast majority of results were interpretable with qualitative results alone indicating a reduced need to automatically reflex to quantitation or provide quantitation for the majority of patients. This strategy highlights a successful approach using an alternative strategy for both the

  6. Novel Engineering and Fabrication Techniques Tested in Low-Noise- Research Fan Blades

    Science.gov (United States)

    Cunningham, Cameron C.

    2003-01-01

    A major source of fan noise in commercial turbofan engines is the interaction of the wake from the fan blades with the stationary vanes (stators) directly behind them. The Trailing Edge Blowing (TEB) project team at the NASA Glenn Research Center designed and fabricated new fan blades to study the effects of fan trailing edge blowing as a potential noise-reduction concept. The intent is to fill the rotor wake by supplying air to the rotor blade trailing edge at the proper conditions to minimize the wake deficit, and thus generate less noise. The TEB hardware is designed for the Active Noise Control Fan (ANCF) test rig in Glenn's Aeroacoustic Propulsion Laboratory. For this test, the air is fed from an external supply through the shaft of the rig. It is distributed to the base of each blade through an impeller, where it is forced into a plenum at the core of each blade. In actual engine configuration, air would most likely be bled from the compressor, but only at times when noise is an issue, such as takeoffs and landings. Glenn researchers designed and manufactured the blades in-house, using new techniques and concepts. The skins, which were designed for maximum strength in the directions of highest stress, were molded from multiple layers of carbon fiber. Considerable use was made of rapid prototyping techniques, such as laser sintering. The core was sintered from a lightweight polymer, and the retainer was CNC-machined (computer numerical control machined) from aluminum. All the components were joined with a cold-cure aerospace adhesive. These techniques and processes reduced the overall cost and allowed the new concept to be studied much sooner than would be possible using traditional fabrication methods. Since this test rig did not support the use of blade-monitoring techniques such as strain gauges, extensive bench testing was required to qualify the design. The blades were examined using a variety of methods including holography, pull tests (cyclic and

  7. TESTING THE PERFORMANCE OF DIFFERENT SPATIAL INTERPOLATION TECHNIQUES ON MAPPING SHORT DATASERIES OF PRECIPITATION PROPRETIES

    Directory of Open Access Journals (Sweden)

    COJOCARU ŞTEFANA

    2014-03-01

    Full Text Available patial interpolation, in the context of spatial analysis, can be defined as the derivation of new data from already known information, a technique frequently used to predict and quantify spatial variation of a certain property or parameter. In this study we compared the performance of Inverse Distance Weighted (IDW, Ordinary Kriging and Natural Neighbor techniques, applied in spatial interpolation of precipitation parameters (pH, electrical conductivity and total dissolved solids. These techniques are often used when the area of interest is relatively small and the sampled locations are regularly spaced. The methods were tested on data collected in Iasi city (Romania between March – May 2013. Spatial modeling was performed on a small dataset, consisting of 7 sample locations and 13 different known values of each analyzed parameter. The precision of the techniques used is directly dependent on sample density as well as data variation, greater fluctuations in values between locations causing a decrease in the accuracy of the methods used. To validate the results and reveal the best method of interpolating rainfall characteristics, leave-one – out cross-validation approach was used. Comparing residues between the known values and the estimated values of pH, electrical conductivity and total dissolved solids, it was revealed that Natural Neighbor stands out as generating the smallest residues for pH and electrical conductivity, whereas IDW presents the smallest error in interpolating total dissolved solids (the parameter with the highest fluctuations in value.

  8. Environmental Hazard Identification Technique Developing of Territorial Administrations Strategy as Exemplified in Siberian Federal District

    Science.gov (United States)

    Timofeeva, S. S.; Garmishev, V. V.; Lugovtsova, N. Yu

    2016-04-01

    This work, on the example of the Siberian Federal District of the Russian Federation, presents a method for determining mass airbursts of combustion gaseous eco-toxicants, as a technique for assessing the contributory environmental load on the atmosphere. Potential environmental hazards are analyzed by mass of contaminated airbursts. A comparison of specific gross toxicants’ emissions in territorial entities of the Russian Federation is made.

  9. Management strategies for infected total hip arthroplasty. A critical appreciation of problems and techniques.

    Science.gov (United States)

    Karachalios, Theofilos; Koutalos, Antonios; Komnos, George

    2014-10-02

    Infection is a devastating complication of total hip arthroplasty (THA). Risk factors have been recognised and prevention is possible. The nature of the disease is heterogeneous and for satisfactory management one has to weigh factors related to pathogen, host, local soft tissue, bone stock, surgeon experience and financial resources. Available data in the current literature is of poor quality and there is a lack of data comparing different techniques. Referral of patients to dedicated departments with the appropriate facilities may be more appropriate.

  10. Language Learner Strategies and Linguistic Competence as Factors Affecting Achievement Test Scores in English for Specific Purposes

    Science.gov (United States)

    Jurkovic, Violeta

    2010-01-01

    The article examines the effect of two factors on achievement test scores in English as a foreign language for specific purposes in higher education: preexisting linguistic competence and frequency of use of language learner strategies. The rationale for the analysis of language learner strategies as a factor affecting achievement test outcomes is…

  11. Guided wave technique for non-destructive testing of StifPipe

    Science.gov (United States)

    Amjad, Umar; Yadav, Susheel K.; Nguyen, Chi H.; Ehsani, Mohammad; Kundu, Tribikram

    2015-03-01

    The newly-developed StifPipe® is an effective technology for repair and strengthening of existing pipes and culverts. The wall of this pipe consists of a lightweight honeycomb core with carbon or glass fiber reinforced polymer (FRP) applied to the skin. The presence of the hollow honeycomb introduces challenges in the nondestructive testing (NDT) of this pipe. In this study, it is investigated if guided waves, excited by PZT (Lead ZirconateTitanate) transducer can detect damages in the honeycomb layer of the StifPipe®. Multiple signal processing techniques are used for in-depth study and understanding of the recorded signals. The experimental technique for damage detection in StifPipe® material is described and the obtained results are presented in this paper.

  12. Design of a reliable and self-testing VLSI datapath using residue coding techniques

    Science.gov (United States)

    Sayers, I. L.; Kinniment, D. J.; Chester, E. G.

    1986-05-01

    The application of a residue code to check the data-path of a CPU is discussed. The structure of the data-path and the instruction set that it can perform are described, including the data-path registers, ALU, and control. The use of a mode 3 residue code to check the data-path is described in detail, giving logic diagrams and circuit layouts. The results are compared to those that might be obtained using Scan Path or BILBO techniques. The use of the residue code provides fault tolerance in a VLSI design at a small cost compared to triple modular redundancy and duplication techniques. A detailed evaluation of the increase in chip area required to produce a self-testing chip is also given.

  13. Use of molecular marker techniques in seed testing by Brazilian seed companies

    Directory of Open Access Journals (Sweden)

    Della Vecchia P.T.

    1998-01-01

    Full Text Available Seed market is becoming global and globalization is growing very fast. To compete favourably in this new global seed world, quality and cost are and will be certanly the key issues. High seed quality can only be obtained by a thorough control of the entire seed production process, step by step from planning to final delivery. That requires science, technology, expertise, experience, good management and certanly, the most important, an absolute and unconditional commitment with quality. Seed testing for quality assurance is one important step in the process of production of high quality seed. In the late years a considerable amount of research has been published, particularly on the use of some Polymerase Chain Reaction DNA based new technologies (RAPD, microsatelites, AFLP for genetic purity determinations in seed testing. As far as we know, no Brazilian seed company is using, on regular basis, RAPD or other molecular marker techniques in the determination of genetic purity in seed testing. Most of these are using morphological or physiological traits expressed by seed, seedling or mature plant and/or electrophoresis of seed or seedling proteins/isoenzymes for that purpose. Main reasons for that are: DNA molecular marker techniques are relatively new; lack of specialized personnel to run DNA molecular marker assays on routine basis; higher cost/sample when compared to proteins/isoenzymes electrophoresis.

  14. Novel Infrared Coherent Sources and Techniques for Spectroscopic Test of Fundamental Physics Principles

    Science.gov (United States)

    Pastor, P. Cancio; Galli, I.; Giusfredi, G.; Mazzotti, D.; De Natale, P.

    2013-06-01

    Recent achievements in high sensitivity and precision molecular spectroscopy in the mid-IR open new perspectives for experiments looking for possible violations of the basic postulates in quantum mechanics or quantum electro-dynamics in simple molecular systems. A new generation of hybrid infrared sources, including a direct link to optical frequency comb synthesizers (OFCSs) is under development. They provide metrological frequency precision and sensitivities that have achieved record levels of tens of parts-per-quadrillion when appropriate spectroscopic techniques are implemented. Such very recent developments will be reviewed. An example of possible application to the test of fundamental principles is attacking the symmetrization postulate (SP). Actually, the requirement of symmetry of the wave function under exchange of identical particles has a striking demonstration in the spectra of molecules including identical nuclei. The basic idea of the spectroscopic tests is to search with extremely high sensitivity for (weak) molecular lines involving the forbidden states. Since the early test of SP violation in bosonic particles, ^{12}C^{16}O_2 molecule has been considered a playground system. An upper limit of 10^{-11} to such violation was measured more than one decade ago by our group. The recent developed spectroscopic technique^{d,e} measured a minimum detected CO_2 gas pressures, in a 1-Hz bandwidth, of a few tens of femtobar, which could improve the previous test by more than two orders of magnitude. Progress in high sensitivity spectroscopic measurements in view of new violation tests will be reviewed, to investigate molecules with two and also three identical nuclei, like SO_3 and NH_3. I. Galli et al., Opt. Lett. 35, 3616 (2010). I. Ricciardi et al., Opt. Express 20, 9178 (2012). S. Borri, et al., Opt. Lett. 37, 1011 (2012). G. Giusfredi et al., Phys. Rev. Lett. 104, 110801(2010). I. Galli et al., Phys. Rev. Lett. 107, 270802 (2011). D. Mazzotti et al

  15. Nondestructive Testing Techniques for Quality Detection of Meats%肉品品质的无损检测方法

    Institute of Scientific and Technical Information of China (English)

    孔宪琴

    2009-01-01

    At present, some foreign researchers of meat industry developed countries are studying and applying nondestructive testing techniques to detect meat quality. In our country, these techniques are seldom used besides some techniques using electromagnetic properties. This paper introduces some modern nondestructive testing techniques for quality detection of meat, such as Supersonic wave,electronic Nose, electromagnetic method, near infrared, Raman Spectroscopy and computer vision technology. These techniques can meet the requirements of high speed and high accuracy on line detection of meat. Besides, further research and possible applications are also discussed.

  16. Opportunities for an alternative integrating testing strategy for carcinogen hazard assessment?

    Science.gov (United States)

    Doktorova, Tatyana Y; Pauwels, Marleen; Vinken, Mathieu; Vanhaecke, Tamara; Rogiers, Vera

    2012-02-01

    The 2-year rodent carcinogenicity bioassay evolved more than 40 years ago, and although it is complex, long lasting, expensive, and animal consuming, it is still the only generally accepted test for assessing the carcinogenicity of chemicals. Over time, different alternative approaches have been developed with the final goal to replace the bioassay. Unfortunately, at present, none of these strategies alone provides sufficient assurance of accurate prediction. In this review paper, we discuss the major advantages and pitfalls of the existing alternative methodologies to the carcinogenicity bioassay. Finally, based on the available scientific data in the public domain, we propose what we would like to call a "feasible integrated testing strategy" which incorporates some promising alternatives, providing at the same time information on the mechanism of action and the toxic nature of the compounds tested. It is, however, clear that the adoption of whatever "new" testing scheme should be considered with caution and its effectiveness should be experimentally demonstrated in advance by addressing a reasonable number of chemical carcinogens and non-carcinogens from a variety of structural and functional classes.

  17. [High time for wide application of an opting-out strategy for HIV testing].

    Science.gov (United States)

    Dukers-Muijrers, N H T; Dukers-Muijrers, H T M; Heijman, R L J; van Leent, E J M; Coutinho, R A; Thiesbrummel, H F J; Fennema, J S A

    2007-12-01

    --Despite the current active HIV test policy, the effects of the former policy are still visible, i.e. a relatively low number of individuals that have ever been tested for HIV. --The number of HIV tests and knowledge of current HIV status has increased among visitors to the STI clinic in Amsterdam. --Nevertheless, anonymous HIV surveillance among visitors to the STI clinic shows that a considerable proportion of HIV-infected individuals (24% of men who have sex with men (MSM) and 80% of heterosexuals) are unaware of the infection. --A new opting-out strategy for HIV testing in STI clinics is recommended. --The opting-out strategy may also be applicable to other medical settings, especially those that treat target populations such as MSM, heterosexuals with STI-related symptoms, and persons originating from AIDS-endemic regions. --The opting-out system was initiated in the Amsterdam STI clinic in 2007 in order to further reduce the number of undiagnosed HIV infections.

  18. Odor sampling: techniques and strategies for the estimation of odor emission rates from different source types.

    Science.gov (United States)

    Capelli, Laura; Sironi, Selena; Del Rosso, Renato

    2013-01-15

    Sampling is one of the main issues pertaining to odor characterization and measurement. The aim of sampling is to obtain representative information on the typical characteristics of an odor source by means of the collection of a suitable volume fraction of the effluent. The most important information about an emission source for odor impact assessment is the so-called Odor Emission Rate (OER), which represents the quantity of odor emitted per unit of time, and is expressed in odor units per second (ou∙s-1). This paper reviews the different odor sampling strategies adopted depending on source type. The review includes an overview of odor sampling regulations and a detailed discussion of the equipment to be used as well as the mathematical considerations to be applied to obtain the OER in relation to the sampled source typology.

  19. "Enzyme Test Bench," a high-throughput enzyme characterization technique including the long-term stability.

    Science.gov (United States)

    Rachinskiy, Kirill; Schultze, Hergen; Boy, Matthias; Bornscheuer, Uwe; Büchs, Jochen

    2009-06-01

    A new high throughput technique for enzyme characterization with specific attention to the long term stability, called "Enzyme Test Bench," is presented. The concept of the Enzyme Test Bench consists of short term enzyme tests in 96-well microtiter plates under partly extreme conditions to predict the enzyme long term stability under moderate conditions. The technique is based on the mathematical modeling of temperature dependent enzyme activation and deactivation. Adapting the temperature profiles in sequential experiments by optimal non-linear experimental design, the long term deactivation effects can be purposefully accelerated and detected within hours. During the experiment the enzyme activity is measured online to estimate the model parameters from the obtained data. Thus, the enzyme activity and long term stability can be calculated as a function of temperature. The engineered instrumentation provides for simultaneous automated assaying by fluorescent measurements, mixing and homogenous temperature control in the range of 10-85 +/- 0.5 degrees C. A universal fluorescent assay for online acquisition of ester hydrolysis reactions by pH-shift is developed and established. The developed instrumentation and assay are applied to characterize two esterases. The results of the characterization, carried out in microtiter plates applying short term experiments of hours, are in good agreement with the results of long term experiments at different temperatures in 1 L stirred tank reactors of a week. Thus, the new technique allows for both: the enzyme screening with regard to the long term stability and the choice of the optimal process temperature regarding such process parameters as turn over number, space time yield or optimal process duration. The comparison of the temperature dependent behavior of both characterized enzymes clearly demonstrates that the frequently applied estimation of long term stability at moderate temperatures by simple activity measurements

  20. Comparison of NDT techniques to evaluate CFRP. Results obtained in a MAIzfp round robin test

    Energy Technology Data Exchange (ETDEWEB)

    Grosse, Christian U. [Technische Univ. Muenchen (Germany). Chair of Non-destructive Testing; Goldammer, Matthias; Grager, Jan-Carl [Siemens AG Corporate Technology, Muenchen (Germany); and others

    2016-10-01

    Fiber reinforced polymeric materials are used for lightweight constructions and are an integral part of cars, airplanes or rotor blades of wind turbines. Nondestructive testing (NDT) methods play an increasing role concerning the manufacturing process and the inspection during lifetime. The selection of the best NDT technique for a certain application depends - of course - on many factors including the type, position and size of the defect to be detected but also on secondary issues like accessibility, automation, testing costs, reliability and resolution to mention only some. For the more technical-scientific part of these issues, the determination of the probability of detection (PoD) plays a significant role. Early in the design process questions should be raised concerning the probability with which certain attribute of interest (a defect that has an effect on the structural behavior) can be detected (and localized) in a certain construction. Several defect types have been identified to be critical like impact damages, undulations and porosity. Test samples out of differently processed Carbon Fiber-Reinforced Polymers (CFRP) as used in the automotive or aeronautical industry have been produced including defects of different type and size. In order to determine the PoD and to check whether a technique is applicable the different partners applied a broad variety of selected NDT techniques including Micro CT, Ultrasound (including phased-array and air-coupled UT), Active Thermography, Eddy Current, Vibration and Visual Analysis and Local Acoustic Resonance Spectroscopy (LARS). The presentation will summarize some of the results of the experiments and ongoing data analysis.

  1. Characterization of hydroxypropylmethylcellulose films using microwave non-destructive testing technique.

    Science.gov (United States)

    Anuar, Nor Khaizan; Wui, Wong Tin; Ghodgaonkar, Deepak K; Taib, Mohd Nasir

    2007-01-17

    The applicability of microwave non-destructive testing (NDT) technique in characterization of matrix property of pharmaceutical films was investigated. Hydroxypropylmethylcellulose and loratadine were selected as model matrix polymer and drug, respectively. Both blank and drug loaded hydroxypropylmethylcellulose films were prepared using the solvent-evaporation method and were conditioned at the relative humidity of 25, 50 and 75% prior to physicochemical characterization using microwave NDT technique as well as ultraviolet spectrophotometry, differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FT-IR) techniques. The results indicated that blank hydroxypropylmethylcellulose film exhibited a greater propensity of polymer-polymer interaction at the O-H and C-H domains of the polymer chains upon conditioned at a lower level of relative humidity. In the case of loratadine loaded films, a greater propensity of polymer-polymer and/or drug-polymer interaction via the O-H moiety was mediated in samples conditioned at the lower level of relative humidity, and via the C-H moiety when 50% relative humidity was selected as the condition for sample storage. Apparently, the absorption and transmission characteristics of both blank and drug loaded films for microwave varied with the state of polymer-polymer and/or drug-polymer interaction involving the O-H and C-H moieties. The measurement of microwave NDT test at 8GHz was sensitive to the chemical environment involving O-H moiety while it was greatly governed by the C-H moiety in test conducted at a higher frequency band of microwave. Similar observation was obtained with respect to the profiles of microwave NDT measurements against the state of polymer-polymer and/or drug-polymer interaction of hydroxypropylmethylcellulose films containing chlorpheniramine maleate. The microwave NDT measurement is potentially suitable for use as an apparent indicator of the state of polymer-polymer and drug

  2. Field dependence and verbalized strategies on the portable rod-and-frame test by depressed outpatients and normal controls.

    Science.gov (United States)

    Calamari, E; Pini, M; Puleggio, A

    2000-12-01

    This study examined the relationships between scores on the cognitive style of field dependence-independence and verbalized strategies on the Portable Rod-and-Frame Test for normal and psychopathological outpatients. We attempted to verify (a) Manning's hypothesis (1991) of a correspondence between scores on field dependence and external strategies (reference to the visual field) and scores on field independence and internal strategies (reference to the body) on perceptual tasks, and (b) a tendency of depressed persons to score as field dependent, and (c) use of external verbalized strategies. A total of 50 depressed outpatients and 50 normal controls were administered the test and requested to report the strategy they had employed to solve the problem. Contrary to Manning's findings, no significant relationship was found between cognitive style and verbalized strategies in the total sample. Depressed outpatients classified as internal scored significantly higher on the Group Embedded Figures Test but appeared more field dependent on the Rod-and-Frame Test. Moreover, only for the former test did depressed outpatients score more field-dependent than controls. Finally, no significant relationship was found between the diagnosis of depression and use of external strategies; however, field dependence and the use of external strategies on the Rod-and-Frame Test were associated with more severe depressive symptoms measured by the D scale of the MMPI-2. Further research is needed to assess the role of premorbid personality structures of depression in subjective and objective aspects of Rod-and-Frame Test performance.

  3. Nuclear Technology. Course 32: Nondestructive Examination (NDE) Techniques II. Module 32-4, Operation of Magnetic Particle Test Equipment.

    Science.gov (United States)

    Groseclose, Richard

    This fourth in a series of six modules for a course titled Nondestructive Examination (NDE) Techniques II describes the specific technique variables and options which are available to the test technician, provides instructions for selecting and operating the appropriate test equipment, describes physical criteria for detectable discontinuities,…

  4. Test Technique Development on the Irradiated Reconstituted PCVN Specimen in Hot Cell

    Energy Technology Data Exchange (ETDEWEB)

    Ahn, Sangbok; Oh, Wanho; Choo, Yongsun; Kim, Minchul; Lee, Bongsang [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    2006-07-01

    The degradation of fracture toughness is the important factor to restrict the life of nuclear pressure vessel in PWR reactors. A pressure vessel is operated in conformity with the fracture analysis based on ASME codes to ensure safety margins from the unstable fracture. A fracture analysis is performed based on the result from the Charpy impact tests in PWR reactor, but it has the questions to be exact solutions because the test results give indirect and excessively conservative values. Therefore the research to find an exact toughness parameter is undergoing to use the pre-cracked Charpy v-notch (PCVN). As results the master curve method is proposed in ASTM E1921 to be supposed an appropriate tool to evaluate the fracture toughness for the irradiated, or the operated pressure vessel materials. The surveillance test program to evaluate toughness degradation on existing commercial PWR reactor is performed through the impact test on Charpy specimens. It gives the lack of the specimen to evaluate the safety in toughness for on-going operation beyond design life. To overcome the shortage of specimen, the test method to use a reconstituted PCVN specimen fabricated from the broken half of Charpy specimen is proposed and adopted in foreign reactors. In this paper techniques developed for the reconstituted specimen from the domestic commercial PWR reactor in hot cell are described.

  5. Design and Implementation of Prosthetic Arm using Gear Motor Control Technique with Appropriate Testing

    CERN Document Server

    Neogi, Biswarup; Ghosal, Soumya; Das, Achintya; Tibarewala, D N

    2011-01-01

    Any part of the human body replication procedure commences the prosthetic control science. This paper highlights the hardware design technique of a prosthetic arm with implementation of gear motor control aspect. The prosthetic control arm movement has been demonstrated in this paper applying processor programming and with the successful testing of the designed prosthetic model. The architectural design of the prosthetic arm here has been replaced by lighter material instead of heavy metal, as well as the traditional EMG (electro myographic) signal has been replaced by the muscle strain.

  6. Utilizing constructivism learning theory in collaborative testing as a creative strategy to promote essential nursing skills.

    Science.gov (United States)

    Duane, Barbara T; Satre, Maria E

    2014-01-01

    In nursing education, students participate in individual learner testing. This process follows the instructionist learning theory of a system model. However, in the practice of nursing, success depends upon collaboration with numerous people in different capacities, critical thinking, clinical reasoning, and the ability to communicate with others. Research has shown that collaborative testing, a constructivism learning activity and a form of collaborative learning, enhances students' abilities to master these areas. Collaborative testing is a clear, creative strategy which constructivists would say supports the socio-linguistic base of their learning theory. The test becomes an active implementation of peer-mediated learning where individual knowledge is enhanced through problem solving or defense of an individual position with the collaborative method. There is criticism for the testing method's potential of grade inflation and for students to receive grade benefits with little effort. After a review of various collaborative testing methods, this nursing faculty implemented a collaborative testing format that addresses both the positive and negative aspects of the process.

  7. Implementation of alternative test strategies for the safety assessment of engineered nanomaterials.

    Science.gov (United States)

    Nel, A E

    2013-12-01

    Nanotechnology introduces a new field that requires novel approaches and methods for hazard and risk assessment. For an appropriate scientific platform for safety assessment, nanoscale properties and functions of engineered nanomaterials (ENMs), including how the physicochemical properties of the materials relate to mechanisms of injury at the nano-bio interface, must be considered. Moreover, this rapidly advancing new field requires novel test strategies that allow multiple toxicants to be screened in robust, mechanism-based assays in which the bulk of the investigation can be carried out at the cellular and biomolecular level whilst maintaining limited animal use and is based on the contribution of toxicological pathways to the pathophysiology of disease. First, a predictive toxicological approach for the safety assessment of ENMs will be discussed against the background of a '21st-century vision' for using alternative test strategies (ATSs) to perform toxicological assessment of large numbers of untested chemicals, thereby reducing a backlog that could otherwise become a problem for nanotechnology. An ATS is defined here as an alternative to animal experiments or refinement/reduction alternative to traditional animal testing. Secondly, the approach of selecting pathways of toxicity to screen for the pulmonary hazard potential of carbon nanotubes and metal oxides will be discussed, as well as how to use these pathways to perform high-content or high-throughput testing and how the data can be used for hazard ranking, risk assessment, regulatory decision-making and 'safer-by-design' strategies. Finally, the utility and disadvantages of this predictive toxicological approach to ENM safety assessment, and how it can assist the 21st-century vision, will be addressed.

  8. A new treatment strategy for severe arthrofibrosis of the knee. Surgical technique.

    Science.gov (United States)

    Wang, Jian-Hua; Zhao, Jin-Zhong; He, Yao-Hua

    2007-03-01

    To reduce the morbidity of traditional quadricepsplasty for the treatment of severe arthrofibrosis of the knee, we instituted a treatment regimen consisting of an initial extra-articular mini-invasive quadricepsplasty and subsequent intra-articular arthroscopic lysis of adhesions during the same anesthesia session. The purpose of the present study was to determine the results of this technique. From 1998 to 2001, twenty-two patients with severely arthrofibrotic knees were managed with this operative technique. The mean age of the patients at the time of the operation was thirty-seven years. After a mean duration of follow-up of forty-four months (minimum, twenty-four months), all patients were evaluated according to the criteria of Judet and The Hospital for Special Surgery knee-rating system. The average maximum degree of flexion increased from 27 degrees preoperatively to 115 degrees at the time of the most recent follow-up (p < 0.001). According to the criteria of Judet, the result was excellent for sixteen knees, good for five, and fair for one. The average Hospital for Special Surgery knee score improved from 74 points preoperatively to 94 points at the time of the most recent follow-up (p < 0.001). A superficial wound infection occurred in one patient. Only one patient had a persistent 15 degrees extension lag. This mini-invasive operation for the severely arthrofibrotic knee can be used to increase the range of motion and enhance functional outcome.

  9. Micro push-pull tests under unsaturated conditions: A new technique to investigate rhizosphere processes

    Science.gov (United States)

    Knecht, Kajsa; Nowack, Bernd; Schroth, Martin Herbert; Schulin, Rainer

    2010-05-01

    The rhizosphere differs in many aspects from the bulk soil. The growth of roots or uptake of water by plants alters directly the physical properties of the rhizosphere. Root activities such as absorption, respiration or exudation can change many chemical properties in the rhizosphere. The aim of this study is to develop a new micro technique that allows studying rhizosphere processes at microscopic scale in-situ. Our goal is to combine the technique of micro-suction cups with that of push-pull tests, creating a miniaturized system that is applicable to study not only concentrations but also reactions and exudation rates in the rhizosphere under conditions as undisturbed as possible. Push-pull tests have been used extensively on a larger scale for the investigation of chemical, physical and biological pollutant transport and transformation processes in aquifers. In a push-pull test, a solution containing reactive and non-reactive tracers is injected into a porous medium. After a defined time the test-solution/soilwater mixture is then extracted back from the same location. At first, we developed and validated a micro push-pull test procedure that works under saturated conditions in sand-filled boxes. It was possible to inject about 250 µl solution and extract 850 µl solution at a low and constant injection/extraction rate. The data were analyzed and successfully modeled considering advection, dispersion and molecular diffusion. Tracer concentrations of the extracted solution could be very well predicted without using any adjustable parameters. Molecular diffusion was found to play a significant role in determining the shape of the extraction curve. In a subsequent experiment using this technique, it was possible to quantify the degradation rate of citrate injected into a water-saturated, sand-filled box inoculated with denitrifying bacteria. The new technique thus proved to be an adequate tool to observe local biodegradation processes in situ. Now, we are

  10. Test of on-line alkali detector based on surface ionisation technique

    Energy Technology Data Exchange (ETDEWEB)

    Wiktorsson, L.-P.A.; Sjoestroem, L.K. [Chemical Technology, Stockholm (Sweden). Dept. of Chemical Engineering and Technology

    1998-12-31

    The objective of this project is to test on-line alkali metal measuring equipment in a reducing atmosphere. The equipment is based on surface ionisation (SI) technique. The tests have taken place in reactors of varying sizes, from mg per batch to continuous feeding of kg/h, non-pressurised and pressurised. On-line alkali metal detector prototypes have been tested in real gases at atmospheric and elevated pressure. The primary parts of the detector prototypes are a platinum filament and an ion collector. The first prototype (A) of the surface ionisation detector was tested in a mg-scale pyrolysis reactor, a so-called Pyrojector, by introducing the coal sample with a `pelletizer`. The generated detector signal, a current in the pA to {mu}A range, was directly proportional to the sample weight. The second prototype (B) of the surface ionisation detector was tested in a very tarry gas flow, 20 g tar/Nm{sup 3}, at atmospheric pressure in a continuously fed g/min-scale biomass pyrolysis apparatus. The generated detector signal, a current in the {mu}A range, was measured by a picoammeter and sampled on a computer. The feedstocks were pine and birch and straw. A third prototype (D) of the surface ionisation detector was tested during pressurised gasification in a fluidised bed reactor. The feedstock was birch. The prototype detected alkali in the gas, though the temperature was only 773-793 K in the vicinity of the detector. The filament temperature control has to be further developed and tested. 1 ref., 19 figs., 6 tabs.

  11. Freeze-drying as a preserving preparation technique for in vitro testing of human skin.

    Science.gov (United States)

    Franzen, Lutz; Vidlářová, Lucie; Kostka, Karl-Heinz; Schaefer, Ulrich F; Windbergs, Maike

    2013-01-01

    In vitro testing of drugs with excised human skin is a valuable prerequisite for clinical studies. However, the analysis of excised human skin presents several obstacles. Ongoing drug diffusion, microbial growth and changes in hydration state influence the results of drug penetration studies. In this work, we evaluate freeze-drying as a preserving preparation method for skin samples to overcome these obstacles. We analyse excised human skin before and after freeze-drying and compare these results with human skin in vivo. Based on comprehensive thermal and spectroscopic analysis, we demonstrate comparability to in vivo conditions and exclude significant changes within the skin samples due to freeze-drying. Furthermore, we show that freeze-drying after skin incubation with drugs prevents growth of drug crystals on the skin surface due to drying effects. In conclusion, we introduce freeze-drying as a preserving preparation technique for in vitro testing of human skin.

  12. ADAPTATION OF CRACK GROWTH DETECTION TECHNIQUES TO US MATERIAL TEST REACTORS

    Energy Technology Data Exchange (ETDEWEB)

    A. Joseph Palmer; Sebastien P. Teysseyre; Kurt L. Davis; Gordon Kohse; Yakov Ostrovsky; David M. Carpenter; Joy L. Rempe

    2015-04-01

    A key component in evaluating the ability of Light Water Reactors to operate beyond 60 years is characterizing the degradation of materials exposed to radiation and various water chemistries. Of particular concern is the response of reactor materials to Irradiation Assisted Stress Corrosion Cracking (IASCC). Some test reactors outside the United States, such as the Halden Boiling Water Reactor (HBWR), have developed techniques to measure crack growth propagation during irradiation. The basic approach is to use a custom-designed compact loading mechanism to stress the specimen during irradiation, while the crack in the specimen is monitored in-situ using the Direct Current Potential Drop (DCPD) method. In 2012 the US Department of Energy commissioned the Idaho National Laboratory and the MIT Nuclear Reactor Laboratory (MIT NRL) to take the basic concepts developed at the HBWR and adapt them to a test rig capable of conducting in-pile IASCC tests in US Material Test Reactors. The first two and half years of the project consisted of designing and testing the loader mechanism, testing individual components of the in-pile rig and electronic support equipment, and autoclave testing of the rig design prior to insertion in the MIT Reactor. The load was applied to the specimen by means of a scissor like mechanism, actuated by a miniature metal bellows driven by pneumatic pressure and sized to fit within the small in-core irradiation volume. In addition to the loader design, technical challenges included developing robust connections to the specimen for the applied current and voltage measurements, appropriate ceramic insulating materials that can endure the LWR environment, dealing with the high electromagnetic noise environment of a reactor core at full power, and accommodating material property changes in the specimen, due primarily to fast neutron damage, which change the specimen resistance without additional crack growth. The project culminated with an in

  13. [Introducing marketing strategies and techniques into the field of voluntary blood donation, to meet the rise in blood demand].

    Science.gov (United States)

    Pesavento, S; Bégué, L

    2011-04-01

    Social marketing uses marketing principles and techniques to induce a target audience to voluntary accept, reject, change or abandon a behaviour for the benefit of individuals, groups, or society as a whole. Thus, individual or societal gain is the primary goal of social marketing. This kind of marketing is frequently used in the United States or in Canada in several fields such as healthcare, social work, or the environment. In 2008, we introduced these strategies and techniques in the field of blood donation in France. This article describes what has been achieved in the last three years and outlines the main steps in the social marketing planning process: analyzing the social marketing environment, defining target audiences and objectives, building and implementing strategies and action plans, evaluating and monitoring. On the way to self-sufficiency, while respecting donors, social marketing is additional to the work done by the blood collection staffs, communication teams, and volunteers. Social marketing is a complementary tool to the work done by the blood collection staff, communication teams and blood donation organizations and can help to meet the challenge of self-sufficiency while still allowing for the privacy and rights of donors.

  14. Local confidence limits for IMRT and VMAT techniques: a study based on TG119 test suite.

    Science.gov (United States)

    Thomas, M; Chandroth, M

    2014-03-01

    The aim of this study was to generate a local confidence limit (CL) for intensity modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) techniques used at Waikato Regional Cancer Centre. This work was carried out based on the American Association of Physicists in Medicine (AAPM) Task Group (TG) 119 report. The AAPM TG 119 report recommends CLs as a bench mark for IMRT commissioning and delivery based on its multiple institutions planning and dosimetry comparisons. In this study the locally obtained CLs were compared to TG119 benchmarks. Furthermore, the same bench mark was used to test the capabilities and quality of the VMAT technique in our clinic. The TG 119 test suite consists of two primary and four clinical tests for evaluating the accuracy of IMRT planning and dose delivery systems. Pre defined structure sets contoured on computed tomography images were downloaded from AAPM website and were transferred to a locally designed phantom. For each test case two plans were generated using IMRT and VMAT optimisation. Dose prescriptions and planning objectives recommended by TG119 report were followed to generate the test plans in Eclipse Treatment Planning System. For each plan the point dose measurements were done using an ion chamber at high dose and low dose regions. The planar dose distribution was analysed for percentage of points passing the gamma criteria of 3%/3 mm, for both the composite plan and individual fields of each plan. The CLs were generated based on the results from the gamma analysis and point dose measurements. For IMRT plans, the CLs obtained were (1) from point dose measurements: 2.49% at high dose region and 2.95% for the low dose region (2) from gamma analysis: 2.12% for individual fields and 5.9% for the composite plan. For VMAT plans, the CLs obtained were (1) from point dose measurements: 2.56% at high dose region and 2.6% for the low dose region (2) from gamma analysis: 1.46% for individual fields and 0.8% for

  15. Reliability and Validity of the Turkish Language Version of the Test of Performance Strategies

    Directory of Open Access Journals (Sweden)

    Miçooğulları Bülent Okan

    2017-03-01

    Full Text Available The aim of the present study was to examine the psychometric properties of the Test of Performance Strategies (TOPS; Thomas et al., 1999 on the Turkish population. The TOPS was designed to assess eight psychological skills and strategies used by athletes in competition (activation, automaticity, emotional control, goal-setting, imagery, relaxation, self-talk, and negative thinking and the same strategies, except negative thinking is replaced by attentional control used in training. The sample of the study included athletes who were training and competing in a wide variety of sports across a broad range of performance standards. The final sample consisted of 433 males (mean ± s: age 22.47 ± 5.30 years and 187 females (mean ± s: age 20.97 ± 4.78 years, 620 athletes in total (mean ± s: age 21.25 ± 4.87 years who voluntarily participated; TOPS was administered to all participants. Afterward, Confirmatory Factor Analysis (CFA was conducted by Analysis Moments of Structures (AMOS 18. Comparative fit index (CFI, non-normed fit index (NNFI and root mean square error of approximation (RMSEA were used to verify whether the model fit the data. Goodness-of-fit statistics were CFI= .91, NNFI= .92 and RMSEA= .056. These values showed that the tested model is coherent at a satisfactory level. Moreover, results of confirmatory factor analyses revealed that a total of four items (two items from competition and two from practice within the subscale of automaticity have been removed. The 28 items within the remaining seven subscales have been validated. In conclusion, Turkish version of TOPS is a valid and reliable instrument to assess the psychological skills and strategies used by athletes in competition and practices.

  16. Testing bidirectional associations among emotion regulation strategies and substance use: a daily diary study.

    Science.gov (United States)

    Weiss, Nicole H; Bold, Krysten W; Sullivan, Tami P; Armeli, Stephen; Tennen, Howard

    2017-04-01

    Alcohol and marijuana are widely used among college students. Emotion regulation strategies have been linked to alcohol and marijuana use, but little attention has been devoted to modeling the directionality of these associations. The aims of the current study were to test whether (a) daytime use of emotion regulation strategies influences the likelihood of evening substance use and (b) evening substance use influences the likelihood of next-day use of emotion regulation strategies. Longitudinal daily diary data were collected for 30 days via on-line surveys. Northeastern United States. A total of 1640 college students (mean age = 19.2 years, 54% female, 80% European American) were recruited each semester between Spring 2008 and Spring 2012. Daily diaries assessed emotion regulation strategies (distraction, reappraisal, problem-solving, avoidance) and substance use (any drinking, heavy drinking, marijuana use, co-use of any drinking/heavy drinking and marijuana). Covariates included gender, age, race/ethnicity, fraternity/sorority involvement and baseline depression. Daytime distraction [odds ratio (OR) = 0.95], reappraisal (OR = 0.95) and problem-solving (OR = 0.94) predicted lower odds of evening marijuana use (P-values strategies and substance use: greater daytime use of distraction, reappraisal, and problem solving predicts lower evening substance use, while higher evening substance use predicts higher next-day avoidance and reappraisal but lower next-day problem-solving. © 2016 Society for the Study of Addiction.

  17. [Techniques and strategy of pathological sampling in the diagnostic and therapeutic management of lung cancer].

    Science.gov (United States)

    Remmelink, M; Sokolow, Y; Leduc, D

    2015-04-01

    Histopathology is key to the diagnosis and staging of lung cancer. This analysis requires tissue sampling from primary and/or metastatic lesions. The choice of sampling technique is intended to optimize diagnostic yield while avoiding unnecessarily invasive procedures. Recent developments in targeted therapy require increasingly precise histological and molecular characterization of the tumor. Therefore, pathologists must be economical with tissue samples to ensure that they have the opportunity to perform all the analyses required. More than ever, good communication between clinician, endoscopist or surgeon, and pathologist is essential. This is necessary to ensure that all participants in the process of lung cancer diagnosis collaborate to ensure that the appropriate number and type of biopsies are performed with the appropriate tissue sampling treatment. This will allow performance of all the necessary analyses leading to a more precise characterization of the tumor, and thus the optimal treatment for patients with lung cancer. Copyright © 2015 SPLF. Published by Elsevier Masson SAS. All rights reserved.

  18. Novel bronchoscopic strategies for the diagnosis of peripheral lung lesions: present techniques and future directions.

    Science.gov (United States)

    Gilbert, Christopher; Akulian, Jason; Ortiz, Ricardo; Lee, Hans; Yarmus, Lonny

    2014-07-01

    The diagnosis of the peripheral lung lesion has been a long-standing clinical challenge--balancing accuracy with patient safety. With recent data revealing mortality benefits with lung cancer screening via low-dose computed tomography, now more than ever, clinicians will be challenged with the task of providing the means to provide a safe and minimally invasive method of obtaining accurate tissue diagnostics for the pulmonary nodule. In this review, we present available technologies to aid clinicians in attempts at minimally invasive techniques and the data supporting their use. In addition, we review novel tools under investigation that may further increase yield and provide additional benefit in obtaining an early diagnosis of lung cancer.

  19. Field Evaluation of Alternative Testing Strategies for the Detection of HIV Infection in Beijing

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Objective To identify a cost-efficient alternative antibody testing strategy for screening and confirmation of HIV infection by rapid simple tests (RSTs) and enzyme-linked immunosorbent assays (ELISAs). Methods Four RSTs (RST1,RST2, RST3, and RST4 ) and five ELISAs (ELISA1, ELISA2, ELISA3, ELISA4, and ELISA5) were evaluated in two phases by using banked and serum specimens prospectively collected at regional hospitals and voluntary counseling and testing (VCT)centers in Beijing. A total of 200 banked serum specimens were included in the first phase, including 62 HIV-positive, 127 HIV-negative and 11 indeterminate specimens. All specimens were tested by four RSTs and five ELISAs respectively. The second phase involved prospective testing of 389 routine specimens, including 92 HIV-positive, 287 HIV-negative, and 10 indeterminate specimens. All the specimens were tested by two RSTs (RST2 and RST4) and three ELISAs (ELISA1, ELISA3,and ELISA4), which were selected for their respective excellent sensitivity and/or specificity. Western blot (WB) was used as a gold standard for confirming the reactivity of all the specimens. Results Sensitivity, specificity, and efficacy were calculated for each assay in two phases. In the first phase, four assays (ELISA4, RST2, RST3, and RST4) had a specificity of 100%. For the determination of efficacy, ELISA4, RST2, and RST4 were selected in the second phase. ELISA1 and ELISA3 which have a sensitivity of 95.9% and 93.2% respectively also entered this phase. In the second phase, all the five assays (ELISA1, ELISA3, ELISA4, RST2, and RST4) had a sensitivity and specifity of over 90%. ELISA1 had a sensitivity of 99% and ELISA4 a specificity of 99%. Conclusion The sensitivity ELISA1 and the specificit of ELISA4 are comparable to ELISA/WB standard strategy. Application of this alternative testing strategy provides a cost-effective method for determining HIV prevalence in Beijing.

  20. POC-scale testing of an advanced fine coal dewatering equipment/technique

    Energy Technology Data Exchange (ETDEWEB)

    Groppo, J.G.; Parekh, B.K. [Univ. of Kentucky, Lexington, KY (United States); Rawls, P. [Department of Energy, Pittsburgh, PA (United States)

    1995-11-01

    Froth flotation technique is an effective and efficient process for recovering of ultra-fine (minus 74 {mu}m) clean coal. Economical dewatering of an ultra-fine clean coal product to a 20 percent level moisture will be an important step in successful implementation of the advanced cleaning processes. This project is a step in the Department of Energy`s program to show that ultra-clean coal could be effectively dewatered to 20 percent or lower moisture using either conventional or advanced dewatering techniques. As the contract title suggests, the main focus of the program is on proof-of-concept testing of a dewatering technique for a fine clean coal product. The coal industry is reluctant to use the advanced fine coal recovery technology due to the non-availability of an economical dewatering process. in fact, in a recent survey conducted by U.S. DOE and Battelle, dewatering of fine clean coal was identified as the number one priority for the coal industry. This project will attempt to demonstrate an efficient and economic fine clean coal slurry dewatering process.

  1. Reduced order modelling techniques for mesh movement strategies as applied to fluid structure interactions

    CSIR Research Space (South Africa)

    Bogaers, Alfred EJ

    2010-01-01

    Full Text Available = 30 units, with the initial mesh shown in Figure 1(a). The contour plots use an element shape-size quality indicator defined in [9], where 0 ? fss ? 1, for degenerate and perfect elements respectively. 4.1 Snapshot Generation The first requirement... mesh, generated using NETGEN [17]. (b) Full order mesh optimization. (c) ROM: Coefficient Interpolation. (d) ROM: Coefficient Optimization. Figure 1: Rotation and translation test case. Mesh quality contour plots using quality metric 0 ? fss ? 1 [3...

  2. A Multi-Core Parallelization Strategy for Statistical Significance Testing in Learning Classifier Systems.

    Science.gov (United States)

    Rudd, James; Moore, Jason H; Urbanowicz, Ryan J

    2013-11-01

    Permutation-based statistics for evaluating the significance of class prediction, predictive attributes, and patterns of association have only appeared within the learning classifier system (LCS) literature since 2012. While still not widely utilized by the LCS research community, formal evaluations of test statistic confidence are imperative to large and complex real world applications such as genetic epidemiology where it is standard practice to quantify the likelihood that a seemingly meaningful statistic could have been obtained purely by chance. LCS algorithms are relatively computationally expensive on their own. The compounding requirements for generating permutation-based statistics may be a limiting factor for some researchers interested in applying LCS algorithms to real world problems. Technology has made LCS parallelization strategies more accessible and thus more popular in recent years. In the present study we examine the benefits of externally parallelizing a series of independent LCS runs such that permutation testing with cross validation becomes more feasible to complete on a single multi-core workstation. We test our python implementation of this strategy in the context of a simulated complex genetic epidemiological data mining problem. Our evaluations indicate that as long as the number of concurrent processes does not exceed the number of CPU cores, the speedup achieved is approximately linear.

  3. Comparison of System Identification Techniques for the Hydraulic Manipulator Test Bed (HMTB)

    Science.gov (United States)

    Morris, A. Terry

    1996-01-01

    In this thesis linear, dynamic, multivariable state-space models for three joints of the ground-based Hydraulic Manipulator Test Bed (HMTB) are identified. HMTB, housed at the NASA Langley Research Center, is a ground-based version of the Dexterous Orbital Servicing System (DOSS), a representative space station manipulator. The dynamic models of the HMTB manipulator will first be estimated by applying nonparametric identification methods to determine each joint's response characteristics using various input excitations. These excitations include sum of sinusoids, pseudorandom binary sequences (PRBS), bipolar ramping pulses, and chirp input signals. Next, two different parametric system identification techniques will be applied to identify the best dynamical description of the joints. The manipulator is localized about a representative space station orbital replacement unit (ORU) task allowing the use of linear system identification methods. Comparisons, observations, and results of both parametric system identification techniques are discussed. The thesis concludes by proposing a model reference control system to aid in astronaut ground tests. This approach would allow the identified models to mimic on-orbit dynamic characteristics of the actual flight manipulator thus providing astronauts with realistic on-orbit responses to perform space station tasks in a ground-based environment.

  4. Techniques Employed to Conduct Postshot Drilling at the former Nevada Test Site

    Energy Technology Data Exchange (ETDEWEB)

    Dekin, W D

    2011-04-14

    Postshot drilling provided essential data on the results of the underground nuclear tests conducted at the Nevada Test Site (NTS), now identified as the Nevada National Security Site (NNSS). It was the means by which samples from the zone of interest were obtained for radiochemical analysis. This handbook describes how Lawrence Livermore National Laboratory (LLNL) conducted postshot drilling operations at the NTS, and it provides a general understanding of the process. Postshot drilling is a specialized application of rotary drilling. Accordingly, this handbook gives a brief description of rotary drilling in Section 2 to acquaint the reader with the general subject before proceeding to the specialized techniques used in postshot drilling. In Section 3, the handbook describes the typical postshot drilling situation at the former NTS and the drilling methods used. Section 4 describes the typical sequence of operations in postshot drilling at the former NTS. Detailed information on special equipment and techniques is given in a series of appendices (A through F) at the end of the handbook.

  5. Creep lifing methodologies applied to a single crystal superalloy by use of small scale test techniques

    Energy Technology Data Exchange (ETDEWEB)

    Jeffs, S.P., E-mail: s.p.jeffs@swansea.ac.uk [Institute of Structural Materials, Swansea University, Singleton Park SA2 8PP (United Kingdom); Lancaster, R.J. [Institute of Structural Materials, Swansea University, Singleton Park SA2 8PP (United Kingdom); Garcia, T.E. [IUTA (University Institute of Industrial Technology of Asturias), University of Oviedo, Edificio Departamental Oeste 7.1.17, Campus Universitario, 33203 Gijón (Spain)

    2015-06-11

    In recent years, advances in creep data interpretation have been achieved either by modified Monkman–Grant relationships or through the more contemporary Wilshire equations, which offer the opportunity of predicting long term behaviour extrapolated from short term results. Long term lifing techniques prove extremely useful in creep dominated applications, such as in the power generation industry and in particular nuclear where large static loads are applied, equally a reduction in lead time for new alloy implementation within the industry is critical. The latter requirement brings about the utilisation of the small punch (SP) creep test, a widely recognised approach for obtaining useful mechanical property information from limited material volumes, as is typically the case with novel alloy development and for any in-situ mechanical testing that may be required. The ability to correlate SP creep results with uniaxial data is vital when considering the benefits of the technique. As such an equation has been developed, known as the k{sub SP} method, which has been proven to be an effective tool across several material systems. The current work now explores the application of the aforementioned empirical approaches to correlate small punch creep data obtained on a single crystal superalloy over a range of elevated temperatures. Finite element modelling through ABAQUS software based on the uniaxial creep data has also been implemented to characterise the SP deformation and help corroborate the experimental results.

  6. KRAS mutation: comparison of testing methods and tissue sampling techniques in colon cancer.

    Science.gov (United States)

    Franklin, Wilbur A; Haney, Jerry; Sugita, Michio; Bemis, Lynne; Jimeno, Antonio; Messersmith, Wells A

    2010-01-01

    Treatment of colon carcinoma with the anti-epidermal growth factor receptor antibody Cetuximab is reported to be ineffective in KRAS-mutant tumors. Mutation testing techniques have therefore become an urgent concern. We have compared three methods for detecting KRAS mutations in 59 cases of colon carcinoma: 1) high resolution melting, 2) the amplification refractory mutation system using a bifunctional self-probing primer (ARMS/Scorpion, ARMS/S), and 3) direct sequencing. We also evaluated the effects of the methods of sectioning and coring of paraffin blocks to obtain tumor DNA on assay sensitivity and specificity. The most sensitive and specific combination of block sampling and mutational analysis was ARMS/S performed on DNA derived from 1-mm paraffin cores. This combination of tissue sampling and testing method detected KRAS mutations in 46% of colon tumors. Four samples were positive by ARMS/S, but initially negative by direct sequencing. Cloned DNA samples were retested by direct sequencing, and in all four cases KRAS mutations were identified in the DNA. In six cases, high resolution melting abnormalities could not be confirmed as specific mutations either by ARMS/S or direct sequencing. We conclude that coring of the paraffin blocks and testing by ARMS/S is a sensitive, specific, and efficient method for KRAS testing.

  7. POC-SCALE TESTING OF OIL AGGLOMERATION TECHNIQUES AND EQUIPMENT FOR FINE COAL PROCESSING

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-01-01

    This report covers the technical progress achieved from October 1, 1997 to December 31, 1997 on the POC-Scale Testing of Oil Agglomeration Techniques and Equipment for Fine Coal Processing project. Experimental test procedures and the results related to the processing of coal fines originating from process streams generated at the Shoal Creek Mine preparation plant, owned and operated by the Drummond Company Inc. of Alabama, are described. Two samples of coal fines, namely Cyclone Overflow and Pond Fines were investigated. The batch test results showed that by applying the Aglofloat technology a significant ash removal might be achieved at a very high combustible matter recovery: · for the Cyclone Overflow sample the ash reduction was in the range 50 to 55% at combustible matter recovery about 98% · for the Pond Fines sample the ash reduction was up to 48% at combustible matter recovery up to 85%. Additional tests were carried out with the Alberta origin Luscar Mine coal, which will be used for the parametric studies of agglomeration equipment at the 250 kg/h pilot plant. The Luscar coal is very similar to the Mary Lee Coal Group (processed at Shoal Creek Mine preparation plant) in terms of rank and chemical composition.

  8. Oscillatory hydraulic testing as a strategy for NAPL source zone monitoring: Laboratory experiments

    Science.gov (United States)

    Zhou, YaoQuan; Cardiff, Michael

    2017-05-01

    Non-aqueous phase liquids (NAPLs) have a complex mode of transport in heterogeneous aquifers, which can result in pools and lenses of NAPLs (the ;source zone;) that are difficult to detect and can cause long-term contamination via slow dissolution into groundwater (the ;dissolved plume;). Characterizing the extent and evolution of NAPL contamination within the source zone is a useful strategy for designing and adapting appropriate remedial actions at many contaminated sites. As a NAPL flows into a given aquifer volume, the effective hydraulic conductivity (K) and specific storage (Ss) of the volume changes associated with the viscosity and compressibility of the impinging fluid, meaning that NAPL movement may be detectable with hydraulic testing. Recently, the use of oscillatory pumping tests - in which sinusoidal pumping variations are implemented and oscillatory pressure changes are detected at monitoring locations - has been suggested as a low-impact hydraulic testing strategy for characterizing aquifer properties (Cardiff et al., 2013; Zhou et al., 2016). Here, we investigate this strategy in an experimental laboratory sandbox where dyed vegetable oil is injected and allowed to migrate as a NAPL. Initial qualitative analyses demonstrate that measurable changes in pressure signal amplitude and phase provide clear evidence for NAPL plume emplacement and migration. Using the approach developed in Zhou et al. (2016), we then apply tomographic analyses to estimate the location of effective K changes (representing fluid changes) and their movement throughout time. This approach provides a method for monitoring ongoing NAPL movement without net extraction or injection of fluid, making it advantageous in field remediation applications.

  9. TEM Cell Testing of Cable Noise Reduction Techniques From 2 MHz to 200 MHz - Part 1

    Science.gov (United States)

    Bradley, Arthur T.; Evans, William C.; Reed, Joshua L.; Shimp, Samuel K.; Fitzpatrick, Fred D.

    2008-01-01

    This paper presents empirical results of cable noise reduction techniques as demonstrated in a TEM cell operating with radiated fields from 2 - 200 MHz. It is the first part of a two-paper series. This first paper discusses cable types and shield connections. In the second paper, the effects of load and source resistances and chassis connections are examined. For each topic, well established theories are compared to data from a real-world physical system. Finally, recommendations for minimizing cable susceptibility (and thus cable emissions) are presented. There are numerous papers and textbooks that present theoretical analyses of cable noise reduction techniques. However, empirical data is often targeted to low frequencies (e.g. 100 MHz). Additionally, a comprehensive study showing the relative effects of various noise reduction techniques is needed. These include the use of dedicated return wires, twisted wiring, cable shielding, shield connections, changing load or source impedances, and implementing load- or source-to-chassis isolation. We have created an experimental setup that emulates a real-world electrical system, while still allowing us to independently vary a host of parameters. The goal of the experiment was to determine the relative effectiveness of various noise reduction techniques when the cable is in the presence of radiated emissions from 2 MHz to 200 MHz. The electronic system (Fig. 1) consisted of two Hammond shielded electrical enclosures, one containing the source resistance, and the other containing the load resistance. The boxes were mounted on a large aluminium plate acting as the chassis. Cables connecting the two boxes measured 81 cm in length and were attached to the boxes using standard D38999 military-style connectors. The test setup is shown in Fig. 2. Electromagnetic fields were created using an HP8657B signal generator, MiniCircuits ZHL-42W-SMA amplifier, and an EMCO 5103 TEM cell. Measurements were taken using an Agilent E4401B

  10. Carbon isotope ratio mass spectrometry for detection of endogenous steroid use: a testing strategy.

    Science.gov (United States)

    Ahrens, Brian D; Butch, Anthony W

    2013-07-01

    Isotope ratio mass spectrometry (IRMS) testing is performed to determine if an atypical steroid profile is due to administration of an endogenous steroid. Androsterone (Andro) and etiocholanolone (Etio), and/or the androstanediols (5α- and 5β-androstane-3α,17β-diol) are typically analyzed by IRMS to determine the (13) C/(12) C ratio. The ratios of these target compounds are compared to the (13) C/(12) C ratio of an endogenous reference compound (ERC) such as 5β-pregnane-3α,20α-diol (Pdiol). Concentrations of Andro and Etio are high so (13) C/(12) C ratios can easily be measured in most urine samples. Despite the potentially improved sensitivity of the androstanediols for detecting the use of some testosterone formulations, additional processing steps are often required that increase labour costs and turnaround times. Since this can be problematic when performing large numbers of IRMS measurements, we established thresholds for Andro and Etio that can be used to determine the need for additional androstanediol testing. Using these criteria, 105 out of 2639 urine samples exceeded the Andro and/or Etio thresholds, with 52 of these samples being positive based on Andro and Etio IRMS testing alone. The remaining 53 urine samples had androstanediol IRMS testing performed and 3 samples were positive based on the androstanediol results. A similar strategy was used to establish a threshold for Pdiol to identify athletes with relatively (13) C-depleted values so that an alternative ERC can be used to confirm or establish a true endogenous reference value. Adoption of a similar strategy by other laboratories can significantly reduce IRMS sample processing and analysis times, thereby increasing testing capacity.

  11. Mud Pit Risk-Based Closure Strategy Report, Nevada Test Site, Nevada, Revision 0

    Energy Technology Data Exchange (ETDEWEB)

    Brain Hoenes

    2004-08-01

    This report presents the findings of the human and ecological risk assessment for the NTS mud pits. The risk assessment utilizes data from 52 of the 270 NTS mud pits in conjunction with corroborative data from 87 other DOE mud pits associated with nuclear testing (at locations on the NTS, in the western United States, and Alaska) as well as relevant process knowledge. Based on the risk assessment findings, the report provides a strategy for further evaluation, characterization, and closure of all 270 NTS mud pit CASs using the Streamlined Approach for Environmental Restoration (SAFER).

  12. Method-independent, Computationally Frugal Convergence Testing for Sensitivity Analysis Techniques

    Science.gov (United States)

    Mai, Juliane; Tolson, Bryan

    2017-04-01

    The increasing complexity and runtime of environmental models lead to the current situation that the calibration of all model parameters or the estimation of all of their uncertainty is often computationally infeasible. Hence, techniques to determine the sensitivity of model parameters are used to identify most important parameters or model processes. All subsequent model calibrations or uncertainty estimation procedures focus then only on these subsets of parameters and are hence less computational demanding. While the examination of the convergence of calibration and uncertainty methods is state-of-the-art, the convergence of the sensitivity methods is usually not checked. If any, bootstrapping of the sensitivity results is used to determine the reliability of the estimated indexes. Bootstrapping, however, might as well become computationally expensive in case of large model outputs and a high number of bootstraps. We, therefore, present a Model Variable Augmentation (MVA) approach to check the convergence of sensitivity indexes without performing any additional model run. This technique is method- and model-independent. It can be applied either during the sensitivity analysis (SA) or afterwards. The latter case enables the checking of already processed sensitivity indexes. To demonstrate the method independency of the convergence testing method, we applied it to three widely used, global SA methods: the screening method known as Morris method or Elementary Effects (Morris 1991, Campolongo et al., 2000), the variance-based Sobol' method (Solbol' 1993, Saltelli et al. 2010) and a derivative-based method known as Parameter Importance index (Goehler et al. 2013). The new convergence testing method is first scrutinized using 12 analytical benchmark functions (Cuntz & Mai et al. 2015) where the true indexes of aforementioned three methods are known. This proof of principle shows that the method reliably determines the uncertainty of the SA results when different

  13. [Stress prevention programs--strategies, techniques, effectiveness. Part II. Organizational activities to prevent stress at work].

    Science.gov (United States)

    Małgorzata, W; Merecz, Dorota; Drabek, Marcin

    2010-01-01

    This is the second part of the publication on approaches to occupational stress prevention and a state of the art in different European countries. In this part, stress prevention within an organization is described and discussed. Although there is no one way of tackling stress at work, some recommendations can be formulated to increase the effectiveness of such interventions. The effective stress reducing programs should be aimed both at changes in the organization itself and empowerment of employees' coping with stress resources. It is also important to take the advantage of wide spectrum of methods and techniques (e.g., work redesign, participation, team work, cognitive behavioral methods, relaxation, etc.) remembering that one size does not fit all. The intervention should be carefully planned and adopted to the various branches, an individual organization or department and should be preceded by the identification of stress risks and risk groups. To have the stress prevention program successfully introduced one should also consider factors which may influence (positively or negatively) the process of program implementation.

  14. Blood Conservation Strategies and Liver Transplantation Transfusion-Free Techniques Derived from Jehovah's Witness Surgical Cohorts.

    Science.gov (United States)

    Sheth, Mansi; Kulkarni, Sujit; Dhanireddy, Kiran; Perez, Alexander; Selby, Rick

    2015-01-01

    Red blood cell and component transfusions are a frequent and widely accepted accompaniment of surgical procedures. Although the risk of specific disease transmission via allogeneic blood transfusions (ABT) is very low, the occurrence of transfusion related immune modulation (TRIM) still remains a ubiquitous concern. Recent studies have shown that ABT are linked to increased morbidity and mortality across various specialties, with negative outcomes directly correlated to number of transfusions. Blood conservation methods are therefore necessary to reduce ABT. Acute normo-volemic hemodilution (ANH) along with pre-operative blood augmentation and intraoperative cell salvage are blood conservation techniques utilized in tertiary and even quaternary (transplantation) surgery in Jehovah's Witnesses with excellent outcomes. The many hematologic complications such as anemia, thrombocytopenia and coagulopathies that occur with liver transplantation present a significant barrier when trying to avoid ABT. Despite this, living donor liver transplantation (LDLT) has been successfully performed in a transfusion-free environment, providing valuable insight into the possibilities of limiting ABT and its associated risks in all patients.

  15. Techniques and long-term outcomes of cotton-clipping and cotton-augmentation strategies for management of cerebral aneurysms.

    Science.gov (United States)

    Safavi-Abbasi, Sam; Moron, Felix; Sun, Hai; Oppenlander, Mark E; Kalani, M Yashar S; Mulholland, Celene B; Zabramski, Joseph M; Nakaji, Peter; Spetzler, Robert F

    2016-09-01

    OBJECTIVE To address the challenges of microsurgically treating broad-based, frail, and otherwise complex aneurysms that are not amenable to direct clipping, alternative techniques have been developed. One such technique is to use cotton to augment clipping ("cotton-clipping" technique), which is also used to manage intraoperative aneurysm neck rupture, and another is to reinforce unclippable segments or remnants of aneurysm necks with cotton ("cotton-augmentation" technique). This study reviews the natural history of patients with aneurysms treated with cotton-clipping and cotton-augmentation techniques. METHODS The authors queried a database consisting of all patients with aneurysms treated at Barrow Neurological Institute in Phoenix, Arizona, between January 1, 2004, and December 31, 2014, to identify cases in which cotton-clipping or cotton-augmentation strategies had been used. Management was categorized as the cotton-clipping technique if cotton was used within the blades of the aneurysm clip and as the cotton-clipping technique if cotton was used to reinforce aneurysms or portions of the aneurysm that were unclippable due to the presence of perforators, atherosclerosis, or residual aneurysms. Data were reviewed to assess patient outcomes and annual rates of aneurysm recurrence or hemorrhage after the initial procedures were performed. RESULTS The authors identified 60 aneurysms treated with these techniques in 57 patients (18 patients with ruptured aneurysms and 39 patients with unruptured aneurysms) whose mean age was 53.1 years (median 55 years; range 24-72 years). Twenty-three aneurysms (11 cases of subarachnoid hemorrhage) were treated using cotton-clipping and 37 with cotton-augmentation techniques (7 cases of subarachnoid hemorrhage). In total, 18 patients presented with subarachnoid hemorrhage. The mean Glasgow Outcome Scale (GOS) score at the time of discharge was 4.4. At a mean follow-up of 60.9 ± 35.6 months (median 70 months; range 10-126 months

  16. Flight Test Measurement Techniques for Laminar Flow. Volume 23(Les techniques de mesure en vol des ecoulements laminaires)

    Science.gov (United States)

    2003-10-01

    aspects of Volume 1 and 2 of the original Flight Test Manual , including the flight testing of aircraft systems. The monographs in this series (with the...N. Alemdaroglu, Middle East Technical University, Ankara, Turkey, Prof. L.M.B. da Costa Campos, Instituto Superior Tecnico , Lisboa Codex, Portugal...Defence Research Establishment ITALIE Česká republika Ryvangs Allé 1, P.O. Box 2715 Centro di Documentazione DK-2100 Copenhagen Ø Tecnico

  17. Investigation of CTBT OSI Radionuclide Techniques at the DILUTED WATERS Nuclear Test Site

    Energy Technology Data Exchange (ETDEWEB)

    Baciak, James E.; Milbrath, Brian D.; Detwiler, Rebecca S.; Kirkham, Randy R.; Keillor, Martin E.; Lepel, Elwood A.; Seifert, Allen; Emer, Dudley; Floyd, Michael

    2012-11-01

    Under the Comprehensive Nuclear-Test-Ban Treaty (CTBT), a verification regime that includes the ability to conduct an On-Site Inspection (OSI) will be established. The Treaty allows for an OSI to include many techniques, including the radionuclide techniques of gamma radiation surveying and spectrometry and environmental sampling and analysis. Such radioactivity detection techniques can provide the “smoking gun” evidence that a nuclear test has occurred through the detection and quantification of indicative recent fission products. An OSI faces restrictions in time and manpower, as dictated by the Treaty; not to mention possible logistics difficulties due to the location and climate of the suspected explosion site. It is thus necessary to have a good understanding of the possible source term an OSI will encounter and the proper techniques that will be necessary for an effective OSI regime. One of the challenges during an OSI is to locate radioactive debris that has escaped an underground nuclear explosion (UNE) and settled on the surface near and downwind of ground zero. To support the understanding and selection of sampling and survey techniques for use in an OSI, we are currently designing an experiment, the Particulate Release Experiment (PRex), to simulate a small-scale vent from an underground nuclear explosion. PRex will occur at the Nevada National Security Site (NNSS). The project is conducted under the National Center for Nuclear Security (NCNS) funded by the National Nuclear Security Agency (NNSA). Prior to the release experiment, scheduled for Spring of 2013, the project scheduled a number of activities at the NNSS to prepare for the release experiment as well as to utilize the nuclear testing past of the NNSS for the development of OSI techniques for CTBT. One such activity—the focus of this report—was a survey and sampling campaign at the site of an old UNE that vented: DILUTED WATERS. Activities at DILUTED WATERS included vehicle-based survey

  18. Operational Testing of a Combined Hardware-Software Strategy for Triage of Radiologically-Contaminated Persons.

    Science.gov (United States)

    Waller, Edward J

    2015-08-01

    After a radiological dispersal device (RDD) event, it is possible for radionuclides to enter the human body through inhalation, ingestion, and skin and wound absorption. The dominant pathway will be through inhalation. From a health physics perspective, it is important to know the magnitude of the intake to perform dosimetric assessments. From a medical perspective, removal of radionuclides leading to dose (hence risk) aversion is of high importance. The efficacy of medical decorporation strategies is extremely dependent upon the time of treatment delivery after intake. The "golden hour," or more realistically 3-4 h, is imperative when attempting to increase removal of radionuclides from extracellular fluids prior to cellular incorporation. To assist medical first response personnel in making timely decisions regarding appropriate treatment delivery modes, a software tool has been developed which compiles existing radionuclide decorporation therapy data and allows a user to perform simple triage leading to potential appropriate decorporation treatment strategies. Three triage algorithms were included: (1) multi-parameter model (MPM), (2) clinical decision guidance (CDG) model, and (3) annual limit on intake (ALI) model. A radiation triage mask (RTM) has simultaneously been developed to provide a simple and rapid hardware solution for first responders to triage internally exposed personnel in the field. The hardware/software strategy was field tested with a military medical unit and was found by end-users to be relatively simple to learn and use.

  19. How effective is drug testing as a workplace safety strategy? A systematic review of the evidence.

    Science.gov (United States)

    Pidd, Ken; Roche, Ann M

    2014-10-01

    The growing prevalence of workplace drug testing and the narrow scope of previous reviews of the evidence base necessitate a comprehensive review of research concerning the efficacy of drug testing as a workplace strategy. A systematic qualitative review of relevant research published between January 1990 and January 2013 was undertaken. Inclusion criteria were studies that evaluated the effectiveness of drug testing in deterring employee drug use or reducing workplace accident or injury rates. Methodological adequacy was assessed using a published assessment tool specifically designed to assess the quality of intervention studies. A total of 23 studies were reviewed and assessed, six of which reported on the effectiveness of testing in reducing employee drug use and 17 which reported on occupational accident or injury rates. No studies involved randomised control trials. Only one study was assessed as demonstrating strong methodological rigour. That study found random alcohol testing reduced fatal accidents in the transport industry. The majority of studies reviewed contained methodological weaknesses including; inappropriate study design, limited sample representativeness, the use of ecological data to evaluate individual behaviour change and failure to adequately control for potentially confounding variables. This latter finding is consistent with previous reviews and indicates the evidence base for the effectiveness of testing in improving workplace safety is at best tenuous. Better dissemination of the current evidence in relation to workplace drug testing is required to support evidence-informed policy and practice. There is also a pressing need for more methodologically rigorous research to evaluate the efficacy and utility of drug testing. Copyright © 2014 Elsevier Ltd. All rights reserved.

  20. Novel Strategy to Fabricate Floating Drug Delivery System Based on Sublimation Technique.

    Science.gov (United States)

    Huanbutta, Kampanart; Limmatvapirat, Sontaya; Sungthongjeen, Srisagul; Sriamornsak, Pornsak

    2016-06-01

    The present study aims to develop floating drug delivery system by sublimation of ammonium carbonate (AMC). The core tablets contain a model drug, hydrochlorothiazide, and various levels (i.e., 0-50% w/w) of AMC. The tablets were then coated with different amounts of the polyacrylate polymers (i.e., Eudragit® RL100, Eudragit® RS100, and the mixture of Eudragit® RL100 and Eudragit® RS100 at 1:1 ratio). The coated tablets were kept at ambient temperature (25°C) or cured at 70°C for 12 h before further investigation. The floating and drug release behaviors of the tablets were performed in simulated gastric fluid USP without pepsin at 37°C. The results showed that high amount of AMC induced the floating of the tablets. The coated tablets containing 40 and 50% AMC floated longer than 8 h with a time-to-float of about 3 min. The sublimation of AMC from the core tablets decreased the density of system, causing floating of the tablets. The tablets coated with Eudragit® RL100 floated at a faster rate than those of Eudragit® RS100. Even the coating level of polymer did not influence the time-to-float and floating time of coated tablets containing the same amount of AMC, the drug release from the tablets coated with higher coating level of polymer showed slower drug release. The results suggested that the sublimation technique using AMC is promising for the development of floating drug delivery system.

  1. Evaluation of test-strategies for estimating probability of low prevalence of paratuberculosis in Danish dairy herds

    DEFF Research Database (Denmark)

    Sergeant, E.S.G.; Nielsen, Søren S.; Toft, Nils

    2008-01-01

    . Using this model, five herd-testing strategies were evaluated: (1) milk-ELISA on all lactating cows; (2) milk-ELISA on lactating cows 4 years old; (4) faecal culture on all lactating cows; and (5) milk-ELISA plus faecal culture in series on all lactating cows. The five testing strategies were evaluated...... using observed milk-ELISA results from 19 Danish dairy herds as well as for simulated results from the same herds assuming that they were uninfected. Whole-herd milk-ELISA was the preferred strategy, and considered the most cost-effective strategy of the five alternatives. The five strategies were all...... efficient in detecting infection, i.e. estimating a low Pr-Low in infected herds, however, Pr-Low estimates for milk-ELISA on age-cohorts were too low in simulated uninfected herds and the strategies involving faecal culture were too expensive to be of practical interest. For simulated uninfected herds...

  2. Narrative and framing: a test of an integrated message strategy in the exercise context.

    Science.gov (United States)

    Gray, Jennifer B; Harrington, Nancy G

    2011-03-01

    Health communication interventions encouraging exercise may aid in mitigating the obesity crisis in the United States. Although much research has investigated behavioral predictors of exercise, little work has explored message characteristics most persuasive in the exercise context. The purpose of this study, therefore, was to test a message strategy drawing on previous work in health behavior theory combined with persuasion theories (exemplification theory and prospect theory) to encourage positive exercise attitudes, control beliefs, and intentions. The authors report the results of a controlled experiment testing messages using gain or loss frames and narrative or statistical evidence. Results indicate that gain-framed messages are significantly more successful in promoting positive exercise variables and are perceived as more effective than are loss-framed or control messages. The authors discuss the implications of the results for future research.

  3. In-plane load measuring technique for the strength test of MEMS micro-cantilever

    Institute of Scientific and Technical Information of China (English)

    HUAN Yong; ZHANG Taihua; YANG Yemin

    2006-01-01

    An in-plane load measuring technique is developed to perform the strength test of the micro-cantilever. Based on electromagnetism theorem,Micro UTM (Universal Testing Machine) was in-house made with the load range ±1 N and the displacement range ±300 μm. It applies an in-plane load on the free-end of the micro-cantilever. The load acts as a bending moment for the root of the cantilever, but as a torque for the anchor. The results show that for samples with different sizes the ultimate loads range from 1.3 to 69.8 mN and the calculated torque is approximately proportional to the square of the bonding length. Two failure modes, fracture at the root of the cantilever and fracture at the anchor, are observed by micro examination to the debris, which indicates that there is a critical design to achieve the strength balance between the cantilever and the anchor. The work demonstrates that Micro UTM is a powerful instrument for the strength test of the micro-cantilever and similar micro-structures.

  4. Gamma-ray irradiation tests of CMOS sensors used in imaging techniques

    Directory of Open Access Journals (Sweden)

    Cappello Salvatore G.

    2014-01-01

    Full Text Available Technologically-enhanced electronic image sensors are used in various fields as diagnostic techniques in medicine or space applications. In the latter case the devices can be exposed to intense radiation fluxes over time which may impair the functioning of the same equipment. In this paper we report the results of gamma-ray irradiation tests on CMOS image sensors simulating the space radiation over a long time period. Gamma-ray irradiation tests were carried out by means of IGS-3 gamma irradiation facility of Palermo University, based on 60Co sources with different activities. To reduce the dose rate and realize a narrow gamma-ray beam, a lead-collimation system was purposely built. It permits to have dose rate values less than 10 mGy/s and to irradiate CMOS Image Sensors during operation. The total ionizing dose to CMOS image sensors was monitored in-situ, during irradiation, up to 1000 Gy and images were acquired every 25 Gy. At the end of the tests, the sensors continued to operate despite a background noise and some pixels were completely saturated. These effects, however, involve isolated pixels and therefore, should not affect the image quality.

  5. A strategy for in vitro safety testing of nanotitania-modified textile products

    Energy Technology Data Exchange (ETDEWEB)

    Roszak, Joanna; Stępnik, Maciej; Nocuń, Marek; Ferlińska, Magdalena; Smok-Pieniążek, Anna [Nofer Institute of Occupational Medicine, 8 St Teresy St., 91-348 Łódź (Poland); Grobelny, Jarosław; Tomaszewska, Emilia [University of Lodz, Faculty of Chemistry, 163 Pomorska St, 90-236 Łódź (Poland); Wąsowicz, Wojciech [Nofer Institute of Occupational Medicine, 8 St Teresy St., 91-348 Łódź (Poland); Cieślak, Małgorzata, E-mail: cieslakm@iw.lodz.pl [Textile Research Institute, 118 Gdańska St., 90-520, Łódź (Poland)

    2013-07-15

    Highlights: • Commercially available TiO{sub 2}/Ag nanomaterials (NMs) showed higher cytotoxic effect than TiO{sub 2} NMs. • Both titania NMs in pristine form induced a weak genotoxic effect in in vitro studies. • Cytotoxic effect of textile materials modified with TiO{sub 2}/Ag NMs depended on the mode of the fiber manufacturing. • The strategy of in vitro testing of textile materials modified with NMs was proposed. -- Abstract: Titanium dioxide nanomaterials are extensively used in many applications, also for modification of textile materials. Toxicological assessment of such textile materials is currently seldom performed, mainly because of lack of appropriate guidelines. The aim of the study was to assess cytotoxic and genotoxic potential of commercially available TiO{sub 2} and TiO{sub 2}/Ag NMs in pristine form as well as polypropylene fibers modified with the NMs. Both titania NMs showed a cytotoxic effect on BALB/3T3 clone A31 and V79 fibroblasts after 72-h exposure. Both NMs induced a weak genotoxic effect in comet assay, with TiO{sub 2}/Ag being more active. In vitro micronucleus test on human lymphocytes revealed a weak mutagenic effect of both materials after 24 h of exposure. In contrast, no significant increase in micronuclei frequency was observed in the in vitro micronucleus test on V79 fibroblasts. The 24-h extracts prepared from polypropylene fibers modified with TiO{sub 2}/Ag induced a cytotoxic effect on BALB/3T3 cells which strongly depended on the mode of the fibers manufacturing. The study presents a comprehensive approach to toxicity assessment of textile fibers modified with NMs. Proposed approach may form a good “starting point” for improved future testing strategies.

  6. Using the Astronomy Diagnostic Test to Identify Teaching Strategies that Improve Conceptual Understanding

    Science.gov (United States)

    Deming, G. L.; Hufnagel, B.

    2002-05-01

    The Astronomy Diagnostic Test (ADT) was developed in order to assess learning in undergraduate introductory astronomy classes, but an underlying goal was to use the information supplied by the ADT to improve student learning. The ADT National Project collected pre-course (5346 students) and post-course (3842 students) test results from 97 classes at a variety of institutions in 31 states. These results have been compiled in an extensive database. The overall gain between pre-course and post-course average scores amounts to a disappointing 15%, but significant gains are identifiable for specific questions in individual classes. Results from the ADT National Project database will be presented for specific questions with minimal gains. Astronomy education researchers in Maryland are beginning to use ADT results to identify minimal gain concepts and then to modify and assess instructional strategies with the goal of improving student learning. A comparison will be made between ADT pre-course and post-course responses for several classes in which different teaching methods were used. Successful teaching strategies applicable in a variety of class settings will be offered and instructors are encouraged to become involved in assessing results in their own introductory astronomy classes. This research was supported by the National Science Foundation through grant REC-0089239.

  7. Impact of Breast Reader Assessment Strategy on mammographic radiologists' test reading performance.

    Science.gov (United States)

    Suleiman, Wasfi I; Rawashdeh, Mohammad A; Lewis, Sarah J; McEntee, Mark F; Lee, Warwick; Tapia, Kriscia; Brennan, Patrick C

    2016-06-01

    The detection of breast cancer is somewhat limited by human factors, and thus there is a need to improve reader performance. This study assesses whether radiologists who regularly undertake the education in the form of the Breast Reader Assessment Strategy (BREAST) demonstrate any changes in mammography interpretation performance over time. In 2011, 2012 and 2013, 14 radiologists independently assessed a year-specific BREAST mammographic test-set. Radiologists read a different single test-set once each year, with each comprising 60 digital mammogram cases. Radiologists marked the location of suspected lesions without computer-aided diagnosis (CAD) and assigned a confidence rating of 2 for benign and 3-5 for malignant lesions. The mean sensitivity, specificity, location sensitivity, JAFROC FOM and ROC AUC were calculated. A Kruskal-Wallis test was used to compare the readings for the 14 radiologists across the 3 years. Wilcoxon signed rank test was used to assess comparison between pairs of years. Relationships between changes in performance and radiologist characteristics were examined using a Spearman's test. Significant increases were noted in mean sensitivity (P = 0.01), specificity (P = 0.01), location sensitivity (P = 0.001) and JAFROC FOM (P = 0.001) between 2011 and 2012. Between 2012 and 2013, significant improvements were noted in mean sensitivity (P = 0.003), specificity (P = 0.002), location sensitivity (P = 0.02), JAFROC FOM (P = 0.005) and ROC AUC (P = 0.008). No statistically significant correlations were shown between the levels of improvement and radiologists' characteristics. Radiologists' who undertake the BREAST programme demonstrate significant improvements in test-set performance during a 3-year period, highlighting the value of ongoing education through the use of test-set. © 2016 The Royal Australian and New Zealand College of Radiologists.

  8. A Layer Correlation Technique for ATLAS Calorimetry Calibration at the 2004 ATLAS Combined Beam Test

    CERN Document Server

    Carli, T; Spanò, F; Speckmayer, P

    2008-01-01

    A method for calibrating the response of a segmented calorimeter to hadrons is developed. The ansatz is that information on longitudinal shower fluctuations gained from a principal component analysis of the layer energy depositions can improve energy resolution by correcting for hadronic invisible energy and dead material losses: projections along the eigenvectors of the correlation matrix are used as input for the calibration. The technique is used to reconstruct the energy of pions impinging on the ATLAS calorimeters during the 2004 Barrel Combined Beam Test at the CERN H8 area. Simulated Monte Carlo events are used to derive corrections for invisible energy lost in nuclear reactions and in dead material in front and in between the calorimeters. For pion beams with energies between 20 and 180 GeV, the particle energy is reconstructed within 3% and the resolution is improved by about 20%.

  9. Boosting the accuracy of SPH techniques: Newtonian and special-relativistic tests

    CERN Document Server

    Rosswog, S

    2014-01-01

    We explore measures to increase the accuracy of SPH methods with respect to commonly used standard techniques. Our main focus here is special-relativistic SPH, but all measures can straight forwardly be applied in the Newtonian case as well. The first improvement concerns the calculation of gradients. Here a scheme that requires the (analytical) inversion of a small matrix is explored. For regular particle distributions this scheme yields gradient estimates that are many orders of magnitude more accurate than the standard SPH gradient. We apply such gradients in fully conservative special-relativistic SPH formulations and find in a large number of benchmark tests that they substantially increase SPH's accuracy. As a second measure, we explore a large number of kernel functions. The most commonly used cubic spline SPH kernel performs rather poorly, the best overall results are obtained for a high-order Wendland kernel which allows for only very little sub-resolution particle motion (noise) and enforces a very ...

  10. Ground Truth and Application for the Anisotropic Receiver Functions Technique - Test site KTB: the installation campaign

    Science.gov (United States)

    Bianchi, Irene; Anselmi, Mario; Apoloner, Maria-Theresia; Qorbani, Ehsan; Gribovszki, Katalin; Bokelmann, Götz

    2015-04-01

    The project at hand is a field test around the KTB (Kontinentale Tiefbohrung) site in the Oberpfalz, Southeastern Germany, at the northwestern edge of the Bohemian Massif. The region has been extensively studied through the analysis of several seismic reflection lines deployed around the drilling site. The deep borehole had been placed into gneiss rocks of the Zone Erbendorf-Vohenstrauss. Drilling activity lasted since 1987 to 1994, and it descends down to a depth of 9101 meters. In our experiment, we aim to recover structural information as well as anisotropy of the upper crust using the receiver function technique. This retrieved information will form the base for a comparison between the resulting anisotropy amount and orientation with information of rock samples from up to 9 km depth, and with earlier high-frequency seismic experiments around the drill site. For that purpose, we installed 9 seismic stations, and recorded seismicity continuously for two years.

  11. Development of Modeling and Signal Processing Techniques for Nondestructive Testing of Concrete Structures

    Energy Technology Data Exchange (ETDEWEB)

    Woo, S.K.; Song, Y.C. [Korea Electric Power Research Institute, Taejeon (Korea); Rhim, H.C. [Yonsei University, Seoul (Korea)

    2001-07-01

    Radar method has a potential of being a powerful and effective tool for nondestructive testing(NDT) of concrete structures, roadways, tunnels and airport pavements. Yet, not all of the available features of the method have been fully developed. The advancement of the method can be achieved through the study of electromagnetic properties of concrete, development of computer simulation techniques for radar measurements, application of appropriate radar hardware systems for specific problem areas, and implementation of proper imaging algorithms for the processing of radar measurement data. In this paper, a numerical modeling technique of finite difference-time domain (FD-TD) method has been applied to simulate radar measurements of concrete structures for NDT. The modeling work is found to be useful in predicting radar measurement signal for thickness detection, rebar detection and the detection of delamination inside concrete. Also, an imaging scheme has been developed and proposed for the use of radar in detecting steel reinforcing bars embedded inside concrete. The scheme utilizes the measured data of electromagnetic properties of concrete and impedance mismatch between concrete and the steel bar. The results have shown improved output of the radar measurement compared to commercially available processing methods. (author). 8 refs., 15 figs.

  12. Necking of Q&P steel during uniaxial tensile test with the aid of DIC technique

    Science.gov (United States)

    Ding, Lei; Lin, Jianping; Min, Junying; Pang, Zheng; Ye, You

    2013-05-01

    A lot of research has been focused on the necking process during the plastic deformation of sheet metals, but the localized necking is rarely distinguished form diffused necking by experiments, due to the limit of measurement equipment and method. Quenching and Partitioning (Q&P) steel is a 3rd generation advanced high strength steel (AHSS). Its good combination of high strength and ductility ensures potential application in automobile industry. Uniaxial tensile tests of QP980 steel sheet at five strain rates are performed to investigate the necking process and the effect of strain rate on necking behavior of Q&P steel. Digital image correlation (DIC) method is applied during tensile tests, and evolutions of major strain, minor strain and normal strain distributions along gauge section of the tensile specimens are obtained. The diffused and localized necking strains are determined according to SWIFT necking theory and HILL necking theory respectively. The test results indicate that with the increasing of strain rate in the investigated range, the diffused necking strain decreases from 0.152 to 0.120 and localized necking strain decreases from 0.245 to 0.137. Meanwhile, the difference of the two strains decreases form 0.096 to 0.017. Thus it can be concluded that strain rate has an influence on both necking strains during the deformation of QP980 steel sheet. Diffused and localized necking strains are determined by uniaxial tensile tests with the aid of DIC technique and the effect of strain rate on necking strains is evaluated.

  13. Chemosterilant bait stations coupled with sterile insect technique: an integrated strategy to control the Mediterranean fruit fly (Diptera: Tephritidae).

    Science.gov (United States)

    Navarro-Llopis, V; Vacas, S; Sanchis, J; Primo, J; Alfaro, C

    2011-10-01

    During 2008 and 2009, the efficacy of the combination of two Mediterranean fruit fly, Ceratitis capitata (Wiedemann) (Diptera: Tephritidae), control techniques, sterile insect technique (SIT) and a chemosterilant bait station system (Adress), was tested in three crops: citrus (Citrus spp.), stone fruit (Prunus spp.), and persimmon (Diospyros spp.). Two thousand sterile males were released per ha each week in the whole trial area (50,000 ha, SIT area). For 3,600 ha, within the whole trial area, 24 Adress traps per ha were hung (SIT + Adress area). Ten SIT + Adress plots and 10 SIT plots in each of three different fruit crops were arranged to assess Mediterranean fruit fly population densities and fruit damage throughout the trial period. To evaluate the efficacy of each treatment, the male and female populations were each monitored from August 2008 to November 2009, and injured fruit was assessed before harvest. Results showed a significant reduction in the C. capitata population in plots treated with both techniques versus plots treated only with the SIT. Likewise, a corresponding reduction in the percentage of injured fruit was observed. These data indicate the compatibility of these techniques and suggest the possibility of using Adress coupled with SIT to reduce C. capitata populations in locations with high population densities, where SIT alone is not sufficiently effective to suppress fruit fly populations to below damaging levels.

  14. A strategy to reduce the numbers of fish used in acute ecotoxicity testing of pharmaceuticals.

    Science.gov (United States)

    Hutchinson, Thomas H; Barrett, Sarah; Buzby, Mary; Constable, David; Hartmann, Andreas; Hayes, Eileen; Huggett, Duane; Laenge, Reinhard; Lillicrap, Adam D; Straub, Jürg Oliver; Thompson, Roy S

    2003-12-01

    The pharmaceutical industry gives high priority to animal welfare in the process of drug discovery and safety assessment. In the context of environmental assessments of active pharmaceutical ingredients (APIs), existing U.S. Food and Drug Administration and draft European regulations may require testing of APIs for acute ecotoxicity to algae, daphnids, and fish (base-set ecotoxicity data used to derive the predicted no-effect concentration [PNECwater] from the most sensitive of three species). Subject to regulatory approval, it is proposed that testing can be moved from fish median lethal concentration (LC50) testing (typically using > or = 42 fish/API) to acute threshold tests using fewer fish (typically 10 fish/API). To support this strategy, we have collated base-set ecotoxicity data from regulatory studies of 91 APIs (names coded for commercial reasons). For 73 of the 91 APIs, the algal median effect concentration (EC50) and daphnid EC50 values were lower than or equal to the fish LC50 data. Thus, for approximately 80% of these APIs, algal and daphnid acute EC50 data could have been used in the absence of fish LC50 data to derive PNECwater values. For the other 18 APIs, use of an acute threshold test with a step-down factor of 3.2 is predicted to give comparable PNECwater outcomes. Based on this preliminary scenario of 91 APIs, this approach is predicted to reduce the total number of fish used from 3,822 to 1,025 (approximately 73%). The present study, although preliminary, suggests that the current regulatory requirement for fish LC50 data regarding APIs should be succeeded by fish acute threshold (step-down) test data, thereby achieving significant animal welfare benefits with no loss of data for PNECwater estimates.

  15. Testing the applicability of six macroscopic skeletal aging techniques on a modern Southeast Asian sample.

    Science.gov (United States)

    Gocha, Timothy P; Ingvoldstad, Megan E; Kolatorowicz, Adam; Cosgriff-Hernandez, Meghan-Tomasita J; Sciulli, Paul W

    2015-04-01

    Most macroscopic skeletal aging techniques used by forensic anthropologists have been developed and tested only on reference material from western populations. This study examined the performance of six aging techniques on a known age sample of 88 Southeast Asian individuals. Methods examined included the Suchey-Brooks method of aging the symphyseal face of the os pubis (Brooks and Suchey, Hum. Evol. 5 (1990) 227), Buckberry and Chamberlain's, Am. J. Phys. Anthropol. 119 (2002) 231 and Osborne et al.'s, J. Forensic Sci. 49 (2004) 1 revisions of the Lovejoy et al., Am. J. Phys. Anthropol. 68 (1985) 15 method of aging the auricular surface of the ilium, İşcan et al.'s, J. Forensic Sci. 29 (1984) 1094, İşcan et al.'s, J. Forensic Sci. 30 (1985) 853 method of aging the sternal end of the fourth rib, and Meindl and Lovejoy's, Am. J. Phys. Anthropol. 68 (1985) 57 methods for aging both lateral-anterior and vault sutures on the cranium. The results of this study indicate that application of aging techniques commonly used in forensic anthropology to individuals identified as Asian, and more specifically Southeast Asian, should not be undertaken injudiciously. Of the six individual methods tested here, the Suchey-Brooks pubic symphysis aging method performs best, though average age estimates were still off by nearly 10 years or greater. Methods for aging the auricular surface perform next best, though the Osborne et al. method works better for individuals below 50 years and the Buckberry and Chamberlain method works better for those above 50 years. Methods for age estimation from the sternal ends of the fourth rib and vault and lateral-anterior cranial sutures perform poorly and are not recommended for use on remains of Southeast Asian ancestry. Combining age estimates from multiple indicators, specifically the pubic symphysis and one auricular surface method, was superior to individual methods. Data and a worked example are provided for calculating the conditional

  16. Reliability and Validity Test of Questionnaire on the Adaptation Strategy of Cryosphere Changes in Arid Inland River Basin

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    [Objective] The aim was to test the reliability and validity of questionnaire on the adaptation strategy of cryosphere changes in arid inland river basin. [Method] A questionnaire on "the adaptation strategy of cryosphere changes in arid inland river basin" was carried out in Urumchi River basin and Aksu River basin, and its reliability and validity were tested by means of statistical method, so as to investigate the stability and accuracy of questionnaire. [Result] Reliability analysis of questionnaire sho...

  17. Testing photogrammetry-based techniques for three-dimensional surface documentation in forensic pathology.

    Science.gov (United States)

    Urbanová, Petra; Hejna, Petr; Jurda, Mikoláš

    2015-05-01

    Three-dimensional surface technologies particularly close range photogrammetry and optical surface scanning have recently advanced into affordable, flexible and accurate techniques. Forensic postmortem investigation as performed on a daily basis, however, has not yet fully benefited from their potentials. In the present paper, we tested two approaches to 3D external body documentation - digital camera-based photogrammetry combined with commercial Agisoft PhotoScan(®) software and stereophotogrammetry-based Vectra H1(®), a portable handheld surface scanner. In order to conduct the study three human subjects were selected, a living person, a 25-year-old female, and two forensic cases admitted for postmortem examination at the Department of Forensic Medicine, Hradec Králové, Czech Republic (both 63-year-old males), one dead to traumatic, self-inflicted, injuries (suicide by hanging), the other diagnosed with the heart failure. All three cases were photographed in 360° manner with a Nikon 7000 digital camera and simultaneously documented with the handheld scanner. In addition to having recorded the pre-autopsy phase of the forensic cases, both techniques were employed in various stages of autopsy. The sets of collected digital images (approximately 100 per case) were further processed to generate point clouds and 3D meshes. Final 3D models (a pair per individual) were counted for numbers of points and polygons, then assessed visually and compared quantitatively using ICP alignment algorithm and a cloud point comparison technique based on closest point to point distances. Both techniques were proven to be easy to handle and equally laborious. While collecting the images at autopsy took around 20min, the post-processing was much more time-demanding and required up to 10h of computation time. Moreover, for the full-body scanning the post-processing of the handheld scanner required rather time-consuming manual image alignment. In all instances the applied approaches

  18. Korean Round-Robin Tests Result for New International Program to Assess the Reliability of Emerging Nondestructive Techniques

    Directory of Open Access Journals (Sweden)

    Kyung Cho Kim

    2017-04-01

    Full Text Available The Korea Institute of Nuclear Safety, as a representative organization of Korea, in February 2012 participated in an international Program to Assess the Reliability of Emerging Nondestructive Techniques initiated by the U.S. Nuclear Regulatory Commission. The goal of the Program to Assess the Reliability of Emerging Nondestructive Techniques is to investigate the performance of emerging and prospective novel nondestructive techniques to find flaws in nickel-alloy welds and base materials. In this article, Korean round-robin test results were evaluated with respect to the test blocks and various nondestructive examination techniques. The test blocks were prepared to simulate large-bore dissimilar metal welds, small-bore dissimilar metal welds, and bottom-mounted instrumentation penetration welds in nuclear power plants. Also, lessons learned from the Korean round-robin test were summarized and discussed.

  19. Blade Displacement Measurement Technique Applied to a Full-Scale Rotor Test

    Science.gov (United States)

    Abrego, Anita I.; Olson, Lawrence E.; Romander, Ethan A.; Barrows, Danny A.; Burner, Alpheus W.

    2012-01-01

    Blade displacement measurements using multi-camera photogrammetry were acquired during the full-scale wind tunnel test of the UH-60A Airloads rotor, conducted in the National Full-Scale Aerodynamics Complex 40- by 80-Foot Wind Tunnel. The objectives were to measure the blade displacement and deformation of the four rotor blades as they rotated through the entire rotor azimuth. These measurements are expected to provide a unique dataset to aid in the development and validation of rotorcraft prediction techniques. They are used to resolve the blade shape and position, including pitch, flap, lag and elastic deformation. Photogrammetric data encompass advance ratios from 0.15 to slowed rotor simulations of 1.0, thrust coefficient to rotor solidity ratios from 0.01 to 0.13, and rotor shaft angles from -10.0 to 8.0 degrees. An overview of the blade displacement measurement methodology and system development, descriptions of image processing, uncertainty considerations, preliminary results covering static and moderate advance ratio test conditions and future considerations are presented. Comparisons of experimental and computational results for a moderate advance ratio forward flight condition show good trend agreements, but also indicate significant mean discrepancies in lag and elastic twist. Blade displacement pitch measurements agree well with both the wind tunnel commanded and measured values.

  20. The Effects of a Test-Taking Strategy Intervention for High School Students with Test Anxiety in Advanced Placement Science Courses

    Science.gov (United States)

    Markus, Doron J.

    2011-01-01

    Test anxiety is one of the most debilitating and disruptive factors associated with underachievement and failure in schools (Birenbaum, Menucha, Nasser, & Fadia, 1994; Tobias, 1985). Researchers have suggested that interventions that combine multiple test-anxiety reduction techniques are most effective at reducing test anxiety levels (Ergene,…

  1. Why Take an HIV Test? Concerns, Benefits, and Strategies to Promote HIV Testing among Low-Income Heterosexual African American Young Adults

    Science.gov (United States)

    Wallace, Scyatta A.; McLellan-Lemal, Eleanor; Harris, Muriel J.; Townsend, Tiffany G.; Miller, Kim S.

    2011-01-01

    A qualitative study examined perceptions of HIV testing and strategies to enhance HIV testing among HIV-negative African American heterosexual young adults (ages 18-25 years). Twenty-six focus groups (13 male groups, 13 female groups) were conducted in two low-income communities (urban and rural). All sessions were audio-recorded and transcribed.…

  2. An economic evaluation of preclinical testing strategies compared to the compulsory scrapie flock scheme in the control of classical scrapie.

    Science.gov (United States)

    Boden, Lisa; Handel, Ian; Hawkins, Neil; Houston, Fiona; Fryer, Helen; Kao, Rowland

    2012-01-01

    Cost-benefit is rarely combined with nonlinear dynamic models when evaluating control options for infectious diseases. The current strategy for scrapie in Great Britain requires that all genetically susceptible livestock in affected flocks be culled (Compulsory Scrapie Flock Scheme or CSFS). However, this results in the removal of many healthy sheep, and a recently developed pre-clinical test for scrapie now offers a strategy based on disease detection. We explore the flock level cost-effectiveness of scrapie control using a deterministic transmission model and industry estimates of costs associated with genotype testing, pre-clinical tests and the value of a sheep culled. Benefit was measured in terms of the reduction in the number of infected sheep sold on, compared to a baseline strategy of doing nothing, using Incremental Cost Effectiveness analysis to compare across strategies. As market data was not available for pre-clinical testing, a threshold analysis was used to set a unit-cost giving equal costs for CSFS and multiple pre-clinical testing (MT, one test each year for three consecutive years). Assuming a 40% within-flock proportion of susceptible genotypes and a test sensitivity of 90%, a single test (ST) was cheaper but less effective than either the CSFS or MT strategies (30 infected-sales-averted over the lifetime of the average epidemic). The MT strategy was slightly less effective than the CSFS and would be a dominated strategy unless preclinical testing was cheaper than the threshold price of £6.28, but may be appropriate for flocks with particularly valuable livestock. Though the ST is not currently recommended, the proportion of susceptible genotypes in the national flock is likely to continue to decrease; this may eventually make it a cost-effective alternative to the MT or CSFS.

  3. An economic evaluation of preclinical testing strategies compared to the compulsory scrapie flock scheme in the control of classical scrapie.

    Directory of Open Access Journals (Sweden)

    Lisa Boden

    Full Text Available Cost-benefit is rarely combined with nonlinear dynamic models when evaluating control options for infectious diseases. The current strategy for scrapie in Great Britain requires that all genetically susceptible livestock in affected flocks be culled (Compulsory Scrapie Flock Scheme or CSFS. However, this results in the removal of many healthy sheep, and a recently developed pre-clinical test for scrapie now offers a strategy based on disease detection. We explore the flock level cost-effectiveness of scrapie control using a deterministic transmission model and industry estimates of costs associated with genotype testing, pre-clinical tests and the value of a sheep culled. Benefit was measured in terms of the reduction in the number of infected sheep sold on, compared to a baseline strategy of doing nothing, using Incremental Cost Effectiveness analysis to compare across strategies. As market data was not available for pre-clinical testing, a threshold analysis was used to set a unit-cost giving equal costs for CSFS and multiple pre-clinical testing (MT, one test each year for three consecutive years. Assuming a 40% within-flock proportion of susceptible genotypes and a test sensitivity of 90%, a single test (ST was cheaper but less effective than either the CSFS or MT strategies (30 infected-sales-averted over the lifetime of the average epidemic. The MT strategy was slightly less effective than the CSFS and would be a dominated strategy unless preclinical testing was cheaper than the threshold price of £6.28, but may be appropriate for flocks with particularly valuable livestock. Though the ST is not currently recommended, the proportion of susceptible genotypes in the national flock is likely to continue to decrease; this may eventually make it a cost-effective alternative to the MT or CSFS.

  4. Development of Flight-Test Performance Estimation Techniques for Small Unmanned Aerial Systems

    Science.gov (United States)

    McCrink, Matthew Henry

    This dissertation provides a flight-testing framework for assessing the performance of fixed-wing, small-scale unmanned aerial systems (sUAS) by leveraging sub-system models of components unique to these vehicles. The development of the sub-system models, and their links to broader impacts on sUAS performance, is the key contribution of this work. The sub-system modeling and analysis focuses on the vehicle's propulsion, navigation and guidance, and airframe components. Quantification of the uncertainty in the vehicle's power available and control states is essential for assessing the validity of both the methods and results obtained from flight-tests. Therefore, detailed propulsion and navigation system analyses are presented to validate the flight testing methodology. Propulsion system analysis required the development of an analytic model of the propeller in order to predict the power available over a range of flight conditions. The model is based on the blade element momentum (BEM) method. Additional corrections are added to the basic model in order to capture the Reynolds-dependent scale effects unique to sUAS. The model was experimentally validated using a ground based testing apparatus. The BEM predictions and experimental analysis allow for a parameterized model relating the electrical power, measurable during flight, to the power available required for vehicle performance analysis. Navigation system details are presented with a specific focus on the sensors used for state estimation, and the resulting uncertainty in vehicle state. Uncertainty quantification is provided by detailed calibration techniques validated using quasi-static and hardware-in-the-loop (HIL) ground based testing. The HIL methods introduced use a soft real-time flight simulator to provide inertial quality data for assessing overall system performance. Using this tool, the uncertainty in vehicle state estimation based on a range of sensors, and vehicle operational environments is

  5. Suggesting a testing strategy for possible endocrine effects of drug metabolites.

    Science.gov (United States)

    Jacobsen, N W; Brooks, B W; Halling-Sørensen, B

    2012-04-01

    Most pharmaceuticals are extensively metabolized by organisms, which results in internal exposure to mixtures of parent compounds and various metabolites. Many of these metabolites are considered non-toxic, but some metabolites retain toxic properties of the parent compound or elicit other undesirable outcomes. Unfortunately, the effects of metabolites are often not considered when endocrine activities of chemicals are evaluated in vitro. In this study two approaches, an "effect-based" and a "compound-by-compound" testing design, were used to determine the effects of metabolites of the antidepressant sertraline on aromatase enzyme activity. In the "effect-based" approach, a mixture of sertraline metabolites, produced by liver microsomes, inhibited aromatase, but was less potent than sertraline. In the "compound-by-compound" testing design, three specific metabolites were evaluated individually and in mixtures. Though two N-desmethylated metabolites were more potent aromatase inhibitors than sertraline, hydroxyl ketone sertraline did not inhibit the enzyme and mixtures of these metabolites and sertraline were less potent than predicted from a concentration addition model. Our findings highlight the importance of considering aromatase inhibition, and potentially other biological activities, of pharmaceutical metabolites produced by liver microsome preparations and then comparing such observations to studies of specific metabolites available for testing in pure form. Subsequently, a five step integrated strategy for screening of the potential endocrine effects of drugs and their metabolites are proposed. Copyright © 2012 Elsevier Inc. All rights reserved.

  6. Current strategies to minimize toxicity of oxaliplatin: selection of pharmacogenomic panel tests.

    Science.gov (United States)

    Di Francia, Raffaele; Siesto, Raffaella Stefania; Valente, Daniela; Del Buono, Andrea; Pugliese, Sergio; Cecere, Sabrina; Cavaliere, Carla; Nasti, Guglielmo; Facchini, Gaetano; Berretta, Massimiliano

    2013-11-01

    Oxaliplatin is an anticancer drug routinely used to treat colorectal, gastroesophageal, ovarian, breast, head/neck, and genitourinary cancers. Discontinuation of oxaliplatin treatment is mostly because of peripheral neuropathy, more often than for tumor progression, potentially compromising patient benefit. Several strategies to prevent neurotoxicity have so far been investigated. To overcome this life-threatening side effect, while taking advantage of the antineoplastic activities of oxaliplatin, we describe in detail recent findings on the underlying mechanisms of genetic variants associated with toxicity and resistance to oxaliplatin-based chemotherapy in colorectal cancer. A comprehensive panel of eight polymorphisms, previously validated as significant markers related to oxaliplatin toxicity, is proposed and discussed. In addition, the most common available strategies or methods to prevent/minimize the toxicity were described in detail. Moreover, an early outline evaluation of the genotyping costs and methods was taken in consideration. With the availability of individual pharmacogenomic profiles, the oncologists will have new means to make treatment decisions for their patients that maximize benefit and minimize toxicity. With this purpose in mind, the clinician and lab manager should cooperate to evaluate the advantages and limitations, in terms of costs and applicability, of the most appropriate pharmacogenomic tests for routine incorporation into clinical practice.

  7. The comparison of bolus tracking and test bolus techniques for computed tomography thoracic angiography in healthy beagles

    Directory of Open Access Journals (Sweden)

    Nicolette Cassel

    2013-02-01

    Full Text Available Computed tomography thoracic angiography studies were performed on five adult beagles using the bolus tracking (BT technique and the test bolus (TB technique, which were performed at least two weeks apart. For the BT technique, 2 mL/kg of 300 mgI/mL iodinated contrast agent was injected intravenously. Scans were initiated when the contrast in the aorta reached 150 Hounsfield units (HU. For the TB technique, the dogs received a test dose of 15% of 2 mL/kg of 300 mgI/mL iodinated contrast agent, followed by a series of low dose sequential scans. The full dose of the contrast agent was then administered and the scans were conducted at optimal times as identified from time attenuation curves. Mean attenuation in HU was measured in the aorta (Ao and right caudal pulmonary artery (rCPA. Additional observations included the study duration, milliAmpere (mA, computed tomography dose index volume (CTDI[vol] and dose length product (DLP. The attenuation in the Ao (BT = 660 52 HU ± 138 49 HU, TB = 469 82 HU ± 199 52 HU, p = 0.13 and in the rCPA (BT = 606 34 HU ± 143 37 HU, TB = 413 72 HU ± 174.99 HU, p = 0.28 did not differ significantly between the two techniques. The BT technique was conducted in a significantly shorter time period than the TB technique (p = 0.03. The mean mA for the BT technique was significantly lower than the TB technique (p = 0.03, as was the mean CTDI(vol (p = 0.001. The mean DLP did not differ significantly between the two techniques (p = 0.17. No preference was given to either technique when evaluating the Ao or rCPA but the BT technique was shown to be shorter in duration and resulted in less DLP than the TB technique.

  8. Reliability of clinical diagnosis and laboratory testing techniques currently used for identification of canine parvovirus enteritis in clinical settings

    Science.gov (United States)

    FAZ, Mirna; MARTÍNEZ, José Simón; QUIJANO-HERNÁNDEZ, Israel; FAJARDO, Raúl

    2016-01-01

    Canine parvovirus type 2 (CPV-2) is the main etiological agent of viral enteritis in dogs. Actually in literature, CPV-2 has been reported with clinical signs that vary from the classical disease, and immunochromatography test and PCR technique have been introduced to veterinary hospitals to confirm CPV-2 diagnosis and other infections. However, the reliability of these techniques has been poorly analyzed. In this study, we evaluated the sensitivity and specificity of veterinary clinical diagnosis, immunochromatography test and PCR technique. Our data indicate that variations in the clinical signs of CPV-2 complicate the gathering of an appropriate diagnosis; and immunochromatography test and PCR technique do not have adequate sensitivity to diagnose positive cases. PMID:27818461

  9. Hypothesis Testing, "p" Values, Confidence Intervals, Measures of Effect Size, and Bayesian Methods in Light of Modern Robust Techniques

    Science.gov (United States)

    Wilcox, Rand R.; Serang, Sarfaraz

    2017-01-01

    The article provides perspectives on p values, null hypothesis testing, and alternative techniques in light of modern robust statistical methods. Null hypothesis testing and "p" values can provide useful information provided they are interpreted in a sound manner, which includes taking into account insights and advances that have…

  10. Holospinal epidural abscess of the spinal axis: two illustrative cases with review of treatment strategies and surgical techniques.

    Science.gov (United States)

    Smith, Gabriel A; Kochar, Arshneel S; Manjila, Sunil; Onwuzulike, Kaine; Geertman, Robert T; Anderson, James S; Steinmetz, Michael P

    2014-08-01

    Despite the increasing prevalence of spinal infections, the subcategory of holospinal epidural abscesses (HEAs) is extremely infrequent and requires unique management. Panspinal imaging (preferably MRI), modern aggressive antibiotic therapy, and prompt surgical intervention remain the standard of care for all spinal axis infections including HEAs; however, the surgical decision making on timing and extent of the procedure still remain ill defined for HEAs. Decompression including skip laminectomies or laminoplasties is described, with varied clinical outcomes. In this review the authors present the illustrative cases of 2 patients with HEAs who were treated using skip laminectomies and epidural catheter irrigation techniques. The discussion highlights different management strategies including the role of conservative (nonsurgical) management in these lesions, especially with an already identified pathogen and the absence of mass effect on MRI or significant neurological defects. Among fewer than 25 case reports of HEA published in the past 25 years, the most important aspect in deciding a role for surgery is the neurological examination. Nearly 20% were treated successfully with medical therapy alone if neurologically intact. None of the reported cases had an associated cranial infection with HEA, because the dural adhesion around the foramen magnum prevented rostral spread of infection. Traditionally a posterior approach to the epidural space with irrigation is performed, unless an extensive focal ventral collection is causing cord compression. Surgical intervention for HEA should be an adjuvant treatment strategy for all acutely deteriorating patients, whereas aspiration of other infected sites like a psoas abscess can determine an infective pathogen, and appropriate antibiotic treatment may avoid surgical intervention in the neurologically intact patient.

  11. Cost-Effectiveness Analysis of Different Testing Strategies that Use Antibody Levels to Detect Chronic Hepatitis C in Blood Donors.

    Science.gov (United States)

    Granados-García, Víctor; Contreras, Ana M; García-Peña, Carmen; Salinas-Escudero, Guillermo; Thein, Hla-Hla; Flores, Yvonne N

    2016-01-01

    We conducted a cost-effectiveness analysis of seven hepatitis C virus (HCV) testing strategies in blood donors. Three of the seven strategies were based on HCV diagnosis and reporting guidelines in Mexico and four were from previous and current recommendations outlined by the CDC. The strategies that were evaluated determine antibody levels according to the signal-to-cut-off (S/CO) ratio and use reflex Immunoblot (IMB) or HCV RNA tests to confirm true positive (TP) cases of chronic HCV infection. Costs were calculated from the perspective of the Mexican Institute of Social Security (IMSS). A decision tree model was developed to estimate the expected number of true positive cases and costs for the base-case scenarios and for the sensitivity analyses. Base-case findings indicate an extended dominance of the CDC-USA2 and CDC-USA4 options by the IMSS Mexico3 and IMSS-Mexico1 alternatives. The probabilistic sensitivity analyses results suggest that for a willingness-to-pay (WTP) range of $0-9,000 USD the IMSS-Mexico1 strategy is the most cost-effective of all strategies ($5,000 USD per TP). The IMSS-Mexico3, IMSS-Mexico2, and CDC-USA3 strategies are also cost-effective strategies that cost between $7,800 and $8,800 USD per TP case detected. The CDC-USA1 strategy was very expensive and not cost-effective. HCV antibody testing strategies based on the classification of two or three levels of the S/CO are cost-effective procedures to identify patients who require reflex IMB or HCV RNA testing to confirm chronic HCV infection.

  12. Cost-Effectiveness Analysis of Different Testing Strategies that Use Antibody Levels to Detect Chronic Hepatitis C in Blood Donors

    Science.gov (United States)

    Granados-García, Víctor; Contreras, Ana M.; García-Peña, Carmen; Salinas-Escudero, Guillermo; Thein, Hla-Hla; Flores, Yvonne N.

    2016-01-01

    Aim. We conducted a cost-effectiveness analysis of seven hepatitis C virus (HCV) testing strategies in blood donors. Methods. Three of the seven strategies were based on HCV diagnosis and reporting guidelines in Mexico and four were from previous and current recommendations outlined by the CDC. The strategies that were evaluated determine antibody levels according to the signal-to-cut-off (S/CO) ratio and use reflex Immunoblot (IMB) or HCV RNA tests to confirm true positive (TP) cases of chronic HCV infection. Costs were calculated from the perspective of the Mexican Institute of Social Security (IMSS). A decision tree model was developed to estimate the expected number of true positive cases and costs for the base-case scenarios and for the sensitivity analyses. Results. Base-case findings indicate an extended dominance of the CDC-USA2 and CDC-USA4 options by the IMSS Mexico3 and IMSS-Mexico1 alternatives. The probabilistic sensitivity analyses results suggest that for a willingness-to-pay (WTP) range of $0–9,000 USD the IMSS-Mexico1 strategy is the most cost-effective of all strategies ($5,000 USD per TP). The IMSS-Mexico3, IMSS-Mexico2, and CDC-USA3 strategies are also cost-effective strategies that cost between $7,800 and $8,800 USD per TP case detected. The CDC-USA1 strategy was very expensive and not cost-effective. Conclusions. HCV antibody testing strategies based on the classification of two or three levels of the S/CO are cost-effective procedures to identify patients who require reflex IMB or HCV RNA testing to confirm chronic HCV infection. PMID:27159320

  13. Response Time Evaluation for the Plant Protection System Using a Combined Technique of Analysis and Test

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Chang Jae; Han, Seung; Yun, Jae Hee; Baek, Seung Min [KECO EnC, Inc., Daejeon (Korea, Republic of)

    2015-10-15

    This paper proposes the response time evaluation methodology for the plant protection system (PPS) trip channel for the advance power reactor 1400 (APR1400) nuclear power plant. To demonstrate that the PPS tip channel is functioning within its allowable response time limit, the proposed methodology uses the combined technique of both the response time analysis and test. The main purpose of determining the trip setpoint for safety systems is to meet the requirement of an analytical limit assumed in performing safety analyses. In addition, the response time assumed during safety analyses shall also be satisfied by the safety-related instrumentation. The response time is another critical factor required to ensure that the safety-related instrumentation channels accept the crucial assumptions of safety analyses. The response time evaluation methodology proposed herein is applied to the low steam generator level (LSGL) reactor trip parameter for the APR1400. The response time analysis for the LSGL trip parameter demonstrated that the analyzed response time would not exceed the allocated response time. The results of the response time also showed that all of the measured response times would be less than the analyzed response time.

  14. Monitoring the effectiveness of remediation techniques using sediment toxicity tests with the amphipod Eohaustorius estuarius

    Energy Technology Data Exchange (ETDEWEB)

    Doe, K.G.; Jackman, P.M. [Environment Canada, Moncton, NB (Canada); Lee, K. [Department of Fisheries and Oceans Canada, Dartmouth, NS (Canada)

    2002-07-01

    The results of a controlled oil release experiment of weathered crude oil was presented. The released oil was applied to a tidal saltwater marsh at Conrod's Beach, Nova Scotia, Canada. The study included 3 replicate blocks which included 2 unoiled treatments and 4 oiled treatments for each block. One unoiled site had no treatment, the second unoiled site had nutrient addition to examine the effect of nutrients. The oiled treatments included natural attenuation, nutrient addition, nutrient addition with plants, and nutrient addition with a garden aerator to introduce oxygen. A standard lab procedure was used to analyze the sediments to determine the effectiveness of the technique as well as the toxic effects on the survival of the amphipod Eohaustorius estuarius. Test results indicated that the unoiled sites were non-toxic, with a slight decrease in survival in the treatment with nutrient addition. All the oiled sites were very toxic at first, but toxicity decreased gradually with time. Treatment with nutrient addition with a garden aerator proved to be the most complete and fastest detoxification method. 8 refs., 4 tabs., 2 figs.

  15. Near infrared spectrometric technique for testing fruit quality: optimisation of regression models using genetic algorithms

    Science.gov (United States)

    Isingizwe Nturambirwe, J. Frédéric; Perold, Willem J.; Opara, Umezuruike L.

    2016-02-01

    Near infrared (NIR) spectroscopy has gained extensive use in quality evaluation. It is arguably one of the most advanced spectroscopic tools in non-destructive quality testing of food stuff, from measurement to data analysis and interpretation. NIR spectral data are interpreted through means often involving multivariate statistical analysis, sometimes associated with optimisation techniques for model improvement. The objective of this research was to explore the extent to which genetic algorithms (GA) can be used to enhance model development, for predicting fruit quality. Apple fruits were used, and NIR spectra in the range from 12000 to 4000 cm-1 were acquired on both bruised and healthy tissues, with different degrees of mechanical damage. GAs were used in combination with partial least squares regression methods to develop bruise severity prediction models, and compared to PLS models developed using the full NIR spectrum. A classification model was developed, which clearly separated bruised from unbruised apple tissue. GAs helped improve prediction models by over 10%, in comparison with full spectrum-based models, as evaluated in terms of error of prediction (Root Mean Square Error of Cross-validation). PLS models to predict internal quality, such as sugar content and acidity were developed and compared to the versions optimized by genetic algorithm. Overall, the results highlighted the potential use of GA method to improve speed and accuracy of fruit quality prediction.

  16. Next generation testing strategy for assessment of genomic damage: A conceptual framework and considerations.

    Science.gov (United States)

    Dearfield, Kerry L; Gollapudi, B Bhaskar; Bemis, Jeffrey C; Benz, R Daniel; Douglas, George R; Elespuru, Rosalie K; Johnson, George E; Kirkland, David J; LeBaron, Matthew J; Li, Albert P; Marchetti, Francesco; Pottenger, Lynn H; Rorije, Emiel; Tanir, Jennifer Y; Thybaud, Veronique; van Benthem, Jan; Yauk, Carole L; Zeiger, Errol; Luijten, Mirjam

    2016-09-21

    For several decades, regulatory testing schemes for genetic damage have been standardized where the tests being utilized examined mutations and structural and numerical chromosomal damage. This has served the genetic toxicity community well when most of the substances being tested were amenable to such assays. The outcome from this testing is usually a dichotomous (yes/no) evaluation of test results, and in many instances, the information is only used to determine whether a substance has carcinogenic potential or not. Over the same time period, mechanisms and modes of action (MOAs) that elucidate a wider range of genomic damage involved in many adverse health outcomes have been recognized. In addition, a paradigm shift in applied genetic toxicology is moving the field toward a more quantitative dose-response analysis and point-of-departure (PoD) determination with a focus on risks to exposed humans. This is directing emphasis on genomic damage that is likely to induce changes associated with a variety of adverse health outcomes. This paradigm shift is moving the testing emphasis for genetic damage from a hazard identification only evaluation to a more comprehensive risk assessment approach that provides more insightful information for decision makers regarding the potential risk of genetic damage to exposed humans. To enable this broader context for examining genetic damage, a next generation testing strategy needs to take into account a broader, more flexible approach to testing, and ultimately modeling, of genomic damage as it relates to human exposure. This is consistent with the larger risk assessment context being used in regulatory decision making. As presented here, this flexible approach for examining genomic damage focuses on testing for relevant genomic effects that can be, as best as possible, associated with an adverse health effect. The most desired linkage for risk to humans would be changes in loci associated with human diseases, whether in somatic

  17. Acceptance- and imagery-based strategies can reduce chocolate cravings: A test of the elaborated-intrusion theory of desire.

    Science.gov (United States)

    Schumacher, Sophie; Kemps, Eva; Tiggemann, Marika

    2017-06-01

    The elaborated-intrusion theory of desire proposes that craving is a two-stage process whereby initial intrusions about a desired target are subsequently elaborated with mental imagery. The present study tested whether the craving reduction strategies of cognitive defusion and guided imagery could differentially target the intrusion and elaboration stages, respectively, and thus differentially impact the craving process. Participants were randomly assigned to a cognitive defusion, a guided imagery or a mind-wandering control condition. Pre- and post-intervention chocolate-related thoughts, intrusiveness of thoughts, vividness of imagery, craving intensity, and chocolate consumption were compared. Experiment 1 recruited a general sample of young women (n = 94), whereas Experiment 2 recruited a sample of chocolate cravers who wanted to reduce their chocolate consumption (n = 97). Across both experiments, cognitive defusion lowered intrusiveness of thoughts, vividness of imagery and craving intensity. Guided imagery reduced chocolate-related thoughts, intrusiveness, vividness and craving intensity for chocolate cravers (Experiment 2), but not for the general sample (Experiment 1). There were no group differences in chocolate consumption in either experiment. Results add to existing evidence supporting the elaborated-intrusion theory of desire in the food domain, and suggest that acceptance- and imagery-based techniques have potential for use in combatting problematic cravings. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. Evaluation of the Repeatability of the Delta Q Duct Leakage Testing TechniqueIncluding Investigation of Robust Analysis Techniques and Estimates of Weather Induced Uncertainty

    Energy Technology Data Exchange (ETDEWEB)

    Dickerhoff, Darryl; Walker, Iain

    2008-08-01

    The DeltaQ test is a method of estimating the air leakage from forced air duct systems. Developed primarily for residential and small commercial applications it uses the changes in blower door test results due to forced air system operation. Previous studies established the principles behind DeltaQ testing, but raised issues of precision of the test, particularly for leaky homes on windy days. Details of the measurement technique are available in an ASTM Standard (ASTM E1554-2007). In order to ease adoption of the test method, this study answers questions regarding the uncertainty due to changing weather during the test (particularly changes in wind speed) and the applicability to low leakage systems. The first question arises because the building envelope air flows and pressures used in the DeltaQ test are influenced by weather induced pressures. Variability in wind induced pressures rather than temperature difference induced pressures dominates this effect because the wind pressures change rapidly over the time period of a test. The second question needs to answered so that DeltaQ testing can be used in programs requiring or giving credit for tight ducts (e.g., California's Building Energy Code (CEC 2005)). DeltaQ modeling biases have been previously investigated in laboratory studies where there was no weather induced changes in envelope flows and pressures. Laboratory work by Andrews (2002) and Walker et al. (2004) found biases of about 0.5% of forced air system blower flow and individual test uncertainty of about 2% of forced air system blower flow. The laboratory tests were repeated by Walker and Dickerhoff (2006 and 2008) using a new ramping technique that continuously varied envelope pressures and air flows rather than taking data at pre-selected pressure stations (as used in ASTM E1554-2003 and other previous studies). The biases and individual test uncertainties for ramping were found to be very close (less than 0.5% of air handler flow) to those

  19. AGARD Flight Test Techniques Series. Volume 14. Introduction to Flight Test Engineering (Introduction a la Technique d’essais en vol)

    Science.gov (United States)

    1995-09-01

    W.B. Clarks, 1897. Gast, R. de, "Pax River: the Naval Air Test Center", US Naval Institute Proceedings, Dec. 1969. Gibbs -Smith, C.H., "The Aeroplane...An Historical Survey of Its Origin and Development", London, HMSO, 1960. Gibbs -Smith, C.H., "The Invention of the Aeroplane 1799-1909", New York...145302. 16-6. Dobrzynski, W., "The Effect of Ground Reflections on the Propeller Aircraft Noise Measures LAmax and EPNL", Paper 8th Symposium FASE 󈨝

  20. Use of genotoxicity information in the development of integrated testing strategies (ITS) for skin sensitization.

    Science.gov (United States)

    Mekenyan, Ovanes; Patlewicz, Grace; Dimitrova, Gergana; Kuseva, Chanita; Todorov, Milen; Stoeva, Stoyanka; Kotov, Stefan; Donner, E Maria

    2010-10-18

    Skin sensitization is an end point of concern for various legislation in the EU, including the seventh Amendment to the Cosmetics Directive and Registration Evaluation, Authorisation and Restriction of Chemicals (REACH). Since animal testing is a last resort for REACH or banned (from 2013 onward) for the Cosmetics Directive, the use of intelligent/integrated testing strategies (ITS) as an efficient means of gathering necessary information from alternative sources (e.g., in vitro, (Q)SARs, etc.) is gaining widespread interest. Previous studies have explored correlations between mutagenicity data and skin sensitization data as a means of exploiting information from surrogate end points. The work here compares the underlying chemical mechanisms for mutagenicity and skin sensitization in an effort to evaluate the role mutagenicity information can play as a predictor of skin sensitization potential. The Tissue Metabolism Simulator (TIMES) hybrid expert system was used to compare chemical mechanisms of both end points since it houses a comprehensive set of established structure-activity relationships for both skin sensitization and mutagenicity. The evaluation demonstrated that there is a great deal of overlap between skin sensitization and mutagenicity structural alerts and their underlying chemical mechanisms. The similarities and differences in chemical mechanisms are discussed in light of available experimental data. A number of new alerts for mutagenicity were also postulated for inclusion into TIMES. The results presented show that mutagenicity information can provide useful insights on skin sensitization potential as part of an ITS and should be considered prior to any in vivo skin sensitization testing being initiated.

  1. A multi-stakeholder perspective on the use of alternative test strategies for nanomaterial safety assessment.

    Science.gov (United States)

    Nel, Andre E; Nasser, Elina; Godwin, Hilary; Avery, David; Bahadori, Tina; Bergeson, Lynn; Beryt, Elizabeth; Bonner, James C; Boverhof, Darrell; Carter, Janet; Castranova, Vince; Deshazo, J R; Hussain, Saber M; Kane, Agnes B; Klaessig, Frederick; Kuempel, Eileen; Lafranconi, Mark; Landsiedel, Robert; Malloy, Timothy; Miller, Mary Beth; Morris, Jeffery; Moss, Kenneth; Oberdorster, Gunter; Pinkerton, Kent; Pleus, Richard C; Shatkin, Jo Anne; Thomas, Russell; Tolaymat, Thabet; Wang, Amy; Wong, Jeffrey

    2013-08-27

    There has been a conceptual shift in toxicological studies from describing what happens to explaining how the adverse outcome occurs, thereby enabling a deeper and improved understanding of how biomolecular and mechanistic profiling can inform hazard identification and improve risk assessment. Compared to traditional toxicology methods, which have a heavy reliance on animals, new approaches to generate toxicological data are becoming available for the safety assessment of chemicals, including high-throughput and high-content screening (HTS, HCS). With the emergence of nanotechnology, the exponential increase in the total number of engineered nanomaterials (ENMs) in research, development, and commercialization requires a robust scientific approach to screen ENM safety in humans and the environment rapidly and efficiently. Spurred by the developments in chemical testing, a promising new toxicological paradigm for ENMs is to use alternative test strategies (ATS), which reduce reliance on animal testing through the use of in vitro and in silico methods such as HTS, HCS, and computational modeling. Furthermore, this allows for the comparative analysis of large numbers of ENMs simultaneously and for hazard assessment at various stages of the product development process and overall life cycle. Using carbon nanotubes as a case study, a workshop bringing together national and international leaders from government, industry, and academia was convened at the University of California, Los Angeles, to discuss the utility of ATS for decision-making analyses of ENMs. After lively discussions, a short list of generally shared viewpoints on this topic was generated, including a general view that ATS approaches for ENMs can significantly benefit chemical safety analysis.

  2. Invasive Candidiasis in Various Patient Populations: Incorporating Non-Culture Diagnostic Tests into Rational Management Strategies

    Directory of Open Access Journals (Sweden)

    Cornelius J. Clancy

    2016-02-01

    Full Text Available Mortality rates due to invasive candidiasis remain unacceptably high, in part because the poor sensitivity and slow turn-around time of cultures delay the initiation of antifungal treatment. β-d-glucan (Fungitell and polymerase chain reaction (PCR-based (T2Candida assays are FDA-approved adjuncts to cultures for diagnosing invasive candidiasis, but their clinical roles are unclear. We propose a Bayesian framework for interpreting non-culture test results and developing rational patient management strategies, which considers test performance and types of invasive candidiasis that are most common in various patient populations. β-d-glucan sensitivity/specificity for candidemia and intra-abdominal candidiasis is ~80%/80% and ~60%/75%, respectively. In settings with 1%–10% likelihood of candidemia, anticipated β-d-glucan positive and negative predictive values are ~4%–31% and ≥97%, respectively. Corresponding values in settings with 3%–30% likelihood of intra-abdominal candidiasis are ~7%–51% and ~78%–98%. β-d-glucan is predicted to be useful in guiding antifungal treatment for wide ranges of populations at-risk for candidemia (incidence ~5%–40% or intra-abdominal candidiasis (~7%–20%. Validated PCR-based assays should broaden windows to include populations at lower-risk for candidemia (incidence ≥~2% and higher-risk for intra-abdominal candidiasis (up to ~40%. In the management of individual patients, non-culture tests may also have value outside of these windows. The proposals we put forth are not definitive treatment guidelines, but rather represent starting points for clinical trial design and debate by the infectious diseases community. The principles presented here will be applicable to other assays as they enter the clinic, and to existing assays as more data become available from different populations.

  3. A Multi-Stakeholder Perspective on the Use of Alternative Test Strategies for Nanomaterial Safety Assessment

    Science.gov (United States)

    Nel, Andre E.; Nasser, Elina; Godwin, Hilary; Avery, David; Bahadori, Tina; Bergeson, Lynn; Beryt, Elizabeth; Bonner, James C.; Boverhof, Darrell; Carter, Janet; Castranova, Vince; DeShazo, J. R.; Hussain, Saber M.; Kane, Agnes B.; Klaessig, Fred; Kuempel, Eileen; Lafranconi, Mark; Landsiedel, Robert; Malloy, Timothy; Miller, Mary Beth; Morris, Jeffery; Moss, Kenneth; Oberdorster, Gunter; Pinkerton, Kent; Pleus, Richard C.; Shatkin, Jo Anne; Thomas, Rusty; Tolaymat, Thabet; Wang, Amy; Wong, Jeffrey

    2014-01-01

    There has been a conceptual shift in toxicological studies from describing what happens to explaining how the adverse outcome occurs, thereby enabling a deeper and improved understanding of how biomolecular and mechanistic profiling can inform hazard identification and improve risk assessment. Compared to traditional toxicology methods, which have a heavy reliance on animals, new approaches to generate toxicological data are becoming available for the safety assessment of chemicals, including high-throughput and high-content screening (HTS, HCS). With the emergence of nanotechnology, the exponential increase in the total number of engineered nanomaterials (ENMs) in research, development, and commercialization requires a robust scientific approach to screen ENM safety in humans and the environment rapidly and efficiently. Spurred by the developments in chemical testing, a promising new toxicological paradigm for ENMs is to use alternative test strategies (ATS), which reduce reliance on animal testing through the use of in vitro and in silico methods such as HTS, HCS, and computational modeling. Furthermore, this allows for the comparative analysis of large numbers of ENMs simultaneously and for hazard assessment at various stages of the product development process and overall life cycle. Using carbon nanotubes as a case study, a workshop bringing together national and international leaders from government, industry, and academia was convened at the University of California, Los Angeles to discuss the utility of ATS for decision-making analyses of ENMs. After lively discussions, a short list of generally shared viewpoints on this topic was generated, including a general view that ATS approaches for ENMs can significantly benefit chemical safety analysis. PMID:23924032

  4. Testing the effectiveness of simplified search strategies for updating systematic reviews.

    Science.gov (United States)

    Rice, Maureen; Ali, Muhammad Usman; Fitzpatrick-Lewis, Donna; Kenny, Meghan; Raina, Parminder; Sherifali, Diana

    2017-08-01

    The objective of the study was to test the overall effectiveness of a simplified search strategy (SSS) for updating systematic reviews. We identified nine systematic reviews undertaken by our research group for which both comprehensive and SSS updates were performed. Three relevant performance measures were estimated, that is, sensitivity, precision, and number needed to read (NNR). The update reference searches for all nine included systematic reviews identified a total of 55,099 citations that were screened resulting in final inclusion of 163 randomized controlled trials. As compared with reference search, the SSS resulted in 8,239 hits and had a median sensitivity of 83.3%, while precision and NNR were 4.5 times better. During analysis, we found that the SSS performed better for clinically focused topics, with a median sensitivity of 100% and precision and NNR 6 times better than for the reference searches. For broader topics, the sensitivity of the SSS was 80% while precision and NNR were 5.4 times better compared with reference search. SSS performed well for clinically focused topics and, with a median sensitivity of 100%, could be a viable alternative to a conventional comprehensive search strategy for updating this type of systematic reviews particularly considering the budget constraints and the volume of new literature being published. For broader topics, 80% sensitivity is likely to be considered too low for a systematic review update in most cases, although it might be acceptable if updating a scoping or rapid review. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. Strategy Use for Reading English for General and Specific Academic Purposes in Testing and Nontesting Contexts

    Science.gov (United States)

    Chou, Mu-hsuan

    2013-01-01

    Language-use strategies are considered potentially effective approaches that learners select to accomplish a second- or foreign-language task. In the past three decades, there has been a proliferation of research concerned with learners' strategy use at different levels of language ability and the influence of L1 learner strategies on L2 language…

  6. Selecting Strategies to Reduce High-Risk Unsafe Work Behaviors Using the Safety Behavior Sampling Technique and Bayesian Network Analysis.

    Science.gov (United States)

    Ghasemi, Fakhradin; Kalatpour, Omid; Moghimbeigi, Abbas; Mohammadfam, Iraj

    2017-03-04

    High-risk unsafe behaviors (HRUBs) have been known as the main cause of occupational accidents. Considering the financial and societal costs of accidents and the limitations of available resources, there is an urgent need for managing unsafe behaviors at workplaces. The aim of the present study was to find strategies for decreasing the rate of HRUBs using an integrated approach of safety behavior sampling technique and Bayesian networks analysis. A cross-sectional study. The Bayesian network was constructed using a focus group approach. The required data was collected using the safety behavior sampling, and the parameters of the network were estimated using Expectation-Maximization algorithm. Using sensitivity analysis and belief updating, it was determined that which factors had the highest influences on unsafe behavior. Based on BN analyses, safety training was the most important factor influencing employees' behavior at the workplace. High quality safety training courses can reduce the rate of HRUBs about 10%. Moreover, the rate of HRUBs increased by decreasing the age of employees. The rate of HRUBs was higher in the afternoon and last days of a week. Among the investigated variables, training was the most important factor affecting safety behavior of employees. By holding high quality safety training courses, companies would be able to reduce the rate of HRUBs significantly.

  7. Tools for forming strategies for remediation of forests and park areas in northern Europe after radioactive contamination: background and techniques

    Energy Technology Data Exchange (ETDEWEB)

    Hubbard, L. [Swedish Radiation Protection Authority, SSI (Sweden); Rantavaara, A. [Radiation and Nuclear Safety Autority, STUK (Finland); Andersson, K. [Risoe National Lab., Roskilde (Denmark); Roed, J. [Risoe National Lab., Roskilde (Denmark)

    2002-01-01

    This report compiles background information that can be used in planning appropriate countermeasures for forest and park areas in Denmark, Sweden, Finland and Norway, in case a nuclear accident results in large-scale contamination of forests. The information is formulated to inform the forestry sector and radiation protection experts about the practicality of both forest management techniques and mechanical cleanup methods, for use in their planning of specific strategies that can lead to an optimal use of contaminated forests. Decisions will depend on the site and the actual situation after radioactive deposition to forested areas, but the report provides background information from investigations performed before an accident occurs that will make the process more effective. The report also discusses the radiological consequences of producing energy from biomass contaminated by a major nuclear accident, both in the context of normal bio-fuel energy production and as a means of reducing potentially severe environmental problems in the forest by firing power plants with highly contaminated forest biomass. (au)

  8. Test MaxEnt in Social Strategy Transitions with Experimental Two-Person Constant Sum 2$\\times$2 Games

    CERN Document Server

    Xu, Bin

    2012-01-01

    By using laboratory experimental data, we test the uncertainty of social strategy transitions in various competing environments of fixed paired two-person constant sum $2 \\times 2$ games. It firstly shows that, the distributions of social strategy transitions are not erratic but obey the principle of the maximum entropy (MaxEnt). This finding indicates that human subject social systems and natural systems could have wider common backgrounds.

  9. Assessing the impact of next-generation rapid diagnostic tests on Plasmodium falciparum malaria elimination strategies.

    Science.gov (United States)

    Slater, Hannah C; Ross, Amanda; Ouédraogo, André Lin; White, Lisa J; Nguon, Chea; Walker, Patrick G T; Ngor, Pengby; Aguas, Ricardo; Silal, Sheetal P; Dondorp, Arjen M; La Barre, Paul; Burton, Robert; Sauerwein, Robert W; Drakeley, Chris; Smith, Thomas A; Bousema, Teun; Ghani, Azra C

    2015-12-03

    Mass-screen-and-treat and targeted mass-drug-administration strategies are being considered as a means to interrupt transmission of Plasmodium falciparum malaria. However, the effectiveness of such strategies will depend on the extent to which current and future diagnostics are able to detect those individuals who are infectious to mosquitoes. We estimate the relationship between parasite density and onward infectivity using sensitive quantitative parasite diagnostics and mosquito feeding assays from Burkina Faso. We find that a diagnostic with a lower detection limit of 200 parasites per microlitre would detect 55% of the infectious reservoir (the combined infectivity to mosquitoes of the whole population weighted by how often each individual is bitten) whereas a test with a limit of 20 parasites per microlitre would detect 83% and 2 parasites per microlitre would detect 95% of the infectious reservoir. Using mathematical models, we show that increasing the diagnostic sensitivity from 200 parasites per microlitre (equivalent to microscopy or current rapid diagnostic tests) to 2 parasites per microlitre would increase the number of regions where transmission could be interrupted with a mass-screen-and-treat programme from an entomological inoculation rate below 1 to one of up to 4. The higher sensitivity diagnostic could reduce the number of treatment rounds required to interrupt transmission in areas of lower prevalence. We predict that mass-screen-and-treat with a highly sensitive diagnostic is less effective than mass drug administration owing to the prophylactic protection provided to uninfected individuals by the latter approach. In low-transmission settings such as those in Southeast Asia, we find that a diagnostic tool with a sensitivity of 20 parasites per microlitre may be sufficient for targeted mass drug administration because this diagnostic is predicted to identify a similar village population prevalence compared with that currently detected using

  10. Advancing Risk Analysis for Nanoscale Materials: Report from an International Workshop on the Role of Alternative Testing Strategies for Advancement.

    Science.gov (United States)

    Shatkin, J A; Ong, Kimberly J; Beaudrie, Christian; Clippinger, Amy J; Hendren, Christine Ogilvie; Haber, Lynne T; Hill, Myriam; Holden, Patricia; Kennedy, Alan J; Kim, Baram; MacDonell, Margaret; Powers, Christina M; Sharma, Monita; Sheremeta, Lorraine; Stone, Vicki; Sultan, Yasir; Turley, Audrey; White, Ronald H

    2016-08-01

    The Society for Risk Analysis (SRA) has a history of bringing thought leadership to topics of emerging risk. In September 2014, the SRA Emerging Nanoscale Materials Specialty Group convened an international workshop to examine the use of alternative testing strategies (ATS) for manufactured nanomaterials (NM) from a risk analysis perspective. Experts in NM environmental health and safety, human health, ecotoxicology, regulatory compliance, risk analysis, and ATS evaluated and discussed the state of the science for in vitro and other alternatives to traditional toxicology testing for NM. Based on this review, experts recommended immediate and near-term actions that would advance ATS use in NM risk assessment. Three focal areas-human health, ecological health, and exposure considerations-shaped deliberations about information needs, priorities, and the next steps required to increase confidence in and use of ATS in NM risk assessment. The deliberations revealed that ATS are now being used for screening, and that, in the near term, ATS could be developed for use in read-across or categorization decision making within certain regulatory frameworks. Participants recognized that leadership is required from within the scientific community to address basic challenges, including standardizing materials, protocols, techniques and reporting, and designing experiments relevant to real-world conditions, as well as coordination and sharing of large-scale collaborations and data. Experts agreed that it will be critical to include experimental parameters that can support the development of adverse outcome pathways. Numerous other insightful ideas for investment in ATS emerged throughout the discussions and are further highlighted in this article.

  11. Biomechanical comparison of posterior cruciate ligament reconstruction techniques using cyclic loading tests.

    Science.gov (United States)

    Hiraga, Yasuharu; Ishibashi, Yasuyuki; Tsuda, Eiichi; Toh, Harehiko Tsukada Satoshi

    2006-01-01

    Posterior tibial translation (PTT) of the posterior cruciate ligament (PCL) reconstructed-knee under cyclic loading of 1,000 cycles with a 100-N load was compared between four different procedures, including two reconstructions with patellar tendon graft (transtunnel and inlay techniques) and two reconstructions with hamstring tendon graft (Endobutton and EndoPearl techniques) in twelve fresh-frozen human knees. The EndoPearl technique is a direct tendon fixation using biodegradable interference screws and an anchoring device, while the Endobutton technique is an indirect tendon fixation using a titanium button and surgical tape. The change of PTT after cyclic loading in the Endobutton technique was significantly greater than in the other reconstruction technique. No graft rupture at the killer turn or complete pullout from the bone tunnel was found. The advantage of the inlay technique compared to the transtunnel technique with respect to the posterior stability could not be shown in the current study. Posterior laxity of PCL reconstructed-knees with hamstring tendon graft using the Endobutton technique increased more easily than that with patellar tendon graft. For PCL reconstruction using the hamstring tendon graft, anatomical fixation may be preferable to prevent excessive posterior laxity in the early phase of the rehabilitation protocol.

  12. The application of the acoustic emission technique to stone decay by sodium sulphate in laboratory tests

    Directory of Open Access Journals (Sweden)

    Grossi, C. M.

    1997-03-01

    Full Text Available Acoustic emission was monitored during salt crystallisation cycles in order to study the mechanisms of rock deterioration by sodium sulphate in laboratory tests. Some porous carbonate stones used in Spanish monuments (Cathedral of Oviedo, Murcia and Seo Vella of Lérida were selected for this study. The acoustic emission detected during the different stages of the cycles (immersion, drying and cooling was interpreted to be the result of the salt behaviour inside the stone. The use of this technique has confirmed that this behaviour depends on salt characteristics (solubility, hydration state and polymorphism of anhydrous sodium sulphate and stone porosity and pore network.

    Para determinar los mecanismos de deterioro de las rocas debidos a la acción del sulfato de sodio, se ha registrado la emisión acústica durante ensayos de cristalización de sales en el laboratorio. Para ello, se han seleccionado tres piedras porosas carbonatadas utilizadas como materiales de construcción en monumentos españoles (Catedrales de Oviedo, Murcia y Seo Vella de Lérida. La emisión acústica detectada durante las diferentes etapas de los ciclos (inmersión, secado y enfriamiento se ha interpretado como debida al comportamiento de la sal en el interior de la piedra. Mediante esta técnica se ha confirmado que este comportamiento depende de las características de la sal (solubilidad, diferentes estados de hidratación y el polimorfismo del sulfato de sodio anhidro y de la porosidad y configuración del sistema poroso de las rocas.

  13. Developing and testing solar irradiance forecasting techniques in the Hawaiian Islands region

    Science.gov (United States)

    Matthews, D. K.; Souza, J. M.; Stein, K.

    2014-12-01

    Irradiance variability, primarily driven by cloud formation and advection, can be problematic in the state of Hawaíi, because of the high penetration of distributed solar and the small scale of the island electrical grids. The Hawaíi Natural Energy Institute (HNEI) is developing an operational system in order to research and test new techniques to generate solar forecasts for the Hawaiian Islands. The operational system comprises the following three components.(i) A ground-observation-based advection model, using sky imagers and a ceilometer located at the University of Hawaíi at Mānoa. Every 10 minutes (during daylight hours), this component generates a high-resolution 1 hour Global Horizontal Irradiance (GHI) prediction for a region that is within ~15 km of the instrumentation. (ii) A satellite-image-based advection model, using Geostationary Operational Environmental Satellite (GOES) imagery and the Heliosat-II method. Every 30 minutes (during daylight hours), this component generates a 1 km resolution, 6 hour GHI prediction for the entire Hawaiian Archipelago. (iii) A coupled ocean-atmosphere model, using the Regional Ocean Modeling System (ROMS) model and the Weather Research and Forecasting (WRF) model, including newly available microphysics, shallow convection parameterization, and radiative transfer model options. Nightly, this component generates 48 hour GHI, Direct Normal Irradiance (DNI), and Diffuse Horizontal Irradiance (DHI) predictions for (a) a 10 km resolution domain covering the full Hawaiian Archipelago and (b) a nested 2 km resolution domain covering the islands of Maui, Óahu, and Hawaíi. We discuss the development and validation of the system, and the scales of forecasting accuracy for each component. We also examine the impact of the coupled model on the simulations of surface flux processeses and ocean-atmosphere feedbacks, both of which influence the prediction of regional cloud properties.

  14. Testing techniques and comparisons between theory and test for vibration modes of ring stiffened truncated-cone shells.

    Science.gov (United States)

    Naumann, E. C.

    1972-01-01

    Vibration tests were carried out on truncated-cone shells with widely spaced ring stiffeners. The models were excited by an air shaker for LF modes and by small electrodynamic shakers for HF modes. The Novozhilov thin shell theory according to which a ring is an assembly of an arbitrary number of segments, each being a short truncated-cone shell of uniform thickness, is used in the analysis of the results. A mobile, noncontacting, displacement-sensitive sensor system developed by the author was used in the tests. Tests results are given for a free-free 60-deg cone and for a clamped-free 60-deg cone. The tests are characterized as having considerable value for the classification of prevalent multimode responses in shells of this type.

  15. Efficacy of antibiotic treatment and test-based culling strategies for eradicating brucellosis in commercial swine herds.

    Science.gov (United States)

    Dieste-Pérez, L; Frankena, K; Blasco, J M; Muñoz, P M; de Jong, M C M

    2016-04-01

    Swine brucellosis caused by Brucella suis biovar 2 is an emerging disease in continental Europe. Without effective vaccines being available, the European Food Safety Authority (EFSA) recommends the full depopulation of infected herds as the only strategy to eradicate B. suis outbreaks. Using data collected from 8 herds suffering natural swine brucellosis outbreaks, we assessed the efficacy of four control strategies: (i) oxytetracycline treatment only, as a default scenario, (ii) oxytetracycline treatment combined with skin testing and removal of positive animals, (iii) oxytetracycline treatment combined with serological testing (Rose Bengal test-RBT-and indirect ELISA -iELISA-) and removal of seropositive animals and (iv) oxytetracycline treatment combined with both serological (RBT/iELISA) and skin testing and removal of positive animals. A Susceptible-Infectious-Removal model was used to estimate the reproduction ratio (R) for each strategy. According to this model, the oxytetracycline treatment alone was not effective enough to eradicate the infection. However, this antibiotic treatment combined with diagnostic testing at 4-monthly intervals plus immediate removal of positive animals showed to be effective to eradicate brucellosis independent of the diagnostic test strategy used in an acceptable time interval (1-2 years), depending on the initial number of infected animals.

  16. Intravenous Contrast Material Administration at High-pitch Dual-source CT Coronary Angiography: Bolus-tracking Technique with Shortened Time of Respiratory Instruction Versus Test Bolus Technique

    Institute of Scientific and Technical Information of China (English)

    Kai Sun; Guo-rong Liu; Yue-chun Li; Rui-juan Han; Li-fang Cui; Li-jun Ma; Li-gang Li; Chang-yong Li

    2012-01-01

    Objective To investigate the feasibility of acquiring the similar homogeneous enhancement using bolus-tracking techniques with shortened respiratory time in prospectively electrocardiogram-gated high-pitch spiral acquisition mode (Flash mode) coronary computed tomography angiography (CCTA) compared with test bolus technique.Methods One hundred and eighty-four consecutive patients with mean heart rate ≤65 beats per minute undergoing CCTA were prospectively included in this study.The patients were randomly divided into two groups.Patients in the group A (n=92) instructed to shorten respiratory time received CCTA using bolus-tracking technique with high-pitch spiral acquisition mode (Flash mode),while those in the group B (n=92) underwent CCTA with test bolus technique.The attenuation in the ascending aorta,image noise,contrast-to-noise ratio and radiation doses of the two groups were assessed.Results There were no significant differences in the mean attenuation values in the ascending aorta (483.18±59.07 HU vs.498.7±83.51 HU,P=0.183),image noise (21.4±4.5 HU vs.20.9±4.3 HU,P=0.414),contrast-to-noise ratio (12.1±4.2 vs.13.8±5.1,P=0.31) between the groups A and B.There were no significant differences in the radiation dose of dynamic monitoring scans (0.056±0.026 mSv vs.0.062±0.018 mSv,P=0.068) and radiation dose of angiography (0.94±0.07 mSv vs.0.96±0.15 mSv,P=0.926) between the two groups,while 15 mL less contrast material volume was administered in the group A than the group B.Conclusion Bolus-tracking technique with shortened time of respiratory in Flash mode of dual-source CT yields the similar homogeneous enhancement with less contrast material in comparison to the test bolus technique.

  17. Analysis using formal method and testing technique for the processor module for safety-critical application

    Energy Technology Data Exchange (ETDEWEB)

    Choi, J. Y.; Choi, B. J.; Song, H. J.; Hwang, D. Y.; Song, G. H.; Lee, H. [Korea University, Seoul (Korea, Republic of)

    2008-06-15

    This research is on help develop nuclear power plant control system, through the requirement specification and verification method development. As the result of applying the test method, a test standard was obtain through test documentation writing support and a test document reflecting the standard test activities based on the test standard. The specification and verification of the pCOS system and the unified testing documentation and execution helps the entire project to progress and enable us to achieve necessary documents and technology to develop a safety critical system.

  18. TCV software test and validation tools and technique. [Terminal Configured Vehicle program for commercial transport aircraft operation

    Science.gov (United States)

    Straeter, T. A.; Williams, J. R.

    1976-01-01

    The paper describes techniques for testing and validating software for the TCV (Terminal Configured Vehicle) program which is intended to solve problems associated with operating a commercial transport aircraft in the terminal area. The TCV research test bed is a Boeing 737 specially configured with digital computer systems to carry out automatic navigation, guidance, flight controls, and electronic displays research. The techniques developed for time and cost reduction include automatic documentation aids, an automatic software configuration, and an all software generation and validation system.

  19. Advances in techniques of testing mycobacterial drug sensitivity, and the use of sensitivity tests in tuberculosis control programmes

    Science.gov (United States)

    Canetti, G.; Fox, Wallace; Khomenko, A.; Mahler, H. T.; Menon, N. K.; Mitchison, D. A.; Rist, N.; Šmelev, N. A.

    1969-01-01

    In a paper arising out of an informal international consultation of specialists in the bacteriology of tuberculosis held in 1961, an attempt was made to formulate criteria, and specify technical procedures, for reliable tests of sensitivity (the absolute-concentration method, the resistance-ratio method and the proportion method) to the 3 main antituberculosis drugs (isoniazid, streptomycin and p-aminosalicylic acid). Seven years later, a further consultation was held to review the latest developments in the field and to suggest how sensitivity tests might be put to practical use in tuberculosis control programmes. The participants reached agreement on how to define drug sensitivity and resistance, and stressed the importance of using a discrimination approach to the calibration of sensitivity tests. Their views are contained in the present paper, which also includes descriptions of the sensitivity tests used by the Medical Research Council of Great Britain for first- and second-line drugs (minimal inhibitory concentration and resistance-ratio methods), the two main variants of the proportion method developed by the Institut Pasteur, Paris, and a method for calibrating sensitivity tests. PMID:5309084

  20. Framework for Testing the Effectiveness of Bat and Eagle Impact-Reduction Strategies at Wind Energy Projects

    Energy Technology Data Exchange (ETDEWEB)

    Sinclair, Karin [National Renewable Energy Lab. (NREL), Golden, CO (United States); DeGeorge, Elise [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2016-04-13

    The objectives of this framework are to facilitate the study design and execution to test the effectiveness of bat and eagle impact-reduction strategies at wind energy sites. Through scientific field research, the wind industry and its partners can help determine if certain strategies are ready for operational deployment or require further development. This framework should be considered a living document to be improved upon as fatality-reduction technologies advance from the initial concepts to proven readiness (through project- and technology-specific testing) and as scientific field methods improve.