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Sample records for targets cysteine string

  1. Quercetin targets cysteine string protein (CSPalpha and impairs synaptic transmission.

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    Fenglian Xu

    2010-06-01

    Full Text Available Cysteine string protein (CSPalpha is a synaptic vesicle protein that displays unique anti-neurodegenerative properties. CSPalpha is a member of the conserved J protein family, also called the Hsp40 (heat shock protein of 40 kDa protein family, whose importance in protein folding has been recognized for many years. Deletion of the CSPalpha in mice results in knockout mice that are normal for the first 2-3 weeks of life followed by an unexplained presynaptic neurodegeneration and premature death. How CSPalpha prevents neurodegeneration is currently not known. As a neuroprotective synaptic vesicle protein, CSPalpha represents a promising therapeutic target for the prevention of neurodegenerative disorders.Here, we demonstrate that the flavonoid quercetin promotes formation of stable CSPalpha-CSPalpha dimers and that quercetin-induced dimerization is dependent on the unique cysteine string region. Furthermore, in primary cultures of Lymnaea neurons, quercetin induction of CSPalpha dimers correlates with an inhibition of synapse formation and synaptic transmission suggesting that quercetin interfers with CSPalpha function. Quercetin's action on CSPalpha is concentration dependent and does not promote dimerization of other synaptic proteins or other J protein family members and reduces the assembly of CSPalpha:Hsc70 units (70kDa heat shock cognate protein.Quercetin is a plant derived flavonoid and popular nutritional supplement proposed to prevent memory loss and altitude sickness among other ailments, although its precise mechanism(s of action has been unclear. In view of the therapeutic promise of upregulation of CSPalpha and the undesired consequences of CSPalpha dysfunction, our data establish an essential proof of principle that pharmaceutical agents can selectively target the neuroprotective J protein CSPalpha.

  2. World-volumes and string target spaces

    International Nuclear Information System (INIS)

    Green, M.B.

    1996-01-01

    String duality suggests a fascinating juxtoposition of world-volume and target-space dynamics. This is particularly apparent in the D-brane description of stringy solitons that forms a major focus of this article (which is not intended to be a comprehensive review of this extensive and sophisticated subject). The article is divided into four sections: the oligarchy of string world-sheets; p-branes and world-volumes; world-sheets for world-volumes; boundary states. D-branes and space-time supersymmetry (orig.)

  3. Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles

    DEFF Research Database (Denmark)

    Serafimova, Iana M; Pufall, Miles A; Krishnan, Shyam

    2012-01-01

    Targeting noncatalytic cysteine residues with irreversible acrylamide-based inhibitors is a powerful approach for enhancing pharmacological potency and selectivity. Nevertheless, concerns about off-target modification motivate the development of reversible cysteine-targeting strategies. Here we...... of these electrophiles into a noncovalent kinase-recognition scaffold produced slowly dissociating, covalent inhibitors of the p90 ribosomal protein S6 kinase RSK2. A cocrystal structure revealed specific noncovalent interactions that stabilize the complex by positioning the electrophilic carbon near the targeted...

  4. Targeting cysteine proteases in trypanosomatid disease drug discovery.

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    Ferreira, Leonardo G; Andricopulo, Adriano D

    2017-12-01

    Chagas disease and human African trypanosomiasis are endemic conditions in Latin America and Africa, respectively, for which no effective and safe therapy is available. Efforts in drug discovery have focused on several enzymes from these protozoans, among which cysteine proteases have been validated as molecular targets for pharmacological intervention. These enzymes are expressed during the entire life cycle of trypanosomatid parasites and are essential to many biological processes, including infectivity to the human host. As a result of advances in the knowledge of the structural aspects of cysteine proteases and their role in disease physiopathology, inhibition of these enzymes by small molecules has been demonstrated to be a worthwhile approach to trypanosomatid drug research. This review provides an update on drug discovery strategies targeting the cysteine peptidases cruzain from Trypanosoma cruzi and rhodesain and cathepsin B from Trypanosoma brucei. Given that current chemotherapy for Chagas disease and human African trypanosomiasis has several drawbacks, cysteine proteases will continue to be actively pursued as valuable molecular targets in trypanosomatid disease drug discovery efforts. Copyright © 2017. Published by Elsevier Inc.

  5. Cysteine Protease Inhibitors as Chemotherapy: Lessons from a Parasite Target

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    Selzer, Paul M.; Pingel, Sabine; Hsieh, Ivy; Ugele, Bernhard; Chan, Victor J.; Engel, Juan C.; Bogyo, Matthew; Russell, David G.; Sakanari, Judy A.; McKerrow, James H.

    1999-09-01

    Papain family cysteine proteases are key factors in the pathogenesis of cancer invasion, arthritis, osteoporosis, and microbial infections. Targeting this enzyme family is therefore one strategy in the development of new chemotherapy for a number of diseases. Little is known, however, about the efficacy, selectivity, and safety of cysteine protease inhibitors in cell culture or in vivo. We now report that specific cysteine protease inhibitors kill Leishmania parasites in vitro, at concentrations that do not overtly affect mammalian host cells. Inhibition of Leishmania cysteine protease activity was accompanied by defects in the parasite's lysosome/endosome compartment resembling those seen in lysosomal storage diseases. Colocalization of anti-protease antibodies with biotinylated surface proteins and accumulation of undigested debris and protease in the flagellar pocket of treated parasites were consistent with a pathway of protease trafficking from flagellar pocket to the lysosome/endosome compartment. The inhibitors were sufficiently absorbed and stable in vivo to ameliorate the pathology associated with a mouse model of Leishmania infection.

  6. Automatic Attraction of Visual Attention by Supraletter Features of Former Target Strings

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    Søren eKyllingsbæk

    2014-11-01

    Full Text Available Observers were trained to search for a particular horizontal string of 3 capital letters presented among similar strings consisting of exactly the same letters in different orders. The training was followed by a test in which the observers searched for a new target that was identical to one of the former distractors. The new distractor set consisted of the remaining former distractors plus the former target. On each trial, three letter-strings were displayed, which included the target string with a probability of .5. In Experiment 1, the strings were centered at different locations on the circumference of an imaginary circle around the fixation point. The training phase of Experiment 2 was similar, but in the test phase of the experiment, the strings were located in a vertical array centered on fixation, and in target-present arrays, the target always appeared at fixation. In both experiments, performance (d’ degraded on trials in which former targets were present, suggesting that the former targets automatically drew processing resources away from the current targets. Apparently, the two experiments showed automatic attraction of visual attention by supraletter features of former target strings.

  7. Target space supergeometry of η and λ-deformed strings

    Energy Technology Data Exchange (ETDEWEB)

    Borsato, Riccardo; Wulff, Linus [Blackett Laboratory, Imperial College,London SW7 2AZ (United Kingdom)

    2016-10-10

    We study the integrable η and λ-deformations of supercoset string sigma models, the basic example being the deformation of the AdS{sub 5}×S{sup 5} superstring. We prove that the kappa symmetry variations for these models are of the standard Green-Schwarz form, and we determine the target space supergeometry by computing the superspace torsion. We check that the λ-deformation gives rise to a standard (generically type II*) supergravity background; for the η-model the requirement that the target space is a supergravity solution translates into a simple condition on the R-matrix which enters the definition of the deformation. We further construct all such non-abelian R-matrices of rank four which solve the homogeneous classical Yang-Baxter equation for the algebra so(2,4). We argue that most of the corresponding backgrounds are equivalent to sequences of non-commuting TsT-transformations, and verify this explicitly for some of the examples.

  8. Cysteine proteases: Modes of activation and future prospects as pharmacological targets

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    Sonia eVerma

    2016-04-01

    Full Text Available Proteolytic enzymes are crucial for a variety of biological processes in organisms ranging from lower (virus, bacteria and parasite to the higher organisms (mammals. Proteases cleave proteins into smaller fragments by catalyzing peptide bonds hydrolysis. Proteases are classified according to their catalytic site, and distributed into four major classes: cysteine proteases, serine proteases, aspartic proteases and metallo-proteases. This review will cover only cysteine proteases, papain family enzymes which are involved in multiple functions such as extracellular matrix turnover, antigen presentation, processing events, digestion, immune invasion, hemoglobin hydrolysis, parasite invasion, parasite egress and processing surface proteins. Therefore, they are promising drug targets for various diseases. For preventing unwanted digestion, cysteine proteases are synthesized as zymogens, and contain a pro-domain (regulatory and a mature domain (catalytic. The prodomain acts as an endogenous inhibitor of the mature enzyme. For activation of the mature enzyme, removal of the prodomain is necessary and achieved by different modes. The pro-mature domain interaction can be categorized as protein-protein interactions (PPIs and may be targeted in a range of diseases. Cysteine protease inhibitors are available that can block the active site but no such inhibitor available yet that can be targeted to block the pro-mature domain interactions and prevent it activation. This review specifically highlights the modes of activation (processing of papain family enzymes, which involve auto-activation, trans-activation and also clarifies the future aspects of targeting PPIs to prevent the activation of cysteine proteases.

  9. Automatic attraction of visual attention by supraletter features of former target strings

    DEFF Research Database (Denmark)

    Kyllingsbæk, Søren; Lommel, Sven Van; Bundesen, Claus

    2014-01-01

    , performance (d’) degraded on trials in which former targets were present, suggesting that the former targets automatically drew processing resources away from the current targets. Apparently, the two experiments showed automatic attraction of visual attention by supraletter features of former target strings....

  10. The selenazal drug ebselen potently inhibits indoleamine 2,3-dioxygenase by targeting enzyme cysteine residues.

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    Terentis, Andrew C; Freewan, Mohammed; Sempértegui Plaza, Tito S; Raftery, Mark J; Stocker, Roland; Thomas, Shane R

    2010-01-26

    The heme enzyme indoleamine 2,3-dioxygenase (IDO) plays an important immune regulatory role by catalyzing the oxidative degradation of l-tryptophan. Here we show that the selenezal drug ebselen is a potent IDO inhibitor. Exposure of human macrophages to ebselen inhibited IDO activity in a manner independent of changes in protein expression. Ebselen inhibited the activity of recombinant human IDO (rIDO) with an apparent inhibition constant of 94 +/- 17 nM. Optical and resonance Raman spectroscopy showed that ebselen altered the active site heme of rIDO by inducing a transition of the ferric heme iron from the predominantly high- to low-spin form and by lowering the vibrational frequency of the Fe-CO stretch of the CO complex, indicating an opening of the distal heme pocket. Substrate binding studies showed that ebselen enhanced nonproductive l-tryptophan binding, while circular dichroism indicated that the drug reduced the helical content and protein stability of rIDO. Thiol labeling and mass spectrometry revealed that ebselen reacted with multiple cysteine residues of IDO. Removal of cysteine-bound ebselen with dithiothreitol reversed the effects of the drug on the heme environment and significantly restored enzyme activity. These findings indicate that ebselen inhibits IDO activity by reacting with the enzyme's cysteine residues that result in changes to protein conformation and active site heme, leading to an increase in the level of nonproductive substrate binding. This study highlights that modification of cysteine residues is a novel and effective means of inhibiting IDO activity. It also suggests that IDO is under redox control and that the enzyme represents a previously unrecognized in vivo target of ebselen.

  11. Hyperbolic strings

    International Nuclear Information System (INIS)

    Popov, A.D.

    1991-01-01

    We introduce hyperbolic strings as closed bosonic strings with the target space R d-1,1 xT q+1,1 which has an additional time-like dimension in the internal space. The Fock spaces of the q-parametric family of standard bosonic, fermionic and heterotic strings with the target spaces of dimension n≤d+q are shown to be embedded into the Fock space of hyperbolic strings. The condition of the absence of anomaly fixes d and q for all three types of strings written in a bosonized form. (orig.)

  12. Cysteine 893 is a target of regulatory thiol modifications of GluA1 AMPA receptors.

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    Lotta von Ossowski

    Full Text Available Recent studies indicate that glutamatergic signaling involves, and is regulated by, thiol modifying and redox-active compounds. In this study, we examined the role of a reactive cysteine residue, Cys-893, in the cytosolic C-terminal tail of GluA1 AMPA receptor as a potential regulatory target. Elimination of the thiol function by substitution of serine for Cys-893 led to increased steady-state expression level and strongly reduced interaction with SAP97, a major cytosolic interaction partner of GluA1 C-terminus. Moreover, we found that of the three cysteine residues in GluA1 C-terminal tail, Cys-893 is the predominant target for S-nitrosylation induced by exogenous nitric oxide donors in cultured cells and lysates. Co-precipitation experiments provided evidence for native association of SAP97 with neuronal nitric oxide synthase (nNOS and for the potential coupling of Ca2+-permeable GluA1 receptors with nNOS via SAP97. Our results show that Cys-893 can serve as a molecular target for regulatory thiol modifications of GluA1 receptors, including the effects of nitric oxide.

  13. Cross-talk between malarial cysteine proteases and falstatin: the BC loop as a hot-spot target.

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    Srinivasan Sundararaj

    Full Text Available Cysteine proteases play a crucial role in the development of the human malaria parasites Plasmodium falciparum and Plasmodium vivax. Our earlier studies demonstrated that these enzymes are equipped with specific domains for defined functions and further suggested the mechanism of activation of cysteine proteases. The activities of these proteases are regulated by a new class of endogenous inhibitors of cysteine proteases (ICPs. Structural studies of the ICPs of Trypanosoma cruzi (chagasin and Plasmodium berghei (PbICP indicated that three loops (termed BC, DE, and FG are crucial for binding to target proteases. Falstatin, an ICP of P. falciparum, appears to play a crucial role in invasion of erythrocytes and hepatocytes. However, the mechanism of inhibition of cysteine proteases by falstatin has not been established. Our study suggests that falstatin is the first known ICP to function as a multimeric protein. Using site-directed mutagenesis, hemoglobin hydrolysis assays and peptide inhibition studies, we demonstrate that the BC loop, but not the DE or FG loops, inhibits cysteine proteases of P. falciparum and P. vivax via hydrogen bonds. These results suggest that the BC loop of falstatin acts as a hot-spot target for inhibiting malarial cysteine proteases. This finding suggests new strategies for the development of anti-malarial agents based on protease-inhibitor interactions.

  14. Phosphomimetic mutation of cysteine string protein-α increases the rate of regulated exocytosis by modulating fusion pore dynamics in PC12 cells.

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    Ning Chiang

    Full Text Available BACKGROUND: Cysteine string protein-α (CSPα is a chaperone to ensure protein folding. Loss of CSPα function associates with many neurological diseases. However, its function in modulating regulated exocytosis remains elusive. Although cspα-knockouts exhibit impaired synaptic transmission, overexpression of CSPα in neuroendocrine cells inhibits secretion. These seemingly conflicting results lead to a hypothesis that CSPα may undergo a modification that switches its function in regulating neurotransmitter and hormone secretion. Previous studies implied that CSPα undergoes phosphorylation at Ser10 that may influence exocytosis by altering fusion pore dynamics. However, direct evidence is missing up to date. METHODOLOGY/PRINCIPAL FINDINGS: Using amperometry, we investigated how phosphorylation at Ser10 of CSPα (CSPα-Ser10 modulates regulated exocytosis and if this modulation involves regulating a specific kinetic step of fusion pore dynamics. The real-time exocytosis of single vesicles was detected in PC12 cells overexpressing control vector, wild-type CSPα (WT, the CSPα phosphodeficient mutant (S10A, or the CSPα phosphomimetic mutants (S10D and S10E. The shapes of amperometric signals were used to distinguish the full-fusion events (i.e., prespike feet followed by spikes and the kiss-and-run events (i.e., square-shaped flickers. We found that the secretion rate was significantly increased in cells overexpressing S10D or S10E compared to WT or S10A. Further analysis showed that overexpression of S10D or S10E prolonged fusion pore lifetime compared to WT or S10A. The fraction of kiss-and-run events was significantly lower but the frequency of full-fusion events was higher in cells overexpressing S10D or S10E compared to WT or S10A. Advanced kinetic analysis suggests that overexpression of S10D or S10E may stabilize open fusion pores mainly by inhibiting them from closing. CONCLUSIONS/SIGNIFICANCE: CSPα may modulate fusion pore dynamics

  15. Targeting cysteine residues of human immunodeficiency virus type 1 protease by reactive free radical species.

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    Basu, A; Sehajpal, P K; Ogiste, J S; Lander, H M

    1999-01-01

    Nitric oxide (NO) is a naturally occurring free radical with many functions. The oxidized form of NO, the nitrosonium ion, reacts with the thiol group of cysteine residues resulting in their modification to S-nitrosothiols. The human immunodeficiency virus type 1 (HIV-1) protease (HIV-PR) has two cysteine residues that are conserved amongst different viral isolates found in patients with acquired immunodeficiency syndrome (AIDS). In an active dimer, these residues are located near the surface of the protease. We have found that treatment of HIV-PR with different NO congeners results in loss of its proteolytic activity and simultaneous formation of S-nitrosothiols. Sodium nitroprusside inhibited HIV-PR up to 70% and S-nitroso-N-acetylpenicillamine completely inhibited the protease within 5 min of treatment. The pattern of inhibition by NO donors is comparable to its inhibition by N-acetyl pepstatin. Using electrospray ionization-mass spectrometry, we identified the modification of HIV-PR by NO as that of S-nitrosation. Our findings point towards a possible role of NO in mediating resistance to HIV-1 infection.

  16. Target space interpretation of new module in 2D string theory

    International Nuclear Information System (INIS)

    Mahapatra, S.; Mukherji, S.; Sengupta, A.M.

    1992-01-01

    In this paper, the authors analyze the new states that have recently been discovered in 2D string theory by E. Witten and B. Zwiebach. Since the Liouville direction is uncompactified, the authors show that the deformations by the new ghost number two states generate equivalent classical solutions of the string fields. The authors argue that the new ghost number one states are responsible for generating transformations which relate such equivalent solutions. The authors also discuss the possible interpretation of higher ghost number states of these

  17. Synthetic siRNAs effectively target cystein protease 12 and α-actinin transcripts in Trichomonas vaginalis.

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    Ravaee, Roya; Ebadi, Parimah; Hatam, Gholamreza; Vafafar, Arghavan; Ghahramani Seno, Mohammad Mahdi

    2015-10-01

    The flagellated protozoan Trichomonas vaginalis (T. vaginalis) causes trichomoniasis, a reproductive tract infection, in humans. Trichomoniasis is the most common non-viral sexually transmitted disease worldwide. In addition to direct consequences such as infertility and abortion, there are indications that trichomoniasis favours development of prostate cancer and it has also been associated with increased risk of spreading human immunodeficiency virus and papillomavirus infections. Reports from around the world show that the rate of drug resistance in T. vaginalis is increasing, and therefore new therapeutic approaches have to be developed. Studying molecular biology of T. vaginalis will be quite helpful in identifying new drugable targets. RNAi is a powerful technique which allows biologist to specifically target gene products (i.e. mRNA) helping them in unravelling gene functions and biology of systems. However, due to lack of some parts of the required intrinsic RNAi machinery, the RNAi system is not functional in all orders of life. Here, by using synthetic siRNAs targeting two genes, i.e. α-actinin and cystein protease 12 (cp12), we demonstrate T. vaginalis cells are amenable to RNAi experiments conducted by extrinsic siRNAs. Electroporation of siRNAs targeting α-actinin or cp12 into T. vaginalis cells resulted in, respectively, 48-67% and 33-72% downregulation of the cognate transcripts compared to the T. vaginalis cells received siRNAs targeting GL2 luciferase as a control. This finding is helpful in that it demonstrates the potential of using extrinsically induced RNAi in studies on molecular biology of T. vaginalis such as those aiming at identifying new drug targets. Copyright © 2015 Elsevier Inc. All rights reserved.

  18. Cysteine Specific Targeting of the Functionally Distinct Peroxiredoxin and Glutaredoxin Proteins by the Investigational Disulfide BNP7787

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    Aulma R. Parker

    2015-03-01

    Full Text Available Glutaredoxin (Grx, peroxiredoxin (Prx, and thioredoxin (Trx are redoxin family proteins that catalyze different types of chemical reactions that impact cell growth and survival through functionally distinct intracellular pathways. Much research is focused on understanding the roles of these redoxin proteins in the development and/or progression of human diseases. Grx and Prx are overexpressed in human cancers, including human lung cancers. BNP7787 is a novel investigational agent that has been evaluated in previous clinical studies, including non-small cell lung cancer (NSCLC studies. Herein, data from activity assays, mass spectrometry analyses, and X-ray crystallographic studies indicate that BNP7787 forms mixed disulfides with select cysteine residues on Grx and Prx and modulates their function. Studies of interactions between BNP7787 and Trx have been conducted and reported separately. Despite the fact that Trx, Grx, and Prx are functionally distinct proteins that impact oxidative stress, cell proliferation and disease processes through different intracellular pathways, BNP7787 can modify each protein and appears to modulate function through mechanisms that are unique to each target protein. Tumor cells are often genomically heterogeneous containing subpopulations of cancer cells that often express different tumor-promoting proteins or that have multiple dysregulated signaling pathways modulating cell proliferation and drug resistance. A multi-targeted agent that simultaneously modulates activity of proteins important in mediating cell proliferation by functionally distinct intracellular pathways could have many potentially useful therapeutic applications.

  19. Embryonic demise caused by targeted disruption of a cysteine protease Dub-2.

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    Baek, Kwang-Hyun; Lee, Heyjin; Yang, Sunmee; Lim, Soo-Bin; Lee, Wonwoo; Lee, Jeoung Eun; Lim, Jung-Jin; Jun, Kisun; Lee, Dong-Ryul; Chung, Young

    2012-01-01

    A plethora of biological metabolisms are regulated by the mechanisms of ubiquitination, wherein this process is balanced with the action of deubiquitination system. Dub-2 is an IL-2-inducible, immediate-early gene that encodes a deubiquitinating enzyme with growth regulatory activity. DUB-2 presumably removes ubiquitin from ubiquitin-conjugated target proteins regulating ubiquitin-mediated proteolysis, but its specific target proteins are unknown yet. To elucidate the functional role of Dub-2, we generated genetically modified mice by introducing neo cassette into the second exon of Dub-2 and then homologous recombination was done to completely abrogate the activity of DUB-2 proteins. We generated Dub-2+/- heterozygous mice showing a normal phenotype and are fertile, whereas new born mouse of Dub-2-/- homozygous alleles could not survive. In addition, Dub-2-/- embryo could not be seen between E6.5 and E12.5 stages. Furthermore, the number of embryos showing normal embryonic development for further stages is decreased in heterozygotes. Even embryonic stem cells from inner cell mass of Dub-2-/- embryos could not be established. Our study suggests that the targeted disruption of Dub-2 may cause embryonic lethality during early gestation, possibly due to the failure of cell proliferation during hatching process.

  20. Embryonic demise caused by targeted disruption of a cysteine protease Dub-2.

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    Kwang-Hyun Baek

    Full Text Available BACKGROUND: A plethora of biological metabolisms are regulated by the mechanisms of ubiquitination, wherein this process is balanced with the action of deubiquitination system. Dub-2 is an IL-2-inducible, immediate-early gene that encodes a deubiquitinating enzyme with growth regulatory activity. DUB-2 presumably removes ubiquitin from ubiquitin-conjugated target proteins regulating ubiquitin-mediated proteolysis, but its specific target proteins are unknown yet. METHODOLOGY/PRINCIPAL FINDINGS: To elucidate the functional role of Dub-2, we generated genetically modified mice by introducing neo cassette into the second exon of Dub-2 and then homologous recombination was done to completely abrogate the activity of DUB-2 proteins. We generated Dub-2+/- heterozygous mice showing a normal phenotype and are fertile, whereas new born mouse of Dub-2-/- homozygous alleles could not survive. In addition, Dub-2-/- embryo could not be seen between E6.5 and E12.5 stages. Furthermore, the number of embryos showing normal embryonic development for further stages is decreased in heterozygotes. Even embryonic stem cells from inner cell mass of Dub-2-/- embryos could not be established. CONCLUSIONS: Our study suggests that the targeted disruption of Dub-2 may cause embryonic lethality during early gestation, possibly due to the failure of cell proliferation during hatching process.

  1. Hydrogen peroxide (H2O2) irreversibly inactivates creatine kinase from Pelodiscus sinensis by targeting the active site cysteine.

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    Wang, Wei; Lee, Jinhyuk; Hao, Hao; Park, Yong-Doo; Qian, Guo-Ying

    2017-12-01

    Creatine kinase (EC 2.7.3.2, CK) plays an important role in cellular energy metabolism and homeostasis by catalysing the transfer of phosphate between ATP and creatine phosphate. In this study, we investigated the effects of H 2 O 2 on PSCKM (muscle type creatine kinase from Pelodiscus sinensis) by the integrating method between enzyme kinetics and docking simulations. We found that H 2 O 2 strongly inactivated PSCKM (IC 50 =0.25mM) in a first-order kinetic process, and targeted the active site cysteine directly. A conformational study showed that H 2 O 2 did not induce the tertiary structural changes in PSCKM with no extensive exposure of hydrophobic surfaces. Sequential docking simulations between PSCKM and H 2 O 2 indicated that H 2 O 2 interacts with the ADP binding region of the active site, consistent with experimental results that demonstrated H 2 O 2 -induced inactivation. Our study demonstrates the effect of H 2 O 2 on PSCKM enzymatic function and unfolding, and provides important insight into the changes undergone by this central metabolic enzyme in ectothermic animals in response to the environment. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. Targeted Quantitation of Site-Specific Cysteine Oxidation in Endogenous Proteins Using a Differential Alkylation and Multiple Reaction Monitoring Mass Spectrometry Approach

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    Held, Jason M.; Danielson, Steven R.; Behring, Jessica B.; Atsriku, Christian; Britton, David J.; Puckett, Rachel L.; Schilling, Birgit; Campisi, Judith; Benz, Christopher C.; Gibson, Bradford W.

    2010-01-01

    Reactive oxygen species (ROS) are both physiological intermediates in cellular signaling and mediators of oxidative stress. The cysteine-specific redox-sensitivity of proteins can shed light on how ROS are regulated and function, but low sensitivity has limited quantification of the redox state of many fundamental cellular regulators in a cellular context. Here we describe a highly sensitive and reproducible oxidation analysis approach (OxMRM) that combines protein purification, differential alkylation with stable isotopes, and multiple reaction monitoring mass spectrometry that can be applied in a targeted manner to virtually any cysteine or protein. Using this approach, we quantified the site-specific cysteine oxidation status of endogenous p53 for the first time and found that Cys182 at the dimerization interface of the DNA binding domain is particularly susceptible to diamide oxidation intracellularly. OxMRM enables analysis of sulfinic and sulfonic acid oxidation levels, which we validate by assessing the oxidation of the catalytic Cys215 of protein tyrosine phosphatase-1B under numerous oxidant conditions. OxMRM also complements unbiased redox proteomics discovery studies as a verification tool through its high sensitivity, accuracy, precision, and throughput. PMID:20233844

  3. Atypical Thioredoxins in Poplar: The Glutathione-Dependent Thioredoxin-Like 2.1 Supports the Activity of Target Enzymes Possessing a Single Redox Active Cysteine1[W

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    Chibani, Kamel; Tarrago, Lionel; Gualberto, José Manuel; Wingsle, Gunnar; Rey, Pascal; Jacquot, Jean-Pierre; Rouhier, Nicolas

    2012-01-01

    Plant thioredoxins (Trxs) constitute a complex family of thiol oxidoreductases generally sharing a WCGPC active site sequence. Some recently identified plant Trxs (Clot, Trx-like1 and -2, Trx-lilium1, -2, and -3) display atypical active site sequences with altered residues between the two conserved cysteines. The transcript expression patterns, subcellular localizations, and biochemical properties of some representative poplar (Populus spp.) isoforms were investigated. Measurements of transcript levels for the 10 members in poplar organs indicate that most genes are constitutively expressed. Using transient expression of green fluorescent protein fusions, Clot and Trx-like1 were found to be mainly cytosolic, whereas Trx-like2.1 was located in plastids. All soluble recombinant proteins, except Clot, exhibited insulin reductase activity, although with variable efficiencies. Whereas Trx-like2.1 and Trx-lilium2.2 were efficiently regenerated both by NADPH-Trx reductase and glutathione, none of the proteins were reduced by the ferredoxin-Trx reductase. Only Trx-like2.1 supports the activity of plastidial thiol peroxidases and methionine sulfoxide reductases employing a single cysteine residue for catalysis and using a glutathione recycling system. The second active site cysteine of Trx-like2.1 is dispensable for this reaction, indicating that the protein possesses a glutaredoxin-like activity. Interestingly, the Trx-like2.1 active site replacement, from WCRKC to WCGPC, suppresses its capacity to use glutathione as a reductant but is sufficient to allow the regeneration of target proteins employing two cysteines for catalysis, indicating that the nature of the residues composing the active site sequence is crucial for substrate selectivity/recognition. This study provides another example of the cross talk existing between the glutathione/glutaredoxin and Trx-dependent pathways. PMID:22523226

  4. String theory

    International Nuclear Information System (INIS)

    Chan Hongmo.

    1987-10-01

    The paper traces the development of the String Theory, and was presented at Professor Sir Rudolf Peierls' 80sup(th) Birthday Symposium. The String theory is discussed with respect to the interaction of strings, the inclusion of both gauge theory and gravitation, inconsistencies in the theory, and the role of space-time. The physical principles underlying string theory are also outlined. (U.K.)

  5. Characterization of a Recombinant Cathepsin B-Like Cysteine Peptidase from Diaphorina citri Kuwayama (Hemiptera: Liviidae): A Putative Target for Control of Citrus Huanglongbing.

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    Ferrara, Taíse Fernanda da Silva; Schneider, Vanessa Karine; Kishi, Luciano Takeshi; Carmona, Adriana Karaoglanovic; Alves, Marcio Fernando Madureira; Belasque-Júnior, Jose; Rosa, José César; Hunter, Wayne Brian; Henrique-Silva, Flávio; Soares-Costa, Andrea

    2015-01-01

    Huanglonbing (HLB) is one of the most destructive disease affecting citrus plants. The causal agent is associated with the phloem-limited bacterium Candidatus Liberibacter asiaticus (CLas) and the psyllid Diaphorina citri, vector of disease, that transmits the bacterium associated with HLB. The control of disease can be achieved by suppressing either the bacterium or the vector. Among the control strategies for HLB disease, one of the widely used consists in controlling the enzymes of the disease vector, Diaphorina citri. The insect Diaphorina citri belongs to the order Hemiptera, which frequently have cysteine peptidases in the gut. The importance of this class of enzymes led us to search for enzymes in the D. citri transcriptome for the establishment of alternatives strategies for HLB control. In this study, we reported the identification and characterization of a cathepsin B-like cysteine peptidase from D. citri (DCcathB). DCcathB was recombinantly expressed in Pichia pastoris, presenting a molecular mass of approximately 50 kDa. The enzyme hydrolyzed the fluorogenic substrate Z-F-R-AMC (Km = 23.5 μM) and the selective substrate for cathepsin B, Z-R-R-AMC (Km = 6.13 μM). The recombinant enzyme was inhibited by the cysteine protease inhibitors E64 (IC50 = 0.014 μM) and CaneCPI-4 (Ki = 0.05 nM) and by the selective cathepsin B inhibitor CA-074 (IC50 = 0.095 nM). RT-qPCR analysis revealed that the expression of the DCcathB in nymph and adult was approximately 9-fold greater than in egg. Moreover, the expression of this enzyme in the gut was 175-fold and 3333-fold higher than in the remaining tissues and in the head, respectively, suggesting that DCcathB can be a target for HLB control.

  6. Characterization of a Recombinant Cathepsin B-Like Cysteine Peptidase from Diaphorina citri Kuwayama (Hemiptera: Liviidae: A Putative Target for Control of Citrus Huanglongbing.

    Directory of Open Access Journals (Sweden)

    Taíse Fernanda da Silva Ferrara

    Full Text Available Huanglonbing (HLB is one of the most destructive disease affecting citrus plants. The causal agent is associated with the phloem-limited bacterium Candidatus Liberibacter asiaticus (CLas and the psyllid Diaphorina citri, vector of disease, that transmits the bacterium associated with HLB. The control of disease can be achieved by suppressing either the bacterium or the vector. Among the control strategies for HLB disease, one of the widely used consists in controlling the enzymes of the disease vector, Diaphorina citri. The insect Diaphorina citri belongs to the order Hemiptera, which frequently have cysteine peptidases in the gut. The importance of this class of enzymes led us to search for enzymes in the D. citri transcriptome for the establishment of alternatives strategies for HLB control. In this study, we reported the identification and characterization of a cathepsin B-like cysteine peptidase from D. citri (DCcathB. DCcathB was recombinantly expressed in Pichia pastoris, presenting a molecular mass of approximately 50 kDa. The enzyme hydrolyzed the fluorogenic substrate Z-F-R-AMC (Km = 23.5 μM and the selective substrate for cathepsin B, Z-R-R-AMC (Km = 6.13 μM. The recombinant enzyme was inhibited by the cysteine protease inhibitors E64 (IC50 = 0.014 μM and CaneCPI-4 (Ki = 0.05 nM and by the selective cathepsin B inhibitor CA-074 (IC50 = 0.095 nM. RT-qPCR analysis revealed that the expression of the DCcathB in nymph and adult was approximately 9-fold greater than in egg. Moreover, the expression of this enzyme in the gut was 175-fold and 3333-fold higher than in the remaining tissues and in the head, respectively, suggesting that DCcathB can be a target for HLB control.

  7. Bowed Strings

    Science.gov (United States)

    Rossing, Thomas D.; Hanson, Roger J.

    In the next eight chapters, we consider some aspects of the science of bowed string instruments, old and new. In this chapter, we present a brief discussion of bowed strings, a subject that will be developed much more thoroughly in Chap. 16. Chapters 13-15 discuss the violin, the cello, and the double bass. Chapter 17 discusses viols and other historic string instruments, and Chap. 18 discusses the Hutchins-Schelleng violin octet.

  8. Bosonic strings

    CERN Document Server

    Jost, Jürgen

    2007-01-01

    This book presents a mathematical treatment of Bosonic string theory from the point of view of global geometry. As motivation, Jost presents the theory of point particles and Feynman path integrals. He provides detailed background material, including the geometry of Teichmüller space, the conformal and complex geometry of Riemann surfaces, and the subtleties of boundary regularity questions. The high point is the description of the partition function for Bosonic strings as a finite-dimensional integral over a moduli space of Riemann surfaces. Jost concludes with some topics related to open and closed strings and D-branes. Bosonic Strings is suitable for graduate students and researchers interested in the mathematics underlying string theory.

  9. Multiquark strings

    International Nuclear Information System (INIS)

    Wang, F.; Chun, W.

    1985-01-01

    The use of basis states described as hadronic (or hadron-hadron) or hidden-colour (or colour-colour) for a system of quarks does not necessarily imply that connected exotic multiquark hadrons do exist. Antisymmetrization of quark wave functions tends to make these descriptions ill defined. It appears necessary to have stable collective structures called strings or bags to provide the physical connections required by quark confinement. The masses of multiquark hadrons can then be estimated by using semplified string, bag and NR potential models. The results turn out to be qualitatively similar in all these models. The stability problem for multiquark strings is briefly discussed

  10. Architectures and representations for string transduction

    NARCIS (Netherlands)

    Chrupala, Grzegorz

    2015-01-01

    String transduction problems are ubiquitous in natural language processing: they include transliteration, grapheme-to-phoneme conversion, text normalization and translation. String transduction can be reduced to the simpler problems of sequence labeling by expressing the target string as a sequence

  11. Cosmic strings

    International Nuclear Information System (INIS)

    Bennett, D.P.

    1988-07-01

    Cosmic strings are linear topological defects that are predicted by some grand unified theories to form during a spontaneous symmetry breaking phase transition in the early universe. They are the basis for the only theories of galaxy formation aside from quantum fluctuations from inflation that are based on fundamental physics. In contrast to inflation, they can also be observed directly through gravitational lensing and their characteristic microwave background anistropy. It has recently been discovered by F. Bouchet and myself that details of cosmic string evolution are very different from the so-called ''standard model'' that has been assumed in most of the string induced galaxy formation calculations. Therefore, the details of galaxy formation in the cosmic string models are currently very uncertain. 29 refs., 9 figs

  12. Magnetic strings

    International Nuclear Information System (INIS)

    Chaves, Max

    2006-01-01

    The conception of the magnetic string is presented as an infinitely thin bundle of magnetic flux lines. The magnetic strings are surrounded by a film of current that rotates around them, and are a solution of Maxwell's equations. The magnetic potential contains a line singularity, and its stability can be established topologically. A few comments are added on the possibility that they may exist at a cosmological scale as relics of the Big Bang. (author) [es

  13. Lattice strings

    International Nuclear Information System (INIS)

    Thorn, C.B.

    1988-01-01

    The possibility of studying non-perturbative effects in string theory using a world sheet lattice is discussed. The light-cone lattice string model of Giles and Thorn is studied numerically to assess the accuracy of ''coarse lattice'' approximations. For free strings a 5 by 15 lattice seems sufficient to obtain better than 10% accuracy for the bosonic string tachyon mass squared. In addition a crude lattice model simulating string like interactions is studied to find out how easily a coarse lattice calculation can pick out effects such as bound states which would qualitatively alter the spectrum of the free theory. The role of the critical dimension in obtaining a finite continuum limit is discussed. Instead of the ''gaussian'' lattice model one could use one of the vertex models, whose continuum limit is the same as a gaussian model on a torus of any radius. Indeed, any critical 2 dimensional statistical system will have a stringy continuum limit in the absence of string interactions. 8 refs., 1 fig. , 9 tabs

  14. Investigating possible biological targets of Bj-CRP, the first cysteine-rich secretory protein (CRISP) isolated from Bothrops jararaca snake venom.

    Science.gov (United States)

    Lodovicho, Marina E; Costa, Tássia R; Bernardes, Carolina P; Menaldo, Danilo L; Zoccal, Karina F; Carone, Sante E; Rosa, José C; Pucca, Manuela B; Cerni, Felipe A; Arantes, Eliane C; Tytgat, Jan; Faccioli, Lúcia H; Pereira-Crott, Luciana S; Sampaio, Suely V

    2017-01-04

    Cysteine-rich secretory proteins (CRISPs) are commonly described as part of the protein content of snake venoms, nevertheless, so far, little is known about their biological targets and functions. Our study describes the isolation and characterization of Bj-CRP, the first CRISP isolated from Bothrops jararaca snake venom, also aiming at the identification of possible targets for its actions. Bj-CRP was purified using three chromatographic steps (Sephacryl S-200, Source 15Q and C18) and showed to be an acidic protein of 24.6kDa with high sequence identity to other snake venom CRISPs. This CRISP was devoid of proteolytic, hemorrhagic or coagulant activities, and it did not affect the currents from 13 voltage-gated potassium channel isoforms. Conversely, Bj-CRP induced inflammatory responses characterized by increase of leukocytes, mainly neutrophils, after 1 and 4h of its injection in the peritoneal cavity of mice, also stimulating the production of IL-6. Bj-CRP also acted on the human complement system, modulating some of the activation pathways and acting directly on important components (C3 and C4), thus inducing the generation of anaphylatoxins (C3a, C4a and C5a). Therefore, our results for Bj-CRP open up prospects for better understanding this class of toxins and its biological actions. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  15. Windings of twisted strings

    Science.gov (United States)

    Casali, Eduardo; Tourkine, Piotr

    2018-03-01

    Twistor string models have been known for more than a decade now but have come back under the spotlight recently with the advent of the scattering equation formalism which has greatly generalized the scope of these models. A striking ubiquitous feature of these models has always been that, contrary to usual string theory, they do not admit vibrational modes and thus describe only conventional field theory. In this paper we report on the surprising discovery of a whole new sector of one of these theories which we call "twisted strings," when spacetime has compact directions. We find that the spectrum is enhanced from a finite number of states to an infinite number of interacting higher spin massive states. We describe both bosonic and world sheet supersymmetric models, their spectra and scattering amplitudes. These models have distinctive features of both string and field theory, for example they are invariant under stringy T-duality but have the high energy behavior typical of field theory. Therefore they describe a new kind of field theories in target space, sitting on their own halfway between string and field theory.

  16. Yeast genes involved in regulating cysteine uptake affect production of hydrogen sulfide from cysteine during fermentation.

    Science.gov (United States)

    Huang, Chien-Wei; Walker, Michelle E; Fedrizzi, Bruno; Gardner, Richard C; Jiranek, Vladimir

    2017-08-01

    An early burst of hydrogen sulfide (H2S) produced by Saccharomyces cerevisiae during fermentation could increase varietal thiols and therefore enhance desirable tropical aromas in varieties such as Sauvignon Blanc. Here we attempted to identify genes affecting H2S formation from cysteine by screening yeast deletion libraries via a colony colour assay on media resembling grape juice. Both Δlst4 and Δlst7 formed lighter coloured colonies and produced significantly less H2S than the wild type on high concentrations of cysteine, likely because they are unable to take up cysteine efficiently. We then examined the nine known cysteine permeases and found that deletion of AGP1, GNP1 and MUP1 led to reduced production of H2S from cysteine. We further showed that deleting genes involved in the SPS-sensing pathway such as STP1 and DAL81 also reduced H2S from cysteine. Together, this study indirectly confirms that Agp1p, Gnp1p and Mup1p are the major cysteine permeases and that they are regulated by the SPS-sensing and target of rapamycin pathways under the grape juice-like, cysteine-supplemented, fermentation conditions. The findings highlight that cysteine transportation could be a limiting factor for yeast to generate H2S from cysteine, and therefore selecting wine yeasts without defects in cysteine uptake could maximise thiol production potential. © FEMS 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  17. Singleton strings

    International Nuclear Information System (INIS)

    Engquist, J.; Sundell, P.; Tamassia, L.

    2007-01-01

    The group theoretical structure underlying physics in anti de Sitter (AdS) spacetime is intrinsically different with respect to the flat case, due to the presence of special ultra-short representations, named singletons, that do not admit a flat space limit. The purpose of this collaboration is to exploit this feature in the study of string and brane dynamics in AdS spacetime, in particular while trying to establish a connection between String Theory in AdS backgrounds (in the tensionless limit) and Higher-Spin Gauge Theory. (orig.)

  18. String phenomenology

    CERN Document Server

    Ibáñez, Luis E

    2015-01-01

    This chapter reviews a number of topics in the field of string phenomenology, focusing on orientifold/F-theory models yielding semirealistic low-energy physics. The emphasis is on the extraction of the low-energy effective action and possible tests of specific models at the LHC.

  19. String GUTs

    International Nuclear Information System (INIS)

    Aldazabal, G.; Ibanez, L.E.; Uranga, A.M.

    1995-01-01

    Standard SUSY-GUTs such as those based on SU(5) or SO(10) lead to predictions for the values of α s and sin 2 θ W in amazing agreement with experiment. In this article we investigate how these models may be obtained from string theory, thus bringing them into the only known consistent framework for quantum gravity. String models with matter in standard GUT representations require the realization of affine Lie algebras at higher levels. We start by describing some methods to build level k=2 symmetric orbifold string models with gauge groups SU(5) or SO(10). We present several examples and identify generic features of the type of models constructed. Chiral fields appropriate to break the symmetry down to the standard model generically appear in the massless spectrum. However, unlike in standard SUSY-GUTs, they often behave as string moduli, i.e., they do not have self-couplings. We also discuss briefly the doublet-triplet Higgs splitting. We find that, in some models, built-in sliding-singlet type of couplings exist. (orig.)

  20. The haloarchaeal MCM proteins: bioinformatic analysis and targeted mutagenesis of the β7-β8 and β9-β10 hairpin loops and conserved zinc binding domain cysteines.

    Science.gov (United States)

    Kristensen, Tatjana P; Maria Cherian, Reeja; Gray, Fiona C; MacNeill, Stuart A

    2014-01-01

    The hexameric MCM complex is the catalytic core of the replicative helicase in eukaryotic and archaeal cells. Here we describe the first in vivo analysis of archaeal MCM protein structure and function relationships using the genetically tractable haloarchaeon Haloferax volcanii as a model system. Hfx. volcanii encodes a single MCM protein that is part of the previously identified core group of haloarchaeal MCM proteins. Three structural features of the N-terminal domain of the Hfx. volcanii MCM protein were targeted for mutagenesis: the β7-β8 and β9-β10 β-hairpin loops and putative zinc binding domain. Five strains carrying single point mutations in the β7-β8 β-hairpin loop were constructed, none of which displayed impaired cell growth under normal conditions or when treated with the DNA damaging agent mitomycin C. However, short sequence deletions within the β7-β8 β-hairpin were not tolerated and neither was replacement of the highly conserved residue glutamate 187 with alanine. Six strains carrying paired alanine substitutions within the β9-β10 β-hairpin loop were constructed, leading to the conclusion that no individual amino acid within that hairpin loop is absolutely required for MCM function, although one of the mutant strains displays greatly enhanced sensitivity to mitomycin C. Deletions of two or four amino acids from the β9-β10 β-hairpin were tolerated but mutants carrying larger deletions were inviable. Similarly, it was not possible to construct mutants in which any of the conserved zinc binding cysteines was replaced with alanine, underlining the likely importance of zinc binding for MCM function. The results of these studies demonstrate the feasibility of using Hfx. volcanii as a model system for reverse genetic analysis of archaeal MCM protein function and provide important confirmation of the in vivo importance of conserved structural features identified by previous bioinformatic, biochemical and structural studies.

  1. The haloarchaeal MCM proteins: bioinformatic analysis and targeted mutagenesis of the β7-β8 and β9-β10 hairpin loops and conserved zinc binding domain cysteines

    Directory of Open Access Journals (Sweden)

    Tatjana P Kristensen

    2014-03-01

    Full Text Available The hexameric MCM complex is the catalytic core of the replicative helicase in eukaryotic and archaeal cells. Here we describe the first in vivo analysis of archaeal MCM protein structure and function relationships using the genetically tractable haloarchaeon Haloferax volcanii as a model system. Hfx. volcanii encodes a single MCM protein that is part of the previously identified core group of haloarchaeal MCM proteins. Three structural features of the N-terminal domain of the Hfx. volcanii MCM protein were targeted for mutagenesis: the β7-β8 and β9-β10 β-hairpin loops and putative zinc binding domain. Five strains carrying single point mutations in the β7-β8 β-hairpin loop were constructed, none of which displayed impaired cell growth under normal conditions or when treated with the DNA damaging agent mitomycin C. However, short sequence deletions within the β7-β8 β-hairpin were not tolerated and neither was replacement of the highly conserved residue glutamate 187 with alanine. Six strains carrying paired alanine substitutions within the β9-β10 β-hairpin loop were constructed, leading to the conclusion that no individual amino acid within that hairpin loop is absolutely required for MCM function, although one of the mutant strains displays greatly enhanced sensitivity to mitomycin C. Deletions of two or four amino acids from the β9-β10 β-hairpin were tolerated but mutants carrying larger deletions were inviable. Similarly, it was not possible to construct mutants in which any of the conserved zinc binding cysteines was replaced with alanine, underlining the likely importance of zinc binding for MCM function. The results of these studies demonstrate the feasibility of using Hfx. volcanii as a model system for reverse genetic analysis of archaeal MCM protein function and provide important confirmation of the in vivo importance of conserved structural features identified by previous bioinformatic, biochemical and structural

  2. Structures of pseudechetoxin and pseudecin, two snake-venom cysteine-rich secretory proteins that target cyclic nucleotide-gated ion channels: implications for movement of the C-terminal cysteine-rich domain

    Energy Technology Data Exchange (ETDEWEB)

    Suzuki, Nobuhiro [Department of Applied Biochemistry, University of Tsukuba, Tsukuba, Ibaraki 305-8572 (Japan); Department of Biochemistry, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8602 (Japan); Yamazaki, Yasuo [Department of Biochemistry, Meiji Pharmaceutical University, Kiyose, Tokyo 204-8588 (Japan); Brown, R. Lane [Neurological Science Institute, Oregon Health and Science University, Beaverton, Oregon 97006 (United States); Fujimoto, Zui [Department of Biochemistry, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8602 (Japan); Morita, Takashi, E-mail: tmorita@my-pharm.ac.jp [Department of Biochemistry, Meiji Pharmaceutical University, Kiyose, Tokyo 204-8588 (Japan); Mizuno, Hiroshi, E-mail: tmorita@my-pharm.ac.jp [Department of Biochemistry, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8602 (Japan); VALWAY Technology Center, NEC Soft Ltd, Koto-ku, Tokyo 136-8627 (Japan); Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Central 6, Tsukuba, Ibaraki 305-8566 (Japan); Department of Applied Biochemistry, University of Tsukuba, Tsukuba, Ibaraki 305-8572 (Japan)

    2008-10-01

    The structures of pseudechetoxin and pseudecin suggest that both proteins bind to cyclic nucleotide-gated ion channels in a manner in which the concave surface occludes the pore entrance. Cyclic nucleotide-gated (CNG) ion channels play pivotal roles in sensory transduction by retinal photoreceptors and olfactory neurons. The elapid snake toxins pseudechetoxin (PsTx) and pseudecin (Pdc) are the only known protein blockers of CNG channels. These toxins belong to a cysteine-rich secretory protein (CRISP) family containing an N-terminal pathogenesis-related proteins of group 1 (PR-1) domain and a C-terminal cysteine-rich domain (CRD). PsTx and Pdc are highly homologous proteins, but their blocking affinities on CNG channels are different: PsTx blocks both the olfactory and retinal channels with ∼15–30-fold higher affinity than Pdc. To gain further insights into their structure and function, the crystal structures of PsTx, Pdc and Zn{sup 2+}-bound Pdc were determined. The structures revealed that most of the amino-acid-residue differences between PsTx and Pdc are located around the concave surface formed between the PR-1 domain and the CRD, suggesting that the concave surface is functionally important for CNG-channel binding and inhibition. A structural comparison in the presence and absence of Zn{sup 2+} ion demonstrated that the concave surface can open and close owing to movement of the CRD upon Zn{sup 2+} binding. The data suggest that PsTx and Pdc occlude the pore entrance and that the dynamic motion of the concave surface facilitates interaction with the CNG channels.

  3. Structures of pseudechetoxin and pseudecin, two snake-venom cysteine-rich secretory proteins that target cyclic nucleotide-gated ion channels: implications for movement of the C-terminal cysteine-rich domain

    International Nuclear Information System (INIS)

    Suzuki, Nobuhiro; Yamazaki, Yasuo; Brown, R. Lane; Fujimoto, Zui; Morita, Takashi; Mizuno, Hiroshi

    2008-01-01

    The structures of pseudechetoxin and pseudecin suggest that both proteins bind to cyclic nucleotide-gated ion channels in a manner in which the concave surface occludes the pore entrance. Cyclic nucleotide-gated (CNG) ion channels play pivotal roles in sensory transduction by retinal photoreceptors and olfactory neurons. The elapid snake toxins pseudechetoxin (PsTx) and pseudecin (Pdc) are the only known protein blockers of CNG channels. These toxins belong to a cysteine-rich secretory protein (CRISP) family containing an N-terminal pathogenesis-related proteins of group 1 (PR-1) domain and a C-terminal cysteine-rich domain (CRD). PsTx and Pdc are highly homologous proteins, but their blocking affinities on CNG channels are different: PsTx blocks both the olfactory and retinal channels with ∼15–30-fold higher affinity than Pdc. To gain further insights into their structure and function, the crystal structures of PsTx, Pdc and Zn 2+ -bound Pdc were determined. The structures revealed that most of the amino-acid-residue differences between PsTx and Pdc are located around the concave surface formed between the PR-1 domain and the CRD, suggesting that the concave surface is functionally important for CNG-channel binding and inhibition. A structural comparison in the presence and absence of Zn 2+ ion demonstrated that the concave surface can open and close owing to movement of the CRD upon Zn 2+ binding. The data suggest that PsTx and Pdc occlude the pore entrance and that the dynamic motion of the concave surface facilitates interaction with the CNG channels

  4. String Gas Cosmology

    OpenAIRE

    Brandenberger, Robert H.

    2008-01-01

    String gas cosmology is a string theory-based approach to early universe cosmology which is based on making use of robust features of string theory such as the existence of new states and new symmetries. A first goal of string gas cosmology is to understand how string theory can effect the earliest moments of cosmology before the effective field theory approach which underlies standard and inflationary cosmology becomes valid. String gas cosmology may also provide an alternative to the curren...

  5. Closed string field theory

    International Nuclear Information System (INIS)

    Strominger, A.

    1987-01-01

    A gauge invariant cubic action describing bosonic closed string field theory is constructed. The gauge symmetries include local spacetime diffeomorphisms. The conventional closed string spectrum and trilinear couplings are reproduced after spontaneous symmetry breaking. The action S is constructed from the usual ''open string'' field of ghost number minus one half. It is given by the associator of the string field product which is non-vanishing because of associativity anomalies. S does not describe open string propagation because open string states associate and can thereby be shifted away. A field theory of closed and open strings can be obtained by adding to S the cubic open string action. (orig.)

  6. Cosmic global strings

    International Nuclear Information System (INIS)

    Sikivie, P.

    1991-01-01

    The topics are: global strings; the gravitational field of a straight global string; how do global strings behave?; the axion cosmological energy density; computer simulations of the motion and decay of global strings; electromagnetic radiation from the conversion of Nambu-Goldstone bosons in astrophysical magnetic fields. (orig.)

  7. Evidence for string substructure

    International Nuclear Information System (INIS)

    Bergman, O.

    1996-06-01

    The author argues that the behavior of string theory at high temperature and high longitudinal boosts, combined with the emergence of p-branes as necessary ingredients in various string dualities, point to a possible reformulation of strings, as well as p-branes, as composites of bits. He reviews the string-bit models, and suggests generalizations to incorporate p-branes

  8. String driven inflation

    International Nuclear Information System (INIS)

    Turok, N.

    1987-11-01

    It is argued that, in fundamental string theories, as one traces the universe back in time a point is reached when the expansion rate is so fast that the rate of string creation due to quantum effects balances the dilution of the string density due to the expansion. One is therefore led into a phase of constant string density and an exponentially expanding universe. Fundamental strings therefore seem to lead naturally to inflation. 17 refs., 1 fig

  9. Hot String Soup

    OpenAIRE

    Lowe, D. A.; Thorlacius, L.

    1994-01-01

    Above the Hagedorn energy density closed fundamental strings form a long string phase. The dynamics of weakly interacting long strings is described by a simple Boltzmann equation which can be solved explicitly for equilibrium distributions. The average total number of long strings grows logarithmically with total energy in the microcanonical ensemble. This is consistent with calculations of the free single string density of states provided the thermodynamic limit is carefully defined. If the ...

  10. String-driven inflation

    International Nuclear Information System (INIS)

    Turok, N.

    1988-01-01

    It is argued that, in fundamental string theories, as one traces the universe back in time a point is reached when the expansion rate is so fast that the rate of string creation due to quantum effects balances the dilution of the string density due to the expansion. One is therefore led into a phase of constant string density and an exponentially expanding universe. Fundamental strings therefore seem to lead naturally to inflation

  11. Protein modification by acrolein: Formation and stability of cysteine adducts

    OpenAIRE

    Cai, Jian; Bhatnagar, Aruni; Pierce, William M.

    2009-01-01

    The toxicity of the ubiquitous pollutant and endogenous metabolite, acrolein, is due in part to covalent protein modifications. Acrolein reacts readily with protein nucleophiles via Michael addition and Schiff base formation. Potential acrolein targets in protein include the nucleophilic side chains of cysteine, histidine, and lysine residues as well as the free amino terminus of proteins. Although cysteine is the most acrolein-reactive residue, cysteine-acrolein adducts are difficult to iden...

  12. The heterotic string

    International Nuclear Information System (INIS)

    Gross, D.J.

    1986-01-01

    Traditional string theories, either bosonic or supersymmetric, came in two varieties, closed string theories and open string theories. Closed string are neutral objects which describe at low energies gravity or supergravity. Open strings have geometrically invariant ends to which charge can be attached, thereby obtaining, in addition to gravity, Yang-Mills gauge interactions. Recently a new kind of string theory was discovered--the heterotic string, which is a chiral hybrid of the closed superstring and the closed bosonic string, and which produces by an internal dynamical mechanism gauge interactions of a totally specified kind. Although this theory is found in an attempt to produce a superstring theory which would yield a low energy E/sub 8/xE/sub 8/ supersymmetric, anomaly free, gauge theory, as suggested by the anomaly cancellation mechanism of Green and Schwarz, it fits naturally into the general framework of consistent string theories

  13. Relativistic classical strings. II

    International Nuclear Information System (INIS)

    Galvao, C.A.P.

    1985-01-01

    The interactions of strings with electromagnetic and gravitational fields are extensively discussed. Some concepts of differential geometry are reviewed. Strings in Kaluza-Klein manifolds are studied. (L.C.) [pt

  14. Inflationary string theory?

    Indian Academy of Sciences (India)

    strongly motivate a detailed search for inflation within string theory, although it has ... between string theory and observations provides a strong incentive for ..... sonably be expected to arise for any system having very many degrees of freedom.

  15. π-Clamp-mediated cysteine conjugation

    Science.gov (United States)

    Zhang, Chi; Welborn, Matthew; Zhu, Tianyu; Yang, Nicole J.; Santos, Michael S.; van Voorhis, Troy; Pentelute, Bradley L.

    2016-02-01

    Site-selective functionalization of complex molecules is one of the most significant challenges in chemistry. Typically, protecting groups or catalysts must be used to enable the selective modification of one site among many that are similarly reactive, and general strategies that selectively tune the local chemical environment around a target site are rare. Here, we show a four-amino-acid sequence (Phe-Cys-Pro-Phe), which we call the ‘π-clamp’, that tunes the reactivity of its cysteine thiol for site-selective conjugation with perfluoroaromatic reagents. We use the π-clamp to selectively modify one cysteine site in proteins containing multiple endogenous cysteine residues. These examples include antibodies and cysteine-based enzymes that would be difficult to modify selectively using standard cysteine-based methods. Antibodies modified using the π-clamp retained binding affinity to their targets, enabling the synthesis of site-specific antibody-drug conjugates for selective killing of HER2-positive breast cancer cells. The π-clamp is an unexpected approach to mediate site-selective chemistry and provides new avenues to modify biomolecules for research and therapeutics.

  16. Strings in the Sun?

    International Nuclear Information System (INIS)

    Chudnovsky, E.; Vilenkin, A.

    1988-01-01

    If light superconducting strings were formed in the early Universe, then it is very likely that now they exist in abundance in the interstellar plasma and in stars. The dynamics of such strings can be dominated by friction, so that they are ''frozen'' into the plasma. Turbulence of the plasma twists and stretches the strings, forming a stochastic string network. Such networks must generate particles and magnetic fields, and may play an important role in the physics of stars and of the Galaxy

  17. Why string theory?

    CERN Document Server

    Conlon, Joseph

    2016-01-01

    Is string theory a fraud or one of the great scientific advances? Why do so many physicists work on string theory if it cannot be tested? This book provides insight into why such a theory, with little direct experimental support, plays such a prominent role in theoretical physics. The book gives a modern and accurate account of string theory and science, explaining what string theory is, why it is regarded as so promising, and why it is hard to test.

  18. First quantized noncritical relativistic Polyakov string

    International Nuclear Information System (INIS)

    Jaskolski, Z.; Meissner, K.A.

    1994-01-01

    The first quantization of the relativistic Brink-DiVecchia-Howe-Polyakov (BDHP) string in the range 1 < d 25 is considered. It is shown that using the Polyakov sum over bordered surfaces in the Feynman path integral quantization scheme one gets a consistent quantum mechanics of relativistic 1-dim extended objects in the range 1 < d < 25. In particular, the BDHP string propagator is exactly calculated for arbitrary initial and final string configurations and the Hilbert space of physical states of noncritical BDHP string is explicitly constructed. The resulting theory is equivalent to the Fairlie-Chodos-Thorn massive string model. In contrast to the conventional conformal field theory approach to noncritical string and random surfaces in the Euclidean target space the path integral formulation of the Fairlie-Chodos-Thorn string obtained in this paper does not rely on the principle of conformal invariance. Some consequences of this feature for constructing a consistent relativistic string theory based on the ''splitting-joining'' interaction are discussed. (author). 42 refs, 1 fig

  19. Introduction to string theory and string compactifications

    International Nuclear Information System (INIS)

    GarcIa-Compean, Hugo

    2005-01-01

    Basics of some topics on perturbative and non-perturbative string theory are reviewed. After a mathematical survey of the Standard Model of particle physics and GUTs, the bosonic string kinematics for the free case and with interaction is described. The effective action of the bosonic string and the spectrum is also discussed. T-duality in closed and open strings and the definition of D-brane are surveyed. Five perturbative superstring theories and their spectra is briefly outlined. Calabi-Yau three-fold compactifications of heterotic strings and their relation to some four-dimensional physics are given. Finally, non-perturbative issues like S-duality, M-theory and F-theory are also reviewed

  20. Random surfaces and strings

    International Nuclear Information System (INIS)

    Ambjoern, J.

    1987-08-01

    The theory of strings is the theory of random surfaces. I review the present attempts to regularize the world sheet of the string by triangulation. The corresponding statistical theory of triangulated random surfaces has a surprising rich structure, but the connection to conventional string theory seems non-trivial. (orig.)

  1. Dynamics of Carroll strings

    Energy Technology Data Exchange (ETDEWEB)

    Cardona, Biel [Departament d’Estructura i Constituents de la Matèriaand Institut de Ciències del Cosmos (ICCUB) Facultat de Física, Universitat de Barcelona,Diagonal 647, E-08028 Barcelona, Catalonia (Spain); Gomis, Joaquim [Departament d’Estructura i Constituents de la Matèriaand Institut de Ciències del Cosmos (ICCUB) Facultat de Física, Universitat de Barcelona,Diagonal 647, E-08028 Barcelona, Catalonia (Spain); Department of Physics, Faculty of Science, Chulalongkorn University,Bangkok 10330 (Thailand); Pons, Josep M. [Departament d’Estructura i Constituents de la Matèriaand Institut de Ciències del Cosmos (ICCUB) Facultat de Física, Universitat de Barcelona,Diagonal 647, E-08028 Barcelona, Catalonia (Spain)

    2016-07-11

    We construct the canonical action of a Carroll string doing the Carroll limit of a canonical relativistic string. We also study the Killing symmetries of the Carroll string, which close under an infinite dimensional algebra. The tensionless limit and the Carroll p-brane action are also discussed.

  2. String Math 2017

    CERN Document Server

    The series of String-Math conferences has developed into a central event on the interface between mathematics and physics related to string theory, quantum field theory and neighboring subjects. The conference will take place from July 24-28 in the main building of Hamburg university. The String-Math conference is organised by the University of Hamburg jointly with DESY Hamburg.

  3. Cosmic strings and inflation

    International Nuclear Information System (INIS)

    Vishniac, E.T.

    1987-01-01

    We examine the compatibility of inflation with the cosmic string theory for galaxy formation. There is a general conflict between having sufficient string tension to effect galaxy formation, and reheating after inflation to a high enough temperature that strings may form in a thermal phase transition. To escape this conflict, we propose a class of models where the inflation is coupled to the string-producing field. The strings are formed late in inflation as the inflaton rolls towards its zero-temperature value. A large subset of these models have a novel large-scale distribution of galaxies that is fractal, displays biasing without dynamics or feedback mechanisms, and contains voids. (orig.)

  4. Minimal open strings

    International Nuclear Information System (INIS)

    Hosomichi, Kazuo

    2008-01-01

    We study FZZT-branes and open string amplitudes in (p, q) minimal string theory. We focus on the simplest boundary changing operators in two-matrix models, and identify the corresponding operators in worldsheet theory through the comparison of amplitudes. Along the way, we find a novel linear relation among FZZT boundary states in minimal string theory. We also show that the boundary ground ring is realized on physical open string operators in a very simple manner, and discuss its use for perturbative computation of higher open string amplitudes.

  5. Closed Strings From Nothing

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence, Albion

    2001-07-25

    We study the physics of open strings in bosonic and type II string theories in the presence of unstable D-branes. When the potential energy of the open string tachyon is at its minimum, Sen has argued that only closed strings remain in the perturbative spectrum. We explore the scenario of Yi and of Bergman, Hori and Yi, who argue that the open string degrees of freedom are strongly coupled and disappear through confinement. We discuss arguments using open string field theory and worldsheet boundary RG flows, which seem to indicate otherwise. We then describe a solitonic excitation of the open string tachyon and gauge field with the charge and tension of a fundamental closed string. This requires a double scaling limit where the tachyon is taken to its minimal value and the electric field is taken to its maximum value. The resulting flux tube has an unconstrained spatial profile; and for large fundamental string charge, it appears to have light, weakly coupled open strings living in the core. We argue that the flux tube acquires a size or order {alpha}' through sigma model and string coupling effects; and we argue that confinement effects make the light degrees of freedom heavy and strongly interacting.

  6. Closed Strings From Nothing

    International Nuclear Information System (INIS)

    Lawrence, Albion

    2001-01-01

    We study the physics of open strings in bosonic and type II string theories in the presence of unstable D-branes. When the potential energy of the open string tachyon is at its minimum, Sen has argued that only closed strings remain in the perturbative spectrum. We explore the scenario of Yi and of Bergman, Hori and Yi, who argue that the open string degrees of freedom are strongly coupled and disappear through confinement. We discuss arguments using open string field theory and worldsheet boundary RG flows, which seem to indicate otherwise. We then describe a solitonic excitation of the open string tachyon and gauge field with the charge and tension of a fundamental closed string. This requires a double scaling limit where the tachyon is taken to its minimal value and the electric field is taken to its maximum value. The resulting flux tube has an unconstrained spatial profile; and for large fundamental string charge, it appears to have light, weakly coupled open strings living in the core. We argue that the flux tube acquires a size or order α' through sigma model and string coupling effects; and we argue that confinement effects make the light degrees of freedom heavy and strongly interacting

  7. The arithmetic of strings

    International Nuclear Information System (INIS)

    Freund, P.G.O.

    1988-01-01

    According to the author nobody has succeeded as yet in extracting any new numbers from string theory. This paper discusses how if one cannot get new numbers from string theory, maybe one can get new strings out of number theory. Number theory is generally regarded as the purest form of mathematics. So how can it conceivably make contact with physics which aims at describing nature? The author discusses how the connecting link of these two disciplines is provided by the compact Riemann surfaces. These appear as world sheets of interacting strings. For instance, string-string scattering at the three-loop level involves the four external strings attaching themselves to a genus three compact surface

  8. Affinity Strings: Enterprise Data for Resource Recommendations

    Directory of Open Access Journals (Sweden)

    Shane Nackerud

    2008-12-01

    Full Text Available The University of Minnesota Libraries have created a MyLibrary portal, with databases and e-journals targeted to users, based on their affiliations. The University's enterprise authentication system provides an "affinity string", now used to personalize the MyLibrary portal. This affinity string automates discovery of a user's relationship to the University--describing a user's academic department and degree program or position at the University. Affinity strings also provide the Libraries with an anonymized view of resource usage, allowing data collection that respects users' privacy and lays the groundwork for automated recommendation of relevant resources based on the practices and habits of their peers.

  9. Targeted disruption of the mouse Csrp2 gene encoding the cysteine- and glycine-rich LIM domain protein CRP2 result in subtle alteration of cardiac ultrastructure

    Directory of Open Access Journals (Sweden)

    Stoll Doris

    2008-08-01

    Full Text Available Abstract Background The cysteine and glycine rich protein 2 (CRP2 encoded by the Csrp2 gene is a LIM domain protein expressed in the vascular system, particularly in smooth muscle cells. It exhibits a bimodal subcellular distribution, accumulating at actin-based filaments in the cytosol and in the nucleus. In order to analyze the function of CRP2 in vivo, we disrupted the Csrp2 gene in mice and analysed the resulting phenotype. Results A ~17.3 kbp fragment of the murine Csrp2 gene containing exon 3 through 6 was isolated. Using this construct we confirmed the recently determined chromosomal localization (Chromosome 10, best fit location between markers D10Mit203 proximal and D10Mit150 central. A gene disruption cassette was cloned into exon 4 and a mouse strain lacking functional Csrp2 was generated. Mice lacking CRP2 are viable and fertile and have no obvious deficits in reproduction and survival. However, detailed histological and electron microscopic studies reveal that CRP2-deficient mice have subtle alterations in their cardiac ultrastructure. In these mice, the cardiomyocytes display a slight increase in their thickness, indicating moderate hypertrophy at the cellular level. Although the expression of several intercalated disc-associated proteins such as β-catenin, N-RAP and connexin-43 were not affected in these mice, the distribution of respective proteins was changed within heart tissue. Conclusion We conclude that the lack of CRP2 is associated with alterations in cardiomyocyte thickness and hypertrophy.

  10. BRST invariant mixed string vertex for the bosonic string

    International Nuclear Information System (INIS)

    Clarizia, A.; Pezzella, F.

    1987-09-01

    We construct a BRST invariant (N+M)-string vertex including both open and closed string states. When we saturate it with N open string and M closed string physical states it reproduces their corresponding scattering amplitude. As a particular case we obtain BRST invariant vertex for the open-closed string transition. (orig.)

  11. Open-closed string correspondence in open string field theory

    International Nuclear Information System (INIS)

    Baumgartl, M.; Sachs, I.

    2008-01-01

    We address the problem of describing different closed string backgrounds in background independent open string field theory: A shift in the closed string background corresponds to a collective excitation of open strings. As an illustration we apply the formalism to the case where the closed string background is a group manifold. (Abstract Copyright [2008], Wiley Periodicals, Inc.)

  12. Strings, texture, and inflation

    International Nuclear Information System (INIS)

    Hodges, H.M.; Primack, J.R.

    1991-01-01

    We examine mechanisms, several of which are proposed here, to generate structure formation, or to just add large-scale features, through either gauged or global cosmic strings or global texture, within the framework of inflation. We first explore the possibility that strings or texture form if there is no coupling between the topological theory and the inflaton or spacetime curvature, via (1) quantum creation, and (2) a sufficiently high reheat temperature. In addition, we examine the prospects for the inflaton field itself to generate strings or texture. Then, models with the string/texture field coupled to the curvature, and an equivalent model with coupling to the inflaton field, are considered in detail. The requirement that inflationary density fluctuations are not so large as to conflict with observations leads to a number of constraints on model parameters. We find that strings of relevance for structure formation can form in the absence of coupling to the inflaton or curvature through the process of quantum creation, but only if the strings are strongly type I, or if they are global strings. If formed after reheating, naturalness suggests that gauged cosmic strings correspond to a type-I superconductor. Similarly, gauged strings formed during inflation via conformal coupling ξ=1/6 to the spacetime curvature (in a model suggested by Yokoyama in order to evade the millisecond pulsar constraint on cosmic strings) are expected to be strongly type I

  13. Highly excited strings I: Generating function

    Directory of Open Access Journals (Sweden)

    Dimitri P. Skliros

    2017-03-01

    Full Text Available This is the first of a series of detailed papers on string amplitudes with highly excited strings (HES. In the present paper we construct a generating function for string amplitudes with generic HES vertex operators using a fixed-loop momentum formalism. We generalise the proof of the chiral splitting theorem of D'Hoker and Phong to string amplitudes with arbitrary HES vertex operators (with generic KK and winding charges, polarisation tensors and oscillators in general toroidal compactifications E=RD−1,1×TDcr−D (with generic constant Kähler and complex structure target space moduli, background Kaluza–Klein (KK gauge fields and torsion. We adopt a novel approach that does not rely on a “reverse engineering” method to make explicit the loop momenta, thus avoiding a certain ambiguity pointed out in a recent paper by Sen, while also keeping the genus of the worldsheet generic. This approach will also be useful in discussions of quantum gravity and in particular in relation to black holes in string theory, non-locality and breakdown of local effective field theory, as well as in discussions of cosmic superstrings and their phenomenological relevance. We also discuss the manifestation of wave/particle (or rather wave/string duality in string theory.

  14. Topics in string theory

    International Nuclear Information System (INIS)

    Neveu, A.

    1986-01-01

    There exist several string models. In the first lecture, the simplest one, the open bosonic string, which turns out to live most naturally in 26 dimensions will be described in some detail. In the second lecture, the closed bosonic strings, and the open and closed 10-dimensional strings (superstrings) are reviewed. In the third lecture, various compactification schemes which have been proposed to deal with the extra space dimensions, from 4 to 10 or 26 are dealt with; in particular, the Frenkel-Kac construction which builds non-Abelian internal symmetry groups out of the compactified dimensions, and the resulting heterotic string are described. Finally, in the fourth lecture, the important problem of the second quantization of string theories, and of the underlying gauge invariance which is responsible for the possibility of dealing, in a consistent fashion, with interacting high-spin states without negative metric is addressed. 41 references, 8 figures

  15. Characterization of the Entire Cystatin Gene Family in Barley and Their Target Cathepsin L-Like Cysteine-Proteases, Partners in the Hordein Mobilization during Seed Germination1[W

    Science.gov (United States)

    Martinez, Manuel; Cambra, Ines; Carrillo, Laura; Diaz-Mendoza, Mercedes; Diaz, Isabel

    2009-01-01

    Plant cystatins are inhibitors of cysteine-proteases of the papain C1A and legumain C13 families. Cystatin data from multiple plant species have suggested that these inhibitors act as defense proteins against pests and pathogens and as regulators of protein turnover. In this study, we characterize the entire cystatin gene family from barley (Hordeum vulgare), which contain 13 nonredundant genes, and identify and characterize their target enzymes, the barley cathepsin L-like proteases. Cystatins and proteases were expressed and purified from Escherichia coli cultures. Each cystatin was found to have different inhibitory capability against barley cysteine-proteases in in vitro inhibitory assays using specific substrates. Real-time reverse transcription-polymerase chain reaction revealed that inhibitors and enzymes present a wide variation in their messenger RNA expression patterns. Their transcripts were mainly detected in developing and germinating seeds, and some of them were also expressed in leaves and roots. Subcellular localization of cystatins and cathepsin L-like proteases fused to green fluorescent protein demonstrated the presence of both protein families throughout the endoplasmic reticulum and the Golgi complex. Proteases and cystatins not only colocalized but also interacted in vivo in the plant cell, as revealed by bimolecular fluorescence complementation. The functional relationship between cystatins and cathepsin L-like proteases was inferred from their common implication as counterparts of mobilization of storage proteins upon barley seed germination. The opposite pattern of transcription expression in gibberellin-treated aleurones presented by inhibitors and enzymes allowed proteases to specifically degrade B, C, and D hordeins stored in the endosperm of barley seeds. PMID:19759340

  16. Strings and quantum gravity

    International Nuclear Information System (INIS)

    Vega, H.J. de

    1990-01-01

    One of the main challenges in theoretical physics today is the unification of all interactions including gravity. At present, string theories appear as the most promising candidates to achieve such a unification. However, gravity has not completely been incorporated in string theory, many technical and conceptual problems remain and a full quantum theory of gravity is still non-existent. Our aim is to properly understand strings in the context of quantum gravity. Attempts towards this are reviewed. (author)

  17. 6d string chains

    Science.gov (United States)

    Gadde, Abhijit; Haghighat, Babak; Kim, Joonho; Kim, Seok; Lockhart, Guglielmo; Vafa, Cumrun

    2018-02-01

    We consider bound states of strings which arise in 6d (1,0) SCFTs that are realized in F-theory in terms of linear chains of spheres with negative self-intersections 1,2, and 4. These include the strings associated to N small E 8 instantons, as well as the ones associated to M5 branes probing A and D type singularities in M-theory or D5 branes probing ADE singularities in Type IIB string theory. We find that these bound states of strings admit (0,4) supersymmetric quiver descriptions and show how one can compute their elliptic genera.

  18. QCD and string theories

    International Nuclear Information System (INIS)

    Cohen-Tannoudji, G.

    1990-01-01

    This paper is devoted to a review of the connections between quantumchromodynamics (QCD) and string theories. One reviews the phenomenological models leading to string pictures in non perturbative QCD and the string effects, related to soft gluon coherence, which arise in perturbative QCD. One tries to build a string theory which goes to QCD at the zero slope limit. A specific model, based on superstring theories is shown to agree with QCD four point amplitudes at the Born approximation and with one loop corrections. One shows how this approach can provide a theoretical framework to account for the phenomenological property of parton-hadron duality

  19. Thermodynamics of quantum strings

    CERN Document Server

    Morgan, M J

    1994-01-01

    A statistical mechanical analysis of an ideal gas of non-relativistic quantum strings is presented, in which the thermodynamic properties of the string gas are calculated from a canonical partition function. This toy model enables students to gain insight into the thermodynamics of a simple 'quantum field' theory, and provides a useful pedagogical introduction to the more complicated relativistic string theories. A review is also given of the thermodynamics of the open bosonic string gas and the type I (open) superstring gas. (author)

  20. Interpolating string field theories

    International Nuclear Information System (INIS)

    Zwiebach, B.

    1992-01-01

    This paper reports that a minimal area problem imposing different length conditions on open and closed curves is shown to define a one-parameter family of covariant open-closed quantum string field theories. These interpolate from a recently proposed factorizable open-closed theory up to an extended version of Witten's open string field theory capable of incorporating on shell closed strings. The string diagrams of the latter define a new decomposition of the moduli spaces of Riemann surfaces with punctures and boundaries based on quadratic differentials with both first order and second order poles

  1. Heterotic cosmic strings

    International Nuclear Information System (INIS)

    Becker, Katrin; Becker, Melanie; Krause, Axel

    2006-01-01

    We show that all three conditions for the cosmological relevance of heterotic cosmic strings, the right tension, stability and a production mechanism at the end of inflation, can be met in the strongly coupled M-theory regime. Whereas cosmic strings generated from weakly coupled heterotic strings have the well-known problems posed by Witten in 1985, we show that strings arising from M5-branes wrapped around 4-cycles (divisors) of a Calabi-Yau in heterotic M-theory compactifications solve these problems in an elegant fashion

  2. Stretching cosmic strings

    International Nuclear Information System (INIS)

    Turok, N.; Bhattacharjee, P.

    1984-01-01

    The evolution of a network of strings produced at a grand-unification phase transition in an expanding universe is discussed, with particular reference to the processes of energy exchange between the strings and the rest of the universe. This is supported by numerical calculations simulating the behavior of strings in an expanding universe. It is found that in order that the energy density of the strings does not come to dominate the total energy density there must be an efficient mechanism for energy loss: the only plausible one being the production of closed loops and their subsequent decay via gravitational radiation

  3. QCD and hadronic strings

    International Nuclear Information System (INIS)

    Cohen-Tannoudji, G.

    1989-01-01

    This series of lectures is devoted to review ot he connections between QCD and string theories. One reviews the phenomenological models leading to string pictures in non perturbative QCD and the string effects, related to soft gluon coherence, which arise in perturbative QCD. One tries to build a string theory which goes to QCD at the zero slope limit. A specific model, based on superstring theories is shown to agree with QCD four point amplitudes at the Born approximation and with one loop corrections. One shows how this approach can provide a theoretical framework to account for the phenomenological property of parton-hadron duality.(author)

  4. Accidental symmetries and the effective Lagrangian of string theory

    International Nuclear Information System (INIS)

    Ovrut, B.A.

    1989-01-01

    In this paper the relationship between accidental worldsheet symmetries of the string generating functional and target space invariance groups is discussed. Accidental symmetries are used to derive the invariance groups and effective low energy Lagrangian for the bosonic string, and the heterotic string compactified to four-dimensions on Z N orbifolds. The necessity of a new type of Green-Schwarz mechanism, associated with the auxiliary vector field in the four-dimensional N = 1 supergravity multiplet, is shown using these methods

  5. Complex world-sheets from N=2 strings

    International Nuclear Information System (INIS)

    Barbon, J.L.F.

    1996-01-01

    We study some properties of target space strings constructed from (2,1) heterotic strings. We argue that world-sheet complexification is a general property of the bosonic sector of such target world-sheets. We give a target space interpretation of this fact and relate it to the non-gaussian nature of free string field theory. We provide several one-loop calculations supporting the stringy construction of critical world-sheets in terms of (2,1) models. Using finite-temperature boundary conditions in the underlying (2,1) string we obtain non-chiral target space spin structures, and point out some of the problems arising for chiral spin structures, such as the heterotic world-sheet. To this end, we study the torus partition function of the corresponding asymmetric orbifold of the (2,1) string. (orig.)

  6. Twisting the N=2 string

    International Nuclear Information System (INIS)

    Ketov, S.V.; Lechtenfeld, O.; Parkes, A.J.

    1993-12-01

    The most general homogeneous monodromy conditions in N= 2 string theory are classified in terms of the conjugacy classes of the global symmetry group U(1, 1) x Z 2 . For classes which generate a discrete subgroup Γ, the corresponding target space backgrounds C 1,1 /Γ include half spaces, complex orbifolds and tori. We propose a generalization of the intercept formula to matrix-valued twists, and find massless physical states in a number of twisted cases. In particular, the sixteen Z 2 -twisted sectors of the N = 2 string are investigated, and the corresponding ground states are identified via bosonization and BRST cohomology. We find enough room for an extended multiplet of 'spacetime' supersymmetry, with the number of supersymmetries being dependent on global 'spacetime' topology. Unfortunately, world-sheet locality for the chiral vertex operators does not permit interactions for the massless 'spacetime' fermions; however possibly, an asymmetric GSO projection could evade this problem. (orig.)

  7. Semilocal and electroweak strings

    NARCIS (Netherlands)

    Achucarro, A; Vachaspati, T

    We review a class of non-topological defects in the standard electroweak model, and their implications. Starting with the semilocal string, which provides a counterexample to many well-known properties of topological vortices, we discuss electroweak strings and their stability with and without

  8. Disordered chaotic strings

    DEFF Research Database (Denmark)

    Schäfer, Mirko; Greiner, Martin

    2011-01-01

    to chaotic strings. Inhomogeneous coupling weights as well as small-world perturbations of the ring-network structure are discussed. It is found that certain combinations of coupling and network disorder preserve the empirical relationship between chaotic strings and the weak and strong sector...

  9. A rotating string

    International Nuclear Information System (INIS)

    Jensen, B.

    1993-06-01

    The author presents a global solution of Einstein's equations which represents a rotating cosmic string with a finite coreradius. The importance of pressure for the generation of closed timelike curves outside the coreregion of such strings is clearly displayed in this model due to the simplicity of the source. 10 refs

  10. Derandomizing from random strings

    NARCIS (Netherlands)

    Buhrman, H.; Fortnow, L.; Koucký, M.; Loff, B.

    2010-01-01

    In this paper we show that BPP is truth-table reducible to the set of Kolmogorov random strings R(K). It was previously known that PSPACE, and hence BPP is Turing-reducible to R(K). The earlier proof relied on the adaptivity of the Turing-reduction to find a Kolmogorov-random string of polynomial

  11. Unification of string dualities

    International Nuclear Information System (INIS)

    Sen, A.

    1997-01-01

    We argue that all conjectured dualities involving various string, M- and F-theory compactifications can be 'derived' from the conjectured duality between type I and SO(32) heterotic string theory, T-dualities and the definition of M-and F-theories. (orig.)

  12. Optimal Packed String Matching

    DEFF Research Database (Denmark)

    Ben-Kiki, Oren; Bille, Philip; Breslauer, Dany

    2011-01-01

    In the packed string matching problem, each machine word accommodates – characters, thus an n-character text occupies n/– memory words. We extend the Crochemore-Perrin constantspace O(n)-time string matching algorithm to run in optimal O(n/–) time and even in real-time, achieving a factor – speed...

  13. Introduction to string theory

    CERN Multimedia

    CERN. Geneva. Audiovisual Unit

    2002-01-01

    I will present a simple and non-technical overview of string theory, aimed for non-experts who like to get some idea what string theory is about. Besides introductory material, I intend to cover also some of the more recent developments.

  14. StringForce

    DEFF Research Database (Denmark)

    Barendregt, Wolmet; Börjesson, Peter; Eriksson, Eva

    2017-01-01

    In this paper, we present the forced collaborative interaction game StringForce. StringForce is developed for a special education context to support training of collaboration skills, using readily available technologies and avoiding the creation of a "mobile bubble". In order to play String......Force two or four physically collocated tablets are required. These tablets are connected to form one large shared game area. The game can only be played by collaborating. StringForce extends previous work, both technologically and regarding social-emotional training. We believe String......Force to be an interesting demo for the IDC community, as it intertwines several relevant research fields, such as mobile interaction and collaborative gaming in the special education context....

  15. String-Math 2015

    CERN Document Server

    2015-01-01

    Welcome to String-Math 2015 at Sanya. The conference will be opened in December 31, 2015- January 4, 2016. String theory plays a central role in theoretical physics as a candidate for the quantum theory unifying gravity with other interactions. It has profound connections with broad branches of modern mathematics ever since the birth. In the last decades, the prosperous interaction, built upon the joint efforts from both mathematicians and physicists, has given rise to marvelous deep results in supersymmetric gauge theory, topological string, M-theory and duality on the physics side as well as in algebraic geometry, differential geometry, algebraic topology, representation theory and number theory on the mathematics side. The interplay is two-fold. The mathematics has provided powerful tools to fulfill the physical interconnection of ideas and clarify physical structures to understand the nature of string theory. On the other hand, ideas from string theory and quantum field theory have been a source of sign...

  16. Open string model building

    International Nuclear Information System (INIS)

    Ishibashi, Nobuyuki; Onogi, Tetsuya

    1989-01-01

    Consistency conditions of open string theories, which can be a powerful tool in open string model building, are proposed. By making use of these conditions and assuming a simple prescription for the Chan-Paton factors, open string theories in several backgrounds are studied. We show that 1. there exist a large number of consistent bosonic open string theories on Z 2 orbifolds, 2. SO(32) type I superstring is the unique consistent model among fermionic string theories on the ten-dimensional flat Minkowski space, and 3. with our prescription for the Chan-Paton factors, there exist no consistent open superstring theories on (six-dimensional Minkowski space-time) x (Z 2 orbifold). (orig.)

  17. The mitochondrial toxicity of cysteine-S-conjugates: Studies with pentachlorobutadienyl-L-cysteine

    International Nuclear Information System (INIS)

    Wallin, A.

    1990-01-01

    Nephrotoxic cysteine conjugates, arising from mercapturate biosynthesis, can perturb the mitochondrial membrane potential and calcium homeostasis in renal epithelial cells. Activation of these cysteine conjugates to reactive species by mitochondrial β-lyases results in covalent binding and mitochondrial damage. PCBC and related cysteine conjugates inhibit ADP-stimulated respiration in mitochondria respiring on alpha-ketoglutrate/malate and succinate indicating that both dehydrogenases may be targets. The respiratory inhibition is blocked by aminooxyacetic acid, an inhibitor of the β-lyase. Hence, metabolic activation is required implying that covalent binding of reactive intermediates may be important to the mitochondrial injury. Binding of 35 S-fragments has been found for 5 conjugates with varying degrees of mitochondrial toxicity. PCBC is more lipophilic and has a higher affinity for cellular membranes than other cysteine conjugates. PCBC rapidly depolarizes the inner membrane potential resulting in an inhibition of mitochondrial oxidative phosphorylation and calcium upon sequestration. Consequently, mitochondria and renal epithelial cells exposed to PCBC show a sudden release of calcium upon exposure to PCBC which is followed by a later increase in state 4 respiration leading to an inhibition of oxidative phosphorylation. The primary effect of other cysteine conjugates is an inhibition of the dehydrogenases, thus inhibiting state 3 respiration

  18. A reduced covariant string model for the extrinsic string

    International Nuclear Information System (INIS)

    Botelho, L.C.L.

    1989-01-01

    It is studied a reduced covariant string model for the extrinsic string by using Polyakov's path integral formalism. On the basis of this reduced model it is suggested that the extrinsic string has its critical dimension given by 13. Additionally, it is calculated in a simple way Poliakov's renormalization group law for the string rigidity coupling constants. (A.C.A.S.) [pt

  19. Electron string phenomenon: physics and use

    Science.gov (United States)

    Donets, Evgeny D.

    2004-01-01

    Electron string phenomenon arises as a result of phase transition of a state of multiply reflected electron beam to this new discovered state of one component electron plasma and can be easily observed in the reflex mode of EBIS operation. The transition goes via a strong instability, which causes considerable electron energy spread, which in its turn suppresses the instability. Electron string state is a stationary state of hot pure electron plasma, which is heated by injected electron beam and cooled because of electron loses. Electron string is quiet in broad regions of experimental parameters, so that it is used for confinement and ionization of positive ions by electron impact to highly charge states similar to electron beams in EBIS. Application of electron strings instead of electron beams for ion production allows to save about 99% of electric power of electron beam and simultaneously to improve reliability of an ion source considerably. The JINR EBIS `Krion-2' in the string mode of operation is used for production of N7+, Ar16+ and Fe24+ ion beams and their acceleration to relativistic energies on the facility of the JINR super conducting one turn injection synchrotron `Nuklotron'. The tubular electron string possibly can exist and it is under study now theoretically and experiments are prepared now. Estimations show that a Tubular Electron String Ion Source (TESIS) could have up to three orders of magnitude higher ion output then a Linear one (LESIS). In frames of nuclear astrophysics electron strings can be used for research of fusion nuclear reactions at low energies in conditions when both beam and target nuclei do not carry orbital electrons. The project NARITA — Nuclear Astrophysics Researches in an Ion Trap Apparatus is proposed. Polarization effects also can be studied.

  20. Electron string phenomenon: physics and use

    International Nuclear Information System (INIS)

    Donets, Evgeny D

    2004-01-01

    Electron string phenomenon arises as a result of phase transition of a state of multiply reflected electron beam to this new discovered state of one component electron plasma and can be easily observed in the reflex mode of EBIS operation. The transition goes via a strong instability, which causes considerable electron energy spread, which in its turn suppresses the instability. Electron string state is a stationary state of hot pure electron plasma, which is heated by injected electron beam and cooled because of electron loses. Electron string is quiet in broad regions of experimental parameters, so that it is used for confinement and ionization of positive ions by electron impact to highly charge states similar to electron beams in EBIS. Application of electron strings instead of electron beams for ion production allows to save about 99% of electric power of electron beam and simultaneously to improve reliability of an ion source considerably. The JINR EBIS 'Krion-2' in the string mode of operation is used for production of N 7+ , Ar 16+ and Fe 24+ ion beams and their acceleration to relativistic energies on the facility of the JINR super conducting one turn injection synchrotron 'Nuklotron'. The tubular electron string possibly can exist and it is under study now theoretically and experiments are prepared now. Estimations show that a Tubular Electron String Ion Source (TESIS) could have up to three orders of magnitude higher ion output then a Linear one (LESIS). In frames of nuclear astrophysics electron strings can be used for research of fusion nuclear reactions at low energies in conditions when both beam and target nuclei do not carry orbital electrons. The project NARITA - Nuclear Astrophysics Researches in an Ion Trap Apparatus is proposed. Polarization effects also can be studied

  1. Comparison of string models for heavy ion collisions

    International Nuclear Information System (INIS)

    Werner, K.

    1990-01-01

    An important method to explore new domains in physics is to compare new results with extrapolations from known areas. For heavy ion collision this can be done with string models, which extrapolate from light to heavy systems and which also may be used to extrapolate to higher energies. That does not mean that these string models are only background models, one may easily implement new ideas on top of the known aspects, providing much more reliable models than those formed from scratch. All the models to be considered in this paper have in common that they consist of three independent building blocks: (a) geometry, (b) string formation and (c) string fragmentation. The geometry aspect is treated quite similar in all models: nucleons are distributed inside each nucleus according to some standard parameterization of nuclear densities. The nuclei move through each other on a straight line trajectory, with all the nucleon positions being fixed. Whenever a projectile and a target nucleon come close, they interact. Such an interaction results in string formation. In the last step these strings decay into observable hadrons according to some string fragmentation procedure. The three building blocks are independent, so one can combine different methods in an arbitrary manner. Therefore rather than treating the models one after the other, the author discusses the procedures for string formation and string fragmentation as used by the models. He considers string models in a very general sense, so he includes models where the authors never use the word string, but which may be most naturally interpreted as string models and show strong similarities with real string models. Although very important he does not discuss - for time and space reasons - recent developments concerning secondary scattering

  2. String field theory

    International Nuclear Information System (INIS)

    Kaku, M.

    1987-01-01

    In this article, the authors summarize the rapid progress in constructing string field theory actions, such as the development of the covariant BRST theory. They also present the newer geometric formulation of string field theory, from which the BRST theory and the older light cone theory can be derived from first principles. This geometric formulation allows us to derive the complete field theory of strings from two geometric principles, in the same way that general relativity and Yang-Mills theory can be derived from two principles based on global and local symmetry. The geometric formalism therefore reduces string field theory to a problem of finding an invariant under a new local gauge group they call the universal string group (USG). Thus, string field theory is the gauge theory of the universal string group in much the same way that Yang-Mills theory is the gauge theory of SU(N). The geometric formulation places superstring theory on the same rigorous group theoretical level as general relativity and gauge theory

  3. Duality relation between charged elastic strings and superconducting cosmic strings

    International Nuclear Information System (INIS)

    Carter, B.

    1989-01-01

    The mechanical properties of macroscopic electromagnetically coupled string models in a flat or curved background are treated using a covariant formalism allowing the construction of a duality transformation that relates the category of uniform ''electric'' string models, constructed as the (nonconducting) charged generalisation of ordinary uncoupled (violin type) elastic strings, to a category of ''magnetic'' string models comprising recently discussed varieties of ''superconducting cosmic strings''. (orig.)

  4. Lattice gravity and strings

    International Nuclear Information System (INIS)

    Jevicki, A.; Ninomiya, M.

    1985-01-01

    We are concerned with applications of the simplicial discretization method (Regge calculus) to two-dimensional quantum gravity with emphasis on the physically relevant string model. Beginning with the discretization of gravity and matter we exhibit a discrete version of the conformal trace anomaly. Proceeding to the string problem we show how the direct approach of (finite difference) discretization based on Nambu action corresponds to unsatisfactory treatment of gravitational degrees. Based on the Regge approach we then propose a discretization corresponding to the Polyakov string. In this context we are led to a natural geometric version of the associated Liouville model and two-dimensional gravity. (orig.)

  5. Superconducting cosmic strings

    International Nuclear Information System (INIS)

    Chudnovsky, E.M.; Field, G.B.; Spergel, D.N.; Vilenkin, A.

    1986-01-01

    Superconducting loops of string formed in the early Universe, if they are relatively light, can be an important source of relativistic particles in the Galaxy. They can be observed as sources of synchrotron radiation at centimeter wavelengths. We propose a string model for two recently discovered radio sources, the ''thread'' in the galactic center and the source G357.7-0.1, and predict that the filaments in these sources should move at relativistic speeds. We also consider superheavy superconducting strings, and the possibility that they be observed as extragalactic radio sources

  6. Final Report: "Strings 2014"

    Energy Technology Data Exchange (ETDEWEB)

    Witten, Edward

    2015-10-21

    The Strings 2014 meeting was held at Princeton University June 23-27, 2014, co-sponsored by Princeton University and the Institute for Advanced Study. The goal of the meeting was to provide a stimulating and up-to-date overview of research in string theory and its relations to other areas of physics and mathematics, ranging from geometry to quantum field theory, condensed matter physics, and more. This brief report lists committee members and speakers but contains no scientific information. Note that the talks at Strings 2014 were videotaped and are available on the conference website: http://physics.princeton.edustrings2014/Talk_titles.shtml.

  7. A disintegrating cosmic string

    International Nuclear Information System (INIS)

    Griffiths, J B; Docherty, P

    2002-01-01

    We present a simple sandwich gravitational wave of the Robinson-Trautman family. This is interpreted as representing a shock wave with a spherical wavefront which propagates into a Minkowski background minus a wedge (i.e. the background contains a cosmic string). The deficit angle (the tension) of the string decreases through the gravitational wave, which then ceases. This leaves an expanding spherical region of Minkowski space behind it. The decay of the cosmic string over a finite interval of retarded time may be considered to generate the gravitational wave. (letter to the editor)

  8. Baryon string model

    International Nuclear Information System (INIS)

    Klimenko, S.V.; Kochin, V.N.; Plyushchaj, M.S.; Pron'ko, G.P.; Razumov, A.V.; Samarin, A.V.

    1985-01-01

    Partial solutions to classical equations of three-string motion are considered. Simplest solutions, when three-string center moving with high velocity, are co nsidered. Single-mode solutions are studied. Explicit form of their parametrization is obtained and three-string dynamics visualization is made. Means of graphic packet ''Atom'' were used for visualization. A set of processes for graphic representation of multiparametric functions is developed. Peculiarity of these processes is a wide class of functions, which are represented by parametric, coordinate and functional isolines

  9. Exceptional groups from open strings

    International Nuclear Information System (INIS)

    Gaberdiel, M.R.; Zwiebach, B.

    1998-01-01

    We consider type IIB theory compactified on a two-sphere in the presence of mutually non-local 7-branes. The BPS states associated with the gauge vectors of exceptional groups are seen to arise from open strings connecting the 7-branes, and multi-pronged open strings capable of ending on more than two 7-branes. These multi-pronged strings are built from open string junctions that arise naturally when strings cross 7-branes. The different string configurations can be multiplied as traditional open strings, and are shown to generate the structure of exceptional groups. (orig.)

  10. Cosmic strings and cosmic structure

    International Nuclear Information System (INIS)

    Albrecht, A.; Brandenberger, R.; Turok, N.

    1987-01-01

    The paper concerns the application of the theory of cosmic strings to explain the structure of the Universe. The formation of cosmic strings in the early Universe is outlined, along with the Big Bang theory, Grand Unified theories, and the first three minutes after the Big Bang. A description is given of the shaping of the Universe by cosmic strings, including the evolution of the string. The possibility for direct observation of cosmic strings is discussed. (U.K.)

  11. International conference on string theory

    CERN Document Server

    2017-01-01

    The Strings 2017 conference is part of the "Strings" series of annual conferences, that bring the entire string theory community together. It will include reviews of major developments in the field, and specialized talks on specific topics. There will also be several public lectures given by conference participants, a pre-Strings school at the Technion, and a post-Strings workshop at the Weizmann Institute.

  12. String-math 2012

    CERN Document Server

    Katz, Sheldon; Klemm, Albrecht; Morrison, David R

    2015-01-01

    This volume contains the proceedings of the conference String-Math 2012, which was held July 16-21, 2012, at the Hausdorff Center for Mathematics, Universitat Bonn. This was the second in a series of annual large meetings devoted to the interface of mathematics and string theory. These meetings have rapidly become the flagship conferences in the field. Topics include super Riemann surfaces and their super moduli, generalized moonshine and K3 surfaces, the latest developments in supersymmetric and topological field theory, localization techniques, applications to knot theory, and many more. The contributors include many leaders in the field, such as Sergio Cecotti, Matthias Gaberdiel, Rahul Pandharipande, Albert Schwarz, Anne Taormina, Johannes Walcher, Katrin Wendland, and Edward Witten. This book will be essential reading for researchers and students in this area and for all mathematicians and string theorists who want to update themselves on developments in the math-string interface.

  13. Hydroball string sensing system

    International Nuclear Information System (INIS)

    Hurwitz, M.J.; Ekeroth, D.E.; Squarer, D.

    1991-01-01

    This patent describes a hydroball string sensing system for a nuclear reactor having a core containing a fluid at a fluid pressure. It comprises a tube connectable to the nuclear reactor so that the fluid can flow within the tube at a fluid pressure that is substantially the same as the fluid pressure of the nuclear reactor core; a hydroball string including - a string member having objects positioned therealong with a specified spacing, the object including a plurality of hydroballs, and bullet members positioned at opposing ends of the string member; first sensor means, positioned outside a first segment of the tube, for sensing one of the objects being positioned within the first segment, and for providing a sensing signal responsive to the sensing of the first sensing means

  14. The QCD Effective String

    International Nuclear Information System (INIS)

    Espriu, D.

    2003-01-01

    QCD can be described in a certain kinematical regime by an effective string theory. This string must couple to background chiral fields in a chirally invariant manner, thus taking into account the true chirally non-invariant QCD vacuum. By requiring conformal symmetry of the string and the unitarity constraint on chiral fields we reconstruct the equations of motion for the latter ones. These provide a consistent background for the propagation of the string. By further requiring locality of the effective action we recover the Lagrangian of non-linear sigma model of pion interactions. The prediction is unambiguous and parameter-free. The estimated chiral structural constants of Gasser and Leutwyler fit very well the phenomenological values. (author)

  15. Field theory of strings

    International Nuclear Information System (INIS)

    Ramond, P.

    1987-01-01

    We review the construction of the free equations of motion for open and closed strings in 26 dimensions, using the methods of the Florida Group. Differing from previous treatments, we argue that the constraint L 0 -anti L 0 =0 should not be imposed on all the fields of the closed string in the gauge invariant formalism; we show that it can be incorporated in the gauge invariant formalism at the price of being unable to extract the equations of motion from a Langrangian. We then describe our purely algebraic method to introduce interactions, which works equally well for open and closed strings. Quartic interactions are absent except in the Physical Gauge. Finally, we speculate on the role of the measure of the open string path functional. (orig.)

  16. String Theory Rocks!

    CERN Multimedia

    2008-01-01

    String Theory supporters argue that the universe we live in has eleven dimensions, out of which three spacial dimensions and a temporal one, which define the void and the space-time environment we experience daily.

  17. Nonrelativistic closed string theory

    International Nuclear Information System (INIS)

    Gomis, Jaume; Ooguri, Hirosi

    2001-01-01

    We construct a Galilean invariant nongravitational closed string theory whose excitations satisfy a nonrelativistic dispersion relation. This theory can be obtained by taking a consistent low energy limit of any of the conventional string theories, including the heterotic string. We give a finite first order worldsheet Hamiltonian for this theory and show that this string theory has a sensible perturbative expansion, interesting high energy behavior of scattering amplitudes and a Hagedorn transition of the thermal ensemble. The strong coupling duals of the Galilean superstring theories are considered and are shown to be described by an eleven-dimensional Galilean invariant theory of light membrane fluctuations. A new class of Galilean invariant nongravitational theories of light-brane excitations are obtained. We exhibit dual formulations of the strong coupling limits of these Galilean invariant theories and show that they exhibit many of the conventional dualities of M theory in a nonrelativistic setting

  18. String theory compactifications

    CERN Document Server

    Graña, Mariana

    2017-01-01

    The lectures in this book provide graduate students and non-specialist researchers with a concise introduction to the concepts and formalism required to reduce the ten-dimensional string theories to the observable four-dimensional space-time - a procedure called string compactification. The text starts with a very brief introduction to string theory, first working out its massless spectrum and showing how the condition on the number of dimensions arises. It then dwells on the different possible internal manifolds, from the simplest to the most relevant phenomenologically, thereby showing that the most elegant description is through an extension of ordinary Riemannian geometry termed generalized geometry, which was first introduced by Hitchin. Last but not least, the authors review open problems in string phenomenology, such as the embedding of the Standard Model and obtaining de Sitter solutions.

  19. Heterotic string construction

    International Nuclear Information System (INIS)

    Schellekens, A.N.

    1989-01-01

    In this paper an elementary introduction to the principles of four-dimensional string construction will be given. Although the emphasis is on lattice constructions, almost all results have further, and often quite straightforward generalizations to other constructions. Since heterotic strings look phenomenologically more promising than type-II theories the authors only consider the former, although everything can easily be generalized to type-II theories. Some additional aspects of lattice constructions are discussed, and an extensive review can be found

  20. Confusing the heterotic string

    International Nuclear Information System (INIS)

    Benett, D.L.; Mizrachi, L.

    1986-01-01

    A confusion mechanism is proposed as a global modification of the heterotic string model. It envolves a confusion hypersurface across which the two E 8 's of the heterotic string are permuted. A remarkable numerical coincidence is found which prevents an inconsistency in the model. The low energy limit of this theory (after compactification) is typically invariant under one E 8 only, thereby removing the shadow world from the original model. (orig.)

  1. Confusing the heterotic string

    Science.gov (United States)

    Benett, D.; Brene, N.; Mizrachi, Leah; Nielsen, H. B.

    1986-10-01

    A confusion mechanism is proposed as a global modification of the heterotic string model. It envolves a confusion hypersurface across which the two E 8's of the heterotic string are permuted. A remarkable numerical coincidence is found which prevents an inconsistency in the model. The low energy limit of this theory (after compactification) is typically invariant under one E 8 only, thereby removing the shadow world from the original model.

  2. Confusing the heterotic string

    Energy Technology Data Exchange (ETDEWEB)

    Benett, D.L.; Brene, N.; Nielsen, H.B.; Mizrachi, L.

    1986-10-02

    A confusion mechanism is proposed as a global modification of the heterotic string model. It envolves a confusion hypersurface across which the two E/sub 8/'s of the heterotic string are permuted. A remarkable numerical coincidence is found which prevents an inconsistency in the model. The low energy limit of this theory (after compactification) is typically invariant under one E/sub 8/ only, thereby removing the shadow world from the original model.

  3. Lectures on string theory

    International Nuclear Information System (INIS)

    Thorn, C.B.

    1988-01-01

    Several topics are discussed in string theory presented as three lectures to the Spring School on Superstrings at the ICTP at Trieste, Italy, in April, 1988. The first lecture is devoted to some general aspects of conformal invariance and duality. The second sketches methods for carrying out perturbative calculations in string field theory. The final lecture presents an alternative lattice approach to a nonperturbative formulation of the sum over world surfaces. 35 refs., 12 figs

  4. String dynamics in QCD

    International Nuclear Information System (INIS)

    Gervais, J.L.; Neveu, A.

    1980-01-01

    Recent works of the authors on string interpretation of the Wilson loop operators in QCD are reviewed in a self-contained fashion. Although most of the results habe already appeared in print, some new material is presented in renormalization of the Wilson loop operator and on the use of light-cone expansion to derive a linear string-like equation in light-cone formalism. (orig.)

  5. Matrix String Theory

    CERN Document Server

    Dijkgraaf, R; Verlinde, Herman L

    1997-01-01

    Via compactification on a circle, the matrix model of M-theory proposed by Banks et al suggests a concrete identification between the large N limit of two-dimensional N=8 supersymmetric Yang-Mills theory and type IIA string theory. In this paper we collect evidence that supports this identification. We explicitly identify the perturbative string states and their interactions, and describe the appearance of D-particle and D-membrane states.

  6. Manipulating Strings in Python

    Directory of Open Access Journals (Sweden)

    William J. Turkel

    2012-07-01

    Full Text Available This lesson is a brief introduction to string manipulation techniques in Python. Knowing how to manipulate strings plays a crucial role in most text processing tasks. If you’d like to experiment with the following lessons, you can write and execute short programs as we’ve been doing, or you can open up a Python shell / Terminal to try them out on the command line.

  7. Cysteine proteinases and cystatins

    Directory of Open Access Journals (Sweden)

    Adeliana S. Oliveira

    2003-01-01

    Full Text Available This review describeds the definition, localization, functions and examples of cysteine proteinases and their protein inhibitors in vertebrate, non-vertebrate animals and plants. These inhibitors are related with defense mechanisms of plant against pests. It also describes the factors involved in the specific cysteine proteinase-cystatin interaction and high degree of affinity and large specificity in this interaction which are not only represented by the compatibility between amino acid residues of the active site involved in catalysis, but also of all amino acid residues that participante in the enzyme-inhibitor interaction.Nesta revisão foram descritas definições, localizações, funções e exemplos de proteinases cisteínicas e suas proteinas inibidoras em animais vertebrados e invertebrados e plantas. Tratamos principalmente com aqueles inibidores que são relatados com o mecanismo de defesa da planta contra pestes. Em adição, comentamos sobre recentes trabalhos que contribuíram para uma melhor compreenção dos fatores envolvidos na interação específica proteinase cisteínica-cistatina. Por outro lado, chamamos atenção para o alto grau de afinidade e grande especificidade na interação que não são apenas representadas pela compatibilidade entre os residuos de aminoácidos do sítio ativo envolvidos na catalise, mas também de todos os resíduos de aminoácidos que participam da interação enzima-inibidor.

  8. Kahler stabilized, modular invariant heterotic string models

    International Nuclear Information System (INIS)

    Gaillard, Mary K.; Gaillard, Mary K.; Nelson, Brent D.

    2007-01-01

    We review the theory and phenomenology of effective supergravity theories based on orbifold compactifications of the weakly-coupled heterotic string. In particular, we consider theories in which the four-dimensional theory displays target space modular invariance and where the dilatonic mode undergoes Kahler stabilization. A self-contained exposition of effective Lagrangian approaches to gaugino condensation and heterotic string theory is presented, leading to the development of the models of Bintruy, Gaillard and Wu. Various aspects of the phenomenology of this class of models are considered. These include issues of supersymmetry breaking and superpartner spectra, the role of anomalous U(1) factors, issues of flavor and R-parity conservation, collider signatures, axion physics, and early universe cosmology. For the vast majority of phenomenological considerations the theories reviewed here compare quite favorably to other string-derived models in the literature. Theoretical objections to the framework and directions for further research are identified and discussed

  9. Deterministic indexing for packed strings

    DEFF Research Database (Denmark)

    Bille, Philip; Gørtz, Inge Li; Skjoldjensen, Frederik Rye

    2017-01-01

    Given a string S of length n, the classic string indexing problem is to preprocess S into a compact data structure that supports efficient subsequent pattern queries. In the deterministic variant the goal is to solve the string indexing problem without any randomization (at preprocessing time...... or query time). In the packed variant the strings are stored with several character in a single word, giving us the opportunity to read multiple characters simultaneously. Our main result is a new string index in the deterministic and packed setting. Given a packed string S of length n over an alphabet σ...

  10. Strings and fundamental physics

    International Nuclear Information System (INIS)

    Baumgartl, Marco; Brunner, Ilka; Haack, Michael

    2012-01-01

    The basic idea, simple and revolutionary at the same time, to replace the concept of a point particle with a one-dimensional string, has opened up a whole new field of research. Even today, four decades later, its multifaceted consequences are still not fully conceivable. Up to now string theory has offered a new way to view particles as different excitations of the same fundamental object. It has celebrated success in discovering the graviton in its spectrum, and it has naturally led scientists to posit space-times with more than four dimensions - which in turn has triggered numerous interesting developments in fields as varied as condensed matter physics and pure mathematics. This book collects pedagogical lectures by leading experts in string theory, introducing the non-specialist reader to some of the newest developments in the field. The carefully selected topics are at the cutting edge of research in string theory and include new developments in topological strings, AdS/CFT dualities, as well as newly emerging subfields such as doubled field theory and holography in the hydrodynamic regime. The contributions to this book have been selected and arranged in such a way as to form a self-contained, graduate level textbook. (orig.)

  11. Strings and fundamental physics

    Energy Technology Data Exchange (ETDEWEB)

    Baumgartl, Marco [Hamburg Univ. (Germany). 2. Inst. fuer Theoretische Physik; Brunner, Ilka; Haack, Michael (eds.) [Muenchen Univ. (Germany). Fakultaet fuer Physik

    2012-07-01

    The basic idea, simple and revolutionary at the same time, to replace the concept of a point particle with a one-dimensional string, has opened up a whole new field of research. Even today, four decades later, its multifaceted consequences are still not fully conceivable. Up to now string theory has offered a new way to view particles as different excitations of the same fundamental object. It has celebrated success in discovering the graviton in its spectrum, and it has naturally led scientists to posit space-times with more than four dimensions - which in turn has triggered numerous interesting developments in fields as varied as condensed matter physics and pure mathematics. This book collects pedagogical lectures by leading experts in string theory, introducing the non-specialist reader to some of the newest developments in the field. The carefully selected topics are at the cutting edge of research in string theory and include new developments in topological strings, AdS/CFT dualities, as well as newly emerging subfields such as doubled field theory and holography in the hydrodynamic regime. The contributions to this book have been selected and arranged in such a way as to form a self-contained, graduate level textbook. (orig.)

  12. Perspectives on string phenomenology

    CERN Document Server

    Kane, Gordon; Kumar, Piyush

    2015-01-01

    The remarkable recent discovery of the Higgs boson at the CERN Large Hadron Collider completed the Standard Model of particle physics and has paved the way for understanding the physics which may lie beyond it. String/M theory has emerged as a broad framework for describing a plethora of diverse physical systems, which includes condensed matter systems, gravitational systems as well as elementary particle physics interactions. If string/M theory is to be considered as a candidate theory of Nature, it must contain an effectively four-dimensional universe among its solutions that is indistinguishable from our own. In these solutions, the extra dimensions of string/M Theory are “compactified” on tiny scales which are often comparable to the Planck length. String phenomenology is the branch of string/M theory that studies such solutions, relates their properties to data, and aims to answer many of the outstanding questions of particle physics beyond the Standard Model. This book contains perspectives on stri...

  13. Coulomb string tension, asymptotic string tension, and the gluon chain

    OpenAIRE

    Greensite, Jeff; Szczepaniak, Adam P.

    2014-01-01

    We compute, via numerical simulations, the non-perturbative Coulomb potential of pure SU(3) gauge theory in Coulomb gauge. We find that that the Coulomb potential scales nicely in accordance with asymptotic freedom, that the Coulomb potential is linear in the infrared, and that the Coulomb string tension is about four times larger than the asymptotic string tension. We explain how it is possible that the asymptotic string tension can be lower than the Coulomb string tension by a factor of four.

  14. Assay of cysteine dioxygenase activity

    International Nuclear Information System (INIS)

    Bagley, P.J.; Stipanuk, M.H.

    1990-01-01

    It has been proposed that rat liver contains two cysteine dioxygenase enzymes which convert cysteine to cysteinesulfinic acid, one which is stimulated by NAD + and has a pH optimum of 6.8 and one which is not stimulated by NAD + and has a pH optimum of 9.0. This led the authors to reinvestigate assay conditions for measuring cysteine dioxygenase activity in rat liver homogenate. An HPLC method, using an anion exchange column (Dionex Amino-Pac trademark PA1 (4x250 mm)) was used to separate the [ 35 S]cysteinesulfinic acid produced from [ 35 S]cysteine in the incubation mixture. They demonstrated that inclusion of hydroxylamine prevented further metabolism of cysteinesulfinic acid. which occurred rapidly in the absence of hydroxylamine

  15. Interacting-string picture of the fermionic string

    International Nuclear Information System (INIS)

    Mandelstam, S.

    1986-01-01

    This report gives a review of the interacting-string picture of the Bose string. In the present lecture, the author outlines a similar treatment of the Fermionic string. The quantization of the free Fermionic string is carried out to the degrees of freedom x, representing the displacement of the string. Also presented are Grassman degrees of freedom S distributed along the string. The report pictures the fermionic string as a string of dipoles. The general picture of the interaction of such strings by joining and splitting is the same as for the Bose string. The author does not at present have the simplest formula for fermion string scattering amplitudes. A less detailed treatment is given than for the Bose string. The report sets up the functional-integration formalism, derives the analog mode, and indicates in general, terms how the conformal transformation to the z-plane may be performed. The paper concludes by stating without proof the formula for the N-article tree amplitude in the manifestly supersymmetric formalism

  16. String field theory solution for any open string background

    Czech Academy of Sciences Publication Activity Database

    Erler, T.; Maccaferri, Carlo

    2014-01-01

    Roč. 10, Oct (2014), 1-37 ISSN 1029-8479 R&D Projects: GA ČR GBP201/12/G028 Institutional support: RVO:68378271 Keywords : tachyon condensation * string field theory * conformal field models in string theory * bosonic strings Subject RIV: BE - Theoretical Physics Impact factor: 6.111, year: 2014

  17. Are Stopped Strings Preferred in Sad Music?

    OpenAIRE

    David Huron; Caitlyn Trevor

    2017-01-01

    String instruments may be played either with open strings (where the string vibrates between the bridge and a hard wooden nut) or with stopped strings (where the string vibrates between the bridge and a performer's finger pressed against the fingerboard). Compared with open strings, stopped strings permit the use of vibrato and exhibit a darker timbre. Inspired by research on the timbre of sad speech, we test whether there is a tendency to use stopped strings in nominally sad music. Specifica...

  18. Strings for quantumchromodynamics

    International Nuclear Information System (INIS)

    Schomerus, V.

    2007-04-01

    During the last decade, intriguing dualities between gauge and string theory have been found and explored. they provide a novel window on strongly couplde gauge physics, including QCD-like models. Based on a short historical review of modern string theory, we explain how so-called AdS/CFT dualities emerged at the end of the 1990s. Some of their concrete implications and remarkable recent progress are then illustrated for the simplest example, namely the multicolor limit of N=4 SYM theory in four dimensions. We end with a few comments on existing extensions to more realistic models and applications, in particular to the sQGP. This text is meant as a non-technical introduction to gauge/string dualities for (particle) physicists. (orig.)

  19. The confining trailing string

    CERN Document Server

    Kiritsis, E; Nitti, F

    2014-01-01

    We extend the holographic trailing string picture of a heavy quark to the case of a bulk geometry dual to a confining gauge theory. We compute the classical trailing confining string solution for a static as well as a uniformly moving quark. The trailing string is infinitely extended and approaches a confining horizon, situated at a critical value of the radial coordinate, along one of the space-time directions, breaking boundary rotational invariance. We compute the equations for the fluctuations around the classical solutions, which are used to obtain boundary force correlators controlling the Langevin dynamics of the quark. The imaginary part of the correlators has a non-trivial low-frequency limit, which gives rise to a viscous friction coefficient induced by the confining vacuum. The vacuum correlators are used to define finite-temperature dressed Langevin correlators with an appropriate high-frequency behavior.

  20. Strings for quantumchromodynamics

    Energy Technology Data Exchange (ETDEWEB)

    Schomerus, V.

    2007-04-15

    During the last decade, intriguing dualities between gauge and string theory have been found and explored. they provide a novel window on strongly couplde gauge physics, including QCD-like models. Based on a short historical review of modern string theory, we explain how so-called AdS/CFT dualities emerged at the end of the 1990s. Some of their concrete implications and remarkable recent progress are then illustrated for the simplest example, namely the multicolor limit of N=4 SYM theory in four dimensions. We end with a few comments on existing extensions to more realistic models and applications, in particular to the sQGP. This text is meant as a non-technical introduction to gauge/string dualities for (particle) physicists. (orig.)

  1. Large-D gravity and low-D strings.

    Science.gov (United States)

    Emparan, Roberto; Grumiller, Daniel; Tanabe, Kentaro

    2013-06-21

    We show that in the limit of a large number of dimensions a wide class of nonextremal neutral black holes has a universal near-horizon limit. The limiting geometry is the two-dimensional black hole of string theory with a two-dimensional target space. Its conformal symmetry explains the properties of massless scalars found recently in the large-D limit. For black branes with string charges, the near-horizon geometry is that of the three-dimensional black strings of Horne and Horowitz. The analogies between the α' expansion in string theory and the large-D expansion in gravity suggest a possible effective string description of the large-D limit of black holes. We comment on applications to several subjects, in particular to the problem of critical collapse.

  2. Quark potential of spontaneous strings

    International Nuclear Information System (INIS)

    German, G.; Kleinert, H.

    1989-01-01

    The authors present some recent developments in string models with an extrinsic curvature term in action. Particular emphasis is placed upon the static quark potential and on the thermal deconfinement properties of spontaneous strings

  3. Cosmic strings and galaxy formation

    International Nuclear Information System (INIS)

    Bertschinger, E.

    1989-01-01

    Cosmic strings have become increasingly popular candidates as seeds for the formation of structure in the universe. This scenario, remains a serious cosmogonical model despite close scrutiny. In constrast, magnetic monopoles and domain walls - relic topological defects as are cosmic strings - are disastrous for cosmology if they are left over from the early universe. The production of heavy cosmic strings is speculative, as it depends on the details of ultrahigh energy physics. Fortunately, speculation about cosmic strings is not entirely idle because, if they exist and are heavy enough to seed galaxy formation, cosmic strings can be detected astronomically. Failure to detect cosmic strings would impose some constraints on grand unified theories (GUTs); their discovery would have exciting consequences for high energy physics and cosmology. This article reviews the basic physics of nonsuperconducting cosmic strings, highlighting the field theory aspects, and provides a progress report on calculations of structure formation with cosmic strings

  4. STRING v10

    DEFF Research Database (Denmark)

    Szklarczyk, Damian; Franceschini, Andrea; Wyder, Stefan

    2015-01-01

    , and the available data exhibit notable differences in terms of quality and completeness. The STRING database (http://string-db.org) aims to provide a critical assessment and integration of protein-protein interactions, including direct (physical) as well as indirect (functional) associations. The new version 10...... into families at various levels of phylogenetic resolution. Further improvements in version 10.0 include a completely redesigned prediction pipeline for inferring protein-protein associations from co-expression data, an API interface for the R computing environment and improved statistical analysis...

  5. Proceedings of strings, 89

    International Nuclear Information System (INIS)

    Arnowitt, R.; Bryan, R.; Duff, M.J.; Nanopoulos, D.; Pope, C.N.

    1990-01-01

    Does string theory provide us with a consistent quantum theory of gravity? Is it that Holy Grail of elementary particle physics, a Theory of Everything with embraces all the forces and particles of Nature? Even if it is, can we extract concrete predictions about our low-energy world that can be tested experimentally at the SSC and other particle accelerators? What does it have to say about the origin of the Universe and the thorny problem of the cosmological constant? Are superstring theories unique, or might the eleven-dimensional supermembrane prove equally consistent? These are just some of the question posed and debated at Strings '89

  6. Introduction to string theory

    International Nuclear Information System (INIS)

    Randjbar-Daemi, S.; Strathdee, J.

    1987-10-01

    These notes are based on a set of six introductory lectures given jointly by the authors. After developing the canonical methods we discuss the covariant quantization of the bosonic as well as the fermionic string. Conformal field theory methods are also introduced and used to calculate the anomaly coefficient, c, as well as the critical dimensions for bosonic and superstrings. We briefly sketch the BRS quantization and then offer an elementary derivation of the anomaly in the ghost number current. Finally, we address the one-loop partition function of the bosonic string and the question of SL(2,Z) invariance. (author). 15 refs

  7. Matrix string partition function

    CERN Document Server

    Kostov, Ivan K; Kostov, Ivan K.; Vanhove, Pierre

    1998-01-01

    We evaluate quasiclassically the Ramond partition function of Euclidean D=10 U(N) super Yang-Mills theory reduced to a two-dimensional torus. The result can be interpreted in terms of free strings wrapping the space-time torus, as expected from the point of view of Matrix string theory. We demonstrate that, when extrapolated to the ultraviolet limit (small area of the torus), the quasiclassical expressions reproduce exactly the recently obtained expression for the partition of the completely reduced SYM theory, including the overall numerical factor. This is an evidence that our quasiclassical calculation might be exact.

  8. Strings draw theorists together

    International Nuclear Information System (INIS)

    Green, Michael

    2000-01-01

    Theorists are confident that they are closer than ever to finding a quantum theory that unites gravity with the three other fundamental forces in nature. Many of the leading figures in the world of string theory met at the California Institute of Technology in January to discuss recent progress in the field and to reflect on the state of the theory. The enthusiastic mood of the gathering was based on the fact that string theory provides an elegant framework for a unified theory of all the forces and particles in nature, and also gives a consistent quantum-mechanical description of general relativity. String theory, and more precisely superstring theory, describes the assortment of elementary particles such as quarks and leptons, and the gauge bosons responsible for mediating forces in a unified manner as different modes of vibration of a single extended string. This version of the theory also embodies supersymmetry a conjectured symmetry that unifies fermions and bosons. Furthermore, the fact that the string has a fundamental length scale - the ''string length'' - apparently cures the short-distance problems of uniting general relativity with quantum theory. The main problem with the early formulations of superstring theory was that they emphasized the ''perturbative'' point of view, an approximation that describes string-like quantum-mechanical particles moving through classical (that is non quantum-mechanical) space-time. However, very general arguments require that any quantum theory of gravity should also describe space-time geometry in a quantum-mechanical manner. The classical geometry of space-time should then emerge as an approximate description at distance scales much larger than the so-called Planck scale of 10 -33 m. This requires an understanding of the theory beyond the perturbative approximation. It is the quest for this more fundamental description of string theory that has provided the main challenge for string theorists over the past decade. Much

  9. Deriving the four-string and open-closed string interactions from geometric string field theory

    International Nuclear Information System (INIS)

    Kaku, M.

    1990-01-01

    One of the questions concerning the covariant open string field theory is why there are two distinct BRST theories and why the four-string interaction appears in one version but not the other. The authors solve this mystery by showing that both theories are gauge-fixed versions of a higher gauge theory, called the geometric string field theory, with a new field, a string verbein e μσ νρ , which allows us to gauge the string length and σ parametrization. By fixing the gauge, the authors can derive the endpoint gauge (the covariantized light cone gauge), the midpoint gauge of Witten, or the interpolating gauge with arbitrary string length. The authors show explicitly that the four-string interaction is a gauge artifact of the geometric theory (the counterpart of the four-fermion instantaneous Coulomb term of QED). By choosing the interpolating gauge, they produce a new class of four-string interactions which smoothly interpolate between the endpoint gauge and the midpoint gauge (where it vanishes). Similarly, they can extract the closed string as a bound state of the open string, which appears in the endpoint gauge but vanishes in the midpoint gauge. Thus, the four-string and open-closed string interactions do not have to be added to the action as long as the string vierbein is included

  10. Racetrack inflation and cosmic strings

    Energy Technology Data Exchange (ETDEWEB)

    Brax, P. [CEA-Saclay, Gif sur Yvette (France). CEA/DSM/SPhT, Unite de Recherche Associee au CNRS, Service de Physique Theorique; Bruck, C. van de [Sheffield Univ. (United Kingdom). Dept. of Applied Mathematics; Davis, A.C.; Davis, S.C. [Cambridge Univ. (United Kingdom). DAMTP, Centre for Mathematical Sciences; Jeannerot, R. [Instituut-Lorentz for Theoretical Physics, Leiden (Netherlands); Postma, M. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)]|[Nationaal Inst. voor Kernfysica en Hoge-Energiefysica (NIKHEF), Amsterdam (Netherlands)

    2008-05-15

    We consider the coupling of racetrack inflation to matter fields as realised in the D3/D7 brane system. In particular, we investigate the possibility of cosmic string formation in this system. We find that string formation before or at the onset of racetrack inflation is possible, but they are then inflated away. Furthermore, string formation at the end of inflation is prevented by the presence of the moduli sector. As a consequence, no strings survive racetrack inflation. (orig.)

  11. String theory in four dimensions

    International Nuclear Information System (INIS)

    Dine, M.

    1988-01-01

    A representative sample of current ideas about how one might develop a string phenomenology is presented. Some of the obstacles which lie in between string theory and contact with experiment are described. It is hoped that this volume will provide the reader with ways of thinking about string theory in four dimensions and provide tools for asking questions about string theory and ordinary physics. 102 refs

  12. The STRING database in 2011

    DEFF Research Database (Denmark)

    Szklarczyk, Damian; Franceschini, Andrea; Kuhn, Michael

    2011-01-01

    present an update on the online database resource Search Tool for the Retrieval of Interacting Genes (STRING); it provides uniquely comprehensive coverage and ease of access to both experimental as well as predicted interaction information. Interactions in STRING are provided with a confidence score...... models, extensive data updates and strongly improved connectivity and integration with third-party resources. Version 9.0 of STRING covers more than 1100 completely sequenced organisms; the resource can be reached at http://string-db.org....

  13. Instability of colliding metastable strings

    Energy Technology Data Exchange (ETDEWEB)

    Hiramatsu, Takashi [Kyoto Univ. (Japan). Yukawa Inst. for Theoretical Physics; Eto, Minoru [Yamagata Univ. (Japan). Dept. of Physics; Kamada, Kohei [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Kobayashi, Tatsuo [Kyoto Univ. (Japan). Dept. of Physics; Ookouchi, Yutaka [Kyoto Univ. (Japan). Dept. of Physics; Kyoto Univ. (Japan). The Hakubi Center for Advanced Research

    2013-04-15

    We investigate the collision dynamics of two metastable strings which can be viewed as tube-like domain walls with winding numbers interpolating a false vacuum and a true vacuum. We find that depending on the relative angle and speed of two strings, instability of strings increases and the false vacuum is filled out by rapid expansion of the strings or of a remnant of the collision.

  14. Cosmic strings and galaxy formation

    Science.gov (United States)

    Bertschinger, Edmund

    1989-01-01

    The cosmogonical model proposed by Zel'dovich and Vilenkin (1981), in which superconducting cosmic strings act as seeds for the origin of structure in the universe, is discussed, summarizing the results of recent theoretical investigations. Consideration is given to the formation of cosmic strings, the microscopic structure of strings, gravitational effects, cosmic string evolution, and the formation of galaxies and large-scale structure. Simulation results are presented in graphs, and several outstanding issues are listed and briefly characterized.

  15. Instability of colliding metastable strings

    International Nuclear Information System (INIS)

    Hiramatsu, Takashi; Kobayashi, Tatsuo; Ookouchi, Yutaka; Kyoto Univ.

    2013-04-01

    We investigate the collision dynamics of two metastable strings which can be viewed as tube-like domain walls with winding numbers interpolating a false vacuum and a true vacuum. We find that depending on the relative angle and speed of two strings, instability of strings increases and the false vacuum is filled out by rapid expansion of the strings or of a remnant of the collision.

  16. Racetrack inflation and cosmic strings

    International Nuclear Information System (INIS)

    Brax, P.; Postma, M.

    2008-05-01

    We consider the coupling of racetrack inflation to matter fields as realised in the D3/D7 brane system. In particular, we investigate the possibility of cosmic string formation in this system. We find that string formation before or at the onset of racetrack inflation is possible, but they are then inflated away. Furthermore, string formation at the end of inflation is prevented by the presence of the moduli sector. As a consequence, no strings survive racetrack inflation. (orig.)

  17. String theory and quark confinement

    International Nuclear Information System (INIS)

    Polyakov, A.M.

    1998-01-01

    This article is based on a talk given at the ''Strings '97'' conference. It discusses the search for the universality class of confining strings. The key ingredients include the loop equations, the zigzag symmetry, the non-linear renormalization group. Some new tests for the equivalence between gauge fields and strings are proposed. (orig.)

  18. String theory in four dimensions

    CERN Document Server

    1988-01-01

    ``String Theory in Four Dimensions'' contains a representative collection of papers dealing with various aspects of string phenomenology, including compactifications on smooth manifolds and more general conformal field theories. Together with the lucid introduction by M. Dine, this material gives the reader a good working knowledge of our present ideas for connecting string theory to nature.

  19. String necklaces and primordial black holes from type IIB strings

    International Nuclear Information System (INIS)

    Lake, Matthew; Thomas, Steve; Ward, John

    2009-01-01

    We consider a model of static cosmic string loops in type IIB string theory, where the strings wrap cycles within the internal space. The strings are not topologically stabilised, however the presence of a lifting potential traps the windings giving rise to kinky cycloops. We find that PBH formation occurs at early times in a small window, whilst at late times we observe the formation of dark matter relics in the scaling regime. This is in stark contrast to previous predictions based on field theoretic models. We also consider the PBH contribution to the mass density of the universe, and use the experimental data to impose bounds on the string theory parameters.

  20. SUPERCOLLIDER: String test success

    International Nuclear Information System (INIS)

    Anon.

    1992-01-01

    On 14 August at the Superconducting Supercollider (SSC) Laboratory in Ellis County, Texas, the Accelerator Systems String Test (ASST) successfully met its objective by operating a half-cell of five collider dipole magnets, one quadrupole magnet, and two spool pieces at the design current of 6500 amperes

  1. Help from the strings

    CERN Multimedia

    2007-01-01

    "How can the nature of basic particles be defined beyond the mechanisms presiding over their creation? Besides the standard model of particle physics - resulting from the postulations of quantum mechanics - contemporary science has pinned its hopes on the totally new unifying notion provided by the highly mathematical string theory."(2 pages)

  2. New Z3 strings

    Directory of Open Access Journals (Sweden)

    Marco A.C. Kneipp

    2016-12-01

    Full Text Available We consider a Yang–Mills–Higgs theory with the gauge group SU(3 broken to its center Z3 by two scalar fields in the adjoint representation and obtain new Z3 strings asymptotic configurations with the gauge field and magnetic field in the direction of the step operators.

  3. On exceptional instanton strings

    NARCIS (Netherlands)

    Del Zotto, M.; Lockhart, G.

    According to a recent classification of 6d (1, 0) theories within F-theory there are only six “pure” 6d gauge theories which have a UV superconformal fixed point. The corresponding gauge groups are SU(3), SO(8), F4, E6, E7, and E8. These exceptional models have BPS strings which are also instantons

  4. String perturbation theory diverges

    International Nuclear Information System (INIS)

    Gross, D.J.; Periwal, V.

    1988-01-01

    We prove that perturbation theory for the bosonic string diverges for arbitrary values of the coupling constant and is not Borel summable. This divergence is independent of the existence of the infinities that occur in the theory due to the presence of tachyons and dilaton tadpoles. We discuss the physical implications of such a divergence

  5. Transversally extended string

    International Nuclear Information System (INIS)

    Akama, Keiichi

    1988-01-01

    Starting with the space-time action of the transversally extended string, we derive its world-sheet action, which is that of a gravitational and gauge theory with matter fields on the world-sheet, with additional effects of the second fundamental quantity. (author)

  6. Lectures on strings and dualities

    International Nuclear Information System (INIS)

    Vafa, C.

    1997-01-01

    In this set of lectures I review recent developments in string theory emphasizing their non-perturbative aspects and their recently discovered duality symmetries. The goal of the lectures is to make the recent exciting developments in string theory accessible to those with no previous background in string theory who wish to join the research effort in this area. Topics covered include a brief review of string theory, its compactifications, solitons and D-branes, black hole entropy and wed of string dualities. (author)

  7. Macroscopic fundamental strings in cosmology

    Energy Technology Data Exchange (ETDEWEB)

    Aharonov, Y; Englert, F; Orloff, J

    1987-12-24

    We show that, when D greater than or equal to 4, theories of closed strings of closed strings in D, non-compact space-time dimensions exhibit a phase transition. The high-temperature phase is characterized by a condensate of arbitrarily long strings with Hausdorff dimension two (area filling curves). We suggest that this stringy phase is the ancestor of the adiabatic era. Fundamental strings could then both drive the inflation and seed, in a way reminiscent of the cosmic string mechanism, the large structures in the universe.

  8. Strings draw theorists together

    Energy Technology Data Exchange (ETDEWEB)

    Green, Michael [Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge (United Kingdom)

    2000-03-01

    Theorists are confident that they are closer than ever to finding a quantum theory that unites gravity with the three other fundamental forces in nature. Many of the leading figures in the world of string theory met at the California Institute of Technology in January to discuss recent progress in the field and to reflect on the state of the theory. The enthusiastic mood of the gathering was based on the fact that string theory provides an elegant framework for a unified theory of all the forces and particles in nature, and also gives a consistent quantum-mechanical description of general relativity. String theory, and more precisely superstring theory, describes the assortment of elementary particles such as quarks and leptons, and the gauge bosons responsible for mediating forces in a unified manner as different modes of vibration of a single extended string. This version of the theory also embodies supersymmetry a conjectured symmetry that unifies fermions and bosons. Furthermore, the fact that the string has a fundamental length scale - the ''string length'' - apparently cures the short-distance problems of uniting general relativity with quantum theory. The main problem with the early formulations of superstring theory was that they emphasized the ''perturbative'' point of view, an approximation that describes string-like quantum-mechanical particles moving through classical (that is non quantum-mechanical) space-time. However, very general arguments require that any quantum theory of gravity should also describe space-time geometry in a quantum-mechanical manner. The classical geometry of space-time should then emerge as an approximate description at distance scales much larger than the so-called Planck scale of 10{sup -33} m. This requires an understanding of the theory beyond the perturbative approximation. It is the quest for this more fundamental description of string theory that has provided the main challenge for

  9. Cysteine Protease Zymography: Brief Review.

    Science.gov (United States)

    Wilkesman, Jeff

    2017-01-01

    Cysteine proteases play multiple roles in basically all aspects of physiology and development. In plants, they are involved in growth and development and in accumulation and mobilization of storage proteins. Furthermore, they are engaged in signalling pathways and in the response to biotic and abiotic stresses. In animals and also in humans, they are responsible for senescence and apoptosis, prohormone processing, and ECM remodelling. When analyzed by zymography, the enzyme must be renaturated after SDS-PAGE. SDS must be washed out and substituted by Triton X-100. Gels are then further incubated under ideal conditions for activity detection. Cysteine proteases require an acidic pH (5.0-6.0) and a reducing agent, usually DTT. When screening biological samples, there is generally no previous clue on what peptidase class will be present, neither optimal proteolysis conditions are known. Hence, it is necessary to assess several parameters, such as incubation time, pH, temperature, influence of ions or reducing agents, and finally evaluate the inhibition profile. For detection of cysteine peptidase activity, the use of specific inhibitors, such as E-64, can be used to prevent the development of cysteine peptidase activity bands and positively confirm its presence. Here four different protocols to assess cysteine protease activity from different sources are presented.

  10. Gravitational effects of global strings

    International Nuclear Information System (INIS)

    Aryal, M.; Everett, A.E.

    1986-01-01

    We have obtained the gravitational field, in the weak-field approximation, of cosmic strings formed in a phase transition in which a global symmetry is broken (global strings). The effect of this field on light rays passing a global string is found, and the resulting formation of double images and production of discontinuities in the microwave background temperature compared with the corresponding results for gauge strings. There are some differences in the case of global strings, reflecting the fact that the space surrounding such strings is not purely conical. However, the differences between gauge and global strings with masses suitable to explain galaxy formation are small, and the task of distinguishing them observationally appears difficult at best

  11. Device for balancing parallel strings

    Science.gov (United States)

    Mashikian, Matthew S.

    1985-01-01

    A battery plant is described which features magnetic circuit means in association with each of the battery strings in the battery plant for balancing the electrical current flow through the battery strings by equalizing the voltage across each of the battery strings. Each of the magnetic circuit means generally comprises means for sensing the electrical current flow through one of the battery strings, and a saturable reactor having a main winding connected electrically in series with the battery string, a bias winding connected to a source of alternating current and a control winding connected to a variable source of direct current controlled by the sensing means. Each of the battery strings is formed by a plurality of batteries connected electrically in series, and these battery strings are connected electrically in parallel across common bus conductors.

  12. A heterotic N=2 string with space-time supersymmetry

    International Nuclear Information System (INIS)

    Bellucci, S.; Galajinsky, A.; Lechtenfeld, O.

    2001-02-01

    It is reconsidered the issue of embedding space-time fermions into the four dimensional N=2 world-sheet supersymmetric string. A new heterotic theory is constructed, taking the right-movers from the N =4 topological extension of the conventional N=2 string but a c=0 conformal field theory supporting target-space supersymmetry for the left-moving sector. The global bosonic symmetry of the full formalism proves to be U(1,1), just as in the usual N=2 string. Quantization reveals a spectrum of only two physical states, one boson and one fermion, which fall in a multiplet of (1,0) supersymmetry

  13. From N=2 strings to M-theory

    International Nuclear Information System (INIS)

    Ketov, S.V.

    1997-01-01

    Taking the N=2 strings as the starting point, we discuss the equivalent self-dual field theories and analyze their symmetry structure in 2 + 2 dimensions. Restoring the full 'Lorentz' invariance in the target space necessarily leads to an extension of the N=2 string theory to a theory of 2 + 2 dimensional supermembranes propagating in 2 + 10 dimensional target space. The supermembrane requires maximal conformal supersymmetry in 2 + 2 dimensions, in the way advocated by Siegel, and it leads to the self-dual N=4 super-Yang-Mills theory and the self-dual N=8 (gauged) supergravity in 2+2 dimensions. The N=2 strings now appear on equal footing with the other string models as particular limits of the M-theory. (orig.)

  14. Stringing physics along

    Energy Technology Data Exchange (ETDEWEB)

    Riordan, M. [Stanford University and the University of California, Santa Cruz (United States)]. E-mail: mriordan@ucsc.edu

    2007-02-15

    In the last few decades, however, physical theory has drifted away from the professional norms advocated by Newton and other enlightenment philosophers. A vast outpouring of hypotheses has occurred under the umbrella of what is widely called string theory. But string theory is not really a 'theory' at all - at least not in the strict sense that scientists generally use the term. It is instead a dense, weedy thicket of hypotheses and conjectures badly in need of pruning. That pruning, however, can come only from observation and experiment, to which string theory (a phrase I will grudgingly continue using) is largely inaccessible. String theory was invented in the 1970s in the wake of the Standard Model of particle physics. Encouraged by the success of gauge theories of the strong, weak and electromagnetic forces, theorists tried to extend similar ideas to energy and distance scales that are orders of magnitude beyond what can be readily observed or measured. The normal, healthy intercourse between theory and experiment - which had led to the Standard Model - has broken down, and fundamental physics now finds itself in a state of crisis. So it is refreshing to hear from a theorist - one who was deeply involved with string theory and championed it in his previous book, Three Roads to Quantum Gravity - that all is not well in this closeted realm. Smolin argues from the outset that viable hypotheses must lead to observable consequences by which they can be tested and judged. String theory by its very nature does not allow for such probing, according to Smolin, and therefore it must be considered as an unprovable conjecture. Towards the end of his book, Smolin suggests other directions fundamental physics can take, particularly in the realm of quantum gravity, to resolve its crisis and reconnect with the observable world. From my perspective, he leans a bit too heavily towards highly speculative ideas such as doubly special relativity, modified Newtonian

  15. Boundary operators in effective string theory

    Energy Technology Data Exchange (ETDEWEB)

    Hellerman, Simeon [Kavli Institute for the Physics and Mathematics of the Universe, The University of Tokyo,Kashiwa, Chiba 277-8582 (Japan); Swanson, Ian [Kavli Institute for the Physics and Mathematics of the Universe, The University of Tokyo,Kashiwa, Chiba 277-8582 (Japan)

    2017-04-13

    Various universal features of relativistic rotating strings depend on the organization of allowed local operators on the worldsheet. In this paper, we study the set of Neumann boundary operators in effective string theory, which are relevant for the controlled study of open relativistic strings with freely moving endpoints. Relativistic open strings are thought to encode the dynamics of confined quark-antiquark pairs in gauge theories in the planar approximation. Neumann boundary operators can be organized by their behavior under scaling of the target space coordinates X{sup μ}, and the set of allowed X-scaling exponents is bounded above by +1/2 and unbounded below. Negative contributions to X-scalings come from powers of a single invariant, or “dressing' operator, which is bilinear in the embedding coordinates. In particular, we show that all Neumann boundary operators are dressed by quarter-integer powers of this invariant, and we demonstrate how this rule arises from various ways of regulating the short-distance singularities of the effective theory.

  16. Real topological string amplitudes

    Energy Technology Data Exchange (ETDEWEB)

    Narain, K.S. [The Abdus Salam International Centre for Theoretical Physics (ICTP),Strada Costiera 11, Trieste, 34151 (Italy); Piazzalunga, N. [Simons Center for Geometry and Physics, State University of New York,Stony Brook, NY, 11794-3636 (United States); International School for Advanced Studies (SISSA) and INFN, Sez. di Trieste,via Bonomea 265, Trieste, 34136 (Italy); Tanzini, A. [International School for Advanced Studies (SISSA) and INFN, Sez. di Trieste,via Bonomea 265, Trieste, 34136 (Italy)

    2017-03-15

    We discuss the physical superstring correlation functions in type I theory (or equivalently type II with orientifold) that compute real topological string amplitudes. We consider the correlator corresponding to holomorphic derivative of the real topological amplitude G{sub χ}, at fixed worldsheet Euler characteristic χ. This corresponds in the low-energy effective action to N=2 Weyl multiplet, appropriately reduced to the orientifold invariant part, and raised to the power g{sup ′}=−χ+1. We show that the physical string correlator gives precisely the holomorphic derivative of topological amplitude. Finally, we apply this method to the standard closed oriented case as well, and prove a similar statement for the topological amplitude F{sub g}.

  17. Open spinning strings

    International Nuclear Information System (INIS)

    Stefanski, B. Jr.

    2004-01-01

    We find classical open string solutions in the AdS 5 x S 5 /Z 2 orientifold with angular momenta along the five-sphere. The energy of these solutions has an expansion in integral powers of λ with sigma-model corrections suppressed by inverse powers of J - the total angular momentum. This gives a prediction for the exact anomalous dimensions of operators in the large N limit of an N = 2 Sp, Super-Yang-Mills theory with matter. We also find a simple map between open and closed string solutions. This gives a prediction for an all-loop planar relationship between the anomalous dimensions of single-trace and two-quark operators in the dual gauge theory. (author)

  18. New Supersymmetric String Compactifications

    Energy Technology Data Exchange (ETDEWEB)

    Kachru, Shamit

    2002-11-25

    We describe a new class of supersymmetric string compactifications to 4d Minkowski space. These solutions involve type II strings propagating on (orientifolds of) non Calabi-Yau spaces in the presence of background NS and RR fluxes. The simplest examples have descriptions as cosets, generalizing the three-dimensional nilmanifold. They can also be thought of as twisted tori. We derive a formula for the (super)potential governing the light fields, which is generated by the fluxes and certain ''twists'' in the geometry. Detailed consideration of an example also gives strong evidence that in some cases, these exotic geometries are related by smooth transitions to standard Calabi-Yau or G2 compactifications of M-theory.

  19. Unified string theories

    International Nuclear Information System (INIS)

    Gross, D.J.

    1985-01-01

    String theories offer a way of realizing the potential of supersymmetry, Kaluza-Klein and much more. They represent a radical departure from ordinary quantum field theory, but in the direction of increased symmetry and structure. They are based on an enormous increase in the number of degrees of freedom, since in addition to fermionic coordinates and extra dimensions, the basic entities are extended one dimensional objects instead of points. Correspondingly the symmetry group is greatly enlarged, in a way that we are only beginning to comprehend. At the very least this extended symmetry contains the largest group of symmetries that can be contemplated within the framework of point field theories-those of ten-dimensional supergravity and super Yang-Mills theory. Types of string theories and the phenomenology to be expected from them are reviewed

  20. Fractional bosonic strings

    Science.gov (United States)

    Diaz, Victor Alfonzo; Giusti, Andrea

    2018-03-01

    The aim of this paper is to present a simple generalization of bosonic string theory in the framework of the theory of fractional variational problems. Specifically, we present a fractional extension of the Polyakov action, for which we compute the general form of the equations of motion and discuss the connection between the new fractional action and a generalization the Nambu-Goto action. Consequently, we analyze the symmetries of the modified Polyakov action and try to fix the gauge, following the classical procedures. Then we solve the equations of motion in a simplified setting. Finally, we present a Hamiltonian description of the classical fractional bosonic string and introduce the fractional light-cone gauge. It is important to remark that, throughout the whole paper, we thoroughly discuss how to recover the known results as an "integer" limit of the presented model.

  1. The LHC string2 supervision system

    CERN Document Server

    Mayya, Y S; Sicard, Claude Henri

    2002-01-01

    This paper describes the implementation of the supervision system for the LHC Prototype Full-Cell also known as String 2. The supervision application is based on a commercial package targeted to industrial controls, but because of the complexity and the specifics of such a system, integration with custom components is necessary in order to merge the industrial requirements with the specificity of the accelerator controls.

  2. p-adic string

    International Nuclear Information System (INIS)

    Volovich, I.V.

    1987-01-01

    The hypothesis of the possible p-adic structure of spacetime is considered. The p-adic Veneziano amplitude is proposed and the main properties of the p-adic string theory are discussed. The analogous questions on the Galois field are also discussed. In this case the Jacobi sum plays the role of the Veneziano amplitude which can be expressed by means of the I-adic cohomology of the Fermat curves. The corresponding vertex operator is given. (author)

  3. Exactly soluble dynamics of (p,q) string near macroscopic fundamental strings

    International Nuclear Information System (INIS)

    Bak, Dongsu; Rey, Soojong; Yee, Houng

    2004-01-01

    We study dynamics of type-IIB bound-state of a Dirichlet string and n fundamental strings in the background of N fundamental strings. Because of supergravity potential, the bound-state string is pulled to the background fundamental strings, whose motion is described by open string rolling radion field. The string coupling can be made controllably weak and, in the limit 1 2 st n 2 st N, the bound-state energy involved is small compared to the string scale. We thus propose rolling dynamics of open string radion in this system as an exactly solvable analog for rolling dynamics of open string tachyon in decaying D-brane. The dynamics bears a novel feature that the worldsheet electric field increases monotonically to the critical value as the bound-state string falls into the background string. Close to the background string, D string constituent inside the bound-state string decouples from fundamental string constituents. (author)

  4. The theta-structure in string theories - 1: bosonic strings

    International Nuclear Information System (INIS)

    Li Miao.

    1985-09-01

    We explored the theta-structures in bosonic string theories which are similar to those in gauge field theories. The theta-structure of string is due to the multiply connected spatial compact subspace of space-time. The work of this paper shows that there is an energy band E(theta) in the string theory and one may move the tachyon out in theory by choosing some proper theta parameters. (author)

  5. An invariant string propagator

    International Nuclear Information System (INIS)

    Cohen, A.; Moore, G.; Nelson, P.; Polchinski, J.

    1986-01-01

    The authors show that the Polyakov path integral is used to define off-shell quantities in string theory. The path integral of Polyakov gives an elegant description of strings and their interactions. However, its use has been limited to obtaining the Koba-Nielsen expressions for S-matrix elements. It is not yet clear what quantities make sense in string theory. This study shows that the path integral can be used to define off-shell quantities as well. In particular it defines a natural n-point function in loop space as the sum of all world surfaces bounded by n specific spacetime curves. The reader is referred for more detail. The report first outlines general evaluation then discusses the additional features added by boundaries. Locally, the three gauge freedoms ξ/sup a/ and δphi can be used to take g/sub ab/ (σ) to the unit matrix. Globally, this is not quite possible. In general the researchers choose a family of fiducial metrics g/sub ab/ (σ,tau), depending on a finite number of Teichmuller parameters tau, and every metric is gauge equivalent to one of these

  6. Thermodynamical string fragmentation

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, Nadine [Theoretical Particle Physics, Department of Astronomy and Theoretical Physics, Lund University,Sölvegatan 14A, Lund, SE-223 62 (Sweden); School of Physics and Astronomy, Monash University,Wellington Road, Clayton, VIC-3800 (Australia); Sjöstrand, Torbjörn [Theoretical Particle Physics, Department of Astronomy and Theoretical Physics, Lund University,Sölvegatan 14A, Lund, SE-223 62 (Sweden)

    2017-01-31

    The observation of heavy-ion-like behaviour in pp collisions at the LHC suggests that more physics mechanisms are at play than traditionally assumed. The introduction e.g. of quark-gluon plasma or colour rope formation can describe several of the observations, but as of yet there is no established paradigm. In this article we study a few possible modifications to the Pythia event generator, which describes a wealth of data but fails for a number of recent observations. Firstly, we present a new model for generating the transverse momentum of hadrons during the string fragmentation process, inspired by thermodynamics, where heavier hadrons naturally are suppressed in rate but obtain a higher average transverse momentum. Secondly, close-packing of strings is taken into account by making the temperature or string tension environment-dependent. Thirdly, a simple model for hadron rescattering is added. The effect of these modifications is studied, individually and taken together, and compared with data mainly from the LHC. While some improvements can be noted, it turns out to be nontrivial to obtain effects as big as required, and further work is called for.

  7. Building GUTs from strings

    International Nuclear Information System (INIS)

    Aldazabal, G.; Ibanez, L.E.; Uranga, A.M.

    1996-01-01

    We study in detail the structure of Grand Unified Theories derived as the low-energy limit of orbifold four-dimensional strings. To this aim, new techniques for building level-two symmetric orbifold theories are presented. New classes of GUTs in the context of symmetric orbifolds are then constructed. The method of permutation modding is further explored and SO(10) GUTs with both 45- or 54-plets are obtained. SU(5) models are also found through this method. It is shown that, in the context of symmetric orbifold SO(10) GUTs, only a single GUT Higgs, either a 54 or a 45, can be present and it always resides in an order-two untwisted sector. Very restrictive results also hold in the case of SU(5). General properties and selection rules for string GUTs are described. Some of these selection rules forbid the presence of some particular GUT-Higgs couplings which are sometimes used in SUSY-GUT model building. Some semi-realistic string GUT examples are presented and their properties briefly discussed. (orig.)

  8. Fingerprints in Compressed Strings

    DEFF Research Database (Denmark)

    Bille, Philip; Cording, Patrick Hagge; Gørtz, Inge Li

    2013-01-01

    The Karp-Rabin fingerprint of a string is a type of hash value that due to its strong properties has been used in many string algorithms. In this paper we show how to construct a data structure for a string S of size N compressed by a context-free grammar of size n that answers fingerprint queries...... derivative that captures LZ78 compression and its variations) we get O(loglogN) query time. Hence, our data structures has the same time and space complexity as for random access in SLPs. We utilize the fingerprint data structures to solve the longest common extension problem in query time O(logNlogℓ) and O....... That is, given indices i and j, the answer to a query is the fingerprint of the substring S[i,j]. We present the first O(n) space data structures that answer fingerprint queries without decompressing any characters. For Straight Line Programs (SLP) we get O(logN) query time, and for Linear SLPs (an SLP...

  9. Biotin Switch Assays for Quantitation of Reversible Cysteine Oxidation.

    Science.gov (United States)

    Li, R; Kast, J

    2017-01-01

    Thiol groups in protein cysteine residues can be subjected to different oxidative modifications by reactive oxygen/nitrogen species. Reversible cysteine oxidation, including S-nitrosylation, S-sulfenylation, S-glutathionylation, and disulfide formation, modulate multiple biological functions, such as enzyme catalysis, antioxidant, and other signaling pathways. However, the biological relevance of reversible cysteine oxidation is typically underestimated, in part due to the low abundance and high reactivity of some of these modifications, and the lack of methods to enrich and quantify them. To facilitate future research efforts, this chapter describes detailed procedures to target the different modifications using mass spectrometry-based biotin switch assays. By switching the modification of interest to a biotin moiety, these assays leverage the high affinity between biotin and avidin to enrich the modification. The use of stable isotope labeling and a range of selective reducing agents facilitate the quantitation of individual as well as total reversible cysteine oxidation. The biotin switch assay has been widely applied to the quantitative analysis of S-nitrosylation in different disease models and is now also emerging as a valuable research tool for other oxidative cysteine modifications, highlighting its relevance as a versatile, robust strategy for carrying out in-depth studies in redox proteomics. © 2017 Elsevier Inc. All rights reserved.

  10. How to simulate global cosmic strings with large string tension

    Energy Technology Data Exchange (ETDEWEB)

    Klaer, Vincent B.; Moore, Guy D., E-mail: vklaer@theorie.ikp.physik.tu-darmstadt.de, E-mail: guy.moore@physik.tu-darmstadt.de [Institut für Kernphysik, Technische Universität Darmstadt, Schlossgartenstraße 2, Darmstadt, D-64289 Germany (Germany)

    2017-10-01

    Global string networks may be relevant in axion production in the early Universe, as well as other cosmological scenarios. Such networks contain a large hierarchy of scales between the string core scale and the Hubble scale, ln( f {sub a} / H ) ∼ 70, which influences the network dynamics by giving the strings large tensions T ≅ π f {sub a} {sup 2} ln( f {sub a} / H ). We present a new numerical approach to simulate such global string networks, capturing the tension without an exponentially large lattice.

  11. Maximal unbordered factors of random strings

    DEFF Research Database (Denmark)

    Cording, Patrick Hagge; Knudsen, Mathias Bæk Tejs

    2016-01-01

    A border of a string is a non-empty prefix of the string that is also a suffix of the string, and a string is unbordered if it has no border. Loptev, Kucherov, and Starikovskaya [CPM 2015] conjectured the following: If we pick a string of length n from a fixed alphabet uniformly at random...

  12. 35S cystein chlorhydrate preparation

    International Nuclear Information System (INIS)

    Emiliozzi, R.; Pichat, P.; Herbert, M.

    1960-01-01

    35 S cystein chlorhydrate has been prepared with a quantitative yield by electrolytic reduction of 35 S cystin in hydrochloric medium on a vibrating mercury cathode. Reprint of a paper published in Bulletin de la Societe chimique de France, no. 2653, 4. quarter 1959, p. 1544-1545 [fr

  13. Dynamics of chaotic strings

    International Nuclear Information System (INIS)

    Schaefer, Mirko

    2011-01-01

    The main topic of this thesis is the investigation of dynamical properties of coupled Tchebycheff map networks. The results give insights into the chaotic string model and its network generalization from a dynamical point of view. As a first approach, discrete symmetry transformations of the model are studied. These transformations are formulated in a general way in order to be also applicable to similar dynamics on bipartite network structures. The dynamics is studied numerically via Lyapunov measures, spatial correlations, and ergodic properties. It is shown that the zeros of the interaction energy are distinguished only with respect to this specific observable, but not by a more general dynamical principle. The original chaotic string model is defined on a one-dimensional lattice (ring-network) as the underlying network topology. This thesis studies a modification of the model based on the introduction of tunable disorder. The effects of inhomogeneous coupling weights as well as small-world perturbations of the ring-network structure on the interaction energy are discussed. Synchronization properties of the chaotic string model and its network generalization are studied in later chapters of this thesis. The analysis is based on the master stability formalism, which relates the stability of the synchronized state to the spectral properties of the network. Apart from complete synchronization, where the dynamics at all nodes of the network coincide, also two-cluster synchronization on bipartite networks is studied. For both types of synchronization it is shown that depending on the type of coupling the synchronized dynamics can display chaotic as well as periodic or quasi-periodic behaviour. The semi-analytical calculations reveal that the respective synchronized states are often stable for a wide range of coupling values even for the ring-network, although the respective basins of attraction may inhabit only a small fraction of the phase space. To provide

  14. Quantum backreaction in string theory

    International Nuclear Information System (INIS)

    Evnin, O.

    2012-01-01

    There are situations in string theory when a finite number of string quanta induce a significant backreaction upon the background and render the perturbation theory infrared-divergent. The simplest example is D0-brane recoil under an impact by closed strings. A more physically interesting case is backreaction on the evolution of a totally compact universe due to closed string gas. Such situations necessitate qualitative amendments to the traditional formulation of string theory in a fixed classical background. In this contribution to the proceedings of the XVII European Workshop on String Theory in Padua, I review solved problems and current investigations in relation to this kind of quantum backreaction effects. (Copyright copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  15. Fast Searching in Packed Strings

    DEFF Research Database (Denmark)

    Bille, Philip

    2009-01-01

    Given strings P and Q the (exact) string matching problem is to find all positions of substrings in Q matching P. The classical Knuth-Morris-Pratt algorithm [SIAM J. Comput., 1977] solves the string matching problem in linear time which is optimal if we can only read one character at the time....... However, most strings are stored in a computer in a packed representation with several characters in a single word, giving us the opportunity to read multiple characters simultaneously. In this paper we study the worst-case complexity of string matching on strings given in packed representation. Let m...... word-RAM with logarithmic word size we present an algorithm using time O(n/log(sigma) n + m + occ) Here occ is the number of occurrences of P in Q. For m = o(n) this improves the O(n) bound...

  16. Comparing double string theory actions

    International Nuclear Information System (INIS)

    De Angelis, L.; Gionti, S.J.G.; Marotta, R.; Pezzella, F.

    2014-01-01

    Aimed to a deeper comprehension of a manifestly T-dual invariant formulation of string theory, in this paper a detailed comparison between the non-covariant action proposed by Tseytlin and the covariant one proposed by Hull is done. These are obtained by making both the string coordinates and their duals explicitly appear, on the same footing, in the world-sheet action, so “doubling” the string coordinates along the compact dimensions. After a discussion on the nature of the constraints in both the models and the relative quantization, it results that the string coordinates and their duals behave like “non-commuting” phase space coordinates but their expressions in terms of Fourier modes generate the oscillator algebra of the standard bosonic string. A proof of the equivalence of the two formulations is given. Furthermore, open-string solutions are also discussed

  17. Comparing double string theory actions

    Energy Technology Data Exchange (ETDEWEB)

    De Angelis, L. [Dipartimento di Fisica, Università degli Studi “Federico II” di Napoli,Complesso Universitario Monte S. Angelo ed. 6, via Cintia, 80126 Napoli (Italy); Gionti, S.J.G. [Specola Vaticana, Vatican City, V-00120, Vatican City State and Vatican Observatory Research Group, Steward Observatory, The University Of Arizona, 933 North Cherry Avenue, Tucson, Arizona 85721 (United States); Marotta, R.; Pezzella, F. [Istituto Nazionale di Fisica Nucleare, Sezione di Napoli,Complesso Universitario di Monte S. Angelo ed. 6, via Cintia, 80126 Napoli (Italy)

    2014-04-28

    Aimed to a deeper comprehension of a manifestly T-dual invariant formulation of string theory, in this paper a detailed comparison between the non-covariant action proposed by Tseytlin and the covariant one proposed by Hull is done. These are obtained by making both the string coordinates and their duals explicitly appear, on the same footing, in the world-sheet action, so “doubling” the string coordinates along the compact dimensions. After a discussion on the nature of the constraints in both the models and the relative quantization, it results that the string coordinates and their duals behave like “non-commuting” phase space coordinates but their expressions in terms of Fourier modes generate the oscillator algebra of the standard bosonic string. A proof of the equivalence of the two formulations is given. Furthermore, open-string solutions are also discussed.

  18. Regularized strings with extrinsic curvature

    International Nuclear Information System (INIS)

    Ambjoern, J.; Durhuus, B.

    1987-07-01

    We analyze models of discretized string theories, where the path integral over world sheet variables is regularized by summing over triangulated surfaces. The inclusion of curvature in the action is a necessity for the scaling of the string tension. We discuss the physical properties of models with extrinsic curvature terms in the action and show that the string tension vanishes at the critical point where the bare extrinsic curvature coupling tends to infinity. Similar results are derived for models with intrinsic curvature. (orig.)

  19. Classical theory of radiating strings

    Science.gov (United States)

    Copeland, Edmund J.; Haws, D.; Hindmarsh, M.

    1990-01-01

    The divergent part of the self force of a radiating string coupled to gravity, an antisymmetric tensor and a dilaton in four dimensions are calculated to first order in classical perturbation theory. While this divergence can be absorbed into a renormalization of the string tension, demanding that both it and the divergence in the energy momentum tensor vanish forces the string to have the couplings of compactified N = 1 D = 10 supergravity. In effect, supersymmetry cures the classical infinities.

  20. Cosmic string induced CMB maps

    International Nuclear Information System (INIS)

    Landriau, M.; Shellard, E. P. S.

    2011-01-01

    We compute maps of CMB temperature fluctuations seeded by cosmic strings using high resolution simulations of cosmic strings in a Friedmann-Robertson-Walker universe. We create full-sky, 18 deg. and 3 deg. CMB maps, including the relevant string contribution at each resolution from before recombination to today. We extract the angular power spectrum from these maps, demonstrating the importance of recombination effects. We briefly discuss the probability density function of the pixel temperatures, their skewness, and kurtosis.

  1. Introduction to strings and superstrings

    International Nuclear Information System (INIS)

    Traubenberg, M.R. de.

    1988-01-01

    We discuss the main features on the formulation of string theory that, in a primitive level, describe the hadronic phenomenon of duality. We also study an extension of the models of closed and strings with spin. Then, by using supersymmetry, it is formulated the theory of superstrings and heterotic strings with the aim of unify the fundamental interactions and matter. (M.W.O.) [pt

  2. Experimenting with string musical instruments

    Science.gov (United States)

    LoPresto, Michael C.

    2012-03-01

    What follows are several investigations involving string musical instruments developed for and used in a Science of Sound & Light course. The experiments make use of a guitar, orchestral string instruments and data collection and graphing software. They are designed to provide students with concrete examples of how mathematical formulae, when used in physics, represent reality that can actually be observed, in this case, the operation of string musical instruments.

  3. String breaking with Wilson loops?

    CERN Document Server

    Kratochvila, S; Kratochvila, Slavo; Forcrand, Philippe de

    2003-01-01

    A convincing, uncontroversial observation of string breaking, when the static potential is extracted from Wilson loops only, is still missing. This failure can be understood if the overlap of the Wilson loop with the broken string is exponentially small. In that case, the broken string ground state will only be seen if the Wilson loop is long enough. Our preliminary results show string breaking in the context of the 3d SU(2) adjoint static potential, using the L\\"uscher-Weisz exponential variance reduction approach. As a by-product, we measure the fundamental SU(2) static potential with improved accuracy and see clear deviations from Casimir scaling.

  4. A primer on string theory

    CERN Document Server

    Schomerus, Volker

    2017-01-01

    Since its conception in the 1960s, string theory has been hailed as one of the most promising routes we have to unify quantum mechanics and general relativity. This book provides a concise introduction to string theory explaining central concepts, mathematical tools and covering recent developments in physics including compactifications and gauge/string dualities. With string theory being a multidisciplinary field interfacing with high energy physics, mathematics and quantum field theory, this book is ideal for both students with no previous knowledge of the field and scholars from other disciplines who are looking for an introduction to basic concepts.

  5. Open problems in string cosmology

    International Nuclear Information System (INIS)

    Toumbas, N.

    2010-01-01

    Some of the open problems in string cosmology are highlighted within the context of the recently constructed thermal and quantum superstring cosmological solutions. Emphasis is given on the high temperature cosmological regime, where it is argued that thermal string vacua in the presence of gravito-magnetic fluxes can be used to bypass the Hagedorn instabilities of string gas cosmology. This article is based on a talk given at the workshop on ''Cosmology and Strings'', Corfu, September 6-13, 2009. (Abstract Copyright [2010], Wiley Periodicals, Inc.)

  6. Multiflavor string-net models

    Science.gov (United States)

    Lin, Chien-Hung

    2017-05-01

    We generalize the string-net construction to multiple flavors of strings, each of which is labeled by the elements of an Abelian group Gi. The same flavor of strings can branch, while different flavors of strings can cross one another and thus they form intersecting string nets. We systematically construct the exactly soluble lattice Hamiltonians and the ground-state wave functions for the intersecting string-net condensed phases. We analyze the braiding statistics of the low-energy quasiparticle excitations and find that our model can realize all the topological phases as the string-net model with group G =∏iGi . In this respect, our construction provides various ways of building lattice models which realize topological order G , corresponding to different partitions of G and thus different flavors of string nets. In fact, our construction concretely demonstrates the Künneth formula by constructing various lattice models with the same topological order. As an example, we construct the G =Z2×Z2×Z2 string-net model which realizes a non-Abelian topological phase by properly intersecting three copies of toric codes.

  7. The ABCDEFG of Little Strings

    OpenAIRE

    Haouzi, Nathan; Kozçaz, Can

    2017-01-01

    Starting from type IIB string theory on an $ADE$ singularity, the (2,0) little string arises when one takes the string coupling $g_s$ to 0. In this setup, we give a unified description of the codimension-two defects of the little string, for any simple Lie algebra ${\\mathfrak{g}}$. Geometrically, these are D5 branes wrapping 2-cycles of the singularity. Equivalently, the defects are specified by a certain set of weights of $^L {\\mathfrak{g}}$, the Langlands dual of ${\\mathfrak{g}}$. As a firs...

  8. String Theory in a Nutshell

    CERN Document Server

    Kiritsis, Elias

    2007-01-01

    This book is the essential new introduction to modern string theory, by one of the world's authorities on the subject. Concise, clearly presented, and up-to-date, String Theory in a Nutshell brings together the best understood and most important aspects of a theory that has been evolving since the early 1980s. A core model of physics that substitutes one-dimensional extended ""strings"" for zero-dimensional point-like particles (as in quantum field theory), string theory has been the leading candidate for a theory that would successfully unify all fundamental forces of nature, includin

  9. Splitting strings on integrable backgrounds

    Energy Technology Data Exchange (ETDEWEB)

    Vicedo, Benoit

    2011-05-15

    We use integrability to construct the general classical splitting string solution on R x S{sup 3}. Namely, given any incoming string solution satisfying a necessary self-intersection property at some given instant in time, we use the integrability of the worldsheet {sigma}-model to construct the pair of outgoing strings resulting from a split. The solution for each outgoing string is expressed recursively through a sequence of dressing transformations, the parameters of which are determined by the solutions to Birkhoff factorization problems in an appropriate real form of the loop group of SL{sub 2}(C). (orig.)

  10. Heterotic string solutions and coset conformal field theories

    CERN Document Server

    Giveon, Amit; Tseytlin, Arkady A

    1993-01-01

    We discuss solutions of the heterotic string theory which are analogous to bosonic and superstring backgrounds related to coset conformal field theories. A class of exact `left-right symmetric' solutions is obtained by supplementing the metric, antisymmetric tensor and dilaton of the superstring solutions by the gauge field background equal to the generalised Lorentz connection with torsion. As in the superstring case, these backgrounds are $\\a'$-independent, i.e. have a `semiclassical' form. The corresponding heterotic string sigma model is obtained from the combination of the (1,0) supersymmetric gauged WZNW action with the action of internal fermions coupled to the target space gauge field. The pure (1,0) supersymmetric gauged WZNW theory is anomalous and does not describe a consistent heterotic string solution. We also find (to the order $\\alpha'^3$) a two-dimensional perturbative heterotic string solution with the trivial gauge field background. To the leading order in $\\alpha'$ it coincides with the kno...

  11. Polynomial invariants for torus knots and topological strings

    International Nuclear Information System (INIS)

    Labastida, J.M.F.

    2001-01-01

    We make a precision test of a recently proposed conjecture relating Chern-Simons gauge theory to topological string theory on the resolution of the conifold. First, we develop a systematic procedure to extract string amplitudes from vacuum expectation values (vevs) of Wilson loops in Chern-Simons gauge theory, and then we evaluate these vevs in arbitrary irreducible representations of SU(N) for torus knots. We find complete agreement with the predictions derived from the target space interpretation of the string amplitudes. We also show that the structure of the free energy of topological open string theory gives further constraints on the Chern-Simons vevs. Our work provides strong evidence towards an interpretation of knot polynomial invariants as generating functions associated to enumerative problems. (orig.)

  12. Strings and superstrings. Electron linear colliders

    International Nuclear Information System (INIS)

    Alessandrini, V.; Bambade, P.; Binetruy, P.; Kounnas, C.; Le Duff, J.; Schwimmer, A.

    1989-01-01

    Basic string theory; strings in interaction; construction of strings and superstrings in arbitrary space-time dimensions; compactification and phenomenology; linear e+e- colliders; and the Stanford linear collider were discussed [fr

  13. Transcription factor DecR (YbaO) controls detoxification of L-cysteine in Escherichia coli.

    Science.gov (United States)

    Shimada, Tomohiro; Tanaka, Kan; Ishihama, Akira

    2016-09-01

    YbaO is an uncharacterized AsnC-family transcription factor of Escherichia coli. In both Salmonella enterica and Pantoea ananatis, YbaO homologues were identified to regulate the adjacent gene encoding cysteine desulfhydrase for detoxification of cysteine. Using the genomic SELEX (systematic evolution of ligands by exponential enrichment) screening system, we identified the yhaOM operon, located far from the ybaO gene on the E. coli genome, as a single regulatory target of YbaO. In both gel shift assay in vitro and reporter and Northern blot assays in vivo, YbaO was found to regulate the yhaOM promoter. The growth of mutants lacking either ybaO or its targets yhaOM was delayed in the presence of cysteine, indicating involvement of these genes in cysteine detoxification. In the major pathway of cysteine degradation, hydrogen sulfide is produced in wild-type E. coli, but its production was not observed in each of the ybaO, yhaO and yhaM mutants. The yhaOM promoter was activated in the presence of cysteine, implying the role of cysteine in activation of YbaO. Taken together, we propose that YbaO is the cysteine-sensing transcriptional activator of the yhaOM operon, which is involved in the detoxification of cysteine. We then propose the naming of ybaO as decR (regulator of detoxification of cysteine).

  14. Strings, Branes and Symmetries

    International Nuclear Information System (INIS)

    Westerberg, A.

    1997-01-01

    Recent dramatic progress in the understanding of the non-perturbative structure of superstring theory shows that extended objects of various kinds, collectively referred to as p-branes, are an integral part of the theory. In this thesis, comprising an introductory text and seven appended research papers, we study various aspects of p-branes with relevance for superstring theory. The first part of the introductory text is a brief review of string theory focussing on the role of p-branes. In particular, we consider the so-called D-branes which currently are attracting a considerable amount of attention. The purpose of this part is mainly to put into context the results of paper 4, 5 and 6 concerning action functionals describing the low-energy dynamics of D-branes. The discussion of perturbative string theory given in this part of the introduction is also intended to provide some background to paper 2 which contains an application of the Reggeon-sewing approach to the construction of string vertices. The second part covers a rather different subject, namely higher-dimensional loop algebras and their cohomology, with the aim of facilitating the reading of papers 1, 3 and 7. The relation to p-branes is to be found in paper 1 where we introduce a certain higher-dimensional generalization of the loop algebra and discuss its potential applicability as a symmetry algebra for p-branes. Papers 3 and 7 are mathematically oriented out-growths of this paper addressing the issue of realizing algebras of this kind, known in physics as current algebras, in terms of pseudo differential operators (PSDOs). The main result of paper 3 is a proof of the equivalence between certain Lie-algebra cocycles on the space of second-quantizable PSDOs

  15. Topics in string theory

    Science.gov (United States)

    Gorbatov, Elie

    In the first part of the dissertation we study noncommutative field theories at finite temperature. We find evidence for winding states and observe the existence of a transition to a new phase where there is a reduction of the degrees of freedom in the non-planar sector of the theory. We emphasize that such a transition is generic and insensitive to the particulars of the UV definition of the theory. In the second part we investigate some aspects of M-theory compactifications on orbifolds. The heterotic E8 x E 8 string compactified on T4/ ZN has gauge group G x G˜ with massless states in the twisted sector charged under both factors. In the dual M-theory description on T4/ ZN x S1/Z 2 the two groups do not communicate with each other since they reside on the boundary of the eleven dimensional spacetime. This leads to a conundrum for the twisted states of the perturbative heterotic string for there does not seem to be local degrees of freedom which carry charges under both G and G˜. We propose a resolution of this apparent paradox by nonperturbative states in M-theory. In support of our argument we review the consideration of six-dimensional gauge couplings and verify the local anomaly cancellation. In order to understand the dynamical properties of these states we deform the orbifold geometry, find an equivalent string theory background, and brane engineer the low energy six-dimensional field theories. In the process we encounter many exotic and surprising phenomena which are intrinsically M-theoretic and completely invisible to the perturbative observer.

  16. Drill string gas data

    Energy Technology Data Exchange (ETDEWEB)

    Siciliano, E.R.

    1998-05-12

    Data and supporting documentation were compiled and analyzed for 26 cases of gas grab samples taken during waste-tank core sampling activities between September 1, 1995 and December 31, 1997. These cases were tested against specific criteria to reduce uncertainties associated with in-tank sampling location and conditions. Of the 26 possible cases, 16 qualified as drill-string grab samples most likely to represent recently released waste gases. The data from these 16 ``confirmed`` cases were adjusted to remove non-waste gas contributions from core-sampling activities (argon or nitrogen purge), the atmospheric background, and laboratory sampler preparation (helium). The procedure for subtracting atmospheric, laboratory, and argon purge gases was unambiguous. No reliable method for determining the exact amount of nitrogen purge gas was established. Thus, the final set of ``Adjusted`` drill string gas data for the 6 nitrogen-purged cases had a greater degree of uncertainty than the final results for the 10 argon-purged cases. Including the appropriate amounts of uncertainty, this final set of data was added to the set of high-quality results from the Retained Gas Sampler (RGS), and good agreement was found for the N{sub 2}, H{sub 2}, and N{sub 2}O mole fractions sampled from common tanks. These results indicate that under favorable sampling conditions, Drill-String (DS) grab samples can provide reasonably accurate information about the dominant species of released gas. One conclusion from this set of total gas data is that the distribution of the H{sub 2} mole fractions is bimodal in shape, with an upper bound of 78%.

  17. Transmutations for Strings

    Directory of Open Access Journals (Sweden)

    Amin Boumenir

    2008-07-01

    Full Text Available We investigate the existence and representation of transmutations, also known as transformation operators, for strings. Using measure theory and functional analytic methods we prove their existence and study their representation. We show that in general they are not close to unity since their representation does not involve a Volterra operator but rather the eigenvalue parameter. We also obtain conditions under which the transmutation is either a bounded or a compact operator. Explicit examples show that they cannot be reduced to Volterra type operators.  

  18. Sequestering in string theory

    International Nuclear Information System (INIS)

    Kachru, Shamit; McAllister, Liam; Sundrum, Raman

    2007-01-01

    We study sequestering, a prerequisite for flavor-blind supersymmetry breaking in several high-scale mediation mechanisms, in compactifications of type IIB string theory. We find that although sequestering is typically absent in unwarped backgrounds, strongly warped compactifications do readily sequester. The AdS/CFT dual description in terms of conformal sequestering plays an important role in our analysis, and we establish how sequestering works both on the gravity side and on the gauge theory side. We pay special attention to subtle compactification effects that can disrupt sequestering. Our result is a step toward realizing an appealing pattern of soft terms in a KKLT compactification

  19. Drilling string lifter

    Energy Technology Data Exchange (ETDEWEB)

    Shakhobalov, A B; Galiopa, A A; Ponomarev, G V; Ushakov, A M

    1981-04-28

    A drilling string lifter is suggested which includes a rotating tower installed on a fixed base, hydraulic cylinder and pipe-clamping assembly connected through a chain gear to the drive motor. In order to simplify the design of the hydraulic lifter, the drive motor is installed on a fixed base so that the axis of the outlet shaft of the drive motor coincides with the axis of rotation of the tower. In addition, the axis of rotation of the tower is made in the form of a tubular element, and the outlet shaft of the drive motor is ranged between the tubular element.

  20. Nuclear fuel string assembly

    International Nuclear Information System (INIS)

    Ip, A.K.; Koyanagi, K.; Tarasuk, W.R.

    1976-01-01

    A method of fabricating rodded fuels suitable for use in pressure tube type reactors and in pressure vessel type reactors is described. Fuel rods are secured as an inner and an outer sub-assembly, each rod attached between mounting rings secured to the rod ends. The two sub-assemblies are telescoped together and positioned by spaced thimbles located between them to provide precise positioning while permittng differential axial movement between the sub-assemblies. Such sub-assemblies are particularly suited for mounting as bundle strings. The method provides particular advantages in the assembly of annular-section fuel pins, which includes booster fuel containing enriched fuel material. (LL)

  1. Some global issues in string perturbation theory

    International Nuclear Information System (INIS)

    Atick, J.J.; Moore, G.; Sen, Ashoke

    1988-01-01

    Calculations of type II string vacuum amplitude using the picture changing prescription have been shown to lead, in general, to a positive cosmological constant. We show that there is a global obstruction to the choices of gauge slice for super-Teichmueller space that lead to such measures. We discuss the general restrictions on gauge slices appropriate for use in explicit fermionic string calculations. We also discuss the relation of the functional determinant and conformal field theory versions of the path integral measure, and show that, at arbitrary genus and in arbitrary backgrounds preserving tree level N=1 supersymmetry, the measure is an exact differential. We evaluate the boundary integrals of this total derivative at genus two in two ways for target space R 10 to show that the integrals are zero. Finally, we use the factorization hypothesis to show that in appropriate compactified spacetimes the boundary integrals continue to vanish. (orig.)

  2. Vacuum strings in FRW models

    Energy Technology Data Exchange (ETDEWEB)

    Dyer, C C; Oattes, L M; Starkman, G D

    1988-01-01

    The authors find that vacuum string solutions cannot be embedded in an FRW model in the spirit of the swiss cheese model for inhomogeneities. Since all standard lensing calculations rely implicitly on the Swiss Cheese model, this result indicates that the previous lensing results for the vacuum string may be in error.

  3. Tadpole resummations in string theory

    International Nuclear Information System (INIS)

    Kitazawa, Noriaki

    2008-01-01

    While R-R tadpoles should be canceled for consistency, string models with broken supersymmetry generally have uncanceled NS-NS tadpoles. Their presence signals that the background does not solve the field equations, so that these models are in 'wrong' vacua. In this Letter we investigate, with reference to some prototype examples, whether the true values of physical quantities can be recovered resumming the NS-NS tadpoles, hence by an approach that is related to the analysis based on String Field Theory by open-closed duality. We show that, indeed, the positive classical vacuum energy of a Dp-brane of the bosonic string is exactly canceled by the negative contribution arising from tree-level tadpole resummation, in complete agreement with Sen's conjecture on open-string tachyon condensation and with the consequent analysis based on String Field Theory. We also show that the vanishing classical vacuum energy of the SO(8192) unoriented bosonic open-string theory does not receive any tree-level corrections from the tadpole resummation. This result is consistent with the fact that this (unstable) configuration is free from tadpoles of massless closed-string modes, although there is a tadpole of the closed string tachyon. The application of this method to superstring models with broken supersymmetry is also discussed

  4. String theory and water waves

    International Nuclear Information System (INIS)

    Iyer, Ramakrishnan; Johnson, Clifford V; Pennington, Jeffrey S

    2011-01-01

    We uncover a remarkable role that an infinite hierarchy of nonlinear differential equations plays in organizing and connecting certain c-hat <1 string theories non-perturbatively. We are able to embed the type 0A and 0B (A, A) minimal string theories into this single framework. The string theories arise as special limits of a rich system of equations underpinned by an integrable system known as the dispersive water wave hierarchy. We observe that there are several other string-like limits of the system, and conjecture that some of them are type IIA and IIB (A, D) minimal string backgrounds. We explain how these and several string-like special points arise and are connected. In some cases, the framework endows the theories with a non-perturbative definition for the first time. Notably, we discover that the Painleve IV equation plays a key role in organizing the string theory physics, joining its siblings, Painleve I and II, whose roles have previously been identified in this minimal string context.

  5. Cool Runnings For String 2

    CERN Multimedia

    2001-01-01

    String 2 is a series of superconducting magnets that are prototypes of those which will be installed in the LHC. It was cooled down to 1.9 Kelvin on September 14th. On Thursday last week, the dipoles of String 2 were successfully taken to nominal current, 11850 A.

  6. N-loop string amplitude

    International Nuclear Information System (INIS)

    Mandelstam, S.

    1986-06-01

    Work on the derivation of an explicit perturbation series for string and superstring amplitudes is reviewed. The light-cone approach is emphasized, but some work on the Polyakov approach is also mentioned, and the two methods are compared. The calculation of the measure factor is outlined in the interacting-string picture

  7. String-localized quantum fields

    International Nuclear Information System (INIS)

    Mund, Jens; Santos, Jose Amancio dos; Silva, Cristhiano Duarte; Oliveira, Erichardson de

    2009-01-01

    Full text. The principles of physics admit (unobservable) quantum fields which are localized not on points, but on strings in the sense of Mandelstam: a string emanates from a point in Minkowski space and extends to infinity in some space-like direction. This type of localization might permit the construction of new models, for various reasons: (a) in general, weaker localization implies better UV behaviour. Therefore, the class of renormalizable interactions in the string-localized has a chance to be larger than in the point-localized case; (b) for certain particle types, there are no point-localized (free) quantum fields - for example Anyons in d = 2 + 1, and Wigner's massless 'infinite spin' particles. For the latter, free string-localized quantum fields have been constructed; (c) in contrast to the point-localized case, string-localization admits covariant vector/tensor potentials for fotons and gravitons in a Hilbert space representation with positive energy. We shall present free string-localized quantum fields for various particle types, and some ideas about the perturbative construction of interacting string-localized fields. A central point will be an analogue of gauge theories, completely within a Hilbert space and without ghosts, trading gauge dependence with dependence on the direction of the localization string. In order to discuss renormalizability (item (a)), methods from microlocal analysis (wave front set and scaling degree) are needed. (author)

  8. A Platonic Sextet for Strings

    Science.gov (United States)

    Schaffer, Karl

    2012-01-01

    The use of traditional string figures by the Dr. Schaffer and Mr. Stern Dance Ensemble led to experimentation with polyhedral string constructions. This article presents a series of polyhedra made with six loops of three colors which sequence through all the Platonic Solids.

  9. Symmetry breaking in string theory

    International Nuclear Information System (INIS)

    Potting, R.

    1998-01-01

    A mechanism for a spontaneous breakdown of CPT symmetry appears in string theory, with possible implications for particle models. A realistic string theory might exhibit CPT violation at levels detectable in current or future experiments. A possible new mechanism for baryogenesis in the early Universe is also discussed

  10. Energy in a String Wave

    Science.gov (United States)

    Ng, Chiu-king

    2010-01-01

    When one end of a taut horizontal elastic string is shaken repeatedly up and down, a transverse wave (assume sine waveform) will be produced and travel along it. College students know this type of wave motion well. They know when the wave passes by, each element of the string will perform an oscillating up-down motion, which in mechanics is termed…

  11. String theory : physics or metaphysics?

    CERN Document Server

    Veneziano, Gabriele

    2010-01-01

    I will give arguments for why the enormous progress made during the last century on understanding elementary particles and their fundamental interactions suggests strings as the truly elementary constituents of Nature. I will then address the issue of whether the string paradigm can in principle be falsified or whether it should be considered as mere metaphysics.

  12. Differential formulation in string theories

    International Nuclear Information System (INIS)

    Guzzo, M.M.

    1987-01-01

    The equations of gauge invariance motion for theories of boson open strings and Neveu-Schwarz and Ramond superstring are derived. A construction for string theories using differential formalism, is introduced. The importance of BRST charge for constructing such theories and the necessity of introduction of auxiliary fields are verified. (M.C.K.) [pt

  13. Deformations of topological open strings

    NARCIS (Netherlands)

    Hofman, C.; Ma, Whee Ky

    Deformations of topological open string theories are described, with an emphasis on their algebraic structure. They are encoded in the mixed bulk-boundary correlators. They constitute the Hochschild complex of the open string algebra - the complex of multilinear maps on the boundary Hilbert space.

  14. Towards optimal packed string matching

    DEFF Research Database (Denmark)

    Ben-Kiki, Oren; Bille, Philip; Breslauer, Dany

    2014-01-01

    -size string-matching instruction wssm is available in contemporary commodity processors. The other word-size maximum-suffix instruction wslm is only required during the pattern pre-processing. Benchmarks show that our solution can be efficiently implemented, unlike some prior theoretical packed string...

  15. Experimenting with String Musical Instruments

    Science.gov (United States)

    LoPresto, Michael C.

    2012-01-01

    What follows are several investigations involving string musical instruments developed for and used in a "Science of Sound & Light" course. The experiments make use of a guitar, orchestral string instruments and data collection and graphing software. They are designed to provide students with concrete examples of how mathematical formulae, when…

  16. Progress in string theory research

    CERN Document Server

    2016-01-01

    At the first look, the String Theory seems just an interesting and non-trivial application of the quantum mechanics and the special relativity to vibrating strings. By itself, the quantization of relativistic strings does not call the attention of the particle physicist as a significant paradigm shift. However, when the string quantization is performed by applying the standard rules of the perturbative Quantum Field Theory, one discovers that the strings in certain states have the same physical properties as the gravity in the flat space-time. Chapter one of this book reviews the construction of the thermal bosonic string and D-brane in the framework of the Thermo Field Dynamics (TFD). It briefly recalls the wellknown light-cone quantization of the bosonic string in the conformal gauge in flat space-time, and gives a bird’s eye view of the fundamental concepts of the TFD. Chapter two examines a visual model inspired by string theory, on the system of interacting anyons. Chapter three investigate the late-ti...

  17. Gauge invariance of string fields

    International Nuclear Information System (INIS)

    Banks, T.; Peskin, M.E.

    1985-10-01

    Some work done to understand the appearance of gauge bosons and gravitons in string theories is reported. An action has been constructed for free (bosonic) string field theory which is invariant under an infinite set of gauge transformations which include Yang-Mills transformations and general coordinate transformations as special cases. 15 refs., 1 tab

  18. String dualities and superpotential

    International Nuclear Information System (INIS)

    Ha, Tae-Won

    2010-09-01

    The main objective of this thesis is the computation of the superpotential induced by D5- branes in the type IIB string theory and by five-branes in the heterotic string theory. Both superpotentials have the same functional form which is the chain integral of the holomorphic three-form. Using relative (co)homology we can unify the flux and brane superpotential. The chain integral can be seen as an example of the Abel-Jacobi map. We discuss many structures such as mixed Hodge structure which allows for the computation of Picard-Fuchs differential equations crucial for explicit computations. We blow up the Calabi-Yau threefold along the submanifold wrapped by the brane to obtain geometrically more appropriate configuration. The resulting geometry is non-Calabi-Yau and we have a canonically given divisor. This blown-up geometry makes it possible to restrict our attention to complex structure deformations. However, the direct computation is yet very difficult, thus the main tool for computation will be the lift of the brane configuration to a F-theory compactification. In F-theory, since complex structure, brane and, if present, bundlemoduli are all contained in the complex structure moduli space of the elliptic Calabi-Yau fourfold, the computation can be dramatically simplified. The heterotic/F-theory duality is extended to include the blow-up geometry and thereby used to give the blow-up geometry amore physical meaning. (orig.)

  19. String dualities and superpotential

    Energy Technology Data Exchange (ETDEWEB)

    Ha, Tae-Won

    2010-09-15

    The main objective of this thesis is the computation of the superpotential induced by D5- branes in the type IIB string theory and by five-branes in the heterotic string theory. Both superpotentials have the same functional form which is the chain integral of the holomorphic three-form. Using relative (co)homology we can unify the flux and brane superpotential. The chain integral can be seen as an example of the Abel-Jacobi map. We discuss many structures such as mixed Hodge structure which allows for the computation of Picard-Fuchs differential equations crucial for explicit computations. We blow up the Calabi-Yau threefold along the submanifold wrapped by the brane to obtain geometrically more appropriate configuration. The resulting geometry is non-Calabi-Yau and we have a canonically given divisor. This blown-up geometry makes it possible to restrict our attention to complex structure deformations. However, the direct computation is yet very difficult, thus the main tool for computation will be the lift of the brane configuration to a F-theory compactification. In F-theory, since complex structure, brane and, if present, bundlemoduli are all contained in the complex structure moduli space of the elliptic Calabi-Yau fourfold, the computation can be dramatically simplified. The heterotic/F-theory duality is extended to include the blow-up geometry and thereby used to give the blow-up geometry amore physical meaning. (orig.)

  20. Cosmology from string theory

    International Nuclear Information System (INIS)

    Anchordoqui, Luis; Nawata, Satoshi; Goldberg, Haim; Nunez, Carlos

    2007-01-01

    We explore the cosmological content of Salam-Sezgin six-dimensional supergravity, and find a solution to the field equations in qualitative agreement with observation of distant supernovae, primordial nucleosynthesis abundances, and recent measurements of the cosmic microwave background. The carrier of the acceleration in the present de Sitter epoch is a quintessence field slowly rolling down its exponential potential. Intrinsic to this model is a second modulus which is automatically stabilized and acts as a source of cold dark matter, with a mass proportional to an exponential function of the quintessence field (hence realizing varying mass particle models within a string context). However, any attempt to saturate the present cold dark matter component in this manner leads to unacceptable deviations from cosmological data--a numerical study reveals that this source can account for up to about 7% of the total cold dark matter budget. We also show that (1) the model will support a de Sitter energy in agreement with observation at the expense of a miniscule breaking of supersymmetry in the compact space; (2) variations in the fine structure constant are controlled by the stabilized modulus and are negligible; (3) ''fifth'' forces are carried by the stabilized modulus and are short range; (4) the long time behavior of the model in four dimensions is that of a Robertson-Walker universe with a constant expansion rate (w=-1/3). Finally, we present a string theory background by lifting our six-dimensional cosmological solution to ten dimensions

  1. Poisson hierarchy of discrete strings

    International Nuclear Information System (INIS)

    Ioannidou, Theodora; Niemi, Antti J.

    2016-01-01

    The Poisson geometry of a discrete string in three dimensional Euclidean space is investigated. For this the Frenet frames are converted into a spinorial representation, the discrete spinor Frenet equation is interpreted in terms of a transfer matrix formalism, and Poisson brackets are introduced in terms of the spinor components. The construction is then generalised, in a self-similar manner, into an infinite hierarchy of Poisson algebras. As an example, the classical Virasoro (Witt) algebra that determines reparametrisation diffeomorphism along a continuous string, is identified as a particular sub-algebra, in the hierarchy of the discrete string Poisson algebra. - Highlights: • Witt (classical Virasoro) algebra is derived in the case of discrete string. • Infinite dimensional hierarchy of Poisson bracket algebras is constructed for discrete strings. • Spinor representation of discrete Frenet equations is developed.

  2. Basic Concepts of String Theory

    CERN Document Server

    Blumenhagen, Ralph; Theisen, Stefan

    2013-01-01

    The purpose of this book is to thoroughly prepare the reader for research in string theory. It is intended as a textbook in the sense that, starting from the basics, the material is presented in a pedagogical and self-contained fashion. The emphasis is on the world-sheet perspective of closed strings and of open strings ending on D-branes, where two-dimensional conformal field theory is the main tool. Compactifications of string theory, with and without fluxes, and string dualities are also discussed from the space-time point of view, i.e. in geometric language. End-of-chapter references have been added to guide the reader intending to pursue further studies or to start research in the topics covered by this book.

  3. Strings, conformal fields and topology

    International Nuclear Information System (INIS)

    Kaku, Michio

    1991-01-01

    String Theory has advanced at an astonishing pace in the last few years, and this book aims to acquaint the reader with the most active topics of research in the field. Building on the foundations laid in his Introduction to Superstrings, Professor Kaku discusses such topics as the classification of conformal string theories, knot theory, the Yang-Baxter relation, quantum groups, the non-polynominal closed string field theory, matrix models, and topological field theory. Several chapters review the fundamentals of string theory, making the presentation of the material self-contained while keeping overlap with the earlier book to a minimum. The book conveys the vitality of current research in string theory and places readers at its forefront. (orig.) With 40 figs. in 50 parts

  4. Poisson hierarchy of discrete strings

    Energy Technology Data Exchange (ETDEWEB)

    Ioannidou, Theodora, E-mail: ti3@auth.gr [Faculty of Civil Engineering, School of Engineering, Aristotle University of Thessaloniki, 54249, Thessaloniki (Greece); Niemi, Antti J., E-mail: Antti.Niemi@physics.uu.se [Department of Physics and Astronomy, Uppsala University, P.O. Box 803, S-75108, Uppsala (Sweden); Laboratoire de Mathematiques et Physique Theorique CNRS UMR 6083, Fédération Denis Poisson, Université de Tours, Parc de Grandmont, F37200, Tours (France); Department of Physics, Beijing Institute of Technology, Haidian District, Beijing 100081 (China)

    2016-01-28

    The Poisson geometry of a discrete string in three dimensional Euclidean space is investigated. For this the Frenet frames are converted into a spinorial representation, the discrete spinor Frenet equation is interpreted in terms of a transfer matrix formalism, and Poisson brackets are introduced in terms of the spinor components. The construction is then generalised, in a self-similar manner, into an infinite hierarchy of Poisson algebras. As an example, the classical Virasoro (Witt) algebra that determines reparametrisation diffeomorphism along a continuous string, is identified as a particular sub-algebra, in the hierarchy of the discrete string Poisson algebra. - Highlights: • Witt (classical Virasoro) algebra is derived in the case of discrete string. • Infinite dimensional hierarchy of Poisson bracket algebras is constructed for discrete strings. • Spinor representation of discrete Frenet equations is developed.

  5. Basic concepts of string theory

    International Nuclear Information System (INIS)

    Blumenhagen, Ralph

    2013-01-01

    The purpose of this book is to thoroughly prepare the reader for research in string theory. It is intended as a textbook in the sense that, starting from the basics, the material is presented in a pedagogical and self-contained fashion. The emphasis is on the world-sheet perspective of closed strings and of open strings ending on D-branes, where two-dimensional conformal field theory is the main tool. Compactifications of string theory, with and without fluxes, and string dualities are also discussed from the space-time point of view, i.e. in geometric language. End-of-chapter references have been added to guide the reader intending to pursue further studies or to start research in the topics covered by this book.

  6. Testing string theory at LHC?

    CERN Multimedia

    CERN. Geneva

    2002-01-01

    A theory with such mathematical beauty cannot be wrong: this is one of the main arguments in favour of string theory, which unifies all known physical theories of fundamental interactions in a single coherent description of the universe. But no one has ever observed strings, not even indirectly, nor the space of extra dimensions where they live. However there are good reasons to believe that the 'hidden' dimensions of string theory may be much larger than what we thought in the past and that they may be within experimental reach in the near future - together with the strings themselves. In my talk, I will give an elementary introduction of string theory and describe the main experimental predictions.Organiser(s): Jasper Kirkby / EP DivisionNote: Tea & coffee will be served at 16.00 hrs.

  7. Neuronal growth on L- and D-cysteine self-assembled monolayers reveals neuronal chiral sensitivity.

    Science.gov (United States)

    Baranes, Koby; Moshe, Hagay; Alon, Noa; Schwartz, Shmulik; Shefi, Orit

    2014-05-21

    Studying the interaction between neuronal cells and chiral molecules is fundamental for the design of novel biomaterials and drugs. Chirality influences all biological processes that involve intermolecular interaction. One common method used to study cellular interactions with different enantiomeric targets is the use of chiral surfaces. Based on previous studies that demonstrated the importance of cysteine in the nervous system, we studied the effect of L- and D-cysteine on single neuronal growth. L-Cysteine, which normally functions as a neuromodulator or a neuroprotective antioxidant, causes damage at elevated levels, which may occur post trauma. In this study, we grew adult neurons in culture enriched with L- and D-cysteine as free compounds or as self-assembled monolayers of chiral surfaces and examined the effect on the neuronal morphology and adhesion. Notably, we have found that exposure to the L-cysteine enantiomer inhibited, and even prevented, neuronal attachment more severely than exposure to the D-cysteine enantiomer. Atop the L-cysteine surfaces, neuronal growth was reduced and degenerated. Since the cysteine molecules were attached to the surface via the thiol groups, the neuronal membrane was exposed to the molecular chiral site. Thus, our results have demonstrated high neuronal chiral sensitivity, revealing chiral surfaces as indirect regulators of neuronal cells and providing a reference for studying chiral drugs.

  8. Oriented open-closed string theory revisited

    International Nuclear Information System (INIS)

    Zwiebach, B.

    1998-01-01

    String theory on D-brane backgrounds is open-closed string theory. Given the relevance of this fact, we give details and elaborate upon our earlier construction of oriented open-closed string field theory. In order to incorporate explicitly closed strings, the classical sector of this theory is open strings with a homotopy associative A ∞ algebraic structure. We build a suitable Batalin-Vilkovisky algebra on moduli spaces of bordered Ricmann surfaces, the construction of which involves a few subtleties arising from the open string punctures and cyclicity conditions. All vertices coupling open and closed strings through disks are described explicitly. Subalgebras of the algebra of surfaces with boundaries are used to discuss symmetries of classical open string theory induced by the closed string sector, and to write classical open string field theory on general closed string backgrounds. We give a preliminary analysis of the ghost-dilaton theorem. copyright 1998 Academic Press, Inc

  9. A string theory which isn't about strings

    Science.gov (United States)

    Lee, Kanghoon; Rey, Soo-Jong; Rosabal, J. A.

    2017-11-01

    Quantization of closed string proceeds with a suitable choice of worldsheet vacuum. A priori, the vacuum may be chosen independently for left-moving and right-moving sectors. We construct ab initio quantized bosonic string theory with left-right asymmetric worldsheet vacuum and explore its consequences and implications. We critically examine the validity of new vacuum and carry out first-quantization using standard operator formalism. Remarkably, the string spectrum consists only of a finite number of degrees of freedom: string gravity (massless spin-two, Kalb-Ramond and dilaton fields) and two massive spin-two Fierz-Pauli fields. The massive spin-two fields have negative norm, opposite mass-squared, and provides a Lee-Wick type extension of string gravity. We compute two physical observables: tree-level scattering amplitudes and one-loop cosmological constant. Scattering amplitude of four dilatons is shown to be a rational function of kinematic invariants, and in D = 26 factorizes into contributions of massless spin-two and a pair of massive spin-two fields. The string one loop partition function is shown to perfectly agree with one loop Feynman diagram of string gravity and two massive spin-two fields. In particular, it does not exhibit modular invariance. We critically compare our construction with recent studies and contrast differences.

  10. Conformal techniques in string theory and string field theory

    International Nuclear Information System (INIS)

    Giddings, S.B.

    1987-01-01

    The application of some conformal and Riemann surface techniques to string theory and string field theory is described. First a brief review of Riemann surface techniques and of the Polyakov approach to string theory is presented. This is followed by a discussion of some features of string field theory and of its Feynman rules. Specifically, it is shown that the Feynman diagrams for Witten's string field theory respect modular invariance, and in particular give a triangulation of moduli space. The Polyakov formalism is then used to derive the Feynman rules that should follow from this theory upon gauge-fixing. It should also be possible to apply this derivation to deduce the Feynman rules for other gauge-fixed string field theories. Following this, Riemann surface techniques are turned to the problem of proving the equivalence of the Polyakov and light-cone formalisms. It is first shown that the light-cone diagrams triangulate moduli space. Then the Polyakov measure is worked out for these diagrams, and shown to equal that deduced from the light-cone gauge fixed formalism. Also presented is a short description of the comparison of physical states in the two formalisms. The equivalence of the two formalisms in particular constitutes a proof of the unitarity of the Polyakov framework for the closed bosonic string

  11. String model of elementary particles

    International Nuclear Information System (INIS)

    Kikkawa, Keiji

    1975-01-01

    Recent development of the models of elementary particles is described. The principal features of elementary particle physics can be expressed by quark model, mass spectrum, the Regge behavior of scattering amplitude, and duality. Venezians showed in 1968 that the B function can express these features. From the analysis of mass spectrum, the string model was introduced. The quantization of the string is performed with the same procedure as the ordinary quantum mechanics. The motion of the string is determined by the Nambu-Goto action integral, and the Schroedinger equation is obtained. Mass spectrum from the string model was same as that from the duality model such as Veneziano model. The interaction between strings can be introduced, and the Lagrangian can be formulated. The relation between the string model and the duality model has been studied. The string model is the first theory of non-local field, and the further development is attractive. The relation between this model and the quark model is still not clear. (Kato, T.)

  12. String bit models for superstring

    International Nuclear Information System (INIS)

    Bergman, O.; Thorn, C.B.

    1995-01-01

    The authors extend the model of string as a polymer of string bits to the case of superstring. They mainly concentrate on type II-B superstring, with some discussion of the obstacles presented by not II-B superstring, together with possible strategies for surmounting them. As with previous work on bosonic string work within the light-cone gauge. The bit model possesses a good deal less symmetry than the continuous string theory. For one thing, the bit model is formulated as a Galilei invariant theory in (D - 2) + 1 dimensional space-time. This means that Poincare invariance is reduced to the Galilei subgroup in D - 2 space dimensions. Naturally the supersymmetry present in the bit model is likewise dramatically reduced. Continuous string can arise in the bit models with the formation of infinitely long polymers of string bits. Under the right circumstances (at the critical dimension) these polymers can behave as string moving in D dimensional space-time enjoying the full N = 2 Poincare supersymmetric dynamics of type II-B superstring

  13. String bit models for superstring

    Energy Technology Data Exchange (ETDEWEB)

    Bergman, O.; Thorn, C.B.

    1995-12-31

    The authors extend the model of string as a polymer of string bits to the case of superstring. They mainly concentrate on type II-B superstring, with some discussion of the obstacles presented by not II-B superstring, together with possible strategies for surmounting them. As with previous work on bosonic string work within the light-cone gauge. The bit model possesses a good deal less symmetry than the continuous string theory. For one thing, the bit model is formulated as a Galilei invariant theory in (D {minus} 2) + 1 dimensional space-time. This means that Poincare invariance is reduced to the Galilei subgroup in D {minus} 2 space dimensions. Naturally the supersymmetry present in the bit model is likewise dramatically reduced. Continuous string can arise in the bit models with the formation of infinitely long polymers of string bits. Under the right circumstances (at the critical dimension) these polymers can behave as string moving in D dimensional space-time enjoying the full N = 2 Poincare supersymmetric dynamics of type II-B superstring.

  14. Fermions on the electroweak string

    CERN Document Server

    Moreno, J M; Quirós, Mariano; Moreno, J M; Oaknin, D H; Quiros, M

    1995-01-01

    We construct a simple class of exact solutions of the electroweak theory including the naked Z--string and fermion fields. It consists in the Z--string configuration (\\phi,Z_\\theta), the {\\it time} and z components of the neutral gauge bosons (Z_{0,3},A_{0,3}) and a fermion condensate (lepton or quark) zero mode. The Z--string is not altered (no feed back from the rest of fields on the Z--string) while fermion condensates are zero modes of the Dirac equation in the presence of the Z--string background (no feed back from the {\\it time} and z components of the neutral gauge bosons on the fermion fields). For the case of the n--vortex Z--string the number of zero modes found for charged leptons and quarks is (according to previous results by Jackiw and Rossi) equal to |n|, while for (massless) neutrinos is |n|-1. The presence of fermion fields in its core make the obtained configuration a superconducting string, but their presence (as well as that of Z_{0,3},A_{0,3}) does not enhance the stability of the Z--stri...

  15. Gravity and strings

    CERN Document Server

    Ortín, Tomás

    2015-01-01

    Self-contained and comprehensive, this definitive new edition of Gravity and Strings is a unique resource for graduate students and researchers in theoretical physics. From basic differential geometry through to the construction and study of black-hole and black-brane solutions in quantum gravity - via all the intermediate stages - this book provides a complete overview of the intersection of gravity, supergravity, and superstrings. Now fully revised, this second edition covers an extensive array of topics, including new material on non-linear electric-magnetic duality, the electric-tensor formalism, matter-coupled supergravity, supersymmetric solutions, the geometries of scalar manifolds appearing in 4- and 5-dimensional supergravities, and much more. Covering reviews of important solutions and numerous solution-generating techniques, and accompanied by an exhaustive index and bibliography, this is an exceptional reference work.

  16. Fingerprints in compressed strings

    DEFF Research Database (Denmark)

    Bille, Philip; Gørtz, Inge Li; Cording, Patrick Hagge

    2017-01-01

    In this paper we show how to construct a data structure for a string S of size N compressed into a context-free grammar of size n that supports efficient Karp–Rabin fingerprint queries to any substring of S. That is, given indices i and j, the answer to a query is the fingerprint of the substring S......[i,j]. We present the first O(n) space data structures that answer fingerprint queries without decompressing any characters. For Straight Line Programs (SLP) we get O(log⁡N) query time, and for Linear SLPs (an SLP derivative that captures LZ78 compression and its variations) we get O(log⁡log⁡N) query time...

  17. Field theory and strings

    International Nuclear Information System (INIS)

    Bonara, L.; Cotta-Ramusino, P.; Rinaldi, M.

    1987-01-01

    It is well-known that type I and heterotic superstring theories have a zero mass spectrum which correspond to the field content of N=1 supergravity theory coupled to supersymmetric Yang-Mills theory in 10-D. The authors study the field theory ''per se'', in the hope that simple consistency requirements will determine the theory completely once one knows the field content inherited from string theory. The simplest consistency requirements are: N=1 supersymmetry; and absence of chiral anomalies. This is what the authors discuss in this paper here leaving undetermined the question of the range of validity of the resulting field theory. As is known, a model of N=1 supergravity (SUGRA) coupled to supersymmetric Yang-Mills (SYM) theory was known in the form given by Chapline and Manton. The coupling of SUGRA to SYM was determined by the definition of the ''field strength'' 3-form H in this paper

  18. Dynamical evolution of cosmic strings

    International Nuclear Information System (INIS)

    Bouchet, F.R.

    1988-01-01

    The author have studied by means of numerical simulations the dynamical evolution of a network of cosmic strings, both in the radiation and matter era. Our basic conclusion is that a scaling solution exists, i.e., the string energy density evolves as t -2 . This means that the process by which long strings dump their energy into closed loops (which can gravitationally radiate away) is efficient enough to prevent the string domination over other forms of energy. This conclusion does not depend on the initial string energy density, nor on the various numerical parameters. On the other hand, the generated spectrum of loop sizes does depend on the value of our numerical lower cutoff (i.e., the minimum length of loop we allow to be chopped off the network). Furthermore, the network evolution is very different from what was assumed before), namely the creation of a few horizon sized loops per horizon volume and per hubble time, which subsequently fragment into about 10 smaller daughter loops. Rather, many tiny loops are directly cut from the network of infinite strings, and it appears that the only fundamental scale (the horizon) has been lost. This is probably because a fundamental ingredient had been overlooked, namely the kinks. These kinks are created in pairs at each intercommutation, and very rapidly, the long strings appear to be very kinky. Thus the number of long strings per horizon is still of the order of a few, but their total length is fairly large. Furthermore, a large number of kinks favors the formation of small loops, and their sizes might well be governed by the kink density along the long strings. Finally, we computed the two-point correlation function of the loops and found significant differences from the work of Turok

  19. Casimir energy of a nonuniform string

    Science.gov (United States)

    Hadasz, L.; Lambiase, G.; Nesterenko, V. V.

    2000-07-01

    The Casimir energy of a nonuniform string built up from two pieces with different speeds of sound is calculated. A standard procedure of subtracting the energy of an infinite uniform string is applied, the subtraction being interpreted as the renormalization of the string tension. It is shown that in the case of a homogeneous string this method is completely equivalent to zeta renormalization.

  20. Test particle trajectories near cosmic strings

    Indian Academy of Sciences (India)

    We present a detailed analysis of the motion of test particle in the gravitational field of cosmic strings in different situations using the Hamilton–Jacobi (H–J) formalism. We have discussed the trajectories near static cosmic string, cosmic string in Brans–Dicke theory and cosmic string in dilaton gravity.

  1. String Formatting Considered Harmful for Novice Programmers

    Science.gov (United States)

    Hughes, Michael C.; Jadud, Matthew C.; Rodrigo, Ma. Mercedes T.

    2010-01-01

    In Java, "System.out.printf" and "String.format" consume a specialised kind of string commonly known as a format string. In our study of first-year students at the Ateneo de Manila University, we discovered that format strings present a substantial challenge for novice programmers. Focusing on their first laboratory we found…

  2. M-strings, Elliptic Genera and N=4 String Amplitudes

    CERN Document Server

    Hohenegger, Stefan

    2014-01-01

    We study mass-deformed N=2 gauge theories from various points of view. Their partition functions can be computed via three dual approaches: firstly, (p,q)-brane webs in type II string theory using Nekrasov's instanton calculus, secondly, the (refined) topological string using the topological vertex formalism and thirdly, M theory via the elliptic genus of certain M-strings configurations. We argue for a large class of theories that these approaches yield the same gauge theory partition function which we study in detail. To make their modular properties more tangible, we consider a fourth approach by connecting the partition function to the equivariant elliptic genus of R^4 through a (singular) theta-transform. This form appears naturally as a specific class of one-loop scattering amplitudes in type II string theory on T^2, which we calculate explicitly.

  3. Covariant N-string amplitude

    International Nuclear Information System (INIS)

    Di Vecchia, P.; Sciuto, S.; Nakayama, R.; Petersen, J.L.; Sidenius, J.R.

    1986-11-01

    The BRST-invariant N-Reggeon vertex (for the bosonic string) previously given by us in the operator formulation is considered in more detail. In particular we present a direct derivation from the string path integral. Several crucial symmetry properties found a posteriori before, become a priori clearer in this formulation. A number of delicate points related to zero modes, cut off procedures and normal ordering prescriptions are treated in some detail. The old technique of letting the string field acquire a small dimension ε/2 → 0 + is found especially elegant. (orig.)

  4. Plucked Strings and the Harpsichord

    Science.gov (United States)

    GIORDANO, N.; WINANS, J. P.

    1999-07-01

    The excitation of a harpsichord string when it is set into motion, i.e., plucked, by a plectrum is studied. We find that the amplitude of the resulting string vibration is approximately independent of the velocity with which the key is depressed. This result is in accord with conventional wisdom, but at odds with a recent theoretical model. A more realistic theoretical treatment of the plucking process is then described, and shown to be consistent with our measurements. The experiments reveal several other interesting aspects of the plectrum-string interaction.

  5. Worldsheet geometries of ambitwistor string

    Energy Technology Data Exchange (ETDEWEB)

    Ohmori, Kantaro [Department of Physics, the University of Tokyo,Hongo, Bunkyo-ku, Tokyo 133-0022 (Japan)

    2015-06-12

    Mason and Skinner proposed the ambitwistor string theory which directly reproduces the formulas for the amplitudes of massless particles proposed by Cachazo, He and Yuan. In this paper we discuss geometries of the moduli space of worldsheets associated to the bosonic or the RNS ambitwistor string. Further, we investigate the factorization properties of the amplitudes when an internal momentum is near on-shell in the abstract CFT language. Along the way, we propose the existence of the ambitwistor strings with three or four fermionic worldsheet currents.

  6. Spin chain for quantum strings

    International Nuclear Information System (INIS)

    Beisert, N.

    2005-01-01

    We review and compare the integrable structures in N=4 gauge theory and string theory on AdS 5 x S 5 . Recently, Bethe ansaetze for gauge theory/weak coupling and string theory/strong coupling were proposed to describe scaling dimensions in the su(2) subsector. Here we investigate the Bethe equations for quantum string theory, naively extrapolated to weak coupling. Excitingly, we find a spin chain Hamiltonian similar, but not equal, to the gauge theory dilatation operator. (Abstract Copyright [2005], Wiley Periodicals, Inc.)

  7. Geometry, topology, and string theory

    Energy Technology Data Exchange (ETDEWEB)

    Varadarajan, Uday [Univ. of California, Berkeley, CA (United States)

    2003-01-01

    A variety of scenarios are considered which shed light upon the uses and limitations of classical geometric and topological notions in string theory. The primary focus is on situations in which D-brane or string probes of a given classical space-time see the geometry quite differently than one might naively expect. In particular, situations in which extra dimensions, non-commutative geometries as well as other non-local structures emerge are explored in detail. Further, a preliminary exploration of such issues in Lorentzian space-times with non-trivial causal structures within string theory is initiated.

  8. Geometry, topology, and string theory

    International Nuclear Information System (INIS)

    Varadarajan, Uday

    2003-01-01

    A variety of scenarios are considered which shed light upon the uses and limitations of classical geometric and topological notions in string theory. The primary focus is on situations in which D-brane or string probes of a given classical space-time see the geometry quite differently than one might naively expect. In particular, situations in which extra dimensions, non-commutative geometries as well as other non-local structures emerge are explored in detail. Further, a preliminary exploration of such issues in Lorentzian space-times with non-trivial causal structures within string theory is initiated

  9. Isolation and molecular characterization of cathepsin L-like cysteine protease cDNAs from Western flower thrips (Frankliniella occidentalis)

    NARCIS (Netherlands)

    Kuipers, A.G.J.; Jongsma, M.A.

    2004-01-01

    Cysteine proteases are predominant in thrips guts (TGs) and, therefore, a suitable target for selecting effective protease inhibitors against western flower thrips (Frankliniella occidentalis). We report the isolation of four full-length cysteine protease cDNA clones from thrips in a two-step PCR

  10. String cosmology modern string theory concepts from the cosmic structure

    CERN Document Server

    2009-01-01

    The field of string cosmology has matured considerably over the past few years, attracting many new adherents to this multidisciplinary Field. This book fills a critical gap by bringing together strains of current research into one single volume. The resulting collection of selected articles presents the latest, ongoing results from renowned experts currently working in the field. This offers the possibility for practitioners to become conversant with many different aspects of string cosmology

  11. String cosmology. Large-field inflation in string theory

    International Nuclear Information System (INIS)

    Westphal, Alexander

    2014-09-01

    This is a short review of string cosmology. We wish to connect string-scale physics as closely as possible to observables accessible to current or near-future experiments. Our possible best hope to do so is a description of inflation in string theory. The energy scale of inflation can be as high as that of Grand Unification (GUT). If this is the case, this is the closest we can possibly get in energy scales to string-scale physics. Hence, GUT-scale inflation may be our best candidate phenomenon to preserve traces of string-scale dynamics. Our chance to look for such traces is the primordial gravitational wave, or tensor mode signal produced during inflation. For GUT-scale inflation this is strong enough to be potentially visible as a B-mode polarization of the cosmic microwave background (CMB). Moreover, a GUT-scale inflation model has a trans-Planckian excursion of the inflaton scalar field during the observable amount of inflation. Such large-field models of inflation have a clear need for symmetry protection against quantum corrections. This makes them ideal candidates for a description in a candidate fundamental theory like string theory. At the same time the need of large-field inflation models for UV completion makes them particularly susceptible to preserve imprints of their string-scale dynamics in the inflationary observables, the spectral index n s and the fractional tensor mode power r. Hence, we focus this review on axion monodromy inflation as a mechanism of large-field inflation in string theory.

  12. Allicin and derivates are cysteine protease inhibitors with antiparasitic activity.

    Science.gov (United States)

    Waag, Thilo; Gelhaus, Christoph; Rath, Jennifer; Stich, August; Leippe, Matthias; Schirmeister, Tanja

    2010-09-15

    Allicin and derivatives thereof inhibit the CAC1 cysteine proteases falcipain 2, rhodesain, cathepsin B and L in the low micromolar range. The structure-activity relationship revealed that only derivatives with primary carbon atom in vicinity to the thiosulfinate sulfur atom attacked by the active-site Cys residue are active against the target enzymes. Some compounds also show potent antiparasitic activity against Plasmodium falciparum and Trypanosoma brucei brucei. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

  13. Charting the Landscape of Supercritical String Theory

    International Nuclear Information System (INIS)

    Hellerman, Simeon; Swanson, Ian

    2007-01-01

    Special solutions of string theory in supercritical dimensions can interpolate in time between theories with different numbers of spacetime dimensions and different amounts of world sheet supersymmetry. These solutions connect supercritical string theories to the more familiar string duality web in ten dimensions and provide a precise link between supersymmetric and purely bosonic string theories. Dimension quenching and c duality appear to be natural concepts in string theory, giving rise to large networks of interconnected theories

  14. String and Sticky Tape Experiments.

    Science.gov (United States)

    Edge, R. D., Ed.

    1979-01-01

    Explains how to demonstrate the fundamentals of one dimensional kinematics such as Newton's third law of motion, and collision between bodies, using simple materials of marbles, strings, sticky tape, drinking straws, and rubber bands. (GA)

  15. String theory or field theory?

    International Nuclear Information System (INIS)

    Marshakov, A.V.

    2002-01-01

    The status of string theory is reviewed, and major recent developments - especially those in going beyond perturbation theory in the string theory and quantum field theory frameworks - are analyzed. This analysis helps better understand the role and place of experimental phenomena, it is emphasized that there are some insurmountable problems inherent in it - notably the impossibility to formulate the quantum theory of gravity on its basis - which prevent it from being a fundamental physical theory of the world of microscopic distances. It is this task, the creation of such a theory, which string theory, currently far from completion, is expected to solve. In spite of its somewhat vague current form, string theory has already led to a number of serious results and greatly contributed to progress in the understanding of quantum field theory. It is these developments, which are our concern in this review [ru

  16. String moduli inflation. An overview

    Energy Technology Data Exchange (ETDEWEB)

    Cicoli, Michele [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Quevedo, Fernando [Cambridge Univ. (United Kingdom). DAMTP/CMS; Abdus Salam International Centre for Theoretical Physics, Trieste (Italy)

    2011-06-15

    We present an overview of inflationary models derived from string theory focusing mostly on closed string moduli as inflatons. After a detailed discussion of the {eta}-problem and different approaches to address it, we describe possible ways to obtain a de Sitter vacuum with all closed string moduli stabilised. We then look for inflationary directions and present some of the most promising scenarios where the inflatons are either the real or the imaginary part of Kaehler moduli. We pay particular attention on extracting potential observable implications, showing how most of the scenarios predict negligible gravitational waves and could therefore be ruled out by the Planck satellite. We conclude by briefly mentioning some open challenges in string cosmology beyond deriving just inflation. (orig.)

  17. Spin chains and string theory.

    Science.gov (United States)

    Kruczenski, Martin

    2004-10-15

    Recently, an important test of the anti de Sitter/conformal field theory correspondence has been done using rotating strings with two angular momenta. We show that such a test can be described more generally as the agreement between two actions: one a low energy description of a spin chain appearing in the field theory side, and the other a limit of the string action in AdS5xS5. This gives a map between the mean value of the spin in the boundary theory and the position of the string in the bulk, and shows how a string action can emerge from a gauge theory in the large-N limit.

  18. Pattern recognition and string matching

    CERN Document Server

    Cheng, Xiuzhen

    2002-01-01

    The research and development of pattern recognition have proven to be of importance in science, technology, and human activity. Many useful concepts and tools from different disciplines have been employed in pattern recognition. Among them is string matching, which receives much theoretical and practical attention. String matching is also an important topic in combinatorial optimization. This book is devoted to recent advances in pattern recognition and string matching. It consists of twenty eight chapters written by different authors, addressing a broad range of topics such as those from classifica­ tion, matching, mining, feature selection, and applications. Each chapter is self-contained, and presents either novel methodological approaches or applications of existing theories and techniques. The aim, intent, and motivation for publishing this book is to pro­ vide a reference tool for the increasing number of readers who depend upon pattern recognition or string matching in some way. This includes student...

  19. String moduli inflation. An overview

    International Nuclear Information System (INIS)

    Cicoli, Michele; Quevedo, Fernando

    2011-06-01

    We present an overview of inflationary models derived from string theory focusing mostly on closed string moduli as inflatons. After a detailed discussion of the η-problem and different approaches to address it, we describe possible ways to obtain a de Sitter vacuum with all closed string moduli stabilised. We then look for inflationary directions and present some of the most promising scenarios where the inflatons are either the real or the imaginary part of Kaehler moduli. We pay particular attention on extracting potential observable implications, showing how most of the scenarios predict negligible gravitational waves and could therefore be ruled out by the Planck satellite. We conclude by briefly mentioning some open challenges in string cosmology beyond deriving just inflation. (orig.)

  20. String Formation Beyond Leading Colour

    CERN Document Server

    Christiansen, Jesper R.

    2015-08-03

    We present a new model for the hadronisation of multi-parton systems, in which colour correlations beyond leading $N_C$ are allowed to influence the formation of confining potentials (strings). The multiplet structure of $SU(3)$ is combined with a minimisation of the string potential energy, to decide between which partons strings should form, allowing also for "baryonic" configurations (e.g., two colours can combine coherently to form an anticolour). In $e^+e^-$collisions, modifications to the leading-colour picture are small, suppressed by both colour and kinematics factors. But in $pp$ collisions, multi-parton interactions increase the number of possible subleading connections, counteracting their naive $1/N_C^2$ suppression. Moreover, those that reduce the overall string lengths are kinematically favoured. The model, which we have implemented in the PYTHIA 8 generator, is capable of reaching agreement not only with the important $\\left(n_\\mathrm{charged})$ distribution but also with measured rates (and ra...

  1. Strings in the abelized picture

    International Nuclear Information System (INIS)

    Embacher, F.

    1990-01-01

    The transformation properties of the bosonic string variables under the recently discovered abelizing operator are exhibited. The intimate relation of this operator to the light-cone gauge condition is illustrated for the classical string. As an application of the formalism, the derivation of the BRST cohomology by the method of Freemann and Olive is carried over to the abelized picture, where it takes a particularly simple from. (orig.)

  2. The W3 string spectrum

    International Nuclear Information System (INIS)

    Pope, C.N.; Stelle, K.S.

    1991-08-01

    We study the spectrum of W 3 strings. In particular, we show that for appropriately chosen space-time signature, one of the scalar fields is singled out be the spin-3 constraint and is ''frozen'': no creation operators from it can appear in physical states and the corresponding momentum must assume a specific fixed value. The remaining theory is unitary and resembles an ordinary string theory in d contains 26 with anomalies cancelled by appropriate background charges. (author). 8 refs

  3. Cooldown of superconducting magnet strings

    International Nuclear Information System (INIS)

    Yuecel, A.; Carcagno, R.H.

    1995-01-01

    A numerical model for the cooldown of the superconducting magnet strings in the Accelerator System String Test (ASST) Facility at the Superconducting Super Collider (SSC) Laboratory is presented. Numerical results are compared with experimental data from the ASST test runs. Agreement between the numerical predictions and experiments is very good over the entire range from room temperature to liquid helium temperatures. The model can be readily adapted to predict the cooldown and warmup behavior of other superconducting magnets or cold masses

  4. Strings in the abelized picture

    International Nuclear Information System (INIS)

    Embacher, F.

    1990-01-01

    The transformation properties of the bosonic string variables under the recently discovered abelizing operator are exhibited. The intimate relation of this operator to the light-cone gauge condition is illustrated for the classical string. As an application of the formalism, the derivation of the BRST cohomology by the method of Freeman and Olive is carried over to the abelized picture, where it takes a particulary simple form. 14 refs. (Author)

  5. An introduction to string theory

    OpenAIRE

    West, Peter C

    1989-01-01

    These notes are based on lectures given by Michael Green during Part III of the Mathematics Tripos (the Certificate for Advanced Study in Mathematics) in the Spring of 2003. The course provided an introduction to string theory, focussing on the Bosonic string, but treating the superstring as well. A background in quantum field theory and general relativity is assumed. Some background in particle physics, group theory and conformal field theory is useful, though not essential. A number of appe...

  6. Black strings and classical hair

    International Nuclear Information System (INIS)

    Horowitz, G.T.; Yang, H.

    1997-01-01

    We examine the geometry near the event horizon of a family of black string solutions with traveling waves. It has previously been shown that the metric is continuous there. Contrary to expectations, we find that the geometry is not smooth, and the horizon becomes singular whenever a wave is present. Both five-dimensional and six-dimensional black strings are considered with similar results. copyright 1997 The American Physical Society

  7. On Field Theory of Open Strings, Tachyon Condensation and Closed Strings

    OpenAIRE

    Shatashvili, Samson L.

    2001-01-01

    I review the physical properties of different vacua in the background independent open string field theory. Talk presented at Strings 2001, Mumbai, India, http://theory.theory.tifr.res.in/strings/Proceedings/#sha-s.

  8. Fast searching in packed strings

    DEFF Research Database (Denmark)

    Bille, Philip

    2011-01-01

    Given strings P and Q the (exact) string matching problem is to find all positions of substrings in Q matching P. The classical Knuth–Morris–Pratt algorithm [SIAM J. Comput. 6 (2) (1977) 323–350] solves the string matching problem in linear time which is optimal if we can only read one character...... at the time. However, most strings are stored in a computer in a packed representation with several characters in a single word, giving us the opportunity to read multiple characters simultaneously. In this paper we study the worst-case complexity of string matching on strings given in packed representation....... Let m⩽n be the lengths P and Q, respectively, and let σ denote the size of the alphabet. On a standard unit-cost word-RAM with logarithmic word size we present an algorithm using timeO(nlogσn+m+occ). Here occ is the number of occurrences of P in Q. For m=o(n) this improves the O(n) bound of the Knuth...

  9. Experimental observation of Bethe strings

    Science.gov (United States)

    Wang, Zhe; Wu, Jianda; Yang, Wang; Bera, Anup Kumar; Kamenskyi, Dmytro; Islam, A. T. M. Nazmul; Xu, Shenglong; Law, Joseph Matthew; Lake, Bella; Wu, Congjun; Loidl, Alois

    2018-02-01

    Almost a century ago, string states—complex bound states of magnetic excitations—were predicted to exist in one-dimensional quantum magnets. However, despite many theoretical studies, the experimental realization and identification of string states in a condensed-matter system have yet to be achieved. Here we use high-resolution terahertz spectroscopy to resolve string states in the antiferromagnetic Heisenberg-Ising chain SrCo2V2O8 in strong longitudinal magnetic fields. In the field-induced quantum-critical regime, we identify strings and fractional magnetic excitations that are accurately described by the Bethe ansatz. Close to quantum criticality, the string excitations govern the quantum spin dynamics, whereas the fractional excitations, which are dominant at low energies, reflect the antiferromagnetic quantum fluctuations. Today, Bethe’s result is important not only in the field of quantum magnetism but also more broadly, including in the study of cold atoms and in string theory; hence, we anticipate that our work will shed light on the study of complex many-body systems in general.

  10. Dynamics of strings between walls

    International Nuclear Information System (INIS)

    Eto, Minoru; Fujimori, Toshiaki; Nagashima, Takayuki; Nitta, Muneto; Ohashi, Keisuke; Sakai, Norisuke

    2009-01-01

    Configurations of vortex strings stretched between or ending on domain walls were previously found to be 1/4 Bogomol'nyi-Prasad-Sommerfield (BPS) states in N=2 supersymmetric gauge theories in 3+1 dimensions. Among zero modes of string positions, the center of mass of strings in each region between two adjacent domain walls is shown to be non-normalizable whereas the rests are normalizable. We study dynamics of vortex strings stretched between separated domain walls by using two methods, the moduli space (geodesic) approximation of full 1/4 BPS states and the charged particle approximation for string end points in the wall effective action. In the first method we explicitly obtain the effective Lagrangian in the strong coupling limit, which is written in terms of hypergeometric functions, and find the 90 deg. scattering for head-on collision. In the second method the domain wall effective action is assumed to be U(1) N gauge theory, and we find a good agreement between two methods for well-separated strings.

  11. Is the string theory doomed?

    International Nuclear Information System (INIS)

    Le Meur, H.; Daninos, F.; Bachas, C.

    2007-01-01

    Since its beginning, in the sixties, the string theory has succeeded in overcoming a lot of theoretical difficulties but now the complete absence of experimental validation entertains doubts about its ability to represent the real world and questions its hegemony in today's theoretical physics. Other space-time theories like the twistors, or the non-commutative geometry, or the loop quantum gravity, or the causal dynamics triangulation might begin receiving more attention. Despite all that, the string theory can be given credit for 4 achievements. First, the string theory has provided a consistent quantum description of gravity. Secondly, the string theory has built a theoretical frame that has allowed the unification of the 4 basic interactions. Thirdly, the string theory applied to astrophysics issues has demonstrated that the evaporation of a black hole does not necessarily lead to a loss of information which comforts the universality of the conservation of the quantity of information in any system and as a consequence put a fatal blow to the so-called paradox observed in black holes. Fourthly, the string theory has given a new and original meaning on the true nature of space-time. (A.C.)

  12. String theory on the edge

    International Nuclear Information System (INIS)

    Thorlacius, L.

    1989-01-01

    Open string vacuum configurations are described in terms of a one-dimensional field theory on the worldsheet boundary. The one-dimensional path integral has direct physical interpretation as a source term for closed string fields. This means that the vacuum divergences (Mobius infinities) of the path integral must be renormalized correctly. The author shows that reparametrization invariance Ward identities, apart from specifying the equations of motion of spacetime background gauge fields, also serve to fix the renormalization scheme of the vacuum divergences. He argues that vacuum configurations of open strings correspond to Caldeira-Leggett models of dissipative quantum mechanics (DQM) evaluated at a delocalization critical point. This connection reveals that critical DQM will manifest reparametrization invariance (inherited from the conformal invariance of string theory) rather than just scale invariance. This connection should open up new ways of constructing analytic and approximate solutions of open string theory (in particular, topological solitons such as monopoles and instantons). Type I superstring theory gives rise to a supersymmetric boundary field theory. Bose-Fermi cancellation eliminates vacuum divergences but the one-loop beta function remains the same as in the bosonic theory. Reparametrization invariance Ward identities dictate a boundary state normalization which yields consistent string-loop corrections to spacetime equations of motion, in both the periodic and anti-periodic fermion sectors

  13. Chern-Simons couplings for dielectric F-strings in matrix string theory

    International Nuclear Information System (INIS)

    Brecher, Dominic; Janssen, Bert; Lozano, Yolanda

    2002-01-01

    We compute the non-abelian couplings in the Chern-Simons action for a set of coinciding fundamental strings in both the type IIA and type IIB Matrix string theories. Starting from Matrix theory in a weakly curved background, we construct the linear couplings of closed string fields to type IIA Matrix strings. Further dualities give a type IIB Matrix string theory and a type IIA theory of Matrix strings with winding. (Abstract Copyright[2002], Wiley Periodicals, Inc.)

  14. New expressions for string loop amplitudes leading to an ultra-simple conception of string dynamics

    International Nuclear Information System (INIS)

    Chan Hongmo; Tsou Sheungtsun; Bordes, J.; Nellen, L.

    1990-11-01

    New expressions are derived for string loop amplitudes as overlap integrals of string wave functionals. They are shown to take the form of exchange terms coming from the Bose-Einstein symmetrisation between string segments. One is thus led to the ultra-simple conception that string theory is basically free, and that 'string interactions' are due merely to the fact that strings are composite objects with Bose-Einstein segments as constituents. (author)

  15. Crystallization and preliminary X-ray diffraction analyses of pseudechetoxin and pseudecin, two snake-venom cysteine-rich secretory proteins that target cyclic nucleotide-gated ion channels

    International Nuclear Information System (INIS)

    Suzuki, Nobuhiro; Yamazaki, Yasuo; Fujimoto, Zui; Morita, Takashi; Mizuno, Hiroshi

    2005-01-01

    Crystals of pseudechetoxin and pseudecin, potent peptidic inhibitors of cyclic nucleotide-gated ion channels, have been prepared and X-ray diffraction data have been collected to 2.25 and 1.90 Å resolution, respectively. Cyclic nucleotide-gated (CNG) ion channels play pivotal roles in sensory transduction of retinal and olfactory neurons. The elapid snake toxins pseudechetoxin (PsTx) and pseudecin (Pdc) are the only known protein blockers of CNG channels. These toxins are structurally classified as cysteine-rich secretory proteins and exhibit structural features that are quite distinct from those of other known small peptidic channel blockers. This article describes the crystallization and preliminary X-ray diffraction analyses of these toxins. Crystals of PsTx belonged to space group P2 1 2 1 2 1 , with unit-cell parameters a = 60.30, b = 61.59, c = 251.69 Å, and diffraction data were collected to 2.25 Å resolution. Crystals of Pdc also belonged to space group P2 1 2 1 2 1 , with similar unit-cell parameters a = 60.71, b = 61.67, c = 251.22 Å, and diffraction data were collected to 1.90 Å resolution

  16. Gravity from strings

    International Nuclear Information System (INIS)

    Deser, S.

    1987-01-01

    We obtain the Einstein action plus quadratic curvature corrections generated by closed bosonic, heterotic and supersymmetric strings by matching the four-graviton amplitude (to first order in the slope parameter and fourth power of momenta) with an effective local gravitational action. The resulting corrections are first shown to be of the Gauss-Bonnet form. It is then noted that, by the very nature of the slope expansion, the field-redefinition theorem applies. Consequently, only the curvature-squared term is determined, while squares of its contractions are explicitly seen not to contribute. This latter property has a generalization to all orders which implies that the effective gravitational action is unavoidably ghost-free. The properties of solutions to these corrected theories are then examined. First neglecting dilatons, we find the explicit 'Schwarzschild' metrics. Both asymptotically flat and de Sitter solutions are present. The latter are however shown to be unstable. The former have horizons and singularities which are respectively smaller and less violent than in Einstein gravity; the correct sign of the slope parameter also ensures absence of naked singularities. When dilatons are included, the cosmological vacua are gratifyingly excluded. (orig.)

  17. Protein cysteine oxidation in redox signaling

    DEFF Research Database (Denmark)

    Forman, Henry Jay; Davies, Michael J; Krämer, Anna C

    2017-01-01

    Oxidation of critical signaling protein cysteines regulated by H2O2 has been considered to involve sulfenic acid (RSOH) formation. RSOH may subsequently form either a sulfenyl amide (RSNHR') with a neighboring amide, or a mixed disulfide (RSSR') with another protein cysteine or glutathione. Previ...

  18. Critical non-Abelian vortex in four dimensions and little string theory

    Science.gov (United States)

    Shifman, M.; Yung, A.

    2017-08-01

    As was shown recently, non-Abelian vortex strings supported in four-dimensional N =2 supersymmetric QCD with the U(2) gauge group and Nf=4 quark multiplets (flavors) become critical superstrings. In addition to the translational moduli, non-Abelian strings under consideration carry six orientational and size moduli. Together, they form a ten-dimensional target space required for a superstring to be critical. The target space of the string sigma model is a product of the flat four-dimensional space and a Calabi-Yau noncompact threefold, namely, the conifold. We study closed string states which emerge in four dimensions and identify them with hadrons of four-dimensional N =2 QCD. One massless state was found previously; it emerges as a massless hypermultiplet associated with the deformation of the complex structure of the conifold. In this paper, we find a number of massive states. To this end, we exploit the approach used in LST little string theory, namely, the equivalence between the critical string on the conifold and noncritical c =1 string with the Liouville field and a compact scalar at the self-dual radius. The states we find carry "baryonic" charge (its definition differs from standard). We interpret them as "monopole necklaces" formed (at strong coupling) by the closed string with confined monopoles attached.

  19. Divergent unprotected peptide macrocyclisation by palladium-mediated cysteine arylation.

    Science.gov (United States)

    Rojas, Anthony J; Zhang, Chi; Vinogradova, Ekaterina V; Buchwald, Nathan H; Reilly, John; Pentelute, Bradley L; Buchwald, Stephen L

    2017-06-01

    Macrocyclic peptides are important therapeutic candidates due to their improved physicochemical properties in comparison to their linear counterparts. Here we detail a method for a divergent macrocyclisation of unprotected peptides by crosslinking two cysteine residues with bis-palladium organometallic reagents. These synthetic intermediates are prepared in a single step from commercially available aryl bis-halides. Two bioactive linear peptides with cysteine residues at i , i + 4 and i , i + 7 positions, respectively, were cyclised to introduce a diverse array of aryl and bi-aryl linkers. These two series of macrocyclic peptides displayed similar linker-dependent lipophilicity, phospholipid affinity, and unique volume of distributions. Additionally, one of the bioactive peptides showed target binding affinity that was predominantly affected by the length of the linker. Collectively, this divergent strategy allowed rapid and convenient access to various aryl linkers, enabling the systematic evaluation of the effect of appending unit on the medicinal properties of macrocyclic peptides.

  20. Critical string from non-Abelian vortex in four dimensions

    Directory of Open Access Journals (Sweden)

    M. Shifman

    2015-11-01

    Full Text Available In a class of non-Abelian solitonic vortex strings supported in certain N=2 super-Yang–Mills theories we search for the vortex which can behave as a critical fundamental string. We use the Polchinski–Strominger criterion of the ultraviolet completeness. We identify an appropriate four-dimensional bulk theory: it has the U(2 gauge group, the Fayet–Iliopoulos term and four flavor hypermultiplets. It supports semilocal vortices with the world-sheet theory for orientational (size moduli described by the weighted CP(2,2 model. The latter is superconformal. Its target space is six-dimensional. The overall Virasoro central charge is critical. We show that the world-sheet theory on the vortex supported in this bulk model is the bona fide critical string.

  1. Ambitwistor strings and the scattering equations at one loop

    Energy Technology Data Exchange (ETDEWEB)

    Adamo, Tim; Casali, Eduardo; Skinner, David [Department of Applied Mathematics & Theoretical Physics, University of Cambridge, Wilberforce Road, Cambridge CB3 0WA (United Kingdom)

    2014-04-15

    Ambitwistor strings are chiral, infinite tension analogues of conventional string theory whose target space is the space of complex null geodesics and whose spectrum consists exclusively of massless states. At genus zero, these strings underpin the Cachazo-He-Yuan formulæ for tree level scattering of gravitons, gluons and scalars. In this paper we extend these formulæ in a number of directions. Firstly, we consider Ramond sector vertex operators and construct simple amplitudes involving space-time fermions. These agree with tree amplitudes in ten dimensional supergravity and super Yang-Mills. We then show that, after the usual GSO projections, the ambitwistor string partition function is modular invariant. We consider the scattering equations at genus one, and calculate one loop scattering amplitudes for NS-NS external states in the Type II ambitwistor string. We conjecture that these give new representations of (the integrand of) one loop supergravity amplitudes and we show that they have the expected behaviour under factorization of the worldsheet in both non-separating and separating degenerations.

  2. Functional integral approach to string theories

    International Nuclear Information System (INIS)

    Sakita, B.

    1987-01-01

    Fermionic string theory can be made supersymmetric: the superstring. It contains among others mass zero gauge fields of spin 1 and 2. The recent revival of interests in string field theories is due to the recognition of the compactified superstring theory as a viable theory of grandunification of all interactions, especially after Green and Schwarz's discovery of the gauge and gravitational anomaly cancellation in 0(32) superstring theory. New developments include string phenomenology, general discussions of compactification, new models, especially the heterotic string. These are either applications or extensions of string field theories. Although these are very exciting developments, the author limits his attention to the basics of the bosonic string theory

  3. String Theory for Pedestrians (1/3)

    CERN Multimedia

    CERN. Geneva

    2009-01-01

    This is a non-technical rapid course on string theory. Lecture 1 is an introduction to the basics of the subject: classical and quantum strings, D(irichlet) branes and string-string dualities. In lecture 2 I will discuss string unification of the fundamental forces, covering both its successes and failures. Finally in lecture 3 I will review string models of black hole microstates, the holographic gauge/gravity duality and, if time permits, potential applications to the physics of the strong interactions.

  4. String Theory for Pedestrians (2/3)

    CERN Multimedia

    CERN. Geneva

    2009-01-01

    This is a non-technical rapid course on string theory. Lecture 1 is an introduction to the basics of the subject: classical and quantum strings, D(irichlet) branes and string-string dualities. In lecture 2 I will discuss string unification of the fundamental forces, covering both its successes and failures. Finally in lecture 3 I will review string models of black hole microstates, the holographic gauge/gravity duality and, if time permits, potential applications to the physics of the strong interactions.

  5. String Theory for Pedestrians (3/3)

    CERN Multimedia

    CERN. Geneva

    2009-01-01

    This is a non-technical rapid course on string theory. Lecture 1 is an introduction to the basics of the subject: classical and quantum strings, D(irichlet) branes and string-string dualities. In lecture 2 I will discuss string unification of the fundamental forces, covering both its successes and failures. Finally in lecture 3 I will review string models of black hole microstates, the holographic gauge/gravity duality and, if time permits, potential applications to the physics of the strong interactions.

  6. Development of a cysteine-deprived and C-terminally truncated GLP-1 receptor

    DEFF Research Database (Denmark)

    Underwood, Christina Rye; Knudsen, Lotte Bjerre; Garibay, Patrick W.

    2013-01-01

    The glucagon-like peptide-1 receptor (GLP-1R) belongs to family B of the G-protein coupled receptors (GPCRs), and has become a promising target for the treatment of type 2 diabetes. Here we describe the development and characterization of a fully functional cysteine-deprived and C......-terminally truncated GLP-1R. Single cysteines were initially substituted with alanine, and functionally redundant cysteines were subsequently changed simultaneously. Our results indicate that Cys174, Cys226, Cys296 and Cys403 are important for the GLP-1-mediated response, whereas Cys236, Cys329, Cys341, Cys347, Cys438...... that the membrane proximal part of the C-terminal is involved in receptor expression at the cell surface. The results show that seven cysteines and more than half of the C-terminal tail can be removed from GLP-1R without compromising GLP-1 binding or function....

  7. Identification of novel malarial cysteine protease inhibitors using structure-based virtual screening of a focused cysteine protease inhibitor library.

    Science.gov (United States)

    Shah, Falgun; Mukherjee, Prasenjit; Gut, Jiri; Legac, Jennifer; Rosenthal, Philip J; Tekwani, Babu L; Avery, Mitchell A

    2011-04-25

    Malaria, in particular that caused by Plasmodium falciparum , is prevalent across the tropics, and its medicinal control is limited by widespread drug resistance. Cysteine proteases of P. falciparum , falcipain-2 (FP-2) and falcipain-3 (FP-3), are major hemoglobinases, validated as potential antimalarial drug targets. Structure-based virtual screening of a focused cysteine protease inhibitor library built with soft rather than hard electrophiles was performed against an X-ray crystal structure of FP-2 using the Glide docking program. An enrichment study was performed to select a suitable scoring function and to retrieve potential candidates against FP-2 from a large chemical database. Biological evaluation of 50 selected compounds identified 21 diverse nonpeptidic inhibitors of FP-2 with a hit rate of 42%. Atomic Fukui indices were used to predict the most electrophilic center and its electrophilicity in the identified hits. Comparison of predicted electrophilicity of electrophiles in identified hits with those in known irreversible inhibitors suggested the soft-nature of electrophiles in the selected target compounds. The present study highlights the importance of focused libraries and enrichment studies in structure-based virtual screening. In addition, few compounds were screened against homologous human cysteine proteases for selectivity analysis. Further evaluation of structure-activity relationships around these nonpeptidic scaffolds could help in the development of selective leads for antimalarial chemotherapy.

  8. String Theory in a Nutshell

    International Nuclear Information System (INIS)

    Skenderis, Kostas

    2007-01-01

    The book 'String Theory in a Nutshell' by Elias Kiritsis provides a comprehensive introduction to modern string theory. String theory is the leading candidate for a theory that successfully unifies all fundamental forces of nature, including gravity. The subject has been continuously developing since the early 1970s, with classic textbooks on the subject being those of Green, Schwarz and Witten (1987) and Polchinski (1998). Since the latter was published there have been substantial developments, in particular in understanding black holes and gravity/gauge theory dualities. A textbook treatment of this important material is clearly needed, both by students and researchers in string theory and by mathematicians and physicists working in related fields. This book has a good selection of material, starting from basics and moving into classic and modern topics. In particular, Kiritsis' presentation of the basic material is complementary to that of the earlier textbooks and he includes a number of topics which are not easily found or covered adequately elsewhere, for example, loop corrections to string effective couplings. Overall the book nicely covers the major advances of the last ten years, including (non-perturbative) string dualities, black hole physics, AdS/CFT and matrix models. It provides a concise but fairly complete introduction to these subjects which can be used both by students and by researchers. Moreover the emphasis is on results that are reasonably established, as is appropriate for a textbook; concise summaries are given for subjects which are still in flux, with references to relevant reviews and papers. A positive feature of the book is that the bibliography sections at the end of each chapter provide a comprehensive guide to the literature. The bibliographies point to reviews and pedagogical papers on subjects covered in this book as well as those that were omitted. It is rare for a textbook to contain such a self-contained and detailed guide to

  9. String Resonances at Hadron Colliders

    CERN Document Server

    Anchordoqui, Luis A; Dai, De-Chang; Feng, Wan-Zhe; Goldberg, Haim; Huang, Xing; Lust, Dieter; Stojkovic, Dejan; Taylor, Tomasz R

    2014-01-01

    [Abridged] We consider extensions of the standard model based on open strings ending on D-branes. Assuming that the fundamental string mass scale M_s is in the TeV range and that the theory is weakly coupled, we discuss possible signals of string physics at the upcoming HL-LHC run (3000 fb^{-1}) with \\sqrt{s} = 14 TeV, and at potential future pp colliders, HE-LHC and VLHC, operating at \\sqrt{s} = 33 and 100 TeV, respectively. In such D-brane constructions, the dominant contributions to full-fledged string amplitudes for all the common QCD parton subprocesses leading to dijets and \\gamma + jet are completely independent of the details of compactification, and can be evaluated in a parameter-free manner. We make use of these amplitudes evaluated near the first (n=1) and second (n=2) resonant poles to determine the discovery potential for Regge excitations of the quark, the gluon, and the color singlet living on the QCD stack. We show that for string scales as large as 7.1 TeV (6.1 TeV), lowest massive Regge exc...

  10. Differential geometry in string models

    International Nuclear Information System (INIS)

    Alvarez, O.

    1986-01-01

    In this article the author reviews the differential geometric approach to the quantization of strings. A seminal paper demonstrates the connection between the trace anomaly and the critical dimension. The role played by the Faddeev-Popov ghosts has been instrumental in much of the subsequent work on the quantization of strings. This paper discusses the differential geometry of two dimensional surfaces and its importance in the quantization of strings. The path integral quantization approach to strings will be carefully analyzed to determine the correct effective measure for string theories. The choice of measure for the path integral is determined by differential geometric considerations. Once the measure is determined, the manifest diffeomorphism invariance of the theory will have to be broken by using the Faddeev-Popov ansatz. The gauge fixed theory is studied in detail with emphasis on the role of conformal and gravitational anomalies. In the analysis, the path integral formulation of the gauge fixed theory requires summing over all the distinct complex structures on the manifold

  11. String theory or field theory?

    International Nuclear Information System (INIS)

    Marshakov, Andrei V

    2002-01-01

    The status of string theory is reviewed, and major recent developments - especially those in going beyond perturbation theory in the string theory and quantum field theory frameworks - are analyzed. This analysis helps better understand the role and place of string theory in the modern picture of the physical world. Even though quantum field theory describes a wide range of experimental phenomena, it is emphasized that there are some insurmountable problems inherent in it - notably the impossibility to formulate the quantum theory of gravity on its basis - which prevent it from being a fundamental physical theory of the world of microscopic distances. It is this task, the creation of such a theory, which string theory, currently far from completion, is expected to solve. In spite of its somewhat vague current form, string theory has already led to a number of serious results and greatly contributed to progress in the understanding of quantum field theory. It is these developments which are our concern in this review. (reviews of topical problems)

  12. Topological strings from quantum mechanics

    International Nuclear Information System (INIS)

    Grassi, Alba; Marino, Marcos; Hatsuda, Yasuyuki

    2014-12-01

    We propose a general correspondence which associates a non-perturbative quantum-mechanical operator to a toric Calabi-Yau manifold, and we conjecture an explicit formula for its spectral determinant in terms of an M-theoretic version of the topological string free energy. As a consequence, we derive an exact quantization condition for the operator spectrum, in terms of the vanishing of a generalized θ function. The perturbative part of this quantization condition is given by the Nekrasov-Shatashvili limit of the refined topological string, but there are non-perturbative corrections determined by the conventional topological string. We analyze in detail the cases of local P 2 , local P 1 x P 1 and local F 1 . In all these cases, the predictions for the spectrum agree with the existing numerical results. We also show explicitly that our conjectured spectral determinant leads to the correct spectral traces of the corresponding operators, which are closely related to topological string theory at orbifold points. Physically, our results provide a Fermi gas picture of topological strings on toric Calabi-Yau manifolds, which is fully non-perturbative and background independent. They also suggest the existence of an underlying theory of M2 branes behind this formulation. Mathematically, our results lead to precise, surprising conjectures relating the spectral theory of functional difference operators to enumerative geometry.

  13. Functional analysis of C1 family cysteine peptidases in the larval gut of Tenebrio molitor and Tribolium castaneum

    Science.gov (United States)

    We studied protein digestion the tenebrionids Tenebrio molitor and Tribolium castaneum, pests of stored grains and grain products, to identify potential targets for biopesticide development. Tenebrionid larvae have highly compartmentalized guts, with primarily cysteine peptidases in the acidic anter...

  14. An exact bosonization rule for c = 1 noncritical string theory

    International Nuclear Information System (INIS)

    Ishibashi, Nobuyuki; Yamaguchi, Atsushi

    2007-01-01

    We construct a string field theory for c = 1 noncritical strings using the loop variables as the string field. We show how one can express the nonrelativistic free fermions which describes the theory, in terms of these string fields

  15. Evidence for cysteine sulfinate as a neurotransmitter

    International Nuclear Information System (INIS)

    Recasens, M.; Varga, V.; Nanopoulos, D.; Saadoun, F.; Vincendon, G.; Benavides, J.

    1982-01-01

    The Na + -independent binding of L-[ 3 H]cysteine sulfinate and L-[ 3 H]cysteine sulfinate uptake were investigated in rat brain membranes and vesicles. Specific binding of L-[ 3 H]cysteine sulfinate was saturable and occurred by a single high affinity process with a Ksub(b) of 100 nM +- 9 and a capacity (Bsub(max)) of 2.4 +- 0.22 pmol/mg protein. The regional distribution of the binding of L-[ 3 H]cysteine sulfinate in the brain was found to be heterogeneous. The rate of L-[ 3 H]cysteine sulfinate uptake shows a biphasic dependence on the concentration of L-cysteine sulfinate, corresponding to a high affinity (27.2 μM) and a low affinity (398 μM) transport system. The maximum L-[ 3 H]cysteine sulfinate uptake is reached at 2min and the uptake increases as a function of the sodium concentration. Chloride and potassium ions stimulate the uptake. (Auth.)

  16. Cosmic strings and black holes

    International Nuclear Information System (INIS)

    Aryal, M.; Ford, L.H.; Vilenkin, A.

    1986-01-01

    The metric for a Schwarzschild black hole with a cosmic string passing through it is discussed. The thermodynamics of such an object is considered, and it is shown that S = (1/4)A, where S is the entropy and A is the horizon area. It is noted that the Schwarzschild mass parameter M, which is the gravitational mass of the system, is no longer identical to its energy. A solution representing a pair of black holes held apart by strings is discussed. It is nearly identical to a static, axially symmetric solution given long ago by Bach and Weyl. It is shown how these solutions, which were formerly a mathematical curiosity, may be given a more physical interpretation in terms of cosmic strings

  17. Cooperative strings and glassy interfaces.

    Science.gov (United States)

    Salez, Thomas; Salez, Justin; Dalnoki-Veress, Kari; Raphaël, Elie; Forrest, James A

    2015-07-07

    We introduce a minimal theory of glass formation based on the ideas of molecular crowding and resultant string-like cooperative rearrangement, and address the effects of free interfaces. In the bulk case, we obtain a scaling expression for the number of particles taking part in cooperative strings, and we recover the Adam-Gibbs description of glassy dynamics. Then, by including thermal dilatation, the Vogel-Fulcher-Tammann relation is derived. Moreover, the random and string-like characters of the cooperative rearrangement allow us to predict a temperature-dependent expression for the cooperative length ξ of bulk relaxation. Finally, we explore the influence of sample boundaries when the system size becomes comparable to ξ. The theory is in agreement with measurements of the glass-transition temperature of thin polymer films, and allows quantification of the temperature-dependent thickness hm of the interfacial mobile layer.

  18. Vector superconductivity in cosmic strings

    International Nuclear Information System (INIS)

    Dvali, G.R.; Mahajan, S.M.

    1992-03-01

    We argue that in most realistic cases, the usual Witten-type bosonic superconductivity of the cosmic string is automatically (independent of the existence of superconducting currents) accompanied by the condensation of charged gauge vector bosons in the core giving rise to a new vector type superconductivity. The value of the charged vector condensate is related with the charged scalar expectation value, and vanishes only if the latter goes to zero. The mechanism for the proposed vector superconductivity, differing fundamentally from those in the literature, is delineated using the simplest realistic example of the two Higgs doublet standard model interacting with the extra cosmic string. It is shown that for a wide range of parameters, for which the string becomes scalarly superconducting, W boson condensates (the sources of vector superconductivity) are necessarily excited. (author). 14 refs

  19. QCD string in the baryon

    International Nuclear Information System (INIS)

    Kalashnikova, Yu.S.; Nefediev, A.V.

    1997-01-01

    The QCD-motivated constituent string model is extended to consider the baryon. The system of three quarks propagating in the confining background field is studied in the Wilson loop approach, and the effective action is obtained. The resulting Lagrangian at large interquark distances corresponds to the Mercedes Benz string configuration. Assuming the quarks to be heavy enough to allow the adiabatic separation of quark and string junction motion and using the hyperspherical expansion for the quark subsystem we write out and solve the classical equation of motion for the junction. We quantize the motion of the junction and demonstrate that the account of these modes leads to the effective swelling of baryon in comparison with standard potential picture. The effects of finite gluonic correlation length which do not affect the excited states but appear to be substantial for the baryonic ground state, reducing the swelling considerably is discussed

  20. Noncompact symmetries in string theory

    International Nuclear Information System (INIS)

    Maharana, J.; Schwarz, J.H.

    1993-01-01

    Noncompact groups, similar to those that appeared in various supergravity theories in the 1970's have been turning up in recent studies of string theory. First it was discovered that moduli spaces of toroidal compactification are given by noncompact groups modded out by their maximal compact subgroups and discrete duality groups. Then it was found that many other moduli spaces have analogous descriptions. More recently, noncompact group symmetries have turned up in effective actions used to study string cosmology and other classical configurations. This paper explores these noncompact groups in the case of toroidal compactification both from the viewpoint of low-energy effective field theory, using the method of dimensional reduction, and from the viewpoint of the string theory world-sheet. The conclusion is that all these symmetries are intimately related. In particular, we find that Chern-Simons terms in the three-form field strength H μνρ play a crucial role. (orig.)

  1. Introduction to strings and superstrings

    International Nuclear Information System (INIS)

    Rausch de Traubenberg, M.

    1988-01-01

    The string theory is applied in the construction of a theory which allows the coupling of the four fundamental interactions and matter. The original model of the string theory describes the hadronic phenomenon of duality. The model extension, which describes the closed strings and those with a spin, is studied. The supersymmetry and the supersymmetric partner concepts are considered, in order to obtain a superstrings theory. The supersymmetry allows the formulation of a ''supertheory'', including matter, fields and gravitation. In order to explain the mass of the observable particles, the mechanism of symmetry breaking must be taken into account. The scalar state concept, originated from the supersymmetry breaking, is analyzed. This ''supertheory'' is not entirely accepted by the scientific world [fr

  2. STRING v9.1

    DEFF Research Database (Denmark)

    Franceschini, A.; Simonovic, M.; Roth, A.

    2013-01-01

    for certain model organisms and functional systems. Currently, protein interactions and associations are annotated at various levels of detail in online resources, ranging from raw data repositories to highly formalized pathway databases. For many applications, a global view of all the available interaction...... data is desirable, including lower-quality data and/or computational predictions. The STRING database (http://string-db.org/) aims to provide such a global perspective for as many organisms as feasible. Known and predicted associations are scored and integrated, resulting in comprehensive protein...... networks covering >1100 organisms. Here, we describe the update to version 9.1 of STRING, introducing several improvements: (i) we extend the automated mining of scientific texts for interaction information, to now also include full-text articles; (ii) we entirely re-designed the algorithm for transferring...

  3. The NMSSM and string theory

    International Nuclear Information System (INIS)

    Lebedev, Oleg; Ramos-Sanchez, Saul

    2009-12-01

    We study the possibility of constructing the NMSSM from the heterotic string. String derived NMSSMs are much more rare than MSSMs due to the extra requirement that there exist a light singlet which couples to the Higgs pairs. They share the common feature that the singlet self-interactions are typically suppressed, leading to either the ''decoupling'' or to the Peccei-Quinn limit of the NMSSM. In the latter case, the spectrum contains a light pseudoscalar which may be relevant to the MSSM fine-tuning problem.We provide a Z 6 heterotic orbifold example of the NMSSM with approximate Peccei-Quinn symmetry, whose origin lies in the string selection rules combined with our choice of the vacuum configuration. (orig.)

  4. On the string equation at c=1

    International Nuclear Information System (INIS)

    Nakatsu, Toshio.

    1994-07-01

    The analogue of the string equation which specifies the partition function of c=1 string with a compactification radius β is an element of Z ≥1 is described in the framework of Toda lattice hierarchy. (author)

  5. Metastable cosmic strings in realistic models

    International Nuclear Information System (INIS)

    Holman, R.

    1992-01-01

    The stability of the electroweak Z-string is investigated at high temperatures. The results show that, while finite temperature corrections can improve the stability of the Z-string, their effect is not strong enough to stabilize the Z-string in the standard electroweak model. Consequently, the Z-string will be unstable even under the conditions present during the electroweak phase transition. Phenomenologically viable models based on the gauge group SU(2) L x SU(2) R x U(1) B-L are then considered, and it is shown that metastable strings exist and are stable to small perturbations for a large region of the parameter space for these models. It is also shown that these strings are superconducting with bosonic charge carriers. The string superconductivity may be able to stabilize segments and loops against dynamical contraction. Possible implications of these strings for cosmology are discussed

  6. Covariant amplitudes in Polyakov string theory

    International Nuclear Information System (INIS)

    Aoyama, H.; Dhar, A.; Namazie, M.A.

    1986-01-01

    A manifestly Lorentz-covariant and reparametrization-invariant procedure for computing string amplitudes using Polyakov's formulation is described. Both bosonic and superstring theories are dealt with. The computation of string amplitudes is greatly facilitated by this formalism. (orig.)

  7. Cosmic string induced peculiar velocities

    International Nuclear Information System (INIS)

    van Dalen, A.; Schramm, D.N.

    1987-02-01

    We calculate analytically the probability distribution for peculiar velocities on scales from 10h -1 to 60h -1 Mpc with cosmic string loops as the dominant source of primordial gravitational perturbations. We consider a range of parameters βGμ appropriate for both hot (HDM) and cold (CDM) dark matter scenarios. An Ω = 1 CDM Universe is assumed with the loops randomly placed on a smooth background. It is shown how the effects can be estimated of loops breaking up and being born with a spectrum of sizes. It is found that to obtain large scale streaming velocities of at least 400 km/s it is necessary that either a large value for βGμ or the effect of loop fissioning and production details be considerable. Specifically, for optimal CDM string parameters Gμ = 10 -6 , β = 9, h = .5, and scales of 60h -1 Mpc, the parent size spectrum must be 36 times larger than the evolved daughter spectrum to achieve peculiar velocities of at least 400 km/s with a probability of 63%. With this scenario the microwave background dipole will be less than 800 km/s with only a 10% probability. The string induced velocity spectrum is relatively flat out to scales of about 2t/sub eq//a/sub eq/ and then drops off rather quickly. The flatness is a signature of string models of galaxy formation. With HDM a larger value of βGμ is necessary for galaxy formation since accretion on small scales starts later. Hence, with HDM, the peculiar velocity spectrum will be larger on large scales and the flat region will extend to larger scales. If large scale peculiar velocities greater than 400 km/s are real then it is concluded that strings plus CDM have difficulties. The advantages of strings plus HDM in this regard will be explored in greater detail in a later paper. 27 refs., 4 figs., 1 tab

  8. Topics in string theory

    Science.gov (United States)

    Jejjala, Vishnumohan

    2002-01-01

    This Thesis explores aspects of superstring theory on orbifold spaces and applies some of the intuition gleaned from the study of the non-commutative geometry of space-time to understanding the fractional quantum Hall effect. The moduli space of vacua of marginal and relevant deformations of N = 4 super-Yang-Mills gauge theory in four dimensions is interpreted in terms of non-commutative geometry. A formalism for thinking about the algebraic geometry of the moduli space is developed. Within this framework, the representation theory of the algebras studied provides a natural exposition of D-brane fractionation. The non-commutative moduli space of deformations preserving N = 1 supersymmetry is examined in detail through various examples. In string theory, by the AdS/CFT correspondence, deformations of the N = 4 field theory are dual to the near-horizon geometries of D-branes on orbifolds of AdS5 x S 5. The physics of D-branes on the dual AdS backgrounds is explored. Quivers encapsulate the matter content of supersymmetric field theories on the worldvolumes of D-branes at orbifold singularities. New techniques for constructing quivers are presented here. When N is a normal subgroup of a finite group G, the quiver corresponding to fixed points of the orbifold M/G is computed from a G/N action on the quiver corresponding to M/G . These techniques prove useful for constructing non-Abelian quivers and for examining discrete torsion orbifolds. Quivers obtained through our constructions contain interesting low-energy phenomenology. The matter content on a brane at an isolated singularity of the Delta27 orbifold embeds the Standard Model. The symmetries of the quiver require exactly three generations of fields in the particle spectrum. Lepton masses are suppressed relative to quark masses because lepton Yukawa couplings do not appear in the superpotential. Lepton masses are generated through the Kahler potential and are related to the supersymmetry breaking scale. The model

  9. Warped models in string theory

    International Nuclear Information System (INIS)

    Acharya, B.S.; Benini, F.; Valandro, R.

    2006-12-01

    Warped models, originating with the ideas of Randall and Sundrum, provide a fascinating extension of the standard model with interesting consequences for the LHC. We investigate in detail how string theory realises such models, with emphasis on fermion localisation and the computation of Yukawa couplings. We find, in contrast to the 5d models, that fermions can be localised anywhere in the extra dimension, and that there are new mechanisms to generate exponential hierarchies amongst the Yukawa couplings. We also suggest a way to distinguish these string theory models with data from the LHC. (author)

  10. Heterotic strings on homogeneous spaces

    International Nuclear Information System (INIS)

    Israel, D.; Kounnas, C.; Orlando, D.; Petropoulos, P.M.

    2005-01-01

    We construct heterotic string backgrounds corresponding to families of homogeneous spaces as exact conformal field theories. They contain left cosets of compact groups by their maximal tori supported by NS-NS 2-forms and gauge field fluxes. We give the general formalism and modular-invariant partition functions, then we consider some examples such as SU(2)/U(1)∝S 2 (already described in a previous paper) and the SU(3)/U(1) 2 flag space. As an application we construct new supersymmetric string vacua with magnetic fluxes and a linear dilaton. (Abstract Copyright [2005], Wiley Periodicals, Inc.)

  11. Precise Analysis of String Expressions

    DEFF Research Database (Denmark)

    Christensen, Aske Simon; Møller, Anders; Schwartzbach, Michael Ignatieff

    2003-01-01

    We perform static analysis of Java programs to answer a simple question: which values may occur as results of string expressions? The answers are summarized for each expression by a regular language that is guaranteed to contain all possible values. We present several applications of this analysis...... are automatically produced. We present extensive benchmarks demonstrating that the analysis is efficient and produces results of useful precision......., including statically checking the syntax of dynamically generated expressions, such as SQL queries. Our analysis constructs flow graphs from class files and generates a context-free grammar with a nonterminal for each string expression. The language of this grammar is then widened into a regular language...

  12. New twistor string theories revisited

    International Nuclear Information System (INIS)

    Broedel, Johannes; Wurm, Bernhard

    2009-01-01

    A gauged version of Berkovits twistor string theory featuring the particle content of N=8 supergravity was suggested by Abou-Zeid, Hull and Mason. The equations of motion for a particular multiplet in the modified theory are examined on the level of basic twistor fields and thereby shown to imply the vanishing of the negative helicity graviton on-shell. Additionally, the restrictions emerging from the equation of motion for the new gauge field B-bar reveal the chiral nature of interactions in theories constructed in this manner. Moreover, a particular amplitude in Berkovits open string theory is shown to be in agreement with the corresponding result in Einstein gravity.

  13. Introduction to field theory of strings

    International Nuclear Information System (INIS)

    Kikkawa, K.

    1987-01-01

    The field theory of bosonic string is reviewed. First, theory is treated in a light-cone gauge. After a brief survey of the first quantized theory of free string, the second quantization is discussed. All possible interactions of strings are introduced based on a smoothness condition of work sheets swept out by strings. Perturbation theory is developed. Finally a possible way to the manifest covariant formalism is discussed

  14. Twenty-five questions for string theorists

    Energy Technology Data Exchange (ETDEWEB)

    Binetruy, Pierre; /Orsay, LPT; Kane, G.L.; /Michigan U., MCTP; Lykken, Joseph D.; /Fermilab; Nelson, Brent D.; /Pennsylvania U.

    2005-09-01

    In an effort to promote communication between the formal and phenomenological branches of the high-energy theory community, we provide a description of some important issues in supersymmetric and string phenomenology. We describe each within the context of string constructions, illustrating them with specific examples where applicable. Each topic culminates in a set of questions that we believe are amenable to direct consideration by string theorists, and whose answers we think could help connect string theory and phenomenology.

  15. Hosotani model in closed string theory

    International Nuclear Information System (INIS)

    Shiraishi, Kiyoshi.

    1988-11-01

    Hosotani mechanism in the closed string theory with current algebra symmetry is described by the (old covariant) operator method. We compare the gauge symmetry breaking mechanism in a string theory which has SU(2) symmetry with the one in an equivalent compactified closed string theory. We also investigate the difference between Hosotani mechanism and Higgs mechanism in closed string theories by calculation of a fourpoint amplitude of 'Higgs' bosons at tree level. (author)

  16. Hollow micro string based calorimeter device

    DEFF Research Database (Denmark)

    2014-01-01

    positions so as to form a free released double clamped string in-between said two longitudinally distanced positions said micro-channel string comprising a microfluidic channel having a closed cross section and extending in the longitudinal direction of the hollow string, acoustical means adapted...

  17. String field representation of the Virasoro algebra

    Energy Technology Data Exchange (ETDEWEB)

    Mertes, Nicholas [Institute of Physics AS CR,Na Slovance 2, Prague 8 (Czech Republic); Department of Physics, University of Miami,Coral Gables, FL (United States); Schnabl, Martin [Institute of Physics AS CR,Na Slovance 2, Prague 8 (Czech Republic)

    2016-12-29

    We construct a representation of the zero central charge Virasoro algebra using string fields in Witten’s open bosonic string field theory. This construction is used to explore extensions of the KBc algebra and find novel algebraic solutions of open string field theory.

  18. Transverse structure of the QCD string

    International Nuclear Information System (INIS)

    Meyer, Harvey B.

    2010-01-01

    The characterization of the transverse structure of the QCD string is discussed. We formulate a conjecture as to how the stress-energy tensor of the underlying gauge theory couples to the string degrees of freedom. A consequence of the conjecture is that the energy density and the longitudinal-stress operators measure the distribution of the transverse position of the string, to leading order in the string fluctuations, whereas the transverse-stress operator does not. We interpret recent numerical measurements of the transverse size of the confining string and show that the difference of the energy and longitudinal-stress operators is a particularly natural probe at next-to-leading order. Second, we derive the constraints imposed by open-closed string duality on the transverse structure of the string. We show that a total of three independent ''gravitational'' form factors characterize the transverse profile of the closed string, and obtain the interpretation of recent effective string theory calculations: the square radius of a closed string of length β defined from the slope of its gravitational form factor, is given by (d-1/2πσ)log(β/4r 0 ) in d space dimensions. This is to be compared with the well-known result that the width of the open string at midpoint grows as (d-1/2πσ)log(r/r 0 ). We also obtain predictions for transition form factors among closed-string states.

  19. Regularization of finite temperature string theories

    International Nuclear Information System (INIS)

    Leblanc, Y.; Knecht, M.; Wallet, J.C.

    1990-01-01

    The tachyonic divergences occurring in the free energy of various string theories at finite temperature are eliminated through the use of regularization schemes and analytic continuations. For closed strings, we obtain finite expressions which, however, develop an imaginary part above the Hagedorn temperature, whereas open string theories are still plagued with dilatonic divergences. (orig.)

  20. String loop divergences and effective lagrangians

    International Nuclear Information System (INIS)

    Fischler, W.; Klebanov, I.; Susskind, L.

    1988-01-01

    We isolate logarithmic divergences from bosonic string amplitudes on a disc. These divergences are compared with 'tadpole' divergences in the effective field theory, with a covariant cosmological term implied by the counting of string coupling constants. We find an inconsistency between the two. This might be a problem in eliminating divergences from the bosonic string. (orig.)

  1. The issue of supersymmetry breaking in strings

    International Nuclear Information System (INIS)

    Binetruy, P.

    1989-12-01

    We discuss the central role that supersymmetry plays in string models, both in spacetime and at the level of the string world-sheet. The problems associated with supersymmetry-breaking are reviewed together with some of the attempts to solve them, in the string as well as the field theory approach

  2. String duality and novel theories without gravity

    International Nuclear Information System (INIS)

    Kachru, Shamit

    1998-01-01

    We describe some of the novel 6d quantum field theories which have been discovered in studies of string duality. The role these theories (and their 4d descendants) may play in alleviating the vacuum degeneracy problem in string theory is reviewed. The DLCQ of these field theories is presented as one concrete way of formulating them, independent of string theory

  3. Symmetries and Interactions in Matrix String Theory

    NARCIS (Netherlands)

    Hacquebord, F.H.

    1999-01-01

    This PhD-thesis reviews matrix string theory and recent developments therein. The emphasis is put on symmetries, interactions and scattering processes in the matrix model. We start with an introduction to matrix string theory and a review of the orbifold model that flows out of matrix string theory

  4. Exotic configurations for gauge theory strings

    International Nuclear Information System (INIS)

    Yajnik, U.A.

    1987-01-01

    This paper discusses a class of string configurations occuring in nonabelian gauge theories, which are such that a component of the charged scalar field responsible for the string has a nonvanishing expectation value in the core of the string. A systematic procedure is given for setting up the ansatz for such configurations. (orig.)

  5. General relativity invariance and string field theory

    International Nuclear Information System (INIS)

    Aref'eva, I.Ya.; Volovich, I.V.

    1987-04-01

    The general covariance principle in the string field theory is considered. The algebraic properties of the string Lie derivative are discussed. The string vielbein and spin connection are introduced and an action invariant under general co-ordinate transformation is proposed. (author). 18 refs

  6. Test particle trajectories near cosmic strings

    Indian Academy of Sciences (India)

    Gauge strings have their energy concentrated in a very thin tube, the radius of which is of the order of the symmetry- breaking scale whereas the global strings are such that their energy extends to regions far beyond the central core. Strings have an important astrophysical consequence, namely, the double quasar problem ...

  7. Are Stopped Strings Preferred in Sad Music?

    Directory of Open Access Journals (Sweden)

    David Huron

    2017-01-01

    Full Text Available String instruments may be played either with open strings (where the string vibrates between the bridge and a hard wooden nut or with stopped strings (where the string vibrates between the bridge and a performer's finger pressed against the fingerboard. Compared with open strings, stopped strings permit the use of vibrato and exhibit a darker timbre. Inspired by research on the timbre of sad speech, we test whether there is a tendency to use stopped strings in nominally sad music. Specifically, we compare the proportion of potentially open-to-stopped strings in a sample of slow, minor-mode movements with matched major-mode movements. By way of illustration, a preliminary analysis of Samuel Barber's famous Adagio from his Opus 11 string quartet shows that the selected key (B-flat minor provides the optimum key for minimizing open string tones. However, examination of a broader controlled sample of quartet movements by Haydn, Mozart and Beethoven failed to exhibit the conjectured relationship. Instead, major-mode movements were found to avoid possible open strings more than slow minor-mode movements.

  8. Introduction to the theory of strings

    International Nuclear Information System (INIS)

    Peskin, M.E.

    1985-10-01

    These lectures present, from an introductory perspective, some basic aspects of the quantum theory of strings. They treat (1) the kinematics, spectrum, and scattering amplitude of the bosonic string, (2) the spectrum and supersymmetry of Green-Schwarz superstring, and (3) the identification of the underlying gauge invariances of the string theory. 43 refs

  9. Open bosonic string in background electromagnetic field

    International Nuclear Information System (INIS)

    Nesterenko, V.V.

    1987-01-01

    The classical and quantum dynamics of an open string propagating in the D-dimensional space-time in the presence of a background electromagnetic field is investigated. An important point in this consideration is the use of the generalized light-like gauge. There are considered the strings of two types; the neutral strings with charges at their ends obeying the condition q 1 +q 2 =0 and the charged strings having a net charge q 1 +q 2 ≠ 0. The consistency of theory demands that the background electric field does not exceed its critical value. The distance between the mass levels of the neutral open string decreases (1-e 2 ) times in comparison with the free string, where e is the dimensionless strength of the electric field. The magnetic field does not affect this distance. It is shown that at a classical level the squared mass of the neutral open string has a tachyonic contribution due to the motion of the string as a whole in transverse directions. The tachyonic term disappears if one considers, instead of M 2 , the string energy in a special reference frame where the projection of the total canonical momentum of the string onto the electric field vanishes. The contributions due to zero point fluctuations to the energy spectrum of the neutral string and to the Virasoro operators in the theory of charged string are found

  10. 2-Dim. gravity and string theory

    International Nuclear Information System (INIS)

    Narain, K.S.

    1991-01-01

    The role of 2-dim. gravity in string theory is discussed. In particular d=25 string theory coupled to 2-d. gravity is described and shown to give rise to the physics of the usual 26-dim. string theory (where one does not quantise 2-d. gravity. (orig.)

  11. Duality invariant class of exact string backgrounds

    CERN Document Server

    Klimcík, C

    1994-01-01

    We consider a class of $2+D$ - dimensional string backgrounds with a target space metric having a covariantly constant null Killing vector and flat `transverse' part. The corresponding sigma models are invariant under $D$ abelian isometries and are transformed by $O(D,D)$ duality into models belonging to the same class. The leading-order solutions of the conformal invariance equations (metric, antisymmetric tensor and dilaton), as well as the action of $O(D,D)$ duality transformations on them, are exact, i.e. are not modified by $\\a'$-corrections. This makes a discussion of different space-time representations of the same string solution (related by $O(D,D|Z)$ duality subgroup) rather explicit. We show that the $O(D,D)$ duality may connect curved $2+D$-dimensional backgrounds with solutions having flat metric but, in general, non-trivial antisymmetric tensor and dilaton. We discuss several particular examples including the $2+D=4$ - dimensional background that was recently interpreted in terms of a WZW model.

  12. String formation beyond leading colour

    Energy Technology Data Exchange (ETDEWEB)

    Christiansen, Jesper R. [Department of Astronomy and Theoretical Physics, Lund University,Sölvegatan 14, Lund (Sweden); Theoretical Physics, CERN,CH-1211, Geneva 23 (Switzerland); Skands, Peter Z. [Theoretical Physics, CERN,CH-1211, Geneva 23 (Switzerland); School of Physics and Astronomy, Monash University,VIC-3800 (Australia)

    2015-08-03

    We present a new model for the hadronisation of multi-parton systems, in which colour correlations beyond leading N{sub C} are allowed to influence the formation of confining potentials (strings). The multiplet structure of SU(3) is combined with a minimisation of the string potential energy, to decide between which partons strings should form, allowing also for “baryonic” configurations (e.g., two colours can combine coherently to form an anticolour). In e{sup +}e{sup −}collisions, modifications to the leading-colour picture are small, suppressed by both colour and kinematics factors. But in pp collisions, multi-parton interactions increase the number of possible subleading connections, counteracting their naive 1/N{sub C}{sup 2} suppression. Moreover, those that reduce the overall string lengths are kinematically favoured. The model, which we have implemented in the PYTHIA 8 generator, is capable of reaching agreement not only with the important 〈p{sub ⊥}〉(n{sub charged}) distribution but also with measured rates (and ratios) of kaons and hyperons, in both ee and pp collisions. Nonetheless, the shape of their p{sub ⊥} spectra remains challenging to explain.

  13. Confinement and strings in MQCD

    International Nuclear Information System (INIS)

    Hanany, A.; Strassler, M.J.; Zaffaroni, A.

    1998-01-01

    We study aspects of confinement in the M-theory fivebrane version of QCD (MQCD). We show heavy quarks are confined in hadrons (which take the form of membrane-fivebrane bound states) for N=1 and softly broken N=2 SU(N) MQCD. We explore and clarify the transition from the exotic physics of the latter to the standard physics of the former. In particular, the many strings and quark-antiquark mesons found in N=2 field theory by Douglas and Shenker are reproduced. It is seen that in the N=1 limit all but one such meson disappears while all of the strings survive. The strings of softly broken N=2, N=1, and even non-supersymmetric SU(N) MQCD have a common ratio for their tensions as a function of the amount of flux they carry. We also comment on the almost BPS properties of the Douglas-Shenker strings and discuss the brane picture for monopole confinement on N=2 QCD Higgs branches. (orig.)

  14. Monads, strings, and M theory

    NARCIS (Netherlands)

    Hofman, C.; Park, J.-S.

    1997-01-01

    The recent developmen ts in string theory suggest that the space-time coordinates should be generalized to non-comm uting matrices. P ostulating this suggestion as the fun- damen tal geometrical principle, w e form ulate a candidate for covariant second quantized RNS superstrings as a topological

  15. Topological strings and quantum curves

    NARCIS (Netherlands)

    Hollands, L.

    2009-01-01

    This thesis presents several new insights on the interface between mathematics and theoretical physics, with a central role for Riemann surfaces. First of all, the duality between Vafa-Witten theory and WZW models is embedded in string theory. Secondly, this model is generalized to a web of

  16. Probing the string winding sector

    Energy Technology Data Exchange (ETDEWEB)

    Aldazabal, Gerardo; Mayo, Martín [G. Física CAB-CNEA and CONICET, Centro Atómico Bariloche,Av. Bustillo 9500, Bariloche (Argentina); Instituto Balseiro, Centro Atómico Bariloche,Av. Bustillo 9500, Bariloche (Argentina); Nuñez, Carmen [Instituto de Astronomía y Física del Espacio (CONICET-UBA),C.C. 67 - Suc. 28, 1428 Buenos Aires (Argentina); Departamento de Física, FCEN, Universidad de Buenos Aires,C.C. 67 - Suc. 28, 1428 Buenos Aires (Argentina)

    2017-03-17

    We probe a slice of the massive winding sector of bosonic string theory from toroidal compactifications of Double Field Theory (DFT). This string subsector corresponds to states containing one left and one right moving oscillators. We perform a generalized Kaluza Klein compactification of DFT on generic 2n-dimensional toroidal constant backgrounds and show that, up to third order in fluctuations, the theory coincides with the corresponding effective theory of the bosonic string compactified on n-dimensional toroidal constant backgrounds, obtained from three-point amplitudes. The comparison between both theories is facilitated by noticing that generalized diffeomorphisms in DFT allow to fix generalized harmonic gauge conditions that help in identifying the physical degrees of freedom. These conditions manifest as conformal anomaly cancellation requirements on the string theory side. The explicit expression for the gauge invariant effective action containing the physical massless sector (gravity+antisymmetric+gauge+ scalar fields) coupled to towers of generalized Kaluza Klein massive states (corresponding to compact momentum and winding modes) is found. The action acquires a very compact form when written in terms of fields carrying O(n,n) indices, and is explicitly T-duality invariant. The global algebra associated to the generalized Kaluza Klein compactification is discussed.

  17. String theory and cosmological singularities

    Indian Academy of Sciences (India)

    recent times, string theory is providing new perspectives of such singularities which .... holes appear as stacks of a large number of D-branes wrapped in internal .... results into a well-known measure factor which makes the wave function into a.

  18. Hawking radiation in string theories

    International Nuclear Information System (INIS)

    Sakai, N.

    1986-01-01

    String theories in a uniform gravitational field are studied to examine the Hawking radiation. An upper limit is found for the strength of the possible gravitational field: the corresponding Hawking temperature cannot be larger than the Hagedorn limiting temperature divided by π

  19. The Science of String Instruments

    CERN Document Server

    Rossing, Thomas D

    2010-01-01

    Many performing musicians, as well as instrument builders, are coming to realize the importance of understanding the science of musical instruments. This book explains how string instruments produce sound. It presents basic ideas in simple language, and it also translates some more sophisticated ideas in non-technical language. It should be of interest to performers, researchers, and instrument makers alike.

  20. String theory and cosmological singularities

    Indian Academy of Sciences (India)

    Well-known examples are singularities inside black holes and initial or final singularities in expanding or contracting universes. In recent times, string theory is providing new perspectives of such singularities which may lead to an understanding of these in the standard framework of time evolution in quantum mechanics.

  1. Defect branes as Alice strings

    International Nuclear Information System (INIS)

    Okada, Takashi; Sakatani, Yuho

    2015-01-01

    There exist various defect-brane backgrounds in supergravity theories which arise as the low energy limit of string theories. These backgrounds typically have non-trivial monodromies, and if we move a charged probe around the center of a defect, its charge will be changed by the action of the monodromy. During the process, the charge conservation law seems to be violated. In this paper, to resolve this puzzle, we examine a dynamics of the charge changing process and show that the missing charge of the probe is transferred to the background. We then explicitly construct the resultant background after the charge transfer process by utilizing dualities. This background has the same monodromy as the original defect brane, but has an additional charge which does not have any localized source. In the literature, such a charge without localized source is known to appear in the presence of Alice strings. We argue that defect branes can in fact be regarded as a realization of Alice strings in string theory and examine the charge transfer process from that perspective.

  2. Parton fragmentation and string dynamics

    International Nuclear Information System (INIS)

    Andersson, B.; Gustafson, G.; Ingelman, G.; Sjoestrand, T.

    1983-01-01

    While much has been learned recently about quark and gluon interactions in the framework of perturbative Quantum Chromodynamics, the relation between calculated parton properties and observed hadron densities involves models where dynamics and jet empirical rules have to be combined. The purpose of this article is to describe a presently successful approach which is based on a cascade jet model using String dynamics. It can readily lead to Monte Carlo jet programmes of great use when analyzing data. Production processes in an iterative cascade approach, with tunneling in a constant force field, are reviewed. Expected differences between quark and gluon jets are discussed. Low transverse momentum phenomena are also reviewed with emphasis on hyperon polarization. In so far as this approach uses a fragmentation scheme based on String dynamics, it was deemed appropriate to also include under the same cover a special report on the Classical theory of relativistic Strings, seen as the classical limit of the Dual Resonance model. The Equations of motion and interaction among strings are presented. (orig.)

  3. Particles, fields, and now strings

    International Nuclear Information System (INIS)

    Weinberg, S.

    1986-01-01

    The author traces the history of the struggle between two views of the world: a world of particles or a world of fields. These positions were crystallised as quantum field theory and S-matrix theory and now by the reintroduction of string theories. (Auth.)

  4. Modified Steiner functional string action

    International Nuclear Information System (INIS)

    Baillie, C.F.; Johnston, D.A.

    1992-01-01

    It has recently been suggested by Ambartzumian et al. that the modified Steiner functional has desirable properties as an action for random surfaces and hence string world sheets. We perform a simulation of this action on a dynamically triangulated random surface to investigate this claim and find that the surfaces are in a flat phase

  5. String theory in the bathtub

    CERN Multimedia

    CERN. Geneva

    2014-01-01

    The presence of the surrounding medium makes their dynamics dramatically different from those of ordinary string-like objects propagating in empty space, leading to quite peculiar phenomena, observed in experiments and simulations. I will argue that the effective theory provides an optimal theoretical framework to understand such phenomena, and to make precise quantitative predictions about them.

  6. Topological Strings and Integrable Hierarchies

    CERN Document Server

    Aganagic, M; Klemm, A D; Marino, M; Vafa, C; Aganagic, Mina; Dijkgraaf, Robbert; Klemm, Albrecht; Marino, Marcos; Vafa, Cumrun

    2006-01-01

    We consider the topological B-model on local Calabi-Yau geometries. We show how one can solve for the amplitudes by using W-algebra symmetries which encodes the symmetries of holomorphic diffeomorphisms of the Calabi-Yau. In the highly effective fermionic/brane formulation this leads to a free fermion description of the amplitudes. Furthermore we argue that topological strings on Calabi-Yau geometries provide a unifying picture connecting non-critical (super)strings, integrable hierarchies, and various matrix models. In particular we show how the ordinary matrix model, the double scaling limit of matrix models, and Kontsevich-like matrix model are all related and arise from studying branes in specific local Calabi-Yau three-folds. We also show how A-model topological string on P^1 and local toric threefolds (and in particular the topological vertex) can be realized and solved as B-model topological string amplitudes on a Calabi-Yau manifold.

  7. LZ-Compressed String Dictionaries

    OpenAIRE

    Arz, Julian; Fischer, Johannes

    2013-01-01

    We show how to compress string dictionaries using the Lempel-Ziv (LZ78) data compression algorithm. Our approach is validated experimentally on dictionaries of up to 1.5 GB of uncompressed text. We achieve compression ratios often outperforming the existing alternatives, especially on dictionaries containing many repeated substrings. Our query times remain competitive.

  8. Defect branes as Alice strings

    Energy Technology Data Exchange (ETDEWEB)

    Okada, Takashi [Theoretical Biology Laboratory, RIKEN,Wako 351-0198 (Japan); Sakatani, Yuho [Department of Physics and Astronomy,Seoul National University, Seoul 151-747 (Korea, Republic of)

    2015-03-25

    There exist various defect-brane backgrounds in supergravity theories which arise as the low energy limit of string theories. These backgrounds typically have non-trivial monodromies, and if we move a charged probe around the center of a defect, its charge will be changed by the action of the monodromy. During the process, the charge conservation law seems to be violated. In this paper, to resolve this puzzle, we examine a dynamics of the charge changing process and show that the missing charge of the probe is transferred to the background. We then explicitly construct the resultant background after the charge transfer process by utilizing dualities. This background has the same monodromy as the original defect brane, but has an additional charge which does not have any localized source. In the literature, such a charge without localized source is known to appear in the presence of Alice strings. We argue that defect branes can in fact be regarded as a realization of Alice strings in string theory and examine the charge transfer process from that perspective.

  9. The super G-string

    International Nuclear Information System (INIS)

    Gates, V.; Kangaroo, E.; Roachcock, M.; Gall, W.C.

    1986-01-01

    The authors describe a string theory which gives all the phenomenology of symmetry breaking. It makes use of higher dimensions, higher derivatives, higher spin, higher twist, and hierarchy. It discusses the problems of renormalizability of gravity, the cosmological constant, grand unification, supersymmetry breaking, and the command cold

  10. Strings, fields and critical phenomena

    International Nuclear Information System (INIS)

    Ambjoern, J.

    1987-07-01

    The connection between field theory and critical phenomena is reviewed. Emphasis is put on the use of Monte Carlo methods in the study of non-perturbative aspects of field theory. String theory is then described as a statistical theory of random surfaces and the critical behaviour is analyzed both by analytical and numerical methods. (orig.)

  11. Interacting bosonic strings in subcritical dimensions

    International Nuclear Information System (INIS)

    Hwang, S.; Marnelius, R.

    1988-01-01

    Interaction theory for relativistic bosonic string in spacetime dimensions below the critical value 26 is formulated using BRST techniques with an extra scalar field. One-loop zero-point amplitudes for closed strings are modular invariant. For a free scalar field, vertex operators are constructed leading to, e.g., the old dual N-tachyon tree amplitudes in D < 26. The N-tachyon one-loop expressions contain closed string poles for open strings, and are modular invariant for closed strings. However, the threshold cuts are wrong in D < 25. Only for D=25 to the considered vertex operators lead to consistency. (orig.)

  12. Micro string resonators as temperature sensors

    DEFF Research Database (Denmark)

    Larsen, T.; Schmid, S.; Boisen, A.

    2013-01-01

    The resonance frequency of strings is highly sensitive to temperature. In this work we have investigated the applicability of micro string resonators as temperature sensors. The resonance frequency of strings is a function of the tensile stress which is coupled to temperature by the thermal...... to the low thermal mass of the strings. A temperature resolution of 2.5×10-4 °C has been achieved with silicon nitride strings. The theoretical limit for the temperature resolution of 8×10-8 °C has not been reached yet and requires further improvement of the sensor....

  13. Synthesis and Application of Aurophilic Poly(Cysteine and Poly(Cysteine-Containing Copolymers

    Directory of Open Access Journals (Sweden)

    David Ulkoski

    2017-10-01

    Full Text Available The redox capacity, as well as the aurophilicity of the terminal thiol side groups, in poly(Cysteine lend a unique characteristic to this poly(amino acid or polypeptide. There are two major application fields for this polymer: (i biomedical applications in drug delivery and surface modification of biomedical devices and (ii as coating for electrodes to enhance their electrochemical sensitivity. The intended application determines the synthetic route for p(Cysteine. Polymers to be used in biomedical applications are typically polymerized from the cysteine N-carboxyanhydride by a ring-opening polymerization, where the thiol group needs to be protected during the polymerization. Advances in this methodology have led to conditions under which the polymerization progresses as living polymerization, which allows for a strict control of the molecular architecture, molecular weight and polydispersity and the formation of block copolymers, which eventually could display polyphilic properties. Poly(Cysteine used as electrode coating is typically polymerized onto the electrode by cyclic voltammetry, which actually produces a continuous, pinhole-free film on the electrode via the formation of covalent bonds between the amino group of Cysteine and the carbon of the electrode. This resulting coating is chemically very different from the well-defined poly(Cysteine obtained by ring-opening polymerizations. Based on the structure of cysteine a significant degree of cross-linking within the coating deposited by cyclic voltammetry can be assumed. This manuscript provides a detailed discussion of the ring-opening polymerization of cysteine, a brief consideration of the role of glutathione, a key cysteine-containing tripeptide, and examples for the utilization of poly(Cysteine and poly(Cysteine-containing copolymers, in both, the biomedical as well as electrochemical realm.

  14. String Theory and M-Theory

    Science.gov (United States)

    Becker, Katrin; Becker, Melanie; Schwarz, John H.

    String theory is one of the most exciting and challenging areas of modern theoretical physics. This book guides the reader from the basics of string theory to recent developments. It introduces the basics of perturbative string theory, world-sheet supersymmetry, space-time supersymmetry, conformal field theory and the heterotic string, before describing modern developments, including D-branes, string dualities and M-theory. It then covers string geometry and flux compactifications, applications to cosmology and particle physics, black holes in string theory and M-theory, and the microscopic origin of black-hole entropy. It concludes with Matrix theory, the AdS/CFT duality and its generalizations. This book is ideal for graduate students and researchers in modern string theory, and will make an excellent textbook for a one-year course on string theory. It contains over 120 exercises with solutions, and over 200 homework problems with solutions available on a password protected website for lecturers at www.cambridge.org/9780521860697. Comprehensive coverage of topics from basics of string theory to recent developments Ideal textbook for a one-year course in string theory Includes over 100 exercises with solutions Contains over 200 homework problems with solutions available to lecturers on-line

  15. String theory as a Lilliputian world

    International Nuclear Information System (INIS)

    Ambjørn, J.; Makeenko, Y.

    2016-01-01

    Lattice regularizations of the bosonic string do not allow us to probe the tachyon. This has often been viewed as the reason why these theories have never managed to make any contact to standard continuum string theories when the dimension of spacetime is larger than two. We study the continuum string theory in large spacetime dimensions where simple mean field theory is reliable. By keeping carefully the cutoff we show that precisely the existence of a tachyon makes it possible to take a scaling limit which reproduces the lattice-string results. We compare this scaling limit with another scaling limit which reproduces standard continuum-string results. If the people working with lattice regularizations of string theories are akin to Gulliver they will view the standard string-world as a Lilliputian world no larger than a few lattice spacings.

  16. String theory as a Lilliputian world

    Energy Technology Data Exchange (ETDEWEB)

    Ambjørn, J., E-mail: ambjorn@nbi.dk [The Niels Bohr Institute, Copenhagen University, Blegdamsvej 17, DK-2100 Copenhagen (Denmark); IMAPP, Radboud University, Heyendaalseweg 135, 6525 AJ, Nijmegen (Netherlands); Makeenko, Y., E-mail: makeenko@nbi.dk [The Niels Bohr Institute, Copenhagen University, Blegdamsvej 17, DK-2100 Copenhagen (Denmark); Institute of Theoretical and Experimental Physics, B. Cheremushkinskaya 25, 117218 Moscow (Russian Federation)

    2016-05-10

    Lattice regularizations of the bosonic string do not allow us to probe the tachyon. This has often been viewed as the reason why these theories have never managed to make any contact to standard continuum string theories when the dimension of spacetime is larger than two. We study the continuum string theory in large spacetime dimensions where simple mean field theory is reliable. By keeping carefully the cutoff we show that precisely the existence of a tachyon makes it possible to take a scaling limit which reproduces the lattice-string results. We compare this scaling limit with another scaling limit which reproduces standard continuum-string results. If the people working with lattice regularizations of string theories are akin to Gulliver they will view the standard string-world as a Lilliputian world no larger than a few lattice spacings.

  17. String dynamics, spontaneous breaking of supersymmetry, and dual scalar field theory

    International Nuclear Information System (INIS)

    Liu Luxin

    2009-01-01

    The dynamics of a vortex string, which describes the Nambu-Goldstone modes of the spontaneous breakdown of the target space D=4, N=1 supersymmetry and internal U(1) R symmetry to the world sheet ISO(1,1) symmetry, is constructed by using the approach of nonlinear realization. The resulting action describing the low energy oscillations of the string into the covolume (super)space is found to have an invariant synthesis form of the Akulov-Volkov and Nambu-Goto actions. Its dual scalar field action is obtained by means of introducing two vectorial Lagrangian multipliers into the action of the string.

  18. Aspects of some dualities in string theory

    Science.gov (United States)

    Kim, Bom Soo

    AdS/CFT correspondence in string theory has changed landscape of the theoretical physics. Through this celebrated duality between gravity theory and field theory, one can investigate analytically strongly coupled gauge theories such as Quantum Chromodynamics (QCD) in terms of weakly coupled string theory such as supergravity theory and vice versa. In the first part of this thesis we used this duality to construct a new type of nonlocal field theory, called Puff Field Theory, in terms of D3 branes in type IIB string theory with a geometric twist. In addition to the strong-weak duality of AdS/CFT, there also exists a weak-weak duality, called Twistor String Theory. Twistor technique is successfully used to calculate the SYM scattering amplitude in an elegant fashion. Yet, the progress in the string theory side was hindered by a non-unitary conformal gravity. We extend the Twistor string theory by introducing mass terms, in the second part of the thesis. A chiral mass term is identified as a vacuum expectation value of a conformal supergravity field and is tied with the breaking of the conformal symmetry of gravity. As a prime candidate for a quantum theory of gravity, string theory revealed many promising successes such as counting the number of microstates in supersymmetric Black Holes thermodynamics and resolution of timelike and null singularities, to name a few. Yet, the fundamental string and M-theroy formulations are not yet available. Various string theories without gravity, such as Non-Commutative Open String (NCOS) and Open Membrane (OM) theories, are very nice playground to investigate the fundamental structure of string and M-theory without the complication of gravity. In the last part of the thesis, simpler Non-Relativistic String Theories are constructed and investigated. One important motivation for those theories is related to the connection between Non-Relativistic String Theories and Non-critical String Theories through the bosonization of betagamma

  19. The Cysteine Protease–Cysteine Protease Inhibitor System Explored in Soybean Nodule Development

    Directory of Open Access Journals (Sweden)

    Marian Dorcas Quain

    2013-08-01

    Full Text Available Almost all protease families have been associated with plant development, particularly senescence, which is the final developmental stage of every organ before cell death. Proteolysis remobilizes and recycles nitrogen from senescent organs that is required, for example, seed development. Senescence-associated expression of proteases has recently been characterized using large-scale gene expression analysis seeking to identify and characterize senescence-related genes. Increasing activities of proteolytic enzymes, particularly cysteine proteases, are observed during the senescence of legume nodules, in which a symbiotic relationship between the host plant and bacteria (Rhizobia facilitate the fixation of atmospheric nitrogen. It is generally considered that cysteine proteases are compartmentalized to prevent uncontrolled proteolysis in nitrogen-fixing nodules. In addition, the activities of cysteine proteases are regulated by endogenous cysteine protease inhibitors called cystatins. These small proteins form reversible complexes with cysteine proteases, leading to inactivation. However, very little is currently known about how the cysteine protease-cysteine protease inhibitor (cystatin system is regulated during nodule development. Moreover, our current understanding of the expression and functions of proteases and protease inhibitors in nodules is fragmented. To address this issue, we have summarized the current knowledge and techniques used for studying proteases and their inhibitors including the application of “omics” tools, with a particular focus on changes in the cysteine protease-cystatin system during nodule development.

  20. Reduction of Guanosyl Radical by Cysteine and Cysteine-Glycine Studied by Time-Resolved CIDNP

    NARCIS (Netherlands)

    Morozova, O.B.; Kaptein, R.; Yurkovskaya, A.V.

    2012-01-01

    As a model for chemical DNA repair, reduction of guanosyl radicals in the reaction with cysteine or the dipeptide cysteine-glycine has been studied by time-resolved chemically induced dynamic nuclear polarization (CIDNP). Radicals were generated photochemically by pulsed laser irradiation of a

  1. Crystal Structure of Mammalian Cysteine dioxygenase: A Novel Mononuclear Iron Center for Cysteine Thiol Oxidation

    Energy Technology Data Exchange (ETDEWEB)

    Simmons,C.; Liu, Q.; Huang, Q.; Hao, Q.; Begley, T.; Karplus, P.; Stipanuk, M.

    2006-01-01

    Cysteine dioxygenase is a mononuclear iron-dependent enzyme responsible for the oxidation of cysteine with molecular oxygen to form cysteinesulfinate. This reaction commits cysteine to either catabolism to sulfate and pyruvate or to the taurine biosynthetic pathway. Cysteine dioxygenase is a member of the cupin superfamily of proteins. The crystal structure of recombinant rat cysteine dioxygenase has been determined to 1.5 Angstroms resolution, and these results confirm the canonical cupin {beta}-sandwich fold and the rare cysteinyl-tyrosine intramolecular crosslink (between Cys93 and Tyr157) seen in the recently reported murine cysteine dioxygenase structure. In contrast to the catalytically inactive mononuclear Ni(II) metallocenter present in the murine structure, crystallization of a catalytically competent preparation of rat cysteine dioxygenase revealed a novel tetrahedrally coordinated mononuclear iron center involving three histidines (His86, His88, and His140) and a water molecule. Attempts to acquire a structure with bound ligand using either co-crystallization or soaks with cysteine revealed the formation of a mixed disulfide involving Cys164 near the active site, which may explain previously observed substrate inhibition. This work provides a framework for understanding the molecular mechanisms involved in thiol dioxygenation and sets the stage for exploring the chemistry of both the novel mononuclear iron center and the catalytic role of the cysteinyl-tyrosine linkage.

  2. Reconstruction of Cysteine Biosynthesis Using Engineered Cysteine-Free and Methionine-Free Enzymes

    Science.gov (United States)

    Wang, Kendrick; Fujishima, Kosuke; Abe, Nozomi; Nakahigashi, Kenji; Endy, Drew; Rothschild, Lynn J.

    2016-01-01

    Ten of the proteinogenic amino acids can be generated abiotically while the remaining thirteen require biology for their synthesis. Paradoxically, the biosynthesis pathways observed in nature require enzymes that are made with the amino acids they produce. For example, Escherichia coli produces cysteine from serine via two enzymes that contain cysteine. Here, we substituted alternate amino acids for cysteine and also methionine, which is biosynthesized from cysteine, in serine acetyl transferase (CysE) and O-acetylserine sulfhydrylase (CysM). CysE function was rescued by cysteine-and-methionine-free enzymes and CysM function was rescued by cysteine-free enzymes. Structural modeling suggests that methionine stabilizes CysM and is present in the active site of CysM. Cysteine is not conserved among CysE and CysM protein orthologs, suggesting that cysteine is not functionally important for its own synthesis. Engineering biosynthetic enzymes that lack the amino acids being synthesized provides insights into the evolution of amino acid biosynthesis and pathways for bioengineering.

  3. String-coupling constant and dilaton vacuum expectation value in string field theory

    International Nuclear Information System (INIS)

    Yoneya, Tamiaki

    1987-01-01

    In the first quantized approaches to strings, it is well known that the string-coupling constant is determined by the vacuum expectation value of the dilaton field. This property, however, has never been demonstrated within the framework of string field theory. An explicit reparametrization of the string field associated with the shifts of the dilaton vacuum expectation value and the string-coupling constant is constructed exhibiting the above property in the light-cone field theory of the closed bosonic string. (orig.)

  4. Cysteine Biosynthesis Controls Serratia marcescens Phospholipase Activity.

    Science.gov (United States)

    Anderson, Mark T; Mitchell, Lindsay A; Mobley, Harry L T

    2017-08-15

    Serratia marcescens causes health care-associated opportunistic infections that can be difficult to treat due to a high incidence of antibiotic resistance. One of the many secreted proteins of S. marcescens is the PhlA phospholipase enzyme. Genes involved in the production and secretion of PhlA were identified by screening a transposon insertion library for phospholipase-deficient mutants on phosphatidylcholine-containing medium. Mutations were identified in four genes ( cyaA , crp , fliJ , and fliP ) that are involved in the flagellum-dependent PhlA secretion pathway. An additional phospholipase-deficient isolate harbored a transposon insertion in the cysE gene encoding a predicted serine O -acetyltransferase required for cysteine biosynthesis. The cysE requirement for extracellular phospholipase activity was confirmed using a fluorogenic phospholipase substrate. Phospholipase activity was restored to the cysE mutant by the addition of exogenous l-cysteine or O -acetylserine to the culture medium and by genetic complementation. Additionally, phlA transcript levels were decreased 6-fold in bacteria lacking cysE and were restored with added cysteine, indicating a role for cysteine-dependent transcriptional regulation of S. marcescens phospholipase activity. S. marcescens cysE mutants also exhibited a defect in swarming motility that was correlated with reduced levels of flhD and fliA flagellar regulator gene transcription. Together, these findings suggest a model in which cysteine is required for the regulation of both extracellular phospholipase activity and surface motility in S. marcescens IMPORTANCE Serratia marcescens is known to secrete multiple extracellular enzymes, but PhlA is unusual in that this protein is thought to be exported by the flagellar transport apparatus. In this study, we demonstrate that both extracellular phospholipase activity and flagellar function are dependent on the cysteine biosynthesis pathway. Furthermore, a disruption of cysteine

  5. Remarks on entanglement entropy in string theory

    Science.gov (United States)

    Balasubramanian, Vijay; Parrikar, Onkar

    2018-03-01

    Entanglement entropy for spatial subregions is difficult to define in string theory because of the extended nature of strings. Here we propose a definition for bosonic open strings using the framework of string field theory. The key difference (compared to ordinary quantum field theory) is that the subregion is chosen inside a Cauchy surface in the "space of open string configurations." We first present a simple calculation of this entanglement entropy in free light-cone string field theory, ignoring subtleties related to the factorization of the Hilbert space. We reproduce the answer expected from an effective field theory point of view, namely a sum over the one-loop entanglement entropies corresponding to all the particle-excitations of the string, and further show that the full string theory regulates ultraviolet divergences in the entanglement entropy. We then revisit the question of factorization of the Hilbert space by analyzing the covariant phase-space associated with a subregion in Witten's covariant string field theory. We show that the pure gauge (i.e., BRST exact) modes in the string field become dynamical at the entanglement cut. Thus, a proper definition of the entropy must involve an extended Hilbert space, with new stringy edge modes localized at the entanglement cut.

  6. Persistent homology and string vacua

    Energy Technology Data Exchange (ETDEWEB)

    Cirafici, Michele [Center for Mathematical Analysis, Geometry and Dynamical Systems,Instituto Superior Técnico, Universidade de Lisboa,Av. Rovisco Pais, 1049-001 Lisboa (Portugal); Institut des Hautes Études Scientifiques,Le Bois-Marie, 35 route de Chartres, F-91440 Bures-sur-Yvette (France)

    2016-03-08

    We use methods from topological data analysis to study the topological features of certain distributions of string vacua. Topological data analysis is a multi-scale approach used to analyze the topological features of a dataset by identifying which homological characteristics persist over a long range of scales. We apply these techniques in several contexts. We analyze N=2 vacua by focusing on certain distributions of Calabi-Yau varieties and Landau-Ginzburg models. We then turn to flux compactifications and discuss how we can use topological data analysis to extract physical information. Finally we apply these techniques to certain phenomenologically realistic heterotic models. We discuss the possibility of characterizing string vacua using the topological properties of their distributions.

  7. Electric drill-string telemetry

    CERN Document Server

    Carcione, J M

    2003-01-01

    We design a numerical algorithm for simulation of low-frequency electric-signal transmission through a drill string. This is represented by a transmission line with varying geometrical and electromagnetic properties versus depth, depending on the characteristics of the drill-string/formation system. These properties are implicitly modeled by the series impedance and the shunt admittance of the transmission line. The differential equations are parabolic, since at low frequencies the wave field is diffusive. We use an explicit scheme for the solution of parabolic problems, based on a Chebyshev expansion of the evolution operator and the Fourier pseudospectral method to compute the spatial derivatives. The results are verified by comparison to analytical solutions obtained for the initial-value problem with a voltage source.

  8. Bound states in string nets

    Science.gov (United States)

    Schulz, Marc Daniel; Dusuel, Sébastien; Vidal, Julien

    2016-11-01

    We discuss the emergence of bound states in the low-energy spectrum of the string-net Hamiltonian in the presence of a string tension. In the ladder geometry, we show that a single bound state arises either for a finite tension or in the zero-tension limit depending on the theory considered. In the latter case, we perturbatively compute the binding energy as a function of the total quantum dimension. We also address this issue in the honeycomb lattice where the number of bound states in the topological phase depends on the total quantum dimension. Finally, the internal structure of these bound states is analyzed in the zero-tension limit.

  9. Chronology protection in string theory

    International Nuclear Information System (INIS)

    Dyson, Lisa

    2004-01-01

    Many solutions of General Relativity appear to allow the possibility of time travel. This was initially a fascinating discovery, but geometries of this type violate causality, a basic physical law which is believed to be fundamental. Although string theory is a proposed fundamental theory of quantum gravity, geometries with closed timelike curves have resurfaced as solutions to its low energy equations of motion. In this paper, we will study the class of solutions to low energy effective supergravity theories related to the BMPV black hole and the rotating wave-D1-D5-brane system. Time travel appears to be possible in these geometries. We will attempt to build the causality violating regions and propose that stringy effects prohibit their construction. The proposed chronology protection agent for these geometries mirrors a mechanism string theory employs to resolve a class of naked singularities. (author)

  10. Introduction to bosonic string theory

    Energy Technology Data Exchange (ETDEWEB)

    Nunez, Carmen [Instituto de Astronomia y Fisica del Espacio, Buenos Aires (Argentina)], e-mail: carmen@iafe.uba.ar

    2009-07-01

    This is an introductory set of five lectures on bosonic string theory. The first one deals with the classical theory of bosonic strings. The second and third lectures cover quantization. Three basic quantization methods are sketched: the old covariant formalism, the light-cone gauge quantization, where the spectrum is derived and the Polyakov path integral formalism and in particular the partition function at one loop. Finally, the last lecture covers interactions, low energy effective action, the general idea of compactification and in particular toroidal compactification. The notes are based on books by Green, Schwarz and Witten, Polchinski, Lust and Theissen and Kaku and review papers by D'Hocker and Phong and O. Alvarez. (author)

  11. On noncommutative open string theories

    International Nuclear Information System (INIS)

    Russo, J.G.; Sheikh-Jabbari, M.M.

    2000-08-01

    We investigate new compactifications of OM theory giving rise to a 3+1 dimensional open string theory with noncommutative x 0 -x 1 and x 2 -x 3 coordinates. The theory can be directly obtained by starting with a D3 brane with parallel (near critical) electric and magnetic field components, in the presence of a RR scalar field. The magnetic parameter permits to interpolate continuously between the x 0 -x 1 noncommutative open string theory and the x 2 -x 3 spatial noncommutative U(N) super Yang-Mills theory. We discuss SL(2, Z) transformations of this theory. Using the supergravity description of the large N limit, we also compute corrections to the quark-antiquark Coulomb potential arising in the NCOS theory. (author)

  12. Finding Maximal Quasiperiodicities in Strings

    DEFF Research Database (Denmark)

    Brodal, Gerth Stølting; Pedersen, Christian N. S.

    2000-01-01

    of length n in time O(n log n) and space O(n). Our algorithm uses the suffix tree as the fundamental data structure combined with efficient methods for merging and performing multiple searches in search trees. Besides finding all maximal quasiperiodic substrings, our algorithm also marks the nodes......Apostolico and Ehrenfeucht defined the notion of a maximal quasiperiodic substring and gave an algorithm that finds all maximal quasiperiodic substrings in a string of length n in time O(n log2 n). In this paper we give an algorithm that finds all maximal quasiperiodic substrings in a string...... in the suffix tree that have a superprimitive path-label....

  13. A new approach to strings and superstrings

    International Nuclear Information System (INIS)

    Sparano, G.

    1988-01-01

    The subject of this thesis is a new, more general, action principle for strings, superstrings, and extended objects in any number of dimensions. The origin and motivations for this approach can be found in the context of the study of the symmetries of string theories and, more specifically, are related to the application of K.S.K. (Kirillov, Souriau, Kostant) construction to strings. The main results we find are: (A) A classification of string theories analogous to the classification of relativistic point particles as massive, massless and tachionic with or without spin. Nambu-Goto string and Schild null string emerge as special cases of a more general classification of strings. (B) A new method to introduce spin in strings by using a Wess-Zumino term in the action. (C) Several results are obtained through the study of the configuration space which shows a rich topological structure: for the Nambu-Goto string in any number of dimensions it is found the existence of theta states analogous to the theta-vacua of nonabelian gauge theories. For the closed Schild Null string, in four dimensions, this analysis shows Z2 solitons and the possibility of quantizing the system so that the states are spinorial (have half odd integral spin) even though the Lagrangian consists only of bosonic variables. (D) Unlike Nambu-Goto string, the quantization of Schild Null string is consistent in any number of space-time dimensions. Besides these concrete results, the formalism we introduce will hopefully give also new insights in the problem of the hidden symmetries of the string

  14. Renormalization-group flows and charge transmutation in string theory

    International Nuclear Information System (INIS)

    Orlando, D.; Petropoulos, P.M.; Sfetsos, K.

    2006-01-01

    We analyze the behaviour of heterotic squashed-Wess-Zumino-Witten backgrounds under renormalization-group flow. The flows we consider are driven by perturbation creating extra gauge fluxes. We show how the conformal point acts as an attractor from both the target-space and world-sheet points of view. We also address the question of instabilities created by the presence of closed time-like curves in string backgrounds. (Abstract Copyright [2006], Wiley Periodicals, Inc.)

  15. Bosonization methods in string theory

    International Nuclear Information System (INIS)

    Abdalla, E.

    1988-02-01

    The use of bosonization/fermionization techniques to convert non-linear operators of the dual, is discussed. Non abelian bosonization to the case where the central charge of the Kac-Moody algebra is not unity, is generalized. In particular, using this generalization of non-abelian bosonization, the bosonic string vertex of the compactified theory; turns out to be fundamental field of thre fermionic theory, or bound states of it thus permiting explicit computations easily. (author) [pt

  16. Macroscopic constraints on string unification

    International Nuclear Information System (INIS)

    Taylor, T.R.

    1989-03-01

    The comparison of sting theory with experiment requires a huge extrapolation from the microscopic distances, of order of the Planck length, up to the macroscopic laboratory distances. The quantum effects give rise to large corrections to the macroscopic predictions of sting unification. I discus the model-independent constraints on the gravitational sector of string theory due to the inevitable existence of universal Fradkin-Tseytlin dilatons. 9 refs

  17. Minimal string theory is logarithmic

    International Nuclear Information System (INIS)

    Ishimoto, Yukitaka; Yamaguchi, Shun-ichi

    2005-01-01

    We study the simplest examples of minimal string theory whose worldsheet description is the unitary (p,q) minimal model coupled to two-dimensional gravity ( Liouville field theory). In the Liouville sector, we show that four-point correlation functions of 'tachyons' exhibit logarithmic singularities, and that the theory turns out to be logarithmic. The relation with Zamolodchikov's logarithmic degenerate fields is also discussed. Our result holds for generic values of (p,q)

  18. Algebras, lattices and strings 1986

    International Nuclear Information System (INIS)

    Olive, D.

    1987-01-01

    The formulation of the string theory of unified elementary particle interactions in terms of operators in a Fock space is now seen to relate to the representation theory of certain infinite dimensional algebras. This insight has enhanced the understanding of the physical and mathematical theories involved and furthermore has led to applications in other branches of theoretical physics. A brief account of the new results is given here. (orig.)

  19. LHC magnet string in 1994

    CERN Multimedia

    1994-01-01

    On 6-7 December 1994, a string of powerful superconducting magnets for CERN's next particle accelerator, the Large Hadron Collider (LHC), ran successfully at 8.36 tesla for 24 hours. This magnetic field is 100 000 times that of the Earth and is required to keep beams of protons travelling on the correct circular path over 27 km at 7 TeV in the new LHC accelerator.

  20. Braiding knots with topological strings

    International Nuclear Information System (INIS)

    Gu, Jie

    2015-08-01

    For an arbitrary knot in a three-sphere, the Ooguri-Vafa conjecture associates to it a unique stack of branes in type A topological string on the resolved conifold, and relates the colored HOMFLY invariants of the knot to the free energies on the branes. For torus knots, we use a modified version of the topological recursion developed by Eynard and Orantin to compute the free energies on the branes from the Aganagic-Vafa spectral curves of the branes, and find they are consistent with the known colored HOMFLY knot invariants a la the Ooguri-Vafa conjecture. In addition our modified topological recursion can reproduce the correct closed string free energies, which encode the information of the background geometry. We conjecture the modified topological recursion is applicable for branes associated to hyperbolic knots as well, encouraged by the observation that the modified topological recursion yields the correct planar closed string free energy from the Aganagic-Vafa spectral curves of hyperbolic knots. This has implications for the knot theory concerning distinguishing mutant knots with colored HOMFLY invariants. Furthermore, for hyperbolic knots, we present methods to compute colored HOMFLY invariants in nonsymmetric representations of U(N). The key step in this computation is computing quantum 6j-symbols in the quantum group U q (sl N ).

  1. Early reheating and cosmic strings

    International Nuclear Information System (INIS)

    Stebbins, A.J. III.

    1987-01-01

    In the first chapter, possible thermal histories of the universe during the epoch z = 10 - 100 are studied. Expression for the fractional ionization and electron temperature are given in the case of homogeneous heating as a function of the parameters of arbitrary ionizing sources. It is shown that present and future limits on spectral distortions to the microwave background radiation do not provide very restrictive constraints on possible thermal histories of the universe. Heating by cosmic rays and very massive stars is discussed. In the second chapter, accretion of matter onto the wakes left behind by horizon-size pieces of cosmic string is studied. It was found that in a universe containing cold dissipationless matter (CDM), accretion onto wakes produce a network of sheet-like regions with a nonlinear density enhancement. In the third chapter, a formalism is developed for calculating the microwave ansisotropy produced by cosmic string loops in Minkowski space. The final formalism involves doing a one-dimensional integral along the string for each point on the sky. Exact solutions have only been found for a circular loop seen face-on. The equations are integrated for one particular loop configuration at nine points in its evolution

  2. The STRING database in 2017

    DEFF Research Database (Denmark)

    Szklarczyk, Damian; Morris, John H; Cook, Helen

    2017-01-01

    A system-wide understanding of cellular function requires knowledge of all functional interactions between the expressed proteins. The STRING database aims to collect and integrate this information, by consolidating known and predicted protein-protein association data for a large number of organi......A system-wide understanding of cellular function requires knowledge of all functional interactions between the expressed proteins. The STRING database aims to collect and integrate this information, by consolidating known and predicted protein-protein association data for a large number...... of organisms. The associations in STRING include direct (physical) interactions, as well as indirect (functional) interactions, as long as both are specific and biologically meaningful. Apart from collecting and reassessing available experimental data on protein-protein interactions, and importing known...... pathways and protein complexes from curated databases, interaction predictions are derived from the following sources: (i) systematic co-expression analysis, (ii) detection of shared selective signals across genomes, (iii) automated text-mining of the scientific literature and (iv) computational transfer...

  3. Conformal symmetry and string theories

    International Nuclear Information System (INIS)

    Kumar, A.

    1987-01-01

    This thesis is devoted to the study of various aspects of the 2-dimensional conformal field theory and its applications to strings. We make a short review of the conformal field theory and its supersymmetric extension, called superconformal field theory. We present an elegant superspace formulation of these theories and solve the condition for the closure of the superconformal algebra. The we go on to classify the superconformal field theories according to these solutions. We prove that N ≥ 5 superconformal algebra, with N being the number of supersymmetries, does not have central charge. We find the primary representations of all the interesting superconformal algebra. We study the quantization of the superconformal theories and derive the constraints on the central charge of the algebra that has to be satisfied for a consistent quantum theory. This quantization process also determines the ground state energy of the system and the spectrum of the model. We study the global aspects of the conformal symmetry and its role in the construction of consistent heterotic string theories. We prove the uniqueness of heterotic superstring theories in 10 dimensions in the fermionic constructions. We show how the vertex operators are closely associated with the primary field representation of the conformal algebra. We utilize these vertex operator constructions to obtain tree amplitudes in the 10-dimensional heterotic string theory. We show by explicit calculation at the 3-point level that the scattering amplitudes derived from the heterotic superstring are same as the ones obtained from 10-dimensional supergravity theories

  4. Nuclear force from string theory

    International Nuclear Information System (INIS)

    Hashimoto, Koji; Sakai, Tadakatsu; Sugimoto, Shigeki

    2009-01-01

    We compute the nuclear force in a holographic model of QCD on the basis of a D4-D8 brane configuration in type IIA string theory. The repulsive core of nucleons is important in nuclear physics, but its origin has not been well understood in strongly coupled QCD. We find that the string theory via gauge/string duality deduces this repulsive core at a short distance between nucleons. Since baryons in the model are realized as solitons given by Yang-Mills instanton configuration on flavor D8-branes, ADHM construction of two instantons probes well the nucleon interaction at short scale, which provides the nuclear force quantitatively. We obtain a central force, as well as a tensor force, which is strongly repulsive as suggested in experiments and lattice results. In particular, the nucleon-nucleon potential V(r) (as a function of the distance) scales as r -2 , which is peculiar to the holographic model. We compare our results with the one-boson exchange model using the nucleon-nucleon-meson coupling obtained in our previous paper. (author)

  5. On the null origin of the ambitwistor string

    Energy Technology Data Exchange (ETDEWEB)

    Casali, Eduardo [Mathematical Institute, University of Oxford,Woodstock Road, Oxford, OX2 6GG (United Kingdom); Tourkine, Piotr [Department of Applied Mathematics and Theoretical Physics,Wilberforce Road, Cambridge, CB3 0WA (United Kingdom)

    2016-11-07

    In this paper we present the null string origin of the ambitwistor string. Classically, the null string is the tensionless limit of string theory, and so too is the ambitwistor string. Both have as constraint algebra the Galilean Conformal Algebra in two dimensions. But something interesting happens in the quantum theory since there is an ambiguity in quantizing the null string. We show that, given a particular choice of quantization scheme and a particular gauge, the null string coincides with the ambitwistor string both classically and quantum mechanically. We also show that the same holds for the spinning versions of the null string and ambitwistor string. With these results we clarify the relationship between the ambitwistor string, the null string, the usual string and the Hohm-Siegel-Zwiebach theory.

  6. Apparatus and method for vibrating a casing string during cementing

    International Nuclear Information System (INIS)

    Rankin, R.E.; Rankin, K.T.

    1992-01-01

    This patent describes a method of cementing a string of casing in a well. It comprises: securing a vibrating device into the string of casing near the lower end of the string of casing; lowering the string of casing into the well to the desired depth; pumping a cement slurry down the string of casing; causing a portion of the cement slurry being pumped down the string of casing to vibrate the vibrating device; and wherein the vibrating device is secured in the string of casing by cementing the vibrating device within a sub, then securing the sub into the string of casing prior to lowering the string of casing into the well

  7. String theory and quantum gravity '92

    International Nuclear Information System (INIS)

    Harvey, J.; Iengo, R.; Narain, K.S.; Randjbar Daemi, S.; Verlinde, H.

    1993-01-01

    These proceedings of the 1992 Trieste Spring School and Workshop on String Theory and Quantum Gravity contains introductions and overviews of recent work on the use of two-dimensional string inspired models in the study of black holes, a lecture on gravitational scattering at planckian energies, another on the physical properties of higher-dimensional black holes and black strings in string theory, a discussion on N=2 superconformal field theories, a lecture about the application of matrix model techniques to the study of string theory in two dimensions, and an overview of the current status and developments in string field theory. Connections with models in statistical mechanics are also discussed. These proceedings contain seven lectures and ten contributions. Refs and figs

  8. A global string with an event horizon

    International Nuclear Information System (INIS)

    Harari, D.; Polychronakos, A.P.

    1990-01-01

    An idealized infinite straight global string in flat space-time has a logarithmically divergent energy per unit length. With gravity included, the standard field theoretical model for a straight global string has been shown to give rise to a repulsive gravitational field, and to develop a curvature singularity at a finite proper distance off the string core. Here we point out that alternative (although probably unrealistic) equations of state for the core of the global string produce a non-singular cylindrically symmetric metric with an event horizon at a finite proper distance off the core, such that timelike observers beyond the horizon are bound to move away from the string. The same geometric structure applies to the standard field theoretical model for a vortex in (2+1)-dimensional gravity. Thermal effects in a quantum field theory around the string due to the presence of the horizon are also calculated. (orig.)

  9. A novel string field theory solving string theory by liberating left and right movers

    International Nuclear Information System (INIS)

    Nielsen, Holger B.; Ninomiya, Masao

    2014-01-01

    We put forward ideas to a novel string field theory based on making some “objects” that essentially describe “liberated” left- and right- mover fields X L μ (τ+σ) and X R μ (τ−σ) on the string. Our novel string field theory is completely definitely different from any other string theory in as far as a “null set” of information in the string field theory Fock space has been removed relatively, to the usual string field theories. So our theory is definitely new. The main progress is that we manage to make our novel string field theory provide the correct mass square spectrum for the string. We finally suggest how to obtain the Veneziano amplitude in our model

  10. Comment on 'Quantum string seal is insecure'

    International Nuclear Information System (INIS)

    He Guangping

    2007-01-01

    An attack strategy was recently proposed by Chau [Phys. Rev. A 75, 012327 (2007)], which was claimed to be able to break all quantum string seal protocols. Here it will be shown that the attack cannot obtain nontrivial information and escape the detection simultaneously in a class of quantum string seal, including the one proposed by He [Int. J. Quantum Inf. 4, 677 (2006)]. Thus it is insufficient to conclude that all quantum string seals are insecure

  11. Specifications for Managed Strings, Second Edition

    Science.gov (United States)

    2010-05-01

    const char * cstr , const size_t maxsize, const char *charset); 10 | CMU/SEI-2010-TR-018 Runtime-Constraints s shall not be a null pointer...strcreate_m function creates a managed string, referenced by s, given a conventional string cstr (which may be null or empty). maxsize specifies the...characters to those in the null-terminated byte string cstr (which may be empty). If charset is a null pointer, no restricted character set is defined. If

  12. Exact solutions and singularities in string theory

    International Nuclear Information System (INIS)

    Horowitz, G.T.; Tseytlin, A.A.

    1994-01-01

    We construct two new classes of exact solutions to string theory which are not of the standard plane wave of gauged WZW type. Many of these solutions have curvature singularities. The first class includes the fundamental string solution, for which the string coupling vanishes near the singularity. This suggests that the singularity may not be removed by quantum corrections. The second class consists of hybrids of plane wave and gauged WZW solutions. We discuss a four-dimensional example in detail

  13. Cosmological string theory with thermal energy

    International Nuclear Information System (INIS)

    Shiraishi, Kiyoshi.

    1988-09-01

    An attempt to construct a cosmological scenario directly from string theory is made. Cosmological string theory was presented by Antoniadis, Bachas, Ellis and Nanopoulos. They also expect loop effects on cosmological string theory. In this paper, we point out the other importance of the one-loop effect, the finite temperature effect. The equations of motion for background geometry at finite temperature is given. We address a problem on derivation of the effective action at non-zero temperature. (author)

  14. Towards an observational appraisal of string cosmology

    Energy Technology Data Exchange (ETDEWEB)

    Mulryne, David J [Astronomy Unit, School of Mathematical Sciences, Queen Mary University of London, Mile End Road, London, E1 4NS (United Kingdom); Ward, John, E-mail: d.mulryne@qmul.ac.uk, E-mail: jwa@uvic.ca [Department of Physics and Astronomy, University of Victoria, Victoria, BC, V8P 1A1 (Canada)

    2011-10-21

    We review the current observational status of string cosmology when confronted with experimental datasets. We begin by defining common observational parameters and discuss how they are determined for a given model. Then we review the observable footprints of several string theoretic models, discussing the significance of various potential signals. Throughout we comment on present and future prospects of finding evidence for string theory in cosmology and on significant issues for the future.

  15. Towards an observational appraisal of string cosmology

    International Nuclear Information System (INIS)

    Mulryne, David J; Ward, John

    2011-01-01

    We review the current observational status of string cosmology when confronted with experimental datasets. We begin by defining common observational parameters and discuss how they are determined for a given model. Then we review the observable footprints of several string theoretic models, discussing the significance of various potential signals. Throughout we comment on present and future prospects of finding evidence for string theory in cosmology and on significant issues for the future.

  16. String model of black hole microstates

    International Nuclear Information System (INIS)

    Larsen, F.

    1997-01-01

    The statistical mechanics of black holes arbitrarily far from extremality is modeled by a gas of weakly interacting strings. As an effective low-energy description of black holes the string model provides several highly nontrivial consistency checks and predictions. Speculations on a fundamental origin of the model suggest surprising simplifications in nonperturbative string theory, even in the absence of supersymmetry. copyright 1997 The American Physical Society

  17. Dilatation transformation in the string model

    Energy Technology Data Exchange (ETDEWEB)

    Chikashige, Y [Tokyo Univ. (Japan). Coll. of General Education; Hosoda, M; Saito, S

    1975-05-01

    Dilatation transformation is discussed in the string model. We show that it becomes meaningful in the infinite slope limit of Regge trajectories for the motion of a free string. It turns out to be equivalent to the high energy limit of the dual amplitudes, with the Regge slope kept finite, in the case of interacting strings. The scaling phenomenon is explained from this point of view.

  18. On effective theories of topological strings

    International Nuclear Information System (INIS)

    Elitzur, S.; Forge, A.; Rabinovici, E.

    1992-01-01

    We study the construction of effective target-space theories of topological string theories. The example of the CP1 topological sigma model is analysed in detail. An effective target-space theory whose correlation functions are defined by the sum over connected Riemann surfaces of all genera is found to be itself topological. The values of the couplings of this effective theory are expressed in terms of those of the world-sheet theory for a general CP1-like world-sheet model. Any model of this type can be obtained as an effective theory. The definition of the effective theory's expectation values as a sum over disconnected surfaces as well, is shown not to be compatible with those of a topological theory, at least as long as the connectivity of the target space is kept fixed. Dilaton-type couplings emerge in the full lagrangian realization of the moduli space of topological theories with n observables. En route, we encounter a nonperturbative duality, an equivalence of theories with different world-sheets and discuss the relation between the cosmological constant in these finite theories and the zero-point function. (orig.)

  19. Parameters optimization defined by statistical analysis for cysteine-dextran radiolabeling with technetium tricarbonyl core.

    Science.gov (United States)

    Núñez, Eutimio Gustavo Fernández; Faintuch, Bluma Linkowski; Teodoro, Rodrigo; Wiecek, Danielle Pereira; da Silva, Natanael Gomes; Papadopoulos, Minas; Pelecanou, Maria; Pirmettis, Ioannis; de Oliveira Filho, Renato Santos; Duatti, Adriano; Pasqualini, Roberto

    2011-04-01

    The objective of this study was the development of a statistical approach for radiolabeling optimization of cysteine-dextran conjugates with Tc-99m tricarbonyl core. This strategy has been applied to the labeling of 2-propylene-S-cysteine-dextran in the attempt to prepare a new class of tracers for sentinel lymph node detection, and can be extended to other radiopharmaceuticals for different targets. The statistical routine was based on three-level factorial design. Best labeling conditions were achieved. The specific activity reached was 5 MBq/μg. Crown Copyright © 2011. Published by Elsevier Ltd. All rights reserved.

  20. Parameters optimization defined by statistical analysis for cysteine-dextran radiolabeling with technetium tricarbonyl core

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez Nunez, Eutimio Gustavo, E-mail: eutimiocu@yahoo.co [Radiopharmacy Center, Institute of Energetic and Nuclear Research, Sao Paulo, SP 05508-000 (Brazil); Linkowski Faintuch, Bluma; Teodoro, Rodrigo; Pereira Wiecek, Danielle; Gomes da Silva, Natanael [Radiopharmacy Center, Institute of Energetic and Nuclear Research, Sao Paulo, SP 05508-000 (Brazil); Papadopoulos, Minas [Institute of Radioisotopes, Radiodiagnostic Products, National Center for Scientific Research ' Demokritos' , Athens (Greece); Pelecanou, Maria [Institute of Biology, National Center for Scientific Research ' Demokritos' , Athens (Greece); Pirmettis, Ioannis [Institute of Radioisotopes, Radiodiagnostic Products, National Center for Scientific Research ' Demokritos' , Athens (Greece); Santos Oliveira Filho, Renato de [Faculty of Medicine, Federal University of Sao Paulo, SP (Brazil); Duatti, Adriano [Department of Radiological Sciences, University of Ferrara, Ferrara (Italy); Pasqualini, Roberto [CIS Bio International, Gif sur Yvette (France)

    2011-04-15

    The objective of this study was the development of a statistical approach for radiolabeling optimization of cysteine-dextran conjugates with Tc-99m tricarbonyl core. This strategy has been applied to the labeling of 2-propylene-S-cysteine-dextran in the attempt to prepare a new class of tracers for sentinel lymph node detection, and can be extended to other radiopharmaceuticals for different targets. The statistical routine was based on three-level factorial design. Best labeling conditions were achieved. The specific activity reached was 5 MBq/{mu}g.

  1. Perturbative string theory in BRST invariant formalism

    International Nuclear Information System (INIS)

    Di Vecchia, P.; Hornfeck, K.; Frau, M.; Lerda, A.

    1988-01-01

    In this talk we present a constructive and very explicit way of calculating multiloop amplitudes in string theories. The main ingredients are the BRST invariant N String Vertex and the BRST invariant twisted propagator. This approach naturally leads to the Schottky parametrization of moduli space in terms of multipliers and fixed points of the g projective transformations which characterize a Riemann surface of genus g. The complete expression (including measure) of the multiloop corrections to the N String Vertex for the bosonic string is exhibited. (orig.)

  2. Cosmological horizons, quintessence and string theory

    International Nuclear Information System (INIS)

    Kaloper, Nemanja

    2003-01-01

    String theory is presently the best candidate for a quantum theory of gravity unified with other forces. It is natural to hope that applications of string theory to cosmology may shed new light on the cosmological conundra, such as singularities, initial conditions, cosmological constant problem and the origin of inflation. Before we can apply string theory to cosmology, there are important conceptual and practical problems which must be addressed. We have reviewed here some of these problems, related to how one defines string theory in a cosmological setting. (author)

  3. Minimal string theories and integrable hierarchies

    Science.gov (United States)

    Iyer, Ramakrishnan

    Well-defined, non-perturbative formulations of the physics of string theories in specific minimal or superminimal model backgrounds can be obtained by solving matrix models in the double scaling limit. They provide us with the first examples of completely solvable string theories. Despite being relatively simple compared to higher dimensional critical string theories, they furnish non-perturbative descriptions of interesting physical phenomena such as geometrical transitions between D-branes and fluxes, tachyon condensation and holography. The physics of these theories in the minimal model backgrounds is succinctly encoded in a non-linear differential equation known as the string equation, along with an associated hierarchy of integrable partial differential equations (PDEs). The bosonic string in (2,2m-1) conformal minimal model backgrounds and the type 0A string in (2,4 m) superconformal minimal model backgrounds have the Korteweg-de Vries system, while type 0B in (2,4m) backgrounds has the Zakharov-Shabat system. The integrable PDE hierarchy governs flows between backgrounds with different m. In this thesis, we explore this interesting connection between minimal string theories and integrable hierarchies further. We uncover the remarkable role that an infinite hierarchy of non-linear differential equations plays in organizing and connecting certain minimal string theories non-perturbatively. We are able to embed the type 0A and 0B (A,A) minimal string theories into this single framework. The string theories arise as special limits of a rich system of equations underpinned by an integrable system known as the dispersive water wave hierarchy. We find that there are several other string-like limits of the system, and conjecture that some of them are type IIA and IIB (A,D) minimal string backgrounds. We explain how these and several other string-like special points arise and are connected. In some cases, the framework endows the theories with a non

  4. Joining-Splitting Interaction of Noncritical String

    Science.gov (United States)

    Hadasz, Leszek; Jaskólski, Zbigniew

    The joining-splitting interaction of noncritical bosonic string is analyzed in the light-cone formulation. The Mandelstam method of constructing tree string amplitudes is extended to the bosonic massive string models of the discrete series. The general properties of the Liouville longitudinal excitations which are necessary and sufficient for the Lorentz covariance of the light-cone amplitudes are derived. The results suggest that the covariant and the light-cone approach are equivalent also in the noncritical dimensions. Some aspects of unitarity of interacting noncritical massive string theory are discussed.

  5. Gauge invariant actions for string models

    International Nuclear Information System (INIS)

    Banks, T.

    1986-06-01

    String models of unified interactions are elegant sets of Feynman rules for the scattering of gravitons, gauge bosons, and a host of massive excitations. The purpose of these lectures is to describe the progress towards a nonperturbative formulation of the theory. Such a formulation should make the geometrical meaning of string theory manifest and explain the many ''miracles'' exhibited by the string Feynman rules. There are some new results on gauge invariant observables, on the cosmological constant, and on the symmetries of interacting string field theory. 49 refs

  6. Sigma models and renormalization of string loops

    International Nuclear Information System (INIS)

    Tseytlin, A.A.

    1989-05-01

    An extension of the ''σ-model β-functions - string equations of motion'' correspondence to the string loop level is discussed. Special emphasis is made on how the renormalization group acts in string loops and, in particular, on the renormalizability property of the generating functional Z-circumflex for string amplitudes (related to the σ model partition function integrated over moduli). Renormalization of Z-circumflex at one and two loop order is analyzed in some detail. We also discuss an approach to renormalization based on operators of insertion of topological fixtures. (author). 70 refs

  7. Scaling laws for nonintercommuting cosmic string networks

    International Nuclear Information System (INIS)

    Martins, C.J.A.P.

    2004-01-01

    We study the evolution of noninteracting and entangled cosmic string networks in the context of the velocity-dependent one-scale model. Such networks may be formed in several contexts, including brane inflation. We show that the frozen network solution L∝a, although generic, is only a transient one, and that the asymptotic solution is still L∝t as in the case of ordinary (intercommuting) strings, although in the present context the universe will usually be string dominated. Thus the behavior of two strings when they cross does not seem to affect their scaling laws, but only their densities relative to the background

  8. Anti-trypanosomal activity of non-peptidic nitrile-based cysteine protease inhibitors.

    Science.gov (United States)

    Burtoloso, Antonio C B; de Albuquerque, Sérgio; Furber, Mark; Gomes, Juliana C; Gonçalez, Cristiana; Kenny, Peter W; Leitão, Andrei; Montanari, Carlos A; Quilles, José Carlos; Ribeiro, Jean F R; Rocha, Josmar R

    2017-02-01

    The cysteine protease cruzipain is considered to be a validated target for therapeutic intervention in the treatment of Chagas disease. Anti-trypanosomal activity against the CL Brener strain of T. cruzi was observed in the 0.1 μM to 1 μM range for three nitrile-based cysteine protease inhibitors based on two scaffolds known to be associated with cathepsin K inhibition. The two compounds showing the greatest potency against the trypanosome were characterized by EC50 values (0.12 μM and 0.25 μM) that were an order of magnitude lower than the corresponding Ki values measured against cruzain, a recombinant form of cruzipain, in an enzyme inhibition assay. This implies that the anti-trypanosomal activity of these two compounds may not be explained only by the inhibition of the cruzain enzyme, thereby triggering a putative polypharmacological profile towards cysteine proteases.

  9. Biological roles of cysteine proteinases in the pathogenesis of Trichomonas vaginalis

    Science.gov (United States)

    Hernández, Hilda M.; Marcet, Ricardo; Sarracent, Jorge

    2014-01-01

    Human trichomonosis, infection with Trichomonas vaginalis, is the most common non-viral sexually transmitted disease in the world. The host-parasite interaction and pathophysiological processes of trichomonosis remain incompletely understood. This review focuses on the advancements reached in the area of the pathogenesis of T. vaginalis, especially in the role of the cysteine proteinases. It highlights various approaches made in this field and lists a group of trichomonad cysteine proteinases involved in diverse processes such as invasion of the mucous layer, cytoadherence, cytotoxicity, cytoskeleton disruption of red blood cells, hemolysis, and evasion of the host immune response. A better understanding of the biological roles of cysteine proteinases in the pathogenesis of this parasite could be used in the identification of new chemotherapeutic targets. An additional advantage could be the development of a vaccine in order to reduce transmission of T. vaginalis. PMID:25348828

  10. Identification of semicarbazones, thiosemicarbazones and triazine nitriles as inhibitors of Leishmania mexicana cysteine protease CPB.

    Directory of Open Access Journals (Sweden)

    Jörg Schröder

    Full Text Available Cysteine proteases of the papain superfamily are present in nearly all eukaryotes. They play pivotal roles in the biology of parasites and inhibition of cysteine proteases is emerging as an important strategy to combat parasitic diseases such as sleeping sickness, Chagas' disease and leishmaniasis. Homology modeling of the mature Leishmania mexicana cysteine protease CPB2.8 suggested that it differs significantly from bovine cathepsin B and thus could be a good drug target. High throughput screening of a compound library against this enzyme and bovine cathepsin B in a counter assay identified four novel inhibitors, containing the warhead-types semicarbazone, thiosemicarbazone and triazine nitrile, that can be used as leads for antiparasite drug design. Covalent docking experiments confirmed the SARs of these lead compounds in an effort to understand the structural elements required for specific inhibition of CPB2.8. This study has provided starting points for the design of selective and highly potent inhibitors of L. mexicana cysteine protease CPB that may also have useful efficacy against other important cysteine proteases.

  11. Selective chromogenic and fluorogenic peptide substrates for the assay of cysteine peptidases in complex mixtures.

    Science.gov (United States)

    Semashko, Tatiana A; Vorotnikova, Elena A; Sharikova, Valeriya F; Vinokurov, Konstantin S; Smirnova, Yulia A; Dunaevsky, Yakov E; Belozersky, Mikhail A; Oppert, Brenda; Elpidina, Elena N; Filippova, Irina Y

    2014-03-15

    This study describes the design, synthesis, and use of selective peptide substrates for cysteine peptidases of the C1 papain family, important in many biological processes. The structure of the newly synthesized substrates is Glp-Xaa-Ala-Y (where Glp=pyroglutamyl; Xaa=Phe or Val; and Y=pNA [p-nitroanilide], AMC [4-amino-7-methylcoumaride], or AFC [4-amino-7-trifluoromethyl-coumaride]). Substrates were synthesized enzymatically to guarantee selectivity of the reaction and optical purity of the target compounds, simplifying the scheme of synthesis and isolation of products. The hydrolysis of the synthesized substrates was evaluated by C1 cysteine peptidases from different organisms and with different functions, including plant enzymes papain, bromelain, ficin, and mammalian lysosomal cathepsins B and L. The new substrates were selective for C1 cysteine peptidases and were not hydrolyzed by serine, aspartic, or metallo peptidases. We demonstrated an application of the selectivity of the synthesized substrates during the chromatographic separation of a multicomponent set of digestive peptidases from a beetle, Tenebrio molitor. Used in combination with the cysteine peptidase inhibitor E-64, these substrates were able to differentiate cysteine peptidases from peptidases of other classes in midgut extracts from T. molitor larvae and larvae of the genus Tribolium; thus, they are useful in the analysis of complex mixtures containing peptidases from different classes. Published by Elsevier Inc.

  12. Ga2O3 photocatalyzed on-line tagging of cysteine to facilitate peptide mass fingerprinting.

    Science.gov (United States)

    Qiao, Liang; Su, Fangzheng; Bi, Hongyan; Girault, Hubert H; Liu, Baohong

    2011-09-01

    β-Ga(2)O(3) is a wide-band-gap semiconductor having strong oxidation ability under light irradiation. Herein, the steel target plates modified with β-Ga(2)O(3) nanoparticles have been developed to carry out in-source photo-catalytic oxidative reactions for online peptide tagging during laser desorption/ionization mass spectrometry (LDI-MS) analysis. Under UV laser irradiation, β-Ga(2)O(3) can catalyze the photo-oxidation of 2-methoxyhydroquinone added to a sample mixture to 2-methoxy benzoquinone that can further react with the thiol groups of cysteine residues by Michael addition reaction. The tagging process leads to appearance of pairs of peaks with an m/z shift of 138.1Th. This online labelling strategy is demonstrated to be sensitive and efficient with a detection-limit at femtomole level. Using the strategy, the information on cysteine content in peptides can be obtained together with peptide mass, therefore constraining the database searching for an advanced identification of cysteine-containing proteins from protein mixtures. The current peptide online tagging method can be important for specific analysis of cysteine-containing proteins especially the low-abundant ones that cannot be completely isolated from other high-abundant non-cysteine-proteins. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. Cysteine Cathepsins as Regulators of the Cytotoxicity of NK and T Cells

    Science.gov (United States)

    Perišić Nanut, Milica; Sabotič, Jerica; Jewett, Anahid; Kos, Janko

    2014-01-01

    Cysteine cathepsins are lysosomal peptidases involved at different levels in the processes of the innate and adaptive immune responses. Some, such as cathepsins B, L, and H are expressed constitutively in most immune cells. In cells of innate immunity they play a role in cell adhesion and phagocytosis. Other cysteine cathepsins are expressed more specifically. Cathepsin X promotes dendritic cell maturation, adhesion of macrophages, and migration of T cells. Cathepsin S is implicated in major histocompatibility complex class II antigen presentation, whereas cathepsin C, expressed in cytotoxic T lymphocytes and natural killer (NK) cells, is involved in processing pro-granzymes into proteolytically active forms, which trigger cell death in their target cells. The activity of cysteine cathepsins is controlled by endogenous cystatins, cysteine protease inhibitors. Of these, cystatin F is the only cystatin that is localized in endosomal/lysosomal vesicles. After proteolytic removal of its N-terminal peptide, cystatin F becomes a potent inhibitor of cathepsin C with the potential to regulate pro-granzyme processing and cell cytotoxicity. This review is focused on the role of cysteine cathepsins and their inhibitors in the molecular mechanisms leading to the cytotoxic activity of T lymphocytes and NK cells in order to address new possibilities for regulation of their function in pathological processes. PMID:25520721

  14. Cysteine proteases as potential antigens in antiparasitic DNA vaccines

    DEFF Research Database (Denmark)

    Jørgensen, Louise von Gersdorff; Buchmann, Kurt

    2011-01-01

    En litteraturgennemgang af muligheder for at bruge cystein proteaser som antigener i antiparasitære vacciner.......En litteraturgennemgang af muligheder for at bruge cystein proteaser som antigener i antiparasitære vacciner....

  15. Open strings on AdS2 branes

    International Nuclear Information System (INIS)

    Lee, Peter; Ooguri, Hirosi.; Park, Jongwon; Tannenhauser, Jonathan

    2001-01-01

    We study the spectrum of open strings on AdS 2 branes in AdS 3 in an NS-NS background, using the SL(2,R) WZW model. When the brane carries no fundamental string charge, the open string spectrum is the holomorphic square root of the spectrum of closed strings in AdS 3 . It contains short and long strings, and is invariant under spectral flow. When the brane carries fundamental string charge, the open string spectrum again contains short and long strings in all winding sectors. However, branes with fundamental string charge break half the spectral flow symmetry. This has different implications for short and long strings. As the fundamental string charge increases, the brane approaches the boundary of AdS 3 . In this limit, the induced electric field on the worldvolume reaches its critical value, producing noncommutative open string theory on AdS 2

  16. 21 CFR 184.1271 - L-Cysteine.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true L-Cysteine. 184.1271 Section 184.1271 Food and... Substances Affirmed as GRAS § 184.1271 L-Cysteine. (a) L-Cysteine is the chemical L-2-amino-3... of total L-cysteine per 100 parts of flour in dough as a dough strengthener as defined in § 170.3(o...

  17. 21 CFR 184.1272 - L-Cysteine monohydrochloride.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true L-Cysteine monohydrochloride. 184.1272 Section 184... Listing of Specific Substances Affirmed as GRAS § 184.1272 L-Cysteine monohydrochloride. (a) L-Cysteine... ingredient is used to supply up to 0.009 part of total L-cysteine per 100 parts of flour in dough as a dough...

  18. Rotating strings in confining AdS/CFT backgrounds

    International Nuclear Information System (INIS)

    Armoni, Adi; Barbon, Jose L.F.; Petkou, Anastasios C.

    2002-01-01

    We study semiclassical rotating strings in AdS/CFT backgrounds that exhibit both confinement and finite-size effects. The energy versus spin dispersion relation for short strings is the expected Regge trajectory behaviour, with the same string tension as is measured by the Wilson loop. Long strings probe the interplay between confinement and finite-size effects. In particular, the dispersion relation for long strings shows a characteristic dependence on the string tension and the finite-size scale. (author)

  19. An equivalence between momentum and charge in string theory

    International Nuclear Information System (INIS)

    Horne, J.H.; Horowitz, G.T.; Steif, A.R.

    1992-01-01

    It is shown that for a translationally invariant solution to string theory, spacetime duality interchanges the momentum in the symmetry direction and the axion charge per unit length. As one application, we show explicitly that charged black strings are equivalent to boosted (uncharged) black strings. The extremal black strings (which correspond to the field outside of a fundamental macroscopic string) are equivalent to plane-fronted waves describing strings moving at the speed of light

  20. Topological amplitudes in string theory

    International Nuclear Information System (INIS)

    Antoniadis, I.; Taylor, T.R.

    1993-07-01

    We show that certain type II string amplitudes at genus g are given by the topological partition F g discussed recently by Bershadsky, Cecotti, Ooguri and Vafa. These amplitudes give rise to a term in the four-dimensional effective action of the form Σ g F g W 2g , where W is the chiral superfield of N = 2 supergravitational multiplet. The holomorphic anomaly of F g is related to non-localities of the effective action due to the propagation of massless states. This result generalizes the holomorphic anomaly of the one loop case which is known to lead to non-harmonic gravitational couplings. (author). 22 refs, 2 figs

  1. On the elliptic genus of three E-strings and heterotic strings

    International Nuclear Information System (INIS)

    Cai, Wenhe; Huang, Min-xin; Sun, Kaiwen

    2015-01-01

    A precise formula for the elliptic genus of three E-strings is presented. The related refined free energy coincides with the result calculated from topological string on local half K3 Calabi-Yau threefold up to genus twelve. The elliptic genus of three heterotic strings computed from M9 domain walls matches with the result from orbifold formula to high orders. This confirms the n=3 case of the recent conjecture that n pairs of E-strings can recombine into n heterotic strings.

  2. Boundary string field theory and an open string one-loop

    International Nuclear Information System (INIS)

    Lee, Tae Jin; Viswanathan, K. S.; Yang, Yi

    2003-01-01

    We discuss the open string one-loop partition function in the tachyon condensation background of an unstable D-brane system. We evaluate the partition function by using the boundary-state formulation and find that it is in complete agreement with the result obtained in the boundary string field theory. This suggests that the open string higher loop diagrams may be produced consistently by using a closed string field theory, where the D-brane plays the role of a source for the closed string field

  3. A Note on Tensionless Strings in M-Theory

    OpenAIRE

    Davis, K.

    1996-01-01

    In this article we examine the appearance of tensionless strings in M-Theory. We subsequently interpret these tensionless strings in a String Theory context. In particular, we examine tensionless strings appearing in M-Theory on $S^{1}$, M-Theory on $S^{1} / {\\bf Z}_{2}$, and M-Theory on $T^{2}$; we then interpret the appearance of such strings in a String Theory context. Then we reverse this process and examine the appearance of some tensionless strings in String Theory. Subsequently we inte...

  4. BPS limit of multi- D- and DF-strings in boundary string field theory

    International Nuclear Information System (INIS)

    Go, Gyungchoon; Ishida, Akira; Kim, Yoonbai

    2007-01-01

    A BPS limit is systematically derived for straight multi- D- and DF-strings from the D3D-bar3 system in the context of boundary superstring field theory. The BPS limit is obtained in the limit of thin D(F)-strings, where the Bogomolny equation supports singular static multi-D(F)-string solutions. For the BPS multi-string configurations with arbitrary separations, BPS sum rule is fulfilled under a Gaussian type tachyon potential and reproduces exactly the descent relation. For the DF-strings ((p,q)-strings), the distribution of fundamental string charge density coincides with its energy density and the Hamiltonian density takes the BPS formula of square-root form

  5. Bonder for Solar-Cell Strings

    Science.gov (United States)

    Garwood, G.; Frasch, W.

    1982-01-01

    String bonder for solar-cell arrays eliminates tedious manual assembly procedure that could damage cell face. Vacuum arm picks up face-down cell from cell-inverting work station and transfers it to string conveyor without changing cell orientation. Arm is activated by signal from microprocessor.

  6. Extremal black holes as exact string solutions

    International Nuclear Information System (INIS)

    Horowitz, G.T.; Tseytlin, A.A.

    1994-01-01

    We show that the leading order solution describing an extremal electrically charged black hole in string theory is, in fact, an exact solution to all orders in α' when interpreted in a Kaluza-Klein fashion. This follows from the observation that it can be obtained via dimensional reduction from a five-dimensional background which is proved to be an exact string solution

  7. Covariantly second-quantized string. Pt. 2

    International Nuclear Information System (INIS)

    Siegel, W.

    1984-01-01

    BRST invariance is used to second-quantize the interacting relativistic string. The zero-mode of the anticommuting string variables is identified as the Grassmann coordinate of BRST superfields. The massless sector is Yang-Mills theory in the usual Faddeev-Popov formalism. (orig.)

  8. A Computer String-Grammar of English.

    Science.gov (United States)

    Sager, Naomi

    This volume is the fourth in a series of detailed reports on a working computer program for the syntactic analysis of English sentences into their component strings. The report (1) records the considerations involved in various decisions among alternative grammatical formulations and presents the word-subclasses, the linguistic strings, etc., for…

  9. Total cross section of highly excited strings

    International Nuclear Information System (INIS)

    Lizzi, F.; Senda, I.

    1990-01-01

    The unpolarized total cross section for the joining of two highly excited strings is calculated. The calculation is performed by taking the average overall states in the given excitation levels of the initial strings. We find that the total cross section grows with the energy and momentum of the initial states. (author). 8 refs, 1 fig

  10. Querying and Mining Strings Made Easy

    KAUST Repository

    Sahli, Majed

    2017-10-13

    With the advent of large string datasets in several scientific and business applications, there is a growing need to perform ad-hoc analysis on strings. Currently, strings are stored, managed, and queried using procedural codes. This limits users to certain operations supported by existing procedural applications and requires manual query planning with limited tuning opportunities. This paper presents StarQL, a generic and declarative query language for strings. StarQL is based on a native string data model that allows StarQL to support a large variety of string operations and provide semantic-based query optimization. String analytic queries are too intricate to be solved on one machine. Therefore, we propose a scalable and efficient data structure that allows StarQL implementations to handle large sets of strings and utilize large computing infrastructures. Our evaluation shows that StarQL is able to express workloads of application-specific tools, such as BLAST and KAT in bioinformatics, and to mine Wikipedia text for interesting patterns using declarative queries. Furthermore, the StarQL query optimizer shows an order of magnitude reduction in query execution time.

  11. Confining strings revisited - a short comment

    International Nuclear Information System (INIS)

    Botelho, Luiz C.L.

    2000-03-01

    We show that Polyakov's confining string Nucl. Phys. B486, (1997) 23, is the author's previously proposed self-avoiding extrinsic strings (Luiz C.L. Botelho), Rev. Bras. Fis. 16, 279, (1986); CALTECH-preprint 68, 1444, (1987); J. Math. Phys. 30 (9), (1989), 2160). (author)

  12. String Theory: Big Problem for Small Size

    Science.gov (United States)

    Sahoo, S.

    2009-01-01

    String theory is the most promising candidate theory for a unified description of all the fundamental forces that exist in nature. It provides a mathematical framework that combines quantum theory with Einstein's general theory of relativity. The typical size of a string is of the order of 10[superscript -33] cm, called the Planck length. But due…

  13. Plucked String on a Shoestring Budget

    Science.gov (United States)

    Gluck, Paul

    2009-01-01

    The physics of the plucked string has been treated in many articles and books. For our 12th-grade high school physics laboratory, we have built a cheap, simple sonometer apparatus for each pair of students on which they may investigate some interesting phenomena that arise when a string is plucked. Among these are the generation of harmonics…

  14. String fragmentation; La fragmentation des cordes

    Energy Technology Data Exchange (ETDEWEB)

    Drescher, H.J.; Werner, K. [Laboratoire de Physique Subatomique et des Technologies Associees - SUBATECH, Centre National de la Recherche Scientifique, 44 - Nantes (France)

    1997-10-01

    The classical string model is used in VENUS as a fragmentation model. For the soft domain simple 2-parton strings were sufficient, whereas for higher energies up to LHC, the perturbative regime of the QCD gives additional soft gluons, which are mapped on the string as so called kinks, energy singularities between the leading partons. The kinky string model is chosen to handle fragmentation of these strings by application of the Lorentz invariant area law. The `kinky strings` model, corresponding to the perturbative gluons coming from pQCD, takes into consideration this effect by treating the partons and gluons on the same footing. The decay law is always the Artru-Menessier area law which is the most realistic since it is invariant to the Lorentz and gauge transformations. For low mass strings a manipulation of the rupture point is necessary if the string corresponds already to an elementary particle determined by the mass and the flavor content. By means of the fragmentation model it will be possible to simulate the data from future experiments at LHC and RHIC 3 refs.

  15. EFFECTIVE ACTIONS FOR HETEROTIC STRING THEORY

    NARCIS (Netherlands)

    SUELMANN, H

    Heterotic String Theory is an attempt to construct a description of nature that is more satisfying than the Standard Model. A major problem is that it is very difficult to do explicit calculations in string theory. Therefore, it is useful to construct a 'normal' field theory that approximates HST.

  16. String loop effect on the BRST charge

    International Nuclear Information System (INIS)

    Das, A.; Nishino, H.

    1987-07-01

    An effective BRST charge Q BRST which incorporates the string one-loop corrections is presented for the closed bosonic string in an arbitrary background. The effective σ-model action which leads to such a Q BRST is obtained and some consequences are discussed. (author). 14 refs, 1 fig

  17. Calculations in perturbative string field theory

    International Nuclear Information System (INIS)

    Thorn, C.B.

    1987-01-01

    The author discusses methods for evaluating the Feynman diagrams of string field theory, with particular emphasis on Witten's version of open string field theory. It is explained in some detail how the rules states by Giddings and Martinec for relating a given diagram to a Polyakov path integral emerge from the Feynman rules

  18. Symbol-String Sensitivity and Children's Reading

    Science.gov (United States)

    Pammer, Kristen; Lavis, Ruth; Hansen, Peter; Cornelissen, Piers L.

    2004-01-01

    In this study of primary school children, a novel "symbol-string" task is used to assess sensitivity to the position of briefly presented non-alphabetic but letter-like symbols. The results demonstrate that sensitivity in the symbol-string task explains a unique proportion of the variability in children's contextual reading accuracy. Moreover,…

  19. Cosmic R-string in thermal history

    Energy Technology Data Exchange (ETDEWEB)

    Kamada, Kohei [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Kobayashi, Tatsuo [Kyoto Univ. (Japan). Dept. of Physics; Ohashi, Keisuke [Osaka City Univ. (Japan). Dept. of Mathematics and Physics; Ookouchi, Yutaka [Kyoto Univ. (Japan). Dept. of Physics; Kyoto Univ. (Japan). The Hakubi Center for Advanced Research

    2013-03-15

    We study stabilization of an unstable cosmic string associated with spontaneously broken U(1){sub R} symmetry, which otherwise causes a dangerous roll-over process. We demonstrate that in a gauge mediation model, messengers can receive enough corrections from the thermal plasma of the supersymmetric standard model particles to stabilize the unstable modes of the string.

  20. Ultrasensitive string-based temperature sensors

    DEFF Research Database (Denmark)

    Larsen, Tom; Schmid, Silvan; Gronberg, L.

    2011-01-01

    Resonant strings are a promising concept for ultra sensitive temperature detection. We present an analytical model for the sensitivity with which we optimize the temperature response of resonant strings by varying geometry and material. The temperature sensitivity of silicon nitride and aluminum ...

  1. Effective lagrangian from bosonic string field theory

    International Nuclear Information System (INIS)

    Nakazawa, Naohito

    1987-01-01

    We investigate the low-energy effective action from the string field theoretical view point. The low-energy effective lagrangian for the massless mode of bosonic string is determined to the order of α'. We find a term which can not be determined from the S-matrix approach. (author)

  2. String field representation of the Virasoro algebra

    Czech Academy of Sciences Publication Activity Database

    Mertes, N.; Schnabl, Martin

    2016-01-01

    Roč. 2016, č. 12 (2016), 1-14, č. článku 151. ISSN 1029-8479 R&D Projects: GA ČR(CZ) GA14-31689S Institutional support: RVO:68378271 Keywords : String Held Theory * Conformal Field Models in String Theory Subject RIV: BE - Theoretical Physics Impact factor: 6.063, year: 2016

  3. Universal moduli space and string theory

    International Nuclear Information System (INIS)

    Schwarz, A.S.

    1989-09-01

    The construction of the universal supermoduli space is given. The super-Mumford form (the holomorphic square root from the string measure) is extended to the universal supermoduli space and expressed through the superanalog of Sato's τ-function. The hidden N=2 superconformal symmetry in the string theory is considered. (author). 13 refs

  4. String 2, test facility for the LHC

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    String 2 is the long chain seen to the right, representing one complete cell of bending dipoles, focusing quadrupoles and corrector magnets. On 17 June 2002 the test string reached the nominal running current of 11 860 A and magnetic field of 8.335 T for the LHC.

  5. 5D Black Holes and Matrix Strings

    CERN Document Server

    Dijkgraaf, R; Verlinde, Herman L

    1997-01-01

    We derive the world-volume theory, the (non)-extremal entropy and background geometry of black holes and black strings constructed out of the NS IIA fivebrane within the framework of matrix theory. The CFT description of strings propagating in the black hole geometry arises as an effective field theory.

  6. Quantum Geometry of Refined Topological Strings

    NARCIS (Netherlands)

    Aganagic, M.; Cheng, M.C.N.; Dijkgraaf, R.; Kreft, D.; Vafa, C.

    2012-01-01

    We consider branes in refined topological strings. We argue that their wavefunctions satisfy a Schrödinger equation depending on multiple times and prove this in the case where the topological string has a dual matrix model description. Furthermore, in the limit where one of the equivariant

  7. Wavy strings: Black or bright?

    International Nuclear Information System (INIS)

    Kaloper, N.; Myers, R.C.; Roussel, H.

    1997-01-01

    Recent developments in string theory have brought forth considerable interest in time-dependent hair on extended objects. This novel new hair is typically characterized by a wave profile along the horizon and angular momentum quantum numbers l,m in the transverse space. In this work, we present an extensive treatment of such oscillating black objects, focusing on their geometric properties. We first give a theorem of purely geometric nature, stating that such wavy hair cannot be detected by any scalar invariant built out of the curvature and/or matter fields. However, we show that the tidal forces detected by an infalling observer diverge at the open-quotes horizonclose quotes of a black string superposed with a vibration in any mode with l≥1. The same argument applied to longitudinal (l=0) waves detects only finite leading-order tidal forces. We also provide an example with a manifestly smooth metric, proving that at least a certain class of these longitudinal waves have regular horizons. copyright 1997 The American Physical Society

  8. Eisenstein series and string thresholds

    International Nuclear Information System (INIS)

    Obers, N.A.; Pioline, B.

    2000-01-01

    We investigate the relevance of Eisenstein series for representing certain G(Z)-invariant string theory amplitudes which receive corrections from BPS states only. G(Z) may stand for any of the mapping class, T-duality and U-duality groups Sl(d,Z), SO(d,d,Z) or E d+1(d+1) (Z) respectively. Using G(Z)-invariant mass formulae, we construct invariant modular functions on the symmetric space K backslash G(R) of non-compact type, with K the maximal compact subgroup of G(R), that generalize the standard non-holomorphic Eisenstein series arising in harmonic analysis on the fundamental domain of the Poincare upper half-plane. Comparing the asymptotics and eigenvalues of the Eisenstein series under second order differential operators with quantities arising in one- and g-loop string amplitudes, we obtain a manifestly T-duality invariant representation of the latter, conjecture their non-perturbative U-duality invariant extension, and analyze the resulting non-perturbative effects. This includes the R 4 and R 4 H -4 g -4 couplings in toroidal compactifications of M-theory to any dimension D≥4 and D≥6 respectively. (orig.)

  9. Observing string breaking with Wilson loops

    CERN Document Server

    Kratochvila, S; Kratochvila, Slavo; Forcrand, Philippe de

    2003-01-01

    An uncontroversial observation of adjoint string breaking is proposed, while measuring the static potential from Wilson loops only. The overlap of the Wilson loop with the broken-string state is small, but non-vanishing, so that the broken-string groundstate can be seen if the Wilson loop is long enough. We demonstrate this in the context of the (2+1)d SU(2) adjoint static potential, using an improved version of the Luscher-Weisz exponential variance reduction. To complete the picture we perform the more usual multichannel analysis with two basis states, the unbroken-string state and the broken-string state (two so-called gluelumps). As by-products, we obtain the temperature-dependent static potential measured from Polyakov loop correlations, and the fundamental SU(2) static potential with improved accuracy. Comparing the latter with the adjoint potential, we see clear deviations from Casimir scaling.

  10. String theory of the Regge intercept.

    Science.gov (United States)

    Hellerman, S; Swanson, I

    2015-03-20

    Using the Polchinski-Strominger effective string theory in the covariant gauge, we compute the mass of a rotating string in D dimensions with large angular momenta J, in one or two planes, in fixed ratio, up to and including first subleading order in the large J expansion. This constitutes a first-principles calculation of the value for the order-J(0) contribution to the mass squared of a meson on the leading Regge trajectory in planar QCD with bosonic quarks. For open strings with Neumann boundary conditions, and for closed strings in D≥5, the order-J(0) term in the mass squared is exactly calculated by the semiclassical approximation. This term in the expansion is universal and independent of the details of the theory, assuming only D-dimensional Poincaré invariance and the absence of other infinite-range excitations on the string world volume, beyond the Nambu-Goldstone bosons.

  11. Correspondence principle for black holes and strings

    International Nuclear Information System (INIS)

    Horowitz, G.T.; Polchinski, J.

    1997-01-01

    For most black holes in string theory, the Schwarzschild radius in string units decreases as the string coupling is reduced. We formulate a correspondence principle, which states that (i) when the size of the horizon drops below the size of a string, the typical black hole state becomes a typical state of strings and D-branes with the same charges, and (ii) the mass does not change abruptly during the transition. This provides a statistical interpretation of black hole entropy. This approach does not yield the numerical coefficient, but gives the correct dependence on mass and charge in a wide range of cases, including neutral black holes. copyright 1997 The American Physical Society

  12. Field theory of relativistic strings: I. Trees

    International Nuclear Information System (INIS)

    Kaku, M.; Kikkawa, K.

    1985-01-01

    The authors present an entirely new kind of field theory, a field theory quantized not at space-time points, but quantized along an extended set of multilocal points on a string. This represents a significant departure from the usual quantum field theory, whose free theory represents a definite set of elementary particles, because the field theory on relativistic strings can accommodate an infinite set of linearly rising Regge trajectories. In this paper, the authors (1) present canonical quantization and the Green's function of the free string, (2) introduce three-string interactions, (3) resolve the question of multiple counting, (4) complete the counting arguments for all N-point trees, and (5) introduce four-string interactions which yield a Yang-Mills structure when the zero-slope limit is taken

  13. Notes on entanglement entropy in string theory

    International Nuclear Information System (INIS)

    He, Song; Numasawa, Tokiro; Takayanagi, Tadashi; Watanabe, Kento

    2015-01-01

    In this paper, we study the conical entropy in string theory in the simplest setup of dividing the nine dimensional space into two halves. This corresponds to the leading quantum correction to the horizon entropy in string theory on the Rindler space. This entropy is also called the conical entropy and includes surface term contributions. We first derive a new simple formula of the conical entropy for any free higher spin fields. Then we apply this formula to computations of conical entropy in open and closed superstring. In our analysis of closed string, we study the twisted conical entropy defined by making use of string theory on Melvin backgrounds. This quantity is easier to calculate owing to the folding trick. Our analysis shows that the conical entropy in closed superstring is UV finite owing to the string scale cutoff.

  14. The strings connection: MSSM-like models from strings

    Energy Technology Data Exchange (ETDEWEB)

    Nilles, Hans Peter [Bethe Center for Theoretical Physics (BCTP) and Physikalisches Institut der Universitaet Bonn, Bonn (Germany)

    2014-05-15

    String theory constructions towards the MSSM allow us to identify some general properties that could be relevant for tests at the LHC. They originate from the geometric structure of compactification and the location of fields in extra-dimensional space. Within the framework of the heterotic MiniLandscape we extract some generic lessons for supersymmetric model building. Among them is a specific pattern of SUSY breakdown based on mirage mediation and remnants of extended supersymmetry. This leads to a split spectrum with heavy scalars of the first two families of quarks and leptons and suppressed masses for gauginos, top partners and Higgs bosons. The models exhibit some specific form of hidden supersymmetry consistent with the high mass of the Higgs boson and all presently available experimental constraints. The most compelling picture is based on precision gauge coupling unification that might be in the kinematic reach of the LHC. (orig.)

  15. L-Cysteine Metabolism and Fermentation in Microorganisms.

    Science.gov (United States)

    Takagi, Hiroshi; Ohtsu, Iwao

    L-Cysteine is an important amino acid both biologically and commercially. Although most amino acids are industrially produced by microbial fermentation, L-cysteine has been mainly produced by protein hydrolysis. Due to environmental and safety problems, synthetic or biotechnological products have been preferred in the market. Here, we reviewed L-cysteine metabolism, including biosynthesis, degradation, and transport, and biotechnological production (including both enzymatic and fermentation processes) of L-cysteine. The metabolic regulation of L-cysteine including novel sulfur metabolic pathways found in microorganisms is also discussed. Recent advancement in biochemical studies, genome sequencing, structural biology, and metabolome analysis has enabled us to use various approaches to achieve direct fermentation of L-cysteine from glucose. For example, worldwide companies began to supply L-cysteine and its derivatives produced by bacterial fermentation. These companies successfully optimized the original metabolism of their private strains. Basically, a combination of three factors should be required for improving L-cysteine fermentation: that is, (1) enhancing biosynthesis: overexpression of the altered cysE gene encoding feedback inhibition-insensitive L-serine O-acetyltransferase (SAT), (2) weakening degradation: knockout of the genes encoding L-cysteine desulfhydrases, and (3) exploiting export system: overexpression of the gene involved in L-cysteine transport. Moreover, we found that "thiosulfate" is much more effective sulfur source than commonly used "sulfate" for L-cysteine production in Escherichia coli, because thiosulfate is advantageous for saving consumption of NADPH and relating energy molecules.

  16. [Plant signaling peptides. Cysteine-rich peptides].

    Science.gov (United States)

    Ostrowski, Maciej; Kowalczyk, Stanisław

    2015-01-01

    Recent bioinformatic and genetic analyses of several model plant genomes have revealed the existence of a highly abundant group of signaling peptides that are defined as cysteine-rich peptides (CRPs). CRPs are usually in size between 50 and 90 amino acid residues, they are positively charged, and they contain 4-16 cysteine residues that are important for the correct conformational folding. Despite the structural differences among CRP classes, members from each class have striking similarities in their molecular properties and function. The present review presents the recent progress in research on signaling peptides from several families including: EPF/EPFL, SP11/SCR, PrsS, RALF, LURE, and some other peptides belonging to CRP group. There is convincing evidence indicating multiple roles for these CRPs as signaling molecules during the plant life cycle, ranging from stomata development and patterning, self-incompatibility, pollen tube growth and guidance, reproductive processes, and nodule formation.

  17. Experiences with string matching on the Fermi Architecture

    Energy Technology Data Exchange (ETDEWEB)

    Tumeo, Antonino; Secchi, Simone; Villa, Oreste

    2011-02-25

    String matching is at the core of many real-world applications, such as security, bioinformatic, data mining. All these applications requires the ability to match always growing data sets against large dictionaries effectively, fastly and possibly in real time. Unfortunately, string matching is a computationally intensive procedure which poses significant challenges on current software and hardware implementations. Graphic Processing Units (GPU) have become an interesting target for such high-throughput applications, but the algorithms and the data structures need to be redesigned to be parallelized and adapted to the underlining hardware, coping with the limitations imposed by these architectures. In this paper we present an efficient implementation of the Aho-Corasick string matching algorithm on GPU, showing how we progressively redesigned the algorithm and the data structures to fit on the architecture. We then evaluate the implementation on single and multiple Tesla C2050 (T20 ``Fermi'' based) boards, comparing them to the previous Tesla C1060 (T10 based) solutions and equivalent multicore implementations on x86 CPUs. We discuss the various tradeoffs of the different architectures.

  18. Document retrieval on repetitive string collections.

    Science.gov (United States)

    Gagie, Travis; Hartikainen, Aleksi; Karhu, Kalle; Kärkkäinen, Juha; Navarro, Gonzalo; Puglisi, Simon J; Sirén, Jouni

    2017-01-01

    Most of the fastest-growing string collections today are repetitive, that is, most of the constituent documents are similar to many others. As these collections keep growing, a key approach to handling them is to exploit their repetitiveness, which can reduce their space usage by orders of magnitude. We study the problem of indexing repetitive string collections in order to perform efficient document retrieval operations on them. Document retrieval problems are routinely solved by search engines on large natural language collections, but the techniques are less developed on generic string collections. The case of repetitive string collections is even less understood, and there are very few existing solutions. We develop two novel ideas, interleaved LCPs and precomputed document lists , that yield highly compressed indexes solving the problem of document listing (find all the documents where a string appears), top- k document retrieval (find the k documents where a string appears most often), and document counting (count the number of documents where a string appears). We also show that a classical data structure supporting the latter query becomes highly compressible on repetitive data. Finally, we show how the tools we developed can be combined to solve ranked conjunctive and disjunctive multi-term queries under the simple [Formula: see text] model of relevance. We thoroughly evaluate the resulting techniques in various real-life repetitiveness scenarios, and recommend the best choices for each case.

  19. Worldsheet factorization for twistor-strings

    Energy Technology Data Exchange (ETDEWEB)

    Adamo, Tim [Department of Applied Mathematics & Theoretical Physics, University of Cambridge, Wilberforce Road, Cambridge CB3 0WA (United Kingdom)

    2014-04-10

    We study the multiparticle factorization properties of two worldsheet theories which — at tree-level — describe the scattering of massless particles in four dimensions: the Berkovits-Witten twistor-string for N=4 super-Yang-Mills coupled to N=4 conformal supergravity, and the Skinner twistor-string for N=8 supergravity. By considering these string-like theories, we can study factorization at the level of the worldsheet before any Wick contractions or integrals have been performed; this is much simpler than considering the factorization properties of the amplitudes themselves. In Skinner’s twistor-string this entails the addition of worldsheet gravity as well as a formalism that represents all external states in a manifestly symmetric way, which we develop explicitly at genus zero. We confirm that the scattering amplitudes of Skinner’s theory, as well as the gauge theory amplitudes for the planar sector of the Berkovits-Witten theory, factorize appropriately at genus zero. In the non-planar sector, we find behavior indicative of conformal gravity in the Berkovits-Witten twistor-string. We contrast factorization in twistor-strings with the story in ordinary string theory, and also make some remarks on higher genus factorization and disconnected prescriptions.

  20. Worldsheet factorization for twistor-strings

    International Nuclear Information System (INIS)

    Adamo, Tim

    2014-01-01

    We study the multiparticle factorization properties of two worldsheet theories which — at tree-level — describe the scattering of massless particles in four dimensions: the Berkovits-Witten twistor-string for N=4 super-Yang-Mills coupled to N=4 conformal supergravity, and the Skinner twistor-string for N=8 supergravity. By considering these string-like theories, we can study factorization at the level of the worldsheet before any Wick contractions or integrals have been performed; this is much simpler than considering the factorization properties of the amplitudes themselves. In Skinner’s twistor-string this entails the addition of worldsheet gravity as well as a formalism that represents all external states in a manifestly symmetric way, which we develop explicitly at genus zero. We confirm that the scattering amplitudes of Skinner’s theory, as well as the gauge theory amplitudes for the planar sector of the Berkovits-Witten theory, factorize appropriately at genus zero. In the non-planar sector, we find behavior indicative of conformal gravity in the Berkovits-Witten twistor-string. We contrast factorization in twistor-strings with the story in ordinary string theory, and also make some remarks on higher genus factorization and disconnected prescriptions

  1. Gauge and general covariance of string interactions

    International Nuclear Information System (INIS)

    Das, S.R.

    1986-01-01

    All fundamental interactions at observable energies seem to arise out of local symmetries - gauge invariances and general coordinate invariance. In usual field theories of point particles these invariances are postulated a priori: the idea is to deduce everything else from the symmetry group and the representation content of the matter fields. In string theories, the situation is rather different. Here the basic principle is reparametrization invariance on the world sheet swept out by the string. The authors consider the simplest string models-those defined on flat Minkowski space-time. The transverse oscillations of the string lead to an infinite tower of modes which may be thought of as the ''particles'' constituting the string. The interacting string theory is defined, in the first quantized formulation, by specifying the interaction of these modes with the string. These interaction vertices must satisfy a basic requirement: when any dual amplitude is factorized only physical states (i.e. those satisfying the Virasoro conditions) must occur as on-mass-shell intermediate states. This means that the vertices respect the reparametrization invariance of the world sheet, since it is this symmetry which eliminates ghost states by virtue of Virasoro conditions

  2. String-Corrected Black Holes

    Energy Technology Data Exchange (ETDEWEB)

    Hubeny, V.

    2005-01-12

    We investigate the geometry of four dimensional black hole solutions in the presence of stringy higher curvature corrections to the low energy effective action. For certain supersymmetric two charge black holes these corrections drastically alter the causal structure of the solution, converting seemingly pathological null singularities into timelike singularities hidden behind a finite area horizon. We establish, analytically and numerically, that the string-corrected two-charge black hole metric has the same Penrose diagram as the extremal four-charge black hole. The higher derivative terms lead to another dramatic effect--the gravitational force exerted by a black hole on an inertial observer is no longer purely attractive. The magnitude of this effect is related to the size of the compactification manifold.

  3. The birth of string theory

    CERN Document Server

    Castellani, Elena; Colomo, Filippo; Di Vecchia, Paolo

    2012-01-01

    String theory is currently the best candidate for a unified theory of all forces and all forms of matter in nature. As such, it has become a focal point for physical and philosophical discussions. This unique book explores the history of the theory's early stages of development, as told by its main protagonists. The book journeys from the first version of the theory (the so-called dual resonance model) in the late sixties, as an attempt to describe the physics of strong interactions outside the framework of quantum field theory, to its reinterpretation around the mid-seventies as a quantum theory of gravity unified with the other forces, and its successive developments up to the superstring revolution in 1984. Providing important background information to current debates on the theory, this book is essential reading for students and researchers in physics, as well as historians and philosophers of science.

  4. Optimal shapes of compact strings

    International Nuclear Information System (INIS)

    Maritan, A.; Micheletti, C.; Trovato, A.; Banavar, J.R.

    2000-07-01

    Optimal geometrical arrangements, such as the stacking of atoms, are of relevance in diverse disciplines. A classic problem is the determination of the optimal arrangement of spheres in three dimensions in order to achieve the highest packing fraction; only recently has it been proved that the answer for infinite systems is a face-centred-cubic lattice. This simply stated problem has had a profound impact in many areas, ranging from the crystallization and melting of atomic systems, to optimal packing of objects and subdivision of space. Here we study an analogous problem-that of determining the optimal shapes of closely packed compact strings. This problem is a mathematical idealization of situations commonly encountered in biology, chemistry and physics, involving the optimal structure of folded polymeric chains. We find that, in cases where boundary effects are not dominant, helices with a particular pitch-radius ratio are selected. Interestingly, the same geometry is observed in helices in naturally-occurring proteins. (author)

  5. Geometric Transitions, Topological Strings, and Generalized Complex Geometry

    International Nuclear Information System (INIS)

    Chuang, Wu-yen

    2007-01-01

    Mirror symmetry is one of the most beautiful symmetries in string theory. It helps us very effectively gain insights into non-perturbative worldsheet instanton effects. It was also shown that the study of mirror symmetry for Calabi-Yau flux compactification leads us to the territory of ''Non-Kaehlerity''. In this thesis we demonstrate how to construct a new class of symplectic non-Kaehler and complex non-Kaehler string theory vacua via generalized geometric transitions. The class admits a mirror pairing by construction. From a variety of sources, including super-gravity analysis and KK reduction on SU(3) structure manifolds, we conclude that string theory connects Calabi-Yau spaces to both complex non-Kaehler and symplectic non-Kaehler manifolds and the resulting manifolds lie in generalized complex geometry. We go on to study the topological twisted models on a class of generalized complex geometry, bi-Hermitian geometry, which is the most general target space for (2, 2) world-sheet theory with non-trivial H flux turned on. We show that the usual Kaehler A and B models are generalized in a natural way. Since the gauged supergravity is the low energy effective theory for the compactifications on generalized geometries, we study the fate of flux-induced isometry gauging in N = 2 IIA and heterotic strings under non-perturbative instanton effects. Interestingly, we find we have protection mechanisms preventing the corrections to the hyper moduli spaces. Besides generalized geometries, we also discuss the possibility of new NS-NS fluxes in a new doubled formalism

  6. Geometric Transitions, Topological Strings, and Generalized Complex Geometry

    Energy Technology Data Exchange (ETDEWEB)

    Chuang, Wu-yen; /SLAC /Stanford U., Phys. Dept.

    2007-06-29

    Mirror symmetry is one of the most beautiful symmetries in string theory. It helps us very effectively gain insights into non-perturbative worldsheet instanton effects. It was also shown that the study of mirror symmetry for Calabi-Yau flux compactification leads us to the territory of ''Non-Kaehlerity''. In this thesis we demonstrate how to construct a new class of symplectic non-Kaehler and complex non-Kaehler string theory vacua via generalized geometric transitions. The class admits a mirror pairing by construction. From a variety of sources, including super-gravity analysis and KK reduction on SU(3) structure manifolds, we conclude that string theory connects Calabi-Yau spaces to both complex non-Kaehler and symplectic non-Kaehler manifolds and the resulting manifolds lie in generalized complex geometry. We go on to study the topological twisted models on a class of generalized complex geometry, bi-Hermitian geometry, which is the most general target space for (2, 2) world-sheet theory with non-trivial H flux turned on. We show that the usual Kaehler A and B models are generalized in a natural way. Since the gauged supergravity is the low energy effective theory for the compactifications on generalized geometries, we study the fate of flux-induced isometry gauging in N = 2 IIA and heterotic strings under non-perturbative instanton effects. Interestingly, we find we have protection mechanisms preventing the corrections to the hyper moduli spaces. Besides generalized geometries, we also discuss the possibility of new NS-NS fluxes in a new doubled formalism.

  7. Reheating for closed string inflation

    Energy Technology Data Exchange (ETDEWEB)

    Cicoli, Michele [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Mazumdar, Anupam [Lancaster Univ. (United Kingdom). Physics Dept.; Copenhagen Univ. (Denmark). Niels Bohr Institute

    2010-05-15

    We point out some of the outstanding challenges for embedding inflationary cosmology within string theory studying the process of reheating for models where the inflaton is a closed string mode parameterising the size of an internal cycle of the compactification manifold. A realistic model of inflation must explain the tiny perturbations in the cosmic microwave background radiation and also how to excite the ordinary matter degrees of freedom after inflation, required for the success of Big Bang Nucleosynthesis. We study these issues focusing on two promising inflationary models embedded in LARGE volume type IIB flux compactifications. We show that phenomenological requirements and consistency of the effective field theory treatment imply the presence at low energies of a hidden sector together with a visible sector, where the Minimal Supersymmetric Standard Model fields are residing. A detailed calculation of the inflaton coupling to the fields of the hidden sector, visible sector, and moduli sector, reveals that the inflaton fails to excite primarily the visible sector fields, instead hidden sector fields are excited copiously after the end of inflation. This sets severe constraints on hidden sector model building where the most promising scenario emerges as a pure N=1 SYM theory, forbidding the kinematical decay of the inflaton to the hidden sector. In this case it is possible to reheat the Universe with the visible degrees of freedom even though in some cases we discover a new tension between TeV scale SUSY and reheating on top of the well-known tension between TeV scale SUSY and inflation. (orig.)

  8. Planckian axions in string theory

    International Nuclear Information System (INIS)

    Bachlechner, Thomas C.; Long, Cody; McAllister, Liam

    2015-01-01

    We argue that super-Planckian diameters of axion fundamental domains can arise in Calabi-Yau compactifications of string theory. In a theory with N axions θ i , the fundamental domain is a polytope defined by the periodicities of the axions, via constraints of the form −π√N. This result is robust in the presence of P>N constraints, while for P=N the diameter is further enhanced by eigenvector delocalization to N 3/2 f N . We directly verify our results in explicit Calabi-Yau compactifications of type IIB string theory. In the classic example with h 1,1 =51 where parametrically controlled moduli stabilization was demonstrated by Denef et al. in http://dx.doi.org/10.4310/ATMP.2005.v9.n6.a1, the largest metric eigenvalue obeys f N ≈0.013M pl . The random matrix analysis then predicts, and we exhibit, axion diameters ≈M pl for the precise vacuum parameters found in http://dx.doi.org/10.4310/ATMP.2005.v9.n6.a1. Our results provide a framework for pursuing large-field axion inflation in well-understood flux vacua.

  9. Reheating for closed string inflation

    International Nuclear Information System (INIS)

    Cicoli, Michele; Mazumdar, Anupam; Copenhagen Univ.

    2010-05-01

    We point out some of the outstanding challenges for embedding inflationary cosmology within string theory studying the process of reheating for models where the inflaton is a closed string mode parameterising the size of an internal cycle of the compactification manifold. A realistic model of inflation must explain the tiny perturbations in the cosmic microwave background radiation and also how to excite the ordinary matter degrees of freedom after inflation, required for the success of Big Bang Nucleosynthesis. We study these issues focusing on two promising inflationary models embedded in LARGE volume type IIB flux compactifications. We show that phenomenological requirements and consistency of the effective field theory treatment imply the presence at low energies of a hidden sector together with a visible sector, where the Minimal Supersymmetric Standard Model fields are residing. A detailed calculation of the inflaton coupling to the fields of the hidden sector, visible sector, and moduli sector, reveals that the inflaton fails to excite primarily the visible sector fields, instead hidden sector fields are excited copiously after the end of inflation. This sets severe constraints on hidden sector model building where the most promising scenario emerges as a pure N=1 SYM theory, forbidding the kinematical decay of the inflaton to the hidden sector. In this case it is possible to reheat the Universe with the visible degrees of freedom even though in some cases we discover a new tension between TeV scale SUSY and reheating on top of the well-known tension between TeV scale SUSY and inflation. (orig.)

  10. Drill-string design for directional wells

    Energy Technology Data Exchange (ETDEWEB)

    Dawson, R; Corbett, K T [Exxon Production Research Co., Houston, TX (USA)

    1983-01-01

    This paper is concerned with predicting the tension and torsion loads on drill strings in directional wells and with adjusting the string design or well plan to provide adequate strength. Drill-string drag is the incremental force that is required to move the pipe up or down in the hole; torque is the moment required to rotate the pipe. Drag forces are usually given relative to the string weight measured with the string roating but not reciprocating. Measured from the roating string weight, the pick-up drag is usually slightly greater than the slack-off drag. The magnitudes of torque and drag are related in any particular well; high drag forced and exessive torque loads normally occur together. There are a number of phenomena wich contribute to torque and drag. Included are tight hole conditions, sloughing hole, keyseats, differential sticking, cuttings build up due to poor hole cleaning and sliding wellbore friction. With the exception of sliding friction, these causes are associated with problem conditions in the wellbore. Conversely, in wells with good hole conditions, the primary source of torque and drag is sliding friction. This paper is only concerned with the torque and drag caused by sliding friction. The cabability to predict frictional loads on drill pipe has two main benefits. First, more complete knowledge of drill-string loading allows use of improved drill-string design techniques. Drill-string components can be chosen using a systematic approach considering the force involved. Second, deep, highly-deviated wells can be planned to minimize torque and drag. Use of torque and drag as a criteria to select the most appropriate well path will help ensure successful drilling operations to total depth. 1 fig., 2 tabs. (Author).

  11. The tension as perturbative parameter in string theory

    International Nuclear Information System (INIS)

    Gamboa, J.

    1990-01-01

    We propose an approach to string theory where the zero theory is the null string. We find an explicit form of the propagator for the null string in the momentum space. We show that considering the tension as perturbative parameter, the perturbative series is completely summable and we find the propagator of the bosonic open string with tension T. (author) [pt

  12. Pre-geometrical field theory of the open string

    International Nuclear Information System (INIS)

    Nojiri, M.M.; Nojiri, Shin'ichi

    1988-01-01

    We propose a gauge invariant, background independent string action, which contains open and closed string fields and no kinetic terms. The kinetic term is generated through the condensation of the string fields, which is the solution of the equations of motion. We solve the equations and show that the action is classically equivalent to the open string action proposed by Hata et al. (orig.)

  13. Interactions between $U(1)$ Cosmic Strings: An Analytical Study

    OpenAIRE

    Bettencourt, L. M. A.; Rivers, R. J.

    1994-01-01

    We derive analytic expressions for the interaction energy between two general $U(1)$ cosmic strings as the function of their relative orientation and the ratio of the coupling constants in the model. The results are relevant to the statistic description of strings away from critical coupling and shed some light on the mechanisms involved in string formation and the evolution of string networks.

  14. L-cysteine reversibly inhibits glucose-induced biphasic insulin secretion and ATP production by inactivating PKM2.

    Science.gov (United States)

    Nakatsu, Daiki; Horiuchi, Yuta; Kano, Fumi; Noguchi, Yoshiyuki; Sugawara, Taichi; Takamoto, Iseki; Kubota, Naoto; Kadowaki, Takashi; Murata, Masayuki

    2015-03-10

    Increase in the concentration of plasma L-cysteine is closely associated with defective insulin secretion from pancreatic β-cells, which results in type 2 diabetes (T2D). In this study, we investigated the effects of prolonged L-cysteine treatment on glucose-stimulated insulin secretion (GSIS) from mouse insulinoma 6 (MIN6) cells and from mouse pancreatic islets, and found that the treatment reversibly inhibited glucose-induced ATP production and resulting GSIS without affecting proinsulin and insulin synthesis. Comprehensive metabolic analyses using capillary electrophoresis time-of-flight mass spectrometry showed that prolonged L-cysteine treatment decreased the levels of pyruvate and its downstream metabolites. In addition, methyl pyruvate, a membrane-permeable form of pyruvate, rescued L-cysteine-induced inhibition of GSIS. Based on these results, we found that both in vitro and in MIN6 cells, L-cysteine specifically inhibited the activity of pyruvate kinase muscle isoform 2 (PKM2), an isoform of pyruvate kinases that catalyze the conversion of phosphoenolpyruvate to pyruvate. L-cysteine also induced PKM2 subunit dissociation (tetramers to dimers/monomers) in cells, which resulted in impaired glucose-induced ATP production for GSIS. DASA-10 (NCGC00181061, a substituted N,N'-diarylsulfonamide), a specific activator for PKM2, restored the tetramer formation and the activity of PKM2, glucose-induced ATP production, and biphasic insulin secretion in L-cysteine-treated cells. Collectively, our results demonstrate that impaired insulin secretion due to exposure to L-cysteine resulted from its direct binding and inactivation of PKM2 and suggest that PKM2 is a potential therapeutic target for T2D.

  15. The wave function behavior of the open topological string partition function on the conifold

    International Nuclear Information System (INIS)

    Kashani-Poor, Amir-Kian

    2007-01-01

    We calculate the topological string partition function to all genus on the conifold, in the presence of branes. We demonstrate that the partition functions for different brane backgrounds (smoothly connected along a quantum corrected moduli space) can be interpreted as the same wave function in different polarizations. This behavior has a natural interpretation in the Chern-Simons target space description of the topological theory. Our detailed analysis however indicates that non-perturbatively, a modification of real Chern-Simons theory is required to capture the correct target space theory of the topological string. We perform our calculations in the framework of a free fermion representation of the open topological string, demonstrating that this framework extends beyond the simple C 3 geometry. The notion of a fermionic brane creation operator arises in this setting, and we study to what extent the wave function properties of the partition function can be extended to this operator

  16. A non-perturbative approach to strings

    International Nuclear Information System (INIS)

    Orland, P.

    1986-03-01

    After briefly reviewing the theory of strings in the light-cone gauge, a lattice regularized path integral for the amplitudes is discussed. The emphasis is put on a toy string model; the U(N) Veneziano model in the limit as N->infinite with g 0 2 N fixed. The lattice methods of Giles and Thorn are used extensively, but are found to require modification beyond perturbation theory. The twenty-six-dimensional toy string model is recast as a two-dimensional spin system. (orig.)

  17. Hermiticity and CPT in string theory

    International Nuclear Information System (INIS)

    Sonoda, Hidenori

    1989-01-01

    In the application of conformal field theory to string theory S-matrix elements are obtained from correlation functions of vertex operators. By studying the relation between the vertex operators for the incoming states and those for the outgoing states we obtain two results: First we show that hermiticity of the string vertices is equivalent to the CPT invariance of the corresponding conformal field theory. Secondly we prove that the S-matrix elements in any string theory in flat space-time background are invariant under CPT. (orig.)

  18. Open string decoupling and tachyon condensation

    International Nuclear Information System (INIS)

    Chalmers, G.

    2001-01-01

    The amplitudes in perturbative open string theory are examined as functions of the tachyon condensate parameter. The boundary state formalism demonstrates the decoupling of the open string modes at the non-perturbative minima of the tachyon potential via a degeneration of open world-sheets and identifies an independence of the coupling constants g s and g YM at general values of the tachyon condensate. The closed sector is generated at the quantum level; it is also generated at the classical level through the condensation of the propagating open string modes on the D-brane degrees of freedom.

  19. Notes on strings and higher spins

    International Nuclear Information System (INIS)

    Sagnotti, A

    2013-01-01

    This review is devoted to the intriguing and still largely unexplored links between string theory and higher spins, the types of excitations that lie behind their most cherished properties. A closer look at higher spin fields provides some further clues that string theory describes a broken phase of a higher spin gauge theory. Conversely, string amplitudes contain a wealth of information on higher spin interactions that can clarify long-standing issues related to their infrared behavior. This article is part of a special issue of Journal of Physics A: Mathematical and Theoretical devoted to ‘Higher spin theories and holography’. (review)

  20. A non-perturbative approach to strings

    International Nuclear Information System (INIS)

    Orland, P.

    1986-01-01

    After briefly reviewing the theory of strings in the light-cone gauge, a lattice regularized path integral for the amplitudes is discussed. The emphasis is put on a toy string model; the U(N) Veneziano model in the limit as N → ∞, with g/sup 2//sub o/N fixed. The lattice methods of Giles and Thorn are used extensively, but are found to require modification beyond perturbation theory. The twenty-six-dimensional toy string model is recast as a two-dimensional spin system