WorldWideScience

Sample records for target situation analysis

  1. METHODOLOGICAL ELEMENTS OF SITUATIONAL ANALYSIS

    Directory of Open Access Journals (Sweden)

    Tetyana KOVALCHUK

    2016-07-01

    Full Text Available The article deals with the investigation of theoretical and methodological principles of situational analysis. The necessity of situational analysis is proved in modern conditions. The notion “situational analysis” is determined. We have concluded that situational analysis is a continuous system study which purpose is to identify dangerous situation signs, to evaluate comprehensively such signs influenced by a system of objective and subjective factors, to search for motivated targeted actions used to eliminate adverse effects of the exposure of the system to the situation now and in the future and to develop the managerial actions needed to bring the system back to norm. It is developed a methodological approach to the situational analysis, its goal is substantiated, proved the expediency of diagnostic, evaluative and searching functions in the process of situational analysis. The basic methodological elements of the situational analysis are grounded. The substantiation of the principal methodological elements of system analysis will enable the analyst to develop adaptive methods able to take into account the peculiar features of a unique object which is a situation that has emerged in a complex system, to diagnose such situation and subject it to system and in-depth analysis, to identify risks opportunities, to make timely management decisions as required by a particular period.

  2. Adaptive Waveform Design for Cognitive Radar in Multiple Targets Situations

    Directory of Open Access Journals (Sweden)

    Xiaowen Zhang

    2018-02-01

    Full Text Available In this paper, the problem of cognitive radar (CR waveform optimization design for target detection and estimation in multiple extended targets situations is investigated. This problem is analyzed in signal-dependent interference, as well as additive channel noise for extended targets with unknown target impulse response (TIR. To address this problem, an improved algorithm is employed for target detection by maximizing the detection probability of the received echo on the promise of ensuring the TIR estimation precision. In this algorithm, an additional weight vector is introduced to achieve a trade-off among different targets. Both the estimate of TIR and transmit waveform can be updated at each step based on the previous step. Under the same constraint on waveform energy and bandwidth, the information theoretical approach is also considered. In addition, the relationship between the waveforms that are designed based on the two criteria is discussed. Unlike most existing works that only consider single target with temporally correlated characteristics, waveform design for multiple extended targets is considered in this method. Simulation results demonstrate that compared with linear frequency modulated (LFM signal, waveforms designed based on maximum detection probability and maximum mutual information (MI criteria can make radar echoes contain more multiple-target information and improve radar performance as a result.

  3. Computer-aided target tracking in motion analysis studies

    Science.gov (United States)

    Burdick, Dominic C.; Marcuse, M. L.; Mislan, J. D.

    1990-08-01

    Motion analysis studies require the precise tracking of reference objects in sequential scenes. In a typical situation, events of interest are captured at high frame rates using special cameras, and selected objects or targets are tracked on a frame by frame basis to provide necessary data for motion reconstruction. Tracking is usually done using manual methods which are slow and prone to error. A computer based image analysis system has been developed that performs tracking automatically. The objective of this work was to eliminate the bottleneck due to manual methods in high volume tracking applications such as the analysis of crash test films for the automotive industry. The system has proven to be successful in tracking standard fiducial targets and other objects in crash test scenes. Over 95 percent of target positions which could be located using manual methods can be tracked by the system, with a significant improvement in throughput over manual methods. Future work will focus on the tracking of clusters of targets and on tracking deformable objects such as airbags.

  4. Situational Analysis and Engineering Work Practices

    DEFF Research Database (Denmark)

    Buch, Anders; Andersen, Vibeke

    2013-01-01

    boundaries in order to investigate the dynamics of cultural reproduction in expert work practices. The paper will propose a new research agenda that – inspired by George Marcus’ multi-sited ethnographic methodology (Marcus 1998) and Adele Clarke’s situational analysis (Clarke 2005) – analyze (and contrasts...... of analysis and allowing the situation to be scalable. Likewise, it aspires to overcome the widespread dualism of ‘text’ and ‘con-text’ that pervades contemporary social science methods. We will argue that expert work practices – although reproduced and enacted in local settings – are also enactments......Studies of work practices of scientists and engineers inspired by Science and Technology Studies (STS) provide new material for a richer understanding of expert cultures and expert work practices. However, the specific and strictly situated focus of many of these studies threatens to limit...

  5. Learning Situations in Nursing Education: A Concept Analysis.

    Science.gov (United States)

    Shahsavari, Hooman; Zare, Zahra; Parsa-Yekta, Zohreh; Griffiths, Pauline; Vaismoradi, Mojtaba

    2018-02-01

    The nursing student requires opportunities to learn within authentic contexts so as to enable safe and competent practice. One strategy to facilitate such learning is the creation of learning situations. A lack of studies on the learning situation in nursing and other health care fields has resulted in insufficient knowledge of the characteristics of the learning situation, its antecedents, and consequences. Nurse educators need to have comprehensive and practical knowledge of the definition and characteristics of the learning situation so as to enable their students to achieve enhanced learning outcomes. The aim of this study was to clarify the concept of the learning situation as it relates to the education of nurses and improve understanding of its characteristics, antecedents, and consequences. The Bonis method of concept analysis, as derived from the Rodgers' evolutionary method, provided the framework for analysis. Data collection and analysis were undertaken in two phases: "interdisciplinary" and "intra-disciplinary." The data source was a search of the literature, encompassing nursing and allied health care professions, published from 1975 to 2016. No agreement on the conceptual phenomenon was discovered in the international literature. The concept of a learning situation was used generally in two ways and thus classified into the themes of: "formal/informal learning situation" and "biologic/nonbiologic learning situation." Antecedents to the creation of a learning situation included personal and environmental factors. The characteristics of a learning situation were described in terms of being complex, dynamic, and offering potential and effective learning opportunities. Consequences of the learning situation included enhancement of the students' learning, professionalization, and socialization into the professional role. The nurse educator, when considering the application of the concept of a learning situation in their educational planning, must

  6. Situational Analysis of Engineering Practice

    DEFF Research Database (Denmark)

    Buch, Anders

    STS inspired studies of engineering work practices provide new material for a richer understanding of engineering culture. However, the specific and strictly situated focus of many of these studies threatens to limit discussions of engineering practices to departmental and discrete institutional...... settings. This micro perspective potentially overlooks the inherent and overarching normativities that inform engineering culture. Furthermore, the micro perspective has difficulties in transgressing institutional boundaries in order to investigate the dynamics of cultural reproduction in engineering....... The paper will propose a research agenda that – inspired by George Marcus’ multi-sited ethnographic methodology (Marcus 1998) and Adele Clarke’s situational analysis (Clarke 2005) – analyze (and contrasts) engineering practices in diverse settings (e.g. engineering education and engineering work) in order...

  7. Fundamental situations in teaching biology: The case of parthenogenesis

    Directory of Open Access Journals (Sweden)

    Robert Evans

    2012-06-01

    Full Text Available This theoretical paper considers the notion of fundamental situation in the sense of Brousseau’s theory of didactical situations. It introduces some precise elements of this theory in which a teacher provides an environment for student work that aims to enable students, through constructive inquiry, to acquire well defined pieces of scientific knowledge. Situations become fundamental if they not only allow, but force students to construct the target knowledge. A classical example from mathematics is presented, where the target knowledge is a theorem of plane geometry presented as a puzzle. Then a new fundamental situation in biology is described for parthenogenetic reproduction, which has recently turned out to occur in Komodo dragons. An explicit demand to generate and test hypotheses that could explain the given example of dragon reproduction, using authentic DNA data, is given to students. The paper concludes with an analysis of the extent to which this fundamental situation in biology is authentic to the theory of didactical situations.

  8. Hot-spot analysis for drug discovery targeting protein-protein interactions.

    Science.gov (United States)

    Rosell, Mireia; Fernández-Recio, Juan

    2018-04-01

    Protein-protein interactions are important for biological processes and pathological situations, and are attractive targets for drug discovery. However, rational drug design targeting protein-protein interactions is still highly challenging. Hot-spot residues are seen as the best option to target such interactions, but their identification requires detailed structural and energetic characterization, which is only available for a tiny fraction of protein interactions. Areas covered: In this review, the authors cover a variety of computational methods that have been reported for the energetic analysis of protein-protein interfaces in search of hot-spots, and the structural modeling of protein-protein complexes by docking. This can help to rationalize the discovery of small-molecule inhibitors of protein-protein interfaces of therapeutic interest. Computational analysis and docking can help to locate the interface, molecular dynamics can be used to find suitable cavities, and hot-spot predictions can focus the search for inhibitors of protein-protein interactions. Expert opinion: A major difficulty for applying rational drug design methods to protein-protein interactions is that in the majority of cases the complex structure is not available. Fortunately, computational docking can complement experimental data. An interesting aspect to explore in the future is the integration of these strategies for targeting PPIs with large-scale mutational analysis.

  9. HIV/AIDS situational analysis among tertiary institutions in the ...

    African Journals Online (AJOL)

    The situational analysis was organised into sections dealing with SWOT analysis, risk analysis, management strategies, prevention activities and partnerships. The SWOT and risk analyses showed some notable activities on how the institutions have responded to HIV/AIDS. The institutions had implemented HIV/AIDS ...

  10. Measuring situation awareness of operation teams in NPPs using a verbal protocol analysis

    International Nuclear Information System (INIS)

    Lee, Seung Woo; Park, Jinkyun; Kim, Ar ryum; Seong, Poong Hyun

    2012-01-01

    Highlights: ► A method for measuring team situation awareness is developed. ► Verbal protocol analysis is adopted in this method. ► This method resolves uncertainties from conventional methods. ► This method can be used in evaluating the human–system interfaces. - Abstract: Situation awareness (SA) continues to receive a considerable amount of attention from the ergonomics community given that need for operators to maintain SA is frequently cited as a key to effective and efficient performance. Although complex and dynamic environments such as that of a main control room (MCR) in a nuclear power plant (NPP) are operated by operation teams, and while team situation awareness (TSA) is also cited as an important factor, research is limited to individual SA. However, understanding TSA can provide a window onto the characteristics of team acquisition as well as the performance of a complex skill. Therefore, such knowledge can be valuable in diagnosing team performance successes and failures. Moreover, training and design interventions can target the cognitive underpinnings of team performance, with implications for the design of technological aids to improve team performance. Despite these advantages and the importance of understanding TSA, measures and methods targeting TSA are sparse and fail to address it properly. In this study, an objective TSA measurement method is developed in an effort to understand TSA. First, key considerations for developing a method are derived. Based on these considerations, the proposed method is developed while mainly focusing on the creation of logical connections between team communications and TSA. A speech act coding scheme is also implemented to analyze team communications. The TSA measurement method developed in this study provides a measure for each level of TSA. It was revealed from a preliminary study that this TSA measurement method is feasible for measuring TSA to a fair extent. Useful insight into TSA is also derived.

  11. Situation Analysis of Healthcare Service Delivery using ...

    African Journals Online (AJOL)

    ISML5

    7. No. 1, AARSE 2017 Special Edition, January 2017. 75. Situation Analysis of ... then becomes a major bottleneck to proper planning and policy formulation in healthcare delivery. ... Uganda Annual Health Sector Performance Report for Financial Year 2014/15 ... government's strategy of taking services closer to the people.

  12. Digital map and situation surface: a team-oriented multidisplay workspace for network enabled situation analysis

    Science.gov (United States)

    Peinsipp-Byma, E.; Geisler, Jürgen; Bader, Thomas

    2009-05-01

    System concepts for network enabled image-based ISR (intelligence, surveillance, reconnaissance) is the major mission of Fraunhofer IITB's applied research in the area of defence and security solutions. For the TechDemo08 as part of the NATO CNAD POW Defence against terrorism Fraunhofer IITB advanced a new multi display concept to handle the shear amount and high complexity of ISR data acquired by networked, distributed surveillance systems with the objective to support the generation of a common situation picture. Amount and Complexity of ISR data demands an innovative man-machine interface concept for humans to deal with it. The IITB's concept is the Digital Map & Situation Surface. This concept offers to the user a coherent multi display environment combining a horizontal surface for the situation overview from the bird's eye view, an attached vertical display for collateral information and so-called foveatablets as personalized magic lenses in order to obtain high resolved and role-specific information about a focused areaof- interest and to interact with it. In the context of TechDemo08 the Digital Map & Situation Surface served as workspace for team-based situation visualization and analysis. Multiple sea- and landside surveillance components were connected to the system.

  13. Threat evaluation for impact assessment in situation analysis systems

    Science.gov (United States)

    Roy, Jean; Paradis, Stephane; Allouche, Mohamad

    2002-07-01

    Situation analysis is defined as a process, the examination of a situation, its elements, and their relations, to provide and maintain a product, i.e., a state of situation awareness, for the decision maker. Data fusion is a key enabler to meeting the demanding requirements of military situation analysis support systems. According to the data fusion model maintained by the Joint Directors of Laboratories' Data Fusion Group, impact assessment estimates the effects on situations of planned or estimated/predicted actions by the participants, including interactions between action plans of multiple players. In this framework, the appraisal of actual or potential threats is a necessary capability for impact assessment. This paper reviews and discusses in details the fundamental concepts of threat analysis. In particular, threat analysis generally attempts to compute some threat value, for the individual tracks, that estimates the degree of severity with which engagement events will potentially occur. Presenting relevant tracks to the decision maker in some threat list, sorted from the most threatening to the least, is clearly in-line with the cognitive demands associated with threat evaluation. A key parameter in many threat value evaluation techniques is the Closest Point of Approach (CPA). Along this line of thought, threatening tracks are often prioritized based upon which ones will reach their CPA first. Hence, the Time-to-CPA (TCPA), i.e., the time it will take for a track to reach its CPA, is also a key factor. Unfortunately, a typical assumption for the computation of the CPA/TCPA parameters is that the track velocity will remain constant. When a track is maneuvering, the CPA/TCPA values will change accordingly. These changes will in turn impact the threat value computations and, ultimately, the resulting threat list. This is clearly undesirable from a command decision-making perspective. In this regard, the paper briefly discusses threat value stabilization

  14. Strengthening rehabilitation services in Indonesia: A brief situation analysis.

    Science.gov (United States)

    Nugraha, Boya; Setyono, Garry Rahardian; Defi, Irma Ruslina; Gutenbrunner, Christoph

    2018-04-18

    People with disability (PWD) in Indonesia are often neglected by society. Improving their life situation towards full participation in society is crucial. As a health strategy, rehabilitation can improve func-tioning, quality of life and participation in society. However, rehabilitation services in Indonesia need improvement. Making a situation analysis of rehabilitation services and their provision in the country is a pre-requisite to taking any action towards improvement. This paper compiles available data related to disability and rehabilitation services in Indonesia, using the Rehabilitation Services Assessment Tool (RSAT) as a framework. Gaps in provision were analysed, resulting in the compilation of a list of generic recommendations to improve rehabilitation services in the country. Indonesia faces many challenges in rehabilitation services, including the health workforce and the provision of services. This situation analysis and list of generic recommendations may be used in further discussions with relevant stakeholders in the country to develop a national strategy to strengthen rehabilitation services.

  15. Implementation synergies that exploit situational knowledge strategically

    DEFF Research Database (Denmark)

    Quitzau, Maj-Britt; Petersen, Jens-Phillip

    This paper illustrates how strategic and situated forms of knowledge may increase capacity to implement energy strategies in local urban development projects. Through analysis of front runner implementation projects, we show that the involved planners utilize situational learning processes...... strategically to develop more viable implementation trajectories. These findings resonate well with relational and network orienteered research in contemporary planning theory. In the selected case studies, we can see that planners deliberately seek to extend traditional planning approaches, like e.......g. regulation, with broader context‐specific learning processes. In doing so, we argue that – what we call – an implementation synergy is established by interlacing different forms of situational knowledge with strategic knowledge about how to reach a desired energy target. In conclusion, the paper identifies...

  16. Situational analysis of conflict interaction of employees belonging to generations X and Y

    Directory of Open Access Journals (Sweden)

    Pishchik V.I.

    2018-03-01

    Full Text Available The article described the situational approach to the analysis of conflicts between representatives of different generations, and analyzed intergenerational conflict, psychological portraits of members of generations X and Y. The study surveyed 144 people. Applied techniques: test Thomas, methods of identifying conflicts of expectations S.I. Erina, E.P. Sharapova; methods of identifying potential interpersonal conflicts A.N. Lebedeva, I.I. Level; developed a questionnaire analysis of the conflict, as well as using situation analysis (related to various situations of the conflict of different generations, their evaluation and analysis. The studies confirmed the differences in perceptions and attitudes to conflict situations of different generations. According to the obtained results we were able to identify a number of patterns, relations, and describe the attitude of employees of different generations to emerging or potential conflicts.

  17. Child malnutrition and mortality in Swaziland: Situation analysis of ...

    African Journals Online (AJOL)

    Child malnutrition and mortality in Swaziland: Situation analysis of the immediate, ... African Journal of Food, Agriculture, Nutrition and Development ... care of children and women, insufficient health services and unhealthy environment), and ...

  18. A situational approach to the measurement of safety culture

    International Nuclear Information System (INIS)

    Semmer, N.; Regennass, A.

    1997-01-01

    Values and social norms are the main target of most approaches to the study of safety culture and many existing survey methodologies directly ask for these norms and values. However, a number of considerations point to the dangers of limiting the evaluation of safety culture to the analysis of these responses. Therefore the necessity is stressed to also consider how actual situations activate norms and behaviours. This relates to the fact that in any given situation both aspects of the appraisal of reality are present: the objective definition of the situation and its personal evaluation. The latter not only reflects the ''official'' norms and values but also ''basic underlying assumptions''. The situational approach introduced in this paper confronts people with situations which contain a dilemma with conflicting social norms and where various costs and benefits are associated with different types of behaviour. In addition, the prerequisites and limitations of the situational approach are discussed. (author). 9 refs, 1 fig

  19. GUIDELINES FOR TRAINING SITUATION ANALYSIS (TSA). FINAL REPORT.

    Science.gov (United States)

    CHENZOFF, ANDREW P.; FOLLEY, JOHN D., JR.

    THESE GUIDELINES REPRESENT A TEXTBOOK FOR INSTRUCTION IN THREE PHASES OF TRAINING SITUATION ANALYSIS (TSA), A STANDARDIZED PROCEDURE DEVELOPED BY THE NAVAL TRAINING DEVICE CENTER FOR SYSTEMATICALLY GATHERING AND INTERPRETING THE INFORMATION RELEVANT TO THE PLANNING OF TRAINING AND TRAINING DEVICES. THREE PHASES OF TSA ARE DESCRIBED IN…

  20. Nuclear right and South Market Common : health citizen protection and environment: comparative study Mercosur situation:critical analysis Uruguay situation

    International Nuclear Information System (INIS)

    Puig, D

    1998-01-01

    The present work presents to general study on: the applications of nuclear techniques, technical fundamental for stablishment of to program of radiation protection, to comparative study legislation in radiation protection in the South Market Common (MERCOSUR)Argentina,Brazil,Paraguay,Uruguay as well as Treaties and Agreements. The author carries out a critical analysis from the situation to Institutional level in the Uruguay and it outlines some alternatives to improve the situation [es

  1. Analysis of application for situational teaching method in tourism English teaching

    Directory of Open Access Journals (Sweden)

    Li Jing

    2016-01-01

    Full Text Available Faced with China’s English teaching problems today, it is not enough to just know that the situational teaching method can be effectively applied in a wide range of English teaching, but there is a must to embody the specific application value of the situational teaching method. This paper first analyzes tourism English teaching in China through establishing the quantifiable group-index hierarchical structure model to obtain the optimal training program of China’s tourism English talents, and then carries out a detailed analysis of the application and role of the situational teaching method in training of the tourism English ability to obtain the specific application scope and application value of the situational teaching method in the tourism English teaching.

  2. Measuring situational avoidance in older drivers: An application of Rasch analysis.

    Science.gov (United States)

    Davis, Jessica; Conlon, Elizabeth; Ownsworth, Tamara; Morrissey, Shirley

    2016-02-01

    Situational avoidance is a form of driving self-regulation at the strategic level of driving behaviour. It has typically been defined as the purposeful avoidance of driving situations perceived as challenging or potentially hazardous. To date, assessment of the psychometric properties of existing scales that measure situational avoidance has been sparse. This study examined the contribution of Rasch analysis to the situational avoidance construct. Three hundred and ninety-nine Australian drivers (M=66.75, SD=10.14, range: 48-91 years) completed the Situational Avoidance Questionnaire (SAQ). Following removal of the item Parallel Parking, the scale conformed to a Rasch model, showing good person separation, sufficient reliability, little disordering of thresholds, and no evidence of differential item functioning by age or gender. The residuals were independent supporting the assumption of unidimensionality and in conforming to a Rasch model, SAQ items were found to be hierarchical or cumulative. Increased avoidance was associated with factors known to be related to driving self-regulation more broadly, including older age, female gender, reduced driving space and frequency, reporting a change in driving in the past five years and poorer indices of health (i.e., self-rated mood, vision and cognitive function). Overall, these results support the use of the SAQ as a psychometrically sound measure of situational avoidance. Application of Rasch analysis to this area of research advances understanding of the driving self-regulation construct and its practice by drivers in baby boomer and older adult generations. Copyright © 2015 Elsevier Ltd. All rights reserved.

  3. Cognitive Task Analysis Based Training for Cyber Situation Awareness

    OpenAIRE

    Huang , Zequn; Shen , Chien-Chung; Doshi , Sheetal; Thomas , Nimmi; Duong , Ha

    2015-01-01

    Part 1: Innovative Methods; International audience; Cyber attacks have been increasing significantly in both number and complexity, prompting the need for better training of cyber defense analysts. To conduct effective training for cyber situation awareness, it becomes essential to design realistic training scenarios. In this paper, we present a Cognitive Task Analysis based approach to address this training need. The technique of Cognitive Task Analysis is to capture and represent knowledge ...

  4. Decoupling, situated cognition and immersion in art.

    Science.gov (United States)

    Reboul, Anne

    2015-09-01

    Situated cognition seems incompatible with strong decoupling, where representations are deployed in the absence of their targets and are not oriented toward physical action. Yet, in art consumption, the epitome of a strongly decoupled cognitive process, the artwork is a physical part of the environment and partly controls the perception of its target by the audience, leading to immersion. Hence, art consumption combines strong decoupling with situated cognition.

  5. Integrated situational awareness for cyber attack detection, analysis, and mitigation

    Science.gov (United States)

    Cheng, Yi; Sagduyu, Yalin; Deng, Julia; Li, Jason; Liu, Peng

    2012-06-01

    Real-time cyberspace situational awareness is critical for securing and protecting today's enterprise networks from various cyber threats. When a security incident occurs, network administrators and security analysts need to know what exactly has happened in the network, why it happened, and what actions or countermeasures should be taken to quickly mitigate the potential impacts. In this paper, we propose an integrated cyberspace situational awareness system for efficient cyber attack detection, analysis and mitigation in large-scale enterprise networks. Essentially, a cyberspace common operational picture will be developed, which is a multi-layer graphical model and can efficiently capture and represent the statuses, relationships, and interdependencies of various entities and elements within and among different levels of a network. Once shared among authorized users, this cyberspace common operational picture can provide an integrated view of the logical, physical, and cyber domains, and a unique visualization of disparate data sets to support decision makers. In addition, advanced analyses, such as Bayesian Network analysis, will be explored to address the information uncertainty, dynamic and complex cyber attack detection, and optimal impact mitigation issues. All the developed technologies will be further integrated into an automatic software toolkit to achieve near real-time cyberspace situational awareness and impact mitigation in large-scale computer networks.

  6. A situational analysis of child and adolescent mental health services ...

    African Journals Online (AJOL)

    findings of a situational analysis of CA mental health policy and services in ... are part of a 5 year study, the Mental Health and Poverty Project, which aims to provide new knowledge regarding ..... children, they think its bad omen” (SSI, key.

  7. A Bayesian analysis of the mixed labelling phenomenon in two-target tracking

    NARCIS (Netherlands)

    Aoki, E.H.; Boers, Y.; Svensson, L.; Mandal, Pranab K.; Bagchi, Arunabha

    In mulit-target tracking and labelling (MTTL), mixed labelling corresponds to a situation where there is ambiguity in labelling, i.e. in the assignment of labels to locations (where a "location" here means simply an unlabelled single-target state. The phenomenon is well-known in literature, and

  8. Efficiency in the Worst Production Situation Using Data Envelopment Analysis

    Directory of Open Access Journals (Sweden)

    Md. Kamrul Hossain

    2013-01-01

    Full Text Available Data envelopment analysis (DEA measures relative efficiency among the decision making units (DMU without considering noise in data. The least efficient DMU indicates that it is in the worst situation. In this paper, we measure efficiency of individual DMU whenever it losses the maximum output, and the efficiency of other DMUs is measured in the observed situation. This efficiency is the minimum efficiency of a DMU. The concept of stochastic data envelopment analysis (SDEA is a DEA method which considers the noise in data which is proposed in this study. Using bounded Pareto distribution, we estimate the DEA efficiency from efficiency interval. Small value of shape parameter can estimate the efficiency more accurately using the Pareto distribution. Rank correlations were estimated between observed efficiencies and minimum efficiency as well as between observed and estimated efficiency. The correlations are indicating the effectiveness of this SDEA model.

  9. Void analysis of target residues at SPS energy -evidence of correlation with fractal behaviour

    International Nuclear Information System (INIS)

    Ghosh, Dipak; Deb, Argha; Das, Rupa . E-mail : dipakghosh_in@yahoo.com

    2007-01-01

    This paper presents an analysis of the target residues in 32 S -AgBr and 16 0 -AgBr interactions at 200 AGeV and 60AGeV respectively in terms of fractal moment by Takagi method and void probability scaling. The study reveals an interesting feature of the production process. In 16 O- AgBr interactions multifractal behaviour is present in both hemispheres and void probability does not show a scaling behaviour, but at high energy the situation changes. In 32 S -AgBr interactions for both hemisphere monofractal behaviour is indicated by that data and void probability also shows good scaling behaviour. This suggests that a possible correlation of void probability with fractal behaviour of target residues. (author)

  10. Situational Influences on Reactions to Observed Violence.

    Science.gov (United States)

    Berkowitz, Leonard

    1986-01-01

    Examines data on what situational factors influence people's desire to view violent television programming. Surveys research on the effects on viewer's behavior of the presence of other observers, the nature of the available target, situational features operating as retrieval cues, the viewers' interpretations of the violent scenes, and the…

  11. Distributed sensor management for space situational awareness via a negotiation game

    Science.gov (United States)

    Jia, Bin; Shen, Dan; Pham, Khanh; Blasch, Erik; Chen, Genshe

    2015-05-01

    Space situational awareness (SSA) is critical to many space missions serving weather analysis, communications, and navigation. However, the number of sensors used in space situational awareness is limited which hinders collision avoidance prediction, debris assessment, and efficient routing. Hence, it is critical to use such sensor resources efficiently. In addition, it is desired to develop the SSA sensor management algorithm in a distributed manner. In this paper, a distributed sensor management approach using the negotiation game (NG-DSM) is proposed for the SSA. Specifically, the proposed negotiation game is played by each sensor and its neighboring sensors. The bargaining strategies are developed for each sensor based on negotiating for accurately tracking desired targets (e.g., satellite, debris, etc.) . The proposed NG-DSM method is tested in a scenario which includes eight space objects and three different sensor modalities which include a space based optical sensor, a ground radar, or a ground Electro-Optic sensor. The geometric relation between the sensor, the Sun, and the space object is also considered. The simulation results demonstrate the effectiveness of the proposed NG-DSM sensor management methods, which facilitates an application of multiple-sensor multiple-target tracking for space situational awareness.

  12. Current situation of pests targeted by Bt crops in Latin America.

    Science.gov (United States)

    Blanco, C A; Chiaravalle, W; Dalla-Rizza, M; Farias, J R; García-Degano, M F; Gastaminza, G; Mota-Sánchez, D; Murúa, M G; Omoto, C; Pieralisi, B K; Rodríguez, J; Rodríguez-Maciel, J C; Terán-Santofimio, H; Terán-Vargas, A P; Valencia, S J; Willink, E

    2016-06-01

    Transgenic crops producing Bacillus thuringiensis- (Bt) insecticidal proteins (Bt crops) have provided useful pest management tools to growers for the past 20 years. Planting Bt crops has reduced the use of synthetic insecticides on cotton, maize and soybean fields in 11 countries throughout Latin America. One of the threats that could jeopardize the sustainability of Bt crops is the development of resistance by targeted pests. Governments of many countries require vigilance in measuring changes in Bt-susceptibility in order to proactively implement corrective measures before Bt-resistance is widespread, thus prolonging the usefulness of Bt crops. A pragmatic approach to obtain information on the effectiveness of Bt-crops is directly asking growers, crop consultants and academics about Bt-resistance problems in agricultural fields, first-hand information that not necessarily relies on susceptibility screens performed in laboratories. This type of information is presented in this report. Problematic pests of cotton and soybeans in five Latin American countries currently are effectively controlled by Bt crops. Growers that plant conventional (non-Bt) cotton or soybeans have to spray synthetic insecticides against multiple pests that otherwise are controlled by these Bt crops. A similar situation has been observed in six Latin American countries where Bt maize is planted. No synthetic insecticide applications are used to control corn pests because they are controlled by Bt maize, with the exception of Spodoptera frugiperda. While this insect in some countries is still effectively controlled by Bt maize, in others resistance has evolved and necessitates supplemental insecticide applications and/or the use of Bt maize cultivars that express multiple Bt proteins. Partial control of S. frugiperda in certain countries is due to its natural tolerance to the Bt bacterium. Of the 31 pests targeted and controlled by Bt crops in Latin America, only S. frugiperda has shown

  13. Individual differences in anxiety responses to stressful situations : A three-mode component analysis model

    NARCIS (Netherlands)

    Van Mechelen, Iven; Kiers, Henk A.L.

    1999-01-01

    The three-mode component analysis model is discussed as a tool for a contextualized study of personality. When applied to person x situation x response data, the model includes sets of latent dimensions for persons, situations, and responses as well as a so-called core array, which may be considered

  14. Injury situations in Freestyle Ski Cross (SX): a video analysis of 33 cases.

    Science.gov (United States)

    Randjelovic, Stefan; Heir, Stig; Nordsletten, Lars; Bere, Tone; Bahr, Roald

    2014-01-01

    Although injury risk in Freestyle Ski Cross (SX) is high, little is known about the situations leading up to time-loss injuries. To describe the situations leading up to time-loss injuries in elite Freestyle SX. Descriptive video analysis. Thirty-three video recordings of SX injuries reported through the International Ski Federation Injury Surveillance System for four World Cup seasons (2006/2007 through 2010) were obtained. Five experts in the fields of sport medicine and SX analysed each case to describe in detail the situation leading up to the injury (skiing situation and skier behaviour). Injuries occurred in four different skiing situations: jumping (n=16), turning (n=8), jumping and turning (n=7) and rollers (n=2). All injured skiers lost control before time of injury (n=33), due to skier-opponent contact (n=13), technical errors (n=8) or inappropriate strategy (n=8), which led to a fall (n=29). Contact occurred in 21 of 33 cases, usually unintentional at landing or take-off, caused by the opponent (n=11) or injured skier (n=8). The technical error cases (n=8) were dominated by bad jumping technique (n=6) and too much inside lean in turning situations (n=2), while inappropriate course line and bad timing at take off (n=7) dominated the inappropriate strategy cases (n=8). We identified four main injury situations in elite SX, dominated by jumping situations. The primary cause of injury was unintentional skier-opponent contact in jumping, bank turning and roller situations. Another common cause of injury was personal errors (inappropriate technique and strategy) at take-off and in turning situations.

  15. Assessing Operational Situations

    DEFF Research Database (Denmark)

    Zhang, Xinxin

    In spite of the high level of automation commonly applied to today’s engineering system, humans’ skill and knowledge still plays a central role in the systems’ daily operation, critical decision making, and accident management. The complexity of the engineered system poses great challenge for human...... operators to perceive and understand the operational situation. The research domain of situation awareness approaches the operational challenges from the human cognition perspective while the presented thesis aims at supporting situation assessment from the system perspective. The thesis has reviewed...... different perspectives on situation awareness in the human factor studies and uses the knowledge reflectively for system representation and analysis. The human cognitive activities during complex plant operation and how they perceive a situation and what kind of knowledge has to be established in the human...

  16. Educational interventions targeted at minors in situations of grave social vulnerability and their families

    Science.gov (United States)

    de La Caba Collado, Mariangeles; Bartau Rojas, Isabel

    2010-10-01

    The aim of this article is to outline and assess an educational intervention programme targeted at improving the skills of families and the personal and social development of children living in situations of grave social vulnerability. The sample comprised 10 families during the first phase of the intervention and six during the second. The design, intervention and assessment process of this study was carried out in two phases over a period of a year and a half. For both phases, three different groups—of men/fathers, women/mothers and children—were established. Study variables (parenting skills and children's personal and social development) were evaluated before and after the intervention in every group, as well as during the entire process. The results, taking into account the improvements reported by all the participants (social workers, group monitors, fathers, mothers, children) show that inter-professional involvement and coordination at all phases of the intervention is vital in order to achieve small but significant improvements.

  17. Antibiotic use and resistance in emerging economies: a situation analysis for Viet Nam.

    Science.gov (United States)

    Nguyen, Kinh Van; Thi Do, Nga Thuy; Chandna, Arjun; Nguyen, Trung Vu; Pham, Ca Van; Doan, Phuong Mai; Nguyen, An Quoc; Thi Nguyen, Chuc Kim; Larsson, Mattias; Escalante, Socorro; Olowokure, Babatunde; Laxminarayan, Ramanan; Gelband, Hellen; Horby, Peter; Thi Ngo, Ha Bich; Hoang, Mai Thanh; Farrar, Jeremy; Hien, Tran Tinh; Wertheim, Heiman F L

    2013-12-10

    Antimicrobial resistance is a major contemporary public health threat. Strategies to contain antimicrobial resistance have been comprehensively set forth, however in developing countries where the need for effective antimicrobials is greatest implementation has proved problematic. A better understanding of patterns and determinants of antibiotic use and resistance in emerging economies may permit more appropriately targeted interventions.Viet Nam, with a large population, high burden of infectious disease and relatively unrestricted access to medication, is an excellent case study of the difficulties faced by emerging economies in controlling antimicrobial resistance. Our working group conducted a situation analysis of the current patterns and determinants of antibiotic use and resistance in Viet Nam. International publications and local reports published between 1-1-1990 and 31-8-2012 were reviewed. All stakeholders analyzed the findings at a policy workshop and feasible recommendations were suggested to improve antibiotic use in Viet Nam.Here we report the results of our situation analysis focusing on: the healthcare system, drug regulation and supply; antibiotic resistance and infection control; and agricultural antibiotic use. Market reforms have improved healthcare access in Viet Nam and contributed to better health outcomes. However, increased accessibility has been accompanied by injudicious antibiotic use in hospitals and the community, with predictable escalation in bacterial resistance. Prescribing practices are poor and self-medication is common - often being the most affordable way to access healthcare. Many policies exist to regulate antibiotic use but enforcement is insufficient or lacking.Pneumococcal penicillin-resistance rates are the highest in Asia and carbapenem-resistant bacteria (notably NDM-1) have recently emerged. Hospital acquired infections, predominantly with multi-drug resistant Gram-negative organisms, place additional strain on

  18. Work Analysis of the nuclear power plant control room operators (II): The classes of situation

    International Nuclear Information System (INIS)

    Alengry, P.

    1989-03-01

    This report presents a work analysis of nuclear power plant control room operators focused on the classes of situation they can meet during their job. Each class of situation is first described in terms of the process variables states. We then describe the goals of the operators and the variables they process in each class of situation. We report some of the most representative difficulties encountered by the operators in each class of situation. Finally, we conclude on different topics: the nature of the mental representations, the temporal dimension, the monitoring activity, and the role of the context in the work of controlling a nuclear power plant [fr

  19. Modeling of Future Initial Teacher of Foreign Language Training, Using Situation Analysis

    Directory of Open Access Journals (Sweden)

    Maryana М. Sidun

    2012-12-01

    Full Text Available The article discloses the content of modeling of future initial teacher of foreign language, using situation analysis, defines the stages of modeling during the professional competence formation of future teacher of foreign language: preparatory, analytical and executive.

  20. The Situation Analysis Study of the family planning program in Kenya.

    Science.gov (United States)

    Miller, R A; Ndhlovu, L; Gachara, M M; Fisher, A A

    1991-01-01

    A new, relatively "quick and clean" operations research approach called a "situation analysis" was developed for examining the strengths and weaknesses of the family planning program of Kenya. Field research teams visited a stratified random sample of 99 of the Ministry of Health's approximately 775 service delivery points. Observation techniques and interviewing were used to collect information on program components and on the quality of care provided to new family planning clients during the observation day. As late as 1986, the Kenya program was rated "weak" and "poor" in the international literature. The Kenya Situation Analysis Study found a functioning, integrated maternal and child health/family planning program serving large numbers of clients, with an emphasis on oral contraceptives and Depo-Provera (and an underemphasis on permanent methods). Although a number of program problems were revealed by the study, overall, in terms of performance, a rating of "moderate" is suggested as more appropriate for Kenya's national family planning program today. In terms of the quality of care, a "moderate to moderate-high" rating is suggested.

  1. Comparative social-technical analysis of arrangements for the reduction of energy poverty situations, and development of targeted intervention strategies. Final report

    International Nuclear Information System (INIS)

    Beslay, Christophe; Gournet, Romain; Zelem, Marie-Christine; Vidal, Marion; Huze, Marie-Helene; Cyssau, Rene; Ducrocq, Vincent; Menard, Francois; Cherel, Didier

    2010-03-01

    This study aimed at comparing different existing arrangements which have been implemented to reduce energy poverty. This comparison is based on an analysis of their actor configurations, and on their influence on the elaboration of implemented actions. It aimed at determining to which extent strategies and abilities could be complemented or are limited, and at identifying conditions of efficiency for implemented actions. This analysis also took four important issues into account: financial resources, housing energetic status and equipment, practices and representations of comfort and of energy, and arrangements for the struggle against energy poverty. Five arrangements, actions or programs have been compared: three implemented in three different French districts (Haute-Savoie, Gers and Tarn), one implemented in the Quebec province in Canada, and one implemented in the French Guyana. The comparison is made in terms of definitions and perceptions of energy poverty, of arrangement implementation, of household reception mode, of complexity of energy poverty situations, and of results of technical visits to households. The second part of the report makes some recommendations and proposals for the creation of a local intervention service for energy management

  2. Learning game for training child bicyclists' situation awareness.

    Science.gov (United States)

    Lehtonen, Esko; Sahlberg, Heidi; Rovamo, Emilia; Summala, Heikki

    2017-08-01

    Encouraging more children to bicycle would produce both environmental and health benefits, but bicycling accidents are a major source of injuries and fatalities among children. One reason for this may be children's less developed hazard perception skills. We assume that children's situation awareness could be trained with a computer based learning game, which should also improve their hazard perception skills. In this paper, we present a prototype for such a game and pilot it with 8-9year old children. The game consisted of videos filmed from a bicyclist's perspective. Using a touchscreen, the player's task was to point out targets early enough to gain points. The targets were either overt (other visible road users on a potentially conflicting course) or covert (occlusions, i.e. locations where other road users could suddenly emerge). If a target was missed or identified too late, the video was paused and feedback was given. The game was tested with 49 children from the 2nd grade of primary school (aged 8-9). 31 young adults (aged 22-34) played the game for comparison. The effect of the game on situation awareness was assessed with situation awareness tests in a crossover design. Similar videos were used in the tests as in the game, but instead of pointing out the targets while watching, the video was suddenly masked and participants were asked to locate all targets which had been present just before the masking, choosing among several possible locations. Their performance was analyzed using Signal Detection Theory and answer latencies. The game decreased answer latency and marginally changed response bias in a less conservative direction for both children and adults, but it did not significantly increase sensitivity for targets. Adults performed better in the tests and in the game, and it was possible to satisfactorily predict group membership based on the scores. Children found it especially difficult to find covert targets. Overall, the described version of the

  3. A Goal-Function Approach to Analysis of Control Situations

    DEFF Research Database (Denmark)

    Lind, Morten

    2010-01-01

    The concept of situations plays a central role in all theories of meaning and context. and serve to frame or group events and other occurrences into coherent meaningful wholes. Situations are typed, may be interconnected and organized into higher level structures. In operation of industrial...... processes situations should identify operational aspects relevant for control agent’s decision making in plant supervision and control. Control situations can be understood as recurrent and interconnected patterns of control with important implications for control and HMI design. Goal-Function approaches...

  4. The didactic situation in geometry learning based on analysis of learning obstacles and learning trajectory

    Science.gov (United States)

    Sulistyowati, Fitria; Budiyono, Slamet, Isnandar

    2017-12-01

    This study aims to design a didactic situation based on the analysis of learning obstacles and learning trajectory on prism volume. The type of this research is qualitative and quantitative research with steps: analyzing the learning obstacles and learning trajectory, preparing the didactic situation, applying the didactic situation in the classroom, mean difference test of problem solving ability with t-test statistic. The subjects of the study were 8th grade junior high school students in Magelang 2016/2017 selected randomly from eight existing classes. The result of this research is the design of didactic situations that can be implemented in prism volume learning. The effectiveness of didactic situations that have been designed is shown by the mean difference test that is the problem solving ability of the students after the application of the didactic situation better than before the application. The didactic situation that has been generated is expected to be a consideration for teachers to design lessons that match the character of learners, classrooms and teachers themselves, so that the potential thinking of learners can be optimized to avoid the accumulation of learning obstacles.

  5. Uncertainties in thick-target PIXE analysis

    International Nuclear Information System (INIS)

    Campbell, J.L.; Cookson, J.A.; Paul, H.

    1983-01-01

    Thick-target PIXE analysis insolves uncertainties arising from the calculation of thick-target X-ray production in addition to the usual PIXE uncertainties. The calculation demands knowledge of ionization cross-sections, stopping powers and photon attenuation coefficients. Information on these is reviewed critically and a computational method is used to estimate the uncertainties transmitted from this data base into results of thick-target PIXE analyses with reference to particular specimen types using beams of 2-3 MeV protons. A detailed assessment of the accuracy of thick-target PIXE is presented. (orig.)

  6. Development and Present Situation Analysis of Power Transformer State Maintenance

    Science.gov (United States)

    Lv, Sen; Li, Biao; Li, Huan

    2018-02-01

    The pivotal status of power transformer in the power system is one of the most important equipment. The safety and reliability of its operation is directly related to the safety and stability of power system. Based on the analysis of the present situation of power transformer state maintenance in home and abroad. The paper points out the deficiency of the current method and provides a theoretical basis for further research, which has a certain guiding significance.

  7. Congestive heart failure, spouses' support and the couple's sleep situation: a critical incident technique analysis.

    Science.gov (United States)

    Broström, Anders; Strömberg, Anna; Dahlström, Ulf; Fridlund, Bengt

    2003-03-01

    Sleep related breathing disorders are common as well as a poor prognostic sign associated with higher mortality in patients with congestive heart failure (CHF). These patients often have a shorter total duration of sleep, disturbed sleep structure and increased daytime sleepiness, which can negatively affect all dimensions of the life situation. The spouse has an important role in supporting the patient in relation to sleep disorders, but this role may be adversely affected by the sleep situation of the couple. The aim of this study was to describe decisive situations that influence spouses' support to patients with CHF in relation to the couple's sleep situation. A qualitative descriptive design using critical incident technique was employed. Incidents were collected by means of interviews with 25 spouses of patients with CHF, strategically selected from two hospital-based specialist clinics in southern Sweden. Two main areas emerged in the analysis: support stimulating situations and support inhibiting situations. Support stimulating situations described how spouses' support was positively affected by their own adaptation in psychosocial or practical situations, and receiving help from others. Support inhibiting situations described how the spouses' support was negatively affected by sleep disturbances as a result of the patient's symptoms, anxiety in relation to the disease, limitations as a result of the sleeping habits, dissatisfaction with care related to the sleep situation, and being left to cope alone with the problems. An increased understanding of the stimulating and inhibiting situations influencing spouses' support for patients with CHF can guide health care personnel in deciding if an intervention is needed to improve the sleep situation for patient and spouse.

  8. A method for analysis of nuclear power plant operators' decision making in simulated disturbance situations

    International Nuclear Information System (INIS)

    1995-01-01

    An analysis method has been developed for analysis of nuclear power plant operators' decision making in simulated disturbance situations. The aim of the analysis is to investigate operators' orientation which is expected to manifest itself as collective strategies in utilization of resources of decision making. Resources analyzed here are different information sources and, in addition, collaborative resources like communication and participation. The cognitive approach on the basis of the method considers decision making as collective construction of common interpretation of available information. Utilization of information is evaluated with respect to operative context. This is made with help of conceptualization of the disturbance situation from the decision making point of view and by construction of operative reference for activity. The latter means conceptualization of the situation from the safety point of view and also consideration of other boundary constraints of decision making, i.e. economical and technical aspects. The analysis method is intended to be used in routine simulator training in nuclear power plants. By virtue of its contextual and dynamical approach it makes the developing nature of activity visible. Cumulation and distribution of knowledge of decision making as developing activity, controlled by orientation and boundary constraints of process control, is expected to improve operational culture of a plant organization. (author). 2 refs, 1 fig

  9. Motion state analysis of space target based on optical cross section

    Science.gov (United States)

    Tian, Qichen; Li, Zhi; Xu, Can; Liu, Chenghao

    2017-10-01

    In order to solve the problem that the movement state analysis method of the space target based on OCS is not related to the real motion state. This paper proposes a method based on OCS for analyzing the state of space target motion. This paper first establish a three-dimensional model of real STSS satellite, then change the satellite's surface into element, and assign material to each panel according to the actual conditions of the satellite. This paper set up a motion scene according to the orbit parameters of STSS satellite in STK, and the motion states are set to three axis steady state and slowly rotating unstable state respectively. In these two states, the occlusion condition of the surface element is firstly determined, and the effective face element is selected. Then, the coordinates of the observation station and the solar coordinates in the satellite body coordinate system are input into the OCS calculation program, and the OCS variation curves of the three axis steady state and the slow rotating unstable state STSS satellite are obtained. Combining the satellite surface structure and the load situation, the OCS change curve of the three axis stabilized satellite is analyzed, and the conclude that the OCS curve fluctuates up and down when the sunlight is irradiated to the load area; By using Spectral analysis method, autocorrelation analysis and the cross residual method, the rotation speed of OCS satellite in slow rotating unstable state is analyzed, and the rotation speed of satellite is successfully reversed. By comparing the three methods, it is found that the cross residual method is more accurate.

  10. Cross-Cultural Patterns of Attachment: A Meta-Analysis of t?Y Strange Situation.

    Science.gov (United States)

    van IJzendoorn, Marinus H.; Kroonenberg, Pieter M.

    1988-01-01

    Examines 2,000 Strange Situation classifications obtained in eight different countries. Differences and similarities between distributions in classifications of samples are investigated using correspondence analysis. Substantial intracultural differences are established; data also suggest a pattern of cross-cultural differences. (Author/RWB)

  11. Safety assessment of a lithium target

    International Nuclear Information System (INIS)

    Burgazzi, Luciano; Roberta, Ferri; Barbara, Giannone

    2006-01-01

    This paper addresses the safety assessment of the lithium target of the International Fusion Materials Irradiation Facility (IFMIF) through evaluating the most important risk factors related to system operation and verifying the fulfillment of the safety criteria. The hazard assessment is based on using a well-structured Failure Mode and Effect Analysis (FMEA) procedure by detailing on a component-by-component basis all the possible failure modes and identifying their effects on the plant. Additionally, a systems analysis, applying the fault tree technique, is performed in order to evaluate, from a probabilistic standpoint, all the relevant and possible failures of each component required for safe system operation and assessing the unavailability of the lithium target system. The last task includes the thermal-hydraulic transient analysis of the target lithium loop, including operational and accident transients. A lithium target loop model is developed, using the RELAP5/Mod3.2 thermal-hydraulic code, which has been modified to include specific features of IFMIF itself. The main conclusions are that target safety is fulfilled, the hazards associated with lithium operation are confined within the IFMIF security boundaries, the environmental impact is negligible, and the plant responds to the simulated transients by being able to reach steady conditions in a safety situation

  12. Fukushima 2015: situational analysis and perspectives

    International Nuclear Information System (INIS)

    Jouette, Isabelle; Le Ngoc, Boris

    2015-01-01

    This publication proposes an overview of the situation of the Fukushima-Daiichi nuclear power station, four years after the accident. It addresses how the situation is managed in terms of evacuation of nuclear fuels, of storage of contaminated water, and of temporary storage of radioactive wastes produced by decontamination activities. It addresses the decontamination of the environment and the return of populations: progress of decontamination, return of populations, and absence of contamination of food products. The next part addresses the perspectives for the Japanese nuclear sector: a strengthened nuclear safety authority, reactors ready to start up again (some reactors seem to be able to be authorized to soon start up again). It describes how French technology is involved at the service of Fukushima-Daiichi through the Onet Technologies project by the CEA (a remote controlled laser cutting process). It evokes the evolutions of safety requirements in France after the Fukushima accident, notably with the introduction of the hard core notion, and of the FARN or Fast Nuclear Task Force

  13. An Empirical Study on Needs Analysis of College Business English Course

    Science.gov (United States)

    Wu, Yan

    2012-01-01

    Under the theoretical framework of needs analysis, this paper is aimed to give insights into the college business English learners' needs (including target situation needs, learning situation needs and present situation needs). The analysis of the research data has provided teachers insights into business English teaching related issues.

  14. Understanding the Situation in the Urban Environment

    Science.gov (United States)

    2001-05-15

    discuss the cognitive aspect of enabling the urban decision maker to make optimal decisions. The manual updated many aspects of FM 90-10 in a...targets needed physical remedies for the urban fight, the program addresses little of the cognitive aspect of the soldier. The few situational

  15. Creating the learning situation to promote student deep learning: Data analysis and application case

    Science.gov (United States)

    Guo, Yuanyuan; Wu, Shaoyan

    2017-05-01

    How to lead students to deeper learning and cultivate engineering innovative talents need to be studied for higher engineering education. In this study, through the survey data analysis and theoretical research, we discuss the correlation of teaching methods, learning motivation, and learning methods. In this research, we find that students have different motivation orientation according to the perception of teaching methods in the process of engineering education, and this affects their choice of learning methods. As a result, creating situations is critical to lead students to deeper learning. Finally, we analyze the process of learning situational creation in the teaching process of «bidding and contract management workshops». In this creation process, teachers use the student-centered teaching to lead students to deeper study. Through the study of influence factors of deep learning process, and building the teaching situation for the purpose of promoting deep learning, this thesis provide a meaningful reference for enhancing students' learning quality, teachers' teaching quality and the quality of innovation talent.

  16. The France energy situation; La situation energetique de la France

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    This analysis of the french energy situation provides information and key data on some key facts about the energy in France, the France energy supply and demand, the major principles of energy policy, the challenges of french energy policy and the DGEMP (general directorate for energy and raw materials). (A.L.B.)

  17. Systematic Analysis of Video Data from Different Human-Robot Interaction Studies: A Categorisation of Social Signals During Error Situations

    OpenAIRE

    Manuel eGiuliani; Nicole eMirnig; Gerald eStollnberger; Susanne eStadler; Roland eBuchner; Manfred eTscheligi

    2015-01-01

    Human?robot interactions are often affected by error situations that are caused by either the robot or the human. Therefore, robots would profit from the ability to recognize when error situations occur. We investigated the verbal and non-verbal social signals that humans show when error situations occur in human?robot interaction experiments. For that, we analyzed 201 videos of five human?robot interaction user studies with varying tasks from four independent projects. The analysis shows tha...

  18. Latent class analysis of the feared situations of social anxiety disorder: A population-based study.

    Science.gov (United States)

    Peyre, Hugo; Hoertel, Nicolas; Rivollier, Fabrice; Landman, Benjamin; McMahon, Kibby; Chevance, Astrid; Lemogne, Cédric; Delorme, Richard; Blanco, Carlos; Limosin, Frédéric

    2016-12-01

    Little is known about differences in mental health comorbidity and quality of life in individuals with social anxiety disorder (SAD) according to the number and the types of feared situations. Using a US nationally representative sample, the National Epidemiologic Survey on Alcohol and Related Conditions, we performed latent class analysis to compare the prevalence rates of mental disorders and quality of life measures across classes defined by the number and the types of feared social situations among individuals with SAD. Among the 2,448 participants with a lifetime diagnosis of SAD, we identified three classes of individuals who feared most social situations but differed in the number of feared social situations (generalized severe [N = 378], generalized moderate [N = 1,049] and generalized low [N = 443]) and a class of subjects who feared only performance situations [N = 578]. The magnitude of associations between each class and a wide range of mental disorders and quality of life measures were consistent with a continuum model, supporting that the deleterious effects of SAD on mental health may increase with the number of social situations feared. However, we found that individuals with the "performance only" specifier may constitute an exception to this model because these participants had significantly better mental health than other participants with SAD. Our findings give additional support to the recent changes made in the DSM-5, including the introduction of the "performance only" specifier and the removal of the "generalized" specifier to promote the dimensional approach of the number of social fears. © 2016 Wiley Periodicals, Inc.

  19. Using the Concept of the "Total Situation" in the Analysis of a Borderline Adolescent

    Science.gov (United States)

    Diem-Wille, Gertraud

    2004-01-01

    The author discusses two concepts of transference: the broader use of transference as the "total situation", as it was called by Melanie Klein and further elaborated by post-Kleinians, and the narrow use of transference in the traditional sense. Using clinical material from the four-times-a-week analysis of a severely disturbed…

  20. Crisis Situations in Engineering Product Development

    DEFF Research Database (Denmark)

    Muenzberg, Christopher; Hammer, Jens; Brem, Alexander

    2016-01-01

    approaches reduce the problem identification time and increase the efficiency of crisis management. The goal of this research is to identify methods which are able to support the crisis management process successfully. Therefore, a literature-based analysis of developing methods, especially TRIZ is conducted......Crisis situations are special situations during the development process. They are characterized by time and handling pressure. Therefore, it is necessary to identify and apply a methodical problem solving approach to overcome these situations. Due to their prescriptive character, problem solving...

  1. Situational analysis of the microbial water quality in a peri-urban catchment in South Africa

    CSIR Research Space (South Africa)

    Venter, SN

    1997-01-01

    Full Text Available A situational analysis of a peri-urban catchment experiencing microbial water quality problems was carried out using data collected over two and a half years. The water and land use in the area was determined. The main sources of pollution were...

  2. Study on Reverse Reconstruction Method of Vehicle Group Situation in Urban Road Network Based on Driver-Vehicle Feature Evolution

    Directory of Open Access Journals (Sweden)

    Xiaoyuan Wang

    2017-01-01

    Full Text Available Vehicle group situation is the status and situation of dynamic permutation which is composed of target vehicle and neighboring traffic entities. It is a concept which is frequently involved in the research of traffic flow theory, especially the active vehicle security. Studying vehicle group situation in depth is of great significance for traffic safety. Three-lane condition was taken as an example; the characteristics of target vehicle and its neighboring vehicles were synthetically considered to restructure the vehicle group situation in this paper. The Gamma distribution theory was used to identify the vehicle group situation when target vehicle arrived at the end of the study area. From the perspective of driver-vehicle feature evolution, the reverse reconstruction method of vehicle group situation in the urban road network was proposed. Results of actual driving, virtual driving, and simulation experiments showed that the model established in this paper was reasonable and feasible.

  3. Situation-specific theories from the middle-range transitions theory.

    Science.gov (United States)

    Im, Eun-Ok

    2014-01-01

    The purpose of this article was to analyze the theory development process of the situation-specific theories that were derived from the middle-range transitions theory. This analysis aims to provide directions for future development of situation-specific theories. First, transitions theory is concisely described with its history, goal, and major concepts. Then, the approach that was used to retrieve the situation-specific theories derived from transitions theory is described. Next, an analysis of 6 situation-specific theories is presented. Finally, 4 themes reflecting commonalities and variances in the theory development process are discussed with implications for future theoretical development.

  4. Situated Analysis of Team Handball Players' Decisions: An Exploratory Study

    Science.gov (United States)

    Lenzen, Benoit; Theunissen, Catherine; Cloes, Marc

    2009-01-01

    This exploratory study aimed to investigate elements involved in decision making in team handball live situations and to provide coaches and educators with teaching recommendations. The study was positioned within the framework of the situated-action paradigm of which two aspects were of particular interest for this project: (a) the relationship…

  5. Road safety risk evaluation and target setting using data envelopment analysis and its extensions.

    Science.gov (United States)

    Shen, Yongjun; Hermans, Elke; Brijs, Tom; Wets, Geert; Vanhoof, Koen

    2012-09-01

    Currently, comparison between countries in terms of their road safety performance is widely conducted in order to better understand one's own safety situation and to learn from those best-performing countries by indicating practical targets and formulating action programmes. In this respect, crash data such as the number of road fatalities and casualties are mostly investigated. However, the absolute numbers are not directly comparable between countries. Therefore, the concept of risk, which is defined as the ratio of road safety outcomes and some measure of exposure (e.g., the population size, the number of registered vehicles, or distance travelled), is often used in the context of benchmarking. Nevertheless, these risk indicators are not consistent in most cases. In other words, countries may have different evaluation results or ranking positions using different exposure information. In this study, data envelopment analysis (DEA) as a performance measurement technique is investigated to provide an overall perspective on a country's road safety situation, and further assess whether the road safety outcomes registered in a country correspond to the numbers that can be expected based on the level of exposure. In doing so, three model extensions are considered, which are the DEA based road safety model (DEA-RS), the cross-efficiency method, and the categorical DEA model. Using the measures of exposure to risk as the model's input and the number of road fatalities as output, an overall road safety efficiency score is computed for the 27 European Union (EU) countries based on the DEA-RS model, and the ranking of countries in accordance with their cross-efficiency scores is evaluated. Furthermore, after applying clustering analysis to group countries with inherent similarity in their practices, the categorical DEA-RS model is adopted to identify best-performing and underperforming countries in each cluster, as well as the reference sets or benchmarks for those

  6. Correlation of microRNA levels during hypoxia with predicted target mRNAs through genome-wide microarray analysis

    Directory of Open Access Journals (Sweden)

    Page Grier P

    2009-03-01

    Full Text Available Abstract Background Low levels of oxygen in tissues, seen in situations such as chronic lung disease, necrotic tumors, and high altitude exposures, initiate a signaling pathway that results in active transcription of genes possessing a hypoxia response element (HRE. The aim of this study was to investigate whether a change in miRNA expression following hypoxia could account for changes in the cellular transcriptome based on currently available miRNA target prediction tools. Methods To identify changes induced by hypoxia, we conducted mRNA- and miRNA-array-based experiments in HT29 cells, and performed comparative analysis of the resulting data sets based on multiple target prediction algorithms. To date, few studies have investigated an environmental perturbation for effects on genome-wide miRNA levels, or their consequent influence on mRNA output. Results Comparison of miRNAs with predicted mRNA targets indicated a lower level of concordance than expected. We did, however, find preliminary evidence of combinatorial regulation of mRNA expression by miRNA. Conclusion Target prediction programs and expression profiling techniques do not yet adequately represent the complexity of miRNA-mediated gene repression, and new methods may be required to better elucidate these pathways. Our data suggest the physiologic impact of miRNAs on cellular transcription results from a multifaceted network of miRNA and mRNA relationships, working together in an interconnected system and in context of hundreds of RNA species. The methods described here for comparative analysis of cellular miRNA and mRNA will be useful for understanding genome wide regulatory responsiveness and refining miRNA predictive algorithms.

  7. Netvertising and ESP: genre-based analysis of target advertisements and its application in the Business English classroom

    Directory of Open Access Journals (Sweden)

    Juan Carlos Palmer

    1999-04-01

    Full Text Available There is a new trend in genre-analysis studies which is starting to pay attention to the study of technology for academic and teaching purposes. Different authors have re-defined genre, adding to the concept not just form or structure, but also content, situation, context and communicative purposes. The present analysis is a detailed study on how new Internet genres can play an important role in the Business English classroom. We have studied a corpus of 40 first page target ads, of which 20 introduced products, whereas the other 20 were created in order to offer information about different types of services. We have analysed sub-generic similarities and differences considering five different aspects: objectives, register, language, content units and the author’s presence in the resulting text. Conclusions are drawn from this study, emphasising how this type of ads can be used in the Business English classroom.

  8. France energy situation

    International Nuclear Information System (INIS)

    1991-01-01

    The monthly (May 1991) energy situation analysis in France is presented: the energy consumption rise is lowered and especially, oil imports have fallen from -3.1 pc; natural gas imports and domestic electric power production have risen. The energy import dependence rate have very slightly risen, around 50 pc. Diagrams for 1989, 1990, 1991 are presented [fr

  9. CFD analysis of the HYPER spallation target

    International Nuclear Information System (INIS)

    Cho, Chungho; Tak, Nam-il; Choi, Jae-Hyuk; Lee, Yong-Bum

    2008-01-01

    KAERI (Korea Atomic Energy Research Institute) is developing an accelerator driven system (ADS) named HYPER (HYbrid Power Extraction Reactor) for a transmutation of long-lived nuclear wastes. One of the challenging tasks for the HYPER system is to design a large spallation target with a beam power of 15-25 MW. The paper focuses on a thermal-hydraulic analysis of the active part of the HYPER target. Computational fluid dynamics (CFD) analysis was performed by using a commercial code CFX 5.7.1. Several advanced turbulence models with different grid structures were applied. The CFX results reveal a significant impact of the turbulence model on the window temperature. Particularly, the k-ε model predicts the lowest window temperature among the five investigated turbulence models

  10. Housing Accessibility Methodology Targeting Older People

    DEFF Research Database (Denmark)

    Helle, Tina

    accessibility problems before the planning of housing intervention strategies. It is also critical that housing standards addressing accessibility intended to accommodate people with functional limitations are valid in the sense that their definitions truly support accessibility. However, there is a paucity...... of valid and reliable assessment instruments targeting housing accessibility, and in-depth analysis of factors potentially impacting on reliability in complex assessment situations is remarkably absent. Moreover, the knowledge base informing the housing standards appears to be vague. We may therefore...... reasonably question the validity of the housing standards addressing accessibility. This thesis addresses housing accessibility methodology in general and the reliability of assessment and the validity of standards targeting older people with functional limitations and a dependence on mobility devices...

  11. Molecular Composition Analysis of Distant Targets

    Science.gov (United States)

    Hughes, Gary B.; Lubin, Philip

    2017-01-01

    This document is the Final Report for NASA Innovative Advanced Concepts (NIAC) Phase I Grant 15-NIAC16A-0145, titled Molecular Composition Analysis of Distant Targets. The research was focused on developing a system concept for probing the molecular composition of cold solar system targets, such as Asteroids, Comets, Planets and Moons from a distant vantage, for example from a spacecraft that is orbiting the target (Hughes et al., 2015). The orbiting spacecraft is equipped with a high-power laser, which is run by electricity from photovoltaic panels. The laser is directed at a spot on the target. Materials on the surface of the target are heated by the laser beam, and begin to melt and then evaporate, forming a plume of asteroid molecules in front of the heated spot. The heated spot glows, producing blackbody illumination that is visible from the spacecraft, via a path through the evaporated plume. As the blackbody radiation from the heated spot passes through the plume of evaporated material, molecules in the plume absorb radiation in a manner that is specific to the rotational and vibrational characteristics of the specific molecules. A spectrometer aboard the spacecraft is used to observe absorption lines in the blackbody signal. The pattern of absorption can be used to estimate the molecular composition of materials in the plume, which originated on the target. Focusing on a single spot produces a borehole, and shallow subsurface profiling of the targets bulk composition is possible. At the beginning of the Phase I research, the estimated Technology Readiness Level (TRL) of the system was TRL-1. During the Phase I research, an end-to-end theoretical model of the sensor system was developed from first principles. The model includes laser energy and optical propagation, target heating, melting and evaporation of target material, plume density, thermal radiation from the heated spot, molecular cross section of likely asteroid materials, and estimation of the

  12. Situational Causes of Offending: A Fixed-Effects Analysis of Space-Time Budget Data

    NARCIS (Netherlands)

    Bernasco, W.; Ruiter, S.; Bruinsma, G.J.N.; Pauwels, L.J.R; Weerman, F.M.

    2013-01-01

    Situational theories of crime assert that the situations that people participate in contain the proximal causes of crime. Prior research has not tested situational hypotheses rigorously, either for lack of detailed situational data or for lack of analytical rigor. The present research combines

  13. Energy situation november 2002

    International Nuclear Information System (INIS)

    2002-12-01

    The monthly situation analysis in France is presented. Statistics are given for energy consumption, demand, import and export. A special attention is given to the primary energy, the solid fuels, the petroleum products, the natural gas and the electric power. (A.L.B.)

  14. Energy situation August 2002

    International Nuclear Information System (INIS)

    2002-09-01

    The monthly situation analysis in France is presented. Statistics are given for energy consumption, demand, import and export. A special attention is given to the primary energy, the solid fuels, the petroleum products, the natural gas and the electric power. (A.L.B.)

  15. Systematic analysis of video data from different human–robot interaction studies: a categorization of social signals during error situations

    Science.gov (United States)

    Giuliani, Manuel; Mirnig, Nicole; Stollnberger, Gerald; Stadler, Susanne; Buchner, Roland; Tscheligi, Manfred

    2015-01-01

    Human–robot interactions are often affected by error situations that are caused by either the robot or the human. Therefore, robots would profit from the ability to recognize when error situations occur. We investigated the verbal and non-verbal social signals that humans show when error situations occur in human–robot interaction experiments. For that, we analyzed 201 videos of five human–robot interaction user studies with varying tasks from four independent projects. The analysis shows that there are two types of error situations: social norm violations and technical failures. Social norm violations are situations in which the robot does not adhere to the underlying social script of the interaction. Technical failures are caused by technical shortcomings of the robot. The results of the video analysis show that the study participants use many head movements and very few gestures, but they often smile, when in an error situation with the robot. Another result is that the participants sometimes stop moving at the beginning of error situations. We also found that the participants talked more in the case of social norm violations and less during technical failures. Finally, the participants use fewer non-verbal social signals (for example smiling, nodding, and head shaking), when they are interacting with the robot alone and no experimenter or other human is present. The results suggest that participants do not see the robot as a social interaction partner with comparable communication skills. Our findings have implications for builders and evaluators of human–robot interaction systems. The builders need to consider including modules for recognition and classification of head movements to the robot input channels. The evaluators need to make sure that the presence of an experimenter does not skew the results of their user studies. PMID:26217266

  16. Systematic analysis of video data from different human-robot interaction studies: a categorization of social signals during error situations.

    Science.gov (United States)

    Giuliani, Manuel; Mirnig, Nicole; Stollnberger, Gerald; Stadler, Susanne; Buchner, Roland; Tscheligi, Manfred

    2015-01-01

    Human-robot interactions are often affected by error situations that are caused by either the robot or the human. Therefore, robots would profit from the ability to recognize when error situations occur. We investigated the verbal and non-verbal social signals that humans show when error situations occur in human-robot interaction experiments. For that, we analyzed 201 videos of five human-robot interaction user studies with varying tasks from four independent projects. The analysis shows that there are two types of error situations: social norm violations and technical failures. Social norm violations are situations in which the robot does not adhere to the underlying social script of the interaction. Technical failures are caused by technical shortcomings of the robot. The results of the video analysis show that the study participants use many head movements and very few gestures, but they often smile, when in an error situation with the robot. Another result is that the participants sometimes stop moving at the beginning of error situations. We also found that the participants talked more in the case of social norm violations and less during technical failures. Finally, the participants use fewer non-verbal social signals (for example smiling, nodding, and head shaking), when they are interacting with the robot alone and no experimenter or other human is present. The results suggest that participants do not see the robot as a social interaction partner with comparable communication skills. Our findings have implications for builders and evaluators of human-robot interaction systems. The builders need to consider including modules for recognition and classification of head movements to the robot input channels. The evaluators need to make sure that the presence of an experimenter does not skew the results of their user studies.

  17. Obstetric care in Brazil: An analysis of the situation

    Directory of Open Access Journals (Sweden)

    Marcia de Freitas

    2006-03-01

    Full Text Available Objective: To evaluate the situation of obstetric care in Brazil. Methods:Analysis of data from the Ministry of Health: Information System onMortality; Information System on Live Births; Information System onAmbulatory Care of the Brazilian Unified Health System; InformationSystem on Hospital Care of the Brazilian Unified Health System. Otherssource of data: the Brazilian Institute of Geography and Statistics.Results: Maternal mortality rate was 50.83/100000 live births in Brazil.Prenatal care in the Northern and Northeastern regions of the countrypresented the lowest number of prenatal care appointments (27% ofpregnant women with less than 3 appointments. Premature labor wasthe main diagnosis for hospital admission before delivery. The numberof obstetric beds exceeds the population demand throughout the country.The main causes of maternal deaths were direct causes. Conclusions:Maternal mortality rate in Brazil is high and the main causes of deathsare preventable and related to medical and non-medical factors.

  18. Techno-Economic analysis

    Energy Technology Data Exchange (ETDEWEB)

    Salvesen, F.; Sandgren, J. [KanEnergi AS, Rud (Norway)

    1997-12-31

    The present energy situation in the target area is summarized: 20 million inhabitants without electricity in north- west Russia, 50 % of the people in the Baltic`s without electricity, very high technical skills, biggest problems is the finance. The energy situation, the advantages of the renewables, the restrictions, and examples for possible technical solutions are reviewed on the basis of short analysis and experience with the Baltics and Russia

  19. Techno-Economic analysis

    Energy Technology Data Exchange (ETDEWEB)

    Salvesen, F; Sandgren, J [KanEnergi AS, Rud (Norway)

    1998-12-31

    The present energy situation in the target area is summarized: 20 million inhabitants without electricity in north- west Russia, 50 % of the people in the Baltic`s without electricity, very high technical skills, biggest problems is the finance. The energy situation, the advantages of the renewables, the restrictions, and examples for possible technical solutions are reviewed on the basis of short analysis and experience with the Baltics and Russia

  20. Energy situation, January 2006

    International Nuclear Information System (INIS)

    2006-03-01

    The monthly energy situation analysis in France, at January 2006, is presented. Statistics are given for energy consumption, demand, import and export. A special attention is given to the primary energy, the solid fuels, the petroleum products, the natural gas and the electric power. (A.L.B.)

  1. Energy situation november 2005

    International Nuclear Information System (INIS)

    2005-12-01

    The monthly energy situation analysis in France at November 2005 is presented. Statistics are given for energy consumption, demand, import and export. A special attention is given to the primary energy, the solid fuels, the petroleum products, the natural gas and the electric power. (A.L.B.)

  2. Penetration analysis of projectile with inclined concrete target

    Directory of Open Access Journals (Sweden)

    Kim S.B.

    2015-01-01

    Full Text Available This paper presents numerical analysis result of projectile penetration with concrete target. We applied dynamic material properties of 4340 steels, aluminium and explosive for projectile body. Dynamic material properties were measured with static tensile testing machine and Hopkinson pressure bar tests. Moreover, we used three concrete damage models included in LS-DYNA 3D, such as SOIL_CONCRETE, CSCM (cap model with smooth interaction and CONCRETE_DAMAGE (K&C concrete models. Strain rate effect for concrete material is important to predict the fracture deformation and shape of concrete, and penetration depth for projectiles. CONCRETE_DAMAGE model with strain rate effect also applied to penetration analysis. Analysis result with CSCM model shows good agreement with penetration experimental data. The projectile trace and fracture shapes of concrete target were compared with experimental data.

  3. Penetration analysis of projectile with inclined concrete target

    Science.gov (United States)

    Kim, S. B.; Kim, H. W.; Yoo, Y. H.

    2015-09-01

    This paper presents numerical analysis result of projectile penetration with concrete target. We applied dynamic material properties of 4340 steels, aluminium and explosive for projectile body. Dynamic material properties were measured with static tensile testing machine and Hopkinson pressure bar tests. Moreover, we used three concrete damage models included in LS-DYNA 3D, such as SOIL_CONCRETE, CSCM (cap model with smooth interaction) and CONCRETE_DAMAGE (K&C concrete) models. Strain rate effect for concrete material is important to predict the fracture deformation and shape of concrete, and penetration depth for projectiles. CONCRETE_DAMAGE model with strain rate effect also applied to penetration analysis. Analysis result with CSCM model shows good agreement with penetration experimental data. The projectile trace and fracture shapes of concrete target were compared with experimental data.

  4. Sentiment analysis enhancement with target variable in Kumar’s Algorithm

    Science.gov (United States)

    Arman, A. A.; Kawi, A. B.; Hurriyati, R.

    2016-04-01

    Sentiment analysis (also known as opinion mining) refers to the use of text analysis and computational linguistics to identify and extract subjective information in source materials. Sentiment analysis is widely applied to reviews discussion that is being talked in social media for many purposes, ranging from marketing, customer service, or public opinion of public policy. One of the popular algorithm for Sentiment Analysis implementation is Kumar algorithm that developed by Kumar and Sebastian. Kumar algorithm can identify the sentiment score of the statement, sentence or tweet, but cannot determine the relationship of the object or target related to the sentiment being analysed. This research proposed solution for that challenge by adding additional component that represent object or target to the existing algorithm (Kumar algorithm). The result of this research is a modified algorithm that can give sentiment score based on a given object or target.

  5. Using a situational judgement test for selection into dental core training: a preliminary analysis.

    Science.gov (United States)

    Rowett, E; Patterson, F; Cousans, F; Elley, K

    2017-05-12

    Objective and setting This paper describes the evaluation of a pilot situational judgement test (SJT) for selection into UK Dental Core Training (DCT). The SJT's psychometric properties, group differences based on gender and ethnicity, and candidate reactions were assessed.Methods The SJT targets four non-academic attributes important for success in DCT. Data were collected alongside live selection processes from five Health Education England local teams in the UK (N = 386). Candidates completed the pilot SJT and an evaluation questionnaire to examine their reactions to the test.Results SJT scores were relatively normally distributed and showed acceptable levels of internal reliability (α = 0.68). Difficulty level and partial correlations between scenarios and SJT total score were in the expected ranges (64.61% to 90.03% and r = 0.06 to 0.41, respectively). No group differences were found for gender, and group differences between White and BME candidates were minimal. Most candidates perceived the SJT as relevant to the target role, appropriate and fair.Conclusions This study demonstrated the potential suitability of an SJT for use in DCT selection. Future research should replicate these preliminary findings in other cohorts, and assess the predictive validity of the SJT for predicting key training and practice-based outcomes.

  6. The France energy situation

    International Nuclear Information System (INIS)

    2006-01-01

    This analysis of the french energy situation provides information and key data on some key facts about the energy in France, the France energy supply and demand, the major principles of energy policy, the challenges of french energy policy and the DGEMP (general directorate for energy and raw materials). (A.L.B.)

  7. Personality and Situation Predictors of Consistent Eating Patterns.

    Science.gov (United States)

    Vainik, Uku; Dubé, Laurette; Lu, Ji; Fellows, Lesley K

    2015-01-01

    A consistent eating style might be beneficial to avoid overeating in a food-rich environment. Eating consistency entails maintaining a similar dietary pattern across different eating situations. This construct is relatively under-studied, but the available evidence suggests that eating consistency supports successful weight maintenance and decreases risk for metabolic syndrome and cardiovascular disease. Yet, personality and situation predictors of consistency have not been studied. A community-based sample of 164 women completed various personality tests, and 139 of them also reported their eating behaviour 6 times/day over 10 observational days. We focused on observations with meals (breakfast, lunch, or dinner). The participants indicated if their momentary eating patterns were consistent with their own baseline eating patterns in terms of healthiness or size of the meal. Further, participants described various characteristics of each eating situation. Eating consistency was positively predicted by trait self-control. Eating consistency was undermined by eating in the evening, eating with others, eating away from home, having consumed alcohol and having undertaken physical exercise. Interactions emerged between personality traits and situations, including punishment sensitivity, restraint, physical activity and alcohol consumption. Trait self-control and several eating situation variables were related to eating consistency. These findings provide a starting point for targeting interventions to improve consistency, suggesting that a focus on self-control skills, together with addressing contextual factors such as social situations and time of day, may be most promising. This work is a first step to provide people with the tools they need to maintain a consistently healthy lifestyle in a food-rich environment.

  8. Personality and Situation Predictors of Consistent Eating Patterns.

    Directory of Open Access Journals (Sweden)

    Uku Vainik

    Full Text Available A consistent eating style might be beneficial to avoid overeating in a food-rich environment. Eating consistency entails maintaining a similar dietary pattern across different eating situations. This construct is relatively under-studied, but the available evidence suggests that eating consistency supports successful weight maintenance and decreases risk for metabolic syndrome and cardiovascular disease. Yet, personality and situation predictors of consistency have not been studied.A community-based sample of 164 women completed various personality tests, and 139 of them also reported their eating behaviour 6 times/day over 10 observational days. We focused on observations with meals (breakfast, lunch, or dinner. The participants indicated if their momentary eating patterns were consistent with their own baseline eating patterns in terms of healthiness or size of the meal. Further, participants described various characteristics of each eating situation.Eating consistency was positively predicted by trait self-control. Eating consistency was undermined by eating in the evening, eating with others, eating away from home, having consumed alcohol and having undertaken physical exercise. Interactions emerged between personality traits and situations, including punishment sensitivity, restraint, physical activity and alcohol consumption.Trait self-control and several eating situation variables were related to eating consistency. These findings provide a starting point for targeting interventions to improve consistency, suggesting that a focus on self-control skills, together with addressing contextual factors such as social situations and time of day, may be most promising. This work is a first step to provide people with the tools they need to maintain a consistently healthy lifestyle in a food-rich environment.

  9. Analysis of epidemiological situation of iodine deficiency in Tomsk region from 1998 to 2014

    Science.gov (United States)

    Samoilova, Y. G.; Oleynik, O. A.; Yurchenko, E. V.; Zinchuk, S. F.; Sivolobova, T. V.; Rotkank, M. A.; Mazhitova, D. S.

    2017-08-01

    The purpose of the present research is the comparative analysis of the epidemiological situation of iodine deficiency in the Tomsk region from 1998 to 2014. There were examined 9901 and 15174 children of the school age including within the medical examination of the children’s population in 1998 and 2014 in Tomsk. At all school pupils there were analyzed anamnestic data and carried out anthropometrical measurements, ultrasonography of the thyroid gland was carried out using the portable scanner "Aloka SSD 500" with the linear sensor of 7,5 MHz frequency in the real time, the thyroid volume was evaluated according to Delange (1997). The excretion of inorganic iodine was determined at 264 in 1998 and at 120 children in 2014, respectively, in a one-time portion of urine by the cerium-arsenic method. There was additionally carried out the analysis of results of determination of TSH at 10717 in 1998, and at 15091 in 2014 in a spot of the whole blood at newborn children on the 4-5 day after birth at full-term and on the 7-14 day at prematurely born children. Neonatal TSH in the dried-up samples of capillary blood was determined by the method of the fluorometric immune-ferment analysis with the use of sets of TSH-Neonatal: Delfia, Finland. Statistical processing of the data obtained was carried out with the use of the applied software package pspp. The descriptive analysis included calculation of the median for the quantitative and the calculation of frequencies for qualitative data. The comparative analysis included calculation of distinctions reliability by the Mann-Whitney criterion for independent and to Wilcoxon’s criterion for dependent data. The comparative analysis of epidemiological situation of iodine deficiency in Tomsk and the Tomsk region in 1998 and 2014 specifies decreasing the iodine deficiency diseases in the Tomsk region, increasing the iodine provision of the population within 15 years by 27%, decreasing neonatal hyperthyroidism by 1.5 times.

  10. Thermal analysis of titanium drive-in target for D-D neutron generation.

    Science.gov (United States)

    Jung, N S; Kim, I J; Kim, S J; Choi, H D

    2010-01-01

    Thermal analysis was performed for a titanium drive-in target of a D-D neutron generator. Computational fluid dynamics code CFX-5 was used in this study. To define the heat flux term for the thermal analysis, beam current profile was measured. Temperature of the target was calculated at some of the operating conditions. The cooling performance of the target was evaluated by means of the comparison of the calculated maximum target temperature and the critical temperature of titanium. Copyright 2009 Elsevier Ltd. All rights reserved.

  11. Situation and perspective of spent fuel management in Spain

    International Nuclear Information System (INIS)

    Lopez Garcia, A.

    2009-01-01

    Between september 2006 and september 2007, the Foundation for Energy Studies carried out the study Radioactive Waste Management: Situation, Analysis and Perspectives. This study focuses specially on spent fuel and high level radioactive waste management. The different aspects covered in this study are as follows: -Description of the different applicable technologies -Analysis and comparison of the different options of spent fuel management, including the strategic and economic aspects. - Situation, strategies and forecasts in the main countries. -Analysis of the situation and alternatives for the spent fuel management in spain. Although the report focuses principally pn the technological and environmental aspects other issues related with the management of these materials were considered, such as the strategic, economic and institutional aspects as well as the social acceptation. In answer to the request of the SNE publication, the article enclosed is a summary of one of the chapters of this study, and more particularly the one dedicated to the situation of spent fuel and high level radioactive waste management in Spain. (Author)

  12. [Situational low self-esteem in pregnant women: an analysis of accuracy].

    Science.gov (United States)

    Cavalcante, Joyce Carolle Bezerra; de Sousa, Vanessa Emille Carvalho; Lopes, Marcos Venícios de Oliveira

    2012-01-01

    To investigate the accuracy of defining characteristics of Situational low self-esteem we developed a cross-sectional study, with 52 pregnant women assisted in a family centre. The NANDA-I taxonomy was used as well as the Rosenberg's scale. The diagnosis was present in 32.7% of the sample and all characteristics presented statistical significance, except "Reports verbally situational challenge to its own value". The characteristics "Indecisive behavior" and "Helplessness expressions" had 82.35% of sensitivity. On the other hand, the characteristics "Expression of feelings of worthlessness" and "Reports verbally situational challenge to its own value" were the more specific, with 94.29% of specificity. These results can contribute with the nursing practice because the identification of accurate characteristics is essential to a secure inference.

  13. Emergency situations; Les situations d'urgence

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    The nuclear activities are exercised so as to prevent the accidents. They are subjected to a rule whom application is controlled by the Asn. The risk of grave accident is so limited to a very low level of probability. He cannot be however completely pushed aside. The expression ' radiological emergency situation ' indicates a situation which ensues from an incident or of an accident risking to lead to an emission of radioactive materials or a level of radioactivity susceptible to strike a blow at the public health. The term ' nuclear crisis ' is used for the events which can lead to a radiological emergency situation on a nuclear basic installation or during a transport of radioactive materials. The preparation and the management of emergency situations, that they are of natural, accidental or terrorist origin, became a major concern of our society. We propose you of to know more about it in this file. (N.C.)

  14. Nuclear situation in Japan; La situation du nucleaire au Japon

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    This analysis takes stock on the nuclear situation in Japan. It discusses the ambitious equipment program in collaboration with the France, the destabilization of the japanese nuclear industry following the accidents and the energy policy evolutions. It presents the projects of the japanese nuclear industry: the Monju reactor restart, the Pluthermal project, the reprocessing power plant of Rokkasho Mura, the new reactors, the russian weapons dismantling, the ITER site selection and the buy out of Westinghouse by Toshiba. (A.L.B.)

  15. Mission Command in the Age of Network-Enabled Operations: Social Network Analysis of Information Sharing and Situation Awareness.

    Science.gov (United States)

    Buchler, Norbou; Fitzhugh, Sean M; Marusich, Laura R; Ungvarsky, Diane M; Lebiere, Christian; Gonzalez, Cleotilde

    2016-01-01

    A common assumption in organizations is that information sharing improves situation awareness and ultimately organizational effectiveness. The sheer volume and rapid pace of information and communications received and readily accessible through computer networks, however, can overwhelm individuals, resulting in data overload from a combination of diverse data sources, multiple data formats, and large data volumes. The current conceptual framework of network enabled operations (NEO) posits that robust networking and information sharing act as a positive feedback loop resulting in greater situation awareness and mission effectiveness in military operations (Alberts and Garstka, 2004). We test this assumption in a large-scale, 2-week military training exercise. We conducted a social network analysis of email communications among the multi-echelon Mission Command staff (one Division and two sub-ordinate Brigades) and assessed the situational awareness of every individual. Results from our exponential random graph models challenge the aforementioned assumption, as increased email output was associated with lower individual situation awareness. It emerged that higher situation awareness was associated with a lower probability of out-ties, so that broadly sending many messages decreased the likelihood of attaining situation awareness. This challenges the hypothesis that increased information sharing improves situation awareness, at least for those doing the bulk of the sharing. In addition, we observed two trends that reflect a compartmentalizing of networked information sharing as email links were more commonly formed among members of the command staff with both similar functions and levels of situation awareness, than between two individuals with dissimilar functions and levels of situation awareness; both those findings can be interpreted to reflect effects of homophily. Our results have major implications that challenge the current conceptual framework of NEO. In

  16. Error Analysis of Fast Moving Target Geo-location in Wide Area Surveillance Ground Moving Target Indication Mode

    Directory of Open Access Journals (Sweden)

    Zheng Shi-chao

    2013-12-01

    Full Text Available As an important mode in airborne radar systems, Wide Area Surveillance Ground Moving Target Indication (WAS-GMTI mode has the ability of monitoring a large area in a short time, and then the detected moving targets can be located quickly. However, in real environment, many factors introduce considerable errors into the location of moving targets. In this paper, a fast location method based on the characteristics of the moving targets in WAS-GMTI mode is utilized. And in order to improve the location performance, those factors that introduce location errors are analyzed and moving targets are relocated. Finally, the analysis of those factors is proved to be reasonable by simulation and real data experiments.

  17. Gender-related aspects of transmasculine people's vocal situations: insights from a qualitative content analysis of interview transcripts.

    Science.gov (United States)

    Azul, David

    2016-11-01

    Transmasculine people assigned female gender at birth but who do not identify with this classification have traditionally received little consideration in the voice literature. Existing analyses tend to be focused on evaluating speaker voice characteristics, whereas other factors that contribute to the production of vocal gender have remained underexplored. Most studies rely on researcher-centred perspectives, whereas very little is known about how transmasculine people themselves experience and make sense of their vocal situations. To explore how participants described their subjective gender positionings; which gender attributions they wished to receive from others; which gender they self-attributed to their voices; which gender attributions they had received from others; and how far participants were satisfied with the gender-related aspects of their vocal situations. Transcripts of semi-structured interviews with 14 German-speaking transmasculine people served as the original data corpus. Sections in which participants described the gender-related aspects of their vocal situations and that were relevant to the current research objectives were selected and explored using qualitative content analysis. The analysis revealed diverse accounts pertaining to the factors that contribute to the production of vocal gender for individual participants and variable levels of satisfaction with vocal gender presentation and attribution. Transmasculine people need to be regarded as a heterogeneous population and clinical practice needs to follow a client-centred, individualized approach. © 2016 Royal College of Speech and Language Therapists.

  18. Analysis of the basic professional standards involving the work of psychologists in difficult and legally significant situations

    Directory of Open Access Journals (Sweden)

    Bogdanovich N. V.

    2016-06-01

    Full Text Available In this article the analysis of professional standards in terms of the scope of work of the psychologist with clients in difficult life and legal situations. The criteria of analysis chosen: reflected in professional activities, the choice of grounds for the selection of professional activities that focus on a specific Department, selection of a particular direction of activity of the psychologist (prevention, support, rehabilitation. It is shown that all five of the analyzed standards imply such a situation, but only three of them ("educational psychologist", "Psychologist in the social sphere", "Specialist in rehabilitative work in the social sphere" describe the activities of the psychologist, and the remaining ("Expert of bodies of guardianship and guardianship concerning minors" and "Specialist in working with families" are more organizational in nature. The conclusion about compliance of the training programs developed by the Department of legal psychology and law and education, the requirements of professional standards, proposed improvements in these programs.

  19. Preliminary analysis of a target factory for laser fusion

    International Nuclear Information System (INIS)

    Sherohman, J.W.; Hendricks, C.D.

    1980-01-01

    An analysis of a target factory leading to the determination of production expressions has provided for the basis of a parametric study. Parameters involving the input and output rate of a process system, processing yield factors, and multiple processing steps and production lines have been used to develop an understanding of their dependence on the rate of target injection for laser fusion. Preliminary results have indicated that a parametric study of this type will be important in the selection of processing methods to be used in the final production scheme of a target factory

  20. A Qualitative Analysis of Power Differentials in Ethical Situations in Academia

    Science.gov (United States)

    Gibson, Carter; Medeiros, Kelsey E.; Giorgini, Vincent; Mecca, Jensen T.; Devenport, Lynn D.; Connelly, Shane; Mumford, Michael D.

    2014-01-01

    Power and organizational hierarchies are ubiquitous to social institutions that form the foundation of modern society. Power differentials may act to constrain or enhance people's ability to make good ethical decisions. However, little scholarly work has examined perceptions of this important topic. The present effort seeks to address this issue by interviewing academics about hypothetical ethical problems that involve power differences among those involved. Academics discussed what they would do in these scenarios, often drawing on their own experiences. Using a think-aloud protocol, participants were prompted to discuss their reasoning and thinking behind their ethical decisions. These interview data were content analyzed using a semantic analysis program that identified a number of distinct ways that academics think about power differences and abuses in ethical situations. Implications of these findings are discussed. PMID:25356066

  1. PROGNOSYS AND ANALYSIS OF DOSIMETRIC SITUATION AFTER EMERGENCY ATMOSPHERIC RELEASE OF NPP IN UKRAINE

    Directory of Open Access Journals (Sweden)

    Iu. V. Bonchuk

    2009-01-01

    Full Text Available The system for the operative analysis of dosimetric situation after radiation emergencies at nuclear power plants in Ukraine (KADO is developed for decision making support. Emergency release in KADO is modelled as sequence of the discrete elements which are emitted after small time intervals that allows to take into account in calculations heterogeneity of distribution of pollution in a released cloud. Calculated predicted and avertable doses are the base information for justification of emergency and urgent countermeasures.

  2. Power law of distribution of emergency situations on main gas pipeline

    Science.gov (United States)

    Voronin, K. S.; Akulov, K. A.

    2018-05-01

    The article presents the results of the analysis of emergency situations on a main gas pipeline. A power law of distribution of emergency situations is revealed. The possibility of conducting further scientific research to ensure the predictability of emergency situations on pipelines is justified.

  3. Analysis of target implosion irradiated by proton beam, (1)

    International Nuclear Information System (INIS)

    Tamba, Moritake; Nagata, Norimasa; Kawata, Shigeo; Niu, Keishiro.

    1982-10-01

    Numerical simulation and analysis were performed for the implosion of a hollow shell target driven by proton beam. The target consists of three layers of Pb, Al and DT. As the Al layer is heated by proton beam, the layer expands and pushes the DT layer toward the target center. To obtain the optimal velocity of DT implosion, the optimal target size and optimal layer thickness were determined. The target size is determined by, for example, the instability of the implosion or beam focusing on the target surface. The Rayleigh-Taylor instability and the unstable implosion due to the inhomogeneity were investigated. Dissipation, nonlinear effects and density gradient at the boundary were expected to reduce the growth rate of the Rayleigh-Taylor instability during the implosion. In order that the deviation of the boundary surface during the implosion is less than the thickness of fuel, the inhomogeneity of the temperature and the density of the target should be less than ten percent. The amplitude of the boundary surface roughness is required to be less than 4 micrometer. (Kato, T.)

  4. Simulation of visual search in the natural 2-D situation

    Directory of Open Access Journals (Sweden)

    Blanka Borin

    2004-08-01

    Full Text Available The goal of this research was to imitate the process of visual search in a natural two-dimensional situation and also to investigate the influence of variable features on the speed of the visual search. The experiment was designed upon one of the most influential theories in the research field of the visual search phenomenon – The Feature Integration Theory (Treisman, 1982. Although the FIT theory claims, that in case of a larger number of synchronous targets the mechanism of attention serially directs the mental processing from one target towards another, the results of our experiment has shown the possibility of not just serial but also parallel visual search. The results of the experiment have also shown that the similarity between features of the target and its surroundings takes effect on the speed of the target recognition. If the features are very similar or if there is no difference between the target and its surroundings, the visual search for the target is longer in comparison to the visual search for the target, which features don't resemble the target's surroundings.

  5. [Relationship among weblog authors' target audience, contents, and types of interpersonal communication].

    Science.gov (United States)

    Miura, Asako; Matsumura, Naohiro; Kitayama, Satoshi

    2008-12-01

    Weblogs are one of the most popular personal websites in Japan, where entries are made in journal style and displayed in reverse chronological order. This study examined the relationship between weblog authors' target audience (i.e., orientation) and the actual situations depicted in their weblogs by combining a questionnaire survey of the authors with an analysis of their weblog content data. Based on a questionnaire survey of 736 Japanese weblog authors, their target audience was divided into four clusters: (a) general public, (b) self, (c) self and offline friends, and (d) various others. To assess the actual situations depicted in their weblogs, the amount of happy and unhappy emotional expression in their writing and the frequency of interpersonal communication (comments, bookmarks, and trackbacks) were calculated from their log data. The results suggested that weblog authors wrote different types of content and used different types of communication depending on their audience, whereas the weblog content itself still showed the diary-like characteristic of personal daily-life records.

  6. Polarized targets and beams

    International Nuclear Information System (INIS)

    Meyer, W.

    1985-01-01

    First the experimental situation of the single-pion photoproduction and the photodisintegration of the deuteron is briefly discussed. Then a description of the Bonn polarization facilities is given. The point of main effort is put on the polarized target which plays a vital role in the program. A facility for photon induced double polarization experiments at ELSA will be presented in section 4. Properties of a tensor polarized deuteron target are discussed in section 5. The development in the field of polarized targets, especially on new target materials, enables a new generation of polarized target experiments with (polarized) electrons. Some comments on the use of a polarized target in combination with electron beams will be discussed in section 6. Electron deuteron scattering from a tensor polarized deuteron target is considered and compared with other experimental possibilities. (orig./HSI)

  7. Analysis of the situation in the textile industry in Мacedonia through four quality pillars

    OpenAIRE

    Mitreva, Elizabeta; Risteski, Sanja; Srebrenkoska, Vineta; Lazarevski, Ilija

    2016-01-01

    In this paper is elaborated and confirmed the need of projection and implementation of total quality management (TQM) system within Macedonian textile factories. Quality should be required not only in the production process, but in all parts of the business processes, even in the way the employees behave. An analysis is made on the situation in the textile industry in Macedonia and its progress through the four quality pillars: internal standardization, statistical process control appliance, ...

  8. Improving Global Multi-target Tracking with Local Updates

    DEFF Research Database (Denmark)

    Milan, Anton; Gade, Rikke; Dick, Anthony

    2014-01-01

    -target tracker, if they result in a reduction in the global cost function. Since tracking failures typically arise when targets become occluded, we propose a local data association scheme to maintain the target identities in these situations. We demonstrate a reduction of up to 50% in the global cost function...

  9. Analysis of directly driven ICF targets

    International Nuclear Information System (INIS)

    Velarde, G.; Aragones, J.M.; Gago, J.A.

    1986-01-01

    The current capabilities at DENIM for the analysis of directly driven targets are presented. These include theoretical, computational and applied physical studies and developments of detailed simulation models for the most relevant processes in ICF. The simulation of directly driven ICF targets is carried out with the one-dimensional NORCLA code developed at DENIM. This code contains two main segments: NORMA and CLARA, able to work fully coupled and in an iterative manner. NORMA solves the hydrodynamic equations in a lagrangian mesh. It has modular programs couple to it to treat the laser or particle beam interaction with matter. Equations of state, opacities and conductivities are taken from a DENIM atomic data library, generated externally with other codes that will also be explained in this work. CLARA solves the transport equation for neutrons, as well as for charged particles, and suprathermal electrons using discrete ordinates and finite element methods in the computational procedure. Parametric calculations of multilayered single-shell targets driven by heavy ion beams are also analyzed. Finally, conclusions are focused on the ongoing developments in the areas of interest such as: radiation transport, atomic physics, particle in cell method, charged particle transport, two-dimensional calculations and instabilities. (author)

  10. A mathematical analysis of multiple-target SELEX.

    Science.gov (United States)

    Seo, Yeon-Jung; Chen, Shiliang; Nilsen-Hamilton, Marit; Levine, Howard A

    2010-10-01

    SELEX (Systematic Evolution of Ligands by Exponential Enrichment) is a procedure by which a mixture of nucleic acids can be fractionated with the goal of identifying those with specific biochemical activities. One combines the mixture with a specific target molecule and then separates the target-NA complex from the resulting reactions. The target-NA complex is separated from the unbound NA by mechanical means (such as by filtration), the NA is eluted from the complex, amplified by PCR (polymerase chain reaction), and the process repeated. After several rounds, one should be left with the nucleic acids that best bind to the target. The problem was first formulated mathematically in Irvine et al. (J. Mol. Biol. 222:739-761, 1991). In Levine and Nilsen-Hamilton (Comput. Biol. Chem. 31:11-25, 2007), a mathematical analysis of the process was given. In Vant-Hull et al. (J. Mol. Biol. 278:579-597, 1998), multiple target SELEX was considered. It was assumed that each target has a single nucleic acid binding site that permits occupation by no more than one nucleic acid. Here, we revisit Vant-Hull et al. (J. Mol. Biol. 278:579-597, 1998) using the same assumptions. The iteration scheme is shown to be convergent and a simplified algorithm is given. Our interest here is in the behavior of the multiple target SELEX process as a discrete "time" dynamical system. Our goal is to characterize the limiting states and their dependence on the initial distribution of nucleic acid and target fraction components. (In multiple target SELEX, we vary the target component fractions, but not their concentrations, as fixed and the initial pool of nucleic acids as a variable starting condition). Given N nucleic acids and a target consisting of M subtarget component species, there is an M × N matrix of affinities, the (i,j) entry corresponding to the affinity of the jth nucleic acid for the ith subtarget. We give a structure condition on this matrix that is equivalent to the following

  11. Bioinformatics analysis of Brucella vaccines and vaccine targets using VIOLIN.

    Science.gov (United States)

    He, Yongqun; Xiang, Zuoshuang

    2010-09-27

    Brucella spp. are Gram-negative, facultative intracellular bacteria that cause brucellosis, one of the commonest zoonotic diseases found worldwide in humans and a variety of animal species. While several animal vaccines are available, there is no effective and safe vaccine for prevention of brucellosis in humans. VIOLIN (http://www.violinet.org) is a web-based vaccine database and analysis system that curates, stores, and analyzes published data of commercialized vaccines, and vaccines in clinical trials or in research. VIOLIN contains information for 454 vaccines or vaccine candidates for 73 pathogens. VIOLIN also contains many bioinformatics tools for vaccine data analysis, data integration, and vaccine target prediction. To demonstrate the applicability of VIOLIN for vaccine research, VIOLIN was used for bioinformatics analysis of existing Brucella vaccines and prediction of new Brucella vaccine targets. VIOLIN contains many literature mining programs (e.g., Vaxmesh) that provide in-depth analysis of Brucella vaccine literature. As a result of manual literature curation, VIOLIN contains information for 38 Brucella vaccines or vaccine candidates, 14 protective Brucella antigens, and 68 host response studies to Brucella vaccines from 97 peer-reviewed articles. These Brucella vaccines are classified in the Vaccine Ontology (VO) system and used for different ontological applications. The web-based VIOLIN vaccine target prediction program Vaxign was used to predict new Brucella vaccine targets. Vaxign identified 14 outer membrane proteins that are conserved in six virulent strains from B. abortus, B. melitensis, and B. suis that are pathogenic in humans. Of the 14 membrane proteins, two proteins (Omp2b and Omp31-1) are not present in B. ovis, a Brucella species that is not pathogenic in humans. Brucella vaccine data stored in VIOLIN were compared and analyzed using the VIOLIN query system. Bioinformatics curation and ontological representation of Brucella vaccines

  12. Targeted assembly of short sequence reads.

    Directory of Open Access Journals (Sweden)

    René L Warren

    Full Text Available As next-generation sequence (NGS production continues to increase, analysis is becoming a significant bottleneck. However, in situations where information is required only for specific sequence variants, it is not necessary to assemble or align whole genome data sets in their entirety. Rather, NGS data sets can be mined for the presence of sequence variants of interest by localized assembly, which is a faster, easier, and more accurate approach. We present TASR, a streamlined assembler that interrogates very large NGS data sets for the presence of specific variants by only considering reads within the sequence space of input target sequences provided by the user. The NGS data set is searched for reads with an exact match to all possible short words within the target sequence, and these reads are then assembled stringently to generate a consensus of the target and flanking sequence. Typically, variants of a particular locus are provided as different target sequences, and the presence of the variant in the data set being interrogated is revealed by a successful assembly outcome. However, TASR can also be used to find unknown sequences that flank a given target. We demonstrate that TASR has utility in finding or confirming genomic mutations, polymorphisms, fusions and integration events. Targeted assembly is a powerful method for interrogating large data sets for the presence of sequence variants of interest. TASR is a fast, flexible and easy to use tool for targeted assembly.

  13. Cross-situational statistically based word learning intervention for late-talking toddlers.

    Science.gov (United States)

    Alt, Mary; Meyers, Christina; Oglivie, Trianna; Nicholas, Katrina; Arizmendi, Genesis

    2014-01-01

    To explore the efficacy of a word learning intervention for late-talking toddlers that is based on principles of cross-situational statistical learning. Four late-talking toddlers were individually provided with 7-10 weeks of bi-weekly word learning intervention that incorporated principles of cross-situational statistical learning. Treatment was input-based meaning that, aside from initial probes, children were not asked to produce any language during the sessions. Pre-intervention data included parent-reported measures of productive vocabulary and language samples. Data collected during intervention included production on probes, spontaneous production during treatment, and parent report of words used spontaneously at home. Data were analyzed for number of target words learned relative to control words, effect sizes, and pre-post treatment vocabulary measures. All children learned more target words than control words and, on average, showed a large treatment effect size. Children made pre-post vocabulary gains, increasing their percentile scores on the MCDI, and demonstrated a rate of word learning that was faster than rates found in the literature. Cross-situational statistically based word learning intervention has the potential to improve vocabulary learning in late-talking toddlers. Limitations on interpretation are also discussed. Readers will describe what cross-situational learning is and how it might apply to treatment. They will identify how including lexical and contextual variability in a word learning intervention for toddlers affected treatment outcomes. They will also recognize evidence of improved rate of vocabulary learning following treatment. Copyright © 2014 Elsevier Inc. All rights reserved.

  14. Situation analysis of community pharmacy owners in Lebanon

    Directory of Open Access Journals (Sweden)

    Hallit S

    2017-03-01

    Full Text Available Objective: To evaluate the current community pharmacists’ interventions and job satisfaction, secondary to the alteration in the financial rewards. Methods: A cross-sectional study was carried out, using a proportionate random sample of Lebanese community pharmacy owners from all districts of Lebanon. Results: Out of 1618 distributed questionnaires, 1465 (90.5% were collected back from pharmacy owners. Our study results showed that the monthly sales and profit decreased significantly in the last decade as well as the number of loyal customers (p<0.001 for all. The rent, the total assistant pharmacists’ and employees’ salaries, income taxes, municipality fees, the total bills (electricity, water, cleaning, security and the disposal of expired products per year significantly increased during the last 10 years (p<0.001. 95% of the owners said they cannot afford to hire any more pharmacists while 45% said they cannot afford buying software for their pharmacies. Finally, 89% of these owners admitted that their situation was better 10 years ago compared to nowadays. Conclusion: Most Lebanese community pharmacists are not financially satisfied; their financial situation deteriorated in the last decade. The ministry of Health along with the Order of Pharmacists in Lebanon should cooperate together to resolve this problem since they are two entities responsible for the patient’s health.

  15. Numerical analysis of free surface instabilities in the IFMIF lithium target

    International Nuclear Information System (INIS)

    Gordeev, S.; Heinzel, V.; Moeslang, A.

    2007-01-01

    The International Fusion Materials Facility (IFMIF) facility uses a high speed (10-20 m/s) Lithium (Li) jet flow as a target for two 40 MeV/125 mA deuteron beams. The major function of the Li target is to provide a stable Li jet for the production of an intense neutron flux. For the understanding the lithium jet behaviour and elimination of the free-surface flow instabilities a detailed analysis of the Li jet flow is necessary. Different kinds of instability mechanisms in the liquid jet flow have been evaluated and classified based on analytical and experimental data. Numerical investigations of the target free surface flow have been performed. Previous numerical investigations have shown in principle the suitability of CFD code Star- CD for the simulation of the Li-target flow. The main objective of this study is detailed numerical analysis of instabilities in the Li-jet flow caused by boundary layer relaxation near the nozzle exit, transition to the turbulence flow and back wall curvature. A number of CFD models are developed to investigate the formation of instabilities on the target surface. Turbulence models are validated on the experimental data. Experimental observations have shown that the change of the nozzle geometry at the outlet such as a slight divergence of the nozzle surfaces or nozzle edge defects causes the flow separation and occurrence of longitudinal periodic structures on the free surface with an amplitude up to 5 mm. Target surface fluctuations of this magnitude can lead to the penetration of the deuteron beam in the target structure and cause the local overheating of the back plat. Analysis of large instabilities in the Li-target flow combined with the heat distribution in lithium depending on the free surface shape is performed in this study. (orig.)

  16. [Segment analysis of the target market of physiotherapeutic services].

    Science.gov (United States)

    Babaskin, D V

    2010-01-01

    The objective of the present study was to demonstrate the possibilities to analyse selected segments of the target market of physiotherapeutic services provided by medical and preventive-facilities of two major types. The main features of a target segment, such as provision of therapeutic massage, are illustrated in terms of two characteristics, namely attractiveness to the users and the ability of a given medical facility to satisfy their requirements. Based on the analysis of portfolio of the available target segments the most promising ones (winner segments) were selected for further marketing studies. This choice does not exclude the possibility of involvement of other segments of medical services in marketing activities.

  17. Transmutation technology development; thermal hydraulic power analysis and structure analysis of the HYPER target beam window

    Energy Technology Data Exchange (ETDEWEB)

    Choi, J. H.; Ju, E. S.; Song, M. K.; Jeon, Y. Z. [Gyeongsang National University, Jinju (Korea)

    2002-03-01

    A thermal hydraulic power analysis, a structure analysis and optimization computation for some design factor for the design of spallation target suitable for HYPER with 1000 MW thermal power in this study was performed. Heat generation formula was used which was evaluated recently based on the LAHET code, mainly to find the maximum beam current under given computation conditions. Thermal hydraulic power of HYPER target system was calculated using FLUENT code, structure conducted by inputting the data into ANSYS. On the temp of beam windows and the pressure distribution calculated using FLUENT. Data transformation program was composed apply the data calculated using FLUENT being commercial CFD code and ANSYS being FEM code for CFX structure analysis. A basic study was conducted on various singular target to obtain fundamental data on the shape for optimum target design. A thermal hydraulic power analysis and structure analysis were conducted on the shapes of parabolic, uniform, scanning beams to choose the optimum shape of beam current analysis was done according to some turbulent model to simulate the real flow. To evaluate the reliability of numerical analysis result, benchmarking of FLUENT code reformed at SNU and Korea Advanced Institute of Science and Technology and it was compared to CFX in the possession of Korea Atomic Energy Research Institute and evaluated. Reliable deviation was observed in the results calculated using FLUENT code, but temperature deviation of about 200 .deg. C was observed in the result from CFX analysis at optimum design condition. Several benchmarking were performed on the basis of numerical analysis concerning conventional HYPER. It was possible to allow a beam arrests of 17.3 mA in the case of the {phi} 350 mm parabolic beam suggested to the optimum in nuclear transmutation when stress equivalent to VON-MISES was calculated to be 140 MPa. 29 refs., 109 figs. (Author)

  18. Situated Transgressiveness

    DEFF Research Database (Denmark)

    Muhr, Sara Louise; Sullivan, Katie Rose; Rich, Craig

    2016-01-01

    conversations within queer theory, transgender and organization studies by highlighting how situated contexts mediate the political potential of queer bodies at work. By developing the concept ‘situated transgressiveness’, this article challenges notions of transgender as a stable, ideal disruptive category......This study investigates the lived experience of one transwoman, Claire, a public advocate and a manager with client services responsibilities. We examine Claire's story in order to discuss how situated contexts, such as different roles, locales and interactions, shape the way she experiences...

  19. Situated learning and interacting with/through technologies

    DEFF Research Database (Denmark)

    Raudaskoski, Pirkko Liisa

    2006-01-01

    There is a growing interest within social and humanistic sciences towards understanding practice theoretically and analytically. Lave and Wenger’s concept “situated learning” describes the process of newcomers moving toward full participation in a community. Wenger later refined his approach in h...... practices. The interdisciplinary interaction analysis (IA) is suggested as the best way to study the various aspects of situated learning in technology-intensive interactions.......There is a growing interest within social and humanistic sciences towards understanding practice theoretically and analytically. Lave and Wenger’s concept “situated learning” describes the process of newcomers moving toward full participation in a community. Wenger later refined his approach in his...... book ‘Communities of practice: Learning, meaning and identity’. Situated learning is equalled with social order: instead of understanding learning as a separate practice from everyday life, learning is seen as a more mundane phenomenon. It is sometimes difficult to operationalize Lave and Wenger...

  20. Diagnostic orientation in control of disturbance situations

    International Nuclear Information System (INIS)

    Hukki, K.; Norros, L.

    1993-01-01

    The object of the study is diagnostic judgement in the control of dynamic processes. The starting point was the known difficulty process operators have in utilizing knowledge of process dynamics in disturbance situations that require both diagnostic and prognostic actions. A model of the diagnostic judgement process as a construction of coherent interpretation of the situation is outlined, and comprehensive data from simulated disturbance handling by 6 crews of a PWR type nuclear power plant was analysed. The phase of analysis included evaluation of the adequacy of task performance, utilization of available process information, and evaluation of the interpretation of disturbance situations. The results suggest that a functional orientation towards task performance allows a more coherent and comprehensive interpretation of the situation and more adequate task performance. Coherence of interpretation seems to be reflected in a higher subjective certainty compared with crews with an incoherent interpretation. (author). 15 refs, 2 figs, 2 tabs

  1. Continuous measures of situation awareness and workload

    International Nuclear Information System (INIS)

    Droeivoldsmo, Asgeir; Skraaning, Gyrd jr.; Sverrbo, Mona; Dalen, Joergen; Grimstad, Tone; Andresen, Gisle

    1998-03-01

    This report presents methods for continuous measures for Situation Awareness and Workload. The objective has been to identify, develop and test the new measures, and compare them to instruments that require interruptions of scenarios. The new measures are: (1) the Visual Indicator of Situation Awareness (VISA); where Situation Awareness is scored from predefined areas of visual interest critical for solving scenarios. Visual monitoring of areas was recorded by eye-movement tracking. (2) Workload scores reflected by Extended Dwell Time (EDT) and the operator Activity Level. EDT was calculated from eye-movement data files, and the activity level was estimated from simulator logs. Using experimental data from the 1996 CASH NRC Alarm study and the 1997 Human Error Analysis Project/ Human-Centred Automation study, the new measurement techniques have been tested and evaluated on a preliminary basis. The results showed promising relationships between the new continuous measures of situation awareness and workload, and established instruments based upon scenario interruptions. (author)

  2. Dynamic Chaos, Conflicts in the Greater Middle East and Global Governance Mechanisms in the XXI Century (Proceedings of PFUR's Expert Seminars and Situational Analysis

    Directory of Open Access Journals (Sweden)

    Denis Andreevich Degterev

    2015-12-01

    Full Text Available The article summarizes the experience of methodological expert seminars and case studies of international conflict of the Department of Theory and History of International Relations of the Faculty of Humanities and Social Sciences at Peoples’ Friendship University of Russia. The background and the main stages of elaboration of PFUR’s integrated multidisciplinary methodology of situation analysis of international conflicts are described. The evolution of methodological approaches to conflict analysis used in the expert community, from classical methods, including the method of analytic hierarchy by T. Saati to the nonlinear dynamics of the processes of regional development and the perception of the international system as a non-equilibrium system are shown, as well as possibilities of use of approaches of the natural sciences (theory of complex systems in the modeling of international relations. Particular attention is paid to the results of PFUR's situational analysis 2015 “Greater Middle East: twenty years later (1994-2014”. The authors show us the methodology of situation analysis in details, including the matrix approach to the distribution of research topics and the method of ranking research tasks by difficulty level between different categories of participants (students, masters, postgraduate students, teachers. A special focus is made on proceedings of leading orientalists from Russia (Institute of Oriental Studies, Russian Academy of Science and foreign countries (Austria, UK. The directions of further improvement of PFUR's methods of situational analysis are provided.

  3. Thermal analysis of Ti drive-in target for D-D neutron generation

    International Nuclear Information System (INIS)

    Jung, N.S.; Kim, I.J.; Kim, S.J.; Choi, H.D.

    2008-01-01

    Full text: Thermal analysis was performed for a Ti drive-in target of a D-D neutron generator. Numerical calculation was the only feasible way to obtain the information of the target temperature, since it was very difficult to measure the target temperature during neutron generation due to high voltage being applied to the target. Computational fluid dynamics code CFX-5 was used in this study. In order to define the heat flux term for the thermal analysis, the current profile of the ion beam was measured. The one-dimensional, integrated current profile was measured by using a single slit and a Faraday cup. The measured current profile was transformed into the axially symmetric two-dimensional distribution function by using the Abel inversion, which had the two-dimensional Gaussian function shape. Temperature distribution in the target was calculated at the operating condition. The influence of operational parameters like the ion beam energy, current, coolant mass flow rate and coolant inlet temperature on the target temperature was investigated

  4. Employment situation and risk of death among middle-aged Japanese women.

    Science.gov (United States)

    Honjo, Kaori; Iso, Hiroyasu; Ikeda, Ai; Fujino, Yoshihisa; Tamakoshi, Akiko

    2015-10-01

    Few studies have examined the health effects of employment situation among women, taking social and economic conditions into consideration. The objective of this research was to investigate the association of employment situation (full-time or part-time employee and self-employed) with mortality risk in women over a 20-year follow-up period. Additionally, we examined whether the association between employment situation and mortality in women differed by education level and marital status. We investigated the association of employment situation with mortality among 16,692 women aged 40-59 years enrolled in the Japan Collaborative Cohort Study. Multivariate HRs and 95% CIs for total deaths by employment situation were calculated after adjustment for age, disease history, residential area, education level, marital status and number of children. We also conducted subgroup analysis by education level and marital status. Multivariate HRs for mortality of part-time employees and self-employed workers were 1.48 (95% CI, 1.25 to 1.75) and 1.44 (95% CI, 1.21 to 1.72), respectively, with reference to women working full-time. Subgroup analysis by education level indicated that health effects in women according to employment situation were likely to be more evident in the low education-level group. Subgroup analysis by marital status indicated that this factor also affected the association between employment situation and risk of death. Among middle-aged Japanese women, employment situation was associated with mortality risk. Health effects were likely to differ by household structure and socioeconomic conditions. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  5. Analysis of the Neutron Generator and Target for the LSDTS System

    Energy Technology Data Exchange (ETDEWEB)

    Park, Chang Je; Lee, Yong Deok; Song, Jae Hoon; Song, Kee Chan [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2008-11-15

    A preliminary analysis was performed based on the literatures and the patents for the neutron generators and targets for the lead slowing down time spectrometer (LSDTS) system. It was found that local neutron generator did not exhibit enough neutron intensity such as 1E+12 n/s, which is a minimum requirement for the LSDTS system to overcome curium backgrounds. However, a neutron generator implemented with an electron accelerator may provide a higher intensity around 1E+13 n/s and it is required to investigate further including a detail analysis. In addition to the neutron generator, a study on target was performed with the Monte Carlo simulation. In the study, an optimal design of target was suggested to provide a high neutron yield and a better thermal resistance. The suggested target consists several cylindrical plates with a certain cooling gap, which have increasing thickness and increasing radius.

  6. The electricity market. Situation and predictions 2018 - Sectoral and competitive analysis

    International Nuclear Information System (INIS)

    2017-01-01

    This document comprises two reports. A first one, published and updated three times a year, and a second one which is a yearly publication. The first one, based on an analysis of market perspectives and of actor strategies, proposes a synthesis on the consequences of the evolution of the economic environment, on major trends noticed for the electric power sector, and on predictable evolutions. It proposes the most recent data regarding the activities of about 200 firms belonging to the power sector (notably in terms of turnover and of electric power consumption). It highlights recent events for companies of the sector: takeovers, investments, restructuring, introduction of new products, and so on. It proposes a sector-based dashboard which contains all the critical figures useful to analyse the sector situation (activity determining factors, key figures for the sector and its environment). The annual report proposes a presentation of the sector and of the determining factors of its activity, an analysis of the activity evolution (trends, indicators like turnover, electric power consumption and production, prices and regulated tariffs, power imports and exports), a presentation of financial performance of electricity producers, a description of the sector economic structure (evolution of the economic tissue, analysis of structural characteristics), and a presentation of actors and of the competitive landscape (ranking and positioning of electric power providers and producers, market shares, identity sheets of the main actors, highlights, and ranking of the main companies in terms of turnover and of financial performance)

  7. Analysis and decision making method for radiation accident situation

    International Nuclear Information System (INIS)

    Jammet, H.; Hamard, J.

    1975-01-01

    Decisions on the application of countermeasures for accident situations must take into account the cost of these countermeasures and the feasibility of reducing the exposure. A contribution to the solution of this problem, rested on the application of the principle of choice rationalization and optimization of decision making method, is presented [fr

  8. Radioecological situation at the 'Karazhyra' coal deposit

    International Nuclear Information System (INIS)

    Panin, M.S.; Artamonova, E.N.; Medvedev, P.P.

    2005-01-01

    This paper presents results of the current radiological situation in ground water within the 'Karazhyra' coal deposit. The fulfilled studies have been revealed groundwater contamination with wide variety of anthropogenic radionuclides. Analysis of the current level of radionuclide activity in ground water of the coal deposit allows considering the radionuclides to be not hazardous. Results of many-year observations gave a possibility to quantitatively describe radionuclide content in ground water as well as predict development of water-bearing horizon radiation situation for the near future. (author)

  9. Is there a Competition between Functional and Situational Affordances during Action Initiation with Everyday Tools?

    Directory of Open Access Journals (Sweden)

    Kévin Roche

    2017-06-01

    Full Text Available Most studies of human-tool interactions focus on the typical use of a tool (e.g., cutting in the case of a knife. However, little is known about situations requiring atypical tool use (e.g., using a knife to tighten a screw. The present study focused on a selection of atypical uses of everyday tools which might be in conflict with their typical use. Our objective was to study how tool function influences the selection of the relevant action. In Experiment 1, which involved visuomotor priming, two everyday tools (a knife and a screwdriver and two neutral tools (two bars, with no strong functional affordance were used as primes and targets. Participants had to use the target with the appropriate box (indicated by the color that allowed to make an action. Longer initiation times were observed when the prime was an everyday tool, irrespective of the nature of the target. We therefore observed a conflict between functional and situational affordances. To investigate whether the priming effect is caused by the task-irrelevance of the prime, we asked the participants in Experiment 2 to perform an action associated with the prime. The results showed longer initiation times only when the prime and target were everyday tools, irrespective of their precise nature. This suggests that activation of the typical use of a tool might not be fully automatic but flexible depending on the situation.

  10. Information systems for mental health in six low and middle income countries: cross country situation analysis.

    Science.gov (United States)

    Upadhaya, Nawaraj; Jordans, Mark J D; Abdulmalik, Jibril; Ahuja, Shalini; Alem, Atalay; Hanlon, Charlotte; Kigozi, Fred; Kizza, Dorothy; Lund, Crick; Semrau, Maya; Shidhaye, Rahul; Thornicroft, Graham; Komproe, Ivan H; Gureje, Oye

    2016-01-01

    Research on information systems for mental health in low and middle income countries (LMICs) is scarce. As a result, there is a lack of reliable information on mental health service needs, treatment coverage and the quality of services provided. With the aim of informing the development and implementation of a mental health information sub-system that includes reliable and measurable indicators on mental health within the Health Management Information Systems (HMIS), a cross-country situation analysis of HMIS was conducted in six LMICs (Ethiopia, India, Nepal, Nigeria, South Africa and Uganda), participating in the 'Emerging mental health systems in low and middle income countries' (Emerald) research programme. A situation analysis tool was developed to obtain and chart information from documents in the public domain. In circumstances when information was inadequate, key government officials were contacted to verify the data collected. In this paper we compare the baseline policy context, human resources situation as well as the processes and mechanisms of collecting, verifying, reporting and disseminating mental health related HMIS data. The findings suggest that countries face substantial policy, human resource and health governance challenges for mental health HMIS, many of which are common across sites. In particular, the specific policies and plans for the governance and implementation of mental health data collection, reporting and dissemination are absent. Across sites there is inadequate infrastructure, few HMIS experts, and inadequate technical support and supervision to junior staff, particularly in the area of mental health. Nonetheless there are also strengths in existing HMIS where a few mental health morbidity, mortality, and system level indicators are collected and reported. Our study indicates the need for greater technical and resources input to strengthen routine HMIS and develop standardized HMIS indicators for mental health, focusing in

  11. Mental health in primary health care in a rural district of Cambodia: a situational analysis.

    Science.gov (United States)

    Olofsson, Sofia; Sebastian, Miguel San; Jegannathan, Bhoomikumar

    2018-01-01

    While mental and substance use disorders are common worldwide, the treatment gap is enormous in low and middle income countries. Primary health care is considered to be the most important way for people to get mental health care. Cambodia is a country with a long history of war and has poor mental health and limited resources for care. The aim of this study was to conduct a situational analysis of the mental health services in the rural district of Lvea Em, Kandal Province, Cambodia. A cross-sectional situational analysis was done to understand the mental health situation in Lvea Em District comparing it with the national one. The Programme for improving mental health care (PRIME) tool was used to collect systematic information about mental health care from 14 key informants in Cambodia. In addition, a separate questionnaire based on the PRIME tool was developed for the district health care centres (12 respondents). Ethical approval was obtained from the National Ethics Committee for Health Research in Cambodia. Mental health care is limited both in Lvea Em District and the country. Though national documents containing guidelines for mental health care exist, the resources available and health care infrastructure are below what is recommended. There is no budget allocated for mental health in the district; there are no mental health specialists and the mental health training of health care workers is insufficient. Based on the limited knowledge from the respondents in the district, mental health disorders do exist but no documentation of these patients is available. Respondents discussed how community aspects such as culture, history and religion were related to mental health. Though there have been improvements in understanding mental health, discrimination and abuse against people with mental health disorders seems still to be present. There are very limited mental health care services with hardly any budget allocated to them in Lvea Em District and Cambodia

  12. Analysis of Deregulated microRNAs and Their Target Genes in Gastric Cancer.

    Directory of Open Access Journals (Sweden)

    Simonas Juzėnas

    Full Text Available MicroRNAs (miRNAs are widely studied non-coding RNAs that modulate gene expression. MiRNAs are deregulated in different tumors including gastric cancer (GC and have potential diagnostic and prognostic implications. The aim of our study was to determine miRNA profile in GC tissues, followed by evaluation of deregulated miRNAs in plasma of GC patients. Using available databases and bioinformatics methods we also aimed to evaluate potential target genes of confirmed differentially expressed miRNA and validate these findings in GC tissues.The study included 51 GC patients and 51 controls. Initially, we screened miRNA expression profile in 13 tissue samples of GC and 12 normal gastric tissues with TaqMan low density array (TLDA. In the second stage, differentially expressed miRNAs were validated in a replication cohort using qRT-PCR in tissue and plasma samples. Subsequently, we analyzed potential target genes of deregulated miRNAs using bioinformatics approach, determined their expression in GC tissues and performed correlation analysis with targeting miRNAs.Profiling with TLDA revealed 15 deregulated miRNAs in GC tissues compared to normal gastric mucosa. Replication analysis confirmed that miR-148a-3p, miR-204-5p, miR-223-3p and miR-375 were consistently deregulated in GC tissues. Analysis of GC patients' plasma samples showed significant down-regulation of miR-148a-3p, miR-375 and up-regulation of miR-223-3p compared to healthy subjects. Further, using bioinformatic tools we identified targets of replicated miRNAs and performed disease-associated gene enrichment analysis. Ultimately, we evaluated potential target gene BCL2 and DNMT3B expression by qRT-PCR in GC tissue, which correlated with targeting miRNA expression.Our study revealed miRNA profile in GC tissues and showed that miR-148a-3p, miR-223-3p and miR-375 are deregulated in GC plasma samples, but these circulating miRNAs showed relatively weak diagnostic performance as sole biomarkers

  13. Mechanisms and situations of anterior cruciate ligament injuries in professional male soccer players: a YouTube-based video analysis.

    Science.gov (United States)

    Grassi, Alberto; Smiley, Stephen Paul; Roberti di Sarsina, Tommaso; Signorelli, Cecilia; Marcheggiani Muccioli, Giulio Maria; Bondi, Alice; Romagnoli, Matteo; Agostini, Alessandra; Zaffagnini, Stefano

    2017-10-01

    Soccer is considered the most popular sport in the world concerning both audience and athlete participation, and the incidence of ACL injury in this sport is high. The understanding of injury situations and mechanisms could be useful as substratum for preventive actions. To conduct a video analysis evaluating the situations and mechanisms of ACL injury in a homogeneous population of professional male soccer players, through a search entirely performed on the YouTube.com Web site focusing on the most recent years. A video analysis was conducted obtaining videos of ACL injury in professional male soccer players from the Web site YouTube. Details regarding injured players, events and situations were obtained. The mechanism of injury was defined on the basis of the action, duel type, contact or non-contact injury, and on the hip, knee and foot position. Thirty-four videos were analyzed, mostly from the 2014-2015 season. Injuries occurred mostly in the first 9 min of the match (26%), in the penalty area (32%) or near the side-lines (44%), and in non-rainy conditions (97%). Non-contact injuries occurred in 44% of cases, while indirect injuries occurred in 65%, mostly during pressing, dribbling or tackling. The most recurrent mechanism was with an abducted and flexed hip, with knee at first degrees of flexion and under valgus stress. Through a YouTube-based video analysis, it was possible to delineate recurrent temporal, spatial and mechanical characteristics of ACL injury in male professional soccer players. Level IV, case series.

  14. Integrative analysis to select cancer candidate biomarkers to targeted validation

    Science.gov (United States)

    Heberle, Henry; Domingues, Romênia R.; Granato, Daniela C.; Yokoo, Sami; Canevarolo, Rafael R.; Winck, Flavia V.; Ribeiro, Ana Carolina P.; Brandão, Thaís Bianca; Filgueiras, Paulo R.; Cruz, Karen S. P.; Barbuto, José Alexandre; Poppi, Ronei J.; Minghim, Rosane; Telles, Guilherme P.; Fonseca, Felipe Paiva; Fox, Jay W.; Santos-Silva, Alan R.; Coletta, Ricardo D.; Sherman, Nicholas E.; Paes Leme, Adriana F.

    2015-01-01

    Targeted proteomics has flourished as the method of choice for prospecting for and validating potential candidate biomarkers in many diseases. However, challenges still remain due to the lack of standardized routines that can prioritize a limited number of proteins to be further validated in human samples. To help researchers identify candidate biomarkers that best characterize their samples under study, a well-designed integrative analysis pipeline, comprising MS-based discovery, feature selection methods, clustering techniques, bioinformatic analyses and targeted approaches was performed using discovery-based proteomic data from the secretomes of three classes of human cell lines (carcinoma, melanoma and non-cancerous). Three feature selection algorithms, namely, Beta-binomial, Nearest Shrunken Centroids (NSC), and Support Vector Machine-Recursive Features Elimination (SVM-RFE), indicated a panel of 137 candidate biomarkers for carcinoma and 271 for melanoma, which were differentially abundant between the tumor classes. We further tested the strength of the pipeline in selecting candidate biomarkers by immunoblotting, human tissue microarrays, label-free targeted MS and functional experiments. In conclusion, the proposed integrative analysis was able to pre-qualify and prioritize candidate biomarkers from discovery-based proteomics to targeted MS. PMID:26540631

  15. Emergency situations

    International Nuclear Information System (INIS)

    2007-01-01

    The nuclear activities are exercised so as to prevent the accidents. They are subjected to a rule whom application is controlled by the Asn. The risk of grave accident is so limited to a very low level of probability. He cannot be however completely pushed aside. The expression ' radiological emergency situation ' indicates a situation which ensues from an incident or of an accident risking to lead to an emission of radioactive materials or a level of radioactivity susceptible to strike a blow at the public health. The term ' nuclear crisis ' is used for the events which can lead to a radiological emergency situation on a nuclear basic installation or during a transport of radioactive materials. The preparation and the management of emergency situations, that they are of natural, accidental or terrorist origin, became a major concern of our society. We propose you of to know more about it in this file. (N.C.)

  16. The fabrication of steam generators. Situation and predictions 2017 and 2018 - Sectoral and competitive analysis

    International Nuclear Information System (INIS)

    2017-01-01

    This report proposes a situational analysis and a discussion of trends for the sector of fabrication of steam generators. It also proposes predictions for 2017 and 2018, and all important figures useful to analyse the sector and its market. It discusses positions of the different actors, and the competitive game between them. Key events in firms life are indicated, and key development axes are identified. The report also proposes a ranking, a presentation of financial performance, and synthetic sheets for 55 leader firms of the sector

  17. Nuclear Security: Target Analysis-rev

    Energy Technology Data Exchange (ETDEWEB)

    Singh, Surinder Paul [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Gibbs, Philip W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Bultz, Garl A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2014-03-01

    The objectives of this presentation are to understand target identification, including roll-up and protracted theft; evaluate target identification in the SNRI; recognize the target characteristics and consequence levels; and understand graded safeguards.

  18. Performance Analysis of Sensor Systems for Space Situational Awareness

    Science.gov (United States)

    Choi, Eun-Jung; Cho, Sungki; Jo, Jung Hyun; Park, Jang-Hyun; Chung, Taejin; Park, Jaewoo; Jeon, Hocheol; Yun, Ami; Lee, Yonghui

    2017-12-01

    With increased human activity in space, the risk of re-entry and collision between space objects is constantly increasing. Hence, the need for space situational awareness (SSA) programs has been acknowledged by many experienced space agencies. Optical and radar sensors, which enable the surveillance and tracking of space objects, are the most important technical components of SSA systems. In particular, combinations of radar systems and optical sensor networks play an outstanding role in SSA programs. At present, Korea operates the optical wide field patrol network (OWL-Net), the only optical system for tracking space objects. However, due to their dependence on weather conditions and observation time, it is not reasonable to use optical systems alone for SSA initiatives, as they have limited operational availability. Therefore, the strategies for developing radar systems should be considered for an efficient SSA system using currently available technology. The purpose of this paper is to analyze the performance of a radar system in detecting and tracking space objects. With the radar system investigated, the minimum sensitivity is defined as detection of a 1-m2 radar cross section (RCS) at an altitude of 2,000 km, with operating frequencies in the L, S, C, X or Ku-band. The results of power budget analysis showed that the maximum detection range of 2,000 km, which includes the low earth orbit (LEO) environment, can be achieved with a transmission power of 900 kW, transmit and receive antenna gains of 40 dB and 43 dB, respectively, a pulse width of 2 ms, and a signal processing gain of 13.3 dB, at a frequency of 1.3 GHz. We defined the key parameters of the radar following a performance analysis of the system. This research can thus provide guidelines for the conceptual design of radar systems for national SSA initiatives.

  19. Indicator based sustainability analysis of future energy situation of Santiago de Chile

    OpenAIRE

    Stelzer, Volker; Quintero, Adriana; Vargas, Luis; Paredes, Gonzalo; Simon, Sonja; Nienhaus, Kristina; Kopfmüller, Jürgen

    2014-01-01

    Up to now, the Chilean Energy system has fulfilled the energy needs of Santiago de Chile considerably well. However, development trends of the current system impose significant future risks on the energy system. A detailed sustainability analysis of the energy sector of the Metropolitan Region of Santiago de Chile was conducted, using selected energy indicators and a distance-to-target approach. Risks for the sustainable development of the energy sector are detected, such...

  20. Victims of educator-targeted bullying: a qualitative study

    Directory of Open Access Journals (Sweden)

    Corene de Wet

    2010-01-01

    Full Text Available I report on findings emanating from in-depth personal interviews with victims of educator-targeted bullying (ETB. Qualitative content analysis was used to analyse the narratives. The findings indicate that the victims of ETB were exposed repeatedly over time to verbal, non-verbal, psychological, and physical abuse during and after school hours. ETB had a negative influence on the victims' private lives, as well as on teaching and on learning. Lastly, I found that ETB may lead to a breakdown of relations between victims and the bullies' parents and the members of the community in which schools are situated.

  1. Mapping the Strategic Thinking of Public Relations Managers in a Crisis Situation: An Illustrative Example Using Conjoint Analysis.

    Science.gov (United States)

    Bronn, Peggy Simcic; Olson, Erik L.

    1999-01-01

    Illustrates the operationalization of the conjoint analysis multivariate technique for the study of the public relations function within strategic decision making in a crisis situation. Finds that what the theory describes as the strategic way of handling a crisis is also the way each of the managers who were evaluated would prefer to conduct…

  2. Meta-Analysis of PECS with Individuals with ASD: Investigation of Targeted versus Non-Targeted Outcomes, Participant Characteristics, and Implementation Phase

    Science.gov (United States)

    Ganz, Jennifer B.; Davis, John L.; Lund, Emily M.; Goodwyn, Fara D.; Simpson, Richard L.

    2012-01-01

    The Picture Exchange Communication System (PECS) is a widely used picture/icon aided augmentative communication system designed for learners with autism and other developmental disorders. This meta-analysis analyzes the extant empirical literature for PECS relative to targeted (functional communication) and non-targeted concomitant outcomes…

  3. The situation-specific theory of pain experience for Asian American cancer patients.

    Science.gov (United States)

    Im, Eun-Ok

    2008-01-01

    Studies have indicated the need for theories that explain and target ethnic-specific cancer pain experiences, including those of Asian Americans. In this article, I present a situation-specific theory that explains the unique cancer pain experience of Asian Americans. Unlike other existing theories, this situation-specific theory was developed on the basis of evidence, including a systematic literature review and research findings, making it comprehensive and highly applicable to research and practice with Asian American patients with cancer. Thus, this theory would strengthen the interconnections among theory, evidence, and practice in pain management for Asian American cancer patients.

  4. Statistical analysis of target motion in gated lung stereotactic body radiation therapy

    International Nuclear Information System (INIS)

    Zhao Bo; Yang Yong; Li Tianfang; Li Xiang; Heron, Dwight E; Huq, M Saiful

    2011-01-01

    An external surrogate-based respiratory gating technique is a useful method to reduce target margins for the treatment of a moving lung tumor. The success of this technique relies on a good correlation between the motion of the external markers and the internal tumor as well as the repeatability of the respiratory motion. In gated lung stereotactic body radiation therapy (SBRT), the treatment time for each fraction could exceed 30 min due to large fractional dose. Tumor motion may experience pattern changes such as baseline shift during such extended treatment time. The purpose of this study is to analyze tumor motion traces in actual treatment situations and to evaluate the effect of the target baseline shift in gated lung SBRT treatment. Real-time motion data for both the external markers and tumors from 51 lung SBRT treatments with Cyberknife Synchrony technology were analyzed in this study. The treatment time is typically greater than 30 min. The baseline shift was calculated with a rolling average window equivalent to ∼20 s and subtracted from that at the beginning. The magnitude of the baseline shift and its relationship with treatment time were investigated. Phase gating simulation was retrospectively performed on 12 carefully selected treatments with respiratory amplitude larger than 5 mm and regular phases. A customized gating window was defined for each individual treatment. It was found that the baseline shifts are specific to each patient and each fraction. Statistical analysis revealed that more than 69% treatments exhibited increased baseline shifts with the lapse of treatment time. The magnitude of the baseline shift could reach 5.3 mm during a 30 min treatment. Gating simulation showed that tumor excursion was caused mainly by the uncertainties in phase gating simulation and baseline shift, the latter being the primary factor. With a 5 mm gating window, 2 out of 12 treatments in the study group showed significant tumor excursion. Baseline shifts

  5. Current situation and future usage of anticancer drug databases.

    Science.gov (United States)

    Wang, Hongzhi; Yin, Yuanyuan; Wang, Peiqi; Xiong, Chenyu; Huang, Lingyu; Li, Sijia; Li, Xinyi; Fu, Leilei

    2016-07-01

    Cancer is a deadly disease with increasing incidence and mortality rates and affects the life quality of millions of people per year. The past 15 years have witnessed the rapid development of targeted therapy for cancer treatment, with numerous anticancer drugs, drug targets and related gene mutations been identified. The demand for better anticancer drugs and the advances in database technologies have propelled the development of databases related to anticancer drugs. These databases provide systematic collections of integrative information either directly on anticancer drugs or on a specific type of anticancer drugs with their own emphases on different aspects, such as drug-target interactions, the relationship between mutations in drug targets and drug resistance/sensitivity, drug-drug interactions, natural products with anticancer activity, anticancer peptides, synthetic lethality pairs and histone deacetylase inhibitors. We focus on a holistic view of the current situation and future usage of databases related to anticancer drugs and further discuss their strengths and weaknesses, in the hope of facilitating the discovery of new anticancer drugs with better clinical outcomes.

  6. Recognition of risk situations based on endoscopic instrument tracking and knowledge based situation modeling

    Science.gov (United States)

    Speidel, Stefanie; Sudra, Gunther; Senemaud, Julien; Drentschew, Maximilian; Müller-Stich, Beat Peter; Gutt, Carsten; Dillmann, Rüdiger

    2008-03-01

    Minimally invasive surgery has gained significantly in importance over the last decade due to the numerous advantages on patient-side. The surgeon has to adapt special operation-techniques and deal with difficulties like the complex hand-eye coordination, limited field of view and restricted mobility. To alleviate these constraints we propose to enhance the surgeon's capabilities by providing a context-aware assistance using augmented reality (AR) techniques. In order to generate a context-aware assistance it is necessary to recognize the current state of the intervention using intraoperatively gained sensor data and a model of the surgical intervention. In this paper we present the recognition of risk situations, the system warns the surgeon if an instrument gets too close to a risk structure. The context-aware assistance system starts with an image-based analysis to retrieve information from the endoscopic images. This information is classified and a semantic description is generated. The description is used to recognize the current state and launch an appropriate AR visualization. In detail we present an automatic vision-based instrument tracking to obtain the positions of the instruments. Situation recognition is performed using a knowledge representation based on a description logic system. Two augmented reality visualization programs are realized to warn the surgeon if a risk situation occurs.

  7. Situated Formative Feedback

    DEFF Research Database (Denmark)

    Lukassen, Niels Bech; Wahl, Christian; Sorensen, Elsebeth Korsgaard

    refer to this type of feedback as, Situated Formative Feedback (SFF). As a basis for exploring, identifying and discussing relevant aspects of SFF the paper analyses qualitative data from a Moodle dialogue. Data are embedded in the qualitative analytic program Nvivo and are analysed with a system...... theoretical textual analysis method. Asynchronous written dialogue from an online master’s course at Aalborg University forms the empirical basis of the study. The findings suggests in general that students play an essential role in SFF and that students and educators are equal in the COP, but holds different...

  8. Detector evaluation for improved situational awareness: Receiver operator characteristic curve based

    NARCIS (Netherlands)

    Wuijckhuijse, A.L. van; Nieuwenhuizen, M.S.

    2016-01-01

    In military and civilian operations good situational awareness is a prerequisite to make proper decisions. The situational awareness is among others based upon intelligence, threat analysis and detection, altogether element of the so-called DIM (detection, identification, monitoring) system. In case

  9. Analysis on present radon ventilation situation of Chinese uranium mines

    International Nuclear Information System (INIS)

    Li Xianjie; Hu Penghua

    2010-01-01

    Mine Ventilation is the most important way in lowering radon of uranium mines. At present, radon and radon daughter concentration of underground air is 3∼5 times higher than any other air concentration of foreign uranium mines, as the same input for Protective Ventilation between Chinese uranium mines with compaction methodology and international advanced uranium mines. In this passage, through the analysis of Ventilation Radon Reduction status in Chinese uranium mines and the comparison of advantages and shortcomings between variety of ventilation and radon reduction, it illuminated the reasons of higher radon and radon daughter concentration in Chinese uranium mines and put forward some problems in three aspects, which are Ventilation Radon Reduction Theory, Ventilation Radon Reduction Measures and Ventilation Management. And to above problems, this passage put forward some proposals and measures about some aspects, such as strengthen examination and verification and monitoring practical situation, making clear ventilation plan, in according to mining sequence strictly, training Ventilation technician forcefully, enhance Ventilation System management, development of Ventilation Radon Reduction technology research in uranium mines and carrying out ventilation equipments as soon as possible in further and so on. (authors)

  10. Emergency situation in a medical cyclotron facility

    International Nuclear Information System (INIS)

    Kumar, Rajeev; Bhat, M.K.; Singh, D.K.; Pthania, B.S.; Pandit, A.G.; Jacob, M.J.

    2010-01-01

    Full text: Medical cyclotron is a particle accelerator used in producing short lived radioisotopes such as 18 F, 11 C, 15 O, 13 N, 18 F-2 gas etc. Positron Emission Tomography (PET) is a nuclear imaging modality that has rapidly gained favour. 18 F-FDG is the most widely used radiopharmaceutical with a half-life of 109.8 min. Having more than five years experience in this field we face lots of emergency conditions in the medical cyclotron facility. On the basis of harm we have divided in to three categories i.e. Harm of (a) working personnel, (b) Equipment and (c) environment. Radioactive gas leak and Target foil rupture is considered as the major emergency situations during medical cyclotron operations because there is a potential of over exposure to the working personnel. Radiation protection survey of a self-shielded medical cyclotron installation was carried out during normal and emergency conditions. It is found that the induced activity in the target foil increases with its successive usages. Recommendations have also been made to reduce personal exposure while handling the radioactive gas leak and target foil rupture conditions

  11. Uncertainty Prediction in Passive Target Motion Analysis

    Science.gov (United States)

    2016-05-12

    Number 15/152,696 Filing Date 12 May 2016 Inventor John G. Baylog et al Address any questions concerning this matter to the Office of...300118 1 of 25 UNCERTAINTY PREDICTION IN PASSIVE TARGET MOTION ANALYSIS STATEMENT OF GOVERNMENT INTEREST [0001] The invention described herein...at an unknown location and following an unknown course relative to an observer 12. Observer 12 has a sensor array such as a passive sonar or radar

  12. Is it wise to protect false targets?

    International Nuclear Information System (INIS)

    Levitin, Gregory; Hausken, Kjell

    2011-01-01

    The paper considers a system consisting of genuine elements and false targets that cannot be distinguished by the attacker's observation. The false targets can be destroyed with much less effort than the genuine elements. We show that even when an attacker cannot distinguish between the genuine elements and the false targets, in many cases it can enhance the attack efficiency using a double attack strategy in which it tries first to eliminate with minimal effort as many false targets as possible in the first attack and then distributes its entire remaining resource among all surviving targets in the second attack. The model for evaluating the system vulnerability in the double attack is suggested for a single genuine element, and multiple genuine elements configured in parallel or in series. This model assumes that in both attacks the attacking resource is distributed evenly among the attacked targets. The defender can optimize its limited resource distribution between deploying more false targets and protecting them better. The attacker can optimize its limited resource distribution between two attacks. The defense strategy is analyzed based on a two period minmax game. A numerical procedure is suggested that allows the defender to find the optimal resource distribution between deploying and protecting the false targets. The methodology of optimal attack and defense strategies analysis is demonstrated. It is shown that protecting the false targets may reduce the efficiency of the double attack strategy and make this strategy ineffective in situations with low contest intensity and few false targets. - Highlights: ► The efficiency of the double attack tactics against using false targets is analyzed. ► The role of the false target protection in system survivability enhancement is shown. ► The resource distribution between deploying more false targets and protecting them better is optimized. ► Both series and parallel systems are considered.

  13. Situational Method Engineering

    OpenAIRE

    Henderson-Sellers, Brian; Ralyte, Jolita; Par, Agerfalk; Rossi, Matti

    2014-01-01

    While previously available methodologies for software – like those published in the early days of object technology – claimed to be appropriate for every conceivable project, situational method engineering (SME) acknowledges that most projects typically have individual characteristics and situations. Thus, finding the most effective methodology for a particular project needs specific tailoring to that situation. Such a tailored software development methodology needs to take into account all t...

  14. SeedVicious: Analysis of microRNA target and near-target sites.

    Science.gov (United States)

    Marco, Antonio

    2018-01-01

    Here I describe seedVicious, a versatile microRNA target site prediction software that can be easily fitted into annotation pipelines and run over custom datasets. SeedVicious finds microRNA canonical sites plus other, less efficient, target sites. Among other novel features, seedVicious can compute evolutionary gains/losses of target sites using maximum parsimony, and also detect near-target sites, which have one nucleotide different from a canonical site. Near-target sites are important to study population variation in microRNA regulation. Some analyses suggest that near-target sites may also be functional sites, although there is no conclusive evidence for that, and they may actually be target alleles segregating in a population. SeedVicious does not aim to outperform but to complement existing microRNA prediction tools. For instance, the precision of TargetScan is almost doubled (from 11% to ~20%) when we filter predictions by the distance between target sites using this program. Interestingly, two adjacent canonical target sites are more likely to be present in bona fide target transcripts than pairs of target sites at slightly longer distances. The software is written in Perl and runs on 64-bit Unix computers (Linux and MacOS X). Users with no computing experience can also run the program in a dedicated web-server by uploading custom data, or browse pre-computed predictions. SeedVicious and its associated web-server and database (SeedBank) are distributed under the GPL/GNU license.

  15. Nuclear situation in Japan

    International Nuclear Information System (INIS)

    2006-01-01

    This analysis takes stock on the nuclear situation in Japan. It discusses the ambitious equipment program in collaboration with the France, the destabilization of the japanese nuclear industry following the accidents and the energy policy evolutions. It presents the projects of the japanese nuclear industry: the Monju reactor restart, the Pluthermal project, the reprocessing power plant of Rokkasho Mura, the new reactors, the russian weapons dismantling, the ITER site selection and the buy out of Westinghouse by Toshiba. (A.L.B.)

  16. Review of game theory applications for situation awareness

    Science.gov (United States)

    Blasch, Erik; Shen, Dan; Pham, Khanh D.; Chen, Genshe

    2015-05-01

    Game theoretical methods have been used for spectral awareness, space situational awareness (SSA), cyber situational awareness (CSA), and Intelligence, Surveillance, and Reconnaissance situation awareness (ISA). Each of these cases, awareness is supported by sensor estimation for assessment and the situation is determined from the actions of multiple players. Game theory assumes rational actors in a defined scenario; however, variations in social, cultural and behavioral factors include the dynamic nature of the context. In a dynamic data-driven application system (DDDAS), modeling must include both the measurements but also how models are used by different actors with different priorities. In this paper, we highlight the applications of game theory by reviewing the literature to determine the current state of the art and future needs. Future developments would include building towards knowledge awareness with information technology (e.g., data aggregation, access, indexing); multiscale analysis (e.g., space, time, and frequency), and software methods (e.g., architectures, cloud computing, protocols).

  17. Design of the solid target structure and the study on the coolant flow distribution in the solid target using the 2-dimensional flow analysis

    International Nuclear Information System (INIS)

    Haga, Katsuhiro; Terada, Atsuhiko; Ishikura, Shuichi; Teshigawara, Makoto; Kinoshita, Hidetaka; Kobayashi, Kaoru; Kaminaga, Masaki; Hino, Ryutaro; Susuki, Akira

    1999-11-01

    A solid target cooled by heavy water is presently under development under the Neutron Science Research Project of the Japan Atomic Energy Research Institute (JAERI). Target plates of several millimeters thickness made of heavy metal are used as the spallation target material and they are put face to face in a row with one to two millimeters gaps in between though which heavy water flows, as the coolant. Based on the design criteria regarding the target plate cooling, the volume percentage of the coolant, and the thermal stress produced in the target plates, we conducted thermal and hydraulic analysis with a one dimensional target plate model. We choosed tungsten as the target material, and decided on various target plate thicknesses. We then calculated the temperature and the thermal stress in the target plates using a two dimensional model, and confirmed the validity of the target plate thicknesses. Based on these analytical results, we proposed a target structure in which forty target plates are divided into six groups and each group is cooled using a single pass of coolant. In order to investigate the relationship between the distribution of the coolant flow, the pressure drop, and the coolant velocity, we conducted a hydraulic analysis using the general purpose hydraulic analysis code. As a result, we realized that an uniform coolant flow distribution can be achieved under a wide range of flow velocity conditions in the target plate cooling channels from 1 m/s to 10 m/s. The pressure drop along the coolant path was 0.09 MPa and 0.17 MPa when the coolant flow velocity was 5 m/s and 7 m/s respectively, which is required to cool the 1.5 MW and 2.5 MW solid targets. (author)

  18. Protein search for multiple targets on DNA

    Energy Technology Data Exchange (ETDEWEB)

    Lange, Martin [Johannes Gutenberg University, Mainz 55122 (Germany); Department of Chemistry, Rice University, Houston, Texas 77005 (United States); Kochugaeva, Maria [Department of Chemistry, Rice University, Houston, Texas 77005 (United States); Kolomeisky, Anatoly B., E-mail: tolya@rice.edu [Department of Chemistry, Rice University, Houston, Texas 77005 (United States); Center for Theoretical Biological Physics, Rice University, Houston, Texas 77005 (United States)

    2015-09-14

    Protein-DNA interactions are crucial for all biological processes. One of the most important fundamental aspects of these interactions is the process of protein searching and recognizing specific binding sites on DNA. A large number of experimental and theoretical investigations have been devoted to uncovering the molecular description of these phenomena, but many aspects of the mechanisms of protein search for the targets on DNA remain not well understood. One of the most intriguing problems is the role of multiple targets in protein search dynamics. Using a recently developed theoretical framework we analyze this question in detail. Our method is based on a discrete-state stochastic approach that takes into account most relevant physical-chemical processes and leads to fully analytical description of all dynamic properties. Specifically, systems with two and three targets have been explicitly investigated. It is found that multiple targets in most cases accelerate the search in comparison with a single target situation. However, the acceleration is not always proportional to the number of targets. Surprisingly, there are even situations when it takes longer to find one of the multiple targets in comparison with the single target. It depends on the spatial position of the targets, distances between them, average scanning lengths of protein molecules on DNA, and the total DNA lengths. Physical-chemical explanations of observed results are presented. Our predictions are compared with experimental observations as well as with results from a continuum theory for the protein search. Extensive Monte Carlo computer simulations fully support our theoretical calculations.

  19. Risk-targeted maps for Romania

    Science.gov (United States)

    Vacareanu, Radu; Pavel, Florin; Craciun, Ionut; Coliba, Veronica; Arion, Cristian; Aldea, Alexandru; Neagu, Cristian

    2018-03-01

    Romania has one of the highest seismic hazard levels in Europe. The seismic hazard is due to a combination of local crustal seismic sources, situated mainly in the western part of the country and the Vrancea intermediate-depth seismic source, which can be found at the bend of the Carpathian Mountains. Recent seismic hazard studies have shown that there are consistent differences between the slopes of the seismic hazard curves for sites situated in the fore-arc and back-arc of the Carpathian Mountains. Consequently, in this study we extend this finding to the evaluation of the probability of collapse of buildings and finally to the development of uniform risk-targeted maps. The main advantage of uniform risk approach is that the target probability of collapse will be uniform throughout the country. Finally, the results obtained are discussed in the light of a recent study with the same focus performed at European level using the hazard data from SHARE project. The analyses performed in this study have pointed out to a dominant influence of the quantile of peak ground acceleration used for anchoring the fragility function. This parameter basically alters the shape of the risk-targeted maps shifting the areas which have higher collapse probabilities from eastern Romania to western Romania, as its exceedance probability increases. Consequently, a uniform procedure for deriving risk-targeted maps appears as more than necessary.

  20. EFFECT OF BASIC SKILLS IN ANY SITUATION TESTS ACCURACY YOUNG PLAYERS

    Directory of Open Access Journals (Sweden)

    Artan R. Kryeziu

    2013-07-01

    Full Text Available The paper aims to establish the impact of basic motor skills in some situational accuracy tests in youth basketball game. In a sample of 60 tested age of 17 year + / - 6 months. We have applied eigjt variables to the tested persons, five of which are predicting, while the other three are criterion tests. Connectivity between motor variables is handled through the correlation of Pearson. The impact of variables predicting in those criteria used in regression analysis. Also significant importance is given to the introduction of connectivity between basic motor skills in several accuracy tests typical for the basketball game situations. Regarding the basic motor skills variables have attained significant coherence, however situational space test throwing the ball in the basket in the same direction and shooting the ball in the basket in the corner 450 degres no coherence with any test has been shown from the space of the appility of basic motor skills. Through regression analysis procedure we’ve reviewed the impact of basic motor skills in some situational accuracy tests. Treat analysis of criterion variables in those predicting we can say that accuracy to situational variables impact junior league players had explosive force. Therefore we can conclude that explosive strength is a quite important factor in the game between young basketball players, with there moving actions the playes can achive their goal of scoring points.

  1. Optimal strategies for controlling riverine tsetse flies using targets: a modelling study.

    Directory of Open Access Journals (Sweden)

    Glyn A Vale

    2015-03-01

    Full Text Available Tsetse flies occur in much of sub-Saharan Africa where they transmit the trypanosomes that cause the diseases of sleeping sickness in humans and nagana in livestock. One of the most economical and effective methods of tsetse control is the use of insecticide-treated screens, called targets, that simulate hosts. Targets have been ~1 m2, but recently it was shown that those tsetse that occupy riverine situations, and which are the main vectors of sleeping sickness, respond well to targets only ~0.06 m2. The cheapness of these tiny targets suggests the need to reconsider what intensity and duration of target deployments comprise the most cost-effective strategy in various riverine habitats.A deterministic model, written in Excel spreadsheets and managed by Visual Basic for Applications, simulated the births, deaths and movement of tsetse confined to a strip of riverine vegetation composed of segments of habitat in which the tsetse population was either self-sustaining, or not sustainable unless supplemented by immigrants. Results suggested that in many situations the use of tiny targets at high density for just a few months per year would be the most cost-effective strategy for rapidly reducing tsetse densities by the ~90% expected to have a great impact on the incidence of sleeping sickness. Local elimination of tsetse becomes feasible when targets are deployed in isolated situations, or where the only invasion occurs from populations that are not self-sustaining.Seasonal use of tiny targets deserves field trials. The ability to recognise habitat that contains tsetse populations which are not self-sustaining could improve the planning of all methods of tsetse control, against any species, in riverine, savannah or forest situations. Criteria to assist such recognition are suggested.

  2. Single-Molecule Analysis for RISC Assembly and Target Cleavage.

    Science.gov (United States)

    Sasaki, Hiroshi M; Tadakuma, Hisashi; Tomari, Yukihide

    2018-01-01

    RNA-induced silencing complex (RISC) is a small RNA-protein complex that mediates silencing of complementary target RNAs. Biochemistry has been successfully used to characterize the molecular mechanism of RISC assembly and function for nearly two decades. However, further dissection of intermediate states during the reactions has been warranted to fill in the gaps in our understanding of RNA silencing mechanisms. Single-molecule analysis with total internal reflection fluorescence (TIRF) microscopy is a powerful imaging-based approach to interrogate complex formation and dynamics at the individual molecule level with high sensitivity. Combining this technique with our recently established in vitro reconstitution system of fly Ago2-RISC, we have developed a single-molecule observation system for RISC assembly. In this chapter, we summarize the detailed protocol for single-molecule analysis of chaperone-assisted assembly of fly Ago2-RISC as well as its target cleavage reaction.

  3. Training Inference Making Skills Using a Situation Model Approach Improves Reading Comprehension

    Directory of Open Access Journals (Sweden)

    Lisanne eBos

    2016-02-01

    Full Text Available This study aimed to enhance third and fourth graders’ text comprehension at the situation model level. Therefore, we tested a reading strategy training developed to target inference making skills, which are widely considered to be pivotal to situation model construction. The training was grounded in contemporary literature on situation model-based inference making and addressed the source (text-based versus knowledge-based, type (necessary versus unnecessary for (re-establishing coherence, and depth of an inference (making single lexical inferences versus combining multiple lexical inferences, as well as the type of searching strategy (forward versus backward. Results indicated that, compared to a control group (n = 51, children who followed the experimental training (n = 67 improved their inference making skills supportive to situation model construction. Importantly, our training also resulted in increased levels of general reading comprehension and motivation. In sum, this study showed that a ‘level of text representation’-approach can provide a useful framework to teach inference making skills to third and fourth graders.

  4. Seismic analysis of fuel and target assemblies at a production reactor

    International Nuclear Information System (INIS)

    Braverman, J.I.; Wang, Y.K.

    1991-01-01

    This paper describes the unique modeling and analysis considerations used to assess the seismic adequacy of the fuel and target assemblies in a production reactor at Savannah River Site. This confirmatory analysis was necessary to provide assurance that the reactor can operate safely during a seismic event and be brought to a safe shutdown condition. The plant which was originally designed in the 1950's required to be assessed to more current seismic criteria. The design of the reactor internals and the magnitude of the structural responses enabled the use of a linear elastic dynamic analysis. A seismic analysis was performed using a finite element model consisting of the fuel and target assemblies, reactor tank, and a portion of the concrete structure supporting the reactor tank. The effects of submergence of the fuel and target assemblies in the water contained within the reactor tank can have a significant effect on their seismic response. Thus, the model included hydrodynamic fluid coupling effects between the assemblies and the reactor tank. Fluid coupling mass terms were based on formulations for solid bodies immersed in incompressible and frictionless fluids. The potential effects of gap conditions were also assessed in this evaluation. 5 refs., 6 figs., 1 tab

  5. Problems of sanitary-hygienic arrangements in case of emergency situations

    International Nuclear Information System (INIS)

    Avetisov, G.M.; Borisov, B.K.; Volkov, N.N.; Grachev, M.I.; Korostin, A.S.; Prostakishin, G.P.

    1995-01-01

    The planning and carrying out sanitary-hygienic arrangements in emergency situation are based on scientific-research, organizing-methodical and practical trends of activities including: the necessity of taking into consideration the risk of sanitary-hygienic complications as a result of emergency situation; elaboration of criteria and classification of hazards potential danger of industrial plants and territories; the establishment of system of providing sanitary-hygienic measures in emergency situation; working out prophylactic measures for prevention, localization and liquidation of sanitary-hygienic after-effects of emergency situation; development of the system of control and express-analysis of hazardous factors; elaboration of rating-methodical base and arrangements aimed at protection of health and life of people. 5 refs

  6. Virtual diplomacy: an analysis of the structure of the target audiences

    Directory of Open Access Journals (Sweden)

    V. V. Verbytska

    2016-03-01

    Full Text Available In the context of the global information society the communication processes, especially at the international level, become more important.  The effectiveness of communication depends primarily on its focus, i.e. on defining clearly the target audience which it should focus on. Virtual diplomacy, as a kind of political communication at the international level, is no exception.  The novelty, rapid development and dissemination of this phenomenon require profound analysis and elaboration of effective utilization strategies, including studying its recipients and target audiences. Purpose: identification, structuring and analysis of the recipients of virtual diplomacy as the audiences of international political communication. The study uses such research methods, as system analysis, structural functionalism, dialectics and synergy, comparison, critical analysis. Main results of the research: 1. The study examined the specifics of political communication in the context of the development of the global information society at the international level. 2. It also analyzed the recipients of virtual diplomacy as a kind of political communication at the international level. 3. The study highlighted the key target groups in the global Internet network based on the tasks performed by virtual diplomacy. 4. It proved the effectiveness of cooperation with each target group in the framework of virtual diplomacy. 5. It described the specifics of the work with each target group in the context of virtual diplomacy. Practical implications: The article may be useful for writing scientific theoretical studies, tests, essays and term papers, for designing special courses in universities in the sphere of international relations and international information. It can also be a guide for the authorities carrying out diplomatic activities and international information cooperation. Findings: In the context of the establishment of the global information society political

  7. Review Essay: Situational Analysis—Strauss Meets Foucault?

    Directory of Open Access Journals (Sweden)

    Rainer Diaz-Bone

    2012-11-01

    Full Text Available With the (German translation of the volume "Situational Analysis" by Adele CLARKE, a new approach to the development of Grounded Theory Methodology (GTM is presented. CLARKE radicalizes the methodological standpoint of classical pragmatism. She integrates structuralist and post-structuralist analytic elements into GTM. This review essay critically analyzes this new integration and employs the methodological notion of the "theory/methods package" introduced by CLARKE, which denotes the cohesion of theory, methodology and methods, and can be conceived as a kind of “methodic holism” (not to be confused with the different concept of methodological holism. CLARKE puts more emphasis on objects and power than classical GTM, and attempts to integrate a FOUCAULTian discourse model. However, she does not succeed in integrating the pragmatic and structuralist/post-structuralist methodologies in a fully coherent way. Her situational analysis does not incorporate a discourse-analytic methodology, and has not implemented the methods needed for a FOUCAULTian discourse analysis. Nevertheless, this valuable work presents an important development in pragmatic social research. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1301115

  8. Nutrition and food security policy in the Islamic Republic of Iran: situation analysis and roadmap towards 2021.

    Science.gov (United States)

    Damari, Behzad; Abdollahi, Zahra; Hajifaraji, Majid; Rezazadeh, Arezoo

    2018-05-03

    All government policies and programmes for food and nutrition security should include providing healthy food, as well as providing economic and social availability for all people. This study aimed to analyse the current situation of Iranian food and nutrition security and establish a road map towards 2021. The applied methods were situation analysis and a mixed qualitative-quantitative method. The conceptual method used for developing this national document encompassed three areas: sustainable food supply, food safety and nutrition. The outcomes of the Iranian food and nutrition security system in the past three decades include development of management infrastructure and improvement in food and nutrition security status. However, analysis of current programmes showed that there were some overlapping, intertwining and parallel works in the responsibilities of related organizations in the field of supervision of food safety (from production to supply). The national document produced as the outcome of this paper was communicated by the Iranian Ministry of Health in 2012 and has been running for 2 years. Selected ministries are responsible for implementation of 20 national programmes by the end of the 5th Economic, Social and Cultural Development Programme (2016-2011). The consensus of stakeholders by the end of the 6th Development Programme (2021) is to put all of the provinces in a safe or very safe situation in terms of food and nutrition security. The most important challenge in establishing national documents is to make them operational. This aim was achieved by an intersectoral nutrition and food security working group, which produced a general memorandum of understanding with the main organizations, the media, universities and private sector. Copyright © World Health Organization (WHO) 2018. Some rights reserved. This work is available under the CC BY-NC-SA 3.0 IGO license (https://creativecommons.org/licenses/by-nc-sa/3.0/igo).

  9. The cultural dimension of tightness-looseness: An analysis of situational constraint in Estonia and Greece.

    Science.gov (United States)

    Realo, Anu; Linnamägi, Karmen; Gelfand, Michele J

    2015-06-01

    The importance of tightness-looseness as a dimension that explains a considerable amount of variance between cultures was demonstrated by Gelfand et al. (2011). Tight nations have many strong norms and a low tolerance of deviant behaviour, whereas loose nations have weak social norms and a high tolerance of deviant behaviour. The main aim of the current studies was to examine situational constraint in Estonia and Greece: that is, how the cultural dimension of tightness-looseness is manifested in everyday situations in those two countries. The findings of a questionnaire study (Study 1) suggested that, in general, there is higher constraint across everyday situations in Greece than in Estonia, but situational constraint in Greece is especially strong in school and organisational settings where people have hierarchically structured roles. The results of an observational study (Study 2) revealed a relatively high agreement between appropriateness of certain behaviours as judged by the respondents in Study 1 and the frequencies of observed behaviours in the two countries. Our findings suggest that the strength of situations may substantially vary both within and across cultures, and that the attitudes of the members about situational strength in their respective cultures are in concordance with observations of situations by neutral observers in how people in general behave in their culture. © 2014 International Union of Psychological Science.

  10. Bioinformatic analysis of xenobiotic reactive metabolite target proteins and their interacting partners

    Directory of Open Access Journals (Sweden)

    Hanzlik Robert P

    2009-06-01

    Full Text Available Abstract Background Protein covalent binding by reactive metabolites of drugs, chemicals and natural products can lead to acute cytotoxicity. Recent rapid progress in reactive metabolite target protein identification has shown that adduction is surprisingly selective and inspired the hope that analysis of target proteins might reveal protein factors that differentiate target- vs. non-target proteins and illuminate mechanisms connecting covalent binding to cytotoxicity. Results Sorting 171 known reactive metabolite target proteins revealed a number of GO categories and KEGG pathways to be significantly enriched in targets, but in most cases the classes were too large, and the "percent coverage" too small, to allow meaningful conclusions about mechanisms of toxicity. However, a similar analysis of the directlyinteracting partners of 28 common targets of multiple reactive metabolites revealed highly significant enrichments in terms likely to be highly relevant to cytotoxicity (e.g., MAP kinase pathways, apoptosis, response to unfolded protein. Machine learning was used to rank the contribution of 211 computed protein features to determining protein susceptibility to adduction. Protein lysine (but not cysteine content and protein instability index (i.e., rate of turnover in vivo were among the features most important to determining susceptibility. Conclusion As yet there is no good explanation for why some low-abundance proteins become heavily adducted while some abundant proteins become only lightly adducted in vivo. Analyzing the directly interacting partners of target proteins appears to yield greater insight into mechanisms of toxicity than analyzing target proteins per se. The insights provided can readily be formulated as hypotheses to test in future experimental studies.

  11. The gas market and sector in France. Situation and predictions 2018 - Sector and competitive analysis

    International Nuclear Information System (INIS)

    2017-01-01

    Through a detailed analysis of market determining factors, of evolutions of supply and demand, and of major events in firms life, this set of two reports proposes an analysis of the recent situation of the gas sector and of the evolutions of the competitive game. The first report on situation and predictions which is updated three times a year, proposes a synthesis on the consequences of the evolution of the economic environment, on major trends noticed for the sector, and on predictable evolutions. It proposes the most recent predictions regarding natural gas consumption in France and the turnover of the gas sector. It highlights recent events for companies of the sector: takeovers, investments, restructuring, introduction of new products, and so on. It proposes a sector-based dashboard which contains all the critical figures useful to analyse the sector situation (activity determining factors, key figures for the sector and its environment). The second report (the annual one) proposes an overview of trends and competition within the gas sector. It gives an overview of some basic aspects of the activity (sector organisation, gas categories, main customer markets, gas consumption in industry), and of its determining factors, analyses the sector environment (sites connected to the natural gas network, evolution of average temperatures in France, production by chemical industry, by the food industry, and by metallurgy and oil refining, thermal production of electricity, regulatory evolution regarding supports to energy efficiency, and new opportunities). The evolution of the sector activity is analysed through its trends and indicators (turnovers, gas consumption, butane-propane deliveries, wholesale prices, regulated tariffs). The economic structure is also analysed: aspects related to the upstream part (extraction, injection of biogas, natural gas main input and output points, transport and storage, natural gas distribution), and aspects related to gas provision

  12. Targeting radiation to tumours

    International Nuclear Information System (INIS)

    Wheldon, T.E.; Greater Glasgow Health Board, Glasgow

    1994-01-01

    Biologically targeted radiotherapy entails the preferential delivery of radiation to solid tumours or individual tumour cells by means of tumour-seeking delivery vehicles to which radionuclides can be conjugated. Monoclonal antibodies have attracted attention for some years as potentially selective targeting agents, but advances in tumour and molecular biology are now providing a much wider choice of molecular species. General radiobiological principles may be derived which are applicable to most forms of targeted radiotherapy. These principles provide guidelines for the appropriate choice of radionuclide in specific treatment situations and its optimal combination with other treatment modalities. In future, the availability of gene targeting agents will focus attention on the use of Auger electron emitters whose high potency and short range selectivity makes them attractive choices for specific killing of cancer cells whose genetic peculiarities are known. (author)

  13. Target preparation and neutron activation analysis: a successful story at IRMM

    International Nuclear Information System (INIS)

    Robouch, P.; Arana, G.; Eguskiza, M.; Maguregui, M.I.; Pomme, S.; Ingelbrecht, C.

    2002-01-01

    The main task of a target producer is to make well characterized and homogeneous deposits on specific supports. Alpha and/or gamma spectrometry are traditionally used to monitor the quality of actinide deposits. With the increasing demand for enriched stable isotope targets, other analytical techniques, such as ICP-MS and NAA, are needed. This paper presents the application of neutron activation analysis to quality control of 'thin' targets, 'thicker' neutron dosimeters and 'thick' bronze disks prepared by the Reference Materials Unit at the Institute of Reference Materials and Measurements

  14. Target preparation and neutron activation analysis a successful story at IRMM

    CERN Document Server

    Robouch, P; Eguskiza, M; Maguregui, M I; Pommé, S; Ingelbrecht, C

    2002-01-01

    The main task of a target producer is to make well characterized and homogeneous deposits on specific supports. Alpha and/or gamma spectrometry are traditionally used to monitor the quality of actinide deposits. With the increasing demand for enriched stable isotope targets, other analytical techniques, such as ICP-MS and NAA, are needed. This paper presents the application of neutron activation analysis to quality control of 'thin' targets, 'thicker' neutron dosimeters and 'thick' bronze disks prepared by the Reference Materials Unit at the Institute of Reference Materials and Measurements.

  15. Situational method engineering

    CERN Document Server

    Henderson-Sellers, Brian; Ågerfalk, Pär J; Rossi, Matti

    2014-01-01

    While previously available methodologies for software ? like those published in the early days of object technology ? claimed to be appropriate for every conceivable project, situational method engineering (SME) acknowledges that most projects typically have individual characteristics and situations. Thus, finding the most effective methodology for a particular project needs specific tailoring to that situation. Such a tailored software development methodology needs to take into account all the bits and pieces needed for an organization to develop software, including the software process, the

  16. Interacting with target tracking algorithms in a gaze-enhanced motion video analysis system

    Science.gov (United States)

    Hild, Jutta; Krüger, Wolfgang; Heinze, Norbert; Peinsipp-Byma, Elisabeth; Beyerer, Jürgen

    2016-05-01

    Motion video analysis is a challenging task, particularly if real-time analysis is required. It is therefore an important issue how to provide suitable assistance for the human operator. Given that the use of customized video analysis systems is more and more established, one supporting measure is to provide system functions which perform subtasks of the analysis. Recent progress in the development of automated image exploitation algorithms allow, e.g., real-time moving target tracking. Another supporting measure is to provide a user interface which strives to reduce the perceptual, cognitive and motor load of the human operator for example by incorporating the operator's visual focus of attention. A gaze-enhanced user interface is able to help here. This work extends prior work on automated target recognition, segmentation, and tracking algorithms as well as about the benefits of a gaze-enhanced user interface for interaction with moving targets. We also propose a prototypical system design aiming to combine both the qualities of the human observer's perception and the automated algorithms in order to improve the overall performance of a real-time video analysis system. In this contribution, we address two novel issues analyzing gaze-based interaction with target tracking algorithms. The first issue extends the gaze-based triggering of a target tracking process, e.g., investigating how to best relaunch in the case of track loss. The second issue addresses the initialization of tracking algorithms without motion segmentation where the operator has to provide the system with the object's image region in order to start the tracking algorithm.

  17. An analysis of possible off target effects following CAS9/CRISPR targeted deletions of neuropeptide gene enhancers from the mouse genome.

    Science.gov (United States)

    Hay, Elizabeth Anne; Khalaf, Abdulla Razak; Marini, Pietro; Brown, Andrew; Heath, Karyn; Sheppard, Darrin; MacKenzie, Alasdair

    2017-08-01

    We have successfully used comparative genomics to identify putative regulatory elements within the human genome that contribute to the tissue specific expression of neuropeptides such as galanin and receptors such as CB1. However, a previous inability to rapidly delete these elements from the mouse genome has prevented optimal assessment of their function in-vivo. This has been solved using CAS9/CRISPR genome editing technology which uses a bacterial endonuclease called CAS9 that, in combination with specifically designed guide RNA (gRNA) molecules, cuts specific regions of the mouse genome. However, reports of "off target" effects, whereby the CAS9 endonuclease is able to cut sites other than those targeted, limits the appeal of this technology. We used cytoplasmic microinjection of gRNA and CAS9 mRNA into 1-cell mouse embryos to rapidly generate enhancer knockout mouse lines. The current study describes our analysis of the genomes of these enhancer knockout lines to detect possible off-target effects. Bioinformatic analysis was used to identify the most likely putative off-target sites and to design PCR primers that would amplify these sequences from genomic DNA of founder enhancer deletion mouse lines. Amplified DNA was then sequenced and blasted against the mouse genome sequence to detect off-target effects. Using this approach we were unable to detect any evidence of off-target effects in the genomes of three founder lines using any of the four gRNAs used in the analysis. This study suggests that the problem of off-target effects in transgenic mice have been exaggerated and that CAS9/CRISPR represents a highly effective and accurate method of deleting putative neuropeptide gene enhancer sequences from the mouse genome. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  18. Thermal analysis of LEU modified Cintichem target irradiated in TRIGA reactor

    International Nuclear Information System (INIS)

    Catana, A; Toma, C.

    2009-01-01

    Actions conceived during last years at international level for conversion of Molybdenum fabrication process from HEU to LEU targets utilization created opportunities for INR to get access to information and participating to international discussions under IAEA auspices. Concrete steps for developing fission Molybdenum technology were facilitated. Institute of Nuclear Research bringing together a number of conditions like suitable irradiation possibilities, direct communication between reactor and hot cell facility, handling capacity of high radioactive sources, and simultaneously the existence of an expanding internal market, decided to undertake the necessary steps in order to produce fission molybdenum. Over the course of last years of efforts in this direction we developed the steps for fission Molybdenum technology development based on modified Cintichem process in accordance with the Argonne National Laboratory proved methodology. Progress made by INR to heat transfer computations of annular target using is presented. An advanced thermal-hydraulic analysis was performed to estimate the heat removal capability for an enriched uranium (LEU) foil annular target irradiated in TRIGA reactor core. As a result, the present analysis provides an upper limit estimate of the LEU-foil and external target surface temperatures during irradiation in TRIGA 14 MW reactor. (authors)

  19. Analysis of Experimentation Results on University Graduates' Readiness Formation to Act in Extraordinary Situations

    Science.gov (United States)

    Moloshavenko, Vera L.; Prozorova, Galina V.; Sienkiewicz, Lyudmila B.

    2016-01-01

    The article presents the experimentation on graduates' readiness formation to act in extraordinary situations conducted in the Tyumen Industrial University in training bachelors in "Oil and Gas Business". The criteria of graduates' readiness formation to act in extraordinary situations are the following: practicability, validity,…

  20. Positioning accuracy analysis of adjusting target mechanism of three-dimensional attitude

    International Nuclear Information System (INIS)

    Ma Li; Wang Kun; Sun Linzhi; Zhou Shasha

    2012-01-01

    A novel adjusting target mechanism of three-dimensional attitude is presented according to the characteristics of the target transport subsystem in inertial confinement fusion (ICF). The mechanism consists of a tangent mechanism adjusting rotation angle and a set of orthogonal tangent mechanism adjusting two-dimensional deflection angles. The structural parameters of the adjusting target mechanism are analyzed according to principle errors, structure errors and motion errors of following. The analysis results indicate that the system error of the adjusting target mechanism is influenced by the displacement of the linear actuators, the actuator ball radius, the working radius of the tangent mechanism, the angle error of the inclined installation hole, the centralization error of the actuators, the orthogonal error of the two tangent mechanism, and the angle errors of the inclined target rod inclined rotation shaft. The errors of the inclined target rod and inclined rotation shaft are the two greatest impact factors, the spherical contact error is the next. By means of precise assembly and control system compensation, the accuracy of the adjusting target mechanism can be less than 0.1 mrad. (authors)

  1. Situation-assessment and decision-aid production-rule analysis system for nuclear plant monitoring and emergency preparedness

    International Nuclear Information System (INIS)

    Gvillo, D.; Ragheb, M.; Parker, M.; Swartz, S.

    1987-01-01

    A Production-Rule Analysis System is developed for Nuclear Plant Monitoring. The signals generated by the Zion-1 Plant are considered. A Situation-Assessment and Decision-Aid capability is provided for monitoring the integrity of the Plant Radiation, the Reactor Coolant, the Fuel Clad, and the Containment Systems. A total of 41 signals are currently fed as facts to an Inference Engine functioning in the backward-chaining mode and built along the same structure as the E-Mycin system. The Goal-Tree constituting the Knowledge Base was generated using a representation in the form of Fault Trees deduced from plant procedures information. The system is constructed in support of the Data Analysis and Emergency Preparedness tasks at the Illinois Radiological Emergency Assessment Center (REAC)

  2. Situation-Assessment And Decision-Aid Production-Rule Analysis System For Nuclear Plant Monitoring And Emergency Preparedness

    Science.gov (United States)

    Gvillo, D.; Ragheb, M.; Parker, M.; Swartz, S.

    1987-05-01

    A Production-Rule Analysis System is developed for Nuclear Plant Monitoring. The signals generated by the Zion-1 Plant are considered. A Situation-Assessment and Decision-Aid capability is provided for monitoring the integrity of the Plant Radiation, the Reactor Coolant, the Fuel Clad, and the Containment Systems. A total of 41 signals are currently fed as facts to an Inference Engine functioning in the backward-chaining mode and built along the same structure as the E-Mycin system. The Goal-Tree constituting the Knowledge Base was generated using a representation in the form of Fault Trees deduced from plant procedures information. The system is constructed in support of the Data Analysis and Emergency Preparedness tasks at the Illinois Radiological Emergency Assessment Center (REAC).

  3. Situational Leadership

    OpenAIRE

    Süttö, Marián

    2016-01-01

    This thesis is focused on field of leadership, particularly situational leadership model by Hersey and Blanchard. Thesis is mostly theoretical framework aimed to offer the possibility for reader to get overview in leadership issues. Theoretical framework of the thesis is focused on leadership definition, the most important leadership theories in the past, and especially to situational leadership approach. The focus of this thesis is to get detailed insight in this model and therefore offer in...

  4. Phishing for suitable targets in the Netherlands: routine activity theory and phishing victimization.

    Science.gov (United States)

    Leukfeldt, E Rutger

    2014-08-01

    This article investigates phishing victims, especially the increased or decreased risk of victimization, using data from a cybercrime victim survey in the Netherlands (n=10,316). Routine activity theory provides the theoretical perspective. According to routine activity theory, several factors influence the risk of victimization. A multivariate analysis was conducted to assess which factors actually lead to increased risk of victimization. The model included background and financial data of victims, their Internet activities, and the degree to which they were "digitally accessible" to an offender. The analysis showed that personal background and financial characteristics play no role in phishing victimization. Among eight Internet activities, only "targeted browsing" led to increased risk. As for accessibility, using popular operating systems and web browsers does not lead to greater risk, while having up-to-date antivirus software as a technically capable guardian has no effect. The analysis showed no one, clearly defined group has an increased chance of becoming a victim. Target hardening may help, but opportunities for prevention campaigns aimed at a specific target group or dangerous online activities are limited. Therefore, situational crime prevention will have to come from a different angle. Banks could play the role of capable guardian.

  5. Failure probability analysis on mercury target vessel

    International Nuclear Information System (INIS)

    Ishikura, Syuichi; Futakawa, Masatoshi; Kogawa, Hiroyuki; Sato, Hiroshi; Haga, Katsuhiro; Ikeda, Yujiro

    2005-03-01

    Failure probability analysis was carried out to estimate the lifetime of the mercury target which will be installed into the JSNS (Japan spallation neutron source) in J-PARC (Japan Proton Accelerator Research Complex). The lifetime was estimated as taking loading condition and materials degradation into account. Considered loads imposed on the target vessel were the static stresses due to thermal expansion and static pre-pressure on He-gas and mercury and the dynamic stresses due to the thermally shocked pressure waves generated repeatedly at 25 Hz. Materials used in target vessel will be degraded by the fatigue, neutron and proton irradiation, mercury immersion and pitting damages, etc. The imposed stresses were evaluated through static and dynamic structural analyses. The material-degradations were deduced based on published experimental data. As a result, it was quantitatively confirmed that the failure probability for the lifetime expected in the design is very much lower, 10 -11 in the safety hull, meaning that it will be hardly failed during the design lifetime. On the other hand, the beam window of mercury vessel suffered with high-pressure waves exhibits the failure probability of 12%. It was concluded, therefore, that the leaked mercury from the failed area at the beam window is adequately kept in the space between the safety hull and the mercury vessel by using mercury-leakage sensors. (author)

  6. Thermal Analysis of Fission Moly Target Solid Waste Storage

    Energy Technology Data Exchange (ETDEWEB)

    Son, Hyung Min; Park, Jonghark [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2016-10-15

    There are various ways to produce Mo-99. Among them, nuclear transmutation of uranium target became the major one owing to its superior specific activity. After the fission molybdenum (FM) target is irradiated, it is transported to treatment facility to extract wanted isotope. During the process, various forms of wastes are produced including filter cake and other solid wastes. The filter cake is mostly consisted of decaying uranium compounds. The solid wastes are then packaged and moved to storage facility which will stay there for considerable amount of time. Being the continuous source of heat, the solid wastes are required to be cooled for the certain amount of time before transported to the storage area. In this study, temperature evaluation of the storage facility is carried out with pre-cooling time sensitivity to check its thermal integrity. In this study, thermal analysis on the FM target solid waste storage is performed. Finite volume method is utilized to numerically discretize and solve the geometry of interest. Analysis shows that the developed method can simulate temperature behavior during storage process, but needs to be checked against other code to see calculation accuracy. Highest temperature distribution is observed when every hole is filled with waste containers. Sensitivity results on pre-cooling time shows that at least 13 months of cooling is necessary to keep the structure integrity.

  7. Kinetic analysis of the effects of target structure on siRNA efficiency

    Science.gov (United States)

    Chen, Jiawen; Zhang, Wenbing

    2012-12-01

    RNAi efficiency for target cleavage and protein expression is related to the target structure. Considering the RNA-induced silencing complex (RISC) as a multiple turnover enzyme, we investigated the effect of target mRNA structure on siRNA efficiency with kinetic analysis. The 4-step model was used to study the target cleavage kinetic process: hybridization nucleation at an accessible target site, RISC-mRNA hybrid elongation along with mRNA target structure melting, target cleavage, and enzyme reactivation. At this model, the terms accounting for the target accessibility, stability, and the seed and the nucleation site effects are all included. The results are in good agreement with that of experiments which show different arguments about the structure effects on siRNA efficiency. It shows that the siRNA efficiency is influenced by the integrated factors of target's accessibility, stability, and the seed effects. To study the off-target effects, a simple model of one siRNA binding to two mRNA targets was designed. By using this model, the possibility for diminishing the off-target effects by the concentration of siRNA was discussed.

  8. STANDARDIZATION OF UNCERTAINTY SITUATIONS IN TRAINING MODULES

    Directory of Open Access Journals (Sweden)

    Sergey A. Safontsev

    2015-01-01

    Full Text Available The aim of this study is the description of modular structure of the academic discipline in accordance with the requirements of Federal State Educational Standards.Methods. The authors use the methods of standardization of the educational system that are based on educational theory quality measurement. As the process of learning does not depend on the perspective of the diagnostician, the objectification of the results has been achieved by using relative units, allowing the authors to compare the effectiveness of different stages of education quality assessment with quantitative methods. Furthermore, sampling method, correlation and comparative analysis of statistical significance of the obtained distributions have been used to exclude from analytical data the results that were not confirmed experimentally.Results. Statistical methods are presented in a complex, allowing the authors to receive experimental result at level of the statistical importance of psychological and pedagogical researches. According to ideas of the competence-based education and general theory of systems and educational qualimetry, it is shown that constructs of vocational training are problem, test and detailed designs included in structure of educational modules. Funds of estimated means have been used to measure the level of trainee’s competences: – problematic situation of uncertainty orientation for current control; – situations of test and project orientation for boundary control at the end of each module, intermediate control in the form of the exam held at the end of the semester, as well as state certification of control at the end of the study at the university. Validity of the degree of interest of the learning process, reliability of coincidences constructive reflection of students’ own achievements with independent project performance and efficiency as the ratio of the result obtained to the costs of implementing the target function of the educational

  9. Interactive Purchasing Situations

    NARCIS (Netherlands)

    Groote Schaarsberg, M.; Borm, P.E.M.; Hamers, H.J.M.; Reijnierse, J.H.

    2012-01-01

    Abstract: This paper introduces a new class of interactive cooperative purchasing situations and provides an explicit alternative characterization of the nucleolus of cooperative games, which offers an alternative to Kohlberg (1971). In our cooperative purchasing situation, the unit price of a

  10. Sensitivity of the Game Control of Ship in Collision Situations

    Directory of Open Access Journals (Sweden)

    Lisowski Józef

    2015-12-01

    Full Text Available The paper introduces the application of the theory of deterministic sensitivity control systems for sensitivity analysis taking place in game control systems of moving objects, such as ships. The sensitivity of parametric model of game ship control process and game control in collision situations - sensitivity to changes in its parameters have been presented. First-order and k-th order sensitivity functions of parametric model of the process and game control are described. The structure of the game ship control system in collision situations and the mathematical model of game control process in the form of state equations are given. Characteristics of sensitivity functions of the model and game ship control process on the base of computer simulation in Matlab/Simulink software have been presented. At the end are given proposals regarding the use of sensitivity analysis to practical synthesis of computer-aided system navigator in potential collision situations.

  11. A BRDF-BPDF database for the analysis of Earth target reflectances

    Science.gov (United States)

    Breon, Francois-Marie; Maignan, Fabienne

    2017-01-01

    Land surface reflectance is not isotropic. It varies with the observation geometry that is defined by the sun, view zenith angles, and the relative azimuth. In addition, the reflectance is linearly polarized. The reflectance anisotropy is quantified by the bidirectional reflectance distribution function (BRDF), while its polarization properties are defined by the bidirectional polarization distribution function (BPDF). The POLDER radiometer that flew onboard the PARASOL microsatellite remains the only space instrument that measured numerous samples of the BRDF and BPDF of Earth targets. Here, we describe a database of representative BRDFs and BPDFs derived from the POLDER measurements. From the huge number of data acquired by the spaceborne instrument over a period of 7 years, we selected a set of targets with high-quality observations. The selection aimed for a large number of observations, free of significant cloud or aerosol contamination, acquired in diverse observation geometries with a focus on the backscatter direction that shows the specific hot spot signature. The targets are sorted according to the 16-class International Geosphere-Biosphere Programme (IGBP) land cover classification system, and the target selection aims at a spatial representativeness within the class. The database thus provides a set of high-quality BRDF and BPDF samples that can be used to assess the typical variability of natural surface reflectances or to evaluate models. It is available freely from the PANGAEA website (PANGAEA.864090" target="_blank">doi:10.1594/PANGAEA.864090). In addition to the database, we provide a visualization and analysis tool based on the Interactive Data Language (IDL). It allows an interactive analysis of the measurements and a comparison against various BRDF and BPDF analytical models. The present paper describes the input data, the selection principles, the database format, and the analysis tool

  12. Dynamics of Situation Definition

    Science.gov (United States)

    Park, Dongseop; Moro, Yuji

    2006-01-01

    Situation definition is the process and product of actors' interpretive activities toward a given situation. By reviewing a number of psychological studies conducted in experimental settings, we found that the studies have only explicated a part of the situation definition process and have neglected its dynamic aspects. We need to focus on the…

  13. Situation awareness and documentation of changes that affect patient outcomes in progress notes.

    Science.gov (United States)

    Tower, Marion; Chaboyer, Wendy

    2014-05-01

    To report on registered nurses' situation awareness as a precursor to decision-making when recording changes in patients' conditions. Progress notes are important to communicate patients' progress and detail changes in patients' conditions. However, documentation is often poorly completed. There is little work that examines nurses' decision-making during documentation. This study focused on describing situation awareness as a precursor to decision-making during documentation. This study used Endsley's (Situation Awareness Analysis and Measurement, 2000, Lawrence Erlbaum Associates, NJ) work on situation awareness to guide and conceptualise information. The study was situated in a naturalistic paradigm to provide an interpretation of nurses' decision-making. Think-aloud research methods and semi-structured interviews were employed to illuminate decision-making processes. Audio recordings and interview texts were individually examined for evidence of cues, informed by Endsley's (Situation Awareness Analysis and Measurement, 2000, Lawrence Erlbaum Associates, NJ) descriptions of situation awareness. As patients' conditions changed, nurses used complex mental models and pattern-matching of information, drawing on all 3 levels of situation awareness during documentation. Level 1 situation awareness provided context, level 2 situation awareness signified a change in condition and its significance for the patient, and level 3 situation awareness was evident when nurses thought aloud about what this information indicated. Three themes associated with changes in patients' conditions emerged: deterioration in condition, not responding to prescribed treatments as expected and issues related to professional practice that impacted on patients' conditions. Nurses used a complex mental model for decision-making, drawing on 3 levels of situation awareness. Hamm's cognitive continuum theory, when related to situation awareness, is a useful decision-making theory to provide a

  14. Perspective information in the cockpit as a target acquisition aid

    NARCIS (Netherlands)

    Breda, L. van; Veltman, H.A.

    1998-01-01

    In a simulator experiment, the potential benefits of perspective radar displays for situation awareness support were investigated. A target acquisition task was used in which fighter pilots were required to locate and intercept a target. The pilots were supported by a conventional plan-view radar

  15. [Effects of situational and individual variables on critical thinking expression].

    Science.gov (United States)

    Tanaka, Yuko; Kusumi, Takashi

    2016-04-01

    The present study examined when people decide to choose an expression that is based on critical thinking, and how situational and individual variables affect such a decision process. Given a conversation scenario including overgeneralization with two friends, participants decided whether to follow the conversation by a critical-thinking expression or not. The authors controlled purpose and topic as situational variables, and measured critical-thinking ability, critical-thinking disposition, and self-monitoring as individual variables. We conducted an experiment in which the situational variables were counterbalanced in a within-subject design with 60 university students. The results of logistic regression analysis showed differences within individuals in the decision process whether to choose a critical-thinking expression, and that some situational factors and some subscales of the individual measurements were related to the differences.

  16. Quantitation without Calibration: Response Profile as an Indicator of Target Amount.

    Science.gov (United States)

    Debnath, Mrittika; Farace, Jessica M; Johnson, Kristopher D; Nesterova, Irina V

    2018-06-21

    Quantitative assessment of biomarkers is essential in numerous contexts from decision-making in clinical situations to food quality monitoring to interpretation of life-science research findings. However, appropriate quantitation techniques are not as widely addressed as detection methods. One of the major challenges in biomarker's quantitation is the need to have a calibration for correlating a measured signal to a target amount. The step complicates the methodologies and makes them less sustainable. In this work we address the issue via a new strategy: relying on position of response profile rather than on an absolute signal value for assessment of a target's amount. In order to enable the capability we develop a target-probe binding mechanism based on a negative cooperativity effect. A proof-of-concept example demonstrates that the model is suitable for quantitative analysis of nucleic acids over a wide concentration range. The general principles of the platform will be applicable toward a variety of biomarkers such as nucleic acids, proteins, peptides, and others.

  17. Gamification for Measuring Cyber Security Situational Awareness

    Energy Technology Data Exchange (ETDEWEB)

    Fink, Glenn A.; Best, Daniel M.; Manz, David O.; Popovsky, V. M.; Endicott-Popovsky, Barbara E.

    2013-03-01

    Cyber defense competitions arising from U.S. service academy exercises, offer a platform for collecting data that can inform research that ranges from characterizing the ideal cyber warrior to describing behaviors during certain challenging cyber defense situations. This knowledge could lead to better preparation of cyber defenders in both military and civilian settings. This paper describes how one regional competition, the PRCCDC, a participant in the national CCDC program, conducted proof of concept experimentation to collect data during the annual competition for later analysis. The intent is to create an ongoing research agenda that expands on this current work and incorporates augmented cognition and gamification methods for measuring cybersecurity situational awareness under the stress of cyber attack.

  18. Designing to support situation awareness across distances

    DEFF Research Database (Denmark)

    Sonnenwald, Diane H.; Maglaughlin, Kelly L.; Whitton, Mary C.

    2004-01-01

    . The foundation for this framework is previous research in situation awareness and virtual reality, combined with our analysis of interviews with and observations of collaborating scientists. The framework suggests that situation awareness is comprised of contextual, task and process, and socio......-emotional information. Research in virtual reality systems suggests control, sensory, distraction and realism attributes of technology contribute to a sense of presence [Presence 7 (1998) 225]. We suggest that consideration of these attributes with respect to contextual, task and process, and socio......-emotional information provides insights to guide design decisions. We used the framework when designing a scientific collaboratory system. Results from a controlled experimental evaluation of the collaboratory system help illustrate the framework's utility....

  19. Entrepreneurship Education in Italian Universities: Trend, Situation and Opportunities

    Science.gov (United States)

    Iacobucci, Donato; Micozzi, Alessandra

    2012-01-01

    Purpose: The purpose of this paper is to provide an analysis of the present situation and recent evolution of entrepreneurship education in Italian universities and to discuss whether these courses and curricula match the demand for entrepreneurial competences. Design/methodology/approach: The empirical analysis is based on a census of…

  20. Situation analysis of physical independence of the equipment and safety circuits of Almaraz NPP regarding R.G. 1.75 rev.3 (2005)

    International Nuclear Information System (INIS)

    Seijas Portela, S.

    2010-01-01

    Situation analysis of physical independence of the electrical equipment and circuits CN safety Almaraz about R.G. 1.75 rev. 3. (2005) The aim of this paper is to present the work done in the analysis of the physical separation of redundant safety electrical equipment (emergency diesel generators, medium voltage, electrical cabinets, etc.) and physical separation of circuits and electrical conduits.

  1. Investigation and Analysis on Psychological Health Situation for Middle and Primary School Students in Xianning City

    Directory of Open Access Journals (Sweden)

    Hong Yanping

    2015-01-01

    Full Text Available This paper is used to know about the psychological health situation for middle and primary school students in Xianning City and provide a certain empirical basis for meaningful development of psychological health education and psychological assistance. This paper uses the MHT scale prepared by Bucheng Zhou professor et al. to conduct a test for 1000 students in 7 middle and primary schools in Xianning City. The detection rate of psychological health problem accounts for 1.6% where the positive detection rate of study anxiety ranks first (43.2%. The psychological health situations have much difference in sex (t = -4. 624, P<0. 001, and it’s lower in male students than female ones. There is a significant difference between the psychological health situation for only and non-only children (t = -2. 519, P<0. 01.There is a significant difference on the psychological health situation for primary school, middle school and high school students (F = 11. 3, P<0. 001, and the psychological health situation of primary school students is better than that for middle school students. It can be concluded that the psychological health situation of middle and primary school students in Xianning City is fairly good, and the psychological health situation for male student, only children and primary school student is also fairly good.

  2. Study of target and non-target interplay in spatial attention task.

    Science.gov (United States)

    Sweeti; Joshi, Deepak; Panigrahi, B K; Anand, Sneh; Santhosh, Jayasree

    2018-02-01

    Selective visual attention is the ability to selectively pay attention to the targets while inhibiting the distractors. This paper aims to study the targets and non-targets interplay in spatial attention task while subject attends to the target object present in one visual hemifield and ignores the distractor present in another visual hemifield. This paper performs the averaged evoked response potential (ERP) analysis and time-frequency analysis. ERP analysis agrees to the left hemisphere superiority over late potentials for the targets present in right visual hemifield. Time-frequency analysis performed suggests two parameters i.e. event-related spectral perturbation (ERSP) and inter-trial coherence (ITC). These parameters show the same properties for the target present in either of the visual hemifields but show the difference while comparing the activity corresponding to the targets and non-targets. In this way, this study helps to visualise the difference between targets present in the left and right visual hemifields and, also the targets and non-targets present in the left and right visual hemifields. These results could be utilised to monitor subjects' performance in brain-computer interface (BCI) and neurorehabilitation.

  3. Simulating Serial-Target Antibacterial Drug Synergies Using Flux Balance Analysis

    DEFF Research Database (Denmark)

    Krueger, Andrew S.; Munck, Christian; Dantas, Gautam

    2016-01-01

    Flux balance analysis (FBA) is an increasingly useful approach for modeling the behavior of metabolic systems. However, standard FBA modeling of genetic knockouts cannot predict drug combination synergies observed between serial metabolic targets, even though such synergies give rise to some of t...

  4. SPATIAL ANALYSIS TO SUPPORT GEOGRAPHIC TARGETING OF GENOTYPES TO ENVIRONMENTS

    Directory of Open Access Journals (Sweden)

    Glenn eHyman

    2013-03-01

    Full Text Available Crop improvement efforts have benefited greatly from advances in available data, computing technology and methods for targeting genotypes to environments. These advances support the analysis of genotype by environment interactions to understand how well a genotype adapts to environmental conditions. This paper reviews the use of spatial analysis to support crop improvement research aimed at matching genotypes to their most appropriate environmental niches. Better data sets are now available on soils, weather and climate, elevation, vegetation, crop distribution and local conditions where genotypes are tested in experimental trial sites. The improved data are now combined with spatial analysis methods to compare environmental conditions across sites, create agro-ecological region maps and assess environment change. Climate, elevation and vegetation data sets are now widely available, supporting analyses that were much more difficult even five or ten years ago. While detailed soil data for many parts of the world remains difficult to acquire for crop improvement studies, new advances in digital soil mapping are likely to improve our capacity. Site analysis and matching and regional targeting methods have advanced in parallel to data and technology improvements. All these developments have increased our capacity to link genotype to phenotype and point to a vast potential to improve crop adaptation efforts.

  5. Non-targeted analysis of unexpected food contaminants using LC-HRMS.

    Science.gov (United States)

    Kunzelmann, Marco; Winter, Martin; Åberg, Magnus; Hellenäs, Karl-Erik; Rosén, Johan

    2018-03-29

    A non-target analysis method for unexpected contaminants in food is described. Many current methods referred to as "non-target" are capable of detecting hundreds or even thousands of contaminants. However, they will typically still miss all other possible contaminants. Instead, a metabolomics approach might be used to obtain "true non-target" analysis. In the present work, such a method was optimized for improved detection capability at low concentrations. The method was evaluated using 19 chemically diverse model compounds spiked into milk samples to mimic unknown contamination. Other milk samples were used as reference samples. All samples were analyzed with UHPLC-TOF-MS (ultra-high-performance liquid chromatography time-of-flight mass spectrometry), using reversed-phase chromatography and electrospray ionization in positive mode. Data evaluation was performed by the software TracMass 2. No target lists of specific compounds were used to search for the contaminants. Instead, the software was used to sort out all features only occurring in the spiked sample data, i.e., the workflow resembled a metabolomics approach. Procedures for chemical identification of peaks were outside the scope of the study. Method, study design, and settings in the software were optimized to minimize manual evaluation and faulty or irrelevant hits and to maximize hit rate of the spiked compounds. A practical detection limit was established at 25 μg/kg. At this concentration, most compounds (17 out of 19) were detected as intact precursor ions, as fragments or as adducts. Only 2 irrelevant hits, probably natural compounds, were obtained. Limitations and possible practical use of the approach are discussed.

  6. The resources of adaptability in a situation of frustration: a comparative experimental study

    OpenAIRE

    Lyudmila M. Kolpakova

    2016-01-01

    The article deals with mechanisms for mobilizing the resources of the individual in a situation to overcome the frustration that is studied in the framework of the methodology of the subjective approach. The analysis used data from the experiment, organized as situation of frustration for students during the examination session. Used methods: φ* criterion (angular conversion Fischer), Q criterion Rosenbaum, goodness of fit Pearson (χ 2); methods comparison, analysis and synthe...

  7. Energy situation september 2002; Conjoncture energetique septembre 2002

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-10-01

    The monthly situation analysis in France is presented. Statistics are given for energy consumption, demand, import and export. A special attention is given to the primary energy, the solid fuels, the petroleum products, the natural gas and the electric power. (A.L.B.)

  8. Andrographolide: A potent antituberculosis compound that targets Aminoglycoside 2'-N-acetyltransferase in Mycobacterium tuberculosis.

    Science.gov (United States)

    Prabu, Amudha; Hassan, Sameer; Prabuseenivasan; Shainaba, A S; Hanna, L E; Kumar, Vanaja

    2015-09-01

    Tuberculosis (TB) still remains a major challenging infectious disease. The increased rate of emergence of multi-drug resistant and extensively-drug resistant strains of the organism has further complicated the situation, resulting in an urgent need for new anti-TB drugs. Antimycobacterial activity of Andrographis paniculata was evaluated using a rapid LRP assay and the probable targets were identified by docking analysis. The methanolic extract of A. paniculata showed maximum antimycobacterial activity at 250μg/ml against all the tested strains of M. tuberculosis (H37Rv, MDR, and drug sensitive). Based on bioassay guided fractionation, andrographolide was identified as the potent molecule. With the docking analysis, both ICDH (Isocitrate Dehydrogenase) and AAC (Aminoglycoside 2'-N-acetyltransferase) were predicted as targets of andrographolide in M. tuberculosis. Molecular simulation revealed that, ICDH showed low binding affinity to andrographolide. However, for AAC, the andrographolide was observed to be well within the active site after 10ns of molecular simulation. This suggests that ACC (PDB ID 1M4I) could be the probable target for andrographolide. Copyright © 2015 Elsevier Inc. All rights reserved.

  9. Knowledge-based driver assistance systems traffic situation description and situation feature relevance

    CERN Document Server

    Huelsen, Michael

    2014-01-01

    The comprehension of a traffic situation plays a major role in driving a vehicle. Interpretable information forms a basis for future projection, decision making and action performing, such as navigating, maneuvering and driving control. Michael Huelsen provides an ontology-based generic traffic situation description capable of supplying various advanced driver assistance systems with relevant information about the current traffic situation of a vehicle and its environment. These systems are enabled to perform reasonable actions and approach visionary goals such as injury and accident free driv

  10. Simulation of visual search in the natural 2-D situation

    OpenAIRE

    Blanka Borin

    2004-01-01

    The goal of this research was to imitate the process of visual search in a natural two-dimensional situation and also to investigate the influence of variable features on the speed of the visual search. The experiment was designed upon one of the most influential theories in the research field of the visual search phenomenon – The Feature Integration Theory (Treisman, 1982). Although the FIT theory claims, that in case of a larger number of synchronous targets the mechanism of attention...

  11. Women's Drinking Decisions in Heterosocial Situations: Development and Validation of Scenarios to Assess Influence of Attraction and Risk-Awareness.

    Science.gov (United States)

    Noel, Nora E; Ogle, Richard L; Maisto, Stephen A; Jackson, Lee A; Loomis, Randi B; Heaton, Jennifer A

    2016-07-01

    These three related studies created a set of ecologically valid scenarios for assessing relative associations of both attraction and sexual coercion risk-recognition in college women's heterosocial situational drinking decisions. The first study constructed nine scenarios using input from heterosexual drinking women in the age cohort (18-30) most likely to experience alcohol-related sexual coercion. In the second study, 50 female undergraduates (ages 18-25) assessed the salience of three important dimensions (attraction, risk, and realism) in these scenarios. The third study was a factor analysis (and a follow-up confirmatory factor analysis) of the elements of coercion-risk as perceived by the target group with two female samples recruited 1 year apart (Sample 1: N = 157, ages 18-29); Sample 2: N = 157, ages 18-30). Results confirmed that the scenarios could be a useful vehicle for assessing how women balance out risk and attraction to make in-the moment heterosocial drinking decisions. The factor analysis showed participants perceived two types of situations, based on whether the male character was "Familiar" or "Just Met" and perceived themselves as happier and more excited with Familiar males. However, in contrast to HIV risk studies, Familiar males were perceived as higher risk for unwanted sex. Future research will use the six scenarios that emerged from the factor analysis to study how attraction and risk perception differentially affect young adult women's social drinking decisions.

  12. Genetically Modified Products in Lithuania: Situational Analysis and Consumers’ Attitudes

    OpenAIRE

    Dainora Grundey; Indre Rimkiene

    2012-01-01

    The paper analyses the genetically modified organism products (GMP) in relation to genetically modified organisms (GMO) from two perspectives: 1) from the theoretical standpoint, discussing the GMO and GMP trade conditions and 2) from the practical perspective, namely analysing the availability of GMP in the Lithuanian market. With the growing of genetically modified products (GMP) levels, it becomes important to examine the situation of genetically modified products. According to various stu...

  13. Introduction to charm decay analysis in fixed target experiments

    Energy Technology Data Exchange (ETDEWEB)

    Bediaga, Ignacio; Goebel, Carla

    1996-01-01

    We present an introduction to data analysis in Experimental High Energy Physics, and some concepts and useful tools are discussed. To illustrate, we use the data of E-791, a fixed target experiment recently realized at Fermilab. In particular, we analyse decay modes of D{sup +} meson with three charged particles in the final state. (author). 8 refs., 22 figs., 1 tab.

  14. Introduction to charm decay analysis in fixed target experiments

    International Nuclear Information System (INIS)

    Bediaga, Ignacio; Goebel, Carla.

    1996-01-01

    We present an introduction to data analysis in Experimental High Energy Physics, and some concepts and useful tools are discussed. To illustrate, we use the data of E-791, a fixed target experiment recently realized at Fermilab. In particular, we analyse decay modes of D + meson with three charged particles in the final state. (author). 8 refs., 22 figs., 1 tab

  15. TargetVue: Visual Analysis of Anomalous User Behaviors in Online Communication Systems.

    Science.gov (United States)

    Cao, Nan; Shi, Conglei; Lin, Sabrina; Lu, Jie; Lin, Yu-Ru; Lin, Ching-Yung

    2016-01-01

    Users with anomalous behaviors in online communication systems (e.g. email and social medial platforms) are potential threats to society. Automated anomaly detection based on advanced machine learning techniques has been developed to combat this issue; challenges remain, though, due to the difficulty of obtaining proper ground truth for model training and evaluation. Therefore, substantial human judgment on the automated analysis results is often required to better adjust the performance of anomaly detection. Unfortunately, techniques that allow users to understand the analysis results more efficiently, to make a confident judgment about anomalies, and to explore data in their context, are still lacking. In this paper, we propose a novel visual analysis system, TargetVue, which detects anomalous users via an unsupervised learning model and visualizes the behaviors of suspicious users in behavior-rich context through novel visualization designs and multiple coordinated contextual views. Particularly, TargetVue incorporates three new ego-centric glyphs to visually summarize a user's behaviors which effectively present the user's communication activities, features, and social interactions. An efficient layout method is proposed to place these glyphs on a triangle grid, which captures similarities among users and facilitates comparisons of behaviors of different users. We demonstrate the power of TargetVue through its application in a social bot detection challenge using Twitter data, a case study based on email records, and an interview with expert users. Our evaluation shows that TargetVue is beneficial to the detection of users with anomalous communication behaviors.

  16. Proficiency test in the analysis of gamma spectra for malevolent radiological situations (MALRAD)

    International Nuclear Information System (INIS)

    Dowdall, M.; Andersson, K.; Singh Sidhu, R.; Palsson, S.E.

    2009-11-01

    The MALRAD activity was intended to provide an exercise activity with respect to gamma ray spectrometric response to malevolent situations involving radioactive sources. Such situations can often be characterised by high activity sources in difficult contexts where the response is by necessity conducted with less than optimal instrumentation. Seven scenarios were developed based on previous incidents where possible and gamma spectral data and other information was disseminated to participants who were given one week to respond to each scenario with as much information as possible. In total 14 individual laboratories responded. The majority of laboratories were in a position to satisfactorily identify sources where single sources were used in situations with no complicating factors. For those scenarios involving heavy shielding some difficulties were encountered due to distortion of the spectrum from that which would normally be viewed as characteristic for the isotope in question. Special nuclear materials such as reprocessed enriched uranium and weapons grade plutonium provided different challenges and there were indications in the responses from participants of unfamiliarity with these materials. (author)

  17. Proficiency test in the analysis of gamma spectra for malevolent radiological situations (MALRAD)

    Energy Technology Data Exchange (ETDEWEB)

    Dowdall, M. (Norwegian Radiation Protection Autority, OEsteraas (Norway)); Andersson, K. (Technical Univ. of Denmark, Risoe National Lab. for Sustainable Energy, Roskilde (Denmark)); Singh Sidhu, R. (Institute for Energy Technology, Kjeller (Norway)); Paulsson, S.E. (Icelandic Radiation Protection Institute (IS))

    2009-11-15

    The MALRAD activity was intended to provide an exercise activity with respect to gamma ray spectrometric response to malevolent situations involving radioactive sources. Such situations can often be characterised by high activity sources in difficult contexts where the response is by necessity conducted with less than optimal instrumentation. Seven scenarios were developed based on previous incidents where possible and gamma spectral data and other information was disseminated to participants who were given one week to respond to each scenario with as much information as possible. In total 14 individual laboratories responded. The majority of laboratories were in a position to satisfactorily identify sources where single sources were used in situations with no complicating factors. For those scenarios involving heavy shielding some difficulties were encountered due to distortion of the spectrum from that which would normally be viewed as characteristic for the isotope in question. Special nuclear materials such as reprocessed enriched uranium and weapons grade plutonium provided different challenges and there were indications in the responses from participants of unfamiliarity with these materials. (author)

  18. Global analysis of small molecule binding to related protein targets.

    Directory of Open Access Journals (Sweden)

    Felix A Kruger

    2012-01-01

    Full Text Available We report on the integration of pharmacological data and homology information for a large scale analysis of small molecule binding to related targets. Differences in small molecule binding have been assessed for curated pairs of human to rat orthologs and also for recently diverged human paralogs. Our analysis shows that in general, small molecule binding is conserved for pairs of human to rat orthologs. Using statistical tests, we identified a small number of cases where small molecule binding is different between human and rat, some of which had previously been reported in the literature. Knowledge of species specific pharmacology can be advantageous for drug discovery, where rats are frequently used as a model system. For human paralogs, we demonstrate a global correlation between sequence identity and the binding of small molecules with equivalent affinity. Our findings provide an initial general model relating small molecule binding and sequence divergence, containing the foundations for a general model to anticipate and predict within-target-family selectivity.

  19. A study on the operator's communication pattern characteristics under abnormal operating situation of nuclear power plants

    International Nuclear Information System (INIS)

    Kim, S. H.; Park, J.

    2008-01-01

    The quality of a probabilistic safety assessment (PSA) has become more important and a human reliability analysis (HRA) is known as a major contributor to the uncertainty of a PSA. As a part of enhancing the HRA quality, a study was initiated to find out characteristics of communication pattern and to evaluate communication quality of the operators of nuclear power plants. Korea Atomic Energy Research Institute (KAERI) is developing evaluation methods for the effect of human-induced events on risk/performance. This paper describes a study on the operator's communication pattern characteristics under abnormal operating situation of nuclear power plants. The study was carried out in four stages; 1) Video recording 2) Audio scripting 3) Message Classification 4) Communication Pattern Analysis. We recorded eight abnormal simulator training programs from Younggwang nuclear power plant training center. After that we performed message classification and carried out communication pattern analysis. We compared communication patterns of abnormal operating situation with emergency operating situation.As results of analysis, the role of SRO (senior reactor operator) under abnormal operating situation was decreased than the activities under emergency operating situation because each operator (reactor operator, turbine operator, safety supervisor) in main control room (MCR) performs the activity to control by himself with corresponding field engineers with his basic knowledge of the system. On the other hand, the operator's decision making processes and activities under abnormal operating situation were dramatically increased than the emergency operating situation. (authors)

  20. Identification and analysis of unsatisfactory psychosocial work situations: a participatory approach employing video-computer interaction.

    Science.gov (United States)

    Hanse, J J; Forsman, M

    2001-02-01

    A method for psychosocial evaluation of potentially stressful or unsatisfactory situations in manual work was developed. It focuses on subjective responses regarding specific situations and is based on interactive worker assessment when viewing video recordings of oneself. The worker is first video-recorded during work. The video is then displayed on the computer terminal, and the filmed worker clicks on virtual controls on the screen whenever an unsatisfactory psychosocial situation appears; a window of questions regarding psychological demands, mental strain and job control is then opened. A library with pictorial information and comments on the selected situations is formed in the computer. The evaluation system, called PSIDAR, was applied in two case studies, one of manual materials handling in an automotive workshop and one of a group of workers producing and testing instrument panels. The findings indicate that PSIDAR can provide data that are useful in a participatory ergonomic process of change.

  1. Human microRNA target analysis and gene ontology clustering by GOmir, a novel stand-alone application.

    Science.gov (United States)

    Roubelakis, Maria G; Zotos, Pantelis; Papachristoudis, Georgios; Michalopoulos, Ioannis; Pappa, Kalliopi I; Anagnou, Nicholas P; Kossida, Sophia

    2009-06-16

    microRNAs (miRNAs) are single-stranded RNA molecules of about 20-23 nucleotides length found in a wide variety of organisms. miRNAs regulate gene expression, by interacting with target mRNAs at specific sites in order to induce cleavage of the message or inhibit translation. Predicting or verifying mRNA targets of specific miRNAs is a difficult process of great importance. GOmir is a novel stand-alone application consisting of two separate tools: JTarget and TAGGO. JTarget integrates miRNA target prediction and functional analysis by combining the predicted target genes from TargetScan, miRanda, RNAhybrid and PicTar computational tools as well as the experimentally supported targets from TarBase and also providing a full gene description and functional analysis for each target gene. On the other hand, TAGGO application is designed to automatically group gene ontology annotations, taking advantage of the Gene Ontology (GO), in order to extract the main attributes of sets of proteins. GOmir represents a new tool incorporating two separate Java applications integrated into one stand-alone Java application. GOmir (by using up to five different databases) introduces miRNA predicted targets accompanied by (a) full gene description, (b) functional analysis and (c) detailed gene ontology clustering. Additionally, a reverse search initiated by a potential target can also be conducted. GOmir can freely be downloaded BRFAA.

  2. Gender differences in trusting strangers: Role of the target's gender.

    Science.gov (United States)

    Zhao, Na; Zhang, Jianxin

    2016-06-01

    Previous findings on gender differences in the behaviors of individuals, including trusting behaviors, are inconsistent. A criticism is that these studies neglect contextual factors. The present study aims to examine how the target's gender, as a primary context factor, influences the trusting behavior of individuals in one survey and two experimental situations. Results indicate that people tend to trust strangers of the opposite gender more than those of the same gender in mixed-gender situations. Furthermore, females trust females much more than males trust males. The results help people understand that when talking about gender differences in interpersonal situations, the gender identity of target persons should be considered. These findings are somewhat in conflict with those of previous studies conducted in Western cultures, and suggest that culture should also be explored in future studies on gender differences in interpersonal relationships. © 2016 The Institute of Psychology, Chinese Academy of Sciences and John Wiley & Sons Australia, Ltd.

  3. WEBEXPIR: Windowless target electron beam experimental irradiation

    International Nuclear Information System (INIS)

    Dierckx, Marc; Schuurmans, Paul; Heyse, Jan; Rosseel, Kris; Tichelen, Katrien Van; Nactergal, Benoit; Vandeplassche, Dirk; Aoust, Thierry; Abs, Michel; Guertin, Arnaud; Buhour, Jean-Michel; Cadiou, Arnaud; Abderrahim, Hamid Ait

    2008-01-01

    The windowless target electron beam experimental irradiation (WEBEXPIR) program was set-up as part of the MYRRHA/XT-ADS R and D effort on the spallation target design to investigate the interaction of a proton beam with a liquid lead-bismuth eutectic (LBE) free surface. In particular, possible free surface distortion or shockwave effects in nominal conditions and during sudden beam on/off transient situations, as well as possible enhanced evaporation were assessed. An experiment was conceived at the IBA TT-1000 Rhodotron, where a 7 MeV electron beam was used to simulate the high power deposition at the MYRRHA/XT-ADS LBE free surface. The geometry and the LBE flow characteristics in the WEBEXPIR set-up were made as representative as possible of the actual situation in the MYRRHA/XT-ADS spallation target. Irradiation experiments were carried out at beam currents of up to 10 mA, corresponding to 40 times the nominal beam current necessary to reproduce the MYRRHA/XT-ADS conditions. Preliminary analyses show that the WEBEXPIR free surface flow was not disturbed by the interaction with the electron beam and that vacuum conditions stayed well within the design specifications

  4. Energy situation August 2005; Conjoncture energetique aout 2005

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-09-15

    The monthly energy situation analysis in France at August 2005 is presented. Statistics are given for energy consumption, demand, import and export. A special attention is given to the primary energy, the solid fuels, the petroleum products, the natural gas and the electric power. (A.L.B.)

  5. Energy situation september 2005; Conjoncture energetique septembre 2005

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-10-15

    The monthly energy situation analysis in France at september 2005, is presented. Statistics are given for energy consumption, demand, import and export. A special attention is given to the primary energy, the solid fuels, the petroleum products, the natural gas and the electric power. (A.L.B.)

  6. Energy situation, January 2006; Conjoncture energetique, janvier 2006

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-03-15

    The monthly energy situation analysis in France, at January 2006, is presented. Statistics are given for energy consumption, demand, import and export. A special attention is given to the primary energy, the solid fuels, the petroleum products, the natural gas and the electric power. (A.L.B.)

  7. In-depth resistome analysis by targeted metagenomics.

    Science.gov (United States)

    Lanza, Val F; Baquero, Fernando; Martínez, José Luís; Ramos-Ruíz, Ricardo; González-Zorn, Bruno; Andremont, Antoine; Sánchez-Valenzuela, Antonio; Ehrlich, Stanislav Dusko; Kennedy, Sean; Ruppé, Etienne; van Schaik, Willem; Willems, Rob J; de la Cruz, Fernando; Coque, Teresa M

    2018-01-15

    Antimicrobial resistance is a major global health challenge. Metagenomics allows analyzing the presence and dynamics of "resistomes" (the ensemble of genes encoding antimicrobial resistance in a given microbiome) in disparate microbial ecosystems. However, the low sensitivity and specificity of available metagenomic methods preclude the detection of minority populations (often present below their detection threshold) and/or the identification of allelic variants that differ in the resulting phenotype. Here, we describe a novel strategy that combines targeted metagenomics using last generation in-solution capture platforms, with novel bioinformatics tools to establish a standardized framework that allows both quantitative and qualitative analyses of resistomes. We developed ResCap, a targeted sequence capture platform based on SeqCapEZ (NimbleGene) technology, which includes probes for 8667 canonical resistance genes (7963 antibiotic resistance genes and 704 genes conferring resistance to metals or biocides), and 2517 relaxase genes (plasmid markers) and 78,600 genes homologous to the previous identified targets (47,806 for antibiotics and 30,794 for biocides or metals). Its performance was compared with metagenomic shotgun sequencing (MSS) for 17 fecal samples (9 humans, 8 swine). ResCap significantly improves MSS to detect "gene abundance" (from 2.0 to 83.2%) and "gene diversity" (26 versus 14.9 genes unequivocally detected per sample per million of reads; the number of reads unequivocally mapped increasing up to 300-fold by using ResCap), which were calculated using novel bioinformatic tools. ResCap also facilitated the analysis of novel genes potentially involved in the resistance to antibiotics, metals, biocides, or any combination thereof. ResCap, the first targeted sequence capture, specifically developed to analyze resistomes, greatly enhances the sensitivity and specificity of available metagenomic methods and offers the possibility to analyze genes

  8. STATISTIC AND ECONOMETRIC ANALYSIS OF THE MOTIVATIONL FACTORS ON TURISTC BEHAVOUR

    OpenAIRE

    Dumitru Nicoleta-Rossela; Zaharia Marian; Gogonea Rodica-Manuela

    2009-01-01

    The paper present the main customer reasons for the choice to practice rural tourism activities. The survey targeted focused on analysis and opinion on the situation of people at a time of rural tourism activity overall, assessed primarily through the pr

  9. Situational simulations in interactive video

    Energy Technology Data Exchange (ETDEWEB)

    Smith, L.J.

    1991-07-01

    The Westinghouse Hanford Company Advanced Training Technologies section is using situational simulations in several Interactive Video training courses. Two applications of situational simulations will be discussed. In the first, used in the Hanford General Employee Training course, the student evaluates employee's actions in simulations of possible workplace situations. In the second, used in the Criticality Safety course, students must follow well-defined procedures to complete tasks. Design and incorporation of situational simulations will be discussed. 3 refs.

  10. Situational simulations in interactive video

    International Nuclear Information System (INIS)

    Smith, L.J.

    1991-07-01

    The Westinghouse Hanford Company Advanced Training Technologies section is using situational simulations in several Interactive Video training courses. Two applications of situational simulations will be discussed. In the first, used in the Hanford General Employee Training course, the student evaluates employee's actions in simulations of possible workplace situations. In the second, used in the Criticality Safety course, students must follow well-defined procedures to complete tasks. Design and incorporation of situational simulations will be discussed. 3 refs

  11. What the drivers do and do not tell you: using verbal protocol analysis to investigate driver behaviour in emergency situations.

    Science.gov (United States)

    Banks, Victoria A; Stanton, Neville A; Harvey, Catherine

    2014-01-01

    Although task analysis of pedestrian detection can provide us with useful insights into how a driver may behave in emergency situations, the cognitive elements of driver decision-making are less well understood. To assist in the design of future Advanced Driver Assistance Systems, such as Autonomous Emergency Brake systems, it is essential that the cognitive elements of the driving task are better understood. This paper uses verbal protocol analysis in an exploratory fashion to uncover the thought processes underlying behavioural outcomes represented by hard data collected using the Southampton University Driving Simulator.

  12. Eye tracking a self-moved target with complex hand-target dynamics

    Science.gov (United States)

    Landelle, Caroline; Montagnini, Anna; Madelain, Laurent

    2016-01-01

    Previous work has shown that the ability to track with the eye a moving target is substantially improved when the target is self-moved by the subject's hand compared with when being externally moved. Here, we explored a situation in which the mapping between hand movement and target motion was perturbed by simulating an elastic relationship between the hand and target. Our objective was to determine whether the predictive mechanisms driving eye-hand coordination could be updated to accommodate this complex hand-target dynamics. To fully appreciate the behavioral effects of this perturbation, we compared eye tracking performance when self-moving a target with a rigid mapping (simple) and a spring mapping as well as when the subject tracked target trajectories that he/she had previously generated when using the rigid or spring mapping. Concerning the rigid mapping, our results confirmed that smooth pursuit was more accurate when the target was self-moved than externally moved. In contrast, with the spring mapping, eye tracking had initially similar low spatial accuracy (though shorter temporal lag) in the self versus externally moved conditions. However, within ∼5 min of practice, smooth pursuit improved in the self-moved spring condition, up to a level similar to the self-moved rigid condition. Subsequently, when the mapping unexpectedly switched from spring to rigid, the eye initially followed the expected target trajectory and not the real one, thereby suggesting that subjects used an internal representation of the new hand-target dynamics. Overall, these results emphasize the stunning adaptability of smooth pursuit when self-maneuvering objects with complex dynamics. PMID:27466129

  13. CFD Analysis of the Active Part of the HYPER Spallation Target

    International Nuclear Information System (INIS)

    Nam-il Tak; Chungho Cho; Tae-Yung Song

    2006-01-01

    KAERI (Korea Atomic Energy Research Institute) is developing an accelerator driven system (ADS) named HYPER (HYbrid Power Extraction Reactor) for a transmutation of long-lived nuclear wastes. One of the challenging tasks for the HYPER system is to design a large spallation target having a beam power of 15∼25 MW. The present paper focuses on the thermal-hydraulic performance of the active part of the HYPER target. Computational fluid dynamics (CFD) analysis was performed using a commercial code CFX 5.7.1. Several advanced turbulence models with different grid structures were applied. The CFX results show the significant impact of the turbulence model on the window temperature. It is concluded that experimental verifications are very important for the design of the HYPER target. (authors)

  14. Research progess on treatment of cancer with targeted radionuclide therapy

    International Nuclear Information System (INIS)

    Luo Jiawen; Zhang Caixia

    2008-01-01

    The new development and situation of targeted radionuclide therapy in oncology is described, which include radioimmunotherapy, peptide receptor radionuclide therapy, gene therapy and radionuclide labled chemotherapeutics therapy. The application research on labled carrier of those therapy is emphasized. Meanwhile, the research progess of indomethacin and its combined with targeted radionuclide therapy is also described. (authors)

  15. Genome-Wide Analysis of miRNA targets in Brachypodium and Biomass Energy Crops

    Energy Technology Data Exchange (ETDEWEB)

    Green, Pamela J. [Univ. of Delaware, Newark, DE (United States)

    2015-08-11

    MicroRNAs (miRNAs) contribute to the control of numerous biological processes through the regulation of specific target mRNAs. Although the identities of these targets are essential to elucidate miRNA function, the targets are much more difficult to identify than the small RNAs themselves. Before this work, we pioneered the genome-wide identification of the targets of Arabidopsis miRNAs using an approach called PARE (German et al., Nature Biotech. 2008; Nature Protocols, 2009). Under this project, we applied PARE to Brachypodium distachyon (Brachypodium), a model plant in the Poaceae family, which includes the major food grain and bioenergy crops. Through in-depth global analysis and examination of specific examples, this research greatly expanded our knowledge of miRNAs and target RNAs of Brachypodium. New regulation in response to environmental stress or tissue type was found, and many new miRNAs were discovered. More than 260 targets of new and known miRNAs with PARE sequences at the precise sites of miRNA-guided cleavage were identified and characterized. Combining PARE data with the small RNA data also identified the miRNAs responsible for initiating approximately 500 phased loci, including one of the novel miRNAs. PARE analysis also revealed that differentially expressed miRNAs in the same family guide specific target RNA cleavage in a correspondingly tissue-preferential manner. The project included generation of small RNA and PARE resources for bioenergy crops, to facilitate ongoing discovery of conserved miRNA-target RNA regulation. By associating specific miRNA-target RNA pairs with known physiological functions, the research provides insights about gene regulation in different tissues and in response to environmental stress. This, and release of new PARE and small RNA data sets should contribute basic knowledge to enhance breeding and may suggest new strategies for improvement of biomass energy crops.

  16. Situation awareness and workload in complex tactical environments

    NARCIS (Netherlands)

    Veltman, J.A.

    1999-01-01

    The paper provides an example of a method to get insight into workload changes over time, executed tasks and situation awareness (SA) in complex task environments. The method is applied to measure the workload of a helicopter crew. The method has three components: 1) task analysis, 2) video

  17. The French nuclear sector. Situation and predictions 2018 - Sectoral and competitive analysis

    International Nuclear Information System (INIS)

    2017-01-01

    This document comprises two reports. A first one, published and updated three times a year, and a second one which is a yearly publication. The first one, based on an analysis of market perspectives and of actor strategies, proposes a synthesis on the consequences of the evolution of the economic environment, on major trends noticed for the nuclear sector, and on predictable evolutions. It proposes the most recent data regarding the activities of more than 100 firms belonging to the sector (notably in terms of electric power production, of turnover for firms specialised in nuclear maintenance or in the fuel cycle). It highlights recent events for companies of the sector: takeovers, investments, restructuring, introduction of new products, and so on. It proposes a sector-based dashboard which contains all the critical figures useful to analyse the sector situation (activity determining factors, key figures for the sector and its environment). The annual report proposes a general presentation of the sector (determining factors of the activity, operated nuclear plants in the world, nuclear power production in the world, uranium production and consumption in the world, maintenance and improvement expenses on nuclear plants, electric power consumption and shares in power generation by different sources in France), an analysis of the evolution of the sector activity (trends, indicators, financial performance of actors in the maintenance of nuclear plants), an overview of important issues for the profession (growth issue despite the maturity of the French market, implications of intensification of foreign competition, of higher safety requirements, and of a decrease of nuclear energy profitability), and an analysis of the sector economic structure (turnovers, personnel, position of France among world exporters, equipment export structure, key figures for nuclear maintenance). The last part proposes presentations of 20 French actors and data and information sheets for 10

  18. Implications of the new ICRP recommendations for the management of post-accidental situations

    International Nuclear Information System (INIS)

    Coulon, R.; Kelly, N.

    1992-01-01

    From an analysis of the new ICRP recommendations in relation with the management of post-accidental situations, there appears that no significant changes in comparison with the present situation will result. The consequences are rather an attempt to further clarify and justify the way in which the system of radiation protection applies to such situations, corresponding clearly to 'intervention situation', especially: - the use of the justification and optimization principles for the decision of implementing a protective measure. - the use of 'intervention levels' instead of individual 'dose limits'. In addition, and although there is no link at all between the dose limits applying in 'practices situations' and the intervention levels, the increase of risk factors could also result in a change of intervention levels. (author)

  19. Fuzzy logic as support for security and safety solution in soft targets

    Directory of Open Access Journals (Sweden)

    Ďuricová Lucia

    2016-01-01

    Full Text Available Security and safety situations in objects, which are categorized as soft targets, is difficult. The current solving is based on several different type of solving. Soft targets are specific objects, and it requires special software solution. The proposal is based on fuzzy logic. Fuzzy logic could apply more expert’s knowledges and it could help owners and managers with adequate responses in critical situation, and also definition of adequate preventive actions. System solving could help effectivity of proposed measures. The decision making is based on this fuzzy logic support and aim is explained in paper.

  20. Beyond typing and grading: target analysis in individualized therapy as a new challenge for tumour pathology.

    Science.gov (United States)

    Kreipe, Hans H; von Wasielewski, Reinhard

    2007-01-01

    In order to bring about its beneficial effects in oncology, targeted therapy depends on accurate target analysis. Whether cells of a tumour will be sensitive to a specific treatment is predicted by the detection of appropriate targets in cancer tissue by immunohistochemistry or molecular methods. In most instances this is performed by histopathologists. Reliability and reproducibility of tissue-based target analysis in histopathology require novel measures of quality assurance by internal and external controls. As a model for external quality assurance in targeted therapy an annual inter-laboratory trial has been set up in Germany applying tissue arrays with up to 60 mammary cancer samples which are tested by participants for expression of HER2/neu and steroid hormone receptors.

  1. Problem situations in management activity

    OpenAIRE

    N.A. DUBINKO

    2009-01-01

    This article reviews contemporary methodological and theoretical approaches to the problem situations in management activity. Revealed and analyzed the types of problem situations managers dealing with in their activity. Rank correlation of problem situations shows distinctions depending on management work experience. Revealed gender distinctions in the managers' ideas of management problems.

  2. Chinanteco children’s silences in different classroom situations

    Directory of Open Access Journals (Sweden)

    Valeria Rebolledo Angulo

    2016-01-01

    Full Text Available This article analyzes, from an ethnographic perspective and a sociocultural framework, the construction of silences in the interaction between students and teachers in a multilingual classroom situation in an indigenous community in méxico. the analysis reveals how the silence of the chinanteco speaking children when asked to answer certain questions in class is not always due to their failure to understand spoken and written spanish that is used in class. their silences are responses taking different meanings in specific situations. the silence of the children can be a way of resisting, a way of hiding, and, sometimes, their voices are silenced.

  3. An approach for evaluating expert performance in emergency situations

    International Nuclear Information System (INIS)

    Ujita, Hiroshi; Kawano, Ryutaro; Yoshimura, Sandanori

    1995-01-01

    To understand expert behavior and define what constitutes good performance in emergency situations in huge and complex plants, human performance evaluation should be made from viewpoints of not only error, but also various cognitive, psychological, and behavioral characteristics. Quantitative and qualitative measures of human performance are proposed for both individual operators and crews, based on the operator performance analysis experiment, among which cognitive and behavioral aspects are the most important. Operator performance should be further analyzed experimentally from the cognitive and behavioral viewpoints, using an evaluation based on various gross indexes considering operator's tasks which should be done in response to plant situations

  4. A Framework for Achieving Situational Awareness during Crisis based on Twitter Analysis

    Science.gov (United States)

    Zielinski, Andrea; Tokarchuk, Laurissa; Middleton, Stuart; Chaves, Fernando

    2013-04-01

    Decision Support Systems for Natural Crisis Management increasingly employ Web 2.0 and 3.0 technologies for future collaborative decision making, including the use of social networks like Twitter. However, human sensor data is not readily accessible and interpretable, since the texts are unstructured, noisy and available in various languages. The present work focusses on the detection of crisis events in a multilingual setting as part of the FP7-funded EU project TRIDEC and is motivated by the goal to establish a Tsunami warning system for the Mediterranean. It is integrated into a dynamic spatial-temporal decision making component with a command and control unit's graphical user interface that presents all relevant information to the human operator to support critical decision-support. To this end, a tool for the interactive visualization of geospatial data is implemented: All tweets with an exact timestamp or geo-location are monitored on the map in real-time so that the operator on duty can get an overall picture of the situation. Apart from the human sensor data, the seismic sensor data will appear also on the same screen. Signs of abnormal activity from twitter usage in social networks as well as in sensor networks devices can then be used to trigger official warning alerts according to the CAP message standard. Whenever a certain threshold of relevant tweets in a HASC region (Hierarchical Administrative Subdivision Code) is exceeded, the twitter activity in this administrative region will be shown on a map. We believe that the following functionalities are crucial for monitoring crisis, making use of text mining and network analysis techniques: Focussed crawling, trustworthyness analysis geo-parsing, and multilingual tweet classification. In the first step, the Twitter Streaming API accesses the social data, using an adaptive keyword list (focussed crawling). Then, tweets are filtered and aggregated to form counts for a certain time-span (e.g., an interval of

  5. Correlative Raman spectroscopy and focused ion beam for targeted phase boundary analysis of titania polymorphs

    Energy Technology Data Exchange (ETDEWEB)

    Mangum, John S.; Chan, Lisa H.; Schmidt, Ute; Garten, Lauren M.; Ginley, David S.; Gorman, Brian P.

    2018-05-01

    Site-specific preparation of specimens using focused ion beam instruments for transmission electron microscopy is at the forefront of targeting regions of interest for nanoscale characterization. Typical methods of pinpointing desired features include electron backscatter diffraction for differentiating crystal structures and energy-dispersive X-Ray spectroscopy for probing compositional variations. Yet there are situations, notably in the titanium dioxide system, where these techniques can fail. Differentiating between the brookite and anatase polymorphs of titania is either excessively laborious or impossible with the aforementioned techniques. However, due to differences in bonding structure, Raman spectroscopy serves as an ideal candidate for polymorph differentiation. In this work, a correlative approach utilizing Raman spectroscopy for targeted focused ion beam specimen preparation was employed. Dark field imaging and diffraction in the transmission electron microscope confirmed the region of interest located via Raman spectroscopy and demonstrated the validity of this new method. Correlative Raman spectroscopy, scanning electron microscopy, and focused ion beam is shown to be a promising new technique for identifying site-specific preparation of nanoscale specimens in cases where conventional approaches do not suffice.

  6. Perspective and predictive information in the cockpit as a target acquisition aid

    NARCIS (Netherlands)

    Breda, L. van

    1998-01-01

    In two flight simulation experiments, the potential benefits of 3D perspective) radar displays for situational awareness support were investigated. In the experimental set-up, a target acquisition task was employed in which subjects, flying a fighter aircraft, were required to locate a target that

  7. Deterministic and stochastic analysis of alternative climate targets under differentiated cooperation regimes

    International Nuclear Information System (INIS)

    Loulou, Richard; Labriet, Maryse; Kanudia, Amit

    2009-01-01

    This article analyzes the feasibility of attaining a variety of climate targets during the 21st century, under alternative cooperation regimes by groups of countries. Five climate targets of increasing severity are analyzed, following the EMF-22 experiment. Each target is attempted under two cooperation regimes, a First Best scenario where all countries fully cooperate from 2012 on, and a Second Best scenario where the World is partitioned into three groups, and each group of countries enters the cooperation at a different date, and implement emission abatement actions in a progressive manner, once in the coalition. The resulting ten combinations are simulated via the ETSAP-TIAM technology based, integrated assessment model. In addition to the 10 separate case analyses, the article proposes a probabilistic treatment of three targets under the First Best scenario, and shows that the three forcing targets may in fact be interpreted as a single target on global temperature change, while assuming that the climate sensitivity C s is uncertain. It is shown that such an interpretation is possible only if the probability distribution of C s is carefully chosen. The analysis of the results shows that the lowest forcing level is unattainable unless immediate coordinated action is undertaken by all countries, and even so only at a high global cost. The middle and the high forcing levels are feasible at affordable global costs, even under the Second Best scenario. Another original contribution of this article is to explain why certain combinations of technological choices are made by the model, and in particular why the climate target clearly supersedes the usually accepted objective of improving energy efficiency. The analysis shows that under some climate targets, it is not optimal to improve energy efficiency, but rather to take advantage of certain technologies that help to reach the climate objective, but that happen to be less energy efficient than even the technologies

  8. Integrative Analysis of CRISPR/Cas9 Target Sites in the Human HBB Gene

    Directory of Open Access Journals (Sweden)

    Yumei Luo

    2015-01-01

    Full Text Available Recently, the clustered regularly interspaced short palindromic repeats (CRISPR system has emerged as a powerful customizable artificial nuclease to facilitate precise genetic correction for tissue regeneration and isogenic disease modeling. However, previous studies reported substantial off-target activities of CRISPR system in human cells, and the enormous putative off-target sites are labor-intensive to be validated experimentally, thus motivating bioinformatics methods for rational design of CRISPR system and prediction of its potential off-target effects. Here, we describe an integrative analytical process to identify specific CRISPR target sites in the human β-globin gene (HBB and predict their off-target effects. Our method includes off-target analysis in both coding and noncoding regions, which was neglected by previous studies. It was found that the CRISPR target sites in the introns have fewer off-target sites in the coding regions than those in the exons. Remarkably, target sites containing certain transcriptional factor motif have enriched binding sites of relevant transcriptional factor in their off-target sets. We also found that the intron sites have fewer SNPs, which leads to less variation of CRISPR efficiency in different individuals during clinical applications. Our studies provide a standard analytical procedure to select specific CRISPR targets for genetic correction.

  9. TYPOLOGY OF COUNTRIES OF THE WORLD ACCORDING TO THE STATE OF FOOD SITUATION

    Directory of Open Access Journals (Sweden)

    Małgorzata Kołodziejczak

    2016-06-01

    Full Text Available The aim of the paper was to isolate, from countries where there is the biggest problem of malnutrition, groups which are similar according to the food situation. The research was based on the data of the Food and Agriculture Organization of the United Nations (FAO. The analysis covered 115 countries, where according to the FAO there is the highest level of malnutrition. The method of comparative analysis was used in the research and the process of grouping of countries according to the determinants of food situation was conducted with the use of cluster analysis. The research applied to the period 2012-2014. The typology of the countries let us to identify the most important factors determining the food situation in each cluster. There are historical events, national wealth or poverty which was accumulated over the time, natural conditions, as well as cultural and political conditions. Examples of relatively rich countries, where the malnutrition problem also appears, indicate the importance of income inequality.

  10. Signaling threat: how situational cues affect women in math, science, and engineering settings.

    Science.gov (United States)

    Murphy, Mary C; Steele, Claude M; Gross, James J

    2007-10-01

    This study examined the cues hypothesis, which holds that situational cues, such as a setting's features and organization, can make potential targets vulnerable to social identity threat. Objective and subjective measures of identity threat were collected from male and female math, science, and engineering (MSE) majors who watched an MSE conference video depicting either an unbalanced ratio of men to women or a balanced ratio. Women who viewed the unbalanced video exhibited more cognitive and physiological vigilance, and reported a lower sense of belonging and less desire to participate in the conference, than did women who viewed the gender-balanced video. Men were unaffected by this situational cue. The implications for understanding vulnerability to social identity threat, particularly among women in MSE settings, are discussed.

  11. Situational interest in engineering design activities

    DEFF Research Database (Denmark)

    Dohn, Niels Bonderup

    2013-01-01

    The aim of the present mixed-method study was to investigate task-based situational interest of sixth grade students (n=46), between 12 and 14 years old, during an eight-week engineering design programme in a Science & Technology-class. Students’ interests were investigated by means...... of a descriptive interpretative analysis of qualitative data from classroom observations and informal interviews. The analysis was complemented by a self-report survey to validate findings and determine prevalence. The analysis revealed four main sources of interest: designing inventions, trial......-and-error experimentation, achieved functionality of invention, and collaboration. These sources differ in terms of stimuli factors, such as novelty, autonomy (choice), social involvement, self-generation of interest, and task goal orientation. The study shows that design tasks stimulated interest, but only to the extent...

  12. Extending in silico mechanism-of-action analysis by annotating targets with pathways: application to cellular cytotoxicity readouts.

    Science.gov (United States)

    Liggi, Sonia; Drakakis, Georgios; Koutsoukas, Alexios; Cortes-Ciriano, Isidro; Martínez-Alonso, Patricia; Malliavin, Thérèse E; Velazquez-Campoy, Adrian; Brewerton, Suzanne C; Bodkin, Michael J; Evans, David A; Glen, Robert C; Carrodeguas, José Alberto; Bender, Andreas

    2014-01-01

    An in silico mechanism-of-action analysis protocol was developed, comprising molecule bioactivity profiling, annotation of predicted targets with pathways and calculation of enrichment factors to highlight targets and pathways more likely to be implicated in the studied phenotype. The method was applied to a cytotoxicity phenotypic endpoint, with enriched targets/pathways found to be statistically significant when compared with 100 random datasets. Application on a smaller apoptotic set (10 molecules) did not allowed to obtain statistically relevant results, suggesting that the protocol requires modification such as analysis of the most frequently predicted targets/annotated pathways. Pathway annotations improved the mechanism-of-action information gained by target prediction alone, allowing a better interpretation of the predictions and providing better mapping of targets onto pathways.

  13. Energy situation - Forth quarter 2016. Energy situation October 2016; Energy situation November 2016; Energy situation December 2016

    International Nuclear Information System (INIS)

    Guggemos, Fabien; Misak, Evelyne; Mombel, David; Moreau, Sylvain

    2017-02-01

    This publication presents, first, a quarterly report of the French energy situation: primary energy consumption, energy independence and CO_2 emissions, national production, imports, exports, energy costs, average and spot prices. Data are presented separately for solid mineral fuels, petroleum products, natural gas and electricity. Month-to-month details are summarized in a second part, in the form of tables and graphs

  14. Energy situation - First quarter 2017. Energy situation January 2017; Energy situation February 2017; Energy situation March 2017

    International Nuclear Information System (INIS)

    Guggemos, Fabien; Misak, Evelyne; Mombel, David; Moreau, Sylvain

    2017-05-01

    This publication presents, first, a quarterly report of the French energy situation: primary energy consumption, energy independence and CO_2 emissions, national production, imports, exports, energy costs, average and spot prices. Data are presented separately for solid mineral fuels, petroleum products, natural gas and electricity. Month-to-month details are summarized in a second part, in the form of tables and graphs

  15. Stakeholder analysis and mapping as targeted communication strategy.

    Science.gov (United States)

    Shirey, Maria R

    2012-09-01

    This department highlights change management strategies that may be successful in strategically planning and executing organizational change initiatives. With the goal of presenting practical approaches helpful to nurse leaders advancing organizational change, content includes evidence-based projects, tools, and resources that mobilize and sustain organizational change initiatives. In this article, the author highlights the importance of stakeholder theory and discusses how to apply the theory to conduct a stakeholder analysis. This article also provides an explanation of how to use related stakeholder mapping techniques with targeted communication strategies.

  16. Situational theory of leadership.

    Science.gov (United States)

    Waller, D J; Smith, S R; Warnock, J T

    1989-11-01

    The situational theory of leadership and the LEAD instruments for determining leadership style are explained, and the application of the situational leadership theory to the process of planning for and implementing organizational change is described. Early studies of leadership style identified two basic leadership styles: the task-oriented autocratic style and the relationship-oriented democratic style. Subsequent research found that most leaders exhibited one of four combinations of task and relationship behaviors. The situational leadership theory holds that the difference between the effectiveness and ineffectiveness of the four leadership styles is the appropriateness of the leader's behavior to the particular situation in which it is used. The task maturity of the individual or group being led must also be accounted for; follower readiness is defined in terms of the capacity to set high but attainable goals, willingness or ability to accept responsibility, and possession of the necessary education or experience for a specific task. A person's leadership style, range, and adaptability can be determined from the LEADSelf and LEADOther questionnaires. By applying the principles of the situational leadership theory and adapting their managerial styles to specific tasks and levels of follower maturity, the authors were successful in implementing 24-hour pharmacokinetic dosing services provided by staff pharmacists with little previous experience in clinical services. The situational leadership model enables a leader to identify a task, set goals, determine the task maturity of the individual or group, select an appropriate leadership style, and modify the style as change occurs. Pharmacy managers can use this model when implementing clinical pharmacy services.

  17. Molecular Targets for PET Imaging of Activated Microglia: The Current Situation and Future Expectations.

    Science.gov (United States)

    Tronel, Claire; Largeau, Bérenger; Santiago Ribeiro, Maria Joao; Guilloteau, Denis; Dupont, Anne-Claire; Arlicot, Nicolas

    2017-04-11

    Microglia, as cellular mediators of neuroinflammation, are implicated in the pathogenesis of a wide range of neurodegenerative diseases. Positron emission tomography (PET) imaging of microglia has matured over the last 20 years, through the development of radiopharmaceuticals targeting several molecular biomarkers of microglial activation and, among these, mainly the translocator protein-18 kDa (TSPO). Nevertheless, current limitations of TSPO as a PET microglial biomarker exist, such as low brain density, even in a neurodegenerative setting, expression by other cells than the microglia (astrocytes, peripheral macrophages in the case of blood brain barrier breakdown), genetic polymorphism, inducing a variation for most of TSPO PET radiopharmaceuticals' binding affinity, or similar expression in activated microglia regardless of its polarization (pro- or anti-inflammatory state), and these limitations narrow its potential interest. We overview alternative molecular targets, for which dedicated radiopharmaceuticals have been proposed, including receptors (purinergic receptors P2X7, cannabinoid receptors, α7 and α4β2 nicotinic acetylcholine receptors, adenosine 2A receptor, folate receptor β) and enzymes (cyclooxygenase, nitric oxide synthase, matrix metalloproteinase, β-glucuronidase, and enzymes of the kynurenine pathway), with a particular focus on their respective contribution for the understanding of microglial involvement in neurodegenerative diseases. We discuss opportunities for these potential molecular targets for PET imaging regarding their selectivity for microglia expression and polarization, in relation to the mechanisms by which microglia actively participate in both toxic and neuroprotective actions in brain diseases, and then take into account current clinicians' expectations.

  18. Building shared situational awareness in surgery through distributed dialog

    Directory of Open Access Journals (Sweden)

    Gillespie BM

    2013-03-01

    Full Text Available Brigid M Gillespie,1 Karleen Gwinner,2 Nicole Fairweather,3 Wendy Chaboyer41NHMRC Research Centre for Clinical Excellence in Nursing Interventions for Hospitalised Patients (NCREN and Research Centre for Clinical and Community Practice Innovation (RCCCPI, Griffith Health Institute, Griffith University, Queensland, 2Griffith Centre for Cultural Research, Griffith University, Queensland, 3Department of Anaesthesiology, Princess Alexandra Hospital, Queensland, Australia, 4Excellence in Nursing Interventions for Hospitalized Patients (NCREN Research Centre for Clinical and Community Practice INHMRC Centre of Research Innovation (RCCCPI, Griffith Health Institute, Griffith University Queensland, AustraliaBackground: Failure to convey time-critical information to team members during surgery diminishes members' perception of the dynamic information relevant to their task, and compromises shared situational awareness. This research reports the dialog around clinical decisions made by team members in the time-pressured and high-risk context of surgery, and the impact of these communications on shared situational awareness.Methods: Fieldwork methods were used to capture the dynamic integration of individual and situational elements in surgery that provided the backdrop for clinical decisions. Nineteen semistructured interviews were performed with 24 participants from anesthesia, surgery, and nursing in the operating rooms of a large metropolitan hospital in Queensland, Australia. Thematic analysis was used.Results: The domain "coordinating decisions in surgery" was generated from textual data. Within this domain, three themes illustrated the dialog of clinical decisions, ie, synchronizing and strategizing actions, sharing local knowledge, and planning contingency decisions based on priority.Conclusion: Strategies used to convey decisions that enhanced shared situational awareness included the use of "self-talk", closed-loop communications, and

  19. Dynamic analysis of the Nova Target Chamber to assess alignment errors due to ambient noise

    International Nuclear Information System (INIS)

    McCallen, D.B.; Murray, R.C.

    1984-01-01

    We performed a study to determine the dynamic behavior of the Nova Target Chamber. We conducted a free vibration analysis to determine the natural frequencies of vibration and the corresponding modeshapes of the target chamber. Utilizing the free vibration results, we performed forced vibration analysis to predict the displacements of the chamber due to ambient vibration. The input support motion for the forced vibration analysis was defined by a white noise acceleration spectrum which was based on previous measurements of ground noise near the Nova site. A special purpose computer program was prepared to process the results of the forced vibration analysis. The program yields distances by which the lines of sight of the various laser beams miss the target as a result of ambient vibrations. We also performed additional estimates of miss distance to provide bounds on the results. A description of the finite element model of the chamber, the input spectrum, and the results of the analyses are included

  20. NEEDS ANALYSIS IN ENGLISH FOR SPECIFIC PURPOSES

    Directory of Open Access Journals (Sweden)

    SIMION MINODORA OTILIA

    2015-03-01

    Full Text Available Needs analysis is considered to be the cornerstone of English for Specific Purposes(ESP. The concept of Needs analysis has been different along the decades. At the initial stages of ESP( the 1960s and early 1970s, needs analysis consisted in assessing the communicative needs of the learners and the techniques of achieving specific teaching objectives. Nowadays, the tasks of needs analysis is much more complex: it aims at collecting information about the learners and at defining the target situation and environment of studying ESP.

  1. Competitive situation of clothing and textile industry

    OpenAIRE

    Jansevičiūtė, Daina

    2010-01-01

    This paper is up for discussing the composed competitive situation of Lithuanian clothing and textile industry. Author concisely proposes aspects of competitive ability conception, explores the main statistical information illustrating importance of clothing and textile industry in all manufacturing and economics. Willing to accomplish a statistical data analysis of trade clothing and textile industry competitors and advantages which they have and which influence Lithuanian clothing and texti...

  2. Applying Cognitive Fusion to Space Situational Awareness

    Science.gov (United States)

    Ingram, S.; Shaw, M.; Chan, M.

    With recent increases in capability and frequency of rocket launches from countries across the world, maintaining a state-of-the-art Space Situational Awareness model is all the more necessary. We propose a fusion of real-time, natural language processing capability provided by IBM cognitive services with ground-based sensor data of positions and trajectories of satellites in all earth orbits. We believe such insight provided by cognitive services could help determine context to missile launches, help predict when a satellite of interest could be in danger, either by accident or by intent, and could alert interested parties to the perceived threat. We seek to implement an improved Space Situational Awareness model by developing a dynamic factor graph model informed by the fusion of ground-based ”structured” sensor data with ”unstructured” data from the public domain, such as news articles, blogs, and social media, in real time. To this end, we employ IBM’s Cognitive services, specifically, Watson Discovery. Watson Discovery allows real-time natural language processing of text including entity extraction, keyword search, taxonomy classification, concept tagging, relation extraction, sentiment analysis, and emotion analysis. We present various scenarios that demonstrate the utility of this new Space Situational Awareness model, each of which combine past structured information with related open source data. We demonstrate that should the model come to estimate a satellite is ”of interest”, it will indicate it as so, based on the most pertinent data, such as a reading from a sensor or by information available online. We present and discuss the most recent iterations of the model for satellites currently available on Space-Track.org.

  3. Sound Art Situations

    DEFF Research Database (Denmark)

    Krogh Groth, Sanne; Samson, Kristine

    2017-01-01

    and combine theories from several fields. Aspects of sound art studies, performance studies and contemporary art studies are presented in order to theoretically explore the very diverse dimensions of the two sound art pieces: Visual, auditory, performative, social, spatial and durational dimensions become......This article is an analysis of two sound art performances that took place June 2015 in outdoor public spaces in the social housing area Urbanplanen in Copenhagen, Denmark. The two performances were On the production of a poor acoustics by Brandon LaBelle and Green Interactive Biofeedback...... Environments (GIBE) by Jeremy Woodruff. In order to investigate the complex situation that arises when sound art is staged in such contexts, the authors of this article suggest exploring the events through approaching them as ‘situations’ (Doherty 2009). With this approach it becomes possible to engage...

  4. Oceanographic Data Repositories: An Analysis of the International Situation

    Directory of Open Access Journals (Sweden)

    Fabiano Couto Corrêa da Silva

    2017-04-01

    Full Text Available The preservation and organization of oceanographic research data enables the scientific community to consult and reuse information of different kinds, and this is made possible by the repositories, meaning the services that facilitate data storage and dissemination. This paper reviews the current situation of oceanographic data repositories across different countries and evaluates them according to a series of indicators. The writers propose that although interest in storing and reusing oceanographic data has increased in recent years, the repositories are still in the process of developing their systems for processing, disseminating and reusing data. The repositories also differ in terms of architecture and the organizational level of the content they offer.

  5. Drug target mining and analysis of the Chinese tree shrew for pharmacological testing.

    Directory of Open Access Journals (Sweden)

    Feng Zhao

    Full Text Available The discovery of new drugs requires the development of improved animal models for drug testing. The Chinese tree shrew is considered to be a realistic candidate model. To assess the potential of the Chinese tree shrew for pharmacological testing, we performed drug target prediction and analysis on genomic and transcriptomic scales. Using our pipeline, 3,482 proteins were predicted to be drug targets. Of these predicted targets, 446 and 1,049 proteins with the highest rank and total scores, respectively, included homologs of targets for cancer chemotherapy, depression, age-related decline and cardiovascular disease. Based on comparative analyses, more than half of drug target proteins identified from the tree shrew genome were shown to be higher similarity to human targets than in the mouse. Target validation also demonstrated that the constitutive expression of the proteinase-activated receptors of tree shrew platelets is similar to that of human platelets but differs from that of mouse platelets. We developed an effective pipeline and search strategy for drug target prediction and the evaluation of model-based target identification for drug testing. This work provides useful information for future studies of the Chinese tree shrew as a source of novel targets for drug discovery research.

  6. Situative Space Tracking within Smart Environments

    DEFF Research Database (Denmark)

    Surie, Dipak; Jäckel, Florian; Janlert, Lars-Erik

    2010-01-01

    This paper describes our efforts in modeling and tracking a human agent’s situation based on his/her possibilities to perceive and act upon objects (both physical and virtual) within smart environments. A Situative Space Model is proposed. WLAN signal-strength-based situative space tracking syste......-laboratory smart home environment where a global precision of 83.4% and a global recall of 88.6% were obtained.......This paper describes our efforts in modeling and tracking a human agent’s situation based on his/her possibilities to perceive and act upon objects (both physical and virtual) within smart environments. A Situative Space Model is proposed. WLAN signal-strength-based situative space tracking system...

  7. Prediction methodologies for target scene generation in the aerothermal targets analysis program (ATAP)

    Science.gov (United States)

    Hudson, Douglas J.; Torres, Manuel; Dougherty, Catherine; Rajendran, Natesan; Thompson, Rhoe A.

    2003-09-01

    The Air Force Research Laboratory (AFRL) Aerothermal Targets Analysis Program (ATAP) is a user-friendly, engineering-level computational tool that features integrated aerodynamics, six-degree-of-freedom (6-DoF) trajectory/motion, convective and radiative heat transfer, and thermal/material response to provide an optimal blend of accuracy and speed for design and analysis applications. ATAP is sponsored by the Kinetic Kill Vehicle Hardware-in-the-Loop Simulator (KHILS) facility at Eglin AFB, where it is used with the CHAMP (Composite Hardbody and Missile Plume) technique for rapid infrared (IR) signature and imagery predictions. ATAP capabilities include an integrated 1-D conduction model for up to 5 in-depth material layers (with options for gaps/voids with radiative heat transfer), fin modeling, several surface ablation modeling options, a materials library with over 250 materials, options for user-defined materials, selectable/definable atmosphere and earth models, multiple trajectory options, and an array of aerodynamic prediction methods. All major code modeling features have been validated with ground-test data from wind tunnels, shock tubes, and ballistics ranges, and flight-test data for both U.S. and foreign strategic and theater systems. Numerous applications include the design and analysis of interceptors, booster and shroud configurations, window environments, tactical missiles, and reentry vehicles.

  8. Gynaecology – Quo vadis? Situation Analysis, National and International Perspectives

    Science.gov (United States)

    Brucker, S. Y.; Simoes, E.; Wallwiener, D.

    2014-01-01

    In a large and heavily networked specialty like gynaecology it is a particular challenge with regard to future status to achieve excellent patient care, research and teaching. At the same time not only hospitals but also research facilities are experiencing increasing pressure from performance and competition sides in terms of survival and further development on the clinical, scientific and economic fronts. The numerous changes, including paradigm shifts, in medicine, society, the health-care system and scientific innovations present new challenges to the specialty. This leads to questions about priority, problem areas and weaknesses as well as to new opportunities for the field and the overall question if it will be possible to meet the paradigm shifts and problems by the creation of new structures. In the light of the need for and the potential of design measures, this article presents a SWOT analysis of the specialtyʼs situation as a whole and in particular for gynaecology in German universities. One sees additional demands that add up to an expansion of the tasks. At the same time the shortage of new recruits becomes apparent. A broadening of the perspectives on womenʼs health and individualised medicine come into focus. Partial solutions include new supporting structures, capacity measurements as well as even structural options. In particular, the department structure, that is common abroad, opens an opportunity for specialisation while maintaining unity for a broader further training and strengthened research. Chances and strengths of the specialty are especially effective in coordinated and concerted activities. PMID:25568466

  9. Targeted Phototherapy (newer phototherapy

    Directory of Open Access Journals (Sweden)

    Zonunsanga

    2015-04-01

    Full Text Available Conventional phototherapy uses a whole body cabinet or body part machine such as hand, foot or scalp machines. They have many disadvantages due to which new phototherapy technique was then developed to overcome this situation. This new technique is called targeted phototherapy which includes excimer laser, intense pulse light system (IPL, photodynamic therapy and ultraviolet (UV light source with a sophisticated delivery system which is easy to be operated by hands. The mechanisms of action of targeted phototherapy systems are similar to those in conventional UVB/UVA therapy. They have many advantages like less chances of side effects, avoidance of exposure of unnecessary sites, faster response, shortening of the duration of treatments. But they have disadvantages like high costs and inability to use for extensive areas. This review article discusses targeted phototherapy in considerable to the mechanism of actions and advantages and disadvantages in comparison to the conventional phototherapy.

  10. Alcohol-related memory associations in positive and negative affect situations: drinking motives, working memory capacity, and prospective drinking.

    Science.gov (United States)

    Salemink, Elske; Wiers, Reinout W

    2014-03-01

    Although studies on explicit alcohol cognitions have identified positive and negative reinforcing drinking motives that are differentially related to drinking indices, such a distinction has received less attention in studies on implicit cognitions. An alcohol-related Word-Sentence Association Task was used to assess implicit alcohol-related memory associations in positive and negative affect situations in 92 participants. Results revealed that enhancement motives were specifically associated with the endorsement of alcohol words in positive affect situations and coping motives were associated with the endorsement of alcohol words in negative affect situations. Furthermore, alcohol associations in positive affect situations predicted prospective alcohol use and number of binges, depending on levels of working memory capacity. The current findings shed more light on the underpinnings of alcohol use and suggest that implicit memory processes and working memory capacity might be important targets for intervention.

  11. Impact of water drops on small targets

    Science.gov (United States)

    Rozhkov, A.; Prunet-Foch, B.; Vignes-Adler, M.

    2002-10-01

    The collision of water drops against small targets was studied experimentally by means of a high-speed photography technique. The drop impact velocity was about 3.5 m/s. Drop diameters were in the range of 2.8-4.0 mm. The target was a stainless steel disk of 3.9 mm diameter. The drop spread beyond the target like a central cap surrounded by a thin, slightly conical lamella bounded by a thicker rim. By mounting a small obstacle near the target, surface-tension driven Mach waves in the flowing lamella were generated, which are formally equivalent to the familiar compressibility driven Mach waves in gas dynamics. From the measurement of the Mach angle, the values of some flow parameters could be obtained as functions of time, which provided insight into the flow structure. The liquid flowed from the central cap to the liquid rim through the thin lamella at constant momentum flux. At a certain stage of the process, most of the liquid accumulated in the rim and the internal part of the lamella became metastable. In this situation, a rupture wave propagating through the metastable internal part of the lamella caused the rim to retract while forming outwardly directed secondary jets. The jets disintegrated into secondary droplets due to the Savart-Plateau-Rayleigh instability. Prior to the end of the retraction, an internal circular wave of rupture was formed. It originated at the target and then it propagated to meet the retracting rim. Their meeting resulted in a crown of tiny droplets. A theoretical analysis of the ejection process is proposed.

  12. Fukushima 2014: situation and perspectives in 10 questions

    International Nuclear Information System (INIS)

    Barre, Bertrand; Perves, Jean-Pierre; Xerri, Christophe; Clement, Thibault; Le Ngoc, Boris; Sorin, Francis

    2014-01-01

    Illustrated by maps, data graphs and tables, this article proposes answers to ten questions related to the situation and to the perspectives of evolution for the Fukushima power plant and its region. Is there any progress in the accident analysis and understanding? What about safety arrangements implemented in France in the light of lessons learned from the accident? What about the situation on the plant site? Is the site still releasing radioactivity towards the outside, the region and the ocean (atmospheric releases, contaminated liquid releases, sea water contamination, storage and processing of huge quantities of water)? What about working conditions and the situation of personnel working on the site? How is the dismantling of equipment prepared and started? What about decontamination works in the territories, i.e. evacuation zone and beyond (existence of different decontamination areas, performed and started decontamination works, residue storage site, and implemented decontamination methods)? What about the coming back of populations to their evacuated dwellings (on a short, medium or long term)? What are the last results of studies of the health impact of the accident in the present period and on a longer term? What about the energy situation in Japan and will the electronuclear program be launched again on a large scale (possible restart of some reactors in 2014, dramatic consequences for the Japanese economy)?

  13. Progranulin as a therapeutic target for dementia.

    Science.gov (United States)

    Galimberti, Daniela; Fenoglio, Chiara; Scarpini, Elio

    2018-06-22

    Progranulin (PGRN) is an acrosomal glycoprotein that is synthesized during spermatogenesis. It is overexpressed in tumors and has anti-inflammatory properties. The protein may be cleaved into granulins which display pro-inflammatory properties. In 2006, mutations in progranulin gene (GRN) that cause haploinsufficiency were found in familial cases of frontotemporal dementia (FTD). Patients with null mutations in GRN display very low-plasma PGRN levels; this analysis is useful for identifying mutation carriers, independent of the clinical presentation, and in those before the appearance of symptoms. Areas covered: Here, we review the current knowledge of PGRN physiological functions and GRN mutations associated with FTD; we also summarize state of the art clinical trials and those compounds able to replace PGRN loss in preclinical models. Expert opinion: PGRN represents a promising therapeutic target for FTD. Cohorts suitable for treatment, ideally at the preclinical stage, where pathogenic mechanisms ongoing in the brain are targeted, are available. However, PGRN may have side effects, such as the risk of tumorigenesis, and the risk/benefit ratio of any intervention cannot be predicted. Furthermore, at present, the situation is complicated by the absence of adequate outcome measures.

  14. INTEGRATED ON-BOARD COMPUTING SYSTEMS: PRESENT SITUATION REVIEW AND DEVELOPMENT PROSPECTS ANALYSIS IN THE AVIATION INSTRUMENT-MAKING INDUSTRY

    Directory of Open Access Journals (Sweden)

    P. P. Paramonov

    2013-03-01

    Full Text Available The article deals with present situation review and analysis of development prospects for integrated on-board computing systems, used in the aviation instrument-making industry. The main attention is paid to the projects carried out in the framework of an integrated modular avionics. Hierarchical levels of module design, crates (onboard systems and aviation complexes are considered in detail. Examples of the existing products of our country and from abroad and their brief technical characteristics are given and voluminous bibliography on the subject matter as well.

  15. Theory of error for target factor analysis with applications to mass spectrometry and nuclear magnetic resonance spectrometry

    International Nuclear Information System (INIS)

    Malinowski, E.R.

    1978-01-01

    Based on the theory of error for abstract factor analysis described earlier, a theory of error for target factor analysis is developed. The theory shows how the error in the data matrix mixes with the error in the target test vector. The apparent error in a target test is found to be a vector sum of the real error in the target vector and the real error in the predicted vector. The theory predicts the magnitudes of these errors without requiring any a priori knowledge of the error in the data matrix or the target vector. A reliability function and a spoil function are developed for the purpose of assessing the validity and the worthiness of a target vector. Examples from model data, mass spectrometry and nuclear magnetic resonance spectrometry are presented. (Auth.)

  16. A Situational Maintenance Model

    DEFF Research Database (Denmark)

    Luxhoj, James T.; Thorsteinsson, Uffe; Riis, Jens Ove

    1997-01-01

    An overview of trend in maintenance management and presentation of a situational model and an analytical tools for identification of managerial efforts in maintenance.......An overview of trend in maintenance management and presentation of a situational model and an analytical tools for identification of managerial efforts in maintenance....

  17. Vulnerability Situations associated with Flash Flood Casualties in the United States

    Science.gov (United States)

    Terti, G.; Ruin, I.; Anquetin, S.; Gourley, J. J.

    2015-12-01

    In the United States (U.S.) flash flooding (FF hereafter) is one of the leading cause of weather-related deaths. Because FF events can be distinguished from riverine floods by their fast response to rainfall and resulting impacts signature, analyzing FF-specific impact datasets seems a good way to identify the juxtaposition of social and physical circumstances leading to those impacts. This communication focuses on conceptual and methodological developments allowing testing hypotheses on FF-specific vulnerability factors through the analysis of human impact datasets. We hypothesize that the intersection of the spatio-temporal context of the FF phenomena with the distribution of people and their characteristics across space and time reveals various paths of vulnerability through the expression of different accidents' circumstances (i.e., vehicle-related, inside buildings, open-air, campsites). We argue that vulnerability and the resulting impacts vary dynamically throughout the day according to the location/situation under concern. In order to test FF-specific contextual vulnerability factors at the scale of the continental US, 1075 fatalities reported between 1996 and 2014 in the Storm Data publication of the U.S. National Climatic Data Center (NCDC) are analyzed to statistically explore the timing, the duration and the location of the FF event, and the age and gender of the victims and the circumstance (i.e. location/activity) of their death. In this objective, a re-classification of the individual fatality circumstances and a discretization of the time in qualitative time-steps are performed to obtain possible trends and patterns in the occurrence of fatalities in certain circumstances and time (e.g., day vs night). The findings highlight the importance of situation-specific assessment of FF fatalities to guide the development of FF-specific vulnerability and impacts prediction modeling. Such analysis can provide valuable knowledge when the National Weather

  18. Pilots' Attention Distributions Between Chasing a Moving Target and a Stationary Target.

    Science.gov (United States)

    Li, Wen-Chin; Yu, Chung-San; Braithwaite, Graham; Greaves, Matthew

    2016-12-01

    Attention plays a central role in cognitive processing; ineffective attention may induce accidents in flight operations. The objective of the current research was to examine military pilots' attention distributions between chasing a moving target and a stationary target. In the current research, 37 mission-ready F-16 pilots participated. Subjects' eye movements were collected by a portable head-mounted eye-tracker during tactical training in a flight simulator. The scenarios of chasing a moving target (air-to-air) and a stationary target (air-to-surface) consist of three operational phases: searching, aiming, and lock-on to the targets. The findings demonstrated significant differences in pilots' percentage of fixation during the searching phase between air-to-air (M = 37.57, SD = 5.72) and air-to-surface (M = 33.54, SD = 4.68). Fixation duration can indicate pilots' sustained attention to the trajectory of a dynamic target during air combat maneuvers. Aiming at the stationary target resulted in larger pupil size (M = 27,105, SD = 6565), reflecting higher cognitive loading than aiming at the dynamic target (M = 23,864, SD = 8762). Pilots' visual behavior is not only closely related to attention distribution, but also significantly associated with task characteristics. Military pilots demonstrated various visual scan patterns for searching and aiming at different types of targets based on the research settings of a flight simulator. The findings will facilitate system designers' understanding of military pilots' cognitive processes during tactical operations. They will assist human-centered interface design to improve pilots' situational awareness. The application of an eye-tracking device integrated with a flight simulator is a feasible and cost-effective intervention to improve the efficiency and safety of tactical training.Li W-C, Yu C-S, Braithwaite G, Greaves M. Pilots' attention distributions between chasing a moving target and a stationary target. Aerosp Med

  19. Coupling analysis of the target temperature and thermal stress due to pulsed ion beam

    International Nuclear Information System (INIS)

    Yan Jie; Liu Meng; Lin Jufang; An Li; Long Xinggui

    2013-01-01

    Background: Target temperature has an important effect on the target life for the sealed neutron generator without cooling system. Purpose: To carry out the thermal-mechanical coupling analysis of the film-substrate target bombarded by the pulsed ion beam. Methods: The indirect coupling Finite Element Method (FEM) with a 2-dimensional time-space Gaussian axisymmetric power density as heat source was used to simulate the target temperature and thermal stress fields. Results: The effects of the target temperature and thermal stress fields under difference pulse widths and beam sizes were analyzed in terms of the FEM results. Conclusions: Combining with the temperature requirement and the thermal stress inducing film thermal mechanical destruction effect of the sealed neutron generator film-substrate targets, an optimized pulsed ion beam work status was proposed. (authors)

  20. A Task-Based Needs Analysis for Australian Aboriginal Students: Going beyond the Target Situation to Address Cultural Issues

    Science.gov (United States)

    Oliver, Rhonda; Grote, Ellen; Rochecouste, Judith; Exell, Michael

    2013-01-01

    While needs analyses underpin the design of second language analytic syllabi, the methodologies undertaken are rarely examined. This paper explores the value of multiple data sources and collection methods for developing a needs analysis model to enable vocational education and training teachers to address the needs of Australian Aboriginal…

  1. [Situational panorama of Mexico against the chikungunya virus pandemic].

    Science.gov (United States)

    Martínez-Sánchez, Abisai; Martínez-Ramos, Ericay Berenice; Chávez-Angeles, Manuel Gerardo

    2015-01-01

    Recent outbreaks of emerging diseases emphasize the vulnerability of health systems, as is the case of chikungunya fever. The wide geographical incidence of the virus in the last years requires alerting systems for the prevention, diagnosis, control and eradication of the disease. Given the ecological, epidemiological and socio-economic characteristic of Mexico, this disease affects directly or indirectly the health of the population and development of agricultural, livestock, industrial, fishing, oil and tourism activities in the country. Due to this situation it is essential to make a brief analysis on the main clinical data, epidemiological and preventive measures with which our country counts with to confront the situation.

  2. Target normal sheath acceleration analytical modeling, comparative study and developments

    International Nuclear Information System (INIS)

    Perego, C.; Batani, D.; Zani, A.; Passoni, M.

    2012-01-01

    Ultra-intense laser interaction with solid targets appears to be an extremely promising technique to accelerate ions up to several MeV, producing beams that exhibit interesting properties for many foreseen applications. Nowadays, most of all the published experimental results can be theoretically explained in the framework of the target normal sheath acceleration (TNSA) mechanism proposed by Wilks et al. [Phys. Plasmas 8(2), 542 (2001)]. As an alternative to numerical simulation various analytical or semi-analytical TNSA models have been published in the latest years, each of them trying to provide predictions for some of the ion beam features, given the initial laser and target parameters. However, the problem of developing a reliable model for the TNSA process is still open, which is why the purpose of this work is to enlighten the present situation of TNSA modeling and experimental results, by means of a quantitative comparison between measurements and theoretical predictions of the maximum ion energy. Moreover, in the light of such an analysis, some indications for the future development of the model proposed by Passoni and Lontano [Phys. Plasmas 13(4), 042102 (2006)] are then presented.

  3. Doses to radiation sensitive organs and structures located outside the radiotherapeutic target volume for four treatment situations

    International Nuclear Information System (INIS)

    Foo, M.L.; McCullough, E.C.; Foote, R.L.; Pisansky, T.M.; Shaw, E.G.

    1993-01-01

    This study documents dosage to radiation sensitive organs/structures located outside the radiotherapeutic target volume for four treatment situations: (a) head and neck, (b) brain (pituitary and temporal lobe), (c) breast and (d) pelvis. Clinically relevant treatment fields were simulated on a tissue-equivalent anthropomorphic phantom and subsequently irradiated with Cobalt-60 gamma rays, 6- and 18-MV x-ray beams. Thermoluminescent dosimeters and diodes were used to measure absorbed dose. The head and neck treatment resulted in significant doses of radiation to the lens and thyroid gland. The total treatment lens dose (300-400 cGy) could be cataractogenic while measured thyroid doses (1000-8000 cGy) have the potential of causing chemical hypothyroidism, thyroid neoplasms, Graves' disease and hyperparathyroidism. Total treatment retinal (400-700 cGy) and pituitary (460-1000 cGy) doses are below that considered capable of producing chronic disease. The pituitary treatment studied consisted of various size parallel opposed lateral and vertex fields (4 x 4 through 8 x 8 cm). The lens dose (40-200 cGy) with all field sizes is below those of clinical concern. Parotid doses (130-1200 cGy) and thyroid doses (350-600 cGy) are in a range where temporary xerostomia (parotid) and thyroid neoplasia development are a reasonable possibility. The retinal dose (4000 cGy) from the largest field size (8 x 8 cm 2 ) is in the range where retinopathy has been reported. The left temporal lobe treatment also used parallel opposed lateral and vertex fields (7 x 7 and 10 x 10 cm). Doses to the pituitary gland (5200-6200 cGy), both parotids (200-6900 cGy), left lens (200-300 cGy), and left retina (1700-4500 cGy) are capable of causing significant future clinical problems. Right-sided structures received insignificant doses. Secondary malignancies could result from the measured total treatment thyroid doses (670-980 cGy). 82 refs., 7 figs., 5 tabs

  4. Situational Interest in Engineering Design Activities

    Science.gov (United States)

    Bonderup Dohn, Niels

    2013-08-01

    The aim of the present mixed-method study was to investigate task-based situational interest of sixth grade students (n = 46), between 12 and 14 years old, during an eight-week engineering design programme in a Science & Technology-class. Students' interests were investigated by means of a descriptive interpretative analysis of qualitative data from classroom observations and informal interviews. The analysis was complemented by a self-report survey to validate findings and determine prevalence. The analysis revealed four main sources of interest: designing inventions, trial-and-error experimentation, achieved functionality of invention, and collaboration. These sources differ in terms of stimuli factors, such as novelty, autonomy (choice), social involvement, self-generation of interest, and task goal orientation. The study shows that design tasks stimulated interest, but only to the extent that students were able to self-regulate their learning strategies.

  5. Study on operator’s SA reliability in digital NPPs. Part 1: The analysis method of operator’s errors of situation awareness

    International Nuclear Information System (INIS)

    Li, Peng-cheng; Zhang, Li; Dai, Li-cao; Li, Xiao-Fang

    2017-01-01

    Highlights: • The model of ESA is established from an organization perspective, and it is new perspective. • The detailed classification system of ESA is developed based on the built ESA model. It is useful to identify the cause chain and root causes of organization causing ESA. • The analysis method of ESA is also constructed to guide the investigation of ESA event. A case study is provided to illustrate the concrete application of the method. - Abstract: Situation awareness (SA) is a key element that impacts operator’s decision-making and performance in nuclear power plants (NPPs). The subsequent complex cognitive activities cannot be correctly completed due to errors of situation awareness (ESA), which will lead to disastrous consequences. In order to investigate and analyze operator’s ESA in the digitized main control room (DMCR) of a nuclear power plant, the model of ESA is established, the classification system of ESA is developed based on the built ESA model, and the analysis method of ESA is also constructed on the basis of the observation of simulator and operator surveys. Finally, a case study is provided to illustrate the concrete application of the method. It provides a theoretical and practical support for the operator’s SAE analysis in a digitized main control room of a nuclear power plant.

  6. Laterally situated sinus pericranii

    International Nuclear Information System (INIS)

    Koshu, K.; Takahashi, S.

    1981-01-01

    Sinus pericranii has been reported to be situated usually along the midline. Two cases of laterally situated sinus pericranii are presented. Venous blood was obtained by puncturing the tumors directly. Injection of contrast medium into the tumors demonstrated a communication between the tumors and the intracranial venous sinuses through marked diploic veins. (orig.)

  7. Hadroproduction and photoproduction of beauty and charm in fixed-target experiments

    International Nuclear Information System (INIS)

    Slaughter, J.

    1996-01-01

    The authors summarize the current experimental situation for charm and beauty production in fixed-target experiments. Particular emphasis is placed on beauty cross-sections and charm pair correlations

  8. The Automotive Situation in Poznań versus other Cities and National Indexes

    Science.gov (United States)

    Kozak, Karolina; Kozak, Miłosław; Merkisz, Jerzy; Nijak, Dawid; Wiśniewska, Bożena

    2012-09-01

    Following the dynamic development of the automotive industry and economic changes in the last 20 years Polish transport-related needs and citizen mobility have changed as well. An increased demand for traveling and easy access to individual means of transport in the form of passenger cars put Poznan in the top ten of the largest cities of Poland in terms of the motorization level. The paper analyses the current situation of the level of motorization of the city of Poznan based on statistical data from Central Vehicle and Driver Register, Department of Motor Vehicles in Poznan and published by Central Office of Statistics. A synthetic analysis has been presented of the situation in Poznan against other largest cities of Poland and the average situation in the country. The paper also presents the analysis of the preferences of the citizens of Poznan in terms of engine capacity, type of fuel, engine type as and the most popular vehicle makes.

  9. Education as an income situation determinant of a consumer

    Directory of Open Access Journals (Sweden)

    Ladislav Stejskal

    2010-01-01

    Full Text Available The article is focused on an analysis of educational attainment of an individual and income ­situation of their household. At the beginning, a compendious summary of secondary sources is introduced. It resumes data supporting and contradicting the hypothesis about education as a determinant of an income situation. The preliminary theses analysis is performed by results quantification of a project called European Union – Statistics on Income and Living Conditions (EU-SILC. Aim of the paper is to verify the input thesis assumed from secondary resources. The thesis concerns the direct ­proportion between a level of education achieved and level of financial income. An introduction of a methodolo­gy and research summarized data forms a basis for particular analyses which are based on a conjunction of obtained information on household average monthly income and the educational attainment of their leading member. Analyses are sustained by contingency which characteri­zes social groups, i.e. spheres in which leading members are mostly involved with regard to income.Research results proved the validity of the preliminary thesis about correlation, respectively direct proportionality of educational attainment and monthly income amount. Education is consequently identified as one of income situation determinants. The authors anticipate specificity of the selected point of view. Results are therefore presented only as a partial argument and a possible base for further enquiries.

  10. Do stages of dentistry training affect anxiety provoking situations ...

    African Journals Online (AJOL)

    Getting diagnosis wrong, help in faint episode, not developing radiograph properly and coping with children were the anxiety provoking situations that showed statistically significant difference in the 3 studied training stages of dentistry. Bonferroni post‑hoc analysis significant difference was in the preclinical and clinical ...

  11. RADCHEM 2005 - Radiochemical analysis in emergency and routine situations

    International Nuclear Information System (INIS)

    Sidhu, R.

    2006-04-01

    The report describes the work performed under the NKS-B project Radchem during 2005. RadChem-2005 has been focused towards laboratory work, and each participant has worked with improvement of existing procedures or development of new procedures. In addition an intercomparison exercise on the determination of natural radionuclides in ground water has been performed. Other work performed in Radchem-2005 include: 1) Development of new procedures for the determination of Am and Cm in environmental samples; 2) Development of a procedure for age determination of Pu; 3) Rapid determination of Pu using ICP-MS; 4) Determination of U, Pu and Am in emergency situations; 5) Sequential determination of Sr, U, Pu, Am and Cm in urine; 6) Ultra low level measurements using ICP-MS. (au)

  12. Representing Operational Modes for Situation Awareness

    International Nuclear Information System (INIS)

    Kirchhübel, Denis; Lind, Morten; Ravn, Ole

    2017-01-01

    Operating complex plants is an increasingly demanding task for human operators. Diagnosis of and reaction to on-line events requires the interpretation of real time data. Vast amounts of sensor data as well as operational knowledge about the state and design of the plant are necessary to deduct reasonable reactions to abnormal situations. Intelligent computational support tools can make the operator’s task easier, but they require knowledge about the overall system in form of some model. While tools used for fault-tolerant control design based on physical principles and relations are valuable tools for designing robust systems, the models become too complex when considering the interactions on a plant-wide level. The alarm systems meant to support human operators in the diagnosis of the plant-wide situation on the other hand fail regularly in situations where these interactions of systems lead to many related alarms overloading the operator with alarm floods. Functional modelling can provide a middle way to reduce the complexity of plant-wide models by abstracting from physical details to more general functions and behaviours. Based on functional models the propagation of failures through the interconnected systems can be inferred and alarm floods can potentially be reduced to their root-cause. However, the desired behaviour of a complex system changes due to operating procedures that require more than one physical and functional configuration. In this paper a consistent representation of possible configurations is deduced from the analysis of an exemplary start-up procedure by functional models. The proposed interpretation of the modelling concepts simplifies the functional modelling of distinct modes. The analysis further reveals relevant links between the quantitative sensor data and the qualitative perspective of the diagnostics tool based on functional models. This will form the basis for the ongoing development of a novel real-time diagnostics system based

  13. Representing Operational Modes for Situation Awareness

    Science.gov (United States)

    Kirchhübel, Denis; Lind, Morten; Ravn, Ole

    2017-01-01

    Operating complex plants is an increasingly demanding task for human operators. Diagnosis of and reaction to on-line events requires the interpretation of real time data. Vast amounts of sensor data as well as operational knowledge about the state and design of the plant are necessary to deduct reasonable reactions to abnormal situations. Intelligent computational support tools can make the operator’s task easier, but they require knowledge about the overall system in form of some model. While tools used for fault-tolerant control design based on physical principles and relations are valuable tools for designing robust systems, the models become too complex when considering the interactions on a plant-wide level. The alarm systems meant to support human operators in the diagnosis of the plant-wide situation on the other hand fail regularly in situations where these interactions of systems lead to many related alarms overloading the operator with alarm floods. Functional modelling can provide a middle way to reduce the complexity of plant-wide models by abstracting from physical details to more general functions and behaviours. Based on functional models the propagation of failures through the interconnected systems can be inferred and alarm floods can potentially be reduced to their root-cause. However, the desired behaviour of a complex system changes due to operating procedures that require more than one physical and functional configuration. In this paper a consistent representation of possible configurations is deduced from the analysis of an exemplary start-up procedure by functional models. The proposed interpretation of the modelling concepts simplifies the functional modelling of distinct modes. The analysis further reveals relevant links between the quantitative sensor data and the qualitative perspective of the diagnostics tool based on functional models. This will form the basis for the ongoing development of a novel real-time diagnostics system based

  14. All in a day's work – variability in person-situation interactions in daily life situations

    DEFF Research Database (Denmark)

    Jensen, Lasse Meinert

    effect of persons’ situational concerns and intentions upon fluctuations in quality of experience. This paper will argue that the combination of findings (a) and (b) goes against the interpretation that persons merely “react” to situational features, and instead points to how subjective and agentic...... features of the person shape experience by way of guiding the person’s interaction with the situations of everyday life....

  15. USING THE METHOD OF SITUATIONAL ANALYSIS IN PROJECT MANAGEMENT TAKING INTO ACCOUNT SEASONALITY OF PRODUCTION

    Directory of Open Access Journals (Sweden)

    Тетяна Олександрівна ПРОКОПЕНКО

    2016-02-01

    Full Text Available There have been proposed methods of fuzzy situational approach, providing decision-making in project management in enterprises with seasonal nature of production. The model of fuzzy graph situational project management in the investment phase, providing adequate and effective opportunity to describe the project taking into account seasonality and uncertainty in the tasks of planning and decision making. The conclusions about the choice of alternative strategic solutions for companies considering the seasonality of production based on the proposed fuzzy graph situational solutions that allow for the special factors such as the nature of the project and the environment; uncertainty in the design and environment; take account of the conditions of the process; and evaluate the results of actions and make choices alternatives for achieving the strategic objectives of the various activities of the enterprise, taking into account the seasonal factor.

  16. Systematic review of effectiveness of situated e-learning on medical and nursing education.

    Science.gov (United States)

    Feng, Jui-Ying; Chang, Yi-Ting; Chang, Hsin-Yi; Erdley, William Scott; Lin, Chyi-Her; Chang, Ying-Ju

    2013-08-01

    Because of the complexity of clinical situations, traditional didactic education is limited in providing opportunity for student-patient interaction. Situated e-learning can enhance learners' knowledge and associated abilities through a variety of activities. Healthcare providers who interact with virtual patients in designed situations may avoid unnecessary risks and encounters with real patients. However, the effectiveness of situated e-learning is inconsistent. The purpose of this study is to determine the effectiveness of situated e-learning in prelicensure and postlicensure medical and nursing education. Literature databases of PubMed, Medline, CINAHL, ERIC, and Cochrane Library were searched. The study eligibility criteria included articles published in English, which examined the effectiveness of situated e-learning on the outcomes of knowledge and performance for clinicians or students in medicine and nursing. Effect sizes were calculated with 95% confidence intervals. Fourteen articles were included for meta-analysis. Situated e-learning could effectively enhance learners' knowledge and performance when the control group received no training. Compared to traditional learning, the effectiveness of situated e-learning on performance diminished but still remained significant whereas the effect become insignificant on knowledge. The subgroup analyses indicate the situated e-learning program significantly improved students' clinical performance but not for clinicians. Situated e-learning is an effective method to improve novice learners' performance. The effect of situated e-learning on the improvement of cognitive ability is limited when compared to traditional learning. Situated e-learning is a useful adjunct to traditional learning for medical and nursing students. © 2013 Sigma Theta Tau International.

  17. An analysis of current and desirable situation of electronic government service provision in rural areas of the Hamedan province

    Directory of Open Access Journals (Sweden)

    Mousa Aazami

    2017-04-01

    Full Text Available The informative society is seen as the central element of rural development at the beginning of the third millennium and the development of information technology and communication in villages has always been considered in current summits across the world. Nowadays, information and communication technology service offices are the basis of electronic government. Therefore, recognition of these offices is necessary for sustainable rural development. The purpose of this research was a comparative analysis between the current situation and the desirable situation of e-government services in the rural districts of the Hamedan province as perceived by their directors (Hamedan, Bahar and Famenin Counties. The study population consists of 91 respondents who were chosen and studied through the census method. The findings of this research study consist of two sections. The items related to satisfaction with the activities in information and communication technology service offices were prioritized in the first section. Moreover, the current and the desirable conditions for electronic service provision were identified. The gap between these two were analyzed in the second section. The results indicate that there is a significant difference between these two conditions of electronic service provisions in rural areas. This significant difference was recognized through the paired T test at the 0.05 level with 6.33 value that illustrates the existence of a gap between these two situations. Electronic government, information technology and communication, information and communication technology service offices

  18. Augmented Reality Tool for the Situational Awareness Improvement of UAV Operators

    Science.gov (United States)

    Ruano, Susana; Cuevas, Carlos; Gallego, Guillermo; García, Narciso

    2017-01-01

    Unmanned Aerial Vehicles (UAVs) are being extensively used nowadays. Therefore, pilots of traditional aerial platforms should adapt their skills to operate them from a Ground Control Station (GCS). Common GCSs provide information in separate screens: one presents the video stream while the other displays information about the mission plan and information coming from other sensors. To avoid the burden of fusing information displayed in the two screens, an Augmented Reality (AR) tool is proposed in this paper. The AR system has two functionalities for Medium-Altitude Long-Endurance (MALE) UAVs: route orientation and target identification. Route orientation allows the operator to identify the upcoming waypoints and the path that the UAV is going to follow. Target identification allows a fast target localization, even in the presence of occlusions. The AR tool is implemented following the North Atlantic Treaty Organization (NATO) standards so that it can be used in different GCSs. The experiments show how the AR tool improves significantly the situational awareness of the UAV operators. PMID:28178189

  19. Analysis of shots on target and goals scored in soccer matches ...

    African Journals Online (AJOL)

    The aim of this study was to analyse the characteristics and patterns of shots on target and goals scored during the 2012-European Championship. The broadcasted matches were recorded and converted into electronic video files for a computerbased analysis. This quantitative study examined 31 matches of the ...

  20. An analysis of health promotion materials for Dutch truck drivers: Off target and too complex?

    Science.gov (United States)

    Boeijinga, Anniek; Hoeken, Hans; Sanders, José

    2017-01-01

    Despite various health promotion initiatives, unfavorable figures regarding Dutch truck drivers' eating behaviors, exercise behaviors, and absenteeism have not improved. The aim was to obtain a better understanding of the low level of effectiveness of current health interventions for Dutch truck drivers by examining to what extent these are tailored to the target group's particular mindset (focus of content) and health literacy skills (presentation of content). The article analyzes 21 health promotion materials for Dutch truck drivers using a two-step approach: (a) an analysis of the materials' focus, guided by the Health Action Process Approach; and (b) an argumentation analysis, guided by pragma-dialectics. The corpus analysis revealed: (a) a predominant focus on the motivation phase; and (b) in line with the aim of motivating the target group, a consistent use of pragmatic arguments, which were typically presented in an implicit way. The results indicate that existing health promotion materials for Dutch truck drivers are not sufficiently tailored to the target group's mindset and health literacy skills. Recommendations are offered to develop more tailored/effective health interventions targeting this high-risk, underserved occupational group.

  1. TRAC analysis of design basis events for the accelerator production of tritium target/blanket

    International Nuclear Information System (INIS)

    Lin, J.C.; Elson, J.

    1997-01-01

    A two-loop primary cooling system with a residual heat removal system was designed to mitigate the heat generated in the tungsten neutron source rods inside the rungs of the ladders and the shell of the rungs. The Transient Reactor Analysis Code (TRAC) was used to analyze the thermal-hydraulic behavior of the primary cooling system during a pump coastdown transient; a cold-leg, large-break loss-of-coolant accident (LBLOCA); a hot-leg LBLOCA; and a target downcomer LBLOCA. The TRAC analysis results showed that the heat generated in the tungsten neutron source rods can be mitigated by the primary cooling system for the pump coastdown transient and all the LBLOCAs except the target downcomer LBLOCA. For the target downcomer LBLOCA, a cavity flood system is required to fill the cavity with water at a level above the large fixed headers

  2. JOKE STRATEGIES IN AMERICAN SITUATIONAL COMEDY “HOW I MET YOUR MOTHER”

    Directory of Open Access Journals (Sweden)

    Awliya Rahmi

    2017-08-01

    Full Text Available The research discusse joke strategies in American situational comedy How I Met You Mother (HIMYM. The purpose of this research is to identify; (1 the joke strategies in situational comedy HIMYM (2 The pragmatic meaning of jokes that are expressed by the characters in HIMYM AND (3 Pragmatic prank functions that are expressed by the characters in HIMYM. This research is categorized as descriptive linguistic research. Observation method applied in data collection, while the method of distribution and matching applied in analyzing data. The results of this research data analysis is presented using informal and formal methods. From the results of data analysis found 14 strategy joke uttered by characters in a situational comedy American HIMYM, namely: ambiguity, grammar, syllabics, idiomatics, questionable English, antonymics, style, negativism, lexicography, spelling, punctuation, Rhyming English, numerical English And part of speech. The dominant strategy used is ambiguity because there are many words in English that mean more than one and are likely to lead the listener to multiple interpretations. The jokes uttered by the characters in situational comedy HIMYM have assertive, expressive and directive meanings. Moreover, the joke also serves to show the power, solidarity and psychological defense of the speaker.

  3. Constructivism, the so-called semantic learning theories, and situated cognition versus the psychological learning theories.

    Science.gov (United States)

    Aparicio, Juan José; Rodríguez Moneo, María

    2005-11-01

    In this paper, the perspective of situated cognition, which gave rise both to the pragmatic theories and the so-called semantic theories of learning and has probably become the most representative standpoint of constructivism, is examined. We consider the claim of situated cognition to provide alternative explanations of the learning phenomenon to those of psychology and, especially, to those of the symbolic perspective, currently predominant in cognitive psychology. The level of analysis of situated cognition (i.e., global interactive systems) is considered an inappropriate approach to the problem of learning. From our analysis, it is concluded that the pragmatic theories and the so-called semantic theories of learning which originated in situated cognition can hardly be considered alternatives to the psychological learning theories, and they are unlikely to add anything of interest to the learning theory or to contribute to the improvement of our knowledge about the learning phenomenon.

  4. School programs targeting stress management in children and adolescence: a meta-analysis

    NARCIS (Netherlands)

    Kraag, G.C; Zeegers, M.P.; Kok, G.J.; Hosman, C.M.H.; Huijer Abu-Saad, H.

    2006-01-01

    Introduction This meta-analysis evaluates the effect of school programs targeting stress management or coping skills in school children. Methods Articles were selected through a systematic literature search. Only randomized controlled trials or quasi-experimental studies were included. The

  5. Inference of miRNA targets using evolutionary conservation and pathway analysis

    Directory of Open Access Journals (Sweden)

    van Nimwegen Erik

    2007-03-01

    assigns a posterior probability to each putative target site. The results presented here indicate that our general method achieves very good performance in predicting miRNA target sites, providing at the same time insights into the evolution of target sites for individual miRNAs. Moreover, by combining our predictions with pathway analysis, we propose functions of specific miRNAs in nervous system development, inter-cellular communication and cell growth. The complete target site predictions as well as the miRNA/pathway associations are accessible on the ElMMo web server.

  6. Extended Target Recognition in Cognitive Radar Networks

    Directory of Open Access Journals (Sweden)

    Xiqin Wang

    2010-11-01

    Full Text Available We address the problem of adaptive waveform design for extended target recognition in cognitive radar networks. A closed-loop active target recognition radar system is extended to the case of a centralized cognitive radar network, in which a generalized likelihood ratio (GLR based sequential hypothesis testing (SHT framework is employed. Using Doppler velocities measured by multiple radars, the target aspect angle for each radar is calculated. The joint probability of each target hypothesis is then updated using observations from different radar line of sights (LOS. Based on these probabilities, a minimum correlation algorithm is proposed to adaptively design the transmit waveform for each radar in an amplitude fluctuation situation. Simulation results demonstrate performance improvements due to the cognitive radar network and adaptive waveform design. Our minimum correlation algorithm outperforms the eigen-waveform solution and other non-cognitive waveform design approaches.

  7. Quantification and Analysis of Offensive Situations in Different Formats of Sided Games In Soccer

    Directory of Open Access Journals (Sweden)

    Garcia Jorge Diaz-Cidoncha

    2014-12-01

    Full Text Available There has been a lot of research that enabled soccer to improve: its technique, tactics and strategy through analysis and training. Nevertheless, players’ need to interact with each other turns any defending or attacking situation into complex solutions with a wide range of variables to be considered, in which the player is never isolated and must make the move that has the most positive impact on play. Fifty-four sided games played in three different formats (5v5, 7v7 and 9v9 and with two age groups (U9 and U14 were filmed at three soccer clubs in Spain in order to identify the most relevant attacking moves, from a technical and tactical perspective. This study used the observational method; it is descriptive and is applied through well-prepared systematic quantitative observation in a natural environment. A key part of the method involved viewing the match recordings and logging moves that had been categorised beforehand. Cohen’s Kappa analysis showed that the results for the most representative variables presented a substantial degree of concordance (0.61-0.80. The results show that there were significant variations depending on the game format, and the following study will present a description and analysis of the aspects that had considerable influence on attacking moves in different formats of sided games (5v5, 7v7 and 9v9. The study also presents various practical applications for the area of training and analysing both youth and professional soccer.

  8. Situating Engagement

    DEFF Research Database (Denmark)

    Korn, Matthias

    Our mobile phone is with us at all times. Habitually, we pick it up in the morning and carry it around on our daily routes and routines. Increasingly, we use it to locate ourselves and the things and people around us. With ubiquitous computing, technology is moving into the very fabric of our....... First, situationally appropriate forms of engagement that align well with citizens’ own conceptions are necessary in order to provide relevance and meaning of issues in the moment. Second, situated engagement requires a technological setup which facilitates the co-location of people, place...... with sophisticated prototypes in the wild. It proposes walkshops as a technique for collaborative exploration within actual outdoor environments and the use of field trials as part of an iterative design process in order to look ahead toward use practices that are still in the making....

  9. FMEA and consideration of real work situations for safer design of production systems.

    Science.gov (United States)

    Lux, Aurélien; Mawo De Bikond, Johann; Etienne, Alain; Quillerou-Grivot, Edwige

    2016-12-01

    Production equipment designers must ensure the health and safety of future users; in this regard, they augment requirements for standardizing and controlling operator work. This contrasts with the ergonomic view of the activity, which recommends leaving operators leeway (margins for manoeuvre) in performing their task, while safeguarding their health. Following a brief analysis of design practices in the car industry, we detail how the Failure Modes and Effects Analysis (FMEA) approach is implemented in this sector. We then suggest an adaptation that enables designers to consider real work situations. This new protocol, namely, work situation FMEA, allows experience feedback to be used to defend the health standpoint during designer project reviews, which usually only address quality and performance issues. We subsequently illustrate the advantage of this approach using two examples of work situations at car parts manufacturers: the first from the literature and the second from an in-company industrial project.

  10. Screening situations for risk of ethical conflicts: a pilot study.

    Science.gov (United States)

    Pavlish, Carol L; Hellyer, Joan Henriksen; Brown-Saltzman, Katherine; Miers, Anne G; Squire, Karina

    2015-05-01

    Ethical conflicts, often leading to poor teamwork and moral distress, are very challenging to patients, patients' families, and health care providers. A proactive approach to ethical conflicts may improve patient care outcomes. To examine acceptability and feasibility of an ethics screening and early intervention tool for use by nurses caring for critically ill patients. Twenty-eight nurses in 2 medical centers applied the ethics screening tool to 55 patient situations. Nurses assessed situations for risk factors and early indicators of ethical conflicts and analyzed level of risk. At study completion, nurses participated in focus group discussions about the tool's benefits and challenges. Frequency counts were performed on risk factors and early indicators of ethical conflicts. Content analysis was used on written explanations regarding high-, medium-, and low-risk situations and on focus group data. Older patients with multiple comorbid conditions and aggressive treatments were frequently assessed to be at risk for ethical conflicts. Nurses who witnessed patients' suffering and deterioration were likely to initiate the screening process. The most prominent family risk factors included unrealistic expectations and adamancy about treatment. The most prominent early indicators were signs of patients' suffering, unrealistic expectations, and providers' own moral distress. High-risk situations averaged a greater number of risk factors and early indicators than did medium- and low-risk situations. Certain risk factors featured prominently in high-risk situations. A phenomenon of shared suffering emerged from the study and signifies the importance of relational strategies such as routine family conferences and ethics consultation. ©2015 American Association of Critical-Care Nurses.

  11. Managing and engineering in complex situations

    CERN Document Server

    Sousa-Poza, Andres

    2013-01-01

    With so many terms available to define the same thing, it would seem nearly irresponsible to introduce yet another term (complex situation) to describe a phenomenological state of such as a system. However, a complex situation infers both a broader meaning and imposes a different perspective. Complex in this context is dependent on understanding and reality rather than observer and knowledge.   Situation imposes a gestalt that cannot be characterized within a singular perspective that relegates paradox to a superior/subordinate hierarchy. This also infers that complex situation has no monotonic definition or each definition is by default incomplete. Therefore the perennial derivations for systems such as complex systems, system of systems, federation of systems is no longer a sufficient descriptor for complex situation.  Ergo system and its genealogy lack the constitution to define complex situations. The books' intent is to explore this pathology through a series of papers written by authors that work in ...

  12. Dual mobility cups provide biomechanical advantages in situations at risk for dislocation: a finite element analysis.

    Science.gov (United States)

    Terrier, Alexandre; Latypova, Adeliya; Guillemin, Maika; Parvex, Valérie; Guyen, Olivier

    2017-03-01

    Constrained devices, standard implants with large heads, and dual mobility systems have become popular options to manage instability after total hip arthroplasty (THA). Clinical results with these options have shown variable success rates and significant higher rates of aseptic loosening and mechanical failures with constrained implants. Literature suggests potential advantages of dual mobility, however little is known about its biomechanics. We present a comparative biomechanical study of a standard implant, a constrained implant, and a dual mobility system. A finite element analysis was developed to assess and compare these acetabular options with regard to the range of motion (ROM) to impingement, the angle of dislocation, the resistive torque, the volume of polyethylene (PE) with a stress above 80% of the elastic limit, and the interfacial cup/bone stress. Dual mobility implants provided the greatest ROM to impingement and allowed delaying subluxation and dislocation when compared to standard and constrained implants. Dual mobility also demonstrated the lowest resistive torque at subluxation while the constrained implant provided the greatest one. The lowest critical PE volume was observed with the dual mobility implant, and the highest stress at the interfaces was observed with the constrained implant. This study highlights the biomechanical advantages of dual mobility systems over constrained and standard implants, and is supported by the clinical results reported. Therefore, the use of dual mobility systems in situations at risk for instability should be advocated and constrained implants should be restricted to salvage situations.

  13. Argumentation functions in solving conflicting situations of social interaction in students of different age

    Directory of Open Access Journals (Sweden)

    T.V. Morozova

    2013-10-01

    Full Text Available The paper describes the results of a study of functions of argumentation in solving conflicting situations of social interaction, with the participation of younger students (III and IV grade, middle school students (V and VII grade and high school students (X classes, 211 students overall. The starting point of the research was the idea that distress occurring in a contradictory situation, does not relieve externally, but requires a structural analysis of the situation and a decision from the subject. The hypothesis of the study was the assumption that the argument used by the subject in a situation, can have opposite functions: a real change in the situation or a formal removal of contradictions in order to reduce stress. The author notes that overcoming the contradictions is linked inevitably to the need to clarify the rules of interaction between the parties, and this in turn puts the subject under certain psychological risk (the risk of criticism, disapproval or punishment, the risk of loss of secondary benefits of ambiguous situation, etc. that impede productive action in a contradictory situation.

  14. Interviews with children of persons with a severe mental illness: investigating their everyday situation.

    Science.gov (United States)

    Ostman, Margareta

    2008-01-01

    Research on children of persons with a severe mental illness focuses predominantly on parents' and others' perceptions. Children of mentally ill parents form a vulnerable group that has not been adequately paid attention to in psychiatric care institutions. Comparatively little is known about the children's recognition of their parents and the everyday situation of these families. The aim of the study was to investigate experiences of their life situation in children 10-18 years of age in a family with a parent with a severe mental illness. Eight children were interviewed concerning their everyday life situation. The interviews were analysed inspired from using thematic analysis. From the analysis of the material emerged aspects concerning the following themes: need for conversation, love for their family, maturity, experience of fear and blame, feelings of loneliness, responsibility and associated stigma. This study highlights the situation experienced by children of severely mentally ill persons who also are parents. The study may be found to be a basis for inspiring structured interventions and treatments programmes including children of the adult patients seeking psychiatric treatment.

  15. CANONICAL RELATIONS BETWEEN BASIC AND MOTOR - SITUATIONAL-MOTOR SKILLS IN SPORT GAMES

    Directory of Open Access Journals (Sweden)

    Bećir Šabotić

    2013-07-01

    Full Text Available The aim of this study was to establish the correlation between the predictor-basic motor and situational-motor tests in sports games. On the sample of 62 subjects of the first year of high school was carried out measurements which covered 12 basic and 6 motor variables and situational tests in volleyball and basketball.Based on the results of the canonical correlation analysis, it can be concluded that there is a significant relationship between the predictor variables and a set of criterion variables, situational-motor tests basketball and volleyball. These results are logical given the structure of movements from basketball and volleyball that require a high level of coordination and speed.

  16. Comparison of the calcium release channel of cardiac and skeletal muscle sarcoplasmic reticulum by target inactivation analysis

    International Nuclear Information System (INIS)

    McGrew, S.G.; Inui, Makoto; Chadwick, C.C.; Boucek, R.J. Jr.; Jung, C.Y.; Fleischer, S.

    1989-01-01

    The calcium release channel of sarcoplasmic reticulum which triggers muscle contraction in excitation-contraction coupling has recently been isolated. The channel has been found to be morphologically identical with the feet structures of the junctional face membrane of terminal cisternae and consists of an oligomer of a unique high molecular weight polypeptide. In this study, the authors compare the target size of the calcium release channel from heart and skeletal muscle using target inactivation analysis. The target molecular weights of the calcium release channel estimated by measuring ryanodine binding after irradiation are similar for heart (139,000) and skeletal muscle (143,000) and are smaller than the monomeric unit (estimated to be about 360,000). The target size, estimated by measuring polypeptide remaining after irradiation, was essentially the same for heart and skeletal muscle, 1,061,000 and 1,070,000, respectively, indicating an oligomeric association of protomers. Thus, the calcium release channel of both cardiac and skeletal muscle reacts uniquely with regard to target inactivation analysis in that (1) the size by ryanodine binding is smaller than the monomeric unit and (2) a single hit leads to destruction of more than one polypeptide, by measuring polypeptide remaining. The target inactivation analysis studies indicate that heart and skeletal muscle receptors are structurally very similar

  17. Dynamic thermal analysis of machines in running state

    CERN Document Server

    Wang, Lihui

    2014-01-01

    With the increasing complexity and dynamism in today’s machine design and development, more precise, robust and practical approaches and systems are needed to support machine design. Existing design methods treat the targeted machine as stationery. Analysis and simulation are mostly performed at the component level. Although there are some computer-aided engineering tools capable of motion analysis and vibration simulation etc., the machine itself is in the dry-run state. For effective machine design, understanding its thermal behaviours is crucial in achieving the desired performance in real situation. Dynamic Thermal Analysis of Machines in Running State presents a set of innovative solutions to dynamic thermal analysis of machines when they are put under actual working conditions. The objective is to better understand the thermal behaviours of a machine in real situation while at the design stage. The book has two major sections, with the first section presenting a broad-based review of the key areas of ...

  18. Mechanism of microRNA-target interaction: molecular dynamics simulations and thermodynamics analysis.

    Directory of Open Access Journals (Sweden)

    Yonghua Wang

    Full Text Available MicroRNAs (miRNAs are endogenously produced approximately 21-nt riboregulators that associate with Argonaute (Ago proteins to direct mRNA cleavage or repress the translation of complementary RNAs. Capturing the molecular mechanisms of miRNA interacting with its target will not only reinforce the understanding of underlying RNA interference but also fuel the design of more effective small-interfering RNA strands. To address this, in the present work the RNA-bound (Ago-miRNA, Ago-miRNA-target and RNA-free Ago forms were analyzed by performing both molecular dynamics simulations and thermodynamic analysis. Based on the principal component analysis results of the simulation trajectories as well as the correlation analysis in fluctuations of residues, we discover that: 1 three important (PAZ, Mid and PIWI domains exist in Argonaute which define the global dynamics of the protein; 2 the interdomain correlated movements are so crucial for the interaction of Ago-RNAs that they not only facilitate the relaxation of the interactions between residues surrounding the RNA binding channel but also induce certain conformational changes; and 3 it is just these conformational changes that expand the cavity of the active site and open putative pathways for both the substrate uptake and product release. In addition, by thermodynamic analysis we also discover that for both the guide RNA 5'-end recognition and the facilitated site-specific cleavage of the target, the presence of two metal ions (of Mg(2+ plays a predominant role, and this conclusion is consistent with the observed enzyme catalytic cleavage activity in the ternary complex (Ago-miRNA-mRNA. Our results find that it is the set of arginine amino acids concentrated in the nucleotide-binding channel in Ago, instead of the conventionally-deemed seed base-paring, that makes greater contributions in stabilizing the binding of the nucleic acids to Ago.

  19. Mechanism of microRNA-target interaction: molecular dynamics simulations and thermodynamics analysis.

    Science.gov (United States)

    Wang, Yonghua; Li, Yan; Ma, Zhi; Yang, Wei; Ai, Chunzhi

    2010-07-29

    MicroRNAs (miRNAs) are endogenously produced approximately 21-nt riboregulators that associate with Argonaute (Ago) proteins to direct mRNA cleavage or repress the translation of complementary RNAs. Capturing the molecular mechanisms of miRNA interacting with its target will not only reinforce the understanding of underlying RNA interference but also fuel the design of more effective small-interfering RNA strands. To address this, in the present work the RNA-bound (Ago-miRNA, Ago-miRNA-target) and RNA-free Ago forms were analyzed by performing both molecular dynamics simulations and thermodynamic analysis. Based on the principal component analysis results of the simulation trajectories as well as the correlation analysis in fluctuations of residues, we discover that: 1) three important (PAZ, Mid and PIWI) domains exist in Argonaute which define the global dynamics of the protein; 2) the interdomain correlated movements are so crucial for the interaction of Ago-RNAs that they not only facilitate the relaxation of the interactions between residues surrounding the RNA binding channel but also induce certain conformational changes; and 3) it is just these conformational changes that expand the cavity of the active site and open putative pathways for both the substrate uptake and product release. In addition, by thermodynamic analysis we also discover that for both the guide RNA 5'-end recognition and the facilitated site-specific cleavage of the target, the presence of two metal ions (of Mg(2+)) plays a predominant role, and this conclusion is consistent with the observed enzyme catalytic cleavage activity in the ternary complex (Ago-miRNA-mRNA). Our results find that it is the set of arginine amino acids concentrated in the nucleotide-binding channel in Ago, instead of the conventionally-deemed seed base-paring, that makes greater contributions in stabilizing the binding of the nucleic acids to Ago.

  20. Indication of the incineration situation using image analysis of the grate boilers fireplace; Indikation av foerbraenningssituationen genom bildanalys av rostens eldstad

    Energy Technology Data Exchange (ETDEWEB)

    Persson, Anna; Helgesson, Johan [Vattenfall Utveckling AB, Aelvkarleby (Sweden)

    2004-12-01

    Vattenfall Utveckling AB has earlier performed tests where the incineration situation in a black liquor recovery boiler (BLRB) has been investigated using a simple water-cooled camera. It was also shown possible to repress emission lines for e.g., sodium. These results led to wishes of performing the same tests in a grate boiler. Initially in the project, an investigation about what effect optical filters has on the image from a camera that captures the incineration situation in a grate boiler. The goal was to improve the conditions for flame front detection using image analysis, i.e., to increase the contrast between flames (the flame front) and no flames (bed, ashes, walls etc.). The result was that the image improvement optical filters were predicted to give, did not happen. The conclusion of the investigation is therefore that the best result is achieved when no information-reducing filters are used in front of the camera. However, for cameras using automatic shutter, intensity-reducing filters are recommended. After that, an image analysis algorithm to automatically detect the location of the flame front on the bed was implemented. The evaluation of the algorithm was successfully performed on movies from three grate boilers. This method should be possible to implement for all types of grate boilers, regardless of size and fuel type. However, the material (e.g., wide angle objective) and the placement of the camera have to be individually adjusted. In a future project, the goal is to be able to reconnect this information about the instant incineration situation to the control system to control e.g., the air supply or the fuel feed. This could lead to lower emissions, higher efficiency and an operation less sensitive against changes in fuel quality.

  1. CANONIC RELATION BASICO-MOTORICAL ABILITIES ON SITUATION SUCCESSFUL CHILDREN IN SMALL FOOTBALL

    Directory of Open Access Journals (Sweden)

    Izudin Tanović

    2011-03-01

    Full Text Available Football appertain to group polystructual sports, which characterize very big number different not standardize motorical abilities and technics which footballplayers execute in variable situations, begin intention or accidently during the game( Elsner,B.1985..For the difference of the big football,small football or Futsall presents game which is condition with very considerable space and time-limitation which are manifestate with very fast transformation of game from the phase of attack to phase of defence.Dinamic of game, difference of not-standaardize abilities, and application situation individual technic for successful deduction of actions request from player and very big level of psychocondition readiness. The aim of this exploration was to realize the level of influence basico-motorical abilities on situation successful in small football (Futsall game. Exploration is done on the children from the 12-14 years,at the school of small football in SFC “OT of MOSTAR”(OLD TOWN OF MOSTAR from the Mostar. Take into consideration strature characteristics and magnitude choosen pattern of children, and the target of exploration,processing the results are done with metod canonic-coleration analise. Final results of this exploration are characteristic for exploring strature,but also the same confirmation that exist statisticly very important binded between exploration spaces

  2. Heavy-Quark Production in the Target Fragmentation Region

    CERN Document Server

    Graudenz, Dirk

    1997-01-01

    Fixed-target experiments permit the study of hadron production in the target fragmentation region. It is expected that the tagging of specific particles in the target fragments can be employed to introduce a bias in the hard scattering process towards a specific flavour content. The case of hadrons containing a heavy quark is particularly attractive because of the clear experimental signatures and the applicability of perturbative QCD. The standard approach to one-particle inclusive processes based on fragmentation functions is valid in the current fragmentation region and for large transverse momenta $p_T$ in the target fragmentation region, but it fails for particle production at small $p_T$ in the target fragmentation region. A collinear singularity, which cannot be absorbed in the standard way into the phenomenological distribution functions, prohibits the application of this procedure. This situation is remedied by the introduction of a new set of distribution functions, the target fragmentation function...

  3. The Effect of Campaign-Generated Interpersonal Communication on Campaign-Targeted Health Outcomes: A Meta-Analysis.

    Science.gov (United States)

    Jeong, Michelle; Bae, Rosie Eungyuhl

    2017-06-16

    This study examined the effect of mass media campaign-generated conversations on campaign-targeted health outcomes, via a systematic meta-analysis of 28 studies (including 124 sub-studies and a total of 138,898 participants). The study also conducted a series of moderation analyses to examine the conditions under which interpersonal communication has larger effects on bringing about the desired outcomes. The findings of this meta-analysis indicate that campaign-generated conversations have a positive effect on inducing campaign-targeted outcomes (OR = 1.28) and show that this effect is moderated by health topic addressed by the campaign, the type of outcome being targeted by the campaign, and with whom people converse, along with several other campaign-relevant and study-relevant variables. The implications of these findings for future research are discussed.

  4. Learning situation models in a smart home.

    Science.gov (United States)

    Brdiczka, Oliver; Crowley, James L; Reignier, Patrick

    2009-02-01

    This paper addresses the problem of learning situation models for providing context-aware services. Context for modeling human behavior in a smart environment is represented by a situation model describing environment, users, and their activities. A framework for acquiring and evolving different layers of a situation model in a smart environment is proposed. Different learning methods are presented as part of this framework: role detection per entity, unsupervised extraction of situations from multimodal data, supervised learning of situation representations, and evolution of a predefined situation model with feedback. The situation model serves as frame and support for the different methods, permitting to stay in an intuitive declarative framework. The proposed methods have been integrated into a whole system for smart home environment. The implementation is detailed, and two evaluations are conducted in the smart home environment. The obtained results validate the proposed approach.

  5. Situating beyond the social

    DEFF Research Database (Denmark)

    Soffer, Ann Katrine Bønnelykke

    2016-01-01

    Situated learning serves as an analytical framework for learning in a community of practice and has been widely used to understand the learning process that is entailed in becoming a nurse. Yet in this paper, the difficulties encountered with the original notion of situated learning once...... framework. I suggest the notion of multi-configured learning, which captures the heterogeneity and materiality encountered during ethnographic fieldwork at a Danish nursing school....

  6. Modeling Air Traffic Situation Complexity with a Dynamic Weighted Network Approach

    Directory of Open Access Journals (Sweden)

    Hongyong Wang

    2018-01-01

    Full Text Available In order to address the flight delays and risks associated with the forecasted increase in air traffic, there is a need to increase the capacity of air traffic management systems. This should be based on objective measurements of traffic situation complexity. In current air traffic complexity research, no simple means is available to integrate airspace and traffic flow characteristics. In this paper, we propose a new approach for the measurement of air traffic situation complexity. This approach considers the effects of both airspace and traffic flow and objectively quantifies air traffic situation complexity. Considering the aircraft, waypoints, and airways as nodes, and the complexity relationships among these nodes as edges, a dynamic weighted network is constructed. Air traffic situation complexity is defined as the sum of the weights of all edges in the network, and the relationships of complexity with some commonly used indices are statistically analyzed. The results indicate that the new complexity index is more accurate than traffic count and reflects the number of trajectory changes as well as the high-risk situations. Additionally, analysis of potential applications reveals that this new index contributes to achieving complexity-based management, which represents an efficient method for increasing airspace system capacity.

  7. Proficiency Test in the Analysis of Gamma Spectra for Malevolent Radiological Situations (MALRAD)

    DEFF Research Database (Denmark)

    Dowdall, M.; Andersson, Kasper Grann; Sidhu, R. Singh

    individual laboratories responded. The majority of laboratories were in a position to satisfactorily identify sources where single sources were used in situations with no complicating factors. For those scenarios involving heavy shielding som difficulties were encountered due to distortion of the spectrum...

  8. Expression analysis of miRNA and target mRNAs in esophageal cancer

    Energy Technology Data Exchange (ETDEWEB)

    Meng, X.R. [Oncology Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou (China); Lu, P. [Gastrointestinal Surgery Department, People' s Hospital of Zhengzhou, Zhengzhou (China); Mei, J.Z.; Liu, G.J. [Medical Oncology Department, People' s Hospital of Zhengzhou, Zhengzhou (China); Fan, Q.X. [Oncology Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou (China)

    2014-08-01

    We aimed to investigate miRNAs and related mRNAs through a network-based approach in order to learn the crucial role that they play in the biological processes of esophageal cancer. Esophageal squamous-cell carcinoma (ESCC) and adenocarcinoma (EAC)-related miRNA and gene expression data were downloaded from the Gene Expression Omnibus database, and differentially expressed miRNAs and genes were selected. Target genes of differentially expressed miRNAs were predicted and their regulatory networks were constructed. Differentially expressed miRNA analysis selected four miRNAs associated with EAC and ESCC, among which hsa-miR-21 and hsa-miR-202 were shared by both diseases. hsa-miR-202 was reported for the first time to be associated with esophageal cancer in the present study. Differentially expressed miRNA target genes were mainly involved in cancer-related and signal-transduction pathways. Functional categories of these target genes were related to transcriptional regulation. The results may indicate potential target miRNAs and genes for future investigations of esophageal cancer.

  9. Electro-optic analysis of the influence of target geometry on electromagnetic pulses generated by petawatt laser-matter interactions

    Science.gov (United States)

    Robinson, Timothy; Giltrap, Samuel; Eardley, Samuel; Consoli, Fabrizio; De Angelis, Riccardo; Ingenito, Francesco; Stuart, Nicholas; Verona, Claudio; Smith, Roland A.

    2018-01-01

    We present an analysis of strong laser-driven electromagnetic pulses using novel electro-optic diagnostic techniques. A range of targets were considered, including thin plastic foils (20-550 nm) and mass-limited, optically-levitated micro-targets. Results from foils indicate a dependence of EMP on target thickness, with larger peak electric fields observed with thinner targets. Spectral analysis suggests high repeatability between shots, with identified spectral features consistently detected with earth following ejection of hot electrons from the plasma, in contrast to predictions for pin-mounted foils in the Poyé EMP generation model. With levitated targets, no EMP was measurable above the noise threshold of any diagnostic, despite observation of protons accelerated to >30 MeV energies, suggesting the discharge current contribution to EMP is dominant.

  10. One target, different effects: a comparison of distinct therapeutic antibodies against the same targets.

    Science.gov (United States)

    Shim, Hyunbo

    2011-10-31

    To date, more than 30 antibodies have been approved worldwide for therapeutic use. While the monoclonal antibody market is rapidly growing, the clinical use of therapeutic antibodies is mostly limited to treatment of cancers and immunological disorders. Moreover, antibodies against only five targets (TNF-α, HER2, CD20, EGFR, and VEGF) account for more than 80 percent of the worldwide market of therapeutic antibodies. The shortage of novel, clinically proven targets has resulted in the development of many distinct therapeutic antibodies against a small number of proven targets, based on the premise that different antibody molecules against the same target antigen have distinct biological and clinical effects from one another. For example, four antibodies against TNF-α have been approved by the FDA -- infliximab, adalimumab, golimumab, and certolizumab pegol -- with many more in clinical and preclinical development. The situation is similar for HER2, CD20, EGFR, and VEGF, each having one or more approved antibodies and many more under development. This review discusses the different binding characteristics, mechanisms of action, and biological and clinical activities of multiple monoclonal antibodies against TNF-α, HER-2, CD20, and EGFR and provides insights into the development of therapeutic antibodies.

  11. Planning as situated design

    DEFF Research Database (Denmark)

    Axel, Erik

    It is common to associate situated activity with concrete, craftlike or manual activity here and now and to reserve theoretical and abstract thinking for activities like theoretical experimentation and systematic planning. Much work has gone into demonstrating that these activities are concrete...... and situated, too. In this presentation it will be argued that the investigation of systematic planning as conflictual cooperation will help us see that situated activity is not only based on the present conditions, but also relates them to events spread out in time and space, thereby opening up for another...... understanding of theoretical thinking. Some material from the empirical research project developed with Klaus Nielsen on the design and engineering of a house will be presented. On this basis a conception of planning will be unfolded. It will be understood differently from the way it is understood...

  12. Evaluation of the use of pectin among children living on the territories contaminated by cesium. Situation and critical analysis of publications

    International Nuclear Information System (INIS)

    Jourdain, J.R.; Dublineau, I.; Phan, G.

    2005-01-01

    This report includes four parts. The first one gives the situation of knowledge on the biological effects of pectin in human nutrition and in case of exposure to heavy metals. The second part presents an analysis of publications devoted to biological effects of pectins in case of chronic intake of radioisotopes.The third part is a synthesis that gives the principal teaching of this analysis. The last part presents the propositions of I.R.S.N relative to future works and studies that it would be interesting to launch in order to complete the knowledge relative to the use of pectin in the case of chronic intake of radioisotopes. (N.C.)

  13. Human Factors for Situation Assessment in Grid Operations

    Energy Technology Data Exchange (ETDEWEB)

    Guttromson, Ross T.; Schur, Anne; Greitzer, Frank L.; Paget, Mia L.

    2007-08-08

    Executive Summary Despite advances in technology, power system operators must assimilate overwhelming amounts of data to keep the grid operating. Analyses of recent blackouts have clearly demonstrated the need to enhance the operator’s situation awareness (SA). The long-term objective of this research is to integrate valuable technologies into the grid operator environment that support decision making under normal and abnormal operating conditions and remove non-technical barriers to enable the optimum use of these technologies by individuals working alone and as a team. More specifically, the research aims to identify methods and principles to increase SA of grid operators in the context of system conditions that are representative or common across many operating entities and develop operationally relevant experimental methods for studying technologies and operational practices which contribute to SA. With increasing complexity and interconnectivity of the grid, the scope and complexity of situation awareness have grown. New paradigms are needed to guide research and tool development aimed to enhance and improve operations. In reviewing related research, operating practices, systems, and tools, the present study established a taxonomy that provides a perspective on research and development surrounding power grid situation awareness and clarifies the field of human factors/SA for grid operations. Information sources that we used to identify critical factors underlying SA included interviews with experienced operational personnel, available historical summaries and transcripts of abnormal conditions and outages (e.g., the August 14, 2003 blackout), scientific literature, and operational policies/procedures and other documentation. Our analysis of August 2003 blackout transcripts and interviews adopted a different perspective than previous analyses of this material, and we complemented this analysis with additional interviews. Based on our analysis and a broad

  14. Cultural conditioning: understanding interpersonal accommodation in India and the United States in terms of the modal characteristics of interpersonal influence situations.

    Science.gov (United States)

    Savani, Krishna; Morris, Michael W; Naidu, N V R; Kumar, Satishchandra; Berlia, Neha V

    2011-01-01

    We argue that differences between the landscapes of influence situations in Indian and American societies induce Indians to accommodate to others more often than Americans. To investigate cultural differences in situation-scapes, we sampled interpersonal influence situations occurring in India and the United States from both the influencee's (Study 1) and the influencer's (Study 2) perspectives. We found that Indian influence situations were dramatically more likely than U.S. situations to feature other-serving motives and to result in positive consequences for the relationship. Yet Study 3 found that targets of influence felt no less free to decide whether to accommodate in India than the United States, but felt more concerned about the influencer. To investigate the effects of situation-scapes on people's expectations and decisions, we exposed Indian and American participants to descriptions of situations from both societies (with their origins obscured). Study 4 found that both groups of participants expected more positive consequences from accommodation in Indian situations than in American situations. Finally, Study 5 found that both groups decided to accommodate more often in Indian situations than in American situations. At the same time, Indian participants were more likely than Americans to accommodate across all situations, but both groups converged over 100 trials as they were exposed to more and more situations drawn from each other's cultures. We interpret these effects in terms of the default decisions or biases conditioned by people's recently encountered situations. (PsycINFO Database Record (c) 2010 APA, all rights reserved).

  15. How to lead complex situations

    DEFF Research Database (Denmark)

    Hansen, Michael Pingel

    2013-01-01

    The military leader is experiencing increasingly more complex situations, whether it is as leader in a foreign combat environment or in the home-based public administration. Complex situations like these call for a special set of managerial responses and a special way of leading organisations...

  16. Ideal MHD stability analysis of KSTAR target AT mode

    International Nuclear Information System (INIS)

    Yi, S.M.; Kim, J.H.; You, K.I.; Kim, J.Y.

    2009-01-01

    Full text: A main research objective of KSTAR (Korea Superconducting Tokamak Advanced Research) device is to demonstrate the steady-state operation capability of high-performance AT (Advanced Tokamak) mode. To meet this goal, it is critical for KSTAR to have a good MHD stability boundary, particularly against the high-beta ideal instabilities such as the external kink and the ballooning modes. To support this MHD stability KSTAR has been designed to have a strong plasma shape and a close interval between plasma and passive- plate wall. During the conceptual design phase of KSTAR, a preliminary study was performed to estimate the high beta MHD stability limit of KSTAR target AT mode using PEST and VACUUM codes and it was shown that the target AT mode can be stable up to β N ∼ 5 with a well-defined plasma pressure and current profiles. Recently, a new calculation has been performed to estimate the ideal stability limit in various KSTAR operating conditions using DCON code, and it has been observed that there is some difference between the new and old calculation results, particularly in the dependence of the maximum β N value on the toroidal mode number. Here, we thus present a more detailed analysis of the ideal MHD stability limit of KSTAR target AT mode using various codes, which include GATO as well as PEST and DCON, in the comparison of calculation results among the three codes. (author)

  17. Allocating the Fixed Resources and Setting Targets in Integer Data Envelopment Analysis

    Directory of Open Access Journals (Sweden)

    Kobra Gholami

    2013-11-01

    Full Text Available Data envelopment analysis (DEA is a non-parametric approach to evaluate a set of decision making units (DMUs consuming multiple inputs to produce multiple outputs. Formally, DEA use to estimate the efficiency score into the empirical efficient frontier. Also, DEA can be used to allocate resources and set targets for future forecast. The data are continuous in the standard DEA model whereas there are many problems in the real life that data must be integer such as number of employee, machinery, expert and so on. Thus in this paper we propose an approach to allocate fixed resources and set fixed targets with selective integer assumption that is based on an integer data envelopment analysis (IDEA approach for the first time. The major aim in this approach is preserving the efficiency score of DMUs. We use the concept of benchmarking to reach this aim. The numerical example gets to illustrate the applicability of the proposed method.

  18. Analysis of Pilot Feedback Regarding the Use of State Awareness Technologies During Complex Situations

    Science.gov (United States)

    Evans, Emory; Young, Steven D.; Daniels, Taumi; Santiago-Espada, Yamira; Etherington, Tim

    2016-01-01

    A flight simulation study was conducted at NASA Langley Research Center to evaluate flight deck systems that (1) predict aircraft energy state and/or autoflight configuration, (2) present the current state and expected future state of automated systems, and/or (3) show the state of flight-critical data systems in use by automated systems and primary flight instruments. Four new technology concepts were evaluated vis-à-vis current state-of-the-art flight deck systems and indicators. This human-in-the-loop study was conducted using commercial airline crews. Scenarios spanned a range of complex conditions and several emulated causal factors and complexity in recent accidents involving loss of state awareness by pilots (e.g. energy state, automation state, and/or system state). Data were collected via questionnaires administered after each flight, audio/video recordings, physiological data, head and eye tracking data, pilot control inputs, and researcher observations. This paper strictly focuses on findings derived from the questionnaire responses. It includes analysis of pilot subjective measures of complexity, decision making, workload, situation awareness, usability, and acceptability.

  19. Immune checkpoint inhibitors and targeted therapies for metastatic melanoma: A network meta-analysis.

    Science.gov (United States)

    Pasquali, Sandro; Chiarion-Sileni, Vanna; Rossi, Carlo Riccardo; Mocellin, Simone

    2017-03-01

    Immune checkpoint inhibitors and targeted therapies, two new class of drugs for treatment of metastatic melanoma, have not been compared in randomized controlled trials (RCT). We quantitatively summarized the evidence and compared immune and targeted therapies in terms of both efficacy and toxicity. A comprehensive search for RCTs of immune checkpoint inhibitors and targeted therapies was conducted to August 2016. Using a network meta-analysis approach, treatments were compared with each other and ranked based on their effectiveness (as measured by the impact on progression-free survival [PFS]) and acceptability (the inverse of high grade toxicity). Twelve RCTs enrolling 6207 patients were included. Network meta-analysis generated 15 comparisons. Combined BRAF and MEK inhibitors were associated with longer PFS as compared to anti-CTLA4 (HR: 0.22; 95% confidence interval [CI]: 0.12-0.41) and anti-PD1 antibodies alone (HR: 0.38; CI: 0.20-0.72). However, anti-PD1 monoclonal antibodies were less toxic than anti-CTLA4 monoclonal antibodies (RR: 0.65; CI: 0.40-0.78) and their combination significantly increased toxicity compared to either single agent anti-CTLA4 (RR: 2.06; CI: 1.45-2.93) or anti-PD1 monoclonal antibodies (RR: 3.67; CI: 2.27-5.96). Consistently, ranking analysis suggested that the combination of targeted therapies is the most effective strategy, whereas single agent anti-PD1 antibodies have the best acceptability. The GRADE level of evidence quality for these findings was moderate to low. The simultaneous inhibition of BRAF and MEK appears the most effective treatment for melanomas harboring BRAF V600 mutation, although anti-PD1 antibodies appear to be less toxic. Further research is needed to increase the quality of evidence. Copyright © 2017 Elsevier Ltd. All rights reserved.

  20. Cost Minimization Analysis of Hypnotic Drug: Target Controlled Inhalation Anesthesia (TCIA Sevoflurane and Target Controlled Infusion (TCI Propofol

    Directory of Open Access Journals (Sweden)

    Made Wiryana

    2016-09-01

    Full Text Available Background: Cost minimization analysis is a pharmaco-economic study used to compare two or more health interventions that have been shown to have the same effect, similar or equivalent. With limited health insurance budget from the Indonesian National Social Security System implementation in 2015, the quality control and the drug cost are two important things that need to be focused. The application of pharmaco-economic study results in the selection and use of drugs more effectively and efficiently. Objective: To determine cost minimization analysis of hypnotic drug between a target controlled inhalation anesthesia (TCIA sevoflurane and a target controlled infusion (TCI propofol in patients underwent a major oncologic surgery in Sanglah General Hospital. Methods: Sixty ASA physical status I-II patients underwent major oncologic surgery were divided into two groups. Group A was using TCIA sevoflurane and group B using TCI propofol. Bispectral index monitor (BIS index was used to evaluate the depth of anesthesia. The statistical tests used are the Shapiro-Wilk test, Lavene test, Mann-Whitney U test and unpaired t-test (α = 0.05. The data analysis used the Statistical Package for Social Sciences (SPSS for Windows. Results: In this study, the rate of drug used per unit time in group A was 0.12 ml sevoflurane per minute (± 0.03 and the group B was 7.25 mg propofol per minute (±0.98. Total cost of hypnotic drug in group A was IDR598.43 (IQR 112.47 per minute, in group B was IDR703.27 (IQR 156.73 per minute (p>0.05. Conclusions: There was no statistically significant difference from the analysis of the drug cost minimization hypnotic drug in a major oncologic surgery using TCIA sevoflurane and TCI propofol.

  1. Deep situationality

    DEFF Research Database (Denmark)

    Matejskova, Tatiana

    2014-01-01

    as a Slovak national with immigration experi- ence, a nominal outsider to both the country of research, Germany, and its immigrant subjects, the post-Soviet Russian-speaking migrants. Focusing on the production of time-spaces of proximity as a deeply situational process, I stress in particular the un...

  2. International Spine Radiosurgery Consortium Consensus Guidelines for Target Volume Definition in Spinal Stereotactic Radiosurgery

    International Nuclear Information System (INIS)

    Cox, Brett W.; Spratt, Daniel E.; Lovelock, Michael; Bilsky, Mark H.; Lis, Eric; Ryu, Samuel; Sheehan, Jason; Gerszten, Peter C.; Chang, Eric; Gibbs, Iris; Soltys, Scott; Sahgal, Arjun; Deasy, Joe; Flickinger, John; Quader, Mubina; Mindea, Stefan

    2012-01-01

    Purpose: Spinal stereotactic radiosurgery (SRS) is increasingly used to manage spinal metastases. However, target volume definition varies considerably and no consensus target volume guidelines exist. This study proposes consensus target volume definitions using common scenarios in metastatic spine radiosurgery. Methods and Materials: Seven radiation oncologists and 3 neurological surgeons with spinal radiosurgery expertise independently contoured target and critical normal structures for 10 cases representing common scenarios in metastatic spine radiosurgery. Each set of volumes was imported into the Computational Environment for Radiotherapy Research. Quantitative analysis was performed using an expectation maximization algorithm for Simultaneous Truth and Performance Level Estimation (STAPLE) with kappa statistics calculating agreement between physicians. Optimized confidence level consensus contours were identified using histogram agreement analysis and characterized to create target volume definition guidelines. Results: Mean STAPLE agreement sensitivity and specificity was 0.76 (range, 0.67-0.84) and 0.97 (range, 0.94-0.99), respectively, for gross tumor volume (GTV) and 0.79 (range, 0.66-0.91) and 0.96 (range, 0.92-0.98), respectively, for clinical target volume (CTV). Mean kappa agreement was 0.65 (range, 0.54-0.79) for GTV and 0.64 (range, 0.54-0.82) for CTV (P<.01 for GTV and CTV in all cases). STAPLE histogram agreement analysis identified optimal consensus contours (80% confidence limit). Consensus recommendations include that the CTV should include abnormal marrow signal suspicious for microscopic invasion and an adjacent normal bony expansion to account for subclinical tumor spread in the marrow space. No epidural CTV expansion is recommended without epidural disease, and circumferential CTVs encircling the cord should be used only when the vertebral body, bilateral pedicles/lamina, and spinous process are all involved or there is extensive metastatic

  3. Intra-individual gait pattern variability in specific situations: Implications for forensic gait analysis.

    Science.gov (United States)

    Ludwig, Oliver; Dillinger, Steffen; Marschall, Franz

    2016-07-01

    In this study, inter- and intra-individual gait pattern differences are examined in various gait situations by means of phase diagrams of the extremity angles (cyclograms). 8 test subjects walked along a walking distance of 6m under different conditions three times each: barefoot, wearing sneakers, wearing combat boots, after muscular fatigue, and wearing a full-face motorcycle helmet restricting vision. The joint angles of foot, knee, and hip were recorded in the sagittal plane. The coupling of movements was represented by time-adjusted cyclograms, and the inter- and intra-individual differences were captured by calculating the similarity between different gait patterns. Gait pattern variability was often greater between the defined test situations than between the individual test subjects. The results have been interpreted considering neurophysiological regulation mechanisms. Footwear, masking, and fatigue were interpreted as disturbance parameters, each being a cause for gait pattern variability and complicating the inference of identity of persons in video recordings. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  4. Gaze-informed, task-situated representation of space in primate hippocampus during virtual navigation

    Science.gov (United States)

    Wirth, Sylvia; Baraduc, Pierre; Planté, Aurélie; Pinède, Serge; Duhamel, Jean-René

    2017-01-01

    To elucidate how gaze informs the construction of mental space during wayfinding in visual species like primates, we jointly examined navigation behavior, visual exploration, and hippocampal activity as macaque monkeys searched a virtual reality maze for a reward. Cells sensitive to place also responded to one or more variables like head direction, point of gaze, or task context. Many cells fired at the sight (and in anticipation) of a single landmark in a viewpoint- or task-dependent manner, simultaneously encoding the animal’s logical situation within a set of actions leading to the goal. Overall, hippocampal activity was best fit by a fine-grained state space comprising current position, view, and action contexts. Our findings indicate that counterparts of rodent place cells in primates embody multidimensional, task-situated knowledge pertaining to the target of gaze, therein supporting self-awareness in the construction of space. PMID:28241007

  5. Being similar while judging right and wrong: The effects of personal and situational similarity on moral judgements.

    Science.gov (United States)

    Pascal, Emilia

    2017-07-20

    This study investigated the effects of similarity with the transgressor and the victim on the perceived immorality of the transgression. Participants read two stories describing a person that cheated on their partner and a police officer that mistreated somebody. In the first story we manipulated participants' personal similarity to the transgressor and in the second their personal similarity to the victim. In each story, participants' past situational similarity to the target character was assessed according to their previous experiences of being in the same position. Results show that both personal and past situational similarity to the transgressor determine less severe moral judgements, while personal and past situational similarity with the victim have the opposite effect. We also tested several potential mediators of these effects, derived from competing theoretical accounts of the influence of similarity on perceived responsibility. Empathy emerged as mediating most of the effects of similarity on moral judgements, except those induced by past situational similarity with the victim. The foreseen probability of being in a similar situation mediated only the effects of similarity to the transgressor, and not those of similarity to the victim. Overall, results highlight the complex mechanisms of the influences of similarity on moral judgements. © 2017 International Union of Psychological Science.

  6. Modern principles of public administration of pharmaceutical supply for the population in emergency situations

    Directory of Open Access Journals (Sweden)

    P. V. Olіynуk

    2015-08-01

    Full Text Available In conditions of the emergency situations’ amount increasing the readiness of the state to provide affected people and all other segments of the population with full pharmaceutical provision is important. The aim of research is an analysis of the state of the legislative and regulatory framework of governmental administration by pharmaceutical provision of the population in the conditions of emergency situations. Materials and methods. We used methods of observation and synthesis, generalization and formalization, analysis of content. The object of the study were regulations, government pharmaceutical providing of population in emergency situations. Results. Studies show the need to develop methods and principles of public administration process to ensure people with pharmaceutical and specific methodological approaches in emergency situations. Conclusions. It has been established, that it is necessary to develop scientifically based methods of governance by the process of pharmaceutical providing the affected population.

  7. Retro-Techno-Economic Analysis: Using (Bio)Process Systems Engineering Tools to Attain Process Target Values

    DEFF Research Database (Denmark)

    Furlan, Felipe F.; Costa, Caliane B B; Secchi, Argimiro R.

    2016-01-01

    Economic analysis, allied to process systems engineering tools, can provide useful insights about process techno-economic feasibility. More interestingly, rather than being used to evaluate specific process conditions, this techno-economic analysis can be turned upside down to achieve target valu...

  8. The Power of Professionally Situated Practice Analysis in Redesigning Organisations: A Psychosociological Approach

    Science.gov (United States)

    Scaratti, Giuseppe; Gorli, Mara; Ripamonti, Silvio

    2009-01-01

    Purpose: This paper seeks to provoke thoughts around the possibility of using the lever of practices and situated knowledge to trigger organisational change and to redesign it with the involvement of the whole organisation. Design/methodology/approach: The paper presents connections between a psychosociological approach and a practice-based…

  9. The drug target genes show higher evolutionary conservation than non-target genes.

    Science.gov (United States)

    Lv, Wenhua; Xu, Yongdeng; Guo, Yiying; Yu, Ziqi; Feng, Guanglong; Liu, Panpan; Luan, Meiwei; Zhu, Hongjie; Liu, Guiyou; Zhang, Mingming; Lv, Hongchao; Duan, Lian; Shang, Zhenwei; Li, Jin; Jiang, Yongshuai; Zhang, Ruijie

    2016-01-26

    Although evidence indicates that drug target genes share some common evolutionary features, there have been few studies analyzing evolutionary features of drug targets from an overall level. Therefore, we conducted an analysis which aimed to investigate the evolutionary characteristics of drug target genes. We compared the evolutionary conservation between human drug target genes and non-target genes by combining both the evolutionary features and network topological properties in human protein-protein interaction network. The evolution rate, conservation score and the percentage of orthologous genes of 21 species were included in our study. Meanwhile, four topological features including the average shortest path length, betweenness centrality, clustering coefficient and degree were considered for comparison analysis. Then we got four results as following: compared with non-drug target genes, 1) drug target genes had lower evolutionary rates; 2) drug target genes had higher conservation scores; 3) drug target genes had higher percentages of orthologous genes and 4) drug target genes had a tighter network structure including higher degrees, betweenness centrality, clustering coefficients and lower average shortest path lengths. These results demonstrate that drug target genes are more evolutionarily conserved than non-drug target genes. We hope that our study will provide valuable information for other researchers who are interested in evolutionary conservation of drug targets.

  10. The drug-minded protein interaction database (DrumPID) for efficient target analysis and drug development.

    Science.gov (United States)

    Kunz, Meik; Liang, Chunguang; Nilla, Santosh; Cecil, Alexander; Dandekar, Thomas

    2016-01-01

    The drug-minded protein interaction database (DrumPID) has been designed to provide fast, tailored information on drugs and their protein networks including indications, protein targets and side-targets. Starting queries include compound, target and protein interactions and organism-specific protein families. Furthermore, drug name, chemical structures and their SMILES notation, affected proteins (potential drug targets), organisms as well as diseases can be queried including various combinations and refinement of searches. Drugs and protein interactions are analyzed in detail with reference to protein structures and catalytic domains, related compound structures as well as potential targets in other organisms. DrumPID considers drug functionality, compound similarity, target structure, interactome analysis and organismic range for a compound, useful for drug development, predicting drug side-effects and structure-activity relationships.Database URL:http://drumpid.bioapps.biozentrum.uni-wuerzburg.de. © The Author(s) 2016. Published by Oxford University Press.

  11. Analysis on Present Situation and Countermeasures of Rural Ecotourism in Jiangsu Province

    OpenAIRE

    WANG, Haiqin; GUAN, Yongxiang; WANG, Zichen

    2013-01-01

    This article briefly outlines the concept, present situation and form of rural ecotourism. It also preliminarily analyses the existing problems of rural ecotourism. Then countermeasures and suggestions related to the further development of rural ecotourism and the promotion of new countryside construction are put forward, which can be summarized as follows: carrying out multichannel financing, in order to strengthen the development dynamics of rural ecotourism; focusing on cultivation of ecol...

  12. [Euthanasia 2002-2014: The situation in Belgium].

    Science.gov (United States)

    Lossignol, D

    2016-10-01

    Since 2002, Belgian law has authorized the practice of euthanasia under certain clear conditions. All cases have to be reported to the Assessment and Control Commission (ACC). To date, more than 9000 cases have been reported. To make a statement about the Belgian experience requires consideration of several different essential points: detailed data and information from the ACC reports, their analysis, consequences on medical practice, problems experienced, legal and medical perspectives, criticism and attacks. The concept of individual and institutional conscience is also considered. Euthanasia for minors has been permitted since March 2014 but, to date, no case has been reported. In the light of what has happened in Belgium, we propose to analyse the legal situation in France. The Belgian experience is much more than an example and shows that, in difficult and painful situations, it is possible to meet the expectations of patients experiencing intolerable suffering with great respect and without imposing dogmatically something they do not wish. Copyright © 2015 SPLF. Published by Elsevier Masson SAS. All rights reserved.

  13. Connecting and separating mind-sets: culture as situated cognition.

    Science.gov (United States)

    Oyserman, Daphna; Sorensen, Nicholas; Reber, Rolf; Chen, Sylvia Xiaohua

    2009-08-01

    People perceive meaningful wholes and later separate out constituent parts (D. Navon, 1977). Yet there are cross-national differences in whether a focal target or integrated whole is first perceived. Rather than construe these differences as fixed, the proposed culture-as-situated-cognition model explains these differences as due to whether a collective or individual mind-set is cued at the moment of observation. Eight studies demonstrated that when cultural mind-set and task demands are congruent, easier tasks are accomplished more quickly and more difficult or time-constrained tasks are accomplished more accurately ( Koreans, Korean Americans; STUDY 2: Hong Kong Chinese; STUDY 3: European- and Asian-heritage Americans; STUDY 4: Americans; 5 Hong Kong Chinese; STUDY 6: Americans; STUDY 7: Norwegians; STUDY 8: African-, European-, and Asian-heritage Americans). Meta-analyses (d = .34) demonstrated homogeneous effects across geographic place (East-West), racial-ethnic group, task, and sensory mode-differences are cued in the moment. Contrast and separation are salient individual mind-set procedures, resulting in focus on a single target or main point. Assimilation and connection are salient collective mind-set procedures, resulting in focus on multiplicity and integration.

  14. Constructing catalogue of temporal situations

    Directory of Open Access Journals (Sweden)

    Violetta Koseska-Toszewa

    2015-11-01

    Full Text Available Constructing catalogue of temporal situations The paper is aiming to create a common basis for description, comparing, and analysis natural languages. As a subject of comparison we have chosen temporal structures of some languages. For such a choice there exists a perfect tool, describing basic temporal phenomena, namely an ordering of states and events in time, certainty and uncertainty, independency of histories of separate objects, necessity and possibility. This tool is supported by the Petri nets formalism, which seems to be well suited for expressing the above mentioned phenomena. Petri nets are built form three primitive notions: of states, of events that begin or end the states, and so-called flow relation indicating succession of states and events. This simple constituents give rise to many possibilities of representing temporal phenomena; it turns out that such representations are sufficient for many (clearly, not necessarily all temporal situations appearing in natural languages. In description formalisms used till now there is no possibility of expressing such reality phenomena as temporal dependencies in compound statement, or combination of temporality and modality. Moreover, using these formalisms one cannot distinguish between two different sources of uncertainty of the speaker while describing the reality: one, due to the lack of knowledge of the speaker what is going on in outside world, the second, due to objective impossibility of foreseen ways in which some conflict situations will be (or already have been resolved. Petri net formalism seems to be perfectly suited for such differentiations. There are two main description principles that encompassed this paper. First, that assigns meaning to names of grammatical structures in different languages may lead to misunderstanding. Two grammatical structures with apparently close names may describe different reality. Additionally, some grammatical terms used in one language may be

  15. Components of Task-Based Needs Analysis of the ESP Learners with the Specialization of Business and Tourism

    Science.gov (United States)

    Poghosyan, Naira

    2016-01-01

    In the following paper we shall thoroughly analyze the target learning needs of the learners within an ESP (English for Specific Purposes) context. The main concerns of ESP have always been and remain with the needs analysis, text analysis and preparing learners to communicate effectively in the tasks prescribed by their study or work situation.…

  16. Changing paradigm from one target one ligand towards multi target directed ligand design for key drug targets of Alzheimer disease: An important role of Insilco methods in multi target directed ligands design.

    Science.gov (United States)

    Kumar, Akhil; Tiwari, Ashish; Sharma, Ashok

    2018-03-15

    Alzheimer disease (AD) is now considered as a multifactorial neurodegenerative disorder and rapidly increasing to an alarming situation and causing higher death rate. One target one ligand hypothesis is not able to provide complete solution of AD due to multifactorial nature of disease and one target one drug seems to fail to provide better treatment against AD. Moreover, current available treatments are limited and most of the upcoming treatments under clinical trials are based on modulating single target. So the current AD drug discovery research shifting towards new approach for better solution that simultaneously modulate more than one targets in the neurodegenerative cascade. This can be achieved by network pharmacology, multi-modal therapies, multifaceted, and/or the more recently proposed term "multi-targeted designed drugs. Drug discovery project is tedious, costly and long term project. Moreover, multi target AD drug discovery added extra challenges such as good binding affinity of ligands for multiple targets, optimal ADME/T properties, no/less off target side effect and crossing of the blood brain barrier. These hurdles may be addressed by insilico methods for efficient solution in less time and cost as computational methods successfully applied to single target drug discovery project. Here we are summarizing some of the most prominent and computationally explored single target against AD and further we discussed successful example of dual or multiple inhibitors for same targets. Moreover we focused on ligand and structure based computational approach to design MTDL against AD. However is not an easy task to balance dual activity in a single molecule but computational approach such as virtual screening docking, QSAR, simulation and free energy are useful in future MTDLs drug discovery alone or in combination with fragment based method. However, rational and logical implementations of computational drug designing methods are capable of assisting AD drug

  17. Advanced Situation Awareness Technologies, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Advanced Situation Awareness Technologies (ASAT) will facilitate exploration of the moon surface, and other planetary bodies. ASAT will create an Advanced Situation...

  18. Effect of Situational Factors and Product on Consumer Buying Decision In Hypermart at Manado City

    Directory of Open Access Journals (Sweden)

    Nova Christian Mamuaya

    2016-06-01

    Full Text Available This research aims at (1 understanding and analyzing the effect of situational and non situational (produc factors, simultaneously or partially, on the consumer buying decision in hypermart at Manado City, (2 understanding and analyzing factor with dominant effect on consumer buying decision in hypermart at Manado City. The observed situational and non situational (product factors through Belk Theory. Sampling has been developed through accidental sampling, resulting in 60 respondents. Data  have  been  collected  by main instrument of questionnaire, 5-point Likert Scale to measure the respondents’ answer, data analysis using multiple linier regression. Results of research indicate that situational factor and product have significant effect simultaneously or partially on consumer buying decisions in hypermart at Manado City and product assortment has dominant effect on consumer buying decision in hypermart at Manado City.

  19. Single-cell analysis of targeted transcriptome predicts drug sensitivity of single cells within human myeloma tumors.

    Science.gov (United States)

    Mitra, A K; Mukherjee, U K; Harding, T; Jang, J S; Stessman, H; Li, Y; Abyzov, A; Jen, J; Kumar, S; Rajkumar, V; Van Ness, B

    2016-05-01

    Multiple myeloma (MM) is characterized by significant genetic diversity at subclonal levels that have a defining role in the heterogeneity of tumor progression, clinical aggressiveness and drug sensitivity. Although genome profiling studies have demonstrated heterogeneity in subclonal architecture that may ultimately lead to relapse, a gene expression-based prediction program that can identify, distinguish and quantify drug response in sub-populations within a bulk population of myeloma cells is lacking. In this study, we performed targeted transcriptome analysis on 528 pre-treatment single cells from 11 myeloma cell lines and 418 single cells from 8 drug-naïve MM patients, followed by intensive bioinformatics and statistical analysis for prediction of proteasome inhibitor sensitivity in individual cells. Using our previously reported drug response gene expression profile signature at the single-cell level, we developed an R Statistical analysis package available at https://github.com/bvnlabSCATTome, SCATTome (single-cell analysis of targeted transcriptome), that restructures the data obtained from Fluidigm single-cell quantitative real-time-PCR analysis run, filters missing data, performs scaling of filtered data, builds classification models and predicts drug response of individual cells based on targeted transcriptome using an assortment of machine learning methods. Application of SCATT should contribute to clinically relevant analysis of intratumor heterogeneity, and better inform drug choices based on subclonal cellular responses.

  20. The study of disaster situation awareness based on volunteered geographic information

    Science.gov (United States)

    Zhao, Qiansheng; Chen, Zi; Li, Shengming; Luo, Nianxue

    2015-12-01

    As the development of Web 2.0, the social media like microblog, blogs and social network have supplied a bunch of information with locations (Volunteered Geographical Information, VGI).Recent years many cases have shown that, if disaster happened, the cyber citizens will get together very quickly and share the disaster information, this results a bunch of volunteered geographical information about disaster situation which is very valuable for disaster response if this VGIs are used efficiently and properly. This project will take typhoon disaster as case study. In this paper, we study the relations between weibo messages and the real typhoon situation, we proposed an analysis framework for mine the relations between weibo messages distribution and physical space. We found that the number of the weibo messages, key words frequency and spatial temporary distribution of the messages have strong relations with the disaster spread in the real world, and this research results can improve our disaster situation awareness in the future. The achievement of the study will give a method for typhoon disaster situation awareness based on VGI from the bottom up, and will locate the disaster spot and evolution quickly which is very important for disaster response and recover.

  1. Analytical models for development of high performance metal targets irradiated in IPEN-CNEN/SP Cyclone 30 and Cyclone 18 cyclotrons

    International Nuclear Information System (INIS)

    Oliveira, Henrique Barcellos de

    2009-01-01

    Analytical models were developed that describe the basic elements for metal targets irradiation in cyclotrons. Important parameters such as maximum beam current value and thermal power deposited on target were obtained and compared with practical situations. In an unprecedented way, were determined analytically the features found in intense thermal transient situations, when high protons concentrations in a small region of the beam cause intense temperature gradients in small regions of the target. Comparing with results found in the literature showed that the developed models are satisfactory, in view of all limitations of the proposed model. (author)

  2. HIV/AIDS National Strategic Plans of Sub-Saharan African countries: an analysis for gender equality and sex-disaggregated HIV targets.

    Science.gov (United States)

    Sherwood, Jennifer; Sharp, Alana; Cooper, Bergen; Roose-Snyder, Beirne; Blumenthal, Susan

    2017-12-01

    National Strategic Plans (NSPs) for HIV/AIDS are country planning documents that set priorities for programmes and services, including a set of targets to quantify progress toward national and international goals. The inclusion of sex-disaggregated targets and targets to combat gender inequality is important given the high disease burden among young women and adolescent girls in Sub-Saharan Africa, yet no comprehensive gender-focused analysis of NSP targets has been performed. This analysis quantitatively evaluates national HIV targets, included in NSPs from eighteen Sub-Saharan African countries, for sex-disaggregation. Additionally, NSP targets aimed at reducing gender-based inequality in health outcomes are compiled and inductively coded to report common themes. On average, in the eighteen countries included in this analysis, 31% of NSP targets include sex-disaggregation (range 0-92%). Three countries disaggregated a majority (>50%) of their targets by sex. Sex-disaggregation in data reporting was more common for targets related to the early phases of the HIV care continuum: 83% of countries included any sex-disaggregated targets for HIV prevention, 56% for testing and linkage to care, 22% for improving antiretroviral treatment coverage, and 11% for retention in treatment. The most common target to reduce gender inequality was to prevent gender-based violence (present in 50% of countries). Other commonly incorporated target areas related to improving women's access to family planning, human and legal rights, and decision-making power. The inclusion of sex-disaggregated targets in national planning is vital to ensure that programmes make progress for all population groups. Improving the availability and quality of indicators to measure gender inequality, as well as evaluating programme outcomes by sex, is critical to tracking this progress. This analysis reveals an urgent need to set specific and separate targets for men and women in order to achieve an equitable

  3. HIV/AIDS National Strategic Plans of Sub-Saharan African countries: an analysis for gender equality and sex-disaggregated HIV targets

    Science.gov (United States)

    Sherwood, Jennifer; Sharp, Alana; Cooper, Bergen; Roose-Snyder, Beirne; Blumenthal, Susan

    2017-01-01

    Abstract National Strategic Plans (NSPs) for HIV/AIDS are country planning documents that set priorities for programmes and services, including a set of targets to quantify progress toward national and international goals. The inclusion of sex-disaggregated targets and targets to combat gender inequality is important given the high disease burden among young women and adolescent girls in Sub-Saharan Africa, yet no comprehensive gender-focused analysis of NSP targets has been performed. This analysis quantitatively evaluates national HIV targets, included in NSPs from eighteen Sub-Saharan African countries, for sex-disaggregation. Additionally, NSP targets aimed at reducing gender-based inequality in health outcomes are compiled and inductively coded to report common themes. On average, in the eighteen countries included in this analysis, 31% of NSP targets include sex-disaggregation (range 0–92%). Three countries disaggregated a majority (>50%) of their targets by sex. Sex-disaggregation in data reporting was more common for targets related to the early phases of the HIV care continuum: 83% of countries included any sex-disaggregated targets for HIV prevention, 56% for testing and linkage to care, 22% for improving antiretroviral treatment coverage, and 11% for retention in treatment. The most common target to reduce gender inequality was to prevent gender-based violence (present in 50% of countries). Other commonly incorporated target areas related to improving women’s access to family planning, human and legal rights, and decision-making power. The inclusion of sex-disaggregated targets in national planning is vital to ensure that programmes make progress for all population groups. Improving the availability and quality of indicators to measure gender inequality, as well as evaluating programme outcomes by sex, is critical to tracking this progress. This analysis reveals an urgent need to set specific and separate targets for men and women in order to achieve

  4. Exploring the “Situation” of Situational Willingness to Communicate: A Volunteer Youth Exchange Perspective

    Directory of Open Access Journals (Sweden)

    Callie Mady

    2010-06-01

    Full Text Available This paper presents the perspectives of youth participating in the Society for Educational Visits and Exchanges in Canada's Volunteer Youth Experience (VYE as gathered by way of pre- and post-program questionnaires, observations, interviews, and journals. The pan-Canadian questionnaire results suggest that this short, bilingual volunteer experience enhances participant motivation to learn a second official language and to be part of the target community. Triangulated findings from observations, interviews and journals indicate that participants' willingness to communicate (WTC in the second language (MacIntyre, Dörnyei, Clément, & Noels, 1998 may have been influenced by situational factors inherent to the volunteer experience such as access to native speakers of the target language and opportunities for authentic community participation.

  5. Analysis of the world epidemiological situation among vancomycin-resistant Enterococcus faecium infections and the current situation in Poland

    Science.gov (United States)

    Talaga-Ćwiertnia, Katarzyna; Bulanda, Małgorzata

    2018-01-01

    Vancomycin-resistant Enterococcus faecium (VREfm) strains have become an important hospital pathogen due to their rapid spread, high mortality rate associated with infections and limited therapeutic options. Vancomycin resistance is predominantly mediated by VanA or VanB phenotypes, which differ as regards maintaining sensitivity to teicoplanin in the VanB phenotype. The majority of VREfm cases in the United States, Europe, Korea, South America and Africa are currently caused by the VanA phenotype. However, the epidemics in Australia and Singapore are chiefly brought about by the VanB phenotype. The rate of VREfm isolate spread varies greatly. The greatest percentage of VREfm is now recorded in the USA, Ireland and Australia. Supervision of VRE is implemented to varying degrees. Therefore, the epidemiological situation in some countries is difficult to assess due to limited data or lack thereof.

  6. HRA Data Collection from the Simulations of Abnormal Situations

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yo Chan; Park, Jink Yun; Jung, Won Dea [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-10-15

    In this study, it was revealed that the designed worksheets were feasible to collect HRA data, especially in abnormal situations. The defined taxonomy of UAs was unambiguous to distinguish actions of operators and quantify the probabilities. It is widely recognized that reliability of operators are critical to complex socio-technical systems. For this reason, human reliability analysis (HRA), which aims to identify unsafe actions (UAs) that contribute to risks of the systems and assess the failure rates of the actions, has been conducted. Although many techniques of HRA have been developed and used in many years, many reports indicated lack of database for supporting empirical bases of HRA methods. Thus, there have been recent efforts to collect data about human reliability from plant experience, simulator experiment or qualification, and laboratory experiments. As one of these efforts, KAERI also established a guideline to collect information about human reliability and performance shaping factors from simulators. This guideline particularly presented a set of worksheets that allows comprehensively gathering objectively observable information in simulations of emergency situations. This paper reports the process and preliminary results of the data collection from the simulations of abnormal situations based on the developed worksheets in KAERI database guideline. We analyzed operator behaviors of the sixteen experiments for the two kinds of abnormal situations: RCP (reactor coolant pump) cyclone filter blockage and CDP (condensate pump) valve stuck. The UAs of operators were identified and quantified. Because the number of simulations was limited and data of various situations will be obtained continuously, it is uncertain to conclude the resulted probabilities. Based on the worksheet, operator behaviors in many different kinds of scenarios will be analyzed and the relations between human reliabilities and the observed factors will be also investigated.

  7. Determination of thermal-hydraulic loads on reactor internals in a DBA-situation

    International Nuclear Information System (INIS)

    Ville Lestinen; Timo Toppila

    2005-01-01

    Full text of publication follows: According to Finnish regulatory requirements, reactor internals have to stay intact in a design basis accident (DBA) situation, so that control rods can still penetrate into the core. To fulfill this demand some criteria must be followed in periodical in-service inspections. This is the motivation for studying and developing more detailed methods for analysis of thermal-hydraulic loads on reactor internals during the DBA-situation for the Loviisa NPP in Finland. The objective of this research program is to connect thermal-hydraulic and mechanical analysis methods with the goal to produce a reliable method for determination of thermal-hydraulic and mechanical loads on reactor internals in the accident situation. The tools studied are thermal-hydraulic system codes, computational fluid dynamics (CFD) codes and finite element analysis (FEA) codes. This paper concentrates mainly on thermal-hydraulic part of the research, but also the mechanical aspects are discussed. Firstly, the paper includes a short literary review of the available methods to analyse the described problem including both thermal-hydraulic and structural analysis parts. Secondly, different possibilities to carry out thermal-hydraulic analyses have been studied. The DBA-case includes complex physical phenomena and therefore modelling is difficult. The accident situation can be for example LLOCA. When the pipe has broken, the pressure decreases and water starts to evaporate, which consumes energy and that way limits the pressure decrease. After some period of time, the system reaches a new equilibrium state. To perform exact thermal-hydraulic analysis also two phase phenomena must be included. Therefore CFD codes are not capable of modelling the DBA situation very well, but the use of CFD codes requires that the effect of two phase flow must be added somehow. One method to calculate two phase phenomena with CFD codes is to use thermal-hydraulic system codes to calculate

  8. Emergency situations in SMEs : Are entrepreneurs prepared?

    NARCIS (Netherlands)

    Kleijn, E.; Montfort, van K.; Masurel, E.

    2012-01-01

    The article examines how entrepreneurs prepare for emergency situations in small and medium-sized enterprises (SMEs) in the Netherlands. It identifies the characteristics of SMEs and the theory related to emergency situations and the preparations for such situations. It also provides a detailed

  9. [Food and nutritional security: situation analysis of decentralization in the national public policy].

    Science.gov (United States)

    Vasconcellos, Ana Beatriz Pinto de Almeida; Moura, Leides Barroso Azevedo de

    2018-03-01

    The aim of this study was to analyze the situation with the decentralization of the Brazilian National System of Food and Nutritional Security (SISAN), created in 2006 under the Brazilian National Food and Nutritional Security Act (LOSAN). Based on the criteria for joining SISAN, as set out in Decree 7,272 of August 25, 2010, the authors analyzed data from the basic information surveys of the Brazilian Institute of Geography and Statistics, 2014 (Estadic e Munic/2014). The results show that decentralization of SISAN is still incipient at the municipal level, although all the states of Brazil have already joined the system. The social assistance sector has played an outstanding role in coordinating SISAN at the state and municipal levels, while in the latter the health sector has also played a relevant role. The analysis of food and nutritional security activities conducted to date, based on the sources of federal, state, and municipal funds, further shows that the federal sphere has still not played a strong inductive role capable of leading the expansion of SISAN. More effective funding mechanisms and the assignment of responsibilities to the states and municipalities are relevant factors for consolidating the system's state-level base and expanding the municipal base in the search for an identity and capillarity for SISAN.

  10. Understanding Social Situations (USS): A proof-of-concept social-cognitive intervention targeting theory of mind and attributional bias in individuals with psychosis.

    Science.gov (United States)

    Fiszdon, Joanna M; Roberts, David L; Penn, David L; Choi, Kee-Hong; Tek, Cenk; Choi, Jimmy; Bell, Morris D

    2017-03-01

    In this proof-of-concept trial, we examined the feasibility and preliminary efficacy of Understanding Social Situations (USS), a new social-cognitive intervention that targets higher level social-cognitive skills using methods common to neurocognitive remediation, including drill and practice and hierarchically structured training, which may compensate for the negative effects of cognitive impairment on learning. Thirty-eight individuals with schizophrenia spectrum disorders completed the same baseline assessment of cognitive and social-cognitive functioning twice over a 1-month period to minimize later practice effects, then received 7-10 sessions of USS training, and then completed the same assessment again at posttreatment. USS training was well tolerated and received high treatment satisfaction ratings. Large improvements on the USS Skills Test, which contained items similar to but not identical to training stimuli, suggest that we were effective in teaching specific training content. Content gains generalized to improvements on some of the social-cognitive tasks, including select measures of attributional bias and theory of mind. Importantly, baseline neurocognition did not impact the amount of learning during USS (as indexed by the USS Skills Test) or the amount of improvement on social-cognitive measures. USS shows promise as a treatment for higher level social-cognitive skills. Given the lack of relationship between baseline cognition and treatment effects, it may be particularly appropriate for individuals with lower range cognitive function. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  11. The value of instructional communication in crisis situations: restoring order to chaos.

    Science.gov (United States)

    Sellnow, Timothy L; Sellnow, Deanna D; Lane, Derek R; Littlefield, Robert S

    2012-04-01

    This article explores the nature of instructional communication in responding to crisis situations. Through the lens of chaos theory, the relevance of instructional messages in restoring order is established. This perspective is further advanced through an explanation of how various learning styles impact the receptivity of various instructional messages during the acute phase of crises. We then summarize an exploratory study focusing on the relationship between learning styles and the demands of instructional messages in crisis situations. We conclude the article with a series of conclusions and implications. © 2011 Society for Risk Analysis.

  12. An assessment of independent component analysis for detection of military targets from hyperspectral images

    Science.gov (United States)

    Tiwari, K. C.; Arora, M. K.; Singh, D.

    2011-10-01

    Hyperspectral data acquired over hundreds of narrow contiguous wavelength bands are extremely suitable for target detection due to their high spectral resolution. Though spectral response of every material is expected to be unique, but in practice, it exhibits variations, which is known as spectral variability. Most target detection algorithms depend on spectral modelling using a priori available target spectra In practice, target spectra is, however, seldom available a priori. Independent component analysis (ICA) is a new evolving technique that aims at finding out components which are statistically independent or as independent as possible. The technique therefore has the potential of being used for target detection applications. A assessment of target detection from hyperspectral images using ICA and other algorithms based on spectral modelling may be of immense interest, since ICA does not require a priori target information. The aim of this paper is, thus, to assess the potential of ICA based algorithm vis a vis other prevailing algorithms for military target detection. Four spectral matching algorithms namely Orthogonal Subspace Projection (OSP), Constrained Energy Minimisation (CEM), Spectral Angle Mapper (SAM) and Spectral Correlation Mapper (SCM), and four anomaly detection algorithms namely OSP anomaly detector (OSPAD), Reed-Xiaoli anomaly detector (RXD), Uniform Target Detector (UTD) and a combination of Reed-Xiaoli anomaly detector and Uniform Target Detector (RXD-UTD) were considered. The experiments were conducted using a set of synthetic and AVIRIS hyperspectral images containing aircrafts as military targets. A comparison of true positive and false positive rates of target detections obtained from ICA and other algorithms plotted on a receiver operating curves (ROC) space indicates the superior performance of the ICA over other algorithms.

  13. Memory for target height is scaled to observer height.

    Science.gov (United States)

    Twedt, Elyssa; Crawford, L Elizabeth; Proffitt, Dennis R

    2012-04-01

    According to the embodied approach to visual perception, individuals scale the environment to their bodies. This approach highlights the central role of the body for immediate, situated action. The present experiments addressed whether body scaling--specifically, eye-height scaling--occurs in memory when action is not immediate. Participants viewed standard targets that were either the same height as, taller than, or shorter than themselves. Participants then viewed a comparison target and judged whether the comparison was taller or shorter than the standard target. Participants were most accurate when the standard target height matched their own heights, taking into account postural changes. Participants were biased to underestimate standard target height, in general, and to push standard target height away from their own heights. These results are consistent with the literature on eye-height scaling in visual perception and suggest that body scaling is not only a useful metric for perception and action, but is also preserved in memory.

  14. Normalization and Personalization of Learning Situation: NPLS

    Directory of Open Access Journals (Sweden)

    Mounia Abik

    2009-06-01

    Full Text Available The personalization of learning is a major pedagogical challenge solicited by pedagogues and didacts. There are several projects about the production of personalizable learning situations such as Reload-LDE and Alfanet. These projects are interested in producing new standardized and personalizable learning situations. However, on the Web, an important number of learning situations exist. These situations are rich in information but don't consider all the characteristics of participants taking part in the learning, nor their technical environments. In this paper we suggest a help system that can transform an existing learning situation to another structure standardized and personalizable depending on the context of learning personalization that we have defined.

  15. Situational leadership and persons with disabilities.

    Science.gov (United States)

    Cubero, Christopher G

    2007-01-01

    Does situational leadership style impact workers with disabilities? Situational leadership as a model and style of organizational management is defined. With a concentration on workers with disabilities, employer and employee perceptions of the workplace environment are analyzed as a contributing factor to the choice of leadership styles. Leadership style and its potential impact on workers with disabilities are included. Advantages of situational leadership style as an organizational model for managers that matches the intricate needs of workers with disabilities are argued. Methods for increasing awareness of the needs of persons with disabilities in the workplace and improving leadership models are discussed. Implications and potential outcomes for workers with disabilities based on the use of situational leadership by managers are discussed.

  16. Facilitators and barriers to quality of care in maternal, newborn and child health: a global situational analysis through metareview.

    Science.gov (United States)

    Nair, Manisha; Yoshida, Sachiyo; Lambrechts, Thierry; Boschi-Pinto, Cynthia; Bose, Krishna; Mason, Elizabeth Mary; Mathai, Matthews

    2014-05-22

    Conduct a global situational analysis to identify the current facilitators and barriers to improving quality of care (QoC) for pregnant women, newborns and children. Metareview of published and unpublished systematic reviews and meta-analyses conducted between January 2000 and March 2013 in any language. Assessment of Multiple Systematic Reviews (AMSTAR) is used to assess the methodological quality of systematic reviews. Health systems of all countries. Study outcome: QoC measured using surrogate indicators--effective, efficient, accessible, acceptable/patient centred, equitable and safe. Conducted in two phases (1) qualitative synthesis of extracted data to identify and group the facilitators and barriers to improving QoC, for each of the three population groups, into the six domains of WHO's framework and explore new domains and (2) an analysis grid to map the common facilitators and barriers. We included 98 systematic reviews with 110 interventions to improve QoC from countries globally. The facilitators and barriers identified fitted the six domains of WHO's framework--information, patient-population engagement, leadership, regulations and standards, organisational capacity and models of care. Two new domains, 'communication' and 'satisfaction', were generated. Facilitators included active and regular interpersonal communication between users and providers; respect, confidentiality, comfort and support during care provision; engaging users in decision-making; continuity of care and effective audit and feedback mechanisms. Key barriers identified were language barriers in information and communication; power difference between users and providers; health systems not accounting for user satisfaction; variable standards of implementation of standard guidelines; shortage of resources in health facilities and lack of studies assessing the role of leadership in improving QoC. These were common across the three population groups. The barriers to good

  17. Neutron performance analysis for ESS target proposal

    International Nuclear Information System (INIS)

    Magán, M.; Terrón, S.; Thomsen, K.; Sordo, F.; Perlado, J.M.; Bermejo, F.J.

    2012-01-01

    In the course of discussing different target types for their suitability in the European Spallation Source (ESS) one main focus was on neutronics' performance. Diverse concepts have been assessed baselining some preliminary engineering and geometrical details and including some optimization. With the restrictions and resulting uncertainty imposed by the lack of detailed designs optimizations at the time of compiling this paper, the conclusion drawn is basically that there is a little difference in the neutronic yield of the investigated targets. Other criteria like safety, environmental compatibility, reliability and cost will thus dominate the choice of an ESS target.

  18. Ethiopia - energy situation 1983/84

    Energy Technology Data Exchange (ETDEWEB)

    1985-01-01

    After a few short remarks on the energy situation, the most important figures referring to the production and consumption of electricity, petroleum, and petroleum products from 1978 to 1982 are compared in tabular form. The situation on the energy market, especially the petroleum and natural gas market, is described. Finally, some figures concerning the foreign trade are given.

  19. Design study and heat transfer analysis of a neutron converter target for medical radioisotope production

    International Nuclear Information System (INIS)

    Masoud Behzad; Sang-In Bak; Seung-Woo Hong; Jong-Seo Chai; Yacine Kadi; Claudio Tenreiro; University of Talca, Talca

    2014-01-01

    A worldwide challenge in the near future will be to find a way of producing radioisotopes in sufficient quantity without relying on research reactors. The motivation for this innovative work on targets lies in the accelerator-based production of radioisotopes using a neutron converter target as in the transmutation by adiabatic resonance crossing concept. Thermal analysis of a multi-channel helium cooled device is performed with the computational fluid dynamics code CFX. Different boundary conditions are taken into account in the simulation process and many important parameters such as maximum allowable solid target temperature as well as uniform inlet velocity and outlet pressure changes in the channels are investigated. The results confirm that the cooling configuration works well; hence such a solid target could be operated safely and may be considered for a prototype target. (author)

  20. Malware Analysis: From Large-Scale Data Triage to Targeted Attack Recognition (Dagstuhl Seminar 17281)

    OpenAIRE

    Zennou, Sarah; Debray, Saumya K.; Dullien, Thomas; Lakhothia, Arun

    2018-01-01

    This report summarizes the program and the outcomes of the Dagstuhl Seminar 17281, entitled "Malware Analysis: From Large-Scale Data Triage to Targeted Attack Recognition". The seminar brought together practitioners and researchers from industry and academia to discuss the state-of-the art in the analysis of malware from both a big data perspective and a fine grained analysis. Obfuscation was also considered. The meeting created new links within this very diverse community.

  1. Identification of putative drug targets in Vancomycin-resistant Staphylococcus aureus (VRSA) using computer aided protein data analysis.

    Science.gov (United States)

    Hasan, Md Anayet; Khan, Md Arif; Sharmin, Tahmina; Hasan Mazumder, Md Habibul; Chowdhury, Afrin Sultana

    2016-01-01

    Vancomycin-resistant Staphylococcus aureus (VRSA) is a Gram-positive, facultative aerobic bacterium which is evolved from the extensive exposure of Vancomycin to Methicillin resistant S. aureus (MRSA) that had become the most common cause of hospital and community-acquired infections. Due to the emergence of different antibiotic resistance strains, there is an exigency to develop novel drug targets to address the provocation of multidrug-resistant bacteria. In this study, in-silico genome subtraction methodology was used to design potential and pathogen specific drug targets against VRSA. Our study divulged 1987 proteins from the proteome of 34,549 proteins, which have no homologues in human genome after sequential analysis through CD-HIT and BLASTp. The high stringency analysis of the remaining proteins against database of essential genes (DEG) resulted in 169 proteins which are essential for S. aureus. Metabolic pathway analysis of human host and pathogen by KAAS at the KEGG server sorted out 19 proteins involved in unique metabolic pathways. 26 human non-homologous membrane-bound essential proteins including 4 which were also involved in unique metabolic pathway were deduced through PSORTb, CELLO v.2.5, ngLOC. Functional classification of uncharacterized proteins through SVMprot derived 7 human non-homologous membrane-bound hypothetical essential proteins. Study of potential drug target against Drug Bank revealed pbpA-penicillin-binding protein 1 and hypothetical protein MQW_01796 as the best drug target candidate. 2D structure was predicted by PRED-TMBB, 3D structure and functional analysis was also performed. Protein-protein interaction network of potential drug target proteins was analyzed by using STRING. The identified drug targets are expected to have great potential for designing novel drugs against VRSA infections and further screening of the compounds against these new targets may result in the discovery of novel therapeutic compounds that can be

  2. Analyses of transient plant response under emergency situations

    Energy Technology Data Exchange (ETDEWEB)

    Koyama, Kazuya [Advanced Reactor Technology, Co. Ltd., Engineering Department, Tokyo (Japan); Shimakawa, Yoshio; Hishida, Masahiko [Mitsubishi Heavy Industry, Ltd., Reactor Core Engineering and Safety Engineering Department, Tokyo (Japan)

    1999-03-01

    In order to support development of the dynamic reliability analysis program DYANA, analyses were made on the event sequences anticipated under emergency situations using the plant dynamics simulation computer code Super-COPD. The analytical models were developed for Super-COPD such as the guard vessel, the maintenance cooling system, the sodium overflow and makeup system, etc. in order to apply the code to the simulation of the emergency situations. The input data were prepared for the analyses. About 70 sequences were analyzed, which are categorized into the following events: (1) PLOHS (Protected Loss of Heat Sink), (2) LORL (Loss of Reactor Level)-J: failure of sodium makeup by the primary sodium overflow and makeup system, (3) LORL-G : failure of primary coolant pump trip, (4) LORL-I: failure of the argon cover gas isolation, and (5) heat removal only using the ventilation system of the primary cooling system rooms. The results were integrated into an input file for preparing the functions for the neural network simulation. (author)

  3. School and Situated Knowledge: Travel or Tourism?

    Science.gov (United States)

    Damarin, Suzanne K.

    1993-01-01

    Examines issues related to situated cognition and learning, both in the classroom and in the world. Topics discussed include educational theories; the situated nature of knowledge; the perception of experts; and the role of technology in situated learning, including virtual reality, hypertext, and telecommunications. (26 references) (LRW)

  4. AN ANALYSIS OF THE INTENTION TO PURCHASE ON THE COLLECTIVE BUYING WEBSITES THROUGH PSYCHOLOGICAL, SOCIOCULTURAL AND SITUATIONAL FACTORS

    Directory of Open Access Journals (Sweden)

    Erivaldo Lopes de Souza

    2017-10-01

    Full Text Available DOI: 10.12957/cadest.2017.25443 This article proposes to use empirical models, with good adjustment, that can provide an informative measure on the intention to buy consumers considering information about socio-cultural, psychological and situational factors associated with them. It is expected that a measure of probability provided by a model such as that proposed can be useful in strategic marketing decisions where consumers' intention to buy.To achieve the objective, initially interviewed 384 Internet users in places with large circulation of people the city of João Pessoa, Paraíba, Brazil. Then the data obtained from interviews, were used to estimate those models.  These models were based on assumptions of theories of the cognitive approach of consumer behavior, especially the Theory of Reasoned Action. The instrument used for data collection was a questionnaire containing market research questions related to psychological factors, sociocultural and situational consumer. The analysis considered only regression models of the class of generalized additive models.The most successful model presented nine variables and a single non-parametric term, obtained from smoothing splines. This model had a pseudo-R2of 0,89 and allowed to reach a percentage of correct trials of the observations of the sample equal to 94%. Keywords: Purchases intention, Regression model, Generalized Aditive Models, Consumer Behavior.

  5. Sistema automatizado para el análisis de la situación de salud Automated system for analysis of health situation

    Directory of Open Access Journals (Sweden)

    Agustín Paramio Rodríguez

    2011-09-01

    Full Text Available INTRODUCCIÓN: El análisis de la situación de salud es una práctica necesaria en la atención primaria de salud. Entre las principales dificultades para realizarlo se destaca la falta de habilidades por parte de los miembros del equipo básico de salud para el procesamiento de la información y por ende para la construcción de los indicadores necesarios, lo que resta calidad a los informes. OBJETIVOS: Proponer un sistema automatizado para la consolidación de la información estadística relacionada con el estado de salud de la población necesaria para la realización del análisis de la situación de salud. MÉTODOS: Se realizó una investigación de innovación tecnológica, que consistió en el diseño de un sistema automatizado para el procesamiento de la información estadística. Para esto se realizó una revisión de las guías existentes además de consultas a expertos. Se utilizaron las herramientas para tabulación de información y fórmulas que ofrece el programa Excel del paquete Microsoft Office 2007. RESULTADOS: Se propone el presente sistema cuya característica principal es la simplicidad de su uso. Este contribuye a organizar y facilitar el procesamiento de la información estadística tanto a nivel individual en el consultorio como a nivel del área de salud; permite ahorrar tiempo y recursos. CONCLUSIONES: Contribuye de manera efectiva a facilitar la tarea de nuestros profesionales en la tabulación y cálculo de los indicadores necesarios para la realización del análisis de la situación de salud del consultorio y del policlínico.INTRODUCTION: The analysis of health situation is a practice fundamental in the primary health care. Among the main difficulties to perform the analysis of health situation is the lack of abilities by health basic staff members for the information processing and therefore for the creation of necessary indicators playing down the quality of reports. OBJECTIVES: To propose an automated system

  6. 21 CFR 290.10 - Definition of emergency situation.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Definition of emergency situation. 290.10 Section...) DRUGS: GENERAL CONTROLLED DRUGS General Provisions § 290.10 Definition of emergency situation. For the... Controlled Substances Act, the term emergency situation means those situations in which the prescribing...

  7. Inventory of stress situations in nuclear power plants

    International Nuclear Information System (INIS)

    Saint-Jean, T.

    1986-04-01

    Anxious to pursue an in-depth analysis of stress phenomena in nuclear power plants in order to offer utilities appropriate solutions, Electricite de France and the Commissariat a l'Energie Atomique have jointly asked the Laboratoire de Psychologie du Travail to prepare an inventory of stress situations in nuclear electricity-generating centers. This document describes the approach used, the main concepts which have served as guidelines, and the methods of interpreting the results obtained through observations and questionnaires

  8. [Harm reduction interventions in drug users: current situation and recommendations].

    Science.gov (United States)

    Bosque-Prous, Marina; Brugal, María Teresa

    2016-11-01

    Harm reduction encompasses interventions, programmes and policies that seek to reduce the negative consequences of the consumption of both legal and illegal drugs on the individual and public health. Harm reduction looks to mitigate the harm suffered by drug users through drug use monitoring and prevention, and promotes initiatives that respect and protect the human rights of this population. The harm reduction policies that have proven effective and efficient are: opioid substitution maintenance therapy (methadone); needle and syringe exchange programmes; supervised drug consumption rooms; and overdose prevention through peer-based naloxone distribution. In order to be effective, these policies must have comprehensive coverage and be implemented in areas where the target population is prevalent. Resident-based opposition to the implementation of these policies is known as the NIMBY (Not In My Back Yard) phenomenon, which is characterised by being against the implementation of new measures in a particular place, but does not question their usefulness. Given that any NIMBY phenomenon is a complex social, cultural and political phenomenon, it is important to conduct a thorough analysis of the situation prior to implementing any of these measures. Harm reduction policies must be extended to other substances such as alcohol and tobacco, as well as to other conditions beyond infectious/contagious diseases and overdose. Copyright © 2016 SESPAS. Publicado por Elsevier España, S.L.U. All rights reserved.

  9. Maneuver Analysis and Targeting Strategy for the Stardust Re-Entry Capsule

    Science.gov (United States)

    Helfrich, Cliff; Bhat, Ramachand S.; Kangas, Julie A.; Wilson, Roby S.; Wong, Mau C.; Potts, Christopher L.; Williams, Kenneth E.

    2006-01-01

    The Stardust Sample Return Capsule (SRC) returned to Earth on January 15, 2006 after seven years of collecting interstellar and comet particles over three heliocentric revolutions, as shown in Figure 1. The SRC was carried on board the Stardust spacecraft, as shown in Figure 2. Because the spacecraft was built with unbalanced thrusters, turns and attitude control maintenance resulted in undesirable delta-v being imparted to the trajectory. As a result, a carefully planned maneuver strategy was devised to accurately target the Stardust capsule to the Utah Test and Training Range (UTTR). This paper provides an overview of the Stardust spacecraft and mission and describes the maneuver strategy that was employed to achieve the stringent targeting requirements for landing in Utah. In addition, an overview of Stardust maneuver analysis tools and techniques will also be presented.

  10. Identification of Cell Surface Targets through Meta-analysis of Microarray Data

    Directory of Open Access Journals (Sweden)

    Henry Haeberle

    2012-07-01

    Full Text Available High-resolution image guidance for resection of residual tumor cells would enable more precise and complete excision for more effective treatment of cancers, such as medulloblastoma, the most common pediatric brain cancer. Numerous studies have shown that brain tumor patient outcomes correlate with the precision of resection. To enable guided resection with molecular specificity and cellular resolution, molecular probes that effectively delineate brain tumor boundaries are essential. Therefore, we developed a bioinformatics approach to analyze micro-array datasets for the identification of transcripts that encode candidate cell surface biomarkers that are highly enriched in medulloblastoma. The results identified 380 genes with greater than a two-fold increase in the expression in the medulloblastoma compared with that in the normal cerebellum. To enrich for targets with accessibility for extracellular molecular probes, we further refined this list by filtering it with gene ontology to identify genes with protein localization on, or within, the plasma membrane. To validate this meta-analysis, the top 10 candidates were evaluated with immunohistochemistry. We identified two targets, fibrillin 2 and EphA3, which specifically stain medulloblastoma. These results demonstrate a novel bioinformatics approach that successfully identified cell surface and extracellular candidate markers enriched in medulloblastoma versus adjacent cerebellum. These two proteins are high-value targets for the development of tumor-specific probes in medulloblastoma. This bioinformatics method has broad utility for the identification of accessible molecular targets in a variety of cancers and will enable probe development for guided resection.

  11. ANDREEA NICOLAESCU, The Situation of Employees in Cultural Institutions. A Comparative Analysis Between Romania and the Countries of the European Union

    OpenAIRE

    CRISTINA LEOVARIDIS

    2009-01-01

    This article starts with a presentation of the role played in society by culture in general and by the cultural industries, in particular, complemented by a detailed definition of the concept of cultural industry. The more extensive part of the work is dedicated to the analysis of data referring to the workforce in the cultural industries. The article takes into account indicators which reflect, on the one hand, the situation of the personnel in the cultural sector as a whole, and, on the oth...

  12. Opportunities for Environmental Crime: A Test of Situational Crime Prevention Theory

    NARCIS (Netherlands)

    Huisman, W.; van Erp, J.

    2013-01-01

    Recently, Situational Crime Prevention Theory (SCPT) has been proposed as an alternative to offender-based theories of white-collar crime. This paper uses the results of a cross-case analysis of 23 criminal investigations of environmental crime in the Netherlands to explore the fruitfulness of SCPT

  13. In-silico Metabolome Target Analysis Towards PanC-based Antimycobacterial Agent Discovery.

    Science.gov (United States)

    Khoshkholgh-Sima, Baharak; Sardari, Soroush; Izadi Mobarakeh, Jalal; Khavari-Nejad, Ramezan Ali

    2015-01-01

    Mycobacterium tuberculosis, the main cause of tuberculosis (TB), has still remained a global health crisis especially in developing countries. Tuberculosis treatment is a laborious and lengthy process with high risk of noncompliance, cytotoxicity adverse events and drug resistance in patient. Recently, there has been an alarming rise of drug resistant in TB. In this regard, it is an unmet need to develop novel antitubercular medicines that target new or more effective biochemical pathways to prevent drug resistant Mycobacterium. Integrated study of metabolic pathways through in-silico approach played a key role in antimycobacterial design process in this study. Our results suggest that pantothenate synthetase (PanC), anthranilate phosphoribosyl transferase (TrpD) and 3-isopropylmalate dehydratase (LeuD) might be appropriate drug targets. In the next step, in-silico ligand analysis was used for more detailed study of chemical tractability of targets. This was helpful to identify pantothenate synthetase (PanC, Rv3602c) as the best target for antimycobacterial design procedure. Virtual library screening on the best ligand of PanC was then performed for inhibitory ligand design. At the end, five chemical intermediates showed significant inhibition of Mycobacterium bovis with good selectivity indices (SI) ≥10 according to Tuberculosis Antimicrobial Acquisition & Coordinating Facility of US criteria for antimycobacterial screening programs.

  14. Genome-wide identification of the regulatory targets of a transcription factor using biochemical characterization and computational genomic analysis

    Directory of Open Access Journals (Sweden)

    Jolly Emmitt R

    2005-11-01

    Full Text Available Abstract Background A major challenge in computational genomics is the development of methodologies that allow accurate genome-wide prediction of the regulatory targets of a transcription factor. We present a method for target identification that combines experimental characterization of binding requirements with computational genomic analysis. Results Our method identified potential target genes of the transcription factor Ndt80, a key transcriptional regulator involved in yeast sporulation, using the combined information of binding affinity, positional distribution, and conservation of the binding sites across multiple species. We have also developed a mathematical approach to compute the false positive rate and the total number of targets in the genome based on the multiple selection criteria. Conclusion We have shown that combining biochemical characterization and computational genomic analysis leads to accurate identification of the genome-wide targets of a transcription factor. The method can be extended to other transcription factors and can complement other genomic approaches to transcriptional regulation.

  15. Situation Awareness with Systems of Systems

    NARCIS (Netherlands)

    Laar, P. van de; Tretmans, J.; Borth, M.

    2013-01-01

    This book discusses various aspects, challenges, and solutions for developing systems-of-systems for situation awareness, using applications in the domain of maritime safety and security. Topics include advanced, multi-objective visualization methods for situation awareness, stochastic outlier

  16. Impact of high-risk conjunctions on Active Debris Removal target selection

    OpenAIRE

    Lidtke, Aleksander A.; Lewis, Hugh G.; Armellin, Roberto

    2015-01-01

    All rights reserved.Space debris simulations show that if current space launches continue unchanged, spacecraft operations might become difficult in the congested space environment. It has been suggested that Active Debris Removal (ADR) might be necessary in order to prevent such a situation. Selection of objects to be targeted by ADR is considered important because removal of non-relevant objects will unnecessarily increase the cost of ADR. One of the factors to be used in this ADR target se...

  17. Learning Behavior Analysis of a Ubiquitous Situated Reflective Learning System with Application to Life Science and Technology Teaching

    Science.gov (United States)

    Hwang, Wu-Yuin; Chen, Hong-Ren; Chen, Nian-Shing; Lin, Li-Kai; Chen, Jin-Wen

    2018-01-01

    Education research has shown that reflective study can efficiently enhance learning, and the acquisition of knowledge and skills from real-life situations has become a focus of interest for scholars. The knowledge-learning model based on verbal instruction, used in traditional classrooms, does not make use of real-life situations that encourage…

  18. Zur wirtschaftlichen Situation georgischer Landwirtschaftsbetriebe

    OpenAIRE

    Schulze, Eberhard; Tillack, Peter; Mosashwili, Nodar

    2003-01-01

    Dieser Forschungsbericht beinhaltet die Ergebnisse einer Untersuchung von 200 Familienbetrieben im Osten Georgiens im Distrikt Sighnagi in der Kakheti-Region Ende 2001/Anfang 2002. Sie dienten dem Ziel, Erkenntnisse über die wirtschaftliche Situation georgischer Familienbetriebe sowie zum Teil der sozialen Situation in Bauernfamilien nach zehn Jahren Transformationsprozess in der Landwirtschaft zu gewinnen. Die Untersuchungen schlossen die Befragung der Betriebsleiter nach dem Alter, der Daue...

  19. ANDREEA NICOLAESCU, The Situation of Employees in Cultural Institutions. A Comparative Analysis Between Romania and the Countries of the European Union

    Directory of Open Access Journals (Sweden)

    CRISTINA LEOVARIDIS

    2009-03-01

    Full Text Available This article starts with a presentation of the role played in society by culture in general and by the cultural industries, in particular, complemented by a detailed definition of the concept of cultural industry. The more extensive part of the work is dedicated to the analysis of data referring to the workforce in the cultural industries. The article takes into account indicators which reflect, on the one hand, the situation of the personnel in the cultural sector as a whole, and, on the other hand, according to fields of activity. The approach based on fields of activity aims at outlining a comparative image between the countries of the EU countries, but also a more indepth analysis of the data available for Romania.

  20. Random Scenario Generation for a Multiple Target Tracking Environment Evaluation

    DEFF Research Database (Denmark)

    Hussain, Dil Muhammad Akbar

    2006-01-01

    , which were normally crossing targets, was to test the efficiency of the track splitting algorithm for different situations. However this approach only gives a measure of performance for a specific, possibly unrealistic, scenario and it was felt appropriate to develop procedures that would enable a more...... general performance assessment. Therefore, a random target motion scenario is adopted. Its implementation in particular for testing the track splitting algorithm using Kalman filters is used and a couple of tracking performance parameters are computed to investigate such random scenarios....

  1. Automating data analysis for two-dimensional gas chromatography/time-of-flight mass spectrometry non-targeted analysis of comparative samples.

    Science.gov (United States)

    Titaley, Ivan A; Ogba, O Maduka; Chibwe, Leah; Hoh, Eunha; Cheong, Paul H-Y; Simonich, Staci L Massey

    2018-03-16

    Non-targeted analysis of environmental samples, using comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry (GC × GC/ToF-MS), poses significant data analysis challenges due to the large number of possible analytes. Non-targeted data analysis of complex mixtures is prone to human bias and is laborious, particularly for comparative environmental samples such as contaminated soil pre- and post-bioremediation. To address this research bottleneck, we developed OCTpy, a Python™ script that acts as a data reduction filter to automate GC × GC/ToF-MS data analysis from LECO ® ChromaTOF ® software and facilitates selection of analytes of interest based on peak area comparison between comparative samples. We used data from polycyclic aromatic hydrocarbon (PAH) contaminated soil, pre- and post-bioremediation, to assess the effectiveness of OCTpy in facilitating the selection of analytes that have formed or degraded following treatment. Using datasets from the soil extracts pre- and post-bioremediation, OCTpy selected, on average, 18% of the initial suggested analytes generated by the LECO ® ChromaTOF ® software Statistical Compare feature. Based on this list, 63-100% of the candidate analytes identified by a highly trained individual were also selected by OCTpy. This process was accomplished in several minutes per sample, whereas manual data analysis took several hours per sample. OCTpy automates the analysis of complex mixtures of comparative samples, reduces the potential for human error during heavy data handling and decreases data analysis time by at least tenfold. Copyright © 2018 Elsevier B.V. All rights reserved.

  2. Shift in power during an interview situation: methodological reflections inspired by Foucault and Bourdieu.

    Science.gov (United States)

    Aléx, Lena; Hammarström, Anne

    2008-06-01

    This paper presents methodological reflections on power sharing and shifts of power in various interview situations. Narratives are said to be shaped by our attempts to position ourselves within social and cultural circumstances. In an interview situation, power can be seen as something that is created and that shifts between the interviewer and the interviewed. Reflexivity is involved when we as interviewers attempt to look at a situation or a concept from various perspectives. A modified form of discourse analysis inspired by subject positioning was used to reflect on power relations in four different interview situations. The analyses indicate that reflection on the power relations can lead to other forms of understanding of the interviewee. The main conclusion that can be drawn from this study is that power relations are created within an interview situation and therefore it is important to be aware of dominant perspectives. Researchers and nurses face the challenge of constantly raising their level of consciousness about power relationships, and discursive reflexivity is one way of doing this. Thus, reflexivity is an important part of the qualitative research process.

  3. Motor Anticipation Failure in Infants with Autism: A Retrospective Analysis of Feeding Situations

    Science.gov (United States)

    Brisson, Julie; Warreyn, Petra; Serres, Josette; Foussier, Stephane; Adrien-Louis, Jean

    2012-01-01

    Previous studies on autism have shown a lack of motor anticipation in children and adults with autism. As part of a programme of research into early detection of autism, we focussed on an everyday situation: spoon-feeding. We hypothesize that an anticipation deficit may be found very early on by observing whether the baby opens his or her mouth in…

  4. Women's primary care nursing in situations of gender violence

    Directory of Open Access Journals (Sweden)

    Fernanda Visentin

    2015-12-01

    Full Text Available Objective.Identify the actions conducted by primary health care nurses for women in situations of domestic violence. Methodology. Exploratory-descriptive study with a qualitative approach. Participants were 17 nurses who worked in the Basic Health Unit in a city in the interior of Rio Grande do Sul, Brazil. The data was collected through semi-structured interviews and the information processing was performed using the interview content analysis technique. Results. By acting in a context of the violence, the nurses describe some elements and strategies they use that allow recognition and action to combat violence, namely: acceptance and empathy, establishing a bond of trust between the professional and the woman, dialogue, and intent listening. The limitations mentioned by participants were: lack of professional training to address the situation, feeling of unpreparedness, lack of time for the workload, the professional's difficulty in recognizing and dealing with violence given its complexity, low efficiency of the service network, and the sense of professional impotence against the gravity and complexity involved in violence. Conclusion. The participants are not adequately prepared to care for women in situations of domestic violence. It is necessary that this issue be addressed in the training of nursing professionals.

  5. Environmental management as situated practice

    DEFF Research Database (Denmark)

    Lippert, Ingmar; Krause, Franz; Hartmann, Niklas Klaus

    2015-01-01

    We propose an analysis of environmental management (EM) as work and as practical activity. This approach enables empirical studies of the diverse ways in which professionals, scientists, NGO staffers, and activists achieve the partial manageability of specific “environments”. In this introduction......, we sketch the debates in Human Geography, Management Studies, and Science and Technology Studies to which this special issue contributes. We identify the limits of understanding EM though the framework of ecological modernisation, and show how political ecology and work-place studies provide...... to be assessed, or as simply the implementation of dominant projects and the materialisation of hegemonic discourse. Such a shift renders EM as always messy practices of engagement, critique and improvisation. We conclude that studying the distributed and situated managing agencies, actors and their practices...

  6. Management of agricultural aspects in nuclear and/or radiological emergency situations

    International Nuclear Information System (INIS)

    Griperay, Gerard

    1997-01-01

    In revealing the agricultural aspects of the nuclear and/or radiological emergency situations the paper stresses upon the shocking role which the Chernobyl nuclear accident had on the agricultural management in France. Merely, the misunderstand, unawareness and lack of information relative to production as well as contamination conditions led to damages of FF 150 millions to the detriment of French farmers. Reflexions upon and analysis of this case has led to several conclusions concerning the role of information, the situation of international standards, and the lack of knowledge in important practical issues related to radioisotope migration in plants and agricultural products. Among the future lines of action in this field there are discussed the issues of indemnity, post-accident planning, drilling and information. In conclusion the following points are highlighted: 1. Redefinition of the EU standards; 2. Updating the situation of food and agricultural production units located around basic nuclear facilities in order to dispose of the necessary statistics to make decisions in emergency situations; 3. In absence of a post-accident plan, a scheme of action should be elaborated able to be rapidly implemented by public authorities in order to protect the consumer and restrict the supply to local market and exportation only to warranted agricultural products

  7. Personality-situation transactions from adolescence to old age.

    Science.gov (United States)

    Wrzus, Cornelia; Wagner, Gert G; Riediger, Michaela

    2016-05-01

    People presumably choose and create their daily environments according to their personality. Prior research shows that, for example, more extraverted people engage more often in social situations, and more conscientious people engage more often in work-related activities compared with less extraverted or less conscientious people, respectively. The current study examined such personality-situation transactions in people's daily life. Based on the assumption that older people know themselves and their personality better than younger people, we investigated whether momentary and proximate personality-situation associations (i.e., changing from 1 type of situation into another) increase with older age. Three-hundred and 78 people aged 14 to 82 years described their Big Five traits and took part in a 3-week experience-sampling phase. Using mobile-phone based assessments in daily life, participants reported on average 55 times on their momentary situation. Multilevel modeling results showed that personality-situation associations varied with the age of participants. Some of the "established" personality-situation associations, such as for extraversion and time spent with friends or conscientiousness and time spent with work activities, were only observed in adolescence and young adulthood. In contrast, other personality-situation associations appeared only in late adulthood, such as for openness and time spent with friends. Yet most personality-situation associations did not vary significantly with people's age. In addition, personality traits predicted maintaining or entering personality-congruent situations. The latter results point to the active role of personality in shaping one's environment. The findings imply that some personality-situation transactions may be largely similarly across the life span. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  8. Ranking of microRNA target prediction scores by Pareto front analysis.

    Science.gov (United States)

    Sahoo, Sudhakar; Albrecht, Andreas A

    2010-12-01

    Over the past ten years, a variety of microRNA target prediction methods has been developed, and many of the methods are constantly improved and adapted to recent insights into miRNA-mRNA interactions. In a typical scenario, different methods return different rankings of putative targets, even if the ranking is reduced to selected mRNAs that are related to a specific disease or cell type. For the experimental validation it is then difficult to decide in which order to process the predicted miRNA-mRNA bindings, since each validation is a laborious task and therefore only a limited number of mRNAs can be analysed. We propose a new ranking scheme that combines ranked predictions from several methods and - unlike standard thresholding methods - utilises the concept of Pareto fronts as defined in multi-objective optimisation. In the present study, we attempt a proof of concept by applying the new ranking scheme to hsa-miR-21, hsa-miR-125b, and hsa-miR-373 and prediction scores supplied by PITA and RNAhybrid. The scores are interpreted as a two-objective optimisation problem, and the elements of the Pareto front are ranked by the STarMir score with a subsequent re-calculation of the Pareto front after removal of the top-ranked mRNA from the basic set of prediction scores. The method is evaluated on validated targets of the three miRNA, and the ranking is compared to scores from DIANA-microT and TargetScan. We observed that the new ranking method performs well and consistent, and the first validated targets are elements of Pareto fronts at a relatively early stage of the recurrent procedure, which encourages further research towards a higher-dimensional analysis of Pareto fronts. Copyright © 2010 Elsevier Ltd. All rights reserved.

  9. Spacio-temporal situation assessment for mobile robots

    DEFF Research Database (Denmark)

    Beck, Anders Billesø; Risager, Claus; Andersen, Nils Axel

    2011-01-01

    chains are used to model the situation states and sequence, where stream clustering is used for state matching and dealing with noise. In experiments using simulated and real data, we show that we are able to learn a situation sequence for a mobile robot passing through a narrow passage. After learning......In this paper, we present a framework for situation modeling and assessment for mobile robot applications. We consider situations as data patterns that characterize unique circumstances for the robot, and represented not only by the data but also its temporal and spacial sequence. Dynamic Markov...

  10. Improved target detection and bearing estimation utilizing fast orthogonal search for real-time spectral analysis

    International Nuclear Information System (INIS)

    Osman, Abdalla; El-Sheimy, Naser; Nourledin, Aboelamgd; Theriault, Jim; Campbell, Scott

    2009-01-01

    The problem of target detection and tracking in the ocean environment has attracted considerable attention due to its importance in military and civilian applications. Sonobuoys are one of the capable passive sonar systems used in underwater target detection. Target detection and bearing estimation are mainly obtained through spectral analysis of received signals. The frequency resolution introduced by current techniques is limited which affects the accuracy of target detection and bearing estimation at a relatively low signal-to-noise ratio (SNR). This research investigates the development of a bearing estimation method using fast orthogonal search (FOS) for enhanced spectral estimation. FOS is employed in this research in order to improve both target detection and bearing estimation in the case of low SNR inputs. The proposed methods were tested using simulated data developed for two different scenarios under different underwater environmental conditions. The results show that the proposed method is capable of enhancing the accuracy for target detection as well as bearing estimation especially in cases of a very low SNR

  11. Assessing physician leadership styles: application of the situational leadership model to transitions in patient acuity.

    Science.gov (United States)

    Skog, Alexander; Peyre, Sarah E; Pozner, Charles N; Thorndike, Mary; Hicks, Gloria; Dellaripa, Paul F

    2012-01-01

    The situational leadership model suggests that an effective leader adapts leadership style depending on the followers' level of competency. We assessed the applicability and reliability of the situational leadership model when observing residents in simulated hospital floor-based scenarios. Resident teams engaged in clinical simulated scenarios. Video recordings were divided into clips based on Emergency Severity Index v4 acuity scores. Situational leadership styles were identified in clips by two physicians. Interrater reliability was determined through descriptive statistical data analysis. There were 114 participants recorded in 20 sessions, and 109 clips were reviewed and scored. There was a high level of interrater reliability (weighted kappa r = .81) supporting situational leadership model's applicability to medical teams. A suggestive correlation was found between frequency of changes in leadership style and the ability to effectively lead a medical team. The situational leadership model represents a unique tool to assess medical leadership performance in the context of acuity changes.

  12. The Energy and Water Emergency Module; A containerized solution for meeting the energy and water needs in protracted displacement situations

    DEFF Research Database (Denmark)

    Nerini, Francesco Fuso; Valentini, Francesco; Modi, Anish

    2015-01-01

    The world has faced many natural and man-made disasters in the past few years, resulting in millions of people living in temporary camps across the globe. The energy and clean water needs of the relief operators in such emergency situations are primarily satisfied by diesel engine based generators...... and importing clean water to the site, in certain cases even for several years after the emergency. This approach results in problems such as low security of supply and high costs. Especially targeting the prolonged displacement situations, this paper presents an alternative solution – the Energy and Water...

  13. PROBLEMS AND PROSPECTS OF THE WORLD FOOD SITUATION

    OpenAIRE

    Gebremedhin, Tesfa G.

    2000-01-01

    Although world food and agricultural production, based on current trends, will be sufficient to meet demand in the decades ahead, the world still faces a serious food crisis, at least as perilous and life-threatening for millions of poor people as those of the past. To this end, the main objective of this paper is to illuminate the world food situation and to provide a critical analysis of the core causes of world food insecurity by identifying the various misconceptions surrounding our under...

  14. Exploring the “Situation” of Situational Willingness to Communicate: A Volunteer Youth Exchange Perspective1

    Directory of Open Access Journals (Sweden)

    Callie Mady

    2010-12-01

    Full Text Available Abstract This paper presents the perspectives of youth participating in the Society for Educational Visits and Exchanges in Canada's Volunteer Youth Experience (VYE as gathered by way of pre- and post-program questionnaires, observations, interviews, and journals. The pan-Canadian questionnaire results suggest that this short, bilingual volunteer experience enhances participant motivation to learn a second official language and to be part of the target community. Triangulated findings from observations, interviews and journals indicate that participants' willingness to communicate (WTC in the second language (MacIntyre, Dörnyei, Clément, & Noels, 1998 may have been influenced by situational factors inherent to the volunteer experience such as access to native speakers of the target language and opportunities for authentic community participation.

  15. Adolescents' sense-making of alcohol-related risks: The role of drinking situations and social settings.

    Science.gov (United States)

    Katainen, Anu; Lehto, Anna-Sofia; Maunu, Antti

    2015-09-01

    The article explores how young people understand the risks of alcohol use and how these understandings are associated with differing drinking situations and social settings. By taking account of situational factors, the aim is to demonstrate how young people have highly nuanced notions of drinking styles that suit different drinking situations and of associated risks. The data for the research were gathered in 18 group interviews with Finnish ninth graders aged 14-15 years. Short film clips portraying young people in different drinking situations were used as stimulus material for the interviews. Data analysis focussed on the risk factors related to the social situations illustrated in the film clips. The results show that young people's risk assessments are not based on alcohol itself, but the magnitude of risk is estimated in relation to the social setting of the drinking situation. What is relevant for young people is whether the social situation allows them to make choices with which they feel comfortable. At the opposite pole of problem drinking was social drinking for the purpose of having fun together with other people in such a way that one remains in control of the drinking situation. From a prevention point of view, a key implication is that awareness of the risks is closely associated with situational and social factors. However, the awareness of those risks does not necessarily prevent young people from drinking because they may be accepted as part of the drinking experience. © The Author(s) 2014.

  16. Auger radiation targeted into DNA: a therapy perspective

    Energy Technology Data Exchange (ETDEWEB)

    Buchegger, Franz [University Hospital of Lausanne CHUV, Service of Nuclear Medicine, Lausanne (Switzerland); University Hospital of Lausanne, Service of Nuclear Medicine, Lausanne (Switzerland); Perillo-Adamer, Florence; Bischof Delaloye, Angelika [University Hospital of Lausanne CHUV, Service of Nuclear Medicine, Lausanne (Switzerland); Dupertuis, Yves M. [University Hospital of Geneva, Service of Nutrition, Geneva (Switzerland)

    2006-11-15

    Auger electron emitters that can be targeted into DNA of tumour cells represent an attractive systemic radiation therapy goal. In the situation of DNA-associated decay, the high linear energy transfer (LET) of Auger electrons gives a high relative biological efficacy similar to that of {alpha} particles. In contrast to {alpha} radiation, however, Auger radiation is of low toxicity when decaying outside the cell nucleus, as in cytoplasm or outside cells during blood transport. The challenge for such therapies is the requirement to target a high percentage of all cancer cells. An overview of Auger radiation therapy approaches of the past decade shows several research directions and various targeting vehicles. The latter include hormones, peptides, halogenated nucleotides, oligonucleotides and internalising antibodies. Here, we will discuss the basic principles of Auger electron therapy as compared with vector-guided {alpha} and {beta} radiation. We also review some radioprotection issues and briefly present the main advantages and disadvantages of the different targeting modalities that are under investigation. (orig.)

  17. Auger radiation targeted into DNA: a therapy perspective

    International Nuclear Information System (INIS)

    Buchegger, Franz; Perillo-Adamer, Florence; Bischof Delaloye, Angelika; Dupertuis, Yves M.

    2006-01-01

    Auger electron emitters that can be targeted into DNA of tumour cells represent an attractive systemic radiation therapy goal. In the situation of DNA-associated decay, the high linear energy transfer (LET) of Auger electrons gives a high relative biological efficacy similar to that of α particles. In contrast to α radiation, however, Auger radiation is of low toxicity when decaying outside the cell nucleus, as in cytoplasm or outside cells during blood transport. The challenge for such therapies is the requirement to target a high percentage of all cancer cells. An overview of Auger radiation therapy approaches of the past decade shows several research directions and various targeting vehicles. The latter include hormones, peptides, halogenated nucleotides, oligonucleotides and internalising antibodies. Here, we will discuss the basic principles of Auger electron therapy as compared with vector-guided α and β radiation. We also review some radioprotection issues and briefly present the main advantages and disadvantages of the different targeting modalities that are under investigation. (orig.)

  18. Position finding 1993 - comments on the situation of mining in Germany

    International Nuclear Information System (INIS)

    Leuschner, H.J.

    1993-01-01

    The lecture delivered on the meeting of the Bavarian mining industry in Bad Reichenhall on October 15, 1993, is centered on the report on the actual situation of the individual branches of mining in Germany. This analysis of the situation of mining is to be seen in front of the background of the present discussion on the prospects of Germany as place of investments. The key question was raised viz. the question of the future of mining and the mining suppliers. The main conclusion reads: The mining industries need a clearly defined framework of conditions decided upon on political level and reliable enough for being a sound basis for long-term investment decisions. (orig.)

  19. In vivo potency revisited - Keep the target in sight.

    Science.gov (United States)

    Gabrielsson, Johan; Peletier, Lambertus A; Hjorth, Stephan

    2018-04-01

    Potency is a central parameter in pharmacological and biochemical sciences, as well as in drug discovery and development endeavors. It is however typically defined in terms only of ligand to target binding affinity also in in vivo experimentation, thus in a manner analogous to in in vitro studies. As in vivo potency is in fact a conglomerate of events involving ligand, target, and target-ligand complex processes, overlooking some of the fundamental differences between in vivo and in vitro may result in serious mispredictions of in vivo efficacious dose and exposure. The analysis presented in this paper compares potency measures derived from three model situations. Model A represents the closed in vitro system, defining target binding of a ligand when total target and ligand concentrations remain static and constant. Model B describes an open in vivo system with ligand input and clearance (Cl (L) ), adding in parallel to the turnover (k syn , k deg ) of the target. Model C further adds to the open in vivo system in Model B also the elimination of the target-ligand complex (k e(RL) ) via a first-order process. We formulate corresponding equations of the equilibrium (steady-state) relationships between target and ligand, and complex and ligand for each of the three model systems and graphically illustrate the resulting simulations. These equilibrium relationships demonstrate the relative impact of target and target-ligand complex turnover, and are easier to interpret than the more commonly used ligand-, target- and complex concentration-time courses. A new potency expression, labeled L 50 , is then derived. L 50 is the ligand concentration at half-maximal target and complex concentrations and is an amalgamation of target turnover, target-ligand binding and complex elimination parameters estimated from concentration-time data. L 50 is then compared to the dissociation constant K d (target-ligand binding affinity), the conventional Black & Leff potency estimate EC 50

  20. Distributions of hit-numbers in single targets

    Energy Technology Data Exchange (ETDEWEB)

    Fowler, J F [Postgraduate Medical School, Hammersmith Hospital, London (United Kingdom)

    1966-07-01

    Very general models can be proposed for relating the surviving proportion of an irradiated population of cells or bacteria to the absorbed dose, but if the number of free parameters is large the model can never be tested experimentally (Zimmer; Zirkie; Tobias). A relatively simple model is therefore proposed here, based on the physical facts of energy deposition in small volumes which are currently under active investigation (Rossi), and on cell-survival experiments over a wide range of LET (e.g. Barendsen et al.; Barendsen). It is not suggested that the model is correct or final, but only that its shortcomings should be demonstrated by comparison with experimental results before more complicated models are worth pursuing. It is basically a multihit model applied first to a single target volume, but also applicable to the situation where only one out of many potential target volumes has to be inactivated to kill the organism. It can be extended to two or more target volumes if necessary. Emphasis is placed upon the amount of energy locally deposited in certain sensitive volumes called 'target volumes'.

  1. Protein targeting in the analysis of learning and memory: a potential alternative to gene targeting.

    Science.gov (United States)

    Gerlai, R; Williams, S P; Cairns, B; Van Bruggen, N; Moran, P; Shih, A; Caras, I; Sauer, H; Phillips, H S; Winslow, J W

    1998-11-01

    Gene targeting using homologous recombination in embryonic stem (ES) cells offers unprecedented precision with which one may manipulate single genes and investigate the in vivo effects of defined mutations in the mouse. Geneticists argue that this technique abrogates the lack of highly specific pharmacological tools in the study of brain function and behavior. However, by now it has become clear that gene targeting has some limitations too. One problem is spatial and temporal specificity of the generated mutation, which may appear in multiple brain regions or even in other organs and may also be present throughout development, giving rise to complex, secondary phenotypical alterations. This may be a disadvantage in the functional analysis of a number of genes associated with learning and memory processes. For example, several proteins, including neurotrophins--cell-adhesion molecules--and protein kinases, that play a significant developmental role have recently been suggested to be also involved in neural and behavioral plasticity. Knocking out genes of such proteins may lead to developmental alterations or even embryonic lethality in the mouse, making it difficult to study their function in neural plasticity, learning, and memory. Therefore, alternative strategies to gene targeting may be needed. Here, we suggest a potentially useful in vivo strategy based on systemic application of immunoadhesins, genetically engineered fusion proteins possessing the Fc portion of the human IgG molecule and, for example, a binding domain of a receptor of interest. These proteins are stable in vivo and exhibit high binding specificity and affinity for the endogenous ligand of the receptor, but lack the ability to signal. Thus, if delivered to the brain, immunoadhesins may specifically block signalling of the receptor of interest. Using osmotic minipumps, the protein can be infused in a localized region of the brain for a specified period of time (days or weeks). Thus, the location

  2. Non-specific chronic orofacial pain patients' experiences of everyday life situations: a qualitative study.

    Science.gov (United States)

    Wolf, Eva; Nilner, Maria; Petersson, Kerstin

    2016-01-01

    Chronic orofacial pain is a complex condition with consequences that affect daily living. The aim was to analyse nonspecific chronic orofacial pain patients'experiences of everyday life situations, using a qualitative approach. Eleven women and 3 men (21 to 77years) were selected through a purposive sampling among chronic orofacial pain patients referred to the Faculty of Odontology's orofacial pain unit at Malmö University, Malmö Sweden. All selected subjects agreed to participate. Data were obtained via two thematic in-depth interviews with each subject. Interviews were taped and transcribed verbatim.Text dealing with the subjects' daily experiences was identified in all interviews and analysed using qualitative content analysis that focused on manifest content. In everyday life situations, the analysis of nonspecific chronic orofacial pain patients' narrations exposed a fear of conflict, of personal weakness, and of the intangible; they also exposed self-blame and avoidance of fear-triggering situations. Eight of the 14 subjects did not spontaneously mention any situation in which they were content during daily living. When the patients spoke about everyday life experiences, the main finding was that unpleasant emotions dominated the subjects'experiences. In conclusion, the chronic orofacial pain condition cannot be understood as an isolated phenomenon; it must be considered in rela- tion to the person who is suffering from the condition.

  3. Situational analysis of facilitators and barriers to availability and utilization of magnesium sulfate for eclampsia and severe preeclampsia in the public health system in Brazil.

    Science.gov (United States)

    Lotufo, Fátima Aparecida; Parpinelli, Mary Angela; Osis, Maria José; Surita, Fernanda Garanhani; Costa, Maria Laura; Cecatti, José Guilherme

    2016-08-30

    Eclampsia is the main cause of maternal death in Brazil. Magnesium sulfate is the drug of choice for seizure prevention and control in the management of severe preeclampsia and eclampsia. Despite scientific evidence demonstrating its effectiveness and safety, there have been delays in managing hypertensive disorders, including timely access to magnesium sulfate. To conduct a general situational analysis on availability and use of magnesium sulfate for severe preeclampsia and eclampsia in the public health system. A situational analysis was conducted with two components: a documental analysis on information available at the official websites on the policy, regulation and availability of the medication, plus a cross sectional study with field analysis and interviews with local managers of public obstetric health services in Campinas, in the southeast of Brazil. We used the fishbone cause and effect diagram to organize study components. Interviews with managers were held during field observations using specific questionnaires. There was no access to magnesium sulfate in primary care facilities, obstetric care was excluded from urgency services and clinical protocols for professional guidance on the adequate use of magnesium sulfate were lacking in the emergency mobile care service. Magnesium sulfate is currently only administered in referral maternity hospitals. The lack of processes that promote the integration between urgency/emergency care and specialized obstetric care possibly favors the untimely use of magnesium sulfate and contributes to the high maternal morbidity/mortality rates.

  4. A Brief Analysis of Development Situations and Trend of Cloud Computing

    Science.gov (United States)

    Yang, Wenyan

    2017-12-01

    in recent years, the rapid development of Internet technology has radically changed people's work, learning and lifestyles. More and more activities are completed by virtue of computers and networks. The amount of information and data generated is bigger day by day, and people rely more on computer, which makes computing power of computer fail to meet demands of accuracy and rapidity from people. The cloud computing technology has experienced fast development, which is widely applied in the computer industry as a result of advantages of high precision, fast computing and easy usage. Moreover, it has become a focus in information research at present. In this paper, the development situations and trend of cloud computing shall be analyzed and researched.

  5. Seeking Health Information Online: The Moderating Effects of Problematic Situations on User Intention

    Directory of Open Access Journals (Sweden)

    Lidan Xia

    2017-03-01

    Full Text Available Purpose: This study investigates how online user intention in searching health information is affected by problematic situations. Design/methodology/approach: Based on the Theory of Reasoned Action, the Technology Acceptance Model, and Sense-making theory, we propose two dimensions of problematic situations: urgency and severity of health issues being searched online. Data were collected through a questionnaire survey among 214 Wuhan University students and analyzed using hierarchical regression analysis. Findings: Perceived usefulness, perceived ease of use, and subjective norm can influence user intention to seek health information online. The urgency of problematic situations has a negative moderating effect on the relationship between perceived ease of use and user intention and the relationship between subjective norm and user intention. The severity of problematic situations has a negative moderating effect on the relationship between subjective norm and user intention. Research limitations: The respondents of the survey are limited to students in one Chinese university, so whether this study’s results can be applied to another population or not remains to be verified. In addition, only two dimensions of problematic situations are considered in this study. Practical implications: The paper puts forward the moderating effect of problematic situations and verifies it, which is the compensation for online health information-seeking behavior research. Besides, our analyses have implications for professional design of health care systems and related consumer information searches, and improve their performance. Originality/value: Previous work has reported the effects of problematic situation on user intention to seek health information online, ignoring its influence on other factors. This empirical study extends that work to identify the influence of problematic situation when seeking intention-behavior data in two dimensions, urgency and

  6. Modeling of Communication in a Computational Situation Assessment Model

    International Nuclear Information System (INIS)

    Lee, Hyun Chul; Seong, Poong Hyun

    2009-01-01

    Operators in nuclear power plants have to acquire information from human system interfaces (HSIs) and the environment in order to create, update, and confirm their understanding of a plant state, or situation awareness, because failures of situation assessment may result in wrong decisions for process control and finally errors of commission in nuclear power plants. Quantitative or prescriptive models to predict operator's situation assessment in a situation, the results of situation assessment, provide many benefits such as HSI design solutions, human performance data, and human reliability. Unfortunately, a few computational situation assessment models for NPP operators have been proposed and those insufficiently embed human cognitive characteristics. Thus we proposed a new computational situation assessment model of nuclear power plant operators. The proposed model incorporating significant cognitive factors uses a Bayesian belief network (BBN) as model architecture. It is believed that communication between nuclear power plant operators affects operators' situation assessment and its result, situation awareness. We tried to verify that the proposed model represent the effects of communication on situation assessment. As the result, the proposed model succeeded in representing the operators' behavior and this paper shows the details

  7. The today situation and the nuclear sector perspectives in Usa; La situation actuelle et les perspectives du secteur nucleaire aux Etats-Unis

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    In this analysis the author details and discusses the nuclear energy situation in the Usa: the park and the electric power production, the nuclear safety and the radiation protection, the licenses prolongation, the power increase, the regulation relative to the construction of new reactors, the combined construction permit and operating license, the uncertainties on the Yucca Mountain storage site and the Global Nuclear Energy Partnership initiative, the 2006 perspectives and the IV generation reactors. (A.L.B.)

  8. Creativity as openness: improvising health and care 'situations'.

    Science.gov (United States)

    Oliver, James

    2009-12-01

    Creativity has become an oft-used word in UK public policy, but perhaps it is also under-imagined. This paper contends that there is an instrumental tendency to narrowly frame creativity as innovation, implying a reproducible product, instead of more openly as improvisation, a situational, embodied and temporal process. This is not a simple dichotomy (innovation and improvisation, product and process, can be mutually informing concepts), nor is it specifically a question of definition; rather, it relates to an ontological orientation, and related to that are issues of epistemological implications. In particular the paper is concerned with the value of the arts in public policy, as situated in the social, and therefore human, spaces of health and care; and more generally the arts in society. The paper brings together a broad discussion from across disciplines, not in an interdisciplinary attempt to solve a problem, or to be reductive in the analysis, but to begin to approach a reorienting of understandings of creativity and the human value and foundation of the arts in society.

  9. A foundational observation method for studying design situations

    DEFF Research Database (Denmark)

    Cash, Philip; Hicks, Ben; Culley, Steve

    2015-01-01

    Observational studies of designers play an important role in engineering design research, yet there is currently no accepted standard approach for comparing, combining, or contrasting studies. Consequentially, reuse, reanalysis, replication, and aggregation of data are limited and the potential...... that covers capture, coding, and analysis. The capture step defines overall and situational context as well as multiple capture streams, generating a broad data-set that can be examined from multiple perspectives. The coding step employs a multi-level approach that seeks to minimise workload while describing...

  10. 14 CFR 99.5 - Emergency situations.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Emergency situations. 99.5 Section 99.5 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES SECURITY CONTROL OF AIR TRAFFIC General § 99.5 Emergency situations. In an...

  11. Situational Factors in Focus Group Studies: A Systematic Review

    OpenAIRE

    Arne Orvik MPolSc; Lillebeth Larun PhD; Astrid Berland MSc; Karin C. Ringsberg PhD

    2013-01-01

    The aim of this study was to see how contextual factors are expressed, used, and analyzed in data collected in focus group discussions (FGDs). The study includes an assessment of how the methodological reporting of contextual factors might influence and improve the trustworthiness of articles. Articles reporting workplace health, stress, and coping among health professionals were identified in a systematic review and used in the analysis. By using Vicsek's framework of situational factors for...

  12. Sejong Open Cluster Survey (SOS). 0. Target Selection and Data Analysis

    Science.gov (United States)

    Sung, Hwankyung; Lim, Beomdu; Bessell, Michael S.; Kim, Jinyoung S.; Hur, Hyeonoh; Chun, Moo-Young; Park, Byeong-Gon

    2013-06-01

    Star clusters are superb astrophysical laboratories containing cospatial and coeval samples of stars with similar chemical composition. We initiate the Sejong Open cluster Survey (SOS) - a project dedicated to providing homogeneous photometry of a large number of open clusters in the SAAO Johnson-Cousins' UBVI system. To achieve our main goal, we pay much attention to the observation of standard stars in order to reproduce the SAAO standard system. Many of our targets are relatively small sparse clusters that escaped previous observations. As clusters are considered building blocks of the Galactic disk, their physical properties such as the initial mass function, the pattern of mass segregation, etc. give valuable information on the formation and evolution of the Galactic disk. The spatial distribution of young open clusters will be used to revise the local spiral arm structure of the Galaxy. In addition, the homogeneous data can also be used to test stellar evolutionary theory, especially concerning rare massive stars. In this paper we present the target selection criteria, the observational strategy for accurate photometry, and the adopted calibrations for data analysis such as color-color relations, zero-age main sequence relations, Sp - M_V relations, Sp - T_{eff} relations, Sp - color relations, and T_{eff} - BC relations. Finally we provide some data analysis such as the determination of the reddening law, the membership selection criteria, and distance determination.

  13. Understanding Child Sexual Abuse by Catholic Priests from a Situational Perspective

    Science.gov (United States)

    Terry, Karen J.; Freilich, Joshua D.

    2012-01-01

    Most sexual offense research focuses on offender motivation and individual risk factors rather than the criminal events themselves. This article provides an analysis of data from two studies on child sexual abuse by Catholic priests to help understand the opportunities clergy had or created to abuse youth. Findings show that situational factors…

  14. Enhanced situational technologies applied to ship channels

    Science.gov (United States)

    Helgeson, Michael A.; Wacker, Roger A.

    1997-06-01

    The Houston Ship Channel ranks as America's number one port in foreign tonnage by welcoming more than 50,000 cargo ships and barges annually. Locally 196,000 jobs, 5.5 billion dollars in business revenue and 213 million dollars in taxes are generated. Unfortunately, 32 days of each year vessel traffic stops for hours due to fog causing an estimated 40- 100 million dollars loss as ships idly wait in the channel for weather to clear. In addition, poor visibility has contributed to past vessel collisions which have resulted in channel closure, and associated damage to property and the environment. Today's imaging technology for synthetic vision systems and enhanced situational awareness systems offers a new solution to this problem. Whereas, typically these systems have been targeted at aircraft landing systems the channel navigation application provides a peripheral ground based market. This paper describes two imaging solutions to the problem. One using an active 35 GHz scanning radar and the other using a 94 GHz passive millimeter wave camera.

  15. 2. interim report on radiation situation in Finland from 5 to 16 May 1986

    International Nuclear Information System (INIS)

    1986-05-01

    This second interim report is a continuation of the first 'Fallout situation in Finland from April 26 to May 4' STUK-B-VALO-44. It deals with the results from external radiation measurements and analysis of environmental and foodstuff samples between 5 and 16 May, i.e. the development of the situation after the fallout peak. The whole-body counter measurements of tourists returning from the Soviet Union and from other countries in Eastern Europe after the accident are also reported

  16. Prosocial attitudes and empathic behavior in emotional positive versus negative situations: brain response (ERPs) and source localization (LORETA) analysis.

    Science.gov (United States)

    Balconi, Michela; Canavesio, Ylenia

    2013-03-01

    The present research firstly investigated the neural correlates (ERPs, event-related potentials) of attitudes to engage in prosocial-helping behaviors, and secondly, it analyzed the relation between these brain-based potentials and personal profile (high vs. low empathic profile). It was considered the subjects' behavior in response to specific emotional situations (positive vs. negative) in case it was required a possible prosocial intervention. Thirty-one subjects were invited to empathize with the emotional contexts (videotapes that reproduced two person's exchanges) and to decide whether to intervene or not to support these persons. BEES questionnaire for empathic behavior was submitted to the subjects after the experimental session. ERP acquisition and LORETA source analysis revealed a negative ongoing deflection (N200 effect) more prefrontally distributed (dorsolateral prefrontal cortex) in response to prosocial intervention options mainly for negative and positive contexts. Moreover, a significant positive correlation was found between high-empathic profiles, intervention behaviors (higher frequency of interventions) and N200 amplitude (higher peak). These results highlight the role of emotions in prosocial behavior, since the N200 effect was considered a marker of the emotional significance of the interpersonal situation. Secondly, the empathic trait may explain the prosocial decisional processes: Higher empathic trait contributes to induce subject's intervention behavior which in turn appears to be directly related to the cortical responsiveness within the prefrontal areas.

  17. Demographic and health situation of children in conditions of economic destabilization in the Ukraine.

    Science.gov (United States)

    Pantyley, Viktoriya

    2014-01-01

    In new conditions of socio-economic development in the Ukraine, the health of the population of children is considered as the most reliable indicator of socio-economic development of the country. The primary goal of the study was analysis of the effect of contemporary socio-economic transformations, their scope, and strength of effect on the demographic and social situation of children in various regions of the Ukraine. The methodological objectives of the study were as follows: development of a synthetic measure of the state of health of the population of children, based on the Hellwig's method, and selection of districts in the Ukraine according to the present health-demographic situation of children. The study was based on statistical data from the State Statistics Service of Ukraine, Centre of Medical Statistics in Kiev, Ukrainian Ministry of Defence, as well as Ministry of Education and Science, Youth and Sports of Ukraine. The following research methods were used: analysis of literature and Internet sources, selection and analysis of statistical materials, cartographic and statistical methods. Basic indices of the demographic and health situation of the population of children were analyzed, as well as factors of a socio-economic nature which affect this situation. A set of variables was developed for the synthetic evaluation of the state of health of the population of children. The typology of the Ukrainian districts was performed according to the state of health of the child population, based on the Hellwig's taxonomic method. Deterioration was observed of selected quality parameters, as well as a change in the strength and directions of effect of factors of organizational-institutional, socioeconomic, historical and cultural nature on the population of children potential.

  18. An exploration of the applicability of situational segmentation in the health care market: development of a situational taxonomy.

    Science.gov (United States)

    Gehrt, K C; Pinto, M B

    1990-01-01

    Competition in the health care market has intensified in recent years. Health care providers are increasingly adopting innovative marketing techniques to secure their positions in the marketplace. This paper examines an innovative marketing technique, situational segmentation, and assesses its applicability to the health care market. Situational segmentation has proven useful in many consumer goods markets but has received little attention in the context of health care marketing. A two-stage research process is used to develop a taxonomy of situational factors pertinent to health care choice. In stage one, focus group interviews are used to gather information which is instrumental to questionnaire development. In stage two, the responses of 151 subjects to a 51 item questionnaire are factor analyzed. The results demonstrate that situational segmentation is a viable strategy in the health care market.

  19. The Didactic Engineering for the Math Olympics Teaching: Olympic Situations with Geogebra’s Support

    Directory of Open Access Journals (Sweden)

    Ana Paula Rodrigues Alves Santos

    2018-01-01

    Full Text Available In this article, we intend to present a partial cut of a master's research, in which we describe, in a specific way, two phases determined by Didactic Engineering - ED in the context of the Mathematical Olympiads. Thus, we have the stages of preliminary analyzes and the construction of Olympic situations/a priori analysis. We emphasize in an Olympic situation that is described/structured with the support of GeoGebra software. Intervention through the proper exploitation of software provides the learner with opportunities to overcome certain difficulties/obstacles to an understanding or even conceptual construction in geometry. In this sense, the mentioned Olympic situation was experienced by students of the ninth year of elementary education II, from a private school in the state of Ceara, Brazil. The Olympic situation described proposes the possibility of the construction of metric relations in the triangle rectangle, content referring to the area of plane geometry. The ED is presented in this research, as a vision of complementarity that uses the theory of didactic situations - TSD. In this way, the described Olympic situation represents an alternative to classes directed to the math Olympics, their indication and structure, describes elements related to didactic mediation during the teaching and learning process, which emphasize details that make it possible to control and predict the possible student’s actions, as well as, to provide the experience of more significant didactic situations for geometry study in the Olympic context.

  20. [Exploration on Electroencephalogram Mechanism Differences of Negative Emotions Induced by Disgusted and Sad Situation Images].

    Science.gov (United States)

    Wang, Xin; Jin, Jingna; Li, Song; Liu, Zhipeng; Yin, Tao

    2015-12-01

    Evolutionary psychology holds such an opinion that negative situation may threaten survival, trigger avoidance motive and have poor effects on the human-body function and the psychological quality. Both disgusted and sad situations can induce negative emotions. However, differences between the two situations on attention capture and emotion cognition during the emotion induction are still not well known. Typical disgusted and sad situation images were used in the present study to induce two negative emotions, and 15 young students (7 males and 8 females, aged 27 ± 3) were recruited in the experiments. Electroencephalogram of 32 leads was recorded when the subjects were viewing situation images, and event-related potentials (ERP) of all leads were obtained for future analysis. Paired sample t tests were carried out on two ERP signals separately induced by disgusted and sad situation images to get time quantum with significant statistical differences between the two ERP signals. Root-mean-square deviations of two ERP signals during each time quantum were calculated and the brain topographic map based on root-mean-square deviations was drawn to display differences of two ERP signals in spatial. Results showed that differences of ERP signals induced by disgusted and sad situation images were mainly manifested in T1 (120-450 ms) early and T2 (800-1,000 ms) later. During the period of T1, the occipital lobe reflecting attention capture was activated by both disgusted and sad situation images, but the prefrontal cortex reflecting emotion sense was activated only by disgusted situation images. During the period of T2, the prefrontal cortex was activated by both disgusted and sad situation images. However, the parietal lobe was activated only by disgusted situation images, which showed stronger emotional perception. The research results would have enlightenment to deepen understanding of negative emotion and to exploredeep cognitive neuroscience mechanisms of negative

  1. [Support psychotherapy in traumatic situations].

    Science.gov (United States)

    Pérez-Sales, Pau; Vázquez Valverde, Carmelo

    2003-12-01

    It seems that a certain consensus exists to speak about a traumatic situation as an experience which is made up of a threat on the physical or psychological integrity of a person and against which one responds with fear, desperation and intensive horror. Different psychological phenomena are involved with the manner through which a human being confronts his/her past. In particular, the response to traumatic situations, mourning, and blame share their characteristic of being an irreversible living reality related to facts, loss or past impacts and it is necessary to integrate these in one's life in order to advance; these comprise a triangle frequently coexisting and interconnected. Aid for these three situations has, therefore, as common elements, two premises: an active task is required by the person who suffers this situation; this person must, in some form, desire to move ahead. One can not toil in mourning, in a traumatic experience, or in a life of blame if these have a positive symbolic value for this person; for example, mourning as a manner not to treason the dead person by forgetting that person, the reliving a trauma as an attempt to provide some sense to the actions which occurred, or blame as a desire to not forget an error or as a final punishment of this active task; the final objective of this active task is not usually to forget but to integrate in order to live. If a person does not perceive this clearly, this person may not become actively involved in the task to overcome a traumatic situation and to move ahead, nor will that person accept that a person who tries to help questions this person's realities or experiences.

  2. Whole genome analysis of CRISPR Cas9 sgRNA off-target homologies via an efficient computational algorithm.

    Science.gov (United States)

    Zhou, Hong; Zhou, Michael; Li, Daisy; Manthey, Joseph; Lioutikova, Ekaterina; Wang, Hong; Zeng, Xiao

    2017-11-17

    The beauty and power of the genome editing mechanism, CRISPR Cas9 endonuclease system, lies in the fact that it is RNA-programmable such that Cas9 can be guided to any genomic loci complementary to a 20-nt RNA, single guide RNA (sgRNA), to cleave double stranded DNA, allowing the introduction of wanted mutations. Unfortunately, it has been reported repeatedly that the sgRNA can also guide Cas9 to off-target sites where the DNA sequence is homologous to sgRNA. Using human genome and Streptococcus pyogenes Cas9 (SpCas9) as an example, this article mathematically analyzed the probabilities of off-target homologies of sgRNAs and discovered that for large genome size such as human genome, potential off-target homologies are inevitable for sgRNA selection. A highly efficient computationl algorithm was developed for whole genome sgRNA design and off-target homology searches. By means of a dynamically constructed sequence-indexed database and a simplified sequence alignment method, this algorithm achieves very high efficiency while guaranteeing the identification of all existing potential off-target homologies. Via this algorithm, 1,876,775 sgRNAs were designed for the 19,153 human mRNA genes and only two sgRNAs were found to be free of off-target homology. By means of the novel and efficient sgRNA homology search algorithm introduced in this article, genome wide sgRNA design and off-target analysis were conducted and the results confirmed the mathematical analysis that for a sgRNA sequence, it is almost impossible to escape potential off-target homologies. Future innovations on the CRISPR Cas9 gene editing technology need to focus on how to eliminate the Cas9 off-target activity.

  3. PRICE-LEVEL TARGETING – A VIABLE ALTERNATIVE TO INFLATION TARGETING?

    OpenAIRE

    Iulian Vasile Popescu

    2012-01-01

    The recent financial crisis that has led some central banks reaching the zero lower bound of their interest rate to use unconventional monetary policy instruments, has brought to the forefront the academic discussions on the shift from inflation targeting (IT) to price level targeting. This paper provides a comparative analysis on IT strategy and targeting the price level, assesses the implications and highlights the challenges of an eventual transition to a new monetary policy strategy. Bala...

  4. Exploring schema-driven differences in situation awareness between road users: an on-road study of driver, cyclist and motorcyclist situation awareness.

    Science.gov (United States)

    Salmon, Paul M; Lenne, Michael G; Walker, Guy H; Stanton, Neville A; Filtness, Ashleigh

    2014-01-01

    Collisions between different road users make a substantial contribution to road trauma. Although evidence suggests that different road users interpret the same road situations differently, it is not clear how road users' situation awareness differs, nor is it clear which differences might lead to conflicts. This article presents the findings from an on-road study conducted to examine driver, motorcyclist and cyclist situation awareness in different road environments. The findings suggest that, in addition to minor differences in the structure of different road users' situation awareness (i.e. amount of information and how it is integrated), the actual content of situation awareness in terms of road user schemata, the resulting interaction with the world and the information underpinning situation awareness is markedly different. Further examination indicates that the differences are likely to be compatible along arterial roads, shopping strips and at roundabouts, but that they may create conflicts between different road users at intersections. Interventions designed to support compatible situation awareness and behaviour between different road users are discussed.

  5. Microarray Gene Expression Analysis to Evaluate Cell Type Specific Expression of Targets Relevant for Immunotherapy of Hematological Malignancies.

    Directory of Open Access Journals (Sweden)

    M J Pont

    Full Text Available Cellular immunotherapy has proven to be effective in the treatment of hematological cancers by donor lymphocyte infusion after allogeneic hematopoietic stem cell transplantation and more recently by targeted therapy with chimeric antigen or T-cell receptor-engineered T cells. However, dependent on the tissue distribution of the antigens that are targeted, anti-tumor responses can be accompanied by undesired side effects. Therefore, detailed tissue distribution analysis is essential to estimate potential efficacy and toxicity of candidate targets for immunotherapy of hematological malignancies. We performed microarray gene expression analysis of hematological malignancies of different origins, healthy hematopoietic cells and various non-hematopoietic cell types from organs that are often targeted in detrimental immune responses after allogeneic stem cell transplantation leading to graft-versus-host disease. Non-hematopoietic cells were also cultured in the presence of IFN-γ to analyze gene expression under inflammatory circumstances. Gene expression was investigated by Illumina HT12.0 microarrays and quality control analysis was performed to confirm the cell-type origin and exclude contamination of non-hematopoietic cell samples with peripheral blood cells. Microarray data were validated by quantitative RT-PCR showing strong correlations between both platforms. Detailed gene expression profiles were generated for various minor histocompatibility antigens and B-cell surface antigens to illustrate the value of the microarray dataset to estimate efficacy and toxicity of candidate targets for immunotherapy. In conclusion, our microarray database provides a relevant platform to analyze and select candidate antigens with hematopoietic (lineage-restricted expression as potential targets for immunotherapy of hematological cancers.

  6. An investigative approach to explore optimum assembly process design for annular targets carrying LEU foil

    Science.gov (United States)

    Hoyer, Annemarie

    Technetium-99m is the most widely used nuclear isotope in the medical field, with nearly 80 to 85% of all diagnostic imaging procedures. The daughter isotope of molybdenum-99 is currently produced using weapons-grade uranium. A suggested design for aluminum targets carrying low-enriched uranium (LEU) foil is presented for the fulfillment of eliminating highly enriched uranium (HEU) for medical isotope production. The assembly process that this research focuses on is the conventional draw-plug process which is currently used and lastly the sealing process. The research is unique in that it is a systematic approach to explore the optimal target assembly process to produce those targets with the required quality and integrity. Conducting 9 parametric experiments, aluminum tubes with a nickel foil fission-barrier and a surrogate stainless steel foil are assembled, welded and then examined to find defects, to determine residual stresses, and to find the best cost-effective target dimensions. The experimental design consists of 9 assembly combinations that were found through orthogonal arrays in order to explore the significance of each factor. Using probabilistic modeling, the parametric study is investigated using the Taguchi method of robust analysis. Depending on the situation, optimal conditions may be a nominal, a minimized or occasionally a maximized condition. The results will provide the best target design and will give optimal quality with little or no assembly defects.

  7. SPECIFICITY OF SELF-PRESERVATION MOTIVATION IN EXTREME SITUATION

    Directory of Open Access Journals (Sweden)

    Ekaterina Anatolevna Karacheva

    2015-02-01

    Full Text Available The article presents the results of the study motivation of self-preservation in an extreme situation. Usually extreme situation unfold from the point of view of functioning, health, high negative level mental stress and tension. The extreme situation is the situation of human activity to which man acts, carrying out certain activities. The article provides an overview of russian and foreign authors dealing with this problem. Theoretical models of motivation of self-preservation Z. Freud, A. Maslow, G. Murray, M. Magomed-Eminov. The study explores the leading motivation in an extreme situation and analyzed the levels of motivation of self-preservation. The study was conducted in the Afghan veterans, using a method of unfinished sentences and other. Identified two levels of motivation of self-preservation: individual and personal. Revealed that the motivation of self-preservation is the leading motivation in an extreme situation.

  8. Family Business in the Czech Republic: Actual Situation

    Directory of Open Access Journals (Sweden)

    Anastasia PETLINA

    2015-09-01

    Full Text Available Purpose of the article: The purpose of this paper is to define the actual situation of family business on the market, particularly focused on qualities of family business and its strengths or weaknesses. The object of research is the family business as an economical phenomenon. The study includes two subjects: firstly, to find out a specification of the family business, to analyze family ties within the business in accordance with the laws of the Czech Republic or to find out the current economic situation in family business and, secondly, to identify the features of family business as well as the difficulties faced thereby, lying in a base of two main components, namely the family system and the same of entrepreneurship. Methodology/methods: The article was prepared on the basis of general theoretical scientific methods, particularly on those of analysis, synthesis, analogy, comparison, generalization and deduction, or the method of expert estimates. For the analysis of the actual situation in big Czech family business enterprises, it was decided to use the secondary data of a top research-journal for this area, namely the Forbes.cz. In accordance with one of the paper goals, a SWOT analysis was applied to find out the basic strengths and weaknesses of family business. It was decided to verify the received information by interviewing several representatives of the family business in the Czech Republic. Scientific aim: The aim of scientific research is to improve the understanding of family business from the perspective of difficulties faced by family business and its economic perspectives. Findings: The results of this study have allowed the finding of a definition for the family business based on family ties and the laws of the Czech Republic. Another finding is that family business as a motor of the Czech economy has a real potencial for its development and it is able to enhance the Czech economy competitiveness on the world market. In

  9. The Theory about didactical situations used to analyze practice related teaching and learning

    DEFF Research Database (Denmark)

    Aarkrog, Vibe

    2018-01-01

    Based on research showing that the students’ challenges in practice based learning can be located to the transitions between theory and practice, this study focuses on how teachers support the students in these transitions. The theoretical framework is mainly Brousseau’s ‘Theory about didactical...... the results show that the Theory of didactical situations can be a useful framework accomplishing practice related teaching and learning. In the discussion a number of challenges in relation to practice related teaching is highlighted focusing on the relation between the five situations in the theory...... situations’ that defines five situations of practice related teaching. The data includes observations combined with interviews of teachers in relation to various examples of practice related teaching in the social and health care programs. Based on the analysis of three examples of practice related teaching...

  10. Radiation inactivation analysis of enzymes. Effect of free radical scavengers on apparent target sizes

    International Nuclear Information System (INIS)

    Eichler, D.C.; Solomonson, L.P.; Barber, M.J.; McCreery, M.J.; Ness, G.C.

    1987-01-01

    In most cases the apparent target size obtained by radiation inactivation analysis corresponds to the subunit size or to the size of a multimeric complex. In this report, we examined whether the larger than expected target sizes of some enzymes could be due to secondary effects of free radicals. To test this proposal we carried out radiation inactivation analysis on Escherichia coli DNA polymerase I, Torula yeast glucose-6-phosphate dehydrogenase, Chlorella vulgaris nitrate reductase, and chicken liver sulfite oxidase in the presence and absence of free radical scavengers (benzoic acid and mannitol). In the presence of free radical scavengers, inactivation curves are shifted toward higher radiation doses. Plots of scavenger concentration versus enzyme activity showed that the protective effect of benzoic acid reached a maximum at 25 mM then declined. Mannitol alone had little effect, but appeared to broaden the maximum protective range of benzoic acid relative to concentration. The apparent target size of the polymerase activity of DNA polymerase I in the presence of free radical scavengers was about 40% of that observed in the absence of these agents. This is considerably less than the minimum polypeptide size and may reflect the actual size of the polymerase functional domain. Similar effects, but of lesser magnitude, were observed for glucose-6-phosphate dehydrogenase, nitrate reductase, and sulfite oxidase. These results suggest that secondary damage due to free radicals generated in the local environment as a result of ionizing radiation can influence the apparent target size obtained by this method

  11. Polish Hip Hop as a Form of Multiliteracies and Situated Learning

    Science.gov (United States)

    Torrence, Michael L.

    2009-01-01

    The purpose of this ethnographic study was to examine Hip Hop in Poland through the lens of multiliteracies and situated learning. This analysis is concerned with the transmission of Hip Hop to and within Wroclaw, Poland, and its acculturation and assimilation in Wroclaw, Poland. Further, this study seeks to illustrate how professional Polish Hip…

  12. Voyager 1 Saturn targeting strategy

    Science.gov (United States)

    Cesarone, R. J.

    1980-01-01

    A trajectory targeting strategy for the Voyager 1 Saturn encounter has been designed to accomodate predicted uncertainties in Titan's ephemeris while maximizing spacecraft safety and science return. The encounter is characterized by a close Titan flyby 18 hours prior to Saturn periapse. Retargeting of the nominal trajectory to account for late updates in Titan's estimated position can disperse the ascending node location, which is nominally situated at a radius of low expected particle density in Saturn's ring plane. The strategy utilizes a floating Titan impact vector magnitude to minimize this dispersion. Encounter trajectory characteristics and optimal tradeoffs are presented.

  13. L'analyse contrastive: histoire et situation actuelle (Contrastive Analysis: History and Current Situation).

    Science.gov (United States)

    Py, Bernard

    1984-01-01

    It is suggested that it is not between two languages that transfers and interference occur, but within the learner. The learner mediates and constructs this relationship according to acquisition operations, processes, strategies, and stages that contrastive analysis, despite its utility, can neither account for nor predict. (MSE)

  14. The present situation of photo-electric plants in the Sahel zone: Possibilities and limits of a marketing strategy using the example of the Niger. Zur gegenwaertigen Situation photovoltaischer Anlagen in der Sahelzone: Moeglichkeiten und Grenzen einer Vermarktungsstrategie am Beispiel des Niger

    Energy Technology Data Exchange (ETDEWEB)

    Hempel, C. (GTZ - Sonderenergieprogramm Niger, Niamey (Niger))

    1993-01-01

    The report is aimed at three targets: First one deals with the meteorological data as the basis for the technical design of photo-electric plants, secondly there is a short survey of the present situation of photo-electrics in Nigeria (referring also to other Sahel countries), and thirdly, the possibilities and limits of a marketing strategy for photo-electric plants are sketched out for this region. (orig.)

  15. Pedagogical and conflict situations of teacher of physical training

    Directory of Open Access Journals (Sweden)

    Pechko O.M.

    2011-02-01

    Full Text Available The article reveals the essence of pedagogical and conflict situations between teacher and student. Considered ways of solving and preventing pedagogical and conflict situations in school. Principal reasons of conflict situations are selected, situations of activity, conduct and relations. The receptions of influence of teacher of physical culture are separated on personality of schoolchildren. It is well-proven that the profession of teacher of physical culture supposes possibility of conflict situations.

  16. Targeted agents for patients with advanced/metastatic pancreatic cancer: A protocol for systematic review and network meta-analysis.

    Science.gov (United States)

    Di, Baoshan; Pan, Bei; Ge, Long; Ma, Jichun; Wu, Yiting; Guo, Tiankang

    2018-03-01

    Pancreatic cancer (PC) is a devastating malignant tumor. Although surgical resection may offer a good prognosis and prolong survival, approximately 80% patients with PC are always diagnosed as unresectable tumor. National Comprehensive Cancer Network's (NCCN) recommended gemcitabine-based chemotherapy as efficient treatment. While, according to recent studies, targeted agents might be a better available option for advanced or metastatic pancreatic cancer patients. The aim of this systematic review and network meta-analysis will be to examine the differences of different targeted interventions for advanced/metastatic PC patients. We will conduct this systematic review and network meta-analysis using Bayesian method and according to Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) statement. To identify relevant studies, 6 electronic databases including PubMed, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), Web of science, CNKI (Chinese National Knowledge Infrastructure), and CBM (Chinese Biological Medical Database) will be searched. The risk of bias in included randomized controlled trials (RCTs) will be assessed using the Cochrane Handbook version 5.1.0. And we will use GRADE approach to assess the quality of evidence from network meta-analysis. Data will be analyzed using R 3.4.1 software. To the best of our knowledge, this systematic review and network meta-analysis will firstly use both direct and indirect evidence to compare the differences of different targeted agents and targeted agents plus chemotherapy for advanced/metastatic pancreatic cancer patients. This is a protocol of systematic review and meta-analysis, so the ethical approval and patient consent are not required. We will disseminate the results of this review by submitting to a peer-reviewed journal.

  17. The layperson in emergency situations

    OpenAIRE

    Pergola, AM; Araujo, IEM

    2008-01-01

    The layperson's qualification to provide early care in emergency situations and basic life support (BLS) is fundamental to save lives and prevent sequels. The objective was to identify the level of knowledge of lay people about approaching an emergency victim. Structured interviews in non-technical language were used with a 385-subject sample, average age 35.4 (+/- 14.55) years, with more than 50% having a high school or university education. Over 55% of these observed situations with loss of...

  18. System for automatic x-ray-image analysis, measurement, and sorting of laser fusion targets

    International Nuclear Information System (INIS)

    Singleton, R.M.; Perkins, D.E.; Willenborg, D.L.

    1980-01-01

    This paper describes the Automatic X-Ray Image Analysis and Sorting (AXIAS) system which is designed to analyze and measure x-ray images of opaque hollow microspheres used as laser fusion targets. The x-ray images are first recorded on a high resolution film plate. The AXIAS system then digitizes and processes the images to accurately measure the target parameters and defects. The primary goals of the AXIAS system are: to provide extremely accurate and rapid measurements, to engineer a practical system for a routine production environment and to furnish the capability of automatically measuring an array of images for sorting and selection

  19. An analysis of the outdoor recreation and wilderness situation in the United States, 1989-2040: A technical document supporting the 1989 USDA Forest Service RPA Assessment

    Science.gov (United States)

    H. Ken Cordell; John C. Bergstrom; Lawrence A. Hartmann; Donald B. K. English

    1990-01-01

    The Analysis of the Outdoor Recreation and Wilderness Situation in the United States is intended to build upon past studies and to establish a new and better information base on outdoor recreation and wilderness demand and supply. Also, this assessment answers several key questions which will help identify ways to meet demand through the year 2040. Specifically, it is...

  20. [Current situation on new psychoactive substances abuse among methadone maintenance treatment patients in China].

    Science.gov (United States)

    Cheng, Z; Dai, M M; Cao, X B

    2018-04-10

    Methadone maintenance treatment (MMT) greatly contributed to the successful outcomes of prevention and control on both AIDS and drug abuse in China. However, the features on drug abuse changed in the past decades, and the prevalence of new psychoactive substances abuse potentially somehow offset the achievement of MMT. This paper concised the information on research and surveys of this issue that targeting on the current situation, characteristics, related factors and relevant public health problem on new psychoactive substances abuse, among patients who have been on MMT, in China.

  1. Detection of Moving Targets Based on Doppler Spectrum Analysis Technique for Passive Coherent Radar

    Directory of Open Access Journals (Sweden)

    Zhao Yao-dong

    2013-06-01

    Full Text Available A novel method of moving targets detection taking Doppler spectrum analysis technique for Passive Coherent Radar (PCR is provided. After dividing the receiving signals into segments as pulse series, it utilizes the technique of pulse compress and Doppler processing to detect and locate the targets. Based on the algorithm for Pulse-Doppler (PD radar, the equipollence between continuous and pulsed wave in match filtering is proved and details of this method are introduced. To compare it with the traditional method of Cross-Ambiguity Function (CAF calculation, the relationship and mathematical modes of them are analyzed, with some suggestions on parameters choosing. With little influence to the gain of targets, the method can greatly promote the processing efficiency. The validity of the proposed method is demonstrated by offline processing real collected data sets and simulation results.

  2. Break-glass handling exceptional situations in access control

    CERN Document Server

    Petritsch, Helmut

    2014-01-01

    Helmut Petritsch describes the first holistic approach to Break-Glass which covers the whole life-cycle: from access control modeling (pre-access), to logging the security-relevant system state during Break-Glass accesses (at-access), and the automated analysis of Break-Glass accesses (post-access). Break-Glass allows users to override security restrictions in exceptional situations. While several Break-Glass models specific to given access control models have already been discussed in research (e.g., extending RBAC with Break-Glass), the author introduces a generic Break-Glass model. The pres

  3. Molecular Composition Analysis of Distant Targets

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose a system capable of probing the molecular composition of cold solar system targets such as asteroids, comets, planets and moons from a distant vantage....

  4. Health among Swedish employees and financial situation, education, and managerial responsibility: a longitudinal study.

    Science.gov (United States)

    Runeson, Roma; Vingård, Eva; Lampa, Erik; Wahlstedt, Kurt

    2012-11-01

    The present study is part of a 3-year longitudinal study on work and health among employees in the public sector in Sweden. The aim was to study associations between self-rated health (SRH) and financial situation, education, and managerial responsibility. Of the 9003 employees, 7533 answered the baseline questionnaires (84%). Altogether 9373 subjects received the follow-up questionnaire, and 6617 subjects responded (71%). In total 4240 completed the questionnaire on both occasions, and this group comprised the study population. SRH consisted of the response to a single question: 'In general, would you say your health is excellent, very good, good, poor, or very poor?' The health was investigated in terms of the development of health status in the 3-year follow-up. The exposure factors were: financial situation, education, and managerial responsibility. Odds ratios were analysed using logistic regressions. Good financial situation and further education were predictors in maintaining good health and in avoiding poor health. The analysis also indicated the following determinants of sustained good SRH: having a good financial situation (OR 1.99 at baseline and OR 1.87 at follow-up), having a further education compared to lower education (OR 1.17 at baseline), and not having a worsening financial situation between baseline and follow-up (OR 0.53). Financial situation and educational level were important factors that influence the subjective perception of health.

  5. HUNGARIAN AND ROMANIAN COMPANIES FINANCIAL AND LIQUIDITY SITUATION IN THE LIGHT OF ECONOMIC CRISIS

    Directory of Open Access Journals (Sweden)

    Kinga Emese Zsido

    2014-07-01

    situation. The study was completed with the analysis of indebtedness and profitability as well. These indicators can play a big role in the financial and liquidity situation of the companies. The indebtedness ratio shows the presence of large foreign capital, which can help in difficult liquidity moments. But the large amount of foreign capital also presents a risk for the company. The effectiveness level of the company shows the company’s profitability, which is essential for the long–term viability. This comparative analysis paper studies three key years of the economic and financial mondial crisis. The results, the trends of the indicators values hopefully will lead to an increase in trust between the partners.

  6. The situation of radiotherapy in 2011

    International Nuclear Information System (INIS)

    2012-06-01

    Published within the frame of the French 2009-2013 cancer plan, this report proposes an analysis of the situation of radiotherapy in France. More particularly, it analyses the French offer in terms of radiotherapy treatments and the French position in Europe. A second part analyses equipment (accelerators and other equipment) and techniques aimed at radiotherapy treatment preparation and delivery. The following techniques are addressed: three-dimensional conformational, intensity modulation, intracranial and extracranial stereotactic, image-guided, total body irradiation, hadron-therapy, and peri-operative radiotherapy. The last parts analyse the activity of radiotherapy centres in terms of treated patients, of patient age structure, of sessions and preparations, and of treated pathologies, the medical and paramedical personnel in charge of radiotherapy, and financial and cost aspects

  7. Situation awareness with systems of systems

    CERN Document Server

    Tretmans, Jan; Borth, Michael

    2013-01-01

    This book discusses various aspects, challenges, and solutions for developing systems-of-systems for situation awareness, using applications in the domain of maritime safety and security.  Topics include advanced, multi-objective visualization methods for situation awareness, stochastic outlier selection, rule-based anomaly detection, an ontology-based event model for semantic reasoning, new methods for semi-automatic generation of adapters bridging communication gaps, security policies for systems-of-systems, trust assessment, and methods to deal with the dynamics of systems-of-systems in run-time monitoring, testing, and diagnosis. Architectural considerations for designing information-centric systems-of-systems such as situation awareness systems, and an integrated demonstrator implementing many of the investigated aspects, complete the book.

  8. Fire disaster preparedness and situational analysis in higher learning institutions of Tanzania

    Directory of Open Access Journals (Sweden)

    Jacob M. Kihila

    2017-01-01

    Full Text Available Fire disasters are accompanied with devastating impact affecting both lives and properties. The magnitude of the impacts has been severe in places with low levels of fire disaster preparedness. A study was conducted in Dar es Salaam, Tanzania, to investigate the level of fire disaster preparedness considering the availability and condition of firefighting facilities as well as the knowledge on fire management among the selected 10 higher learning institutions. Information for the buildings was obtained from the interviews with the managers of the buildings and field observations; information on the user’s preparedness was obtained from interviews using structured questionnaire conducted with the users of the buildings including the visitors. Results from the studied buildings indicated that 60% of the firefighting facilities were not regularly serviced; 50% stored some hazardous materials; 70% of them had not enough water storage for firefighting purposes; 60% had no identifiable fire assembly points; and 90% of the sessions conducted in the buildings involved more than 100 people in a single venue. Further results indicated that 51% of the respondents were not able to operate the installed firefighting facilities; 80.7% of the respondents had never received any training on firefighting and prevention; 95.6% of the respondents had never participated in any fire drills; and 81.5% of them were not aware of the fire responder’s contacts. General situation indicated that higher learning institutions are not well prepared to manage fire outbreaks suggesting that plans to rectify the situation are imperative.

  9. Analysis and Visualization Tool for Targeted Amplicon Bisulfite Sequencing on Ion Torrent Sequencers.

    Directory of Open Access Journals (Sweden)

    Stephan Pabinger

    Full Text Available Targeted sequencing of PCR amplicons generated from bisulfite deaminated DNA is a flexible, cost-effective way to study methylation of a sample at single CpG resolution and perform subsequent multi-target, multi-sample comparisons. Currently, no platform specific protocol, support, or analysis solution is provided to perform targeted bisulfite sequencing on a Personal Genome Machine (PGM. Here, we present a novel tool, called TABSAT, for analyzing targeted bisulfite sequencing data generated on Ion Torrent sequencers. The workflow starts with raw sequencing data, performs quality assessment, and uses a tailored version of Bismark to map the reads to a reference genome. The pipeline visualizes results as lollipop plots and is able to deduce specific methylation-patterns present in a sample. The obtained profiles are then summarized and compared between samples. In order to assess the performance of the targeted bisulfite sequencing workflow, 48 samples were used to generate 53 different Bisulfite-Sequencing PCR amplicons from each sample, resulting in 2,544 amplicon targets. We obtained a mean coverage of 282X using 1,196,822 aligned reads. Next, we compared the sequencing results of these targets to the methylation level of the corresponding sites on an Illumina 450k methylation chip. The calculated average Pearson correlation coefficient of 0.91 confirms the sequencing results with one of the industry-leading CpG methylation platforms and shows that targeted amplicon bisulfite sequencing provides an accurate and cost-efficient method for DNA methylation studies, e.g., to provide platform-independent confirmation of Illumina Infinium 450k methylation data. TABSAT offers a novel way to analyze data generated by Ion Torrent instruments and can also be used with data from the Illumina MiSeq platform. It can be easily accessed via the Platomics platform, which offers a web-based graphical user interface along with sample and parameter storage

  10. Real-time emergency forecasting technique for situation management systems

    Science.gov (United States)

    Kopytov, V. V.; Kharechkin, P. V.; Naumenko, V. V.; Tretyak, R. S.; Tebueva, F. B.

    2018-05-01

    The article describes the real-time emergency forecasting technique that allows increasing accuracy and reliability of forecasting results of any emergency computational model applied for decision making in situation management systems. Computational models are improved by the Improved Brown’s method applying fractal dimension to forecast short time series data being received from sensors and control systems. Reliability of emergency forecasting results is ensured by the invalid sensed data filtering according to the methods of correlation analysis.

  11. Systems integration of biodefense omics data for analysis of pathogen-host interactions and identification of potential targets.

    Directory of Open Access Journals (Sweden)

    Peter B McGarvey

    2009-09-01

    Full Text Available The NIAID (National Institute for Allergy and Infectious Diseases Biodefense Proteomics program aims to identify targets for potential vaccines, therapeutics, and diagnostics for agents of concern in bioterrorism, including bacterial, parasitic, and viral pathogens. The program includes seven Proteomics Research Centers, generating diverse types of pathogen-host data, including mass spectrometry, microarray transcriptional profiles, protein interactions, protein structures and biological reagents. The Biodefense Resource Center (www.proteomicsresource.org has developed a bioinformatics framework, employing a protein-centric approach to integrate and support mining and analysis of the large and heterogeneous data. Underlying this approach is a data warehouse with comprehensive protein + gene identifier and name mappings and annotations extracted from over 100 molecular databases. Value-added annotations are provided for key proteins from experimental findings using controlled vocabulary. The availability of pathogen and host omics data in an integrated framework allows global analysis of the data and comparisons across different experiments and organisms, as illustrated in several case studies presented here. (1 The identification of a hypothetical protein with differential gene and protein expressions in two host systems (mouse macrophage and human HeLa cells infected by different bacterial (Bacillus anthracis and Salmonella typhimurium and viral (orthopox pathogens suggesting that this protein can be prioritized for additional analysis and functional characterization. (2 The analysis of a vaccinia-human protein interaction network supplemented with protein accumulation levels led to the identification of human Keratin, type II cytoskeletal 4 protein as a potential therapeutic target. (3 Comparison of complete genomes from pathogenic variants coupled with experimental information on complete proteomes allowed the identification and

  12. Situational analysis of lymphatic filariasis morbidity in Ahanta West District of Ghana.

    Science.gov (United States)

    Stanton, Michelle C; Best, Abigail; Cliffe, Matthew; Kelly-Hope, Louise; Biritwum, Nana-Kwadwo; Batsa, Linda; Debrah, Alex

    2016-02-01

    Situational analysis of lymphatic filariasis (LF) morbidity and its management in Ahanta West, Ghana, to identify potential barrier to healthcare for LF patients. Lymphoedema and hydrocoele patients were identified by community health workers from a subset of villages, and were interviewed and participated in focus group discussions to determine their attitudes and practices towards managing their morbidity, and their perceived barriers to accessing care. Local health professionals were also interviewed to obtain their views on the availability of morbidity management services in the district. Sixty-two patients (34 lymphoedema and 28 hydrocoeles) and 13 local health professionals were included in the study. Lymphoedema patients predominantly self-managed their conditions, which included washing with soap and water (61.8%), and exercising the affected area (52.9%). Almost 65% of patients had sought medical assistance at some stage, but support was generally limited to receiving tablets (91%). Local health professionals reported rarely seeing lymphoedema patients, citing stigma and lack of provisions to assist patients as a reason for this. Almost half of hydrocoele patients (44%) chose not to seek medical assistance despite the negative impact it had on their lives. Whilst surgery itself is free with national health insurance, 63% those who had not sought treatment stated that indirect costs of surgery (travel costs, loss of earnings, etc.) were the most prohibitive factor to seeking treatment. The information obtained from this study should now be used to guide future morbidity strategies in building a stronger relationship between the local health services and LF patients, to ultimately improve patients' physical, psychological and economic wellbeing. © 2015 The Authors. Tropical Medicine & International Health Published by John Wiley & Sons Ltd.

  13. IFMIF Li target back-plate design integration and thermo-mechanical analysis

    International Nuclear Information System (INIS)

    Riccardi, B.; Roccella, S.; Micciche, G.

    2006-01-01

    The International Fusion Materials Irradiation Facility (IFMIF) is an accelerator-driven intense neutron source where fusion reactor candidate materials will be tested. The neutron flux is produced by means of a deuteron beam (current 250 mA, energy 40 MeV) that strikes a liquid lithium target circulating in a lithium loop. The support on which the liquid lithium flows, i.e. the back-plate, is the most heavily exposed component to neutron flux. A '' bayonet '' concept solution for the back-plate was proposed by ENEA with the objectives of improving the back-plate reliability and simplifying the remote handling procedures. On the base of this concept, a back-plate mock-up was fabricated and validated. Starting from the findings of the mock up design, a back-plate design integration exercise was carried out in order to check if the back-plate geometrical features are compatible with the target assembly and the Vertical Test Assemblies (VTA). The work carried out has demonstrated that even with the changes operated for the design integration (increase of in-plane dimensions and reduction of thickness) the bayonet concept is able to guarantee a tight connection to the target assembly. A thermo-mechanical analysis of the back-plate has been carried out by means of ABAQUS code. The thermal load used as input for the calculations, i.e. the neutron heat generation, has been estimated by means of Monte Carlo Mc-Delicious code. The two boundary constraint cases (full and minimum contact with target assembly) considered for each back-plate geometry option represent the extreme cases of the real operating condition of the plate. The influence of the contact heat exchange coefficient and the back-plate thickness has been also evaluated. For all these reasons, the results of the analysis can be considered as the domain of variability of the real working conditions. The results show that AISI 316L steel is not suitable as black-plate material: the stress induced in the plate, in

  14. Situation 2002: release monitoring and surveillance of environment of Cea centers

    International Nuclear Information System (INIS)

    2003-07-01

    This publication renders an account of the situation of the releases of liquid and gaseous radioactive effluents, for the year 2002, as well as the radioactivity levels measured in the vicinity of Cea centers through the systematic surveillance of atmosphere, waters, vegetation and milk. An analysis on five years allows to follow their evolution. (N.C.)

  15. Project management in crisis situations

    Directory of Open Access Journals (Sweden)

    Agnieszka Goździewska-Nowicka

    2017-05-01

    Full Text Available In today’s methodologies of project management attention is increasingly paid to the crises-related issues. Modern economy and the turbulent environment cause that an emergingcrisis can pose a serious threat to the implementation of any undertaking. This article focuses on the presentation of the conditions and causes of crisis situations, the essence of projects, and their effective management. The major objective of the paper, however, is to demonstrate how companies implementing projects cope with the occurrence of a crisis situation.

  16. Cyber defense and situational awareness

    CERN Document Server

    Kott, Alexander; Erbacher, Robert F

    2015-01-01

    This book is the first publication to give a comprehensive, structured treatment to the important topic of situational awareness in cyber defense. It presents the subject in a logical, consistent, continuous discourse, covering key topics such as formation of cyber situational awareness, visualization and human factors, automated learning and inference, use of ontologies and metrics, predicting and assessing impact of cyber attacks, and achieving resilience of cyber and physical mission. Chapters include case studies, recent research results and practical insights described specifically for th

  17. Biofuels development in China: Technology options and policies needed to meet the 2020 target

    International Nuclear Information System (INIS)

    Chang, Shiyan; Zhao, Lili; Timilsina, Govinda R.; Zhang, Xiliang

    2012-01-01

    China promulgated the Medium and Long-Term Development Plan for Renewable Energy in 2007, which included sub-targets of 2010 and 2020 for various renewable energy technologies. Almost all the 2010 sub-targets have been met and even surpassed except non-grain fuel ethanol. There is debate surrounding the questions of whether and how the country will be able to meet the 2020 biofuels target. This paper provides the assessment of potential technology pathways to achieve the 2020 target regarding their respective resource potential and supply cost. Barriers and policy options are identified based on broad literatures review. And an overview of biofuels projections is presented to provide insight into the comparison of various policy scenarios. The study shows that China can potentially satisfy non-grain fuel ethanol target by 2020 from technology perspective. But she will probably fall far short of this target if current situations continue. Additional policy efforts are needed. Meanwhile, the target of biodiesel production has high probability to be achieved. However, if given support policies, it will develop better. - Highlights: ► I. Non-grain feedstocks such as cassava, sweet sorghum and sweet potato grown in low productive arable lands or unutilized lands have enough potential to meet ethanol targets in 2020. ► II. If current situations continue, China will fall far short of the 2020 target. ► III. The target of biodiesel production has high probability to be achieved, while, if given support policies, it will develop better. ► IV. Supply cost is one of the major barriers faced by all biofuels pathways. ► V. Various policy measures would be necessary to overcome the costs barriers to biofuels in China.

  18. L2 Writing in Test and Non-test Situations: Process and Product

    Directory of Open Access Journals (Sweden)

    Baraa Khuder

    2015-02-01

    Full Text Available Test writers sometimes complain they cannot perform to their true abilities because of time constraints. We therefore examined differences in terms of process and product between texts produced under test and non-test conditions. Ten L2 postgraduates wrote two argumentative essays, one under test conditions, with only forty minutes being allowed and without recourse to resources, and one under non-test conditions, with unlimited time as well as access to the Internet. Keystroke logging, screen capture software, and stimulated recall protocols were used, participants explaining and commenting on their writing processes. Sixteen writing process types were identified. Higher proportions of the processes of translation and surface revision were recorded in the test situation, while meaningful revision and evaluation were both higher in the non-test situation. There was a statistically significant difference between time allocation for different processes at different stages. Experienced teachers awarded the non-test texts a mean score of almost one point (0.8 higher. A correlational analysis examining the relationship between writing process and product quality showed that while the distribution of writing processes can have an impact on text quality in the test situation, it had no effect on the product in the non-test situation.

  19. Entering into the Unexpected: Managing Resilience in Extreme Situations

    International Nuclear Information System (INIS)

    Guarnieri, F.; Travadel, S.

    2016-01-01

    terms of methodology, we take an interdisciplinary approach driven by a narrative analysis tool for designing cognitive models, which is useful for the analysis and exploration of phenomena. The approach is comparative and rooted in the contextual examination of cases; theory is developed using a process that iterates between empirical data and concepts from a broad range of disciplines (sociology, history, philosophy, science and technology studies). Our work shows the need to go beyond a purely cognitive sensemaking approach, and integrate the macro and meso scales, the material context and the embodied dimension of the making of sense. We propose an interpretative model that integrates these aspects and captures the transition from a ‘normal’ situation to a crisis. We also identify some initial lessons in terms of the management of extreme situations and propose some avenues for future research. (author)

  20. Analysis on Target Detection and Classification in LTE Based Passive Forward Scattering Radar

    Directory of Open Access Journals (Sweden)

    Raja Syamsul Azmir Raja Abdullah

    2016-09-01

    Full Text Available The passive bistatic radar (PBR system can utilize the illuminator of opportunity to enhance radar capability. By utilizing the forward scattering technique and procedure into the specific mode of PBR can provide an improvement in target detection and classification. The system is known as passive Forward Scattering Radar (FSR. The passive FSR system can exploit the peculiar advantage of the enhancement in forward scatter radar cross section (FSRCS for target detection. Thus, the aim of this paper is to show the feasibility of passive FSR for moving target detection and classification by experimental analysis and results. The signal source is coming from the latest technology of 4G Long-Term Evolution (LTE base station. A detailed explanation on the passive FSR receiver circuit, the detection scheme and the classification algorithm are given. In addition, the proposed passive FSR circuit employs the self-mixing technique at the receiver; hence the synchronization signal from the transmitter is not required. The experimental results confirm the passive FSR system’s capability for ground target detection and classification. Furthermore, this paper illustrates the first classification result in the passive FSR system. The great potential in the passive FSR system provides a new research area in passive radar that can be used for diverse remote monitoring applications.

  1. Analysis on Target Detection and Classification in LTE Based Passive Forward Scattering Radar.

    Science.gov (United States)

    Raja Abdullah, Raja Syamsul Azmir; Abdul Aziz, Noor Hafizah; Abdul Rashid, Nur Emileen; Ahmad Salah, Asem; Hashim, Fazirulhisyam

    2016-09-29

    The passive bistatic radar (PBR) system can utilize the illuminator of opportunity to enhance radar capability. By utilizing the forward scattering technique and procedure into the specific mode of PBR can provide an improvement in target detection and classification. The system is known as passive Forward Scattering Radar (FSR). The passive FSR system can exploit the peculiar advantage of the enhancement in forward scatter radar cross section (FSRCS) for target detection. Thus, the aim of this paper is to show the feasibility of passive FSR for moving target detection and classification by experimental analysis and results. The signal source is coming from the latest technology of 4G Long-Term Evolution (LTE) base station. A detailed explanation on the passive FSR receiver circuit, the detection scheme and the classification algorithm are given. In addition, the proposed passive FSR circuit employs the self-mixing technique at the receiver; hence the synchronization signal from the transmitter is not required. The experimental results confirm the passive FSR system's capability for ground target detection and classification. Furthermore, this paper illustrates the first classification result in the passive FSR system. The great potential in the passive FSR system provides a new research area in passive radar that can be used for diverse remote monitoring applications.

  2. Ensemble Sensitivity Analysis of a Severe Downslope Windstorm in Complex Terrain: Implications for Forecast Predictability Scales and Targeted Observing Networks

    Science.gov (United States)

    2013-09-01

    observations, linear regression finds the straight line that explains the linear relationship of the sample. This line is given by the equation y = mx + b...SENSITIVITY ANALYSIS OF A SEVERE DOWNSLOPE WINDSTORM IN COMPLEX TERRAIN: IMPLICATIONS FOR FORECAST PREDICTABILITY SCALES AND TARGETED OBSERVING...SENSITIVITY ANALYSIS OF A SEVERE DOWNSLOPE WINDSTORM IN COMPLEX TERRAIN: IMPLICATIONS FOR FORECAST PREDICTABILITY SCALES AND TARGETED OBSERVING NETWORKS

  3. CONSIDERATIONS REGARDING THE AUDIT OF FINANCIAL SITUATIONS

    OpenAIRE

    Maria-Madalina SALOMIA

    2012-01-01

    In a business world situated on a market that is becoming more and more active both on an international and national level, the audit of financial situations embodies a veritable varied research domain and with favorable advantages for the Romanian business society, as well as for the interest of the business society located outside the Romanian space. From the result of the auditing of financial situations of a entity, various information may be obtained which is used by different groups tha...

  4. Indirect-drive noncryogenic double-shell ignition targets for the National Ignition Facility: Design and analysis

    International Nuclear Information System (INIS)

    Amendt, Peter; Colvin, J.D.; Tipton, R.E.; Hinkel, D.E.; Edwards, M.J.; Landen, O.L.; Ramshaw, J.D.; Suter, L.J.; Varnum, W.S.; Watt, R.G.

    2002-01-01

    Analysis and design of indirect-drive National Ignition Facility double-shell targets with hohlraum temperatures of 200 eV and 250 eV are presented. The analysis of these targets includes the assessment of two-dimensional radiation asymmetry and nonlinear mix. Two-dimensional integrated hohlraum simulations indicate that the x-ray illumination can be adjusted to provide adequate symmetry control in hohlraums specially designed to have high laser-coupling efficiency [Suter et al., Phys. Plasmas 7, 2092 (2000)]. These simulations also reveal the need to diagnose and control localized 10-15 keV x-ray emission from the high-Z hohlraum wall because of strong absorption by the high-Z inner shell. Preliminary estimates of the degree of laser backscatter from an assortment of laser-plasma interactions suggest comparatively benign hohlraum conditions. The application of a variety of nonlinear mix models and phenomenological tools, including buoyancy-drag models, multimode simulations and fall-line optimization, indicates a possibility of achieving ignition, i.e., fusion yields greater than 1 MJ. Planned experiments on the Omega laser will test current understanding of high-energy radiation flux asymmetry and mix-induced yield degradation in double-shell targets

  5. Penalty dynamic programming algorithm for dim targets detection in sensor systems.

    Science.gov (United States)

    Huang, Dayu; Xue, Anke; Guo, Yunfei

    2012-01-01

    In order to detect and track multiple maneuvering dim targets in sensor systems, an improved dynamic programming track-before-detect algorithm (DP-TBD) called penalty DP-TBD (PDP-TBD) is proposed. The performances of tracking techniques are used as a feedback to the detection part. The feedback is constructed by a penalty term in the merit function, and the penalty term is a function of the possible target state estimation, which can be obtained by the tracking methods. With this feedback, the algorithm combines traditional tracking techniques with DP-TBD and it can be applied to simultaneously detect and track maneuvering dim targets. Meanwhile, a reasonable constraint that a sensor measurement can originate from one target or clutter is proposed to minimize track separation. Thus, the algorithm can be used in the multi-target situation with unknown target numbers. The efficiency and advantages of PDP-TBD compared with two existing methods are demonstrated by several simulations.

  6. Penalty Dynamic Programming Algorithm for Dim Targets Detection in Sensor Systems

    Directory of Open Access Journals (Sweden)

    Yunfei Guo

    2012-04-01

    Full Text Available In order to detect and track multiple maneuvering dim targets in sensor systems, an improved dynamic programming track-before-detect algorithm (DP-TBD called penalty DP-TBD (PDP-TBD is proposed. The performances of tracking techniques are used as a feedback to the detection part. The feedback is constructed by a penalty term in the merit function, and the penalty term is a function of the possible target state estimation, which can be obtained by the tracking methods. With this feedback, the algorithm combines traditional tracking techniques with DP-TBD and it can be applied to simultaneously detect and track maneuvering dim targets. Meanwhile, a reasonable constraint that a sensor measurement can originate from one target or clutter is proposed to minimize track separation. Thus, the algorithm can be used in the multi-target situation with unknown target numbers. The efficiency and advantages of PDP-TBD compared with two existing methods are demonstrated by several simulations.

  7. CONSIDERATIONS REGARDING THE AUDIT OF FINANCIAL SITUATIONS

    Directory of Open Access Journals (Sweden)

    Maria-Madalina, Salomia

    2012-01-01

    Full Text Available In a business world situated on a market that is becoming more and more active both on an international and national level, the audit of financial situations embodies a veritable varied research domain and with favorable advantages for the Romanian business society, as well as for the interest of the business society located outside the Romanian space.From the result of the auditing of financial situations of a entity, various information may be obtained which is used by different groups that present opinions, knowledge and divergent interests such as:managers, investors, financial creditors, commercial creditors, clients, suppliers, employees, the government and its institutions, bankers, financial analysts, the public, the business community and other entities who base themselves on the objectivity and integrity of the financial situations audited.

  8. Space-based infrared sensors of space target imaging effect analysis

    Science.gov (United States)

    Dai, Huayu; Zhang, Yasheng; Zhou, Haijun; Zhao, Shuang

    2018-02-01

    Target identification problem is one of the core problem of ballistic missile defense system, infrared imaging simulation is an important means of target detection and recognition. This paper first established the space-based infrared sensors ballistic target imaging model of point source on the planet's atmosphere; then from two aspects of space-based sensors camera parameters and target characteristics simulated atmosphere ballistic target of infrared imaging effect, analyzed the camera line of sight jitter, camera system noise and different imaging effects of wave on the target.

  9. Development of a model of situational leadership in residential care for older people.

    Science.gov (United States)

    Lynch, Brighide M; McCormack, Brendan; McCance, Tanya

    2011-11-01

    The aim of the present study was to present the process used to develop a composite model of situational leadership enacted within a person-centred nursing framework in residential care. Transforming the culture of the residential unit from a restrictive institution to a vibrant community of older adults requires transformational leadership. Situational leadership is one form of transformational leadership, which claims that there is not one leadership style that works in all situations. A model of situational leadership in residential care was developed through a series of systematic steps that identified direct linkages between situational leadership and the main constructs of the Person-Centred Nursing Framework. The process included reviewing the evidence, undertaking a comparative analysis, identifying key concepts, connecting the concepts and developing a model. A conceptual model is presented which integrates person-centredness with leadership thinking in order to effectively impact on the follower's performance in managing the care environment and delivering person-centred care. Currently the model is being utilized in an action research study to evaluate the role of leaders in the practice setting of long-term care. While some of the connecting concepts have been identified in the present study, more work needs to be done to unravel these connections in further study of leaders in practice. © 2011 Blackwell Publishing Ltd.

  10. [Teaching basic life support to the general population. Alumni intervention analysis].

    Science.gov (United States)

    Díaz-Castellanos, M A; Fernández-Carmona, A; Díaz-Redondo, A; Cárdenas-Cruz, A; García-del Moral, R; Martín-Lopez, J; Díaz-Redondo, T

    2014-12-01

    The aim of this study was to investigate the rate at which the alumni of basic life support courses witnessed and intervened in out-of-hospital emergency situations, and to identify the variables characterizing those alumni associated with a greater number of witnessing events and interventions. An analysis of the efficiency of the courses was also carried out. A descriptive, cross-sectional study was made. A district in the province of Almería (Spain). Alumni of a mass basic life support training program targeted to the general population «Plan Salvavidas» conducted between 2003-2009. In 2010 the alumni were administered a telephone survey asking whether they had witnessed an emergency situation since attending the program, with the collection of information related to this emergency situation. Rate of out-of-hospital emergencies witnessed by the alumni. Rate of intervention of the alumni in emergency situations. Variables characterizing alumni with a greater likelihood of witnessing an emergency situation. A total of 3,864 trained alumni were contacted by telephone. Of 1,098 respondents, 63.9% were women, and the mean age was 26.61±10.6 years. Of these alumni, 11.75% had witnessed emergency situations, an average of three years after completing the course. Of these emergencies, 23.3% were identified as cardiac arrest. The alumni intervened in 98% of the possible cases. In 63% of the cases, there was no connection between the alumni and the victim. The majority of the emergency situations occurred in the street and in public spaces. A greater likelihood of witnessing an emergency situation was associated with being a healthcare worker and with being over 18 years of age. The rate of out-of-hospital emergencies witnessed by these alumni after the course was 11.75%. The level of intervention among the alumni was high. The most efficient target population consisted of healthcare workers. Copyright © 2013 Elsevier España, S.L.U. y SEMICYUC. All rights reserved.

  11. Evanescent Acoustic Wave Scattering by Targets and Diffraction by Ripples Graduate Traineeship Award in Ocean Acoustics

    National Research Council Canada - National Science Library

    Osterhoudt, Curtis F; Marston, Philip L

    2007-01-01

    .... The purpose of his research was to improve the understanding of the way that acoustic evanescent waves interact with targets buried in sediments in situations encountered in underwater acoustics...

  12. Is Angiosome-Targeted Angioplasty Effective for Limb Salvage and Wound Healing in Diabetic Foot? : A Meta-Analysis.

    Science.gov (United States)

    Chae, Kum Ju; Shin, Jin Yong

    2016-01-01

    Given that the efficacy of employing angiosome-targeted angioplasty in the treatment of diabetic foot remains controversial, this study was conducted to examine its efficacy. We performed a systematic literature review and meta-analysis using core databases, extracting the treatment modality of angiosome-targeted angioplasty as the predictor variable, and limb salvage, wound healing, and revision rate as the outcome variables. We used the Newcastle-Ottawa Scale to assess the study quality, along with the Cochrane Risk of Bias Tool. We evaluated publication bias using a funnel plot. The search strategy identified 518 publications. After screening these, we selected four articles for review. The meta-analysis revealed that overall limb salvage and wound healing rates were significantly higher (Odds ratio = 2.209, 3.290, p = 0.001, pdiabetic foot was more effective than nonangiosome-targeted angioplasty with respect to wound healing and limb salvage.

  13. Physical Activity Targeted at Maximal Lipid Oxidation: A Meta-Analysis

    Directory of Open Access Journals (Sweden)

    A. J. Romain

    2012-01-01

    Full Text Available Exercise is recognized as a part of the management of obesity and diabetes. Various protocols of exercise are proposed for the management of obesity, diabetes, and other metabolic diseases. One of the strategies proposed by several authors is low intensity endurance training targeted at the level of maximal oxidation. Large series using this technique are lacking. Addressing this issue, we performed a meta-analysis of the studies on anthropometric measurements. From a database of 433 articles, 15 were selected, including 279 subjects with 6 different populations. Studies duration ranged from 2 months to 12 months. Concerning weight loss, in the intervention versus control analysis, five studies with 185 participants were included with a significant effect size favors exercise (P=0.02 without significant heterogeneity (I2=0.0%, P=0.83. Further randomized controlled trials for comparing it with other exercise protocols and defining its dose effectiveness on large samples are needed.

  14. Analysis of the thermomechanical behavior of the IFMIF bayonet target assembly under design loading scenarios

    Energy Technology Data Exchange (ETDEWEB)

    Bernardi, D., E-mail: davide.bernardi@enea.it [ENEA Brasimone, Camugnano, BO (Italy); Arena, P.; Bongiovì, G.; Di Maio, P.A. [Dipartimento di Energia, Ingegneria dell’Informazione e Modelli Matematici, Università di Palermo, Viale delle Scienze, Palermo (Italy); Frisoni, M. [ENEA Bologna, Via Martiri di Monte Sole 4, Bologna (Italy); Miccichè, G.; Serra, M. [ENEA Brasimone, Camugnano, BO (Italy)

    2015-10-15

    In the framework of the IFMIF Engineering Validation and Engineering Design Activities (IFMIF/EVEDA) phase, ENEA is responsible for the design of the European concept of the IFMIF lithium target system which foresees the possibility to periodically replace only the most irradiated and thus critical component (i.e., the backplate) while continuing to operate the rest of the target for a longer period (the so-called bayonet backplate concept). In this work, the results of the steady state thermomechanical analysis of the IFMIF bayonet target assembly under two different design loading scenarios (a “hot” scenario and a “cold” scenario) are briefly reported highlighting the relevant indications obtained with respect to the fulfillment of the design requirements. In particular, the analyses have shown that in the hot scenario the temperatures reached in the target assembly are within the material acceptable limits while in the cold scenario transition below the ductile to brittle transition temperature (DBTT) cannot be excluded. Moreover, results indicate that the contact between backplate and high flux test module is avoided and that the overall structural integrity of the system is assured in both scenarios. However, stress linearization analysis reveals that ITER Structural Design Criteria for In-vessel Components (SDC-IC) design rules are not always met along the selected paths at backplate middle plane section in the hot scenario, thus suggesting the need of a revision of the backplate design or a change of the operating conditions.

  15. An EGR performance evaluation and decision-making approach based on grey theory and grey entropy analysis.

    Science.gov (United States)

    Zu, Xianghuan; Yang, Chuanlei; Wang, Hechun; Wang, Yinyan

    2018-01-01

    Exhaust gas recirculation (EGR) is one of the main methods of reducing NOX emissions and has been widely used in marine diesel engines. This paper proposes an optimized comprehensive assessment method based on multi-objective grey situation decision theory, grey relation theory and grey entropy analysis to evaluate the performance and optimize rate determination of EGR, which currently lack clear theoretical guidance. First, multi-objective grey situation decision theory is used to establish the initial decision-making model according to the main EGR parameters. The optimal compromise between diesel engine combustion and emission performance is transformed into a decision-making target weight problem. After establishing the initial model and considering the characteristics of EGR under different conditions, an optimized target weight algorithm based on grey relation theory and grey entropy analysis is applied to generate the comprehensive evaluation and decision-making model. Finally, the proposed method is successfully applied to a TBD234V12 turbocharged diesel engine, and the results clearly illustrate the feasibility of the proposed method for providing theoretical support and a reference for further EGR optimization.

  16. The situational and time-varying context of routines in television viewing: An event history analysis

    NARCIS (Netherlands)

    Westerik, H.; Renckstorf, K.; Wester, F.P.J.; Lammers, J.G.M.

    2005-01-01

    Building on an action theoretical perspective, it is assumed that most television viewing is a routine response to frequently occurring situations, which together make up everyday life. This interplay between television viewing and everyday life was studied using data from a national survey among

  17. Target Fortification of Breast Milk: How Often Should Milk Analysis Be Done?

    Directory of Open Access Journals (Sweden)

    Niels Rochow

    2015-04-01

    Full Text Available Target fortification (TFO reduces natural macronutrient variation in breast milk (BM. Daily BM analysis for TFO increases neonatal intensive care unit work load by 10–15 min/patient/day and may not be feasible in all nurseries. The variation of macronutrient intake when BM analysis is done for various schedules was studied. In an observational study, we analyzed 21 subsequent samples of native 24-h BM batches, which had been prepared for 10 healthy infants (gestational age 26.1 ± 1.3 weeks, birth weight: 890 ± 210 g. Levels of protein and fat (validated near-infrared milk analyzer, as well as lactose (UPLC-MS/MS generated the database for modelling TFO to meet recommendations of European Society for Paediatric Gastroenterology Hepatology and Nutrition. Intake of macronutrients and energy were calculated for different schedules of BM measurements for TFO (n = 1/week; n = 2/week; n = 3/week; n = 5/week; n = 7/week and compared to native and fixed dose fortified BM. Day-to-day variation of macronutrients (protein 20%, carbohydrate 13%, fat 17%, energy 10% decreased as the frequency of milk analysis increased and was almost zero for protein and carbohydrate with daily measurements. Measurements two/week led to mean macronutrient intake within a range of ±5% of targeted levels. A reduced schedule for macronutrient measurement may increase the practical use of TFO. To what extent the day-to-day variation affects growth while mean intake is stable needs to be studied.

  18. Analysis of the situation room in a FHU: a view of women’s health careAnalysis of the situation room in a FHU: a view of women’s health care

    Directory of Open Access Journals (Sweden)

    Marilia Gabriela da Rocha Vital

    2012-07-01

    Full Text Available Rationale and Objectives: Among the Brazilian health care programs, there is the Program for Integral Attention to Women’s Health (PAISM, which offers full assistance to the female population in accordance with the principles and guidelines of SUS within primary care policy. This study aimed to analyze the monthly monitoring in 2009 and 2010 through epidemiological indicators of the situation room regarding women’s health in a Family Health Unit (FHU of Recife-PE. Methods: This is a descriptive epidemiological, comparative and exploratory study carried out in a FHU of the Health District V, located in Recife-PE and called Planet of the Apes II, a member of PET-Health. A total of eight indicators were assessed, representing 100% of the data in spreadsheets presented in the Situation Room in the abovementioned years. Results: The assessed Family Health Unit, in general, reached the goals established by the Ministry of Health regarding PAISM in the analyzed indicators for prenatal care and collection of cytopathologic specimens for uterine cancer surveillance. Conclusion: The FHU must always be instructed and trained to provide comprehensive care to women’s health, a perspective that includes health promotion, control of the most prevalent diseases in this group and ensuring the right to health. However, it is worth emphasizing that the results shown here cannot be interpreted alone, or be the only source of information and evaluation of care. KEYWORDS: Women’s Health. Primary Health Care. Health Policies

  19. Low-velocity ion stopping in a dense and low-temperature plasma target

    Science.gov (United States)

    Deutsch, Claude; Popoff, Romain

    2007-07-01

    We investigate the stopping specificities involved in the heating of thin foils irradiated by intense ion beams in the 0.3-3 MeV/amu energy range and in close vicinity of the Bragg peak. Considering a swiftly ionized target to eV temperatures before expansion while retaining solid-state density, a typical warm dense matter (WDM) situation thus arises. We stress low Vp stopping through ion diffusion in the given target plasma. This allows to include the case of a strongly magnetized target in a guiding center approximation. We also demonstrate that the ion projectile penetration depth in target is significantly affected by multiple scattering on target electrons. The given plasma target is taken weakly coupled with Maxwell electron either with no magnetic field ( B=0) or strongly magnetized ( B≠0). Dynamical coupling between ion projectiles energy losses and projectiles charge state will also be addressed.

  20. About Stressful Situations

    Science.gov (United States)

    ... make a new friend — plus catch up in social studies. Get support. Find someone to talk to about your situation. Ask for help or advice. Be with people who believe in you, make you laugh, and help you feel good about yourself. Sometimes just a listening ear helps a lot. It helps you know ...