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Sample records for technical specification improvement

  1. Technical specification improvement through safety margin considerations

    International Nuclear Information System (INIS)

    Howard, R.C.; Jansen, R.L.

    1986-01-01

    Westinghouse has developed an approach for utilizing safety analysis margin considerations to improve plant operability through technical specification revision. This approach relies on the identification and use of parameter interrelations and sensitivities to identify acceptable operating envelopes. This paper summarizes technical specification activities to date and presents the use of safety margin considerations as another viable method to obtain technical specification improvement

  2. Improved technical specifications for Korean NPP

    International Nuclear Information System (INIS)

    Ryu, J. D.; Lee, D. H.; Seong, C. K.

    2002-01-01

    PWRs use Technical Specifications(Tech. Spec.) to ensure safe operation of the plant. Recently, many efforts were made to improve Tech. Spec. and as a result, Improved Standard Technical Specifications(ISTS) have been developed. Korean NPP technical specifications were converted to ISTS format. KAERI also provided supporting documents for technical specification conversion including mark-up's and description of changes. This paper describes and summarizes the results of implementation of ISTS for Korean NPP. The new Tech. Spec. will improve safety of Korean NPP

  3. Probabilistic safety assessment improves surveillance requirements in technical specifications

    International Nuclear Information System (INIS)

    Cepin, M.; Mavko, B.

    1997-01-01

    Probabilistic Safety Assessment is widely becoming the standard method for assessing, maintaining, assuring and improving the nuclear power plant safety. To achieve one of its many potential benefits, the optimization approach of surveillance requirements in technical specifications was developed. Surveillance requirements in technical specifications define the surveillance test intervals for the equipment to be tested and the testing strategy. This optimization approach based mainly on probabilistic safety assessment results consists of three levels: component level, system level and plant level. The application of this optimization approach on system level has shown that the risk based surveillance requirements differ from existing ones in technical specifications

  4. Improved technical specifications and related improvements to safety in commercial Nuclear power plants

    International Nuclear Information System (INIS)

    Hoffman, D.R.; Demitrack, T.; Schiele, R.; Jones, J.C.

    2004-01-01

    Many of the commercial nuclear power plants in the United States (US) have been converting a portion of the plant operating license known as the Technical Specifications (TS) in accordance with a document published by the US Nuclear Regulatory Commission (NRC). The TS prescribe commercial nuclear power plant operating requirements. There are several types of nuclear power plants in the US, based on the technology of different vendors, and there is an NRC document that supports each of the five different vendor designs. The NRC documents are known as the Improved Standard Technical Specifications (ISTS) and are contained in a separate document (NUREG series) for each one of the designs. EXCEL Services Corporation (hereinafter EXCEL) has played a major role in the development of the ISTS and in the development, licensing, and implementation of the plant specific Improved Technical Specifications (ITS) (which is based on the ISTS) for the commercial nuclear power plants in the US that have elected to make this conversion. There are currently 103 operating commercial nuclear power plants in the US and 68 of them have successfully completed the conversion to the ITS and are now operating in accordance with their plant specific ITS. The ISTS is focused mainly on safety by ensuring the commercial nuclear reactors can safely shut down and mitigate the consequences of any postulated transient and accident. It accomplishes this function by including requirements directly associated with safety in a document structured systematically and taking into account some key human factors and technical initiatives. This paper discusses the ISTS including its format, content, and detail, the history of the ISTS, the ITS development, licensing, and implementation process, the safety improvements resulting from a plant conversion to ITS, and the importance of the ITS Project to the industry. (Author)

  5. Technical specification improvements to containment heat removal and emergency core cooling systems: Final report

    International Nuclear Information System (INIS)

    Sullivan, W.P.; Ha, C.; Pentzien, D.C.; Visweswaran, S.

    1988-07-01

    This report presents the results of an analysis for technical specification improvements to the emergency core cooling systems (ECCS) and containment heat removal systems (EPRI Research Project 2142-3). The objective of this project is to further develop a reliability- and risk-based methodology to provide improvements by considering groups of surveillance test intervals and allowed out-of-service times jointly. This was done for the technical specifications for the ECCS, containment heat removal equipment, and supporting systems of a boiling water reactor plant. The project (1) developed a methodology for optimizing groups of surveillance test intervals and allowed out-of-service times jointly, (2) applied the methodology in a case study of a specific operating plant, Hatch-2, and (3) evaluated benefits of the application. The results of the case study demonstrate that beneficial technical specification improvements can be realized with application of the methodology. By tightening a small group of sensitive surveillance test intervals (STIs) and allowed out-of-service times (AOTs), a larger group of less sensitive STIs and AOTs can be extended resulting in an overall plant operating cost improvement without reducing the plant safety. The reliability- and risk-based methodology and results from this project can be effectively applied for technical specification improvements at other operating plants

  6. Risk-based configuration control: Application of PSA in improving technical specifications and operational safety

    International Nuclear Information System (INIS)

    Samanta, P.K.; Kim, I.S.; Vesely, W.E.

    1992-01-01

    Risk-based configuration control is the management of component configurations using a risk perspective to control risk and assure safety. A configuration, as used here, is a set of component operability statuses that define the state of a nuclear power plant. If the component configurations that have high risk implications do not occur, then the risk from the operation of nuclear power plants would be minimal. The control of component configurations, i.e., the management of component statuses, to minimize the risk from components being unavailable, becomes difficult, because the status of a standby safety system component is often not apparent unless it is tested. Controlling plant configuration from a risk-perspective can provide more direct risk control and also more operational flexibility by allowing looser controls in areas unimportant to risk. Risk-based configuration control approaches can be used to replace parts of nuclear power plant Technical Specifications. With the advances in probabilistic safety assessment (PSA) technology, such approaches to improve Technical Specifications and operational safety are feasible. In this paper, we present an analysis of configuration risks, and a framework for risk-based configuration control to achieve the desired control of risk-significant configurations during plant operation

  7. Risk-based configuration control: Application of PSA in improving technical specifications and operational safety

    Energy Technology Data Exchange (ETDEWEB)

    Samanta, P.K.; Kim, I.S. [Brookhaven National Lab., Upton, NY (United States); Vesely, W.E. [Science Applications International Corp., Dublin, OH (United States)

    1992-11-01

    Risk-based configuration control is the management of component configurations using a risk perspective to control risk and assure safety. A configuration, as used here, is a set of component operability statuses that define the state of a nuclear power plant. If the component configurations that have high risk implications do not occur, then the risk from the operation of nuclear power plants would be minimal. The control of component configurations, i.e., the management of component statuses, to minimize the risk from components being unavailable, becomes difficult, because the status of a standby safety system component is often not apparent unless it is tested. Controlling plant configuration from a risk-perspective can provide more direct risk control and also more operational flexibility by allowing looser controls in areas unimportant to risk. Risk-based configuration control approaches can be used to replace parts of nuclear power plant Technical Specifications. With the advances in probabilistic safety assessment (PSA) technology, such approaches to improve Technical Specifications and operational safety are feasible. In this paper, we present an analysis of configuration risks, and a framework for risk-based configuration control to achieve the desired control of risk-significant configurations during plant operation.

  8. Risk-based configuration control: Application of PSA in improving technical specifications and operational safety

    Energy Technology Data Exchange (ETDEWEB)

    Samanta, P.K.; Kim, I.S. (Brookhaven National Lab., Upton, NY (United States)); Vesely, W.E. (Science Applications International Corp., Dublin, OH (United States))

    1992-01-01

    Risk-based configuration control is the management of component configurations using a risk perspective to control risk and assure safety. A configuration, as used here, is a set of component operability statuses that define the state of a nuclear power plant. If the component configurations that have high risk implications do not occur, then the risk from the operation of nuclear power plants would be minimal. The control of component configurations, i.e., the management of component statuses, to minimize the risk from components being unavailable, becomes difficult, because the status of a standby safety system component is often not apparent unless it is tested. Controlling plant configuration from a risk-perspective can provide more direct risk control and also more operational flexibility by allowing looser controls in areas unimportant to risk. Risk-based configuration control approaches can be used to replace parts of nuclear power plant Technical Specifications. With the advances in probabilistic safety assessment (PSA) technology, such approaches to improve Technical Specifications and operational safety are feasible. In this paper, we present an analysis of configuration risks, and a framework for risk-based configuration control to achieve the desired control of risk-significant configurations during plant operation.

  9. Review of technical specifications

    International Nuclear Information System (INIS)

    Bedrich, M.; Scholz, D.

    1980-01-01

    The present paper deals with position and function of technical specifications before and during the manufacturing of reactor components, their structure and reasons for specific regulations due to safety philosophy and explains the cooperation of supplier, manufacturer, utilities and supervisory organizations. (RW)

  10. Standard Technical Specifications, Westinghouse plants

    International Nuclear Information System (INIS)

    1992-09-01

    This NUREG contains improved Standard Technical Specifications (STS) for Westinghouse Plants and documents the positions of the Nuclear Regulatory Commission based on the Westinghouse Owners Group's proposed STS. This document is the result of extensive technical meetings and discussions among the NRC staff, the Nuclear Steam Supply System (NSSS) Owners Groups, the NSSS vendors, and the Nuclear Management and Resources Council (NUMARC). The improved STS were developed based on the criteria in the interim Commission Policy Statement on Technical Specification Improvements for Nuclear Power Reactors, dated February 6, 1987. The improved STS will be used as the basis for individual nuclear power plant licensees to develop improved plant-specific technical specifications. This report contains three volumes. This document, Volume 1, contains the Specifications for all chapters and sections of the improved STS. Volume 2 contains the Bases for Chapters 2.0 and 3.0, and Sections 3.1--3.3 of the improved STS. Volume 3 contains the Bases for Sections 3.4--3.9 of the improved STS

  11. Standard technical specifications combustion engineering plants

    International Nuclear Information System (INIS)

    1992-09-01

    This report documents the results of the combined effort of the NRC and the industry to produce improved Standard Technical Specifications (STS) for Combustion Engineering Plants. The improved STS wee developed based on the criteria in the interim Commission Policy Statement on Technical Specification Improvements for Nuclear Power Reactors, dated February 6, 1987. The improved STS will be used as the basis for individual nuclear power plant licensees to develop improved plant-specific technical specifications. This report contains three volumes. This document, Volume 1, contains the Specifications for all chapters and sections of the improved STS. Volume 2 contains the Bases for Sections 3.4--3.9 of the improved STS

  12. Standard Technical Specifications, Babcock and Wilcox plants

    International Nuclear Information System (INIS)

    1992-09-01

    This NUREG contains improved Standard Technical Specifications (STS) for Babcock and Wilcox (B ampersand W) Plants and documents the positions of the Nuclear Regulatory Commission based on the B ampersand W Owners Group's proposed STS. This document is the result of extensive technical meetings and discussions among the NRC staff, the Nuclear Steam Supply System (NSSS) Owners Groups, the NSSS vendors, and the Nuclear Management and Resources Council (NUMARC). The unproved STS were developed based on the, criteria in the interim Commission Policy Statement on Technical Specification Improvements for Nuclear Power Reactors, dated February 6, 1987. The improved STS will be used as the basis for individual nuclear power plant licensees to develop proved plant-specific technical specifications. This report contains three volumes. This document, Volume 1 contains the Specifications for all chapters and sections of the improved STS

  13. HPCG Benchmark Technical Specification

    Energy Technology Data Exchange (ETDEWEB)

    Heroux, Michael Allen [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Dongarra, Jack [Univ. of Tennessee, Knoxville, TN (United States); Luszczek, Piotr [Univ. of Tennessee, Knoxville, TN (United States)

    2013-10-01

    The High Performance Conjugate Gradient (HPCG) benchmark [cite SNL, UTK reports] is a tool for ranking computer systems based on a simple additive Schwarz, symmetric Gauss-Seidel preconditioned conjugate gradient solver. HPCG is similar to the High Performance Linpack (HPL), or Top 500, benchmark [1] in its purpose, but HPCG is intended to better represent how today’s applications perform. In this paper we describe the technical details of HPCG: how it is designed and implemented, what code transformations are permitted and how to interpret and report results.

  14. Standard Technical Specifications, Babcock and Wilcox Plants

    International Nuclear Information System (INIS)

    1992-09-01

    This NUREG contains improved Standard Technical Specifications (STS) for Babcock and Wilcox (B ampersand W) plants and documents the positions of the Nuclear Regulatory Commission (NRC) based on the B ampersand W Owners Group's proposed STS. This document is the result of extensive technical meetings and discussions among the NRC staff, the Nuclear Steam Supply System (NSSS) Owners Groups, the NSSS vendors, and the Nuclear Management and Resources Council. The improved STS were developed based on the criteria in the interim Commission Policy Statement on Technical Specification Improvements for Nuclear Power Reactors, dated February 6, 1987. The improved STS will be used as the basis for developing improved plant-specific technical specifications by individual nuclear power plant licensees. This volume contains sections 3.4--3.9 which cover: Reactor coolant systems, emergency core cooling systems, containment systems, plant systems, electrical power systems, refueling operations

  15. ATR Technical Specification Upgrade Program

    International Nuclear Information System (INIS)

    McCracken, R.T.; Durney, J.L.; Freund, G.A.

    1990-01-01

    The Advanced Test Reactor (ATR) is a 250 MW, uranium-aluminum fueled test reactor which began full power operation in 1969. The initial operation was controlled by an Operating Limits document based on the original Safety Analysis Report. Additional safety bases were later developed to support Technical Specifications which were approved and implemented in 1977. The Technical Specifications which were initially developed with content and format specified in ANSI/ANS--15.1, ''The Development of Technical Specifications for Research Reactors.'' The safety basis documentation and the Technical Specifications have been updated as required to maintain them current with the ATR facility configuration. All revisions have been made with a content, format and style consistent with the original. A major, two-phase program to upgrade the content, format and style is in progress. This paper describes the first phase of this program

  16. ATR technical specification upgrade program

    International Nuclear Information System (INIS)

    McCraken, R.T.; Durney, J.L.; Freund, G.A.

    1990-01-01

    The Advanced Test Reactor (ATR) is a 250 MW, uranium-aluminum fueled test reactor which began full power operation in 1969. The initial operation was controlled by an Operating Limits document based on the original Safety Analysis Report. Additional safety bases were later developed to support Technical Specifications which were approved and implemented in 1977. The Technical Specifications were initially developed with the content and format specified in ANSI/ANS-15.1, The Development of Technical Specifications for Research Reactors. The safety basis documentation and the Technical Specifications have been updated as required to maintain them current with the ATR facility configuration. All revisions have been made with a content, format and style consistent with the original. A major, two-phase program to upgrade the content, format and style is in progress. This paper describes the first phase of this program

  17. Standard technical specifications, Westinghouse Plants: Specifications. Volume 1, Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-04-01

    This NUREG contains the improved Standard Technical Specifications (STS) for Westinghouse plants. Revision 1 incorporates the cumulative changes to Revision 0, which was published in September 1992. The changes reflected in Revision 1 resulted from the experience gained from license amendment applications to convert to these improved STS or to adopt partial improvements to existing technical specifications. This NUREG is the result of extensive public technical meetings and discussions between the Nuclear Regulatory Commission (NRC) staff and various nuclear power plant licensees, Nuclear Steam Supply System (NSSS) Owners Groups, specifically the Westinghouse Owners Group (WOG), NSSS vendors, and the Nuclear Energy Institute (NEI). The improved STS were developed based on the criteria in the Final Commission Policy Statement on Technical Specifications Improvements for Nuclear Power Reactors, dated July 22, 1993 (58 FR 39132). Licensees are encouraged to upgrade their technical specifications consistent with those criteria and conforming, to the extent practical and consistent with the licensing basis for the facility, to Revision 1 to the improved STS. The Commission continues to place the highest priority on requests for complete conversions to the improved STS. Licensees adopting portions of the improved STS to existing technical specifications should adopt all related requirements, as applicable, to achieve a high degree of standardization and consistency.

  18. Optimization and improvement of the technical specifications for Santa Maria de Garona and Cofrentes nuclear power plants

    International Nuclear Information System (INIS)

    Norte Gomez, M.D.; Alcantud, F.; Hoyo, C. del

    1993-01-01

    Technical Specifications (TS) form one of the basic documents necessary for licensing nuclear power plants and are required by the Government in accordance with Article 26 of the Regulation for Nuclear and Radioactive Facilities. They contain specific plant characteristics and operating limits to provide adequate protection for the safety and health of operators and the general public. For operator actuation, TS include all the surveillance requirements and limiting operating conditions (operation at full power, startup, hot and cold shutdown, and refueling outage) of safety-related systems. They also include the conventional support systems which are necessary to keep the plant in a safe operating conditioner to bring it to safe shutdown in the event of incidents or hypothetical accidents. Because of the large volume of information contained in the TS, the NRC and American utility owners began to simplify and improve the initial standard TS, which has given way to the development of a TS Optimization Program in the USA under the auspices of the NRC. Empresarios Agrupados has been contracted by the BWR Spanish Owners' Group (GPE-BWR) to develop optimized TS for the Santa Maria de Garona and Cofrentes Nuclear Power Plants. The optimized and improved TS are simplified versions of the current ones and facilitate the work of plant operators. They help to prevent risks, and reduce the number of potential transients caused by the large number of tests required by current TS. Plant operational safety is enhanced and higher effective operation is achieved. The GPE-BWR has submitted the first part of the optimized TS with their corresponding Bases to the Spanish Nuclear Council (CSN), for comment and subsequent approval. Once the TS are approved by the Spanish Nuclear Council, the operators of the Santa Maria de Garona and Cofrentes Nuclear Power Plants will be given a training and adaptation course prior to their implementation. (author)

  19. Technical specifications, Hanford production reactors

    Energy Technology Data Exchange (ETDEWEB)

    Gilbert, W.D. [comp.

    1962-06-25

    These technical specifications are applicable to the eight operating production reactor facilities, B, C, D, DR, F, H, KE, and KW. Covered are operating and performance restrictions and administrative procedures. Areas covered by the operating and performance restrictions are reactivity, reactor control and safety elements, power level, temperature and heat flux, reactor fuel loadings, reactor coolant systems, reactor confinement, test facilities, code compliance, and reactor scram set points. Administrative procedures include process control procedures, training programs, audits and inspections, and reports and records.

  20. Improving the action requirements of technical specifications: A risk-comparison of continued operation and plant shutdown

    International Nuclear Information System (INIS)

    Kim, I.S.; Samanta, P.K.

    1994-01-01

    When the systems needed to remove decay heat are inoperable or degraded, the risk of shutting down the plant may be comparable to, or even higher than, that of continuing power operation with the equipment inoperable while giving priority to repairs. This concern arises because the plant may not have sufficient capability for removing decay heat during the shutdown. However, Technical Specifications (TSs) often require ''immediate'' shutdown of the plant. In this paper, the authors present risk-based analyses of the various operational policy alternatives available in such situations, with an example application to the standby service water (SSW) system of a BWR. These analyses can be used to define risk-effective requirements for those standby safety systems under discussion

  1. Central Solenoid Insert Technical Specification

    Energy Technology Data Exchange (ETDEWEB)

    Martovetsky, Nicolai N [ORNL; Smirnov, Alexandre [ORNL

    2011-09-01

    The US ITER Project Office (USIPO) is responsible for the ITER central solenoid (CS) contribution to the ITER project. The Central Solenoid Insert (CSI) project will allow ITER validation the appropriate lengths of the conductors to be used in the full-scale CS coils under relevant conditions. The ITER Program plans to build and test a CSI to verify the performance of the CS conductor. The CSI is a one-layer solenoid with an inner diameter of 1.48 m and a height of 4.45 m between electric terminal ends. The coil weight with the terminals is approximately 820 kg without insulation. The major goal of the CSI is to measure the temperature margin of the CS under the ITER direct current (DC) operating conditions, including determining sensitivity to load cycles. Performance of the joints, ramp rate sensitivity, and stability against thermal or electromagnetic disturbances, electrical insulation, losses, and instrumentation are addressed separately and therefore are not major goals in this project. However, losses and joint performance will be tested during the CSI testing campaign. The USIPO will build the CSI that will be tested at the Central Solenoid Model Coil (CSMC) Test Facility at the Japan Atomic Energy Agency (JAEA), Naka, Japan. The industrial vendors (the Suppliers) will report to the USIPO (the Company). All approvals to proceed will be issued by the Company, which in some cases, as specified in this document, will also require the approval of the ITER Organization. Responsibilities and obligations will be covered by respective contracts between the USIPO, called Company interchangeably, and the industrial Prime Contractors, called Suppliers. Different stages of work may be performed by more than one Prime Contractor, as described in this specification. Technical requirements of the contract between the Company and the Prime Contractor will be covered by the Fabrication Specifications developed by the Prime Contractor based on this document and approved by

  2. Identifying priority technical and context-specific issues in improving the conduct, reporting and use of health economic evaluation in low- and middle-income countries.

    Science.gov (United States)

    Luz, Alia; Santatiwongchai, Benjarin; Pattanaphesaj, Juntana; Teerawattananon, Yot

    2018-02-05

    The use of economic evaluation in healthcare policies and decision-making, which is limited in low- and middle-income countries (LMICs), might be promoted through the improvement of the conduct and reporting of studies. Although the literature indicates that there are many issues affecting the conduct, reporting and use of this evidence, it is unclear which factors should be prioritised in finding solutions. This study aims to identify the top priority issues that impede the conduct, reporting and use of economic evaluation as well as potential solutions as an input for future research topics by the international Decision Support Initiative and other movements. A survey on issues regarding the conduct, reporting and use of economic evaluation as well as on potential solutions was conducted using an online questionnaire among researchers who have experience in conducting economic evaluations in LMICs. The respondents were requested to consider the list of issues provided, rank the most important ones and propose solutions. A scoring system was applied to derive the ranking of difficulties according to researchers' responses. Issues were grouped into technical and context-specific difficulties and analysed separately as a whole and by region. Researchers considered the lack of quality local clinical data, poor reporting and insufficient data to conduct the analysis from the chosen perspective as the most important technical difficulties. On the other hand, the non-integration of economic evaluations into decision-making was considered the most important context-specific issue. Finally, context-specific issues were considered the larger barrier to the use of economic evaluation. The technical issues that were considered most important were closely linked with the lack of an appropriately functioning information system as well as the capacity to generate essential contextual information (e.g. data and locally relevant utility values), especially when the methodology is

  3. Standard technical specifications: Babcock and Wilcox Plants. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-04-01

    This report documents the results of the combined effort of the NRC and the industry to produce improved Standard Technical Specifications (STS), Revision 1 for Babcock & Wilcox Plants. The changes reflected in Revision 1 resulted from the experience gained from license amendment applications to convert to these improved STS or to adopt partial improvements to existing technical specifications. This NUREG is the result of extensive public technical meetings and discussions between the Nuclear Regulatory Commission (NRC) staff and various nuclear power plant licensees, Nuclear Steam Supply System (NSSS) Owners Groups, NSSS vendors, and the Nuclear Energy Institute (NEI). The improved STS were developed based on the criteria in the Final Commission Policy Statement on Technical Specifications Improvements for Nuclear Power Reactors, dated July 22, 1993. The improved STS will be used as the basis for individual nuclear power plant licensees to develop improved plant-specific technical specifications. This report contains three volumes. Volume 1 contains the Specifications for all chapters and sections of the improved STS. Volume 2 contains the Bases for Chapters 2.0 and 3.0, and Sections 3.1--3.3 of the improved STS. Volume 3 contains the Bases for Sections 3.4--3.9 of the improved STS.

  4. Standard technical specifications: Babcock and Wilcox Plants. Revision 1

    International Nuclear Information System (INIS)

    1995-04-01

    This report documents the results of the combined effort of the NRC and the industry to produce improved Standard Technical Specifications (STS), Revision 1 for Babcock ampersand Wilcox Plants. The changes reflected in Revision 1 resulted from the experience gained from license amendment applications to convert to these improved STS or to adopt partial improvements to existing technical specifications. This NUREG is the result of extensive public technical meetings and discussions between the Nuclear Regulatory Commission (NRC) staff and various nuclear power plant licensees, Nuclear Steam Supply System (NSSS) Owners Groups, NSSS vendors, and the Nuclear Energy Institute (NEI). The improved STS were developed based on the criteria in the Final Commission Policy Statement on Technical Specifications Improvements for Nuclear Power Reactors, dated July 22, 1993. The improved STS will be used as the basis for individual nuclear power plant licensees to develop improved plant-specific technical specifications. This report contains three volumes. Volume 1 contains the Specifications for all chapters and sections of the improved STS. Volume 2 contains the Bases for Chapters 2.0 and 3.0, and Sections 3.1--3.3 of the improved STS. Volume 3 contains the Bases for Sections 3.4--3.9 of the improved STS

  5. Technical specification optimization program - engineered safety features

    International Nuclear Information System (INIS)

    Andre, G.R.; Jansen, R.L.

    1986-01-01

    The Westinghouse Technical Specification Program (TOP) was designed to evaluate on a quantitative basis revisions to Nuclear Power Plant Technical Specifications. The revisions are directed at simplifying plant operation, and reducing unnecessary transients, shutdowns, and manpower requirements. In conjunction with the Westinghouse Owners Group, Westinghouse initiated a program to develop a methodology to justify Technical Specification revisions; particularly revisions related to testing and maintenance requirements on plant operation for instrumentation systems. The methodology was originally developed and applied to the reactor trip features of the reactor protection system (RPS). The current study further refined the methodology and applied it to the engineered safety features of the RPS

  6. Technical specification for vacuum systems

    International Nuclear Information System (INIS)

    Khaw, J.

    1987-01-01

    The vacuum systems at the Stanford Linear Accelerator Center (SLAC) are primarily of all-metal construction and operate at pressures from 10 -5 to 10 -11 Torr. The primary gas loads during operation result from thermal desorption and beam-induced desorption from the vacuum chamber walls. These desorption rates can be extremely high in the case of hydrocarbons and other contaminants. These specifications place a major emphasis on eliminating contamination sources. The specifications and procedures have been written to insure the cleanliness and vacuum integrity of all SLAC vacuum systems, and to assist personnel involved with SLAC vacuum systems in choosing and designing components that are compatible with existing systems and meet the quality and reliability of SLAC vacuum standards. The specification includes requirements on design, procurement, fabrication, chemical cleaning, clean room practices, welding and brazing, helium leak testing, residual gas analyzer testing, bakeout, venting, and pumpdown. Also appended are specifications regarding acceptable vendors, isopropyl alcohol, bakeable valve cleaning procedure, mechanical engineering safety inspection, notes on synchrotron radiation, and specifications of numerous individual components

  7. Technical specification for vacuum systems

    Energy Technology Data Exchange (ETDEWEB)

    Khaw, J. (ed.)

    1987-01-01

    The vacuum systems at the Stanford Linear Accelerator Center (SLAC) are primarily of all-metal construction and operate at pressures from 10/sup -5/ to 10/sup -11/ Torr. The primary gas loads during operation result from thermal desorption and beam-induced desorption from the vacuum chamber walls. These desorption rates can be extremely high in the case of hydrocarbons and other contaminants. These specifications place a major emphasis on eliminating contamination sources. The specifications and procedures have been written to insure the cleanliness and vacuum integrity of all SLAC vacuum systems, and to assist personnel involved with SLAC vacuum systems in choosing and designing components that are compatible with existing systems and meet the quality and reliability of SLAC vacuum standards. The specification includes requirements on design, procurement, fabrication, chemical cleaning, clean room practices, welding and brazing, helium leak testing, residual gas analyzer testing, bakeout, venting, and pumpdown. Also appended are specifications regarding acceptable vendors, isopropyl alcohol, bakeable valve cleaning procedure, mechanical engineering safety inspection, notes on synchrotron radiation, and specifications of numerous individual components. (LEW)

  8. Technical Specification action statements requiring shutdown

    International Nuclear Information System (INIS)

    Mankamo, T.; Kim, I.S.; Samanta, P.K.

    1993-11-01

    When safety systems fail during power operation, the limiting conditions for operation (LCOs) and associated action statements of technical specifications typically require that the plant be shut down within the limits of allowed outage time (AOT). However, when a system needed to remove decay heat, such as the residual heat removal (RHR) system, is inoperable or degraded, shutting down the plant may not necessarily be preferable, from a risk perspective, to continuing power operation over a usual repair time, giving priority to the repairs. The risk impact of the basic operational alternatives, i.e., continued operation or shutdown, was evaluated for failures in the RHR and standby service water (SSW) systems of a boiling-water reactor (BWR) nuclear power plant. A complete or partial failure of the SSW system fails or degrades not only the RHR system but other front-line safety systems supported by the SSW system. This report presents the methodology to evaluate the risk impact of LCOs and associated AOT; the results of risk evaluation from its application to the RHR and SSW systems of a BWR; the findings from the risk-sensitivity analyses to identify alternative operational policies; and the major insights and recommendations to improve the technical specifications action statements

  9. Technical requirements specification for tank waste retrieval

    Energy Technology Data Exchange (ETDEWEB)

    Lamberd, D.L.

    1996-09-26

    This document provides the technical requirements specification for the retrieval of waste from the underground storage tanks at the Hanford Site. All activities covered by this scope are conducted in support of the Tank Waste Remediation System (TWRS) mission.

  10. Technical specifications: Health Physics Research Reactor

    International Nuclear Information System (INIS)

    1986-03-01

    These technical specifications define the key limitations that must be observed for safe operation of the Health Physics Research Reactor (HPRR) and an envelope of operation within which there is assurance that these limits will not be exceeded

  11. Technical specifications for the bulk shielding reactor

    International Nuclear Information System (INIS)

    1986-05-01

    This report provides information concerning the technical specifications for the Bulk Shielding Reactor. Areas covered include: safety limits and limiting safety settings; limiting conditions for operation; surveillance requirements; design features; administrative controls; and monitoring of airborne effluents. 10 refs

  12. Procedures for evaluating technical specifications (PETS)

    International Nuclear Information System (INIS)

    Samanta, P.K.; Boccio, J.L.; Vesely, W.E.

    1987-01-01

    In this paper, aspects of technical specifications relating to Generic Issues B-56 and B-61 are discussed from a risk-standpoint. These primarily deal with the risk issues associated with (1) adaptive diesel test requirements/surveillance test intervals, and (2) the effectiveness of cumulative outage time requirements for controlling downtime risk. Risk and reliability approaches are presented which (1) allow risk-acceptable test intervals to be determined for any diesel and (2) show the potential risk-control capability of prescribed allowed cumulative outage times. This work was conducted through NRC's Procedures for Evaluating Technical Specifications (PETS) Program. The overall objective of this program is to develop and demonstrate methodologies that utilize risk insights and reliability techniques for evaluating the scope, detailed requirements, and safety impact of plant technical specifications

  13. Technical specifications for PWR secondary water chemistry

    International Nuclear Information System (INIS)

    Weeks, J.R.; van Rooyen, D.

    1977-08-01

    The bases for establishing Technical Specifications for PWR secondary water chemistry are reviewed. Whereas extremely stringent control of secondary water needs to be maintained to prevent denting in some units, sound bases for establishing limits that will prevent stress corrosion, wastage, and denting do not exist at the present time. This area is being examined very thoroughly by industry-sponsored research programs. Based on the evidence available to date, short term control limits are suggested; establishment of these or other limits as Technical Specifications is not recommended until the results of the research programs have been obtained and evaluated

  14. Standard Technical Specifications, General Electric plants, BWR/4

    International Nuclear Information System (INIS)

    1992-09-01

    This NUREG contains improved Standard Technical Specifications (STS) for General Electric Plants, BWR/6, and documents the positions of the Nuclear Regulatory Commission based on the B ampersand W Owners Group's proposed STS. This document is the result of extensive technical meetings and discussions among the NRC staff, the Nuclear Steam Supply System (NSSS) Owners Groups, the NSSS vendors, and the Nuclear Management and Resources Council (NUMARC). The improved STS were developed based on the criteria in the interim Commission Policy Statement on Technical Specification Improvements for Nuclear Power Reactors, dated February 6, 1987. The improved STS will be used as the basis for individual nuclear power plant licensees to develop improved plant-specific technical specifications. This report contains three volumes. Volume 1 contains the Specifications for all chapters and sections of the improved STS. Volume 2 contains the Bases for Chapters 2.0 and 3.0, and Sections 3.1--3.3 of the improved STS. This document Volume 3, contains the Bases for Sections 3.4--3.10 of the improved STS

  15. Standard Technical Specifications, General Electric Plants, BWR/6

    International Nuclear Information System (INIS)

    1992-09-01

    This NUREG contains improved Standard Technical Specifications (STS) for General Electric Plants, BWR/6, and documents the positions of the Nuclear Regulatory Commission based on the B ampersand W Owners Group's proposed STS. This document is the result of extensive technical meetings and discussions among the NRC staff, the Nuclear Steam Supply System (NSSS) Owners Groups, the NSSS vendors, and the Nuclear Management and Resources Council (NUMARC). The improved STS were developed based on the criteria in the interim Commission Policy Statement on Technical Specification Improvements for Nuclear Power Reactors, dated February 6, 1987. The improved STS will be used as the basis for individual nuclear power plant licensees to develop improved plant-specific technical specifications. This report contains three volumes. This document Volume 1, contains the Specifications for all chapters and sections of the improved STS. Volume 2 contains the Bases for Chapters 2.0 and 3.0, and Sections 3.1--3.3 of the improved STS. Volume 3 contains the Bases for Sections 3.4--3.10 of the improved STS

  16. Standard Technical Specifications, General Electric plants, BWR/4

    International Nuclear Information System (INIS)

    1992-09-01

    This NUREG contains improved Standard Technical Specifications (STS) for General Electric Plants, BWR/6, and documents the positions of the Nuclear Regulatory Commission based on the BWR Owners Group's proposed STS. This document is the result of extensive technical meetings and discussions among the NRC staff, the Nuclear Steam Supply System (NSSS) Owners Groups, the NSSS vendors, and the Nuclear Management and Resources Council (NUMARC). The improved STS were developed based on the criteria in the interim Commission Policy Statement on Technical Specification Improvements for Nuclear Power Reactors, dated February 6, 1987. The improved STS will be used as the basis for individual nuclear power plant licensees to develop improved plant-specific technical specifications. This report contains three volumes. This document Volume 1 contains the Specifications for all chapters and sections of the improved STS. Volume 2 contains the Bases for Chapters 2.0 and 3.0, and Sections 3.1--3.3 of the improved STS. Volume 3 contains the Bases for Sections 3.4--3.10 of the improved STS

  17. Risk-based technical specifications program: Site interview results

    International Nuclear Information System (INIS)

    Andre, G.R.; Baker, A.J.; Johnson, R.L.

    1991-08-01

    The Electric Power Research Institute and Pacific Gas and Electric Company are sponsoring a program directed at improving Technical Specifications using risk-based methods. The major objectives of the program are to develop risk-based approaches to improve Technical Specifications and to develop an Interactive Risk Advisor (IRA) prototype. The IRA is envisioned as an interactive system that is available to plant personnel to assist in controlling plant operation. Use of an IRA is viewed as a method to improve plant availability while maintaining or improving plant safety. In support of the program, interviews were conducted at several PWR and BWR plant sites, to elicit opinions and information concerning risk-based approaches to Technical Specifications and IRA requirements. This report presents the results of these interviews, including the functional requirements of an IRA. 2 refs., 6 figs., 2 tabs

  18. Standard technical specifications: Combustion engineering plants. Volume 1, Revision 1: Specifications

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-04-01

    This report documents the results of the combined effort of the NRC and the industry to produce improved Standard Technical Specifications (STS), Revision 1 for Combustion Engineering Plants. The changes reflected in Revision 1 resulted from the experience gained from license amendment applications to convert to these improved STS or to adopt partial improvements to existing technical specifications. This NUREG is the result of extensive public technical meetings and discussions between the Nuclear Regulatory Commission (NRC) staff and various nuclear power plant licensees, Nuclear Steam Supply System (NSSS) Owners Groups, NSSS vendors, and the Nuclear Energy Institute (NEI). The improved STS were developed based on the criteria in the Final Commission Policy Statement on Technical Specifications Improvements for Nuclear Power Reactors, dated July 22, 1993. The improved STS will be used as the basis for individual nuclear power plant licensees to develop improved plant-specific technical specifications. This report contains three volumes. Volume 1 contains the Specifications for all chapters and sections of the improved STS. Volume 2 contains the Bases for Chapters 2.0 and 3.0, and Sections 3.1--3.3 of the improved STS. Volume 3 contains the Bases for Sections 3.4--3.9 of the improved STS.

  19. Standard technical specifications: General Electric plants, BWR/4. Volume 1, Revision 1: Specifications

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-04-01

    This report documents the results of the combined effort of the NRC and the industry to produce improved Standard Technical Specifications (STS), Revision 1 for General Electric BWR/4 Plants. The changes reflected in Revision 1 resulted from the experience gained from license amendment applications to convert to these improved STS or to adopt partial improvements to existing technical specifications. This NUREG is the result of extensive public technical meetings and discussions between the Nuclear Regulatory Commission (NRC) staff and various nuclear power plant licensees, Nuclear Steam Supply System (NSSS) Owners Groups, NSSS vendors, and the Nuclear Energy Institute (NEI). The improved STS were developed based on the criteria in the Final Commission Policy Statement on Technical Specifications Improvements for Nuclear Power Reactors, dated July 22, 1993. The improved STS will be used as the basis for individual nuclear power plant licensees to develop improved plant-specific technical specifications. This report contains three volumes. Volume 1 contains the Specifications for all chapters and sections of the improved STS. Volume 2 contains the Bases for Chapters 2.0 and 3.0, and Sections 3.1--3.3 of the improved STS. Volume 3 contains the Bases for Sections 3.4--3.10 of the improved STS.

  20. Risk management through dynamic technical specifications

    International Nuclear Information System (INIS)

    Klopp, George T.; Petersen, Thomas A.

    2004-01-01

    The wide deployment of plant specific probabilistic risk assessments for nuclear power plants has provided the means to effect a fresh risk management perspective and a fresh, risk based, regulatory outlook on nuclear power. There has been a great deal of conversation on risk based regulation within the U. S. nuclear power industry but, curiously, very little on effective risk management. This paper proposes a means to link the two subjects through the plant Technical Specifications. A revised concept for Technical Specifications is suggested which is based on deterministic analyses and probabilistic risk assessments for each plant. The revised Technical Specifications would consider, on a real-time basis, the exact state of the plant in terms of the status of key components and systems. It would depict current plant risk levels and compare those levels to the desired and limiting (alert/action) levels. It would advise the plant operator on the risk impact of proposed actions through a simple query system and illustrate the impact of such actions on plant status relative to designated risk values. The basis for the proposed approach lies in realistic deterministic plant analyses and probabilistic risk assessment (PRA) deployment tools being developed, in parallel, by a number of parties in the U.S. today. These PRAs are based primarily on the existing plant responses to Generic Letter 88-20, 'Individual Plant Examinations' (IPEs). Each of these tools allows the plant operator to input, on a real-time basis, the status of key equipment and systems. The tools then provide explicit illustrations of dependency effects; updated, 'real-time' risk status indications such as core damage frequency; and, in some cases, allow the operator to assess the risk impact of removing from service selected components for maintenance or testing. These systems generally operate on personal computers and provide nearly instantaneous responses to plant queries. Moving from these tools to

  1. Technical specifications report. Auditing and financial system

    Energy Technology Data Exchange (ETDEWEB)

    Feldmiller, W.H.

    1980-01-01

    The U.S. Geological Survey's Conservation Division is responsible for regulating the development of mineral resources on Federal leased lands and Indian reservations and for collecting the rents and royalties due from these lands. The objective of the Division is to reduce the regulatory burden on industry while effectively and efficiently discharging its responsibility. The development of the Improved Royalty Management Program (IRMP) is a major step in accomplishing these goals. The completion of the technical design of the first phase in the development of the IRMP is reported. How the Auditing and Financial System (AFS) will operate from a data-processing viewpoint is described, as well as how the system will perform the functions identified in the AFS Functional Specifications Report. Information is provided on the following: Systems Components (hardware, software, organizations, and security; Data Base Design; Overall System Flow; Batch Processes; On-line Processes; System Testing; Conversion; and Resource Requirements (performance, computer storage; timings, terminals, transmission, datapoint configuration; personnel).

  2. Technical specifications for the Pajarito Site Critical Experiments Facility

    International Nuclear Information System (INIS)

    Malenfant, R.E.; Paxton, H.C.

    1980-12-01

    This document is to satisfy the requirement for technical specifications spelled out in DOE Manual Chapter 0540, Safety of DOE-Owned Reactors. Technical specifications are defined in Sec. 0540-048, and the requirement for them appears in Sec. 0540-015. The following technical specifications update the document, Technical Specifications for the Pajarito Site Critical Experiments Facility

  3. Operating experience feedback report: Technical specifications: Commercial power reactors

    International Nuclear Information System (INIS)

    O'Reilly, P.D.; Plumlee, G.L. III.

    1989-03-01

    This report documents a trends and patterns analysis of technical specification (TS)-related licensee event reports (LERs) conducted by the Nuclear Regulatory Commission's (NRC's) Office for Analysis and Evaluation of Operational Data (AEOD). The objectives of this analysis were (1) to identify and catalog technical specification-related LERs, (2) to categorize and evaluate the events reported in these a LERs, (3) to identify any issues arising from the evaluation which appear to have generic safety significance, or which relate to the on-going Technical Specification Improvement Program, and (4) to trend the results obtained from the analysis of the data obtained in (1) through (3). 9 refs., 9 figs., 22 tabs

  4. Optimisation of technical specifications using probabilistic methods

    International Nuclear Information System (INIS)

    Ericsson, G.; Knochenhauer, M.; Hultqvist, G.

    1986-01-01

    During the last few years the development of methods for modifying and optimising nuclear power plant Technical Specifications (TS) for plant operations has received increased attention. Probalistic methods in general, and the plant and system models of probabilistic safety assessment (PSA) in particular, seem to provide the most forceful tools for optimisation. This paper first gives some general comments on optimisation, identifying important parameters and then gives a description of recent Swedish experiences from the use of nuclear power plant PSA models and results for TS optimisation

  5. Risk-informed approach in US-APWR technical specifications

    International Nuclear Information System (INIS)

    Saji, Etsuro; Tanaka, Futoshi; Kuroiwa, Katsuya; Kawai, Katsunori

    2009-01-01

    The Risk-Managed Technical Specifications and the Surveillance Frequency Control Program have been adopted in the US-APWR Technical Specifications. These risk-informed approaches are unique among the technical specifications for the advanced light water reactor designs adopted by planned nuclear power stations in the United States. (author)

  6. Technical Submission Form: Technical Specification of a Wave Energy Farm.

    Energy Technology Data Exchange (ETDEWEB)

    Roberts, Jesse D.; Kim Nielsen; Ben Kennedy; Bull, Diana L; Costello, Ronan Patrick; Jochem Weber

    2017-04-01

    The Wave - SPARC project developed the Technology Performance Level (TPL) assessment procedure based on a rigorous Systems Engineering exercise. The TPL assessment allows a whole system evaluation of Wave Energy Conversion Technology by measuring it against the requirements determined through the Systems Engineering exercise. The TPL assessment is intended to be useful in technology evaluation; in technology innovation; in allocation of public or priva te investment, and; in making equipment purchasing decisions. This Technical Submission Form (TSF) serves the purpose of collecting relevant and complete information, in a technology agnostic way, to allow TPL assessment s to be made by third party assessor s. The intended usage of this document is that the organization or people that are performing the role of developers or promoters of a particular technology will use this form to provide the information necessary for the organization or people who are perf orming the assessor role to use the TPL assessment.

  7. Feasibility assessment of a risk-based approach to technical specifications

    International Nuclear Information System (INIS)

    Atefi, B.; Gallagher, D.W.

    1991-05-01

    To assess the potential use of risk and reliability techniques for improving the effectiveness of the technical specifications to control plant operational risk, the Technical Specifications Branch of the Nuclear Regulatory Commission initiated an effort to identify and evaluate alternative risk-based approaches that could bring greater risk perspective to these requirements. In the first phase four alternative approaches were identified and their characteristics were analyzed. Among these, the risk-based approach to technical specifications is the most promising approach for controlling plant operational risk using technical specifications. The second phase of the study concentrated on detailed characteristics of the real time risk-based approach. It is concluded that a real time risk-based approach to technical specifications has the potential to improve both plant safety and availability. 33 figs., 5 figs., 6 tabs

  8. A study on decision-making framework for developing risk-informed technical specifications

    International Nuclear Information System (INIS)

    Kim, Beom Seock

    2002-02-01

    The utility and the nuclear research institutes in Korea have conduct research for improving inefficient requirements in technical specifications using the results of probability risk assessments and information associated with risk. However, the guidance for reviewing the improved technical specifications has not been developed. Thus, the objective of this study is to develop a decision-making framework for investigating and reviewing the documents associated with the changes of technical specifications. This work has been done for helping the regulation agency to review the improved technical specifications as well as to make decisions whether the remedy is accepted or not. The contents of this study include: 1. Surveys on Technical Specification regulations in foreign countries as well as those in Korea 2. Surveys on the state- of- the- art methodology for Risk Informed Technical Specifications and their uses in Korea 3. Development of a decision-making framework in both the licensee and the regulation agency position 4. Development and applications of a decision-making framework using Influence Diagrams. The decision-making framework for RITS using Influence Diagrams are developed and applied to an example problem in this study. This work might contribute to developing the risk informed regulation guidance for improving the quality of the current technical specifications

  9. Standard technical specifications General Electric plants, BWR/6. Volume 1, Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-04-01

    This report documents the results of the combined effort of the NRC and the industry to produce improved Standard Technical Specifications (STS), Revision 1 for General Electric BWR/6 Plants. The changes reflected in Revision 1 resulted from the experience gained from license amendment applications to convert to these improved STS or to adopt partial improvements to existing technical specifications. This NUREG is the result of extensive public technical meetings and discussions between the Nuclear Regulatory Commission (NRC) staff and various nuclear power plant licensees, Nuclear Steam Supply System (NSSS) Owners Groups, NSSS vendors, and the Nuclear Energy Institute (NEI). The improved STS were developed based on the criteria in the Final Commission Policy Statement on Technical Specifications Improvements for Nuclear Power Reactors, dated July 22, 1993. The improved STS will be used as the basis for individual nuclear power plant licensees to develop improved plant-specific technical specifications. This report contains three volumes. Volume 1 contains the Specifications for all chapters and sections of the improved STS. Volume 2 contains the Bases for Chapters 2.0 and 3.0, and Sections 3.1--3.3 of the improved STS. Volume 3 contains the Bases for Sections 3.4--3.10 of the improved STS.

  10. HFBR: Review of the technical specifications against the FSAR

    International Nuclear Information System (INIS)

    Rao, D.V.; Boss, S.B.; Claiborne, E.R.; Darby, J.L.; Clark, R.A.

    1990-01-01

    The purpose of this review is to determine the adequacy of the High Flux Beam Reactor (HFBR) Technical Specifications for 40 MW operation by comparison with the HFBR Final Safety Analysis Report, particularly the accident analyses chapter. Specifically, the Technical Specifications were compared against the Design Basis Accident (DBA) Analyses presented in the Addendum to the HFBR FSAR for 60 MW Operation. The 60 MW DBA analyses was used since it is more current and complete than the analyses presented in the original FSAR which is considered obsolete. A listing of the required systems and equipment was made for each of the accidents analyzed. Additionally, the Technical Specification instrument setpoints were compared to the DBA analyses parametric values. Also included in this review was a comparison of the Technical Specification Bases against the FSAR and the identification of any differences. The HFBR Operations Procedures Manual (OPM) was also reviewed for any inconsistencies between the FSAR or the Technical Specifications. Upon completion of this review it was determined that the Technical Specifications are well written and the items commented on should not delay the low power restart (40 MW). Additionally, the OPM is also well written and does not require further modification before restart

  11. Preparation of radiological effluent technical specifications for nuclear power plants. a guidance manual for users of standard technical specifications

    International Nuclear Information System (INIS)

    Boegli, J.S.; Bellamy, R.R.; Britz, W.L.; Waterfield, R.L.

    1978-10-01

    The purpose of this manual is to describe methods found acceptable to the staff of the U.S. Nuclear Regulatory Commission (NRC) for the calculation of certain key values required in the preparation of proposed radiological effluent Technical Specifications using the Standard Technical Specifications for light-water-cooled nuclear power plants. This manual also provides guidance to applicants for operating licenses for nuclear power plants in the preparation of proposed radiological effluent Technical Specifications or in preparing requests for changes to existing radiological effluent Technical Specifications for operating licenses. The manual additionally describes current staff positions on the methodology for estimating radiation exposure due to the release of radioactive materials in effluents and on the administrative control of radioactive waste treatment systems

  12. Preparation of radiological effluent technical specifications for nuclear power plants. a guidance manual for users of standard technical specifications

    Energy Technology Data Exchange (ETDEWEB)

    Boegli, J.S.; Bellamy, R.R.; Britz, W.L.; Waterfield, R.L. (eds.)

    1978-10-01

    The purpose of this manual is to describe methods found acceptable to the staff of the U.S. Nuclear Regulatory Commission (NRC) for the calculation of certain key values required in the preparation of proposed radiological effluent Technical Specifications using the Standard Technical Specifications for light-water-cooled nuclear power plants. This manual also provides guidance to applicants for operating licenses for nuclear power plants in the preparation of proposed radiological effluent Technical Specifications or in preparing requests for changes to existing radiological effluent Technical Specifications for operating licenses. The manual additionally describes current staff positions on the methodology for estimating radiation exposure due to the release of radioactive materials in effluents and on the administrative control of radioactive waste treatment systems.

  13. Standard technical specifications combustion engineering plants: Bases (Sections 2.0--3.3). Volume 2, Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-04-01

    This report documents the results of the combined effort of the NRC and the industry to produce improved Standard Technical Specifications (STS), Revision 1 for General Electric BWR/6 Plants. The changes reflected in Revision 1 resulted from the experience gained from license amendment applications to convert to these improved STS or to adopt partial improvements to existing technical specifications. This NUREG is the result of extensive public technical meetings and discussions between the Nuclear Regulatory Commission (NRC) staff and various nuclear power plant licensees, Nuclear Steam Supply System (NSSS) Owners Groups, NSSS vendors, and the Nuclear Energy Institute (NEI). The improved STS were developed based on the criteria in the Final Commission Policy Statement on Technical Specifications Improvements for Nuclear Power Reactors, dated July 22, 1993. The improved STS will be used as the basis for individual nuclear power plant licensees to develop improved plant-specific technical specifications. This report contains three volumes.

  14. Improving Technical Instruction Using Personality Styles.

    Science.gov (United States)

    Tomal, Daniel R.

    2003-01-01

    Incorporating personality styles into technical instruction can enhance student learning. Four personality styles based on Jung--intuitor, feeler, thinker, and doer--have implications for individualizing technical instruction. (JOW)

  15. Methodology for risk-based analysis of technical specifications

    International Nuclear Information System (INIS)

    Vesely, W.E.; Gaertner, J.P.; Wagner, D.P.

    1985-01-01

    Part of the effort by EPRI to apply probabilistic risk assessment methods and results to the solution of utility problems involves the investigation of methods for risk-based analysis of technical specifications. The culmination of this investigation is the SOCRATES computer code developed by Battelle's Columbus Laboratories to assist in the evaluation of technical specifications of nuclear power plants. The program is designed to use information found in PRAs to re-evaluate risk for changes in component allowed outage times (AOTs) and surveillance test intervals (STIs). The SOCRATES program is a unique and important tool for technical specification evaluations. The detailed component unavailability model allows a detailed analysis of AOT and STI contributions to risk. Explicit equations allow fast and inexpensive calculations. Because the code is designed to accept ranges of parameters and to save results of calculations that do not change during the analysis, sensitivity studies are efficiently performed and results are clearly displayed

  16. Feasibility assessment of a risk-based approach to technical specifications

    International Nuclear Information System (INIS)

    Atefi, B.; Gallagher, D.W.

    1991-05-01

    The first phase of the assessment concentrates on (1) identification of selected risk-based approaches for improving current technical specifications, (2) appraisal of characteristics of each approach, including advantages and disadvantages, and (3) recommendation of one or more approaches that might result in improving current technical specification requirements. The second phase of the work concentrates on assessment of the feasibility of implementation of a pilot program to study detailed characteristics of the preferred approach. The real time risk-based approach was identified as the preferred approach to technical specifications for controlling plant operational risk. There do not appear to be any technical or institutional obstacles to prevent initiation of a pilot program to assess the characteristics and effectiveness of such an approach. 2 tabs

  17. 33 CFR 157.12d - Technical specifications.

    Science.gov (United States)

    2010-07-01

    ... must be designed so a discharge of dirty-ballast or other oil-contaminated water from the cargo tank...) POLLUTION RULES FOR THE PROTECTION OF THE MARINE ENVIRONMENT RELATING TO TANK VESSELS CARRYING OIL IN BULK Design, Equipment, and Installation § 157.12d Technical specifications. (a) Oil discharge monitoring and...

  18. Standard technical specifications for General Electric boiling water reactors

    International Nuclear Information System (INIS)

    1979-08-01

    This Standard Technical Specification (STS) has been structured for the broadest possible use on General Electric plants currently being reviewed for an Operating License. Optional specifications are provided for those features and systems which may be included in individual plant designs but are not generic in their scope of application. This revision of the GE-STS does not typically include requirements which may be added or revised as a result of the NRC staff's further review of the Three Mile Island incident

  19. Improving Technical, Tactical and Psychological Preparation of Freestyle Wrestlers

    Directory of Open Access Journals (Sweden)

    Pakulin Serhij

    2016-12-01

    Full Text Available Objectives: 1 to justify the ways of improvement of training free style wrestlers to improve the results of their activities and competitive sports skills; 2 to identify the areas of improvement of psychological preparation and the structure of complex psycho-pedagogical methods for optimizing mental condition of free style wrestlers. Material and methods: The following methods were used in the study: analysis and synthesis of the scientific data of methodological literature; pedagogical supervision; survey (interview, questionnaire; analysis of freestyle wrestlers competitive activity; testing of physical and psychological fitness; pedagogical experiment; methods of mathematical and statistical analysis of research results. Results: it has been demonstrated that there is a necessity to improve technical, tactical and psychological preparation of freestyle fighters; the basic problems of the process have been defined. Conclusion: 1 the method of preparation of freestyle wrestlers has been grounded and the feasibility of its use for rapid making the best technical and tactical decisions in a competitive activity has been proved. It is proposed to include specific tactical training methods for each action and various combinations of basic actions into the coach program of wrestling; 2 the directions of improving psychological preparation and the structure of complex psychological and pedagogical methods of optimizing the mental condition of free style wrestlers are substantiated.

  20. Technical specifications for mechanical recycling of agricultural plastic waste.

    Science.gov (United States)

    Briassoulis, D; Hiskakis, M; Babou, E

    2013-06-01

    Technical specifications appropriate for the recycling of agricultural plastic wastes (APWs), widely accepted by the recycling industry were developed. The specifications establish quality standards to be met by the agricultural plastics producers, users and the agricultural plastic waste management chain. They constitute the base for the best economical and environmental valorisation of the APW. The analysis of the APW streams conducted across Europe in the framework of the European project "LabelAgriWaste" revealed the inherent characteristics of the APW streams and the inherent constraints (technical or economical) of the APW. The APW stream properties related to its recycling potential and measured during pilot trials are presented and a subsequent universally accepted simplified and expanded list of APW recycling technical specifications is proposed and justified. The list includes two sets of specifications, applied to two different quality categories of recyclable APW: one for pellet production process ("Quality I") and another one for plastic profile production process ("Quality II"). Parameters that are taken into consideration in the specifications include the APW physical characteristics, contamination, composition and degradation. The proposed specifications are focused on polyethylene based APW that represents the vast majority of the APW stream. However, the specifications can be adjusted to cover also APW of different materials (e.g. PP or PVC) that are found in very small quantities in protected cultivations in Europe. The adoption of the proposed specifications could transform this waste stream into a labelled commodity traded freely in the market and will constitute the base for the best economical and environmental valorisation of the APW. Copyright © 2013 Elsevier Ltd. All rights reserved.

  1. Standard technical specifications for Westinghouse pressurized water reactors

    International Nuclear Information System (INIS)

    Wagner, P.C.

    1979-07-01

    This Standard Technical Specification (STS) has been structured for the broadest possible use on Westinghouse plants currently being reviewed for an Operating License. Accordingly, the document contains specifications applicable to plants with (1) either 3 or 4 loops and (2) with and without loop stop valves. In addition, four separate and discrete containment specification sections are provided for each of the following containment types: Atmospheric, Ice Condenser, Sub-Atmospheric, and Dual. Optional specifications are provided for those features and systems which may be included in individual plant designs but are not generic in their scope of application. Alternate specifications are provided in a limited number of cases to cover situations where alternate specification requirements are necessary on a generic basis because of design differences. This revision of the STS does not typically include requirements which may be added or revised as a result of the NRC staff's further review of the Three Mile Island incident

  2. Savannah River Site production reactor technical specifications. K Production Reactor

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-02-01

    These technical specifications are explicit restrictions on the operation of the Savannah River Site K Production Reactor. They are designed to preserve the validity of the plant safety analysis by ensuring that the plant is operated within the required conditions bounded by the analysis, and with the operable equipment that is assumed to mitigate the consequences of an accident. Technical specifications preserve the primary success path relied upon to detect and respond to accidents. This report describes requirements on thermal-hydraulic limits; limiting conditions for operation and surveillance for the reactor, power distribution control, instrumentation, process water system, emergency cooling and emergency shutdown systems, confinement systems, plant systems, electrical systems, components handling, and special test exceptions; design features; and administrative controls.

  3. USER SPECIFICATIONS FOR PRESSURE VESSELS AND TECHNICAL INTEGRITY

    Directory of Open Access Journals (Sweden)

    K.S. Johnston

    2012-01-01

    Full Text Available

    ENGLISH ABSTRACT: Specifications translated from user requirements are prescribed in an attempt to capture and incorporate best practices with regards to the design, fabrication, testing, and operation of pressure vessels. The question as to whether these requirements affect the technical integrity of pressure vessels is often a subjective matter. This paper examines typical user requirement specifications against technical integrity of pressure vessels.
    The paper draws on a survey of a convenience sample of practising engineers in a diversified petrochemical company. When compared with failures on selected pressure vessels recorded by Phillips and Warwick, the respondent feedback confirms the user specifications that have the highest impact on technical integrity.

    AFRIKAANSE OPSOMMING: Gebruikersbehoeftes word saamgevat in spesifikasies wat lei tot goeie praktyk vir ontwerp, vervaarding, toetsing en bedryf van drukvate. Subjektiwiteit van die gebruikersbehoeftes mag soms die tegniese integriteit van ‘n drukvat beinvloed.
    Die navorsing maak by wyse van monsterneming gebruik van die kennis van ingenieurs wat werk in ‘n gediversifiseerde petrochemiese bedryf. Die terugvoering bevestig dat bogenoemde spesifikasies inderdaad die grootste invloed het op tegniese integriteit.

  4. Standard technical specifications for Babcock and Wilcox pressurized water reactors

    International Nuclear Information System (INIS)

    1978-06-01

    The Standard Technical Specification (STS) has been structured for the broadest possible use on B and W NSSS plants currently being reviewed for an Operating License. Two separate and discrete containment specification sections are provided for each of the following containment types: Atmospheric, and Dual. Optional specifications are provided for those features and systems which may be included in individual plant designs but are not generic in their scope of application. Alternate specifications are provided in a limited number of cases to cover situations where alternate specification requirements are necessary on a generic basis because of design differences. The format of the STS addresses the categories required by 10 CFR 50 and consists of six sections covering the areas of: Definitions, Safety Limits and Limiting Safety System Settings, Limiting Conditions for Operation, Surveillance Requirements, Design Features, and Administrative Controls

  5. Standard technical specifications for Babcock and Wilcox pressurized water reactors

    International Nuclear Information System (INIS)

    Virgilio, M.

    1979-07-01

    This Standard Technical Specification (STS) has been structured for the broadest possible use on B and W NSSS plants currently being reviewed for an Operating License. Two separate and discrete containment specification sections are provided for each of the following containment types: Atmospheric and Dual. Optional specifications are provided for those features and systems which may be included in individual plant designs but are not generic in their scope of application. Alternate specifications are provided in a limited number of cases to cover situations where alternate specification requirements are necessary on a generic basis because of design differences. This revision of STS does not typically include requirements which may be added or revised as a result of the NRC staff's further review of the Three Mile Island incident

  6. Technical and quality assurance specifications for dosimetry services

    International Nuclear Information System (INIS)

    1989-01-01

    The Canadian Atomic Energy Control Board (AECB) requires its licensees to establish a program to determine or estimate the radiation doses received by workers exposed to radiation as a result of the licensee's activities. The determination of radiation dose is a two-part process. First a measurement is made; then this measurement is used in a dosimetric model to calculate the dose. This document is concerned only with the first step of the process. It gives guidance on the technical specifications for dosimetry services and the quality assurance program that provides confidence that these specifications are achieved. (L.L.)

  7. Optimization of technical specifications by use of probabilistic methods

    International Nuclear Information System (INIS)

    Laakso, K.

    1990-01-01

    The Technical Specifications of a nuclear power plant specify the limits for plant operation from the safety point of view. These operational safety rules were originally defined on the basis of deterministic analyses and engineering judgement. As experience has accumulated, it has proved necessary to consider problems and make specific modifications in these rules. Developments in probabilistic safety assessment have provided a new tool to analyse, present and compare the risk effects of proposed rule modificatons. The main areas covered in the project are operational decisions in failure situations, preventive maintenance during power operation and surveillance tests of standby safety systems. (author)

  8. Improving technical support for vegetable production in Mayotte through the creation of Recommended Technical Itineraries

    OpenAIRE

    Praire, Thomas

    2014-01-01

    The Network for Innovation and Transfer in Agriculture (RITA) of Mayotte is piloting a project on Recommended Technical Itineraries (ITR). The agricultural school of Coconi is the intermediary of the project. The aim of this project, among others, is to improve technical support given to vegetable producers. The vegetable sector of Mayotte is marginal but in constant progress. The producers are seeking technical support but there are only two technicians for the entire island. The creation of...

  9. Risk based optimization of technical specifications for operation of nuclear power plants

    International Nuclear Information System (INIS)

    1993-12-01

    The objective of the report is to present an overview of the risk and reliability based approaches (using a probabilistic safety assessment (PSA)) for improving nuclear power plant technical specifications (TS). In that case, it will provide an information base to the Member States in seeking PSA based applications to enhance the effectiveness of their technical specifications. To achieve this objective, the report discusses the basic objectives and reasons for seeking TS changes, the methods, data requirements and uses of different types of applications, and an overview of different applications that have been completed, including detailed descriptions of selected applications. Refs, figs and tabs

  10. Mental Fatigue Impairs Soccer-Specific Physical and Technical Performance.

    Science.gov (United States)

    Smith, Mitchell R; Coutts, Aaron J; Merlini, Michele; Deprez, Dieter; Lenoir, Matthieu; Marcora, Samuele M

    2016-02-01

    To investigate the effects of mental fatigue on soccer-specific physical and technical performance. This investigation consisted of two separate studies. Study 1 assessed the soccer-specific physical performance of 12 moderately trained soccer players using the Yo-Yo Intermittent Recovery Test, Level 1 (Yo-Yo IR1). Study 2 assessed the soccer-specific technical performance of 14 experienced soccer players using the Loughborough Soccer Passing and Shooting Tests (LSPT, LSST). Each test was performed on two occasions and preceded, in a randomized, counterbalanced order, by 30 min of the Stroop task (mentally fatiguing treatment) or 30 min of reading magazines (control treatment). Subjective ratings of mental fatigue were measured before and after treatment, and mental effort and motivation were measured after treatment. Distance run, heart rate, and ratings of perceived exertion were recorded during the Yo-Yo IR1. LSPT performance time was calculated as original time plus penalty time. LSST performance was assessed using shot speed, shot accuracy, and shot sequence time. Subjective ratings of mental fatigue and effort were higher after the Stroop task in both studies (P soccer-specific running, passing, and shooting performance.

  11. Standard technical specifications for Westinghouse pressurized water reactors (revision issued Fall 1981). Technical report

    International Nuclear Information System (INIS)

    Virgilio, M.J.

    1981-11-01

    The Standard Technical Specifications for Westinghouse Pressurized Water Reactors (W-STS) is a generic document prepared by the U.S. NRC for use in the licensing process of current Westinghouse Pressurized Water Reactors. The W-STS sets forth the Limits, Operating Conditions and other requirements applicable to nuclear reactor facility operation as set forth in Section 50.36 of 10 CFR Part 50 for the protection of the health and safety of the public

  12. Standard technical specifications - Babcock and Wilcox Plants: Bases (Sections 2.0-3.3). Volume 2, Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-04-01

    This NUREG contains the improved Standard Technical Specifications (STS) for Babcock and Wilcox (B&W) plants. Revision 1 incorporates the cumulative changes to Revision 0, which was published in September 1992. The changes reflected in Revision 1 resulted from the experience gained from license amendment applications to convert to these improved STS or to adopt partial improvements to existing technical specifications. This NUREG is the result of extensive public technical meetings and discussions between the Nuclear Regulatory Commission (NRC) staff and various nuclear power plant licensees, Nuclear Steam Supply System (NSSS) Owners Groups, specifically the B&W Owners Group (BWOG), NSSS vendors, and the Nuclear Energy Institute (NEI). The improved STS were developed based on the criteria in the Final Commission Policy Statement on Technical Specifications Improvements for Nuclear Power Reactors, dated July 22, 1993 (58 FR 39132). Licensees are encouraged to upgrade their technical specifications consistent with those criteria and conforming, to the extent practical and consistent with the licensing basis for the facility, to Revision 1 to the improved STS. The Commission continues to place the highest priority on requests for complete conversions to the improved STS. Licensees adopting portions of the improved STS to existing technical specifications should adopt all related requirements, as applicable, to achieve a high degree of standardization and consistency.

  13. Japanese Technical Information: Opportunities To Improve U.S. Access.

    Science.gov (United States)

    Hill, Christopher T.

    This report develops a conceptual framework for considering policy options to improve access to Japanese and other foreign scientific and technical information. The rationales for and against a role for the federal government in accessing foreign technical information are detailed, and the stages in the process of information access are described.…

  14. Use of probabilistic safety assessment to evaluate nuclear power plant technical specifications

    International Nuclear Information System (INIS)

    1991-04-01

    The meeting was organized to promote the use of risk and reliability techniques to improve safety and operational flexibility of nuclear power plants. The 43 participants from 17 countries and IAEA took part in the meeting. The 23 papers which were presented indicated that there was a worldwide recognition that risk and reliability techniques could be a useful tool to optimize technical specification requirements. A separate abstract was prepared for each of these papers. This TECDOC, prepared by the meeting participants, summarizes the insights from the various papers presented and the plenary discussions. It also presents a regulatory perspective for the use of PSA-based Technical Specifications in Member States. Finally, the proposal of a pilot study programme on the use of risk and reliability methods for technical specifications optimization to be undertaken by Member States under the coordination of the IAEA was discussed. Refs, figs and tabs

  15. Standard Technical Specifications for Westinghouse pressurized water reactors

    International Nuclear Information System (INIS)

    Virgilio, M.J.

    1980-09-01

    The Standard Technical Specifications for Westinghouse Pressurized Water Reactors (W-STS) is a generic document prepared by the U.S. NRC for use in the licensing process of current Westinghouse Pressurized Water Reactors. The W-STS sets forth the Limits, Operating Conditions and other requirements applicable to nuclear reactor facility operation as set forth in by Section 50.36 of 10 CFR Part 50 for the protection of the health and safety of the public. This document is revised periodically to reflect current licensing requirements

  16. Standard Technical Specifications for Combustion Engineering Pressurized Water Reactors

    International Nuclear Information System (INIS)

    Vito, D.J.

    1980-12-01

    The Standard Technical Specifications for Combustion Engineering Pressurized Water Reactors (CE-STS) is a generic document prepared by the US NRC for use in the licensing process of current Combustion Engineering Pressurized Water Reactors. The CE-STS sets forth the limits, operating conditions, and other requirements applicable to nuclear reactor facility operation as set forth by Section 50.36 of 10 CFR 50 for the protection of the health and safety of the public. The document is revised periodically to reflect current licensing requirements

  17. Standard Technical Specifications General Electric plants, BWR/4:Bases (Sections 3.4-3.10). Volume 3, Revision 1

    International Nuclear Information System (INIS)

    1995-04-01

    This report documents the results of the combined effort of the NRC and the industry to produce improved Standard Technical Specifications (STS), Revision 1 for General Electric BWR/4 Plants. The changes reflected in Revision 1 resulted from the experience gained from license amendment applications to convert to these improved STS or to adopt partial improvements to existing technical specifications. This NUREG is the result of extensive public technical meetings and discussions between the Nuclear Regulatory Commission (NRC) staff and various nuclear power plant licensees, Nuclear Steam Supply System (NSSS) Owners Groups, NSSS vendors, and the Nuclear Energy Institute (NEI). The improved STS were developed based on the criteria in the Final Commission Policy Statement on Technical Specifications Improvements for Nuclear Power Reactors, dated July 22, 1993. The improved STS will be used as the basis for individual nuclear power plant licensees to develop improved plant-specific technical specifications. This report contains three volumes. Volume 1 contains the specifications for all chapters and sections of the improved STS. Volume 2 contains he Bases for Chapters 2.0 and 3.0, and Sections 3.1-3.3 of the improved STS. This document, Volume 3, contains the Bases for Sections 3.4-3.10 of the improved STS

  18. Standard technical specifications: Babcock and Wilcox plants. Volume 3, Revision 1: Bases (Sections 3.4--3.9)

    International Nuclear Information System (INIS)

    1995-04-01

    This report documents the results of the combined effort of the NRC and the industry to produce improved Standard Technical Specifications (STS), Revision 1 for Babcock and Wilcox Plants. The changes reflected in Revision 1 resulted from the experience gained from license amendment applications to convert to these improved STS or to adopt partial improvements to existing technical specifications. This NUREG is the result of extensive public technical meetings and discussions between the Nuclear Regulatory Commission (NRC) staff and various nuclear power plant licensees, Nuclear Steam Supply System (NSSS) Owners Groups, NSSS vendors, and the Nuclear Energy Institute (NEI). The improved STS were developed based on the criteria in the Final Commission Policy Statement on Technical Specifications Improvements for Nuclear Power Reactors, dated July 22, 1993. The improved STS will be used as the basis for individual nuclear power plant licensees to develop improved plant-specific technical specifications. This report contains three volumes. Volume 1 contains the Specifications for all chapters and sections of the improved STS. Volume 2 contains the Bases for Chapters 2.0 and 3.0, and Sections 3.1--3.3 of the improved STS. Volume 3 contains the Bases for Sections 3.4--3.9 of the improved STS

  19. Technical issues to improve diuresis renography

    International Nuclear Information System (INIS)

    Ponnappan, Asha; Mathur, M.; Kumar, S.

    2011-01-01

    Radionuclide renal scintigraphy is a safe and valuable method provides important functional data to assist in the diagnosis and management of patients with a variety of known or suspected diseases involving the kidney, ureters and bladder. The objective of this article is optimal technique for renography which can improve image quality, which in turn improves diagnostic efficacy

  20. Performance improvement plan in customer technical services

    International Nuclear Information System (INIS)

    Lachambre, L.

    1995-01-01

    This presentation centred around the philosophy, goals, and initiatives associated with Gaz Metropolitain's performance improvement plan. Various aspects of the plan including customer surveys, new customer service policies, the creation of small working units, the decentralization of the Montreal service department, and customer-harmonized shift schedules were explored. Implementation of new service plans and contracts, the formation of improvement groups related to human resources, human resource and productivity management, leadership training, and the use of performance indicators were also explained

  1. METHOD IMPROVEMENT FOR DETERMINING THE TECHNICAL LEVEL OF CIVIL AIRCRAFT

    Directory of Open Access Journals (Sweden)

    2016-01-01

    Full Text Available Aircraft are high-tech engineering products which are characterized by a wide range of properties including the two most important groups that respectively characterize the efficiency and technical level.Improving the aircraft efficiency is an essential factor for air transport development, but the efficiency can not be fully describe the technical system, especially in forecasting and new technology requirements development. Aircraft de- signer must evaluate the prospects of a technical solution, but it’s not always possible to calculate the efficiency accuratelyat the design stage. The operator should be able to choose the most technically-advanced aircraft available in the market inorder not to let it grow obsolete quickly. This determines the need for non-economic evaluation of technical systems that can be done by assessment of their technical level.The technical level is a general index that includes a set of technical perfection indicators. Technical perfection is reflected in terms of material and energy intensity, in terms of ergonomics, safety, etc. and is achieved as a result of origi- nal design solutions, the use of new high-strength low-density materials, the introduction of advanced technological pro-cesses, calculation methods, verification, testing, etc.There is a tight connection between the product properties and its weight, because weight is the material reflection of these properties. Therefore, improvement of the product properties usually leads to an intense increase of its weight. To deal with this phenomenon is only possible with widely using scientific and technical progress results. In accordance with this, the technical perfection can be interpreted as a major component of quality that is created without the weight increase. This approach requires investment in research and testing new technical solutions.The method was developed to determine the technical level of civil long-haul aircraft which has been modified to

  2. Computer Support of Semantic Text Analysis of a Technical Specification on Designing Software

    OpenAIRE

    Zaboleeva-Zotova, Alla; Orlova, Yulia

    2009-01-01

    The given work is devoted to development of the computer-aided system of semantic text analysis of a technical specification. The purpose of this work is to increase efficiency of software engineering based on automation of semantic text analysis of a technical specification. In work it is offered and investigated a technique of the text analysis of a technical specification is submitted, the expanded fuzzy attribute grammar of a technical specification, intended for formaliza...

  3. Rigorous Specification and Low-Latency Implementation of Technical Market Indicators

    OpenAIRE

    Bakanov, Konstantin; Spence, Ivor; Vandierendonck, Hans; Gillan, Charles J

    2014-01-01

    Technical market indicators are tools used by technical an- alysts to understand trends in trading markets. Technical (market) indicators are often calculated in real-time, as trading progresses. This paper presents a mathematically- founded framework for calculating technical indicators. Our framework consists of a domain specific language for the un- ambiguous specification of technical indicators, and a run- time system based on Click, for computing the indicators. We argue that our soluti...

  4. Evaluation of River Bend Station Unit 1 Technical Specifications

    International Nuclear Information System (INIS)

    Baxter, D.E.; Bruske, S.J.

    1985-08-01

    This document was prepared for the Nuclear Regulatory Commission (NRC) to assist them in determining whether the River Bend Station Unit 1 Technical Specifications (T/S), which govern plant systems configurations and operations, are in conformance with the requirements of the Final Safety Analysis Report (FSAR) as amended, and the requirements of the Safety Evaluation Report (SER) as supplemented. A comparative audit of the FSAR as amended, and the SER as supplemented was performed with the River Bend T/S. Several discrepancies were identified and subsequently resolved through discussions with the cognizant NRC reviewer, NRC staff reviewers and/or utility representatives. The River Bend Station Unit 1 T/S, to the extent reviewed, are in conformance with the FSAR and SER

  5. Evaluation of Perry Nuclear Power Plant Unit 1 technical specifications

    International Nuclear Information System (INIS)

    Baxter, D.E.; Bruske, S.J.

    1985-11-01

    This document was prepared for the Nuclear Regulatory Commission (NRC) to assist them in determining whether the Perry Nuclear Power Plant Unit 1 Technical Specifications (T/S), which govern plant systems configurations and operations, are in conformance with the requirements of the Final Safety Analysis Report (FSAR) as amended, and the requirements of the Safety Evaluation Report (SER) as supplemented. A comparative audit of the FSAR as amended, and the SER as supplemented was performed with the Perry T/S. Several discrepancies were identified and subsequently resolved through telephone conversations with the staff reviewer and the utility representative. Pending completion of the resolutions noted in Parts 3 and 4 of this report, the Perry Nuclear Power Plant Unit 1 T/S, to the extent reviewed, are in conformance with the FSAR and SER

  6. Technical report for effective estimation and improvement of quality system

    International Nuclear Information System (INIS)

    Kim, Kwan Hyun

    2000-06-01

    This technical report provides the methods on how to improve the Quality System, in R and D part. This report applies on the quality assurance(QA) programmes of the design, fabrication in nuclear projects. The organization having overall responsibility for the nuclear power item design, preservation, fabrication shall be described in this report in each stage of improvement of QA systems

  7. Optimization Strategy of the APR+ BOP Technical Specifications

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Yoon Sang; Lee, Jae Gon; Han, Sung Heum [KHNP CRI, Daejeon (Korea, Republic of)

    2016-10-15

    The BOP is one of the key factors for successful project implementation of NPP. In constructing the APR1400 NPP, the BOP procurement has been one of the biggest concerns. Due to the design changes and increased capacity of equipment in NPP, lots of BOPs should be ‘first supplied equipment’ [hereinafter, ‘FSE’]. The manufacture-ability, and the performances of FSEs have not been fully proved and tested, manufacturers and suppliers are requested to submit Reports for Equipment Qualification Evaluation in accordance with 10 CFR 50.49, IEEE 323. They need at least 1-2 years’ tests for Environment Qualification (EQ) and Seismic Qualification (SQ). This study is focused how to prepare the BOP purchase specifications in order to control the FSEs, especially in safety class equipment. With the optimization plan for BOP packages of this study, the FSEs’ occurrence can be reasonably controlled as low as possible. For successful NPP project, the concerns in procuring BOPs shall be fully analyzed beforehand. Now Korea is preparing new era of APR+, with closing the time of APR1400. The technical specification of APR+ BOPs can be developed and prepared successfully and very effectively according to this optimization plan. This will be a great contribution not only in constructing APR+ in time, but also in exporting APR+ overseas, all over the world in the future.

  8. Spatial Visualization ability improves with and without studying Technical Drawing.

    Science.gov (United States)

    Contreras, María José; Escrig, Rebeca; Prieto, Gerardo; Elosúa, M Rosa

    2018-03-27

    The results of several studies suggest that spatial ability can be improved through direct training with tasks similar to those integrated in the tests used to measure the ability. However, there is a greater interest in analyzing the effectiveness of indirect training such as games or of learning subjects that involve spatial processes to a certain extent. Thus, the objective of the present study was to analyze whether the indirect training in Technical Drawing improved the Spatial Visualization ability of Architecture students. For this purpose, a group of students enrolled in Fundamentals of Architecture were administered two tests, a Spatial Visualization task and an Abstract Reasoning task, at the beginning and the end of a semester, after having received training through the subjects "Technical Drawing I: Geometry and Perception" and "Projects I." The results of this group were compared with those of a control group of students enrolled in a Mathematics degree, who were also pre-post evaluated but had not received the training in Technical Drawing. The study showed a significant pre-post improvement in both, Visualization and reasoning. However, this improvement occurred in both groups, thereby concluding that this improvement was not due to indirect training. Furthermore, no significant differences were found between men and women in any of the groups or conditions. These results clarify those of an earlier study where improvement in Visualization after training in Technical Drawing was found but did not include a comparison with a control condition. The control condition has proved to be important in order to consider the limitations of the effect of Technical Drawing on said improvement.

  9. Recommendations for the treatment of aging in standard technical specifications

    International Nuclear Information System (INIS)

    Orton, R.D.; Allen, R.P.

    1995-09-01

    As part of the US Nuclear Regulatory Commission's Nuclear Plant Aging Research Program, Pacific Northwest Laboratory (PNL) evaluated the standard technical specifications for nuclear power plants to determine whether the current surveillance requirements (SRs) were effective in detecting age-related degradation. Nuclear Plant Aging Research findings for selected systems and components were reviewed to identify the stressors and operative aging mechanisms and to evaluate the methods available to detect, differentiate, and trend the resulting aging degradation. Current surveillance and testing requirements for these systems and components were reviewed for their effectiveness in detecting degraded conditions and for potential contributions to premature degradation. When the current surveillance and testing requirements appeared ineffective in detecting aging degradation or potentially could contribute to premature degradation, a possible deficiency in the SRs was identified that could result in undetected degradation. Based on this evaluation, PNL developed recommendations for inspection, surveillance, trending, and condition monitoring methods to be incorporated in the SRs to better detect age- related degradation of these selected systems and components

  10. Improvement of the Teaching of Vocational Technical Education ...

    African Journals Online (AJOL)

    Administrator

    The purpose of this paper is to discuss how scientific supervision can be used to improve the teaching of vocational-. Technical Education. The early concept of scientific supervision has been replaced with a technology of instruction which involves the creation of curriculum materials in line with instructional technologists' ...

  11. Improvement of the Teaching of Vocational Technical Education ...

    African Journals Online (AJOL)

    The purpose of this paper is to discuss how scientific supervision can be used to improve the teaching of vocational- Technical Education. The early concept of scientific supervision has been replaced with a technology of instruction which involves the creation of curriculum materials in line with instructional technologists' ...

  12. TECHNICAL AND ORGANIZATIONAL IMPROVEMENTS OF PACKAGING PRODUCTION PROCESS

    Directory of Open Access Journals (Sweden)

    Anna Rudawska

    2016-06-01

    Full Text Available Due to customer driven economies, today’s world markets are characterized by high fluctuations in market demand and the frequent arrival of new technologies and new products. To stay competitive in such markets manufacturing companies require continuous improvements both in technical and organizational areas of their activity. The paper presents results of the diagnosis provided in the manufacturing area of the company producing cardboard packages and recommendations to make the production process more efficient. Especially, among the proposed technical and organizational recommendations the most important ones are: automation of certain elements of the production process and changes in production plant layout.

  13. Technical solutions to improve performance of the recycled cement concrete aggregates for durable road pavements

    OpenAIRE

    MUSCALU, Marius; RADU, Andrei; LUNGU, Irina; TARANU, Nicolae; BUDESCU, Mihai; CAZACLIU, Bogdan

    2013-01-01

    This paper presents the results of the research analyses and laboratory studies, aiming to develop design guidelines and suitable technologies for the construction of durable and environmental friendly rigid pavements by using recycled cement concrete, resulted from various demolition works. Various recycling principles and technologies, specific laboratory methods of improved technical solutions to enhance wear coefficients, density homogeneity, mixture contamination and water absorption ...

  14. TECHNICAL BASIS FOR VENTILATION REQUIREMENTS IN TANK FARMS OPERATING SPECIFICATIONS DOCUMENTS

    Energy Technology Data Exchange (ETDEWEB)

    BERGLIN, E J

    2003-06-23

    This report provides the technical basis for high efficiency particulate air filter (HEPA) for Hanford tank farm ventilation systems (sometimes known as heating, ventilation and air conditioning [HVAC]) to support limits defined in Process Engineering Operating Specification Documents (OSDs). This technical basis included a review of older technical basis and provides clarifications, as necessary, to technical basis limit revisions or justification. This document provides an updated technical basis for tank farm ventilation systems related to Operation Specification Documents (OSDs) for double-shell tanks (DSTs), single-shell tanks (SSTs), double-contained receiver tanks (DCRTs), catch tanks, and various other miscellaneous facilities.

  15. The key to technical translation, v.1 concept specification

    CERN Document Server

    Hann, Michael

    1992-01-01

    This handbook for German/English/German technical translators at all levels from student to professional covers the root terminologies of the spectrum of scientific and engineering fields. The work is designed to give technical translators direct insight into the main error sources occurring in their profession, especially those resulting from a poor understanding of the subject matter and the usage of particular terms to designate different concepts in different branches of technology. The style is easy to read and suitable for nonnative English speakers and translators with no engineering ex

  16. Handbook of methods for risk-based analysis of technical specifications

    International Nuclear Information System (INIS)

    Samanta, P.K.; Kim, I.S.; Mankamo, T.; Vesely, W.E.

    1996-01-01

    Technical Specifications (TS) requirements for nuclear power plants define the Limiting Conditions for Operations (LCOs) and Surveillance Requirements (SRs) to assure safety during operation. In general, these requirements are based on deterministic analyses and engineering judgments. Improvements in these requirements are facilitated by the availability of plant-specific Probabilistic Risk Assessments (PRAs). The US Nuclear Regulatory Commission (USNRC) Office of Research sponsored research to develop systematic, risk-based methods to improve various aspects of TS requirements. A handbook of methods summarizing such risk-based approaches has been completed in 1994. It is expected that this handbook will provide valuable input to NRC's present work in developing guidance for using PRA in risk-informed regulation. The handbook addresses reliability and risk-based methods for evaluating allowed outage times (AOTs), action statements requiring shutdown where shutdown risk may be substantial, surveillance test intervals (STIs), managing plant configurations, and scheduling maintenance

  17. Implementation of quality improvement techniques for management and technical processes in the ACRV project

    Science.gov (United States)

    Raiman, Laura B.

    1992-01-01

    Total Quality Management (TQM) is a cooperative form of doing business that relies on the talents of everyone in an organization to continually improve quality and productivity, using teams and an assortment of statistical and measurement tools. The objective of the activities described in this paper was to implement effective improvement tools and techniques in order to build work processes which support good management and technical decisions and actions which are crucial to the success of the ACRV project. The objectives were met by applications in both the technical and management areas. The management applications involved initiating focused continuous improvement projects with widespread team membership. The technical applications involved applying proven statistical tools and techniques to the technical issues associated with the ACRV Project. Specific activities related to the objective included working with a support contractor team to improve support processes, examining processes involved in international activities, a series of tutorials presented to the New Initiatives Office and support contractors, a briefing to NIO managers, and work with the NIO Q+ Team. On the technical side, work included analyzing data from the large-scale W.A.T.E.R. test, landing mode trade analyses, and targeting probability calculations. The results of these efforts will help to develop a disciplined, ongoing process for producing fundamental decisions and actions that shape and guide the ACRV organization .

  18. Implementation of quality improvement techniques for management and technical processes in the ACRV project

    Science.gov (United States)

    Raiman, Laura B.

    1992-12-01

    Total Quality Management (TQM) is a cooperative form of doing business that relies on the talents of everyone in an organization to continually improve quality and productivity, using teams and an assortment of statistical and measurement tools. The objective of the activities described in this paper was to implement effective improvement tools and techniques in order to build work processes which support good management and technical decisions and actions which are crucial to the success of the ACRV project. The objectives were met by applications in both the technical and management areas. The management applications involved initiating focused continuous improvement projects with widespread team membership. The technical applications involved applying proven statistical tools and techniques to the technical issues associated with the ACRV Project. Specific activities related to the objective included working with a support contractor team to improve support processes, examining processes involved in international activities, a series of tutorials presented to the New Initiatives Office and support contractors, a briefing to NIO managers, and work with the NIO Q+ Team. On the technical side, work included analyzing data from the large-scale W.A.T.E.R. test, landing mode trade analyses, and targeting probability calculations. The results of these efforts will help to develop a disciplined, ongoing process for producing fundamental decisions and actions that shape and guide the ACRV organization .

  19. 10 CFR 50.36a - Technical specifications on effluents from nuclear power reactors.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Technical specifications on effluents from nuclear power...; Ineligibility of Certain Applicants § 50.36a Technical specifications on effluents from nuclear power reactors..., including expected occurrences, as low as is reasonably achievable, each licensee of a nuclear power reactor...

  20. Comparison of methods applicable to evaluation of nuclear power plant technical specifications

    International Nuclear Information System (INIS)

    Cho, N.Z.; Bozoki, G.E.; Youngblood, R.W.

    1986-01-01

    This study compares three probabilistic methods based on the static fault tree analysis, time-dependent unavailability analysis, and Markov analysis, which can be used to evaluate technical specifications in nuclear power plants. They are tested on a sample problem which was devised to closely represent the important and essential characteristics that should be addressed in determination and evaluation of the technical specifications

  1. Analysis of Technical Specifications of the Egyptian and French Electronic Storybooks (e-Storybook)

    Science.gov (United States)

    Atta, Mohammed Mahmoud; Abd El Wahab, Shaimaa Mahmoud

    2015-01-01

    This research aims at analysing technical specifications in a sample of Egyptian and French electronic storybooks (e-storybooks), to identify similarities and differences in technical specifications of children's e-storybooks and create a verified analysis list to be used for evaluation of e-storybooks. For this purpose, 32 e-storybooks in CD…

  2. 77 FR 45282 - NRC Position on the Relationship Between General Design Criteria and Technical Specification...

    Science.gov (United States)

    2012-07-31

    ... Position on the Relationship Between General Design Criteria and Technical Specification Operability AGENCY... relationship between the general design criteria (GDC) for nuclear power plants and technical specification... Communications Branch, Division of Policy and Rulemaking, Office Nuclear Reactor Regulation, Mail Stop: OWFN-12-D...

  3. 76 FR 189 - Notice of Availability of the Models for Plant-Specific Adoption of Technical Specifications Task...

    Science.gov (United States)

    2011-01-03

    ... [pressurized water reactor] Operability Requirements and Actions for RCS [reactor coolant system] Leakage...) and non- concurrence, are available electronically under ADAMS Accession Numbers ML101340278 and... FURTHER INFORMATION CONTACT: Mr. Matthew Hamm, Reactor Systems Engineer, Technical Specifications Branch...

  4. Technical specifications on the welding in fuel reprocessing plants

    Energy Technology Data Exchange (ETDEWEB)

    Karino, Motonobu; Uryu, Mitsuru; Matsui, N.; Nakazawa, Fumio; Imanishi, Makoto; Koizumi; Kazuhiko; Sugawara, Junichi; Tanaka, Hideo

    1999-04-01

    The past specifications SGN of the welding in JNC was reexamined for the reprocessing plants in order to further promote the quality control. The specification first concerns the quality of raw materials, items of the quality tests, material management, and qualification standards of the welders. It extends over details of the welding techniques, welding design, welding testings, inspection and the judgment standards. (H. Baba)

  5. Dowel Bar Retrofit Mix Design and Specification : Technical Report

    Science.gov (United States)

    2012-01-01

    Current INDOT specifications for repair materials to be used in dowel bar retrofit (DBR) applications (Sections 507.08 and 901.07 of INDOTs Book of Specifications) are based, in large part, on the requirements of ASTM C 928 and the manufacturer-pr...

  6. Study of the technical specifications for the diesels generator of Juragua NPP

    International Nuclear Information System (INIS)

    Vilaragut Llanes, J.J.

    1996-01-01

    The Technical Specifications of a nuclear power plant specify the limits for plant operation from the safety point of view. These operational safety rules were originally defined on the basis of deterministic analysis and engineering judgement. The Probabilistic safety Assessment, constitutes a tool to analyze of the risk effect in the Technical Specifications Rules, and makes possible a relative comparison of the rules from the risk point of view. This paper studies the technical specifications for the diesels generators of Juragua Nuclear Power Plant and for that was used the probabilistic methodology . It is presented the evaluation of the some parameters as surveillance testing, test interval, repairs time, diesel degradation and AOT

  7. UXO Engineering Design. Technical Specification and ConceptualDesign

    Energy Technology Data Exchange (ETDEWEB)

    Beche, J-F.; Doolittle, L.; Greer, J.; Lafever, R.; Radding, Z.; Ratti, A.; Yaver, H.; Zimmermann, S.

    2005-04-23

    The design and fabrication of the UXO detector has numerous challenges and is an important component to the success of this study. This section describes the overall engineering approach, as well as some of the technical details that brought us to the present design. In general, an array of sensor coils is measuring the signal generated by the UXO object in response to a stimulation provided by the driver coil. The information related to the location, shape and properties of the object is derived from the analysis of the measured data. Each sensor coil is instrumented with a waveform digitizer operating at a nominal digitization rate of 100 kSamples per second. The sensor coils record both the large transient pulse of the driver coil and the UXO object response pulse. The latter is smaller in amplitude and must be extracted from the large transient signal. The resolution required is 16 bits over a dynamic range of at least 140 dB. The useful signal bandwidth of the application extends from DC to 40 kHz. The low distortion of each component is crucial in order to maintain an excellent linearity over the full dynamic range and to minimize the calibration procedure. The electronics must be made as compact as possible so that the response of its metallic parts has a minimum signature response. Also because of a field system portability requirement, the power consumption of the instrument must be kept as low as possible. The theory and results of numerical and experimental studies that led to the proof-of-principle multitransmitter-multireceiver Active ElectroMagnetic (AEM) system, that can not only accurately detect but also characterize and discriminate UXO targets, are summarized in LBNL report-53962: ''Detection and Classification of Buried Metallic Objects, UX-1225''.

  8. Understanding the technical content of requirements in specification document

    DEFF Research Database (Denmark)

    Sudin, Mohd Nizam Bin; Ahmed-Kristensen, Saeema

    2011-01-01

    in practice, 97 statements from 2 specification documents were analyzed in detail and the results are reported in this paper. These statements were analyzed quantitatively and qualitatively based on a pre-defined coding scheme. The results of the study show that the majority of requirements were related...

  9. Diabetic foot workshop: Improving technical and educational skills for nurses.

    Science.gov (United States)

    Aalaa, Maryam; Sanjari, Mahnaz; Shahbazi, Samimeh; Shayeganmehr, Zahra; Abooeirad, Maryam; Amini, Mohammad Reza; Adibi, Hossien; Mehrdad, Neda

    2017-01-01

    Diabetes mellitus as one of the most common metabolic disorders has some complications, one of the main ones is diabetic foot (DF). Appropriate care and education prevents 85% of diabetic foot amputations. An ideal management to prevent and treat diabetic foot necessitates a close collaboration between the health team members and the diabetic patient. Therefore, improving nurses' knowledge about DF care and advancement in the quality of care provided by the nurses could significantly improve diabetic foot prevention and management. Therefore, the aim of DF workshop was to improve technical and educational skills of the nurses to prevent and manage diabetic foot. Considering the vital role of the nurses in providing DF care, EMRI decided to conduct Diabetic foot workshop for them. The following five steps were designed for the 14 coordinating sessions in the workshop: Goals definition, deciding about attendees, location selection, creating agenda, and developing a follow-up plan. "Diabetic Foot Workshop for Nurses" provides appropriate training to DF nurses at the national level; and combining theory and practice in this workshop not only increases nurses' knowledge, but also improves their skills in the field of the diabetic foot. Providing education and care to patients by DF nurse specialists instead of general nurses could be an important output of this workshop, which may lead to DF prevention and amputation decrease in the long term.

  10. Technical specification for transferring tank construction data to the Oak Ridge Environmental Information System (OREIS)

    International Nuclear Information System (INIS)

    1996-06-01

    The primary goal of this technical specification is to meet the consolidated environmental data requirements defined by the Federal Facility Agreement (FFA) and the Tennessee Oversight Agreement as they pertain to tank construction data maintained in Oak Ridge, Tennessee, by the US Department of Energy's Maintenance and Operations contractor Lockheed Martin Energy Systems, Inc., and prime contractors to the Department of Energy. This technical specification describes the organizational responsibilities for loading tank construction data into OREIS, describes the logical and physical data transfer files, addresses business rules and submission rules, addresses configuration control of this technical specification, and addresses required changes to the current OREIS data base structure based on site requirements. This technical specification addresses the tank construction data maintained by the Y-12, K-25, and ORNL sites that will be sent to OREIS. The initial submission of data will include only inactive Environmental Restoration tanks as specified by the FFA

  11. Technical specification for a 25 MV tandem electrostatic accelerator

    International Nuclear Information System (INIS)

    Jones, C.M.; Biggerstaff, J.A.; Blair, J.K.; Ball, J.B.; Larson, J.D.; Martin, J.A.; McConnell, J.W.; Milner, W.T.; Murray, J.A.; Ziegler, N.F.

    1975-08-01

    Specifications are given for an accelerator system to consist of a 25 MV tandem electrostatic accelerator and specified ancillary equipment, including an injector, a beam transport system, a vacuum system, a control system, and a system for storage of the insulating gas and transport of the gas to and from the accelerator. The insulating gas shall be SF 6 . The tandem electrostatic accelerator shall be vertical in orientation and of folded construction, and shall be installed in a new structure adjacent to the Oak Ridge Isochronous Cyclotron. (auth)

  12. Handbook of methods for risk-based analysis of Technical Specification requirements

    International Nuclear Information System (INIS)

    Samanta, P.K.; Vesely, W.E.

    1993-01-01

    Technical Specifications (TS) requirements for nuclear power plants define the Limiting Conditions for Operation (LCOs) and Surveillance Requirements (SRs) to assure safety during operation. In general, these requirements were based on deterministic analysis and engineering judgments. Experiences with plant operation indicate that some elements of the requirements are unnecessarily restrictive, while others may not be conducive to safety. Improvements in these requirements are facilitated by the availability of plant specific Probabilistic Safety Assessments (PSAs). The use of risk and reliability-based methods to improve TS requirements has gained wide interest because these methods can: quantitatively evaluate the risk impact and justify changes based on objective risk arguments. Provide a defensible basis for these requirements for regulatory applications. The United States Nuclear Regulatory Commission (USNRC) Office of Research is sponsoring research to develop systematic risk-based methods to improve various aspects of TS requirements. The handbook of methods, which is being prepared, summarizes such risk-based methods. The scope of the handbook includes reliability and risk-based methods for evaluating allowed outage times (AOTs), action statements requiring shutdown where shutdown risk may be substantial, surveillance test intervals (STIs), defenses against common-cause failures, managing plant configurations, and scheduling maintenances. For each topic, the handbook summarizes methods of analysis and data needs, outlines the insights to be gained, lists additional references, and presents examples of evaluations

  13. Handbook of methods for risk-based analysis of technical specification requirements

    International Nuclear Information System (INIS)

    Samanta, P.K.; Vesely, W.E.

    1994-01-01

    Technical Specifications (TS) requirements for nuclear power plants define the Limiting Conditions for Operation (LCOs) and Surveillance Requirements (SRs) to assure safety during operation. In general, these requirements were based on deterministic analysis and engineering judgments. Experiences with plant operation indicate that some elements of the requirements are unnecessarily restrictive, while others may not be conducive to safety. Improvements in these requirements are facilitated by the availability of plant specific Probabilistic Safety Assessments (PSAs). The use of risk and reliability-based methods to improve TS requirements has gained wide interest because these methods can: Quantitatively evaluate the risk and justify changes based on objective risk arguments; Provide a defensible basis for these requirements for regulatory applications. The US NRC Office of Research is sponsoring research to develop systematic risk-based methods to improve various aspects of TS requirements. The handbook of methods, which is being prepared, summarizes such risk-based methods. The scope of the handbook includes reliability and risk-based methods for evaluating allowed outage times (AOTs), action statements requiring shutdown where shutdown risk may be substantial, surveillance test intervals (STIs), defenses against common-cause failures, managing plant configurations, and scheduling maintenances. For each topic, the handbook summarizes methods of analysis and data needs, outlines the insights to be gained, lists additional references, and presents examples of evaluations

  14. Yakima Habitat Improvement Project Master Plan, Technical Report 2003.

    Energy Technology Data Exchange (ETDEWEB)

    Golder Associates, Inc.

    2003-04-22

    result of the planning effort leading to this Master Plan, a Technical Working Group (TWG) was established that represents most, if not all, fish and wildlife agencies/interests in the subbasin. This TWG met regularly throughout the planning process to provide input and review and was instrumental in the development of this plan. Preparation of this plan included the development of a quantitative prioritization process to rank 40,000 parcels within the Urban Growth Area based on the value of fish and wildlife habitat each parcel provided. Biological and physical criteria were developed and applied to all parcels through a GIS-based prioritization model. In the second-phase of the prioritization process, the TWG provided local expert knowledge and review of the properties. In selecting the most critical areas within the Urban Growth Area for protection, this project assessed the value of fish and wildlife habitat on the Yakima River. Well-developed habitat acquisition efforts (e.g., Yakima River Basin Water Enhancement Project by the Bureau of Reclamation and Yakama Nation acquisition projects) are already underway on the Yakima River mainstem. These efforts, however, face several limitations in protection of floodplain function that could be addressed through the support of the Yakima Habitat Improvement Project. This Master Plan integrates tributary habitat acquisition efforts with those ongoing on the Yakima River to best benefit fish and wildlife in the Urban Growth Area. The parcel ranking process identified 25 properties with the highest fish and wildlife value for habitat acquisition in the Yakima Urban Area. These parcels contain important fish and wildlife corridors on Ahtanum and Wide Hollow Creeks and the Naches River. The fifteen highest-ranking parcels of the 25 parcels identified were considered very high priority for protection of fish and wildlife habitat. These 15 parcels were subsequently grouped into four priority acquisition areas. This Master Plan

  15. Rotary ATPases: models, machine elements and technical specifications.

    Science.gov (United States)

    Stewart, Alastair G; Sobti, Meghna; Harvey, Richard P; Stock, Daniela

    2013-01-01

    Rotary ATPases are molecular rotary motors involved in biological energy conversion. They either synthesize or hydrolyze the universal biological energy carrier adenosine triphosphate. Recent work has elucidated the general architecture and subunit compositions of all three sub-types of rotary ATPases. Composite models of the intact F-, V- and A-type ATPases have been constructed by fitting high-resolution X-ray structures of individual subunits or sub-complexes into low-resolution electron densities of the intact enzymes derived from electron cryo-microscopy. Electron cryo-tomography has provided new insights into the supra-molecular arrangement of eukaryotic ATP synthases within mitochondria and mass-spectrometry has started to identify specifically bound lipids presumed to be essential for function. Taken together these molecular snapshots show that nano-scale rotary engines have much in common with basic design principles of man made machines from the function of individual "machine elements" to the requirement of the right "fuel" and "oil" for different types of motors.

  16. The impact of technical specification surveillance requirements and allowable outage times on plant availability

    International Nuclear Information System (INIS)

    Webster, S.A.; Finnicum, D.J.

    1985-01-01

    Surveillances required to be conducted by a plant's Technical Specifications have resulted in plant shutdowns and lost availability. This paper looks at shutdowns which have occurred due to required surveillance testing and insufficient repair time allowed by Technical Specifications. A loss of plant availability of almost 3% per plant year was found for U.S. pressurized water reactors during the five year period, 1979 to 1984. This figure excludes major problems which required plant shutdown whether or not mandated by the Technical Specifications. In addition to their affect on availability, such shutdowns can add to the challenges to plant safety systems and can affect plant aging by increasing the thermal cycles on plant components

  17. Evaluation of the Technical Adequacy of Three Methods for Identifying Specific Learning Disabilities Based on Cognitive Discrepancies.

    Science.gov (United States)

    Stuebing, Karla K; Fletcher, Jack M; Branum-Martin, Lee; Francis, David J

    2012-01-01

    This study used simulation techniques to evaluate the technical adequacy of three methods for the identification of specific learning disabilities via patterns of strengths and weaknesses in cognitive processing. Latent and observed data were generated and the decision-making process of each method was applied to assess concordance in classification for specific learning disabilities between latent and observed levels. The results showed that all three methods had excellent specificity and negative predictive values, but low to moderate sensitivity and very low positive predictive values. Only a very small percentage of the population (1%-2%) met criteria for specific learning disabilities. In addition to substantial psychometric issues underlying these methods, general application did not improve the efficiency of the decision model, may not be cost effective because of low base rates, and may result in many children receiving instruction that is not optimally matched to their specific needs.

  18. 78 FR 33863 - Relationship Between General Design Criteria and Technical Specification Operability

    Science.gov (United States)

    2013-06-05

    ... No: 2013-13352] NUCLEAR REGULATORY COMMISSION [NRC-2012-0179] Relationship Between General Design... Issue Summary (RIS) 2013-05, ``NRC Position on the Relationship Between General Design Criteria and Technical Specification Operability.'' This RIS clarifies the NRC staff's position on the relationship...

  19. Technical specifications: Seabrook Station, Unit 1 (Docket No. 50-443)

    International Nuclear Information System (INIS)

    1990-03-01

    The Seabrook Station, Unit 1 Technical Specifications were prepared by the US Nuclear Regulatory Commission to set forth the limits, operating conditions, and other requirements applicable to a nuclear reactor facility as set forth in Section 50.36 of 10 CFR Part 50 for the protection of the health and safety of the public

  20. 78 FR 12063 - Meeting for Software Developers on the Technical Specifications for Common Formats for Patient...

    Science.gov (United States)

    2013-02-21

    ... disability is needed, please contact the Food and Drug Administration (FDA) Office of Equal Employment... Medicare & Medicaid Services, Food and Drug Administration, Health Resources and Services Administration... patient safety event data. The technical specifications consist of the following: [cir] Data dictionary...

  1. 77 FR 9252 - Meeting for Software Developers on the Technical Specifications for Common Formats for Patient...

    Science.gov (United States)

    2012-02-16

    ... other reasonable accommodation for a disability is needed, please contact the Food and Drug...)--the Centers for Disease Control and Prevention, Centers for Medicare & Medicaid Services, Food and... technical specifications consist of the following: Data dictionary--defines data elements and their...

  2. Improved Controls for Fusion RF Systems. Final technical report

    International Nuclear Information System (INIS)

    Casey, Jeffrey A.

    2011-01-01

    We have addressed the specific requirements for the integrated systems controlling an array of klystrons used for Lower Hybrid Current Drive (LHCD). The immediate goal for our design was to modernize the transmitter protection system (TPS) for LHCD on the Alcator C-Mod tokamak at the MIT Plasma Science and Fusion Center (MIT-PSFC). Working with the Alcator C-Mod team, we have upgraded the design of these controls to retrofit for improvements in performance and safety, as well as to facilitate the upcoming expansion from 12 to 16 klystrons. The longer range goals to generalize the designs in such a way that they will be of benefit to other programs within the international fusion effort was met by designing a system which was flexible enough to address all the MIT system requirements, and modular enough to adapt to a large variety of other requirements with minimal reconfiguration

  3. Final priority; technical assistance to improve state data capacity--National Technical Assistance Center to improve state capacity to accurately collect and report IDEA data. Final priority.

    Science.gov (United States)

    2013-05-20

    The Assistant Secretary for Special Education and Rehabilitative Services announces a priority under the Technical Assistance to Improve State Data Capacity program. The Assistant Secretary may use this priority for competitions in fiscal year (FY) 2013 and later years. We take this action to focus attention on an identified national need to provide technical assistance (TA) to States to improve their capacity to meet the data collection and reporting requirements of the Individuals with Disabilities Education Act (IDEA). We intend this priority to establish a TA center to improve State capacity to accurately collect and report IDEA data (Data Center).

  4. Technical specification action requirements for AFW system failures: Method development and application to four PWR plants

    International Nuclear Information System (INIS)

    Mankamo, T.; Kim, I.S.; Yang, Ji Wu; Samanta, P.K.

    1996-01-01

    Failures in the auxiliary feedwater (AFW) system of pressurized water reactors (PWRs) are considered to involve substantial risk whether a decision is made to either continue power operation while repair is being done, or to shut down the plant to undertake repairs. Technical specification action requirements usually require immediate plant shutdown in the case of multiple failures in the system (in some cases, immediate repair of one train is required when all AFW trains fail). This paper presents a probabilistic risk assessment-based method to quantitatively evaluate and compare both the risks of continued power operation and of shutting the plant down, given known failures in the system. The method is applied to the AFW system for four different PWRs. Results show that the risk of continued power operation and plant shutdown both are substantial, but the latter is larger than the former over the usual repair time. This was proven for four plants with different designs: two operating Westinghouse plants, one operating Asea-Brown Boveri Combustion Engineering Plant, and one of evolutionary design. The method can be used to analyze individual plant design and to improve AFW action requirements using risk-informed evaluations

  5. Handbook of methods for risk-based analyses of technical specifications

    International Nuclear Information System (INIS)

    Samanta, P.K.; Kim, I.S.; Mankamo, T.; Vesely, W.E.

    1994-12-01

    Technical Specifications (TS) requirements for nuclear power plants define the Limiting Conditions for Operation (LCOs) and Surveillance Requirements (SRs) to assure safety during operation. In general, these requirements are based on deterministic analysis and engineering judgments. Experiences with plant operation indicate that some elements of the requirements are unnecessarily restrictive, while a few may not be conducive to safety. The US Nuclear Regulatory Commission (USNRC) Office of Research has sponsored research to develop systematic risk-based methods to improve various aspects of TS requirements. This handbook summarizes these risk-based methods. The scope of the handbook includes reliability and risk-based methods for evaluating allowed outage times (AOTs), scheduled or preventive maintenance, action statements requiring shutdown where shutdown risk may be substantial, surveillance test intervals (STIs), and management of plant configurations resulting from outages of systems, or components. For each topic, the handbook summarizes analytic methods with data needs, outlines the insights to be gained, lists additional references, and gives examples of evaluations

  6. Technical support for the Ukrainian State Committee for Nuclear Radiation Safety on specific waste issues

    International Nuclear Information System (INIS)

    Little, C.A.

    1995-01-01

    The government of Ukraine, a now-independent former member of the Soviet Union, has asked the United States to assist its State Committee for Nuclear and Radiation Safety (SCNRS) in improving its regulatory control in technical fields for which it has responsibility. The US Nuclear Regulatory Commission (NRC) is providing this assistance in several areas, including management of radioactive waste and spent fuel. Radioactive wastes resulting from nuclear power plant operation, maintenance, and decommissioning must be stored and ultimately disposed of appropriately. In addition, radioactive residue from radioisotopes used in various industrial and medical applications must be managed. The objective of this program is to provide the Ukrainian SCNRS with the information it needs to establish regulatory control over uranium mining and milling activities in the Zheltye Vody (Yellow Waters) area and radioactive waste disposal in the Pripyat (Chernobyl) area among others. The author of this report, head of the Environmental Technology Section, Health Sciences Research Division of Oak Ridge National Laboratory, accompanied NRC staff to Ukraine to meet with SCNRS staff and visit sites in question. The report highlights problems at the sites visited and recommends license conditions that SCNRS can require to enhance safety of handling mining and milling wastes. The author's responsibility was specifically for the visit to Zheltye Vody and the mining and milling waste sites associated with that facility. An itinerary for the Zheltye Vody portion of the trip is included as Appendix A

  7. 77 FR 58421 - Model Safety Evaluation for Plant-Specific Adoption of Technical Specifications Task Force...

    Science.gov (United States)

    2012-09-20

    ... Item Improvement Process AGENCY: Nuclear Regulatory Commission. ACTION: Notice of availability. SUMMARY... Agencywide Documents Access and Management System (ADAMS): You may access publicly available documents online... currently require operating the ventilation system for at least 10 continuous hours with the heaters...

  8. 78 FR 22554 - Document to Support Submission of an Electronic Common Technical Document-Specifications for File...

    Science.gov (United States)

    2013-04-16

    ... Types Using Electronic Common Technical Document Specifications; Availability AGENCY: Food and Drug... the electronic Common Technical Document (eCTD) specifications: ``Specifications for File Format Types... acceptance of advertising and promotional labeling in the eCTD format, it has become necessary to expand the...

  9. Waste management issues and their potential impact on technical specifications of CANDU fuel materials

    International Nuclear Information System (INIS)

    Tait, J.C.; Johnson, L.H.

    1997-01-01

    The technical specifications for the composition of nuclear fuels and materials used in Canada's CANDU reactors have been developed by AECL and materials manufacturers, taking into account considerations specific to their manufacture and the effect of minor impurities on fuel behaviour in reactor. Nitrogen and chlorine are examples of UO 2 impurities, however, where there is no technical specification limit. These impurities are present in the source materials or introduced in the fabrication process and are neutron activated to 14 C and 36 C1, which after 129 I , are the two most significant contributors to dose in safety assessments for the disposal of used fuel. For certain impurities, environmental factors, particularly the safety of the disposal of used fuels, should be taken into consideration when deriving 'allowable' impurity limits for nuclear fuel materials. (author)

  10. Use of PSA Level 2 analysis for improving containment performance. Report of a technical committee meeting

    International Nuclear Information System (INIS)

    1998-03-01

    In order to discuss and exchange experience on different aspects of methods associated with Level 2 PSA and its applications for improving containment performance, the IAEA held a Technical Committee meeting in Vienna in December 1996. The meeting, which was attended by 26 participants from 20 Member States, provided a broad forum for discussion. The meeting addressed the issues related to the actual performance of Level 2 PSA studies as well as the insights gained from applications to improve containment performance. Particular attention was given to studies and applications for WWER type reactors, for which Level 2 work is still in its early stages, and for channel type reactors where modelling of accident progression is complex and significantly different from vessel type light water reactors. This TECDOC contains the papers presented at the meeting and the results of extensive discussions which were held in specific working groups

  11. Recent improvements in the NASA technical report server

    Science.gov (United States)

    Maa, Ming-Hokng; Nelson, Michael L.

    1995-01-01

    The NASA Technical Report Server (NTRS), a World Wide Web (WWW) report distribution service, has been modified to allow parallel database queries, significantly decreasing user access time by an average factor of 2.3, access from clients behind firewalls and/or proxies which truncate excessively long Uniform Resource Locators (URL's), access to non-Wide Area Information Server (WAIS) databases, and compatibility with the Z39-50.3 protocol.

  12. Simulating extracorporeal membrane oxygenation emergencies to improve human performance. Part II: assessment of technical and behavioral skills.

    Science.gov (United States)

    Anderson, JoDee M; Murphy, Allison A; Boyle, Kristine B; Yaeger, Kim A; Halamek, Louis P

    2006-01-01

    Healthcare professionals are expected to make rapid, correct decisions in critical situations despite what may be a lack of real practical experience in a particular crisis situation. Successful resolution of a medical crisis depends upon demonstration not only of appropriate technical skills but also of key behavioral skills (eg, leadership, communication, and teamwork). We have developed a hands-on, high fidelity, simulation-based training program (ECMO Sim) to provide healthcare professionals with the opportunity to learn and practice the technical and behavioral skills necessary to manage ECMO emergencies. Nine ECMO nurse specialists participated in two sequential randomly assigned simulated ECMO emergencies. The simulated emergencies were captured on videotape and reviewed with the subjects during facilitated debriefings that occurred immediately following each scenario. All videotapes were scored for key technical and behavioral skills by reviewers blinded to the sequence of the scenarios. The ratings of the subjects' technical and behavioral skills in each scenario were compared. Subjects performed key technical skills correctly more often in the second simulated ECMO emergency. In addition, their response times for three out of five specific technical tasks improved from the first to the second simulated emergency by an average of 27 seconds. Subjects' behavioral skills were rated more highly by masked reviewers in the second simulated ECMO emergency. The improvement in comprehensive behavioral scores from the first to the second scenario reached statistical significance in eight of nine subjects. After exposure to high-fidelity simulated ECMO emergencies, subjects demonstrated significant improvements in their technical and behavioral skills. ECMO Sim creates a learning environment that readily supports the acquisition of the technical and behavioral skills that are important in solving clinically significant, potentially life-threatening problems that can

  13. The use of a checklist improves anaesthesiologists' technical and non-technical performance for simulated malignant hyperthermia management.

    Science.gov (United States)

    Hardy, Jean-Baptiste; Gouin, Antoine; Damm, Cédric; Compère, Vincent; Veber, Benoît; Dureuil, Bertrand

    2018-02-01

    Anaesthesiologists may occasionally manage life-threatening operating room (OR) emergencies. Managing OR emergencies implies real-time analysis of often complicated situations, prompt medical knowledge retrieval, coordinated teamwork and effective decision making in stressful settings. Checklists are recommended to improve performance and reduce the risk of medical errors. This study aimed to assess the usefulness of the French Society of Anaesthesia and Intensive Care's (SFAR) "Malignant Hyperthermia" (MH) checklist on a simulated episode of MH crisis and management thereof by registered anesthesiologists. Twenty-four anaesthesiologists were allocated to 2 groups (checklist and control). Their technical performance in adherence with the SFAR guidelines was assessed by a 30-point score and their non-technical performance was assessed by the Anaesthetists' Non-Technical Skills (ANTS) score. Every task completion was assessed independently. Data are shown as median (first-third quartiles). Anaesthesiologists in the checklist group had higher technical performance scores (24/30 (21.5-25) vs 18/30 (15.5-19.5), P=0.002) and ANTS scores (56.5/60 (47.5-58) vs 48.5/60 (41-50.5), P=0.024). They administered the complete initial dose of dantrolene (2mg/kg) more quickly (15.7 minutes [13.9-18.3] vs 22.4 minutes [18.6-25]) than the control group (P=0.017). However, anaesthesiologists deemed the usability of the checklist to be perfectible. Registered anaesthesiologists' use of the MH checklist during a simulation session widely improved their adherence to guidelines and non-technical skills. This study strongly suggests the benefit of checklist tools for emergency management. Notwithstanding, better awareness and training for anaesthesiologists could further improve the use of this tool. Copyright © 2017 Société française d'anesthésie et de réanimation (Sfar). Published by Elsevier Masson SAS. All rights reserved.

  14. Technical specifications for the successful fabrication of laminated seismic isolation bearings

    International Nuclear Information System (INIS)

    Kulak, R.F.

    1992-01-01

    High damping laminated elastomeric bearings are becoming one of the preferred devices for isolating large buildings and structures. IN the United States, the current reference design for the Advanced Liquid Metal Reactor uses laminated bearings for seismic isolation. These bearing are constructed from alternating layers of rubber and steel plates. They are typically designed for shear strains between 50 to 100 percent and expected to sustain two to three times these levels for beyond design basis loading considerations. The technical specifications used to procure these bearings are an important factor in assuring that the bearings that are installed under nuclear structures meet the performance requirements of the design. The key aspects of the current version of the Technical Specifications are discussed in this paper

  15. Technical specifications for the successful fabrication of laminated seismic isolation bearings

    International Nuclear Information System (INIS)

    Kulak, R.F.

    1992-01-01

    High damping steel-laminated elastomeric seismic isolation bearings are becoming a preferred device for isolating large buildings and structures. In the United States, the current reference design for the Advanced Liquid Metal Reactor uses laminated bearings for seismic isolation. These bearings are constructed from alternating layers of rubber and steel plates. They are typically designed for shear strains between 50 to 100 percent and expected to sustain two to three times these levels for beyond design basis loading considerations. The technical specifications used to procure these bearings are an important factor in assuring that the bearings meet the performance requirements of the design. The key aspects of the current version of the Technical Specifications are discussed in this paper. (author)

  16. Technical specifications for the successful fabrication of laminated seismic isolation bearings

    Energy Technology Data Exchange (ETDEWEB)

    Kulak, R.F.

    1992-05-01

    High damping laminated elastomeric bearings are becoming one of the preferred devices for isolating large buildings and structures. IN the United States, the current reference design for the Advanced Liquid Metal Reactor uses laminated bearings for seismic isolation. These bearing are constructed from alternating layers of rubber and steel plates. They are typically designed for shear strains between 50 to 100 percent and expected to sustain two to three times these levels for beyond design basis loading considerations. The technical specifications used to procure these bearings are an important factor in assuring that the bearings that are installed under nuclear structures meet the performance requirements of the design. The key aspects of the current version of the Technical Specifications are discussed in this paper.

  17. Technical specifications for the successful fabrication of laminated seismic isolation bearings

    Energy Technology Data Exchange (ETDEWEB)

    Kulak, R.F.

    1992-01-01

    High damping laminated elastomeric bearings are becoming one of the preferred devices for isolating large buildings and structures. IN the United States, the current reference design for the Advanced Liquid Metal Reactor uses laminated bearings for seismic isolation. These bearing are constructed from alternating layers of rubber and steel plates. They are typically designed for shear strains between 50 to 100 percent and expected to sustain two to three times these levels for beyond design basis loading considerations. The technical specifications used to procure these bearings are an important factor in assuring that the bearings that are installed under nuclear structures meet the performance requirements of the design. The key aspects of the current version of the Technical Specifications are discussed in this paper.

  18. Improving Service Quality in Technical Education: Use of Interpretive Structural Modeling

    Science.gov (United States)

    Debnath, Roma Mitra; Shankar, Ravi

    2012-01-01

    Purpose: The purpose of this paper is to identify the relevant enablers and barriers related to technical education. It seeks to critically analyze the relationship amongst them so that policy makers can focus on relevant parameters to improve the service quality of technical education. Design/methodology/approach: The present study employs the…

  19. Small-sided game training improves aerobic capacity and technical skills in basketball players.

    Science.gov (United States)

    Delextrat, A; Martinez, A

    2014-05-01

    The aim of this study was to compare the effects of 2 training interventions based on small-sided games (SGG) and high-intensity interval training (HIT) on physical and technical performance of male junior basketball players. A secondary objective was to investigate if these effects were similar in starting and bench players. 18 players participated in a pre-testing session, 6-weeks intervention period and a post-testing session. Pre- and post-sessions involved assessments of aerobic fitness, repeated sprint ability (RSA), defensive and offensive agility, upper and lower body power, shooting and passing skills. Mixed-design analysis of variance (ANOVA) with Bonferroni corrected pairwise comparisons examined the effects of time and type of intervention on physical and technical performances. The main results showed that both interventions resulted in similar improvements in aerobic capacity (+3.4% vs. +4.1%), with greater improvements in bench players compared to starting players (+7.1% vs. +1.1%, Pbasketball players during the season. However, when RSA is targeted, more specific training seems necessary. © Georg Thieme Verlag KG Stuttgart · New York.

  20. Development of Integral Effect Test Facility P and ID and Technical Specification for SMART Fluid System

    International Nuclear Information System (INIS)

    Lee, Sang Il; Jung, Y. H.; Yang, H. J.; Song, S. Y.; Han, O. J.; Lee, B. J.; Kim, Y. A.; Lim, J. H.; Park, K. W.; Kim, N. G.

    2010-01-01

    SMART integral test loop is the thermal hydraulic test facility with a high pressure and temperature for simulating the major systems of the prototype reactor, SMART-330. The objective of this project is to conduct the basic design for constructing SMART ITL. The major results of this project include a series of design documents, technical specifications and P and ID. The results can be used as the fundamental materials for making the detailed design which is essential for manufacturing and installing SMART ITL

  1. Critical evaluation of the nonradiological environmental technical specifications. Program description, summary, and recommendations. Vol. 1

    International Nuclear Information System (INIS)

    Adams, S.M.; Cunningham, P.A.; Gray, D.D.; Kumar, K.D.; Witten, A.J.

    1976-01-01

    A comprehensive study of the data collected as part of the environmental Technical Specifications program for eight nuclear power plants was conducted for the Office of Nuclear Regulatory Research of the U.S. Nuclear Regulatory commission. This report includes a summary of the screening phase in which the adequacy of the hydrothermal and ecological monitoring data for each plant were evaluated, and the summary and recommendations resulting from a detailed examination of the three nuclear power plants selected in the initial screening

  2. THERMAL COMPOSITE COATINGS IMPROVING QUALITY OF TECHNICAL MEANS OF TRANSPORT

    Directory of Open Access Journals (Sweden)

    Andrzej POSMYK

    2015-06-01

    Full Text Available The paper presents the thermal properties of composite insulating material designed for producing of technical means of transport. This material can be coated on most of engineering materials. The matrix of this material is an acrylic resin ant non porous ceramic microspheres made of alumina are the reinforcing phase. Thanks to that into the spheres almost vacuum (0,13 Pa dominants and a big amount of spheres pro thickness unit is it possible to achieve low thermal conductivity. Usage of these coatings for producing of cooling cabins on vehicles let us to reduce of fuel for maintain of given temperature. Usage of these coatings in planes flying on high altitudes (temperature up to -60 allows to reduce of fuel consumption for heating. It has an important influence on transport quality and quality costs.

  3. Nuclear power operating experience and technical improvement in Japan

    International Nuclear Information System (INIS)

    Toyota, M.

    1983-01-01

    LWR technology in Japan, originally introduced from the United States of America, is now almost entirely supplied domestically. During the initial stage of plant operation, electric power companies experienced various troubles such as intergranular stress corrosion cracking (IGSCC) in the piping in BWRs and steam generator (S/G) tube leaks in PWRs, which once reduced the capacity factor to about 40%. As a result of efforts to investigate the causes of the troubles and to establish countermeasures, which were applied to the plants in operation and under construction for improvement, as well as to shorten the period of regular inspection and to extend the operation cycle, the capacity factor has been improved to 60% since 1980. In 1975 an LWR improvement and standardization programme was launched to aim at improvement of reliability and availability factor and reduction of occupational radiation exposure with the development of domestic technology based on construction and operating experience. The First Phase Programme, which ran from 1975 to 1977, established countermeasures to preclude these troubles and improved workability by enlargement of the containment vessel. The Second Phase Programme followed and ran until 1981. The major steps taken during this period include the adoption of new IGSCC-resistant material and improved core design for BWRs and the improvement of fuels and S/Gs for PWRs. With these improvements, the capacity factor is now expected to reach a 75% level and occupational radiation exposure should be reduced by 50%. A Third Phase Programme will centre on the test and development programme for advanced BWRs and PWRs now under way to further improve the availability factor and reliability while also minimizing radiation exposure. (author)

  4. Differential and Integral Calculus in careers of technical sciences. Specificities of their teaching

    Directory of Open Access Journals (Sweden)

    Iván Javier Villamar-Alvarado

    2017-12-01

    Full Text Available The Differential and Integral Calculus has great relevance for the professionals of the technical sciences since it provides them with a solid theoretical-conceptual body to process information, to use models that simulate real processes, to solve technical problems, to work in multidisciplinary projects and to communicate with precision. In spite of this relevance, there are numerous international dissatisfactions related to their learning by training engineers. The objective was to unveil the specificities of the teaching-learning process of this discipline that favor a successful appropriation of its content by the future engineers. The result was to unveil the didactic need to resolve the dialectical contradiction that manifests itself between the systematization of the engineering functionality of the aforementioned content and its contextualized interdisciplinary generalization. As a consequence, the need arises to create new didactic proposals that overcome this contradiction, as a way to perfect the teaching-learning process of this discipline in the engineering careers.

  5. Procurement in the Imaging Department: The Need for Understanding Technical Specifications

    International Nuclear Information System (INIS)

    Bwonya, N.S.M.

    2015-01-01

    Procurement is the function responsible for the acquisition of goods, works or services in an Organization. The Governments has three main ways of purchasing: Cash Imprest, Invitation of Quotation and Open National Tender. A Tenderer is a domestic, foreign, legal or natural person offering to supply goods, services or perform work assignments. Procurement involves needs identified by users, the procurement will seek approval from the AIE holder after which Preparation of specifications, Identifification of supplier (source) for delivering of the item to be stored after proper marking and verification. Specifications or Specs is a term mainly used in the acquisition of many items and in a Radiology department these include equipment, supplies and contrast media. A specification is a technical standard, tailored to perform certain functions and It is a set of requirements satisfied by a material, design, product or service. A technical evaluation team sets specifications and ideally will comprise of the following; a Radiologist, Senior Radiographer; an Engineer, Supplies professional and a Senior person (Nurse) whose department will need Radiological Services

  6. A MODEL FOR INTEGRATED SOFTWARE TO IMPROVE COMMUNICATION POLICY IN DENTAL TECHNICAL LABS

    Directory of Open Access Journals (Sweden)

    Minko M. Milev

    2017-06-01

    Full Text Available Introduction: Integrated marketing communications (IMC are all kinds of communications between organisations and customers, partners, other organisations and society. Aim: To develop and present an integrated software model, which can improve the effectiveness of communications in dental technical services. Material and Methods: The model of integrated software is based on recommendations of a total of 700 respondents (students of dental technology, dental physicians, dental technicians and patients of dental technical laboratories in Northeastern Bulgaria. Results and Discussion: We present the benefits of future integrated software to improve the communication policy in the dental technical laboratory that meets the needs of fast cooperation and well-built communicative network between dental physicians, dental technicians, patients and students. Conclusion: The use of integrated communications could be a powerful unified approach to improving the communication policy between all players at the market of dental technical services.

  7. Coaching Non-technical Skills Improves Surgical Residents' Performance in a Simulated Operating Room.

    Science.gov (United States)

    Yule, Steven; Parker, Sarah Henrickson; Wilkinson, Jill; McKinley, Aileen; MacDonald, Jamie; Neill, Adrian; McAdam, Tim

    2015-01-01

    To investigate the effect of coaching on non-technical skills and performance during laparoscopic cholecystectomy in a simulated operating room (OR). Non-technical skills (situation awareness, decision making, teamwork, and leadership) underpin technical ability and are critical to the success of operations and the safety of patients in the OR. The rate of developing assessment tools in this area has outpaced development of workable interventions to improve non-technical skills in surgical training and beyond. A randomized trial was conducted with senior surgical residents (n = 16). Participants were randomized to receive either non-technical skills coaching (intervention) or to self-reflect (control) after each of 5 simulated operations. Coaching was based on the Non-Technical Skills For Surgeons (NOTSS) behavior observation system. Surgeon-coaches trained in this method coached participants in the intervention group for 10 minutes after each simulation. Primary outcome measure was non-technical skills, assessed from video by a surgeon using the NOTSS system. Secondary outcomes were time to call for help during bleeding, operative time, and path length of laparoscopic instruments. Non-technical skills improved in the intervention group from scenario 1 to scenario 5 compared with those in the control group (p = 0.04). The intervention group was faster to call for help when faced with unstoppable bleeding in the final scenario (no. 5; p = 0.03). Coaching improved residents' non-technical skills in the simulated OR compared with those in the control group. Important next steps are to implement non-technical skills coaching in the real OR and assess effect on clinically important process measures and patient outcomes. Copyright © 2015 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

  8. Does teaching non-technical skills to medical students improve those skills and simulated patient outcome?

    Science.gov (United States)

    Herbstreit, Frank; Kehren, Clemens; Chittamadathil, Jilson; Wolfertz, Sandra; Dirkmann, Daniel; Kluge, Annette; Peters, Jürgen

    2017-01-01

    Objectives The purpose of this study is to evaluate the effects of a tailor-made, non-technical skills seminar on medical student’s behaviour, attitudes, and performance during simulated patient treatment. Methods Seventy-seven students were randomized to either a non-technical skills seminar (NTS group, n=43) or a medical seminar (control group, n=34). The human patient simulation was used as an evaluation tool. Before the seminars, all students performed the same simulated emergency scenario to provide baseline measurements. After the seminars, all students were exposed to a second scenario, and behavioural markers for evaluating their non-technical skills were rated. Furthermore, teamwork-relevant attitudes were measured before and after the scenarios, and perceived stress was measured following each simulation. All simulations were also evaluated for various medical endpoints. Results Non-technical skills concerning situation awareness (pteamwork (pattitude ‘handling errors’ improved significantly in the NTS group (p<.05, r=0.34). Perceived stress decreased from simulation I to II in both groups. Medical endpoints and patients´ outcome did not differ significantly between the groups in simulation II. Conclusions This study highlights the effectiveness of a single brief seminar on non-technical skills to improve student’s non-technical skills. In a next step, to improve student’s handling of emergencies and patient outcomes, non-technical skills seminars should be accompanied by exercises and more broadly embedded in the medical school curriculum. PMID:28355594

  9. Technical specification: Mixed-oxide pellets for the light-water reactor irradiation demonstration test

    International Nuclear Information System (INIS)

    Cowell, B.S.

    1997-06-01

    This technical specification is a Level 2 Document as defined in the Fissile Materials Disposition Program Light-Water Reactor Mixed-oxide Fuel Irradiation Test Project Plan. It is patterned after the pellet specification that was prepared by Atomic Energy of Canada, Limited, for use by Los Alamos National Laboratory in fabrication of the test fuel for the Parallex Project, adjusted as necessary to reflect the differences between the Canadian uranium-deuterium reactor and light-water reactor fuels. This specification and the associated engineering drawing are to be utilized only for preparation of test fuel as outlined in the accompanying Request for Quotation and for additional testing as directed by Oak Ridge National Laboratory or the Department of Energy

  10. Impact of shutdown risk on risk-based assessment of technical specifications

    International Nuclear Information System (INIS)

    Deriot, S.

    1992-10-01

    This paper describes the current work performed by the Research and Development Division of EDF concerning risk-based assessment of Operating Technical Specifications (OTS). The current risk-based assessment of OTS at EDF is presented. Then, the level 1 Probabilistic Safety Assessment of unit 3 of the Paluel nuclear power station (called PSA 1300) is described. It is fully computerized and takes into account the risk in shutdown states. A case study is presented. It shows that the fact of considering shutdown risk suggests that the current OTS should be modified

  11. Efficiency improvements in pipeline transportation systems. Technical report, Task 3

    Energy Technology Data Exchange (ETDEWEB)

    Banks, W. F.; Horton, J. H.

    1977-01-01

    This report identifies those potential energy-conservative pipeline innovations that are most energy- and cost-effective, and formulates recommendations for the R, D, and D programs needed to exploit those opportunities. From a candidate field of over twenty classes of efficiency improvements, eight systems are recommended for pursuit. Most of these possess two highly important attributes: large potential energy savings and broad applicability outside the pipeline industry. The R, D, and D program for each improvement and the recommended immediate next step are described. The eight programs recommended for pursuit are: gas-fired combined-cycle compressor station; internally cooled internal combustion engine; methanol-coal slurry pipeline; methanol-coal slurry-fired and coal-fired engines; indirect-fired coal-burning combined-cycle pump station; fuel-cycle pump station; internal coatings in pipelines; and drag-reducing additives in liquid pipelines.

  12. Technical improvements in 19th century Belgian window glass production

    Science.gov (United States)

    Lauriks, Leen; Collette, Quentin; Wouters, Ine; Belis, Jan

    Glass was used since the Roman age in the building envelope, but it became widely applied together with iron since the 19th century. Belgium was a major producer of window glass during the nineteenth century and the majority of the produced window glass was exported all over the world. Investigating the literature on the development of 19th century Belgian window glass production is therefore internationally relevant. In the 17th century, wood was replaced as a fuel by coal. In the 19th century, the regenerative tank furnace applied gas as a fuel in a continuous glass production process. The advantages were a clean production, a more constant and higher temperature in the furnace and a fuel saving. The French chemist Nicolas Leblanc (1787-1793) and later the Belgian chemist Ernest Solvay (1863) invented processes to produce alkali out of common salt. The artificial soda ash improved the quality and aesthetics of the glass plates. During the 19th century, the glass production was industrialized, influencing the operation of furnaces, the improvement of raw materials as well as the applied energy sources. Although the production process was industrialized, glassblowing was still the work of an individual. By improving his work tools, he was able to create larger glass plates. The developments in the annealing process followed this evolution. The industry had to wait until the invention of the drawn glass in the beginning of the 20th century to fully industrialise the window glass manufacture process.

  13. Safety protection and technical improvement of 60Co irradiation facilities

    International Nuclear Information System (INIS)

    Zhou Yongxing; Liang Cannan

    1993-01-01

    To ensure personal safety, some improvements has been made in the design of 60 Co irradiation compartment. The shielding door was interlocked while the 60 Co source to be lifted to the irradiation position or lowered to the shielded position. A universal change-over switch was used to cut the power supply when the source moved beyond the limits. Both γ-ray alarm and a closed-TV system were adopted. The electromagnetic attraction method was employed to shift the 60 Co source from the Pb container to the source pipe

  14. INVESTIGATION OF MICROPROCESSOR CURRENT PROTECTION LINES WITH IMPROVED INDICES OF TECHNICAL PERFECTION

    Directory of Open Access Journals (Sweden)

    E. V. Buloichyk

    2014-01-01

    Full Text Available Technical perfection improvement of microprocessor current protection of distribution networks lines is provided by introduction of asymmetrical fault mode determination and fault location functions in the algorithm of its functioning. As a result of computing experiment the basic indices of the technical perfection of current protection have been obtained in the paper. The paper proves high efficiency of the proposed methods that ensure selective and proper operation in the different modes of the controlled line.

  15. The superomedial thigh flap in scrotal reconstruction: Technical steps to improve cosmetic results

    Directory of Open Access Journals (Sweden)

    Ayat Allah Oufkir

    2013-01-01

    Full Text Available The superomedial thigh flap is a reliable and easy method for scrotal reconstruction described in 1980 and infrequently reported in the literature since its description. We used it for four patients presenting scrotal defects after Fournier′s gangrene with some technical modifications to improve the esthetic results and to facilitate the closure of the donor area. We describe the technical steps and the results.

  16. Technical Specification action statements requiring shutdown. A risk perspective with application to the RHR/SSW systems of a BWR

    Energy Technology Data Exchange (ETDEWEB)

    Mankamo, T. [Avaplan Oy, Espoo (Finland); Kim, I.S.; Samanta, P.K. [Brookhaven National Lab., Upton, NY (United States)

    1993-11-01

    When safety systems fail during power operation, the limiting conditions for operation (LCOs) and associated action statements of technical specifications typically require that the plant be shut down within the limits of allowed outage time (AOT). However, when a system needed to remove decay heat, such as the residual heat removal (RHR) system, is inoperable or degraded, shutting down the plant may not necessarily be preferable, from a risk perspective, to continuing power operation over a usual repair time, giving priority to the repairs. The risk impact of the basic operational alternatives, i.e., continued operation or shutdown, was evaluated for failures in the RHR and standby service water (SSW) systems of a boiling-water reactor (BWR) nuclear power plant. A complete or partial failure of the SSW system fails or degrades not only the RHR system but other front-line safety systems supported by the SSW system. This report presents the methodology to evaluate the risk impact of LCOs and associated AOT; the results of risk evaluation from its application to the RHR and SSW systems of a BWR; the findings from the risk-sensitivity analyses to identify alternative operational policies; and the major insights and recommendations to improve the technical specifications action statements.

  17. Experiences with applications of PSA results for optimization/revision of technical specifications for operation of nuclear power plants

    International Nuclear Information System (INIS)

    Vijaya, A.K.; Guptan, Rajee; Mohan, Nalini; Ghadge, S.G.; Bajaj, S.S.

    2006-01-01

    Over the past few years, NPCIL has performed comprehensive Level-1 Probabilistic Safety Assessment (PSA) for a 220 MWe Pressurised Heavy Water Reactor (PHWR) at Kakrapar Atomic Power Station (KAPS) and for the first 540 MWe PHWR at Tarapur Atomic Power Project (TAPP- 3 and 4). The major objective of these PSAs was to present an integrated picture of the safety of the plant to identify and understand key plant vulnerabilities. As a result of the availability of these PSAs, there is a desire to use them to operate the plants in the most efficient manner practicable. In recent years, the operation of Indian Nuclear Power Plants has been characterized by improved availability/capacity factors and reduced forced outages. Frequency of planned outages is also being reduced. In order to achieve this, the PSAs are now being used as an engineering tool for optimization of Technical Specifications with regard to Allowed Outage Time (AOT) and Surveillance Test Intervals (STIs). USNRC Regulatory Guides have published Probabilistic Safety Criteria (PSC) which can be used as guidelines for optimization of technical specification, taking into consideration Instantaneous (conditional) Risk, Cumulative Risk over the AOT period, and Average Risk over a long period. This paper discusses the approaches followed for such optimization. Case studies are also presented. (author)

  18. External Technical Support for School Improvement: Critical Issues from the Chilean Experience

    Science.gov (United States)

    Osses, Alejandra; Bellei, Cristián; Valenzuela, Juan Pablo

    2015-01-01

    To what extent school improvement processes can be initiated and sustained from the outside has been a relevant question for policy-makers seeking to increase quality in education. Since 2008, the Chilean Government is strongly promoting the use of external technical support (ETS) services to support school improvement processes, as part of the…

  19. 75 FR 27341 - Increasing Market and Planning Efficiency Through Improved Software; Notice of Technical...

    Science.gov (United States)

    2010-05-14

    ... resources and demand resources (DR, DG, and storage) in planning software. Additional issues to be discussed... Market and Planning Efficiency Through Improved Software; Notice of Technical Conference To Discuss Increasing Market and Planning Efficiency Through Improved Software May 7, 2010. Take notice that Commission...

  20. A Lunar Broad Band Seismometer on SELENE-2 / LUNETTE missions: Focus on VBB technical improvements

    Science.gov (United States)

    Nebut, T.; Gagnepain-Beyneix, J.; Lognonne, P.; Kobayashi, N.; Giardini, D.; Christensen, U. R.; de Raucourt, S.; Bierwirth, M.; Mimoun, D.; Zweifel, P.; Tillier, S.; Robert, O.; Escande, N.; Gabsi, T.; Lecomte, B.; Pot, O.; Mance, D.; Roll, R.; Shiraishi, H.; Garcia, R. F.; Yamada, R.; Mocquet, A.; Banerdt, B.; Tanaka, S.

    2010-12-01

    The Moon will be explored during the next decade by a series of missions, especially from Japan, China, India and USA. We present here the status of the development of space qualified Very Broad Band seismometer in Europe. This instrument, completed by Japanese Short Period Seismometers, is called Lunar Broad Band Seismometer (LBBS). It is considered for the Japanese project SELENE-2 and US project LUNETTE. The main scientific goals are to determine the internal structure of the whole Moon and more specifically the composition and size of the lunar core. The LBBS instrument is the result of an international consortium: A 3 axis short period (SP) seismometer (ISAS/JAXA) A 3 axis very broad band (VBB) seismometer (IPGP) A deployment system (DPL) (MPS) A data acquisition system (SEIS-AC) (ETHZ) Both SP and VBB development rely on technical heritage of cancelled space missions (LUNAR-A for the SP, Netlander & Humboldt/ExoMars for the VBB). This technical development lead VBB to reach a Technical Readiness Level (TRL) above 5 (ESA ExoMars PDR), and we aim at TRL 6 within the next few months. The adaptation of the VBB from Mars to Moon conditions and environment is challenging. The resolution has to be improved by a factor of ten and should be inferior to 2.10-11m/s^2/sqrt(Hz) @ 0.1 Hz while the Instrument are supporting very large temperature variations (several 10s of degrees) compared to those of typical VBB seismometers. Using Netlander & ExoMars heritage, It appeared that a trade-off between resolution and VBB thermal sensibility was possible. A passive thermal compensation device was designed and tested at IPGP reducing VBB thermal sensitivity by a factor of 12, and we aim at a factor of 20. It will be possible to improve the resolution consequently if thermal sensitivity is reduced. For Moon missions VBB developments, efforts have been made both on mechanical design and Displacement Capacitive Sensor (DCS). The mechanical part of VBB is an inverted pendulum; the

  1. Technical specifications manual for the MARK-1 pulsed ionizing radiation detection system

    International Nuclear Information System (INIS)

    Lawrence, R.S.; Harker, Y.D.; Jones, J.L.; Hoggan, J.M.

    1993-03-01

    The MARK-1 detection system was developed by the Idaho National Engineering Laboratory for the US Department of Energy Office of Arms Control and Nonproliferation. The completely portable system was designed for the detection and analysis of intense photon emissions from pulsed ionizing radiation sources. This manual presents the technical design specifications for the MARK-1 detection system and was written primarily to assist the support or service technician in the service, calibration, and repair of the system. The manual presents the general detection system theory, the MARK-1 component design specifications, the acquisition and control software, the data processing sequence, and the system calibration procedure. A second manual entitled: Volume 2: Operations Manual for the MARK-1 Pulsed Ionizing Radiation Detection System (USDOE Report WINCO-1108, September 1992) provides a general operational description of the MARK-1 detection system. The Operations Manual was written primarily to assist the field operator in system operations and analysis of the data

  2. Manual of engineering drawing technical product specification and documentation to British and international standards

    CERN Document Server

    Simmons, Colin H; Simmons, Colin

    2012-01-01

    Manual of Engineering Drawing is a comprehensive guide for experts and novices for producing engineering drawings and annotated 3D models that meet the recent BSI and ISO standards of technical product documentation and specifications. This fourth edition of the text has been updated in line with recent standard revisions and amendments. The book has been prepared for international use, and includes a comprehensive discussion of the fundamental differences between the ISO and ASME standards, as well as recent updates regarding legal components, such as copyright, patents, and other legal considerations. The text is applicable to CAD and manual drawing, and it covers the recent developments in 3D annotation and surface texture specifications. Its scope also covers the concepts of pictorial and orthographic projections, geometrical, dimensional and surface tolerancing, and the principle of duality. The text also presents numerous examples of hydraulic and electrical diagrams, applications, bearings, adhesives, ...

  3. Technical specifications manual for the MARK-1 pulsed ionizing radiation detection system. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence, R.S.; Harker, Y.D.; Jones, J.L.; Hoggan, J.M.

    1993-03-01

    The MARK-1 detection system was developed by the Idaho National Engineering Laboratory for the US Department of Energy Office of Arms Control and Nonproliferation. The completely portable system was designed for the detection and analysis of intense photon emissions from pulsed ionizing radiation sources. This manual presents the technical design specifications for the MARK-1 detection system and was written primarily to assist the support or service technician in the service, calibration, and repair of the system. The manual presents the general detection system theory, the MARK-1 component design specifications, the acquisition and control software, the data processing sequence, and the system calibration procedure. A second manual entitled: Volume 2: Operations Manual for the MARK-1 Pulsed Ionizing Radiation Detection System (USDOE Report WINCO-1108, September 1992) provides a general operational description of the MARK-1 detection system. The Operations Manual was written primarily to assist the field operator in system operations and analysis of the data.

  4. Technical specification for the Quality Information Management System (QIMS) Pilot Project

    Energy Technology Data Exchange (ETDEWEB)

    Hall, R.C.; Claussen, L.M.; Thurston, I.

    1992-01-01

    This document contains implementation details for the Quality Information Management System (QIMS) Pilot Project, which has been released for VAX/VMS systems using the INGRES RDBMS. The INGRES Applications-By-Forms (ABF) software development tool was used to define the modules and screens which comprise the QIMS Pilot application. These specifications together with the QIMS information model and corresponding database definition constitute the QIMS technical specification and implementation description presented herein. The QIMS Pilot Project represents a completed software product which has been released for production use. Further extension projects are planned which will release new versions for QIMS. These versions will offer expanded and enhanced functionality to meet further customer requirements not accommodated by the QIMS Pilot Project.

  5. Improvement of specific polymerase chain reaction (PCR) for the ...

    African Journals Online (AJOL)

    Improvement of specific polymerase chain reaction (PCR) for the identification of Mycoplasma capricolum subsp. capripneumoniae. H Ying, Z Nian-zhang, Z Ping, C Yue-feng, G Peng-cheng, Z Jian-jun, L Zhong-xin ...

  6. Interpretation of the results of the technical indicators of agriculture-specific economic”

    OpenAIRE

    Olteanu, Victor

    2014-01-01

    The passage of a technological process is carried out only in circumstances where the process is efficient in economic terms. Assessment of technological processes can be done by means of indicators which can be: economic, technical, economic and technical. Technical-economic indicators used in assessing technological processes are scalars with or without dimensions, which characterizes a substance, a technical device, a system, or a technological process both technically and economically.

  7. Case study on the use of PSA methods: Assessment of technical specifications for the reactor protection system instrumentation

    International Nuclear Information System (INIS)

    1992-10-01

    This case study presents a methodology for the probabilistic evaluation of alternative plant technical specifications regarding system surveillance frequencies and out-of-service times. The methodology is applied to the reactor protection systems of a 4 loop BWR-RESAR-3S type nuclear power plant. The effect of the statistical characteristics of the system on the relative comparison of various sets of technical specifications is examined through sensitivity studies and an uncertainty analysis. Refs, figs and tabs

  8. Does teaching non-technical skills to medical students improve those skills and simulated patient outcome?

    Science.gov (United States)

    Hagemann, Vera; Herbstreit, Frank; Kehren, Clemens; Chittamadathil, Jilson; Wolfertz, Sandra; Dirkmann, Daniel; Kluge, Annette; Peters, Jürgen

    2017-03-29

    The purpose of this study is to evaluate the effects of a tailor-made, non-technical skills seminar on medical student's behaviour, attitudes, and performance during simulated patient treatment. Seventy-seven students were randomized to either a non-technical skills seminar (NTS group, n=43) or a medical seminar (control group, n=34). The human patient simulation was used as an evaluation tool. Before the seminars, all students performed the same simulated emergency scenario to provide baseline measurements. After the seminars, all students were exposed to a second scenario, and behavioural markers for evaluating their non-technical skills were rated. Furthermore, teamwork-relevant attitudes were measured before and after the scenarios, and perceived stress was measured following each simulation. All simulations were also evaluated for various medical endpoints. Non-technical skills concerning situation awareness (ptechnical skills to improve student's non-technical skills. In a next step, to improve student's handling of emergencies and patient outcomes, non-technical skills seminars should be accompanied by exercises and more broadly embedded in the medical school curriculum.

  9. Introduction of a fresh cadaver laboratory during the surgery clerkship improves emergency technical skills.

    Science.gov (United States)

    Nematollahi, Saman; Kaplan, Stephen J; Knapp, Christopher M; Ho, Hang; Alvarado, Jared; Viscusi, Rebecca; Adamas-Rappaport, William

    2015-08-01

    Student acquisition of technical skills during the clinical years of medical school has been steadily declining. To address this issue, the authors instituted a fresh cadaver-based Emergency Surgical Skills Laboratory (ESSL). Sixty-three medical students rotating through the third-year surgery clerkship participated in a 2-hour, fresh cadaver-based ESSL conducted during the first 2 days of the clerkship. The authors evaluated students utilizing both surgical skills and written examination before the ESSL and at 4 weeks post ESSL. Students demonstrated a mean improvement of 64% (±11) (P technical skills and clinical knowledge, respectively. When technical skills were compared between cohorts, there were no differences observed in both pre- and post-testing (P = .08). A fresh cadaver laboratory is an effective method to provide proficiency in emergency technical skills not acquired during the clinical years of medical school. Copyright © 2015 Elsevier Inc. All rights reserved.

  10. Technical specifications for the provision of heat and steam sources for INPP and Visaginas. Final report

    International Nuclear Information System (INIS)

    2003-01-01

    In October 1999, the National Energy Strategy was approved by the Lithuanian Parliament. The National Energy Strategy included the decision to close Unit-1 of INPP before 2005. Later is has been decided to close Unit 2 before the end of 2009 as well. The closure and decommissioning will have heavy impact on the heat supply for the city of Visaginas. Unit 1 and Unit 2 of INPP supplies hot water and steam to INPP for process purposes and for space heating of residential and commercial buildings. When Unit 1 is permanently shut down, reliable heat and steam sources independent of the power plants own heat and steam generation facilities are required for safety reasons in the event of shutdown of the remaining unit for maintenance or in an emergency. These steam and heat sources must be operational before single unit operation is envisaged. Provision of a reliable independent heat and steam source is therefore urgent. After both reactors are shut down permanently, a steam source will be needed at the plant for radioactive waste storage and disposal. INPP and DEA has performed a feasibility study for the provision of a reliable heat source for Ignalina Nuclear Power Plant and Visaginas, and the modernisation of Visaginas district heating system. The objective of this project is to prepare technical specifications for the provision of new heat and steam sources for INPP and Visaginas, and for rehabilitation of the heat transmission pipeline between INPP, the back-up boiler station and Visaginas City. The results of the study are presented in detail in the reports and technical specifications: 1. Transient analysis for Visaginas DH system, 2. Non-destructive testing of boiler stations, pump stations and transmission lines, 3. Conceptual design, 4. Technical specifications, Package 1 to 6. The study has suggested: 1. Construction of new steam boiler station, 2. Construction of new heat only boiler station, 3. Renovation of existing back-up heat only boiler station, 4

  11. Risk-based technical specifications: Development and application of an approach to the generation of a plant specific real-time risk model

    International Nuclear Information System (INIS)

    Puglia, B.; Gallagher, D.; Amico, P.; Atefi, B.

    1992-10-01

    This report describes a process developed to convert an existing PRA into a model amenable to real time, risk-based technical specification calculations. In earlier studies (culminating in NUREG/CR-5742), several risk-based approaches to technical specification were evaluated. A real-time approach using a plant specific PRA capable of modeling plant configurations as they change was identified as the most comprehensive approach to control plant risk. A master fault tree logic model representative of-all of the core damage sequences was developed. Portions of the system fault trees were modularized and supercomponents comprised of component failures with similar effects were developed to reduce the size of the model and, quantification times. Modifications to the master fault tree logic were made to properly model the effect of maintenance and recovery actions. Fault trees representing several actuation systems not modeled in detail in the existing PRA were added to the master fault tree logic. This process was applied to the Surry NUREG-1150 Level 1 PRA. The master logic mode was confirmed. The model was then used to evaluate frequency associated with several plant configurations using the IRRAS code. For all cases analyzed computational time was less than three minutes. This document Volume 2, contains appendices A, B, and C. These provide, respectively: Surry Technical Specifications Model Database, Surry Technical Specifications Model, and a list of supercomponents used in the Surry Technical Specifications Model

  12. Technical evaluation report on the proposed design modifications and technical specification changes on grid voltage degradation for the Millstone Nuclear Power Station, Unit 1

    International Nuclear Information System (INIS)

    Selan, J.C.

    1982-01-01

    This report documents the technical evaluation of the proposed design modifications and Technical Specification change for protection of Class 1E equipment from grid voltage degradation for the Millstone Nuclear Power Station, Unit 1. The review criteria are based on several IEEE standards and the Code of Federal Regulations. The evaluation finds that the licensee has not provided sufficient information on the undervoltage protection system to allow a complete evaluation into the adequacy of protecting the Class 1E equipment from sustained voltage degradation

  13. The critical care nurse. Specific expertise to form in the Superior Technical Nursing

    Directory of Open Access Journals (Sweden)

    Víctor Hugo Rodríguez-Medrano

    2016-06-01

    Full Text Available Higher Technical career in Nursing (TSE meets the need of human resources of the health system, making qualified technicians to be part of multidisciplinary teams in the health care network, applying nursing care throughout the life cycle, with orientation to promotion, prevention, recovery and rehabilitation of health. However inconsistencies are evident in the formative praxis that limit demonstrate the knowledge, skills and attitudes for students in providing nursing service and solving various health problems in users with a specialized nature, in line with current social needs humanist. Why this paper aims to draft pedagogical nature reflections that allow understand the formation of the specific competence nursing care critical in the student user. This result of the doctoral research carried out on this subject, with the application of empirical and theoretical methods which set the proposals that contribute to the solution of this problem.

  14. Catalogue of EDF`s technical specifications (HN reference). Centre of standardization; Catalogue des specifications techniques EDF (reference HN). Centre de normalisation

    Energy Technology Data Exchange (ETDEWEB)

    1998-12-31

    This document edited by Electricite de France (EdF), is a catalogue of the French standard documents relative to any type of electrical material and equipment and which contain the technical specifications of these materials and equipments. A brief description of these specifications is given for each type of material or equipment listed. (J.S.)

  15. Facilitating Site Specific and Citizens Advisory Boards: Running Effective Meetings that Involve Complex Technical Issues

    International Nuclear Information System (INIS)

    Freeman, J.

    2009-01-01

    Environmental cleanup issues at federal sites are more often than not on the agendas of meetings of the Site Specific Advisory Boards (SSABs), also called Citizens Advisory Boards (CABs), that exist at most U.S. Department of Energy (DOE) sites with an Environmental Management (EM) mission. In 1994, when Congress established these committees comprised of local citizens, it enabled community stakeholders to become more directly involved in DOE EM cleanup decisions. This involvement is to help the agency make cost-effective and environmentally sound decisions which lead to faster, safer cleanups. Eight local Boards that fall under the Federal Advisory Committee Act-chartered EM SSAB charter are found in Hanford, Washington; Idaho; Northern New Mexico; Nevada; Oak Ridge, Tennessee; Paducah, Kentucky; Portsmouth, Ohio; and at the Savannah River Site in South Carolina. These boards provide advice and recommendations about EM site-specific issues such as cleanup standards (how clean is clean?), environmental restoration, waste management, the stabilization and disposal of non-stockpile nuclear materials, future land use and long-term stewardship, risk assessment and management, and cleanup science and technology activities. These issues are, by their very nature, loaded with complicated technical terms and strategies, scientific data and interpretations, and long histories of studies and reports. The members of SSABs and CABs rotate on and off the Boards according to defined terms of office, thereby routinely opening the Boards' ranks to new members, many of whom are new to the issues. In addition, members of the public who have access to public comment periods at each Board meeting run up against the same daunting menu of obscure acronyms, scientific terms and notations, and an historical trail which is not always evident except to those involved with the issues over many years. How does a facilitator effectively guide such a group of citizens, each of whom arrives to

  16. Improving the U.S. Navy's Execution of Technical Authority through a Common Risk Management and Technical Assessment Process

    National Research Council Canada - National Science Library

    Tomaiko, Thomas A

    2008-01-01

    .... Technical authority targets compliance with technical criteria and standards. This targeting must be done at the earliest stages of program development and addressed during development of the program acquisition strategy...

  17. Domain-Specific Mappings as Conceptual Categorisers for Scientific and Technical Vocabularies

    Directory of Open Access Journals (Sweden)

    Pilar Durán-Escribano

    2017-10-01

    Full Text Available The analysis of metaphorical lexical units in science and technology provides evidence for their existence either as separate cases or as part of a corresponding conceptual metaphor. In conceptual metaphor, metaphorical expressions constitute productive patterns that unveil the mental mappings that support technical and scientific thought, proving to be a powerful device for conceptualization and a prolific driving force for language growth (Lakoff & Johnson, 1980. Although conceptual metaphor cannot account for all types of linguistic metaphor (Evans, 2013, in this paper we have focused on the former because it implies a systematic set of correspondences between different domains of science and technology supporting the role of conceptual metaphor as a powerful theory constitutive element. The study is based on the qualitative analysis of the metaphorical lexical units included in eight widely accepted specific dictionaries, totalling over 790.000 entries. Attention is focused on domain-specific mappings, in which not only the target but also the source domain pertain to scientific fields, and where the corresponding linguistic expressions keep their univocal meaning in each field. Thus, providing examples from two apparently unrelated fields, earth sciences and telecommunications engineering, the role of domain-specific mappings as conceptual categorisers is studied, underlying the different degrees of categorization involved in the building of new theories (Boyd, 1993, in definitions, and in the expression of new concepts.

  18. Critical evaluation of the nonradiological environmental technical specifications. Volume 3. Peach Bottom Atomic Power Station Units 2 and 3

    Energy Technology Data Exchange (ETDEWEB)

    Adams, S.M.; Cunningham, P.A.; Gray, D.D.; Kumar, K.D.; Witten, A.J.

    1976-08-10

    A comprehensive study of the data collected as part of the environmental Technical Specifications program for Units 2 and 3 of the Peach Bottom Nuclear Power Plant was conducted for the Office of Regulatory Research of the U.S. Nuclear Regulatory Commission. The program included an analysis of both the hydrothermal and ecological monitoring data collected from 1967 through 1976. Specific recommendations are made for improving both the present hydrothermal and ecological monitoring programs. Hydrothermal monitoring would be improved by more complete reporting of in-plant operating parameters. In addition, the present boat surveys could be discontinued, and monitoring efforts could be directed toward expanding the present thermograph network. Ecological monitoring programs were judged to be of high quality because standardized collection techniques, consistent reporting formats, and statistical analyses were performed on all of the data and were presented in an annual report. Sampling for all trophic groups was adequate for the purposes of assessing power plant induced perturbations. Considering the extensive period of preoperational data (six years) and operational data (three years) available for analysis, consideration could be given to reducing monitoring effort after data have been collected for a period when both units are operating at full capacity. In this way, an assessment of the potential ecological impact of the Peach Bottom facility can be made under conditions of maximum plant induced perturbations.

  19. Critical evaluation of the nonradiological environmental technical specifications. Volume 3. Peach Bottom Atomic Power Station Units 2 and 3

    International Nuclear Information System (INIS)

    Adams, S.M.; Cunningham, P.A.; Gray, D.D.; Kumar, K.D.; Witten, A.J.

    1976-01-01

    A comprehensive study of the data collected as part of the environmental Technical Specifications program for Units 2 and 3 of the Peach Bottom Nuclear Power Plant was conducted for the Office of Regulatory Research of the U.S. Nuclear Regulatory Commission. The program included an analysis of both the hydrothermal and ecological monitoring data collected from 1967 through 1976. Specific recommendations are made for improving both the present hydrothermal and ecological monitoring programs. Hydrothermal monitoring would be improved by more complete reporting of in-plant operating parameters. In addition, the present boat surveys could be discontinued, and monitoring efforts could be directed toward expanding the present thermograph network. Ecological monitoring programs were judged to be of high quality because standardized collection techniques, consistent reporting formats, and statistical analyses were performed on all of the data and were presented in an annual report. Sampling for all trophic groups was adequate for the purposes of assessing power plant induced perturbations. Considering the extensive period of preoperational data (six years) and operational data (three years) available for analysis, consideration could be given to reducing monitoring effort after data have been collected for a period when both units are operating at full capacity. In this way, an assessment of the potential ecological impact of the Peach Bottom facility can be made under conditions of maximum plant induced perturbations

  20. 77 FR 19280 - Increasing Market and Planning Efficiency Through Improved Software; Notice of Technical...

    Science.gov (United States)

    2012-03-30

    ...; and use of active and dynamic transmission ratings. Significant computational impediments to... manageable set of scenarios or constraints that improve unit-commitment and dispatch while allowing good... technical support for the webcasts and offers the option of listening to the conferences via phone-bridge...

  1. Improved patient specific seizure detection during pre-surgical evaluation.

    LENUS (Irish Health Repository)

    Chua, Eric C-P

    2011-04-01

    There is considerable interest in improved off-line automated seizure detection methods that will decrease the workload of EEG monitoring units. Subject-specific approaches have been demonstrated to perform better than subject-independent ones. However, for pre-surgical diagnostics, the traditional method of obtaining a priori data to train subject-specific classifiers is not practical. We present an alternative method that works by adapting the threshold of a subject-independent to a specific subject based on feedback from the user.

  2. Technical specification for transferring National Pollutant Discharge Elimination System water data to the Oak Ridge Environmental Information System

    International Nuclear Information System (INIS)

    1996-11-01

    The primary goal of this technical specification is to meet the consolidated environmental data requirements defined by the Federal Facility (FFA) and the Tennessee Oversight Agreement (TOA) as they pertain to NPDES surface water data maintained in Oak Ridge, Tennessee, by the Department of Energy's Maintenance and Operations (M ampersand O) contractor Martin Marietta Energy Systems and prime contractors to DOE. This technical specification describes the organizational responsibilities for getting NPDES data into OREIS, describes the logical data transfer file required from NPDES, addresses business rules and submission rules, describes the physical data transfer file, addresses configuration control of this technical specification, and addresses required changes to the current OREIS data base structure due to the requirements of NPDES

  3. Improving non-technical skills (teamwork) in post-partum haemorrhage: A grouped randomised trial.

    Science.gov (United States)

    Letchworth, Pippa M; Duffy, Shane P; Phillips, Dan

    2017-10-01

    To determine the effect of a decision support technology on teamwork and associated non-technical (NTS) and technical skills when teams manage post-partum haemorrhage (PPH) in the simulated environment. Multidisciplinary (MDT) maternity teams were taught how to manage post partum haemorrhage. They were randomised to the intervention: using a decision support mobile digital platform or a control group. Each team managed a post-partum simulation, which was recorded and reviewed by assessors. Primary outcome measures to assess teams NTS were the validated Global Assessment of Obstetric Team Performance (GAOTP) and Clinical Teamwork Scale (CTS). Secondary outcome measures were the 'friends and family test', technical skills, and the System Usability Scale (SUS). Sample size estimation was calculated by using 80% power 5% significance two tailed test (p1=85% p2=40%) n=34. 38 teams from August 2014-February 2016, were recruited, technical issues with failure of recording equipment meant 4 teams were excluded from teamwork analysis (1 intervention 3 control). Teamwork improved across all domains with the intervention (using a decision support mobile digital platform) p technical skills were missed with the intervention (ptechnical skills were achieved. Assessors were more likely to recommend intervention teams 87.5% (77/88) than control teams 63.6% (56/88) p<0.01 to their friends or family. The SUS was 'Good' (69) becoming excellently 'Usable' (81.6) over the study period. We report a decision support system, which improved NTS when managing PPH. Lack of teamwork is often cited as the cause of failures in care and we report a usable technology that assists with and improves teamwork during an emergency. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. Participation in Training for Depression Care Quality Improvement: A Randomized Trial of Community Engagement or Technical Support.

    Science.gov (United States)

    Chung, Bowen; Ngo, Victoria K; Ong, Michael K; Pulido, Esmeralda; Jones, Felica; Gilmore, James; Stoker-Mtume, Norma; Johnson, Megan; Tang, Lingqi; Wells, Kenneth Brooks; Sherbourne, Cathy; Miranda, Jeanne

    2015-08-01

    Community engagement and planning (CEP) could improve dissemination of depression care quality improvement in underresourced communities, but whether its effects on provider training participation differ from those of standard technical assistance, or resources for services (RS), is unknown. This study compared program- and staff-level participation in depression care quality improvement training among programs enrolled in CEP, which trained networks of health care and social-community agencies jointly, and RS, which provided technical support to individual programs. Matched programs from health care and social-community service sectors in two communities were randomly assigned to RS or CEP. Data were from 1,622 eligible staff members from 95 enrolled programs. Primary outcomes were any staff trained (for programs) and total hours of training (for staff). Secondary staff-level outcomes were hours of training in specific depression collaborative care components. CEP programs were more likely than RS programs to participate in any training (p=.006). Within health care sectors, CEP programs were more likely than RS programs to participate in training (p=.016), but within social-community sectors, there was no difference in training by intervention. Among staff who participated in training, mean training hours were greater among CEP programs versus RS programs for any type of training (p<.001) and for training related to each component of depression care (p<.001) except medication management. CEP may be an effective strategy to promote staff participation in depression care improvement efforts in underresourced communities.

  5. PSA-based optimization of technical specifications for the Borssele nuclear power plant

    International Nuclear Information System (INIS)

    Seebregts, A.J.; Schoonakker, H.A.

    1996-01-01

    The Borssele Nuclear Power Plant (NPP) is a Siemens/KWU 472 MWe Pressurized Water Reactor which has been in operation since 1973. In 1989, a Probabilistic Safety Assessment (PSA) program was initiated to complement deterministic safety studies and operational experience in forming a plant safety concept. In 1993, the PSA-MER model was completed and used to determine the effects a package of proposed modifications would have on plant safety and risks to the environment. This model was used to start retrospective risks profile and allowed outage times (AOTs) analyses, which both concerned the calculation of the change in total core damage frequency (TCDF) given a change in configuration. The main problems identified and reported in this paper are: (i) How to calculate the change in TCDF (ΔTCDF)? (section 3); and (ii) How to set practical decision criteria and how to use the PSA as extension to Technical Specifications (TS) AOTs? (section 4). Finally, a pilot study was conducted in order to optimize surveillance test intervals (STIs) which are also part of the TS (section 5). (orig.)

  6. Reviewing PSA-based analyses to modify technical specifications at nuclear power plants

    International Nuclear Information System (INIS)

    Samanta, P.K.; Martinez-Guridi, G.; Vesely, W.E.

    1995-12-01

    Changes to Technical Specifications (TSs) at nuclear power plants (NPPs) require review and approval by the United States Nuclear Regulatory Commission (USNRC). Currently, many requests for changes to TSs use analyses that are based on a plant's probabilistic safety assessment (PSA). This report presents an approach to reviewing such PSA-based submittals for changes to TSs. We discuss the basic objectives of reviewing a PSA-based submittal to modify NPP TSs; the methodology of reviewing a TS submittal, and the differing roles of a PSA review, a PSA Computer Code review, and a review of a TS submittal. To illustrate this approach, we discuss our review of changes to allowed outage time (AOT) and surveillance test interval (STI) in the TS for the South Texas Project Nuclear Generating Station. Based on this experience gained, a check-list of items is given for future reviewers; it can be used to verify that the submittal contains sufficient information, and also that the review has addressed the relevant issues. Finally, recommended steps in the review process and the expected findings of each step are discussed

  7. Clinical improvement in psoriasis with specific targeting of interleukin-23

    DEFF Research Database (Denmark)

    Kopp, Tamara; Riedl, Elisabeth; Bangert, Christine

    2015-01-01

    Psoriasis is a chronic inflammatory skin disorder that affects approximately 2-3% of the population worldwide and has severe effects on patients' physical and psychological well-being. The discovery that psoriasis is an immune-mediated disease has led to more targeted, effective therapies; recent...... advances have focused on the interleukin (IL)-12/23p40 subunit shared by IL-12 and IL-23. Evidence suggests that specific inhibition of IL-23 would result in improvement in psoriasis. Here we evaluate tildrakizumab, a monoclonal antibody that targets the IL-23p19 subunit, in a three-part, randomized......, placebo-controlled, sequential, rising multiple-dose phase I study in patients with moderate-to-severe psoriasis to provide clinical proof that specific targeting of IL-23p19 results in symptomatic improvement of disease severity in human subjects. A 75% reduction in the psoriasis area and severity index...

  8. Improving the accessibility of an analytic and technical skills MCH toolbox.

    Science.gov (United States)

    Farel, Anita M; Paliulis, Sarah C

    2004-03-01

    To assess our analytic and technical skills website for accessibility and to make necessary corrections. We used commercially available software (Jaws and LIFT for Dreamweaver) and an individual with visual impairments to evaluate our self-instructional, analytic, and technical tools. We identified problems in tables, images, multimedia content, PDF files, and links. We repaired the site by using LIFT to make appropriate modifications to the website and tools. Improving accessibility is advantageous for all Internet users. In addition to responding to legislative mandates, accessible web design creates pages that are often more readable, easier to navigate, and faster to download. Improving the accessibility of websites that incorporate charts and graphs strengthens the ability of all members of the MCH workforce to address the core functions.

  9. Technical Meeting on Fast Reactors and Related Fuel Cycle Facilities with Improved Economic Characteristics. Working Material

    International Nuclear Information System (INIS)

    2013-01-01

    In recent years, engineering oriented work, rather than basic research and development (R&D), has led to significant progress in improving the economics of innovative fast reactors and associated fuel cycle facilities, while maintaining and even enhancing the safety features of these systems. Optimization of plant size and layout, more compact designs, reduction of the amount of plant materials and the building volumes, higher operating temperatures to attain higher generating efficiencies, improvement of load factor, extended core lifetimes, high fuel burnup, etc. are good examples of achievements to date that have improved the economics of fast neutron systems. The IAEA, through its Technical Working Group on Fast Reactors (TWG-FR) and Technical Working Group on Nuclear Fuel Cycle Options and Spent Fuel Management (TWG-NFCO), devotes many of its initiatives to encouraging technical cooperation and promoting common research and technology development projects among Member States with fast reactor and advanced fuel cycle development programmes, with the general aim of catalysing and accelerating technology advances in these fields. In particular the theme of fast reactor deployment, scenarios and economics has been largely debated during the recent IAEA International Conference on Fast Reactors and Related Fuel Cycles: Safe Technologies and Sustainable Scenarios, held in Paris in March 2013. Several papers presented at this conference discussed the economics of fast reactors from different national and regional perspectives, including business cases, investment scenarios, funding mechanisms and design options that offer significant capital and energy production cost reductions. This Technical Meeting on Fast Reactors and Related Fuel Cycle Facilities with Improved Economic Characteristics addresses Member States’ expressed need for information exchange in the field, with the aim of identifying the main open issues and launching possible initiatives to help and

  10. Technical specifications: Hope Creek Generating Station (Docket No. 50-354). Appendix A to License No. NPF-50

    International Nuclear Information System (INIS)

    1986-04-01

    Information is provided on the technical specifications for the Hope Creek Nuclear Power Station. Areas of interest discussed in this report include: safety limits and limiting safety system settings; limiting conditions for operation and surveillance requirements; design features; and administrative controls

  11. On-Line Monitoring of Instrument Channel Performance: Volume 3: Applications to Nuclear Power Plant Technical Specification Instrumentation

    International Nuclear Information System (INIS)

    Davis, E.; Rasmussen, B.

    2004-01-01

    This report is a guide for a technical specification change submittal and subsequent implementation of on-line monitoring for safety-related applications. This report is the third in a three-volume set. Volume 1, ''Guidelines for Model Development and Implementation'', presents the various tasks that must be completed to prepare models for and to implement an on-line monitoring system

  12. Technical Specifications, Seabrook Station, Unit 1 (Docket No. 50-443): Appendix ''A'' to License No. NPF-67

    International Nuclear Information System (INIS)

    1989-05-01

    The Seabrook Station, Unit 1 Technical Specifications were prepared by the US Nuclear Regulatory Commission to set forth the limits, operating conditions, and other requirements applicable to a nuclear reactor facility as set forth in Section 50.36 of 10 CFR Part 50 for the protection of the health and safety of the public

  13. Technical-evaluation report on the proposed technical-specification changes for the inservice surveillance of safety-related hydraulic and mechanical snubbers at the Millstone Nuclear Power Station, Unit 2 (Docket No. 50-336)

    International Nuclear Information System (INIS)

    Selan, J.C.

    1983-01-01

    This report documents the technical evaluation of the proposed Technical Specification changes to Limiting Conditions for Operation, Surveillance Requirements and Bases for safety-related hydraulic and mechanical snubbers at the Millstone Nuclear Power Station, Unit 2. The evaluation is to determine whether the proposed Technical Specifications are in conformance with the model Standard Technical Specification set forth by the NRC. A check list, Appendix A of this report, compares the licensee's submittal with the NRC requirements and includes Proposed Resolution of the Deviations

  14. Technical-evaluation report on the proposed technical-specification changes for the inservice surveillance of safety-related hydraulic and mechanical snubbers at the James A. Fitzpatrick Nuclear Power Plant (Docket No. 50-333)

    International Nuclear Information System (INIS)

    Selan, J.C.

    1983-01-01

    This report documents the technical evaluation of the proposed Technical Specification changes to Limiting Conditions for Operation, Surveillance Requirements and Bases for safety-related hydraulic and mechanical snubbers at the James A. FitzPatrick Nuclear Power Plant. The evaluation is to determine whether the proposed Technical Specifications are in conformance with the model Standard Technical Specification set forth by the NRC. A check list, Appendix A of this report, compares the licensee's submittal with the NRC requirements and includes Proposed Resolution of the Deviations

  15. Technical refinement and learning curve for attenuating neurapraxia during robotic-assisted radical prostatectomy to improve sexual function.

    Science.gov (United States)

    Alemozaffar, Mehrdad; Duclos, Antoine; Hevelone, Nathanael D; Lipsitz, Stuart R; Borza, Tudor; Yu, Hua-Yin; Kowalczyk, Keith J; Hu, Jim C

    2012-06-01

    While radical prostatectomy surgeon learning curves have characterized less blood loss, shorter operative times, and fewer positive margins, there is a dearth of studies characterizing learning curves for improving sexual function. Additionally, while learning curve studies often define volume thresholds for improvement, few of these studies demonstrate specific technical modifications that allow reproducibility of improved outcomes. Demonstrate and quantify the learning curve for improving sexual function outcomes based on technical refinements that reduce neurovascular bundle displacement during nerve-sparing robot-assisted radical prostatectomy (RARP). We performed a retrospective study of 400 consecutive RARPs, categorized into groups of 50, performed after elimination of continuous surgeon/assistant neurovascular bundle countertraction. Our approach to RARP has been described previously. A single-console robotic system was used for all cases. Expanded Prostate Cancer Index Composite sexual function was measured within 1 yr of RARP. Linear regression was performed to determine factors influencing the recovery of sexual function. Greater surgeon experience was associated with better 5-mo sexual function (p = 0.007) and a trend for better 12-mo sexual function (p = 0.061), with improvement plateauing after 250-300 cases. Additionally, younger patient age (both p<0.02) and better preoperative sexual function (<0.001) were associated with better 5- and 12-mo sexual function. Moreover, trainee robotic console time during nerve sparing was associated with worse 12-mo sexual function (p=0.021), while unilateral nerve sparing/non-nerve sparing was associated with worse 5-mo sexual function (p = 0.009). Limitations include the retrospective single-surgeon design. With greater surgeon experience, attenuating lateral displacement of the neurovascular bundle and resultant neurapraxia improve postoperative sexual function. However, to maximize outcomes, appropriate patient

  16. Integration of Hands-On Team Training into Existing Curriculum Improves Both Technical and Nontechnical Skills in Laparoscopic Cholecystectomy.

    Science.gov (United States)

    Caskey, Robert C; Owei, Lily; Rao, Raghavendra; Riddle, Elijah W; Brooks, Ari D; Dempsey, Daniel T; Morris, Jon B; Neylan, Christopher J; Williams, Noel N; Dumon, Kristoffel R

    Nontechnical skills are an essential component of surgical education and a major competency assessed by the ACGME milestones project. However, the optimal way to integrate nontechnical skills training into existing curricula and then objectively evaluate the outcome is still unknown. The aim of this study was to determine the effect laparoscopic team-based task training would have on the nontechnical skills needed for laparoscopic surgery. 9 PGY-1 residents underwent an established training curriculum for teaching the knowledge and technical skills involved in laparoscopic cholecystectomy. Initial training involved a didactic session, expert-led practice on a porcine model in a simulated operating room and laparoscopic skills practice on a virtual reality trainer. Residents then performed a laparoscopic cholecystectomy on the same porcine model as a preintervention test. Three to four months following this, residents were subjected to specific nontechnical skills training involving 2 simple team-based laparoscopic tasks. They then practiced a further 4 to 6 hours on the virtual reality trainer. A repeat postintervention laparoscopic cholecystectomy was then performed 3 to 4 months after nontechnical skills training. Both the preintervention and postintervention laparoscopic cholecystectomies were audiovisually recorded and then evaluated by 2 independent surgeons in a blinded fashion. Technical skills were assessed using objective structured assessment of technical skills (OSATS) and a technique specific rating scale (TRS) that we developed for laparoscopic cholecystectomy. Nontechnical skills were assessed using nontechnical skills for surgeons (NOTSS). Residents also completed a survey at the beginning and end of the training. Tertiary care, university based teaching institution. A total of 9 general surgery residents at the intern level. The mean OSATS score improved from 13.7 ± 1.24 to 26.7 ± 0.31 (p skills training for laparoscopic cholecystectomy that was

  17. Technical Meeting on Fast Reactors and Related Fuel Cycle Facilities with Improved Economic Characteristics. Presentations

    International Nuclear Information System (INIS)

    2013-01-01

    The objectives of the meeting were: • To identify the main issues and technical features that affect capital and energy production costs of fast reactors and related fuel cycle facilities; • To present fast reactor concepts and designs with enhanced economic characteristics, as well as innovative technical solutions (components, subsystems, etc.) that have the potential to reduce the capital costs of fast reactors and related fuel cycle facilities; • To present energy models and advanced tools for the cost assessment of innovative fast reactors and associated nuclear fuel cycles; • To discuss the results of studies and ongoing R&D activities that address cost reduction and the future economic competitiveness of fast reactors; • To identify research and technology development needs in the field, also in view of new IAEA initiatives to help and support Member States in improving the economic competitiveness of fast reactors and associated nuclear fuel cycles

  18. TECHNICAL AND FINANCIAL ASSESSMENT OF ORGANIZATIONAL IMPROVEMENTS OF SELECTED BUSINESS ENTITIES OF FOOD CHAIN MANAGEMENT

    Directory of Open Access Journals (Sweden)

    Małgorzata Krotowska

    2016-03-01

    Full Text Available The aim of the article was technical and economic assessment of organizational improvements and use of resources of the examined business entities within the frames of their economic activity. The measurement of economic effi ciency was done with the use of commonly accepted profi tability indices (ROE, profi t margin and RONA. The technical assessment was based on the DEA method, taking into account the model: CRS, VRS and the scale of production. The variables applied in the model w ere operating incomes, as well as expenditures, i.e. UR area, labour input, value of fi xed assets and expenditure connected with energy and materials consumption. The research results proved that there were not signifi cant diff erences between the examined groups (Z and N as far as calculated indices were concerned.

  19. Technical Meeting on Fast Reactors and Related Fuel Cycle Facilities with Improved Economic Characteristics. Working Material

    International Nuclear Information System (INIS)

    2013-01-01

    The objectives of the meeting were: - To identify the main issues and technical features that affect capital and energy production costs of fast reactors and related fuel cycle facilities; - To present fast reactor concepts and designs with enhanced economic characteristics, as well as innovative technical solutions (components, subsystems, etc.) that have the potential to reduce the capital costs of fast reactors and related fuel cycle facilities; - To present energy models and advanced tools for the cost assessment of innovative fast reactors and associated nuclear fuel cycles; - To discuss the results of studies and on-going R&D activities that address cost reduction and the future economic competitiveness of fast reactors; and - To identify research and technology development needs in the field, also in view of new IAEA initiatives to help and support Member States in improving the economic competitiveness of fast reactors and associated nuclear fuel cycles

  20. Limited intervention improves technical skill in focus assessed transthoracic echocardiography among novice examiners

    Directory of Open Access Journals (Sweden)

    Frederiksen Christian

    2012-08-01

    Full Text Available Abstract Background Previous studies addressing teaching and learning in point-of-care ultrasound have primarily focussed on image interpretation and not on the technical quality of the images. We hypothesized that a limited intervention of 10 supervised examinations would improve the technical skills in Focus Assessed Transthoracic Echocardiography (FATE and that physicians with no experience in FATE would quickly adopt technical skills allowing for image quality suitable for interpretation. Methods Twenty-one physicians with no previous training in FATE or echocardiography (Novices participated in the study and a reference group of three examiners with more than 10 years of experience in echocardiography (Experts was included. Novices received an initial theoretical and practical introduction (2 hours, after which baseline examinations were performed on two healthy volunteers. Subsequently all physicians were scheduled to a separate intervention day comprising ten supervised FATE examinations. For effect measurement a second examination (evaluation of the same two healthy volunteers from the baseline examination was performed. Results At baseline 86% of images obtained by novices were suitable for interpretation, on evaluation this was 93% (p = 0.005. 100% of images obtained by experts were suitable for interpretation. Mean global image rating on baseline examinations was 70.2 (CI 68.0-72.4 and mean global image rating after intervention was 75.0 (CI 72.9-77.0, p = 0.0002. In comparison, mean global image rating in the expert group was 89.8 (CI 88.8-90.9. Conclusions Improvement of technical skills in FATE can be achieved with a limited intervention and upon completion of intervention 93% of images achieved are suitable for clinical interpretation.

  1. Combining specificity determining and conserved residues improves functional site prediction

    Directory of Open Access Journals (Sweden)

    Gelfand Mikhail S

    2009-06-01

    Full Text Available Abstract Background Predicting the location of functionally important sites from protein sequence and/or structure is a long-standing problem in computational biology. Most current approaches make use of sequence conservation, assuming that amino acid residues conserved within a protein family are most likely to be functionally important. Most often these approaches do not consider many residues that act to define specific sub-functions within a family, or they make no distinction between residues important for function and those more relevant for maintaining structure (e.g. in the hydrophobic core. Many protein families bind and/or act on a variety of ligands, meaning that conserved residues often only bind a common ligand sub-structure or perform general catalytic activities. Results Here we present a novel method for functional site prediction based on identification of conserved positions, as well as those responsible for determining ligand specificity. We define Specificity-Determining Positions (SDPs, as those occupied by conserved residues within sub-groups of proteins in a family having a common specificity, but differ between groups, and are thus likely to account for specific recognition events. We benchmark the approach on enzyme families of known 3D structure with bound substrates, and find that in nearly all families residues predicted by SDPsite are in contact with the bound substrate, and that the addition of SDPs significantly improves functional site prediction accuracy. We apply SDPsite to various families of proteins containing known three-dimensional structures, but lacking clear functional annotations, and discusse several illustrative examples. Conclusion The results suggest a better means to predict functional details for the thousands of protein structures determined prior to a clear understanding of molecular function.

  2. NPSAG/NKS: Interpretation and evaluation of the technical specification criteria

    Energy Technology Data Exchange (ETDEWEB)

    Baeckstroem, O.; Haeggstroem, A. (Relcon Scandpower AB, Sundbyberg (Sweden)); Simola, K. (VTT (Finland))

    2008-07-15

    The use of risk-informed methods has been discussed since the late 1980s. in the Nordic countries. However, at that time the industry and authorities were not ready for the use of these methods and the use of them have been limited. The common understanding right now is that the industry and authorities are ready for adoption of risk-informed strategies, and the use of risk informed methods in daily operation at the nuclear power plants (NPPs) as well as for long term evaluation and definition of rules and regulations is increasing. The authorities are strengthening the rules and regulations with regard to redundancy and diversification in the safety systems. There are several ongoing projects at the NPPs, such as modernization, power upgrade etc. These projects will require modification of the Technical Specifications (TS). The requirements on a risk analysis to verify exceptions will be a natural part of the TS update. To summarize; there are both activities and trends at the plants that will result in TS changes (modernizations, increase of electrical power, risk informed strategies). At the same time, authorities are increasing the requirements on risk informed evaluation of the TS. TS evaluation from a risk point of view raises several questions: 1) How shall the TS conditions be evaluated? 2) What aspects shall be taken into consideration? 3) Can a prolonged/shortened surveillance test interval (STI) or allowed outage time (AOT) affect the experienced importance of the equipment? 4) What do the conditions in the TS with regard to AOT really represent? Are they conditions that shall be used when spare part storage and/or maintenance strategies are developed or do they represent how a real situation (unavailable component) shall be managed? To form an idea of the opinion on these questions phase 1 of the project is based on a literature study and interviews with persons at the Swedish and Finnish utilities and authorities. A short background to the current TS

  3. Guidance to risk-informed evaluation of technical specifications using PSA

    Energy Technology Data Exchange (ETDEWEB)

    Baeckstroem, O.; Haeggstroem, A. (Scandpower AB, Stockholm (Sweden)); Maennistoe, I. (VTT, Helsingfors (Finland))

    2010-04-15

    This report presents guidance for evaluation of Technical Specification conditions with PSA. It covers quality in PSA, how to verify that the PSA model is sufficiently robust and sufficiently complete and general requirements on methods. Acceptance criteria for evaluation of changes in the TS conditions are presented. As the probabilistic safety assessment (PSA) has developed over the years, it has demonstrated to constitute a useful tool for evaluating many aspects of the TS from a risk point of view. and in that way making the PSAs as well as the decision tools better. This also means that it will be possible to take credit for safety system overcapacity as well as inherent safety features and strength of non-safety classed systems. However, PSA is only one of the tools that shall be used in an evaluation process of TS changes (strengthening/relaxation). PSA is an excellent tool to be used to verify the importance, and thereby possibly relaxation, of TS requirements. But, since PSA is only one tool in the evaluation, it is not sufficient in itself for defining which equipment that shall or shall not have TS requirements. The purpose of this guidance document is to provide general requirements, requirements on methods and acceptance criteria on risk-informed evaluation of TS changes based on PSA. The purpose is not to provide a single solution. As part of the review of the TS conditions this guidance specify requirements on: - Quality verification of the PSA model; - Verification that the PSA model is sufficiently robust with regard to SSCs for which requirements both are and are not defined by the TS; - Verification that the SSCs, for which TS demands are to be evaluated, are modelled in a sufficient manner; - Methods for performing the evaluation; - Which evaluation criteria that shall be used (and how that is verified to be correct); - Acceptance criteria: This guidance also briefly discusses the documentation of the analysis of the TS changes. This guidance

  4. REHEARSAL Using Patient-Specific Simulation to Improve Endovascular Efficiency.

    Science.gov (United States)

    Wooster, Mathew; Doyle, Adam; Hislop, Sean; Glocker, Roan; Armstrong, Paul; Singh, Michael; Illig, Karl A

    2018-04-01

    To determine whether rehearsal using patient-specific information loaded onto an endovascular simulator prior to carotid stenting improves procedural efficiency and outcomes. Patients scheduled for carotid artery stenting who had adequate preoperative computed tomography (CT) imaging were considered for enrollment. After obtaining informed consent, patients were randomized to control versus rehearsal groups. Those in the rehearsal group had their CT scans loaded into an endovascular simulator (Angio Mentor) followed by case rehearsal by the attending on the simulator within 24 hours prior to the procedure; control patients underwent routine carotid stenting without rehearsal. Contrast usage, fluoroscopy time, and timing of procedural steps were recorded by a blinded observer during the actual case to determine benefit. Fifteen patients were enrolled, with 6 patients randomized to the rehearsal group and 9 to the control. All measures showed improvement in the rehearsal group: Mean contrast volume (59.2 vs 76.9 mL), fluoroscopy time (11.4 vs 19.4 minutes), overall operative time (31.9 vs 42.5 minutes), time to common carotid sheath placement (17.0 vs 23.3 minutes), and total carotid sheath dwell time (14.9 vs 19.2 minutes) were all lower (more favorable) in the rehearsal group. The study was terminated early due to the lack of simulator access, and all P values were thus greater than .05 due to the lack of power. No strokes or other adverse events occurred in either group. Case-specific simulator rehearsal using patient-specific imaging prior to carotid stenting is associated with numerically less contrast usage, operative time, and radiation exposure, although this study was underpowered.

  5. 77 FR 16869 - Proposed Models for Plant-Specific Adoption of Technical Specifications Task Force Traveler TSTF...

    Science.gov (United States)

    2012-03-22

    ... system. This TS improvement is part of the consolidated line item improvement process (CLIIP). Additional... NRC-2012-0071. NRC's Agencywide Documents Access and Management System (ADAMS): You may access... continuous hours every 31 days, would be changed to require at least 15 continuous minutes of heater...

  6. TECHNICAL ASPECTS REGARDING THE IMPROVEMENT OF AEROSPACE AIR DEFENSE VECTORS’ PERFORMANCES

    Directory of Open Access Journals (Sweden)

    Vasile SANDRU

    2013-01-01

    Full Text Available Confronted with the spectacular evolution of the aircraft and other aerial vehicles, the systems destined to combat them, especially Surface-to-Air Missile Systems (SAMS, went through an accelerated loss of their performance. The financial crisis has forced an extension of the system operation even if the system is outdated. Therefore, a new modernized version has been designed. Many times, it is better to improve an existing system than to buy a new one. This article describes the diversity of SAMS’s challenges, involving a decrease in time regarding their number. The types of challenges can be divided in two categories: technical and institutional ones. The technical challenges can be also divided in two categories: deterioration of material and obsolescence. The classes of material that present interest for us are aerodynamic vector structure, propulsion, and special systems. From an institutional point of view, the main problems are: cost versus performance and cost versus the remaining lifetime (technical resource of the air defense system. The article finishes with conclusions that support the possibility and necessity of a SAMS upgrade, given the change of the threats characteristics.

  7. A technical system to improve the operational monitoring of the Zaporozhye nuclear power plant

    Energy Technology Data Exchange (ETDEWEB)

    Beyer, M.; Carl, H.; Nowak, K. [Technischer Ueberwachungsverein Rheinland, Koeln (Germany). Inst. for Nuclear Engineering and Radiation Protection; Schumann, P.; Seidel, A.; Weiss, F.P.; Zschau, J.

    1998-10-01

    As part of the programme implemented by the German Ministry of Environment, Nature Conservation and Reactor Safety to cooperate with the Central and Eastern European States (CEES) and the Commonwealth of Independent States (CIS) in the area of nuclear safety, a technical system to improve operational monitoring has been designed, specified and established since 1992 as a pilot project in the Zaporozhye/Ukraine nuclear power plant by Forschungszentrum Rossendorf and Technischer Ueberwachungsverein Rheinland with a significant contribution from the State Scientific and Technical Centre of the Ukrainian supervisory authority. The technical system complements existing operational checking and monitoring facilities by including modern means of information technology. It enables a continuous monitoring of the state of unit 5 in normal operation and in cases of anomalies or incidents so that when recognisable deviations from the regular plant operation occur, the Ukrainian supervisory authority can immediately inquire and if necessary impose conditions on the operator. The radiological and meteorological parameters at the nuclear power plant location are monitored to the extent necessary to assess the current radiation situation and to implement efficient emergency management measures. (orig.)

  8. The Development of Technical and Vocational Education in Malaysia--A Case Study in Quality Improvement. Case Studies on Technical and Vocational Education in Asia and the Pacific.

    Science.gov (United States)

    Hee, Tieng Fok

    The economic profile of Malaysia has changed from an economy mainly based on agriculture and the production of tin ore to a more balanced economy with continuing growth in the manufacturing and industrial sectors. Educational programs need to be upgraded and improved, particularly the direction and development of technical and vocational education…

  9. The Development of Technical and Vocational Education for Vietnam--A Case Study in Quality Improvement. Case Studies on Technical and Vocational Education in Asia and the Pacific.

    Science.gov (United States)

    Nguyen, Duong

    This report provides a general overview of technical and vocational education in Vietnam, with information on the country's economy, climate, population, and culture. It summarizes the history and present practices of these types of education in the country, and suggests measures to improve the quality of teachers and instructors. Some of the…

  10. THE MODEL OF TEACHING A FOREIGN LANGUAGE FOR SPECIFIC PURPOSES IN A TECHNICAL UNIVERSITY

    Directory of Open Access Journals (Sweden)

    Cherkashina, E.I.

    2017-06-01

    Full Text Available The article presents a new model of a linguistic educational process that can be implemented in the practice of teaching a foreign language in a technical university. The proposed model takes into account the characteristic features of mindset of students of technical universities and faculties, and it constitutes a matrix with a binary opposition. Filled-in matrix cells represent a structure of the language knowledge content in a visual form. Knowledge of the system organization of a language helps the students to understand "language in action" in the way that corresponds to their left hemisphere mindset. The knowledge of the dominant hemisphere cerebration peculiarities of the students of technical specializations (engineering physicists lets us model a lingvo-educational process in a non-linguistic university. A complex linking of lingvo-didactic components makes the teachers of foreign language take into consideration the results of the research in the field of functional interhemispheric asymmetry of the brain. The emphasis on the abilities of the left hemisphere dominating among the students has to change the approach of the teachers of foreign languages to the organization of the linguistic educational process in a technical university. It is also important to consider that the skills which led the life in the information age remain necessary, but they alone are no longer sufficient for personal self-realization in the new conceptual age.

  11. Factors of Quality Improvement of the Foreign Language Teaching in Technical University

    Directory of Open Access Journals (Sweden)

    Ira R. Agasieva

    2017-03-01

    Full Text Available In the article the problem of quality of teaching and knowledge of the English language has been considered. The factors that influence the improvement of the quality of teaching and knowledge of the English language in a technical college, the use of various methods of enhancing the quality of teaching and knowledge of the English language has been analyzed. It has been distinguished the necessity of taking into account the factors such as emotional maturity of the student, the desire for success, student cognitive style, its consistency and independence.

  12. THE PROSPECTS FOR IMPROVING THE TECHNICAL STATE OF ROLLING STOCK ON THE RAILWAYS OF UKRAINE

    Directory of Open Access Journals (Sweden)

    O. V. Ponomarenko

    2017-02-01

    Full Text Available Purpose. One of the main conditions of the effective and high-quality organization of rail hauling is availability of modern rolling stock. However, the analysis of technical condition confirms its considerable moral and physical deterioration. The main purpose of the article is search of possible ways of improvement of technical condition of the existing car fleet on the railroads of Ukraine. Methodology. The current state of a rail transport not fully meets the modern requirements. For the last decades updating of fixed assets has been provided generally at the expense of own means of the railroads and satisfied the need for capital investments only for 5-6 percent. At the same time, actually since declaration of independence of Ukraine the price growth rates for the products consumed by the railroads exceeded the fare growth rates that did not allow to update in necessary amount and to improve technical condition of the rolling stock. Findings. The article presents the analysis of freight rolling stock of Ukrainian Railways, which showed unsatisfactory condition of the cars. The railway industry today works on the old principles, which do not correspond to the modern world trends in organization of work of railway transport, contribute to the inefficiency of its functioning and impede further development, constraining the inflow of investment to this industry, hamper cooperation with private companies. Insufficient funding and imperfect system of repair and maintenance inhibit the development and reduce the competitiveness of railway transport of Ukraine. However, the implementation of strategic directions of development of the transport sector, a review of the above constraints and using the experience of advanced countries will steer the rail transport out of the crisis. Originality. The authors presented comprehensive consideration of issues to improve the car maintenance system while extending the life of their operation. Practical value

  13. Multifunctional Beta Ti Alloy with Improved Specific Strength

    Science.gov (United States)

    Park, Chan Hee; Hong, Jae-Keun; Lee, Sang Won; Yeom, Jong-Taek

    2017-12-01

    Gum metals feature properties such as ultrahigh strength, ultralow elastic modulus, superelasticity, and superplasticity. They are composed of elements from Groups 4 and 5 of the periodic table and exist when the valance electron concentration (\\overline{e/a}) is 4.24; the bond order (\\overline{Bo}) is 2.87; and the "d" electron-orbital energy level (\\overline{Md}) is 2.45 eV. Typical compositions include Ti-23Nb-2Zr-0.7Ta-O and Ti-12Ta-9Nb-6Zr-3 V-O, which contain large amounts of heavy Group-5 elements such as Nb and Ta. In the present study, to improve the specific strength of a multifunctional beta Ti alloy, three alloys (Ti-20Nb-5Zr-1Fe-O, Ti-12Zr-10Mo-4Nb-O, and Ti-24Zr-9Cr-3Mo-O) were designed by satisfying the above three requirements while adding Fe, Mo, and Cr, which are not only lightweight but also have strong hardening effects. Microstructural and mechanical property analyses revealed that Ti-20Nb-5Zr-1Fe-O has a 25% higher specific strength than gum metal while maintaining an ultralow elastic modulus.

  14. SPECIFICITY AND TRENDS IN IMPROVEMENT OF TRACTOR TRAIN BRAKING DYNAMICS

    Directory of Open Access Journals (Sweden)

    G. A. Tayanovsky

    2015-01-01

    Full Text Available The paper considers an important problem in improvement of  braking dynamics potential as part of the overall tractor train dynamics consisting of  an all-wheel drive tractor and heavy-duty trailers which are either locally manufactured or developed with the participation of the paper’s authors. The trailers have a mechanical drive for their wheels from the tractor engine. The trains are intended for transportation peat, organic fertilizers and various loads in  forest exploitation and under other complicated soil and climatic and road conditions where there is justified necessity to activate the trailer wheels.Methodological tools have been developed with the purpose to analyze an influence of the blocked inter-double-reduction axle drive of an active tractor train on distribution of braking forces in double-reduction axles with due account of the heavy-duty peat trailer specificity. Theoretical provisions for wheeled vehicles have been developed with regard to the braking application specificity of active tractor trains with mechanical multi-path drive for wheels of a multi-double-reduction axle propulsion device. The paper presents calculation and theoretical data in order to estimate  distribution of specific braking forces in the double-reduction axle links of the active tractor train when the blocked inter-double-reduction axle drive of the tractor and trailer wheels is switched on and also in the case when the tractor engine is involved in braking process and a clutch coupling is switched-on.Sequence of the calculation formula has been completely carried out in the paper. They represent clear design and operational parameters of the active tractor train. Such approach has made it possible to realize them in the form of a software application which is convenient for analysis of the braking process pertaining to the investigated objects in order to select means for improvement of braking dynamics, rational parameters of multi

  15. Technical specification for design, fabrication, use and maintenance of tie-down system

    International Nuclear Information System (INIS)

    Curcuruto, S.; Palmieri, G.; Trivelloni, S.; Orsini, A.

    1993-01-01

    IAEA Safety Series ndeg6 states that to ensure compliance with the Regulation the programs of quality assurance must be put in practice either for design, manufacture, testing, documentation, use and maintenance and inspection of all packages or for transport and intransit storage operations. Therefore in view of a standardization coming from Q.A. criteria, the Italian Competent Authority for transport of radioactive material (ENEA-DISP) is preparing a technical guide for the design, construction, use and maintenance of tie-down system for road transport of packages containing radioactive materials. The paper shows some phases of the program started by ENEA-DISP for the redaction of the technical guide. (J.P.N.)

  16. Improvement of the test quality for specific test problems. Proceedings

    International Nuclear Information System (INIS)

    2011-01-01

    This proceedings CD discusses the many factors that are relevant in nearly all tests, as well as their effects on the validity of the test result. Interfaces with technical rules, staff qualification, POD, and validation of test results by supplementary techniques are presented as well. Three of the 17 papers are available as separate records in the ENERGY database. [de

  17. Technical Specifications of Structural Health Monitoring for Highway Bridges: New Chinese Structural Health Monitoring Code

    Directory of Open Access Journals (Sweden)

    Fernando Moreu

    2018-03-01

    Full Text Available Governments and professional groups related to civil engineering write and publish standards and codes to protect the safety of critical infrastructure. In recent decades, countries have developed codes and standards for structural health monitoring (SHM. During this same period, rapid growth in the Chinese economy has led to massive development of civil engineering infrastructure design and construction projects. In 2016, the Ministry of Transportation of the People’s Republic of China published a new design code for SHM systems for large highway bridges. This document is the first technical SHM code by a national government that enforces sensor installation on highway bridges. This paper summarizes the existing international technical SHM codes for various countries and compares them with the new SHM code required by the Chinese Ministry of Transportation. This paper outlines the contents of the new Chinese SHM code and explains its relevance for the safety and management of large bridges in China, introducing key definitions of the Chinese–United States SHM vocabulary and their technical significance. Finally, this paper discusses the implications for the design and implementation of a future SHM codes, with suggestions for similar efforts in United States and other countries.

  18. Technical specifications of air handling system of the inspection of a field

    International Nuclear Information System (INIS)

    Kim, Seon Duk; Bang, Hong Sik; Oh, Yon Woo

    2002-07-01

    A T.A.B(Testing, Adjusting and Balancing) technique, the basic technique of air handling facility, is one of the essential technical items which workers in charge of operation of facilities have to acquire. Especially, through scientific and reasonable inspective procedures, the reduction of energy and guarantee of designed skill have become influential important problems in our time rather than in the past days. Entrepreneurs have required more thorough verify of performances and procedure of test in order to raise the investment efficiency and reduce expenditure. For that reason, I hope that co-operator acquire objective and substantial knowledges about air handling facility so that they are helped from them

  19. Objectives, specification and elaboration of technical scenarios for emergency drills involving a French PWR

    International Nuclear Information System (INIS)

    Duco, J.

    1989-08-01

    All safety measures taken during the design, the construction and the operation of a nuclear power plant decrease to an extremely low level the probability of an accident with unacceptable consequences for the public. Nevertheless, for the case such an accident should be initiated, emergency plans have been elaborated: the on-site emergency plan to protect the plant personnel, terminate the accident and mitigate the consequences; the short-term and longer-term off-side emergency plans to protect the public and organise the return to acceptable living conditions. The appropriateness and preparedness of such plans have to be checked regularly by means of drills, which may be restricted to technical aspects concerning the nuclear units, or involve all actors, i.e. the utility, all the branches of the administration concerned and a media simulation. Some aspects of the choice of goals and preparation of drills are presented and illustrated by the national EPAULE exercice in 1987. Technically speaking, the drills have proved the validity of the current organization and evidenced its operability: uncertainties remain as regards the actual vs expected behavior of the population, due to emotional aspects linked to the lack of direct perception of the degree of danger and to the information received in an actual nuclear emergency

  20. Core trainee boot camp-A method for improving technical and non-technical skills of novice surgical trainees. A before and after study.

    Science.gov (United States)

    Bamford, R; Langdon, L; Rodd, C A; Eastaugh-Waring, S; Coulston, J E

    2018-04-10

    The transition to surgical training can be a stressful time for trainees and is most evident during national handover periods where new graduates start and senior trainees rotate to new programmes. During this time, patient mortality can increase and Hospital efficiency reduces. This influence is compounded by the impact of working time directives. Intensive, simulation rich training programmes or "Boot Camps" have been postulated as a solution. This article highlights the development of a surgical boot camp for novice surgical trainees and the impact this can have on training. A novel surgical boot camp was developed for all trainees within a surgical training region including nine acute NHS trusts. Participating cohort of trainees completed pre and post course questionnaires to assess technical and non-technical skills. 25 trainees attended and completed the pre and post boot camp questionnaire. Significant improvements were seen with technical skills (p = 0.0429), overall non-technical skills (p skills (p = 0.005) and outpatient skill (p = 0.002). Trainees reported significantly increased ability to assess and manage a critically unwell patient (p = 0.001) and a trauma patient (p = 0.001). 96% of trainees have utilised the skills they learnt on Boot Camp and all trainees would recommend it as an induction programme. Surgical Boot Camps offer a timely chance to develop technical and non-technical skills whilst enhancing a trainee's confidence and knowledge and reduce the patient safety impact of the handover period. Copyright © 2018. Published by Elsevier Ltd.

  1. Improving Site-Specific Radiological Performance Assessments - 13431

    International Nuclear Information System (INIS)

    Tauxe, John; Black, Paul; Catlett, Kate; Lee, Robert; Perona, Ralph; Stockton, Tom; Sully, Mike

    2013-01-01

    An improved approach is presented for conducting complete and defensible radiological site-specific performance assessments (PAs) to support radioactive waste disposal decisions. The basic tenets of PA were initiated some thirty years ago, focusing on geologic disposals and evaluating compliance with regulations. Some of these regulations were inherently probabilistic (i.e., addressing uncertainty in a quantitative fashion), such as the containment requirements of the U.S. Environmental Protection Agency's (EPA's) 40 CFR 191, Environmental Radiation Protection Standards for Management and Disposal of Spent Nuclear Fuel, High-Level and Transuranic Radioactive Wastes, Chap. 191.13 [1]. Methods of analysis were developed to meet those requirements, but at their core early PAs used 'conservative' parameter values and modeling approaches. This limited the utility of such PAs to compliance evaluation, and did little to inform decisions about optimizing disposal, closure and long-term monitoring and maintenance, or, in general, maintaining doses 'as low as reasonably achievable' (ALARA). This basic approach to PA development in the United States was employed essentially unchanged through the end of the 20. century, principally by the U.S. Department of Energy (DOE). Performance assessments developed in support of private radioactive waste disposal operations, regulated by the U.S. Nuclear Regulatory Commission (NRC) and its agreement states, were typically not as sophisticated. Discussion of new approaches to PA is timely, since at the time of this writing, the DOE is in the midst of revising its Order 435.1, Radioactive Waste Management [2], and the NRC is revising 10 CFR 61, Licensing Requirements for Land Disposal of Radioactive Waste [3]. Over the previous decade, theoretical developments and improved computational technology have provided the foundation for integrating decision analysis (DA) concepts and objective-focused thinking, plus a Bayesian approach to

  2. Improving physical health international students enrolled in a technical college in Baikal region

    Directory of Open Access Journals (Sweden)

    M.M. Kolokoltsev

    2014-02-01

    Full Text Available Purpose : to improve the physical health of foreign students enrolled in a technical college Baikal region using an extended motor mode. Material : in the experiment participated 57 students attending the training of South-East Asia, 74 - from Central Asia and 455 - Slavs, natives of the Irkutsk region. Results : it was found poor fitness and low functional performance among foreign students. For this purpose they had used advanced motoring. It included, besides training curriculum additional group activities in the form of sports, participating in sports events and guided independent study physical education. Conclusion : the end of follow foreign students involved in the extended motor mode, significantly outperform their peers engaged on normal functional parameters (heart rate, a test with 20 squats, the recovery time after exercise, dynamometry hands, breath tests, adaptive capacity as well as motor qualities.

  3. Echocardiography Practice: Insights into Appropriate Clinical Use, Technical Competence and Quality Improvement Program

    Science.gov (United States)

    Kossaify, Antoine; Grollier, Gilles

    2014-01-01

    Echocardiography accounts for nearly half of all cardiac imaging techniques. It is a widely available and adaptable tool, as well as being a cost-effective and mainly a non-invasive test. In addition, echocardiography provides extensive clinical data, which is related to the presence or advent of different modalities (tissue Doppler imaging, speckle tracking imaging, three-dimensional mode, contrast echo, etc.), different approaches (transesophageal, intravascular, etc.), and different applications (ie, heart failure/resynchronization studies, ischemia/stress echo, etc.). In view of this, it is essential to conform to criteria of appropriate use and to keep standards of competence. In this study, we sought to review and discuss clinical practice of echocardiography in light of the criteria of appropriate clinical use, also we present an insight into echocardiographic technical competence and quality improvement project. PMID:24516342

  4. It's not hype, it's communication: Using public relations techniques to improve your technical messages

    Energy Technology Data Exchange (ETDEWEB)

    Martell, P.J.

    1990-01-01

    Technical communicators are concerned that if they employ public relations (PR) techniques, they somehow compromise their work. They believe PR equates with type. However, to those of us in the field, PR means simply how people relate. Knowing PR techniques gives one a better understanding of human factors and interactions; using the techniques improves the chances for communication to occur. If technical communications are willing to learn PR techniques, they will gain strong tools to use to strengthen their messages.

  5. Technologies for improving the availability and reliability of current and future water cooled nuclear power plants. Proceedings of a technical committee meeting

    International Nuclear Information System (INIS)

    1998-11-01

    One of the activities of the IAEA is to provide all Member States with an international source of balanced, objective information on advanced in technology for water cooled reactors. Since the global nuclear industry has a common interest in improving plant availability and reliability to assure specific individual plant and country perspective as well as to have an image of well managed competitive industry, the IAEA held a Technical Committee Meeting on Technologies for Improving the Availability and Reliability of Current and Future Water Cooled Nuclear Power Plants in September 1997. The basic aim to was to identify, review and exchange information on international developments in technologies for achieving high availability and reliability and to suggest areas where further technical advances could contribute to improvement of performance. Designs for future plants were presented in the context of how they can accommodate both the organizational and technical means for reaching even higher levels of performance. This proceedings contains the contributed papers presented at this Meeting each with a separate abstract. Four sessions were concerned with: policies, practices and procedures for achieving high reliability and availability; improving availability and reliability through better use of today's technologies; recent advances in technologies for improving availability and reliability; achieving high availability for new plants

  6. Validity of multiple stress creep recovery (MSCR) test for DOTD asphalt binder specification : technical summary.

    Science.gov (United States)

    2017-09-01

    Higher traffic coupled with heavier loads led the asphalt industry to introduce polymer-modified binders to enhance the durability and strength of hot mix asphalt (HMA) pavements. When the Superpave Performance Graded (PG) binder specification (AASHT...

  7. Technical improvements for the dynamic measurement of general scour and landslides

    Science.gov (United States)

    Chung Yang, Han; Su, Chih Chiang

    2017-04-01

    Disasters occurring near riverbeds, such as landslides, earth slides, debris flow, and general scour, are easily caused by flooding from typhoons. The occurrence of each type of disaster involves a process, so if a disaster event can be monitored in real time, hazards can be predicted, thereby enabling early warnings that could reduce the degree of loss engendered by the disaster. The study of technical improvements for the dynamic measurement of general scour and landslides could help to release these early warnings. In this study, improved wireless tracers were set up on site to ensure the feasibility of the improved measurement technology. A wireless tracer signal transmission system was simultaneously set up to avoid danger to surveyors caused by them having to be on site to take measurements. In order to understand the real-time dynamic riverbed scouring situation, after the flow path of the river was confirmed, the sites for riverbed scouring observation were established at the P30 pier of the Dajia River Bridge of National Highway No. 3, and approximately 100 m both upstream and downstream (for a total of three sites). A rainy event that caused riverbed erosion occurred in May 2015, and subsequently, Typhoons Soudelor, Goni, and Dujuan caused further erosion in the observed area. The results of the observations of several flood events revealed that wireless tracers can reflect the change in riverbed scour depth caused by typhoons and flooding in real time. The wireless tracer technique can be applied to real-time dynamic scouring observation of rivers, and these improvements in measurement technology could be helpful in preventing landslides in the future.

  8. Improvement of technical training of sportswomen in rhythmic gymnastics by means of acrobatics at the stage of preliminary basic preparation

    Directory of Open Access Journals (Sweden)

    Petro Kyzim

    2016-10-01

    Full Text Available Purpose: to prove experimentally the technique of improvement of technical training of sportswomen in rhythmic gymnastics by means of acrobatics at the stage of preliminary basic preparation. Material & Methods: the following methods of the research were used: analysis and synthesis of references, pedagogical observations, pedagogical testing, pedagogical experiment, method of expert assessment (qualimetry, methods of mathematical statistics. Results: the level of technical skill of performance of pre-acrobatic elements by sportswomen of rhythmic gymnastics before carrying out the pedagogical experiment is determined. The dynamics of indicators of the level of technical preparedness of sportswomen of rhythmic gymnastics is defined. Conclusions: it is established that additional resources of acrobatics influence significantly the level of technical preparedness of sportswomen of rhythmic gymnastics at the stage of preliminary basic preparation.

  9. Knowledge Sharing for Common Understanding of Technical Specifications Through Artifactual Culture

    DEFF Research Database (Denmark)

    Zahedi, Mansooreh; Babar, Muhammad Ali

    2014-01-01

    specification knowledge. We also present the practices that make up the artifact-based knowledge sharing system in the studied case. Finally, we shed some light on the caveats of knowledge sharing practices adopted by the studied company. The findings can provide useful insights into the artifact...

  10. A Preliminary Investigation of General and Technique-specific Assessments for the Evaluation of Laparoscopic Technical Skills.

    Science.gov (United States)

    Vergis, Ashley; Steigerwald, Sarah

    2017-10-07

    Background  Both general and technique-specific assessments of technical skill have been validated in surgical education. The purpose of this study was to assess the correlation between the objective structured assessment of technical skills (OSATS) and the global operative assessment of laparoscopic skills (GOALS) rating scales using a high-fidelity porcine laparoscopic cholecystectomy model. Methods Post-graduate year-one general surgery and urology residents (n=14) performed a live laparoscopic porcine cholecystectomy. Trained surgeons rated their performance using OSATS and GOALS assessment scales. Results Pearson's correlation coefficient between OSATS and GOALS was 0.96 for overall scores. It ranged from 0.78 - 0.89 for domains that overlapped between the two scales. Conclusion There is a very high correlation between OSATS and GOALS. This implies that they likely measure similar constructs and that either may be used for summative-type assessments of trainee skill. However, further investigation is needed to determine if technique-specific assessments may provide more useful feedback in formative evaluation.

  11. IMPROVEMENT OF SYSTEMS OF TECHNICAL WATER SUPPLY WITH COOLING TOWERS FOR HEAT POWER PLANTS TECHNICAL AND ECONOMIC INDICATORS PERFECTION. Part 2

    Directory of Open Access Journals (Sweden)

    Yu. A. Zenovich-Leshkevich-Olpinskiy

    2016-01-01

    Full Text Available The method of calculation of economic efficiency that can be universal and is suitable for feasibility study of modernization of irrigation and water distribution system of cooling towers has been developed. The method takes into account the effect of lower pressure exhaust steam in the condenser by lowering the temperature of the cooling water outlet of a cooling tower that aims at improvement of technical and economic indicators of heat power plants. The practical results of the modernization of irrigation and water distribution system of a cooling tower are presented. As a result, the application of new irrigation and water distribution systems of cooling towers will make it possible to increase the cooling efficiency by more than 4 оС and, therefore, to obtain the fuel savings by improving the vacuum in the turbine condensers. In addition, the available capacity of CHP in the summer period is increased. The results of the work, the experience of modernization of irrigation and water distribution systems of the Gomel CHP-2 cooling towers system, as well as the and methods of calculating of its efficiency can be disseminated for upgrading similar facilities at the power plants of the Belarusian energy system. Some measures are prosed to improve recycling systems, cooling towers and their structures; such measures might significantly improve the reliability and efficiency of technical water supply systems of heat power plants.

  12. Technical specifications: Perry Nuclear Power Plant, unit no. 1 (Docket no. 50-440): Appendix ''A'' to license no. NPF-58

    International Nuclear Information System (INIS)

    1986-11-01

    This report presents technical specifications for the Perry-1 Reactor in the areas of: safety limits and limiting safety system settings; limiting conditions for operation and surveillance requirements; design features; and administrative controls

  13. Small Business Innovation Research to Support Aging Aircraft. Priority Technical Areas and Process Improvements

    National Research Council Canada - National Science Library

    2001-01-01

    .... The program is designed to stimulate technology innovation by small businesses, provide technical and scientific solutions to challenging problems, and encourage the marketing of the resulting new...

  14. Improving developer productivity with C++ embedded domain specific languages

    Science.gov (United States)

    Kozacik, Stephen; Chao, Evenie; Paolini, Aaron; Bonnett, James; Kelmelis, Eric

    2017-05-01

    Domain-specific languages are a useful tool for productivity allowing domain experts to program using familiar concepts and vocabulary while benefiting from performance choices made by computing experts. Embedding the domain specific language into an existing language allows easy interoperability with non-domain-specific code and use of standard compilers and build systems. In C++, this is enabled through the template and preprocessor features. C++ embedded domain specific languages (EDSLs) allow the user to write simple, safe, performant, domain specific code that has access to all the low-level functionality that C and C++ offer as well as the diverse set of libraries available in the C/C++ ecosystem. In this paper, we will discuss several tools available for building EDSLs in C++ and show examples of projects successfully leveraging EDSLs. Modern C++ has added many useful new features to the language which we have leveraged to further extend the capability of EDSLs. At EM Photonics, we have used EDSLs to allow developers to transparently benefit from using high performance computing (HPC) hardware. We will show ways EDSLs combine with existing technologies and EM Photonics high performance tools and libraries to produce clean, short, high performance code in ways that were not previously possible.

  15. Istra district heating system. Specific technical report. Appendix 2 to the master plan

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-09-01

    The objective of the master plan project is to improve heat supply in Istra. The considerable system losses from the fuel supplied to the end-users are one subject for improvement. At the same time, the current system operation results in poor quality heat for the consumers. Due to the inflexibility of the system, the dwellings/premises of the consumers are either overheated or insufficiently heated. The financial situation in Istra, the legal ownership of the district heating system and consumers ability to pay limit the possibilities for system improvements. The Master Plan and Feasibility Study evaluates four different development scenarios. Each of the scenarios is compared to the current situation in Istra, where nothing is done to change the system, but only to operate the present system in a sustainable way. The sustainable operation of the district heating system includes all necessary renovations and component replacements necessary. The project does not take into account the present financial situation in Istra, which has resulted in less maintenance than necessary. This situation is not a comparable parameter, as it is not sustainable and will lead to a breakdown of the heat supply within a short time horizon. (EHS)

  16. Technical Note: Evaluation of individual ultraviolet radiation dosimeter sensitivity and specificity for assessing shade use.

    Science.gov (United States)

    Holcomb, K E; Stull, C L

    2017-09-01

    The effects of solar or UV radiation on livestock are often evaluated in research focused on heat stress, dermatological conditions, and other topics, with radiation measurements recorded by instrumentation at a field or local weather station for a general geographical location. Individual sensors would be valuable for quantifying an individual animal's exposure, especially as they move about in a heterogeneous environment. Individual commercially available UV dosimeters were evaluated for specificity and sensitivity and found to be potentially valuable research tools for assessing and comparing the UV radiation exposure of individual animals.

  17. Technical-evaluation report on the proposed technical-specification changes on degraded grid-voltage protection for the Rancho Seco Nuclear Generating Plant (Docket No. 50-312)

    International Nuclear Information System (INIS)

    Selan, J.C.

    1983-01-01

    This Technical Evaluation Report is a revision and contains supplemental information to the Technical Evaluations documented in previous LLNL reports dated October 1980 (UCID-18690), November 10, 1981 (UCID-19113), and July 15, 1983 (UCID-19708). These reports encompass the NRC requirements on Degraded Grid Voltage Protection and Adequacy of Station Electric Distribution System Voltages. The evaluation finds that the proposed Technical Specification changes on the undervoltage/overvoltage trip setpoints and Limiting Conditions for Operation provide the required protection to the Class 1E Equipment from sustained abnormal voltages

  18. Improving Technical Vocational Education and Training in the Kurdistan Region--Iraq

    Science.gov (United States)

    Constant, Louay; Culbertson, Shelly; Stasz, Cathleen; Vernez, Georges

    2014-01-01

    As Iraq's Kurdistan region develops rapidly, it is creating jobs that require a solid education and technical skills. The government has launched an ambitious reform of basic and secondary education to increase its quality and has expanded opportunities for tertiary technical and university education. But expansion of secondary vocational…

  19. Improving Free-Piston Stirling Engine Specific Power

    Science.gov (United States)

    Briggs, Maxwell H.

    2015-01-01

    This work uses analytical methods to demonstrate the potential benefits of optimizing piston and/or displacer motion in a Stirling engine. Isothermal analysis was used to show the potential benefits of ideal motion in ideal Stirling engines. Nodal analysis is used to show that ideal piston and displacer waveforms are not optimal in real Stirling engines. Constrained optimization was used to identify piston and displacer waveforms that increase Stirling engine specific power.

  20. CT-guided Bipolar and Multipolar Radiofrequency Ablation (RF Ablation) of Renal Cell Carcinoma: Specific Technical Aspects and Clinical Results

    Energy Technology Data Exchange (ETDEWEB)

    Sommer, C. M., E-mail: christof.sommer@med.uni-heidelberg.de [University Hospital Heidelberg, INF 110, Department of Diagnostic and Interventional Radiology (Germany); Lemm, G.; Hohenstein, E. [Minimally Invasive Therapies and Nuclear Medicine, SLK Kliniken Heilbronn GmbH, Clinic for Radiology (Germany); Bellemann, N.; Stampfl, U. [University Hospital Heidelberg, INF 110, Department of Diagnostic and Interventional Radiology (Germany); Goezen, A. S.; Rassweiler, J. [Clinic for Urology, SLK Kliniken Heilbronn GmbH (Germany); Kauczor, H. U.; Radeleff, B. A. [University Hospital Heidelberg, INF 110, Department of Diagnostic and Interventional Radiology (Germany); Pereira, P. L. [Minimally Invasive Therapies and Nuclear Medicine, SLK Kliniken Heilbronn GmbH, Clinic for Radiology (Germany)

    2013-06-15

    Purpose. This study was designed to evaluate the clinical efficacy of CT-guided bipolar and multipolar radiofrequency ablation (RF ablation) of renal cell carcinoma (RCC) and to analyze specific technical aspects between both technologies. Methods. We included 22 consecutive patients (3 women; age 74.2 {+-} 8.6 years) after 28 CT-guided bipolar or multipolar RF ablations of 28 RCCs (diameter 2.5 {+-} 0.8 cm). Procedures were performed with a commercially available RF system (Celon AG Olympus, Berlin, Germany). Technical aspects of RF ablation procedures (ablation mode [bipolar or multipolar], number of applicators and ablation cycles, overall ablation time and deployed energy, and technical success rate) were analyzed. Clinical results (local recurrence-free survival and local tumor control rate, renal function [glomerular filtration rate (GFR)]) and complication rates were evaluated. Results. Bipolar RF ablation was performed in 12 procedures and multipolar RF ablation in 16 procedures (2 applicators in 14 procedures and 3 applicators in 2 procedures). One ablation cycle was performed in 15 procedures and two ablation cycles in 13 procedures. Overall ablation time and deployed energy were 35.0 {+-} 13.6 min and 43.7 {+-} 17.9 kJ. Technical success rate was 100 %. Major and minor complication rates were 4 and 14 %. At an imaging follow-up of 15.2 {+-} 8.8 months, local recurrence-free survival was 14.4 {+-} 8.8 months and local tumor control rate was 93 %. GFR did not deteriorate after RF ablation (50.8 {+-} 16.6 ml/min/1.73 m{sup 2} before RF ablation vs. 47.2 {+-} 11.9 ml/min/1.73 m{sup 2} after RF ablation; not significant). Conclusions. CT-guided bipolar and multipolar RF ablation of RCC has a high rate of clinical success and low complication rates. At short-term follow-up, clinical efficacy is high without deterioration of the renal function.

  1. RAMS+C informed decision-making with application to multi-objective optimization of technical specifications and maintenance using genetic algorithms

    International Nuclear Information System (INIS)

    Martorell, S.; Villanueva, J.F.; Carlos, S.; Nebot, Y.; Sanchez, A.; Pitarch, J.L.; Serradell, V.

    2005-01-01

    The role of technical specifications and maintenance (TSM) activities at nuclear power plants (NPP) aims to increase reliability, availability and maintainability (RAM) of Safety-Related Equipment, which, in turn, must yield to an improved level of plant safety. However, more resources (e.g. costs, task force, etc.) have to be assigned in above areas to achieve better scores in reliability, availability, maintainability and safety (RAMS). Current situation at NPP shows different programs implemented at the plant that aim to the improvement of particular TSM-related parameters where the decision-making process is based on the assessment of the impact of the change proposed on a subgroup of RAMS+C attributes. This paper briefly reviews the role of TSM and two main groups of improvement programs at NPP, which suggest the convenience of considering the approach proposed in this paper for the Integrated Multi-Criteria Decision-Making on changes to TSM-related parameters based on RAMS+C criteria as a whole, as it can be seem as a decision-making process more consistent with the role and synergic effects of TSM and the objectives and goals of current improvement programs at NPP. The case of application to the Emergency Diesel Generator system demonstrates the viability and significance of the proposed approach for the Multi-objective Optimization of TSM-related parameters using a Genetic Algorithm

  2. Implantable cardioverter defibrillator specific rehabilitation improves health cost outcomes

    DEFF Research Database (Denmark)

    Kikkenborg Berg, Selina; Zwisler, Ann-Dorthe; Koch, Mette Bjerrum

    2015-01-01

    of the rehabilitation group for exercise capacity, general and mental health. The aim of this paper is to explore the long-term health effects and cost implications associated with the rehabilitation programme; more specifically, (i) to compare implantable cardioverter defibrillator therapy history and mortality...... was -6,789 USD/-5,593 Euro in favour of rehabilitation. Conclusion: No long-term health outcome benefits were found for the rehabilitation programme. However, the rehabilitation programme resulted in a reduction in total attributable direct costs....

  3. A technical basis to relax the dew point specification for the environment in the vapor space in DWPF canisters

    International Nuclear Information System (INIS)

    Louthan, M.R. Jr.

    1995-05-01

    This memorandum establishes the technical basis to conclude that relaxing, from 0 C to 20 C, the dew point specification for the atmosphere in the vapor space (free volume) of a DWPF canister will not provide an environment that will cause significant amounts of corrosion induced degradation of the canister wall. The conclusion is based on engineering analysis, experience and review of the corrosion literature. The basic assumptions underlying the conclusion are: (1) the canister was fabricated from Type 304L stainless steel; (2) the corrosion behavior of the canister material, including base metal, fusion zones and heat effected zones, is typified by literature data for, and industrial experience with, 300 series austenitic stainless steels; and (3) the glass-metal crevices created during the pouring operation will not alter the basic corrosion resistance of the steel although such crevices might serve as sites for the initiation of minor amounts of corrosion on the canister wall

  4. New Unesco Project To Improve Primary School Performance through Improved Nutrition and Health. First Technical Report. Nutrition Education Series, Issue 18.

    Science.gov (United States)

    United Nations Educational, Scientific, and Cultural Organization, Paris (France). Div. of Science, Technical and Environmental Education.

    A new Unesco project seeks to increase the capacity of developing countries to strengthen primary school academic performance by improving children's nutrition and health status. The first technical meeting of the new project took place in Stockholm, Sweden, in April 1989. Three working groups were formed which focused on assessment, intervention,…

  5. Validation of detailed thermal hydraulic models used for LMR safety and for improvement of technical specifications

    Energy Technology Data Exchange (ETDEWEB)

    Dunn, F.E.

    1995-12-31

    Detailed steady-state and transient coolant temperatures and flow rates from an operating reactor have been used to validate the multiple pin model in the SASSYS-1 liquid metal reactor systems analysis code. This multiple pin capability can be used for explicit calculations of axial and lateral temperature distributions within individual subassemblies. Thermocouples at a number of axial locations and in a number of different coolant sub-channels m the XXO9 instrumented subassembly in the EBR-II reactor provided temperature data from the Shutdown Heat Removal Test (SHRT) series. Flow meter data for XXO9 and for the overall system are also available from these tests. Results of consistent SASSYS-1 multiple pin analyses for both the SHRT-45 loss-of-flow-without-scram-test and the S14RT-17 protected loss-of-flow test agree well with the experimental data, providing validation of the SASSYS-1 code over a wide range of conditions.

  6. Risk-based configuration control: Application of PRA in improving technical specifications and operational safety

    Energy Technology Data Exchange (ETDEWEB)

    Samanta, P.K.; Kim, I.S. (Brookhaven National Lab., Upton, NY (United States)); Vesely, W.E. (Science Applications International Corp., Columbus, OH (United States))

    1991-01-01

    The objective of risk-based configuration control is to detect and control plant configurations form a risk perspective. The configurations of particular interest involve components which are down during power operation. Controlling plant configurations from a risk-perspective can provide more direct risk control and also more operational flexibility by allowing looser control in areas unimportant to risk.

  7. Risk-based configuration control: Application of PRA in improving technical specifications and operational safety

    Energy Technology Data Exchange (ETDEWEB)

    Samanta, P.K.; Kim, I.S. [Brookhaven National Lab., Upton, NY (United States); Vesely, W.E. [Science Applications International Corp., Columbus, OH (United States)

    1991-12-31

    The objective of risk-based configuration control is to detect and control plant configurations form a risk perspective. The configurations of particular interest involve components which are down during power operation. Controlling plant configurations from a risk-perspective can provide more direct risk control and also more operational flexibility by allowing looser control in areas unimportant to risk.

  8. Developing and Improving Student Non-Technical Skills in IT Education: A Literature Review and Model

    Directory of Open Access Journals (Sweden)

    Marcia Hagen

    2016-06-01

    Full Text Available The purpose of this paper is to identify portions of the literature in the areas of Information Technology (IT management, skills development, and curriculum development that support the design of a holistic conceptual framework for instruction in non-technical skills within the IT higher education context. This article review provides a framework for understanding how the critical success factors related to IT and Information Systems (IS professional success is impacted by developing students’ non-technical skills. The article culminates in a holistic conceptual framework for developing non-technical skills within the IT higher education context. Implications for theory and research are provided.

  9. Prototype design for a predictive model to improve evacuation operations : technical report.

    Science.gov (United States)

    2011-08-01

    Mass evacuations of the Texas Gulf Coast remain a difficult challenge. These events are massive in scale, : highly complex, and entail an intricate, ever-changing conglomeration of technical and jurisdictional issues. : This project focused primarily...

  10. Technical note: Improving modeling of coagulation, curd firming, and syneresis of sheep milk.

    Science.gov (United States)

    Cipolat-Gotet, Claudio; Pazzola, Michele; Ferragina, Alessandro; Cecchinato, Alessio; Dettori, Maria L; Vacca, Giuseppe M

    2018-04-18

    The importance of milk coagulation properties for milk processing, cheese yield, and quality is widely recognized. The use of traditional coagulation traits presents several limitations for testing bovine milk and even more for sheep milk, due to its rapid coagulation and curd firming, and early syneresis of coagulum. The aim of this technical note is to test and improve model fitting for assessing coagulation, curd firming, and syneresis of sheep milk. Using milk samples from 87 Sarda ewes, we performed in duplicate lactodynamographic testing. On each of the 174 analyzed milk aliquots, using 180 observations from each aliquot (one every 15 s for 45 min after rennet addition), we compared 4 different curd firming models as a function of time (CF t , mm) using a nonlinear procedure. The most accurate and informative results were observed using a modified 4-parameter model, structured as follows: [Formula: see text] , where t is time, RCT eq (min) is the gelation time, CF P (mm) is the potential asymptotical CF at an infinite time, k CF (%/min) is the curd firming rate constant, and k SR (%/min) is the curd syneresis rate constant. To avoid nonconvergence and computational problems due to interrelations among the equation parameters, CF P was preliminarily defined as a function of maximum observed curd firmness (CF max , mm) recorded during the analysis. For this model, all the modeling equations of individual sheep milk aliquots were converging, with a negligible standard error of the estimates (coefficient of determination >0.99 for all individual sample equations). Repeatability of the modeled parameters was acceptable, also in the presence of curd syneresis during the lactodynamographic analysis. Copyright © 2018 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  11. Correction of technical bias in clinical microarray data improves concordance with known biological information

    DEFF Research Database (Denmark)

    Eklund, Aron Charles; Szallasi, Zoltan Imre

    2008-01-01

    The performance of gene expression microarrays has been well characterized using controlled reference samples, but the performance on clinical samples remains less clear. We identified sources of technical bias affecting many genes in concert, thus causing spurious correlations in clinical data...... sets and false associations between genes and clinical variables. We developed a method to correct for technical bias in clinical microarray data, which increased concordance with known biological relationships in multiple data sets....

  12. EUROSAFE Forum for nuclear safety. Towards Convergence of Technical Nuclear Safety Practices in Europe. Safety Improvements - Reasons, Strategies, Implementation

    International Nuclear Information System (INIS)

    Erven, Ulrich; Cherie, Jean-Bernard; Boeck, Benoit De

    2005-01-01

    The EUROSAFE Forum for Nuclear Safety is part of the EUROSAFE approach, which consists of two further elements: the EUROSAFE Tribune and the EUROSAFE Web site. The general aim of EUROSAFE is to contribute to fostering the convergence of technical nuclear safety practices in a broad European context. This is done by providing technical safety and research organisations, safety authorities, power utilities, the rest of the industry and non-governmental organisations mainly from the European Union and East-European countries, and international organisations with a platform for the presentation of recent analyses and R and D in the field of nuclear safety. The goal is to share experiences, to exchange technical and scientific opinions, and to conduct debates on key issues in the fields of nuclear safety and radiation protection. The EUROSAFE Forum on 2005 focused on Safety Improvements, Reasons - Strategies - Implementation, from the point of view of the authorities, TSOs and industry. Latest work in nuclear installation safety and research, waste management, radiation safety as well as nuclear material and nuclear facilities security carried out by GRS, IRSN, AVN and their partners in the European Union, Switzerland and Eastern Europe are presented. A high level of nuclear safety is a priority for the countries of Europe. The technical safety organisations play an important role in contributing to that objective through appropriate approaches to major safety issues as part of their assessments and research activities. The challenges to nuclear safety are international. Changes in underlying technologies such as instrumentation and control, the impact of electricity market deregulation, demands for improved safety and safety management, the ageing of nuclear facilities, waste management, maintaining and improving scientific and technical knowledge, and the need for greater transparency - these are all issues where the value of an international approach is gaining

  13. EUROSAFE Forum for nuclear safety. Towards Convergence of Technical Nuclear Safety Practices in Europe. Safety Improvements - Reasons, Strategies, Implementation

    Energy Technology Data Exchange (ETDEWEB)

    Erven, Ulrich (ed.) [Gesellschaft fuer Anlagen- und Reaktorsicherheit, GRS mbH, Schwertnergasse 1, 50667 Koeln (Germany); Cherie, Jean-Bernard (ed.) [Institut de Radioprotection et de Surete Nucleaire, IRSN, BP 17, 92262 Fontenay-aux-Roses Cedex (France); Boeck, Benoit De (ed.) [Association Vincotte Nuclear, AVN, Rue Walcourt 148, 1070 Bruxelles (Belgium)

    2005-07-01

    The EUROSAFE Forum for Nuclear Safety is part of the EUROSAFE approach, which consists of two further elements: the EUROSAFE Tribune and the EUROSAFE Web site. The general aim of EUROSAFE is to contribute to fostering the convergence of technical nuclear safety practices in a broad European context. This is done by providing technical safety and research organisations, safety authorities, power utilities, the rest of the industry and non-governmental organisations mainly from the European Union and East-European countries, and international organisations with a platform for the presentation of recent analyses and R and D in the field of nuclear safety. The goal is to share experiences, to exchange technical and scientific opinions, and to conduct debates on key issues in the fields of nuclear safety and radiation protection. The EUROSAFE Forum on 2005 focused on Safety Improvements, Reasons - Strategies - Implementation, from the point of view of the authorities, TSOs and industry. Latest work in nuclear installation safety and research, waste management, radiation safety as well as nuclear material and nuclear facilities security carried out by GRS, IRSN, AVN and their partners in the European Union, Switzerland and Eastern Europe are presented. A high level of nuclear safety is a priority for the countries of Europe. The technical safety organisations play an important role in contributing to that objective through appropriate approaches to major safety issues as part of their assessments and research activities. The challenges to nuclear safety are international. Changes in underlying technologies such as instrumentation and control, the impact of electricity market deregulation, demands for improved safety and safety management, the ageing of nuclear facilities, waste management, maintaining and improving scientific and technical knowledge, and the need for greater transparency - these are all issues where the value of an international approach is gaining

  14. TECHNICAL AND ENERGY PARAMETERS IMPROVEMENT OF DIESEL LOCOMOTIVES THROUGH THE INTRODUCTION OF AUTOMATED CONTROL SYSTEMS OF A DIESEL

    Directory of Open Access Journals (Sweden)

    M. I. Kapitsa

    2015-04-01

    Full Text Available Purpose. Today the issue, connected with diesel traction remains relevant for the majority of industrial enterprises and Ukrainian railways and diesel engine continues to be the subject of extensive research and improvements. Despite the intensive process of electrification, which accompanies Railway Transport of Ukraine the last few years, diesel traction continues to play an important role both in the main and in the industrial railway traction rolling stock. Anyway, all kinds of maneuvering and chores are for locomotives, they are improved and upgraded relentlessly and hourly. This paper is focused on finding the opportunities to improve technical and energy parameters of diesels due to the development of modern control method of the fuel equipment in the diesel engine. Methodology. The proposed method increases the power of locomotives diesel engines in the range of crankshaft rotation (from idle running to maximum one. It was based on approach of mixture ignition timing up to the top «dead» center of piston position. Findings. The paper provides a brief historical background of research in the area of operating cycle in the internal combustion engine (ICE. The factors affecting the process of mixing and its quality were analyzed. The requirements for fuel feed system in to the cylinder and the «weak points» of the process were presented. A variant of the modification the fuel pump drive, which allows approaching to the regulation of fuel feed system from the other hand and to improve it was proposed. Represents a variant of embodiment of the complex system with specification of mechanical features and control circuits. The algorithm of the system operation was presented and its impact on the performance of diesel was made. Originality. The angle regulating system of fuel supply allows automating the process of fuel injection advance angle into the cylinder. Practical value. At implementation the angle regulating system of fuel supply

  15. A technical system to improve the operational monitoring of the Zaporozh'ye nuclear power plant

    International Nuclear Information System (INIS)

    Beyer, M.; Carl, H.; Schumann, P.; Seidel, A.; Weiss, F.-P.; Zschau, J.; Nowak, K.

    1997-01-01

    As part of a programme of cooperation with Central and Eastern European states, a technical system has been established for the Zaporozhe nuclear power plant, which complements existing operational checking and monitoring facilities with modern means of information technology. It makes it possible to continuously monitor the state of the units in normal operation and in cases of anomalies or incidents. The parameters selected for monitoring are listed, and the system of automatic evaluation at the power plant site is described in detail. Test operation of the technical system started in late 1995 and the industrial testing phase in mid-1996. (A.K.)

  16. Customer's self-audit to improve the technical quality of maternity care in Tabriz: a community trial.

    Science.gov (United States)

    Gholipour, K; Tabrizi, J S; Asghari-Jafarabadi, M; Iezadi, S; Farshbaf, N; Rahbar-Farzam, F; Afsharniya, F

    2016-08-18

    Pregnant women have a major role to play in assessing and improving their own quality of care. This study in Tabriz, Islamic Republic of Iran, aimed to assess the effectiveness of an intervention for pregnant women-based on education and support groups and involvement in quality assessment activities-in order to improve the technical quality of public maternity care at public health centres. The intervention phase began in September 2011 and lasted 8 months. The outcome measure was health-care providers' degree of adherence to the Iranian maternity care standards. An intervention group of 92 pregnant women from 10 health centres was compared with a control group of 93 pregnant women from 11 centres. Logistic regression analysis showed that the self-assessed technical quality of maternity care received by the women was significantly better in the intervention that the control group for several of the standards concerning clinical examinations, maternal education and vitamin and mineral supplements.

  17. Meta-Analysis as a Choice to Improve Research in Career and Technical Education

    Science.gov (United States)

    Gordon, Howard R. D.; McClain, Clifford R.; Kim, Yeonsoo; Maldonado, Cecilia

    2010-01-01

    A search of the ERIC and Academic Search Premier data bases, and a comprehensive review of literature suggest that meta-analysis is ignored by career and technical education (CTE) researchers, a situation that is regrettable but remediable. The purpose of this theoretical paper is to provide CTE researchers and consumers with procedures for…

  18. 76 FR 48822 - Applications for New Awards; Technical Assistance and Dissemination To Improve Services and...

    Science.gov (United States)

    2011-08-09

    ..., Park, Santamaria, van der Mandele, Keene, Taylor, 2010; Stone, Alfeld, Pearson, Lewis, Jensen, 2006... technical assistance. Scaling Up Brief #2. Chapel Hill: The University of North Carolina, FPG, SISEP. Fixsen... synthesis of the literature. Tampa, FL: University of South Florida, Louis de la Parte Florida Mental Health...

  19. 76 FR 50189 - Applications for New Awards; Technical Assistance and Dissemination To Improve Services and...

    Science.gov (United States)

    2011-08-12

    ..., Department of Education. ACTION: Notice. Overview Information Technical Assistance and Dissemination to... fewer than 10,000 children from families with incomes below the poverty line (as that term is defined in... from families with incomes below the poverty line; and (b) For which there is (1) a high percentage of...

  20. Implicit Treatment of Technical Specification and Thermal Hydraulic Parameter Uncertainties in Gaussian Process Model to Estimate Safety Margin

    Directory of Open Access Journals (Sweden)

    Douglas A. Fynan

    2016-06-01

    Full Text Available The Gaussian process model (GPM is a flexible surrogate model that can be used for nonparametric regression for multivariate problems. A unique feature of the GPM is that a prediction variance is automatically provided with the regression function. In this paper, we estimate the safety margin of a nuclear power plant by performing regression on the output of best-estimate simulations of a large-break loss-of-coolant accident with sampling of safety system configuration, sequence timing, technical specifications, and thermal hydraulic parameter uncertainties. The key aspect of our approach is that the GPM regression is only performed on the dominant input variables, the safety injection flow rate and the delay time for AC powered pumps to start representing sequence timing uncertainty, providing a predictive model for the peak clad temperature during a reflood phase. Other uncertainties are interpreted as contributors to the measurement noise of the code output and are implicitly treated in the GPM in the noise variance term, providing local uncertainty bounds for the peak clad temperature. We discuss the applicability of the foregoing method to reduce the use of conservative assumptions in best estimate plus uncertainty (BEPU and Level 1 probabilistic safety assessment (PSA success criteria definitions while dealing with a large number of uncertainties.

  1. Improved Management of the Technical Interfaces Between the Hanford Tank Farm Operator and the Hanford Waste Treatment Plant - 13383

    Energy Technology Data Exchange (ETDEWEB)

    Duncan, Garth M. [Bechtel National Inc., 2435 Stevens Center Place, Richland, Washington, 99352 (United States); Saunders, Scott A. [Washington River Protection Solutions, P.O. Box 850, Richland, Washington, 99352 (United States)

    2013-07-01

    2010-2; - Development of a set of alternatives to the current baseline that involve aspects of direct feed, feed conditioning, and design changes. The One System Technical Organization has served WTP, TOC, and DOE well in managing and resolving issues at the interface. This paper describes the organizational structure used to improve the interface and several examples of technical interface issues that have been successfully addressed by the new organization. (authors)

  2. Improved Management of the Technical Interfaces Between the Hanford Tank Farm Operator and the Hanford Waste Treatment Plant - 13383

    International Nuclear Information System (INIS)

    Duncan, Garth M.; Saunders, Scott A.

    2013-01-01

    2010-2; - Development of a set of alternatives to the current baseline that involve aspects of direct feed, feed conditioning, and design changes. The One System Technical Organization has served WTP, TOC, and DOE well in managing and resolving issues at the interface. This paper describes the organizational structure used to improve the interface and several examples of technical interface issues that have been successfully addressed by the new organization. (authors)

  3. Site-Specific Modification Using the 2′-Methoxyethyl Group Improves the Specificity and Activity of siRNAs

    Directory of Open Access Journals (Sweden)

    Xinyun Song

    2017-12-01

    Full Text Available Rapid progress has been made toward small interfering RNA (siRNA-based therapy for human disorders, but rationally optimizing siRNAs for high specificity and potent silencing remains a challenge. In this study, we explored the effect of chemical modification at the cleavage site of siRNAs. We found that modifications at positions 9 and 10 markedly reduced the silencing potency of the unmodified strand of siRNAs but were well tolerated by the modified strand. Intriguingly, addition of the 2′-methoxyethyl (MOE group at the cleavage site improved both the specificity and silencing activity of siRNAs by facilitating the oriented RNA-induced silencing complex (RISC loading of the modified strand. Furthermore, we combined MOE modifications at positions 9 and 10 of one strand together with 2′-O-methylation (OMe at position 14 of the other strand and found a synergistic effect that improved the specificity of siRNAs. The surprisingly beneficial effect of the combined modification was validated using siRNA-targeting endogenous gene intercellular adhesion molecule 1 (ICAM1. We found that the combined modifications eliminated its off-target effects. In conclusion, we established effective strategies to optimize siRNAs using site-specific MOE modifications. The findings may allow the creation of superior siRNAs for therapy in terms of activity and specificity.

  4. Site-Specific Modification Using the 2'-Methoxyethyl Group Improves the Specificity and Activity of siRNAs.

    Science.gov (United States)

    Song, Xinyun; Wang, Xiaoxia; Ma, Yuan; Liang, Zicai; Yang, Zhenjun; Cao, Huiqing

    2017-12-15

    Rapid progress has been made toward small interfering RNA (siRNA)-based therapy for human disorders, but rationally optimizing siRNAs for high specificity and potent silencing remains a challenge. In this study, we explored the effect of chemical modification at the cleavage site of siRNAs. We found that modifications at positions 9 and 10 markedly reduced the silencing potency of the unmodified strand of siRNAs but were well tolerated by the modified strand. Intriguingly, addition of the 2'-methoxyethyl (MOE) group at the cleavage site improved both the specificity and silencing activity of siRNAs by facilitating the oriented RNA-induced silencing complex (RISC) loading of the modified strand. Furthermore, we combined MOE modifications at positions 9 and 10 of one strand together with 2'-O-methylation (OMe) at position 14 of the other strand and found a synergistic effect that improved the specificity of siRNAs. The surprisingly beneficial effect of the combined modification was validated using siRNA-targeting endogenous gene intercellular adhesion molecule 1 (ICAM1). We found that the combined modifications eliminated its off-target effects. In conclusion, we established effective strategies to optimize siRNAs using site-specific MOE modifications. The findings may allow the creation of superior siRNAs for therapy in terms of activity and specificity. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  5. Technical specifications: Susquehanna Steam Electric Station, Unit No. 2 (Docket No. 50-388). Appendix A to License No. NPF-22

    International Nuclear Information System (INIS)

    1984-03-01

    Susquehanna Steam Electric Station, Unit 2 Technical Specifications were prepared by the US Nuclear Regulatory Commission to set forth the limits, operating conditions, and other requirements applicable to a nuclear reactor facility as set forth in Section 50.36 of 10 CFR Part 50 for the protection of the health and safety of the public

  6. Technical specifications, Braidwood Station, Unit Nos. 1 and 2 (Docket Nos. STN 50-456 and STN 50-457): Appendix ''A'' to License No. NPF-70

    International Nuclear Information System (INIS)

    1987-05-01

    The Braidwood Station, Unit Nos. 1 and 2, Technical Specifications were prepared by the US Nuclear Regulatory Commission to set forth the limits, operating conditions, and other requirements applicable to a nuclear reactor facility as set forth in Section 50.36 of 10 CFR Part 50 for the protection of the health and safety of the public. 18 figs., 55 tabs

  7. Technical specifications, Palo Verde Nuclear Generating Station, Unit No. 1 (Docket No. 50-528). Appendix A to License No. NPF-34

    International Nuclear Information System (INIS)

    1984-12-01

    Technical specifications are presented concerning operating safety limits for reactivity control systems, power distribution, instrumentation, coolant system, emergency core cooling system, containment systems, plant systems, electrical power systems, refueling operations, radioactive effluents, and radiological environmental monitoring; design features of the reactor site, containment, reactor core, coolant system, and fuel storage; and administrative controls

  8. Resolution 127/012. It approve the fuel quality 50-S Oil Gas characteristics within the framework of Technical Quality Specifications Rules for liquid fuel

    International Nuclear Information System (INIS)

    2012-01-01

    This resolution approves the initiative of Ancap fuel quality 50-S Oil Gas characteristics within the framework of Technical Quality Specifications Rules for liquid fuel. This resolution is according to the opinion of the National Energy Regulatory Unit and the Energy and Water Services in relation with the requirements of the current rule.

  9. Technical specifications, Waterford Steam Electric Station, Unit No. 3 (Docket No. 50-382). Appendix A to License No. NPF-38

    International Nuclear Information System (INIS)

    1985-03-01

    The Waterford, Unit 3 Technical Specifications were prepared by the US Nuclear Regulatory Commission to set forth the limits, operating conditions, and other requirements applicable to a nuclear reactor facility as set forth in Section 50.36 of 10 CFR Part 50 for the protection of the health and safety of the public

  10. Heat transfer calculations for the High Flux Isotope Reactor (HFIR). Technical specifications: bases for safety limits and limiting safety system settings

    International Nuclear Information System (INIS)

    Sims, T.M.; Swanks, J.H.

    1977-09-01

    Heat transfer analyses, in support of the preparation of the HFIR technical specifications, were made to establish the bases for the safety limits and limiting safety system settings applicable to the HFIR. The results of these analyses, along with the detailed bases, are presented

  11. Technical specifications, Shoreham Nuclear Power Station, Unit No. 1 (Docket No. 50-322): Appendix ''A'' to License No. NPF-82

    International Nuclear Information System (INIS)

    1989-04-01

    The Shoreham, Unit 1, Technical Specifications were prepared by the US Nuclear Regulatory Commission to set forth the limits, operating conditions, and other requirements applicable to a nuclear facility as set forth in Section 50.36 of 10 CFR Part 50 for the protection of the health and safety of the public. 20 figs., 75 tabs

  12. Moving Towards a Technical Specification for Fluorescence Excitation-Emission Mapping and Absorbance Analysis of Colored Dissolved Organic Matter

    Science.gov (United States)

    Gilmore, A. M.

    2010-12-01

    Colored dissolved organic matter (CDOM) measurements with fluorescence and absorbance are important for evaluating a wide variety natural and industrial water sources. However, uncertainties and ambiguities continue to be propagated regarding interpretation of CDOM spectral data due to the variety of instruments, sampling chemistry conditions and types of analysis algorithms. Recent efforts have focused on standardization and interlaboratory comparisons of CDOM samples with respect to preparation, spectroscopic evaluation and mathematical analysis. This study deals with correlating absorbance and fluorescence data measured with the same sample to minimize interlaboratory variation. The theoretical significance of true simultaneous acquisition of the corrected (NIST Traceable) absorbance spectrum and fluorescence excitation spectral profile and excitation emission map is discussed as a means to provide the least ambiguous spectral data. Key issues considered are the variations introduced by ‘serial’ acquisitions of absorbance and fluorescence data. Variation can be caused by the different light-exposure history (especially UV) in the instruments, dissolved oxygen content associated with temperature changes and oxidation kinetics of the CDOM and in many cases concentration- and pH-related changes associated with diluting and pH buffering of the CDOM sample, respectively. Concentration changes in CDOM can be associated with optical anomalies including self-quenching and -absorption which systematically alter the fluorescence spectrum. Clearly, monitoring the absorbance and fluorescence simultaneously would deal with the above sampling variations and facilitate correcting the absorbance based fluorescence anomalies. The proposed method(s) described will be discussed in view of their potential to serve as the basis for an international technical specification in terms of the optical instrument and sampling conditions for CDOM analysis and reporting.

  13. Critical evaluation of the nonradiological environmental technical specifications. Volume 2. Surry Power Plants, Units 1 and 2

    International Nuclear Information System (INIS)

    Adams, S.M.; Cunningham, P.A.; Gray, D.D.; Kumar, K.D.

    1976-01-01

    A comprehensive study of the data collected as part of the environmental Technical Specifications program for Units 1 and 2 of the Surry Nuclear Power Plant was carried out for the Office of Regulatory Research of the U.S. Nuclear Regulatory Commission. The program included an analysis of the hydrothermal and ecological monitoring data collected from 1973 through 1975. The hydrothermal analysis includes a discussion of models used in plume predictions prior to plant operation and an evaluation of the present hydrothermal monitoring program. The two primary methods used for temperature monitoring employ a fixed thermographs network and boat measurements. Review of data indicates that both the application and formulation of the hydrothermal monitoring program are inadequate to fully characterize the operation of the plant and the behavior of the thermal plume. Furthermore, there are no existing data that can be used to adequately verify or disprove the validity of the various Surry plume predictions. The ecological analysis includes validation of impacts predicted in the Final Environmental Statement using the operational monitoring data. Phytoplankton cell concentrations, chlorophyll a, and carbon-14 measurements were used to monitor changes in the primary producers. Densities of consumers (i.e., zooplankton, benthos, and fish) were sed to monitor changes in the primary producers. Models based on operating data were constructed to determine whether changes were occurring at each trophic level. Analysis of the monitoring data suggests that the thermal discharges at Surry are having a negative effect on the phytoplankton and zooplankton but are enhancing the benthic and nekton populations in the discharge area

  14. Critical evaluation of the nonradiological environmental technical specifications. Volume 2. Surry Power Plants, Units 1 and 2

    Energy Technology Data Exchange (ETDEWEB)

    Adams, S.M.; Cunningham, P.A.; Gray, D.D.; Kumar, K.D.

    1976-08-10

    A comprehensive study of the data collected as part of the environmental Technical Specifications program for Units 1 and 2 of the Surry Nuclear Power Plant was carried out for the Office of Regulatory Research of the U.S. Nuclear Regulatory Commission. The program included an analysis of the hydrothermal and ecological monitoring data collected from 1973 through 1975. The hydrothermal analysis includes a discussion of models used in plume predictions prior to plant operation and an evaluation of the present hydrothermal monitoring program. The two primary methods used for temperature monitoring employ a fixed thermographs network and boat measurements. Review of data indicates that both the application and formulation of the hydrothermal monitoring program are inadequate to fully characterize the operation of the plant and the behavior of the thermal plume. Furthermore, there are no existing data that can be used to adequately verify or disprove the validity of the various Surry plume predictions. The ecological analysis includes validation of impacts predicted in the Final Environmental Statement using the operational monitoring data. Phytoplankton cell concentrations, chlorophyll a, and carbon-14 measurements were used to monitor changes in the primary producers. Densities of consumers (i.e., zooplankton, benthos, and fish) were sed to monitor changes in the primary producers. Models based on operating data were constructed to determine whether changes were occurring at each trophic level. Analysis of the monitoring data suggests that the thermal discharges at Surry are having a negative effect on the phytoplankton and zooplankton but are enhancing the benthic and nekton populations in the discharge area.

  15. Airborne Laser Remote Sensor for Oil Detection and Classification : Engineering Requirements and Technical Considerations Relevant to a Performance Specification

    Science.gov (United States)

    1975-08-01

    This report outlines the engineering requirements for an Airborne Laser Remote Sensor for Oil Detection and Classification System. Detailed engineering requirements are given for the major units of the system. Technical considerations pertinent to a ...

  16. [Training design and improvement of technical skills in the transvaginal cholecystectomy (NOTES)].

    Science.gov (United States)

    Sánchez-Margallo, Francisco Miguel; Asencio Pascual, José Manuel; Del Carmen Tejonero Alvarez, María; Sánchez Hurtado, Miguel Angel; Pérez Duarte, Francisco Julián; Usón Gargallo, Jesús; Sánchez-Gijón, Salvador Pascual

    2009-05-01

    The current surgical scenario of the surgery through natural orifices or requires acquiring new technical skills by the surgeon. We introduce the initial experience of the Minimally Invasive Surgery Centre Jesús Usón (MISCJU) in the design and setting-up of a surgical training programme using the the natural orifices approach for the acquisition of surgical skills and abilities, based on the preliminary trials in simulators and a pig model. After initial training, using a laparoscopic pelvic-trainer, 7 female pigs, with weights between 35-40 kg, were operated on. The transvaginal approach was completed using a one-channel gastroscope in all the animals. After accessing the abdomen, the abdominal cavity was explored, and the surgery was concluded with the endoscopic cholecystectomy. Endoscopic cholecystectomy was successfully completed in 6 cases. In one of the animals, the procedure was stopped because of technical problems regarding the endoscope leaning to one end. The average surgical time was 107.14 min (range, 80-150 min). The transvaginal approach enabled the abdominal to be explored and the dissection, ligature and section of the cystic duct and the cystic artery. After cholecystectomy, the gallbladder was extracted through the vagina. After the procedure necropsy did not reveal intra-abdominal lesions or intraoperative complications. The pure transvaginal cholecystectomy is a feasible and reproducible procedure in the animal model. A systematized training model, which includes physiopathology knowledge as well as technical knowledge, in order to translate these procedures to the clinical practice in a safe way, is needed.

  17. Improving the quality of learning discipline “Technical thermodynamics and heat exchange” at ONMU

    Science.gov (United States)

    Vasserman, A. A.; Malchevsky, V. P.

    2017-11-01

    Discipline «Technical thermodynamics and heat exchange» creates a theoretical basis for students of ship-engineering faculty of Odessa National Maritime University to learn special subjects such as: Internal Combustion Engines, Steam and Gas Turbines, Steam Boilers, Refrigerating Plants. This course forms future specialist and provides the deep understanding of essence of thermodynamic processes which run in machines and apparatus of ship. Also different kinds of heat exchange in solid, liquid and gaseous bodies which take place almost in all technological processes are considered. The quality of training ship engineers depends on the knowledge of mentioned discipline.

  18. Technical stops: what were the issues in 2011, minimizing impact and improving recovery

    CERN Document Server

    Solfaroli Camillocci, M

    2012-01-01

    As any other accelerator, the LHC has to undertake periods of stop for maintenance. Five technical stops have been performed during the 2011 run and sometimes a quite long recovery time was experienced. An analysis of the reasons is presented paying particular attention to the interventions carried out during the stop. Following this analysis, an outlook on the future that aims to increase the LHC availability and to diminish the downtime is also considered. Further consideration is put on the possibility to perform maintenance only once the machine undergoes a problem, instead of during planned stops.

  19. IMPROVEMENT OF SYSTEMS OF TECHNICAL WATER SUPPLY WITH COOLING TOWERS FOR STEAM POWER PLANTS TECHNICAL AND ECONOMIC INDICATORS PERFECTION. Part 1

    Directory of Open Access Journals (Sweden)

    Yu. A. Zenovich-Leshkevich-Olpinskiy

    2016-01-01

    Full Text Available In order to reduce the temperature of cooling water and increase the efficiency of use of power resources the main directions of modernization of systems of technical water supply with cooling towers at steam power plants are presented. The problems of operation of irrigation systems and water distribution systems of cooling towers are reviewed. The design of heat and mass transfer devices, their shortcomings and the impact on the cooling ability of the cooling tower are also under analysis. The use of droplet heat and mass transfer device based on the lattice polypropylene virtually eliminates the shortcomings of the film and droplet-film heat and mass transfer devices of the cooling tower, increasing lifetime, and improving the reliability and efficiency of the operation of the main equipment of thermal power plants. The design of the water distribution devices of cooling towers is also considered. It is noted that the most effective are water-spattering low-pressure nozzles made of polypropylene that provides uniform dispersion of water and are of a high reliability and durability.

  20. A socio-technical approach to improving retail energy efficiency behaviours.

    Science.gov (United States)

    Christina, Sian; Waterson, Patrick; Dainty, Andrew; Daniels, Kevin

    2015-03-01

    In recent years, the UK retail sector has made a significant contribution to societal responses on carbon reduction. We provide a novel and timely examination of environmental sustainability from a systems perspective, exploring how energy-related technologies and strategies are incorporated into organisational life. We use a longitudinal case study approach, looking at behavioural energy efficiency from within one of the UK's leading retailers. Our data covers a two-year period, with qualitative data from a total of 131 participants gathered using phased interviews and focus groups. We introduce an adapted socio-technical framework approach in order to describe an existing organisational behavioural strategy to support retail energy efficiency. Our findings point to crucial socio-technical and goal-setting factors which both impede and/or enable energy efficient behaviours, these include: tensions linked to store level perception of energy management goals; an emphasis on the importance of technology for underpinning change processes; and, the need for feedback and incentives to support the completion of energy-related tasks. We also describe the evolution of a practical operational intervention designed to address issues raised in our findings. Our study provides fresh insights into how sustainable workplace behaviours can be achieved and sustained over time. Secondly, we discuss in detail a set of issues arising from goal conflict in the workplace; these include the development of a practical energy management strategy to facilitate secondary organisational goals through job redesign. Copyright © 2014 Elsevier Ltd and The Ergonomics Society. All rights reserved.

  1. 76 FR 28022 - Increasing Market and Planning Efficiency Through Improved Software; Notice of Technical...

    Science.gov (United States)

    2011-05-13

    ... Energy Regulatory Commission Increasing Market and Planning Efficiency Through Improved Software; Notice...- ] market utilities, the software industry, government, research centers and academia for the purposes of... focus on improving performance of day-ahead markets, including general unit-commitment software and...

  2. The improvement of technical skill at the stage of the specialized basic preparation in fitness by means of powerlifting

    Directory of Open Access Journals (Sweden)

    Ivan Ivanov

    2015-10-01

    Full Text Available Purpose: to develop methodical recommendations of the improvement of technical skill at the stage of the specialized basic preparation in fitness by means of powerlifting. Material and Methods: masters of sports in powerlifting and candidates for the master of sports in powerlifting – members of a national team on weightlifting and powerlifting of the Kharkov area took part in the research. Methods were used: theoretical analysis and generalization, analysis of scientific literature, pedagogical supervision, pedagogical experiment, video registration method, methods of mathematical statistics. Results: we developed a number of methodical recommendations which are submitted on finishing technical skill on the basis of the analysis of technique of a performance of the competitive exercise deadlift which is made by means of the program Dartfish by highly skilled sportsmen. As a result of the experiment it is established that the gain of result was more significant in the experimental group which was engaged by the developed technique. Conclusions: it is experimentally proved that the use of computer programs of video registration allows improving qualitatively the feedback between a coach and a sportsman, optimizing the process of training of a sportsman and correction of his technique, increasing the gain of sports result

  3. 77 FR 39226 - Applications for New Awards: Technical Assistance and Dissemination To Improve Services and...

    Science.gov (United States)

    2012-07-02

    ...., Chijioke, C. and Barber, M. (2010). How the World's Most Improved School Systems Keep Getting Better..., L. (2009). The Role of Teachers' Psychological Experiences and Perceptions of Curriculum Supports on...

  4. Technical Network

    CERN Multimedia

    2007-01-01

    In order to optimize the management of the Technical Network (TN), to ease the understanding and purpose of devices connected to the TN, and to improve security incident handling, the Technical Network Administrators and the CNIC WG have asked IT/CS to verify the "description" and "tag" fields of devices connected to the TN. Therefore, persons responsible for systems connected to the TN will receive email notifications from IT/CS asking them to add the corresponding information in the network database. Thank you very much for your cooperation. The Technical Network Administrators & the CNIC WG

  5. Technical Network

    CERN Multimedia

    2007-01-01

    In order to optimise the management of the Technical Network (TN), to facilitate understanding of the purpose of devices connected to the TN and to improve security incident handling, the Technical Network Administrators and the CNIC WG have asked IT/CS to verify the "description" and "tag" fields of devices connected to the TN. Therefore, persons responsible for systems connected to the TN will receive e-mails from IT/CS asking them to add the corresponding information in the network database at "network-cern-ch". Thank you very much for your cooperation. The Technical Network Administrators & the CNIC WG

  6. Identifying non-technical skills and barriers for improvement of teamwork in cardiac arrest teams

    DEFF Research Database (Denmark)

    Andersen, P.O.; Jensen, Michael Kammer; Lippert, A.

    2010-01-01

    2006 to November 2006. Interviews were focussed on barriers and recommendations for teamwork in the cardiac arrest team, optimal policy for improvement of resuscitation training and clinical practice, use of cognitive aids and adoption of European Resuscitation Council (ERC) Guidelines 2005. Interviews...... management. Important barriers that were identified were inexperienced team leaders, task overload and hierarchic structure in the teams' inability to maintain focus on chest compressions. Conclusion: Interview participants pointed out that NTSs of teams could improve the treatment of cardiac arrest...

  7. Training of technical staff and technical staff managers

    International Nuclear Information System (INIS)

    Moody, G.F.

    1991-01-01

    The purpose of Technical Staff and Technical Staff Managers training is to provide job skills enhancement to individuals selected to fill key technical positions within a nuclear utility. This training is unique in that unlike other training programs accredited by the National Academy for Nuclear Training, it does not lead to specific task qualification. The problems encountered when determining the student population and curriculum are a direct result of this major difference. Major problems encountered are determining who should attend the training, what amount of training is necessary and sufficient, and how to obtain the best feedback in order to effect substantive program improvements. These topics will be explored and possible solutions discussed

  8. Dynamic CT perfusion imaging of the myocardium: a technical note on improvement of image quality.

    Directory of Open Access Journals (Sweden)

    Daniela Muenzel

    Full Text Available OBJECTIVE: To improve image and diagnostic quality in dynamic CT myocardial perfusion imaging (MPI by using motion compensation and a spatio-temporal filter. METHODS: Dynamic CT MPI was performed using a 256-slice multidetector computed tomography scanner (MDCT. Data from two different patients-with and without myocardial perfusion defects-were evaluated to illustrate potential improvements for MPI (institutional review board approved. Three datasets for each patient were generated: (i original data (ii motion compensated data and (iii motion compensated data with spatio-temporal filtering performed. In addition to the visual assessment of the tomographic slices, noise and contrast-to-noise-ratio (CNR were measured for all data. Perfusion analysis was performed using time-density curves with regions-of-interest (ROI placed in normal and hypoperfused myocardium. Precision in definition of normal and hypoperfused areas was determined in corresponding coloured perfusion maps. RESULTS: The use of motion compensation followed by spatio-temporal filtering resulted in better alignment of the cardiac volumes over time leading to a more consistent perfusion quantification and improved detection of the extend of perfusion defects. Additionally image noise was reduced by 78.5%, with CNR improvements by a factor of 4.7. The average effective radiation dose estimate was 7.1±1.1 mSv. CONCLUSION: The use of motion compensation and spatio-temporal smoothing will result in improved quantification of dynamic CT MPI using a latest generation CT scanner.

  9. Dynamic CT Perfusion Imaging of the Myocardium: A Technical Note on Improvement of Image Quality

    Science.gov (United States)

    Gramer, Bettina; Leber, Vivian; Vembar, Mani; Schmitt, Holger; Wildgruber, Moritz; Fingerle, Alexander A.; Rummeny, Ernst J.; Huber, Armin; Noël, Peter B.

    2013-01-01

    Objective To improve image and diagnostic quality in dynamic CT myocardial perfusion imaging (MPI) by using motion compensation and a spatio-temporal filter. Methods Dynamic CT MPI was performed using a 256-slice multidetector computed tomography scanner (MDCT). Data from two different patients–with and without myocardial perfusion defects–were evaluated to illustrate potential improvements for MPI (institutional review board approved). Three datasets for each patient were generated: (i) original data (ii) motion compensated data and (iii) motion compensated data with spatio-temporal filtering performed. In addition to the visual assessment of the tomographic slices, noise and contrast-to-noise-ratio (CNR) were measured for all data. Perfusion analysis was performed using time-density curves with regions-of-interest (ROI) placed in normal and hypoperfused myocardium. Precision in definition of normal and hypoperfused areas was determined in corresponding coloured perfusion maps. Results The use of motion compensation followed by spatio-temporal filtering resulted in better alignment of the cardiac volumes over time leading to a more consistent perfusion quantification and improved detection of the extend of perfusion defects. Additionally image noise was reduced by 78.5%, with CNR improvements by a factor of 4.7. The average effective radiation dose estimate was 7.1±1.1 mSv. Conclusion The use of motion compensation and spatio-temporal smoothing will result in improved quantification of dynamic CT MPI using a latest generation CT scanner. PMID:24130697

  10. Improved Structure and Fabrication of Large, High-Power KHPS Rotors - Final Scientific/Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Corren, Dean [Verdant Power, Inc.; Colby, Jonathan [Verdant Power, Inc.; Adonizio, Mary Ann [Verdant Power, Inc.

    2013-01-29

    Verdant Power, Inc, working in partnership with the National Renewable Energy Laboratory (NREL), Sandia National Laboratories (SNL), and the University of Minnesota St. Anthony Falls Laboratory (SAFL), among other partners, used evolving Computational Fluid Dynamics (CFD) and Finite Element Analysis (FEA) models and techniques to improve the structure and fabrication of large, high-power composite Kinetic Hydropower System (KHPS) rotor blades. The objectives of the project were to: design; analyze; develop for manufacture and fabricate; and thoroughly test, in the lab and at full scale in the water, the improved KHPS rotor blade.

  11. How do technical improvements change radiographers' practice – A practice theory perspective

    International Nuclear Information System (INIS)

    Lundvall, L.-L.; Abrandt-Dahlgren, M.; Wirell, S.

    2015-01-01

    Introduction: The two plane imaging techniques are gradually being replaced by multidimensional imaging. How it affects radiographers' professional practice has not been investigated. Aim: To explore how technical development affects the relations between different actors and their actions in the practice of Computer Tomography. Method: A qualitative design with data collection by open interviews (n = 8) and open observations (n = 10) of radiographers during their work with Computer Tomography. Data was first analyzed inductively resulting in seven codes. Secondly abduction was carried out by interpreting the content in the codes with a practice theory. This resulted in four themes. Result: First theme: Changed materiality makes the practical action easier. The actual image production has become practically easier. Second theme: Changed machines cause conflict between the arrangements of the work and the patients' needs. The time for the machine to carry out image production is easy to foresee, but information about the patient's individual status and needs is missing and this leads to difficulties in giving individual planned care. Third theme: Changing materiality prefigure learning. The different apparatus in use and the continuously changing methods of image production is co-constitutive of the practitioners' activities and learning. Fourth theme: Radiography is arranged for patient safety in relation to radiation doses and medical security risks. But the radiographers, who meet the patients, have to check the accuracy of the planned examination in relation to the clinical observed information about patient safety risks with the examination. - Highlights: • The arrangements of CT practice make it difficult to achieve individual planned care. • Continuously learning has become an essential part of radiographers' practice. • Radiographers' planning of each examination is important for secure patient safety

  12. Technical development of PubMed interact: an improved interface for MEDLINE/PubMed searches.

    Science.gov (United States)

    Muin, Michael; Fontelo, Paul

    2006-11-03

    The project aims to create an alternative search interface for MEDLINE/PubMed that may provide assistance to the novice user and added convenience to the advanced user. An earlier version of the project was the 'Slider Interface for MEDLINE/PubMed searches' (SLIM) which provided JavaScript slider bars to control search parameters. In this new version, recent developments in Web-based technologies were implemented. These changes may prove to be even more valuable in enhancing user interactivity through client-side manipulation and management of results. PubMed Interact is a Web-based MEDLINE/PubMed search application built with HTML, JavaScript and PHP. It is implemented on a Windows Server 2003 with Apache 2.0.52, PHP 4.4.1 and MySQL 4.1.18. PHP scripts provide the backend engine that connects with E-Utilities and parses XML files. JavaScript manages client-side functionalities and converts Web pages into interactive platforms using dynamic HTML (DHTML), Document Object Model (DOM) tree manipulation and Ajax methods. With PubMed Interact, users can limit searches with JavaScript slider bars, preview result counts, delete citations from the list, display and add related articles and create relevance lists. Many interactive features occur at client-side, which allow instant feedback without reloading or refreshing the page resulting in a more efficient user experience. PubMed Interact is a highly interactive Web-based search application for MEDLINE/PubMed that explores recent trends in Web technologies like DOM tree manipulation and Ajax. It may become a valuable technical development for online medical search applications.

  13. The effect of test specifications review on improving the quality of a test

    Directory of Open Access Journals (Sweden)

    Hamed Zandi

    2014-01-01

    Full Text Available Reviewing the test specifications to improve the quality of language tests may be a routine process in professional testing systems. However, there is a paucity of research about the effect of specifications review on improving the quality of small-scale tests. The purpose of the present study was twofold: how specifications review could help improve the validity of a test in the context of assessment for learning (AFL and to what extent qualitative review of items can identify poor ones. To this end, a group of trained test specifications reviewers (No = 7 provided feedback on the specifications of a test and the quality of the items. Analysis of feedback showed that pedagogical concerns naturally emerged during the specifications review and led to concrete suggestions on how the specifications could be revised so that the resulting test could become more useful in a classroom context. Moreover, the test items were administered to a group of (No = 40 test-takers and a set of quantitative item analyses was carried out. Comparison of the results of qualitative judgment of reviewers with the quantitative analyses showed about 38 % of the items suggested for revision by the reviewers were also identified as poor by the classical test theory (CTT analysis. The findings highlight the potential of specifications review as part of the a priori validation of tests in small-scale assessments where conducting statistical analysis is not usually feasible.

  14. Federal and State Roles and Capacity for Improving Schools. Technical Report

    Science.gov (United States)

    Gottfried, Michael A.; Stecher, Brian M.; Hoover, Matthew; Cross, Amanda Brown

    2011-01-01

    U.S. educators and policymakers are concerned about the poor performance of the public schools, particularly schools that serve students from low-income families. Although education is primarily a state function, the federal government also has a longstanding interest in improving education for disadvantaged students, and it targets funding to…

  15. Identifying non-technical skills and barriers for improvement of teamwork in cardiac arrest teams

    DEFF Research Database (Denmark)

    Andersen, P.O.; Jensen, Michael Kammer; Lippert, A.

    2010-01-01

    2006 to November 2006. Interviews were focussed on barriers and recommendations for teamwork in the cardiac arrest team, optimal policy for improvement of resuscitation training and clinical practice, use of cognitive aids and adoption of European Resuscitation Council (ERC) Guidelines 2005. Interviews...

  16. Factors Influencing Team Performance in a Continuous Quality Improvement Process in the Wisconsin Technical College System

    Science.gov (United States)

    Pietz, Victoria Lynn

    2014-01-01

    Continuous Quality Improvement (CQI) programs are growing in popularity in higher education settings and a key component is the use of work groups, which require active employee involvement. The problem addressed in this research was the lack of employee engagement in the Quality Review Process (QRP), which is a statewide CQI model developed by…

  17. Progress in improving provincial plans for nutrition through targeted technical assistance and local advocacy in Vietnam.

    Science.gov (United States)

    Harris, Jody; Nguyen, Phuong H; To, Quyen; Frongillo, Edward A; Menon, Purnima

    2016-12-01

    Vietnam has been decentralizing nutrition planning to provinces, which could help with local relevance and accountability. Assessment in 2009 found a continuing top-down approach, limited human capacity, and difficulty in integrating multiple sectors. Alive and Thrive (A&T) provided targeted assistance and capacity-building for 15 provincial plans for nutrition (PPNs). We aimed to (i) assess PPN content and quality improvements 2009-2014, and (ii) explain processes through which change occurred. Data consisted of interview-based assessments of provincial planning processes, annual PPN assessments, and tracking of A&T involvement. At endline, some provinces produced higher quality plans. Local planning skills improved, but capacity remained insufficient. Awareness of and support for nutrition improved, but some policy and legal environments were contradictory. Objectives were clearer, but use of data for planning remained inconsistent. Provinces became more proactive and creative, but remained constrained by slow approval processes and insufficient funding. Targeted assistance and local advocacy can improve decentralized planning, with success dependent on policy and programming contexts and ability to overcome constraints around capacity, investment, data use and remnants of centralized planning. We recommend strong engagement with planners at the national level to understand how to unblock major constraints; solutions must take into consideration the particular political, financial and administrative context. © The Author 2016. Published by Oxford University Press in association with The London School of Hygiene and Tropical Medicine.

  18. A Critical Thinking Map to Improve Content Area Comprehension of Poor Readers. Technical Report No. 402.

    Science.gov (United States)

    Idol, Lorna

    A mapping strategy for improving critical thinking about expository text was employed in a study designed to help six high school students with difficulties in reading comprehension. Subjects were four sophomores in a remedial reading program and two juniors in a special education program for the mildly retarded. Subjects read passages from an…

  19. The utility of endovascular simulation to improve technical performance and stimulate continued interest of preclinical medical students in vascular surgery.

    Science.gov (United States)

    Lee, Jason T; Qiu, Mary; Teshome, Mediget; Raghavan, Shyam S; Tedesco, Maureen M; Dalman, Ronald L

    2009-01-01

    New training paradigms in vascular surgery allow for early specialization out of medical school. Surgical simulation has emerged as an educational tool for trainees to practice procedures in a controlled environment allowing interested medical students to perform procedures without compromising patient safety. The purpose of this study is to assess the ability of a simulation-based curriculum to improve the technical performance and interest level of medical students in vascular surgery. Prospective observational cohort study of medical student performance. Academic medical center. Forty-one medical students (23 first year, 15 second year, 3 other) enrolled in a vascular surgery elective course. Students completed a survey of their interests and performed a renal stent procedure on an endovascular simulator (pretest). The curriculum consisted of didactic teaching and weekly mentored simulator sessions and concluded with a final renal stent procedure on the simulator (posttest). Objective procedural measures were determined during the pre- and posttest by the simulator, and subjective performance was graded by expert observers utilizing a structured global assessment scale. After the course, the students were surveyed as to their opinions about vascular surgery as a career option. Finally, 1 year after the course, all students were again surveyed to determine continued interest in vascular surgery. The objective and subjective criteria measured on the simulator and structured global assessment scale significantly improved from pre- to posttest in terms of performer technical skill, patient safety measures, and structured global assessments. Before beginning the course, 8.5% of the students expressed high interest in vascular surgery, and after completing the course 70% were seriously considering vascular surgery as a career option (p = 0.0001). More than 95% of the students responded that endovascular simulation increased their knowledge and interest in vascular

  20. Improving SPAWAR PEO C4I Organizational Alignment to Better Enable Enterprise Technical Risk Management

    Science.gov (United States)

    2017-03-01

    organizational structures best support meeting specific performance goals, and some of the aspects that are focused on maximizing a risk management strategy...Dickinson 2001). The principles of risk management do not necessarily change when implemented at the enterprise level, but the involved participants...employed by the Department of Defense and the goals of each organization with regard to risk management . It should be noted that the top -level

  1. A case study of the counterpart technical support policy to improve rural health services in Beijing

    Directory of Open Access Journals (Sweden)

    Jian Weiyan

    2012-12-01

    Full Text Available Abstract Background There is, globally, an often observed inequality in the health services available in urban and rural areas. One strategy to overcome the inequality is to require urban doctors to spend time in rural hospitals. This approach was adopted by the Beijing Municipality (population of 20.19 million to improve rural health services, but the approach has never been systematically evaluated. Methods Drawing upon 1.6 million cases from 24 participating hospitals in Beijing (13 urban and 11 rural hospitals from before and after the implementation of the policy, changes in the rural–urban hospital performance gap were examined. Hospital performance was assessed using changes in six indices over-time: Diagnosis Related Groups quantity, case-mix index (CMI, cost expenditure index (CEI, time expenditure index (TEI, and mortality rates of low- and high-risk diseases. Results Significant reductions in rural–urban gaps were observed in DRGs quantity and mortality rates for both high- and low-risk diseases. These results signify improvements of rural hospitals in terms of medical safety, and capacity to treat emergency cases and more diverse illnesses. No changes in the rural–urban gap in CMI were observed. Post-implementation, cost and time efficiencies worsened for the rural hospitals but improved for urban hospitals, leading to a widening rural–urban gap in hospital efficiency. Conclusions The strategy for reducing urban–rural gaps in health services adopted, by the Beijing Municipality shows some promise. Gains were not consistent, however, across all performance indicators, and further improvements will need to be tried and evaluated.

  2. Technical improvement to prevent DNA degradation of Leptospira spp. in pulsed field gel electrophoresis.

    Science.gov (United States)

    Ribeiro, R L; Machry, L; Brazil, J M V; Ramos, T M V; Avelar, K E S; Pereira, M M

    2009-08-01

    Leptospirosis is a public health problem. Infection with pathogenic Leptospira occurs by exposure to many environments and is traditionally associated with occupational risk activities. Pulsed-field gel electrophoresis was used to investigate the epidemiological relatedness among Leptospira isolates. However, analysis by PFGE yielded inconclusive data as a result of extensive DNA degradation. This degradation can be significantly reduced by the inclusion of thiourea in the electrophoresis buffer, improving the analysis of DNA banding patterns.

  3. Technical aspects of typing for HLA-DP alleles using allele-specific DNA in vitro amplification and sequence-specific oligonucleotide probes. Detection of single base mismatches

    DEFF Research Database (Denmark)

    Fugger, L; Morling, N; Ryder, L P

    1990-01-01

    The polymerase chain reaction (PCR) is an effective method for in vitro DNA amplification which combined with probing with synthetic oligonucleotides can be used for, e.g., HLA-typing. We have studied the technical aspects of HLA-DP typing with the technique. DNA from mononuclear nucleated cells...... was extracted with either a simple salting out method or phenol/chloroform. Both DNAs could be readily used for PCR. The MgC2 concentration of the PCR buffer and the annealing temperature of the thermal cycle of the PCR were the two most important variables. The MgCl2 concentration and the temperature must...... be carefully titrated for each primer pair in the PCR. The influence of mismatches between the primer and the DNA template were studied and we found that, by using primers differing only from each other at the 3' end, cross-amplification of closely homologous alleles could be avoided. Thus, single base...

  4. PHYLLOXERA-RESISTANT HYBRID FORM OF GRAPES OF TECHNICAL SORTS FOR IMPROVING THE ASSORTMENT

    OpenAIRE

    Larkina M. D.; Nikulushkina G. E.

    2015-01-01

    Many old varieties of grapes do not meet modern requirements, so there is a need for improved assortment of new high-quality varieties. The translation of the vineyards of the black sea coast of the Krasnodar region on inoculated culture is not fully decided the fate of the viticulture of the area. Weak resistance of American rootstocks to increased content of calcium and salts in the soil, caused the weakening of the bushes, reducing the vigor of the shoots, their maturation and yield of gra...

  5. Structured training on the da Vinci Skills Simulator leads to improvement in technical performance of robotic novices.

    Science.gov (United States)

    Walliczek-Dworschak, U; Mandapathil, M; Förtsch, A; Teymoortash, A; Dworschak, P; Werner, J A; Güldner, C

    2017-02-01

    The increasing use of minimally invasive techniques such as robotic-assisted devices raises the question of how to acquire robotic surgery skills. The da Vinci Skills Simulator has been demonstrated to be an effective training tool in previous reports. To date, little data are available on how to acquire proficiency through simulator training. We investigated the outcome of a structured training programme for robotic surgical skills by robotic novices. This prospective study was conducted from January to December 2013 using the da Vinci Skills Simulator. Twenty participants, all robotic novices, were enrolled in a 4-week training curriculum. After a brief introduction to the simulator system, three consecutive repetitions of five selected exercises (Match Board 1, 2, 3 and Ring and Rail 1, 2) were performed in a defined order on days 1, 8, 15 and 22. On day 22, one repetition of a previously unpractised more advanced module (Needle Targeting) was also performed. After completion of each study day, the overall performance, time to completion, economy in motion, instrument collisions, excessive instrument force, instruments out of view, master workspace range and number of drops were analysed. Comparing the first and final repetition, overall score and time needed to complete all exercises, economy of motion and instrument collisions were significantly improved in nearly all exercises. Regarding the new exercise, a positive training effect could be demonstrated. While its overall entry score was significantly higher, the time to completion and economy of motion were significantly lower than the scores on the first repetition of the previous 5 exercises. It could be shown that training on the da Vinci Skills Simulator led to an improvement in technical performance of robotic novices. With regard to a new exercise, the training had a positive effect on the technical performance. © 2016 John Wiley & Sons Ltd.

  6. THE USE OF TECHNICAL KNOWLEDGE AS DIRECTED TO THE IMPROVEMENT OF EVOLUTIONARY PROCESSES AND DECISION MAKING

    Directory of Open Access Journals (Sweden)

    Liane Mahlmann Kipper

    2013-07-01

    Full Text Available In the current scenario of organizations Process Management aims to perform process in an organized, prioritizing actions through techniques and methods that are linked to the improvement of the organization in the market segment it operates. As a determinant for achieving goals successfully, organizational memory is all important in the management of processes, allowing all areas meet in a systemic way, crediting their information to the various organizational sectors and thus using knowledge to direct an action with a focus planning to achieve strategic organizational goal. The organizational memory can be registered through the development of a knowledge base. The work in question aims to provide a better understanding of the importance of the knowledge base in an organization, to perform appropriate actions, planning, simulating and reaching a decision through meaningful data. Soon after the development of a bibliographic research, a bibliometric study on the proposed topic was accomplished with the main events of the Brazilian scientific areas of production engineering, analyzing how the topic has been addressed by authors in the areas of Process Management and Base Knowledge. The main results so far observed the need for the implementation of knowledge-based models in systems that seek to improve the execution of processes and thus reduce failures and decision-making processes more appropriate.

  7. Improving integration and coordination of funding, technical assistance, and reporting/data collection: recommendations from CDC and USAPI stakeholders.

    Science.gov (United States)

    Ka'opua, Lana Sue I; White, Susan F; Rochester, Phyllis F; Holden, Debra J

    2011-03-01

    Current US Federal funding mechanisms may foster program silos that disable sharing of resources and information across programs within a larger system of public health services. Such silos present challenges to USAPI communities where human resources, health infrastructure, and health financing are limited. Integrative and coordinated approaches have been recommended. The CDC Pacific Islands Integration and Coordination project was initiated by the CDC Division of Cancer Prevention and Control (DCPC). The project aim was to identify ways for the CDC to collaborate with the USAPI in improving CDC activities and processes related to chronic disease. This article focuses on recommendations for improving coordination and integration in three core areas of health services programming: funding, program reporting/data collection and analysis, and technical assistance. Preliminary information on challenges and issues relevant to the core areas was gathered through site visits, focus groups, key informant interviews, and other sources. This information was used by stakeholder groups from the CDC and the USAPI to develop recommendations in the core programming areas. Recommendations generated at the CDC and USAPI stakeholder meetings were prepared into a single set of recommendations and stakeholders reviewed the document for accuracy prior to its dissemination to CDC's National Center for Chronic Disease Prevention and Health Promotion programs management and staff. Key recommendations, include: (1) consideration of resources and other challenges unique to the USAPI when reviewing funding applications, (2) consideration of ways to increase flexibility in USAPI use of program funds, (3) dedication of funding and human resources for technical assistance, (4) provision of opportunities for capacity-building across programs and jurisdictions, (5) consideration of ways to more directly link program reporting with technical assistance. This project provided a unique opportunity

  8. UK: Technical data for waste incineration background for modelling of product-specific emissions in a life cycle assessment context

    DEFF Research Database (Denmark)

    Hauschild, Michael Zwicky

    with the disposal of a product through waste incineration. Based on knowledge of the material composition of the product and the technology applied in the waste incineration plant, the model estimates input of energy and auxiliary materials required for the incineration of the product and generation of energy...... and output of emissions to the environment caused by the incineration. The work has been performed as part of the EUREKA project EUROENVIRON 1296: LCAGAPS, sponsored by the Danish Agency for Industry and Trade. This report presents a compilation of technical data on waste incineration that serve...... as background for a model of incineration processes to be used in the inventory analysis of LCA....

  9. Scientific/Technical Report: Improvement in compensation and crystal growth of cadmium zinc telluride radiation detectors

    International Nuclear Information System (INIS)

    Kelvin G. Lynn; Kelly A. Jones

    2007-01-01

    was a single crystal except on the edges. We consider that single crystals are necessary but are not yet the key to the best radiation response. Starting this with very few changes we were unable to reproduce the single crystal in CG40. (4) CZT defect characterization--Upgraded defect characterization techniques and tools were implemented as well improving the cutting process to reduce damage. An automated thermoelectric effect spectroscopy (TEES) and thermally stimulated current (TSC) machine was modified and tested.. Infrared transmission microscopy was improved to better analyze the role of these inclusions. These three devices improved defect analysis capabilities and helped produce a presentation

  10. Technical Improvements to an Absorbing Supergel for Radiological Decontamination in Tropical Environments

    Energy Technology Data Exchange (ETDEWEB)

    Kaminski, Michael D. [Argonne National Lab. (ANL), Argonne, IL (United States); Mertz, Carol J. [Argonne National Lab. (ANL), Argonne, IL (United States); Kivenas, Nadia [Argonne National Lab. (ANL), Argonne, IL (United States); demmer, Rick [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-01-01

    Argonne National Laboratory (Argonne) developed a superabsorbing gel-based process (SuperGel) for the decontamination of cesium from concrete and other porous building materials. Here, we report on results that tested the gel decontamination technology on specific concrete and ceramic formulations from a coastal city in Southeast Asia, which may differ significantly from some U.S. sources. Results are given for the evaluation of americium and cesium sequestering agents that are commercially available at a reasonable cost; the evaluation of a new SuperGel formulation that combines the decontamination properties of cesium and americium; the variation of the contamination concentration to determine the effects on the decontamination factors with concrete, tile, and brick samples; and pilot-scale testing (0.02–0.09 m2 or 6–12 in. square coupons).

  11. Flue gas conditioning for improved particle collection in electrostatic precipitators. Quarterly technical report

    Energy Technology Data Exchange (ETDEWEB)

    Durham, M.D.

    1992-04-27

    The purpose of this research program is to identify and evaluate a variety of additives capable of increasing particle cohesion which could be used for improving collection efficiency in an ESP. A three-phase screening process will be used to provide the, evaluation of many additives in a logical and cost-effective manner. The three step approach involves the following experimental setups: 1. Provide a preliminary screening in the laboratory by measuring the effects of various conditioning agents on reentrainment of flyash particles in an electric field operating at simulated flue gas conditions. 2. Evaluate the successful additives using a 100 acfm bench-scale ESP operating on actual flue gas. 3. Obtain the data required for scaling up the technology by testing the two or three most promising conditioning agents at the pilot scale.

  12. Technical Note: Improving the VMERGE treatment planning algorithm for rotational radiotherapy

    International Nuclear Information System (INIS)

    Gaddy, Melissa R.; Papp, Dávid

    2016-01-01

    Purpose: The authors revisit the VMERGE treatment planning algorithm by Craft et al. [“Multicriteria VMAT optimization,” Med. Phys. 39, 686–696 (2012)] for arc therapy planning and propose two changes to the method that are aimed at improving the achieved trade-off between treatment time and plan quality at little additional planning time cost, while retaining other desirable properties of the original algorithm. Methods: The original VMERGE algorithm first computes an “ideal,” high quality but also highly time consuming treatment plan that irradiates the patient from all possible angles in a fine angular grid with a highly modulated beam and then makes this plan deliverable within practical treatment time by an iterative fluence map merging and sequencing algorithm. We propose two changes to this method. First, we regularize the ideal plan obtained in the first step by adding an explicit constraint on treatment time. Second, we propose a different merging criterion that comprises of identifying and merging adjacent maps whose merging results in the least degradation of radiation dose. Results: The effect of both suggested modifications is evaluated individually and jointly on clinical prostate and paraspinal cases. Details of the two cases are reported. Conclusions: In the authors’ computational study they found that both proposed modifications, especially the regularization, yield noticeably improved treatment plans for the same treatment times than what can be obtained using the original VMERGE method. The resulting plans match the quality of 20-beam step-and-shoot IMRT plans with a delivery time of approximately 2 min.

  13. WHO Working Group on Technical Specifications for Manufacture and Evaluation of Yellow Fever Vaccines, Geneva, Switzerland, 13-14 May 2009.

    Science.gov (United States)

    Ferguson, Morag; Shin, Jinho; Knezevic, Ivana; Minor, Philip; Barrett, Alan

    2010-12-06

    In May 2009, WHO convened a meeting of Working Group on Technical Specifications for Manufacturing and Evaluating Yellow Fever (YF) Vaccines, Geneva, Switzerland to initiate revision of the WHO Recommendations (formerly, Requirements) for YF vaccine published in WHO Technical Report Series number 872 (1998). The Working Group, consisting of experts from academia, industry, national regulatory authorities and national control laboratories, reviewed the latest issues of safety, efficacy and quality of YF vaccines and agreed that (i) the revision should focus on live attenuated YF vaccine virus 17D lineage; and that (ii) nonclinical and clinical guidelines for new vaccines prepared from 17D lineage be developed. Copyright © 2010. Published by Elsevier Ltd.. All rights reserved.

  14. Assessment, Problems and Ways of Improvement of Technical Regulation of Foreign Economic Activity (FEA in the World

    Directory of Open Access Journals (Sweden)

    Steblyanko Maryna D.

    2013-12-01

    Full Text Available The article analyses the state of technical regulation of FEA in the world and Ukraine and identifies main problems and ways of increase of efficiency of certification. It considers the system of technical regulation of EU and provides examples of application of technical barriers by some countries for ensuring security of goods in the domestic market. The article offers to develop a strategy of development of the national system of information provision of technical regulation and suspend transition from the system of mandatory certification to the system of assessment of correspondence with requirements of technical orders of business.

  15. Final Technical Report for Project 'Improving the Simulation of Arctic Clouds in CCSM3 (SGER Award)'

    International Nuclear Information System (INIS)

    Vavrus, Stephen J.

    2008-01-01

    This project has focused on the simulation of Arctic clouds in CCSM3 and how the modeled cloud amount (and climate) can be improved substantially by altering the parameterized low cloud fraction. The new formula, dubbed 'freeezedry', alleviates the bias of excessive low clouds during polar winter by reducing the cloud amount under very dry conditions. During winter, freezedry decreases the low cloud amount over the coldest regions in high latitudes by over 50% locally and more than 30% averaged across the Arctic (Fig. 1). The cloud reduction causes an Arctic-wide drop of 15 W m -2 in surface cloud radiative forcing (CRF) during winter and about a 50% decrease in mean annual Arctic CRF. Consequently, wintertime surface temperatures fall by up to 4 K on land and 2-8 K over the Arctic Ocean, thus significantly reducing the model's pronounced warm bias (Fig. 1). While improving the polar climate simulation in CCSM3, freezedry has virtually no influence outside of very cold regions (Fig. 2) or during summer (Fig. 3), which are space and time domains that were not targeted. Furthermore, the simplicity of this parameterization allows it to be readily incorporated into other GCMs, many of which also suffer from excessive wintertime polar cloudiness, based on the results from the CMIP3 archive (Vavrus et al., 2008). Freezedry also affects CCSM3's sensitivity to greenhouse forcing. In a transient-CO 2 experiment, the model version with freezedry warms up to 20% less in the North Polar and South Polar regions (1.5 K and 0.5 K smaller warming, respectively) (Fig. 4). Paradoxically, the muted high-latitude response occurs despite a much larger increase in cloud amount with freezedry during non-summer months (when clouds warm the surface), apparently because of the colder modern reference climate. These results of the freezedry parameterization have recently been published (Vavrus and D. Waliser, 2008: An improved parameterization for simulating Arctic cloud amount in the CCSM3

  16. Production-Based Education Model for Improving Technical and Vocational Teachers Ability

    Science.gov (United States)

    Saputro, H.; Suharno; Widiastuti, I.; Harjanto, B.

    2018-02-01

    The vocational high schools (SMK) in Surakarta have applied the Production-Based Education (PBE) in order to improve the student skills. On the other hand, the implementation of PBE model is needed the professional teachers who have the skill qualifications in the production and learning. This study focuses on strengthening of teacher’s behavior related to the implementation of PBE model at vocational high schools in Surakarta, especially on teacher’s Organizational Citizenship Behavior. This research conducted based on the observational research method that employed 134 teachers of SMK Warga Surakarta as respondents. The data of teachers OCB were analyzed by using the descriptive analysis. The result showed that the PBE model had strengthened the teachers OCB at SMK Warga Surakarta. The measurements of OCB level of SMK teachers had shown the high (H) level and some of the teachers’ OCB characters show very high (VH) levels such as altruism and civic virtue. OCB or “good soldier syndrome” could be manifested by the teacher’s interaction at school such as loyalty, volunteering and helping others. Therefore, teacher’s OCB behavior became important due to the organizational effectiveness at vocational high school (SMK).

  17. Using domain specific languages to improve the development of a power control unit

    NARCIS (Netherlands)

    Schuts, M.; Hooman, J.

    2015-01-01

    To improve the design of a power control unit at Philips, two Domain Specific Languages (DSLs) have been used. The first DSL provides a concise and readable notation for the essential state transitions. It is used to generate both configuration files and analysis models. In addition, we also

  18. Technical specifications Limerick Generating Station, Unit No.1 (Docket No. 50-352). Appendix ''A'' to License No. NPF-39

    International Nuclear Information System (INIS)

    1985-06-01

    The specifications include: definitions, safety limits and limiting safety system settings, bases, limiting conditions for operation and surveillance requirements, design features, and administrative controls

  19. Dual energy CTA of the supraaortic arteries: Technical improvements with a novel dual source CT system

    International Nuclear Information System (INIS)

    Lell, Michael M.; Hinkmann, Fabian; Nkenke, Emeka; Schmidt, Bernhard; Seidensticker, Peter; Kalender, Willi A.; Uder, Michael; Achenbach, Stephan

    2010-01-01

    Objectives: Computed tomography angiography (CTA) is a well-accepted imaging modality to evaluate the supraaortic vessels. Initial reports have suggested that dual energy CTA (DE-CTA) can enhance diagnosis by creating bone-free data sets, which can be visualized in 3D, but a number of limitations of this technique have also been addressed. We sought to describe the performance of DE-CTA of the supraaortic vessels with a novel dual source CT system with special emphasis on image quality and post-processing related artifacts. Materials and methods: Thirty-three patients underwent carotid CT angiography on a second generation dual source CT system. Simultaneous acquisitions of 100 and 140 kV data sets in arterial phase were performed. Two examiners evaluated overall bone suppression with a 3-point scale (1 = poor; 3 = excellent) and image quality regarding integrity of the vessel lumen of different vessel segments (n = 26) with a 5-point scale (1 = poor; 5 = excellent), CTA source data served as the reference. Results: Excellent bone suppression could be achieved in the head and neck. Only minor bone remnants occurred, mean score for bone removal was 2.9. Mean score for vessel integrity was 4.3. Eight hundred fifty-seven vessel segments could be evaluated. Six hundred thirty-five segments (74%) showed no lumen alteration, 65 segments (7.6%) lumen alterations 10% resulting in a total luminal reduction 50%, and 113 segments (13.2%) showed a gap in the vessel course (100% total lumen reduction). Artificial gaps of the vessel lumen occurred in 28 vessel segments due to artifacts caused by dental hardware and in all but one (65) ophthalmic arteries. Conclusions: Excellent bone suppression could be achieved, DE imaging with 100 and 140 kV lead to improved image quality and vessel integrity in the shoulder region than previously reported. The ophthalmic artery still cannot be adequately visualized.

  20. Improving artificial breeding of cattle in Africa. Guidelines and recommendations. A manual prepared under the framework of an IAEA technical cooperation regional AFRA project on increasing and improving milk and meat production

    International Nuclear Information System (INIS)

    2005-04-01

    The International Atomic Energy Agency (IAEA) and the African Co-operative Agreement for Research, Development and Training Related to Nuclear Science and Technology (AFRA), with technical support from the Joint FAO/IAEA Programme of Nuclear Techniques in Food and Agriculture, implemented a technical cooperation project entitled Improving and Increasing Milk and Meat Production. The objectives of this project were to be achieved by (a) assessing the performance of existing artificial insemination (AI) programmes for small-scale dairy farmers and identifying constraints; (b) formulating and assisting in the implementation of remedial measures including appropriate strategies; (c) establishing sustainable routine non-pregnancy diagnosis (N-PD) and related services to farmers; and (d) harmonizing managerial and field practices and sharing of expertise within the region. The radioimmunoassay (RIA) for measurement of progesterone in milk and blood of cattle and use of the computer database AIDA (Artificial Insemination Database Application) are important components of an integrated approach to these activities. The project commenced in 1999 and, in addition to other national and regional activities, two meetings were held specifically to address objective (d) above: - Task Force Meeting on Training of Artificial Insemination (AI) Technicians, Field Assessment of Fertility and Database Management, November 1999 in Pretoria, South Africa. - Task Force Meeting to Harmonize Procedures for Selection and Management of AI Bulls and Use of Semen Technology in African Countries, May 2001 in Arusha, Tanzania. The meeting in Tanzania provided a comprehensive overview of the current practices being adopted for selection and management of AI bulls and use of semen technology in five African countries, and compared these with international practices. It also provided an opportunity for participants to discuss technical issues related to provision of improved breeding services to

  1. WHO Working Group on technical specifications for manufacture and evaluation of dengue vaccines, Geneva, Switzerland, 11-12 May 2009.

    Science.gov (United States)

    Trent, Dennis; Shin, Jinho; Hombach, Joachim; Knezevic, Ivana; Minor, Philip

    2010-12-06

    In May 2009, a group of international experts on dengue, vaccine quality and clinical evaluation met together (i) to review disease, vaccine pipeline, quality issues in manufacturing, issues of environmental risk assessment, nonclinical and clinical evaluation of live recombinant dengue vaccines and (ii) to initiate revising WHO guidelines for the production and quality control of candidate tetravalent dengue vaccines (live). This report summarizes an exchange of views on scientific and technical issues related to the quality, safety and efficacy of candidate dengue vaccines. Recognizing live dengue vaccines are the major vaccines in the clinical pipeline, the Working Group agreed (i) to focus on live dengue vaccines in the revision of the WHO guidelines and (ii) to add new guidelines on nonclinical and clinical evaluation, and environmental risk assessment for live dengue vaccines in the revision. Copyright © 2010. Published by Elsevier Ltd.. All rights reserved.

  2. Is education associated with improvements in general cognitive ability, or in specific skills?

    Science.gov (United States)

    Ritchie, Stuart J; Bates, Timothy C; Deary, Ian J

    2015-05-01

    Previous research has indicated that education influences cognitive development, but it is unclear what, precisely, is being improved. Here, we tested whether education is associated with cognitive test score improvements via domain-general effects on general cognitive ability (g), or via domain-specific effects on particular cognitive skills. We conducted structural equation modeling on data from a large (n = 1,091), longitudinal sample, with a measure of intelligence at age 11 years and 10 tests covering a diverse range of cognitive abilities taken at age 70. Results indicated that the association of education with improved cognitive test scores is not mediated by g, but consists of direct effects on specific cognitive skills. These results suggest a decoupling of educational gains from increases in general intellectual capacity. (c) 2015 APA, all rights reserved).

  3. Improving hand hygiene at eight hospitals in the United States by targeting specific causes of noncompliance.

    Science.gov (United States)

    Chassin, Mark R; Mayer, Carrie; Nether, Klaus

    2015-01-01

    Hospitals and infection prevention specialists have attempted to achieve high levels of compliance with hand hygiene protocols for many decades. Despite these efforts, measured performance is disappointingly low. The Joint Commission Center for Transforming Healthcare convened teams of experts in performance improvement and infectious disease from eight hospitals for its hand hygiene quality improvement project, which was conducted from December 2008 through September 2010. Together, they used Lean, Six Sigma, and change management methods to measure the magnitude of hand hygiene noncompliance, assess specific causes of hand hygiene failures, develop and test interventions targeted to specific causes, and sustain improved levels of performance. At baseline, hand hygiene compliance averaged 47.5% across all eight hospitals. Initial data revealed 41 different causes of hand hygiene noncompliance, which were condensed into 24 groups of causes. Key causes varied greatly among the hospitals. Each hospital developed and implemented specific interventions targeted to its most important causes of hand hygiene noncompliance. The improvements were associated with a 70.5% increase in compliance across the eight hospitals from 47.5% to 81.0% ( p < .001), a level of performance that was sustained for 11 months through the end of the project period. Lean, Six Sigma, and change management tools were used to identify specific causes of hand hygiene noncompliance at individual hospitals and target specific interventions to remedy the most important causes. This approach allowed each hospital to customize its improvement efforts by focusing on the causes most prevalent at its own facility. Such a targeted approach may be more effective, efficient, and sustainable than "one-size-fits-all" strategies.

  4. Does a mixed training course on the Oxford unicompartmental knee arthroplasty improve non-technical skills of orthopaedic surgeons?

    Science.gov (United States)

    Alvand, Abtin; Gill, Harinderjit S; Price, Andrew J; Dodd, Christopher A F; Murray, David W; Rees, Jonathan L

    2012-12-01

    To determine whether a mixed course on the Oxford unicompartmental knee arthroplasty (UKA) could improve the non-technical (cognitive) skills of performing UKA. 120 delegates consisting of consultant orthopaedic surgeons and advanced surgical trainees attended a 2-day course. 104 (87%) of the delegates had performed total knee arthroplasties, whereas 79 (66%) had performed UKAs. The course consisted of didactic lectures, interactive surgical demonstrations, and practical dry-bone skills workshops. Cognitive skills were assessed at the start (day 1) and end (day 2) of the course using 10 multiple-choice questions. The maximum test score was 10. Multilevel modelling was used to compare the pre- and post-course test scores. The pairings of pre- and post-course scores were not known because of a confidentiality clause. Of the 120 delegates, 71 (59%) took the pre-course test and 120 (100%) took the post-course test. The median score improved significantly from 2 (interquartile range [IQR], 0.5-3.5) to 6 (IQR, 4.5- 7.5) [bootstrap ptechnical (cognitive) skills for UKA.

  5. Reperfusion of specific cortical areas is associated with improvement in distinct forms of hemispatial neglect.

    Science.gov (United States)

    Khurshid, Shaan; Trupe, Lydia A; Newhart, Melissa; Davis, Cameron; Molitoris, John J; Medina, Jared; Leigh, Richard; Hillis, Argye E

    2012-05-01

    To test the hypothesis that restoring blood flow to specific right cortical regions in acute stroke results in improvement in distinct forms of hemispatial neglect distinguished by reference frame: viewer-centered versus stimulus-centered neglect. Twenty five patients with acute right stroke were evaluated at Day 1 and Day 3-5 with a battery of neglect tests and Diffusion- and Perfusion-Weighted MR Imaging. Multivariate linear regression analysis revealed Brodmann areas (BAs) where reperfusion predicted degree of improvement in scores on each type of neglect, independently of reperfusion of other areas, total change in the volume of infarct or hypoperfusion, and age. Reperfusion of dorsal frontoparietal cortex (including BAs 40, 46, and 4) independently predicted improvement in viewer-centered neglect, such as detecting stimuli on left in line cancellation and scene copying (r=.951; p<.0001). Reperfusion of a more ventral temporo-occipital cortex, including right BAs 37, 38, 21 and 18, independently contributed to improvement in stimulus-centered neglect, such as detecting left gaps in circles (r=.926; p<.0001). Reperfusion of right midfusiform gyrus (temporal occipital cortex), change in total volume of ischemia, change in volume of hypoperfusion and age predicted degree of improvement in reading (reduction in "neglect dyslexic" errors; r=.915; p<.0001). Results demonstrate that reperfusing specific cortical regions yields improvement in different types of neglect. Copyright © 2011 Elsevier Srl. All rights reserved.

  6. Improving the specificity and efficacy of CRISPR/CAS9 and gRNA through target specific DNA reporter

    Science.gov (United States)

    Zhang, Jian-Hua; Pandey, Mritunjay; Kahler, John F.; Loshakov, Anna; Harris, Benjamin; Dagur, Pradeep K.; Mo, Yinyuan; Simonds, William F.

    2014-01-01

    Genomic engineering by the guide RNA (gRNA)-directed CRISPR/CAS9 is rapidly becoming a method of choice for various biological systems. However, pressing concerns remain regarding its off-target activities and wide variations in efficacies. While next generation sequencing (NGS) has been primarily used to evaluate the efficacies and off-target activities of gRNAs, it only detects the imperfectly repaired double strand DNA breaks (DSB) by the error-prone non-homologous end joining (NHEJ) mechanism and may not faithfully represent the DSB activities because the efficiency of NHEJ-mediated repair varies depending on the local chromatin environment. Here we describe a reporter system for unbiased detection and comparison of DSB activities that promises to improve the chance of success in genomic engineering and to facilitate large scale screening of CAS9 activities and gRNA libraries. Additionally, we demonstrated that the tolerances to mismatches between a gRNA and the corresponding target DNA can occur at any position of the gRNA, and depend on both specific gRNA sequences and CAS9 constructs used. PMID:25193712

  7. Technical Specifications, Seabrook Station, Unit 1 (Docket No. 50-443). Appendix ''A'' to License No. NPF-56

    International Nuclear Information System (INIS)

    1986-10-01

    This report provides specifications for the Seabrook Station Unit 1 reactor concerning: safety limits and limiting safety settings; limiting conditions for operation and surveillance requirements; design features; and administrative controls

  8. Technical specifications, South Texas Project, Unit No. 1 (Docket No. 50-498): Appendix ''A'' to License No. NPF-71

    International Nuclear Information System (INIS)

    1987-08-01

    This report presents specifications for the South Texas Project, Unit No. 1 concerning: safety limits, and limiting safety system settings; limiting conditions for operation and surveillance requirements; design features; and administrative controls

  9. Effectiveness of Memantine in Improvement of Cognitive Deficits in Specific Learning Disorder

    Directory of Open Access Journals (Sweden)

    Elham Ahmadi Zahrani

    2016-12-01

    Full Text Available Abstract Background: Specific learning disorder is a neurodevelopmental disorder characterized by persistent difficulties in learning academic skills in reading, written expression, or mathematics. This study was performed to investigate the effectiveness of memantine in the relief of cognitive deficits (selective attention, sustained attention, and working memory in specific learning disorder. Materials and Methods: This study is a clinical trial. Of all children 8-12 years referred to Amir Kabir Hospital 94 patients diagnosed with specific learning disorder based on DSMV diagnostic interview referred by specialist and randomly divided by two groups, memantine and placebo. Cognitive deficits before and after treatment were measured with continuous performance test, Stroop test and Wechsler Digit Span forward and reverse and Corsi test. Results: Multivariate analysis of variance showed a significant difference in error when answering, omission answer and corrected answer in continuous performance test, but this difference is not significant in response time. Difference in forward, reverse and collected auditory was significant and not significant in the auditory span. In active visual working memory at corsi cube test, difference was significant (p <0.05. Conclusion: The results showed that memantine in improvement of sustained attention, auditory working memory and visual working memory, is effective, while in selective attention is not effective and according to similarities of learning disorder and Attention deficit / Hyperactivity disorder (ADHD and the effectiveness of memantine in improvement of symptoms of ADHD, we can also use this drug in improvement of cognitive deficits of specific learning disorder.

  10. Cohort-specific imputation of gene expression improves prediction of warfarin dose for African Americans

    Directory of Open Access Journals (Sweden)

    Assaf Gottlieb

    2017-11-01

    Full Text Available Abstract Background Genome-wide association studies are useful for discovering genotype–phenotype associations but are limited because they require large cohorts to identify a signal, which can be population-specific. Mapping genetic variation to genes improves power and allows the effects of both protein-coding variation as well as variation in expression to be combined into “gene level” effects. Methods Previous work has shown that warfarin dose can be predicted using information from genetic variation that affects protein-coding regions. Here, we introduce a method that improves dose prediction by integrating tissue-specific gene expression. In particular, we use drug pathways and expression quantitative trait loci knowledge to impute gene expression—on the assumption that differential expression of key pathway genes may impact dose requirement. We focus on 116 genes from the pharmacokinetic and pharmacodynamic pathways of warfarin within training and validation sets comprising both European and African-descent individuals. Results We build gene-tissue signatures associated with warfarin dose in a cohort-specific manner and identify a signature of 11 gene-tissue pairs that significantly augments the International Warfarin Pharmacogenetics Consortium dosage-prediction algorithm in both populations. Conclusions Our results demonstrate that imputed expression can improve dose prediction and bridge population-specific compositions. MATLAB code is available at https://github.com/assafgo/warfarin-cohort

  11. Water balance and fertigation for crop improvement in West Asia. Results of a technical co-operation project

    International Nuclear Information System (INIS)

    2002-01-01

    Mediterranean countries have a severe shortage of water resources for agricultural, municipal and industrial purposes. This situation is aggravated daily due to the rapidly increasing population in the area. Agriculture is the biggest consumer of water with about 80% of the renewable resource used for irrigation. Traditional irrigation methods are highly inefficient: only about one-third of the applied water is actually transpired by the crops. Clearly, there is great scope for improved irrigation management. Intensification of agricultural production to meet growing market demand requires the simultaneous application of irrigation water and fertilizers. Application of fertilizer in drip irrigation (fertigation) is an effective way to promote efficient use of these scarce and expensive resources. There is widespread interest in Mediterranean countries in fertigation. Nevertheless, information on the form and concentration of the nutrients required for different crops is presently inadequate. Moreover, the low fertilizer recoveries due to extensive fertilization practiced during the last few decades have created serious agricultural and environmental problems. High nitrate concentrations in groundwater and deterioration of some important quality parameters of agricultural products are the main concerns. Recognizing the potential role of nuclear techniques in identifying improved water and fertilizer management practices, the IAEA implemented two regional technical co-operation projects during the period 1995-2000 with eight participating countries from the West Asia region: The Islamic Republic of Iran, Jordan, Lebanon, Saudi Arabia, the Syria Arab Republic, Turkey, United Arab Emirates and Yemen. The main objective was to establish water balance and fertigation practices using nuclear techniques, with a view to improving crop production in arid and semi-arid zones. The projects aimed to compare the following parameters under conventional fertilizer and water

  12. Blood flow dynamic improvement with aneurysm repair detected by a patient-specific model of multiple aortic aneurysms.

    Science.gov (United States)

    Sughimoto, Koichi; Takahara, Yoshiharu; Mogi, Kenji; Yamazaki, Kenji; Tsubota, Ken'ichi; Liang, Fuyou; Liu, Hao

    2014-05-01

    Aortic aneurysms may cause the turbulence of blood flow and result in the energy loss of the blood flow, while grafting of the dilated aorta may ameliorate these hemodynamic disturbances, contributing to the alleviation of the energy efficiency of blood flow delivery. However, evaluating of the energy efficiency of blood flow in an aortic aneurysm has been technically difficult to estimate and not comprehensively understood yet. We devised a multiscale computational biomechanical model, introducing novel flow indices, to investigate a single male patient with multiple aortic aneurysms. Preoperative levels of wall shear stress and oscillatory shear index (OSI) were elevated but declined after staged grafting procedures: OSI decreased from 0.280 to 0.257 (first operation) and 0.221 (second operation). Graftings may strategically counter the loss of efficient blood delivery to improve hemodynamics of the aorta. The energy efficiency of blood flow also improved postoperatively. Novel indices of pulsatile pressure index (PPI) and pulsatile energy loss index (PELI) were evaluated to characterize and quantify energy loss of pulsatile blood flow. Mean PPI decreased from 0.445 to 0.423 (first operation) and 0.359 (second operation), respectively; while the preoperative PELI of 0.986 dropped to 0.820 and 0.831. Graftings contributed not only to ameliorate wall shear stress or oscillatory shear index but also to improve efficient blood flow. This patient-specific modeling will help in analyzing the mechanism of aortic aneurysm formation and may play an important role in quantifying the energy efficiency or loss in blood delivery.

  13. TECHNICAL ECONOMIC FEASIBILITY OF PADDY RICE FIELDS VARIETY OF APPROACH PTT SPECIFIC LOCATIONS IN PAPUA (Case Jayapura

    Directory of Open Access Journals (Sweden)

    Afrizal Malik

    2013-01-01

    Full Text Available Study aims to determine technical economically feasibility of irrigration rice in village of Sumbe, Namblong District, Jayapura on-farm research involving farmers with an area of 2.50 ha cooperators, July to November 2011. Technology introduced: PTT, 4:1 legowo systems, seed varieties Inpari labeled 1, 2, 4, 6, 7, 9, 10, and Sintanur. Fertilizer: urea 150 kg +100 kg +100 kg SP-36 Phonska KCl +50 kg per ha. Variables: height and number of tillers 35 and 65 dap, weight of 1000 seeds, productivity, input, and output. Data were analyzed descriptively. Highest productivity in varieties Inpari 7 (7.925 tonnes per ha Milled Rice (MR and lowest Sintanur varieties (4.625 tonnes per ha MR. Pest stand: rice leaffolder and stinky rice pest. Lowest expenditure on non-cooperators Ciherang farmers IDR 12.15 million per ha per Growing Season (GS and highest in varieties Inpari 7 (IDR 15,005,000 per ha per GS. Lowest Acceptance Ciherang farmers on non-cooperators, IDR 16.4 million per ha per GS and highest in varieties Inpari 7, IDR 27.7 million per ha per GS. If farmers apply recommendation technologies using Inpari 7 varieties, farmers receiving IDR 3,173,750 per month (greater than Regional Minimum Wage of Jayapura. Need government support in order to minimize dependence on outside

  14. Recycled aggregate in road construction following the Spanish General Technical Specifications for Roads and Bridge Works (PG-3: a case study

    Directory of Open Access Journals (Sweden)

    Martín-Morales, M.

    2013-03-01

    Full Text Available This research characterizes four samples of recycled aggregate for their potential use in road construction projects in consonance with the Spanish General Technical Specifications for Roads and Bridge Works (PG-3. Although some fractions were of sufficient quality for the construction of embankments, backfills, and quarry-run fills, they were ultimately found to be unsuitable for the construction of underground drainage, granular structural layers, soil stabilization and concrete pavements. They were negatively evaluated because of their particle size distribution and sulfate content. Nevertheless, the quality of this recycled aggregate could be substantially improved by manually removing the gypsum before the crushing process at the plant or by selecting the material with greater care at the beginning of the process. Finally, we suggest that Construction and Demolition (C&D waste plant managers should modify the manufacturing process to obtain a suitable particle size distribution in accordance with PG-3 requirements and the projected use of the aggregate.

    En esta investigación se han caracterizado cuatro muestras de árido reciclado para su potencial uso en obras de carreteras en España siguiendo el Pliego de Prescripciones Técnicas Generales para Obras de Carreteras y Puentes (PG-3. Aunque algunas fracciones presentaron suficiente calidad para la construcción de terraplenes, rellenos localizados y rellenos todo en uno, resultaron inadecuadas para la construcción de drenes subterráneos, zahorras, suelos estabilizados y pavimentos de hormigón. Obtuvieron una evaluación negativa en cuanto a distribución granulométrica y contenido en sulfatos. No obstante, la calidad de este árido reciclado podría mejorar sustancialmente eliminando manualmente el yeso antes de la trituración en planta o seleccionando el material con un mayor cuidado al inicio del proceso. Finalmente, recomendamos que los empresarios de las plantas de residuos

  15. Measurement of aberrant glycosylation of prostate specific antigen can improve specificity in early detection of prostate cancer.

    Science.gov (United States)

    Yoneyama, Tohru; Ohyama, Chikara; Hatakeyama, Shingo; Narita, Shintaro; Habuchi, Tomonori; Koie, Takuya; Mori, Kazuyuki; Hidari, Kazuya I P J; Yamaguchi, Maho; Suzuki, Takashi; Tobisawa, Yuki

    2014-06-13

    We previously identified prostate cancer (PCa)-associated aberrant glycosylation of PSA, where α2,3-linked sialylation is an additional terminal N-glycan on free PSA (S2,3PSA). We then developed a new assay system measuring S2,3PSA using a magnetic microbead-based immunoassay. We compared the diagnostic accuracy of conventional PSA and percent-free PSA (%fPSA) tests. We used MagPlex beads to measure serum S2,3PSA levels using anti-human fPSA monoclonal antibody (8A6) for capture and anti-α2,3-linked sialic acid monoclonal antibody (HYB4) for detection. We determined the cutoff values in a training test and measured serum S2,3PSA levels in 314 patients who underwent biopsy, including 138 PCa and 176 non-PCa patients with PSA of presented as mean fluorescence intensity (MFI). Receiver operating characteristic curves were used to evaluate the diagnostic accuracy of total PSA, %fPSA, and S2,3PSA. We determined an MFI cutoff value of 1130 with a sensitivity of 95.0% and specificity of 72.0% for the diagnosis of PCa in the training test. In the validation study, the area under the curve for the detection of PCa with S2,3PSA was 0.84, which was significantly higher than that with PSA or %fPSA. Although the present study is small and preliminary, these results suggest that the measurement of serum S2,3PSA using a magnetic microbead-based immunoassay may improve the accuracy of early detection of PCa and reduce unnecessary prostate biopsy. Copyright © 2014 Elsevier Inc. All rights reserved.

  16. An Improved Algorithm for Generating Database Transactions from Relational Algebra Specifications

    Directory of Open Access Journals (Sweden)

    Daniel J. Dougherty

    2010-03-01

    Full Text Available Alloy is a lightweight modeling formalism based on relational algebra. In prior work with Fisler, Giannakopoulos, Krishnamurthi, and Yoo, we have presented a tool, Alchemy, that compiles Alloy specifications into implementations that execute against persistent databases. The foundation of Alchemy is an algorithm for rewriting relational algebra formulas into code for database transactions. In this paper we report on recent progress in improving the robustness and efficiency of this transformation.

  17. Congener-specific carbon isotope analysis of technical PCN and PCB preparations using 2DGC-IRMS

    Energy Technology Data Exchange (ETDEWEB)

    Horii, Y.; Yamashita, N. [National Institute of Advanced Industrial Science and Technology (AIST). Tsukuba (Japan); Petrick, G. [Kiel Univ. (Germany). Inst. fuer Marineforschung; Katase, T. [Nihon Univ., Fujisawa (Japan). College of Bioresource Sciences; Gamo, T. [Tokyo Univ. (Japan). Ocean Research Institute

    2004-09-15

    Carbon isotope analysis is one of the most traditional approaches used in biogeochemical research for the last few decades. The isotopic composition of 13C/12C in bulk carbon has been measured in many kinds of environmental matrixes and supposed to be a useful indicator to understand biogeochemical circulation of carbon in ecosystems. With the recent advancements in instrumental analysis, compound-specific carbon isotope analysis (CSIA) is emerging as a hot issue in the research area of source determination of natural products. However, only limited investigations have been reported to date, regarding the CSIA of manmade chemicals such as polychlorinated biphenyls (PCBs). Although a traditional approaches such as fingerprinting, to determine sources of specific anthropogenic chemicals in environment has been in use for decades, those techniques are relatively more qualitative than quantitative; therefore, development of novel and reliable method is required to enable comprehensive understanding of sources and environmental destiny of man-made chemicals, especially those that are hazardous ones. In this study, we developed a new approach of CSIA using two-dimensional gas chromatograph (2DGC) with combustion chamber (C)/ isotope ratio mass spectrometer (IRMS) and applied for ''congener-specific'' carbon isotopic analysis of PCBs and polychlorinated naphthalenes (PCNs). We clarified the need to solve the co-elution of individual chlorobiphenyl and chloronaphthalene congeners and to decrease the blank for ''congener-specific'' CSIA.

  18. Advances in fuel pellet technology for improved performance at high burnup. Proceedings of a Technical Committee meeting

    International Nuclear Information System (INIS)

    1998-08-01

    The IAEA has recently completed two co-ordinated Research Programmes (CRPs) on The Development of Computer Models for Fuel Element Behaviour in Water Reactors, and on Fuel Modelling at Extended Burnup. Through these CRPs it became evident that there was a need to obtain data on fuel behaviour at high burnup. Data related o thermal behaviour, fission gas release and pellet to clad mechanical interaction were obtained and presented at the Technical Committee Meeting on Advances in Fuel Pellet Technology for Improved Performance at High Burnup which was recommended by the International Working Group on Fuel Performance and Technology (IWGFPT). The 34 papers from 10 countries are published in this proceedings and presented by a separate abstract. The papers were grouped in 6 sessions. First two sessions covered the fabrication of both UO 2 fuel and additives and MOX fuel. Sessions 3 and 4 covered the thermal behaviour of both types of fuel. The remaining two sessions dealt with fission gas release and the mechanical aspects of pellet to clad interaction

  19. Improving powerlifters’ technical preparedness at initial training stage using a device for remote control of competitive exercises technique

    Directory of Open Access Journals (Sweden)

    А. Власов

    2016-12-01

    Full Text Available The objective is to improve powerlifters’ technical preparedness at the initial training stage using a device for remote control of the competitive exercises technique. Materials and methods. The study relied on the following methods used: theoretical analysis and collation of data of scientific and methodological literature and internet; pedagogical observation; pedagogical experiment; methods of mathematical statistics. Results. We have designed an algorithmic structure for teaching squats with a barbell on shoulders in powerlifting and a device for remote control of the competitive exercises technique. We used the pedagogical experiment and pedagogical observation of the competitive activity to reveal reliable deviations (p > 0.05 in the number of mistakes made by the athletes of the reference and experimental groups during the competitive activity. The reference group powerlifters made the mistake “no straight angle between the knee and the hip joints when performing the third stage” twelve times, while the experimental group athletes — seven times. Conclusions. The results obtained allow to maintain that the experimental group athletes have more rationally mastered the competitive exercises technique and made fewer mistakes compared to the control group powerlifters. This confirms the effectiveness of the designed algorithmic structure for teaching squats with a barbell on shoulders.

  20. Domain-Specific and Domain-General Training to Improve Kindergarten Children’s Mathematics

    Directory of Open Access Journals (Sweden)

    Geetha B. Ramani

    2017-12-01

    Full Text Available Ensuring that kindergarten children have a solid foundation in early numerical knowledge is of critical importance for later mathematical achievement. In this study, we targeted improving the numerical knowledge of kindergarteners (n = 81 from primarily low-income backgrounds using two approaches: one targeting their conceptual knowledge, specifically, their understanding of numerical magnitudes; and the other targeting their underlying cognitive system, specifically, their working memory. Both interventions involved playing game-like activities on tablet computers over the course of several sessions. As predicted, both interventions improved children’s numerical magnitude knowledge as compared to a no-contact control group, suggesting that both domain-specific and domain-general interventions facilitate mathematical learning. Individual differences in effort during the working memory game, but not the number knowledge training game predicted children’s improvements in number line estimation. The results demonstrate the potential of using a rapidly growing technology in early childhood classrooms to promote young children’s numerical knowledge.

  1. Tentacle probe sandwich assay in porous polymer monolith improves specificity, sensitivity and kinetics.

    Science.gov (United States)

    Satterfield, Brent C; Caplan, Michael R; West, Jay A A

    2008-11-01

    Nucleic acid sandwich assays improve low-density array analysis through the addition of a capture probe and a specific label, increasing specificity and sensitivity. Here, we employ photo-initiated porous polymer monolith (PPM) as a high-surface area substrate for sandwich assay analysis. PPMs are shown to enhance extraction efficiency by 20-fold from 2 microl of sample. We further compare the performance of labeled linear probes, quantum dot labeled probes, molecular beacons (MBs) and tentacle probes (TPs). Each probe technology was compared and contrasted with traditional hybridization methods using labeled sample. All probes demonstrated similar sensitivity and greater specificity than traditional hybridization techniques. MBs and TPs were able to bypass a wash step due to their 'on-off' signaling mechanism. TPs demonstrated reaction kinetics 37.6 times faster than MBs, resulting in the fastest assay time of 5 min. Our data further indicate TPs had the most sensitive detection limit (1 x 10(4) improvement) among all tested probes in these experiments. By matching the enhanced extraction efficiencies of PPM with the selectivity of TPs, we have created a format for improved sandwich assays.

  2. High-intensity efforts in elite soccer matches and associated movement patterns, technical skills and tactical actions. Information for position-specific training drills.

    Science.gov (United States)

    Ade, Jack; Fitzpatrick, John; Bradley, Paul S

    2016-12-01

    This study aimed to translate movement patterns, technical skills and tactical actions associated with high-intensity efforts into metrics that could potentially be used to construct position-specific conditioning drills. A total of 20 individual English Premier League players' high-intensity running profiles were observed multiple times (n = 100) using a computerised tracking system. Data were analysed using a novel high-intensity movement programme across five positions (centre back [CB], full-back [FB], central midfielder [CM], wide midfielder [WM] and centre forward [CF]). High-intensity efforts in contact with the ball and the average speed of efforts were greater in WMs than CBs, CMs and CFs (effect sizes [ES]: 0.9-2.1, P high-intensity trends in and out of possession that could assist practitioners when devising position-specific drills.

  3. Improving Performance in Constructing specific Web Directory using Focused Crawler: An Experiment on Botany Domain

    Science.gov (United States)

    Khalilian, Madjid; Boroujeni, Farsad Zamani; Mustapha, Norwati

    Nowadays the growth of the web causes some difficulties to search and browse useful information especially in specific domains. However, some portion of the web remains largely underdeveloped, as shown in lack of high quality contents. An example is the botany specific web directory, in which lack of well-structured web directories have limited user's ability to browse required information. In this research we propose an improved framework for constructing a specific web directory. In this framework we use an anchor directory as a foundation for primary web directory. This web directory is completed by information which is gathered with automatic component and filtered by experts. We conduct an experiment for evaluating effectiveness, efficiency and satisfaction.

  4. Possibilities in improvement of the specific biodistribution by means of radiolabelled antibodies after complexation

    International Nuclear Information System (INIS)

    Heinrich, H.

    1990-01-01

    The applicability of labeled by different nuclides poly- or monoclonal antibodies in nuclear medicine diagnostics is restricted by incidental consequences. Overhigh background activities and/or high (additional) binding reactivities in the liver are troublesome. Hence we examined if the lokalizing biodistribution of labeled antibodies regarding the target organ can be improved by complexation with metal ions. The investigations were carried out with the pancreas of four Beagle dogs. Xenogenic polyclonal antibodies were refined by passing down the gammaglobulin fraction of rabbit serum a sephadex G 200 - column three times and hence radiolabeled by Na 131 I. Then the antibodies were injected i.p. either as complete molecules or as partially digested by pepsin fragments F(ab) 2 -fragments in order to avoid nonspecific Fc interactions. In preparing the i.p. injection another part of the antibody preparations both complete and fragments had been complexed with copper ions in an alkaline buffer giving a stable copper-protein-complex (Biuret-complex). Undergoing scanning and after killing the dogs the organ deposition of the radiolabel had been observed and noticed. The complexation with copper of radiolabeled antibodies improves strikingly the specific target organ uptake. Because of inflammatory and other incidental consequences the Fc-fragments should be removed by digestion with enzymes. Higher specific organ uptake should be obtainable if the poyclonal antibody fraction is more refined specifically by immunosorption with respect to its affinity to the specific antigenic structures. (orig.) [de

  5. Surface engineering of polyester-degrading enzymes to improve efficiency and tune specificity.

    Science.gov (United States)

    Biundo, Antonino; Ribitsch, Doris; Guebitz, Georg M

    2018-04-01

    Certain members of the carboxylesterase superfamily can act at the interface between water and water-insoluble substrates. However, nonnatural bulky polyesters usually are not efficiently hydrolyzed. In the recent years, the potential of enzyme engineering to improve hydrolysis of synthetic polyesters has been demonstrated. Regions on the enzyme surface have been modified by using site-directed mutagenesis in order to tune sorption processes through increased hydrophobicity of the enzyme surface. Such modifications can involve specific amino acid substitutions, addition of binding modules, or truncation of entire domains improving sorption properties and/or dynamics of the enzyme. In this review, we provide a comprehensive overview on different strategies developed in the recent years for enzyme surface engineering to improve the activity of polyester-hydrolyzing enzymes.

  6. Continuous Quality Improvement in a University Setting: The Case of the Department of Vocational and Technical Education at the University of Minnesota.

    Science.gov (United States)

    Copa, George H.

    1993-01-01

    Discusses the application of continuous quality improvement principles in the Department of Vocational and Technical Education at the University of Minnesota. Reviews the processes that the department incorporated to implement this program and lists future steps and categories of action. (Author)

  7. WT1-specific T cell receptor gene therapy: improving TCR function in transduced T cells.

    Science.gov (United States)

    Stauss, Hans J; Thomas, Sharyn; Cesco-Gaspere, Michela; Hart, Daniel P; Xue, Shao-An; Holler, Angelika; King, Judy; Wright, Graham; Perro, Mario; Pospori, Constantina; Morris, Emma

    2008-01-01

    Adoptive transfer of antigen-specific T lymphocytes is an attractive form of immunotherapy for haematological malignancies and cancer. The difficulty of isolating antigen-specific T lymphocytes for individual patients limits the more widespread use of adoptive T cell therapy. The demonstration that cloned T cell receptor (TCR) genes can be used to produce T lymphocyte populations of desired specificity offers new opportunities for antigen-specific T cell therapy. The first trial in humans demonstrated that TCR gene-modified T cells persisted for an extended time period and reduced tumor burden in some patients. The WT1 protein is an attractive target for immunotherapy of leukemia and solid cancer since elevated expression has been demonstrated in AML, CML, MDS and in breast, colon and ovarian cancer. In the past, we have isolated high avidity CTL specific for a WT1-derived peptide presented by HLA-A2 and cloned the TCR alpha and beta genes of a WT1-specific CTL line. The genes were inserted into retroviral vectors for transduction of human peripheral blood T lymphocytes of leukemia patients and normal donors. The treatment of leukemia-bearing NOD/SCID mice with T cells transduced with the WT1-specific TCR eliminated leukemia cells in the bone marrow of most mice, while treatment with T cells transduced with a TCR of irrelevant specificity did not diminish the leukemia burden. In order to improve the safety and efficacy of TCR gene therapy, we have developed lentiviral TCR gene transfer. In addition, we employed strategies to enhance TCR expression while avoiding TCR mis-pairing. It may be possible to generate dominant TCR constructs that can suppress the expression of the endogenous TCR on the surface of transduced T cells. The development of new TCR gene constructs holds great promise for the safe and effective delivery of TCR gene therapy for the treatment of malignancies.

  8. Intestine-specific overexpression of IL-10 improves survival in polymicrobial sepsis.

    Science.gov (United States)

    Rajan, Saju; Vyas, Dinesh; Clark, Andrew T; Woolsey, Cheryl A; Clark, Jessica A; Hotchkiss, Richard S; Buchman, Timothy G; Coopersmith, Craig M

    2008-04-01

    Targeted IL-10 therapy improves survival in preclinical models of critical illness, and intestine-specific IL-10 decreases inflammation in models of chronic Inflammatory disease. We therefore sought to determine whether intestine-specific overexpression of IL-10 would improve survival in sepsis. Transgenic mice that overexpress IL-10 in their gut epithelium (Fabpi-IL-10 mice) and wild-type (WT) littermates (n = 127) were subjected to cecal ligation and puncture with a 27-gauge needle. The 7-day survival rate was 45% in transgenic animals and 30% in WT animals (P < or = 0.05). Systemic levels of IL-10 were undetectable in both groups of animals under basal conditions and were elevated to a similar degree in septic animals regardless of whether they expressed the transgene. Local parameter of injury, including gut epithelial apoptosis, intestinal permeability, peritoneal lavage cytokines, and stimulated cytokines from intraepithelial lymphocytes, were similar between transgenic and WT mice. However, in stimulated splenocytes, proinflammatory cytokines monocyte chemoattractant protein 1 (189 +/- 43 vs. 40 +/- 8 pg/mL) and IL-6 (116 +/- 28 vs. 34 +/- 9 pg/mL) were lower in Fabpi-IL-10 mice than WT littermates despite the intestine-specific nature of the transgene (P < 0.05). Cytokine levels were similar in blood and bronchoalveolar lavage fluid between the 2 groups, as were circulating LPS levels. Transgenic mice also had lower white blood cell counts associated with lower absolute neutrophil counts (0.5 +/- 0.1 vs. 1.0 +/- 0.2 10(3)/mm3; P < 0.05). These results indicate that gut-specific overexpression of IL-10 improves survival in a murine model of sepsis, and interactions between the intestinal epithelium and the systemic immune system may play a role in conferring this survival advantage.

  9. [Impact of a targeted technical assistance to improve vaccine coverage in Cameroon, Côte d'Ivoire, and Mauritania in 2014].

    Science.gov (United States)

    Ahanhanzo, Y Glèlè; Palenfo, D; Saussier, C; Gbèdonou, P; Tonda, A; Da Silva, A; Aplogan, A

    2016-08-01

    Within the framework of its strategic goal of vaccine coverage (VC) improvement, GAVI, The Vaccine Alliance has entrusted the Agence de médecine préventive (agency for preventive medicine, AMP) with technical assistance services to Cameroon, Cote d'Ivoire (Ivory Coast), and Mauritania. This support was provided to selected priority districts (PDs) with the worst Penta3 coverage performances. In 2014, PDs benefited from technical and management capacities in vaccinology strengthening for district medical officers, supportive supervisions and technical assistance in health logistics, data management and quality. We analyzed the effects of the AMP technical assistance on the improvement of the cumulative Penta3 coverage, which is the key performance indicator of the expanded programme on immunization (EPI) performance. We compared Penta3 coverage between PDs and other non-priority districts (NPDs), Penta3 coverage evolution within each PD, and the distribution of PDs and NPDs according to Penta3 coverage category between January and December 2014. Technical assistance had a positive effect on the EPI performance. Indeed Penta3 coverage progression was higher in PDs than in NPDs throughout the period. Besides, between January and December 2014, the Penta3 VC increased in 70%, 100% and 86% of DPs in Cameroon, Côte d'Ivoire and Mauritania, respectively. Furthermore, the increase in the number of PDs with a Penta3 coverage over 80% was higher in DPs than in NPDs: 20% versus 8% for Cameroon, 58% versus 29% for Côte d'Ivoire and 17% versus 8% for Mauritania. Despite positive and encouraging results, this technical assistance service can be improved and efforts are needed to ensure that all health districts have a VC above 80% for all EPI vaccines. The current challenge is for African countries to mobilize resources for maintaining the knowledge and benefits and scaling such interventions in the public health area.

  10. Patient-specific reconstruction plates are the missing link in computer-assisted mandibular reconstruction: A showcase for technical description.

    Science.gov (United States)

    Cornelius, Carl-Peter; Smolka, Wenko; Giessler, Goetz A; Wilde, Frank; Probst, Florian A

    2015-06-01

    Preoperative planning of mandibular reconstruction has moved from mechanical simulation by dental model casts or stereolithographic models into an almost completely virtual environment. CAD/CAM applications allow a high level of accuracy by providing a custom template-assisted contouring approach for bone flaps. However, the clinical accuracy of CAD reconstruction is limited by the use of prebent reconstruction plates, an analogue step in an otherwise digital workstream. In this paper the integration of computerized, numerically-controlled (CNC) milled, patient-specific mandibular plates (PSMP) within the virtual workflow of computer-assisted mandibular free fibula flap reconstruction is illustrated in a clinical case. Intraoperatively, the bone segments as well as the plate arms showed a very good fit. Postoperative CT imaging demonstrated close approximation of the PSMP and fibular segments, and good alignment of native mandible and fibular segments and intersegmentally. Over a follow-up period of 12 months, there was an uneventful course of healing with good bony consolidation. The virtual design and automated fabrication of patient-specific mandibular reconstruction plates provide the missing link in the virtual workflow of computer-assisted mandibular free fibula flap reconstruction. Copyright © 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

  11. Technical note: Protozoa-specific antibodies raised in sheep plasma bind to their target protozoa in the rumen.

    Science.gov (United States)

    Williams, Y J; Rea, S M; Popovski, S; Skillman, L C; Wright, A-D G

    2014-12-01

    Binding of IgG antibodies to Entodinium spp. in the rumen of sheep (Ovis aries) was investigated by adding IgG, purified from plasma, directly into the rumen. Plasma IgG was sourced from sheep that had or had not been immunized with a vaccine containing whole fixed Entodinium spp. cells. Ruminal fluid was sampled approximately 2 h after each antibody dosing. Binding of protozoa by a specific antibody was detected using an indirect fluorescent antibody test. An antibody titer in the ruminal fluid was determined by ELISA, and the concentration of ruminal fluid ammonia-N and ruminal pH were also determined. Entodinium spp. and total protozoa from IgG-infused sheep were enumerated by microscopic counts. Two-hourly additions of IgG maintained a low antibody titer in the rumen for 12 h and the binding of the antibody to the rumen protozoa was demonstrated. Increased ammonia-N concentrations and altered ruminal fluid pH patterns indicated that additional fermentation of protein was occurring in the rumen after addition of IgG. No reduction in numbers of Entodinium spp. was observed (P>0.05). Although binding of antibodies to protozoa has been demonstrated in the rumen, it is unclear how much cell death occurred. On the balance of probability, it would appear that the antibody was degraded or partially degraded, and the impact of this on protozoal populations and the measurement of a specific titer is also unclear.

  12. Joint-Angle Specific Strength Adaptations Influence Improvements in Power in Highly Trained Athletes

    Directory of Open Access Journals (Sweden)

    Rhea Matthew R.

    2016-03-01

    Full Text Available Purpose. The purpose of this study was to examine the influence of training at different ranges of motion during the squat exercise on joint-angle specific strength adaptations. Methods. Twenty eight men were randomly assigned to one of three training groups, differing only in the depth of squats (quarter squat, half squat, and full squat performed in 16-week training intervention. Strength measures were conducted in the back squat pre-, mid-, and post-training at all three depths. Vertical jump and 40-yard sprint time were also measured. Results. Individuals in the quarter and full squat training groups improved significantly more at the specific depth at which they trained when compared to the other two groups (p < 0.05. Jump height and sprint speed improved in all groups (p < 0.05; however, the quarter squat had the greatest transfer to both outcomes. Conclusions. Consistently including quarter squats in workouts aimed at maximizing speed and jumping power can result in greater improvements.

  13. An Improved Abstract State Machine Based Choreography Specification and Execution Algorithm for Semantic Web Services

    Directory of Open Access Journals (Sweden)

    Shahin Mehdipour Ataee

    2018-01-01

    Full Text Available We identify significant weaknesses in the original Abstract State Machine (ASM based choreography algorithm of Web Service Modeling Ontology (WSMO, which make it impractical for use in semantic web service choreography engines. We present an improved algorithm which rectifies the weaknesses of the original algorithm, as well as a practical, fully functional choreography engine implementation in Flora-2 based on the improved algorithm. Our improvements to the choreography algorithm include (i the linking of the initial state of the ASM to the precondition of the goal, (ii the introduction of the concept of a final state in the execution of the ASM and its linking to the postcondition of the goal, and (iii modification to the execution of the ASM so that it stops when the final state condition is satisfied by the current configuration of the machine. Our choreography engine takes as input semantic web service specifications written in the Flora-2 dialect of F-logic. Furthermore, we prove the equivalence of ASMs (evolving algebras and evolving ontologies in the sense that one can simulate the other, a first in literature. Finally, we present a visual editor which facilitates the design and deployment of our F-logic based web service and goal specifications.

  14. Aerobic exercise prior to task-specific training to improve poststroke motor function: A case series.

    Science.gov (United States)

    Valkenborghs, S R; Visser, M M; Nilsson, M; Callister, R; van Vliet, P

    2018-02-13

    Aerobic exercise can improve upper limb motor function in both healthy and stroke populations. Research in animals after stroke has shown that aerobic exercise combined with forelimb motor training improved forelimb motor function more than aerobic exercise or motor training alone. There is a lack of knowledge about this combined intervention in humans after stroke. These 2 case reports describe the exploratory implementation of a combined aerobic exercise and task-specific training intervention to improve upper limb motor function in one person in subacute stroke recovery and one person in chronic stroke recovery. Case descriptions Subacute participant: 45-year-old female, 3 months after ischemic stroke resulting in left-sided hemiparesis affecting her non-dominant upper limb, with a baseline Action Research Arm Test (ARAT) score of 10/57 and Wolf Motor Function Test (WMFT) score of 39/75. Chronic participant: 69-year-old female, 14 years after ischemic stroke resulting in right-sided hemiparesis affecting her non-dominant upper limb, with a baseline ARAT score of 13/57 and WMFT score of 34/75. Intervention Participants performed 30 min of lower limb cycling immediately prior to 30 min of upper limb task-specific training. Sessions were undertaken 3 times a week for 8 weeks in a university rehabilitation laboratory. Results The combined intervention was feasible and perceived as acceptable and beneficial. Participants improved their upper limb motor function on the ARAT (subacute participant = 4 points; chronic participant = 2 points) and WMFT (subacute participant = 5 points; chronic participant = 3 points). Participants improved their aerobic fitness (subacute participant = +4.66 ml O 2 /kg/min; chronic participant = +7.34 ml O 2 /kg/min) and 6-minute walking distance (subacute participant = +50 m; chronic participant = +37 m). Discussion Combining aerobic exercise with task-specific training may be a worthwhile therapeutic approach to

  15. Technical documentation in support of the project-specific analysis for construction and operation of the National Ignition Facility

    Energy Technology Data Exchange (ETDEWEB)

    Lazaro, M.A.; Vinikour, W. [Argonne National Lab., IL (United States). Environmental Assessment Div.; Allison, T. [Argonne National Lab., IL (United States). Decision and Information Sciences Div.] [and others

    1996-09-01

    This document provides information that supports or supplements the data and impact analyses presented in the National Ignition Facility (NIF) Project-Specific Analysis (PSA). The purposes of NIF are to achieve fusion ignition in the laboratory for the first time with inertial confinement fusion (ICF) technology and to conduct high- energy-density experiments ins support of national security and civilian application. NIF is an important element in the DOE`s science-based SSM Program, a key mission of which is to ensure the reliability of the nation`s enduring stockpile of nuclear weapons. NIF would also advance the knowledge of basic and applied high-energy- density science and bring the nation a large step closer to developing fusion energy for civilian use. The NIF PSA includes evaluations of the potential environmental impacts of constructing and operating the facility at one of five candidate site and for two design options.

  16. Alterations in regulatory T cells induced by specific oligosaccharides improve vaccine responsiveness in mice.

    Directory of Open Access Journals (Sweden)

    Marcel A Schijf

    Full Text Available Prophylactic vaccinations are generally performed to protect naïve individuals with or without suppressed immune responsiveness. In a mouse model for Influenza vaccinations the specific alterations of CD4(+CD25(+Foxp3(+ regulatory T-cells (Tregs in the immune modulation induced by orally supplied oligosaccharides containing scGOS/lcFOS/pAOS was assessed. This dietary intervention increased vaccine specific DTH responses. In addition, a significant increased percentage of T-bet(+ (Th1 activated CD69(+CD4(+ T cells (p<0.001 and reduced percentage of Gata-3(+ (Th2 activated CD69(+CD4(+T cells (p<0.001 was detected in the mesenteric lymph nodes (MLN of mice receiving scGOS/lcFOS/pAOS compared to control mice. Although no difference in the number or percentage of Tregs (CD4(+Foxp3(+ could be determined after scGOS/lcFOS/pAOS intervention, the percentage of CXCR3 (+ /T-bet(+ (Th1-Tregs was significantly reduced (p<0.05 in mice receiving scGOS/lcFOS/pAOS as compared to mice receiving placebo diets. Moreover, although no absolute difference in suppressive capacity could be detected, an alteration in cytokine profile suggests a regulatory T cell shift towards a reducing Th1 suppression profile, supporting an improved vaccination response.These data are indicative for improved vaccine responsiveness due to reduced Th1 suppressive capacity in the Treg population of mice fed the oligosaccharide specific diet, showing compartmentalization within the Treg population. The modulation of Tregs to control immune responses provides an additional arm of intervention using alternative strategies possibly leading to the development of improved vaccines.

  17. MICB Allele Genotyping on Microarrays by Improving the Specificity of Extension Primers.

    Directory of Open Access Journals (Sweden)

    In-Cheol Baek

    Full Text Available Major histocompatibility complex (MHC class I chain-related gene B (MICB encodes a ligand for activating NKG2D that expressed in natural killer cells, γδ T cells, and αβ CD8+ T cells, which is associated with autoimmune diseases, cancer, and infectious diseases. Here, we have established a system for genotyping MICB alleles using allele-specific primer extension (ASPE on microarrays. Thirty-six high quality, allele-specific extension primers were evaluated using strict and reliable cut-off values using mean fluorescence intensity (MFI, whereby an MFI >30,000 represented a positive signal and an MFI <10,000 represented a negative signal. Eight allele-specific extension primers were found to be false positives, five of which were improved by adjusting their length, and three of which were optimized by refractory modification. The MICB alleles (*002:01, *003, *005:02/*010, *005:03, *008, *009N, *018, and *024 present in the quality control panel could be exactly defined by 22 allele-specific extension primers. MICB genotypes that were identified by ASPE on microarrays were in full concordance with those identified by PCR-sequence-based typing. In conclusion, we have developed a method for genotyping MICB alleles using ASPE on microarrays; which can be applicable for large-scale single nucleotide polymorphism typing studies of population and disease associations.

  18. Theta-burst microstimulation in the human entorhinal area improves memory specificity.

    Science.gov (United States)

    Titiz, Ali S; Hill, Michael R H; Mankin, Emily A; M Aghajan, Zahra; Eliashiv, Dawn; Tchemodanov, Natalia; Maoz, Uri; Stern, John; Tran, Michelle E; Schuette, Peter; Behnke, Eric; Suthana, Nanthia A; Fried, Itzhak

    2017-10-24

    The hippocampus is critical for episodic memory, and synaptic changes induced by long-term potentiation (LTP) are thought to underlie memory formation. In rodents, hippocampal LTP may be induced through electrical stimulation of the perforant path. To test whether similar techniques could improve episodic memory in humans, we implemented a microstimulation technique that allowed delivery of low-current electrical stimulation via 100 μm -diameter microelectrodes. As thirteen neurosurgical patients performed a person recognition task, microstimulation was applied in a theta-burst pattern, shown to optimally induce LTP. Microstimulation in the right entorhinal area during learning significantly improved subsequent memory specificity for novel portraits; participants were able both to recognize previously-viewed photos and reject similar lures. These results suggest that microstimulation with physiologic level currents-a radical departure from commonly used deep brain stimulation protocols-is sufficient to modulate human behavior and provides an avenue for refined interrogation of the circuits involved in human memory.

  19. Active training and driving-specific feedback improve older drivers' visual search prior to lane changes

    Directory of Open Access Journals (Sweden)

    Lavallière Martin

    2012-03-01

    Full Text Available Abstract Background Driving retraining classes may offer an opportunity to attenuate some effects of aging that may alter driving skills. Unfortunately, there is evidence that classroom programs (driving refresher courses do not improve the driving performance of older drivers. The aim of the current study was to evaluate if simulator training sessions with video-based feedback can modify visual search behaviors of older drivers while changing lanes in urban driving. Methods In order to evaluate the effectiveness of the video-based feedback training, 10 older drivers who received a driving refresher course and feedback about their driving performance were tested with an on-road standardized evaluation before and after participating to a simulator training program (Feedback group. Their results were compared to a Control group (12 older drivers who received the same refresher course and in-simulator active practice as the Feedback group without receiving driving-specific feedback. Results After attending the training program, the Control group showed no increase in the frequency of the visual inspection of three regions of interests (rear view and left side mirrors, and blind spot. In contrast, for the Feedback group, combining active training and driving-specific feedbacks increased the frequency of blind spot inspection by 100% (32.3 to 64.9% of verification before changing lanes. Conclusions These results suggest that simulator training combined with driving-specific feedbacks helped older drivers to improve their visual inspection strategies, and that in-simulator training transferred positively to on-road driving. In order to be effective, it is claimed that driving programs should include active practice sessions with driving-specific feedbacks. Simulators offer a unique environment for developing such programs adapted to older drivers' needs.

  20. Active training and driving-specific feedback improve older drivers' visual search prior to lane changes.

    Science.gov (United States)

    Lavallière, Martin; Simoneau, Martin; Tremblay, Mathieu; Laurendeau, Denis; Teasdale, Normand

    2012-03-02

    Driving retraining classes may offer an opportunity to attenuate some effects of aging that may alter driving skills. Unfortunately, there is evidence that classroom programs (driving refresher courses) do not improve the driving performance of older drivers. The aim of the current study was to evaluate if simulator training sessions with video-based feedback can modify visual search behaviors of older drivers while changing lanes in urban driving. In order to evaluate the effectiveness of the video-based feedback training, 10 older drivers who received a driving refresher course and feedback about their driving performance were tested with an on-road standardized evaluation before and after participating to a simulator training program (Feedback group). Their results were compared to a Control group (12 older drivers) who received the same refresher course and in-simulator active practice as the Feedback group without receiving driving-specific feedback. After attending the training program, the Control group showed no increase in the frequency of the visual inspection of three regions of interests (rear view and left side mirrors, and blind spot). In contrast, for the Feedback group, combining active training and driving-specific feedbacks increased the frequency of blind spot inspection by 100% (32.3 to 64.9% of verification before changing lanes). These results suggest that simulator training combined with driving-specific feedbacks helped older drivers to improve their visual inspection strategies, and that in-simulator training transferred positively to on-road driving. In order to be effective, it is claimed that driving programs should include active practice sessions with driving-specific feedbacks. Simulators offer a unique environment for developing such programs adapted to older drivers' needs.

  1. Using Surgeon-Specific Outcome Reports and Positive Deviance for Continuous Quality Improvement.

    Science.gov (United States)

    Ivanovic, Jelena; Anstee, Caitlin; Ramsay, Tim; Gilbert, Sebastien; Maziak, Donna E; Shamji, Farid M; Sundaresan, R Sudhir; Villeneuve, P James; Seely, Andrew J E

    2015-10-01

    Using the thoracic morbidity and mortality classification to document all postoperative adverse events between October 2012 and February 2014, we created surgeon-specific outcome reports (SSORs) to promote self-assessment and to implement a divisional continuous quality improvement (CQI) program, on the construct of positive deviance, to improve individual surgeon's clinical performance. Mixed-methods study within a division of six thoracic surgeons, involving (1) development of real-time, Web-based, risk-adjusted SSORs; (2) implementation of CQI seminars (n = 6; September 2013 to June 2014) for evaluation of results, collegial discussion on quality improvement based on identification of positive outliers, and selection of quality indicators for future discussion; and (3) in-person interviews to identify facilitators and barriers to using SSORs and CQI. Interview transcripts were analyzed using thematic analysis. Interviews revealed enthusiastic support for SSORs as a means to improve patient care through awareness of personal outcomes with blinded divisional comparison for similar operations and diseases, and apply the learning objectives to continuous professional development and maintenance of certification. Perceived limitations of SSORs included difficulty measuring surgeon expertise, limited understanding of risk adjustment, resistance to change, and belief that knowledge of sensitive data could lead to punitive actions. All surgeons believed CQI seminars led to collegial discussions, whereas perceived limitations included quorum participation and failing to circle back on actionable items. Real-time performance feedback using SSORs can motivate surgeons to improve their practice, and CQI seminars offer the opportunity to review and interpret results and address issues in a supportive environment. Whether SSORs and CQI can lead to improvements in rates of postoperative adverse events is a matter of ongoing research. Copyright © 2015 The Society of Thoracic

  2. Determination dimension and technical specification of the cylindrical pneumatics for the tote movement on multipurpose the gamma irradiator BATAN

    International Nuclear Information System (INIS)

    Muhammad Subhan; Ari Satmoko

    2016-01-01

    BATAN develops irradiator gamma category IV in cooperation with IZOTOP (Hungary). Transportation technology products that will be developed uses rail system to pool. Products that will be irradiated are put into tote then placed on the transportation rail, when tote has been in irradiated room tote enters into irradiated rack. The movement of the tote during on irradiated rack will be driven by the pneumatic system. Based on data from Isotop there are 14 cylindrical pneumatics that are in the irradiated room. Through the results analysis then used double acting cylinder type from the Festo pneumatics catalog. Through the results calculation that the force used on all types of cylinders for movement tote still much smaller than of force bent permitted. Beside that there are 4 group a pneumatic have common specifications they are group one cylindrical C1, C3, C12 and C14 they are group two cylindrical C2, C4, C11, and C13 they are group three cylindrical C7, C9, C15 and C17 they are group four cylindrical C10 and C17. (author)

  3. Mentors for Undergraduates in Technical Disciplines: A Collaborative Effort by Faculty, Student Development Professionals, and Alumni To Improve Undergraduate Retention and Success in Technical Majors.

    Science.gov (United States)

    Newton, Elizabeth; Wells-Glover, Linda

    1999-01-01

    Describes a program at Fontbonne College (Missouri) by the Department of Mathematics and Computer Science and Office of Multicultural Affairs that identified eight high-risk, first- and second-year students and matched them with four alumni mentors as part of a one-credit career management course. Evaluation showed improved academic performance…

  4. A kingdom-specific protein domain HMM library for improved annotation of fungal genomes

    Directory of Open Access Journals (Sweden)

    Oliver Stephen G

    2007-04-01

    Full Text Available Abstract Background Pfam is a general-purpose database of protein domain alignments and profile Hidden Markov Models (HMMs, which is very popular for the annotation of sequence data produced by genome sequencing projects. Pfam provides models that are often very general in terms of the taxa that they cover and it has previously been suggested that such general models may lack some of the specificity or selectivity that would be provided by kingdom-specific models. Results Here we present a general approach to create domain libraries of HMMs for sub-taxa of a kingdom. Taking fungal species as an example, we construct a domain library of HMMs (called Fungal Pfam or FPfam using sequences from 30 genomes, consisting of 24 species from the ascomycetes group and two basidiomycetes, Ustilago maydis, a fungal pathogen of maize, and the white rot fungus Phanerochaete chrysosporium. In addition, we include the Microsporidion Encephalitozoon cuniculi, an obligate intracellular parasite, and two non-fungal species, the oomycetes Phytophthora sojae and Phytophthora ramorum, both plant pathogens. We evaluate the performance in terms of coverage against the original 30 genomes used in training FPfam and against five more recently sequenced fungal genomes that can be considered as an independent test set. We show that kingdom-specific models such as FPfam can find instances of both novel and well characterized domains, increases overall coverage and detects more domains per sequence with typically higher bitscores than Pfam for the same domain families. An evaluation of the effect of changing E-values on the coverage shows that the performance of FPfam is consistent over the range of E-values applied. Conclusion Kingdom-specific models are shown to provide improved coverage. However, as the models become more specific, some sequences found by Pfam may be missed by the models in FPfam and some of the families represented in the test set are not present in FPfam

  5. Proceedings of the IAEA technical meeting in collaboration with NEA on specific applications of research reactors: provision of nuclear data

    International Nuclear Information System (INIS)

    Ridikas, D.; Bernard, D.; Cabellos, O.; Lee, Y.O.; Oberstedt, S.; Oshima, M.

    2010-07-01

    Research reactors (RRs) have played and continue to play a key role in the development of the peaceful uses of atomic energy. The main applications of most RRs continue to be radioisotope production, neutron beam applications, silicon doping and material irradiation for nuclear systems, as well as teaching and training for human resource development. What has been perceived as less important is the role of RRs to provide nuclear data, utilizing their inherent capability of integral experiments, benchmark, and validation analyses, particularly for the assessment of the safety margin and improvement of economic efficiency in the development and licensing of future nuclear power plants. In this respect, the previous International Conference on Nuclear Data for Science and Technology, held in Nice, France, from 22 to 27 April 2007, especially emphasized atomic and nuclear data needs for basic nuclear physics research, innovative power reactors and future fuel cycles (e.g., fast reactors, dedicated reactors for nuclear waste transmutation, accelerator driven systems, the Th-U fuel cycle, etc.), and the realization of fusion reactors (e.g., ITER). Other fields in which nuclear data are required relate to the testing of materials needed for such facilities, the evaluation of radioisotope production and their medical application, the simulation via computer software radiation of doses to patients and advanced cancer therapies, as well as the improvement of analytical techniques adopted for cultural heritage diagnostics and material composition analysis. RRs continue to occupy a visibly important place in these areas of study and application along with dedicated accelerator-based neutron sources. For example, an installation like the Lohengrin Fission Fragment Separator at Institute Laue-Langevin (ILL) in Grenoble, France, remains a unique place to study fission fragments and their properties as products of thermal neutron induced fission. Equally, the importance of

  6. Sphere-Enhanced Microwave Ablation (sMWA) Versus Bland Microwave Ablation (bMWA): Technical Parameters, Specific CT 3D Rendering and Histopathology

    Energy Technology Data Exchange (ETDEWEB)

    Gockner, T. L., E-mail: theresa.gockner@med.uni-heidelberg.de [University Hospital Heidelberg, Department of Diagnostic and Interventional Radiology (Germany); Zelzer, S., E-mail: s.zelzer@dkfz-heidelberg.de [German Cancer Research Center (dkfz), Medical and Biological Informatics (Germany); Mokry, T., E-mail: theresa.mokry@med.uni-heidelberg.de; Gnutzmann, D., E-mail: daniel.gnutzmann@med.uni-heidelberg.de; Bellemann, N., E-mail: nadine.bellemann@med.uni-heidelberg.de [University Hospital Heidelberg, Department of Diagnostic and Interventional Radiology (Germany); Mogler, C., E-mail: carolin.mogler@med.uni-heidelberg.de [University Hospital Heidelberg, Department of General Pathology (Germany); Beierfuß, A., E-mail: anja.beierfuss@ethianum.de; Köllensperger, E., E-mail: eva.koellensperger@ethianum.de; Germann, G., E-mail: guenter.germann@ethianum.de [Ethianum Heidelberg, Clinic for Plastic Reconstructive Surgery and Aesthetic Surgery (Germany); Radeleff, B. A., E-mail: boris.radeleff@med.uni-heidelberg.de; Stampfl, U., E-mail: ulrike.stampfl@med.uni-heidelberg.de; Kauczor, H. U., E-mail: hu.kauczor@med.uni-heidelberg.de [University Hospital Heidelberg, Department of Diagnostic and Interventional Radiology (Germany); Pereira, P. L., E-mail: philippe.pereira@slk-kliniken.de [SLK Kliniken Heilbronn GmbH, Clinic for Radiology, Minimally-invasive Therapies and Nuclear Medicine (Germany); Sommer, C. M., E-mail: christof.sommer@med.uni-heidelberg.de [University Hospital Heidelberg, Department of Diagnostic and Interventional Radiology (Germany)

    2015-04-15

    PurposeThis study was designed to compare technical parameters during ablation as well as CT 3D rendering and histopathology of the ablation zone between sphere-enhanced microwave ablation (sMWA) and bland microwave ablation (bMWA).MethodsIn six sheep-livers, 18 microwave ablations were performed with identical system presets (power output: 80 W, ablation time: 120 s). In three sheep, transarterial embolisation (TAE) was performed immediately before microwave ablation using spheres (diameter: 40 ± 10 μm) (sMWA). In the other three sheep, microwave ablation was performed without spheres embolisation (bMWA). Contrast-enhanced CT, sacrifice, and liver harvest followed immediately after microwave ablation. Study goals included technical parameters during ablation (resulting power output, ablation time), geometry of the ablation zone applying specific CT 3D rendering with a software prototype (short axis of the ablation zone, volume of the largest aligned ablation sphere within the ablation zone), and histopathology (hematoxylin-eosin, Masson Goldner and TUNEL).ResultsResulting power output/ablation times were 78.7 ± 1.0 W/120 ± 0.0 s for bMWA and 78.4 ± 1.0 W/120 ± 0.0 s for sMWA (n.s., respectively). Short axis/volume were 23.7 ± 3.7 mm/7.0 ± 2.4 cm{sup 3} for bMWA and 29.1 ± 3.4 mm/11.5 ± 3.9 cm{sup 3} for sMWA (P < 0.01, respectively). Histopathology confirmed the signs of coagulation necrosis as well as early and irreversible cell death for bMWA and sMWA. For sMWA, spheres were detected within, at the rim, and outside of the ablation zone without conspicuous features.ConclusionsSpecific CT 3D rendering identifies a larger ablation zone for sMWA compared with bMWA. The histopathological signs and the detectable amount of cell death are comparable for both groups. When comparing sMWA with bMWA, TAE has no effect on the technical parameters during ablation.

  7. Subject-specific knee joint geometry improves predictions of medial tibiofemoral contact forces

    Science.gov (United States)

    Gerus, Pauline; Sartori, Massimo; Besier, Thor F.; Fregly, Benjamin J.; Delp, Scott L.; Banks, Scott A.; Pandy, Marcus G.; D’Lima, Darryl D.; Lloyd, David G.

    2013-01-01

    Estimating tibiofemoral joint contact forces is important for understanding the initiation and progression of knee osteoarthritis. However, tibiofemoral contact force predictions are influenced by many factors including muscle forces and anatomical representations of the knee joint. This study aimed to investigate the influence of subject-specific geometry and knee joint kinematics on the prediction of tibiofemoral contact forces using a calibrated EMG-driven neuromusculoskeletal model of the knee. One participant fitted with an instrumented total knee replacement walked at a self-selected speed while medial and lateral tibiofemoral contact forces, ground reaction forces, whole-body kinematics, and lower-limb muscle activity were simultaneously measured. The combination of generic and subject-specific knee joint geometry and kinematics resulted in four different OpenSim models used to estimate muscle-tendon lengths and moment arms. The subject-specific geometric model was created from CT scans and the subject-specific knee joint kinematics representing the translation of the tibia relative to the femur was obtained from fluoroscopy. The EMG-driven model was calibrated using one walking trial, but with three different cost functions that tracked the knee flexion/extension moments with and without constraint over the estimated joint contact forces. The calibrated models then predicted the medial and lateral tibiofemoral contact forces for five other different walking trials. The use of subject-specific models with minimization of the peak tibiofemoral contact forces improved the accuracy of medial contact forces by 47% and lateral contact forces by 7%, respectively compared with the use of generic musculoskeletal model. PMID:24074941

  8. Towards the development of technical specifications for the production of lithium-lead alloys for the ITER HCLL TMB

    Energy Technology Data Exchange (ETDEWEB)

    Barrado, Ana Isabel, E-mail: anaisabel.barrado@ciemat.es [CIEMAT. Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas (Spain); Conde, Estefania; Fernandez, Marta [CIEMAT. Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas (Spain); Gomez-Salazar, Jose Maria [UCM. Dpto. De Ciencia de Materiales e Ingenieria Metalurgica (Spain); Quejido, Alberto; Quinones, Javier [CIEMAT. Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas (Spain)

    2012-08-15

    Highlights: Black-Right-Pointing-Pointer Pb-Li alloy plays a key role in the new commercial fusion reactors functionality. Black-Right-Pointing-Pointer It is important to have a complete characterization to define their physicochemical properties. Black-Right-Pointing-Pointer Methodology developed is a key tool that allows performing quality control procedures. Black-Right-Pointing-Pointer Determine concentrations of major and trace elements, which can be found in Pb-Li alloy. - Abstract: The ITER and DEMO projects are developing new Test Blanket Modules (TBM), where the Pb-Li alloy plays a key role in the new commercial fusion reactors functionality. The Breeding Blanket (BB) has to perform several functions which are essential for the reactor operation. The HCLL TBM is one of the Breeding Blanket concepts to be tested in ITER. It is cooled by He and uses the eutectic liquid metal LLE (Lithium-Lead Eutectic) as breeder material (enriched at 90% in {sup 6}Li). Pb-Li eutectic alloy has no known uses outside of fusion technology, so the available databases of this material are currently incomplete. It is very important, within the material specifications, to have a complete characterization in order to define their chemical and physical properties, because any variation in the alloy composition has significant consequences in their behaviour, and therefore in their regenerative function inside the blanket. The chemical characterization methodology developed and presented in this paper (useful for both Pb-Li alloys as any Pb alloy) is a key tool that allows performing standard quality control procedures for base material and/or monitoring the alloy during the reactor operation. This report provides a procedure to perform a wide material chemical characterization, assessing the concentrations of major elements, as well as a review of trace level elements that can be found both in the eutectic alloy and in starting materials. In this determination plays an important

  9. Precise Genome Modification via Sequence-Specific Nucleases-Mediated Gene Targeting for Crop Improvement.

    Science.gov (United States)

    Sun, Yongwei; Li, Jingying; Xia, Lanqin

    2016-01-01

    Genome editing technologies enable precise modifications of DNA sequences in vivo and offer a great promise for harnessing plant genes in crop improvement. The precise manipulation of plant genomes relies on the induction of DNA double-strand breaks by sequence-specific nucleases (SSNs) to initiate DNA repair reactions that are based on either non-homologous end joining (NHEJ) or homology-directed repair (HDR). While complete knock-outs and loss-of-function mutations generated by NHEJ are very valuable in defining gene functions, their applications in crop improvement are somewhat limited because many agriculturally important traits are conferred by random point mutations or indels at specific loci in either the genes' encoding or promoter regions. Therefore, genome modification through SSNs-mediated HDR for gene targeting (GT) that enables either gene replacement or knock-in will provide an unprecedented ability to facilitate plant breeding by allowing introduction of precise point mutations and new gene functions, or integration of foreign genes at specific and desired "safe" harbor in a predefined manner. The emergence of three programmable SSNs, such as zinc finger nucleases, transcriptional activator-like effector nucleases, and the clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 (Cas9) systems has revolutionized genome modification in plants in a more controlled manner. However, while targeted mutagenesis is becoming routine in plants, the potential of GT technology has not been well realized for traits improvement in crops, mainly due to the fact that NHEJ predominates DNA repair process in somatic cells and competes with the HDR pathway, and thus HDR-mediated GT is a relative rare event in plants. Here, we review recent research findings mainly focusing on development and applications of precise GT in plants using three SSNs systems described above, and the potential mechanisms underlying HDR events in plant

  10. Precise Genome Modification via Sequence-Specific Nucleases-Mediated Gene Targeting for Crop Improvement

    Science.gov (United States)

    Sun, Yongwei; Li, Jingying; Xia, Lanqin

    2016-01-01

    Genome editing technologies enable precise modifications of DNA sequences in vivo and offer a great promise for harnessing plant genes in crop improvement. The precise manipulation of plant genomes relies on the induction of DNA double-strand breaks by sequence-specific nucleases (SSNs) to initiate DNA repair reactions that are based on either non-homologous end joining (NHEJ) or homology-directed repair (HDR). While complete knock-outs and loss-of-function mutations generated by NHEJ are very valuable in defining gene functions, their applications in crop improvement are somewhat limited because many agriculturally important traits are conferred by random point mutations or indels at specific loci in either the genes’ encoding or promoter regions. Therefore, genome modification through SSNs-mediated HDR for gene targeting (GT) that enables either gene replacement or knock-in will provide an unprecedented ability to facilitate plant breeding by allowing introduction of precise point mutations and new gene functions, or integration of foreign genes at specific and desired “safe” harbor in a predefined manner. The emergence of three programmable SSNs, such as zinc finger nucleases, transcriptional activator-like effector nucleases, and the clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 (Cas9) systems has revolutionized genome modification in plants in a more controlled manner. However, while targeted mutagenesis is becoming routine in plants, the potential of GT technology has not been well realized for traits improvement in crops, mainly due to the fact that NHEJ predominates DNA repair process in somatic cells and competes with the HDR pathway, and thus HDR-mediated GT is a relative rare event in plants. Here, we review recent research findings mainly focusing on development and applications of precise GT in plants using three SSNs systems described above, and the potential mechanisms underlying HDR events in

  11. Precise genome modification via sequence-specific nucleases-mediated gene targeting for crop improvement

    Directory of Open Access Journals (Sweden)

    Yongwei Sun

    2016-12-01

    Full Text Available Genome editing technologies enable precise modifications of DNA sequences in vivo and offer a great promise for harnessing plant genes in crop improvement. The precise manipulation of plant genomes relies on the induction of DNA double-strand breaks (DSBs by sequence-specific nucleases (SSNs to initiate DNA repair reactions that are based on either non-homologous end joining (NHEJ or homology-directed repair (HDR. While complete knock-outs and loss-of-function mutations generated by NHEJ are very valuable in defining gene functions, their applications in crop improvement are somewhat limited because many agriculturally important traits are conferred by random point mutations or indels at specific loci in either the genes’ encoding or promoter regions. Therefore, genome modification through SSNs-mediated HDR for gene targeting (GT that enables either gene replacement or knock-in will provide an unprecedented ability to facilitate plant breeding by allowing introduction of precise point mutations and new gene functions, or integration of foreign genes at specific and desired ‘safe’ harbor in a predefined manner. The emergence of three programmable SSNs such as zinc finger nucleases (ZFNs, transcriptional activator-like effector nucleases (TALENs, and the clustered regularly interspaced short palindromic repeat (CRISPR/CRISPR-associated protein 9 (Cas9 systems has revolutionized genome modification in plants in a more controlled manner. However, while targeted mutagenesis is becoming routine in plants, the potential of GT technology has not been well realized for traits improvement in crops, mainly due to the fact that NHEJ predominates DNA repair process in somatic cells and competes with the HDR pathway, and thus HDR-mediated GT is a relative rare event in plants. Here, we review recent research findings mainly focusing on development and applications of precise GT in plants using three SSNs systems described above, and the potential

  12. Enterocyte-specific epidermal growth factor prevents barrier dysfunction and improves mortality in murine peritonitis.

    Science.gov (United States)

    Clark, Jessica A; Gan, Heng; Samocha, Alexandr J; Fox, Amy C; Buchman, Timothy G; Coopersmith, Craig M

    2009-09-01

    Systemic administration of epidermal growth factor (EGF) decreases mortality in a murine model of septic peritonitis. Although EGF can have direct healing effects on the intestinal mucosa, it is unknown whether the benefits of systemic EGF in peritonitis are mediated through the intestine. Here, we demonstrate that enterocyte-specific overexpression of EGF is sufficient to prevent intestinal barrier dysfunction and improve survival in peritonitis. Transgenic FVB/N mice that overexpress EGF exclusively in enterocytes (IFABP-EGF) and wild-type (WT) mice were subjected to either sham laparotomy or cecal ligation and puncture (CLP). Intestinal permeability, expression of the tight junction proteins claudins-1, -2, -3, -4, -5, -7, and -8, occludin, and zonula occludens-1; villus length; intestinal epithelial proliferation; and epithelial apoptosis were evaluated. A separate cohort of mice was followed for survival. Peritonitis induced a threefold increase in intestinal permeability in WT mice. This was associated with increased claudin-2 expression and a change in subcellular localization. Permeability decreased to basal levels in IFABP-EGF septic mice, and claudin-2 expression and localization were similar to those of sham animals. Claudin-4 expression was decreased following CLP but was not different between WT septic mice and IFABP-EGF septic mice. Peritonitis-induced decreases in villus length and proliferation and increases in apoptosis seen in WT septic mice did not occur in IFABP-EGF septic mice. IFABP-EGF mice had improved 7-day mortality compared with WT septic mice (6% vs. 64%). Since enterocyte-specific overexpression of EGF is sufficient to prevent peritonitis-induced intestinal barrier dysfunction and confers a survival advantage, the protective effects of systemic EGF in septic peritonitis appear to be mediated in an intestine-specific fashion.

  13. Improvement of Prostate Cancer Diagnosis by Detecting PSA Glycosylation-Specific Changes.

    Science.gov (United States)

    Llop, Esther; Ferrer-Batallé, Montserrat; Barrabés, Sílvia; Guerrero, Pedro Enrique; Ramírez, Manel; Saldova, Radka; Rudd, Pauline M; Aleixandre, Rosa N; Comet, Josep; de Llorens, Rafael; Peracaula, Rosa

    2016-01-01

    New markers based on PSA isoforms have recently been developed to improve prostate cancer (PCa) diagnosis. However, novel approaches are still required to differentiate aggressive from non-aggressive PCa to improve decision making for patients. PSA glycoforms have been shown to be differentially expressed in PCa. In particular, changes in the extent of core fucosylation and sialylation of PSA N-glycans in PCa patients compared to healthy controls or BPH patients have been reported. The objective of this study was to determine these specific glycan structures in serum PSA to analyze their potential value as markers for discriminating between BPH and PCa of different aggressiveness. In the present work, we have established two methodologies to analyze the core fucosylation and the sialic acid linkage of PSA N-glycans in serum samples from BPH (29) and PCa (44) patients with different degrees of aggressiveness. We detected a significant decrease in the core fucose and an increase in the α2,3-sialic acid percentage of PSA in high-risk PCa that differentiated BPH and low-risk PCa from high-risk PCa patients. In particular, a cut-off value of 0.86 of the PSA core fucose ratio, could distinguish high-risk PCa patients from BPH with 90% sensitivity and 95% specificity, with an AUC of 0.94. In the case of the α2,3-sialic acid percentage of PSA, the cut-off value of 30% discriminated between high-risk PCa and the group of BPH, low-, and intermediate-risk PCa with a sensitivity and specificity of 85.7% and 95.5%, respectively, with an AUC of 0.97. The latter marker exhibited high performance in differentiating between aggressive and non-aggressive PCa and has the potential for translational application in the clinic.

  14. Does service integration improve technical quality of care in low-resource settings? An evaluation of a model integrating HIV care into family planning services in Kenya.

    Science.gov (United States)

    Mutemwa, Richard; Mayhew, Susannah H; Warren, Charlotte E; Abuya, Timothy; Ndwiga, Charity; Kivunaga, Jackline

    2017-11-01

    The aim of this study was to investigate association between HIV and family planning integration and technical quality of care. The study focused on technical quality of client-provider consultation sessions. The cross-sectional study observed 366 client-provider consultation sessions and interviewed 37 health care providers in 12 public health facilities in Kenya. Multilevel random intercept and linear regression models were fitted to the matched data to investigate relationships between service integration and technical quality of care as well as associations between facility-level structural and provider factors and technical quality of care. A sensitivity analysis was performed to test for hidden bias. After adjusting for facility-level structural factors, HIV/family planning integration was found to have significant positive effect on technical quality of the consultation session, with average treatment effect 0.44 (95% CI: 0.63-0.82). Three of the 12 structural factors were significantly positively associated with technical quality of consultation session including: availability of family planning commodities (9.64; 95% CI: 5.07-14.21), adequate infrastructure (5.29; 95% CI: 2.89-7.69) and reagents (1.48; 95% CI: 1.02-1.93). Three of the nine provider factors were significantly positively associated with technical quality of consultation session: appropriate provider clinical knowledge (3.14; 95% CI: 1.92-4.36), job satisfaction (2.02; 95% CI: 1.21-2.83) and supervision (1.01; 95% CI: 0.35-1.68), while workload (-0.88; 95% CI: -1.75 to - 0.01) was negatively associated. Technical quality of the client-provider consultation session was also determined by duration of the consultation and type of clinic visit and appeared to depend on whether the clinic visit occurred early or later in the week. Integration of HIV care into family planning services can improve the technical quality of client-provider consultation sessions as measured by both health facility

  15. Species-Specific Chromosome Engineering Greatly Improves Fully Human Polyclonal Antibody Production Profile in Cattle.

    Science.gov (United States)

    Matsushita, Hiroaki; Sano, Akiko; Wu, Hua; Wang, Zhongde; Jiao, Jin-An; Kasinathan, Poothappillai; Sullivan, Eddie J; Kuroiwa, Yoshimi

    2015-01-01

    Large-scale production of fully human IgG (hIgG) or human polyclonal antibodies (hpAbs) by transgenic animals could be useful for human therapy. However, production level of hpAbs in transgenic animals is generally very low, probably due to the fact that evolutionarily unique interspecies-incompatible genomic sequences between human and non-human host species may impede high production of fully hIgG in the non-human environment. To address this issue, we performed species-specific human artificial chromosome (HAC) engineering and tested these engineered HAC in cattle. Our previous study has demonstrated that site-specific genomic chimerization of pre-B cell receptor/B cell receptor (pre-BCR/BCR) components on HAC vectors significantly improves human IgG expression in cattle where the endogenous bovine immunoglobulin genes were knocked out. In this report, hIgG1 class switch regulatory elements were subjected to site-specific genomic chimerization on HAC vectors to further enhance hIgG expression and improve hIgG subclass distribution in cattle. These species-specific modifications in a chromosome scale resulted in much higher production levels of fully hIgG of up to 15 g/L in sera or plasma, the highest ever reported for a transgenic animal system. Transchromosomic (Tc) cattle containing engineered HAC vectors generated hpAbs with high titers against human-origin antigens following immunization. This study clearly demonstrates that species-specific sequence differences in pre-BCR/BCR components and IgG1 class switch regulatory elements between human and bovine are indeed functionally distinct across the two species, and therefore, are responsible for low production of fully hIgG in our early versions of Tc cattle. The high production levels of fully hIgG with hIgG1 subclass dominancy in a large farm animal species achieved here is an important milestone towards broad therapeutic applications of hpAbs.

  16. Redundancy, resilience and host specificity of the ruminal microbiota: Implications for engineering improved ruminal fermentations

    Directory of Open Access Journals (Sweden)

    Paul James Weimer

    2015-04-01

    Full Text Available The ruminal microbial community is remarkably diverse, containing hundreds of different bacterial and archaeal species, plus many species of fungi and protozoa. Molecular studies have identified a core microbiome dominated by phyla Firmicutes and Bacteroidetes, but also containing many other taxa. The rumen provides an ideal laboratory for studies on microbial ecology and the demonstration of ecological principles. In particular, the microbial community demonstrates both redundancy (overlap of function among multiple species and resilience (resistance to, and capacity to recover from, perturbation. These twin properties provide remarkable stability that maintains digestive function for the host across a range of feeding and management conditions, but they also provide a challenge to engineering the rumen for improved function (e.g., improved fiber utilization or decreased methane production. Direct ruminal dosing or feeding of probiotic strains often fails to establish the added strains, due to intensive competition and amensalism from the indigenous residents that are well-adapted to the historical conditions within each rumen. Known exceptions include introduced strains that can fill otherwise unoccupied niches, as in the case of specialist bacteria that degrade phytotoxins such as mimosine or fluoroacetate. An additional complicating factor in manipulating the ruminal fermentation is the individuality or host specificity of the microbiota, in which individual animals contain a particular community whose species composition is capable of reconstituting itself, even following a near-total exchange of ruminal contents from another herd mate maintained on the same diet. Elucidation of the interactions between the microbial community and the individual host that establish and maintain this specificity may provide insights into why individual hosts vary in production metrics (e.g., feed efficiency or milk fat synthesis, and how to improve herd

  17. Severe pulmonary hypertension associated with COPD: hemodynamic improvement with specific therapy.

    Science.gov (United States)

    Girard, Anne; Jouneau, Stephane; Chabanne, Céline; Khouatra, Chahéra; Lannes, Morgane; Traclet, Julie; Turquier, Ségolène; Delaval, P; Cordier, J-F; Cottin, Vincent

    2015-01-01

    There is no recommendation for treating pulmonary hypertension (PH) when associated with chronic obstructive pulmonary disease (COPD). To evaluate the effect of PH-specific therapy in patients with COPD. All successive patients with severe PH [mean pulmonary arterial pressure (mPAP) ≥35 mm Hg] and COPD, who received specific PH medication and who underwent right heart catheterization at baseline and after 3-12 months of treatment, were analyzed from a prospective database. Twenty-six patients were included with a median follow-up of 14 months. Mean forced expiratory volume in 1 s was 57 ± 20% of predicted, and mean forced expiratory volume in 1 s/forced vital capacity was 47 ± 12%. Dyspnea was New York Health Association classification stage (NYHA) II in 15%, NYHA III in 81% and NYHA IV in 4%. First-line treatments were endothelin receptor antagonists in 11 patients, phosphodiesterase-5 inhibitors in 11 patients, calcium blocker in 1 patient, combination therapy in 3 patients including 2 with a prostanoid. After 6 ± 3 months, pulmonary vascular resistance decreased from 8.5 ± 3 to 6.6 ± 2 Wood units (p arterial oxygen saturation after 3-12 months of treatment. Specific PH medications may improve hemodynamic parameters in COPD patients with severe PH. Appropriate prospective randomized studies are needed to evaluate the potential long-term clinical benefit of treatment. © 2015 S. Karger AG, Basel.

  18. Affinity maturation generates greatly improved xyloglucan-specific carbohydrate binding modules

    Directory of Open Access Journals (Sweden)

    Cicortas Gunnarsson Lavinia

    2009-10-01

    Full Text Available Abstract Background Molecular evolution of carbohydrate binding modules (CBM is a new approach for the generation of glycan-specific molecular probes. To date, the possibility of performing affinity maturation on CBM has not been investigated. In this study we show that binding characteristics such as affinity can be improved for CBM generated from the CBM4-2 scaffold by using random mutagenesis in combination with phage display technology. Results Two modified proteins with greatly improved affinity for xyloglucan, a key polysaccharide abundant in the plant kingdom crucial for providing plant support, were generated. Both improved modules differ from other existing xyloglucan probes by binding to galactose-decorated subunits of xyloglucan. The usefulness of the evolved binders was verified by staining of plant sections, where they performed better than the xyloglucan-binding module from which they had been derived. They discriminated non-fucosylated from fucosylated xyloglucan as shown by their ability to stain only the endosperm, rich in non-fucosylated xyloglucan, but not the integument rich in fucosylated xyloglucan, on tamarind seed sections. Conclusion We conclude that affinity maturation of CBM selected from molecular libraries based on the CBM4-2 scaffold is possible and has the potential to generate new analytical tools for detection of plant carbohydrates.

  19. Crowd-sourced assessment of technical skills: an opportunity for improvement in the assessment of laparoscopic surgical skills.

    Science.gov (United States)

    Deal, Shanley B; Lendvay, Thomas S; Haque, Mohamad I; Brand, Timothy; Comstock, Bryan; Warren, Justin; Alseidi, Adnan

    2016-02-01

    Objective, unbiased assessment of surgical skills remains a challenge in surgical education. We sought to evaluate the feasibility and reliability of Crowd-Sourced Assessment of Technical Skills. Seven volunteer general surgery interns were given time for training and then testing, on laparoscopic peg transfer, precision cutting, and intracorporeal knot-tying. Six faculty experts (FEs) and 203 Amazon.com Mechanical Turk crowd workers (CWs) evaluated 21 deidentified video clips using the Global Objective Assessment of Laparoscopic Skills validated rating instrument. Within 19 hours and 15 minutes we received 662 eligible ratings from 203 CWs and 126 ratings from 6 FEs over 10 days. FE video ratings were of borderline internal consistency (Krippendorff's alpha = .55). FE ratings were highly correlated with CW ratings (Pearson's correlation coefficient = .78, P Technical Skills as a reliable, basic tool to standardize the evaluation of technical skills in general surgery. Copyright © 2016 Elsevier Inc. All rights reserved.

  20. Improving of technical characteristics of launch vehicles with liquid rocket engines using active onboard de-orbiting systems

    Science.gov (United States)

    Trushlyakov, V.; Shatrov, Ya.

    2017-09-01

    In this paper, the analysis of technical requirements (TR) for the development of modern space launch vehicles (LV) with main liquid rocket engines (LRE) is fulfilled in relation to the anthropogenic impact decreasing. Factual technical characteristics on the example of a promising type of rocket ;Soyuz-2.1.v.; are analyzed. Meeting the TR in relation to anthropogenic impact decrease based on the conventional design approach and the content of the onboard system does not prove to be efficient and leads to depreciation of the initial technical characteristics obtained at the first design stage if these requirements are not included. In this concern, it is shown that the implementation of additional active onboard de-orbiting system (AODS) of worked-off stages (WS) into the onboard LV stages systems allows to meet the TR related to the LV environmental characteristics, including fire-explosion safety. In some cases, the orbital payload mass increases.

  1. Improvement of western blot test specificity for detecting equine serum antibodies to Sarcocystis neurona.

    Science.gov (United States)

    Rossano, M G; Mansfield, L S; Kaneene, J B; Murphy, A J; Brown, C M; Schott, H C; Fox, J C

    2000-01-01

    Equine protozoal myeloencephalitis (EPM) is a neurological disease of horses and ponies caused by the apicomplexan protozoan parasite Sarcocystis neurona. The purposes of this study were to develop the most stringent criteria possible for a positive test result, to estimate the sensitivity and specificity of the EPM Western blot antibody test, and to assess the ability of bovine antibodies to Sarcocystis cruzi to act as a blocking agent to minimize false-positive results in the western blot test for S. neurona. Sarcocystis neurona merozoites harvested from equine dermal cell culture were heat denatured, and the proteins were separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis in a 12-20% linear gradient gel. Separated proteins were electrophoretically transferred to polyvinylidene fluoride membranes and blocked in 1% bovine serum albumin and 0.5% Tween-Tris-buffered saline. Serum samples from 6 horses with S. neurona infections (confirmed by culture from neural tissue) and 57 horses without infections (horses from the Eastern Hemisphere, where S. neurona does not exist) were tested by Western blot. Horses from both groups had reactivity to the 62-, 30-, 16-, 13-, 11-, 10.5-, and 10-kD bands. Testing was repeated with another step. Blots were treated with bovine S. cruzi antibodies prior to loading the equine samples. After this modification of the Western blot test, positive infection status was significantly associated with reactivity to the 30- and 16-kD bands (Pblot had a sample sensitivity of 100% and sample specificity of 98%. It is concluded that the specificity of the Western blot test is improved by blocking proteins not specific to S. neurona and using reactivity to the 30- and 16-kD bands as the criterion for a positive test.

  2. Specific improvement measures to reduce complications and mortality after urgent surgery in complicated abdominal wall hernia.

    Science.gov (United States)

    Martínez-Serrano, M A; Pereira, J A; Sancho, J; Argudo, N; López-Cano, M; Grande, L

    2012-04-01

    Morbidity and mortality are increased after urgent surgery for complicated abdominal wall hernia. We analysed prospectively early morbidity and mortality after implementing specific management measures in patients undergoing urgent hernia repair. The study population included 244 patients with complicated abdominal wall hernia requiring surgical repair on an emergency basis over 1-year period. Patients were managed according to a protocol that included specific actions to be implemented in the pre-, intra- and postoperative periods. Outcomes of these patients were compared with those of 402 undergoing similar operations before development of the protocol. Patients in whom acute complication was the first hernia symptom had higher mortality (7.2% vs 2.5%; P = 0.07) and were consulted later than 24 h (49.4% vs 36%; P = 0.044). Patients consulting later than 24 h had higher mortality (8.1% vs 1.4%, P = 0.017). Femoral hernias exhibited specific characteristics and were associated with higher mortality (13% vs 1.6%; P = 0.001). Overall, both groups had similar mortality (4.5% vs 4.1%; P = 0.8); complications (38.8% vs 37.7%; P = 0.2), and bowel resection rates (12.2% vs 11.5%; P = 0.8). Excluding the group of femoral hernias, the measures achieved a lower rate of severe complications (21.2% vs 10.3%; P = 0.04) and a decrease in mortality (2.9% vs 0.6%; P = 0.05) after bowel resection. Specific measures for improvement of management and prevention of complications and mortality were effective in patients without femoral hernia. To reduce mortality, the best applicable measure is early detection and to prioritize the scheduled operation of femoral hernias and those affecting high risk patients. The implementation of preventive and educational programs in high risk patients is essential.

  3. A Diabetes-specific Oral Nutritional Supplement Improves Glycaemic Control in Type 2 Diabetes Patients.

    Science.gov (United States)

    Mayr, P; Kuhn, K S; Klein, P; Stover, J F; Pestana, E A

    2016-07-01

    Reducing the intake of low molecular weight carbohydrates with artificial nutrition may lower glycaemic response in patients with diabetes. We evaluated effects of a diabetes-specific carbohydrate modified oral nutritional supplement (ONS) during 12 weeks administration in 40 elderly type 2 normal weight patients with diabetes with previous involuntary weight loss. Prospective, randomised, double-blind, controlled trial. Patients ingested 2×200 ml/day diabetes-specific or isocaloric standard ONS (control) in addition to their regular diet. Parameters of glucose and lipid metabolism, functional and nutritional status were assessed at baseline, weeks 6 and 12. Postprandial glucose incremental area under the curve (iAUC0-240 min) was comparable between treatment groups on day 1 (467.9±268.4 vs. 505.1±206.1 mmol/l*min, n.s. - arithmetic means±standard deviation) and was significantly lower with the diabetes-specific ONS vs. controls in weeks 6 and 12 (355.2±115.8 vs. 634.9±205.9 and 364.9±153.1 vs. 743.4±202.7; both Pnutritional and performance status. Body weight and body mass index (BMI) increased significantly over time in both groups. Administration of a diabetes-specific ONS for 12 weeks reduced postprandial glycaemia after ingestion of the study treatment and improved long-term glycaemic control in elderly patients with type 2 diabetes and involuntary weight loss, thereby reducing their risk for diabetes-associated long-term complications. © Georg Thieme Verlag KG Stuttgart · New York.

  4. The challenging ultrasound diagnosis of perforated appendicitis in children: constellations of sonographic findings improve specificity.

    Science.gov (United States)

    Tulin-Silver, Sheryl; Babb, James; Pinkney, Lynne; Strubel, Naomi; Lala, Shailee; Milla, Sarah S; Tomita, Sandra; Fefferman, Nancy R

    2015-06-01

    Rapid and accurate diagnosis of appendicitis, particularly with respect to the presence or absence of perforation, is essential in guiding appropriate management. Although many studies have explored sonographic findings associated with acute appendicitis, few investigations discuss specific signs that can reliably differentiate perforated appendicitis from acute appendicitis prior to abscess formation. The purpose of our study was to identify sonographic findings that improve the specificity of US in the diagnosis of perforated appendicitis. Our assessment of hepatic periportal echogenicity, detailed analysis of intraperitoneal fluid, and formulation of select constellations of sonographic findings expands upon the literature addressing this important diagnostic challenge. We retrospectively reviewed 116 abdominal US examinations for evaluation of abdominal pain in children ages 2 to 18 years from January 2008 to September 2011 at a university hospital pediatric radiology department. The study group consisted of surgical and pathology proven acute appendicitis (n = 51) and perforated appendicitis (n = 22) US exams. US exams without a sonographic diagnosis of appendicitis (n = 43) confirmed by follow-up verbal communication were included in the study population as the control group. After de-identification, the US exams were independently reviewed on a PACS workstation by four pediatric radiologists blinded to diagnosis and all clinical information. We recorded the presence of normal or abnormal appendix, appendicolith, appendiceal wall vascularity, thick-walled bowel, dilated bowel, right lower quadrant (RLQ) echogenic fat, increased hepatic periportal echogenicity, bladder debris and abscess or loculated fluid. We also recorded the characteristics of intraperitoneal fluid, indicating the relative quantity (number of abdominal regions) and quality of the fluid (simple fluid or complex fluid). We used logistic regression for correlated data to evaluate

  5. Improving Forsyth Technical Community College's Ability to Develop and Maintain Partnerships: Leveraging Technology to Develop Partnerships

    Science.gov (United States)

    Murdock, Alan K.

    2017-01-01

    Forsyth Technical Community College (FTCC) face a shortage of funding to meet the demands of students, faculty, staff and businesses. Through this practitioner research, the utilization of the college's current customer relationship management (CRM) database advanced. By leveraging technology, the researcher assisted the college in meeting the…

  6. Do Mathematics and Reading Competencies Integrated into Career and Technical Education Courses Improve High School Student State Assessment Scores?

    Science.gov (United States)

    Pierce, Kristin B.; Hernandez, Victor M.

    2015-01-01

    A quasi experimental study tested a contextual teaching and learning model for integrating reading and mathematics competencies through 13 introductory career and technical education (CTE) courses. The treatment group consisted of students in the 13 introductory courses taught by the CTE teachers who designed the units and the control group…

  7. What Animated Illustrations Conditions Can Improve Technical Document Comprehension in Young Students? Format, Signaling and Control of the Presentation

    Science.gov (United States)

    Boucheix, Jean-Michel; Guignard, Helene

    2005-01-01

    We study the comprehension of a multimedia technical document about gear functioning by young pupils. The research is focused on the effect of three factors on the construction of a mental model: illustration format (animated versus static) signaling cues (presence versus absence) learner-control of information delivery (three rhythms of…

  8. Improving Evolutionary Models for Mitochondrial Protein Data with Site-Class Specific Amino Acid Exchangeability Matrices

    Science.gov (United States)

    Dunn, Katherine A.; Jiang, Wenyi; Field, Christopher; Bielawski, Joseph P.

    2013-01-01

    Adequate modeling of mitochondrial sequence evolution is an essential component of mitochondrial phylogenomics (comparative mitogenomics). There is wide recognition within the field that lineage-specific aspects of mitochondrial evolution should be accommodated through lineage-specific amino-acid exchangeability matrices (e.g., mtMam for mammalian data). However, such a matrix must be applied to all sites and this implies that all sites are subject to the same, or largely similar, evolutionary constraints. This assumption is unjustified. Indeed, substantial differences are expected to arise from three-dimensional structures that impose different physiochemical environments on individual amino acid residues. The objectives of this paper are (1) to investigate the extent to which amino acid evolution varies among sites of mitochondrial proteins, and (2) to assess the potential benefits of explicitly modeling such variability. To achieve this, we developed a novel method for partitioning sites based on amino acid physiochemical properties. We apply this method to two datasets derived from complete mitochondrial genomes of mammals and fish, and use maximum likelihood to estimate amino acid exchangeabilities for the different groups of sites. Using this approach we identified large groups of sites evolving under unique physiochemical constraints. Estimates of amino acid exchangeabilities differed significantly among such groups. Moreover, we found that joint estimates of amino acid exchangeabilities do not adequately represent the natural variability in evolutionary processes among sites of mitochondrial proteins. Significant improvements in likelihood are obtained when the new matrices are employed. We also find that maximum likelihood estimates of branch lengths can be strongly impacted. We provide sets of matrices suitable for groups of sites subject to similar physiochemical constraints, and discuss how they might be used to analyze real data. We also discuss how

  9. Improving evolutionary models for mitochondrial protein data with site-class specific amino acid exchangeability matrices.

    Directory of Open Access Journals (Sweden)

    Katherine A Dunn

    Full Text Available Adequate modeling of mitochondrial sequence evolution is an essential component of mitochondrial phylogenomics (comparative mitogenomics. There is wide recognition within the field that lineage-specific aspects of mitochondrial evolution should be accommodated through lineage-specific amino-acid exchangeability matrices (e.g., mtMam for mammalian data. However, such a matrix must be applied to all sites and this implies that all sites are subject to the same, or largely similar, evolutionary constraints. This assumption is unjustified. Indeed, substantial differences are expected to arise from three-dimensional structures that impose different physiochemical environments on individual amino acid residues. The objectives of this paper are (1 to investigate the extent to which amino acid evolution varies among sites of mitochondrial proteins, and (2 to assess the potential benefits of explicitly modeling such variability. To achieve this, we developed a novel method for partitioning sites based on amino acid physiochemical properties. We apply this method to two datasets derived from complete mitochondrial genomes of mammals and fish, and use maximum likelihood to estimate amino acid exchangeabilities for the different groups of sites. Using this approach we identified large groups of sites evolving under unique physiochemical constraints. Estimates of amino acid exchangeabilities differed significantly among such groups. Moreover, we found that joint estimates of amino acid exchangeabilities do not adequately represent the natural variability in evolutionary processes among sites of mitochondrial proteins. Significant improvements in likelihood are obtained when the new matrices are employed. We also find that maximum likelihood estimates of branch lengths can be strongly impacted. We provide sets of matrices suitable for groups of sites subject to similar physiochemical constraints, and discuss how they might be used to analyze real data. We

  10. Elimination of pain improves specificity of clinical diagnostic criteria for adult chronic rhinosinusitis.

    Science.gov (United States)

    Hirsch, Scott D; Reiter, Evan R; DiNardo, Laurence J; Wan, Wen; Schuman, Theodore A

    2017-05-01

    Determine whether the elimination of pain improves accuracy of clinical diagnostic criteria for adult chronic rhinosinusitis. Retrospective cohort study. History, symptoms, nasal endoscopy, and computed tomography (CT) results were analyzed for 1,186 adults referred to an academic otolaryngology clinic with presumptive diagnosis of chronic rhinosinusitis. Clinical diagnosis was rendered using the 1997 Rhinosinusitis Taskforce (RSTF) Guidelines and a modified version eliminating facial pain, ear pain, dental pain, and headache. Four hundred seventy-nine subjects (40%) met inclusion criteria. Among subjects positive by RSTF guidelines, 45% lacked objective evidence of sinonasal inflammation by CT, 48% by endoscopy, and 34% by either modality. Applying modified RSTF diagnostic criteria, 39% lacked sinonasal inflammation by CT, 38% by endoscopy, and 24% by either modality. Using either abnormal CT or endoscopy as the reference standard, modified diagnostic criteria yielded a statistically significant increase in specificity from 37.1% to 65.1%, with a nonsignificant decrease in sensitivity from 79.2% to 70.3%. Analysis of comorbidities revealed temporomandibular joint disorder, chronic cervical pain, depression/anxiety, and psychiatric medication use to be negatively associated with objective inflammation on CT or endoscopy. Clinical diagnostic criteria overestimate the prevalence of chronic rhinosinusitis. Removing facial pain, ear pain, dental pain, and headache increased specificity without a concordant loss in sensitivity. Given the high prevalence of sinusitis, improved clinical diagnostic criteria may assist primary care providers in more accurately predicting the presence of inflammation, thereby reducing inappropriate antibiotic use or delayed referral for evaluation of primary headache syndromes. 4. Laryngoscope, 127:1011-1016, 2017. © 2017 The American Laryngological, Rhinological and Otological Society, Inc.

  11. Memory specificity training can improve working and prospective memory in amnestic mild cognitive impairment.

    Science.gov (United States)

    Emsaki, Golita; NeshatDoost, Hamid Taher; Tavakoli, Mahgol; Barekatain, Majid

    2017-01-01

    Amnestic Mild Cognitive Impairment (MCI) is one of the cognitive profiles of aging. In this study, Memory Specificity Training (MEST) was used as cognitive training in patients with amnestic MCI to understand the effectiveness of the intervention on memory dimensions. Twenty patients that met the criteria for amnestic MCI were selected and randomly assigned to experimental (n=10) or control (n=10) groups. The experimental group received five sessions of training on memory specificity while the participants in the control group took part in two general placebo sessions. Participants were assessed before, immediately after, and three months after, the treatment using the Autobiographical Memory Test, the Prospective and Retrospective Memory Questionnaire, the Wechsler Memory Scale, and the Hospital Anxiety and Depression Scale. Analysis of variance was used to analyze the data. Results from both post-test and follow-up treatment indicated that MEST improves working and prospective memory (p<0.05). These findings support the effectiveness of MEST for MCI patients as a viable cognitive intervention. Also, the findings have implications for the role of brain plasticity in the effectiveness of this intervention.

  12. Motor Training in Degenerative Spinocerebellar Disease: Ataxia-Specific Improvements by Intensive Physiotherapy and Exergames

    Science.gov (United States)

    2014-01-01

    The cerebellum is essentially involved in movement control and plays a critical role in motor learning. It has remained controversial whether patients with degenerative cerebellar disease benefit from high-intensity coordinative training. Moreover, it remains unclear by which training methods and mechanisms these patients might improve their motor performance. Here, we review evidence from different high-intensity training studies in patients with degenerative spinocerebellar disease. These studies demonstrate that high-intensity coordinative training might lead to a significant benefit in patients with degenerative ataxia. This training might be based either on physiotherapy or on whole-body controlled videogames (“exergames”). The benefit shown in these studies is equal to regaining one or more years of natural disease progression. In addition, first case studies indicate that even subjects with advanced neurodegeneration might benefit from such training programs. For both types of training, the observed clinical improvements are paralleled by recoveries in ataxia-specific dysfunctions (e.g., multijoint coordination and dynamic stability). Importantly, for both types of training, the retention of the effects seems to depend on the frequency and continuity of training. Based on these studies, we here present preliminary recommendations for clinical practice, and articulate open questions that might guide future studies on neurorehabilitation in degenerative spinocerebellar disease. PMID:24877117

  13. Behavioural improvements and emotional gains for students attending an Australian School for Specific Purposes.

    Science.gov (United States)

    Hulme, Melissa J; Cornish, Alison M

    2015-10-01

    Outcomes of students with behavioural and emotional difficulties attending a specialised educational programme, delivered in a tertiary education and health facility, were evaluated and compared with Australian normative data. A total of 45 students (5-10 years old) attending the school in Sydney, New South Wales, were identified. At enrolment, parent ratings on the Strengths and Difficulties Questionnaire (SDQ) significantly deviated from Australian normative data on all scales for males and on the overall score, conduct and hyperactivity scales for females. Clinically significant levels of hyperactivity, peer problems and conduct symptoms were identified. After an average attendance at the school of 8.82 months, ratings on the Children's Global Assessment Scale (CGAS) indicated improved overall functioning, alongside specific improvements on SDQ rated emotion, conduct and social symptoms, and in Health of the Nation Outcomes Scales Child and Adolescent (HoNOSCA) rated social impairment and parents' reported need for information about their child's condition. Male students' emotional symptoms no longer differed from those of typical Australian students. The findings provide initial evidence for the effectiveness of a multimodal, flexible and targeted school programme in remediating key student mental health symptoms. It is suggested that major concepts from attachment theory and explicitly taught behavioural skills are key elements of this unique programme that contribute to its apparent effectiveness. © The Author(s) 2014.

  14. Wavenumber selection based analysis in Raman spectroscopy improves skin cancer diagnostic specificity.

    Science.gov (United States)

    Zhao, Jianhua; Zeng, Haishan; Kalia, Sunil; Lui, Harvey

    2016-02-07

    Real-time Raman spectroscopy can be used to assist in assessing skin lesions suspicious for cancer. Most of the diagnostic algorithms are based on full band of the Raman spectra, either in the fingerprint region or the high wavenumber region. In this paper we explored wavenumber selection based analysis in Raman spectroscopy for skin cancer diagnosis. Wavenumber selection was implemented using windows of wavenumber and leave-one-out cross-validated stepwise regression or least and shrinkage selection operator (LASSO). The diagnostic algorithms were then generated from the selected windows of wavenumber using multivariate statistical analyses, including principal component and general discriminate analysis (PC-GDA) and partial least squares (PLS). In total a combined cohort of 645 confirmed lesions from 573 patients encompassing skin cancers, precancers and benign skin lesions were included, which were divided into training cohort (n = 518) and testing cohort (n = 127) according to the measurement time. It was found that the area under the receiver operating characteristic curve (ROC) was improved from 0.861-0.891 to 0.891-0.911 and the diagnostic specificity for fixed sensitivity 0.99-0.90 was improved from 0.17-0.65 to 0.20-0.75 with wavenumber selection based analysis.

  15. Optimization on the impeller of a low-specific-speed centrifugal pump for hydraulic performance improvement

    Science.gov (United States)

    Pei, Ji; Wang, Wenjie; Yuan, Shouqi; Zhang, Jinfeng

    2016-09-01

    In order to widen the high-efficiency operating range of a low-specific-speed centrifugal pump, an optimization process for considering efficiencies under 1.0 Q d and 1.4 Q d is proposed. Three parameters, namely, the blade outlet width b 2, blade outlet angle β 2, and blade wrap angle φ, are selected as design variables. Impellers are generated using the optimal Latin hypercube sampling method. The pump efficiencies are calculated using the software CFX 14.5 at two operating points selected as objectives. Surrogate models are also constructed to analyze the relationship between the objectives and the design variables. Finally, the particle swarm optimization algorithm is applied to calculate the surrogate model to determine the best combination of the impeller parameters. The results show that the performance curve predicted by numerical simulation has a good agreement with the experimental results. Compared with the efficiencies of the original impeller, the hydraulic efficiencies of the optimized impeller are increased by 4.18% and 0.62% under 1.0 Q d and 1.4Qd, respectively. The comparison of inner flow between the original pump and optimized one illustrates the improvement of performance. The optimization process can provide a useful reference on performance improvement of other pumps, even on reduction of pressure fluctuations.

  16. Specific Physical Exercise Improves Energetic Metabolism in the Skeletal Muscle of Amyotrophic-Lateral- Sclerosis Mice

    Directory of Open Access Journals (Sweden)

    Céline Desseille

    2017-10-01

    Full Text Available Amyotrophic Lateral Sclerosis is an adult-onset neurodegenerative disease characterized by the specific loss of motor neurons, leading to muscle paralysis and death. Although the cellular mechanisms underlying amyotrophic lateral sclerosis (ALS-induced toxicity for motor neurons remain poorly understood, growing evidence suggest a defective energetic metabolism in skeletal muscles participating in ALS-induced motor neuron death ultimately destabilizing neuromuscular junctions. In the present study, we report that a specific exercise paradigm, based on a high intensity and amplitude swimming exercise, significantly improves glucose metabolism in ALS mice. Using physiological tests and a biophysics approach based on nuclear magnetic resonance (NMR, we unexpectedly found that SOD1(G93A ALS mice suffered from severe glucose intolerance, which was counteracted by high intensity swimming but not moderate intensity running exercise. Furthermore, swimming exercise restored the highly ALS-sensitive tibialis muscle through an autophagy-linked mechanism involving the expression of key glucose transporters and metabolic enzymes, including GLUT4 and glyceraldehyde-3-phosphate dehydrogenase (GAPDH. Importantly, GLUT4 and GAPDH expression defects were also found in muscles from ALS patients. Moreover, we report that swimming exercise induced a triglyceride accumulation in ALS tibialis, likely resulting from an increase in the expression levels of lipid transporters and biosynthesis enzymes, notably DGAT1 and related proteins. All these data provide the first molecular basis for the differential effects of specific exercise type and intensity in ALS, calling for the use of physical exercise as an appropriate intervention to alleviate symptoms in this debilitating disease.

  17. Rapid Development and Characterization of Chromosome Specific Translocation Line of Thinopyrum elongatum with Improved Dough Strength

    Directory of Open Access Journals (Sweden)

    Aman Kumar

    2017-09-01

    Full Text Available The protein content and its type are principal factors affecting wheat (Triticum aestivum end product quality. Among the wheat proteins, glutenin proteins, especially, high molecular weight glutenin subunits (HMW-GS are major determinants of processing quality. Wheat and its primary gene pool have limited variation in terms of HMW-GS alleles. Wild relatives of wheat are an important source of genetic variation. For improvement of wheat processing quality its wild relative Thinopyrum elongatum with significant potential was utilized. An attempt was made to replace Th. elongatum chromosome long arm (1EL carrying HMW-GS genes related to high dough strength with chromosome 1AL of wheat with least or negative effect on dough strength while retaining the chromosomes 1DL and 1BL with a positive effect on bread making quality. To create chromosome specific translocation line [1EL(1AS], double monosomic of chromosomes 1E and 1A were created and further crossed with different cultivars and homoeologous pairing suppressor mutant line PhI. The primary selection was based upon glutenin and gliadin protein profiles, followed by sequential genomic in situ hybridization (GISH and fluorescent in situ hybridization (FISH. These steps significantly reduced time, efforts, and economic cost in the generation of translocation line. In order to assess the effect of translocation on wheat quality, background recovery was carried out by backcrossing with recurrent parent for several generations and then selfing while selecting in each generation. Good recovery of parent background indicated the development of almost near isogenic line (NIL. Morphologically also translocation line was similar to recipient cultivar N61 that was further confirmed by seed storage protein profiles, RP-HPLC and scanning electron microscopy. The processing quality characteristics of translocation line (BC4F6 indicated significant improvement in the gluten performance index (GPI, dough mixing

  18. Specific PVMaT R and D in CdTe Product Manufacturing; Phase II Annual Subcontract Technical Report; May 1999--September 2000

    Energy Technology Data Exchange (ETDEWEB)

    McMaster, A. (First Solar, LLC)

    2001-01-22

    Just prior to the beginning of Phase II of the PVMaT project Solar Cells, Inc, (SCI) and True North Partners of Scottsdale, AZ, formed a joint venture partnership name First Solar, LLC. By the end of 1999, this event resulted in the construction of a new major manufacturing plant for photovoltaic modules, based on cadmium telluride, located in Perrysburg, a suburb of Toledo, Ohio. This plant was designed to be capable of producing PV modules at a rate of 100 MW per year within about three years. Significantly, a new semiconductor coating system, the heat of the production line, has already shown the capability of the 100 MW per year rate. These events have led to the expansion of the effort on the PVMaT project that included the former SCI team in Toledo, Ohio, a new team of engineering subcontractor, Product Search, Inc., and, later, a new laser team from First Solar, both from Scottsdale, Arizona. These three teams joined in a collaborative effort on Tasks 4: Manufacturing Line Improvements, on Task 5: Product Readiness, and on Task Environmental, Health, and Safety Issues. One Task 4 goal was to address the technical issues of the failed UL 1703 qualification testing in Phase I. Completing this goal, along with module lamination improvement done in Task 5, was instrumental in the design, fabrication, and installation of a high-throughput solar finishing line. The main components of this line, also a Task 4 project, were successfully tested in module finalization on the production line. Developing a novel, single-laser scribing system was another major accomplishment. In Task 5, the major activity was improved module lamination. Progress in Tasks 4 and 5 resulted in improved modules that were submitted for UL 1703 qualification testing. In March 2000, a new encapsulation process came under development, in which the back glass cover plate is substituted by a combination of a polymer layer as a dielectric and aluminum foil as a moisture barrier. The go al of the

  19. Improved adhesive properties of recombinant bifidobacteria expressing the Bifidobacterium bifidum-specific lipoprotein BopA

    Directory of Open Access Journals (Sweden)

    Gleinser Marita

    2012-06-01

    Full Text Available Abstract Background Bifidobacteria belong to one of the predominant bacterial groups in the intestinal microbiota of infants and adults. Several beneficial effects on the health status of their human hosts have been demonstrated making bifidobacteria interesting candidates for probiotic applications. Adhesion of probiotics to the intestinal epithelium is discussed as a prerequisite for colonisation of and persistence in the gastrointestinal tract. Results In the present study, 15 different strains of bifidobacteria were tested for adhesion. B. bifidum was identified as the species showing highest adhesion to all tested intestinal epithelial cell (IEC lines. Adhesion of B. bifidum S17 to IECs was strongly reduced after treatment of bacteria with pronase. These results strongly indicate that a proteinaceous cell surface component mediates adhesion of B. bifidum S17 to IECs. In silico analysis of the currently accessible Bifidobacterium genomes identified bopA encoding a lipoprotein as a B. bifidum-specific gene previously shown to function as an adhesin of B. bifidum MIMBb75. The in silico results were confirmed by Southern Blot analysis. Furthermore, Northern Blot analysis demonstrated that bopA is expressed in all B. bifidum strains tested under conditions used to cultivate bacteria for adhesion assays. The BopA gene was successfully expressed in E. coli and purified by Ni-NTA affinity chromatography as a C-terminal His6-fusion. Purified BopA had an inhibitory effect on adhesion of B. bifidum S17 to IECs. Moreover, bopA was successfully expressed in B. bifidum S17 and B. longum/infantis E18. Strains overexpressing bopA showed enhanced adhesion to IECs, clearly demonstrating a role of BopA in adhesion of B. bifidum strains. Conclusions BopA was identified as a B. bifidum-specific protein involved in adhesion to IECs. Bifidobacterium strains expressing bopA show enhanced adhesion. Our results represent the first report on recombinant

  20. Improvement in Neuropathy Specific Quality of Life in Patients with Diabetes after Vitamin D Supplementation

    Directory of Open Access Journals (Sweden)

    Uazman Alam

    2017-01-01

    Full Text Available Objective. To assess the effect of vitamin D supplementation on neuropathy specific quality of life (NeuroQoL in patients with painful diabetic neuropathy. Methods. This prospective, open label study was conducted between June 2012 and April 2013. Patients with symptomatic diabetic neuropathy were given a single dose of 600,000 IU intramuscular vitamin D, and NeuroQol was assessed at baseline and at five follow-up visits every 4 weeks. Results. Of 143 participants, 41.3% were vitamin D deficient (vitamin D < 20 ng/ml. Treatment with vitamin D resulted in a significant increase in 25(OHD (P<0.0001 and a significant improvement in the NeuroQoL subscale score for emotional distress (P=0.04, with no significant change in the other NeuroQoL domains of painful symptoms and paresthesia, loss of temperature and touch sensation, unsteadiness, limitation in daily activities, and interpersonal problems. There was a significant reduction in patient perception about foot problems on QoL of “quite a lot” (P<0.05 and “very much” (P<0.0001 with a significant reduction in the baseline response of having a “poor” QoL from 5.2% to 0.7% (P<0.0001 and an increase in the response of an “excellent QoL” from 1.5% to 7.4% (P<0.0001. Conclusion. Vitamin D is effective in improving quality of life in patients with painful diabetic neuropathy.

  1. Platelet-Specific p38α Deficiency Improved Cardiac Function After Myocardial Infarction in Mice.

    Science.gov (United States)

    Shi, Panlai; Zhang, Lin; Zhang, Mingliang; Yang, Wenlong; Wang, Kemin; Zhang, Junfeng; Otsu, Kinya; Huang, Gonghua; Fan, Xuemei; Liu, Junling

    2017-12-01

    MAPKs (mitogen-activated protein kinases), especially p38, play detrimental roles in cardiac diseases and cardiac remodeling post-myocardial infarction. However, the activation and function of MAPKs in coronary thrombosis in vivo and its relationship with clinical outcomes remain poorly understood. Here, we showed that p38α was the major isoform expressed in human and mouse platelets. Platelet-specific p38α-deficient mice presented impaired thrombosis and hemostasis but had improved cardiac function, reduced infarct size, decreased inflammatory response, and microthrombus in a left anterior descending artery ligation model. Signaling analysis revealed that p38 activation was one of the earliest events in platelets after treatment with receptor agonists or reactive oxygen species. p38α/MAPK-activated protein kinase 2/heat shock protein 27 and p38α/cytosolic phospholipases A2 were the major pathways regulating receptor-mediated or hydrogen peroxide-induced platelet activation in an ischemic environment. Moreover, the distinct roles of ERK1/2 (extracellular signal-regulated kinase) in receptor- or reactive oxygen species-induced p38-mediated platelet activation reflected the complicated synergistic relationships among MAPKs. Analysis of clinical samples revealed that MAPKs were highly phosphorylated in platelets from preoperative patients with ST-segment-elevation myocardial infarction, and increased phosphorylation of p38 was associated with no-reflow outcomes. We conclude that p38α serves as a critical regulator of platelet activation and potential indicator of highly thrombotic lesions and no-reflow, and inhibition of platelet p38α may improve clinical outcomes in subjects with ST-segment-elevation myocardial infarction. © 2017 American Heart Association, Inc.

  2. Tissue specific promoters improve the localization of radiation-inducible gene expression

    International Nuclear Information System (INIS)

    Hallahan, Dennis; Kataoka, Yasushi; Kuchibhotla, Jaya; Virudachalam, Subbu; Weichselbaum, Ralph

    1996-01-01

    expression was quantified in vascular endothelial cells from large vessel (HUVEC) and small vessels (HMEC). We found cell-type specificity of radiation-induction. The promoter region from the ELAM gene gave no expression in cells that were not of endothelial cell origin and x-ray-induction of ELAM in the endothelium required the NFkB binding cis-acting element. ELAM induction was achieved at doses as low as 1 Gy, whereas induction of other radiation inducible genes required 5 to 10 Gy. Cells transfected with the minimal promoter (plasmid pTK-CAT) demonstrated no radiation induction. Expression of the CMV-LacZ genetic construct that was used as a negative control in each transfection was not altered by x-irradiation. Moreover, intravenous administration of liposomes containing a reporter gene linked to the ELAM promoter and a transcriptional amplification system were induced specifically at sites of x-irradiation in an animal model. Conclusions: Activation of transcription of the ELAM-1 promoter by ionizing radiation is a means of activating gene therapy within the vascular endothelium and demonstrates the feasibility of treating vascular lesions with noninvasive procedures. Tissue specific promoters (e. g., ELAM-1) combined with radiation inducible gene therapy improves the localization of gene therapy expression. These results have applications in intravascular brachytherapy for the prevention of blood vessel restenosis

  3. Improving a health information system for real-time data entries: An action research project using socio-technical systems theory.

    Science.gov (United States)

    Adaba, Godfried Bakiyem; Kebebew, Yohannes

    2018-03-01

    This paper presents the findings of an action research (AR) project to improve a health information system (HIS) at the Operating Theater Department (OTD) of a National Health Service (NHS) hospital in South East England, the UK. Informed by socio-technical systems (STS) theory, AR was used to design an intervention to enhance an existing patient administration system (PAS) to enable data entries in real time while contributing to the literature. The study analyzed qualitative data collected through interviews, participant observations, and document reviews. The study found that the design of the PAS was unsuitable to the work of the three units of the OTD. Based on the diagnoses and STS theory, the project developed and implemented a successful intervention to enhance the legacy system for data entries in real time. The study demonstrates the value of AR from a socio-technical perspective for improving existing systems in healthcare settings. The steps adopted in this study could be applied to improve similar systems. A follow-up study will be essential to assess the sustainability of the improved system.

  4. Improving listening comprehension skills relying on metacognitive strategies - focus on vocabulary and specific l2 instruction

    Directory of Open Access Journals (Sweden)

    Jerotijević-Tišma Danica

    2016-01-01

    Full Text Available The present paper aims at investigating the application of an instructional method specifically focused on the expansion of metacognitive awareness and its effect on Serbian EFL students’ listening comprehension. The current study is a follow-up research of a similar study by Vandergrift and Tafaghodtari (2010. However, we sought to expand the previous research by investigating the relationship between the students’ current level of L2 (target language vocabulary and listening test scores. Our study likewise differed in the sample of participants, the target language, teaching and testing material used, and the duration of the very experiment. To answer the proposed research questions we conducted an experiment with 57 Serbian secondary school EFL (English as a Foreign Language learners divided into experimental (n=27 and control group (n=30. The results of the pre- and post-tests of the two groups showed the beneficial effects of developing metacognitive strategies and the strong positive correlation between the level of vocabulary and listening comprehension. The paper underlines important pedagogical implications especially regarding the enhancement of metacognitive awareness and vocabulary proficiency of students in order to improve performance on listening comprehension tasks.

  5. Silicon improves rice grain yield and photosynthesis specifically when supplied during the reproductive growth stage.

    Science.gov (United States)

    Lavinsky, Alyne O; Detmann, Kelly C; Reis, Josimar V; Ávila, Rodrigo T; Sanglard, Matheus L; Pereira, Lucas F; Sanglard, Lílian M V P; Rodrigues, Fabrício A; Araújo, Wagner L; DaMatta, Fábio M

    2016-11-01

    Silicon (Si) has been recognized as a beneficial element to improve rice (Oryza sativa L.) grain yield. Despite some evidence suggesting that this positive effect is observed when Si is supplied along the reproductive growth stage (from panicle initiation to heading), it remains unclear whether its supplementation during distinct growth phases can differentially impact physiological aspects of rice and its yield and the underlying mechanisms. Here, we investigated the effects of additions/removals of Si at different growth stages and their impacts on rice yield components, photosynthetic performance, and expression of genes (Lsi1, Lsi2 and Lsi6) involved in Si distribution within rice shoots. Positive effects of Si on rice production and photosynthesis were manifested when it was specifically supplied during the reproductive growth stage, as demonstrated by: (1) a high crop yield associated with higher grain number and higher 1000-grain weight, whereas the leaf area and whole-plant biomass remained unchanged; (2) an increased sink strength which, in turn, exerted a feed-forward effect on photosynthesis that was coupled with increases in both stomatal conductance and biochemical capacity to fix CO 2 ; (3) higher Si amounts in the developing panicles (and grain husks) in good agreement with a remarkable up-regulation of Lsi6 (and to a lesser extent Lsi1). We suggest that proper levels of Si in these reproductive structures seem to play an as yet unidentified role culminating with higher grain number and size. Copyright © 2016 Elsevier GmbH. All rights reserved.

  6. The Effect of Femoral Cutting Guide Design Improvements for Patient-Specific Instruments

    Directory of Open Access Journals (Sweden)

    Oh-Ryong Kwon

    2015-01-01

    Full Text Available Although the application of patient-specific instruments (PSI for total knee arthroplasty (TKA increases the cost of the surgical procedure, PSI may reduce operative time and improve implant alignment, which could reduce the number of revision surgeries. We report our experience with TKA using PSI techniques in 120 patients from March to December 2014. PSI for TKA were created from data provided by computed tomography (CT scans or magnetic resonance imaging (MRI; which imaging technology is more reliable for the PSI technique remains unclear. In the first 20 patients, the accuracy of bone resection and PSI stability were compared between CT and MRI scans with presurgical results as a reference; MRI produced better results. In the second and third groups, each with 50 patients, the results of bone resection and stability were compared in MRI scans with respect to the quality of scanning due to motion artifacts and experienced know-how in PSI design, respectively. The optimized femoral cutting guide design for PSI showed the closest outcomes in bone resection and PSI stability with presurgical data. It is expected that this design could be a reasonable guideline in PSI.

  7. Technical presentation

    CERN Multimedia

    GS Department

    2010-01-01

    10 March 2010 DYNEOS 10:00 – 12:00 - Main Building, Room B, 61-1-009 Dyneos AG is active in the fields of photonics, laser and high-precision positioning. Our highly qualified engineer team has more than 30 years of experience in electro-optical solutions sales. The engineers are supported by a technical and administrative team. We are focused on the Swiss market and represent six suppliers (Coherent, PI Physik Instrumente, SIOS, Nanonics Imaging, APE, Ekspla) in order to give a qualified sales and service support to our customers. Our products are dedicated to the research field as well as to industry. In addition to standard catalog products, we offer custom designs to fulfill the specific needs of OEM customers or specific applications.

  8. Improving the non-technical skills of hospital medical emergency teams: The Team Emergency Assessment Measure (TEAM™).

    Science.gov (United States)

    Cant, Robyn P; Porter, Joanne E; Cooper, Simon J; Roberts, Kate; Wilson, Ian; Gartside, Christopher

    2016-12-01

    This prospective descriptive study aimed to test the validity and feasibility of the Team Emergency Assessment Measure (TEAM™) for assessing real-world medical emergency teams' non-technical skills. Second, the present study aimed to explore the instrument's contribution to practice regarding teamwork and learning outcomes. Registered nurses (RNs) and medical staff (n = 104) in two hospital EDs in rural Victoria, Australia, participated. Over a 10 month period, the (TEAM™) instrument was completed by multiple clinicians at medical emergency episodes. In 80 real-world medical emergency team resuscitation episodes (283 clinician assessments), non-technical skills ratings averaged 89% per episode (39 of a possible 44 points). Twenty-one episodes were rated in the lowest quartile (i.e. ≤37 points out of 44). Ratings differed by discipline, with significantly higher scores given by medical raters (mean: 41.1 ± 4.4) than RNs (38.7 ± 5.4) (P = 0.001). This difference occurred in the Leadership domain. The tool was reliable with Cronbach's alpha 0.78, high uni-dimensional validity and mean inter-item correlation of 0.45. Concurrent validity was confirmed by strong correlation between TEAM™ score and the awarded Global Rating (P technical skills of medical emergency teams are known to often be suboptimal; however, average ratings of 89% were achieved in this real-world study. TEAM™ is a valid, reliable and easy to use tool, for both training and clinical settings, with benefits for team performance when used as an assessment and/or debriefing tool. © 2016 Australasian College for Emergency Medicine and Australasian Society for Emergency Medicine.

  9. Technical Note: Improved total atmospheric water vapour amount determination from near-infrared filter measurements with sun photometers

    Directory of Open Access Journals (Sweden)

    F. Mavromatakis

    2007-09-01

    Full Text Available In this work we explore the effect of the contribution of the solar spectrum to the recorded signal in wavelengths outside the typical 940-nm filter's bandwidth. We employ gaussian-shaped filters as well as actual filter transmission curves, mainly AERONET data, to study the implications imposed by the non-zero out-of-band contribution to the coefficients used to derive precipitable water from the measured water vapour band transmittance. Published parameterized transmittance functions are applied to the data to determine the filter coefficients. We also introduce an improved, three-parameter, fitting function that can describe the theoretical data accurately, with significantly less residual effects than with the existing functions. The moderate-resolution SMARTS radiative transfer code is used to predict the incident spectrum outside the filter bandpass for different atmospheres, solar geometries and aerosol optical depths. The high-resolution LBLRTM radiative transfer code is used to calculate the water vapour transmittance in the 940-nm band. The absolute level of the out-of-band transmittance has been chosen to range from 10−6 to 10−4, and typical response curves of commercially available silicon photodiodes are included into the calculations.

    It is shown that if the out-of-band transmittance effect is neglected, as is generally the case, then the derived columnar water vapour is mainly underestimated by a few percents. The actual error depends on the specific out-of-band transmittance, optical air mass of observation and water vapour amount. Further investigations will use experimental data from field campaigns to validate these findings.

  10. Teaching a Story Mapping Procedure to High School Students with Specific Learning Disabilities to Improve Reading Comprehension Skills

    Science.gov (United States)

    Fore, Cecil, III; Scheiwe, Kimberly; Burke, Mack D.; Boon, Richard T.

    2007-01-01

    The purpose of this study was to evaluate the effectiveness of the direct instruction of story mapping in improving the reading comprehension for high school students with specific learning disabilities. The participants included four eleventh grade students with specific learning disabilities served for literature in a resource room in a public…

  11. Simulation-based ureteroscopy skills training curriculum with integration of technical and non-technical skills: a randomised controlled trial.

    Science.gov (United States)

    Brunckhorst, Oliver; Shahid, Shahab; Aydin, Abdullatif; McIlhenny, Craig; Khan, Shahid; Raza, Syed Johar; Sahai, Arun; Brewin, James; Bello, Fernando; Kneebone, Roger; Khan, Muhammad Shamim; Dasgupta, Prokar; Ahmed, Kamran

    2015-09-01

    Current training modalities within ureteroscopy have been extensively validated and must now be integrated within a comprehensive curriculum. Additionally, non-technical skills often cause surgical error and little research has been conducted to combine this with technical skills teaching. This study therefore aimed to develop and validate a curriculum for semi-rigid ureteroscopy, integrating both technical and non-technical skills teaching within the programme. Delphi methodology was utilised for curriculum development and content validation, with a randomised trial then conducted (n = 32) for curriculum evaluation. The developed curriculum consisted of four modules; initially developing basic technical skills and subsequently integrating non-technical skills teaching. Sixteen participants underwent the simulation-based curriculum and were subsequently assessed, together with the control cohort (n = 16) within a full immersion environment. Both technical (Time to completion, OSATS and a task specific checklist) and non-technical (NOTSS) outcome measures were recorded with parametric and non-parametric analyses used depending on the distribution of our data as evaluated by a Shapiro-Wilk test. Improvements within the intervention cohort demonstrated educational value across all technical and non-technical parameters recorded, including time to completion (p technical and non-technical skills teaching is both educationally valuable and feasible. Additionally, the curriculum offers a validated simulation-based training modality within ureteroscopy and a framework for the development of other simulation-based programmes.

  12. An improved estimator for the hydration of fat-free mass from in vivo measurements subject to additive technical errors

    International Nuclear Information System (INIS)

    Kinnamon, Daniel D; Ludwig, David A; Lipshultz, Steven E; Miller, Tracie L; Lipsitz, Stuart R

    2010-01-01

    The hydration of fat-free mass, or hydration fraction (HF), is often defined as a constant body composition parameter in a two-compartment model and then estimated from in vivo measurements. We showed that the widely used estimator for the HF parameter in this model, the mean of the ratios of measured total body water (TBW) to fat-free mass (FFM) in individual subjects, can be inaccurate in the presence of additive technical errors. We then proposed a new instrumental variables estimator that accurately estimates the HF parameter in the presence of such errors. In Monte Carlo simulations, the mean of the ratios of TBW to FFM was an inaccurate estimator of the HF parameter, and inferences based on it had actual type I error rates more than 13 times the nominal 0.05 level under certain conditions. The instrumental variables estimator was accurate and maintained an actual type I error rate close to the nominal level in all simulations. When estimating and performing inference on the HF parameter, the proposed instrumental variables estimator should yield accurate estimates and correct inferences in the presence of additive technical errors, but the mean of the ratios of TBW to FFM in individual subjects may not

  13. Improvements in State and Local Planning for Mass Dispensing of Medical Countermeasures: The Technical Assistance Review Program, United States, 2007-2014.

    Science.gov (United States)

    Renard, Paul G; Vagi, Sara J; Reinold, Chris M; Silverman, Brenda L; Avchen, Rachel N

    2017-09-01

    To evaluate and describe outcomes of state and local medical countermeasure preparedness planning, which is critical to ensure rapid distribution and dispensing of a broad spectrum of life-saving medical assets during a public health emergency. We used 2007 to 2014 state and local data collected from the Centers for Disease Control and Prevention's Technical Assistance Review. We calculated descriptive statistics from 50 states and 72 local Cities Readiness Initiative jurisdictions that participated in the Technical Assistance Review annually. From 2007 to 2014, the average overall Technical Assistance Review score increased by 13% for states and 41% for Cities Readiness Initiative jurisdictions. In 2014, nearly half of states achieved the maximum possible overall score (100), and 94% of local Cities Readiness Initiative jurisdictions achieved a score of 90 or more. Despite challenges, effective and timely medical countermeasure distribution and dispensing is possible with appropriate planning, staff, and resources. However, vigilance in training, exercising, and improving plans from lessons learned in a sustained, coordinated way is critical to ensure continued public health preparedness success.

  14. Zone-specific logistic regression models improve classification of prostate cancer on multi-parametric MRI

    Energy Technology Data Exchange (ETDEWEB)

    Dikaios, Nikolaos; Halligan, Steve; Taylor, Stuart; Atkinson, David; Punwani, Shonit [University College London, Centre for Medical Imaging, London (United Kingdom); University College London Hospital, Departments of Radiology, London (United Kingdom); Alkalbani, Jokha; Sidhu, Harbir Singh [University College London, Centre for Medical Imaging, London (United Kingdom); Abd-Alazeez, Mohamed; Ahmed, Hashim U.; Emberton, Mark [University College London, Research Department of Urology, Division of Surgery and Interventional Science, London (United Kingdom); Kirkham, Alex [University College London Hospital, Departments of Radiology, London (United Kingdom); Freeman, Alex [University College London Hospital, Department of Histopathology, London (United Kingdom)

    2015-09-15

    To assess the interchangeability of zone-specific (peripheral-zone (PZ) and transition-zone (TZ)) multiparametric-MRI (mp-MRI) logistic-regression (LR) models for classification of prostate cancer. Two hundred and thirty-one patients (70 TZ training-cohort; 76 PZ training-cohort; 85 TZ temporal validation-cohort) underwent mp-MRI and transperineal-template-prostate-mapping biopsy. PZ and TZ uni/multi-variate mp-MRI LR-models for classification of significant cancer (any cancer-core-length (CCL) with Gleason > 3 + 3 or any grade with CCL ≥ 4 mm) were derived from the respective cohorts and validated within the same zone by leave-one-out analysis. Inter-zonal performance was tested by applying TZ models to the PZ training-cohort and vice-versa. Classification performance of TZ models for TZ cancer was further assessed in the TZ validation-cohort. ROC area-under-curve (ROC-AUC) analysis was used to compare models. The univariate parameters with the best classification performance were the normalised T2 signal (T2nSI) within the TZ (ROC-AUC = 0.77) and normalized early contrast-enhanced T1 signal (DCE-nSI) within the PZ (ROC-AUC = 0.79). Performance was not significantly improved by bi-variate/tri-variate modelling. PZ models that contained DCE-nSI performed poorly in classification of TZ cancer. The TZ model based solely on maximum-enhancement poorly classified PZ cancer. LR-models dependent on DCE-MRI parameters alone are not interchangeable between prostatic zones; however, models based exclusively on T2 and/or ADC are more robust for inter-zonal application. (orig.)

  15. Evaluation and capacity building to improve precollege science and mathematics achievement in the US: 10 CFR, Part 605. Technical progress report, June--December 1992

    Energy Technology Data Exchange (ETDEWEB)

    1992-12-31

    The National Center for Improving Science Education has undertaken activities to achieve evaluation goals for DOE`s Precollege programs: develop means to determine program quality; develop means for determining the contribution of DOE precollege programs to both teacher enhancement and student achievement; provide evaluation designs and instruments and reports of program quality and impact; and strengthen both DOE`s and the Labs` capacity to do both short- and long-term planning as well as deliver effective programs and evaluation. Appendices include evaluation/technical assistance report, profiling teacher research participation and teacher development programs, teacher surveys, impact assessment design, and teacher research participation programs anecdotes for 8 labs.

  16. Technical specifications, Braidwood Station Unit Nos. 1 and 2 (Docket Nos. STN 50-456 and STN 50-457): Appendix ''A'' to License No. NPF-72, [October 1986-July 1987

    International Nuclear Information System (INIS)

    1987-07-01

    The Braidwood Station, Units 1 and 2, technical specifications were prepared by the US Nuclear Regulatory Commission to set forth the limits, operating conditions, and other requirements applicable to a nuclear reactor facility as set forth in Section 50.36 of 10 CFR Part 50 for the protection of the health and safety of the public

  17. Technical specifications, South Texas Project, Unit Nos. 1 and 2 (Docket Nos. 50-498 and 50-499): Appendix ''A'' to License Nos. NPF-76 and NPF-78

    International Nuclear Information System (INIS)

    1989-01-01

    The South Texas Project, Unit Nos. 1 and 2, Technical Specifications were prepared by the US Nuclear Regulatory Commission to set forth the limits, operating conditions, and other requirements applicable to a nuclear reactor facility as set forth in Section 50.36 of 10 CFR Part 50 for the protection of the health and safety of the public

  18. Technical Specifications, South Texas Project, Unit Nos. 1 and 2 (Docket Nos. 50-498 and 50-499): Appendix ''A'' to License Nos. NPF-76 and NPF-80

    International Nuclear Information System (INIS)

    1989-03-01

    The South Texas Project, Unit Nos. 1 and 2, Technical Specifications were prepared by the US Nuclear Regulatory Commission to set forth the limits, operating conditions, and other requirements applicable to a nuclear reactor facility as set forth in Section 50.36 of 10 CFR Part 50 for the protection of the health and safety of the public

  19. A cognitive training intervention improves modality-specific attention in a randomized controlled trial of healthy older adults.

    Science.gov (United States)

    Mozolic, Jennifer L; Long, Ashley B; Morgan, Ashley R; Rawley-Payne, Melissa; Laurienti, Paul J

    2011-04-01

    Age-related deficits in cognitive and sensory function can result in increased distraction from background sensory stimuli. This randomized controlled trial investigated the effects of a cognitive training intervention aimed at helping healthy older adults suppress irrelevant auditory and visual stimuli. Sixty-six participants received 8 weeks of either the modality-specific attention training program or an educational lecture control program. Participants who completed the intervention program had larger improvements in modality-specific selective attention following training than controls. These improvements also correlated with reductions in bimodal integration during selective attention. Further, the intervention group showed larger improvements than the control group in non-trained domains such as processing speed and dual-task completion, demonstrating the utility of modality-specific attention training for improving cognitive function in healthy older adults. Copyright © 2009 Elsevier Inc. All rights reserved.

  20. Congener-specific analysis of polychlorinated naphthalenes (PCNs) in the major Chinese technical PCB formulation from a stored Chinese electrical capacitor.

    Science.gov (United States)

    Huang, Jun; Yu, Gang; Yamauchi, Makoto; Matsumura, Toru; Yamazaki, Norimasa; Weber, Roland

    2015-10-01

    Impurity of polychlorinated naphthalenes (PCNs) in commercial polychlorinated biphenyl (PCB) formulations has been recognized as a relevant source of PCNs in the environment. Congener-specific analysis of most main PCB formulations has been accomplished previously, excluding the Chinese product. The insulating oil in a stored Chinese electric capacitor containing the major Chinese technical formulation "PCB3" was sampled and tested by isotope dilution technology using high-resolution gas chromatography coupled to high-resolution mass spectrometry (HRGC/HRMS). The detected concentration of PCNs in the Chinese PCB oil sample was 1,307.5 μg/g and therefore significantly higher than that reported in PCB formulations from other countries, as well as that in the transformer oil (ASKAREL Nr 1740) additionally tested in the present study for comparison. Based on the measurement, the total amount of PCNs in Chinese PCB3 oil is estimated to be 7.8 t, which would mean only 0.005 % of global production of PCNs of 150,000 t. The homolog profile is similar to those of PCN in Aroclor 1262 and Clophen A40, where the contributions from hexa-CNs and hepta-CNs are predominant and accounted for similar proportions. The Toxic Equivalent Quantity (TEQ) concentration of dioxin-like PCN congeners is 0.47 μg TEQ/g, with the dominant contributors of CN-73 and CN-66/67. This TEQ content from PCN is higher than that in most other PCB formulations with the exemption of the Russian Sovol formulation. The total TEQ in the historic 6,000 t of the Chinese PCB3 formulation is estimated to be 2.8 kg TEQ.

  1. Selection and Breeding of Cattle in Asia: Strategies and Criteria for Improved Breeding. Prepared under the Framework of an RCA Project with the Technical Support of the Joint FAO/IAEA Programme of Nuclear Techniques in Food and Agriculture

    International Nuclear Information System (INIS)

    2009-10-01

    The International Atomic Energy Agency (IAEA) and the Regional Cooperative Agreement for Asia and the Pacific Region (RCA), with the technical support of the Joint FAO/IAEA Programme of Nuclear Techniques in Food and Agriculture, implemented a Technical Cooperation (TC) project entitled Integrated Approach for Improving Livestock Production Using Indigenous Resources and Conserving the Environment (RAS/5/044). The 23 project counterparts and the IAEA technical officer, based on the lack of standard practices in the region with regard to selection of cattle for breeding purposes, and the need to properly manage the genetic resources within each country for improving the productivity of the existing stock while maintaining the unique and beneficial genetic characteristics of the indigenous breeds, agreed during the first meeting to request the IAEA to recruit a group of experts with the task of preparing guidelines for the selection and breeding of cattle and buffalo on the Asian continent. To address these recommendations, an experts meeting on Selection Criteria for Breeding Heifers was organized and held in Mymensingh, Bangladesh. The meeting was hosted by the Faculty of Veterinary Science of the Bangladesh Agricultural University (BAU) from 6 to 10 February 2006. It was attended by six foreign experts and two local experts, and was supported by the technical officer of RAS/5/044. The experts from countries participating in RAS/5/044 gave presentations on the current state of cattle breeding in their countries and two experts working in industrialized countries within the region (New Zealand and Australia) informed the participants about the existing cattle breeding programmes in their respective countries and offered their perspectives on how similar approaches could be transferred to the Member States participating in RAS/5/044. All experts also made a field visit to a prominent dairy-producing region, to experience at first-hand some of the current programmes

  2. SNAP-tag technology mediates site specific conjugation of antibody fragments with a photosensitizer and improves target specific phototoxicity in tumor cells.

    Science.gov (United States)

    Hussain, Ahmad Fawzi; Kampmeier, Florian; von Felbert, Verena; Merk, Hans-F; Tur, Mehmet Kemal; Barth, Stefan

    2011-12-21

    Cancer cells can be killed by photosensitizing agents that induce toxic effects when exposed to nonhazardous light, but this also causes significant damage to surrounding healthy cells. The specificity of photodynamic therapy can be increased by conjugating photosensitizing agents to antibodies and antibody fragments that bind specifically to tumor cell antigens. However, standard conjugation reactions produce heterogeneous products whose targeting specificity and spectroscopic properties can be compromised. In this study, we used an antibody fragment (scFv-425) that binds to the epidermal growth factor receptor (EGFR) as a model to investigate the use of SNAP-tag fusions as an improved conjugation strategy. The scFv-425-SNAP-tag fusion protein allowed the specific conjugation of a chlorin e6 photosensitizer modified with O(6)-benzylguanine, generating a homogeneous product that was delivered specifically to EGFR(+) cancer cells and resulted in significant, tumor cell-specific cytotoxicity. The impact of our results on the development of photodynamic therapy is discussed.

  3. Reader-Centered Technical Writing

    Science.gov (United States)

    Narayanan, M.

    2012-12-01

    Technical writing is an essential part of professional communication and in recent years it has shifted from a genre-based approach. Formerly, technical writing primarily focused on generating templates of documents and sometimes it was creating or reproducing traditional forms with minor modifications and updates. Now, technical writing looks at the situations surrounding the need to write. This involves deep thinking about the goals and objectives of the project on hand. Furthermore, one observes that it is very important for any participatory process to have the full support of management. This support needs to be well understood and believed by employees. Professional writing may be very persuasive in some cases. When presented in the appropriate context, technical writing can persuade a company to improve work conditions ensuring employee safety and timely production. However, one must recognize that lot of professional writing still continues to make use of reports and instruction manuals. Normally, technical and professional writing addresses four aspects. Objective: The need for generating a given professionally written technical document and the goals the document is expected to achieve and accomplish. Clientele: The clientele who will utilize the technical document. This may include the people in the organization. This may also include "unintended readers." Customers: The population that may be affected by the content of the technical document generated. This includes the stakeholders who will be influenced. Environment: The background in which the document is created. Also, the nature of the situation that warranted the generation of the document. Swiss Psychologist Jean Piaget's view of Learning focuses on three aspects. The author likes to extend Jean Piaget's ideas to students, who are asked to prepare and submit Reader-Centered Technical Writing reports and exercises. Assimilation: Writers may benefit specifically, by assimilating a new object into

  4. TECHNICAL COORDINATION

    CERN Multimedia

    A. Ball and W. Zeuner

    2011-01-01

      Operational experience 2011 CMS is approaching the end of a very successful year of operation. Proton- proton running ended in the late afternoon of 30th October with a stunning 5.73 fb–1 delivered by LHC, of which CMS recorded 5.22 fb–1. During heavy-ion operation, which continues until 7th December, both the accelerator and the CMS detector have also performed very well. Despite the encouraging overall reliability of technical operation, several infrastructure failures which occurred since the last Bulletin are worthy of mention, with one leading for the first time to significant data-loss. On 10th July, a CERN-wide power failure brought down essentially all services including the magnet, due to an MCS setting being left in “manual” after the recent technical stop, but there was no significant damage and the detector was operational before the LHC, despite a slow and tortuous recovery (one of several indications this year that there is room for improve...

  5. Improving 1D Site Specific Velocity Profiles for the Kik-Net Network

    Science.gov (United States)

    Holt, James; Edwards, Benjamin; Pilz, Marco; Fäh, Donat; Rietbrock, Andreas

    2017-04-01

    Ground motion predication equations (GMPEs) form the cornerstone of modern seismic hazard assessments. When produced to a high standard they provide reliable estimates of ground motion/spectral acceleration for a given site and earthquake scenario. This information is crucial for engineers to optimise design and for regulators who enforce legal minimum safe design capacities. Classically, GMPEs were built upon the assumption that variability around the median model could be treated as aleatory. As understanding improved, it was noted that the propagation could be segregated into the response of the average path from the source and the response of the site. This is because the heterogeneity of the near-surface lithology is significantly different from that of the bulk path. It was then suggested that the semi-ergodic approach could be taken if the site response could be determined, moving uncertainty away from aleatory to epistemic. The determination of reliable site-specific response models is therefore becoming increasingly critical for ground motion models used in engineering practice. Today it is common practice to include proxies for site response within the scope of a GMPE, such as Vs30 or site classification, in an effort to reduce the overall uncertainty of the predication at a given site. However, these proxies are not always reliable enough to give confident ground motion estimates, due to the complexity of the near-surface. Other approaches of quantifying the response of the site include detailed numerical simulations (1/2/3D - linear, EQL, non-linear etc.). However, in order to be reliable, they require highly detailed and accurate velocity and, for non-linear analyses, material property models. It is possible to obtain this information through invasive methods, but is expensive, and not feasible for most projects. Here we propose an alternative method to derive reliable velocity profiles (and their uncertainty), calibrated using almost 20 years of

  6. Zone-specific logistic regression models improve classification of prostate cancer on multi-parametric MRI.

    Science.gov (United States)

    Dikaios, Nikolaos; Alkalbani, Jokha; Abd-Alazeez, Mohamed; Sidhu, Harbir Singh; Kirkham, Alex; Ahmed, Hashim U; Emberton, Mark; Freeman, Alex; Halligan, Steve; Taylor, Stuart; Atkinson, David; Punwani, Shonit

    2015-09-01

    To assess the interchangeability of zone-specific (peripheral-zone (PZ) and transition-zone (TZ)) multiparametric-MRI (mp-MRI) logistic-regression (LR) models for classification of prostate cancer. Two hundred and thirty-one patients (70 TZ training-cohort; 76 PZ training-cohort; 85 TZ temporal validation-cohort) underwent mp-MRI and transperineal-template-prostate-mapping biopsy. PZ and TZ uni/multi-variate mp-MRI LR-models for classification of significant cancer (any cancer-core-length (CCL) with Gleason > 3 + 3 or any grade with CCL ≥ 4 mm) were derived from the respective cohorts and validated within the same zone by leave-one-out analysis. Inter-zonal performance was tested by applying TZ models to the PZ training-cohort and vice-versa. Classification performance of TZ models for TZ cancer was further assessed in the TZ validation-cohort. ROC area-under-curve (ROC-AUC) analysis was used to compare models. The univariate parameters with the best classification performance were the normalised T2 signal (T2nSI) within the TZ (ROC-AUC = 0.77) and normalized early contrast-enhanced T1 signal (DCE-nSI) within the PZ (ROC-AUC = 0.79). Performance was not significantly improved by bi-variate/tri-variate modelling. PZ models that contained DCE-nSI performed poorly in classification of TZ cancer. The TZ model based solely on maximum-enhancement poorly classified PZ cancer. LR-models dependent on DCE-MRI parameters alone are not interchangable between prostatic zones; however, models based exclusively on T2 and/or ADC are more robust for inter-zonal application. • The ADC and T2-nSI of benign/cancer PZ are higher than benign/cancer TZ. • DCE parameters are significantly different between benign PZ and TZ, but not between cancerous PZ and TZ. • Diagnostic models containing contrast enhancement parameters have reduced performance when applied across zones.

  7. An Improved Abstract State Machine Based Choreography Specification and Execution Algorithm for Semantic Web Services

    OpenAIRE

    Mehdipour Ataee, Shahin; Bayram, Zeki

    2018-01-01

    We identify significant weaknesses in the original Abstract State Machine (ASM) based choreography algorithm of Web Service Modeling Ontology (WSMO), which make it impractical for use in semantic web service choreography engines. We present an improved algorithm which rectifies the weaknesses of the original algorithm, as well as a practical, fully functional choreography engine implementation in Flora-2 based on the improved algorithm. Our improvements to the choreography algorithm include (...

  8. Increased sequence diversity coverage improves detection of HIV-Specific T cell responses

    DEFF Research Database (Denmark)

    Frahm, N.; Kaufmann, D.E.; Yusim, K.

    2007-01-01

    The accurate identification of HIV-specific T cell responses is important for determining the relationship between immune response, viral control, and disease progression. HIV-specific immune responses are usually measured using peptide sets based on consensus sequences, which frequently miss res...

  9. OligoRAP - an Oligo Re-Annotation Pipeline to improve annotation and estimate target specificity

    NARCIS (Netherlands)

    Neerincx, P.B.T.; Rauwerda, H.; Nie, H.; Groenen, M.A.M.; Breit, T.M.; Leunissen, J.A.M.

    2009-01-01

    Background: High throughput gene expression studies using oligonucleotide microarrays depend on the specificity of each oligonucleotide (oligo or probe) for its target gene. However, target specific probes can only be designed when a reference genome of the species at hand were completely sequenced,

  10. A strategy to improve skills in pharmaceutical supply management in East Africa: the regional technical resource collaboration for pharmaceutical management

    Directory of Open Access Journals (Sweden)

    Minzi Omary

    2008-12-01

    Full Text Available Abstract Background International initiatives such as the Global Fund to Fight AIDS, Tuberculosis and Malaria, the President's Emergency Plan for AIDS Relief and the President's Malaria Initiative have significantly increased availability and access to medicines in some parts of the developing world. Despite this, however, skills remain limited on quantifying needs for medications and ordering, receiving and storing medications appropriately; recording medications inventories accurately; distributing medications for use appropriately; and advising patients on how to use medications appropriately. The Regional Technical Resource Collaboration for Pharmaceutical Management (RTRC has been established to help address the problem of skills shortage in pharmaceutical management in East Africa. Methods The initiative brings together academic institutions from four East African countries to participate in skills-building activities in pharmaceutical supply management. The initiative targeted the institutions' ability to conduct assessments of pharmaceutical supply management systems and to develop and implement effective skills-building programmes for pharmaceutical supply chain management. Results Over a two-year period, the RTRC succeeded in conducting assessments of pharmaceutical supply management systems and practices in Kenya, Rwanda, Tanzania and Uganda. In 2006, the RTRC participated in a materials-development workshop in Kampala, Uganda, and contributed to the development of comprehensive HIV/AIDS pharmaceutical management training materials; these materials are now widely available in all four countries. In Tanzania and Uganda the RTRC has been involved with the training of health care workers in HIV/AIDS pharmaceutical management. In Kenya, Tanzania and Uganda the RTRC has been conducting operations research to find solutions to their countries' skills-shortage problems. Some of the interventions tested include applying and evaluating the

  11. A strategy to improve skills in pharmaceutical supply management in East Africa: the regional technical resource collaboration for pharmaceutical management.

    Science.gov (United States)

    Matowe, Lloyd; Waako, Paul; Adome, Richard Odoi; Kibwage, Isaac; Minzi, Omary; Bienvenu, Emile

    2008-12-23

    International initiatives such as the Global Fund to Fight AIDS, Tuberculosis and Malaria, the President's Emergency Plan for AIDS Relief and the President's Malaria Initiative have significantly increased availability and access to medicines in some parts of the developing world. Despite this, however, skills remain limited on quantifying needs for medications and ordering, receiving and storing medications appropriately; recording medications inventories accurately; distributing medications for use appropriately; and advising patients on how to use medications appropriately. The Regional Technical Resource Collaboration for Pharmaceutical Management (RTRC) has been established to help address the problem of skills shortage in pharmaceutical management in East Africa. The initiative brings together academic institutions from four East African countries to participate in skills-building activities in pharmaceutical supply management. The initiative targeted the institutions' ability to conduct assessments of pharmaceutical supply management systems and to develop and implement effective skills-building programmes for pharmaceutical supply chain management. Over a two-year period, the RTRC succeeded in conducting assessments of pharmaceutical supply management systems and practices in Kenya, Rwanda, Tanzania and Uganda. In 2006, the RTRC participated in a materials-development workshop in Kampala, Uganda, and contributed to the development of comprehensive HIV/AIDS pharmaceutical management training materials; these materials are now widely available in all four countries. In Tanzania and Uganda the RTRC has been involved with the training of health care workers in HIV/AIDS pharmaceutical management. In Kenya, Tanzania and Uganda the RTRC has been conducting operations research to find solutions to their countries' skills-shortage problems. Some of the interventions tested include applying and evaluating the effectiveness of a novel skills-building approach for

  12. TECHNICAL COORDINATION

    CERN Multimedia

    A. Ball and W. Zeuner

    2010-01-01

    Overview Once again, the bulk of this article reviews the intense activity of a recently completed shutdown, which, although quite unforeseeable until a few weeks before it started, proved by its success that our often advertised capability to conduct major maintenance within a two month period is real. Although safely completed, on-time to remarkable precision, the activity was not without incident, and highlighted our dependence on many experienced, specialist teams and their precise choreography. Even after the yoke was safely closed, magnet re-commissioning and beampipe pumpdown showed new and thought-provoking behaviour. The struggle to maintain adequate technical resources will be a pre-occupation over the coming months, in parallel with the start of truly sustained operation, for which various procedures are still being put in place. Planning for future shutdowns must now become a high priority, with many working groups and task forces already in existence to prepare infrastructure improvements and to...

  13. Selectivity/Specificity Improvement Strategies in Surface-Enhanced Raman Spectroscopy Analysis

    Directory of Open Access Journals (Sweden)

    Feng Wang

    2017-11-01

    Full Text Available Surface-enhanced Raman spectroscopy (SERS is a powerful technique for the discrimination, identification, and potential quantification of certain compounds/organisms. However, its real application is challenging due to the multiple interference from the complicated detection matrix. Therefore, selective/specific detection is crucial for the real application of SERS technique. We summarize in this review five selective/specific detection techniques (chemical reaction, antibody, aptamer, molecularly imprinted polymers and microfluidics, which can be applied for the rapid and reliable selective/specific detection when coupled with SERS technique.

  14. Improving Depression Care for Adults With Serious Mental Illness in Underresourced Areas: Community Coalitions Versus Technical Support.

    Science.gov (United States)

    Castillo, Enrico G; Shaner, Roderick; Tang, Lingqi; Chung, Bowen; Jones, Felica; Whittington, Yolanda; Miranda, Jeanne; Wells, Kenneth B

    2018-02-01

    Community Partners in Care (CPIC) was a group-randomized study of two approaches to implementing expanded collaborative depression care: Community Engagement and Planning (CEP), a coalition approach, and Resources for Services (RS), a technical assistance approach. Collaborative care networks in both arms involved health care and other agencies in five service sectors. This study examined six- and 12-month outcomes for CPIC participants with serious mental illness. This secondary analysis focused on low-income CPIC participants from racial-ethnic minority groups with serious mental illness in underresourced Los Angeles communities (N=504). Serious mental illness was defined as self-reported severe depression (≥20 on the Patient Health Questionnaire-8) at baseline or a lifetime history of bipolar disorder or psychosis. Logistic and Poisson regression with multiple imputation and response weights, controlling for covariates, was used to model intervention effects. Among CPIC participants, 50% had serious mental illness. Among those with serious mental illness, CEP relative to RS reduced the likelihood of poor mental health-related quality of life (OR=.62, 95% CI=.41-.95) but not depression (primary outcomes); reduced the likelihood of having homelessness risk factors and behavioral health hospitalizations; increased the likelihood of mental wellness; reduced specialty mental health medication and counseling visits; and increased faith-based depression visits (each pmental health-related quality of life and some social outcomes for adults with serious mental illness, although no evidence was found for long-term effects in this subsample.

  15. Improved prediction models for PCC pavement performance-related specifications, volume I : final report.

    Science.gov (United States)

    2000-12-01

    The current performance-related specifications (PRS) methodology has been under development by the Federal : Highway Administration (FHWA) for several years and has now reached a level at which it can be implemented by : State highway agencies. PRS f...

  16. Detection of Two Types of Weed through Machine Vision System: Improving Site-Specific Spraying

    Directory of Open Access Journals (Sweden)

    S Sabzi

    2018-03-01

    Full Text Available Introduction With increase in world population, one of the approaches to provide food is using site-specific management system or so-called precision farming. In this management system, management of crop production inputs such as fertilizers, lime, herbicides, seed, etc. is done based on farm location features, with the aim of reducing waste, increasing revenues and maintaining environmental quality. Precision farming involves various aspects and is applicable on farm fields at all stages of tillage, planting, and harvesting. Today, in line with precision farming purposes, and to control weeds, pests, and diseases, all the efforts of specialists in precision farming is to reduce the amount of chemical substances in products. Although herbicides improve the quality and quantity of agricultural production, the possibility of applying inappropriately and unreasonably is very high. If the dose is too low, weed control is not performed correctly. Otherwise, If the dosage is too high, herbicides can be toxic for crops, can be transferred to soil and stay in it for a long time, and can penetrate to groundwater. By applying herbicides to variable rate, the potential for significant cost savings and reduced environmental damage to the products and environment will be possible. It is evident that in large-scale modern agriculture, individual management of each plant without using some advanced technologies is not possible. using machine vision systems is one of precision farming techniques to identify weeds. This study aimed to detect three plant such as Centaurea depressa M.B, Malvaneglecta and Potato plant using machine vision system. Materials and Methods In order to train algorithm of designed machine vision system, a platform that moved with the speed of 10.34 was used for shooting of Marfona potato fields. This platform was consisted of a chassis, camera (DFK23GM021,CMOS, 120 f/s, Made in Germany, and a processor system equipped with Matlab 2015

  17. Improving international relations conferences through virtual interactions : Embodying a multi-agent Z specification framework

    NARCIS (Netherlands)

    Okot-Uma, R.W.

    2009-01-01

    This study investigates virtual interactions in distributed collaboration, with the aim to improve international relations conferences through virtual interactions. This is done by addressing the problems and issues of operation, context and strategy that frequently affect international relations

  18. Conceptualisation of socio-technical integrated information technology solutions to improve incident reporting through Maslow's hierarchy of needs: a qualitative study of junior doctors.

    Science.gov (United States)

    Yee, Kwang Chien

    2007-01-01

    Medical errors are common, especially within the acute healthcare delivery. The identification of systemic factors associated with adverse events and the construction of models to improve the safety of the healthcare system seems straightforward, this process has been proven to be much more difficult in the realism of medical practice due to the failure of the incident reporting system to capture the essential information, especially from the perspective of junior doctors. The failure of incidence reporting system has been related to the lack of socio-technical consideration for both system designs and system implementations. The main reason of non-reporting can be conceptualised through the motivation psychology model: Maslow's hierarchy of needs; in order to achieve a change in the socio-cultural domain for incident reporting. This paper presents a qualitative research methodology approach to generate contextual-rich insights into the socio-cultural and technological factors of incident reporting among junior doctors. The research illuminates the guiding principles for future socio-technical integrated information communication technology designs and implementations. Using Maslow's hierarchy of needs as the conceptual framework, the guiding principles aim to design electronic incident reporting systems which will motivate junior doctors to participate in the process. This research paper aims to make a significant contribution to the fields of socio-technical systems and medical errors management. The design and implementation of the new incident reporting system has great potential to motivate junior doctors to change the culture of incident reporting and to work towards a safer future healthcare system.

  19. Pascagoula Harbor, Mississippi. Feasibility Report on Improvement of the Federal Deep-Draft Navigation Channel. Volume 2. Technical Appendices. Revision.

    Science.gov (United States)

    1985-03-01

    20636 Atlanta, GA 30320 D-1-2 " ..... .,.,°. . FOR NAVIGAT~flN IMPROVEMENTS PASCAGOULA HARBOR, MfI SSI S SIPP I CONGRESSIONAL MAILING L(ST MIS SISSI PP I...channel. With the onl,; existing ranges in each of the legs being behind an outbound vessel it ncssitats’-: , the pilot leaving the wheelhouse to walk

  20. Does Problem-Based Learning Improve Problem Solving Skills?--A Study among Business Undergraduates at Malaysian Premier Technical University

    Science.gov (United States)

    Kadir, Z. Abdul; Abdullah, N. H.; Anthony, E.; Salleh, B. Mohd; Kamarulzaman, R.

    2016-01-01

    Problem-based Learning (PBL) approach has been widely used in various disciplines since it is claimed to improve students' soft skills. However, empirical supports on the effect of PBL on problem solving skills have been lacking and anecdotal in nature. This study aimed to determine the effect of PBL approach on students' problem solving skills…

  1. Improved overall survival in head and neck cancer patients after specific therapy of distant metastases.

    Science.gov (United States)

    Schulz, Dominik; Wirth, Markus; Piontek, Guido; Knopf, Andreas; Straube, Christoph; Pigorsch, Steffi; Combs, Stephanie E; Pickhard, Anja

    2018-05-01

    While metastases directed therapy for oligometastatic disease is recommended in different cancer entities, the treatment of solitary metastases in head and neck squamous cell carcinoma (HNSCC) patients is not clearly defined. A retrospective analysis was performed on data from 143 HNSCC patients treated between 2001 and 2016 in a tertiary university hospital. Clinical factors and outcome were measured using the median survival of patients receiving metastases specific therapy in comparison with matched control patients. In 37 patients, distant metastases were treated specifically with either surgery and/or stereotactic ablative radiotherapy and had with 23.97 months a more than three times higher median survival than 10 untreated matched controls with potentially treatable distant metastases (7.07 months). Our retrospective analysis demonstrates a significant survival benefit for HNSCC patients who received a specific therapy regarding distant metastasis irrespective of localization as compared to a matched control cohort.

  2. Increased sequence diversity coverage improves detection of HIV-Specific T cell responses

    DEFF Research Database (Denmark)

    Frahm, N.; Kaufmann, D.E.; Yusim, K.

    2007-01-01

    assay, these "toggled" peptides detected HIV-specific CD4(+) and CD8(+) T cell responses of significantly higher breadth and magnitude than matched consensus peptides. The observed increases were explained by a closer match of the toggled peptides to the autologous viral sequence. Toggled peptides......The accurate identification of HIV-specific T cell responses is important for determining the relationship between immune response, viral control, and disease progression. HIV-specific immune responses are usually measured using peptide sets based on consensus sequences, which frequently miss...... responses to regions where test set and infecting virus differ. In this study, we report the design of a peptide test set with significantly increased coverage of HIV sequence diversity by including alternative amino acids at variable positions during the peptide synthesis step. In an IFN-gamma ELISpot...

  3. Improving Facial Emotion Recognition in Schizophrenia: a Controlled Study Comparing Specific and Attentional Focused Cognitive Remediation.

    Science.gov (United States)

    Gaudelus, Baptiste; Virgile, Jefferson; Geliot, Sabrina; Franck, Nicolas

    2016-01-01

    Cognitive impairments associated with schizophrenia are very frequent. They concern both neurocognition and social cognition, including facial emotion recognition. These impairments have a negative impact on the daily functioning, in particular the social and vocational rehabilitation of people with schizophrenia. Previous studies in this area clearly demonstrated the interest of cognitive remediation to improve neurocognitive and social cognitive functioning in schizophrenia. They also established clear links between facial emotion recognition skills and attentional processes. The present study compares the GAÏA s-face program (GAÏA arm), which focuses on facial emotion recognition processes, with the RECOS program (RECOS arm), a neurocognitive remediation therapy focusing on selective attention. Forty people with schizophrenia were randomly distributed between each study arm and assessed pre- (T1) and post- (T2) therapy. The single-blind assessment focused on facial emotion recognition (the main criteria), symptoms, social and subjective functioning, and neurocognitive and social cognitive performance. Both programs were conducted by nurses after a 3-day training session. The study showed a significant improvement in facial emotion recognition performance in both groups, with a significantly larger effect in the GAÏA arm. Symptoms and social functioning also improved in the GAÏA arm, and certain neurocognitive and social cognitive processes improved in both study arms. Further studies are recommended, with larger population samples and a follow-up assessing the long-term preservation of these improvements.

  4. System-Wide and Group-Specific Health Service Improvements: Cross-Sectional Survey of Outpatient Improvement Preferences and Associations with Demographic Characteristics.

    Science.gov (United States)

    Fradgley, Elizabeth A; Paul, Christine L; Bryant, Jamie; Zucca, Alison; Oldmeadow, Christopher

    2018-01-23

    Efficient patient-centred quality improvement requires an understanding of the system-wide areas of dissatisfaction along with evidence to identify the programs which can be strategically targeted according to specific patient characteristics and preferences. This cross-sectional study reports the proportion of chronic disease outpatients selecting 23 patient-centred improvement initiatives. Using univariate tests and multivariable logistic regressions, this multi-site study also identifies initiatives differentially selected by outpatients according to clinical and demographic characteristics. A total of 475 outpatients participated (49% response). Commonly selected initiatives included: reducing wait-times (22.3%); convenient appointment scheduling (16.0%); and receiving up-to-date treatment information (16.0%). Within univariate tests, preferences for information and service accessibility initiatives were not significantly associated with specific subgroups. However, seven initiatives were preferred according to age, gender, diagnosis status, and chronic disease type within multivariate models. For example, neurology outpatients were more likely to select assistance to manage psychological symptoms when compared to oncology outpatients (OR: 2.89). Study findings suggest that system-wide programs to enhance information provision are strategic approaches to improve experiences across patient characteristics. Furthermore, a few initiatives can be targeted to specific groups and emphasized the importance of detailed scoping analyses and tailored implementation plans when designing patient-centred quality improvement programs.

  5. System-Wide and Group-Specific Health Service Improvements: Cross-Sectional Survey of Outpatient Improvement Preferences and Associations with Demographic Characteristics

    Directory of Open Access Journals (Sweden)

    Elizabeth A. Fradgley

    2018-01-01

    Full Text Available Efficient patient-centred quality improvement requires an understanding of the system-wide areas of dissatisfaction along with evidence to identify the programs which can be strategically targeted according to specific patient characteristics and preferences. This cross-sectional study reports the proportion of chronic disease outpatients selecting 23 patient-centred improvement initiatives. Using univariate tests and multivariable logistic regressions, this multi-site study also identifies initiatives differentially selected by outpatients according to clinical and demographic characteristics. A total of 475 outpatients participated (49% response. Commonly selected initiatives included: reducing wait-times (22.3%; convenient appointment scheduling (16.0%; and receiving up-to-date treatment information (16.0%. Within univariate tests, preferences for information and service accessibility initiatives were not significantly associated with specific subgroups. However, seven initiatives were preferred according to age, gender, diagnosis status, and chronic disease type within multivariate models. For example, neurology outpatients were more likely to select assistance to manage psychological symptoms when compared to oncology outpatients (OR: 2.89. Study findings suggest that system-wide programs to enhance information provision are strategic approaches to improve experiences across patient characteristics. Furthermore, a few initiatives can be targeted to specific groups and emphasized the importance of detailed scoping analyses and tailored implementation plans when designing patient-centred quality improvement programs.

  6. RBMK nuclear reactors: Proposals for instrumentation and control improvements to enhanced safety and availability. IEC technical report of type 3. Working material

    International Nuclear Information System (INIS)

    1995-01-01

    The present material presents a CD+V draft report ''RBMK nuclear reactors: Proposals for instrumentation and control improvements to enhance safety and availability'' prepared by the Joint IEC/IAEA team during 1993-1995. Experience has demonstrated the need to improve the safety instrumentation of the RBMK type reactors using well proven modern technology. The working group identified the upgrades and changes of the highest priority based on the evaluation of the RBMK systems and the events where the instrumentation was found to be inadequate for safe operation. The subjects discussed in this document were not selected on a systematic basis but were selected by the IEC and IAEA experts as considered to be appropriate to the activities of the IEC and for which technical experience was available. The items identified therefore do not reflect any ranking of the safety issues or any priority or impact on safety of any of the measures were they to be implemented. Many important safety issued and areas where physical measures are required to improve safety have been omitted and indeed not even acknowledged in this document. The recommendations presented in the document differ from those normally produced by the IEC in the form of standards as they are of a transitory nature and some have already been overtaken by the continuing process of improvements to plant safety. Figs and tabs

  7. Online Speaking Strategy Assessment for Improving Speaking Ability in the Area of Language for Specific Purposes: The Case of Tourism

    Science.gov (United States)

    Phaiboonnugulkij, Malinee; Prapphal, Kanchana

    2013-01-01

    The purpose of this study was to compare the differences in strategies used in an online language for specific purposes (LSP) speaking test in tourism with two proficiency groups of students, and to investigate the strategies that should be used for low-proficiency students to improve their LSP speaking ability. The Web-based Speaking Test in…

  8. TLEMsafe: Improving safety and predictability of complex musculoskeletal surgery using a patient-specific navigation system

    NARCIS (Netherlands)

    van der Krogt, Marjolein; Carbone, Vincenzo; Fluit, René; Fluit, René; Kolk, Sjoerd; Koopman, Hubertus F.J.M.; Verdonschot, Nicolaas Jacobus Joseph

    2011-01-01

    TLEMsafe aims to develop a surgical navigation system based on patient-specific MR-based models, for training and preoperative planning of complex musculoskeletal surgery. Here we describe the research setup of TLEMsafe, which we will illustrate using the results of a clinical example.

  9. Specific respiratory warm-up improves rowing performance and exertional dyspnea.

    Science.gov (United States)

    Volianitis, S; McConnell, A K; Koutedakis, Y; Jones, D A

    2001-07-01

    The purpose of this study was a) to compare the effect of three different warm-up protocols upon rowing performance and perception of dyspnea, and b) to identify the functional significance of a respiratory warm-up. A group of well-trained club rowers (N = 14) performed a 6-min all-out rowing simulation (Concept II). We examined differences in mean power output and dyspnea measures (modified CR-Borg scale) under three different conditions: after a submaximal rowing warm-up (SWU), a specific rowing warm-up (RWU), and a specific rowing warm-up with the addition of a respiratory warm-up (RWUplus) protocol. Mean power output during the 6-min all-out rowing effort increased by 1.2% after the RWUplus compared with that obtained after the RWU (P < 0.05) which, in turn, was by 3.2% higher than the performance after the SWU (P < 0.01). Similarly, after the RWUplus, dyspnea was 0.6 +/- 0.1 (P < 0.05) units of the Borg scale lower compared with the dyspnea after the RWU and 0.8 +/- 0.2 (P < 0.05) units lower than the dyspnea after the SWU. These data suggest that a combination of a respiratory warm-up protocol together with a specific rowing warm-up is more effective than a specific rowing warm-up or a submaximal warm-up alone as a preparation for rowing performance.

  10. An improved microculture-hemolytic spot assay for the study of carrier-specific antibody responses.

    Science.gov (United States)

    Kotkes, P; Weisman, Z; Mozes, E; Bentwich, Z

    1984-11-30

    A microculture system based on limiting dilution and a hemolytic spot assay was adapted for study of the carrier-specific anti-hapten response in vitro. Spleen or lymph node cells from normal mice or mice immunized with NIP-ovalbumin (NIP-OVA) or NIP-human thyroglobulin (NIP-Tg) were cultured for 5 days by the microculture technique. The anti-hapten (anti-NIP) response was measured by assaying the supernatants of the microcultures in a hemolytic spot test with NIP coupled to sheep red blood cells. A micro-ELISA reader was adapted to read the degree of lysis in the spot assay which gives an objective quantitation of the degree of lysis and thus reduces the number of culture replicates. In vivo induced specific helper cells in mice immunized with the carrier protein, human thyroglobulin, as well as carrier-specific T cell factors, gave rise to carrier-specific anti-NIP responses. The microculture system may enhance the expression of T-cell helper function when suppressor cells or their precursors are present in the initial cell preparation.

  11. Use of GIS-based Site-specific Nitrogen Management for Improving Energy Efficiency

    Science.gov (United States)

    To our knowledge, geographical information system (GIS)-based site-specific nitrogen management (SSNM) techniques have not been used to assess agricultural energy costs and efficiency. This chapter uses SSNM case studies for corn (Zea mays L.) grown in Missouri and cotton (Gossypium hirsutum L.) gro...

  12. Assessing Students' Technical Skill Attainment

    Science.gov (United States)

    Jorgensen, Haley

    2010-01-01

    The Wisconsin Technical College System (WTCS) is working to comply with the Carl D. Perkins Career and Technical Education Improvement Act of 2006 (Perkins) to ensure that its graduates have mastered the technical skills needed by business and industry. The legislation requires that each state identify and approve program assessment strategies…

  13. Hypoxia positron emission tomography imaging: combining information on perfusion and tracer retention to improve hypoxia specificity

    DEFF Research Database (Denmark)

    Busk, Morten; Munk, Ole L; Jakobsen, Steen S

    2017-01-01

    BACKGROUND: Static positron emission tomography (PET) allows mapping of tumor hypoxia, but low resolution and slow tracer retention/clearance results in poor image contrast and the risk of missing areas where hypoxic cells and necrosis are intermixed. Fully dynamic PET may improve accuracy but scan...

  14. Improving Facial Emotion Recognition in Schizophrenia: a Controlled Study Comparing Specific and Attentional Focused Cognitive Remediation

    OpenAIRE

    Gaudelus, Baptiste; Virgile, Jefferson; Geliot, Sabrina; Franck, Nicolas

    2016-01-01

    Cognitive impairments associated with schizophrenia are very frequent. They concern both neurocognition and social cognition, including facial emotion recognition. These impairments have a negative impact on the daily functioning, in particular the social and vocational rehabilitation of people with schizophrenia. Previous studies in this area clearly demonstrated the interest of cognitive remediation to improve neurocognitive and social cognitive functioning in schizophrenia. They also estab...

  15. Hardware Reuse Improvement through the Domain Specific Language dHDL.

    OpenAIRE

    Sánchez Marcos, Miguel Ángel; López Vallejo, Marisa; Iglesias Fernandez, Carlos Angel

    2012-01-01

    The dHDL language has been defined to improve hardware design productivity. This is achieved through the definition of a better reuse interface (including parameters, attributes and macroports) and the creation of control structures that help the designer in the hardware generation process.

  16. Improving some cognitive functions, specifically executive functions in grade R learners

    Directory of Open Access Journals (Sweden)

    Stef Esterhuizen

    2014-07-01

    and output phases of the designed learning process, as well as the characteristics of their inhibitory control functions. A striking finding was the improvement noted in the children’s application of the following executive functions, namely working memory, cognitive flexibility and inhibitory control.

  17. Improved perception of communication and compliance with a revised, intensive care unit-specific bedside communication sheet.

    Science.gov (United States)

    Aponte-Patel, Linda; Sen, Anita

    2015-01-01

    Although many pediatric intensive care units (PICUs) use beside communication sheets (BCSs) to highlight daily goals, the optimal format is unknown. A site-specific BCS could improve both PICU communication and compliance completing the BCS. Via written survey, PICU staff at an academic children's hospital provided recommendations for improving and revising an existing BCS. Pre- and post-BCS revision, PICU staff were polled regarding PICU communication and BCS effectiveness, and daily compliance for completing the BCS was monitored. After implementation of the revised BCS, staff reporting "excellent" or "very good" day-to-day communication within the PICU increased from 57% to 77% (P = .02). Compliance for completing the BCS also increased significantly (75% vs 83%, P = .03). Introduction of a focused and concise BCS tailored to a specific PICU leads to improved perceptions of communication by PICU staff and increased compliance completing the daily BCS. © The Author(s) 2014.

  18. Improved technical efficiency and exogenous factors in transportation demand for energy: An application of structural time series analysis to South Korean data

    International Nuclear Information System (INIS)

    Sa'ad, Suleiman

    2010-01-01

    This paper stresses the importance of incorporating the effects of improved technical efficiency and exogenous factors when estimating energy demand functions. Using annual time series data for the period 1973-2007 in the STSM (structural time series model) developed by Harvey et al. the paper estimates price and income elasticities of demand for energy as well as the annual growth of the stochastic trend at the end of the estimation period. The results of the study reveal a long-run income elasticity of 1.37 and a price elasticity of -0.19. In addition, the underlying trend is generally stochastic and negatively sloping during the greater part of the estimation period. Finally, the estimated result from the structural time series is compared with the results from the Johansen Cointegration. These results suggest that income is the dominant factor in energy consumption. In addition, the coefficient of linear trend is negative, supporting the results from the STSM.

  19. [Obstetrical prognosis improvement in patients exposed in utero to diethylstilbestrol with specific care management].

    Science.gov (United States)

    Amour, M-C; Mokdad, A; Mayenga, J-M; Belaisch-Allart, J

    2004-11-01

    To define the interest of a specific care management of pregnancies in patients exposed in utero to diethylstilbestrol, with the intention of reducing the number of spontaneous miscarriage and prematurity. One hundred and three pregnancies in 49 patients exposed in utero to diethylstilbestrol were followed during a 4-year study, while establishing a specific care management of pregnancies in those women. Spontaneous miscarriage rate was 18.5%, among which 16.5% before 15 weeks of pregnancy and 2% after 15 weeks of pregnancy. Premature birth rate was 41.9%, among which 10.8% of great premature birth (before 32 weeks of pregnancy), 13.5% of moderate premature birth (between 32 and 36 weeks of pregnancy), and 17.6% of minor prematurity (after 36 weeks of pregnancy). The patients' average delivery term was 36 +/-3.6 weeks. As compared with the literature data, our miscarriage and prematurity rates are found to be lower. Our specific care management seems thus to be effective.

  20. Quantification of Cooperativity in Heterodimer-DNA Binding Improves the Accuracy of Binding Specificity Models*

    Science.gov (United States)

    Isakova, Alina; Berset, Yves; Hatzimanikatis, Vassily; Deplancke, Bart

    2016-01-01

    Many transcription factors (TFs) have the ability to cooperate on DNA elements as heterodimers. Despite the significance of TF heterodimerization for gene regulation, a quantitative understanding of cooperativity between various TF dimer partners and its impact on heterodimer DNA binding specificity models is still lacking. Here, we used a novel integrative approach, combining microfluidics-steered measurements of dimer-DNA assembly with mechanistic modeling of the implicated protein-protein-DNA interactions to quantitatively interrogate the cooperative DNA binding behavior of the adipogenic peroxisome proliferator-activated receptor γ (PPARγ):retinoid X receptor α (RXRα) heterodimer. Using the high throughput MITOMI (mechanically induced trapping of molecular interactions) platform, we derived equilibrium DNA binding data for PPARγ, RXRα, as well as the PPARγ:RXRα heterodimer to more than 300 target DNA sites and variants thereof. We then quantified cooperativity underlying heterodimer-DNA binding and derived an integrative heterodimer DNA binding constant. Using this cooperativity-inclusive constant, we were able to build a heterodimer-DNA binding specificity model that has superior predictive power than the one based on a regular one-site equilibrium. Our data further revealed that individual nucleotide substitutions within the target site affect the extent of cooperativity in PPARγ:RXRα-DNA binding. Our study therefore emphasizes the importance of assessing cooperativity when generating DNA binding specificity models for heterodimers. PMID:26912662

  1. Quantification of Cooperativity in Heterodimer-DNA Binding Improves the Accuracy of Binding Specificity Models.

    Science.gov (United States)

    Isakova, Alina; Berset, Yves; Hatzimanikatis, Vassily; Deplancke, Bart

    2016-05-06

    Many transcription factors (TFs) have the ability to cooperate on DNA elements as heterodimers. Despite the significance of TF heterodimerization for gene regulation, a quantitative understanding of cooperativity between various TF dimer partners and its impact on heterodimer DNA binding specificity models is still lacking. Here, we used a novel integrative approach, combining microfluidics-steered measurements of dimer-DNA assembly with mechanistic modeling of the implicated protein-protein-DNA interactions to quantitatively interrogate the cooperative DNA binding behavior of the adipogenic peroxisome proliferator-activated receptor γ (PPARγ):retinoid X receptor α (RXRα) heterodimer. Using the high throughput MITOMI (mechanically induced trapping of molecular interactions) platform, we derived equilibrium DNA binding data for PPARγ, RXRα, as well as the PPARγ:RXRα heterodimer to more than 300 target DNA sites and variants thereof. We then quantified cooperativity underlying heterodimer-DNA binding and derived an integrative heterodimer DNA binding constant. Using this cooperativity-inclusive constant, we were able to build a heterodimer-DNA binding specificity model that has superior predictive power than the one based on a regular one-site equilibrium. Our data further revealed that individual nucleotide substitutions within the target site affect the extent of cooperativity in PPARγ:RXRα-DNA binding. Our study therefore emphasizes the importance of assessing cooperativity when generating DNA binding specificity models for heterodimers. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

  2. Technical Study on Improvement of Endurance Capability of Limit Short-circuit Current of Charge Control SMART Meter

    Science.gov (United States)

    Li, W. W.; Du, Z. Z.; Yuan, R. m.; Xiong, D. Z.; Shi, E. W.; Lu, G. N.; Dai, Z. Y.; Chen, X. Q.; Jiang, Z. Y.; Lv, Y. G.

    2017-10-01

    Smart meter represents the development direction of energy-saving smart grid in the future. The load switch, one of the core parts of smart meter, should be of high reliability, safety and endurance capability of limit short-circuit current. For this reason, this paper discusses the quick simulation of relationship between attraction and counterforce of load switch without iteration, establishes dual response surface model of attraction and counterforce and optimizes the design scheme of load switch for charge control smart meter, thus increasing electromagnetic attraction and spring counterforce. In this way, this paper puts forward a method to improve the withstand capacity of limit short-circuit current.

  3. Advanced Lithium-ion Batteries with High Specific Energy and Improved Safety for Nasa's Missions

    Science.gov (United States)

    West, William; Smart, Marshall; Soler, Jess; Krause, Charlie; Hwang, Constanza; Bugga, Ratnakumar

    2012-01-01

    High Energy Materials ( Cathodes, anodes and high voltage and safe electrolyte are required to meet the needs of the future space missions. A. Cathodes: The layered layered composites of of Li2MnO3 and LiMO2 are promising Power capability of the materials, however requires further improvement. Suitable morphology is critical for good performance and high tap (packing) density. Surface coatings help in the interfacial kinetics and stability. B. Electrolytes: Small additions of Flame Retardant Additives improves flammability without affecting performance (Rate and cycle life). 1.0 M in EC+EMC+TPP was shown to have good performance against the high voltage cathode; Performance demonstrated in large capacity prototype MCMB- LiNiCoO2 Cells. Formulations with higher proportions are looking promising. Still requires further validation through abuse tests (e.g., on 18650 cells).

  4. Rhetoric and Reality of School Improvement in Chile. A Multiple Case Study of School Improvement Policy and External Technical Support Programmes for Municipal Primary Schools

    OpenAIRE

    Gonzalez Torres, A. F.

    2017-01-01

    Currently we are witnessing the expansion of performance-based reforms in education around the world, based on a global education reform agenda. In Chile, the policy framework for school improvement has changed because of modifications to the governance structure and the introduction of performance standards in the school system. This policy framework defines a performance-based accountability system according to students’ achievement in Chile’s national examination (SIMCE), and institutes ex...

  5. Brain Specificity of Diffuse Optical Imaging: Improvements from Superficial Signal Regression and Tomography

    OpenAIRE

    Gregg, Nicholas M.; White, Brian R.; Zeff, Benjamin W.; Berger, Andrew J.; Culver, Joseph P.

    2010-01-01

    Functional near infrared spectroscopy (fNIRS) is a portable monitor of cerebral hemodynamics with wide clinical potential. However, in fNIRS, the vascular signal from the brain is often obscured by vascular signals present in the scalp and skull. In this paper, we evaluate two methods for improving in vivo data from adult human subjects through the use of high-density diffuse optical tomography (DOT). First, we test whether we can extend superficial regression methods (which utilize the multi...

  6. Anisakis/Ascaris IgE ratio improves specificity for the diagnosis of Anisakis simplex sensitization in travellers and immigrants.

    Science.gov (United States)

    Carballeda-Sangiao, N; Rodríguez-Mahillo, A I; Puente, S; Gutiérrez, M T; Moneo, I; González-Muñoz, M

    2014-10-01

    Anisakis simplex is a fish parasite responsible for human infection and is able to induce IgE-mediated reactions with several clinical manifestations. Laboratory diagnosis of Anisakis allergy is based on the detection of specific IgE using parasite whole antigen. Unfortunately, these diagnostic tools detect cross-reactivities with other nematodes and micro-organisms leading to low specificity of the diagnostic tests. The aim of this retrospective study was to assess the diagnostic value of specific IgE to Anisakis for diagnosis of A. simplex-sensitization in native Spanish residents (IMM, n=766) and subjects coming from tropical and sub-tropical geographic areas (TRO, n=233). Since Ascaris is the human parasite most closely related to Anisakis, specific IgE to Ascaris was also determined to assess Anisakis cross-reaction with other nematodes and the diagnostic value of Anisakis/Ascaris IgE ratio for Anisakis allergy was examined. IMM and TRO groups showed similar specific IgE to Anisakis levels, while TRO had higher levels of specific IgE to Ascaris than IMM group (p=0.001). ROC curve analysis determined that an Anisakis specific IgE threshold of 0.71 kU/L yielded 93% and 82% specificities in IMM and TRO groups, respectively. A cut-off value ≥4.4 for Anisakis/Ascaris IgE ratio increased specificity to 95% for samples having IgE to Ascaris ≥0.35. In conclusion, the ratio of specific IgE to Anisakis and Ascaris improved remarkably the specificity and this parameter easily obtained from the commercially available system could be useful in the diagnosis of hypersensitivity to A. simplex. Copyright © 2014 Elsevier B.V. All rights reserved.

  7. Boosting BCG with inert spores improves immunogenicity and induces specific IL-17 responses in a murine model of bovine tuberculosis.

    Science.gov (United States)

    Garcia-Pelayo, M Carmen; Kaveh, Daryan A; Sibly, Laura; Webb, Paul R; Bull, Naomi C; Cutting, Simon M; Hogarth, Philip J

    2016-05-01

    Tuberculosis (TB) remains a global pandemic, in both animals and man, and novel vaccines are urgently required. Heterologous prime-boost of BCG represents a promising strategy for improved TB vaccines, with respiratory delivery the most efficacious to date. Such an approach may be an ideal vaccination strategy against bovine TB (bTB), but respiratory vaccination presents a technical challenge in cattle. Inert bacterial spores represent an attractive vaccine vehicle. Therefore we evaluated whether parenterally administered spores are efficacious when used as a BCG boost in a murine model of immunity against Mycobacterium bovis. Here we report the use of heat-killed, TB10.4 adsorbed, Bacillus subtilis spores delivered via subcutaneous injection to boost immunity primed by BCG. We demonstrate that this approach improves the immunogenicity of BCG. Interestingly, this associated with substantial boosting of IL-17 responses; considered to be important in protective immunity against TB. These data demonstrate that parenteral delivery of spores represents a promising vaccine vehicle for boosting BCG, and identifies potential for optimisation for use as a vaccine for bovine TB. Crown Copyright © 2016. Published by Elsevier Ltd. All rights reserved.

  8. Specific balance training included in an endurance-resistance exercise program improves postural balance in elderly patients undergoing haemodialysis.

    Science.gov (United States)

    Frih, Bechir; Mkacher, Wajdi; Jaafar, Hamdi; Frih, Ameur; Ben Salah, Zohra; El May, Mezry; Hammami, Mohamed

    2018-04-01

    The purpose of this study was to evaluate the effects of 6 months of specific balance training included in endurance-resistance program on postural balance in haemodialysis (HD) patients. Forty-nine male patients undergoing HD were randomly assigned to an intervention group (balance training included in an endurance-resistance training, n = 26) or a control group (resistance-endurance training only, n = 23). Postural control was assessed using six clinical tests; Timed Up and Go test, Tinetti Mobility Test, Berg Balance Scale, Unipodal Stance test, Mini-Balance Evaluation Systems Test and Activities Balance Confidence scale. All balance measures increased significantly after the period of rehabilitation training in the intervention group. Only the Timed Up and Go, Berg Balance Scale, Mini-Balance Evaluation Systems Test and Activities Balance Confidence scores were improved in the control group. The ranges of change in these tests were greater in the balance training group. In HD patients, specific balance training included in a usual endurance-resistance training program improves static and dynamic balance better than endurance-resistance training only. Implications for rehabilitation Rehabilitation using exercise in haemodialysis patients improved global mobility and functional abilities. Specific balance training included in usual endurance resistance training program could lead to improved static and dynamic balance.

  9. Advanced Direct-Drive Generator for Improved Availability of Oscillating Wave Surge Converter Power Generation Systems Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Englebretson, Steven [ABB Inc., Cary, NC (United States); Ouyang, Wen [ABB Inc., Cary, NC (United States); Tschida, Colin [ABB Inc., Cary, NC (United States); Carr, Joseph [ABB Inc., Cary, NC (United States); Ramanan, V.R. [ABB Inc., Cary, NC (United States); Johnson, Matthew [Texas A& M Univ., College Station, TX (United States); Gardner, Matthew [Texas A& M Univ., College Station, TX (United States); Toliyat, Hamid [Texas A& M Univ., College Station, TX (United States); Staby, Bill [Resolute Marine Energy, Inc., Boston, MA (United States); Chertok, Allan [Resolute Marine Energy, Inc., Boston, MA (United States); Hazra, Samir [ABB Inc., Cary, NC (United States); Bhattacharya, Subhashish [ABB Inc., Cary, NC (United States)

    2017-05-13

    This report summarizes the activities conducted under the DOE-EERE funded project DE-EE0006400, where ABB Inc. (ABB), in collaboration with Texas A&M’s Advanced Electric Machines & Power Electronics (EMPE) Lab and Resolute Marine Energy (RME) designed, derisked, developed, and demonstrated a novel magnetically geared electrical generator for direct-drive, low-speed, high torque MHK applications The project objective was to investigate a novel and compact direct-drive electric generator and its system aspects that would enable elimination of hydraulic components in the Power Take-Off (PTO) of a Marine and Hydrokinetic (MHK) system with an oscillating wave surge converter (OWSC), thereby improving the availability of the MHK system. The scope of this project was limited to the development and dry lab demonstration of a low speed generator to enable future direct drive MHK systems.

  10. A Improved Bone Graft Method For Upper Cervical Surgery with Posterior Approach: Technical Description and report of 52 cases.

    Science.gov (United States)

    Wang, Yongli; Wang, Xiangyang

    2018-02-21

    To report a minimum 12 months follow-up results of our improved bone graft method For upper cervica surgery with posterior approach. 52 consecutive patients which included odontoid nonunion in 33 patients, atlantoaxial instability in 11 patients and occipito-cervical deformity in 8 patients who underwent posterior C1-C2 transarticular screw /screw-rod internal fixation ( 41 cases )and occipitocervical fusion ( 11 cases ) with the improved bone graft technique. Each surgical procedure was performed by the same senior spine surgeon. We took lateral cervical standing roentgenograms before surgery, after surgery immediately and took craniocerebral computed tomography (CT) examination with reconstruction at 3, 6, 12, and 24 months, and annually thereafter. The postoperative follow-up time are about 12 month to 38 month. All cases showed satisfactory screw fixation by radiographic examination and there were no postoperative neurologic complications. 1 case had postoperative retropharyngeal infection after the transoral release and posterior reduction by pedicle screw instrumentation. All patients got solid fusions, and no pseudarthrosis occurred. All the cases had solid fusion at the 3-month follow-up. In conclusion, good bone graft bed, enough bone graft material, solid local fixation and effective bone graft method are a prerequisite for successful bone graft. By analysing the postoperative follow-up in the consecutive cases in this study, our new bone graft method which discribed a new bone graft structure is a reliable posterior fusion technique. It is worth to be concern and the further research is needed. Copyright © 2018. Published by Elsevier Inc.

  11. Imagining Technicities

    DEFF Research Database (Denmark)

    Liboriussen, Bjarke; Plesner, Ursula

    2011-01-01

    to the elements of taste and skill. In the final analysis those references were synthesized as five imagined technicities: the architect, the engineer, the client, the Chinese, and the Virtual World native. Because technicities are often assumed and rarely discussed as actants who influence practice, their role......, this article focuses on innovative uses of virtual worlds in architecture. We interviewed architects, industrial designers and other practitioners. Conceptually supported by an understanding of technicity found in Cultural Studies, the interviews were then coded with a focus on interviewees’ references...... in cooperation and development of ICTs seems to pass unnoticed. However, since they are aligned into ICTs, technicities impact innovation....

  12. Travel-time source-specific station correction improves location accuracy

    Science.gov (United States)

    Giuntini, Alessandra; Materni, Valerio; Chiappini, Stefano; Carluccio, Roberto; Console, Rodolfo; Chiappini, Massimo

    2013-04-01

    Accurate earthquake locations are crucial for investigating seismogenic processes, as well as for applications like verifying compliance to the Comprehensive Test Ban Treaty (CTBT). Earthquake location accuracy is related to the degree of knowledge about the 3-D structure of seismic wave velocity in the Earth. It is well known that modeling errors of calculated travel times may have the effect of shifting the computed epicenters far from the real locations by a distance even larger than the size of the statistical error ellipses, regardless of the accuracy in picking seismic phase arrivals. The consequences of large mislocations of seismic events in the context of the CTBT verification is particularly critical in order to trigger a possible On Site Inspection (OSI). In fact, the Treaty establishes that an OSI area cannot be larger than 1000 km2, and its larger linear dimension cannot be larger than 50 km. Moreover, depth accuracy is crucial for the application of the depth event screening criterion. In the present study, we develop a method of source-specific travel times corrections based on a set of well located events recorded by dense national seismic networks in seismically active regions. The applications concern seismic sequences recorded in Japan, Iran and Italy. We show that mislocations of the order of 10-20 km affecting the epicenters, as well as larger mislocations in hypocentral depths, calculated from a global seismic network and using the standard IASPEI91 travel times can be effectively removed by applying source-specific station corrections.

  13. Allergen-loaded strontium-doped hydroxyapatite spheres improve allergen-specific immunotherapy in mice.

    Science.gov (United States)

    Garbani, M; Xia, W; Rhyner, C; Prati, M; Scheynius, A; Malissen, B; Engqvist, H; Maurer, M; Crameri, R; Terhorst, D

    2017-04-01

    Immunomodulatory interventions play a key role in the treatment of infections and cancer as well as allergic diseases. Adjuvants such as micro- and nanoparticles are often added to immunomodulatory therapies to enhance the triggered immune response. Here, we report the immunological assessment of novel and economically manufactured microparticle adjuvants, namely strontium-doped hydroxyapatite porous spheres (SHAS), which we suggest for the use as adjuvant and carrier in allergen-specific immunotherapy (ASIT). Scanning electron microscopy revealed that the synthesis procedure developed for the production of SHAS results in a highly homogeneous population of spheres. Strontium-doped hydroxyapatite porous spheres bound and released proteins such as ovalbumin (OVA) or the major cat allergen Fel d 1. SHAS-OVA were taken up by human monocyte-derived dendritic cells (mdDCs) and murine DCs and did not have any necrotic or apoptotic effects even at high densities. In a murine model of ASIT for allergic asthmatic inflammation, we found that OVA released from subcutaneously injected SHAS-OVA led to a sustained stimulation of both CD4 + and CD8 + T cells. Allergen-specific immunotherapy with SHAS-OVA as compared to soluble OVA resulted in similar humoral responses but in a higher efficacy as assessed by symptom scoring. We conclude that SHAS may constitute a suitable carrier and adjuvant for ASIT with great potential due to its unique protein-binding properties. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  14. The Triform algorithm: improved sensitivity and specificity in ChIP-Seq peak finding

    Directory of Open Access Journals (Sweden)

    Kornacker Karl

    2012-07-01

    Full Text Available Abstract Background Chromatin immunoprecipitation combined with high-throughput sequencing (ChIP-Seq is the most frequently used method to identify the binding sites of transcription factors. Active binding sites can be seen as peaks in enrichment profiles when the sequencing reads are mapped to a reference genome. However, the profiles are normally noisy, making it challenging to identify all significantly enriched regions in a reliable way and with an acceptable false discovery rate. Results We present the Triform algorithm, an improved approach to automatic peak finding in ChIP-Seq enrichment profiles for transcription factors. The method uses model-free statistics to identify peak-like distributions of sequencing reads, taking advantage of improved peak definition in combination with known characteristics of ChIP-Seq data. Conclusions Triform outperforms several existing methods in the identification of representative peak profiles in curated benchmark data sets. We also show that Triform in many cases is able to identify peaks that are more consistent with biological function, compared with other methods. Finally, we show that Triform can be used to generate novel information on transcription factor binding in repeat regions, which represents a particular challenge in many ChIP-Seq experiments. The Triform algorithm has been implemented in R, and is available via http://tare.medisin.ntnu.no/triform.

  15. OSH technical reference manual

    Energy Technology Data Exchange (ETDEWEB)

    1993-11-01

    In an evaluation of the Department of Energy (DOE) Occupational Safety and Health programs for government-owned contractor-operated (GOCO) activities, the Department of Labor`s Occupational Safety and Health Administration (OSHA) recommended a technical information exchange program. The intent was to share written safety and health programs, plans, training manuals, and materials within the entire DOE community. The OSH Technical Reference (OTR) helps support the secretary`s response to the OSHA finding by providing a one-stop resource and referral for technical information that relates to safe operations and practice. It also serves as a technical information exchange tool to reference DOE-wide materials pertinent to specific safety topics and, with some modification, as a training aid. The OTR bridges the gap between general safety documents and very specific requirements documents. It is tailored to the DOE community and incorporates DOE field experience.

  16. Technical Note: Improved CT number stability across patient size using dual-energy CT virtual monoenergetic imaging

    Energy Technology Data Exchange (ETDEWEB)

    Michalak, Gregory; Grimes, Joshua; Fletcher, Joel; Yu, Lifeng; Leng, Shuai; McCollough, Cynthia, E-mail: mccollough.cynthia@mayo.edu [Department of Radiology, Mayo Clinic, Rochester, Minnesota 55905 (United States); Halaweish, Ahmed [Siemens Medical Solutions, Malvern, Pennsylvania 19355 (United States)

    2016-01-15

    Purpose: The purpose of this study was to evaluate, over a wide range of phantom sizes, CT number stability achieved using two techniques for generating dual-energy computed tomography (DECT) virtual monoenergetic images. Methods: Water phantoms ranging in lateral diameter from 15 to 50 cm and containing a CT number test object were scanned on a DSCT scanner using both single-energy (SE) and dual-energy (DE) techniques. The SE tube potentials were 70, 80, 90, 100, 110, 120, 130, 140, and 150 kV; the DE tube potential pairs were 80/140, 70/150Sn, 80/150Sn, 90/150Sn, and 100/150Sn kV (Sn denotes that the 150 kV beam was filtered with a 0.6 mm tin filter). Virtual monoenergetic images at energies ranging from 40 to 140 keV were produced from the DECT data using two algorithms, monoenergetic (mono) and monoenergetic plus (mono+). Particularly in large phantoms, water CT number errors and/or artifacts were observed; thus, datasets with water CT numbers outside ±10 HU or with noticeable artifacts were excluded from the study. CT numbers were measured to determine CT number stability across all phantom sizes. Results: Data exclusions were generally limited to cases when a SE or DE technique with a tube potential of less than 90 kV was used to scan a phantom larger than 30 cm. The 90/150Sn DE technique provided the most accurate water background over the large range of phantom sizes evaluated. Mono and mono+ provided equally improved CT number stability as a function of phantom size compared to SE; the average deviation in CT number was only 1.4% using 40 keV and 1.8% using 70 keV, while SE had an average deviation of 11.8%. Conclusions: The authors’ report demonstrates, across all phantom sizes, the improvement in CT number stability achieved with mono and mono+ relative to SE.

  17. Development of an improved species specific PCR test for detection of Haemophilus parasuis

    DEFF Research Database (Denmark)

    Angen, Øystein; Oliveira, Simone; Ahrens, Peter

    2007-01-01

    lower when tested on pure cultures of H. parasuis (5 CFU and 0.5 CFU/PCR reaction, respectively). Addition of 1.4 x 10(5) Escherichia coli to each PCR tube did not alter the sensitivity of the tests. No difference in sensitivity of the tests was observed when tested on purified DNA. On the other hand...... by Oliveira et al. [Oliveira, S., Galina, L., Pijoan, C., 2001. Development of a PCR test to diagnose Haemophilus parasuis infections. J. Vet. Diagn. Invest. 13, 495-501]. The sensitivity of the present PCR test was found to be slightly lower when applied on clinical samples from diseased pigs and 10-fold...... of H. parasuis in clinical samples, regardless of the presence of affiliated species and contaminating flora. As the two PCR tests differ in sensitivity and specificity, the use of both PCR tests for different purposes is a possibility....

  18. Improvements on a patient-specific dose estimation system in nuclear medicine examination

    International Nuclear Information System (INIS)

    Chuang, K. S.; Lu, J. C.; Lin, H. H.; Dong, S. L.; Yang, H. J.; Shih, C. T.; Lin, C. H.; Yao, W. J.; Ni, Y. C.; Jan, M. L.; Chang, S. J.

    2014-01-01

    The purpose of this paper is to develop a patient-specific dose estimation system in nuclear medicine examination. A dose deposition routine to store the deposited energy of the photons during their flights was embedded in the widely used SimSET Monte Carlo code and a user-friendly interface for reading PET and CT images was developed. Dose calculated on ORNL phantom was used to validate the accuracy of this system. The ratios of S value for 99m Tc, 18 F and 131 I computed by this system to those obtained with OLINDA for various organs were ranged from 0.93 to 1.18, which were comparable to that obtained from MCNPX2.6 code (0.88-1.22). Our system developed provides opportunity for tumor dose estimation which cannot be known from the MIRD. The radiation dose can provide useful information in the amount of radioisotopes to be administered in radioimmunotherapy. (authors)

  19. Improving specificity of Bordetella pertussis detection using a four target real-time PCR

    Science.gov (United States)

    Detemmerman, Liselot; Soetens, Oriane; Yusuf, Erlangga; Piérard, Denis

    2017-01-01

    The incidence of whooping cough, a contagious respiratory disease caused by Bordetella pertussis, is on the rise despite existing vaccination programmes. Similar, though usually milder, respiratory symptoms may be caused by other members of the Bordetella genus: B. parapertussis, B. holmesii, and B. bronchiseptica. Pertussis diagnosis is mostly done using PCR, but the use of multiple targets is necessary in order to differentiate the different Bordetella spp. with sufficient sensitivity and specificity. In this study we evaluate a multiplex PCR assay for the differentiation of B. pertussis from other Bordetella spp., using the targets IS481, IS1001, IS1002, and recA. Moreover, we retrospectively explore the epidemiology of Bordetella spp. infections in Belgium, using the aforementioned assay over a three-year period, from 2013 until 2015. PMID:28403204

  20. Technical improvement using ultra-slim gastroscopes for direct peroral cholangioscopy: analysis of the initial learning phase.

    Science.gov (United States)

    Weigt, Jochen; Kandulski, Arne; Malfertheiner, Peter

    2015-01-01

    Direct peroral cholangioscopy (POCS) is an emerging technique complementing endoscopic retrograde cholangiopancreatography (ERCP). Only few data about the learning process of this technique exist. The objective of this study is to investigate the learning process of POCS in a tertiary center. The study was a single center observational trial. All patients were investigated with standard ERCP directly prior to cholangioscopy. The bile ducts were intubated using the balloon anchor technique. The learning process was analyzed using linear regression and cumulative sum analysis. A total of 42 POCS were performed. Intubation was successful in 38/42 (90%). Reasons for failed intubation were small caliber bile ducts, duodenal diverticulum and papillary adenoma. Failed intubation occurred three times in the first half and only one time in the second half of investigations. The mean intubation time was 8.4 ± 4.9 min (1.6-23 min). The average intubation time changed over time (R(2) = -0.7) from 9.5 min in the first half investigations to 7.3 min in the second half procedures. Cumulative sum analysis revealed an initial learning process of nine investigations with significant variations in results followed by a steady improvement in the following investigations. Direct POCS is a useful tool for the investigation of biliary disease, which demands a short but recognizable initial learning phase even for experienced endoscopists. © 2014 Japanese Society of Hepato-Biliary-Pancreatic Surgery.

  1. Radioimmunoassay of the myelin basic protein in biological fluids, conditions improving sensitivity and specificity

    International Nuclear Information System (INIS)

    Delassalle, A.; Jacque, C.; Raoul, M.; Legrand, J.C.; Cesselin, F.; Drouet, J.

    1980-01-01

    The radioimmunoassay (RIA) for myelin basic protein (MBP) in biological fluids was reassessed in order to improve its sensitivity and eliminate some interferences. By using the pre-incubation technique and the charcoal-dextram-horse serum mixture for the separation step, the detection limit could be lowered to 200 pg/ml for cerebrospinal fluids (CSF), amniotic fluids (AF) and nervous tissue extracts and 600 pg/ml for sera. The RIA could be used directly on CSF, AF and nervous tissue extracts. Sera, however, had to be heated in citrate buffer at 100 0 C in order to discard interfering material. The present method is 10 to 20 times more sensitive than others previously published. Moreover, it can be applied to amniotic fluid. The biological fluids had to be promptly frozen to avoid degradation of MBP

  2. Fruit Fiber Consumption Specifically Improves Liver Health Status in Obese Subjects under Energy Restriction.

    Science.gov (United States)

    Cantero, Irene; Abete, Itziar; Monreal, J Ignacio; Martinez, J Alfredo; Zulet, M Angeles

    2017-06-28

    The prevalence of non-alcoholic-fatty-liver-disease (NAFLD) is associated with obesity, diabetes, and metabolic syndrome (MS). This study aimed to evaluate the influence of two energy-restricted diets on non-invasive markers and scores of liver damage in obese individuals with features of MS after six months of follow-up and to assess the role of fiber content in metabolic outcomes. Seventy obese individuals from the RESMENA (Reduction of Metabolic Syndrome in Navarra) study were evaluated at baseline and after six months of energy-restricted nutritional intervention (American Heart Association (AHA) and RESMENA dietary groups). Dietary records, anthropometrical data, body composition by dual energy X-ray absorptiometry (DXA), and routine laboratory measurements were analyzed by standardized methods. Regarding liver status, cytokeratin-18 fragments and several non-invasive scores of fatty liver were also assessed. The RESMENA strategy was a good and complementary alternative to AHA for the treatment of obesity-related comorbidities. Participants with higher insoluble fiber consumption (≥7.5 g/day) showed improvements in fatty liver index (FLI), hepatic steatosis index (HIS), and NAFLD liver fat score (NAFLD_LFS), while gamma-glutamyl transferase (GGT) and transaminases evidenced significant improvements as a result of fruit fiber consumption (≥8.8 g/day). Remarkably, a regression model evidenced a relationship between liver status and fiber from fruits. These results support the design of dietary patterns based on the consumption of insoluble fiber and fiber from fruits in the context of energy restriction for the management of obese patients suffering fatty liver disease.

  3. Improvement of AEP Predictions Using Diurnal CFD Modelling with Site-Specific Stability Weightings Provided from Mesoscale Simulation

    Science.gov (United States)

    Hristov, Y.; Oxley, G.; Žagar, M.

    2014-06-01

    The Bolund measurement campaign, performed by Danish Technical University (DTU) Wind Energy Department (also known as RISØ), provided significant insight into wind flow modeling over complex terrain. In the blind comparison study several modelling solutions were submitted with the vast majority being steady-state Computational Fluid Dynamics (CFD) approaches with two equation k-epsilon turbulence closure. This approach yielded the most accurate results, and was identified as the state-of-the-art tool for wind turbine generator (WTG) micro-siting. Based on the findings from Bolund, further comparison between CFD and field measurement data has been deemed essential in order to improve simulation accuracy for turbine load and long-term Annual Energy Production (AEP) estimations. Vestas Wind Systems A/S is a major WTG original equipment manufacturer (OEM) with an installed base of over 60GW in over 70 countries accounting for 19% of the global installed base. The Vestas Performance and Diagnostic Centre (VPDC) provides online live data to more than 47GW of these turbines allowing a comprehensive comparison between modelled and real-world energy production data. In previous studies, multiple sites have been simulated with a steady neutral CFD formulation for the atmospheric surface layer (ASL), and wind resource (RSF) files have been generated as a base for long-term AEP predictions showing significant improvement over predictions performed with the industry standard linear WAsP tool. In this study, further improvements to the wind resource file generation with CFD are examined using an unsteady diurnal cycle approach with a full atmospheric boundary layer (ABL) formulation, with the unique stratifications throughout the cycle weighted according to mesoscale simulated sectorwise stability frequencies.

  4. Application of radioimmunoassay in improving the reproductive management of smallholder dairy cattle. Results from an IAEA regional technical cooperation project in Africa

    International Nuclear Information System (INIS)

    2007-09-01

    Improvement of livestock production in the African region has been embarked on in many countries with support from their own resources as well as from external donors. Although artificial insemination (AI) has been applied for cattle breeding for many years in Africa as a means of accelerated genetic improvement of the indigenous stock, the overall productivity of this sector has continued to be low. Some of the factors that contribute to the poor output include inadequate management practices, poor nutrition, occurrence of reproductive disorders, systemic diseases and parasites. The International Atomic Energy Agency (IAEA) has taken a keen interest in supporting efforts to improve livestock production in Africa through national and regional technical cooperation projects. In the recent past, two successive regional projects were implemented under the framework of the African Regional Cooperative Agreement (AFRA) programme. The first was entitled Development and Field Evaluation of Animal Feed Supplementation Packages and had two main components: (a) the development and dissemination of cost-effective and sustainable feed supplementation packages which are based on locally available feed resources; and (b) establishment of the 'self-coating' Radioimmunoassay (RIA) technique for measuring progesterone in the milk and blood of ruminants. The second was entitled Increasing and Improving Milk and Meat Production and had the objectives of: (a) assessing and improving AI programmes for small-scale dairy farmers; (b) establishing sustainable early non-pregnancy diagnosis (N-PD) and related services based on RIA; and (c) harmonizing managerial and field practices within the region. Some of the issues, among others, which have been identified through the above projects as being responsible for low productivity of cattle in Africa include: (a) inadequate follow-up of offspring arising from AI (e.g. poor calf management leading to retarded growth or even death, and failure

  5. Racial differences in hypogonadal improvement and prostate-specific antigen levels in hypogonadal men treated with testosterone replacement therapy

    OpenAIRE

    Coward, Robert M.; Simhan, Jay; Carson III, Culley C.

    2010-01-01

    PURPOSE: To observe hypogonadal men undergoing testosterone replacement therapy (TRT) and assess racial differences in hypogonadal improvement and prostate-specific antigen (PSA) levels. MATERIALS AND METHODS: In a retrospective analysis, 75 hypogonadal men were followed for an average 34 months after initiating TRT. Total testosterone and PSA levels were assessed every 6 months, and patients diagnosed with prostatitis or prostate cancer during treatment were excluded. RESULTS: For 16 African...

  6. Can reading-specific training stimuli improve the effect of perceptual learning on peripheral reading speed?

    Science.gov (United States)

    Bernard, Jean-Baptiste; Arunkumar, Amit; Chung, Susana T L

    2012-08-01

    In a previous study, Chung, Legge, and Cheung (2004) showed that training using repeated presentation of trigrams (sequences of three random letters) resulted in an increase in the size of the visual span (number of letters recognized in a glance) and reading speed in the normal periphery. In this study, we asked whether we could optimize the benefit of trigram training on reading speed by using trigrams more specific to the reading task (i.e., trigrams frequently used in the English language) and presenting them according to their frequencies of occurrence in normal English usage and observers' performance. Averaged across seven observers, our training paradigm (4 days of training) increased the size of the visual span by 6.44 bits, with an accompanied 63.6% increase in the maximum reading speed, compared with the values before training. However, these benefits were not statistically different from those of Chung, Legge, and Cheung (2004) using a random-trigram training paradigm. Our findings confirm the possibility of increasing the size of the visual span and reading speed in the normal periphery with perceptual learning, and suggest that the benefits of training on letter recognition and maximum reading speed may not be linked to the types of letter strings presented during training. Copyright © 2012 Elsevier Ltd. All rights reserved.

  7. Stool cultures for Shigella spp: improved specificity by using MacConkey agar with xylose.

    Science.gov (United States)

    Altwegg, M; Buser, J; von Graevenitz, A

    1996-03-01

    A total of 678 stool specimens were cultured on four different agars: on xylose-lysine-desoxycholate agar (XLD), MacConkey agar (Mac), MacConkey agar supplemented with xylose (Mac-X), and Hektoen enteric agar (HE). Isolation rates for shigellae were 77% on HE, 86% on Mac and Mac-X, and 91% on XLD. The specificities of the media were 61% for Mac, 75% for HE, and 78% for XLD and Mac-X. After overnight incubation, Mac-X is much easier to read than XLD, which requires incubation for at least 22 hours. Based on these results and also on the practical aspect that incubation for 22-21 hours does not fit well in our schedule, we now use Mac-X whenever shigellae need to be looked for (i.e. mainly patients with recent travel to tropical countries). As compared to our previous procedure the workload in the laboratory could be reduced by about 20%.

  8. Code-specific learning rules improve action selection by populations of spiking neurons.

    Science.gov (United States)

    Friedrich, Johannes; Urbanczik, Robert; Senn, Walter

    2014-08-01

    Population coding is widely regarded as a key mechanism for achieving reliable behavioral decisions. We previously introduced reinforcement learning for population-based decision making by spiking neurons. Here we generalize population reinforcement learning to spike-based plasticity rules that take account of the postsynaptic neural code. We consider spike/no-spike, spike count and spike latency codes. The multi-valued and continuous-valued features in the postsynaptic code allow for a generalization of binary decision making to multi-valued decision making and continuous-valued action selection. We show that code-specific learning rules speed up learning both for the discrete classification and the continuous regression tasks. The suggested learning rules also speed up with increasing population size as opposed to standard reinforcement learning rules. Continuous action selection is further shown to explain realistic learning speeds in the Morris water maze. Finally, we introduce the concept of action perturbation as opposed to the classical weight- or node-perturbation as an exploration mechanism underlying reinforcement learning. Exploration in the action space greatly increases the speed of learning as compared to exploration in the neuron or weight space.

  9. Modeling Exon-Specific Bias Distribution Improves the Analysis of RNA-Seq Data.

    Directory of Open Access Journals (Sweden)

    Xuejun Liu

    Full Text Available RNA-seq technology has become an important tool for quantifying the gene and transcript expression in transcriptome study. The two major difficulties for the gene and transcript expression quantification are the read mapping ambiguity and the overdispersion of the read distribution along reference sequence. Many approaches have been proposed to deal with these difficulties. A number of existing methods use Poisson distribution to model the read counts and this easily splits the counts into the contributions from multiple transcripts. Meanwhile, various solutions were put forward to account for the overdispersion in the Poisson models. By checking the similarities among the variation patterns of read counts for individual genes, we found that the count variation is exon-specific and has the conserved pattern across the samples for each individual gene. We introduce Gamma-distributed latent variables to model the read sequencing preference for each exon. These variables are embedded to the rate parameter of a Poisson model to account for the overdispersion of read distribution. The model is tractable since the Gamma priors can be integrated out in the maximum likelihood estimation. We evaluate the proposed approach, PGseq, using four real datasets and one simulated dataset, and compare its performance with other popular methods. Results show that PGseq presents competitive performance compared to other alternatives in terms of accuracy in the gene and transcript expression calculation and in the downstream differential expression analysis. Especially, we show the advantage of our method in the analysis of low expression.

  10. Satellite Remote Sensing and the Hydroclimate: Two Specific Examples of Improved Knowledge and Applications

    Science.gov (United States)

    Shepherd, M.; Santanello, J. A., Jr.

    2017-12-01

    When Explorer 1 launched nearly 60 years ago, it helped usher in a golden age of scientific understanding of arguably the most important planet in our solar system. From its inception NASA and its partners were charged with leveraging the vantagepoint of space to advance knowledge outside and within Earth's atmosphere. Earth is a particularly complex natural system that is increasingly modified by human activities. The hydrological or water cycle is a critical circuit in the Earth system. Its complexity requires novel observations and simulation capability to fully understand it and predict changes. This talk will introduce some of the unique satellite-based observations used for hydroclimate studies. Two specific examples will be presented. The first example explores a relatively new thread of research examining the impact of soil moisture on landfalling and other types of tropical systems. Recent literature suggests that tropical cyclones or large rain-producing systems like the one that caused catastrophic flooding in Louisiana (2016) derive moisture from a "brown ocean" of wet soils or wetlands. The second example summarizes a decade of research on how urbanization has altered the precipitation and land surface hydrology components of the water cycle. With both cases, a multitude of satellite or model-based datesets will be summarized (e.g., TRMM, GPM, SMAP, NLDAS).

  11. Effective modern C++ 42 specific ways to improve your use of C++11 and C++14

    CERN Document Server

    Meyers, Scott

    2015-01-01

    At first glance, C++11 and C++14 are defined by the new features they introduce, e.g., auto type declarations, move semantics, lambda expressions, and concurrency support. Information on these features is easy to come by, but learning to apply them effectively (such that the resulting software is correct, efficient, maintainable, and portable) is more challenging. That’s the role of this book. It describes how to write effective software using C++11 and C++14, i.e., using modern C++. Topics include: * The pros and cons of uniform initialization, noexcept specifications, perfect forwarding, and smart pointer make functions. * The relationships among std::move, std::forward, rvalues references, and universal references. * The most effective forms of lambda capture. * How best practices in “old” C++ programming (i.e., C++98) require revision for modern C++. Effective Modern C++ follows the proven format of Scott Meyers’ earlier Effective books (Effective C++, More Effective C++, and Effective STL), but c...

  12. Surgical Technical Evidence Review for Elective Total Joint Replacement Conducted for the AHRQ Safety Program for Improving Surgical Care and Recovery

    Science.gov (United States)

    Siletz, Anaar E.; Singer, Emily S.; Faltermeier, Claire; Hu, Q. Lina; Ko, Clifford Y.; Golladay, Gregory J.; Kates, Stephen L.; Wick, Elizabeth C.; Maggard-Gibbons, Melinda

    2018-01-01

    Background: Use of enhanced recovery pathways (ERPs) can improve patient outcomes, yet national implementation of these pathways remains low. The Agency for Healthcare Research and Quality (AHRQ; funder), the American College of Surgeons, and the Johns Hopkins Medicine Armstrong Institute for Patent Safety and Quality have developed the Safety Program for Improving Surgical Care and Recovery—a national effort to catalyze implementation of practices to improve perioperative care and enhance recovery of surgical patients. This review synthesizes evidence that can be used to develop a protocol for elective total knee arthroplasty (TKA) and total hip arthroplasty (THA). Study Design: This review focuses on potential components of the protocol relevant to surgeons; anesthesia components are reported separately. Components were identified through review of existing pathways and from consultation with technical experts. For each, a structured review of MEDLINE identified systematic reviews, randomized trials, and observational studies that reported on these components in patients undergoing elective TKA/THA. This primary evidence review was combined with existing clinical guidelines in a narrative format. Results: Sixteen components were reviewed. Of the 10 preoperative components, most were focused on risk factor assessment including anemia, diabetes mellitus, tobacco use, obesity, nutrition, immune-modulating therapy, and opiates. Preoperative education, venous thromboembolism (VTE) prophylaxis, and bathing/Staphylococcus aureus decolonization were also included. The routine use of drains was the only intraoperative component evaluated. The 5 postoperative components included early mobilization, continuous passive motion, extended duration VTE prophylaxis, early oral alimentation, and discharge planning. Conclusion: This review synthesizes the evidence supporting potential surgical components of an ERP for elective TKA/THA. The AHRQ Safety Program for Improving

  13. Delayed rehabilitation with task-specific therapies improves forelimb function after a cervical spinal cord injury.

    Science.gov (United States)

    Dai, Haining; Macarthur, Linda; McAtee, Marietta; Hockenbury, Nicole; Das, Paramita; Bregman, Barbara S

    2011-01-01

    The effect of activity based therapies on restoring forelimb function in rats was evaluated when initiated one month after a cervical spinal cord injury. Adult rats received a unilateral over-hemisection of the spinal cord at C4/5, which interrupts the right side of the spinal cord and the dorsal columns bilaterally, resulting in severe impairments in forelimb function with greater impairment on the right side. One month after injury rats were housed in enriched housing and received daily training in reaching, gridwalk, and CatWalk. A subset of rats received rolipram for 10 days to promote axonal plasticity. Rats were tested weekly for six weeks for reaching, elevated gridwalk, CatWalk, and forelimb use during vertical exploration. Rats exposed to enriched housing and daily training significantly increased the number of left reaches and pellets grasped and eaten, reduced the number of right forelimb errors on the gridwalk, increased right forelimb use during vertical exploration, recovered more normal step cycles, and reduced their hindlimb base of support on the CatWalk compared to rats in standard cages without daily training. Delayed rehabilitation with enriched housing and daily forelimb training significantly improved skilled, sensorimotor, and automatic forelimb function together after cervical spinal cord injury.

  14. Efficient fdCas9 Synthetic Endonuclease with Improved Specificity for Precise Genome Engineering

    KAUST Repository

    Aouida, Mustapha

    2015-07-30

    The Cas9 endonuclease is used for genome editing applications in diverse eukaryotic species. A high frequency of off-target activity has been reported in many cell types, limiting its applications to genome engineering, especially in genomic medicine. Here, we generated a synthetic chimeric protein between the catalytic domain of the FokI endonuclease and the catalytically inactive Cas9 protein (fdCas9). A pair of guide RNAs (gRNAs) that bind to sense and antisense strands with a defined spacer sequence range can be used to form a catalytically active dimeric fdCas9 protein and generate double-strand breaks (DSBs) within the spacer sequence. Our data demonstrate an improved catalytic activity of the fdCas9 endonuclease, with a spacer range of 15–39 nucleotides, on surrogate reporters and genomic targets. Furthermore, we observed no detectable fdCas9 activity at known Cas9 off-target sites. Taken together, our data suggest that the fdCas9 endonuclease variant is a superior platform for genome editing applications in eukaryotic systems including mammalian cells.

  15. Use of Simple Neck Extension to Improve Guiding Catheter Accessibility in Tortuous Cervical Internal Carotid Artery for Endovascular Embolization of Intracranial Aneurysm: A Technical Note.

    Science.gov (United States)

    Takata, Megumu; Fukuda, Hitoshi; Kinosada, Masanori; Miyake, Kosuke; Murao, Kenichi

    2017-09-01

    In endovascular embolization of intracranial aneurysms, a tortuous cervical internal carotid artery can limit guiding catheter access to a sufficiently high position. Although intermediate distal access catheters can go beyond the tortuous segment of internal carotid arteries, they may increase the risk of procedure-related complications, require significantly complex technical procedures, and limit the use of adjunctive techniques. Using simple neck extension alone, we successfully improved guiding catheter access in 2 patients. Through a provocative test, we confirmed suitability of manual neck extension in 2 patients with severe posterior curvature of a tortuous internal carotid artery. Intraoperatively, we manually extended the neck and stretched the curvatures. We guided a 6F guiding catheter superiorly and performed coil embolization with an occlusion balloon catheter in 1 case and with the balloon-assisted neck remodeling technique in 1 case. Coil embolization was completed without any adverse events in both cases. The simple neck extension technique successfully improved accessibility of the guiding catheter. As the need for safe and highly skilled intervention increases, our technique may be useful because it can reduce procedure-related complications and allow balloon-assisted techniques. Copyright © 2017 Elsevier Inc. All rights reserved.

  16. Low Cost Chemical Feedstocks Using an Improved and Energy Efficient Natural Gas Liquid (NGL) Removal Process, Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, Howard, S.; Lu, Yingzhong

    2012-08-10

    The overall objective of this project is to develop a new low-cost and energy efficient Natural Gas Liquid (NGL) recovery process - through a combination of theoretical, bench-scale and pilot-scale testing - so that it could be offered to the natural gas industry for commercialization. The new process, known as the IROA process, is based on U.S. patent No. 6,553,784, which if commercialized, has the potential of achieving substantial energy savings compared to currently used cryogenic technology. When successfully developed, this technology will benefit the petrochemical industry, which uses NGL as feedstocks, and will also benefit other chemical industries that utilize gas-liquid separation and distillation under similar operating conditions. Specific goals and objectives of the overall program include: (i) collecting relevant physical property and Vapor Liquid Equilibrium (VLE) data for the design and evaluation of the new technology, (ii) solving critical R&D issues including the identification of suitable dehydration and NGL absorbing solvents, inhibiting corrosion, and specifying proper packing structure and materials, (iii) designing, construction and operation of bench and pilot-scale units to verify design performance, (iv) computer simulation of the process using commercial software simulation platforms such as Aspen-Plus and HYSYS, and (v) preparation of a commercialization plan and identification of industrial partners that are interested in utilizing the new technology. NGL is a collective term for C2+ hydrocarbons present in the natural gas. Historically, the commercial value of the separated NGL components has been greater than the thermal value of these liquids in the gas. The revenue derived from extracting NGLs is crucial to ensuring the overall profitability of the domestic natural gas production industry and therefore of ensuring a secure and reliable supply in the 48 contiguous states. However, rising natural gas prices have dramatically reduced

  17. Mirror Visual Feedback Training Improves Intermanual Transfer in a Sport-Specific Task: A Comparison between Different Skill Levels.

    Science.gov (United States)

    Steinberg, Fabian; Pixa, Nils Henrik; Doppelmayr, Michael

    2016-01-01

    Mirror training therapy is a promising tool to initiate neural plasticity and facilitate the recovery process of motor skills after diseases such as stroke or hemiparesis by improving the intermanual transfer of fine motor skills in healthy people as well as in patients. This study evaluated whether these augmented performance improvements by mirror visual feedback (MVF) could be used for learning a sport-specific skill and if the effects are modulated by skill level. A sample of 39 young, healthy, and experienced basketball and handball players and 41 novices performed a stationary basketball dribble task at a mirror box in a standing position and received either MVF or direct feedback. After four training days using only the right hand, performance of both hands improved from pre- to posttest measurements. Only the left hand (untrained) performance of the experienced participants receiving MVF was more pronounced than for the control group. This indicates that intermanual motor transfer can be improved by MVF in a sport-specific task. However, this effect cannot be generalized to motor learning per se since it is modulated by individuals' skill level, a factor that might be considered in mirror therapy research.

  18. The critical role of point defects in improving the specific capacitance of δ-MnO2 nanosheets

    Energy Technology Data Exchange (ETDEWEB)

    Gao, Peng; Metz, Peter; Hey, Trevyn; Gong, Yuxuan; Liu, Dawei; Edwards, Doreen D.; Howe, Jane Y.; Huang, Rong; Misture, Scott T.

    2017-02-23

    3D porous nanostructures built from 2D δ-MnO2 nanosheets are an environmentally friendly and industrially scalable class of supercapacitor electrode material. While both the electrochemistry and defects of this material have been studied, the role of defects in improving the energy storage density of these materials has not been addressed. In this work, δ-MnO2 nanosheet assemblies with 150 m2 g-1 specific surface area are prepared by exfoliation of crystalline KxMnO2 and subsequent reassembly. Equilibration at different pH introduces intentional Mn vacancies into the nanosheets, increasing pseudocapacitance to over 300 F g-1, reducing charge transfer resistance as low as 3 Ω, and providing a 50% improvement in cycling stability. X-ray absorption spectroscopy and high-energy X-ray scattering demonstrate a correlation between the defect content and the improved electrochemical performance. The results show that Mn vacancies provide ion intercalation sites which concurrently improve specific capacitance, charge transfer resistance and cycling stability.

  19. Mirror Visual Feedback Training Improves Intermanual Transfer in a Sport-Specific Task: A Comparison between Different Skill Levels

    Directory of Open Access Journals (Sweden)

    Fabian Steinberg

    2016-01-01

    Full Text Available Mirror training therapy is a promising tool to initiate neural plasticity and facilitate the recovery process of motor skills after diseases such as stroke or hemiparesis by improving the intermanual transfer of fine motor skills in healthy people as well as in patients. This study evaluated whether these augmented performance improvements by mirror visual feedback (MVF could be used for learning a sport-specific skill and if the effects are modulated by skill level. A sample of 39 young, healthy, and experienced basketball and handball players and 41 novices performed a stationary basketball dribble task at a mirror box in a standing position and received either MVF or direct feedback. After four training days using only the right hand, performance of both hands improved from pre- to posttest measurements. Only the left hand (untrained performance of the experienced participants receiving MVF was more pronounced than for the control group. This indicates that intermanual motor transfer can be improved by MVF in a sport-specific task. However, this effect cannot be generalized to motor learning per se since it is modulated by individuals’ skill level, a factor that might be considered in mirror therapy research.

  20. Unit-specific calibration of Actigraph accelerometers in a mechanical setup - is it worth the effort? The effect on random output variation caused by technical inter-instrument variability in the laboratory and in the field

    DEFF Research Database (Denmark)

    Moeller, Niels C; Korsholm, Lars; Kristensen, Peter L

    2008-01-01

    *min-1 vs. calibrated SDbetween units = 67 counts*min-1). However, the effect of applying the derived calibration to children's and adolescents' free living physical activity data did not alter the coefficient of variation (CV) (children: CVraw = 30.2% vs. CVcalibrated = 30.4%, adolescents: CVraw = 36...... accelerometers in a mechanical setup using four different settings varying in frequencies and/or amplitudes. Calibration effect was analysed by comparing raw and calibrated data after applying unit-specific calibration factors to data obtained during quality checks in a mechanical setup and to data collected...... conditions had no apparent effect on inter-instrument variability. In all probability, the effect of technical calibration was primarily attenuated in the field by other more dominant sources of variation. However, routine technical assessments are still very important for determining the acceleration...