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Sample records for target component fabrication

  1. Fabrication of laser-target components by semiconductor technology

    International Nuclear Information System (INIS)

    Tindall, W.E.

    1979-01-01

    This paper describes the design and fabrication of a unique silicon substrate with which laser-target components can be mass produced. Different sizes and shapes of gold foils from 50 to 3000 microns in diameter and up to 25 microns thick have been produced with this process since 1976

  2. Inertial Confinement Fusion Target Component Fabrication and Technology Development report

    International Nuclear Information System (INIS)

    Steinman, D.

    1994-03-01

    On December 30, 1990, the US Department of Energy entered into a contract with General Atomics (GA) to be the Inertial Confinement Fusion Target Component Fabrication and Technology Development Support contractor. This report documents the technical activities which took place under this contract during the period of October 1, 1992 through September 30, 1993. During this period, GA was assigned 18 tasks in support of the Inertial Confinement Fusion program and its laboratories. These tasks included ''Capabilities Activation'' and ''Capabilities Demonstration'' to enable us to begin production of glass and composite polymer capsules. Capsule delivery tasks included ''Small Glass Shell Deliveries'' and ''Composite Polymer Capsules'' for Lawrence Livermore National Laboratory (LLNL) and Los Alamos National Laboratory (LANL). We also were asked to provide direct ''Onsite Support'' at LLNL and LANL. We continued planning for the transfer of ''Micromachining Equipment from Rocky Flats'' and established ''Target Component Micromachining and Electroplating Facilities'' at GA. We fabricated over 1100 films and filters of 11 types for Sandia National Laboratory and provided full-time onsite engineering support for target fabrication and characterization. We initiated development of methods to make targets for the Naval Research Laboratory. We investigated spherical interferometry, built an automated capsule sorter, and developed an apparatus for calorimetric measurement of fuel fill for LLNL. We assisted LANL in the ''Characterization of Opaque b-Layered Targets.'' We developed deuterated and UV-opaque polymers for use by the University of Rochester's Laboratory for Laser Energetics (UR/LLE) and devised a triple-orifice droplet generator to demonstrate the controlled-mass nature of the microencapsulation process

  3. Inertial confinement fusion target component fabrication and technology development support: Annual report, October 1, 1997 - September 30, 1998

    International Nuclear Information System (INIS)

    Gibson, J.

    1998-12-01

    During this period, General Atomics (GA) and their partner Schafer Corporation were assigned 17 formal tasks in support of the Inertial Confinement Fusion (ICF) program and its five laboratories. A portion of the effort on these tasks included providing direct ''On-site Support'' at Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory (LANL), and Sandia National Laboratory Albuquerque (SNLA). They fabricated and delivered over 1,200 hohlraum mandrels and numerous other micromachined components to LLNL, LANL, and SNLA. They produced more than 1,300 glass and plastic target capsules for LLNL, LANL, SNLA, and the University of Rochester/Laboratory for Laser Energetics (UR/LLE). They also delivered nearly 2,000 various target foils and films for Naval Research Lab (NRL) and UR/LLE in FY98. This report describes these target fabrication activities and the target fabrication and characterization development activities that made the deliveries possible. During FY98, great progress was made by the GA/Schafer-UR/LLE-LANL team in the design, procurement, installation, and testing of the OMEGA Cryogenic Target System (OCTS) that will field cryogenic targets on OMEGA. The design phase was concluded for all components of the OCTS and all major components were procured and nearly all were fabricated. Many of the components were assembled and tested, and some have been shipped to UR/LLE. The ICF program is anticipating experiments at the OMEGA laser and the National Ignition Facility (NIF) which will require targets containing cryogenic layered D 2 or deuterium-tritium (DT) fuel. They are part of the National Cryogenic Target Program and support experiments at LLNL and LANL to generate and characterize cryogenic layers for these targets. They also contributed cryogenic support and developed concepts for NIF cryogenic targets. This report summarizes and documents the technical progress made on these tasks

  4. Inertial confinement fusion target component fabrication and technology development support: Annual report, October 1, 1997--September 30, 1998

    Energy Technology Data Exchange (ETDEWEB)

    Gibson, J. [ed.

    1998-12-01

    During this period, General Atomics (GA) and their partner Schafer Corporation were assigned 17 formal tasks in support of the Inertial Confinement Fusion (ICF) program and its five laboratories. A portion of the effort on these tasks included providing direct ``On-site Support`` at Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory (LANL), and Sandia National Laboratory Albuquerque (SNLA). They fabricated and delivered over 1,200 hohlraum mandrels and numerous other micromachined components to LLNL, LANL, and SNLA. They produced more than 1,300 glass and plastic target capsules for LLNL, LANL, SNLA, and the University of Rochester/Laboratory for Laser Energetics (UR/LLE). They also delivered nearly 2,000 various target foils and films for Naval Research Lab (NRL) and UR/LLE in FY98. This report describes these target fabrication activities and the target fabrication and characterization development activities that made the deliveries possible. During FY98, great progress was made by the GA/Schafer-UR/LLE-LANL team in the design, procurement, installation, and testing of the OMEGA Cryogenic Target System (OCTS) that will field cryogenic targets on OMEGA. The design phase was concluded for all components of the OCTS and all major components were procured and nearly all were fabricated. Many of the components were assembled and tested, and some have been shipped to UR/LLE. The ICF program is anticipating experiments at the OMEGA laser and the National Ignition Facility (NIF) which will require targets containing cryogenic layered D{sub 2} or deuterium-tritium (DT) fuel. They are part of the National Cryogenic Target Program and support experiments at LLNL and LANL to generate and characterize cryogenic layers for these targets. They also contributed cryogenic support and developed concepts for NIF cryogenic targets. This report summarizes and documents the technical progress made on these tasks.

  5. Inertial confinement fusion target component fabrication and technology development support: Annual report, October 1, 1995--September 30, 1996

    International Nuclear Information System (INIS)

    Hoppe, M.

    1997-02-01

    On December 30, 1990, the U.S. Department of Energy entered into a contract with General Atomics (GA) to be the Inertial Confinement Fusion (ICF) Target Component Fabrication and Technology Development Support contractor. In September 1995 this contract ended and a second contract was issued for us to continue this ICF target support work. This report documents the technical activities of the period October 1, 1995 through September 30, 1996. During this period, GA and our partners WJ Schafer Associates (WJSA) and Soane Technologies, Inc. (STI) were assigned 14 formal tasks in support of the Inertial Confinement Fusion program and its five laboratories. A portion of the effort on these tasks included providing direct open-quotes Onsite Supportclose quotes at Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory (LANL), and Sandia National Laboratory Albuquerque (SNLA). We fabricated and delivered over 800 gold-plated hohlraum mandrels to LLNL, LANL and SNLA. We produced nearly 1,200 glass and plastic target capsules for LLNL, LANL, SNLA and University of Rochester/Laboratory for Laser Energetics (UR/LLE). We also delivered over 100 flat foil targets for Naval Research Lab (NRL) and SNLA in FY96. This report describes these target fabrication activities and the target fabrication and characterization development activities that made the deliveries possible. The ICF program is anticipating experiments at the OMEGA laser and the National Ignition Facility (NIF) which will require capsules containing cryogenic layered D 2 or deuterium-tritium (DT) fuel. We are part of the National Cryogenic Target Program to create and demonstrate viable ways to generate and characterize cryogenic layers. Substantial progress has been made on ways to both create and characterize viable layers. During FY96, significant progress was made in the design of the OMEGA Cryogenic Target System that will field cryogenic targets on OMEGA

  6. Fabricating nuclear components

    International Nuclear Information System (INIS)

    Anon.

    1977-01-01

    Activities of the Nuclear Engineering Division of Vickers Ltd., particularly fabrication of long slim tubular components for power reactors and the construction of irradiation loops and rigs, are outlined. The processes include hydraulic forming for fabrication of various types of tubes and outer cases of fuel transfer buckets, various specialised welding operations including some applications of the TIG process, and induction brazing of specialised assemblies. (U.K.)

  7. Inertial confinement fusion target component fabrication and technology development support. Annual report, October 1, 1996 - September 30, 1997

    International Nuclear Information System (INIS)

    Gibson, J.

    1998-03-01

    This report documents the technical activities of the period October 1, 1996 through September 30, 1997. During this period, GA and their partner Schafer Corporation were assigned 13 formal tasks in support of the ICF program and its five laboratories. A portion of the effort on these tasks included providing direct open-quotes Onsite Supportclose quotes at Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory (LANL), and Sandia National Laboratory Albuquerque (SNLA). Over 700 gold-plated hohlraum mandrels were fabricated and delivered to LLNL, LANL and SNLA. More than 1600 glass and plastic target capsules were produced for LLNL, LANL, SNLA and University of Rochester/Laboratory for Laser Energetics (UR/LLE). Nearly 2000 various target foils and films were delivered for Naval Research Lab (NRL) and UR/LLE in FY97. This report describes these target fabrication activities and the target fabrication and characterization development activities that made the deliveries possible. The ICF program is anticipating experiments at the OMEGA laser and the National Ignition Facility (NIF) which will require targets containing cryogenic layered D 2 or deuterium-tritium (DT) fuel. This project is part of the National Cryogenic Target Program and support experiments at LLNL and LANL to generate and characterize cryogenic layers for these targets. During FY97, significant progress was made in the design and component testing of the OMEGA Cryogenic Target System that will field cryogenic targets on OMEGA. This included major design changes, reduction in equipment, and process simplifications. This report summarizes and documents the technical progress made on these tasks

  8. Inertial confinement fusion target component fabrication and technology development support. Annual report, October 1, 1996--September 30, 1997

    Energy Technology Data Exchange (ETDEWEB)

    Gibson, J. [ed.

    1998-03-01

    This report documents the technical activities of the period October 1, 1996 through September 30, 1997. During this period, GA and their partner Schafer Corporation were assigned 13 formal tasks in support of the ICF program and its five laboratories. A portion of the effort on these tasks included providing direct {open_quotes}Onsite Support{close_quotes} at Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory (LANL), and Sandia National Laboratory Albuquerque (SNLA). Over 700 gold-plated hohlraum mandrels were fabricated and delivered to LLNL, LANL and SNLA. More than 1600 glass and plastic target capsules were produced for LLNL, LANL, SNLA and University of Rochester/Laboratory for Laser Energetics (UR/LLE). Nearly 2000 various target foils and films were delivered for Naval Research Lab (NRL) and UR/LLE in FY97. This report describes these target fabrication activities and the target fabrication and characterization development activities that made the deliveries possible. The ICF program is anticipating experiments at the OMEGA laser and the National Ignition Facility (NIF) which will require targets containing cryogenic layered D{sub 2} or deuterium-tritium (DT) fuel. This project is part of the National Cryogenic Target Program and support experiments at LLNL and LANL to generate and characterize cryogenic layers for these targets. During FY97, significant progress was made in the design and component testing of the OMEGA Cryogenic Target System that will field cryogenic targets on OMEGA. This included major design changes, reduction in equipment, and process simplifications. This report summarizes and documents the technical progress made on these tasks.

  9. Inertial confinement fusion target component fabrication and technology development support. Annual report, October 1, 1994--September 30, 1995

    International Nuclear Information System (INIS)

    Hoppe, M.

    1996-05-01

    On December 30, 1990, the US Department of Energy entered into a contract with General Atomics (GA) to be the Inertial Confinement Fusion (ICF) Target Component Fabrication and Technology Development Support contractor. This report documents the technical activities of the period October 1, 1994 through September 30, 1995. During this period, GA was assigned 15 tasks in support of the Inertial Confinement Fusion program and its laboratories. A portion of the effort on these tasks included providing direct ''Onsite Support'' at Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory (LANL), and Sandia National Laboratory Albuquerque (SNLA). The ICF program is anticipating experiments at the National Ignition Facility (NIF) and the OMEGA Upgrade. Both facilities will require capsules containing layered D 2 or deuterium-tritium (D-T) fuel. The authors are part of the National Cryogenic Target Program to create and demonstrate viable ways to generate and characterize cryogenic layers. Progress has been made on ways to both create viable layers and to characterize them. They continued engineering, assembly and testing of equipment for a cryogenic target handling system for University of Rochester's Laboratory for Laser Energetics (UR/LLE) that will fill, transport, layer, and characterize targets filled with cryogenic fuel, and insert these cryogenic targets into the OMEGA Upgrade target chamber for laser implosion experiments. This report summarizes and documents the technical progress made on these tasks

  10. Inertial confinement fusion target component fabrication and technology development support. Annual report, October 1, 1994--September 30, 1995

    Energy Technology Data Exchange (ETDEWEB)

    Hoppe, M. [ed.

    1996-05-01

    On December 30, 1990, the US Department of Energy entered into a contract with General Atomics (GA) to be the Inertial Confinement Fusion (ICF) Target Component Fabrication and Technology Development Support contractor. This report documents the technical activities of the period October 1, 1994 through September 30, 1995. During this period, GA was assigned 15 tasks in support of the Inertial Confinement Fusion program and its laboratories. A portion of the effort on these tasks included providing direct ``Onsite Support`` at Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory (LANL), and Sandia National Laboratory Albuquerque (SNLA). The ICF program is anticipating experiments at the National Ignition Facility (NIF) and the OMEGA Upgrade. Both facilities will require capsules containing layered D{sub 2} or deuterium-tritium (D-T) fuel. The authors are part of the National Cryogenic Target Program to create and demonstrate viable ways to generate and characterize cryogenic layers. Progress has been made on ways to both create viable layers and to characterize them. They continued engineering, assembly and testing of equipment for a cryogenic target handling system for University of Rochester`s Laboratory for Laser Energetics (UR/LLE) that will fill, transport, layer, and characterize targets filled with cryogenic fuel, and insert these cryogenic targets into the OMEGA Upgrade target chamber for laser implosion experiments. This report summarizes and documents the technical progress made on these tasks.

  11. Inertial confinement fusion target component fabrication and technology development support: Annual report, October 1, 1993--September 30, 1994

    Energy Technology Data Exchange (ETDEWEB)

    Hoppe, M. [ed.

    1995-04-01

    On December 30, 1990, the US Department of Energy entered into a contract with General Atomics (GA) to be the Inertial Confinement Fusion (ICF) Target Component Fabrication and Technology Development Support contractor. During the period, GA was assigned 17 tasks in support of the Inertial Confinement Fusion program and its laboratories. This year they achieved full production capabilities for the micromachining, dimensional characterization and gold plating of hohlraums. They fabricated and delivered 726 gold-plated mandrels of 27 different types to LLNL and 48 gold-plated mandrels of two different types to LANL. They achieved full production capabilities in composite capsule production ad delivered in excess of 240 composite capsules. They continuously work to improve performance and capabilities. They were also directed to dismantle, remove, and disposition all equipment at the previous contractor (KMSF) that had radioactive contamination levels low enough that they could be exposed to the general public without radiological constraints. GA was also directed to receive and store the tritium fill equipment. They assisted LANL in the development of techniques for characterization of opaque targets. They developed deuterated and UV-opaque polymers for use by the University of Rochester`s Laboratory for Laser Energetics (UR/LLE) and devised a triple-orifice droplet generator to demonstrate the controlled-mass nature of the microencapsulation process. The ICF program is anticipating experiments at NIF and the Omega Upgrade. Both facilities will require capsules containing layered D{sub 2} or D-T fuel. They continued engineering and assembly of equipment for a cryogenic target handling system for UR/LLE that will fill, transport, layer, and characterize targets filled with cryogenic deuterium or deuterium-tritium fuel, and insert these cryogenic targets into the OMEGA Upgrade target chamber for laser implosion experiments.

  12. Inertial confinement fusion target component fabrication and technology development support: Annual report, October 1, 1993--September 30, 1994

    International Nuclear Information System (INIS)

    Hoppe, M.

    1995-04-01

    On December 30, 1990, the US Department of Energy entered into a contract with General Atomics (GA) to be the Inertial Confinement Fusion (ICF) Target Component Fabrication and Technology Development Support contractor. During the period, GA was assigned 17 tasks in support of the Inertial Confinement Fusion program and its laboratories. This year they achieved full production capabilities for the micromachining, dimensional characterization and gold plating of hohlraums. They fabricated and delivered 726 gold-plated mandrels of 27 different types to LLNL and 48 gold-plated mandrels of two different types to LANL. They achieved full production capabilities in composite capsule production ad delivered in excess of 240 composite capsules. They continuously work to improve performance and capabilities. They were also directed to dismantle, remove, and disposition all equipment at the previous contractor (KMSF) that had radioactive contamination levels low enough that they could be exposed to the general public without radiological constraints. GA was also directed to receive and store the tritium fill equipment. They assisted LANL in the development of techniques for characterization of opaque targets. They developed deuterated and UV-opaque polymers for use by the University of Rochester's Laboratory for Laser Energetics (UR/LLE) and devised a triple-orifice droplet generator to demonstrate the controlled-mass nature of the microencapsulation process. The ICF program is anticipating experiments at NIF and the Omega Upgrade. Both facilities will require capsules containing layered D 2 or D-T fuel. They continued engineering and assembly of equipment for a cryogenic target handling system for UR/LLE that will fill, transport, layer, and characterize targets filled with cryogenic deuterium or deuterium-tritium fuel, and insert these cryogenic targets into the OMEGA Upgrade target chamber for laser implosion experiments

  13. Refractory alloy component fabrication

    International Nuclear Information System (INIS)

    Young, W.R.

    1984-01-01

    Purpose of this report is to describe joining procedures, primarily welding techniques, which were developed to construct reliable refractory alloy components and systems for advanced space power systems. Two systems, the Nb-1Zr Brayton Cycle Heat Receiver and the T-111 Alloy Potassium Boiler Development Program, are used to illustrate typical systems and components. Particular emphasis is given to specific problems which were eliminated during the development efforts. Finally, some thoughts on application of more recent joining technology are presented. 78 figures

  14. Inertial confinement fusion target component fabrication and technology development support. Annual report 10/1/98 through 9/30/99

    International Nuclear Information System (INIS)

    Gibson, Jane

    1999-01-01

    General Atomics (GA) has served as the Inertial Confinement Fusion (ICF) Target Component Fabrication and Technology Development Support contractor for the U.S. Department of Energy since December 30, 1990. This report documents the technical activities of the period October 1, 1998 through September 30, 1999. During this period, GA and our partner Schafer Corporation were assigned 17 formal tasks in support of the ICF program and its five laboratories. A portion of the effort on these tasks included providing direct ''Onsite Support'' at Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory (LANL), and Sandia National Laboratory (SNL). We fabricated and delivered over 1790 hohlraum mandrels and numerous other micromachined components to LLNL, LANL, and SNL. We produced more than 1380 glass and plastic target capsules over a wide range of sizes and designs (plus over 300 near target-quality capsules) for LLNL, LANL, SNL, and University of Rochester/Laboratory for Laser Energetic (UR/LLE). We also delivered various target foils and films for Naval Research Lab (NRL) and UWLLE in FY99. We fabricated a device to polish NIF-sized beryllium shells and prepared a laboratory for the safe operation of beryllium polishing activities. This report describes these target fabrication activities and the target fabrication and characterization development activities that made the deliveries possible. During FY99, the GA/Schafer portion of the GA/Schafer-UR/LLE-LANL team effort for design, procurement, installation, and testing of the OMEGA Cryogenic Target System (OCTS) that will field cryogenic targets on OMEGA was completed. All components of the OCTS were procured, fabricated, assembled, tested, and shipped to UR/LLE. Only minor documentation tasks remain to be done in FY00. The ICF program is anticipating experiments at the OMEGA laser and the National Ignition Facility (NIF) which will require targets containing cryogenic layered D2 or deuterium

  15. Project Plan Remote Target Fabrication Refurbishment Project

    International Nuclear Information System (INIS)

    Bell, Gary L.; Taylor, Robin D.

    2009-01-01

    In early FY2009, the DOE Office of Science - Nuclear Physics Program reinstated a program for continued production of 252 Cf and other transcurium isotopes at the Radiochemical Engineering Development Center (REDC) at Oak Ridge National Laboratory (ORNL). The FY2009 major elements of the workscope are as follows: (1) Recovery and processing of seven transuranium element targets undergoing irradiation at the High Flux Isotope Reactor (HFIR) at ORNL; (2) Development of a plan to manufacture new targets for irradiation beginning in early- to mid-FY10 to supply irradiated targets for processing Campaign 75 (TRU75); and (3) Refurbishment of the target manufacturing equipment to allow new target manufacture in early FY10 The 252 Cf product from processing Campaign 74 (recently processed and currently shipping to customers) is expected to supply the domestic demands for a period of approximately two years. Therefore it is essential that new targets be introduced for irradiation by the second quarter of FY10 (HFIR cycle 427) to maintain supply of 252 Cf; the average irradiation period is ∼10 HFIR cycles, requiring about 1.5 calendar years. The strategy for continued production of 252 Cf depends upon repairing and refurbishing the existing pellet and target fabrication equipment for one additional target production campaign. This equipment dates from the mid-1960s to the late 1980s, and during the last target fabrication campaign in 2005- 2006, a number of component failures and operations difficulties were encountered. It is expected that following the target fabrication and acceptance testing of the targets that will supply material for processing Campaign 75 a comprehensive upgrade and replacement of the remote hot-cell equipment will be required prior to subsequent campaigns. Such a major refit could start in early FY 2011 and would take about 2 years to complete. Scope and cost estimates for the repairs described herein were developed, and authorization for the work

  16. Fabricating plasmonic components for nanophotonics

    DEFF Research Database (Denmark)

    Boltasseva, Alexandra; Nielsen, Rasmus Bundgaard; Jeppesen, Claus

    2009-01-01

    We report on experimental realization of different metal-dielectric structures that are used as surface plasmon polariton waveguides and as plasmonic metamaterials. Fabrication approaches based on different lithographic and deposition techniques are discussed....

  17. Fabrication of ion source components by electroforming

    International Nuclear Information System (INIS)

    Schechter, D.E.; Sluss, F.

    1983-01-01

    Several components of the Oak Ridge National Laboratory (ORNL)/Magnetic Fusion Test Facility (MFTF-B) ion source have been fabricated utilizing an electroforming process. A procedure has been developed for enclosing coolant passages in copper components by electrodepositing a thick (greater than or equal to 0.75-mm) layer of copper (electroforming) over the top of grooves machined into the copper component base. Details of the procedure to fabricate acceleration grids and other ion source components are presented

  18. Laser target fabrication, structure and method for its fabrication

    Science.gov (United States)

    Farnum, Eugene H.; Fries, R. Jay

    1985-01-01

    The disclosure is directed to a laser target structure and its method of fabrication. The target structure comprises a target plate containing an orifice across which a pair of crosshairs are affixed. A microsphere is affixed to the crosshairs and enclosed by at least one hollow shell comprising two hemispheres attached together and to the crosshairs so that the microsphere is juxtapositioned at the center of the shell.

  19. Laser cutting fabrication of magnetic components

    International Nuclear Information System (INIS)

    Neuenschwander, R.T.; Ricardo, A.; Rodrigues, D.; Talarico, F.W.B.; Goncalves da Silva, C.E.T.

    1992-01-01

    Dipole, quadrupole and sextupole prototypes for the LNLS storage ring have been fabricated using 1.5 mm thick, low carbon steel laminations, with the aid of CO 2 laser cutter, reaching an overall dimensional accuracy of ±0.02 mm (standard deviation). The relevant aspects of the technique are presented, together with the results of magnetic and dimensional measurements. The possibility of mass producing these components with the technique is also analyzed. (author) 2 refs.; 6 figs

  20. APT target-blanket fabrication development

    Energy Technology Data Exchange (ETDEWEB)

    Fisher, D.L.

    1997-06-13

    Concepts for producing tritium in an accelerator were translated into hardware for engineering studies of tritium generation, heat transfer, and effects of proton-neutron flux on materials. Small-scale target- blanket assemblies were fabricated and material samples prepared for these performance tests. Blanket assemblies utilize composite aluminum-lead modules, the two primary materials of the blanket. Several approaches are being investigated to produce large-scale assemblies, developing fabrication and assembly methods for their commercial manufacture. Small-scale target-blanket assemblies, designed and fabricated at the Savannah River Site, were place in Los Alamos Neutron Science Center (LANSCE) for irradiation. They were subjected to neutron flux for nine months during 1996-97. Coincident with this test was the development of production methods for large- scale modules. Increasing module size presented challenges that required new methods to be developed for fabrication and assembly. After development, these methods were demonstrated by fabricating and assembling two production-scale modules.

  1. FABRICATION AND CHARACTERIZATION OF FAST IGNITION TARGETS

    International Nuclear Information System (INIS)

    HILL, D.W; CASTILLO, E; CHEN, K.C; GRANT, S.E; GREENWOOD, A.L; KAAE, J.L; NIKROO, A; PAGUIO, S.P; SHEARER, C; SMITH, J.N Jr.; STEPHENS, R.B; STEINMAN, D.A; WALL, J.

    2003-09-01

    OAK-B135 Fast ignition is a novel scheme for achieving laser fusion. A class of these targets involves cone mounted CH shells. The authors have been fabricating such targets with shells with a wide variety of diameters and wall thicknesses for several years at General Atomics. In addition, recently such shells were needed for implosion experiments at Laboratory for Laser Energetics (LLE) that for the first time were required to be gas retentive. Fabrication of these targets requires producing appropriate cones and shells, assembling the targets, and characterization of the assembled targets. The cones are produced using micromachining and plating techniques. The shells are fabricated using the depolymerizable mandrel technique followed by micromachining a hole for the cone. The cone and the shell then need to be assembled properly for gas retention and precisely in order to position the cone tip at the desired position within the shell. Both are critical for the fast ignition experiments. The presence of the cone in the shell creates new challenges in characterization of the assembled targets. Finally, for targets requiring a gas fill, the cone-shell assembly needs to be tested for gas retention and proper strength at the glue joint. This paper presents an overview of the developmental efforts and technical issues addressed during the fabrication of fast ignition targets

  2. LIFE Target Fabrication Research Plan Sept 2008

    Energy Technology Data Exchange (ETDEWEB)

    Miles, R; Biener, J; Kucheyev, S; Montesanti, R; Satcher, J; Spadaccini, C; Rose, K; Wang, M; Hamza, A; Alexander, N; Brown, L; Hund, J; Petzoldt, R; Sweet, W; Goodin, D

    2008-11-10

    The target-system for the baseline LIFE fast-ignition target was analyzed to establish a preliminary estimate for the costs and complexities involved in demonstrating the technologies needed to build a prototype LIFE plant. The baseline fast-ignition target upon which this analysis was developed is shown in Figure 1.0-1 below. The LIFE target-system incorporates requirements for low-cost, high throughput manufacture, high-speed, high accuracy injection of the target into the chamber, production of sufficient energy from implosion and recovery and recycle of the imploded target material residue. None of these functions has been demonstrated to date. Existing target fabrication techniques which lead to current 'hot spot' target costs of {approx}$100,000 per target and at a production rate of 2/day are unacceptable for the LIFE program. Fabrication techniques normally used for low-cost, low accuracy consumer products such as toys must be adapted to the high-accuracy LIFE target. This will be challenge. A research program resulting is the demonstration of the target-cycle technologies needed for a prototype LIFE reactor is expected to cost {approx}$51M over the course of 5 years. The effort will result in targets which will cost an estimated $0.23/target at a rep-rate of 20 Hz or about 1.73M targets/day.

  3. Directed light fabrication of rhenium components

    Energy Technology Data Exchange (ETDEWEB)

    Milewski, J.O.; Thoma, D.J.; Lewis, G.K.

    1997-02-01

    Directed Light Fabrication (DLF) is a direct metal deposition process that fuses powder, delivered by gas into the focal zone of a high powered laser beam to form fully dense near-net shaped components. This is accomplished in one step without the use of molds, dies, forming, pressing, sintering or forging equipment. DLF is performed in a high purity inert environment free from the contaminants associated with conventional processing such as oxide and carbon pickup, lubricants, binding agents, cooling or cleaning agents. Applications using rhenium have historically been limited in part by its workability and cost. This study demonstrates the ability to fuse rhenium metal powder, using a DLF machine, into free standing rods and describes the associated parameter study. Microstructural comparisons between DLF deposited rhenium and commercial rhenium sheet product is performed. This research combined with existing DLF technology demonstrates the feasibility of forming complex rhenium, metal shapes directly from powder.

  4. High volume fabrication of laser targets using MEMS techniques

    International Nuclear Information System (INIS)

    Spindloe, C; Tomlinson, S; Green, J; Booth, N.; Tolley, M K; Arthur, G; Hall, F; Potter, R; Kar, S; Higginbotham, A

    2016-01-01

    The latest techniques for the fabrication of high power laser targets, using processes developed for the manufacture of Micro-Electro-Mechanical System (MEMS) devices are discussed. These laser targets are designed to meet the needs of the increased shot numbers that are available in the latest design of laser facilities. Traditionally laser targets have been fabricated using conventional machining or coarse etching processes and have been produced in quantities of 10s to low 100s. Such targets can be used for high complexity experiments such as Inertial Fusion Energy (IFE) studies and can have many complex components that need assembling and characterisation with high precision. Using the techniques that are common to MEMS devices and integrating these with an existing target fabrication capability we are able to manufacture and deliver targets to these systems. It also enables us to manufacture novel targets that have not been possible using other techniques. In addition, developments in the positioning systems that are required to deliver these targets to the laser focus are also required and a system to deliver the target to a focus of an F2 beam at 0.1Hz is discussed. (paper)

  5. Role of Fabrication on Materials Compatibility in APT Target/Blanket

    International Nuclear Information System (INIS)

    Iyer, N.; Louthan, M.R. Jr.; Dunn, K.; Fisher, D.L.

    1998-09-01

    This paper summarizes several of the options associated with the fabrication of selected target/blanket components. In addition, the materials characterization technologies required to validate these components performance is presented

  6. Fabrication of implanted $^{22}$Na targets

    CERN Multimedia

    2002-01-01

    A knowledge of the $^{22}$Na(p,$\\gamma$)$^{23}$ Mg reaction rate is of significant astrophysical interest. In order to complete previous studies of this reaction, radioactive $^{22}$Na targets of high purity are required. We ask for support to fabricate these targets via the implantation technique at ISOLDE GPS (off—line mode) using $^{22}$Na nuclides in an Al matrix produced in Nov. 1990 at the PSI (Zürich). The $^{22}$Na nuclides are released and ionized in a surface ionisation source, mass-analyzed at ISOLDE GPS, and implanted in a Ni-Ta backing and a C—foil in a special implantation setup.

  7. 49 CFR 192.153 - Components fabricated by welding.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Components fabricated by welding. 192.153 Section....153 Components fabricated by welding. (a) Except for branch connections and assemblies of standard... welding, whose strength cannot be determined, must be established in accordance with paragraph UG-101 of...

  8. Mechanical components: fabrication of major reactor structures

    International Nuclear Information System (INIS)

    Nicholson, S.

    1985-01-01

    The paper examines the validity of criticisms of quality assurance of mechanical plant and welded products within major reactor structures, taking into account experience gained on the AGR's. Various constructive recommendations are made aimed at furthering the objectives of quality assurance in the nuclear industry and making it more cost-effective. Current levels of quality related costs in the fabrication industry are provided as a basis for discussion. (U.K.)

  9. Tenth target fabrication specialists` meeting: Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Foreman, L.R.; Stark, J.C. [comp.

    1995-11-01

    This tenth meeting of specialists in target fabrication for inertial confinement is unique in that it is the first meeting that was completely unclassified. As a result of the new classification, we were able to invite more foreign participation. In addition to participants from the US, UK, and Canada, representatives from France, Japan, and two Russian laboratories attended, about 115 in all. This booklet presents full papers and poster sessions. Indirect and direct drive laser implosions are considered. Typical topics include: polymer or aluminium or resorcinol/formaldehyde shells, laser technology, photon tunneling microscopy as a characterization tool, foams, coatings, hohlraums, and beryllium capsules. Hydrogen, deuterium, tritium, and beryllium are all considered as fuels.

  10. Tenth target fabrication specialists' meeting: Proceedings

    International Nuclear Information System (INIS)

    Foreman, L.R.; Stark, J.C.

    1995-01-01

    This tenth meeting of specialists in target fabrication for inertial confinement is unique in that it is the first meeting that was completely unclassified. As a result of the new classification, we were able to invite more foreign participation. In addition to participants from the US, UK, and Canada, representatives from France, Japan, and two Russian laboratories attended, about 115 in all. This booklet presents full papers and poster sessions. Indirect and direct drive laser implosions are considered. Typical topics include: polymer or aluminium or resorcinol/formaldehyde shells, laser technology, photon tunneling microscopy as a characterization tool, foams, coatings, hohlraums, and beryllium capsules. Hydrogen, deuterium, tritium, and beryllium are all considered as fuels

  11. Fabrication of Micro Components by Electrochemical Deposition

    DEFF Research Database (Denmark)

    Tang, Peter Torben

    The main issue of this thesis is the combination of electrochemical deposition of metals and micro machining. Processes for electroplating and electroless plating of nickel and nickel alloys have been developed and optimised for compatibility with microelectronics and silicon based micromechanics...... of electrochemical machining and traditional machining is compared to micro machining techniques as performed in the field of microelectronics. Various practical solutions and equipment for electrochemical deposition of micro components are demonstrated, as well as the use and experience obtained utilising...

  12. Acidic aqueous uranium electrodeposition for target fabrication

    International Nuclear Information System (INIS)

    Saliba-Silva, A.M.; Oliveira, E.T.; Garcia, R.H.L.; Durazzo, M.

    2013-01-01

    Direct irradiation of targets inside nuclear research or multiple purpose reactors is a common route to produce 99 Mo- 99m Tc radioisotopes. The electroplating of low enriched uranium over nickel substrate might be a potential alternative to produce targets of 235 U. The electrochemistry of uranium at low temperature might be beneficial for an alternative route to produce 99 Mo irradiation LEU targets. Electrodeposition of uranium can be made using ionic and aqueous solutions producing uranium oxide deposits. The performance of uranium electrodeposition is relatively low because a big competition with H 2 evolution happens inside the window of electrochemical reduction potential. This work explores possibilities of electroplating uranium as UO 2 2+ (Uranium-VI) in order to achieve electroplating uranium in a sufficient amount to be commercially irradiated in the future Brazilian RMB reactor. Electroplated nickel substrate was followed by cathodic current electrodeposition from aqueous UO 2 (NO 3 ) 2 solution. EIS tests and modeling showed that a film formed differently in the three tested cathodic potentials. At the lower level, (-1.8V) there was an indication of a double film formation, one overlaying the other with ionic mass diffusion impaired at the interface with nickel substrate as showed by the relatively lower admittance of Warburg component. (author)

  13. Advances in target design and fabrication for experiments on NIF

    Directory of Open Access Journals (Sweden)

    Obrey K.

    2013-11-01

    Full Text Available The ability to build target platforms for National Ignition Facility (NIF is a key feature in LANL's (Los Alamos National Laboratory Target Fabrication Program. We recently built and manufactured the first LANL targets to be fielded on NIF in March 2011. Experiments on NIF require precision component manufacturing and accurate knowledge of the materials used in the targets. The characterization of foams and aerogels, the Be ignition capsule, and machining unique components are of main material focus. One important characterization metric the physics' have determined is that the knowledge of density gradients in foams is important. We are making strides in not only locating these density gradients in aerogels and foams as a result of how they are manufactured and machined but also quantifying the density within the foam using 3D confocal micro x-ray fluorescence (μXRF imaging and 3D x-ray computed tomography (CT imaging. In addition, collaborative efforts between General Atomics (GA and LANL in the characterization of the NIF Ignition beryllium capsule have shown that the copper in the capsule migrates radially from the capsule center.

  14. Optimization benefits analysis in production process of fabrication components

    Science.gov (United States)

    Prasetyani, R.; Rafsanjani, A. Y.; Rimantho, D.

    2017-12-01

    The determination of an optimal number of product combinations is important. The main problem at part and service department in PT. United Tractors Pandu Engineering (shortened to PT.UTPE) Is the optimization of the combination of fabrication component products (known as Liner Plate) which influence to the profit that will be obtained by the company. Liner Plate is a fabrication component that serves as a protector of core structure for heavy duty attachment, such as HD Vessel, HD Bucket, HD Shovel, and HD Blade. The graph of liner plate sales from January to December 2016 has fluctuated and there is no direct conclusion about the optimization of production of such fabrication components. The optimal product combination can be achieved by calculating and plotting the amount of production output and input appropriately. The method that used in this study is linear programming methods with primal, dual, and sensitivity analysis using QM software for Windows to obtain optimal fabrication components. In the optimal combination of components, PT. UTPE provide the profit increase of Rp. 105,285,000.00 for a total of Rp. 3,046,525,000.00 per month and the production of a total combination of 71 units per unit variance per month.

  15. Target fabrication using laser and spark erosion machining

    International Nuclear Information System (INIS)

    Clement, X.; Coudeville, A.; Eyharts, P.; Perrine, J.P.; Rouillard, R.

    1982-01-01

    Fabrication of laser fusion targets requires a number of special techniques. We have developed both laser and spark erosion machining to produce minute parts of complex targets. A high repetition rate YAG laser at double frequency is used to etch various materials. For example, marks or patterns are often necessary on structured or advanced targets. The laser is also used to thin down plastic coated stalks. A spark erosion system has proved to be a versatile tool and we describe current fabrication processes like cutting, drilling, and ultra precise machining. Spark erosion has interesting features for target fabrication: it is a highly controllable and reproducible technique as well as relatively inexpensive

  16. Targets and processes for fabricating same

    Science.gov (United States)

    Adams, Jesse D; Malekos, Steven; Le Galloudec, Nathalie; Korgan, Grant; Cowan, Thomas; Sentoku, Yasuhiko

    2016-05-17

    In particular embodiments, the present disclosure provides targets including a metal layer and defining a hollow inner surface. The hollow inner surface has an internal apex. The distance between at least two opposing points of the internal apex is less than about 15 .mu.m. In particular examples, the distance is less than about 1 .mu.m. Particular implementations of the targets are free standing. The targets have a number of disclosed shaped, including cones, pyramids, hemispheres, and capped structures. The present disclosure also provides arrays of such targets. Also provided are methods of forming targets, such as the disclosed targets, using lithographic techniques, such as photolithographic techniques. In particular examples, a target mold is formed from a silicon wafer and then one or more sides of the mold are coated with a target material, such as one or more metals.

  17. Targets and processes for fabricating same

    Science.gov (United States)

    Cowan, Thomas [Dresden, DE; Malekos, Steven [Reno, NV; Korgan, Grant [Reno, NV; Adams, Jesse [Reno, NV; Sentoku, Yasuhiko [Reno, NV; Le Galloudec, Nathalie [Reno, NV; Fuchs, Julien [Paris, FR

    2012-07-24

    In particular embodiments, the present disclosure provides targets including a metal layer and defining a hollow inner surface. The hollow inner surface has an internal apex. The distance between at least two opposing points of the internal apex is less than about 15 .mu.m. In particular examples, the distance is less than about 1 .mu.m. Particular implementations of the targets are free standing. The targets have a number of disclosed shaped, including cones, pyramids, hemispheres, and capped structures. The present disclosure also provides arrays of such targets. Also provided are methods of forming targets, such as the disclosed targets, using lithographic techniques, such as photolithographic techniques. In particular examples, a target mold is formed from a silicon wafer and then one or more sides of the mold are coated with a target material, such as one or more metals.

  18. Laser fusion target fabrication. Status report, 30 April 1974

    International Nuclear Information System (INIS)

    Fries, R.J.; Farnum, E.H.

    1974-11-01

    The laser fusion target fabrication effort at Los Alamos Scientific Laboratory has been successful in producing targets of the general design requested by, and with a range of parameters acceptable to, the theoretical designers and to the laser/target interaction physics experimentalists. Many novel techniques for handling and measuring the properties of various types of hollow microballoons were developed. (U.S.)

  19. Proceedings of the twelfth target fabrication specialists` meeting

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-04-01

    Research in fabrication for inertial confinement fusion (ICF) comprises at least three broad categories: targets for high energy density physics on existing drivers, ignition capsule fabrication, and cryogenic fuel layer formation. The latter two are being pursued primarily for the National Ignition Facility (NIF). Scientists from over 14 laboratories, universities, and businesses contributed over 100 papers on all aspects of ICF target fabrication. The NIF is well along in construction and photos of poured concrete and exposed steel added to the technical excitement. It was clear from the meeting that there has been significant progress toward the fabrication of an ignition target for NIF and that new techniques are resulting in higher quality targets for high energy density research.

  20. Double-shell target fabrication workshop-2016 report

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Y. Morris [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Oertel, John [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Farrell, Michael [General Atomics, San Diego, CA (United States); Baumann, Ted [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Huang, Haibo [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Nikroo, Abbas [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-01-10

    On June 30, 2016, over 40 representatives from Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory (LANL), General Atomics (GA), Laboratory for Laser Energetics (LLE), Schafer Corporation, and NNSA headquarter attended a double-shell (DS) target fabrication workshop at Livermore, California. Pushered-single-shell (PSS) and DS metalgas platforms potentially have a large impact on programmatic applications. The goal of this focused workshop is to bring together target fabrication scientists, physicists, and designers to brainstorm future PSS and DS target fabrication needs and strategies. This one-day workshop intends to give an overall view of historical information, recent approaches, and future research activities at each participating organization. Five topical areas have been discussed that are vital to the success of future DS target fabrications, including inner metal shells, foam spheres, outer ablators, fill tube assembly, and metrology.

  1. Proceedings of the twelfth target fabrication specialists' meeting

    International Nuclear Information System (INIS)

    1999-01-01

    Research in fabrication for inertial confinement fusion (ICF) comprises at least three broad categories: targets for high energy density physics on existing drivers, ignition capsule fabrication, and cryogenic fuel layer formation. The latter two are being pursued primarily for the National Ignition Facility (NIF). Scientists from over 14 laboratories, universities, and businesses contributed over 100 papers on all aspects of ICF target fabrication. The NIF is well along in construction and photos of poured concrete and exposed steel added to the technical excitement. It was clear from the meeting that there has been significant progress toward the fabrication of an ignition target for NIF and that new techniques are resulting in higher quality targets for high energy density research

  2. An Overview of the Target Fabrication Operations at Lawrence Livermore National Laboratory

    International Nuclear Information System (INIS)

    Hibbard, R L; Bono, M J

    2005-01-01

    The Target Engineering team at Lawrence Livermore National Laboratory (LLNL) builds precision laser targets for the National Ignition Facility (NIF) and the Omega Laser in Rochester, NY, and other experimental facilities. The physics requirements demand precision in these targets, which creates a constant need for innovative manufacturing processes. As experimental diagnostics improve, there is greater demand for precision in fabrication, assembly, metrology, and documentation of as-built targets. The team specializes in meso-scale fabrication with core competencies in diamond turning, assembly, and metrology. Figure 1 shows a typical diamond turning center. The team builds over 200 laser targets per year in batches of five to fifteen targets. Thus, all are small-lot custom builds, and most are novel designs requiring engineering and process development. Component materials are metals, polymers and low density aerogel foams. Custom fixturing is used to locate parts on the Diamond Turning Machines (DTM) and assembly stations. This ensures parts can be repeatably located during manufacturing operations. Most target builds involve a series of fabricating one surface with features and then relocating the components on another fixture to finish the opposite side of the component. These components are then assembled to complete multiple-component targets. These targets are typically built one at a time. Cost and efficiency are issues with production of targets, and the team is developing batch processing techniques to meet precision target specifications and cost goals. Three example target builds will highlight some of the fabrication and material issues faced at LLNL. A low temperature Rayleigh Taylor target shows how multiple precision targets can be fabricated out of a single large disk. The ignition double shell targets highlight the required manufacturing complexity. A low density aerogel target highlights some material handling and assembly issues. The metrology

  3. Modeling fabrication of nuclear components: An integrative approach

    Energy Technology Data Exchange (ETDEWEB)

    Hench, K.W.

    1996-08-01

    Reduction of the nuclear weapons stockpile and the general downsizing of the nuclear weapons complex has presented challenges for Los Alamos. One is to design an optimized fabrication facility to manufacture nuclear weapon primary components in an environment of intense regulation and shrinking budgets. This dissertation presents an integrative two-stage approach to modeling the casting operation for fabrication of nuclear weapon primary components. The first stage optimizes personnel radiation exposure for the casting operation layout by modeling the operation as a facility layout problem formulated as a quadratic assignment problem. The solution procedure uses an evolutionary heuristic technique. The best solutions to the layout problem are used as input to the second stage - a simulation model that assesses the impact of competing layouts on operational performance. The focus of the simulation model is to determine the layout that minimizes personnel radiation exposures and nuclear material movement, and maximizes the utilization of capacity for finished units.

  4. Nuclear target foil fabrication for the Romano Event

    International Nuclear Information System (INIS)

    Weed, J.W.; Romo, J.G. Jr.; Griggs, G.E.

    1984-01-01

    The Vacuum Processes Lab, of LLNL's M.E. Dept. - Material Fabrication Division, was requested to provide 250 coated Parylene target foils for a nuclear physics experiment titled the ROMANO Event. Due to the developmental nature of some of the fabrication procedures, approximately 400 coated foils were produced to satisfy the event's needs. The foils were used in the experiment as subkilovolt x-ray, narrow band pass filters, and wide band ultraviolet filters. This paper is divided into three sections describing: (1) nuclear target foil fabrication, (2) Parylene substrate preparation and production, and (3) foil and substrate inspections

  5. Two component micro injection molding for MID fabrication

    DEFF Research Database (Denmark)

    Islam, Mohammad Aminul; Hansen, Hans Nørgaard; Tang, Peter Torben

    2009-01-01

    Molded Interconnect Devices (MIDs) are plastic substrates with electrical infrastructure. The fabrication of MIDs is usually based on injection molding and different process chains may be identified from this starting point. The use of MIDs has been driven primarily by the automotive sector......, but recently the medical sector seems more and more interested. In particular the possibility of miniaturization of 3D components with electrical infrastructure is attractive. The paper describes possible manufacturing routes and challenges of miniaturized MIDs based on two component micro injection molding...

  6. Commercialized VCSEL components fabricated at TrueLight Corporation

    Science.gov (United States)

    Pan, Jin-Shan; Lin, Yung-Sen; Li, Chao-Fang A.; Chang, C. H.; Wu, Jack; Lee, Bor-Lin; Chuang, Y. H.; Tu, S. L.; Wu, Calvin; Huang, Kai-Feng

    2001-05-01

    TrueLight Corporation was found in 1997 and it is the pioneer of VCSEL components supplier in Taiwan. We specialize in the production and distribution of VCSEL (Vertical Cavity Surface Emitting Laser) and other high-speed PIN-detector devices and components. Our core technology is developed to meet blooming demand of fiber optic transmission. Our intention is to diverse the device application into data communication, telecommunication and industrial markets. One mission is to provide the high performance, highly reliable and low-cost VCSEL components for data communication and sensing applications. For the past three years, TrueLight Corporation has entered successfully into the Gigabit Ethernet and the Fiber Channel data communication area. In this paper, we will focus on the fabrication of VCSEL components. We will present you the evolution of implanted and oxide-confined VCSEL process, device characterization, also performance in Gigabit data communication and the most important reliability issue

  7. Advanced laser fusion target fabrication research and development proposal

    International Nuclear Information System (INIS)

    Stupin, D.M.; Fries, R.J.

    1979-05-01

    A research and development program is described that will enable the fabrication of 10 6 targets/day for a laser fusion prototype power reactor in 2007. We give personnel and cost estimates for a generalized laser fusion target that requires the development of several new technologies. The total cost of the program between 1979 and 2007 is $362 million in today's dollars

  8. Two-component microinjection moulding for MID fabrication

    DEFF Research Database (Denmark)

    Islam, Aminul; Hansen, Hans Nørgaard; Tang, Peter Torben

    2010-01-01

    Moulded interconnect devices (MIDs) are plastic substrates with electrical infrastructure. The fabrication of MIDs is usually based on injection moulding, and different process chains may be identified from this starting point. The use of MIDs has been driven primarily by the automotive sector......, but recently, the medical sector seems more and more interested. In particular, the possibility of miniaturisation of three-dimensional components with electrical infrastructure is attractive. The present paper describes possible manufacturing routes and challenges of miniaturised MIDs based on two...

  9. The fabrication of nozzles for nuclear components by welding

    International Nuclear Information System (INIS)

    Moraes, M.M.; Krausser, P.; Echeverria, J.A.V.

    1986-01-01

    A nozzle with medium outside diameter of 1000 mm and medium thickness of 150 mm composed integrally by deposited metal by submerged-arc (wire S3NiMo1, 0.5mm) was fabricated in NUCLEP. The nondestructive, mechanical, metallographic and chemical testing carried out in a test sample made by the same procedure and welding parameters, showed results according to specifications established for primary components for nuclear power plants, and the tests presented mechanical properties and tenacity better than similar nozzle samples. This nozzle is cheapest concerning to importations, in respecting to its forged similar. (M.C.K.) [pt

  10. Fabrication of Complex Optical Components From Mold Design to Product

    CERN Document Server

    Riemer, Oltmann; Gläbe, Ralf

    2013-01-01

    High quality optical components for consumer products made of glass and plastic are mostly fabricated by replication. This highly developed production technology requires several consecutive, well-matched processing steps called a "process chain" covering all steps from mold design, advanced machining and coating of molds, up to the actual replication and final precision measurement of the quality of the optical components. Current market demands for leading edge optical applications require high precision and cost effective parts in large volumes. For meeting these demands it is necessary to develop high quality process chains and moreover, to crosslink all demands and interdependencies within these process chains. The Transregional Collaborative Research Center "Process chains for the replication of complex optical elements" at Bremen, Aachen and Stillwater worked extensively and thoroughly in this field from 2001 to 2012. This volume will present the latest scientific results for the complete process chain...

  11. Fabricating plasmonic components for nano-and meta-photonics

    DEFF Research Database (Denmark)

    Boltasseva, Alexandra; Nielsen, Rasmus Bundgaard; Jeppesen, Claus

    2009-01-01

    Different fabrication approaches for realization of metal-dielectric structures supporting propagating and localized surface plasmons are described including fabrication of nanophotonic waveguides and plasmonic nanoantennae....

  12. Energy efficiency improvement target for SIC 34 - fabricated metal products

    Energy Technology Data Exchange (ETDEWEB)

    Byrer, T. G.; Billhardt, C. F.; Farkas, M. S.

    1977-03-15

    A March 15, 1977 revision of a February 15, 1977 document on the energy improvement target for the Fabricated Metal Products industry (SIC 34) is presented. A net energy savings in 1980 of 24% as compared with 1972 energy consumption in SIC 34 is considered a realistic goal. (ERA citation 04:045008)

  13. Mechanical testing of PHWR components at different fabrication stages

    International Nuclear Information System (INIS)

    Saibaba, N.

    2007-01-01

    Zirconium alloys are extensively used for reactor structural and cladding components for PHWRs and BWRs due to their low neutron absorption cross-section, corrosion resistance to high temperature aqueous environments, adequate mechanical properties and resistance to radiation damage. The coolant tube fabrication route consists of a series of intermediate process steps. The working parameters of each process have a definite bearing on the final properties of these tubes. In order to ascertain the effect of these parameters, mechanical testing is carried out at intermediate stage of coolant tube fabrication. The mechanical properties of the products can be correlated with process parameters and reflect the quality of the product to a great extent. These properties at intermediate stages can serve as process controlling parameters. This paper discusses the correlation of mechanical properties of pressure tubes between the intermediate stage and final stage. The effect of process parameters like annealing temperature, honing, sand blasting pressure and eccentricity on the final mechanical properties was highlighted. (author)

  14. Design and Fabrication of Titanium Target for Portable Neutron Generator

    International Nuclear Information System (INIS)

    Lee, Cheol Ho; Oh, Byunghoon; Chang, Daesik; Jang, Dohyun; In Sang Yeol; Park, Jaewon; Hong, Kwangpyo

    2014-01-01

    For the neutron generator to produce a neutron flux of the above order, a target that produces fast neutrons in the generator plays an important role, and the target is used and applied to develop the generator due to its simplicity and inexpensive. Making suitable targets for neutron production, especially mono-energy neutrons, has always been of interest. These targets have been used for neutron production reaction studies, calibration of detectors, and neutron therapy. Different studies have been carried out on deuterium and tritium for making solid targets to produce mono-energy neutron from D-D and D-T reactions. A lot of investigations have been carried out on solid target properties such as lifetime, thermal stability, neutron yield, and energy. Vaporized zirconium and titanium layers on a high thermal conductivity substrate (Cu, Mo, Ag) have been used as deuterium and tritium absorbing metals. The density of titanium is smaller than zirconium and the range of charged particles in the titanium targets is more than that in zirconium targets. Thus, titanium targets have more neutron yield than zirconium targets in a low energy beam and titanium is usually used to make a target. The titanium target was designed and simulated to determine the suitable thickness of the target. As a result of the simulation, the target was fabricated to generate fast neutrons by the reaction. The thickness of the target was measured using a profiler. The thickness of the two targets is 2.108 and 2.190 μm. The target will be applied to produce neutrons in a neutron generator

  15. COST-EFFECTIVE TARGET FABRICATION FOR INERTIAL FUSION ENERGY

    International Nuclear Information System (INIS)

    GOODIN, D.T; NOBILE, A; SCHROEN, D.G; MAXWELL, J.L; RICKMAN, W.S

    2004-03-01

    A central feature of an Inertial Fusion Energy (IFE) power plant is a target that has been compressed and heated to fusion conditions by the energy input of the driver. The IFE target fabrication programs are focusing on methods that will scale to mass production, and working closely with target designers to make material selections that will satisfy a wide range of required and desirable characteristics. Targets produced for current inertial confinement fusion experiments are estimated to cost about $2500 each. Design studies of cost-effective power production from laser and heavy-ion driven IFE have found a cost requirement of about $0.25-0.30 each. While four orders of magnitude cost reduction may seem at first to be nearly impossible, there are many factors that suggest this is achievable. This paper summarizes the paradigm shifts in target fabrication methodologies that will be needed to economically supply targets and presents the results of ''nth-of-a-kind'' plant layouts and concepts for IFE power plant fueling. Our engineering studies estimate the cost of the target supply in a fusion economy, and show that costs are within the range of commercial feasibility for laser-driven and for heavy ion driven IFE

  16. Engineering design and fabrication of X-Band components

    CERN Document Server

    Filippova, M; Solodko, A; Riddone, G; Syratchev, I

    2011-01-01

    The CLIC RF frequency has been changed in 2008 from the initial 30 GHz to the European X-band 11.994 GHz permitting beam independent power production using klystrons for the accelerating structure testing. X-band klystron test facilities at 11.424 GHz are operated at SLAC and at KEK [1], and they are used by the CLIC study in the framework of the X-band structure collaboration for testing accelerating structures scaled to that frequency [2]. CERN is currently building a klystron test-stand operating at 11.994 GHz. In addition X-FEL projects at PSI and Sincrotrone Trieste operate at 11.4 GHz. Therefore several RF components accommodating frequencies from 11.424 to 11.994 GHz are required. The engineering design of these RF components (high power and compact loads, bi-directional couplers, X-band splitters, hybrids, phase shifters, variable power attenuators) and the main fabrication processes are presented here.

  17. LBNF 1.2 MW TARGET: CONCEPTUAL DESIGN & FABRICATION

    Energy Technology Data Exchange (ETDEWEB)

    Crowley, Cory F. [Fermilab; Ammigan, K. [Fermilab; Anderson, K. [Fermilab; Hartsell, B. [Fermilab; Hurh, P. [Fermilab; Hylen, J. [Fermilab; Zwaska, R. [Fermilab

    2015-06-29

    Fermilab’s Long-Baseline Neutrino Facility (LBNF) will utilize a modified design based on the NuMI low energy target that is reconfigured to accommodate beam operation at 1.2 MW. Achieving this power with a graphite target material and ancillary systems originally rated for 400 kW requires several design changes and R&D efforts related to material bonding and electrical isolation. Target cooling, structural design, and fabrication techniques must address higher stresses and heat loads that will be present during 1.2 MW operation, as the assembly will be subject to cyclic loads and thermal expansion. Mitigations must be balanced against compromises in neutrino yield. Beam monitoring and subsystem instrumentation will be updated and added to ensure confidence in target positioning and monitoring. Remote connection to the target hall support structure must provide for the eventual upgrade to a 2.4 MW target design, without producing excessive radioactive waste or unreasonable exposure to technicians during reconfiguration. Current designs and assembly layouts will be presented, in addition to current findings on processes and possibilities for prototype and final assembly fabrication.

  18. LBNF 1.2 MW Target: Conceptual Design & Fabrication

    Energy Technology Data Exchange (ETDEWEB)

    Crowley, C. [Fermilab; Ammigan, K. [Fermilab; Anderson, K. [Fermilab; Hartsell, B. [Fermilab; Hurh, P. [Fermilab; Hylen, J. [Fermilab; Zwaska, R. [Fermilab

    2015-06-01

    Fermilab’s Long-Baseline Neutrino Facility (LBNF) will utilize a modified design based on the NuMI low energy target that is reconfigured to accommodate beam operation at 1.2 MW. Achieving this power with a graphite target material and ancillary systems originally rated for 400 kW requires several design changes and R&D efforts related to material bonding and electrical isolation. Target cooling, structural design, and fabrication techniques must address higher stresses and heat loads that will be present during 1.2 MW operation, as the assembly will be subject to cyclic loads and thermal expansion. Mitigations must be balanced against compromises in neutrino yield. Beam monitoring and subsystem instrumentation will be updated and added to ensure confidence in target positioning and monitoring. Remote connection to the target hall support structure must provide for the eventual upgrade to a 2.4 MW target design, without producing excessive radioactive waste or unreasonable exposure to technicians during reconfiguration. Current designs and assembly layouts will be presented, in addition to current findings on processes and possibilities for prototype and final assembly fabrication.

  19. Concepts for fabrication of inertial fusion energy targets

    Energy Technology Data Exchange (ETDEWEB)

    Nobile, A. (Arthur), Jr.; Hoffer, J. K. (James K.); Gobby, P. L. (Peter L.); Steckle, W. P. (Warren P.), Jr.; Goodin, D. T. (Daniel T.); Besenbruch, G. E. (Gottfried E.); Schultz, K. R. (Kenneth R.)

    2001-01-01

    Future inertial fusion energy (IFE) power plants will have a Target Fabrication Facility (TFF) that must produce approximately 500,000 targets per day. To achieve a relatively low cost of electricity, the cost to produce these targets will need to be less than approximately $0.25 per target. In this paper the status on the development of concepts for a TFF to produce targets for a heavy ion fusion (HIF) reactor, such as HYLIFE II, and a laser direct drive fusion reactor such as Sombrero, is discussed. The baseline target that is produced in the HIF TFF is similar to the close-coupled indirect drive target designed by Callahan-Miller and Tabak at Lawrence Livermore Laboratory. This target consists of a cryogenic hohlraum that is made of a metal case and a variety of metal foams and metal-doped organic foams. The target contains a DT-filled CH capsule. The baseline direct drive target is the design developed by Bodner and coworkers at Naval Research Laboratory. HIF targets can be filled with DT before or after assembly of the capsule into the hohlraum. Assembly of targets before filling allows assembly operations to be done at room temperature, but tritium inventories are much larger due to the large volume that the hohlraum occupies in the fill system. Assembly of targets cold after filling allows substantial reduction in tritium inventory, but this requires assembly of targets at cryogenic temperature. A model being developed to evaluate the tritium inventories associated with each of the assembly and fill options indicates that filling targets before assembling the capsule into the hohlraum, filling at temperatures as high as possible, and reducing dead-volumes in the fill system as much as possible offers the potential to reduce tritium inventories to acceptable levels. Use of enhanced DT ice layering techniques, such as infrared layering can reduce tritium inventories significantly by reducing the layering time and therefore the number of capsules being layered

  20. Information management data base for fusion target fabrication processes

    International Nuclear Information System (INIS)

    Reynolds, J.

    1983-01-01

    A computer-based data management system has been developed to handle data associated with target fabrication processes including glass microballoon characterization, gas filling, materials coating, and storage locations. The system provides automatic data storage and computation, flexible data entry procedures, fast access, automated report generation, and secure data transfer. It resides on a CDC CYBER 175 computer and is compatible with the CDC data base language Query Update, but is based on custom fortran software interacting directly with the CYBER's file management system. The described data base maintains detailed, accurate, and readily available records of fusion targets information

  1. Fabrication and characterization of cryogenic targets for inertial confinement fusion

    International Nuclear Information System (INIS)

    Rieger, H.; Kim, K.

    1979-08-01

    A new technique has been developed which is capable of fabricating uniform cryogenic targets for use in inertial confinement fusion. The essence of the technique is to directly wet a target with a cold helium gas jet, which results in freezing of the DT mixture contained in the target. A controlled amount of current is pulsed through a heater wire surrounding the target, giving rise to fast evaporation and refreezing of the DT-condensate into a uniform layer. Experiments, which have been performed with D 2 -filled glass microshells, successfully produce uniform layers of both liquid and solid D 2 inside the glass shells. A set of data illustrating the technique is presented and analyzed

  2. Powder Metallurgy Fabrication of Molybdenum Accelerator Target Disks

    Energy Technology Data Exchange (ETDEWEB)

    Lowden, Richard Andrew [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Kiggans Jr., James O. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Nunn, Stephen D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Parten, Randy J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-07-01

    Powder metallurgy approaches for the fabrication of accelerator target disks are being examined to support the development of Mo-99 production by NorthStar Medical Technologies, LLC. An advantage of powder metallurgy is that very little material is wasted and, at present, dense, quality parts are routinely produced from molybdenum powder. The proposed targets, however, are thin wafers, 29 mm in diameter with a thickness of 0.5 mm, with very stringent dimensional tolerances. Although tooling can be machined to very high tolerance levels, the operations of powder feed, pressing and sintering involve complicated mechanisms, each of which affects green density and shrinkage, and therefore the dimensions and shape of the final product. Combinations of powder morphology, lubricants and pressing technique have been explored to produce target disks with minimal variations in thickness and little or no distortion. In addition, sintering conditions that produce densities for optimum target dissolvability are being determined.

  3. Prediction of Corrosion of Advanced Materials and Fabricated Components

    Energy Technology Data Exchange (ETDEWEB)

    A. Anderko; G. Engelhardt; M.M. Lencka (OLI Systems Inc.); M.A. Jakab; G. Tormoen; N. Sridhar (Southwest Research Institute)

    2007-09-29

    The goal of this project is to provide materials engineers, chemical engineers and plant operators with a software tool that will enable them to predict localized corrosion of process equipment including fabricated components as well as base alloys. For design and revamp purposes, the software predicts the occurrence of localized corrosion as a function of environment chemistry and assists the user in selecting the optimum alloy for a given environment. For the operation of existing plants, the software enables the users to predict the remaining life of equipment and help in scheduling maintenance activities. This project combined fundamental understanding of mechanisms of corrosion with focused experimental results to predict the corrosion of advanced, base or fabricated, alloys in real-world environments encountered in the chemical industry. At the heart of this approach is the development of models that predict the fundamental parameters that control the occurrence of localized corrosion as a function of environmental conditions and alloy composition. The fundamental parameters that dictate the occurrence of localized corrosion are the corrosion and repassivation potentials. The program team, OLI Systems and Southwest Research Institute, has developed theoretical models for these parameters. These theoretical models have been applied to predict the occurrence of localized corrosion of base materials and heat-treated components in a variety of environments containing aggressive and non-aggressive species. As a result of this project, a comprehensive model has been established and extensively verified for predicting the occurrence of localized corrosion as a function of environment chemistry and temperature by calculating the corrosion and repassivation potentials.To support and calibrate the model, an experimental database has been developed to elucidate (1) the effects of various inhibiting species as well as aggressive species on localized corrosion of nickel

  4. Addressing key science and technology issues for IFE chambers, target fabrication and target injection

    International Nuclear Information System (INIS)

    Meier, W.R.; Goodin, D.T.; Nobile, A.

    2003-01-01

    Significant progress has been made in the development of high repetition rate chambers, target fabrication and injection for inertial fusion energy (IFE) for both heavy ion and laser drivers. Research is being conducted in a coordinated manner by national laboratories, universities and industry. This paper provides an overview of U.S. research activities and discusses how interface considerations (such as beam propagation and target survival during injection) impact design choices. (author)

  5. THE STUDY OF THE CHARACTERIZATION INDICES OF FABRICS BY PRINCIPAL COMPONENT ANALYSIS METHOD

    OpenAIRE

    HRISTIAN Liliana; OSTAFE Maria Magdalena; BORDEIANU Demetra Lacramioara; APOSTOL Laura Liliana

    2017-01-01

    The paper was pursued to prioritize the worsted fabrics type, for the manufacture of outerwear products by characterization indeces of fabrics, using the mathematical model of Principal Component Analysis (PCA). There are a number of variables with a certain influence on the quality of fabrics, but some of these variables are more important than others, so it is useful to identify those variables to a better understanding the factors which can lead the improving of the fabrics quality. A s...

  6. Multi-Step Deep Reactive Ion Etching Fabrication Process for Silicon-Based Terahertz Components

    Science.gov (United States)

    Jung-Kubiak, Cecile (Inventor); Reck, Theodore (Inventor); Chattopadhyay, Goutam (Inventor); Perez, Jose Vicente Siles (Inventor); Lin, Robert H. (Inventor); Mehdi, Imran (Inventor); Lee, Choonsup (Inventor); Cooper, Ken B. (Inventor); Peralta, Alejandro (Inventor)

    2016-01-01

    A multi-step silicon etching process has been developed to fabricate silicon-based terahertz (THz) waveguide components. This technique provides precise dimensional control across multiple etch depths with batch processing capabilities. Nonlinear and passive components such as mixers and multipliers waveguides, hybrids, OMTs and twists have been fabricated and integrated into a small silicon package. This fabrication technique enables a wafer-stacking architecture to provide ultra-compact multi-pixel receiver front-ends in the THz range.

  7. Conceptual design of low activation target chamber and components for the National Ignition Facility

    International Nuclear Information System (INIS)

    Streckert, H.H.; Schultz, K.R.; Sager, G.T.; Kantner, R.D.

    1996-01-01

    The baseline design for the target chamber and chamber components for the National Ignition Facility (NIF) consists of aluminum alloy structural material. Low activation composite chamber and components have important advantages including enhanced environmental and safety characteristics and improved accessibility due to reduced neutron-induced radioactivity. A low activation chamber can be fabricated from carbon fiber reinforced epoxy using thick wall laminate technology similar to submarine bow dome fabrication for the U.S. Navy. A risk assessment analysis indicates that a composite chamber has a reasonably high probability of success, but that an aluminum alloy chamber represents a lower risk. Use of low activation composite materials for several chamber components such as the final optics assemblies, the target positioner and inserter, the diagnostics manipulator tubes, and the optics beam tubes would offer an opportunity to make significant reductions in post-shot radiation dose rate with smaller, less immediate impact on the NIF design. 7 refs., 3 figs

  8. Fabrication details for wire wrapped fuel assembly components

    International Nuclear Information System (INIS)

    Bosy, B.J.

    1978-09-01

    Extensive hydraulic testing of simulated LMFBR blanket and fuel assemblies is being carried out under this MIT program. The fabrication of these test assemblies has involved development of manufacturing procedures involving the wire wrapped pins and the flow housing. The procedures are described in detail in the report

  9. Fabrication of micro-optical components using femtosecond oscillator pulses

    Science.gov (United States)

    Rodrigues, Vanessa R. M.; Ramachandran, Hema; Chidangil, Santhosh; Mathur, Deepak

    2017-06-01

    With a penchant for integrated photonics and miniaturization, the fabrication of micron sized optical elements using precision laser pulse management is drawing attention due to the possibility of minimizing tolerances for collateral material damage. The work presented here deals with the design, fabrication and characterization of a range of diffractive optics - gratings, grids and Fresnel zone plates - on transparent and metallic samples. Their low volume, light weight, transmission bandwidth, high damage threshold and flexible design make them suited for replacing conventional refractive optical elements. Our one-step, mask-less, 3-D laser direct writing process is a green fabrication technique which is in stark contrast to currently popular Photo-lithography based micro-structuring. Our method provides scope for modifications on the surface as well as within the bulk of the material. The mechanism involved in the fabrication of these optics on transparent and thin metallic substrates differ from each other. Our studies show that both amplitude and phase versions of micro-structures were achieved successfully with performances bearing 98% accuracy vis-a-vis theoretical expectations.

  10. Energy efficiency improvement target for SIC 34 - fabricated metal products. Revised target support document

    Energy Technology Data Exchange (ETDEWEB)

    Byrer, T. G.; Billhardt, C. F.; Farkas, M. S.

    1977-02-15

    In accordance with section 374 of the Energy Policy and Conservation Act (EPCA), Pub. L. 94-163, the Federal Energy Administration (FEA) proposed industrial energy efficiency improvement targets for the ten most energy-consumptive manufacturing industries in the U.S. Following public hearings and a review of the comments made, the final targets for Fabricated Metal Products (SIC 34) were established and are described. Using 1972 data on the energy consumed to produce specific metal products, it was concluded that a 24% reduction in energy consumption for SIC 34 is a viable goal for achievement by 1980. (ERA citation 04:045006)

  11. Review of manufacturing processes for fabrication of SOFC components

    International Nuclear Information System (INIS)

    Stacey, B.; Badwal, S.P.S.; Foger, K.

    1998-01-01

    In order for fuel cell technology to be commercial, it must meet stringent criteria of reliability, life-time expectations and cost. While materials play an important role in determining these parameters, engineering design and manufacturing processes for fuel cell stack components are equally important. Manufacturing processes must be low cost and suitable for large volume production for the technology to be viable and competitive in the market place. Several processes suitable for the production of ceramic components used in solid oxide fuel cells as well as ceramic coating techniques required for the protection of some metal components have been described. Copyright (1998) Australasian Ceramic Society

  12. Fabrication development of full-sized components for GCFR core assemblies

    International Nuclear Information System (INIS)

    Lindgren, J.R.; Flynn, P.W.; Foster, L.C.

    1980-05-01

    This paper presents the status of the development of full-sized components for gas-cooled fast reactor (GCFR) core assemblies. Methods for ribbing of the fuel rod cladding, fabrication of grid spacers of two different designs, drawing of assembly flow ducts, and fabrication of fission gas collection manifolds by several methods are discussed

  13. Fabrication of the wing and vertical target dummy armour prototypes of the ITER divertor

    International Nuclear Information System (INIS)

    Grattarola, M.; Bet, M.; Biagiotti, B.; Gandini, G.; Merola, M.; Ottonello, G.B.; Riccardi, B.; Vieider, G.; Zacchia, F.

    2000-01-01

    The dummy armour prototypes are identical to the reference components in terms of geometry, cooling circuit and material except for the armour material, which is replaced by an equivalent thickness of copper alloy. The main objectives of the dummy armour prototypes are the demonstration of the overall engineering concept of the Divertor, the integration in a 3 deg. cassette together with components manufactured by the other ITER Home Teams and the successive thermo-hydraulic tests on the whole Divertor module. This paper describes the realization of both the wing and the vertical target dummy armour prototypes focusing on the critical aspects of the fabrication and their impact on a further industrialization of the components

  14. Fabrication of the wing and vertical target dummy armour prototypes of the ITER divertor

    Energy Technology Data Exchange (ETDEWEB)

    Grattarola, M. E-mail: gratta@ari.ansaldo.it; Bet, M.; Biagiotti, B.; Gandini, G.; Merola, M.; Ottonello, G.B.; Riccardi, B.; Vieider, G.; Zacchia, F

    2000-11-01

    The dummy armour prototypes are identical to the reference components in terms of geometry, cooling circuit and material except for the armour material, which is replaced by an equivalent thickness of copper alloy. The main objectives of the dummy armour prototypes are the demonstration of the overall engineering concept of the Divertor, the integration in a 3 deg. cassette together with components manufactured by the other ITER Home Teams and the successive thermo-hydraulic tests on the whole Divertor module. This paper describes the realization of both the wing and the vertical target dummy armour prototypes focusing on the critical aspects of the fabrication and their impact on a further industrialization of the components.

  15. Fabrication of high performance components for Indian nuclear reactors

    International Nuclear Information System (INIS)

    Jayaraj, R.N.

    2011-01-01

    Nuclear Fuel Complex (NFC), a Unit of the Department of Atomic Energy (DAE) has been engaged for well over three-and-half decades in the manufacture of fuels for Pressurized Heavy Water Reactors (PHWRs) and Boiling Water Reactors (BWRs). All the fuel assembly components, like, fuel clad tubes, end plugs, spacers, spacer grids etc. are also being manufactured at NFC in Zirconium alloy material. Apart from the regular production of these components and finished fuel assemblies, NFC has also been engaged in the production of Zirconium alloy reactor core structurals, like, pressure tubes, calandria tubes, garter springs and reactivity control mechanisms for PHWRs and square channels for BWRs. While all these structural components are produced through standardized flow sheets, there have been continuous innovations carried out in the processes to meet the ever increasing end-use characteristics laid down by the utilities. The paper enumerates various aspects of different technologies developed at NFC for the manufacture of high performance components for reactor applications

  16. Forging of metallic nano-objects for the fabrication of submicron-size components

    International Nuclear Information System (INIS)

    Roesler, J; Mukherji, D; Schock, K; Kleindiek, S

    2007-01-01

    In recent years, nanoscale fabrication has developed considerably, but the fabrication of free-standing nanosize components is still a great challenge. The fabrication of metallic nanocomponents utilizing three basic steps is demonstrated here. First, metallic alloys are used as factories to produce a metallic raw stock of nano-objects/nanoparticles in large numbers. These objects are then isolated from the powder containing thousands of such objects inside a scanning electron microscope using manipulators, and placed on a micro-anvil or a die. Finally, the shape of the individual nano-object is changed by nanoforging using a microhammer. In this way free-standing, high-strength, metallic nano-objects may be shaped into components with dimensions in the 100 nm range. By assembling such nanocomponents, high-performance microsystems can be fabricated, which are truly in the micrometre scale (the size ratio of a system to its component is typically 10:1)

  17. KHIC's experience in the design and fabrication of nuclear components

    International Nuclear Information System (INIS)

    Suh, S.-C.

    1992-01-01

    Since 1980, Korea Heavy Industries ampersand Construction Company, Ltd. (KHIC) has specialized in the design and equipment supply for nuclear power facilities in Korea. In April 1987, KHIC became the prime contractor for the construction of Yonggwang 3 ampersand 4 (YGN 3 ampersand 4) nuclear power project. Accordingly, KHIC's technological self-reliance capability for the manufacturing processes of the primary system equipment and components has increased from 18% during the initial stage of Yonggwang 1 ampersand 2 (YGN 1 ampersand 2) project to 63% for YGN 3 ampersand 4 project. Self-reliance capability for the secondary system equipment and components has increased from 28% to 84% during the same period of time as well. The ultimate goal is to achieve complete and total assurance that our products are of the finest quality in the nuclear industry in the world market. Henceforth, we will be able to guarantee complete customer satisfaction and reliability of our products with safety assurance and leading edge technology

  18. Fabrication of beam diagnostic components for Superconducting Cyclotron at Kolkata

    International Nuclear Information System (INIS)

    Roy, S.; Bhattacharya, S.; Das, T.; Bhattacharyya, T.K.; Pal, S.; Pal, G.; Mallik, C.; Bhandari, R.K.

    2009-01-01

    The viewer probe and main probe are used for determining the position and current of charged particles as it is accelerated inside the superconducting cyclotron. The viewer probe is used to visually observe the shape of the charged particle beam inside the cyclotron with the help of a borescope. The main probe measures the distribution of charged particles. The viewer probe and main probe are bellow sealed. They can be positioned with an accuracy of 0.5 mm at different radii within the superconducting cyclotron. M9 slit is placed after the exit flange of the cyclotron. It determines the position of the beam leaving the cyclotron. The beam line has slits, faraday cup, beam viewers, collimators, etc. for beam diagnostics. This paper presents the mechanical design and details of beam diagnostic components. (author)

  19. Design and fabrication of a eccentric wheels based motorised alignment mechanism for cylindrical accelerator components

    International Nuclear Information System (INIS)

    Mundra, G.; Jain, V.; Karmarkar, Mangesh; Kotaiah, S.

    2006-01-01

    Precision alignment mechanisms with long term stability are required for accelerator components. For some of the components motorised and remotely operable alignment mechanism are required. An eccentric wheel mechanism based alignment system is very much suitable for such application. One such alignment system is designed, a prototype is machined/fabricated for SFDTL type accelerating structure and preliminary trial experiments have been done. (author)

  20. Aspects for selection of materials and fabrication processes for nuclear component manufacturing

    International Nuclear Information System (INIS)

    Pernstich, K.

    1980-01-01

    For components of the Nuclear steam supply System of Light Water Reactors an extremely high safety standard is required. These requirements only can be met by adequate selection of materials and fabrication processes and their proper application in combination with strict quality assurance and control measurements. A general overview of the basic aspects to be considered in this connection is presented together with an indication of the present state of art for the main materials and fabrication processes. (author) [pt

  1. THE STUDY OF THE CHARACTERIZATION INDICES OF FABRICS BY PRINCIPAL COMPONENT ANALYSIS METHOD

    Directory of Open Access Journals (Sweden)

    HRISTIAN Liliana

    2017-05-01

    Full Text Available The paper was pursued to prioritize the worsted fabrics type, for the manufacture of outerwear products by characterization indeces of fabrics, using the mathematical model of Principal Component Analysis (PCA. There are a number of variables with a certain influence on the quality of fabrics, but some of these variables are more important than others, so it is useful to identify those variables to a better understanding the factors which can lead the improving of the fabrics quality. A solution to this problem can be the application of a method of factorial analysis, the so-called Principal Component Analysis, with the final goal of establishing and analyzing those variables which influence in a significant manner the internal structure of combed wool fabrics according to armire type. By applying PCA it is obtained a small number of the linear combinations (principal components from a set of variables, describing the internal structure of the fabrics, which can hold as much information as possible from the original variables. Data analysis is an important initial step in decision making, allowing identification of the causes that lead to a decision- making situations. Thus it is the action of transforming the initial data in order to extract useful information and to facilitate reaching the conclusions. The process of data analysis can be defined as a sequence of steps aimed at formulating hypotheses, collecting primary information and validation, the construction of the mathematical model describing this phenomenon and reaching these conclusions about the behavior of this model.

  2. HRP facility for fabrication of ITER vertical target divertor full scale plasma facing units

    International Nuclear Information System (INIS)

    Visca, Eliseo; Roccella, S.; Candura, D.; Palermo, M.; Rossi, P.; Pizzuto, A.; Sanguinetti, G.P.; Mancini, A.; Verdini, L.; Cacciotti, E.; Cerri, V.; Mugnaini, G.; Reale, A.; Giacomi, G.

    2015-01-01

    Highlights: • R&D activities for the manufacturing of ITER divertor high heat flux plasma-facing components (HHFC). • ENEA and Ansaldo have jointly manufactured several actively cooled monoblock mock-ups and prototypical components. • ENEA and ANSALDO NUCLEARE jointly participate to the European program for the qualification of the manufacturing technology for the ITER divertor IVT. • Successful manufacturing by HRP (Hot Radial Pressing) of first full-scale full-W armored IVT qualification prototype. - Abstract: ENEA and Ansaldo Nucleare S.p.A. (ANN) have being deeply involved in the European development activities for the manufacturing of the ITER Divertor Inner Vertical Target (IVT) plasma-facing components. During normal operation the heat flux deposited on the bottom segment of divertor is 5–10 MW/m 2 but the capability to remove up to 20 MW/m 2 during transient events of 10 s must also be demonstrated. In order to fulfill ITER requirements, ENEA has set up and widely tested a manufacturing process, named Hot Radial Pressing (HRP). The last challenge is now to fabricate full-scale prototypes of the IVT, aimed to be qualified for the next step, i.e. the series production. On the basis of the experience of manufacturing hundreds of small mock-ups, ENEA designed and installed a new suitable HRP facility. The objective of getting a final shaped plasma facing unit (PFU) that satisfies these requirements is an ambitious target because tolerances set by ITER/F4E are very tight. The setting-up of the equipment started with the fabrication of full scale and representative ‘dummies’ in which stainless steel instead of CFC or W was used for monoblocks. The results confirmed that dimensions were compliant with the required tolerances. The paper reports a brief description of the innovative HRP equipment and the dimensional check results after HRP of the first full-scale full-W PFU.

  3. HRP facility for fabrication of ITER vertical target divertor full scale plasma facing units

    Energy Technology Data Exchange (ETDEWEB)

    Visca, Eliseo, E-mail: eliseo.visca@enea.it [Unità Tecnica Fusione, ENEA C. R. Frascati, via E. Fermi 45, IT-00044 Frascati (Roma) (Italy); Roccella, S. [Unità Tecnica Fusione, ENEA C. R. Frascati, via E. Fermi 45, IT-00044 Frascati (Roma) (Italy); Candura, D.; Palermo, M. [Ansaldo Nucleare S.p.A., Corso Perrone 25, IT-16152 Genova (Italy); Rossi, P.; Pizzuto, A. [Unità Tecnica Fusione, ENEA C. R. Frascati, via E. Fermi 45, IT-00044 Frascati (Roma) (Italy); Sanguinetti, G.P. [Ansaldo Nucleare S.p.A., Corso Perrone 25, IT-16152 Genova (Italy); Mancini, A.; Verdini, L.; Cacciotti, E.; Cerri, V.; Mugnaini, G.; Reale, A.; Giacomi, G. [Unità Tecnica Fusione, ENEA C. R. Frascati, via E. Fermi 45, IT-00044 Frascati (Roma) (Italy)

    2015-10-15

    Highlights: • R&D activities for the manufacturing of ITER divertor high heat flux plasma-facing components (HHFC). • ENEA and Ansaldo have jointly manufactured several actively cooled monoblock mock-ups and prototypical components. • ENEA and ANSALDO NUCLEARE jointly participate to the European program for the qualification of the manufacturing technology for the ITER divertor IVT. • Successful manufacturing by HRP (Hot Radial Pressing) of first full-scale full-W armored IVT qualification prototype. - Abstract: ENEA and Ansaldo Nucleare S.p.A. (ANN) have being deeply involved in the European development activities for the manufacturing of the ITER Divertor Inner Vertical Target (IVT) plasma-facing components. During normal operation the heat flux deposited on the bottom segment of divertor is 5–10 MW/m{sup 2} but the capability to remove up to 20 MW/m{sup 2} during transient events of 10 s must also be demonstrated. In order to fulfill ITER requirements, ENEA has set up and widely tested a manufacturing process, named Hot Radial Pressing (HRP). The last challenge is now to fabricate full-scale prototypes of the IVT, aimed to be qualified for the next step, i.e. the series production. On the basis of the experience of manufacturing hundreds of small mock-ups, ENEA designed and installed a new suitable HRP facility. The objective of getting a final shaped plasma facing unit (PFU) that satisfies these requirements is an ambitious target because tolerances set by ITER/F4E are very tight. The setting-up of the equipment started with the fabrication of full scale and representative ‘dummies’ in which stainless steel instead of CFC or W was used for monoblocks. The results confirmed that dimensions were compliant with the required tolerances. The paper reports a brief description of the innovative HRP equipment and the dimensional check results after HRP of the first full-scale full-W PFU.

  4. Development of technology on natural flaw fabrication and precise diagnosis for the major components in NPPs

    International Nuclear Information System (INIS)

    Han, Jung Ho; Choi, Myung Sik; Lee, Doek Hyun; Hur, Do Haeng

    2002-01-01

    The objective of this research is to develop a fabrication technology of natural flaw specimen of major components in NPPs and a technology of precise diagnosis for failure and degradation of components using natural flaw specimen. 1) Successful development of the natural flaw fabrication technology of SG tube 2) Evaluation of ECT signal and development of precise diagnosis using natural flaws. - Determination of length, depth, width, and multiplicity of fabricated natural flaws. - Informations about detectability and accuracy of ECT evaluation on various kinds of defects are collected when the combination of probe and frequency is changed. - An advanced technology for precise ECT evaluation is established. 3) Application of precise ECT diagnosis to failure analysis of SG tube in operation. - Fretting wear of KSNP SG. - ODSCC at tube expanded region of KSNP SG. - Determination of through/non-through wall of axial crack

  5. Nonspecific Organelle-Targeting Strategy with Core-Shell Nanoparticles of Varied Lipid Components/Ratios.

    Science.gov (United States)

    Zhang, Lu; Sun, Jiashu; Wang, Yilian; Wang, Jiancheng; Shi, Xinghua; Hu, Guoqing

    2016-07-19

    We report a nonspecific organelle-targeting strategy through one-step microfluidic fabrication and screening of a library of surface charge- and lipid components/ratios-varied lipid shell-polymer core nanoparticles. Different from the common strategy relying on the use of organelle-targeted moieties conjugated onto the surface of nanoparticles, here, we program the distribution of hybrid nanoparticles in lysosomes or mitochondria by tuning the lipid components/ratios in shell. Hybrid nanoparticles with 60% 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) and 20% 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) can intracellularly target mitochondria in both in vitro and in vivo models. While replacing DOPE with the same amount of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), the nanoparticles do not show mitochondrial targeting, indicating an incremental effect of cationic and fusogenic lipids on lysosomal escape which is further studied by molecular dynamics simulations. This work unveils the lipid-regulated subcellular distribution of hybrid nanoparticles in which target moieties and complex synthetic steps are avoided.

  6. The fabrication techniques of Z-pinch targets. Techniques of fabricating self-adapted Z-pinch wire-arrays

    International Nuclear Information System (INIS)

    Qiu Longhui; Wei Yun; Liu Debin; Sun Zuoke; Yuan Yuping

    2002-01-01

    In order to fabricate wire arrays for use in the Z-pinch physical experiments, the fabrication techniques are investigated as follow: Thickness of about 1-1.5 μm of gold is electroplated on the surface of ultra-fine tungsten wires. Fibers of deuterated-polystyrene (DPS) with diameters from 30 to 100 microns are made from molten DPS. And two kinds of planar wire-arrays and four types of annular wire-arrays are designed, which are able to adapt to the variation of the distance between the cathode and anode inside the target chamber. Furthermore, wire-arrays with diameters form 5-24 μm are fabricated with tungsten wires, respectively. The on-site test shows that the wire-arrays can self-adapt to the distance changes perfectly

  7. Double-shell inertial confinement fusion target fabrication

    International Nuclear Information System (INIS)

    Hatcher, C.W.; Lorensen, L.E.; Weinstein, B.W.

    1980-01-01

    First generation hemishells, from which spherical shells are constructed, were fabricated by micromachining coated mandrels and by molding. The remachining of coated mandrels are described in detail. Techniques were developed for coating the microsized mandrels with polymeric and metallic materials by methods including conformal coating, vapor deposition, plasma polymerization and thermoforming. Micropositioning equipment and bonding techniques have also been developed to assemble the hemishells about a fuel pellet maintaining a spherical concentricity of better than 2 μm and voids in the hemishell bonding line of a few hundred angstroms or less

  8. Rapid fabrication and characterization of sine wave targets

    International Nuclear Information System (INIS)

    Day, R.D.; Armijo, E.; Gobby, P.; Hatch, D.; Rivera, G.; Salzer, L.; Townsend, J.

    1997-01-01

    The effect of surface perturbations on Inertial Confinement Fusion target performance is currently being researched at Los Alamos National Laboratory (LANL). These perturbations can cause hydrodynamic instabilities which in turn reduce the targets' yield. To systematically measure the growth of these instabilities requires targets to be produced which have perturbations of a known amplitude and spatial frequency. The authors have recently assembled hardware onto one of their diamond turning lathes which enables them to machine and measure these sine waves in about 15 minutes. This is a significant reduction in time from the two and one half hours required by the previous method. This paper discusses the hardware, how it works, and how well the system is working for them to produce these targets

  9. Fabrication of 94Zr thin target for RDM lifetime measurement

    International Nuclear Information System (INIS)

    Gupta, Chandan Kumar; Rohilla, Aman; Chamoli, S.K.; Abhilash, S.R.; Kabiraj, D.; Singh, R.P.; Mehta, D.

    2013-01-01

    The aim of the activity was to make a thin target of isotopically enriched 94 Zr for lifetime measurement experiment to be done with the plunger setup at the Inter University Accelerator Center (IUAC) Delhi

  10. Effect of components (polymer, plasticizer and solvent as a variable in fabrication of diclofenac transdermal patch

    Directory of Open Access Journals (Sweden)

    Chetna Modi

    2012-01-01

    Full Text Available Transdermal drug delivery influence consumer acceptance and marked increase in bioavailability of some drugs which undergoes hepatic first-pass metabolism. Fabrication of transdermal patch requires lots of attention regarding the amount of components used for it. Because of varied nature of polymer and plasticizer, transdermal patches have different properties and different drug release. This study is on the basis to evaluate the amount to be needed for fabrication of diclofenac transdermal patch. Study shows that Hydroxy Propyl Methyl Cellulose has great influence on transdermal patch, if it is used alone in combination with glycerin or PEG-4000 plasticizer.

  11. Target fabrication using laser and spark erosion machining

    International Nuclear Information System (INIS)

    Clement, X.; Coudeville, A.; Eyharts, P.; Perrine , J.P.; Rouillard, R.

    1981-11-01

    Lasers and E.D.M. (electrical discharge machining) are both extremely useful tools for machining the small targets needed in inertial confinement studies. Lasers are currently used in a wide range of target problems and it appears that E.D.M. has a still wider range of applications for plane and spherical targets. The problems of material deformation and tool breaking are practically eliminated as the electrode and the machined part are not in mechanical contact. In comparison with laser micromachining E.D.M. offers: larger versatility with the possibility of new developments and applications; higher production speed for thin conducting materials; lower initial and operating costs; the processes are well controlled, reproducible and can be easily automated; the operation is safe without the dangers associted with lasers

  12. Characterization of titanium aluminide alloy components fabricated by additive manufacturing using electron beam melting

    International Nuclear Information System (INIS)

    Murr, L.E.; Gaytan, S.M.; Ceylan, A.; Martinez, E.; Martinez, J.L.; Hernandez, D.H.; Machado, B.I.; Ramirez, D.A.; Medina, F.; Collins, S.; Wicker, R.B.

    2010-01-01

    Intermetallic, γ-TiAl, equiaxed, small-grain (∼2 μm) structures with lamellar γ/α 2 -Ti 3 Al colonies with average spacing of 0.6 μm have been fabricated by additive manufacturing using electron beam melting (EBM) of precursor, atomized powder. The residual microindentation (Vickers) hardness (HV) averaged 4.1 GPa, corresponding to a nominal yield strength of ∼1.4 GPa (∼HV/3), and a specific yield strength of 0.37 GPa cm 3 g -1 (for a density of 3.76 g cm -3 ), in contrast to 0.27 GPa cm 3 g -1 for EBM-fabricated Ti-6Al-4V components. These results demonstrate the potential to fabricate near net shape and complex titanium aluminide products directly using EBM technology in important aerospace and automotive applications.

  13. Fabrication of cryogenic inertial-confinement-fusion targets using target free-fall technique. Report No. 2-82

    International Nuclear Information System (INIS)

    Kim, K.; Murphy, M.J.

    1982-04-01

    Techniques for fabricating cryogenic inertial confinement fusion targets (i.e., spherical shells containing a uniform layer of DT ice) are investigated using target free-fall concept. Detection and characterization of the moving targets are effected by optoelectronic means, of which the principal is an RF ac-interferometer. This interferometer system demonstrates, for the first time, the speed capabilities of the phase-modulation ac-interferometry. New techiques developed for handling, holding, launching, and transporting targets are also described. Results obtained at both room and cryogenic temperatures are presented

  14. Materials processing in space: ICF target fabrication implications

    International Nuclear Information System (INIS)

    Hendricks, C.D.

    1982-01-01

    During the last quarter of 1982, the Novette laser will become operational at Lawrence Livermore National Laboratory. The primary characteristics of the Novette laser are shown. In many ways, the new laser will serve as a proving ground and test bed for the Nova laser which is also under construction and should be operational in early 1985. Tables provide the Nova operational characteristics. The advent of the two new lasers, Novette and Nova, will make it possible to study many new and exciting aspects of laser-target interactions and of many implosion physics experiments which have previously not been possible. Some of the most interesting and exciting work will be the exploration of the parameters critical to the ignition of a significant thermonuclear burn in the deuterium-tritium fuel in the targets

  15. Fabrication of a tantalum-clad tungsten target for KENS

    International Nuclear Information System (INIS)

    Kawai, Masayoshi; Kikuchi, Kenji; Kurishita, Hiroaki; Li, J.-F.; Furusaka, Michihiro

    2001-01-01

    Since the cold neutron source intensity of KENS (the spallation neutron source at High Energy Accelerator Research Organization) was decreased into about a third of the designed value because a cadmium liner at the cold neutron source deformed and obstructed the neutron beam line, the target-moderator-and-reflector assembly (TMRA) has been replaced by a new one aimed at improving the neutron performance and recovering the cold neutron source. The tantalum target has also been replaced by a tantalum-clad tungsten one. In order to bond the tantalum-clad with the tungsten block, a hot isostatic press (HIP) process was applied and optimized. It was found that gaseous interstitial impurity elements severely attacked tantalum and embrittled, and that the getter materials such as zirconium and tantalum were effective to reduce the embrittlement

  16. Advanced targeted monitoring of high temperature components in power plants

    Energy Technology Data Exchange (ETDEWEB)

    Roos, E.; Maile, K.; Jovanovic, A. [MPA Stuttgart (Germany)

    1998-12-31

    The article presents the idea of targeted monitoring of high-temperature pressurized components in fossil-fueled power plants, implemented within a modular software system and using, in addition to pressure and temperature data, also displacement and strain measurement data. The concept has been implemented as a part of a more complex company-oriented Internet/Intranet system of MPA Stuttgart (ALIAS). ALIAS enables to combine smoothly the monitoring results with those of the off-line analysis, e. g. sensitivity analyses, comparison with preceding experience (case studies), literature search, search in material databases -(experimental and standard data), nonlinear FE-analysis, etc. The concept and the system have been implemented in real plant conditions several power plants in Germany and Europe: one of these applications and its results are described more in detail in the presentation. (orig.) 9 refs.

  17. Advanced targeted monitoring of high temperature components in power plants

    Energy Technology Data Exchange (ETDEWEB)

    Roos, E; Maile, K; Jovanovic, A [MPA Stuttgart (Germany)

    1999-12-31

    The article presents the idea of targeted monitoring of high-temperature pressurized components in fossil-fueled power plants, implemented within a modular software system and using, in addition to pressure and temperature data, also displacement and strain measurement data. The concept has been implemented as a part of a more complex company-oriented Internet/Intranet system of MPA Stuttgart (ALIAS). ALIAS enables to combine smoothly the monitoring results with those of the off-line analysis, e. g. sensitivity analyses, comparison with preceding experience (case studies), literature search, search in material databases -(experimental and standard data), nonlinear FE-analysis, etc. The concept and the system have been implemented in real plant conditions several power plants in Germany and Europe: one of these applications and its results are described more in detail in the presentation. (orig.) 9 refs.

  18. Technologies for ITER divertor vertical target plasma facing components

    International Nuclear Information System (INIS)

    Schlosser, J.; Escourbiac, F.; Merola, M.; Fouquet, S.; Bayetti, P.; Cordier, J.J.; Grosman, A.; Missirlian, M.; Tivey, R.; Roedig, M.

    2005-01-01

    The ITER divertor vertical target has to sustain heat fluxes up to 20 MW m -2 . The concept developed for this plasma facing component working at steady state is based on carbon fibre composite armour for the lower straight part and tungsten for the curved upper part. The main challenges involved in the use of such components include the removal of the high heat fluxes deposited and mechanically and thermally joining the armour to the metallic heat sink, despite the mismatch in the thermal expansions. Two solutions based on the use of a CuCrZr hardened copper alloy and an active metal casting (AMC (registered) ) process were investigated during the ITER EDA phase: the first one called 'flat tile geometry' was mainly developed for the Tore Supra pumped limiter, the second one called 'monoblock geometry' was developed by the EU Participating Team for the ITER project. This paper presents a review of these two solutions and analyses their assets and drawbacks: pressure drop, critical heat flux, surface temperature and expected behaviour during operation, risks during the manufacture, control of the armour defects during the manufacture and at the reception, and the possibility of repairing defective tiles

  19. Fabrication and Evaluation of Tinidazole Microbeads for Colon Targeting

    Directory of Open Access Journals (Sweden)

    Amit K. Pandey

    2012-05-01

    Full Text Available Objective: The purpose of present investigation was to develop and evaluate multiparticulate system exploiting pH-sensitive property and specific biodegradability of calcium alginate microbeads, for colon- targeted delivery of Tinidazole for the treatment of amoebic colitis. Methods: Calcium alginate beads containing Tinidazole were prepared by ionotropic gelation technique followed by coating with Eudragit S100 using solvent evaporation method to obtain pH sensitive microbeads. Various formulation parameters were optimized which included concentration of sodium alginate (2% w/v, curing time (20 min and concentration of pectin (1% w/ v. All the formulations were evaluated for surface morphology, particle size analysis, entrapment efficiency and in-vitro drug release in conditions simulating colonic fluid in the presence of rat caecal (2% w/v content. Results: The average size of beads of optimized formulation (FT4 was found to be 998.73依5.12 毺 m with entrapment efficiency of 87.28依2.19 %. The invitro release of Eudragit S100 coated beads in presence of rat caecal content was found to be 70.73%依1.91% in 24 hours. Data of in-vitro release was fitted into Higuchi kinetics and Korsmeyer Peppas equation to explain release profile. The optimized formulation (FT4 showed zero order release. Conclusions: It is concluded that calcium alginate microbeads are the potential system for colon delivery of Tinidazole for chemotherapy of amoebic infection.

  20. Fabrication technology for a series of cylindrical thin-wall cavity targets

    CERN Document Server

    Zheng Yong; Sun Zu Oke; Wang Ming Da; Zhou La; Zhou Zhi Yun

    2002-01-01

    Cylindrical thin-wall cavity targets have been fabricated to study the behavior of superthermal electrons and their effects on inertial confinement fusion (ICF). Self-supporting cavity targets having adjustable, uniform wall thickness, and low surface roughness were required. This required production of high-quality mandrels, coating them by sputtering or electroplating, developing techniques for measurement of wall thickness and other cavity parameters, improving the uniformity of rotation of the mandrels, and preventing damage to the targets during removal from the mandrels. Details of the fabrication process are presented. Experimental results from the use of these targets are presented. These results, in good agreement with simulations, indicate that the use of thin-wall cavity targets is an effective method for studying superthermal electrons in ICF.

  1. Structural Component Fabrication and Characterization of Advanced Radiation Resistant ODS Steel for Next Generation Nuclear Systems

    International Nuclear Information System (INIS)

    Noh, Sang Hoon; Kim, Young Chun; Jin, Hyun Ju; Choi, Byoung Kwon; Kang, Suk Hoon; Kim, Tae Kyu

    2016-01-01

    In a sodium-cooled fast reactor (SFR), the coolant outlet temperature and peak temperature of the fuel cladding tube will be about 545 .deg. C and 700 .deg. C with 250 dpa of a very high neutron dose rate. To realize this system, it is necessary to develop an advanced structural material having high creep and irradiation resistance at high temperatures. Austenitic stainless steel may be one of the candidates because of good strength and corrosion resistance at the high temperatures, however irradiation swelling severely occurred to 120dpa at high temperatures and this eventually leads to a decrease of the mechanical properties and dimensional stability. Advanced radiation resistant ODS steel (ARROS) has been newly developed for the in-core structural components in SFR, which has very attractive microstructures to achieve both superior creep and radiation resistances at high temperatures [4]. Nevertheless, the use of ARROS as a structural material essentially requires the fabrication technology development for component parts such as sheet, plate and tube. In this study, plates and tubes were tentatively fabricated with a newly developed alloy, ARROS. Microstructures as well as mechanical properties were also investigated to determine the optimized condition of the fabrication processes.

  2. Complete fabrication of target experimental chamber and implement initial target diagnostics to be used for the first target experiments in NDCX-1

    International Nuclear Information System (INIS)

    Bieniosek, F.M.; Bieniosek, F.M.; Dickinson, M.R.; Henestroza, E.; Katayanagi, T.; Jung, J.Y.; Lee, C.W.; Leitner, M.; Ni, P.; Roy, P.; Seidl, P.; Waldron, W.; Welch, D.

    2008-01-01

    The Heavy Ion Fusion Science Virtual National Laboratory (HIFS-VNL) has completed the fabrication of a new experimental target chamber facility for future Warm Dense Matter (WDM) experiments, and implemented initial target diagnostics to be used for the first target experiments in NDCX-1. The target chamber has been installed on the NDCX-I beamline. This achievement provides to the HIFS-VNL unique and state-of-the-art experimental capabilities in preparation for the planned target heating experiments using intense heavy ion beams

  3. Investigation on fabrication and positioning of cryogenic shell laser fusion targets. Annual report, October 1, 1977--November 30, 1978

    International Nuclear Information System (INIS)

    Kim, K.

    1978-01-01

    The research has been directed toward fabrication and positioning of cryogenic shell laser fusion targets, with particular emphasis on the development of a scheme which would allow for continuous fabrication, inspection, and delivery of the targets. Specifically, progress has been made in each of the following areas: (1) fabrication of a uniform layer of solid DT inside a glass microshell using a combination of helium gas jets and a heater wire; (2) levitation-freezing of a DT-filled glass microshell as a method for fabricating and positioning a cryogenic shell target; (3) a target fabrication system intended for continuous fabrication, inspection, and delivery of cryogenic targets; and (4) development of diagnostics for inspection, recording, and analysis of a solid DT layer inside a glass microshell, and for observing the parameters controlling the target freezing process

  4. Fabrication of nuclear ship reactor MRX model and study on inspection and maintenance of components

    International Nuclear Information System (INIS)

    Kasahara, Yoshiyuki; Nakazawa, Toshio; Kusunoki, Tsuyoshi; Takahashi, Hiroki; Yoritsune, Tsutomu.

    1997-10-01

    The MRX (Marine Reactor X) is an integral type small reactor adopting passive safety systems. As for an integral type reactor, primary system components are installed in the reactor vessel. It is therefor important to establish the appropriate procedure for construction, inspection and maintenance, dismauntling, etc., for all components in the reactor vessel as well as in the reactor containment, because inspection space is limited. To study these subjects, a one-fifth model of the MRX was fabricated and operation capabilities were studied. As a result of studies, the following results are obtained. (1) Manufacturing and installing problems of the reactor pressure vessel, the containment vessel and internal components are basically not abserved. (2) Heat transfer tube structures of the steam generator and the heat exchangers of emergency decay heat removal system and containment water cooler were not seen of any problem for fabrication. However, due consideration is required in the detailed design of supports of heat transfer tubes. (3) Further studies should be needed for designs of flange penetrations and leak countermeasures for pipes instrument cables. (4) Arrangements of equipments in the containment should be taken in consideration in detail because the space is narrow. (5) Further discussion is required for installation methods of instruments and cables. (author)

  5. Fabrication of high-alloy powders consisting of spherical particles from ultradispersed components

    Science.gov (United States)

    Samokhin, A. V.; Fadeev, A. A.; Sinayskiy, M. A.; Alekseev, N. V.; Tsvetkov, Yu. V.; Arzhatkina, O. A.

    2017-07-01

    It is shown that powders of a model high alloy consisting of spherical particles 25-50 μm in size can be synthesized from a starting ultradispersed powder, which is made of a mixture of the alloy components and is fabricated by the magnesiothermal reduction of metal chlorides in the potassium chloride melt. The synthesis includes the stages of microgranulation of an ultradispersed powder, heat treatment of microgranules, classification of the microgranules with the separation of microgranule fraction of 25-50 μm, spheroidization of the separated fraction in a thermal plasma flow, and classification with the separation of a fraction of micro- and submicrometer-sized particles.

  6. Method and alloys for fabricating wrought components for high-temperature gas-cooled reactors

    International Nuclear Information System (INIS)

    Thompson, L.D.; Johnson, W.R.

    1983-01-01

    Wrought, nickel-based alloys, suitable for components of a high-temperature gas-cooled reactor exhibit strength and excellent resistance to carburization at elevated temperatures and include aluminum and titanium in amounts and ratios to promote the growth of carburization resistant films while preserving the wrought character of the alloys. These alloys also include substantial amounts of molybdenum and/or tungsten as solid-solution strengtheners. Chromium may be included in concentrations less than 10% to assist in fabrication. Minor amounts of carbon and one or more carbide-forming metals also contribute to high-temperature strength. The range of compositions of these alloys is given. (author)

  7. Fused Filament Fabrication of Prosthetic Components for Trans-Humeral Upper Limb Prosthetics

    Science.gov (United States)

    Lathers, Steven M.

    Presented below is the design and fabrication of prosthetic components consisting of an attachment, tactile sensing, and actuator systems with Fused Filament Fabrication (FFF) technique. The attachment system is a thermoplastic osseointegrated upper limb prosthesis for average adult trans-humeral amputation with mechanical properties greater than upper limb skeletal bone. The prosthetic designed has: a one-step surgical process, large cavities for bone tissue ingrowth, uses a material that has an elastic modulus less than skeletal bone, and can be fabricated on one system. FFF osseointegration screw is an improvement upon the current two-part osseointegrated prosthetics that are composed of a fixture and abutment. The current prosthetic design requires two invasive surgeries for implantation and are made of titanium, which has an elastic modulus greater than bone. An elastic modulus greater than bone causes stress shielding and overtime can cause loosening of the prosthetic. The tactile sensor is a thermoplastic piezo-resistive sensor for daily activities for a prosthetic's feedback system. The tactile sensor is manufactured from a low elastic modulus composite comprising of a compressible thermoplastic elastomer and conductive carbon. Carbon is in graphite form and added in high filler ratios. The printed sensors were compared to sensors that were fabricated in a gravity mold to highlight the difference in FFF sensors to molded sensors. The 3D printed tactile sensor has a thickness and feel similar to human skin, has a simple fabrication technique, can detect forces needed for daily activities, and can be manufactured in to user specific geometries. Lastly, a biomimicking skeletal muscle actuator for prosthetics was developed. The actuator developed is manufactured with Fuse Filament Fabrication using a shape memory polymer composite that has non-linear contractile and passive forces, contractile forces and strains comparable to mammalian skeletal muscle, reaction

  8. Field analysis and enhancement of multi-pole magnetic components fabricated on printed circuit board

    International Nuclear Information System (INIS)

    Chiu, K.-C.; Chen, C.-S.

    2007-01-01

    A multi-pole magnetic component magnetized with a fine magnetic pole pitch of less than 1 mm is very difficult to achieve by using traditional methods. Moreover, it requires a precise mechanical process and a complicated magnetization system. Different fine magnetic pole pitches of 300, 350 and 400 μm have been accomplished on 9-pole magnetic components through the printed circuit board (PCB) manufacturing technology. Additionally, another fine magnetic pole pitch of 500 μm was also fabricated on a dual-layered (DL) wire circuit structure to investigate the field enhancement. After measurements, a gain factor of 1.37 was obtained in the field strength. The field variations among different magnetic pole pitches were analyzed in this paper

  9. Pulsed TIG welding in the fabrication of nuclear components and structures

    International Nuclear Information System (INIS)

    Lucas, W.; Males, B.O.

    1979-01-01

    TIG welding is an important welding technique in nuclear plant fabrication for the welding of critical components and structures where a high level of weld integrity is demanded. Whilst the process is ideally suited to precision welding, since the arc is a small intense heat source, it has proved to be somewhat intolerant to production variations in 'difficult' applications, such as tube to tube plate welding and orbital tube welding with tube in the fixed position. Whilst the problems directly associated with this intolerance (of the welding process) are less frequently observed when used manually, difficulties are experienced in fully mechanised welding operations particularly when welding to a relatively rigid approved procedure. Pulsing of the welding current was developed as a technique to achieve greater control of the behaviour of the weld pool. Instead of moving the weld pool in a continuous motion around the joint, welding was conducted intermittently in the form of overlapping spots. This technique, which offers significant advantages over continuous current welding has been exploited in nuclear fabrication for welding those components which demand a high level of weld quality. In this paper, the essential features of this technique are described and, in indicating its advantages, examples have been drawn from recent experiences on the welding of two types of joint for the Advanced Gas Cooled Reactor, a tube sheet and a butt joint in the G Position. (author)

  10. Concentrating Solar Power Central Receiver Panel Component Fabrication and Testing FINAL REPORT

    Energy Technology Data Exchange (ETDEWEB)

    McDowell, Michael W [Pratt & Whitney Rocketdyne; Miner, Kris [Pratt & Whitney Rocketdyne

    2013-03-30

    The objective of this project is to complete a design of an advanced concentrated solar panel and demonstrate the manufacturability of key components. Then confirm the operation of the key components under prototypic solar flux conditions. This work is an important step in reducing the levelized cost of energy (LCOE) from a central receiver solar power plant. The key technical risk to building larger power towers is building the larger receiver systems. Therefore, this proposed technology project includes the design of an advanced molten salt prototypic sub-scale receiver panel that can be utilized into a large receiver system. Then complete the fabrication and testing of key components of the receive design that will be used to validate the design. This project shall have a significant impact on solar thermal power plant design. Receiver panels of suitable size for utility scale plants are a key element to a solar power tower plant. Many subtle and complex manufacturing processes are involved in producing a reliable, robust receiver panel. Given the substantial size difference between receiver panels manufactured in the past and those needed for large plant designs, the manufacture and demonstration on prototype receiver panel components with representative features of a full-sized panel will be important to improving the build process for commercial success. Given the thermal flux limitations of the test facility, the panel components cannot be rendered full size. Significance changes occurred in the projects technical strategies from project initiation to the accomplishments described herein. The initial strategy was to define cost improvements for the receiver, design and build a scale prototype receiver and test, on sun, with a molten salt heat transport system. DOE had committed to constructing a molten salt heat transport loop to support receiver testing at the top of the NSTTF tower. Because of funding constraints this did not happen. A subsequent plan to

  11. Process for the fabrication of aluminum metallized pyrolytic graphite sputtering targets

    Science.gov (United States)

    Makowiecki, Daniel M.; Ramsey, Philip B.; Juntz, Robert S.

    1995-01-01

    An improved method for fabricating pyrolytic graphite sputtering targets with superior heat transfer ability, longer life, and maximum energy transmission. Anisotropic pyrolytic graphite is contoured and/or segmented to match the erosion profile of the sputter target and then oriented such that the graphite's high thermal conductivity planes are in maximum contact with a thermally conductive metal backing. The graphite contact surface is metallized, using high rate physical vapor deposition (HRPVD), with an aluminum coating and the thermally conductive metal backing is joined to the metallized graphite target by one of four low-temperature bonding methods; liquid-metal casting, powder metallurgy compaction, eutectic brazing, and laser welding.

  12. Design and fabrication of foam-insulated cryogenic target for wet-wall laser fusion reactor

    International Nuclear Information System (INIS)

    Norimatsu, T.; Takeda, T.; Nagai, K.; Mima, K.; Yamanaka, T.

    2003-01-01

    A foam insulated cryogenic target was proposed for use in a future laser fusion reactor with a wet wall. This scheme can protect the solid DT layer from melting due to surface heating by adsorption of metal vapor without significant reduction in the target gain. Design spaces for the injection velocity and the acceptable vapor pressure in the reactor are discussed. Basic technology to fabricate such structure was demonstrated by emulsion process. Concept of a cryogenic fast-ignition target with a gold guiding cone was proposed together with direct injection filling of liquid DT. (author)

  13. PDSM characterization for fabrication of free-space OXC optical components

    Science.gov (United States)

    Argueta, Victor; Fitzpatrick, Brianna

    2017-11-01

    In 2007 Dr Khine et al published a paper where they presented a technique using thermoplastics and PDMS to create microfluidic patterns1. Their technique involves printing a pattern in a polystyrene sheet using a laser printer. Once the pattern is transfer the polystyrene sheets they are heated to reduce their size. By printing the same pattern of the plastic sheets before heating, it is possible to control the height up to 80 μm and the width as thin as 65 μm1, 2. This technique is attractive to be used in optical fabrication due to its versatility, low cost and fast prototyping. However, in order to fabricate optical systems, we will need to control the refractive index of PDMS to allow design of basic optical components like waveguides, beam splitter, or diffuse reflectors; or more complex structures like interferometers, optical microfluidic lab-on-chip, micro-lens arrays. Several techniques exist to control the refractive index for PDMS either by controlling the curing temperature, the ratio between the base and curing agent, or by curing using UV light3-5. In this paper, we present the changes on refractive index by changing the curing temperature for different base/reaction agent ratios. We then apply these results to fabricate an optical component for a free-space optical cross-connect (OXC). Optical cross-connects are an important network element for constructing the next generation of optical networks, where provisioning (reconfiguration), scalability, and fast restoration will be needed6-8. The main attraction of all-optical switching is that it enables routing of optical data signals without the need for conversion to electrical signals, and therefore, is independent of data rate and data protocols. We have proposed previously9, 11 a new approach for an OXC. Our architecture is a free-space 3-D while still using digital MEMS. Our system is based on the optical White cell12, which consists of three spherical mirrors among which light can circulate. In

  14. Fabrication of 94Zr thin target for recoil distance doppler shift method of lifetime measurement

    International Nuclear Information System (INIS)

    Gupta, C.K.; Rohilla, Aman; Abhilash, S.R.; Kabiraj, D.; Singh, R.P.; Mehta, D.; Chamoli, S.K.

    2014-01-01

    A thin isotopic 94 Zr target of thickness 520μg/cm 2 has been prepared for recoil distance Doppler shift method (RDM) lifetime measurement by using an electron beam deposition method on tantalum backing of 3.5 mg/cm 2 thickness at Inter University Accelerator Center (IUAC), New Delhi. To meet the special requirement of smoothness of surface for RDM lifetime measurement and also to protect the outer layer of 94 Zr from peeling off, a very thin layer of gold has been evaporated on a 94 Zr target on a specially designed substrate holder. In all, 143 mg of 99.6% enriched 94 Zr target material was utilized for the fabrication of 94 Zr targets. The target has been successfully used in a recent RDM lifetime measurement experiment at IUAC

  15. Fabrication of 94Zr thin target for recoil distance doppler shift method of lifetime measurement

    Science.gov (United States)

    Gupta, C. K.; Rohilla, Aman; Abhilash, S. R.; Kabiraj, D.; Singh, R. P.; Mehta, D.; Chamoli, S. K.

    2014-11-01

    A thin isotopic 94Zr target of thickness 520 μg /cm2 has been prepared for recoil distance Doppler shift method (RDM) lifetime measurement by using an electron beam deposition method on tantalum backing of 3.5 mg/cm2 thickness at Inter University Accelerator Center (IUAC), New Delhi. To meet the special requirement of smoothness of surface for RDM lifetime measurement and also to protect the outer layer of 94Zr from peeling off, a very thin layer of gold has been evaporated on a 94Zr target on a specially designed substrate holder. In all, 143 mg of 99.6% enriched 94Zr target material was utilized for the fabrication of 94Zr targets. The target has been successfully used in a recent RDM lifetime measurement experiment at IUAC.

  16. Fabrication of {sup 94}Zr thin target for recoil distance doppler shift method of lifetime measurement

    Energy Technology Data Exchange (ETDEWEB)

    Gupta, C.K.; Rohilla, Aman [Department of Physics and Astrophysics, University of Delhi, Delhi 110007 (India); Abhilash, S.R.; Kabiraj, D.; Singh, R.P. [Inter University Accelerator Centre, Aruna Asaf Ali Marg, New Delhi 110067 (India); Mehta, D. [Department of Physics, Panjab University, Chandigarh 160014 (India); Chamoli, S.K., E-mail: skchamoli@physics.du.ac.in [Department of Physics and Astrophysics, University of Delhi, Delhi 110007 (India)

    2014-11-11

    A thin isotopic {sup 94}Zr target of thickness 520μg/cm{sup 2} has been prepared for recoil distance Doppler shift method (RDM) lifetime measurement by using an electron beam deposition method on tantalum backing of 3.5 mg/cm{sup 2} thickness at Inter University Accelerator Center (IUAC), New Delhi. To meet the special requirement of smoothness of surface for RDM lifetime measurement and also to protect the outer layer of {sup 94}Zr from peeling off, a very thin layer of gold has been evaporated on a {sup 94}Zr target on a specially designed substrate holder. In all, 143 mg of 99.6% enriched {sup 94}Zr target material was utilized for the fabrication of {sup 94}Zr targets. The target has been successfully used in a recent RDM lifetime measurement experiment at IUAC.

  17. Fabrication and testing of gas filled targets for large scale plasma experiments on Nova

    International Nuclear Information System (INIS)

    Stone, G.F.; Spragge, M.; Wallace, R.J.; Rivers, C.J.

    1995-01-01

    An experimental campaign on the Nova laser was started in July 1993 to study one st of target conditions for the point design of the National Ignition Facility (NIF). The targets were specified to investigate the current NIF target conditions--a plasma of ∼3 keV electron temperature and an electron density of ∼1.0 E + 21 cm -3 . A gas cell target design was chosen to confine as gas of ∼0.01 cm 3 in volume at ∼ 1 atmosphere. This paper will describe the major steps and processes necessary in the fabrication, testing and delivery of these targets for shots on the Nova Laser at LLNL

  18. SYNTHESIS AND FABRICATION OF MO-W COMPONENTS FOR NEUTRON RESONANCE SPECTROSCOPY TEMPERATURE MEASUREMENT

    International Nuclear Information System (INIS)

    BINGERT, S.; DESCH, P.; TRUJILLO, E.

    1999-01-01

    A Molybdenum-- 182 Tungsten (Mo- 182 W) alloy was specified for an application that would ultimately result in the measurement of temperature and particle velocity during the steady state time following the shock loading of various materials. The 182 W isotope provides a tag for the analysis of neutron resonance line shape from which the temperature may be calculated. The material was specified to have 1.8 atom percent W, with W-rich regions no larger than 1 microm in size. Both the composition and W distribution were critical to the experiment. Another challenge to the processing was the very small quantity of 182 W material available for the synthesis of the alloy. Therefore, limited fabrication routes were available for evaluation. Several synthesis and processing routes were explored to fabricate the required alloy components. First, precipitation of W onto Mo powder using ammonium metatungstate was investigated for powder synthesis followed by uniaxial hot pressing. Second, mechanical alloying (MA) followed by hot isostatic pressing (HIP) and warm forging was attempted. Finally, arc-melting techniques followed by either hot rolling or crushing the alloyed button into powder and consolidation were pursued. The results of the processing routes and characterization of the materials produced will be discussed

  19. Fabrication and testing of W7-X pre-series target elements

    International Nuclear Information System (INIS)

    Boscary, J; Boeswirth, B; Greuner, H; Grigull, P; Missirlian, M; Plankensteiner, A; Schedler, B; Friedrich, T; Schlosser, J; Streibl, B; Traxler, H

    2007-01-01

    The assembly of the highly-loaded target plates of the WENDELSTEIN 7-X (W7-X) divertor requires the fabrication of 890 target elements (TEs). The plasma facing material is made of CFC NB31 flat tiles bonded to a CuCrZr copper alloy water-cooled heat sink. The elements are designed to remove a stationary heat flux and power up to 10 MW m -2 and 100 kW, respectively. Before launching the serial fabrication, pre-series activities aimed at qualifying the design, the manufacturing route and the non-destructive examinations (NDEs). High heat flux (HHF) tests performed on full-scale pre-series TEs resulted in an improvement of the design of the bond between tiles and heat sink to reduce the stresses during operation. The consequence is the fabrication of additional pre-series TEs to be tested in the HHF facility GLADIS. NDEs of this bond based on thermography methods are developed to define the acceptance criteria suitable for serial fabrication

  20. Information-management data base for fusion-target fabrication processes

    International Nuclear Information System (INIS)

    Reynolds, J.

    1982-01-01

    A computer-based data-management system has been developed to handle data associated with target-fabrication processes including glass microballoon characterization, gas filling, materials coating, and storage locations. The system provides automatic data storage and computation, flexible data-entry procedures, fast access, automated report generation, and secure data transfer. It resides on a CDC CYBER 175 computer and is compatible with the CDC data-base-language Query Update, but is based on custom FORTRAN software interacting directly with the CYBER's file-management system. The described data base maintains detailed, accurate, and readily available records of fusion targets information

  1. Design and Fabrication Technique of the Key Components for Very High Temperature Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Ho Jin; Song, Ki Nam; Kim, Yong Wan

    2006-12-15

    The gas outlet temperature of Very High Temperature Reactor (VHTR) may be beyond the capability of conventional metallic materials. The requirement of the gas outlet temperature of 950 .deg. C will result in operating temperatures for metallic core components that will approach very high temperature on some cases. The materials that are capable of withstanding this temperature should be prepared, or nonmetallic materials will be required for limited components. The Ni-base alloys such as Alloy 617, Hastelloy X, XR, Incoloy 800H, and Haynes 230 are being investigated to apply them on components operated in high temperature. Currently available national and international codes and procedures are needed reviewed to design the components for HTGR/VHTR. Seven codes and procedures, including five ASME Codes and Code cases, one French code (RCC-MR), and on British Procedure (R5) were reviewed. The scope of the code and code cases needs to be expanded to include the materials with allowable temperatures of 950 .deg. C and higher. The selection of compact heat exchangers technology depends on the operating conditions such as pressure, flow rates, temperature, but also on other parameters such as fouling, corrosion, compactness, weight, maintenance and reliability. Welding, brazing, and diffusion bonding are considered proper joining processes for the heat exchanger operating in the high temperature and high pressure conditions without leakage. Because VHTRs require high temperature operations, various controlled materials, thick vessels, dissimilar metal joints, and precise controls of microstructure in weldment, the more advanced joining processes are needed than PWRs. The improved solid joining techniques are considered for the IHX fabrication. The weldability for Alloy 617 and Haynes 230 using GTAW and SMAW processes was investigated by CEA.

  2. Design and Fabrication Technique of the Key Components for Very High Temperature Reactor

    International Nuclear Information System (INIS)

    Lee, Ho Jin; Song, Ki Nam; Kim, Yong Wan

    2006-12-01

    The gas outlet temperature of Very High Temperature Reactor (VHTR) may be beyond the capability of conventional metallic materials. The requirement of the gas outlet temperature of 950 .deg. C will result in operating temperatures for metallic core components that will approach very high temperature on some cases. The materials that are capable of withstanding this temperature should be prepared, or nonmetallic materials will be required for limited components. The Ni-base alloys such as Alloy 617, Hastelloy X, XR, Incoloy 800H, and Haynes 230 are being investigated to apply them on components operated in high temperature. Currently available national and international codes and procedures are needed reviewed to design the components for HTGR/VHTR. Seven codes and procedures, including five ASME Codes and Code cases, one French code (RCC-MR), and on British Procedure (R5) were reviewed. The scope of the code and code cases needs to be expanded to include the materials with allowable temperatures of 950 .deg. C and higher. The selection of compact heat exchangers technology depends on the operating conditions such as pressure, flow rates, temperature, but also on other parameters such as fouling, corrosion, compactness, weight, maintenance and reliability. Welding, brazing, and diffusion bonding are considered proper joining processes for the heat exchanger operating in the high temperature and high pressure conditions without leakage. Because VHTRs require high temperature operations, various controlled materials, thick vessels, dissimilar metal joints, and precise controls of microstructure in weldment, the more advanced joining processes are needed than PWRs. The improved solid joining techniques are considered for the IHX fabrication. The weldability for Alloy 617 and Haynes 230 using GTAW and SMAW processes was investigated by CEA

  3. Applications of ultrasonic phased array technique during fabrication of nuclear tubing and other components for the Indian nuclear power program

    International Nuclear Information System (INIS)

    Kapoor, K.

    2015-01-01

    Ultrasonic phased array technique has been applied in fabrication of nuclear fuel and structural at NFC. The integrity of the nuclear fuel and structural components is most crucial as they are exposed to severe environment during operation leading to rapid degradation of its properties during its lifecycle. Nuclear Fuel Complex has mandate for the fabrication of the nuclear fuel and core structurals for Indian PHWRs/BWR, sub-assemblies for the PFBR and steam generator tubing for PFBR and PHWRs which are the most critical materials for the Indian Nuclear Power program. NDE during fabrication of these materials is thus most crucial as it provides the confidence to the designer for safe operation during its lifetime. Many of these techniques have to be developed in-house to meet unique requirements of high sensitivity, resolution and shape of the components. Some of the advancements in the NDE during the fabrication include use of ultrasonic phased array which is detailed in this paper

  4. Antibacterial performance of polypropylene nonwoven fabric wound dressing surfaces containing passive and active components

    Energy Technology Data Exchange (ETDEWEB)

    Xin, Zhirong, E-mail: xinzhirong2012@126.com [School of Chemistry and Chemical Engineering, Yantai University, Yantai 264005 (China); Du, Shanshan; Zhao, Chunyu; Chen, Hao; Sun, Miao [School of Chemistry and Chemical Engineering, Yantai University, Yantai 264005 (China); Yan, Shunjie [State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Luan, Shifang, E-mail: sfluan@ciac.ac.cn [State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 (China); Yin, Jinghua [State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 (China)

    2016-03-01

    Graphical abstract: - Highlights: • PNVP and PHMG components were covalently immobilized on PP{sub NWF} surface. • PP{sub NWF}-g-PNVP-PHMG possessed bacterial adhesion-resistant and bactericidal capabilities. • PP{sub NWF}-g-PNVP-PHMG obviously suppressed platelet and red blood cell adhesion. - Abstract: A growing number of wound dressing-related nosocomial infections necessitate the development of novel antibacterial strategies. Herein, polypropylene non-woven fabric (PP{sub NWF}) was facilely modified with passive and active antibacterial components, namely photografting polymerization both N-Vinyl-2-pyrrolidone (NVP) and glycidyl methacrylate (GMA) monomers, and the introduction of guanidine polymer through the reaction between active amino groups and epoxy groups. The modified samples were confirmed by attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), X-ray photoelectron spectroscopy (XPS), respectively. Water contact angle measurement, antibacterial test, platelet and red blood cell adhesion were used to evaluate the hydrophilicity, antibacterial properties and hemocompatibility of the samples. It was found that the antibacterial properties were obviously enhanced, meanwhile significantly suppressing platelet and red blood cell adhesion after the above modification. This PP{sub NWF} samples that possess antifouling and antimicrobial properties, have great potential in wound dressing applications.

  5. Antibacterial performance of polypropylene nonwoven fabric wound dressing surfaces containing passive and active components

    International Nuclear Information System (INIS)

    Xin, Zhirong; Du, Shanshan; Zhao, Chunyu; Chen, Hao; Sun, Miao; Yan, Shunjie; Luan, Shifang; Yin, Jinghua

    2016-01-01

    Graphical abstract: - Highlights: • PNVP and PHMG components were covalently immobilized on PP_N_W_F surface. • PP_N_W_F-g-PNVP-PHMG possessed bacterial adhesion-resistant and bactericidal capabilities. • PP_N_W_F-g-PNVP-PHMG obviously suppressed platelet and red blood cell adhesion. - Abstract: A growing number of wound dressing-related nosocomial infections necessitate the development of novel antibacterial strategies. Herein, polypropylene non-woven fabric (PP_N_W_F) was facilely modified with passive and active antibacterial components, namely photografting polymerization both N-Vinyl-2-pyrrolidone (NVP) and glycidyl methacrylate (GMA) monomers, and the introduction of guanidine polymer through the reaction between active amino groups and epoxy groups. The modified samples were confirmed by attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), X-ray photoelectron spectroscopy (XPS), respectively. Water contact angle measurement, antibacterial test, platelet and red blood cell adhesion were used to evaluate the hydrophilicity, antibacterial properties and hemocompatibility of the samples. It was found that the antibacterial properties were obviously enhanced, meanwhile significantly suppressing platelet and red blood cell adhesion after the above modification. This PP_N_W_F samples that possess antifouling and antimicrobial properties, have great potential in wound dressing applications.

  6. Flight service evaluation of composite components on the Bell Helicopter model 206L: Design, fabrication and testing

    Science.gov (United States)

    Zinberg, H.

    1982-01-01

    The design, fabrication, and testing phases of a program to obtain long term flight service experience on representative helicopter airframe structural components operating in typical commercial environments are described. The aircraft chosen is the Bell Helicopter Model 206L. The structural components are the forward fairing, litter door, baggage door, and vertical fin. The advanced composite components were designed to replace the production parts in the field and were certified by the FAA to be operable through the full flight envelope of the 206L. A description of the fabrication process that was used for each of the components is given. Static failing load tests on all components were done. In addition fatigue tests were run on four specimens that simulated the attachment of the vertical fin to the helicopter's tail boom.

  7. Quick look of first VEGA test and fabrication study of thoria components

    International Nuclear Information System (INIS)

    Nakamura, Takehiko; Hidaka, Akihide; Kudo, Tamotsu; Hayashida, Retsu; Ohtomo, Takashi; Nakamura, Jinichi; Uetsuka, Hiroshi

    2000-01-01

    The first fission product release test VEGA-1 was conducted on September 9, 1999 in the Reactor Fuel Examination Facility (RFEF) of JAERI Tokai using two PWR pellets at burnup of 47 GWd/tU. The fuel pellet of about 10g without cladding tube was heated up to 2500degC for 10min in an inert helium atmosphere at 0.1 MPa, following two other plateaus at 1727degC (20min) and 2027degC (20min). The release of radioactive fission products was on-line measured by 4 gamma sensors watching at the fuel in a furnace, at trapped aerosols in filters, at a condenser, and at noble gases in a charcoal trap. Gamma intensity of the fuel, which was dominated by Cs-134 and Cs-137, started to decrease, when the furnace temperature started to rise to the first plateau of 1727degC from a conditioning stage at 1350degC. Following the decease, the intensity at the filters, which was located about 2.5 m downstream of the furnace following thermal gradient tubes (TGTs) to collect the aerosols, started to increase. At about the same time, the counting rate on Kr-85 at the charcoal trap at -60degC started to rise. Preliminary releases of Cs-134, Cs-137, and Ru-106, etc. were estimated from changes of gamma-ray spectrum before/after the heating test. Total releases of the nuclides, however, will be evaluated later, by comprehensive off-line measurement of the apparatus, e.g. gamma scanning, leaching and gamma spectroscopy of pipes, the TGTs, and the filters. Development of thoria components in the VEGA furnace has been progressing for the use in high temperature tests under oxidizing atmosphere. Three kinds of slip casting techniques, i.e. centrifugal casting, drain casting and solid casting, were successfully applied to fabricate inner tubes, crucibles and caps, respectively. Calcination of the thoria powder was conducted to optimize slip characteristics for casting and sintering. Fabrication of test pieces has finished, expecting for two to four sets of the components being ready for heating

  8. Target fabrication and development in the Centre d'Etudes de Limeil

    International Nuclear Information System (INIS)

    Clement, X.; Coudeville, A.; Eyharts, P.; Perrine, J.P.; Rouillard, R.

    1983-10-01

    The present state of research in Limeil laboratory for the production of inertial confinement fusion targets is described in this communication. A summary of typical areas, previously investigated, including new developments, is as follows: - production of hollow glass microspheres, having wide outside diameter range and aspect-ratio, using dried-alcogels, - preparation and fabrication of low density foams having plane or hemispherical shape, - deposition of a wide range of conductive materials as well as silicon and organic polymers, - development of laser and spark erosion machining which are useful tools for producing minute parts of complex targets, - characterization and analysis of plastic or coal metal coated targets, are done by using interferometry techniques and X-ray image analysis as well as X-ray absorption measurements

  9. A database of wavefront measurements for laser system modeling, optical component development and fabrication process qualification

    International Nuclear Information System (INIS)

    Wolfe, C.R.; Lawson, J.K.; Aikens, D.M.; English, R.E.

    1995-01-01

    In the second half of the 1990's, LLNL and others anticipate designing and beginning construction of the National Ignition Facility (NIF). The NIF will be capable of producing the worlds first laboratory scale fusion ignition and bum reaction by imploding a small target. The NIF will utilize approximately 192 simultaneous laser beams for this purpose. The laser will be capable of producing a shaped energy pulse of at least 1.8 million joules (MJ) with peak power of at least 500 trillion watts (TV). In total, the facility will require more than 7,000 large optical components. The performance of a high power laser of this kind can be seriously degraded by the presence of low amplitude, periodic modulations in the surface and transmitted wavefronts of the optics used. At high peak power, these phase modulations can convert into large intensity modulations by non-linear optical processes. This in turn can lead to loss in energy on target via many well known mechanisms. In some cases laser damage to the optics downstream of the source of the phase modulation can occur. The database described here contains wavefront phase maps of early prototype optical components for the NIF. It has only recently become possible to map the wavefront of these large aperture components with high spatial resolution. Modem large aperture static fringe and phase shifting interferometers equipped with large area solid state detectors have made this possible. In a series of measurements with these instruments, wide spatial bandwidth can be detected in the wavefront

  10. Investigation on cryogenic laser fusion targets: fabrication, characterization, and transport. Annual report, December 1, 1978-November 30, 1979

    International Nuclear Information System (INIS)

    Kim, K.

    1979-01-01

    The research has been directed toward fabrication, characterization, and positioning of cryogenic shell laser fusion targets, with particular emphasis on the development of a scheme which would allow for continuous fabrication, inspection, and delivery of the targets. Specifically, progress has been made in the following areas: (1) Fabrication of a uniform spherical shell of DT-condensate using a cold-wall target-freezing-cell. (2) Fabrication of a uniform spherical shell of liquid DT using a room-temperature wall target-freezing-cell. (3) Support-free cryogenic target fabrication using cold-gas-levitation. (4) Continuous fabrication of cryogenic targets using free-fall method. (5) Automatic characterization of DT-layer uniformity. (6) Sorting of DT-filled glass microshells using an interference microscope. (7) Development of an a-c interference microscope for accurate characterization of moving targets. (8) Development of a machine which is capable of producing a continuous stream of uniform DT spheres of controllable sizes. (9) Theoretical study on the behavior of liquid hydrogen contained in a spherical shell

  11. Recent Developments in Fabrication of Direct Drive Cylinder Targets for Hydrodynamics Experiments at the OMEGA Laser

    International Nuclear Information System (INIS)

    Nobile, A.; Balkey, M.M.; Bartos, J.J.; Batha, S.H.; Day, R.D.; Elliott, J.E.; Elliott, N.E.; Gomez, V.M.; Hatch, D.J.; Lanier, N.E.; Fincke, J.R.; Manzanares, R.; Pierce, T.H.; Sandoval, D.L.; Schmidt, D.W.; Steckle, W.P.

    2004-01-01

    Experimental campaigns are being conducted at the 60 beam OMEGA laser at the University of Rochester's Laboratory for Laser Energetics to acquire data to validate hydrodynamic models in the high energy-density regime. This paper describes targets that have been developed and constructed for these experimental campaigns. Targets are 860 μm inner diameter by 2.2 mm length cylinders with 70 μm thick polymer ablator. On the ablator inner surface and located halfway along the axis of the cylinder is a 500 μm wide Al marker band. Band thicknesses in the range 8-16 microns are used. CH foam with densities in the range 30-90 mg/cc fills the inside of the cylinder. While these targets have been fabricated for years, several new improvements and features have recently been developed. Improvements include the use of epoxy instead of polystyrene for the ablator, and the use of electrodeposited Al for the marker band. A critical feature of the target is the surface feature that is placed on the marker band. Experiments are aimed at understanding the hydrodynamic behavior of imploding cylinders as a function of this surface feature. Recent development work has focused on production of engineered surface features on the target marker band. Using a fast tool servo on a diamond turning lathe, a wide range of specified surface features have been produced. This paper will address improvements to the cylinder targets as well as current development efforts

  12. Microstructures, Forming Limit and Failure Analyses of Inconel 718 Sheets for Fabrication of Aerospace Components

    Science.gov (United States)

    Sajun Prasad, K.; Panda, Sushanta Kumar; Kar, Sujoy Kumar; Sen, Mainak; Murty, S. V. S. Naryana; Sharma, Sharad Chandra

    2017-04-01

    Recently, aerospace industries have shown increasing interest in forming limits of Inconel 718 sheet metals, which can be utilised in designing tools and selection of process parameters for successful fabrication of components. In the present work, stress-strain response with failure strains was evaluated by uniaxial tensile tests in different orientations, and two-stage work-hardening behavior was observed. In spite of highly preferred texture, tensile properties showed minor variations in different orientations due to the random distribution of nanoprecipitates. The forming limit strains were evaluated by deforming specimens in seven different strain paths using limiting dome height (LDH) test facility. Mostly, the specimens failed without prior indication of localized necking. Thus, fracture forming limit diagram (FFLD) was evaluated, and bending correction was imposed due to the use of sub-size hemispherical punch. The failure strains of FFLD were converted into major-minor stress space ( σ-FFLD) and effective plastic strain-stress triaxiality space ( ηEPS-FFLD) as failure criteria to avoid the strain path dependence. Moreover, FE model was developed, and the LDH, strain distribution and failure location were predicted successfully using above-mentioned failure criteria with two stages of work hardening. Fractographs were correlated with the fracture behavior and formability of sheet metal.

  13. A study on embedded resistor components fabricated by laser micro-cladding and rapid prototype

    International Nuclear Information System (INIS)

    Li Huiling; Zeng Xiaoyan

    2006-01-01

    With the rapid development of IC and packaging, electronic devices are required to be smaller, to have a high-density integration, to become multifunction and to be of lower cost and high-reliability. Thick-film technology is not able to meet the current developing demands because of its shortcomings, such as the limit of pattern resolution, the severe torsion and delay of high-speed signal transmission. The speed and quality of signal transmission will be improved if embedded resistor components are directly integrated in the multiplayer substrate of multi-chip or laminated module, and high-density integration and reliability are achieved because the short interconnection and the less soldering point. In this paper, a technique named laser micro-cladding and rapid prototype is used to directly fabricate embedded resistor units on the multiplayer ceramic substrate without using a mask and high-temperature sintering, and without trimming resistor, which will simplify processing and decrease cost as well as improving high-speed and reliable performance

  14. Fabrication and characterization of joined silicon carbide cylindrical components for nuclear applications

    Science.gov (United States)

    Khalifa, H. E.; Deck, C. P.; Gutierrez, O.; Jacobsen, G. M.; Back, C. A.

    2015-02-01

    The use of silicon carbide (SiC) composites as structural materials in nuclear applications necessitates the development of a viable joining method. One critical application for nuclear-grade joining is the sealing of fuel within a cylindrical cladding. This paper demonstrates cylindrical joint feasibility using a low activation nuclear-grade joint material comprised entirely of β-SiC. While many papers have considered joining material, this paper takes into consideration the joint geometry and component form factor, as well as the material performance. Work focused specifically on characterizing the strength and permeability performance of joints between cylindrical SiC-SiC composites and monolithic SiC endplugs. The effects of environment and neutron irradiation were not evaluated in this study. Joint test specimens of different geometries were evaluated in their as-fabricated state, as well as after being subjected to thermal cycling and partial mechanical loading. A butted scarf geometry supplied the best combination of high strength and low permeability. A leak rate performance of 2 × 10-9 mbar l s-1 was maintained after thermal cycling and partial mechanical loading and sustained applied force of 3.4 kN, or an apparent strength of 77 MPa. This work shows that a cylindrical SiC-SiC composite tube sealed with a butted scarf endplug provides out-of-pile strength and permeability performance that meets light water reactor design requirements.

  15. Development and fabrication aspects regarding tungsten components for a He-cooled divertor

    International Nuclear Information System (INIS)

    Krauss, W.; Holstein, N.; Konys, J.

    2005-01-01

    Under the EU framework of power plant conceptual study (PPCS), a modular He-cooled divertor concept is investigated, which is projected to remove high heat loads of up to 15 MW/m 2 . This design is based on a modular arrangement of cooling fingers consisting of a tile acting as sacrificial layer, a thimble through-flowed by high pressurized He and special micro-structured components for enhanced heat transfer. The success of this design is strongly correlated to the availability of special tungsten alloys and for the pin/slot option efficient micro-structuring of W or W-1% La 2 O 3 arrays. An evaluation of shaping technologies for array manufacturing under consideration of applicability, degree of development status, expected effectiveness and economy was performed and the most promising methods were tested. Based on the today's knowledge, electrical discharge machining (EDM) and laser etching (LE) allow the shaping of slot arrays; however, an impact on microstructure was detected. Technologies like powder injection moulding (PIM) or electro-chemically assisted machining processes (ECM) need further development and testing to be applied as reliable fabrication processes in structuring of W-alloys

  16. Pre-series and testing route for the serial fabrication of W7-X target elements

    International Nuclear Information System (INIS)

    Boscary, J.; Greuner, H.; Friedrich, T.; Traxler, H.; Mendelevitch, B.; Boeswirth, B.; Schlosser, J.; Smirnow, M.; Stadler, R.

    2009-01-01

    The fabrication of the actively cooled high-heat flux divertor of the WENDELSTEIN 7-X stellarator (W7-X) requires the delivery of 890 target elements, which are designed to withstand a stationary heat flux of 10 MW/m 2 . The organization of the manufacturing and testing route for the serial fabrication is the result of the pre-series activities. Flat CFC Sepcarb NB31 tiles are bonded to CuCrZr copper alloy cooling structure in consecutive steps. A copper layer is active metal cast to CFC tiles, and then an OF-copper layer is added by hot isostatic pressing to produce bi-layer tiles. These tiles are bonded by electron beam welding onto the cooling structure, which was manufactured independently. The introduction of the bi-layer technology proved to be a significant improvement of the bond reliability under thermal cycling loading. This result is also the consequence of the improved bond inspections throughout the manufacturing route performed in the ARGUS pulsed thermography facility of PLANSEE. The repairing process by electron beam welding of the bonding was also qualified. The extended pre-series activities related to the qualification of fabrication processes with the relevant non-destructive examinations aim to minimize the risks for the serial manufacturing and to guarantee the steady-state operation of the W7-X divertor.

  17. An Effort to Improve U Foil Fabrication Technology of Roll-casting for Fission Mo Target

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Chang Kyu; Woo, Yun Myeong; Kim, Ki Hwan; Oh, Jong Myeong [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Sim, Moon Soo [Chungnam University, Green Energy Technology, Daejeon (Korea, Republic of)

    2010-10-15

    Mo-99 isotope has been produced mainly by extracting fission products of {sup 235}U. The targets for irradiating in reactor have used as stainless tube coated with highly enriched UO{sub 2} at the inside surface and highly enriched UAlx plate cladded with aluminum. In connection with non-proliferation policy the RERTR program developed a new process of Mo-99 using low enriched uranium (LEU) instead of highly enriched uranium (HEU). LEU should be put about five times more quantity than HEU because the {sup 235}U contents of LEU and HEU are 20% and higher than 90%, respectively. Accordingly pure uranium metal foil target was adopted as a promising target material due to high uranium density. ANL and BATAN developed a Cintichem process using uranium metal foil target of 130 {mu}m in thickness jointly and the RERTR program is trying to disseminate the new process world-widely. However, uranium foil is made by lots of times rolling work on uranium plate, which is laborious and tedious. In order to avoid this difficulty KAERI developed a new process of making foil directly from uranium melt by roll casting. This process is very much simple, productive, and cost-effective. But the outside surface of foil is generally very rough. A typical transverse cross section had a minimum thickness of 65 {mu}m and a maximum thickness of 205 {mu}m. This roughness could affect (1) target fabrication, where the U foil, or the Ni foil might be damaged during drawing, and (2) irradiation behavior, where gaps between the target walls and the U metal might affect cooling of the target

  18. Production management and quality assurance for the fabrication of the In-Vessel Components of the stellarator Wendelstein 7-X

    Energy Technology Data Exchange (ETDEWEB)

    Li, C., E-mail: chuanfei.li@ipp.mpg.de; Boscary, J.; Dekorsy, N.; Junghanns, P.; Mendelevitch, B.; Peacock, A.; Pirsch, H.; Sellmeier, O.; Springer, J.; Stadler, R.; Streibl, B.

    2014-10-15

    Highlights: • Thousand parts for the divertor, first wall, cooling supply and diagnostics as W7-X In-Vessel Components. • Database building including part and assembly data, work and capacity organization, quality assurance documents. • Production management system to organize the fabrication and the associated quality assurance. • Successful use of an efficient and flexible product planning and scheduling tool for W7-X In-Vessel Components. - Abstract: The In-Vessel Components (IVC) of the stellarator Wendelstein 7-X consist of the divertor components and the first wall (FW) with their internal water cooling supply and a set of diagnostics. Due to the significant amount of different components, including many variants, a tool called Production Managing System (PMS) has been developed to organize the fabrication and the associated quality assurance. The PMS works by building a database containing the basic parts and assembly data, manufacturing and quality control plans, and available machine capacity. The creation of this database is based mainly on the parts lists, the manufacturing drawings, and details of the working flow organization. As a consequence of the learning process and technical adjustments during the design and manufacturing phase, the database needed to be permanently updated. Therefore an interface tool to optimize the data preparation has been developed. PMS has been demonstrated to be an efficient tool to support the IVC production activities providing reliable planning estimates, easily adaptable to problems encountered during the fabrication and provided a basis for the integration of quality assurance requirements.

  19. Production management and quality assurance for the fabrication of the In-Vessel Components of the stellarator Wendelstein 7-X

    International Nuclear Information System (INIS)

    Li, C.; Boscary, J.; Dekorsy, N.; Junghanns, P.; Mendelevitch, B.; Peacock, A.; Pirsch, H.; Sellmeier, O.; Springer, J.; Stadler, R.; Streibl, B.

    2014-01-01

    Highlights: • Thousand parts for the divertor, first wall, cooling supply and diagnostics as W7-X In-Vessel Components. • Database building including part and assembly data, work and capacity organization, quality assurance documents. • Production management system to organize the fabrication and the associated quality assurance. • Successful use of an efficient and flexible product planning and scheduling tool for W7-X In-Vessel Components. - Abstract: The In-Vessel Components (IVC) of the stellarator Wendelstein 7-X consist of the divertor components and the first wall (FW) with their internal water cooling supply and a set of diagnostics. Due to the significant amount of different components, including many variants, a tool called Production Managing System (PMS) has been developed to organize the fabrication and the associated quality assurance. The PMS works by building a database containing the basic parts and assembly data, manufacturing and quality control plans, and available machine capacity. The creation of this database is based mainly on the parts lists, the manufacturing drawings, and details of the working flow organization. As a consequence of the learning process and technical adjustments during the design and manufacturing phase, the database needed to be permanently updated. Therefore an interface tool to optimize the data preparation has been developed. PMS has been demonstrated to be an efficient tool to support the IVC production activities providing reliable planning estimates, easily adaptable to problems encountered during the fabrication and provided a basis for the integration of quality assurance requirements

  20. Fabrication of a nanocarrier system through self-assembly of plasma protein and its tumor targeting

    International Nuclear Information System (INIS)

    Gong Guangming; Zhi Feng; Wang Kaikai; Tang Xiaolei; Yuan Ahu; Zhao Lili; Ding Dawei; Hu Yiqiao

    2011-01-01

    Human serum albumin (HSA) nanoparticles hold great promise as a nanocarrier system for targeted drug delivery. The objective of this study was to explore the possibility of preparing size controllable albumin nanoparticles using the disulfide bond breaking reagent β-mercaptoethanol (β-ME). The results showed that the protein concentration and temperature had positive effects on the sizes of the albumin nanoparticles, while pH had a negative effect on the rate of nanoparticle formation. The addition of β-ME induced changes in HSA secondary structure and exposed the hydrophobic core of HSA, leading to the formation of nanoparticles. Human serum albumin nanoparticles could be internalized by MCF-7 cells and mainly accumulated in cytoplasm. After injection in tumor bearing mice, the HSA nanoparticles accumulated in tumor tissues, demonstrating the targeting ability of the nanoparticles. Therefore, human serum albumin can be fabricated into nanoparticles by breaking the disulfide bonds and these nanoparticles exhibit high tumor targeting ability. Human serum albumin nanoparticles could be ideal for the targeted delivery of pharmacologically active substances.

  1. Cost Modeling for Fabrication of Direct Drive Inertial Fusion Energy Targets

    International Nuclear Information System (INIS)

    Rickman, William Samuel; Goodin, Daniel T.

    2003-01-01

    Chemical engineering analyses are underway for a commercial-scale [1000-MW(electric)] divinyl benzene foam-based Inertial Fusion Energy (IFE) Target Fabrication Facility (TFF). This facility is designed to supply 500,000, 4-mm-outer diameter targets per day - coated via interfacial polycondensation, dried with supercritical CO 2 , sputter coated with Au and/or Pd, and filled with deuterium-tritium layered at cryogenic temperatures and injected into the fusion chamber. Such targets would be used in a direct-drive IFE power plant.The work uses manufacturing processes being developed in the laboratory, chemical engineering scaleup principles, and established cost-estimating methods. The plant conceptual design includes a process flow diagram, mass and energy balances, equipment sizing and sketches, storage tanks, and facility views.The cost estimate includes both capital and operating costs. Initial results for a TFF dedicated to one 1000-MW(electric) plant indicate that the costs per target are well within the commercially viable range. Larger TFF plants [3000 MW(electric)] are projected to lead to significantly reduced costs per injected target. Additional cost reductions are possible by producing dried, sputter-coated empty shells at a central facility that services multiple power plants.The results indicate that the installed capital cost is about $100 million and the annual operating costs will be about $20 million, for a cost per target of about $0.17 each. These design and cost projections assume that a significant process development and scaleup program is successfully completed for all of the basic unit operations included in the facility

  2. A CNC Sheetmetal Fabrication System for Production of Ships Ventilation Components and Flatwork

    National Research Council Canada - National Science Library

    Galie, Thomas R; Blais, David R

    1981-01-01

    .... By utilizing computer graphics technology and Computer Numeric Control (CNC) machine tools, it is possible to reduce the manhours required for fabrication of ventilation and flatwork by as much as 40 percent...

  3. Ultra-hard AlMgB14 coatings fabricated by RF magnetron sputtering from a stoichiometric target

    Science.gov (United States)

    Grishin, A. M.; Khartsev, S. I.; Böhlmark, J.; Ahlgren, M.

    2015-01-01

    For the first time hard aluminum magnesium boride films were fabricated by RF magnetron sputtering from a single stoichiometric ceramic AlMgB14 target. Optimized processing conditions (substrate temperature, target sputtering power and target-to-substrate distance) enable fabrication of stoichiometric in-depth compositionally homogeneous films with the peak values of nanohardness 88 GPa and Young's modulus 517 GPa at the penetration depth of 26 nm and, respectively, 35 and 275 GPa at 200 nm depth in 2 μm thick film.

  4. Fabrication of high specificity hollow mesoporous silica nanoparticles assisted by Eudragit for targeted drug delivery.

    Science.gov (United States)

    She, Xiaodong; Chen, Lijue; Velleman, Leonora; Li, Chengpeng; Zhu, Haijin; He, Canzhong; Wang, Tao; Shigdar, Sarah; Duan, Wei; Kong, Lingxue

    2015-05-01

    Hollow mesoporous silica nanoparticles (HMSNs) are one of the most promising carriers for effective drug delivery due to their large surface area, high volume for drug loading and excellent biocompatibility. However, the non-ionic surfactant templated HMSNs often have a broad size distribution and a defective mesoporous structure because of the difficulties involved in controlling the formation and organization of micelles for the growth of silica framework. In this paper, a novel "Eudragit assisted" strategy has been developed to fabricate HMSNs by utilising the Eudragit nanoparticles as cores and to assist in the self-assembly of micelle organisation. Highly dispersed mesoporous silica spheres with intact hollow interiors and through pores on the shell were fabricated. The HMSNs have a high surface area (670 m(2)/g), small diameter (120 nm) and uniform pore size (2.5 nm) that facilitated the effective encapsulation of 5-fluorouracil within HMSNs, achieving a high loading capacity of 194.5 mg(5-FU)/g(HMSNs). The HMSNs were non-cytotoxic to colorectal cancer cells SW480 and can be bioconjugated with Epidermal Growth Factor (EGF) for efficient and specific cell internalization. The high specificity and excellent targeting performance of EGF grafted HMSNs have demonstrated that they can become potential intracellular drug delivery vehicles for colorectal cancers via EGF-EGFR interaction. Copyright © 2014 Elsevier Inc. All rights reserved.

  5. Biased Target Ion Beam Deposition and Nanoskiving for Fabricating NiTi Alloy Nanowires

    Science.gov (United States)

    Hou, Huilong; Horn, Mark W.; Hamilton, Reginald F.

    2016-12-01

    Nanoskiving is a novel nanofabrication technique to produce shape memory alloy nanowires. Our previous work was the first to successfully fabricate NiTi alloy nanowires using the top-down approach, which leverages thin film technology and ultramicrotomy for ultra-thin sectioning. For this work, we utilized biased target ion beam deposition technology to fabricate nanoscale (i.e., sub-micrometer) NiTi alloy thin films. In contrast to our previous work, rapid thermal annealing was employed for heat treatment, and the B2 austenite to R-phase martensitic transformation was confirmed using stress-temperature and diffraction measurements. The ultramicrotome was programmable and facilitated sectioning the films to produce nanowires with thickness-to-width ratios ranging from 4:1 to 16:1. Energy dispersive X-ray spectroscopy analysis confirmed the elemental Ni and Ti make-up of the wires. The findings exposed the nanowires exhibited a natural ribbon-like curvature, which depended on the thickness-to-width ratio. The results demonstrate nanoskiving is a potential nanofabrication technique for producing NiTi alloy nanowires that are continuous with an unprecedented length on the order of hundreds of micrometers.

  6. Novel materials, fabrication techniques and algorithms for microwave and THz components, systems and applications

    Science.gov (United States)

    Liang, Min

    This dissertation presents the investigation of several additive manufactured components in RF and THz frequency, as well as the applications of gradient index lens based direction of arrival (DOA) estimation system and broadband electronically beam scanning system. Also, a polymer matrix composite method to achieve artificially controlled effective dielectric properties for 3D printing material is studied. Moreover, the characterization of carbon based nano-materials at microwave and THz frequency, photoconductive antenna array based Terahertz time-domain spectroscopy (THz-TDS) near field imaging system, and a compressive sensing based microwave imaging system is discussed in this dissertation. First, the design, fabrication and characterization of several 3D printed components in microwave and THz frequency are presented. These components include 3D printed broadband Luneburg lens, 3D printed patch antenna, 3D printed multilayer microstrip line structure with vertical transition, THz all-dielectric EMXT waveguide to planar microstrip transition structure and 3D printed dielectric reflectarrays. Second, the additive manufactured 3D Luneburg Lens is employed for DOA estimation application. Using the special property of a Luneburg lens that every point on the surface of the Lens is the focal point of a plane wave incident from the opposite side, 36 detectors are mounted around the surface of the lens to estimate the direction of arrival (DOA) of a microwave signal. The direction finding results using a correlation algorithm show that the averaged error is smaller than 1º for all 360 degree incident angles. Third, a novel broadband electronic scanning system based on Luneburg lens phased array structure is reported. The radiation elements of the phased array are mounted around the surface of a Luneburg lens. By controlling the phase and amplitude of only a few adjacent elements, electronic beam scanning with various radiation patterns can be easily achieved

  7. Conception and fabrication of innovative Am-Based targets: the ca mix/Cochix experiment

    International Nuclear Information System (INIS)

    Schmidt, N.; Croixmarie, Y.; Abonneau, E.; Ottaviani, J.P.; Donnet, L.; Desmouliere, F.; Konings, R.J.M.; Fernandez, A.

    2003-01-01

    A large experimental programme has been planned to be carried out in the French PHENIX reactor. The purpose is to evaluate the technical feasibility of minor actinide transmutation in fast reactors. Two major series of experiments have been designed for the heterogeneous transmutation mode. The first one, the MATINA (Matrices for Incineration of Actinides) series, aims at testing both different inert matrices in a fast flux and different concepts. The study is generic and focuses on the material behaviour under representative irradiation conditions. Targets are free of minor actinides to make the fabrication and design steps easier and faster. The second one, ECRIX, CAMIX (Compounds of Americium in PHENIX) and COCHIX (Concept Optimized microstructure in PHENIX), is a further step in the demonstration phase of the ''once-through'' transmutation and deals with Am-bearing targets irradiated in a fast neutron spectrum ''locally'' moderated. The moderator materials tested will be calcium hydride CaH 2-x (cases of ECRIX-H, CAMIX and COCHIX) and boron carbide 11 B 4 C (case of ECRIX-B) in order to accelerate the process of transmutation significantly. (author)

  8. Fabrication Method of the Mo-99 Target with Advanced Planar Flow Casting

    Energy Technology Data Exchange (ETDEWEB)

    Sim, M. S.; Lee, J. H. [Chungnam University, Green Energy Technology, Daejeon (Korea, Republic of); Kim, C. K.; Woo, Y. M. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2011-05-15

    Mo-99 is a parent isotope of Tc-99m for medical diagnosis and very significant owing to its large fraction over 80% of the whole demand of medical radioisotopes in the all countries. Mo-99 isotope has been produced mainly by {sup 235}U which is extracting fission products. All the major providers of fission Mo have used HEU as a target material. But RERTR program that is non-proliferation policy encourages using HEU to LEU. KAERI has developed a processing to be able to produce a uranium foil continuously at one go. This processing gave an opportunity for LEU target using uranium foil to be commercialized. It correspond RERTR program. KAERI developed a new process of making foil directly from uranium melt by PFC. This process is simple, productive, and cost-effective. But the foil{center_dot}{center_dot}{center_dot}s air-side surface is generally very rough. A typical transverse cross section had a minimum thickness of 65 {mu}m and a maximum thickness of 205 {mu}m. This roughness could affect target fabrication and irradiation behavior. After issuing this problem KAERI launched a further effort since 2008. A new equipment was designed and manufactured in the industry in 2009. While the new equipment being test-operating, some occurrence of appearing problems appeared. Since 2010, Equipment was moved to KAERI, we performed many experiments using depleted uranium, and go get satisfied some results. We have got interesting results and manufactured uranium foil. A typical transverse cross section had a minimum thickness of 87 {mu}m and a maximum thickness of 194 {mu}m. However, the average thickness is 130 {mu}m as a result of measurement by a micrometer

  9. Fabrication Method of the Mo-99 Target with Advanced Planar Flow Casting

    International Nuclear Information System (INIS)

    Sim, M. S.; Lee, J. H.; Kim, C. K.; Kim, W. J.

    2011-01-01

    Mo-99 is a parent isotope of Tc-99m for medical diagnosis and very significant owing to its large fraction over 80% of the whole demand of medical radioisotopes in the all countries. Mo-99 isotope has been produced mainly by 235 U which is extracting fission products. All the major providers of fission Mo have used HEU as a target material. But RERTR program that is nonproliferation policy encourages using HEU to LEU. KAERI has developed a processing to be able to produce a uranium foil continuously at one go. This processing gave an opportunity for LEU target using uranium foil to be commercialized. It correspond RERTR program. KAERI developed a new process of making foil directly from uranium melt by PFC. This process is simple, productive, and cost-effective. But the foil's air-side surface is generally very rough. A typical transverse cross section had a minimum thickness of 65 μm and a maximum thickness of 205 μm. This roughness could affect target fabrication and irradiation behavior. After issuing this problem KAERI launched a further effort since 2008. A new equipment was designed and manufactured in the industry in 2009. While the new equipment being test-operating, some occurrence of appearing problems appeared. Since 2010, Equipment was moved to KAERI, we performed many experiments using depleted uranium, and go get satisfied some results. We have got interesting results and manufactured uranium foil. A typical transverse cross section had a minimum thickness of 87 μm and a maximum thickness of 194 μm. The average thickness is 120 μm as a result of calculation

  10. An assessment of independent component analysis for detection of military targets from hyperspectral images

    Science.gov (United States)

    Tiwari, K. C.; Arora, M. K.; Singh, D.

    2011-10-01

    Hyperspectral data acquired over hundreds of narrow contiguous wavelength bands are extremely suitable for target detection due to their high spectral resolution. Though spectral response of every material is expected to be unique, but in practice, it exhibits variations, which is known as spectral variability. Most target detection algorithms depend on spectral modelling using a priori available target spectra In practice, target spectra is, however, seldom available a priori. Independent component analysis (ICA) is a new evolving technique that aims at finding out components which are statistically independent or as independent as possible. The technique therefore has the potential of being used for target detection applications. A assessment of target detection from hyperspectral images using ICA and other algorithms based on spectral modelling may be of immense interest, since ICA does not require a priori target information. The aim of this paper is, thus, to assess the potential of ICA based algorithm vis a vis other prevailing algorithms for military target detection. Four spectral matching algorithms namely Orthogonal Subspace Projection (OSP), Constrained Energy Minimisation (CEM), Spectral Angle Mapper (SAM) and Spectral Correlation Mapper (SCM), and four anomaly detection algorithms namely OSP anomaly detector (OSPAD), Reed-Xiaoli anomaly detector (RXD), Uniform Target Detector (UTD) and a combination of Reed-Xiaoli anomaly detector and Uniform Target Detector (RXD-UTD) were considered. The experiments were conducted using a set of synthetic and AVIRIS hyperspectral images containing aircrafts as military targets. A comparison of true positive and false positive rates of target detections obtained from ICA and other algorithms plotted on a receiver operating curves (ROC) space indicates the superior performance of the ICA over other algorithms.

  11. Nanograined Net-Shaped Fabrication of Rhenium Components by EB-PVD

    International Nuclear Information System (INIS)

    Singh, Jogender; Wolfe, Douglas E.

    2004-01-01

    Cost-effective net-shaped forming components have brought considerable interest into DoD, NASA and DoE. Electron beam physical vapor deposition (EB-PVD) offers flexibility in forming net-shaped components with tailored microstructure and chemistry. High purity rhenium (Re) components including rhenium-coated graphite balls, Re- plates and tubes have been successfully manufactured by EB-PVD. EB-PVD Re components exhibited sub-micron and nano-sized grains with high hardness and strength as compared to CVD. It is estimated that the cost of Re components manufactured by EB-PVD would be less than the current CVD and powder-HIP Technologies

  12. Fabrication of microstructures in aviation components with a femtosecond laser based on PZT scanning

    International Nuclear Information System (INIS)

    Yang, Xiaojun; Zhao, Wei; Li, Ming; Yang, Yong; Cheng, Guanghua; Zhao, Hualong; Li, Peng; Zhang, Huixing

    2013-01-01

    Thermal defects and low precision are the main disadvantages of fabricating micro-holes, irregular holes, and micro-slots in thermostable aviation materials. We demonstrate a manufacturing method employing a femtosecond laser and piezoelectric ceramic (PZT). The production process parameters were optimized according to the metallographic and dimensional accuracy of the microstructure, which was measured by phase-contrast microscopy and scanning electron microscopy. The limitations in a conventional aeroengine, such as in the recast layer, recrystallization, and micro-cracks, which degrade the performance and service life, were resolved with a simple, controllable, and commercial method. (paper)

  13. Near Net Shape Fabrication Technology for Shape Memory Alloy Components, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This STTR Phase I effort proposes to develop an innovative, affordable processing route for larger-sized shape memory alloy (SMA) components. Despite significant...

  14. Design and fabrication of stainless steel components for long life of spent fuel reprocessing plants

    International Nuclear Information System (INIS)

    Natarajan, R.; Ramkumar, P.; Sundararaman, V.; Kamachi Mudali, U.; Baldev Raj; Shanmugam, K.

    2010-01-01

    Reprocessing of spent nuclear fuels based on the PUREX process is the proven process with many commercial plants operating satisfactorily worldwide. The process medium being nitric acid, austenitic stainless steel is the material of construction as it is the best commercially available material for meeting the conditions in the reprocessing plants. Because of the high radiation fields, contact maintenance of equipment and systems of these plants are very time consuming and costly unlike other chemical process plants. Though the plants constructed in the early years required extensive shut downs for replacement of equipment and systems within the first fifteen years of operation itself, development in the field of stainless steel metallurgy and fabrication techniques have made it possible to design the present day plants for an operating life period of forty years. A review of the operational experience of the PUREX process based aqueous reprocessing plants has been made in this paper and reveals that life limiting failures of equipment and systems are mainly due to corrosion while a few are due to stresses. Presently there are no standards for design specification of materials and fabrication of reprocessing plants like the nuclear power plants, where well laid down ASTM and ASME codes and standards are available which are based on the large scale operational feedbacks on pressure vessels for conventional and nuclear industries. (author)

  15. Fabricating Superior NiAl Bronze Components through Wire Arc Additive Manufacturing

    Directory of Open Access Journals (Sweden)

    Donghong Ding

    2016-08-01

    Full Text Available Cast nickel aluminum bronze (NAB alloy is widely used for large engineering components in marine applications due to its excellent mechanical properties and corrosion resistance. Casting porosity, as well as coarse microstructure, however, are accompanied by a decrease in mechanical properties of cast NAB components. Although heat treatment, friction stir processing, and fusion welding were implemented to eliminate porosity, improve mechanical properties, and refine the microstructure of as-cast metal, their applications are limited to either surface modification or component repair. Instead of traditional casting techniques, this study focuses on developing NAB components using recently expanded wire arc additive manufacturing (WAAM. Consumable welding wire is melted and deposited layer-by-layer on substrates producing near-net shaped NAB components. Additively-manufactured NAB components without post-processing are fully dense, and exhibit fine microstructure, as well as comparable mechanical properties, to as-cast NAB alloy. The effects of heat input from the welding process and post-weld-heat-treatment (PWHT are shown to give uniform NAB alloys with superior mechanical properties revealing potential marine applications of the WAAM technique in NAB production.

  16. 76 FR 12942 - Proposed Information Collection; Comment Request; Defining Target Levels for Ecosystem Components...

    Science.gov (United States)

    2011-03-09

    ... Collection; Comment Request; Defining Target Levels for Ecosystem Components: A Socio-Ecological Approach... inception, the Puget Sound ecosystem has become a national example of ecosystem-based management (EBM) implementation. The Partnership Action Agenda indentified 80 near-term actions that are required for ecosystem...

  17. Imaging axial and radial electric field components in dielectric targets under plasma exposure

    NARCIS (Netherlands)

    Slikboer, E.T.; Sobota, A.; Guaitella, O.; Garcia-Caurel, E.

    2018-01-01

    This work presents new ways to investigate the individual electric field components in a dielectric target induced by a non thermal atmospheric pressure plasma jet. Mueller polarimetry is applied to investigate electro-optic crystals under exposure of guided ionization waves produced by a plasma

  18. [WMN: a negative ERPs component related to working memory during non-target visual stimuli processing].

    Science.gov (United States)

    Zhao, Lun; Wei, Jin-he

    2003-10-01

    To study non-target stimuli processing in the brain. Features of the event-related potentials (ERPs) from non-target stimuli during selective response task (SR) was compared with that during visual selective discrimination (DR) task in 26 normal subjects. The stimuli consisted of two color LED flashes (red and green) appeared randomly in left (LVF) or right (RVF) visual field with same probability. ERPs were derived at 9 electrode sites on the scalp under 2 task conditions: a) SR, making switch response to the target (NT) stimuli from LVF or RVF in one direction and making no response to the non-target (NT) ones; b) DR, making switching response to T stimuli differentially, i.e., to the left for T from LVF and to the right for T from RVF. 1) the non-target stimuli in DR conditions, compared with that in SR condition, elicited smaller P2 and P3 components and larger N2 component at the frontal brain areas; 2) a significant negative component, named as WMN (working memory negativity), appeared in the non-target ERPs during DR in the period of 100 to 700 ms post stimulation which was predominant at the frontal brain areas. According to the major difference between brain activities for non-target stimuli during SR and DR, the predominant appearance of WMN at the frontal brain areas demonstrated that the non-target stimulus processing was an active process and was related to working memory, i.e., the temporary elimination and the retrieval of the response mode which was stored in working memory.

  19. Damage evaluation under thermal fatigue of a vertical target full scale component for the ITER divertor

    International Nuclear Information System (INIS)

    Missirlian, M.; Escourbiac, F.; Merola, M.; Durocher, A.; Bobin-Vastra, I.; Schedler, B.

    2007-01-01

    An extensive development programme has been carried out in the EU on high heat flux components within the ITER project. In this framework, a Full Scale Vertical Target (VTFS) prototype was manufactured with all the main features of the corresponding ITER divertor design. The fatigue cycling campaign on CFC and W armoured regions, proved the capability of such a component to meet the ITER requirements in terms of heat flux performances for the vertical target. This paper discusses thermographic examination and thermal fatigue testing results obtained on this component. The study includes thermal analysis, with a tentative proposal to evaluate with finite element approach the location/size of defects and the possible propagation during fatigue cycling

  20. Fabrication of optical fiber micro(and nano)-optical and photonic devices and components, using computer controlled spark thermo-pulling system

    International Nuclear Information System (INIS)

    Fatemi, H.; Mosleh, A.; Pashmkar, M.; Khaksar Kalati, A.

    2007-01-01

    Fabrication of optical fiber Micro (and Nano)-Optical component and devices, as well as, those applicable for photonic purposes are described. It is to demonstrate the practical capabilities and characterization of the previously reported Computer controlled spark thermo-pulling fabrication system.

  1. Fabrication and characterization of UV-emitting nanoparticles as novel radiation sensitizers targeting hypoxic tumor cells

    Science.gov (United States)

    Squillante, Michael R.; Jüstel, Thomas; Anderson, R. Rox; Brecher, Charles; Chartier, Daniel; Christian, James F.; Cicchetti, Nicholas; Espinoza, Sara; McAdams, Daniel R.; Müller, Matthias; Tornifoglio, Brooke; Wang, Yimin; Purschke, Martin

    2018-06-01

    Radiation therapy is one of the primary therapeutic techniques for treating cancer, administered to nearly two-thirds of all cancer patients. Although largely effective in killing cancer cells, radiation therapy, like other forms of cancer treatment, has difficulty dealing with hypoxic regions within solid tumors. The incomplete killing of cancer cells can lead to recurrence and relapse. The research presented here is investigating the enhancement of the efficacy of radiation therapy by using scintillating nanoparticles that emit UV photons. UV photons, with wavelengths between 230 nm and 280 nm, are able to inactivate cells due to their direct interaction with DNA, causing a variety of forms of damage. UV-emitting nanoparticles will enhance the treatment in two ways: first by generating UV photons in the immediate vicinity of cancer cells, leading to direct and oxygen-independent DNA damage, and second by down-converting the applied higher energy X-rays into softer X-rays and particles that are more efficiently absorbed in the targeted tumor region. The end result will be nanoparticles with a higher efficacy in the treatment of hypoxic cells in the tumor, filling an important, unmet clinical need. Our preliminary experiments show an increase in cell death using scintillating LuPO4:Pr nanoparticles over that achieved by the primary radiation alone. This work describes the fabrication of the nanoparticles, their physical characterization, and the spectroscopic characterization of the UV emission. The work also presents in vitro results that demonstrate an enhanced efficacy of cell killing with x-rays and a low unspecific toxicity of the nanoparticles.

  2. The status of ceramic turbine component fabrication and quality assurance relevant to automotive turbine needs

    Energy Technology Data Exchange (ETDEWEB)

    Richerson, D.W.

    2000-02-01

    This report documents a study funded by the U.S. Department of Energy (DOE) Office of Transportation Technologies (OTT) with guidance from the Ceramics Division of the United States Automotive Materials Partnership (USAMP). DOE and the automotive companies have funded extensive development of ceramic materials for automotive gas turbine components, the most recent effort being under the Partnership for a New Generation of Vehicles (PNGV) program.

  3. Fabrication, Quality Assurance, and Quality Control for PROSPECT Detector Component Production

    Science.gov (United States)

    Gustafson, Ian; Prospect (The Precision Reactor Oscillation; Spectrum Experiment) Collaboration

    2017-09-01

    The Precision Reactor Oscillation and Spectrum Experiment (PROSPECT) is an electron antineutrino (νe) detector intended to make a precision measurement of the 235U neutrino spectrum and to search for the possible existence of sterile neutrinos with a mass splitting of Δm2 on the order of 1 eV2 . As a short baseline detector, PROSPECT will be located less than 10 meters from the High Flux Isotope Reactor at Oak Ridge National Laboratory. As PROSPECT intends to search for baseline-dependent oscillations, physical segmentation is needed to better measure the interaction position. PROSPECT will therefore be a segmented detector in two dimensions, thereby improving position measurements. PROSPECT will be segmented into 154 (11×14) 1.2-meter long rectangular tubes, using optical separators. Each separator will consist of a carbon fiber core, laminated with optical reflector (to increase light collection) and Teflon (to ensure compatibility with the scintillator). These optical separators will be held in place via strings of 3D printed PLA rods called `pinwheels.' This poster discusses the fabrication and quality assurance (QA) procedures used in the production of both the PROSPECT optical separators and pinwheels. For the PROSPECT collaboration.

  4. Laser ``M'egajoule'' cryogenic target program: from target fabrication to conformation of the deuterium-tritium ice layer

    Science.gov (United States)

    Collier, Rémy; Durut, Frédéric; Reneaume, Benoît; Chicane, Cédric; Théobald, Marc; Breton, Olivier; Martin, Michel; Fleury, Emmanuel; Vincent-Viry, Olivier; Bachelet, Franck; Jeannot, Laurent; Geoffray, Isabelle; Botrel, Ronan; Dauteuil, Christophe; Hermerel, Cyril; Choux, Alexandre; Bednarczyk, Sophie; Legaie, Olivier

    2008-11-01

    For the French inertial confinement fusion (ICF) experiments, cryogenic target assemblies (CTAs) for the LMJ program are manufactured and filled at CEA Valduc (Dijon) in the cryogenic targets filling station (IRCC). They will be moved at about 20 K into a transport cryostat for cryogenic targets and will be driven from CEA/Valduc to CEA/CESTA (Bordeaux). Cryogenic targets will then be transferred by several cryogenic grippers on the cryogenic target positioner before shots. The CTA has to meet severe specifications and involves a lot of challenging tasks for its manufacture. To fill CTAs by permeation with deuterium-tritium (DT), the IRCC need to meet strict thermal, mechanical and dimensional specifications. To obtain a good combustion yield, a very homogenous DT ice layer and very smooth roughness at 1.5 K below the DT triple point are also required. This paper deals with the up to date main issues in the different fields of the LMJ cryogenic target program.

  5. Fabrication and characterization of powder metallurgy tantalum components prepared by high compaction pressure technique

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Youngmoo [Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141 (Korea, Republic of); Agency for Defense Development, Yuseong, P.O. Box 35, Yuseong-gu, Daejeon 34186, Republic of Korea. (Korea, Republic of); Lee, Dongju [Korea Atomic Energy Research Institute, 111 Daedeok-daero, Yuseong-gu, Daejeon 34057 (Korea, Republic of); Hwang, Jaewon [Samsung Electronics, 129 Samsung-ro, Youngtong-gu, Suwon 16677 (Korea, Republic of); Ryu, Ho Jin, E-mail: hojinryu@kaist.ac.kr [Department of Nuclear and Quantum Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141 (Korea, Republic of); Hong, Soon Hyung, E-mail: shhong@kaist.ac.kr [Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141 (Korea, Republic of)

    2016-04-15

    The present study has investigated the consolidation behaviors of tantalum powders during compaction and sintering, and the characteristics of sintered components. For die compaction, the densification behaviors of the powders are simulated by finite element analyses based on the yield function proposed by Shima and Oyane. Accordingly, the green density distribution for coarser particles is predicted to be more uniform because they exhibits higher initial relative tap density owing to lower interparticle friction. It is also found that cold isostatic pressing is capable of producing higher dense compacts compared to the die pressing. However, unlike the compaction behavior, the sintered density of smaller particles is found to be higher than those of coarser ones owing to their higher specific surface area. The maximum sintered density was found to be 0.96 of theoretical density where smaller particles were pressed isostatically at 400 MPa followed by sintering at 2000 °C. Moreover, the effects of processing conditions on grain size and texture were also investigated. The average grain size of the sintered specimen is 30.29 μm and its texture is less than 2 times random intensity. Consequently, it is concluded that the higher pressure compaction technique is beneficial to produce high dense and texture-free tantalum components compared to hot pressing and spark plasma sintering. - Highlights: • Higher Ta density is obtained from higher pressure and sintering temperature. • High compaction method enables P/M Ta to achieve the density of 16.00 g·cm{sup −3}. • A P/M Ta component with fine microstructure and random orientation is developed.

  6. Report on fabrication of pin components for fuel fabrication in FUJI project (Co-operation in the research and development of advanced sphere-pac fuel among PSI, JNC, and NRG)

    International Nuclear Information System (INIS)

    Suzuki, Masahiro; Hinai, Hiroshi; Shigetome, Yoshiaki; Kono, Shusaku; Matsuzaki, Masaaki

    2003-03-01

    Japan Nuclear Cycle Development Institute (JNC) has conducted the co-operation concerning vibro-packed fuels with Paul Scherrer Institut (PSI) in Switzerland and Nuclear Research and consultancy Group (NRG) in the Netherlands. The project 'Research and Development of advanced Sphere-pac Fuel' is called FUJI (FUel irradiations for JNC and PSI) Project. In this project, three types of fuels that are sphere-pac fuels, vipac fuels, and pellet fuels will be irradiated in the High Flux Reactor (HFR) to compare their performance. Based on the drawing which has been agreed among three parties, fabrication of the pin components and welding of the upper and lower connection end plugs were performed in accordance with ISO9001 in JNC. This report describes data of the fabricated pin components, results of welding qualification tests, and quality assurance of the welded components. The fabrication of pin components was successfully completed and they were delivered to PSI in October 2002. (author)

  7. Fabrication and Characterizations of Materials and Components for Intermediate Temperature Fuel Cells and Water Electrolysers

    DEFF Research Database (Denmark)

    Jensen, Annemette Hindhede; Prag, Carsten Brorson; Li, Qingfeng

    The worldwide development of fuel cells and electrolysers has so far almost exclusively addressed either the low temperature window (20-200 °C) or the high temperature window (600-1000 °C). This work concerns the development of key materials and components of a new generation of fuel cells...... and electrolysers for operation in the intermediate temperature range from 200 to 400 °C. The intermediate temperature interval is of importance for the use of renewable fuels. Furthermore electrode kinetics is significantly enhanced compared to when operating at low temperature. Thus non-noble metal catalysts...... might be used. One of the key materials in the fuel cell and electrolyser systems is the electrolyte. Proton conducting materials such as cesium hydrogen phosphates, zirconium hydrogen phosphates and tin pyrophosphates have been investigated by others and have shown interesting potential....

  8. Transference of know-how for the fabrication of heavy components for nuclear power reactors

    International Nuclear Information System (INIS)

    Meier, F.

    1977-01-01

    1) Heavy components for nuclear power reactors. Reactor pressure vessels with total weight of 540 tons; steam generators: heat exchangers with U-type tube bundles, total weight 420 tons. 2) Choice of know-how recipient. Technical criteria, i.e. manufacturing facilities, existing quality assurance system, location of the workshops, possibilities for training, infrastructures. 3. Measures for transferring know-how to a newly established company. Planning and erection of the factory: organisational set up of the company; personnel selection and training; transfer of documentation; transfer of know-how that cannot be transferred in a written form. 4) Contracts for assuring the transfer of know-how. Stipulation of mutual rights and obligations of the know-how owner and receiver in individual contracts: engineering services contract, technical information contract, personnel training contract, license contract. (orig.) [de

  9. Functionalisation of Ti6Al4V components fabricated using selective laser melting with a bioactive compound

    Energy Technology Data Exchange (ETDEWEB)

    Vaithilingam, Jayasheelan [Additive Manufacturing and 3D Printing Research Group, School of Engineering, The University of Nottingham, Nottingham NG7 2RD (United Kingdom); Kilsby, Samuel [Department of Chemistry, Loughborough University, Loughborough LE11 3TU (United Kingdom); Goodridge, Ruth D., E-mail: Ruth.Goodridge@nottingham.ac.uk [Additive Manufacturing and 3D Printing Research Group, School of Engineering, The University of Nottingham, Nottingham NG7 2RD (United Kingdom); Christie, Steven D.R. [Department of Chemistry, Loughborough University, Loughborough LE11 3TU (United Kingdom); Edmondson, Steve [School of Materials, The University of Manchester, Manchester M13 9PL (United Kingdom); Hague, Richard J.M. [Additive Manufacturing and 3D Printing Research Group, School of Engineering, The University of Nottingham, Nottingham NG7 2RD (United Kingdom)

    2015-01-01

    Surface modification of an implant with a biomolecule is used to improve its biocompatibility and to reduce post-implant complications. In this study, a novel approach has been used to functionalise phosphonic acid monolayers with a drug. Ti6Al4V components fabricated using selective laser melting (SLM) were functionalised with Paracetamol (a pharmaceutically relevant biomolecule) using phosphonic acid based self-assembled monolayers (SAMs). The attachment, stability of the monolayers on the SLM fabricated surface and functionalisation of SAMs with Paracetamol were studied using X-ray photoelectron spectroscopy (XPS) and surface wettability measurements. The obtained results confirmed that SAMs were stable on the Ti6Al4V surface for over four weeks and then began to desorb from the surface. The reaction used to functionalise the phosphonic acid monolayers with Paracetamol was noted to be successful. Thus, the proposed method has the potential to immobilise drugs/proteins to SAM coated surfaces and improve their biocompatibility and reduce post-implant complications. - Graphical abstract: A significant change in the contact angle confirming the immobilisation of Paracetamol. (a) Before self-assembled monolayer (SAM) attachment, (b) after SAM attachment and (c) after the immobilisation of Paracetamol to the SAMs. - Highlights: • Ti6Al4V parts were fabricated using selective laser melting (SLM). • Monolayers used to modify the SLM surface were stable for over 28 days (in-vitro). • Surface roughness did not have a significant impact on the monolayer stability. • Paracetamol was successfully immobilised to the adsorbed monolayers. • Caution required before selecting Paracetamol as a model drug.

  10. Functionalisation of Ti6Al4V components fabricated using selective laser melting with a bioactive compound

    International Nuclear Information System (INIS)

    Vaithilingam, Jayasheelan; Kilsby, Samuel; Goodridge, Ruth D.; Christie, Steven D.R.; Edmondson, Steve; Hague, Richard J.M.

    2015-01-01

    Surface modification of an implant with a biomolecule is used to improve its biocompatibility and to reduce post-implant complications. In this study, a novel approach has been used to functionalise phosphonic acid monolayers with a drug. Ti6Al4V components fabricated using selective laser melting (SLM) were functionalised with Paracetamol (a pharmaceutically relevant biomolecule) using phosphonic acid based self-assembled monolayers (SAMs). The attachment, stability of the monolayers on the SLM fabricated surface and functionalisation of SAMs with Paracetamol were studied using X-ray photoelectron spectroscopy (XPS) and surface wettability measurements. The obtained results confirmed that SAMs were stable on the Ti6Al4V surface for over four weeks and then began to desorb from the surface. The reaction used to functionalise the phosphonic acid monolayers with Paracetamol was noted to be successful. Thus, the proposed method has the potential to immobilise drugs/proteins to SAM coated surfaces and improve their biocompatibility and reduce post-implant complications. - Graphical abstract: A significant change in the contact angle confirming the immobilisation of Paracetamol. (a) Before self-assembled monolayer (SAM) attachment, (b) after SAM attachment and (c) after the immobilisation of Paracetamol to the SAMs. - Highlights: • Ti6Al4V parts were fabricated using selective laser melting (SLM). • Monolayers used to modify the SLM surface were stable for over 28 days (in-vitro). • Surface roughness did not have a significant impact on the monolayer stability. • Paracetamol was successfully immobilised to the adsorbed monolayers. • Caution required before selecting Paracetamol as a model drug

  11. Functionalisation of Ti6Al4V components fabricated using selective laser melting with a bioactive compound.

    Science.gov (United States)

    Vaithilingam, Jayasheelan; Kilsby, Samuel; Goodridge, Ruth D; Christie, Steven D R; Edmondson, Steve; Hague, Richard J M

    2015-01-01

    Surface modification of an implant with a biomolecule is used to improve its biocompatibility and to reduce post-implant complications. In this study, a novel approach has been used to functionalise phosphonic acid monolayers with a drug. Ti6Al4V components fabricated using selective laser melting (SLM) were functionalised with Paracetamol (a pharmaceutically relevant biomolecule) using phosphonic acid based self-assembled monolayers (SAMs). The attachment, stability of the monolayers on the SLM fabricated surface and functionalisation of SAMs with Paracetamol were studied using X-ray photoelectron spectroscopy (XPS) and surface wettability measurements. The obtained results confirmed that SAMs were stable on the Ti6Al4V surface for over four weeks and then began to desorb from the surface. The reaction used to functionalise the phosphonic acid monolayers with Paracetamol was noted to be successful. Thus, the proposed method has the potential to immobilise drugs/proteins to SAM coated surfaces and improve their biocompatibility and reduce post-implant complications. Copyright © 2014. Published by Elsevier B.V.

  12. [Study on liver targeted drug delivery system of the effective anticancer component from Bolbstemma paniculatum].

    Science.gov (United States)

    Sun, Yi-Yi; Ll, Tong-Hui; Tang, Chen-Kang; Zhu, Zi-Ping; Chi, Qun; Hou, Shi-Xiang

    2005-06-01

    To study the liver targeted drug delivery system of TBMS--the effective anticancer component from Bolbstemma paniculatum, and to discuss the system's function of decreasing toxicity. BCA was used as carrier material. The preparation through overall feedback dynamic techniques. The properties of preparation and toxicology were also technology of nanoparticles was optimized studied. Thenanoparticles' targeting in mice vivo was observed with transmission electron microscopy. The function of decreasing toxicity was researched by the XXTX-2000 automatic quantitative analysis management system. D50 was 0.68 microm. Drug-loading rate and entrapment rate were 37.3% and 88.6% respectively. The release in vitro accorded with Weibull equation. The reaching release balance time and the t 1/2 extended 26 times and 19 times respectively comparing with injection. Nanoparticles mainly distributed in liver tissue. Their toxicity to lung and liver was evidently lower than injection. Nanoparticles' LD50 exceeded injection's by 13.5% and their stimulus was much lower than injection. The TBMS can be targeted to liver by liver targeted drug delivery system. At the same time, the problem about the toxicity hindering clinical application could be solved, which lays the foundation for the further studies on TBMS.

  13. Mapping multiple components of malaria risk for improved targeting of elimination interventions.

    Science.gov (United States)

    Cohen, Justin M; Le Menach, Arnaud; Pothin, Emilie; Eisele, Thomas P; Gething, Peter W; Eckhoff, Philip A; Moonen, Bruno; Schapira, Allan; Smith, David L

    2017-11-13

    There is a long history of considering the constituent components of malaria risk and the malaria transmission cycle via the use of mathematical models, yet strategic planning in endemic countries tends not to take full advantage of available disease intelligence to tailor interventions. National malaria programmes typically make operational decisions about where to implement vector control and surveillance activities based upon simple categorizations of annual parasite incidence. With technological advances, an enormous opportunity exists to better target specific malaria interventions to the places where they will have greatest impact by mapping and evaluating metrics related to a variety of risk components, each of which describes a different facet of the transmission cycle. Here, these components and their implications for operational decision-making are reviewed. For each component, related mappable malaria metrics are also described which may be measured and evaluated by malaria programmes seeking to better understand the determinants of malaria risk. Implementing tailored programmes based on knowledge of the heterogeneous distribution of the drivers of malaria transmission rather than only consideration of traditional metrics such as case incidence has the potential to result in substantial improvements in decision-making. As programmes improve their ability to prioritize their available tools to the places where evidence suggests they will be most effective, elimination aspirations may become increasingly feasible.

  14. Fabrication of 121Sb isotopic targets for the study of nuclear high spin features

    Science.gov (United States)

    Devi, K. Rojeeta; Kumar, Suresh; Kumar, Neeraj; Abhilash, S. R.; Kabiraj, D.

    2018-06-01

    Isotopic 121Sb targets with 197Au backing have been prepared by Physical Vapor Deposition (PVD) method using the diffusion pump based coating unit at target laboratory, Inter University Accelerator Centre (IUAC), New Delhi, India. The target thickness was measured by stylus profilo-meter and the purity of the targets was investigated by Energy Dispersive X-ray Analysis (EDXA). One of these targets has been used in an experiment which was performed at IUAC for nuclear structure study through fusion evaporation reaction. The excitation function of the 121Sb(12C, yxnγ) reaction has been performed for energies 58 to 70 MeV in steps of 4 MeV. The experimental results were compared with the calculations of statistical models : PACE4 and CASCADE. The methods adopted to achieve best quality foils and good deposition efficiency are reported in this paper.

  15. Fabrication and characterization of tungsten and graphite based PFC for divertor target elements of ITER like tokamak application

    Energy Technology Data Exchange (ETDEWEB)

    Khirwadkar, S.S., E-mail: sameer@ipr.res.in [Institute For Plasma Research, Bhat, Gandhinagar, Gujarat (India); Singh, K.P.; Patil, Y.; Khan, M.S.; Buch, J.J.U.; Patel, Alpesh; Tripathi, Sudhir [Institute For Plasma Research, Bhat, Gandhinagar, Gujarat (India); Jaman, P.M.; Rangaraj, L.; Divakar, C. [Materials Science Division, National Aerospace Laboratories, CSIR, Bangalore, Karnataka (India)

    2011-10-15

    The development of the fabrication technology of macro-brush configuration of tungsten (W) and carbon (graphite and CFC) plasma facing components (PFCs) for ITER like tokamak application is presented. The fabrication of qualified joint of PFC is a requirement for fusion tokamak. Vacuum brazing method has been employed for joining of W/CuCrZr and C/CuCrZr. Oxygen free high conductivity (OFHC) copper casting on W tiles was performed followed by machining, polishing and ultrasonic cleaning of the samples prior to vacuum brazing. The W/CuCrZr and graphite/CuCrZr based test mockups were vacuum brazed using silver free alloys. The mechanical shear and tensile strengths were evaluated for the W/CuCrZr and graphite/CuCrZr brazed joint samples. The micro-structural examination of the joints showed smooth interface. The details of fabrication and characterization procedure for macro-brush tungsten and carbon based PFC test mockups are presented.

  16. Design and fabrication of a CH/Al dual-layer perturbation target for hydrodynamic instability experiments in ICF

    Energy Technology Data Exchange (ETDEWEB)

    Tang, Jun [Shanghai Key Laboratory of Special Artificial Microstructure Materials and Technology, School of Physics Science and Engineering, Tongji University, Shanghai 200092 (China); Xie, Zhiyong [Shanghai Institute of Laser Plasma, Shanghai 201800 (China); Du, Ai [Shanghai Key Laboratory of Special Artificial Microstructure Materials and Technology, School of Physics Science and Engineering, Tongji University, Shanghai 200092 (China); Ye, Junjian [Shanghai Institute of Laser Plasma, Shanghai 201800 (China); Zhang, Zhihua; Shen, Jun [Shanghai Key Laboratory of Special Artificial Microstructure Materials and Technology, School of Physics Science and Engineering, Tongji University, Shanghai 200092 (China); Zhou, Bin, E-mail: zhoubin863@tongji.edu.cn [Shanghai Key Laboratory of Special Artificial Microstructure Materials and Technology, School of Physics Science and Engineering, Tongji University, Shanghai 200092 (China)

    2014-04-15

    Highlights: • Sinusoidal perturbed Al foil was prepared by single-point diamond turning. • Perturbed Al foil was measured by surface profiler and white light interferometer. • Perturbed Al foil and CH layer adhered with each other via a hot-press process. • Parameters and cross-section of the CH–Al perturbation target was characterized. - Abstract: A polystyrene (CH)/aluminum (Al) dual-layer perturbation target for hydrodynamic instability experiments in inertial confinement fusion (ICF) was designed and fabricated. The target was composed of a perturbed 40 μm Al foil and a CH layer. The detailed fabrication method consisted of four steps. The 40 μm Al foil was first prepared by roll and polish process; the perturbation patterns were then introduced on the surface of the Al foil by the single-point diamond turning (SPDT) technology; the CH layer was prepared via a simple method which called spin-coating process; finally, the CH layer was directly coated on the perturbation surface of Al foil by a hot-press process to avoid the use of a sticker and to eliminate the gaps between the CH layer and the Al foil. The parameters of the target, such as the perturbation wavelength (T) and perturbation amplitude (A), were characterized by a QC-5000 tool microscope, an alpha-step 500 surface profiler and a NT1100 white light interferometer. The results showed that T and A of the target were about 52 μm and 7.34 μm, respectively. Thickness of the Al foil (H1), thickness of the CH layer (H2), and cross-section of the dual-layer target were characterized by a QC-5000 tool microscope and a scanning electron microscope (SEM). H1 and H2 were about 40 μm and 15 μm, respectively, the cross-sectional photographs of the target showed that the CH layer and the Al foil adhered perfectly with each other.

  17. Modern condition and possibilities of development of a moral component in a target orientation of the teenager

    Directory of Open Access Journals (Sweden)

    Shylova Nina Ihorivna

    2016-10-01

    Full Text Available The article considers the basic criteria of a moral component in a target orientation of the teenager, whose level of development being defined through the testing of pupils in Mykolaiv city. The article present the results given by the usage of two techniques, defines the ways and prospects of the further development of a moral component in a target orientation of teenagers.

  18. Phytophthora effector targets a novel component of small RNA pathway in plants to promote infection.

    Science.gov (United States)

    Qiao, Yongli; Shi, Jinxia; Zhai, Yi; Hou, Yingnan; Ma, Wenbo

    2015-05-05

    A broad range of parasites rely on the functions of effector proteins to subvert host immune response and facilitate disease development. The notorious Phytophthora pathogens evolved effectors with RNA silencing suppression activity to promote infection in plant hosts. Here we report that the Phytophthora Suppressor of RNA Silencing 1 (PSR1) can bind to an evolutionarily conserved nuclear protein containing the aspartate-glutamate-alanine-histidine-box RNA helicase domain in plants. This protein, designated PSR1-Interacting Protein 1 (PINP1), regulates the accumulation of both microRNAs and endogenous small interfering RNAs in Arabidopsis. A null mutation of PINP1 causes embryonic lethality, and silencing of PINP1 leads to developmental defects and hypersusceptibility to Phytophthora infection. These phenotypes are reminiscent of transgenic plants expressing PSR1, supporting PINP1 as a direct virulence target of PSR1. We further demonstrate that the localization of the Dicer-like 1 protein complex is impaired in the nucleus of PINP1-silenced or PSR1-expressing cells, indicating that PINP1 may facilitate small RNA processing by affecting the assembly of dicing complexes. A similar function of PINP1 homologous genes in development and immunity was also observed in Nicotiana benthamiana. These findings highlight PINP1 as a previously unidentified component of RNA silencing that regulates distinct classes of small RNAs in plants. Importantly, Phytophthora has evolved effectors to target PINP1 in order to promote infection.

  19. Qualification of high heat flux components: application to target elements of W7-X divertor

    International Nuclear Information System (INIS)

    Missirlian, M; Durocher, A; Grosman, A; Schlosser, J; Boscary, J; Escourbiac, F; Cismondi, F

    2007-01-01

    The development of actively cooled plasma-facing components (PFC) represents one of fusion's most challenging engineering efforts. In this frame, a high-quality bonding between the refractory armour and the heat sink is essential to ensure the heat removal capability and the thermal performances of PFC. Experience gained during manufacturing of Tore Supra actively cooled PFC led to the establishment of a qualification methodology and provided a large experience of acceptance criteria using an active infrared thermography (systeme d'acquisition de traitement infra-rouge, SATIR). This paper presents the application of this qualification process to the W7-X pre-series components, with the objective of assessing and defining workable acceptance criteria that enable reliable predictions of performance at the nominal heat flux requirements in W7-X. Finally, to check the reliability of the non-destructive examination (NDE) method by transient infrared thermography, the newly defined acceptance criteria were applied to W7-X pre-series target elements (batch no. 3). The SATIR results, benchmarked with HHF tests performed on the GLADIS ion beam facility were discussed to assess the ability to detect critical defects at the interface between tiles and heat sink

  20. Fabrication of thin-wall, freestanding inertial confinement fusion targets by chemical vapor deposition

    International Nuclear Information System (INIS)

    Carroll, D.W.; McCreary, W.J.

    1982-01-01

    To meet the requirements for plasma physics experiments in the inertial confinement fusion (ICF) program, chemical vapor deposition (CVD) in fluid beds was used to fabricate freestanding tungsten spheres and cylinders with wall thicknesses less than 5.0 μm. Molybdenum and molybdenum alloy (TZM) mandrels of the desired geometry were suspended in a carrier bed of dense microspheres contained in an induction-heated fluid-bed reactor. The mandrels were free to float randomly through the bed, and using the reaction WF 6 +3H 2 →/sub /KW +6HF, very fine-grained tungsten was deposited onto the surface at a rate and in a grain size determined by temperature, gas flow rate, system pressure, and duration of the reaction. After coating, a portion of each mandrel was exposed by hole drilling or grinding. The mandrel was then removed by acid leaching, leaving a freestanding tungsten shape. Experimental procedures, mandrel preparation, and results obtained are discussed

  1. Overview on the target fabrication facilities at ELI-NP and ongoing strategies

    Science.gov (United States)

    Gheorghiu, C. C.; Leca, V.; Popa, D.; Cernaianu, M. O.; Stutman, D.

    2016-10-01

    Along with the development of petawatt class laser systems, the interaction between high power lasers and matter flourished an extensive research, with high-interest applications like: laser nuclear physics, proton radiography or cancer therapy. The new ELI-NP (Extreme Light Infrastructure - Nuclear Physics) petawatt laser facility, with 10PW and ~ 1023W/cm2 beam intensity, is one of the innovative projects that will provide novel research of fundamental processes during light-matter interaction. As part of the ELI-NP facility, Targets Laboratory will provide the means for in-house manufacturing and characterization of the required targets (mainly solid ones) for the experiments, in addition to the research activity carried out in order to develop novel target designs with improved performances. A description of the Targets Laboratory with the main pieces of equipment and their specifications are presented. Moreover, in view of the latest progress in the target design, one of the proposed strategies for the forthcoming experiments at ELI-NP is also described, namely: ultra-thin patterned foil of diamond-like carbon (DLC) coated with a carbon-based ultra-low density layer. The carbon foam which behaves as a near-critical density plasma, will allow the controlled-shaping of the laser pulse before the main interaction with the solid foil. Particular emphasis will be directed towards the target's design optimization, by simulation tests and tuning the key-properties (thickness/length, spacing, density foam, depth, periodicity etc.) which are expected to have a crucial effect on the laser-matter interaction process.

  2. Interaction of a laser beam with a target. Application to the fabrication of granular superconducting films

    International Nuclear Information System (INIS)

    Desserre, Jacques.

    1974-01-01

    The aim was to prepare a superconductor of high T(c). First are given the different simplified theories (BCS, Mac Millan) whereby the critical temperature of a superconductor can be calculated, with a view to its optimization. A material and a preparation technique were chosen on the basis of these theories. The method uses phenomena which occur during the interaction of a coherent pulsed light beam, emitted by a laser, with the surface of a metallic or nonmetallic target. Different theoretical models of this interaction are proposed. Special attention is paid to complex targets (alloys, compounds) and the construction of a model describing the vaporization of a compound is suggested. By a suitable choice of laser, based on the energy emission profile and the value of the energy supplied, congruent vaporization of the target is possible. The technique was applied to the preparation of thin layers by condensation onto a substrate of the vapor and the plasma emitted during the interaction. The deposits generally have the same structure as the bulk compound used as target while the atomic composition of the film may be slightly different. Thin layers of Ni 3 Mn, CdTe, ZnC, HfC were prepared in this way without treatment of the deposits after condensation. Simultaneous vaporization of the compound ReBe 22 in the bulk state gave filaments made up of small grains (20A), identical in composition with the target. The beryllium α phase (compact hexagonal) was identified but the electron diffraction study showed the existence of several other phases of unknown structure. The superconducting properties changed with time [fr

  3. Fabrication and characterisation of composite targets for the transmutation of actinides

    International Nuclear Information System (INIS)

    Naestren, C.; Haas, D.; Fernandez, A.; Somers, J.

    2006-01-01

    Transmutation of transuranic elements separated from spent fuel is a way to reduce the toxicity of long-lived nuclides in the waste before disposal. Plutonium and the minor actinides (MA) are reintroduced into the fuel cycle for further irradiation and incineration. Currently CERMET fuel forms, in which a ceramic actinide is dispersed in a matrix, are considered for MA transmutation. In a first step, PuO 2 beads are produced by a sol gel method in which a Pu nitrate solution is converted to solid, dust-free, particles. These porous beads are then infiltrated with an americium nitrate solution to the incipient wetness point and calcined to give the (PuAm)O 2 beads, which are blended with a metal matrix and compacted and sintered to form the final fuel pellet. The matrix used is molybdenum due to its high thermal conductivity and low neutron capture cross section, if it is enriched in 92 Mo. In this work, optimization of the bead porosity is investigated to achieve a higher Am content by infiltration. Addition of carbon to the mother solution in the sol gel step increases the bead porosity but it also changes both bead and final fuel pellet microstructure. A surrogate fuel, with cerium simulating the actinides has been fabricated and its mechanical stability and bead characteristics investigated as a function of carbon content and thermal treatment. The characterization of the surrogate fuel by ceramography, density, porosity, bead-quality, etc., is a necessary step in the process optimization, to be transferred to the production of the actinide samples. This process is now at an advanced stage and is being used for the production of fuels for irradiation tests in the Phenix (Futurix) and HFR-Petten (HELIOS) reactors. In parallel, studies on the dissolution of the fuel pellets, with the aim of dissolving the Mo-matrix while keeping the CeO 2 beads intact, have been initiated. Thus, Mo can be recycled for further fuel fabrication either from production scraps or from

  4. Production and characterization of thin 7Li targets fabricated by ion implantation

    International Nuclear Information System (INIS)

    Cruz, J.; Fonseca, M.; Luis, H.; Mateus, R.; Marques, H.; Jesus, A.P.; Ribeiro, J.P.; Teodoro, O.M.N.D.; Rolfs, C.

    2009-01-01

    Very high fluence implantation of 7 Li + ions was used to promote the formation of a thin and high density 7 Li target in the surface region of Al samples. The implanted volume was characterized by particle induced gamma-ray emission, Rutherford backscattering spectrometry, X-ray photoelectron spectroscopy and nuclear reaction analysis, revealing that the implanted surface is a combination of Li 2 CO 3 , metallic lithium, LiOH and C, with almost no Al present. Radiation damage effects by proton beams were studied by observing the evolution of the 7 Li(p, α) 4 He nuclear reaction yield with the accumulated charge, at different proton energies, revealing high stability of the produced Li target.

  5. Explorando o componente inflamatório da esquizofrenia Targeting the inflammatory component of schizophrenia

    Directory of Open Access Journals (Sweden)

    Hassan Rahmoune

    2012-01-01

    Full Text Available A esquizofrenia é uma doença heterogênea caracterizada por um conjunto de manifestações clínicas. Um grande número de estudos ao longo dos últimos 20 anos apontou para anormalidades no sistema imune em pacientes que sofrem dessa condição. Em adição, tem sido mostrado que a psicose e a disfunção cognitiva associadas com a esquizofrenia estão ligadas a doenças autoimunes. Aqui, revisamos a evidência que sugere que um status pró-inflamatório do sistema imune induz sintomas psicopatológicos e pode estar envolvido na fisiopatologia dessa principal doença mental. Também propomos que futuros estudos pré-clínicos e clínicos deveriam levar em conta tais causas predefinidas e o status do componente inflamatório. Estratificação de pacientes e estratégias de medicina personalizadas baseadas no direcionamento ao componente inflamatório da doença poderiam ajudar na redução de sintomas e da progressão da doença. Por fim, isso poderia levar a novos conceitos na identificação de alvos moleculares em esquizofrenia e estratégias de descoberta de drogas.Schizophrenia is a heterogeneous disease characterised by an array of clinical manifestations. A large number of studies over the last 20 years have pointed towards immune system abnormalities in patients suffering from this condition. In addition, the psychosis and cognitive dysfunction associated with schizophrenia have been shown to be linked with autoimmune diseases. Here, we review the evidence, which suggests that a pro-inflammatory status of the immune system induces psychopathologic symptoms and may be involved in the pathophysiology of this major mental illness. We also propose that future preclinical and clinical studies should take such pre-defined causes and the dynamic status of the inflammatory component into account. Patient stratification and personalised medicine strategies based on targeting the inflammatory component of the disease could help in alleviation of

  6. Explorando o componente inflamatório da esquizofrenia Targeting the inflammatory component of schizophrenia

    Directory of Open Access Journals (Sweden)

    Hassan Rahmoune

    2013-01-01

    Full Text Available A esquizofrenia é uma doença heterogênea caracterizada por um conjunto de manifestações clínicas. Um grande número de estudos ao longo dos últimos 20 anos apontou para anormalidades no sistema imune em pacientes que sofrem dessa condição. Em adição, tem sido mostrado que a psicose e a disfunção cognitiva associadas com a esquizofrenia estão ligadas a doenças autoimunes. Aqui, revisamos a evidência que sugere que um status pró-inflamatório do sistema imune induz sintomas psicopatológicos e pode estar envolvido na fisiopatologia dessa principal doença mental. Também propomos que futuros estudos pré-clínicos e clínicos deveriam levar em conta tais causas predefinidas e o status do componente inflamatório. Estratificação de pacientes e estratégias de medicina personalizadas baseadas no direcionamento ao componente inflamatório da doença poderiam ajudar na redução de sintomas e da progressão da doença. Por fim, isso poderia levar a novos conceitos na identificação de alvos moleculares em esquizofrenia e estratégias de descoberta de drogas.Schizophrenia is a heterogeneous disease characterised by an array of clinical manifestations. A large number of studies over the last 20 years have pointed towards immune system abnormalities in patients suffering from this condition. In addition, the psychosis and cognitive dysfunction associated with schizophrenia have been shown to be linked with autoimmune diseases. Here, we review the evidence, which suggests that a pro-inflammatory status of the immune system induces psychopathologic symptoms and may be involved in the pathophysiology of this major mental illness. We also propose that future preclinical and clinical studies should take such pre-defined causes and the dynamic status of the inflammatory component into account. Patient stratification and personalised medicine strategies based on targeting the inflammatory component of the disease could help in alleviation of

  7. TARGETED PRINCIPLE COMPONENT ANALYSIS: A NEW MOTION ARTIFACT CORRECTION APPROACH FOR NEAR-INFRARED SPECTROSCOPY.

    Science.gov (United States)

    Yücel, Meryem A; Selb, Juliette; Cooper, Robert J; Boas, David A

    2014-03-01

    As near-infrared spectroscopy (NIRS) broadens its application area to different age and disease groups, motion artifacts in the NIRS signal due to subject movement is becoming an important challenge. Motion artifacts generally produce signal fluctuations that are larger than physiological NIRS signals, thus it is crucial to correct for them before obtaining an estimate of stimulus evoked hemodynamic responses. There are various methods for correction such as principle component analysis (PCA), wavelet-based filtering and spline interpolation. Here, we introduce a new approach to motion artifact correction, targeted principle component analysis (tPCA), which incorporates a PCA filter only on the segments of data identified as motion artifacts. It is expected that this will overcome the issues of filtering desired signals that plagues standard PCA filtering of entire data sets. We compared the new approach with the most effective motion artifact correction algorithms on a set of data acquired simultaneously with a collodion-fixed probe (low motion artifact content) and a standard Velcro probe (high motion artifact content). Our results show that tPCA gives statistically better results in recovering hemodynamic response function (HRF) as compared to wavelet-based filtering and spline interpolation for the Velcro probe. It results in a significant reduction in mean-squared error (MSE) and significant enhancement in Pearson's correlation coefficient to the true HRF. The collodion-fixed fiber probe with no motion correction performed better than the Velcro probe corrected for motion artifacts in terms of MSE and Pearson's correlation coefficient. Thus, if the experimental study permits, the use of a collodion-fixed fiber probe may be desirable. If the use of a collodion-fixed probe is not feasible, then we suggest the use of tPCA in the processing of motion artifact contaminated data.

  8. TARGETED PRINCIPLE COMPONENT ANALYSIS: A NEW MOTION ARTIFACT CORRECTION APPROACH FOR NEAR-INFRARED SPECTROSCOPY

    Science.gov (United States)

    YÜCEL, MERYEM A.; SELB, JULIETTE; COOPER, ROBERT J.; BOAS, DAVID A.

    2014-01-01

    As near-infrared spectroscopy (NIRS) broadens its application area to different age and disease groups, motion artifacts in the NIRS signal due to subject movement is becoming an important challenge. Motion artifacts generally produce signal fluctuations that are larger than physiological NIRS signals, thus it is crucial to correct for them before obtaining an estimate of stimulus evoked hemodynamic responses. There are various methods for correction such as principle component analysis (PCA), wavelet-based filtering and spline interpolation. Here, we introduce a new approach to motion artifact correction, targeted principle component analysis (tPCA), which incorporates a PCA filter only on the segments of data identified as motion artifacts. It is expected that this will overcome the issues of filtering desired signals that plagues standard PCA filtering of entire data sets. We compared the new approach with the most effective motion artifact correction algorithms on a set of data acquired simultaneously with a collodion-fixed probe (low motion artifact content) and a standard Velcro probe (high motion artifact content). Our results show that tPCA gives statistically better results in recovering hemodynamic response function (HRF) as compared to wavelet-based filtering and spline interpolation for the Velcro probe. It results in a significant reduction in mean-squared error (MSE) and significant enhancement in Pearson’s correlation coefficient to the true HRF. The collodion-fixed fiber probe with no motion correction performed better than the Velcro probe corrected for motion artifacts in terms of MSE and Pearson’s correlation coefficient. Thus, if the experimental study permits, the use of a collodion-fixed fiber probe may be desirable. If the use of a collodion-fixed probe is not feasible, then we suggest the use of tPCA in the processing of motion artifact contaminated data. PMID:25360181

  9. Fabrication of genetically engineered polypeptide@quantum dots hybrid nanogels for targeted imaging

    Science.gov (United States)

    Yang, Jie; Yao, Ming-Hao; Zhao, Dong-Hui; Zhang, Xiao-Shuai; Jin, Rui-Mei; Zhao, Yuan-Di; Liu, Bo

    2017-08-01

    Nanogels have been widely used as multifunctional drug delivery carriers because of high water content, biocompatibility, and high loading capability. We designed and biosynthesized two triblock artificial polypeptides PC10A and PC10ARGD as vehicles for encapsulating hydrophobic materials. These polypeptides can form nanogels by self-assembly when the concentration is below 2% ( w/ v). The physical properties of nanogels, including size, surface potential, and targeting domain, are able to be tuned. Hydrophobic materials from molecular size to nano-size can be loaded into the polypeptide nanogels to form hybrid nanogels. Hydrophobic quantum dots CdSe@ZnS below 10 nM were loaded into the polypeptide nanogels by ultrasonic treatment. Encapsulation endows hydrophobic QDs with good tunability of size, water solubility, stability, targeting, and biocompatibility. PC10ARGD nanogels and PC10ARGD@QDs hybrid nanogels showed excellent biocompatibility, which the cellular viabilities of HeLa and MCF-7 cells treated with 1% PC10ARGD nanogels and PC10ARGD@QDs hybrid nanogels contained 20 nM QDs were above 90 and 80%, respectively. PC10ARGD@QDs hybrid nanogels with an arginine-glycine-aspartic acid motif present efficient receptor-mediated endocytosis in α v β 3 overexpressing HeLa cells but not in the control MCF-7 cells as analyzed by confocal microscopy. These results demonstrate that such polypeptide nanogels as nanocarriers are expected to have great potential applications in biomedicine.

  10. Fabrication and evaluation of tumor-targeted positive MRI contrast agent based on ultrasmall MnO nanoparticles.

    Science.gov (United States)

    Huang, Haitao; Yue, Tao; Xu, Ke; Golzarian, Jafar; Yu, Jiahui; Huang, Jin

    2015-07-01

    Gd(III) chelate is currently used as positive magnetic resonance imaging (MRI) contrast agent in clinical diagnosis, but generally induces the risk of nephrogenic systemic fibrosis (NSF) due to the dissociated Gd(3+) from Gd(III) chelates. To develop a novel positive MRI contrast agent with low toxicity and high sensitivity, ultrasmall MnO nanoparticles were PEGylated via catechol-Mn chelation and conjugated with cRGD as active targeting function to tumor. Particularly, the MnO nanoparticles with a size of ca. 5nm were modified by α,β-poly(aspartic acid)-based graft polymer containing PEG and DOPA moieties and, meanwhile, conjugated with cRGD to produce the contrast agent with a size of ca. 100nm and a longitudinal relaxivity (r1) of 10.2mM(-1)S(-1). Such nanoscaled contrast agent integrated passive- and active-targeting function to tumor, and its efficient accumulation behavior in tumor was verified by in vivo distribution study. At the same time, the PEG moiety played a role of hydrophilic coating to improve the biocompatibility and stability under storing and physiological conditions, and especially might guarantee enough circulation time in blood. Moreover, in vivo MRI revealed a good and long-term effect of enhancing MRI signal for as-fabricated contrast agent while cell viability assay proved its acceptable cytotoxicity for MRI application. On the whole, the as-fabricated PEGylated and cRGD-functionalized contrast agent based on ultrasmall MnO nanoparticles showed a great potential to the T1-weighted MRI diagnosis of tumor. Crown Copyright © 2015. Published by Elsevier B.V. All rights reserved.

  11. Diagnostic radionuclide imaging of amyloid: biological targeting by circulating human serum amyloid P component

    Energy Technology Data Exchange (ETDEWEB)

    Hawkins, P.N.; Lavender, J.P.; Myers, M.J.; Pepys, M.B.

    1988-06-25

    The specific molecular affinity of the normal plasma protein, serum amyloid P component (SAP), for all known types of amyloid fibrils was used to develop a new general diagnostic method for in-vivo radionuclide imaging of amyloid deposits. After intravenous injection of /sup 123/I-labelled purified human SAP there was specific uptake into amyloid deposits in all affected patients, 7 with systematic AL amyloid, 5 with AA amyloid, and 2 with ..beta../sub 2/M amyloid, in contrast to the complete absence of any tissue localisation in 5 control subjects. Distinctive high-resolution scintigraphic images, even of minor deposits in the carpal regions, bone marrow, or adrenals, were obtained. This procedure should yield much information on the natural history and the management of amyloidosis, the presence of which has hitherto been confirmed only by biopsy. Clearance and metabolic studies indicated that, in the presence of extensive amyloidosis, the rate of synthesis of SAP was greatly increased despite maintenance of normal plasma levels. Futhermore, once localised to amyloid deposits the /sup 123/I-SAP persisted for long periods and was apparently protected from its normal rapid degradation. These findings shed new light on the pathophysiology of amyloid and may have implications for therapeutic strategies based upon specific molecular targeting with SAP.

  12. Theoretical and numerical analysis of auxiliary heating for cryogenic target fabrication

    International Nuclear Information System (INIS)

    Yang Xiaohu; Tian Chenglin; Yin Yan; Xu Han; Zhuo Hongbin

    2008-01-01

    In order to compensate for the nonspherical-symmetric heat flux in the hohlraum, auxiliary heating is usually applied to the outside wall of the hohlraum during the cooling process. A one-dimensional heat exchange theoretical model has been proposed in the indirect-drive target, to analyze the required auxiliary heat flux. With a two dimensional axisymmetric model, the auxiliary heating mechanism has been simulated by FLUENT code. The optimum heat flux which is 635 W/m 2 has been obtained as the heaters around the outside of the hohlraum about 1.3 mm above and below the mid-plane. The result is in good agreement with the theoretical model. (authors)

  13. Fabrication of self supporting metallic rare earth targets using a piezo-electric quartz as substrate

    International Nuclear Information System (INIS)

    Bonetti, C.P.

    1975-01-01

    Metallic self-supporting targets of cerium and praseodymium of 1 to 2.5mg/cm 2 on a diameter of 18mm were made using the process of evaporation by electron bombardment. Materials are placed on a piezo-electric quartz which permits the direct and precise measurement of the mass of the deposit. Then, such a deposit must be removed and placed on a frame in an environment of argon gas. This method is important because it can be used for small quantities of materials (case of separated isotopes). These high purity foils are used for the study of (d,n) reactions with the Tandem Van de Graaff Accelerator [fr

  14. A Network Pharmacology Approach to Determine the Active Components and Potential Targets of Curculigo Orchioides in the Treatment of Osteoporosis.

    Science.gov (United States)

    Wang, Nani; Zhao, Guizhi; Zhang, Yang; Wang, Xuping; Zhao, Lisha; Xu, Pingcui; Shou, Dan

    2017-10-27

    BACKGROUND Osteoporosis is a complex bone disorder with a genetic predisposition, and is a cause of health problems worldwide. In China, Curculigo orchioides (CO) has been widely used as a herbal medicine in the prevention and treatment of osteoporosis. However, research on the mechanism of action of CO is still lacking. The aim of this study was to identify the absorbable components, potential targets, and associated treatment pathways of CO using a network pharmacology approach. MATERIAL AND METHODS We explored the chemical components of CO and used the five main principles of drug absorption to identify absorbable components. Targets for the therapeutic actions of CO were obtained from the PharmMapper server database. Pathway enrichment analysis was performed using the Comparative Toxicogenomics Database (CTD). Cytoscape was used to visualize the multiple components-multiple target-multiple pathways-multiple disease network for CO. RESULTS We identified 77 chemical components of CO, of which 32 components could be absorbed in the blood. These potential active components of CO regulated 83 targets and affected 58 pathways. Data analysis showed that the genes for estrogen receptor alpha (ESR1) and beta (ESR2), and the gene for 11 beta-hydroxysteroid dehydrogenase type 1, or cortisone reductase (HSD11B1) were the main targets of CO. Endocrine regulatory factors and factors regulating calcium reabsorption, steroid hormone biosynthesis, and metabolic pathways were related to these main targets and to ten corresponding compounds. CONCLUSIONS The network pharmacology approach used in our study has attempted to explain the mechanisms for the effects of CO in the prevention and treatment of osteoporosis, and provides an alternative approach to the investigation of the effects of this complex compound.

  15. Surface chemistry of Ti6Al4V components fabricated using selective laser melting for biomedical applications

    Energy Technology Data Exchange (ETDEWEB)

    Vaithilingam, Jayasheelan, E-mail: Jayasheelan.Vaithilingam@nottingham.ac.uk [Additive Manufacturing and 3D Printing Research Group, EPSRC Centre for Innovative Manufacturing in Additive Manufacturing, School of Engineering, The University of Nottingham, Nottingham NG7 2RD (United Kingdom); Prina, Elisabetta [School of Pharmacy, Centre for Biomolecular Sciences, The University of Nottingham, Nottingham NG7 2RD (United Kingdom); Goodridge, Ruth D.; Hague, Richard J.M. [Additive Manufacturing and 3D Printing Research Group, EPSRC Centre for Innovative Manufacturing in Additive Manufacturing, School of Engineering, The University of Nottingham, Nottingham NG7 2RD (United Kingdom); Edmondson, Steve [School of Materials, The University of Manchester, Manchester M13 9PL (United Kingdom); Rose, Felicity R.A.J. [School of Pharmacy, Centre for Biomolecular Sciences, The University of Nottingham, Nottingham NG7 2RD (United Kingdom); Christie, Steven D.R. [Department of Chemistry, Loughborough University, Loughborough LE11 3TU (United Kingdom)

    2016-10-01

    Selective laser melting (SLM) has previously been shown to be a viable method for fabricating biomedical implants; however, the surface chemistry of SLM fabricated parts is poorly understood. In this study, X-ray photoelectron spectroscopy (XPS) was used to determine the surface chemistries of (a) SLM as-fabricated (SLM-AF) Ti6Al4V and (b) SLM fabricated and mechanically polished (SLM-MP) Ti6Al4V samples and compared with (c) traditionally manufactured (forged) and mechanically polished Ti6Al4V samples. The SLM–AF surface was observed to be porous with an average surface roughness (Ra) of 17.6 ± 3.7 μm. The surface chemistry of the SLM-AF was significantly different to the FGD-MP surface with respect to elemental distribution and their existence on the outermost surface. Sintered particles on the SLM-AF surface were observed to affect depth profiling of the sample due to a shadowing effect during argon ion sputtering. Surface heterogeneity was observed for all three surfaces; however, vanadium was witnessed only on the mechanically polished (SLM-MP and FGD-MP) surfaces. The direct and indirect 3T3 cell cytotoxicity studies revealed that the cells were viable on the SLM fabricated Ti6Al4V parts. The varied surface chemistry of the SLM-AF and SLM-MP did not influence the cell behaviour. - Highlights: • Surface chemistry of selective laser melted (SLM) Ti6Al4V parts was compared with conventionally forged Ti6Al4V parts. • The surface elemental compositions of the SLM as-fabricated surfaces were significantly different to the forged surface. • Surface oxide-layer of the SLM as-fabricated was thicker than the polished SLM surfaces and the forged Ti6Al4V surfaces.

  16. Surface chemistry of Ti6Al4V components fabricated using selective laser melting for biomedical applications.

    Science.gov (United States)

    Vaithilingam, Jayasheelan; Prina, Elisabetta; Goodridge, Ruth D; Hague, Richard J M; Edmondson, Steve; Rose, Felicity R A J; Christie, Steven D R

    2016-10-01

    Selective laser melting (SLM) has previously been shown to be a viable method for fabricating biomedical implants; however, the surface chemistry of SLM fabricated parts is poorly understood. In this study, X-ray photoelectron spectroscopy (XPS) was used to determine the surface chemistries of (a) SLM as-fabricated (SLM-AF) Ti6Al4V and (b) SLM fabricated and mechanically polished (SLM-MP) Ti6Al4V samples and compared with (c) traditionally manufactured (forged) and mechanically polished Ti6Al4V samples. The SLM-AF surface was observed to be porous with an average surface roughness (Ra) of 17.6±3.7μm. The surface chemistry of the SLM-AF was significantly different to the FGD-MP surface with respect to elemental distribution and their existence on the outermost surface. Sintered particles on the SLM-AF surface were observed to affect depth profiling of the sample due to a shadowing effect during argon ion sputtering. Surface heterogeneity was observed for all three surfaces; however, vanadium was witnessed only on the mechanically polished (SLM-MP and FGD-MP) surfaces. The direct and indirect 3T3 cell cytotoxicity studies revealed that the cells were viable on the SLM fabricated Ti6Al4V parts. The varied surface chemistry of the SLM-AF and SLM-MP did not influence the cell behaviour. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

  17. An Effort to Improve Uranium Foil Target Fabrication Technology by Single Roll Method

    Energy Technology Data Exchange (ETDEWEB)

    Sim, Moon Soo; Lee, Jong Hyeon [Chungnam National University, Daejeon (Korea, Republic of); Kim, Chang Kyu [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2012-05-15

    Technetium-99({sup 99m}Tc) is the most commonly used radioisotope in nuclear medicine for diagnostic procedures. It is produced from the decay of its parent Mo-99, which is sent to the hospital or clinic in the form of a generator. Recently, all of the major providers of Mo-99 have used high-enrichment uranium (HEU) as a target material in a research and test reactor. As a part of a nonproliferation effort, the RERTR program has investigated the production of the fission isotope Mo-99 using low-enrichment uranium(LEU) instead of HEU since 1993, a parent nuclide of {sup 99m}Tc , which is a major isotope for a medical diagnosis. As uranium foils have been produced by the conventional method on a laboratory scale by a repetitive hot-rolling method with significant problems in foil quality, productivity and economic efficiency, attention has shifted to the planar flow casting(PFC) method. In KAERI, many experiments are performed using depleted uranium(DU).

  18. Synthesis of the studies on fuels and transmutation targets (fabrication, design, irradiation damage and dissolution) realized in the framework of the Bataille law

    International Nuclear Information System (INIS)

    Pillon, S.

    2004-12-01

    This document presents the different studied fuels and targets for the transmutation of the minor actinides and of the long life fission products for PWR/EPR and Fast neutron Reactor/EFR of today technology; the results of studies on the behavior under ions irradiation and in experimental nuclear reactor; the knowledge in terms of design, simulation and sizing; the development in terms of fabrication; the knowledge on the dissolution aptitude of these fuels and targets. (A.L.B.)

  19. Fabrication of nano-scaled polymer-derived SiAlCN ceramic components using focused ion beam

    Science.gov (United States)

    Tian, Ye; Shao, Gang; Wang, Xingwei; An, Linan

    2013-09-01

    Fully dense polymer-derived amorphous silicoaluminum carbonitride (SiAlCN) ceramics were synthesized from polysilazane as preceramic precursors followed by a thermal decomposition process. The nanofabrication of amorphous SiAlCN ceramics was implemented with a focused ion beam (FIB). FIB conditions such as the milling rate, the beam current, and the number of passes were considered. It was found that nanopatterns with a feature size of less than 100 nm could be fabricated onto polymer-derived ceramics (PDCs) precisely and quickly. Specific nanostructures of thin walls, nozzle, and gear have been fabricated as demonstrations, indicating that the FIB technique was a promising method to realize nanostructures on PDCs, especially for microelectromechanical system and micro/nano-sensor applications.

  20. Fabrication of nano-scaled polymer-derived SiAlCN ceramic components using focused ion beam

    International Nuclear Information System (INIS)

    Tian, Ye; Wang, Xingwei; Shao, Gang; An, Linan

    2013-01-01

    Fully dense polymer-derived amorphous silicoaluminum carbonitride (SiAlCN) ceramics were synthesized from polysilazane as preceramic precursors followed by a thermal decomposition process. The nanofabrication of amorphous SiAlCN ceramics was implemented with a focused ion beam (FIB). FIB conditions such as the milling rate, the beam current, and the number of passes were considered. It was found that nanopatterns with a feature size of less than 100 nm could be fabricated onto polymer-derived ceramics (PDCs) precisely and quickly. Specific nanostructures of thin walls, nozzle, and gear have been fabricated as demonstrations, indicating that the FIB technique was a promising method to realize nanostructures on PDCs, especially for microelectromechanical system and micro/nano-sensor applications. (paper)

  1. Deep lithography with protons Modelling and predicting the performances of a novel fabrication technology for micro-optical components

    CERN Document Server

    Volckaerts, B; Veretennicoff, I; Thienpont, H

    2002-01-01

    We developed a simulation package that predicts 3D-dose distributions in proton irradiated poly(methylmetacrylate) samples considering primary energy transfer and scattering phenomena. In this paper, we apply this code to predict the surface flatness and maximum thickness of micro-optical and mechanical structures fabricated with deep lithography with protons (DLP). We compare these simulation results with experimental data and highlight the fundamental differences between DLP and deep X-ray lithography.

  2. Method and apparatus from imaging target components in a biological sample using permanent magnets

    NARCIS (Netherlands)

    Tibbe, Arjan G.J.; Terstappen, Leonardus Wendelinus Mathias Marie

    2010-01-01

    The present invention is a method and means for positive selecting and imaging target entities. This includes a coated permanent magnetic device for magnetic manipulation in the system of the present invention. The system immunomagnetically concentrates the target entity, fluorescently labels,

  3. Encapsulation for preservation of functionality and targeted delivery of bioactive food components

    NARCIS (Netherlands)

    de Vos, Paul; Faas, Marijke M.; Spasojevic, Milica; Sikkema, Jan

    There has been a tremendous increase in the number of food products containing bioactive components with a health promoting or disease preventing effect. Bioactive food components can be divided into bioactive molecules and bioactive living cells (probiotics). Both bioactive molecules and bioactive

  4. Structure and properties of nanoparticles fabricated by laser ablation of Zn metal targets in water and ethanol

    Science.gov (United States)

    Svetlichnyi, V. A.; Lapin, I. N.

    2013-10-01

    Size characteristics, structure, and spectral and luminescent properties of nanoparticles fabricated by laser ablation of zinc metal targets in water and ethanol are experimentally investigated upon excitation by Nd:YAG-laser radiation (1064 nm, 7 ns, and 15 Hz). It is demonstrated that zinc oxide nanoparticles with average sizes of 10 nm (in water) and 16 nm (in ethanol) are formed in the initial stage as a result of ablation. The kinetics of the absorption and luminescence spectra, transmission electron microscopy, and x-ray structural analysis demonstrate that during long storage of water dispersions and their drying, nanoparticles efficiently interact with carbon dioxide gas of air that leads to the formation of water-soluble Zn(CO3)2(OH)6. In ethanol, Zn oxidation leads to the formation of stable dispersions of ZnO nanoparticles with 99% of the wurtzite phase; in this case, the fluorescence spectra of ZnO nanoparticles change with time, shifting toward longer wavelength region from 550 to 620 nm, which is caused by the changed nature of defects.

  5. Immobilisation of an antibacterial drug to Ti6Al4V components fabricated using selective laser melting

    Energy Technology Data Exchange (ETDEWEB)

    Vaithilingam, Jayasheelan [Additive Manufacturing and 3D Printing Research Group, School of Engineering, University of Nottingham, Nottingham NG7 2RD (United Kingdom); Kilsby, Samuel [Department of Chemistry, Loughborough University, Loughborough LE11 3TU (United Kingdom); Goodridge, Ruth D., E-mail: Ruth.Goodridge@nottingham.ac.uk [Additive Manufacturing and 3D Printing Research Group, School of Engineering, University of Nottingham, Nottingham NG7 2RD (United Kingdom); Christie, Steven D.R. [Department of Chemistry, Loughborough University, Loughborough LE11 3TU (United Kingdom); Edmondson, Steve [School of Materials, The University of Manchester, Manchester M13 9PL (United Kingdom); Hague, Richard J.M. [Additive Manufacturing and 3D Printing Research Group, School of Engineering, University of Nottingham, Nottingham NG7 2RD (United Kingdom)

    2014-09-30

    Graphical abstract: The potential integration of selective laser melting (SLM) with surface modification using self-assembled monolayers for biomedical application has been investigated. Ciprofloxacin{sup ®} was functionalised to the SLM fabricated Ti6Al4V surface. Sustained release of the drug under in-vitro condition was witnessed. The inhibition zones showed the eluted drug was active against Staphylococcus aureus (a) and Escherichia coli (b) upon its release from the SLM fabricated part. - Highlights: • Parts fabricated using selective laser melting were coated with Ciprofloxacin{sup ®}. • The total amount of drug coated was approximately 1 μg/cm{sup 2}. • The coating was highly stable under oxidative conditions. • In-vitro studies showed a sustained release of the drug for over 42 days. • Ciprofloxacin{sup ®} eluted from the Ti6Al4V surface inhibited bacterial growth. - Abstract: Bacterial infections from biomedical implants and surgical devices are a major problem in orthopaedic, dental and vascular surgery. Although the sources of contaminations that lead to bacterial infections are known, it is not possible to control or avoid such infections completely. In this study, an approach to immobilise Ciprofloxacin{sup ®} (an antibacterial drug) to phosphonic acid based self-assembled monolayers (SAMs) adsorbed on a selectively laser melted (SLM) Ti6Al4V structure, has been presented. X-ray photoelectron spectroscopy (XPS) and static water contact angle measurements confirmed the attachment of SAMs and the drug. Results showed that Ciprofloxacin{sup ®} is highly stable under the oxidative conditions used in this study. In-vitro stability was estimated by immersing the Ciprofloxacin{sup ®} immobilised substrates in 10 mM of Tris–HCl buffer (pH-7.4) for 42 days. The Tris–HCl buffer was analysed using UV–vis spectrophotometry at 7, 14, 28 and 42 day time intervals to determine the release of the immobilised drug. The drug was observed to

  6. Fabrication of aerogel capsule, bromine-doped capsule, and modified gold cone in modified target for the Fast Ignition Realization Experiment (FIREX) Project

    Science.gov (United States)

    Nagai, Keiji; Yang, H.; Norimatsu, T.; Azechi, H.; Belkada, F.; Fujimoto, Y.; Fujimura, T.; Fujioka, K.; Fujioka, S.; Homma, H.; Ito, F.; Iwamoto, A.; Jitsuno, T.; Kaneyasu, Y.; Nakai, M.; Nemoto, N.; Saika, H.; Shimoyama, T.; Suzuki, Y.; Yamanaka, K.; Mima, K.

    2009-09-01

    The development of target fabrication for the Fast Ignition Realization EXperiment (FIREX) Project is described in this paper. For the first stage of the FIREX Project (FIREX-I), the previously designed target has been modified by using a bromine-doped ablator and coating the inner gold cone with a low-density material. A high-quality bromine-doped capsule without vacuoles was fabricated from bromine-doped deuterated polystyrene. The gold surface was coated with a low-density material by electrochemical plating. For the cryogenic fuel target, a brand new type of aerogel material, phloroglucinol/formaldehyde (PF), was investigated and encapsulated to meet the specifications of 500 µm diameter and 20 µm thickness, with 30 nm nanopores. Polystyrene-based low-density materials were investigated and the relationship between the crosslinker content and the nanopore structure was observed.

  7. Quality assurance and design control problems associated with the fabrication and use of spent fuel dry storage components

    International Nuclear Information System (INIS)

    Kobetz, T.J.; Matula, T.O.; Shankman, S.F.

    1999-01-01

    This paper presents the concerns of the staff of the U.S. Nuclear Regulatory Commission (NRC) regarding vendor and utility quality assurance (QA) oversight during the design and fabrication of spent fuel dry storage cask (DSC) systems. Deficient QA and design control programmes have resulted in significant enforcement actions against both vendors and utilities. In addition, the utilities, vendors, and NRC, have expended a considerable amount of resources on resolving these problems. As a result, some utilities have been forced to explore other options for long-term storage of spent fuel, including reracking the spent fuel pool and switching DSC vendors. Some vendors stopped fabricating DSCs until appropriate corrective actions were implemented. This resulted in significant financial and operational burdens on both utilities and vendors. In fiscal years 1996 and 1997, NRC reallocated resources from licensing activities to increased inspection and enforcement activities, thus causing delays in the licensing of new DSC designs. It is imperative that vendors and utilities learn from these mistakes and implement effective QA and DC programmes. (author)

  8. Molecular strategies targeting the host component of cancer to enhance tumor response to radiation therapy

    International Nuclear Information System (INIS)

    Kim, Dong Wook; Huamani, Jessica; Fu, Allie; Hallahan, Dennis E.

    2006-01-01

    The tumor microenvironment, in particular, the tumor vasculature, as an important target for the cytotoxic effects of radiation therapy is an established paradigm for cancer therapy. We review the evidence that the phosphoinositide 3-kinase (PI3K)/Akt pathway is activated in endothelial cells exposed to ionizing radiation (IR) and is a molecular target for the development of novel radiation sensitizing agents. On the basis of this premise, several promising preclinical studies that targeted the inhibition of the PI3K/Akt activation as a potential method of sensitizing the tumor vasculature to the cytotoxic effects of IR have been conducted. An innovative strategy to guide cytotoxic therapy in tumors treated with radiation and PI3K/Akt inhibitors is presented. The evidence supports a need for further investigation of combined-modality therapy that involves radiation therapy and inhibitors of PI3K/Akt pathway as a promising strategy for improving the treatment of patients with cancer

  9. Radioiodinated methylene blue for melanoma targeting: Chemical characterisation and tumour selectivity of labelled components

    International Nuclear Information System (INIS)

    Blower, Philip J.; Clark, Katherine; Link, Eva M.

    1997-01-01

    Radioiodinated methylene blue contains a mixture of components showing selective uptake in human pigmented melanoma, and it has potential for imaging and therapy. Nuclear magnetic resonance and mass spectroscopic studies show that the majority of the radioactivity (85%) is in the form of monoiodinated methylene blue, 4-iodo-3-methylamino-7-dimethylaminophenaza thionium chloride. The amino group ortho-to iodine has become demethylated to a mono-methylamino group. The remainder (15%) of the mixture is the doubly labelled 4,5-diiodo-3,7-bis(methylamino) phenazathionium chloride. The separated components show similar tumour selectivity in athymic mice bearing human pigmented melanomas

  10. Three techniques for the fabrication of high precision, mm-sized metal components based on two-photon lithography, applied for manufacturing horn antennas for THz transceivers

    Science.gov (United States)

    Standaert, Alexander; Brancato, Luigi; Lips, Bram; Ceyssens, Frederik; Puers, Robert; Reynaert, Patrick

    2018-03-01

    This paper proposes a novel packaging solution which integrates micro-machined 3D horn antennas with millimeter-wave and THz tranceivers. This packaging solution is shown to be a valid competitor to existing technologies like metallic split-block waveguides and low temperature cofired ceramics. Three different fabrication methods based on two-photon lithography are presented to form the horn antennas. The first uses two-photon lithography to form the bulk of the antenna. This structure is then metalised through physical vapor deposition (PVD) and copper plating. The second fabrication method makes use of a soft polydimethylsiloxane (PDMS) mold to easily replicate structures and the third method forms the horn antenna through electroforming. A prototype is accurately positioned on top of a 400 GHz 28 nm CMOS transmitter and glued in place with epoxy, thus providing a fully packaged solution. Measurement results show a 12 dB increase in the antenna gain when using the packaged solution. The fabrication processes are not limited to horn antennas alone and can be used to form a wide range of mm-sized metal components.

  11. Fabrication and Characterization of Targets for Shock Propagation and Radiation Burnthrough Measurements on Be-0.9 AT. % Cu Alloy

    International Nuclear Information System (INIS)

    Nobile, A.; Dropinski, S.C.; Edwards, J.M.; Rivera, G.; Margevicius, R.W.; Sebring, R.J.; Olson, R. E.; Tanner, D.L.

    2004-01-01

    Beryllium-copper alloy (Be0.9%Cu) ICF capsules are being developed for the pursuit of thermonuclear ignition at the National Ignition Facility (NIF). Success of this capsule material requires that its shock propagation and radiation burnthrough characteristics be accurately understood. To this end, experiments are being conducted to measure the shock propagation and radiation burnthrough properties of Be0.9%Cu alloy. These experiments involve measurements on small Be0.9%Cu wedge, step and flat samples. Samples are mounted on 1.6-mm-diameter x 1.2-mm-length hohlraums that are illuminated by the OMEGA laser at the University of Rochester. X-rays produced by the hohlraum drive the sample. A streaked optical pyrometer detects breakout of the shock produced by the X-ray pulse. In this paper we describe synthesis of the alloy material, fabrication and characterization of samples, and assembly of the targets. Samples were produced from Be0.9%Cu alloy that was synthesized by hot isostatic pressing of Be powder and copper flake. Samples were 850 μm diameter disks with varying thickness in the case of wedge and step samples, and uniform thickness in the case of flat samples. Sample thickness varied in the range 10-90 μm. Samples were prepared by precision lathe machining and electric discharge machining. The samples were characterized by a Veeco white light interferometer and an optical thickness measurement device that simultaneously measured the upper and lower surface contours of samples using two confocal laser probes. Several campaigns with these samples have been conducted over the past two years

  12. Micro-EDM process modeling and machining approaches for minimum tool electrode wear for fabrication of biocompatible micro-components

    DEFF Research Database (Denmark)

    Puthumana, Govindan

    2017-01-01

    Micro-electrical discharge machining (micro-EDM) is a potential non-contact method for fabrication of biocompatible micro devices. This paper presents an attempt to model the tool electrode wear in micro-EDM process using multiple linear regression analysis (MLRA) and artificial neural networks...... linear regression model was developed for prediction of TWR in ten steps at a significance level of 90%. The optimum architecture of the ANN was obtained with 7 hidden layers at an R-sq value of 0.98. The predicted values of TWR using ANN matched well with the practically measured and calculated values...... (ANN). The governing micro-EDM factors chosen for this investigation were: voltage (V), current (I), pulse on time (Ton) and pulse frequency (f). The proposed predictive models generate a functional correlation between the tool electrode wear rate (TWR) and the governing micro-EDM factors. A multiple...

  13. Double Bounce Component in Cross-Polarimetric SAR from a New Scattering Target Decomposition

    Science.gov (United States)

    Hong, Sang-Hoon; Wdowinski, Shimon

    2013-08-01

    Common vegetation scattering theories assume that the Synthetic Aperture Radar (SAR) cross-polarization (cross-pol) signal represents solely volume scattering. We found this assumption incorrect based on SAR phase measurements acquired over the south Florida Everglades wetlands indicating that the cross-pol radar signal often samples the water surface beneath the vegetation. Based on these new observations, we propose that the cross-pol measurement consists of both volume scattering and double bounce components. The simplest multi-bounce scattering mechanism that generates cross-pol signal occurs by rotated dihedrals. Thus, we use the rotated dihedral mechanism with probability density function to revise some of the vegetation scattering theories and develop a three- component decomposition algorithm with single bounce, double bounce from both co-pol and cross-pol, and volume scattering components. We applied the new decomposition analysis to both urban and rural environments using Radarsat-2 quad-pol datasets. The decomposition of the San Francisco's urban area shows higher double bounce scattering and reduced volume scattering compared to other common three-component decomposition. The decomposition of the rural Everglades area shows that the relations between volume and cross-pol double bounce depend on the vegetation density. The new decomposition can be useful to better understand vegetation scattering behavior over the various surfaces and the estimation of above ground biomass using SAR observations.

  14. Outer membrane targeting of Pseudomonas aeruginosa proteins shows variable dependence on the components of Bam and Lol machineries.

    Science.gov (United States)

    Hoang, Hanh H; Nickerson, Nicholas N; Lee, Vincent T; Kazimirova, Anastasia; Chami, Mohamed; Pugsley, Anthony P; Lory, Stephen

    2011-01-01

    In Gram-negative bacteria, the Lol and Bam machineries direct the targeting of lipidated and nonlipidated proteins, respectively, to the outer membrane (OM). Using Pseudomonas aeruginosa strains with depleted levels of specific Bam and Lol proteins, we demonstrated a variable dependence of different OM proteins on these targeting pathways. Reduction in the level of BamA significantly affected the ability of the β-barrel membrane protein OprF to localize to the OM, while the targeting of three secretins that are functionally related OM proteins was less affected (PilQ and PscC) or not at all affected (XcpQ). Depletion of LolB affected all lipoproteins examined and had a variable effect on the nonlipidated proteins. While the levels of OprF, PilQ, and PscC were significantly reduced by LolB depletion, XcpQ was unaffected and was correctly localized to the OM. These results suggest that certain β-barrel proteins such as OprF primarily utilize the complete Bam machinery. The Lol machinery participates in the OM targeting of secretins to variable degrees, likely through its involvement in the assembly of lipidated Bam components. XcpQ, but not PilQ or PscC, was shown to assemble spontaneously into liposomes as multimers. This work raises the possibility that there is a gradient of utilization of Bam and Lol insertion and targeting machineries. Structural features of individual proteins, including their β-barrel content, may determine the propensity of these proteins for folding (or misfolding) during periplasmic transit and OM insertion, thereby influencing the extent of utilization of the Bam targeting machinery, respectively. Targeting of lipidated and nonlipidated proteins to the outer membrane (OM) compartment in Gram-negative bacteria involves the transfer across the periplasm utilizing the Lol and Bam machineries, respectively. We show that depletion of Bam and Lol components in Pseudomonas aeruginosa does not lead to a general OM protein translocation defect

  15. Pulsed laser deposition of chalcogenide sulfides from multi- and single-component targets: the non-stoichiometric material transfer

    DEFF Research Database (Denmark)

    Schou, Jørgen; Ganskukh, Mungunshagai; Ettlinger, Rebecca Bolt

    2018-01-01

    The mass transfer from target to films is incongruent for chalcogenide sulfides in contrast to the expectations of pulsed laser deposition (PLD) as a stoichiometric film growth process. Films produced from a CZTS (Cu2ZnSnS4) multi-component target have no Cu below a fluence threshold of 0.2 J/cm2......, and the Cu content is also very low at low fluence from a single-component target. Above this threshold, the Cu content in the films increases almost linearly up to a value above the stoichiometric value, while the ratio of the concentration of the other metals Zn to Sn (Zn/Sn) remains constant. Films...... of a similar material CTS (Cu2SnS3) have been produced by PLD from a CTS target and exhibits a similar trend in the same fluence region. The results are discussed on the basis of solid-state data and the existing data from the literature....

  16. Identification of the feedforward component in manual control with predictable target signals.

    Science.gov (United States)

    Drop, Frank M; Pool, Daan M; Damveld, Herman J; van Paassen, Marinus M; Mulder, Max

    2013-12-01

    In the manual control of a dynamic system, the human controller (HC) often follows a visible and predictable reference path. Compared with a purely feedback control strategy, performance can be improved by making use of this knowledge of the reference. The operator could effectively introduce feedforward control in conjunction with a feedback path to compensate for errors, as hypothesized in literature. However, feedforward behavior has never been identified from experimental data, nor have the hypothesized models been validated. This paper investigates human control behavior in pursuit tracking of a predictable reference signal while being perturbed by a quasi-random multisine disturbance signal. An experiment was done in which the relative strength of the target and disturbance signals were systematically varied. The anticipated changes in control behavior were studied by means of an ARX model analysis and by fitting three parametric HC models: two different feedback models and a combined feedforward and feedback model. The ARX analysis shows that the experiment participants employed control action on both the error and the target signal. The control action on the target was similar to the inverse of the system dynamics. Model fits show that this behavior can be modeled best by the combined feedforward and feedback model.

  17. Immobilisation of an antibacterial drug to Ti6Al4V components fabricated using selective laser melting

    Science.gov (United States)

    Vaithilingam, Jayasheelan; Kilsby, Samuel; Goodridge, Ruth D.; Christie, Steven D. R.; Edmondson, Steve; Hague, Richard J. M.

    2014-09-01

    Bacterial infections from biomedical implants and surgical devices are a major problem in orthopaedic, dental and vascular surgery. Although the sources of contaminations that lead to bacterial infections are known, it is not possible to control or avoid such infections completely. In this study, an approach to immobilise Ciprofloxacin® (an antibacterial drug) to phosphonic acid based self-assembled monolayers (SAMs) adsorbed on a selectively laser melted (SLM) Ti6Al4V structure, has been presented. X-ray photoelectron spectroscopy (XPS) and static water contact angle measurements confirmed the attachment of SAMs and the drug. Results showed that Ciprofloxacin® is highly stable under the oxidative conditions used in this study. In-vitro stability was estimated by immersing the Ciprofloxacin® immobilised substrates in 10 mM of Tris-HCl buffer (pH-7.4) for 42 days. The Tris-HCl buffer was analysed using UV-vis spectrophotometry at 7, 14, 28 and 42 day time intervals to determine the release of the immobilised drug. The drug was observed to release in a sustained manner. 50% of the drug was released after 4 weeks with approximately 40% of the drug remaining after 6 weeks. Antibacterial susceptibility tests revealed that the immobilised drug was therapeutically active upon its release. This study demonstrates the potential to use self-assembled monolayers to modify SLM fabricated surfaces with therapeutics.

  18. Design and fabrication of circular and rectangular components for electron-cyclotron-resonant heating of tandem mirror experiment-upgrade

    International Nuclear Information System (INIS)

    Felker, B.; Calderon, M.O.; Chargin, A.K.

    1983-01-01

    The electron-cyclotron-resonant heating (ECRH) systems of rectangular waveguides on Tandem Mirror Experiment-Upgrade (TMX-U) operated with a overall efficiency of 50%, each system using a 28-GHz, 200-kW pulsed gyrotron. We designed and built four circular-waveguide systems with greater efficiency and greater power-handling capabilities to replace the rectangular waveguides. Two of these circular systems, at the 5-kG second-harmonic heating locations, have a total transmission efficiency of >90%. The two systems at the 10-kG fundamental heating locations have a total transmission efficiency of 80%. The difference in efficiency is due to the additional components required to launch the microwaves in the desired orientation and polarization with respect to magnetic-field lines at the 10-kG points. These systems handle the total power available from each gyrotron but do not have the arcing limitation problem of the rectangular waveguide. Each system requires several complex components. The overall physical layout and the design considerations for the rectangular and circular waveguide components are described here

  19. Design and fabrication of circular and rectangular components for electron-cyclotron-resonant heating of tandem mirror experiment-upgrade

    Energy Technology Data Exchange (ETDEWEB)

    Felker, B.; Calderon, M.O.; Chargin, A.K.; Coffield, F.E.; Lang, D.D.; Rubert, R.R.; Pedrotti, L.R.; Stallard, B.W.; Gallagher, N.C. Jr.; Sweeney, D.W.

    1983-11-18

    The electron-cyclotron-resonant heating (ECRH) systems of rectangular waveguides on Tandem Mirror Experiment-Upgrade (TMX-U) operated with a overall efficiency of 50%, each system using a 28-GHz, 200-kW pulsed gyrotron. We designed and built four circular-waveguide systems with greater efficiency and greater power-handling capabilities to replace the rectangular waveguides. Two of these circular systems, at the 5-kG second-harmonic heating locations, have a total transmission efficiency of >90%. The two systems at the 10-kG fundamental heating locations have a total transmission efficiency of 80%. The difference in efficiency is due to the additional components required to launch the microwaves in the desired orientation and polarization with respect to magnetic-field lines at the 10-kG points. These systems handle the total power available from each gyrotron but do not have the arcing limitation problem of the rectangular waveguide. Each system requires several complex components. The overall physical layout and the design considerations for the rectangular and circular waveguide components are described here.

  20. Development of and verification test integral reactor major components - Development of manufacturing process and fabrication of prototype for SG and CEDM

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Chang Hee; Park, Hwa Kyu; Kim, Yong Kyu; Choi, Yong Soon; Kang, Ki Su; Hyun, Young Min [Korea Heavy Industries and Construction Co., LTD., Changwon (Korea)

    1999-03-01

    Integral SMART(System integrated Modular Advanced Reactor) type reactor is under conceptual design. Because major components is integrated within in a single pressure vessel, compact design using advanced technology is essential. It means that manufacturing process for these components is more complex and difficult. The objective of this study is to confirm the possibility of manufacture of Steam Generator, Control Element Drive Mechanism(CEDM) and Reactor Assembly which includes Reactor Pressure Vessel, it is important to understand the design requirement and function of the major components. After understanding the design requirement and function, it is concluded that the helical bending and weld qualification of titanium tube for Steam Generator and the applicability of electron beam weld for CEDM step motor parts is the critical to fabricate the components. Therefore, bending mock-up and weld qualification of titanium tube was performed and the results are quite satisfactory. Also, it is concluded that electron beam welding technique can be applicable to the CEDM step motor part. (author). 22 refs., 14 figs., 46 tabs.

  1. Effect of positively charged particles on sputtering damage of organic electro-luminescent diodes with Mg:Ag alloy electrodes fabricated by facing target sputtering

    Directory of Open Access Journals (Sweden)

    Kouji Suemori

    2017-04-01

    Full Text Available We investigated the influence of the positively charged particles generated during sputtering on the performances of organic light-emitting diodes (OLEDs with Mg:Ag alloy electrodes fabricated by sputtering. The number of positively charged particles increased by several orders of magnitude when the target current was increased from 0.1 A to 2.5 A. When a high target current was used, many positively charged particles with energies higher than the bond energy of single C–C bonds, which are typically found in organic molecules, were generated. In this situation, we observed serious OLED performance degradation. On the other hand, when a low target current was used, OLED performance degradation was not observed when the number of positively charged particles colliding with the organic underlayer increased. We concluded that sputtering damage caused by positively charged particles can be avoided by using a low target current.

  2. Explosion bonding of dissimilar materials for fabricating APS front end components: Analysis of metallurgical and mechanical properties and UHV applications

    International Nuclear Information System (INIS)

    Li, Yuheng; Shu, Deming; Kuzay, T.M.

    1994-01-01

    The front end beamline section contains photon shutters and fixed masks. These components are made of OFHC copper and GlidCOP AL-15. Stainless steels (304 or 316) are also used for connecting photon shutters and fixed masks to other components that operate in the ultrahigh vacuum system. All these dissimilar materials need to be joined together. However, bonding these dissimilar materials is very difficult because of their different mechanical and thermal properties and incompatible metallurgical properties. Explosion bonding is a bonding method in which the controlled energy of a detonating explosive is used to create a metallurgical bond between two or more similar or dissimilar materials. No intermediate filler metal, for example, a brazing compound or soldering alloy, is needed to promote bonding, and no external heat need be applied. A study of the metallurgical and mechanical properties and YGV applications of GlidCop AL-15, OFHC copper, and 304 stainless steel explosion-bonded joints has been done. This report contains five parts: an ultrasonic examination of explosion-bonded joints and a standard setup; mechanical-property and thermal-cycle tests of GlidCop AL-15/304 stainless steel explosion-bonded joints; leak tests of a GlidCop AL-15/304 stainless steel explosion-bonded interfaces for UHV application; metallurgical examination of explosion-bonded interfaces and failure analysis, and discussion and conclusion

  3. Targeting and Assembly of Components of the TOC Protein Import Complex at the Chloroplast Outer Envelope Membrane

    Directory of Open Access Journals (Sweden)

    Lynn G.L. Richardson

    2014-06-01

    Full Text Available The translocon at the outer envelope membrane of chloroplasts (TOC initiates the import of thousands of nuclear encoded preproteins required for chloroplast biogenesis and function. The multimeric TOC complex contains two GTP-regulated receptors, Toc34 and Toc159, which recognize the transit peptides of preproteins and initiate protein import through a β–barrel membrane channel, Toc75. Different isoforms of Toc34 and Toc159 assemble with Toc75 to form structurally and functionally diverse translocons, and the composition and levels of TOC translocons is required for the import of specific subsets of coordinately expressed proteins during plant growth and development. Consequently, the proper assembly of the TOC complexes is key to ensuring organelle homeostasis. This review will focus on our current knowledge of the targeting and assembly of TOC components to form functional translocons at the outer membrane. Our analyses reveal that the targeting of TOC components involves elements common to the targeting of other outer membrane proteins, but also include unique features that appear to have evolved to specifically facilitate assembly of the import apparatus.

  4. Targeting and assembly of components of the TOC protein import complex at the chloroplast outer envelope membrane.

    Science.gov (United States)

    Richardson, Lynn G L; Paila, Yamuna D; Siman, Steven R; Chen, Yi; Smith, Matthew D; Schnell, Danny J

    2014-01-01

    The translocon at the outer envelope membrane of chloroplasts (TOC) initiates the import of thousands of nuclear encoded preproteins required for chloroplast biogenesis and function. The multimeric TOC complex contains two GTP-regulated receptors, Toc34 and Toc159, which recognize the transit peptides of preproteins and initiate protein import through a β-barrel membrane channel, Toc75. Different isoforms of Toc34 and Toc159 assemble with Toc75 to form structurally and functionally diverse translocons, and the composition and levels of TOC translocons is required for the import of specific subsets of coordinately expressed proteins during plant growth and development. Consequently, the proper assembly of the TOC complexes is key to ensuring organelle homeostasis. This review will focus on our current knowledge of the targeting and assembly of TOC components to form functional translocons at the outer membrane. Our analyses reveal that the targeting of TOC components involves elements common to the targeting of other outer membrane proteins, but also include unique features that appear to have evolved to specifically facilitate assembly of the import apparatus.

  5. 3D Microstructural Architectures for Metal and Alloy Components Fabricated by 3D Printing/Additive Manufacturing Technologies

    Science.gov (United States)

    Martinez, E.; Murr, L. E.; Amato, K. N.; Hernandez, J.; Shindo, P. W.; Gaytan, S. M.; Ramirez, D. A.; Medina, F.; Wicker, R. B.

    The layer-by-layer building of monolithic, 3D metal components from selectively melted powder layers using laser or electron beams is a novel form of 3D printing or additive manufacturing. Microstructures created in these 3D products can involve novel, directional solidification structures which can include crystallographically oriented grains containing columnar arrays of precipitates characteristic of a microstructural architecture. These microstructural architectures are advantageously rendered in 3D image constructions involving light optical microscopy and scanning and transmission electron microscopy observations. Microstructural evolution can also be effectively examined through 3D image sequences which, along with x-ray diffraction (XRD) analysis in the x-y and x-z planes, can effectively characterize related crystallographic/texture variances. This paper compares 3D microstructural architectures in Co-base and Ni-base superalloys, columnar martensitic grain structures in 17-4 PH alloy, and columnar copper oxides and dislocation arrays in copper.

  6. Research and development on process components for hydrogen production. (1) Test-fabrication of sulfuric acid transfer pump

    International Nuclear Information System (INIS)

    Iwatsuki, Jin; Terada, Atsuhiko; Hino, Ryutaro; Kubo, Shinji; Onuki, Kaoru; Watanabe, Yutaka

    2009-01-01

    Japan Atomic Energy Agency has been conducting a research and development on hydrogen production system using High Temperature Gas-Cooled Reactor. As a part of this effort, thermochemical water-splitting cycle featuring iodine- and sulfur-compounds (IS process) is under development considering its potential of large-scale economical hydrogen production. The IS process constitutes very severe environments to the materials of construction because of the corrosive nature of process chemicals, especially of the high temperature acidic solutions of sulfuric acid and hydriodic acid dissolving iodine. Therefore, selection of the corrosion-resistant materials and development of the components have been the crucial subjects of process development. This paper concerns the sulfuric acid transfer pump. The development has been implemented of a pump for transporting concentrated sulfuric acid at temperatures of higher than 300degC and at elevated pressure. Recent progress of these activities will be reported. (author)

  7. STRUCTURAL DESIGN CRITERIA FOR TARGET/BLANKET SYSTEM COMPONENT MATERIALS FOR THE ACCELERATOR PRODUCTION OF TRITIUM PROJECT

    Energy Technology Data Exchange (ETDEWEB)

    W. JOHNSON; R. RYDER; P. RITTENHOUSE

    2001-01-01

    The design of target/blanket system components for the Accelerator Production of Tritium (APT) plant is dependent on the development of materials properties data specified by the designer. These data are needed to verify that component designs are adequate. The adequacy of the data will be related to safety, performance, and economic considerations, and to other requirements that may be deemed necessary by customers and regulatory bodies. The data required may already be in existence, as in the open technical literature, or may need to be generated, as is often the case for the design of new systems operating under relatively unique conditions. The designers' starting point for design data needs is generally some form of design criteria used in conjunction with a specified set of loading conditions and associated performance requirements. Most criteria are aimed at verifying the structural adequacy of the component, and often take the form of national or international standards such as the ASME Boiler and Pressure Vessel Code (ASME B and PV Code) or the French Nuclear Structural Requirements (RCC-MR). Whether or not there are specific design data needs associated with the use of these design criteria will largely depend on the uniqueness of the conditions of operation of the component. A component designed in accordance with the ASME B and PV Code, where no unusual environmental conditions exist, will utilize well-documented, statistically-evaluated developed in conjunction with the Code, and will not be likely to have any design data needs. On the other hand, a component to be designed to operate under unique APT conditions, is likely to have significant design data needs. Such a component is also likely to require special design criteria for verification of its structural adequacy, specifically accounting for changes in materials properties which may occur during exposure in the service environment. In such a situation it is common for the design criteria

  8. [Analysis on "component-target-pathway" of Paeonia lactiflora in treating cardiac diseases based on data mining].

    Science.gov (United States)

    Liu, Yang; Zhang, Fang-Bo; Tang, Shi-Huan; Wang, Ping; Li, Sen; Su, Jin; Zhou, Rong-Rong; Zhang, Jia-Qi; Sun, Hui-Feng

    2018-04-01

    Based on the literature review and modern application of Paeonia lactiflora in heart diseases, this article would predict the target of drug and disease by intergrative pharmacology platform of traditional Chinese medicine (TCMIP, http://www.tcmip.cn), and then explore the molecular mechanism of P. lactiflora in treatment of heart disease, providing theoretical basis and method for further studies on P. lactiflora. According to the ancient books, P. lactiflora with functions of "removing the vascular obstruction, removing the lumps, relieving pain, diuretic, nutrient qi" and other effects, have been used for many times to treat heart disease. Some prescriptions are also favored by the modern physicians nowadays. With the development of science, the chemical components that play a role in heart disease and the interrelation between these components and the body become the research hotspot. In order to further reveal the pharmacological substance base and molecular mechanism of P. lactiflora for the treatment of such diseases, TCM-IP was used to obtain multiple molecular targets and signaling pathways in treatment of heart disease. ATP1A1, a common target of drug and disease, was related to energy, and HDAC2 mainly regulated cardiomyocyte hypertrophy gene and cardiomyocyte expression. Other main drug targets such as GCK, CHUK and PRKAA2 indirectly regulated heart disease through many pathways; multiple disease-associated signaling pathways interfered with various heart diseases including coronary heart disease, myocardial ischemia and myocardial hypertrophy through influencing energy metabolism, enzyme activity and gene expression. In conclusion, P. lactiflora plays a role in protecting heart function by regulating the gene expression of cardiomyocytes directly. Meanwhile, it can indirectly intervene in other pathways of heart function, and thus participate in the treatment of heart disease. In this paper, the molecular mechanism of P. lactiflora for treatment of

  9. Fabrication processes of C/Sic composites for high temperature components in energy systems and investigation of their oxidation behavior

    International Nuclear Information System (INIS)

    El-Hakim, E.

    2004-01-01

    Carbon fibre-reinforced ceramic matrix composite are promising candidate materials for high temperature applications such as structural components in energy systems, fusion reactors and advanced gas turbine engines. C/C composites has low oxidation resistance at temperatures above 500degree. To overcome this low oxidation resistance a coating should be applied. Tenax HTA 5131 carbon fibres impregnated with phenolic resin and reinforced silicon carbide were modified by the addition of a coating layer of boron oxide, (suspended in Dyansil-40) for improving anti-oxidation properties of the composites.The oxidation behavior of carbon-silicon carbide composites coated with B 2 O 3 , as an protective layer former, in dry air has been studied in the temperature range 800- 1000 degree for 8 hrs and 16 hrs. The results show that the oxidation rates of the uncoated composites samples are higher than those of the coated composites. The uncoated samples exhibit the highest oxidation rate during the initial stages of oxidation. The composite coated with B 2 O 3 had a significantly improved oxidation resistance due to the formation of a barrier layer for oxygen diffusion. This improvement in the oxidation resistance is attributed to the blocking of the active sites for oxygen diffusion. The oxidation resistance of the coated composite is highly improved; the weight loss percentage of casted samples is 4.5-16% after 16-hrs oxidation in air while the weight loss of uncoated samples is about 60%. The results are supported by scanning electron microscopy

  10. Preliminary construction of integral analysis for characteristic components in complex matrices by in-house fabricated solid-phase microextraction fibers combined with gas chromatography-mass spectrometry.

    Science.gov (United States)

    Tang, Zhentao; Hou, Wenqian; Liu, Xiuming; Wang, Mingfeng; Duan, Yixiang

    2016-08-26

    Integral analysis plays an important role in study and quality control of substances with complex matrices in our daily life. As the preliminary construction of integral analysis of substances with complex matrices, developing a relatively comprehensive and sensitive methodology might offer more informative and reliable characteristic components. Flavoring mixtures belonging to the representatives of substances with complex matrices have now been widely used in various fields. To better study and control the quality of flavoring mixtures as additives in food industry, an in-house fabricated solid-phase microextraction (SPME) fiber was prepared based on sol-gel technology in this work. The active organic component of the fiber coating was multi-walled carbon nanotubes (MWCNTs) functionalized with hydroxyl-terminated polydimethyldiphenylsiloxane, which integrate the non-polar and polar chains of both materials. In this way, more sensitive extraction capability for a wider range of compounds can be obtained in comparison with commercial SPME fibers. Preliminarily integral analysis of three similar types of samples were realized by the optimized SPME-GC-MS method. With the obtained GC-MS data, a valid and well-fit model was established by partial least square discriminant analysis (PLS-DA) for classification of these samples (R2X=0.661, R2Y=0.996, Q2=0.986). The validity of the model (R2=0.266, Q2=-0.465) has also approved the potential to predict the "belongingness" of new samples. With the PLS-DA and SPSS method, further screening out the markers among three similar batches of samples may be helpful for monitoring and controlling the quality of the flavoring mixtures as additives in food industry. Conversely, the reliability and effectiveness of the GC-MS data has verified the comprehensive and efficient extraction performance of the in-house fabricated fiber. Copyright © 2016 Elsevier B.V. All rights reserved.

  11. Investigation on non-glass laser fusion targets: their fabrication, characterization, and transport. Charged Particle Research Laboratory report No. 2-81, progress report, June 1, 1980-January 31, 1981

    International Nuclear Information System (INIS)

    Kim, K.

    1981-01-01

    A summary is presented of the research progress made under LLNL Subcontract 8320003 for the period of June 1, 1980 through January 31, 1981. The main theme of the research has continued to be the development of techniques for fabricating, characterizing, and transporting laser fusion targets on a continuous basis. The target fabrication techniques are intended mainly for non-glass spherical shell targets, both cryogenic and non-cryogenic. Specifically, progress has been made in each of the following categories. (1) Investigation of liquid hydrogen behavior inside a spherical laser fusion target. (2) Development of automated target characterization scheme. (3) Study of cryogenic target fabrication scheme utilizing cold-gas-levitation and electric field positioning. (4) Development of a cryogenic target fabrication system based on target free-fall method. (5) Generation of hydrogen powder using electro-hydrodynamic spraying. (6) Study of target-charging techniques for application to contactless cryogenic target fabrication. (7) Development of hollow metal sphere production technique. A brief summary of the research progress made in each category is presented

  12. Selective Detection of Target Volatile Organic Compounds in Contaminated Humid Air Using a Sensor Array with Principal Component Analysis

    Science.gov (United States)

    Itoh, Toshio; Akamatsu, Takafumi; Tsuruta, Akihiro; Shin, Woosuck

    2017-01-01

    We investigated selective detection of the target volatile organic compounds (VOCs) nonanal, n-decane, and acetoin for lung cancer-related VOCs, and acetone and methyl i-butyl ketone for diabetes-related VOCs, in humid air with simulated VOC contamination (total concentration: 300 μg/m3). We used six “grain boundary-response type” sensors, including four commercially available sensors (TGS 2600, 2610, 2610, and 2620) and two Pt, Pd, and Au-loaded SnO2 sensors (Pt, Pd, Au/SnO2), and two “bulk-response type” sensors, including Zr-doped CeO2 (CeZr10), i.e., eight sensors in total. We then analyzed their sensor signals using principal component analysis (PCA). Although the six “grain boundary-response type” sensors were found to be insufficient for selective detection of the target gases in humid air, the addition of two “bulk-response type” sensors improved the selectivity, even with simulated VOC contamination. To further improve the discrimination, we selected appropriate sensors from the eight sensors based on the PCA results. The selectivity to each target gas was maintained and was not affected by contamination. PMID:28753948

  13. Some reliability targets affecting the necessary provisions for in-service inspection and monitoring of LMFBR engineering components

    International Nuclear Information System (INIS)

    Bolt, P.R.

    1980-01-01

    The possible consequences of failure of primary and secondary sodium circuit components are discussed with particular reference to post incident fault diagnosis, remedial procedures and outage durations. The core support structures and steam generator units are identified as particularly important components in terms of economic consequence of their failure. Important safety considerations may also apply. Levels of reliability for core support and steam generator integrity, necessary to meet economic and certain safety criteria, are discussed and quantitative data is given. Possible failure and deterioration mechanisms which could result in unacceptable reductions in reliability are then identified for the core support and steam generator units. Following a consideration of the reliability targets and possible causes of loss of reliability, an appraisal is made of the necessary extent of in-service data to be obtained on component behaviour and condition. In-service inspection and monitoring methods that could be used to obtain this data are described. Consideration is given to UK and overseas inspection experience on LMFBR and other nuclear plant. (author)

  14. Some reliability targets affecting the necessary provisions for in-service inspection and monitoring of LMFBR engineering components

    Energy Technology Data Exchange (ETDEWEB)

    Bolt, P R [Fast Reactor Engineering, Plant Engineering Department, CEGB, Barnwood, Gloucester (United Kingdom)

    1980-11-01

    The possible consequences of failure of primary and secondary sodium circuit components are discussed with particular reference to post incident fault diagnosis, remedial procedures and outage durations. The core support structures and steam generator units are identified as particularly important components in terms of economic consequence of their failure. Important safety considerations may also apply. Levels of reliability for core support and steam generator integrity, necessary to meet economic and certain safety criteria, are discussed and quantitative data is given. Possible failure and deterioration mechanisms which could result in unacceptable reductions in reliability are then identified for the core support and steam generator units. Following a consideration of the reliability targets and possible causes of loss of reliability, an appraisal is made of the necessary extent of in-service data to be obtained on component behaviour and condition. In-service inspection and monitoring methods that could be used to obtain this data are described. Consideration is given to UK and overseas inspection experience on LMFBR and other nuclear plant. (author)

  15. Fabrication and characterization of a metal-packaged regenerated fiber Bragg grating strain sensor for structural integrity monitoring of high-temperature components

    International Nuclear Information System (INIS)

    Tu, Yun; Tu, Shan-Tung

    2014-01-01

    Assessment of the structural integrity of components operating at high temperatures requires the development of novel sensors to measure strain. A metal-packaged regenerated fiber Bragg grating (RFBG) sensor is developed for measurement of strain using titanium–silver magnetron sputtering and nickel electroplating. The strain response of the sensor mounted onto a flat tensile specimen by spot welding is evaluated by uniaxial tensile tests at constant temperatures ranging from room temperature to 400 °C. Similar tests are performed on a bare RFBG sensor for comparison. The metal-packaged RFBG strain sensor exhibits higher strain sensitivity than that of the bare RFBG sensor, as well as good linearity, stability and repeatability of strain measurements. A three-dimensional finite element model of the sensor is established to predict the strain sensitivity based on the sensing principle of the fiber Bragg grating. Comparisons of the experimental results with the numerical predictions for the strain sensitivity show a satisfactory agreement. These results demonstrate that the metal-packaged RFBG strain sensors can be successfully fabricated by combining magnetron sputtering with electroplating, and provide great promise for structural integrity monitoring of high-temperature components. (paper)

  16. Investigation of the impact of fabrication methods on the microstructure features of W-components of a He-cooled divertor

    International Nuclear Information System (INIS)

    Krauss, W.; Holstein, N.; Konys, J.; Mazul, I.

    2006-01-01

    Within the EU framework of the power plant conceptual study (PPCS), a He-cooled modular divertor concept to remove the expected heat loads of up to 15 MW/m 2 is investigated at Forschungszentrum Karlsruhe. These high loads require sufficient cooling of the divertor components, which can only be obtained by an adapted design together with a close interaction with materials issues and development of manufacturing processes. Physical aspects favor tungsten as a functional and structural material. The design work performed indicates that sufficient heat removal by He requires microstructured W-surfaces in the shape of pin or slot arrays, or else a multi-jet cooling technology. In this work, manufacturing processes (e.g. EDM, laser etching, PIM, ECM) were analyzed for their applicability and cost effectiveness for shaping of microstructured W-arrays. In a second step, their impact on the microstructure and, thus, on stability and function of the parts were investigated. First test arrays were fabricated by EDM and brazed into the designed finger-like cooling structures. However, testing showed clearly that further development of the structuring processes (e.g. PIM, ECM) for W-components and of improved W-alloys are necessary

  17. Fabrication of targets for transmutation of americium : synthesis of inertial matrix by sol-gel method. Procedure study on the infiltration of a radioactive solutions

    International Nuclear Information System (INIS)

    Fernandez Carretero, A.

    2002-01-01

    Transmutation and incineration are innovative options in the management and disposal of fission products and actinides. nevertheless, the fabrication of targets for transmutation and incineration of actinides and fission products require a reconsideration of conventional processes (mechanical blending) and the development of new procedures compatible with the high activity of these materials. This work presents th R and D of a new fabrication method called INRAM (Infiltration of Radioactive Materials) based on the infiltration of an actinide solution in a porous non radiotoxic material in the form of a pellet (up to 12% An), or beads (up to 40% An) produced by sol-gel. The first method have been used for the fabrication of spinel (MgAl 2 O 4 ) targets containing 11% Am, which have been irradiated in HFR-Petten (358.4 full power days). Post-test burn-up calculations showed that at the end of the irradiation the initial Am-241 concentration was reduced to 4%. The fraction of the initial americum atoms that have been fissioned is 28%. The main advantage of the INRAM method is that matrices with low or zero activity can be fabricated and formed into the required shape in an unshielded facility. This method offers other advantages over conventional ones, such as the active wastes are reduced, is easy to automate, adoptable to telemanipulation and dust free, which facilitate operator intervention and minimise radiation exposure to the personal. In addition, the infiltrant needs only be present in liquid form, i. e. it could be transferred directly from the reprocessing plant for fabrication into targets without conversion into-solid form. In order to optimise the infiltration process in depth investigations of all important process parameters, e. g. infiltration kinetics and metal (pu, Am) concentration in the feed solution, and also on extensive study or powder metallurgy parameters for the preparation of high quality fuel pellets with a high density, have been made. In

  18. Synthesis of ITO Powder by Dry Process and Lifetime Characteristics of the ITO Target Fabricated with its Powder

    Science.gov (United States)

    Takahashi, Seiichiro; Itoh, Hironori; Komatsu, Ryuichi

    Lifetime of an indium tin oxide (ITO) target is an important characteristic in the production of liquid crystal displays (LCDs). Increasing the sintering density of the ITO target is assumed to lead to an increased lifetime. So far, it has been clarified that the carbon concentration in In2O3 powder, the raw material of ITO targets, influences remarkably the target lifetime. In this study, with the aim of reducing the concentration of carbon in In2O3 powder, the synthesis of In2O3 powder containing dissolved Sn by a dry process was performed.

  19. Molecular crosstalk between cancer cells and tumor microenvironment components suggests potential targets for new therapeutic approaches in mobile tongue cancer

    International Nuclear Information System (INIS)

    Dayan, Dan; Salo, Tuula; Salo, Sirpa; Nyberg, Pia; Nurmenniemi, Sini; Costea, Daniela Elena; Vered, Marilena

    2012-01-01

    We characterized tumor microenvironment (TME) components of mobile tongue (MT) cancer patients in terms of overall inflammatory infiltrate, focusing on the protumorigenic/anti-inflammatory phenotypes and on cancer-associated fibroblasts (CAFs) in order to determine their interrelations and associations with clinical outcomes. In addition, by culturing tongue carcinoma cells (HSC-3) on a three-dimensional myoma organotypic model that mimics TME, we attempted to investigate the possible existence of a molecular crosstalk between cancer cells and TME components. Analysis of 64 cases of MT cancer patients revealed that the overall density of the inflammatory infiltrate was inversely correlated to the density of CAFs (P = 0.01), but that the cumulative density of the protumorigenic/anti-inflammatory phenotypes, including regulatory T cells (Tregs, Foxp3+), tumor-associated macrophages (TAM2, CD163+), and potentially Tregs-inducing immune cells (CD80+), was directly correlated with the density of CAFs (P = 0.01). The hazard ratio (HR) for recurrence in a TME rich in CD163+ Foxp3+ CD80+ was 2.9 (95% CI 1.03–8.6, P = 0.043 compared with low in CD163+ Foxp3+ CD80+). The HR for recurrence in a TME rich in CAFs was 4.1 (95% confidence interval [CI] 1.3–12.8, P = 0.012 compared with low in CAFs). In vitro studies showed cancer-derived exosomes, epithelial–mesenchymal transition process, fibroblast-to-CAF-like cell transdifferentiation, and reciprocal interrelations between different cytokines suggesting the presence of molecular crosstalk between cancer cells and TME components. Collectively, these results highlighted the emerging need of new therapies targeting this crosstalk between the cancer cells and TME components in MT cancer

  20. Targeting physical activity and nutrition interventions towards mothers with young children: a review on components that contribute to attendance and effectiveness

    NARCIS (Netherlands)

    Hartman, Marieke A.; Hosper, Karen; Stronks, Karien

    2011-01-01

    To gain insight into intervention components targeted specifically to mothers of young children that may contribute to attendance and effectiveness on physical activity and healthy eating. Systematic literature searches were performed using MEDLINE, Embase and cited references. Articles were

  1. Laser fabrication of beryllium components

    International Nuclear Information System (INIS)

    Hanafee, J.E.; Ramos, T.J.

    1995-08-01

    Working with the beryllium industry on commercial applications and using prototype parts, the authors have found that the use of lasers provides a high-speed, low-cost method of cutting beryllium metal, beryllium alloys, and beryllium-beryllium oxide composites. In addition, they have developed laser welding processes for commercial structural grades of beryllium that do not need a filler metal; i.e., autogenous welds were made in commercial structural grades of beryllium by using lasers

  2. Sodium modulates opioid receptors through a membrane component different from G-proteins. Demonstration by target size analysis

    International Nuclear Information System (INIS)

    Ott, S.; Costa, T.; Herz, A.

    1988-01-01

    The target size for opioid receptor binding was studied after manipulations known to affect the interactions between receptor and GTP-binding regulatory proteins (G-proteins). Addition of GTP or its analogs to the binding reaction, exposure of intact cells to pertussis toxin prior to irradiation, or treatment of irradiated membranes with N-ethylmaleimide did not change the target size (approximately equal to 100 kDa) for opioid receptors in NG 108-15 cells and rat brain. These data suggest that the 100-kDa species does not include an active subunit of a G-protein or alternatively that GTP does not promote the dissociation of the receptor-G-protein complex. The presence of Na+ (100 mM) in the radioligand binding assay induced a biphasic decay curve for agonist binding and a flattening of the monoexponential decay curve for a partial agonist. In both cases the effect was explained by an irradiation-induced loss of the low affinity state of the opioid receptor produced by the addition of Na+. This suggests that an allosteric inhibitor that mediates the effect of sodium on the receptor is destroyed at low doses of irradiation, leaving receptors which are no longer regulated by sodium. The effect of Na+ on target size was slightly increased by the simultaneous addition of GTP but was not altered by pertussis toxin treatment. Thus, the sodium unit is distinct from G-proteins and may represent a new component of the opioid receptor complex. Assuming a simple bimolecular model of one Na+ unit/receptor, the size of this inhibitor can be measured as 168 kDa

  3. Indium oxide co-doped with tin and zinc: A simple route to highly conducting high density targets for TCO thin-film fabrication

    Science.gov (United States)

    Saadeddin, I.; Hilal, H. S.; Decourt, R.; Campet, G.; Pecquenard, B.

    2012-07-01

    Indium oxide co-doped with tin and zinc (ITZO) ceramics have been successfully prepared by direct sintering of the powders mixture at 1300 °C. This allowed us to easily fabricate large highly dense target suitable for sputtering transparent conducting oxide (TCO) films, without using any cold or hot pressing techniques. Hence, the optimized ITZO ceramic reaches a high relative bulk density (˜ 92% of In2O3 theoretical density) and higher than the well-known indium oxide doped with tin (ITO) prepared under similar conditions. All X-ray diagrams obtained for ITZO ceramics confirms a bixbyte structure typical for In2O3 only. This indicates a higher solubility limit of Sn and Zn when they are co-doped into In2O3 forming a solid-solution. A very low value of electrical resistivity is obtained for [In2O3:Sn0.10]:Zn0.10 (1.7 × 10-3 Ω cm, lower than ITO counterpart) which could be fabricated to high dense ceramic target suing pressure-less sintering.

  4. Final report on production of Pu-238 in commercial power reactors: target fabrication, postirradiation examination, and plutonium and neptunium recovery

    International Nuclear Information System (INIS)

    Pobereskin, M.; Langendorfer, W.; Lowry, L.; Farmelo, D.; Scotti, V.; Kruger, O.

    1975-01-01

    Considerable interest has been generated in more extensive applications of radioisotope thermoelectric generator (RTG) systems. This raises questions concerning the availability of 238 Pu to supply an expanding demand. The development of much of this demand will depend upon a considerable reduction in cost of 238 Pu. Two neptunia--zirconia--fuel target rods, containing four sections each of different NpO 2 concentrations, were irradiated in the Connecticut Yankee Reactor for approximately one year. Following irradiation both target rods were subjected to nondestructive examination. One rod was chosen for destructive testing and analysis. Post-irradiation chemical analyses included total Pu and Np, ppM 236 Pu/ 238 Pu, and Pu isotopic abundance. The results of these analyses and of electron microprobe analysis which provided the relative Pu concentration across the pellet diameters are tabulated. It was concluded that the feasibility of all operations involved in the production of 238 Pu by irradiation of 237 NpO 2 targets in commercial nuclear power reactors was demonstrated and that the demonstration should be extended to a pilot-scale leading to installation of a full production capacity. (U.S.)

  5. Predicting ground contact events for a continuum of gait types: An application of targeted machine learning using principal component analysis.

    Science.gov (United States)

    Osis, Sean T; Hettinga, Blayne A; Ferber, Reed

    2016-05-01

    An ongoing challenge in the application of gait analysis to clinical settings is the standardized detection of temporal events, with unobtrusive and cost-effective equipment, for a wide range of gait types. The purpose of the current study was to investigate a targeted machine learning approach for the prediction of timing for foot strike (or initial contact) and toe-off, using only kinematics for walking, forefoot running, and heel-toe running. Data were categorized by gait type and split into a training set (∼30%) and a validation set (∼70%). A principal component analysis was performed, and separate linear models were trained and validated for foot strike and toe-off, using ground reaction force data as a gold-standard for event timing. Results indicate the model predicted both foot strike and toe-off timing to within 20ms of the gold-standard for more than 95% of cases in walking and running gaits. The machine learning approach continues to provide robust timing predictions for clinical use, and may offer a flexible methodology to handle new events and gait types. Copyright © 2016 Elsevier B.V. All rights reserved.

  6. Optimizing the fabrication process and interplay of device components of polymer solar cells using a field-based multiscale solar-cell algorithm

    International Nuclear Information System (INIS)

    Donets, Sergii; Pershin, Anton; Baeurle, Stephan A.

    2015-01-01

    Both the device composition and fabrication process are well-known to crucially affect the power conversion efficiency of polymer solar cells. Major advances have recently been achieved through the development of novel device materials and inkjet printing technologies, which permit to improve their durability and performance considerably. In this work, we demonstrate the usefulness of a recently developed field-based multiscale solar-cell algorithm to investigate the influence of the material characteristics, like, e.g., electrode surfaces, polymer architectures, and impurities in the active layer, as well as post-production treatments, like, e.g., electric field alignment, on the photovoltaic performance of block-copolymer solar-cell devices. Our study reveals that a short exposition time of the polymer bulk heterojunction to the action of an external electric field can lead to a low photovoltaic performance due to an incomplete alignment process, leading to undulated or disrupted nanophases. With increasing exposition time, the nanophases align in direction to the electric field lines, resulting in an increase of the number of continuous percolation paths and, ultimately, in a reduction of the number of exciton and charge-carrier losses. Moreover, we conclude by modifying the interaction strengths between the electrode surfaces and active layer components that a too low or too high affinity of an electrode surface to one of the components can lead to defective contacts, causing a deterioration of the device performance. Finally, we infer from the study of block-copolymer nanoparticle systems that particle impurities can significantly affect the nanostructure of the polymer matrix and reduce the photovoltaic performance of the active layer. For a critical volume fraction and size of the nanoparticles, we observe a complete phase transformation of the polymer nanomorphology, leading to a drop of the internal quantum efficiency. For other particle-numbers and -sizes

  7. Minimalism in fabrication of self-organized nanogels holding both anti-cancer drug and targeting moiety.

    Science.gov (United States)

    Kim, Sungwon; Park, Kyong Mi; Ko, Jin Young; Kwon, Ick Chan; Cho, Hyeon Geun; Kang, Dongmin; Yu, In Tag; Kim, Kwangmeyung; Na, Kun

    2008-05-01

    Recent researches to develop nano-carrier systems in anti-cancer drug delivery have focused on more complicated design to improve therapeutic efficacy and to reduce side effects. Although such efforts have great impact to biomedical science and engineering, the complexity has been a huddle because of clinical and economic problems. In order to overcome the problems, a simplest strategy to fabricate nano-carriers to deliver doxorubicin (DOX) was proposed in the present study. Two significant subjects (i) formation of nanoparticles loading and releasing DOX and (ii) binding specificity of them to cells, were examined. Folic acid (FA) was directly coupled with pullulan (Pul) backbone by ester linkage (FA/Pul conjugate) and the degree of substitution (DS) was varied, which were confirmed by 1H NMR and UV spectrophotometry. Light scattering results revealed that the nanogels possessed two major size distributions around 70 and 270 nm in an aqueous solution. Their critical aggregation concentrations (CACs) were less than 10 microg/mL, which are lower than general critical micelle concentrations (CMCs) of low-molecular-weight surfactants. Transmission electron microscopy (TEM) images showed well-dispersed nanogel morphology in a dried state. Depending on the DS, the nanogels showed different DOX-loading and releasing profiles. The DOX release rate from FA8/Pul (with the highest DS) for 24h was slower than that from FA4/or FA6/Pul, indicating that the FA worked as a hydrophobic moiety for drug holding. Cellular uptake of the nanogels (KB cells) was also monitored by confocal microscopy. All nanogels were internalized regardless of the DS of FA. Based on the results, the objectives of this study, to suggest a new method overcoming the complications in the drug carrier design, were successfully verified.

  8. Remote Monitoring of a Multi-Component Liquid-Phase Organic Synthesis by Infrared Emission Spectroscopy: The Recovery of Pure Component Emissivities by Band-Target Entropy Minimization

    Czech Academy of Sciences Publication Activity Database

    Cheng, S.; Tjahjono, M.; Rajarathnam, D.; Chuanzhao, L.; Lyapkalo, Ilya; Chen, D.; Garland, M.

    2007-01-01

    Roč. 61, č. 10 (2007), s. 1057-1062 ISSN 0003-7028 Institutional research plan: CEZ:AV0Z40550506 Keywords : infrared emission spectroscopy * liquid phase reaction * band-target entropy minimization * BTEM * emittance Subject RIV: CC - Organic Chemistry Impact factor: 1.902, year: 2007

  9. Intrinsic ZnO films fabricated by DC sputtering from oxygen-deficient targets for Cu(In,Ga)Se2 solar cell application

    Institute of Scientific and Technical Information of China (English)

    Chongyin Yang; DongyunWan; Zhou Wang; Fuqiang Huang

    2011-01-01

    Intrinsic zinc oxide films, normally deposited by radio frequency (RF) sputtering, are fabricated by direct current (DC) sputtering. The oxygen-deficient targets are prepared via a newly developed double crucible method. The 800-nm-thick film obtaines significantly higher carrier mobility compareing with that of the 800-nm-thick ZnO film. This is achieved by the widely used RF sputtering, which favors the prevention of carrier recombination at the interfaces and reduction of the series resistance of solar cells. The optimal ZnO film is used in a Cu (In, Ga) Se2 (CIGS) solar cell with a high efficiency of 11.57%. This letter demonstrates that the insulating ZnO films can be deposited by DC sputtering from oxygen-deficient ZnO targets to lower the cost of thin film solar cells.%Intrinsic zinc oxide films,normally deposited by radio frequency (RF) sputtering,are fabricated by direct current (DC) sputtering.The oxygen-deficient targets are prepared via a newly developed double crucible method.The 800-nm-thick film obtaines significantly higher carrier mobility compareing with that of the 800-nm-thick ZnO film.This is achieved by the widely used RF sputtering,which favors the prevention of carrier recombination at the interfaces and reduction of the series resistance of solar cells.The optimal ZnO film is used in a Cu (In,Ga) Se2 (C1GS) solar cell with a high efficiency of 11.57%.This letter demonstrates that the insulating ZnO films can be deposited by DC sputtering from oxygen-deficient ZnO targets to lower the cost of thin film solar cells.High resistance transparent intrinsic zinc oxide (i-ZnO)thin film has been widely nsed as the front electrode in transparent electronics and photovoltaic devices because of its low cost and nontoxicity.Owing to its unique characteristics of high transparency and adjustable resistivity in a certain range,the use of i-ZnO thin films as diffusion barrier layers of a-Si/μc-Si,CdTe,and CIGS thin-film solar cells has been advantageous

  10. Fabrication of nano-mosquitocides using chitosan from crab shells: Impact on non-target organisms in the aquatic environment.

    Science.gov (United States)

    Murugan, Kadarkarai; Anitha, Jaganathan; Dinesh, Devakumar; Suresh, Udaiyan; Rajaganesh, Rajapandian; Chandramohan, Balamurugan; Subramaniam, Jayapal; Paulpandi, Manickam; Vadivalagan, Chitravel; Amuthavalli, Pandiyan; Wang, Lan; Hwang, Jiang-Shiou; Wei, Hui; Alsalhi, Mohamad Saleh; Devanesan, Sandhanasamy; Kumar, Suresh; Pugazhendy, Kannaiyan; Higuchi, Akon; Nicoletti, Marcello; Benelli, Giovanni

    2016-10-01

    Mosquitoes are arthropods of huge medical and veterinary relevance, since they vector pathogens and parasites of public health importance, including malaria, dengue and Zika virus. Currently, nanotechnology is considered a potential eco-friendly approach in mosquito control research. We proposed a novel method of biofabrication of silver nanoparticles (AgNP) using chitosan (Ch) from crab shells. Ch-AgNP nanocomposite was characterized by UV-vis spectroscopy, FTIR, SEM, EDX and XRD. Ch-AgNP were tested against larvae and pupae of the malaria vector Anopheles stephensi obtaining LC50 ranging from 3.18 ppm (I) to 6.54 ppm (pupae). The antibacterial properties of Ch-AgNP were proved against Bacillus subtilis, Klebsiella pneumoniae and Salmonella typhi, while no growth inhibition was reported in assays conducted on Proteus vulgaris. Concerning non-target effects, in standard laboratory considtions the predation efficiency of Danio rerio zebrafishes was 68.8% and 61.6% against I and II instar larvae of A. stephensi, respectively. In a Ch-AgNP-contaminated environment, fish predation was boosted to 89.5% and 77.3%, respectively. Quantitative analysis of antioxidant enzymes SOD, CAT and LPO from hepatopancreas of fresh water crabs Paratelphusa hydrodromous exposed for 16 days to a Ch-AgNP-contaminated aquatic environment were conducted. Notably, deleterious effects of Ch-AgNP contaminating aquatic enviroment on the non-target crab P. hydrodromous were observed, particularly when doses higher than 8-10ppm are tested. Overall, this research highlights the potential of Ch-AGNP for the development of newer control tools against young instar populations of malaria mosquitoes, also highlighting some risks concerned the employ of nanoparticles in aquatic environments. Copyright © 2016 Elsevier Inc. All rights reserved.

  11. Induction of biogenic magnetization and redox control by a component of the target of rapamycin complex 1 signaling pathway.

    Directory of Open Access Journals (Sweden)

    Keiji Nishida

    Full Text Available Most organisms are simply diamagnetic, while magnetotactic bacteria and migratory animals are among organisms that exploit magnetism. Biogenic magnetization not only is of fundamental interest, but also has industrial potential. However, the key factor(s that enable biogenic magnetization in coordination with other cellular functions and metabolism remain unknown. To address the requirements for induction and the application of synthetic bio-magnetism, we explored the creation of magnetism in a simple model organism. Cell magnetization was first observed by attraction towards a magnet when normally diamagnetic yeast Saccharomyces cerevisiae were grown with ferric citrate. The magnetization was further enhanced by genetic modification of iron homeostasis and introduction of ferritin. The acquired magnetizable properties enabled the cells to be attracted to a magnet, and be trapped by a magnetic column. Superconducting quantum interference device (SQUID magnetometry confirmed and quantitatively characterized the acquired paramagnetism. Electron microscopy and energy-dispersive X-ray spectroscopy showed electron-dense iron-containing aggregates within the magnetized cells. Magnetization-based screening of gene knockouts identified Tco89p, a component of TORC1 (Target of rapamycin complex 1, as important for magnetization; loss of TCO89 and treatment with rapamycin reduced magnetization in a TCO89-dependent manner. The TCO89 expression level positively correlated with magnetization, enabling inducible magnetization. Several carbon metabolism genes were also shown to affect magnetization. Redox mediators indicated that TCO89 alters the intracellular redox to an oxidized state in a dose-dependent manner. Taken together, we demonstrated that synthetic induction of magnetization is possible and that the key factors are local redox control through carbon metabolism and iron supply.

  12. Mechanical and tribological properties of polymer-derived Si/C/N sub-millimetre thick miniaturized components fabricated by direct casting

    OpenAIRE

    Bakumov Vadym; Blugan Gurdial; Roos Sigfried; Graule Thomas J.; Fakhfouri Vahid; Grossenbacher Jonas; Gullo Maurizio Rosario; Kiefer Thomas C.; Brugger Juergen; Parlinska Magdalena; Kuebler Jakob

    2012-01-01

    The utilization of silicon based polymers as a source of amorphous non oxide ceramics obtained upon pyrolytic treatment of them is increasingly gaining attention in research and is currently expanding into the field of commercial products. This work is focused on the near net shaped fabrication mechanical and tribological properties of a polymer derived Si/C/N system. Small sub millimetre thick ceramic test discs and bars were fabricated by casting of polysilazane and/or polycarbosilane precu...

  13. Functional Dissociation of Latency-Variable, Stimulus- and Response-Locked Target P3 Sub-components in Task-Switching.

    Science.gov (United States)

    Brydges, Christopher R; Barceló, Francisco

    2018-01-01

    Cognitive control warrants efficient task performance in dynamic and changing environments through adjustments in executive attention, stimulus and response selection. The well-known P300 component of the human event-related potential (ERP) has long been proposed to index "context-updating"-critical for cognitive control-in simple target detection tasks. However, task switching ERP studies have revealed both target P3 (300-350 ms) and later sustained P3-like potentials (400-1,200 ms) to first targets ensuing transition cues, although it remains unclear whether these target P3-like potentials also reflect context updating operations. To address this question, we applied novel single-trial EEG analyses-residue iteration decomposition (RIDE)-in order to disentangle target P3 sub-components in a sample of 22 young adults while they either repeated or switched (updated) task rules. The rationale was to revise the context updating hypothesis of P300 elicitation in the light of new evidence suggesting that "the context" consists of not only the sensory units of stimulation, but also associated motor units, and intermediate low- and high-order sensorimotor units, all of which may need to be dynamically updated on a trial by trial basis. The results showed functionally distinct target P3-like potentials in stimulus-locked, response-locked, and intermediate RIDE component clusters overlying parietal and frontal regions, implying multiple functionally distinct, though temporarily overlapping context updating operations. These findings support a reformulated version of the context updating hypothesis, and reveal a rich family of distinct target P3-like sub-components during the reactive control of target detection in task-switching, plausibly indexing the complex and dynamic workings of frontoparietal cortical networks subserving cognitive control.

  14. Effect of dopants and thermal treatment on properties of Ga-Al-ZnO thin films fabricated by hetero targets sputtering system

    International Nuclear Information System (INIS)

    Hong, JeongSoo; Matsushita, Nobuhiro; Kim, KyungHwan

    2013-01-01

    In this study, we fabricated Ga and Al doped ZnO (Ga-Al-ZnO; GAZO) thin films by using the facing targets sputtering system under various conditions such as input current and thermal treatment temperature. The properties of the as-deposited GAZO thin films were examined by four-point, UV/Vis spectrometry, X-ray diffraction, atomic force microscopy and field-emission scanning electron microscopy. The result showed that the lowest sheet resistance of the films was 59.3 ohm/sq and transmittance was about 85%. After thermal treatment, the properties of GAZO thin films were improved. The lowest sheet resistance (47.3 ohm/sq) of the GAZO thin films were obtained at thermal treatment temperature of 300 °C, considered to be the result of continuous substitutions by dopants and improved crystallinity by the thermal treatment. - Highlights: ► Ga and Al doped ZnO thin films were prepared by hetero targets sputtering system. ► Free electrons were increased due to the continuous substitutions of Ga and Al. ► Crystallinity was improved by recombination of particles with increasing of temperature

  15. Fabrication and application of a magnetic-targeting and controlled-release system using ST68-based microbubbles

    International Nuclear Information System (INIS)

    Xing Zhanwen; Ke Hengte; Wang Jinrui; Zhao Bo; Qu Enze; Yue Xiuli; Dai Zhifei

    2013-01-01

    Objective: To manufacture magnetic microbubbles with dual-response to ultrasound and magnetic fields. Methods: Microbubbles of ultrasound contrast agent (ST68) based on a surfactant were prepared by the acoustic cavitation method. Fe 3 O 4 magnetic nanoparticles with negative charge were synthesized using the polyol procedure. Magnetic microbubbles were generated by depositing polyethylenimine and Fe 3 O 4 magnetic nanoparticles alternately onto the microbubbles using the layer-by-layer self-assembly. In vitro ultrasonography was performed on a silicone tube with/without magnetic microbubbles (3 × 10 8 /ml) by a self-made device to observe the movement of magnetic microbubbles under the effects of magnetic field. In vivo imaging was performed on the kidney of New Zealand rabbits before and after the injection of magnetic microbubbles. Results: The Fe 3 O 4 nanoparticles carried a stable negative charge of (-24.6 ± 6.7) mV and more than 98% of the particles were less than 8 μm in diameter, meeting the size requirement of an ultrasound contrast agent for intravenous administration. There was no echoic signal in the silicone tube before injection of magnetic microbubbles, but there were strong echoic signals after injection. After applying a magnetic field, the magnetic microbubbles moved along the direction of the magnetic flux. In vivo ultrasound imaging could not visualize the kidney before injection of magnetic microbubbles, but could remarkably visualize the kidney after injection. Conclusions: The magnetic microbubbles exhibit favorable magnetic targeting and ultrasound contrast enhancement characteristics. Such properties may serve as the foundation to study their potential for simultaneous diagnosis and treatment in the future. (authors)

  16. Dual-target screening of bioactive components from traditional Chinese medicines by hollow fiber-based ligand fishing combined with liquid chromatography-mass spectrometry.

    Science.gov (United States)

    Chen, Liang; Wang, Xin; Liu, Youping; Di, Xin

    2017-09-05

    A novel strategy was developed for dual-target screening of bioactive components from traditional Chinese medicines (TCMs). This strategy was based on the use of low-cost microporous hollow fibers filled with target enzymes as baits to "fish out" the ligands in TCM extracts, followed by identification of the ligands dissociated from the target-ligand complexes by liquid chromatography-mass spectrometry. Ganjiang Huangqin Huanglian Renshen Decoction (GHHRD), a classical TCM prescription for diabetes treatment, was chosen as a model sample to evaluate the feasibility of the proposed strategy. Three bioactive components were successfully screened out from GHHRD. Coptisine was identified as the ligand of α-glucosidase and baicalin as the ligand of angiotensin-converting enzyme (ACE). Berberine was found to be a dual inhibitor of α-glucosidase and ACE. The results were further verified by enzyme inhibitory assay and molecular docking simulation. The study suggested that our developed strategy would be a powerful tool for screening bioactive components from multi-component and multi-target TCMs. Copyright © 2017 Elsevier B.V. All rights reserved.

  17. Construction, fabrication, and installation

    International Nuclear Information System (INIS)

    1992-05-01

    This standard specifies the construction, fabrication, and installation requirements that apply to concrete containment structures of a containment system designated as class containment components, parts and appurtenances for nuclear power plants

  18. Measurement of the Neutron Component in a Shower Generated in a Lead Target by Relativistic Nuclear Beam

    International Nuclear Information System (INIS)

    Chultehm, D.; Damdinsurehn, Ts.; D'yachenko, V.M.; Ehnkhzhin, L.; Lomova, L.A.; Perelygin, V.P.; Tolstov, K.D.

    1994-01-01

    The present paper describes a method of determining the total number of neutrons generated in an extended lead target by relativistic nuclei and protons. It is shown that 101±20 neutrons per proton are produced in the target with the volume of 50x50x80 cm 3 at 3.65 GeV energy of protons. 11 refs., 14 figs., 1 tab

  19. Detecting 3-D rotational motion and extracting target information from the principal component analysis of scatterer range histories

    CSIR Research Space (South Africa)

    Nel, W

    2009-10-01

    Full Text Available to estimate the 3-D position of scatterers as a by-product of the analysis. The technique is based on principal component analysis of accurate scatterer range histories and is shown only in simulation. Future research should focus on practical application....

  20. Fabricated Elastin.

    Science.gov (United States)

    Yeo, Giselle C; Aghaei-Ghareh-Bolagh, Behnaz; Brackenreg, Edwin P; Hiob, Matti A; Lee, Pearl; Weiss, Anthony S

    2015-11-18

    The mechanical stability, elasticity, inherent bioactivity, and self-assembly properties of elastin make it a highly attractive candidate for the fabrication of versatile biomaterials. The ability to engineer specific peptide sequences derived from elastin allows the precise control of these physicochemical and organizational characteristics, and further broadens the diversity of elastin-based applications. Elastin and elastin-like peptides can also be modified or blended with other natural or synthetic moieties, including peptides, proteins, polysaccharides, and polymers, to augment existing capabilities or confer additional architectural and biofunctional features to compositionally pure materials. Elastin and elastin-based composites have been subjected to diverse fabrication processes, including heating, electrospinning, wet spinning, solvent casting, freeze-drying, and cross-linking, for the manufacture of particles, fibers, gels, tubes, sheets and films. The resulting materials can be tailored to possess specific strength, elasticity, morphology, topography, porosity, wettability, surface charge, and bioactivity. This extraordinary tunability of elastin-based constructs enables their use in a range of biomedical and tissue engineering applications such as targeted drug delivery, cell encapsulation, vascular repair, nerve regeneration, wound healing, and dermal, cartilage, bone, and dental replacement. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. Structural impact of armor monoblock dimensions on the failure behavior of ITER-type divertor target components: Size matters

    Energy Technology Data Exchange (ETDEWEB)

    Li, Muyuan; You, Jeong-Ha, E-mail: you@ipp.mpg.de

    2016-12-15

    Highlights: • Quantitative assessment of size effects was conducted numerically for W monoblock. • Decreasing the width of W monoblock leads to a lower risk of failure. • The Cu interlayer was not affected significantly by varying armor thickness. • The predicted trends were in line with the experimental observations. - Abstract: Plenty of high-heat-flux tests conducted on tungsten monoblock type divertor target mock-ups showed that the threshold heat flux density for cracking and fracture of tungsten armor seems to be related to the dimension of the monoblocks. Thus, quantitative assessment of such size effects is of practical importance for divertor target design. In this paper, a computational study about the thermal and structural impact of monoblock size on the plastic fatigue and fracture behavior of an ITER-type tungsten divertor target is reported. As dimensional parameters, the width and thickness of monoblock, the thickness of sacrificial armor, and the inner diameter of cooling tube were varied. Plastic fatigue lifetime was estimated for the loading surface of tungsten armor and the copper interlayer by use of a cyclic-plastic constitutive model. The driving force of brittle crack growth through the tungsten armor was assessed in terms of J-integral at the crack tip. Decrease of the monoblock width effectively reduced accumulation of plastic strain at the armor surface and the driving force of brittle cracking. Decrease of sacrificial armor thickness led to decrease of plastic deformation at the loading surface due to lower surface temperature, but the thermal and mechanical response of the copper interlayer was not affected by the variation of armor thickness. Monoblock with a smaller tube diameter but with the same armor thickness and shoulder thickness experienced lower fatigue load. The predicted trends were in line with the experimental observations.

  2. Barriers and Facilitators for Teachers' Implementation of the Curricular Component of the Boost Intervention Targeting Adolescents' Fruit and Vegetable Intake

    DEFF Research Database (Denmark)

    Jørgensen, Thea Suldrup; Krølner, Rikke; Aarestrup, Anne Kristine

    2014-01-01

    OBJECTIVE: To examine barriers and facilitators to teachers' implementation of the curricular component of the school-based, multicomponent Boost intervention to promote fruit and vegetable intake among 13-year-olds guided by concepts of Diffusion of Innovations Theory and findings of previous...... and extra workload and motivated by a pre-intervention workshop and the thoroughness of the project. Detailed implementation manuals were helpful for some teachers but a barrier to others because they limited opportunities for adaptation. CONCLUSIONS AND IMPLICATIONS: Implementation of curricular activities...

  3. How insects overcome two-component plant chemical defence: plant β-glucosidases as the main target for herbivore adaptation.

    Science.gov (United States)

    Pentzold, Stefan; Zagrobelny, Mika; Rook, Fred; Bak, Søren

    2014-08-01

    Insect herbivory is often restricted by glucosylated plant chemical defence compounds that are activated by plant β-glucosidases to release toxic aglucones upon plant tissue damage. Such two-component plant defences are widespread in the plant kingdom and examples of these classes of compounds are alkaloid, benzoxazinoid, cyanogenic and iridoid glucosides as well as glucosinolates and salicinoids. Conversely, many insects have evolved a diversity of counteradaptations to overcome this type of constitutive chemical defence. Here we discuss that such counter-adaptations occur at different time points, before and during feeding as well as during digestion, and at several levels such as the insects’ feeding behaviour, physiology and metabolism. Insect adaptations frequently circumvent or counteract the activity of the plant β-glucosidases, bioactivating enzymes that are a key element in the plant’s two-component chemical defence. These adaptations include host plant choice, non-disruptive feeding guilds and various physiological adaptations as well as metabolic enzymatic strategies of the insect’s digestive system. Furthermore, insect adaptations often act in combination, may exist in both generalists and specialists, and can act on different classes of defence compounds. We discuss how generalist and specialist insects appear to differ in their ability to use these different types of adaptations: in generalists, adaptations are often inducible, whereas in specialists they are often constitutive. Future studies are suggested to investigate in detail how insect adaptations act in combination to overcome plant chemical defences and to allow ecologically relevant conclusions.

  4. Strength of PLA Components Fabricated with Fused Deposition Technology Using a Desktop 3D Printer as a Function of Geometrical Parameters of the Process

    Directory of Open Access Journals (Sweden)

    Vladimir E. Kuznetsov

    2018-03-01

    Full Text Available The current paper studies the influence of geometrical parameters of the fused deposition modeling (FDM—fused filament fabrication (FFF 3D printing process on printed part strength for open source desktop 3D printers and the most popular material used for that purpose—i.e., polylactic acid (PLA. The study was conducted using a set of different nozzles (0.4, 0.6, and 0.8 mm and a range of layer heights from the minimum to maximum physical limits of the machine. To assess print strength, a novel assessment method is proposed. A tubular sample is loaded in the weakest direction (across layers in a three-point bending fixture. Mesostructure evaluation through scanning electronic microscopy (SEM scans of the samples was used to explain the obtained results. We detected a significant influence of geometric process parameters on sample mesostructure, and consequently, on sample strength.

  5. Structure and Potential Cellular Targets of HAMLET-like Anti-Cancer Compounds made from Milk Components.

    Science.gov (United States)

    Rath, Emma M; Duff, Anthony P; Håkansson, Anders P; Vacher, Catherine S; Liu, Guo Jun; Knott, Robert B; Church, William Bret

    2015-01-01

    The HAMLET family of compounds (Human Alpha-lactalbumin Made Lethal to Tumours) was discovered during studies on the properties of human milk, and is a class of protein-lipid complexes having broad spectrum anti-cancer, and some specific anti-bacterial properties. The structure of HAMLET-like compounds consists of an aggregation of partially unfolded protein making up the majority of the compound's mass, with fatty acid molecules bound in the hydrophobic core. This is a novel protein-lipid structure and has only recently been derived by small-angle X-ray scattering analysis. The structure is the basis of a novel cytotoxicity mechanism responsible for anti-cancer activity to all of the around 50 different cancer cell types for which the HAMLET family has been trialled. Multiple cytotoxic mechanisms have been hypothesised for the HAMLET-like compounds, but it is not yet clear which of those are the initiating cytotoxic mechanism(s) and which are subsequent activities triggered by the initiating mechanism(s). In addition to the studies into the structure of these compounds, this review presents the state of knowledge of the anti-cancer aspects of HAMLET-like compounds, the HAMLET-induced cytotoxic activities to cancer and non-cancer cells, and the several prospective cell membrane and intracellular targets of the HAMLET family. The emerging picture is that HAMLET-like compounds initiate their cytotoxic effects on what may be a cancer-specific target in the cell membrane that has yet to be identified. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page.

  6. Pre-qualification of brazed plasma facing components of divertor target elements for ITER like tokamak application

    International Nuclear Information System (INIS)

    Singh, K.P.; Pandya, Santosh P.; Khirwadkar, S.S.; Patel, Alpesh; Patil, Y.; Buch, J.J.U.; Khan, M.S.; Tripathi, Sudhir; Pandya, Shwetang; Govindrajan, J.; Jaman, P.M.; Rathore, Devendra; Rangaraj, L.; Divakar, C.

    2011-01-01

    Qualification of tungsten (W) and graphite (C) based brazed plasma facing components (PFCs) is an important R and D area in fusion research. Pre-qualification tests for brazed joints between W-CuCrZr and C-CuCrZr using NDT (IR thermography and ultrasonic test) and thermal fatigue test are attempted. Mockups having good quality brazed joints of W and C based PFCs were identified using NDT. Subsequently, thermal fatigue test was performed on the identified mockups. All brazed tiles of W based PFC mockups could withstand thermal fatigue test, however, few tiles of C based PFC mockup were found detached. Thermal analyses of mockups are performed using finite element analysis (ANSYS) software to simulate the thermal hydraulic condition with 10 MW/m 2 uniform heat flux. Details about experimental and computational work are presented here.

  7. Pre-qualification of brazed plasma facing components of divertor target elements for ITER like tokamak application

    Energy Technology Data Exchange (ETDEWEB)

    Singh, K.P., E-mail: kpsingh@ipr.res.in [Institute for Plasma Research, Bhat, Gandhinagar, Gujarat (India); Pandya, Santosh P.; Khirwadkar, S.S.; Patel, Alpesh; Patil, Y.; Buch, J.J.U.; Khan, M.S.; Tripathi, Sudhir; Pandya, Shwetang; Govindrajan, J. [Institute for Plasma Research, Bhat, Gandhinagar, Gujarat (India); Jaman, P.M.; Rathore, Devendra; Rangaraj, L.; Divakar, C. [Materials Science Division, National Aerospace Laboratories, CSIR, Bangalore, Karnataka (India)

    2011-10-15

    Qualification of tungsten (W) and graphite (C) based brazed plasma facing components (PFCs) is an important R and D area in fusion research. Pre-qualification tests for brazed joints between W-CuCrZr and C-CuCrZr using NDT (IR thermography and ultrasonic test) and thermal fatigue test are attempted. Mockups having good quality brazed joints of W and C based PFCs were identified using NDT. Subsequently, thermal fatigue test was performed on the identified mockups. All brazed tiles of W based PFC mockups could withstand thermal fatigue test, however, few tiles of C based PFC mockup were found detached. Thermal analyses of mockups are performed using finite element analysis (ANSYS) software to simulate the thermal hydraulic condition with 10 MW/m{sup 2} uniform heat flux. Details about experimental and computational work are presented here.

  8. Fabrication Facilities

    Data.gov (United States)

    Federal Laboratory Consortium — The Fabrication Facilities are a direct result of years of testing support. Through years of experience, the three fabrication facilities (Fort Hood, Fort Lewis, and...

  9. Fabricating off-diagonal components of frequency-dependent linear and nonlinear polarizabilities of doped quantum dots by Gaussian white noise

    International Nuclear Information System (INIS)

    Saha, Surajit; Ganguly, Jayanta; Ghosh, Manas

    2015-01-01

    We make a rigorous exploration of the profiles of off-diagonal components of frequency-dependent linear (α xy , α yx ), first nonlinear (β xyy , β yxx ), and second nonlinear (γ xxyy , γ yyxx ) polarizabilities of quantum dots driven by Gaussian white noise. The quantum dot is doped with repulsive Gaussian impurity. Noise has been applied additively and multiplicatively to the system. An external oscillatory electric field has also been applied to the system. Gradual variations of external frequency, dopant location, and noise strength give rise to interesting features of polarizability components. The observations reveal intricate interplay between noise strength and dopant location which designs the polarizability profiles. Moreover, the mode of application of noise also modulates the polarizability components. Interestingly, in case of additive noise the noise strength has no role on polarizabilities whereas multiplicative noise invites greater delicacy in them. The said interplay provides a rather involved framework to attain stable, enhanced, and often maximized output of linear and nonlinear polarizabilities. - Highlights: • Linear and nonlinear polarizabilities of quantum dot are studied. • The polarizability components are off-diagonal and frequency-dependent. • Quantum dot is doped with a repulsive impurity. • Doped system is subject to Gaussian white noise. • Mode of noise application affects polarizabilities

  10. Generalized synthetic aperture radar automatic target recognition by convolutional neural network with joint use of two-dimensional principal component analysis and support vector machine

    Science.gov (United States)

    Zheng, Ce; Jiang, Xue; Liu, Xingzhao

    2017-10-01

    Convolutional neural network (CNN), as a vital part of the deep learning research field, has shown powerful potential for automatic target recognition (ATR) of synthetic aperture radar (SAR). However, the high complexity caused by the deep structure of CNN makes it difficult to generalize. An improved form of CNN with higher generalization capability and less probability of overfitting, which further improves the efficiency and robustness of the SAR ATR system, is proposed. The convolution layers of CNN are combined with a two-dimensional principal component analysis algorithm. Correspondingly, the kernel support vector machine is utilized as the classifier layer instead of the multilayer perceptron. The verification experiments are implemented using the moving and stationary target acquisition and recognition database, and the results validate the efficiency of the proposed method.

  11. Patient-specific targeting guides compared with traditional instrumentation for glenoid component placement in shoulder arthroplasty: a multi-surgeon study in 70 arthritic cadaver specimens.

    Science.gov (United States)

    Throckmorton, Thomas W; Gulotta, Lawrence V; Bonnarens, Frank O; Wright, Stephen A; Hartzell, Jeffrey L; Rozzi, William B; Hurst, Jason M; Frostick, Simon P; Sperling, John W

    2015-06-01

    The purpose of this study was to compare the accuracy of patient-specific guides for total shoulder arthroplasty (TSA) with traditional instrumentation in arthritic cadaver shoulders. We hypothesized that the patient-specific guides would place components more accurately than standard instrumentation. Seventy cadaver shoulders with radiographically confirmed arthritis were randomized in equal groups to 5 surgeons of varying experience levels who were not involved in development of the patient-specific guidance system. Specimens were then randomized to patient-specific guides based off of computed tomography scanning, standard instrumentation, and anatomic TSA or reverse TSA. Variances in version or inclination of more than 10° and more than 4 mm in starting point were considered indications of significant component malposition. TSA glenoid components placed with patient-specific guides averaged 5° of deviation from the intended position in version and 3° in inclination; those with standard instrumentation averaged 8° of deviation in version and 7° in inclination. These differences were significant for version (P = .04) and inclination (P = .01). Multivariate analysis of variance to compare the overall accuracy for the entire cohort (TSA and reverse TSA) revealed patient-specific guides to be significantly more accurate (P = .01) for the combined vectors of version and inclination. Patient-specific guides also had fewer instances of significant component malposition than standard instrumentation did. Patient-specific targeting guides were more accurate than traditional instrumentation and had fewer instances of component malposition for glenoid component placement in this multi-surgeon cadaver study of arthritic shoulders. Long-term clinical studies are needed to determine if these improvements produce improved functional outcomes. Copyright © 2015 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Elsevier Inc. All rights reserved.

  12. Immune Response to Recombinant Adenovirus in Humans: Capsid Components from Viral Input Are Targets for Vector-Specific Cytotoxic T Lymphocytes

    Science.gov (United States)

    Molinier-Frenkel, Valérie; Gahery-Segard, Hanne; Mehtali, Majid; Le Boulaire, Christophe; Ribault, Sébastien; Boulanger, Pierre; Tursz, Thomas; Guillet, Jean-Gérard; Farace, Françoise

    2000-01-01

    We previously demonstrated that a single injection of 109 PFU of recombinant adenovirus into patients induces strong vector-specific immune responses (H. Gahéry-Ségard, V. Molinier-Frenkel, C. Le Boulaire, P. Saulnier, P. Opolon, R. Lengagne, E. Gautier, A. Le Cesne, L. Zitvogel, A. Venet, C. Schatz, M. Courtney, T. Le Chevalier, T. Tursz, J.-G. Guillet, and F. Farace, J. Clin. Investig. 100:2218–2226, 1997). In the present study we analyzed the mechanism of vector recognition by cytotoxic T lymphocytes (CTL). CD8+ CTL lines were derived from two patients and maintained in long-term cultures. Target cell infections with E1-deleted and E1-plus E2-deleted adenoviruses, as well as transcription-blocking experiments with actinomycin D, revealed that host T-cell recognition did not require viral gene transcription. Target cells treated with brefeldin A were not lysed, indicating that viral input protein-derived peptides are associated with HLA class I molecules. Using recombinant capsid component-loaded targets, we observed that the three major proteins could be recognized. These results raise the question of the use of multideleted adenoviruses for gene therapy in the quest to diminish antivector CTL responses. PMID:10906225

  13. Use of principal component analysis in the evaluation of adherence to statin treatment: a method to determine a potential target population for public health intervention.

    Science.gov (United States)

    Latry, Philippe; Martin-Latry, Karin; Labat, Anne; Molimard, Mathieu; Peter, Claude

    2011-08-01

    The prevalence of statin use is high but adherence low. For public health intervention to be rational, subpopulations of nonadherent subjects must be defined. To categorise statin users with respect to patterns of reimbursement, this study was performed using the main French health reimbursement database for the Aquitaine region of south-western France. The cohort included subjects who submitted a reimbursement for at least one delivery of a statin (index) during the inclusion period (1st of September 2004-31st of December 2004). Indicators of adherence from reimbursement data were considered for principal component analysis. The 119,570 subjects included and analysed had a sex ratio of 1.1, mean (SD) age of 65.9 (11.9), and 13% were considered incident statin users. Principal component analysis found three dimensions that explained 67% of the variance. Using a K-means classification combined with a hierarchical ascendant classification, six groups were characterised. One group was considered nonadherent (10% of study population) and one group least adherent (1%). This novel application of principal component analysis identified groups that may be potential targets for intervention. The least adherent group appears to be one of the most appropriate because of both its relatively small size for case review with prescribing physicians and its very poor adherence. © 2010 The Authors Fundamental and Clinical Pharmacology © 2010 Société Française de Pharmacologie et de Thérapeutique.

  14. Design, fabrication and testing of an improved high heat flux element, experience feedback on steady state plasma facing components in Tore Supra

    International Nuclear Information System (INIS)

    Schlosser, J.; Chappuis, P.; Chatelier, M.; Durocher, A.; Guilheim, D.; Lipa, M.; Mitteau, R.; Tonon, G.; Tsitrone, E.

    1998-01-01

    Actively cooled plasma facing components (PFC) have been developed and used in Tore Supra since 1985. One of the main technological problem is due to the expansion mismatch between graphite armour and metallic heat sink material. A first technology used graphite tiles with or without a reinforcement and a compliant layer, brazed with titanium copper-silver (TiCuAg) alloy. The next technology used carbon fiber material (CFC) tiles with a 2 mm pure copper compliant layer, since the good mechanical strength of the CFC allowed the reinforcement layer to be suppressed. No destructive inspection during the manufacturing procedure was found to be essential to insure a good reliability of the elements. (orig.)

  15. Benefits of Hot Isostatic Pressure/Powdered Metal (HIP/PM) and Additive Manufacturing (AM) To Fabricate Advanced Energy System Components

    Energy Technology Data Exchange (ETDEWEB)

    Horton, Nancy [Energy Industries of Ohio, Cleveland, OH (United States); Sheppard, Roy [Energy Industries of Ohio, Cleveland, OH (United States)

    2016-12-31

    Advanced Energy systems require large, complex components produced from materials capable of withstanding severe operating environments (high temperature, pressure, corrosivity). Such parts can be difficult to source, as conventional material processing technologies must be tailored to ensure a safe and cost effective approach to large-scale manufacture of quality structural advanced alloy components that meet the performance specifications of AE systems. (HIP/PM) has shown advantages over other manufacturing methods when working with these materials. For example, using HIP’ing in lieu of casting means significant savings in raw material costs, which for expensive, high-nickel alloys can be considerable for large-scale production. Use of HIP/PM also eliminates the difficulties resulting from reactivity of these materials in the molten state and facilitates manufacture of the large size requirements of the AE industry, producing a part that is defect and porosity free, thus further reducing or eliminating time and expense of post processing machining and weld repair. New advances in Additive Manufacturing (AM) techniques make it possible to further expand the benefits of HIP/PM in producing AE system components to create an even more robust manufacturing approach. Traditional techniques of welding and forming sheet metal to produce the HIP canisters can be time consuming and costly, with limitations on the complexity of part which can be achieved. A key benefit of AM is the freedom of design that it offers, so use of AM could overcome such challenges, ultimately enabling redesign of complete energy systems. A critical step toward this goal is material characterization of the required advanced alloys, for use in AM. Using Haynes 282, a high nickel alloy of interest to the Fossil Energy community, particularly for Advanced-UltraSuperCritical (AUSC) operating environments, as well as the crosscutting interests of the aerospace, defense and medical markets, this

  16. Developing Fabrication Technologies to Provide On Demand Manufacturing for Exploration of the Moon and Mars

    Science.gov (United States)

    Hammond, Monica S.; Good, James E.; Gilley, Scott D.; Howard, Richard W.

    2006-01-01

    NASA's human exploration initiative poses great opportunity and risk for manned and robotic missions to the Moon, Mars, and beyond. Engineers and scientists at the Marshall Space Flight Center (MSFC) are developing technologies for in situ fabrication capabilities during lunar and Martian surface operations utilizing provisioned and locally refined materials. Current fabrication technologies must be advanced to support the special demands and applications of the space exploration initiative such as power, weight and volume constraints. In Situ Fabrication and Repair (ISFR) will advance state-of-the-art technologies in support of habitat structure development, tools, and mechanical part fabrication. The repair and replacement of space mission components, such as life support items or crew exercise equipment, fall within the ISFR scope. This paper will address current fabrication technologies relative to meeting ISFR targeted capabilities, near-term advancement goals, and systematic evaluation of various fabrication methods.

  17. Ahead of the game protocol: a multi-component, community sport-based program targeting prevention, promotion and early intervention for mental health among adolescent males.

    Science.gov (United States)

    Vella, Stewart A; Swann, Christian; Batterham, Marijka; Boydell, Katherine M; Eckermann, Simon; Fogarty, Andrea; Hurley, Diarmuid; Liddle, Sarah K; Lonsdale, Chris; Miller, Andrew; Noetel, Michael; Okely, Anthony D; Sanders, Taren; Telenta, Joanne; Deane, Frank P

    2018-03-21

    There is a recognised need for targeted community-wide mental health strategies and interventions aimed specifically at prevention and early intervention in promoting mental health. Young males are a high need group who hold particularly negative attitudes towards mental health services, and these views are detrimental for early intervention and help-seeking. Organised sports provide a promising context to deliver community-wide mental health strategies and interventions to adolescent males. The aim of the Ahead of the Game program is to test the effectiveness of a multi-component, community-sport based program targeting prevention, promotion and early intervention for mental health among adolescent males. The Ahead of the Game program will be implemented within a sample drawn from community sporting clubs and evaluated using a sample drawn from a matched control community. Four programs are proposed, including two targeting adolescents, one for parents, and one for sports coaches. One adolescent program aims to increase mental health literacy, intentions to seek and/or provide help for mental health, and to decrease stigmatising attitudes. The second adolescent program aims to increase resilience. The goal of the parent program is to increase parental mental health literacy and confidence to provide help. The coach program is intended to increase coaches' supportive behaviours (e.g., autonomy supportive behaviours), and in turn facilitate high-quality motivation and wellbeing among adolescents. Programs will be complemented by a messaging campaign aimed at adolescents to enhance mental health literacy. The effects of the program on adolescent males' psychological distress and wellbeing will also be explored. Organised sports represent a potentially engaging avenue to promote mental health and prevent the onset of mental health problems among adolescent males. The community-based design, with samples drawn from an intervention and a matched control community

  18. Lab-on-chip components for molecular detection

    Science.gov (United States)

    Adam, Tijjani; Dhahi, Th S.; Mohammed, Mohammed; Hashim, U.; Noriman, N. Z.; Dahham, Omar S.

    2017-09-01

    We successfully fabricated Lab on chip components and integrated for possible use in biomedical application. The sensor was fabricated by using conventional photolithography method integrated with PDMS micro channels for smooth delivery of sample to the sensing domain. The sensor was silanized and aminated with 3-Aminopropyl triethoxysilane (APTES) to functionalize the surface with biomolecules and create molecular binding chemistry. The resulting Si-O-Si- components were functionalized with oligonucleotides probe of HPV, which interacted with the single stranded HPV DNA target to create a field across on the device. The fabrication, immobilization and hybridization processes were characterized with current voltage (I-V) characterization (KEITHLEY, 6487). The sensor show selectivity for the HPV DNA target in a linear range from concentration 0.1 nM to 1 µM. This strategy presented a simple, rapid and sensitive platform for HPV detection and would become a powerful tool for pathogenic microorganisms screening in clinical diagnosis.

  19. Toxicity of noradrenaline, a novel anti-biofouling component, to two non-target zooplankton species, Daphnia magna and Ceriodaphnia dubia.

    Science.gov (United States)

    Overturf, C L; Wormington, A M; Blythe, K N; Gohad, N V; Mount, A S; Roberts, A P

    2015-05-01

    Noradrenaline (NA) is the active component of novel antifouling agents and acts by preventing attachment of fouling organisms. The goal of this study was to examine the toxicity of NA to the non-target zooplankton D. magna and C. dubia. Neonates were exposed to one of five concentrations of NA and effects on survival, reproduction and molting were determined. Calculated LC50 values were determined to be 46 and 38 μM in C. dubia and D. magna, respectively. A 10-day C. dubia study found that reproduction metrics were significantly impacted at non-lethal concentrations. In D. magna, concentrations greater than 40 μM significantly impacted molting. A toxicity test was conducted with D. magna using oxidized NA, which yielded similar results. These data indicate that both NA and oxidized NA are toxic to non-target zooplankton. Results obtained from this study can be used to guide future ecological risk assessments of catecholamine-based antifouling agents. Copyright © 2015. Published by Elsevier Inc.

  20. Study the target effect on the structural, surface and optical properties of TiO2 thin film fabricated by RF sputtering method

    Science.gov (United States)

    Vyas, Sumit; Tiwary, Rohit; Shubham, Kumar; Chakrabarti, P.

    2015-04-01

    The effect of target (Ti metal target and TiO2 target) on Titanium Dioxide (TiO2) thin films grown on ITO coated glass substrate by RF magnetron sputtering has been investigated. A comparative study of both the films was done in respect of crystalline structure, surface morphology and optical properties by using X-ray diffractometer (XRD), Atomic Force Microscopy (AFM) studies and ellipsometric measurements. The XRD results confirmed the crystalline structure and indicated that the deposited films have the intensities of anatase phase. The surface morphology and roughness values indicated that the film using Ti metal target has a smoother surface and densely packed with grains as compared to films obtained using TiO2 target. A high transmission in the visible region, and direct band gap of 3.67 eV and 3.75 eV for films derived by using Ti metal and TiO2 target respectively and indirect bandgap of 3.39 eV for the films derived from both the targets (Ti metal and TiO2 target) were observed by the ellipsometric measurements.

  1. 10-Hydroxy-2-decenoic Acid, the Major Lipid Component of Royal Jelly, Extends the Lifespan of Caenorhabditis elegans through Dietary Restriction and Target of Rapamycin Signaling

    Directory of Open Access Journals (Sweden)

    Yoko Honda

    2015-01-01

    Full Text Available Royal jelly (RJ produced by honeybees has been reported to possess diverse health-beneficial properties and has been implicated to have a function in longevity across diverse species as well as honeybees. 10-Hydroxy-2-decenoic acid (10-HDA, the major lipid component of RJ produced by honeybees, was previously shown to increase the lifespan of Caenorhabditis elegans. The objective of this study is to elucidate signaling pathways that are involved in the lifespan extension by 10-HDA. 10-HDA further extended the lifespan of the daf-2 mutants, which exhibit long lifespan through reducing insulin-like signaling (ILS, indicating that 10-HDA extended lifespan independently of ILS. On the other hand, 10-HDA did not extend the lifespan of the eat-2 mutants, which show long lifespan through dietary restriction caused by a food-intake defect. This finding indicates that 10-HDA extends lifespan through dietary restriction signaling. We further found that 10-HDA did not extend the lifespan of the long-lived mutants in daf-15, which encodes Raptor, a target of rapamycin (TOR components, indicating that 10-HDA shared some longevity control mechanisms with TOR signaling. Additionally, 10-HDA was found to confer tolerance against thermal and oxidative stress. 10-HDA increases longevity not through ILS but through dietary restriction and TOR signaling in C. elegans.

  2. Overview of online two-dimensional liquid chromatography based on cell membrane chromatography for screening target components from traditional Chinese medicines.

    Science.gov (United States)

    Muhammad, Saqib; Han, Shengli; Xie, Xiaoyu; Wang, Sicen; Aziz, Muhammad Majid

    2017-01-01

    Cell membrane chromatography is a simple, specific, and time-saving technique for studying drug-receptor interactions, screening of active components from complex mixtures, and quality control of traditional Chinese medicines. However, the short column life, low sensitivity, low column efficiency (so cannot resolve satisfactorily mixture of compounds), low peak capacity, and inefficient in structure identification were bottleneck in its application. Combinations of cell membrane chromatography with multidimensional chromatography such as two-dimensional liquid chromatography and high sensitivity detectors like mass have significantly reduced many of the above-mentioned shortcomings. This paper provides an overview of the current advances in online two-dimensional-based cell membrane chromatography for screening target components from traditional Chinese medicines with particular emphasis on the instrumentation, preparation of cell membrane stationary phase, advantages, and disadvantages compared to alternative approaches. The last section of the review summarizes the applications of the online two-dimensional high-performance liquid chromatography based cell membrane chromatography reported since its emergence to date (2010-June 2016). © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  3. 10-Hydroxy-2-decenoic Acid, the Major Lipid Component of Royal Jelly, Extends the Lifespan of Caenorhabditis elegans through Dietary Restriction and Target of Rapamycin Signaling.

    Science.gov (United States)

    Honda, Yoko; Araki, Yoko; Hata, Taketoshi; Ichihara, Kenji; Ito, Masafumi; Tanaka, Masashi; Honda, Shuji

    2015-01-01

    Royal jelly (RJ) produced by honeybees has been reported to possess diverse health-beneficial properties and has been implicated to have a function in longevity across diverse species as well as honeybees. 10-Hydroxy-2-decenoic acid (10-HDA), the major lipid component of RJ produced by honeybees, was previously shown to increase the lifespan of Caenorhabditis elegans. The objective of this study is to elucidate signaling pathways that are involved in the lifespan extension by 10-HDA. 10-HDA further extended the lifespan of the daf-2 mutants, which exhibit long lifespan through reducing insulin-like signaling (ILS), indicating that 10-HDA extended lifespan independently of ILS. On the other hand, 10-HDA did not extend the lifespan of the eat-2 mutants, which show long lifespan through dietary restriction caused by a food-intake defect. This finding indicates that 10-HDA extends lifespan through dietary restriction signaling. We further found that 10-HDA did not extend the lifespan of the long-lived mutants in daf-15, which encodes Raptor, a target of rapamycin (TOR) components, indicating that 10-HDA shared some longevity control mechanisms with TOR signaling. Additionally, 10-HDA was found to confer tolerance against thermal and oxidative stress. 10-HDA increases longevity not through ILS but through dietary restriction and TOR signaling in C. elegans.

  4. Process for fabrication of cermets

    Science.gov (United States)

    Landingham, Richard L [Livermore, CA

    2011-02-01

    Cermet comprising ceramic and metal components and a molten metal infiltration method and process for fabrication thereof. The light weight cermets having improved porosity, strength, durability, toughness, elasticity fabricated from presintered ceramic powder infiltrated with a molten metal or metal alloy. Alumina titanium cermets biocompatible with the human body suitable for bone and joint replacements.

  5. Reforming Shapes for Material-aware Fabrication

    KAUST Repository

    Yang, Yongliang; Wang, Jun; Mitra, Niloy J.

    2015-01-01

    © 2015 The Eurographics Association and John Wiley & Sons Ltd. Published by John Wiley & Sons Ltd. As humans, we regularly associate shape of an object with its built material. In the context of geometric modeling, however, this inter-relation between form and material is rarely explored. In this work, we propose a novel data-driven reforming (i.e.; reshaping) algorithm that adapts an input multi-component model for a target fabrication material. The algorithm adapts both the part geometry and the inter-part topology of the input shape to better align with material-aware fabrication requirements. As output, we produce the reshaped model along with respective part dimensions and inter-part junction specifications. We evaluate our algorithm on a range of man-made models and demonstrate a variety of model reshaping examples focusing only on metal and wooden materials.

  6. Reforming Shapes for Material-aware Fabrication

    KAUST Repository

    Yang, Yongliang

    2015-08-10

    © 2015 The Eurographics Association and John Wiley & Sons Ltd. Published by John Wiley & Sons Ltd. As humans, we regularly associate shape of an object with its built material. In the context of geometric modeling, however, this inter-relation between form and material is rarely explored. In this work, we propose a novel data-driven reforming (i.e.; reshaping) algorithm that adapts an input multi-component model for a target fabrication material. The algorithm adapts both the part geometry and the inter-part topology of the input shape to better align with material-aware fabrication requirements. As output, we produce the reshaped model along with respective part dimensions and inter-part junction specifications. We evaluate our algorithm on a range of man-made models and demonstrate a variety of model reshaping examples focusing only on metal and wooden materials.

  7. Ginger components as new leads for the design and development of novel multi-targeted anti-Alzheimer’s drugs: a computational investigation

    Directory of Open Access Journals (Sweden)

    Azam F

    2014-10-01

    Full Text Available Faizul Azam,1,2 Abdualrahman M Amer,1 Abdullah R Abulifa,1 Mustafa M Elzwawi1 1Faculty of Pharmacy, Misurata University, Misurata, Libya; 2Department of Pharmaceutical Chemistry, Nims Institute of Pharmacy, Nims University, Jaipur, Rajasthan, India Abstract: Ginger (Zingiber officinale, despite being a common dietary adjunct that contributes to the taste and flavor of foods, is well known to contain a number of potentially bioactive phytochemicals having valuable medicinal properties. Although recent studies have emphasized their benefits in Alzheimer’s disease, limited information is available on the possible mechanism by which it renders anti-Alzheimer activity. Therefore, the present study seeks to employ molecular docking studies to investigate the binding interactions between active ginger components and various anti-Alzheimer drug targets. Lamarckian genetic algorithm methodology was employed for docking of 12 ligands with 13 different target proteins using AutoDock 4.2 program. Docking protocol was validated by re-docking of all native co-crystallized ligands into their original binding cavities exhibiting a strong correlation coefficient value (r2=0.931 between experimentally reported and docking predicted activities. This value suggests that the approach could be a promising computational tool to aid optimization of lead compounds obtained from ginger. Analysis of binding energy, predicted inhibition constant, and hydrophobic/hydrophilic interactions of ligands with target receptors revealed acetylcholinesterase as most promising, while c-Jun N-terminal kinase was recognized as the least favorable anti-Alzheimer’s drug target. Common structural requirements include hydrogen bond donor/acceptor area, hydrophobic domain, carbon spacer, and distal hydrophobic domain flanked by hydrogen bond donor/acceptor moieties. In addition, drug-likeness score and molecular properties responsible for a good pharmacokinetic profile were calculated

  8. Digital fabrication

    CERN Document Server

    2012-01-01

    The Winter 2012 (vol. 14 no. 3) issue of the Nexus Network Journal features seven original papers dedicated to the theme “Digital Fabrication”. Digital fabrication is changing architecture in fundamental ways in every phase, from concept to artifact. Projects growing out of research in digital fabrication are dependent on software that is entirely surface-oriented in its underlying mathematics. Decisions made during design, prototyping, fabrication and assembly rely on codes, scripts, parameters, operating systems and software, creating the need for teams with multidisciplinary expertise and different skills, from IT to architecture, design, material engineering, and mathematics, among others The papers grew out of a Lisbon symposium hosted by the ISCTE-Instituto Universitario de Lisboa entitled “Digital Fabrication – A State of the Art”. The issue is completed with four other research papers which address different mathematical instruments applied to architecture, including geometric tracing system...

  9. Nuclear Fabrication Consortium

    Energy Technology Data Exchange (ETDEWEB)

    Levesque, Stephen [EWI, Columbus, OH (United States)

    2013-04-05

    This report summarizes the activities undertaken by EWI while under contract from the Department of Energy (DOE) Office of Nuclear Energy (NE) for the management and operation of the Nuclear Fabrication Consortium (NFC). The NFC was established by EWI to independently develop, evaluate, and deploy fabrication approaches and data that support the re-establishment of the U.S. nuclear industry: ensuring that the supply chain will be competitive on a global stage, enabling more cost-effective and reliable nuclear power in a carbon constrained environment. The NFC provided a forum for member original equipment manufactures (OEM), fabricators, manufacturers, and materials suppliers to effectively engage with each other and rebuild the capacity of this supply chain by : Identifying and removing impediments to the implementation of new construction and fabrication techniques and approaches for nuclear equipment, including system components and nuclear plants. Providing and facilitating detailed scientific-based studies on new approaches and technologies that will have positive impacts on the cost of building of nuclear plants. Analyzing and disseminating information about future nuclear fabrication technologies and how they could impact the North American and the International Nuclear Marketplace. Facilitating dialog and initiate alignment among fabricators, owners, trade associations, and government agencies. Supporting industry in helping to create a larger qualified nuclear supplier network. Acting as an unbiased technology resource to evaluate, develop, and demonstrate new manufacturing technologies. Creating welder and inspector training programs to help enable the necessary workforce for the upcoming construction work. Serving as a focal point for technology, policy, and politically interested parties to share ideas and concepts associated with fabrication across the nuclear industry. The report the objectives and summaries of the Nuclear Fabrication Consortium

  10. A multi-component stair climbing promotional campaign targeting calorific expenditure for worksites; a quasi-experimental study testing effects on behaviour, attitude and intention

    Directory of Open Access Journals (Sweden)

    Eves Frank F

    2012-06-01

    Full Text Available Abstract Background Accumulation of lifestyle physical activity is a current aim of health promotion, with increased stair climbing one public health target. While the workplace provides an opportunity for regular stair climbing, evidence for effectiveness of point-of-choice interventions is equivocal. This paper reports a new approach to worksite interventions, aimed at changing attitudes and, hence, behaviour. Methods Pre-testing of calorific expenditure messages used structured interviews with members of the public (n = 300. Effects of multi-component campaigns on stair climbing were tested with quasi-experimental, interrupted time-series designs. In one worksite, a main campaign poster outlining the amount of calorific expenditure obtainable from stair climbing and a conventional point-of-choice prompt were used (Poster alone site. In a second worksite, additional messages in the stairwell about calorific expenditure reinforced the main campaign (Poster + Stairwell messages site. The outcome variables were automated observations of stair and lift ascent (28,854 and descent (29,352 at baseline and for three weeks after the intervention was installed. Post-intervention questionnaires for employees at the worksites assessed responses to the campaign (n = 253. Analyses employed Analysis of Variance with follow-up Bonferroni t-tests (message pre-testing, logistic regression of stair ascent and descent (campaign testing, and Bonferroni t-tests and multiple regression (follow-up questionnaire. Results Pre-testing of messages based on calorific expenditure suggested they could motivate stair climbing if believed. The new campaign increased stair climbing, with greater effects at the Poster + Stairwell messages site (OR = 1.52, 95% CI = 1.40-1.66 than Posters alone (OR = 1.24, 95% CI = 1.15-1.34. Follow-up revealed higher agreement with two statements about calorific outcomes of stair climbing in the site where they

  11. Fabrication and Characterisation of Optical Semiconductor Components

    DEFF Research Database (Denmark)

    Christiansen, Lotte Jin

    2006-01-01

    Formålet med projektet har været at fremstille en ny og simpel halvleder komponent til regenerering af optiske telekommunikations signaler. Mange af de hidtil mest brugte komponenter til dette formål er såkaldte interferometre, som kan være meget svære at fremstille rent procesteknisk, samtidig m...

  12. Laser-fusion target fabrication: application of organic coatings to metallic and nonmetallic micropellets by the glow-discharge polymerization of p-xylene

    International Nuclear Information System (INIS)

    Simonsic, G.A.

    1976-01-01

    Laser-fusion targets require thin, uniform organic-film coatings. A coating technique involving glow-discharge polymerization is described for applying highly adherent, extremely uniform, thin films of a high-temperature polymer to a variety of microsubstrates. Polymeric coatings as thick as 10 μm have been successfully deposited on hollow, spherical, 40- to 250-μm-diam micropellets of glass, metal-coated glass, and nickel/manganese alloy. Experimental yields of coatings of a quality acceptable for laser-fusion targets are typically greater than 90 percent

  13. miR-19, a component of the oncogenic miR-17∼92 cluster, targets the DNA-end resection factor CtIP

    DEFF Research Database (Denmark)

    Hühn, D; Kousholt, A N; Sørensen, Claus Storgaard

    2014-01-01

    MicroRNA-19 (miR-19) was recently identified as the key oncogenic component of the polycistronic miR-17∼92 cluster, also known as oncomiR-1, which is frequently upregulated or amplified in multiple tumor types. However, the gene targets and the pathways underlying the tumor-promoting activity of mi......R-19 still remain largely elusive. CtIP/RBBP8 promotes DNA-end resection, a critical step in the repair of DNA double-strand breaks (DSBs) by homologous recombination (HR), and is considered to function as a tumor suppressor. In this study, we show that miR-19 downregulates CtIP expression by binding...... to two highly conserved sequences located in the 3'-untranslated region of CtIP mRNA. We further demonstrate that CtIP expression is repressed by miR-19 during continuous genotoxic stress in a p53-dependent manner. Finally, we report that miR-19 impairs CtIP-mediated DNA-end resection, which results...

  14. Heavy-ion targets

    International Nuclear Information System (INIS)

    Adair, H.L.; Kobisk, E.H.

    1985-01-01

    This chapter examines the characteristics of targets required in heavy-ion accelerator physics experiments. The effects of target parameters on heavy-ion experimental results are reviewed. The target fabrication and characterization techniques used to minimize experimental problems during heavy-ion bombardment are described. Topics considered include target thickness and uniformity, target lifetime, target purity, substrate materials, Doppler shift effects, metal preparations, and target preparation methods

  15. Magnetic control system targeted for capsule endoscopic operations in the stomach--design, fabrication, and in vitro and ex vivo evaluations.

    Science.gov (United States)

    Lien, Gi-Shih; Liu, Chih-Wen; Jiang, Joe-Air; Chuang, Cheng-Long; Teng, Ming-Tsung

    2012-07-01

    This paper presents a novel solution of a hand-held external controller to a miniaturized capsule endoscope in the gastrointestinal (GI) tract. Traditional capsule endoscopes move passively by peristaltic wave generated in the GI tract and the gravity, which makes it impossible for endoscopists to manipulate the capsule endoscope to the diagnostic disease areas. In this study, the main objective is to present an endoscopic capsule and a magnetic field navigator (MFN) that allows endoscopists to remotely control the locomotion and viewing angle of an endoscopic capsule. The attractive merits of this study are that the maneuvering of the endoscopic capsule can be achieved by the external MFN with effectiveness, low cost, and operation safety, both from a theoretical and an experimental point of view. In order to study the magnetic interactions between the endoscopic capsule and the external MFN, a magnetic-analysis model is established for computer-based finite-element simulations. In addition, experiments are conducted to show the control effectiveness of the MFN to the endoscopic capsule. Finally, several prototype endoscopic capsules and a prototype MFN are fabricated, and their actual capabilities are experimentally assessed via in vitro and ex vivo tests using a stomach model and a resected porcine stomach, respectively. Both in vitro and ex vivo test results demonstrate great potential and practicability of achieving high-precision rotation and controllable movement of the capsule using the developed MFN.

  16. Effects of Sb-doping on the grain growth of Cu(In, Ga)Se2 thin films fabricated by means of single-target sputtering

    International Nuclear Information System (INIS)

    Zhang, Shu; Wu, Lu; Yue, Ruoyu; Yan, Zongkai; Zhan, Haoran; Xiang, Yong

    2013-01-01

    To investigate the effects of Sb doping on the kinetics of grain growth in Cu(In,Ga)Se 2 (CIGS) thin films during annealing, CIGS thin films were sputtered onto Mo coated substrates from a single CIGS alloy target, followed by chemical bath deposition of Sb 2 S 3 thin layers on top of CIGS layers and subsequent annealing at different temperatures for 30 min in Se vapors. X-ray diffraction results showed that CIGS thin films were obtained directly using the single-target sputtering method. After annealing, the In/Ga ratio in Sb-doped CIGS thin films remained stable compared to undoped film, possibly because Sb can promote the incorporation of Ga into CIGS. The grain growth in CIGS thin films was enhanced after Sb doping, exhibiting significantly larger grains after annealing at 400 °C or 450 °C compared to films without Sb. In particular, the effect was strikingly significant in grain growth across the film thickness, resulting in columnar grain structure in Sb-doped films. This grain growth improvement may be led by the diffusion of Sb from the front surface to the CIGS-Mo back interface, which promoted the mass transport process in CIGS thin films. - Highlights: ► Cu(In,Ga)Se 2 (CIGS) thin films made by sputtering from a single CIGS target. ► Chemical bath deposition used to introduce antimony into CIGS absorber layers. ► In/Ga ratio decreases in Sb-doped annealed films, comparatively to undoped films. ► Sb-doped CIGS films are superior to undoped films in terms of grain-growth kinetics

  17. Controlled expression of nif and isc iron-sulfur protein maturation components reveals target specificity and limited functional replacement between the two systems.

    Science.gov (United States)

    Dos Santos, Patricia C; Johnson, Deborah C; Ragle, Brook E; Unciuleac, Mihaela-Carmen; Dean, Dennis R

    2007-04-01

    The nitrogen-fixing organism Azotobacter vinelandii contains at least two systems that catalyze formation of [Fe-S] clusters. One of these systems is encoded by nif genes, whose products supply [Fe-S] clusters required for maturation of nitrogenase. The other system is encoded by isc genes, whose products are required for maturation of [Fe-S] proteins that participate in general metabolic processes. The two systems are similar in that they include an enzyme for the mobilization of sulfur (NifS or IscS) and an assembly scaffold (NifU or IscU) upon which [Fe-S] clusters are formed. Normal cellular levels of the Nif system, which supplies [Fe-S] clusters for the maturation of nitrogenase, cannot also supply [Fe-S] clusters for the maturation of other cellular [Fe-S] proteins. Conversely, when produced at the normal physiological levels, the Isc system cannot supply [Fe-S] clusters for the maturation of nitrogenase. In the present work we found that such target specificity for IscU can be overcome by elevated production of NifU. We also found that NifU, when expressed at normal levels, is able to partially replace the function of IscU if cells are cultured under low-oxygen-availability conditions. In contrast to the situation with IscU, we could not establish conditions in which the function of IscS could be replaced by NifS. We also found that elevated expression of the Isc components, as a result of deletion of the regulatory iscR gene, improved the capacity for nitrogen-fixing growth of strains deficient in either NifU or NifS.

  18. Synthesis, processing and characterization of shear thickening fluid (STF) impregnated fabric composites

    International Nuclear Information System (INIS)

    Hassan, Tarig A.; Rangari, Vijay K.; Jeelani, Shaik

    2010-01-01

    Shear thickening is a non-Newtonian fluid behavior defined as the increase of viscosity with the increase in the applied shear rate. The shear thickening fluid (STF) is a combination of hard metal oxide particles suspended in a liquid polymer. This mixture of flowable and hard components at a particular composition, results in a material with remarkable properties. In this manuscript the shear thickening fluid (STF) was prepared by ultrasound irradiation of silica nanoparticles dispersed in liquid polyethylene glycol polymer. The as-prepared STFs have been tested for their rheological and thermal properties. Kevlar and Nylon fabrics were soaked in STF/ethanol solution to make STF/fabric composite. Knife threats and quasistatic penetration tests were performed on the neat fabrics and STF/fabric composite targets for both engineered spike and knife on areal density basis. The results showed that STF impregnated fabrics have better penetration resistance as compared to neat fabrics without affecting the fabric flexibility. This indicates that the addition of STF to the fabric have enhanced the fabric performance and can be used in liquid body armor applications.

  19. Influence of the laser pulse repetition rate and scanning speed on the morphology of Ag nanostructures fabricated by pulsed laser ablation of solid target in water

    Science.gov (United States)

    Nikolov, A. S.; Balchev, I. I.; Nedyalkov, N. N.; Kostadinov, I. K.; Karashanova, D. B.; Atanasova, G. B.

    2017-11-01

    Nanostructures of noble metal were produced by pulsed laser ablation in liquid. A solid Ag target was immersed in double distilled water and a CuBr laser in a master oscillator—power amplifier configuration oscillating at 511 nm and emitting pulses with duration of 30 ns at a repetition rate of up to 20 kHz was employed to produce different colloids. The impact was studied of the laser pulse repetition rate and the beam scanning speed on the morphology of the nanostructures formed. Further, the optical extinction spectra of the colloids in the UV/VIS range were measured and used to make an indirect assessment of the changes in the shape and size distribution of the nanostructures. The transmission values in the near UV range were used to estimate the efficiency of the ablation process under the different experimental conditions implemented. A visualization of the nanostructures was made possible by transmission electron microscopy (TEM). The structure and phase composition of the nanoparticles were studied by high-resolution transmission electron microscopy (HRTEM) and selected area electron diffraction (SAED), while the alteration of the target surface caused by the impact of the high-repetition-rate laser illumination was investigated by X-ray photoelectron spectroscopy (XPS). The optimal conditions were determined yielding the highest efficiency in terms of amount of ablated material.

  20. In-Ga-Zn-oxide thin-film transistors with Sb2TeOx gate insulators fabricated by reactive sputtering using a metallic Sb2Te target

    International Nuclear Information System (INIS)

    Cheong, Woo-Seok

    2011-01-01

    Using reactive sputtering, we made transparent amorphous Sb 2 TeO x thin films from a metallic Sb 2 Te target in an oxidizing atmosphere. In-Ga-Zn-oxide thin-film transistors (IGZO TFTs) with Sb 2 TeO x gate insulators deposited at room temperature showed a large hysteresis with a counter clockwise direction, which was caused by mobile charges in the gate insulators. The problems of the mobile charges was solved by using Sb 2 TeO x films formed at 250 .deg. C. After the IGZO TFT had been annealed at 200 .deg. C for 1 hour in an O 2 ambient, the mobility of the IGZO TFT was 22.41 cm 2 /Vs, and the drain current on-off ratio was ∼10 8 .

  1. Target support for inertial confinement fusion

    International Nuclear Information System (INIS)

    Schultz, K.R.

    1995-08-01

    General Atomics (GA) plays an important industrial support role for the US Inertial Confinement Fusion (ICF) program in the area of target technology. This includes three major activities: target fabrication support, target handling systems development, and target chamber design. The work includes target fabrication for existing ICF experiments, target and target system development for future experiments, and target research and target chamber design for experiments on future machines, such as the National Ignition Facility (NIF)

  2. Evaluation of magnetostrictive composite coated fabric as a fragment barrier material

    International Nuclear Information System (INIS)

    Son, Kwon Joong; Fahrenthold, Eric P

    2012-01-01

    Over the last decade a surge in fragment barrier research has led to investigation of numerous materials and material augmentations in the attempt to improve the ballistic performance of systems designed to protect personnel, vehicles or infrastructure from impact and blast loads. One widely studied material augmentation approach is the use of coatings, often polymers, to enhance the performance of protection systems constructed from metal, concrete, composite and fabric materials. In recent research the authors have conducted the first experimental study of the ballistic performance of fabrics coated with a magnetically responsive polymer. Zero field impact experiments on coated fabric targets showed a 61% increase in impact energy dissipation, although the coated targets were not competitive with neat fabrics on a protection per unit mass basis. Under an applied field of 110 kA m −1 , the ballistic performance of the coated fabric was reduced. The reduction in performance may be attributed to a reduction in material damping and an increase in material modulus for the magnetostrictive component of the coating. Analysis of the coated fabric response to magnetic preloads suggests that coating tensile stresses and coating–fabric interface stresses induced by the applied field may also adversely affect ballistic performance. (paper)

  3. Selective effects of acute alcohol intake on the prospective and retrospective components of a prospective-memory task with emotional targets.

    Science.gov (United States)

    Walter, Nora T; Bayen, Ute J

    2016-01-01

    Prospective memory involves remembering to do something in the future and has a prospective component (remembering that something must be done) and a retrospective component (remembering what must be done and when it must be done). Initial studies reported an impairment in prospective-memory performance due to acute alcohol consumption. Retrospective-memory studies demonstrated that alcohol effects vary depending on the emotionality of the information that needs to be learned. The aim of the present study was to investigate possible differential effects of a mild acute alcohol dose (0.4 g/kg) on the prospective and retrospective components of prospective memory depending on cue valence. Seventy-five participants were allocated to an alcohol or placebo group and performed a prospective-memory task in which prospective-memory cue valence was manipulated (negative, neutral, positive). The multinomial model of event-based prospective memory (Smith and Bayen 2004) was used to measure alcohol and valence effects on the two prospective-memory components separately. Overall, no main effect of alcohol or valence on prospective-memory performance occurred. However, model-based analyses demonstrated a significantly higher retrospective component for positive compared with negative cues in the placebo group. In the alcohol group, the prospective component was weaker for negative than for neutral cues and the retrospective component was stronger for positive than for neutral cues. Group comparisons showed that the alcohol group had a significantly lower prospective component for negative cues and a lower retrospective component for neutral cues. This is the first study to demonstrate selective alcohol effects on prospective-memory components depending on prospective-memory cue valence.

  4. Replaceable LMFBR core components

    International Nuclear Information System (INIS)

    Evans, E.A.; Cunningham, G.W.

    1976-01-01

    Much progress has been made in understanding material and component performance in the high temperature, fast neutron environment of the LMFBR. Current data have provided strong assurance that the initial core component lifetime objectives of FFTF and CRBR can be met. At the same time, this knowledge translates directly into the need for improved core designs that utilize improved materials and advanced fuels required to meet objectives of low doubling times and extended core component lifetimes. An industrial base for the manufacture of quality core components has been developed in the US, and all procurements for the first two core equivalents for FFTF will be completed this year. However, the problem of fabricating recycled plutonium while dramatically reducing fabrication costs, minimizing personnel exposure, and protecting public health and safety must be addressed

  5. Status report, canister fabrication

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, Claes-Goeran; Eriksson, Peter; Westman, Marika [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden); Emilsson, Goeran [CSM Materialteknik AB, Linkoeping (Sweden)

    2004-06-01

    The report gives an account of the development of material and fabrication technology for copper canisters with cast inserts during the period from 2000 until the start of 2004. The engineering design of the canister and the choice of materials in the constituent components described in previous status reports have not been significantly changed. In the reference canister, the thickness of the copper shell is 50 mm. Fabrication of individual components with a thinner copper thickness is done for the purpose of gaining experience and evaluating fabrication and inspection methods for such canisters. As a part of the development of cast inserts, computer simulations of the casting processes and techniques used at the foundries have been performed for the purpose of optimizing the material properties. These properties have been evaluated by extensive tensile testing and metallographic inspection of test material taken from discs cut at different points along the length of the inserts. The testing results exhibit a relatively large spread. Low elongation values in certain tensile test specimens are due to the presence of poorly formed graphite, porosities, slag or other casting defects. It is concluded in the report that it will not be possible to avoid some presence of observed defects in castings of this size. In the deep repository, the inserts will be exposed to compressive loading and the observed defects are not critical for strength. An analysis of the strength of the inserts and formulation of relevant material requirements must be based on a statistical approach with probabilistic calculations. This work has been initiated and will be concluded during 2004. An initial verifying compression test of a canister in an isostatic press has indicated considerable overstrength in the structure. Seamless copper tubes are fabricated by means of three methods: extrusion, pierce and draw processing, and forging. It can be concluded that extrusion tests have revealed a

  6. Status report, canister fabrication

    International Nuclear Information System (INIS)

    Andersson, Claes-Goeran; Eriksson, Peter; Westman, Marika; Emilsson, Goeran

    2004-06-01

    The report gives an account of the development of material and fabrication technology for copper canisters with cast inserts during the period from 2000 until the start of 2004. The engineering design of the canister and the choice of materials in the constituent components described in previous status reports have not been significantly changed. In the reference canister, the thickness of the copper shell is 50 mm. Fabrication of individual components with a thinner copper thickness is done for the purpose of gaining experience and evaluating fabrication and inspection methods for such canisters. As a part of the development of cast inserts, computer simulations of the casting processes and techniques used at the foundries have been performed for the purpose of optimizing the material properties. These properties have been evaluated by extensive tensile testing and metallographic inspection of test material taken from discs cut at different points along the length of the inserts. The testing results exhibit a relatively large spread. Low elongation values in certain tensile test specimens are due to the presence of poorly formed graphite, porosities, slag or other casting defects. It is concluded in the report that it will not be possible to avoid some presence of observed defects in castings of this size. In the deep repository, the inserts will be exposed to compressive loading and the observed defects are not critical for strength. An analysis of the strength of the inserts and formulation of relevant material requirements must be based on a statistical approach with probabilistic calculations. This work has been initiated and will be concluded during 2004. An initial verifying compression test of a canister in an isostatic press has indicated considerable overstrength in the structure. Seamless copper tubes are fabricated by means of three methods: extrusion, pierce and draw processing, and forging. It can be concluded that extrusion tests have revealed a

  7. Adaptive Control of Freeze-Form Extrusion Fabrication Processes (Preprint)

    National Research Council Canada - National Science Library

    Zhao, Xiyue; Landers, Robert G; Leu, Ming C

    2008-01-01

    Freeze-form Extrusion Fabrication (FEF) is an additive manufacturing process that extrudes high solids loading aqueous ceramic pastes in a layer-by-layer fashion below the paste freezing temperature for component fabrication...

  8. Advanced fuel fabrication

    International Nuclear Information System (INIS)

    Bernard, H.

    1989-01-01

    This paper deals with the fabrication of advanced fuels, such as mixed oxides for Pressurized Water Reactors or mixed nitrides for Fast Breeder Reactors. Although an extensive production experience exists for the mixed oxides used in the FBR, important work is still needed to improve the theoretical and technical knowledge of the production route which will be introduced in the future European facility, named Melox, at Marcoule. Recently, the feasibility of nitride fuel fabrication in existing commercial oxide facilities was demonstrated in France. The process, based on carbothermic reduction of oxides with subsequent comminution of the reaction product, cold pressing and sintering provides (U, Pu)N pellets with characteristics suitable for irradiation testing. Two experiments named NIMPHE 1 and 2 fabricated in collaboration with ITU, Karlsruhe, involve 16 nitride and 2 carbide pins, operating at a linear power of 45 and 73 kW/m with a smear density of 75-80% TD and a high burn-up target of 15 at%. These experiments are currently being irradiated in Phenix, at Marcoule. (orig.)

  9. The exosome component Rrp6 is required for RNA polymerase II termination at specific targets of the Nrd1-Nab3 pathway.

    Science.gov (United States)

    Fox, Melanie J; Gao, Hongyu; Smith-Kinnaman, Whitney R; Liu, Yunlong; Mosley, Amber L

    2015-01-01

    The exosome and its nuclear specific subunit Rrp6 form a 3'-5' exonuclease complex that regulates diverse aspects of RNA biology including 3' end processing and degradation of a variety of noncoding RNAs (ncRNAs) and unstable transcripts. Known targets of the nuclear exosome include short (Polymerase II (RNAPII) localization. Deletion of RRP6 promotes hyper-elongation of multiple NNS-dependent transcripts resulting from both improperly processed 3' RNA ends and faulty transcript termination at specific target genes. The defects in RNAPII termination cause transcriptome-wide changes in mRNA expression through transcription interference and/or antisense repression, similar to previously reported effects of depleting Nrd1 from the nucleus. Elongated transcripts were identified within all classes of known NNS targets with the largest changes in transcription termination occurring at CUTs. Interestingly, the extended transcripts that we have detected in our studies show remarkable similarity to Nrd1-unterminated transcripts at many locations, suggesting that Rrp6 acts with the NNS complex globally to promote transcription termination in addition to 3' end RNA processing and/or degradation at specific targets.

  10. Differential Targeting of Hsp70 Heat Shock Proteins HSPA6 and HSPA1A with Components of a Protein Disaggregation/Refolding Machine in Differentiated Human Neuronal Cells following Thermal Stress

    Directory of Open Access Journals (Sweden)

    Ian R. Brown

    2017-04-01

    Full Text Available Heat shock proteins (Hsps co-operate in multi-protein machines that counter protein misfolding and aggregation and involve DNAJ (Hsp40, HSPA (Hsp70, and HSPH (Hsp105α. The HSPA family is a multigene family composed of inducible and constitutively expressed members. Inducible HSPA6 (Hsp70B' is found in the human genome but not in the genomes of mouse and rat. To advance knowledge of this little studied HSPA member, the targeting of HSPA6 to stress-sensitive neuronal sites with components of a disaggregation/refolding machine was investigated following thermal stress. HSPA6 targeted the periphery of nuclear speckles (perispeckles that have been characterized as sites of transcription. However, HSPA6 did not co-localize at perispeckles with DNAJB1 (Hsp40-1 or HSPH1 (Hsp105α. At 3 h after heat shock, HSPA6 co-localized with these members of the disaggregation/refolding machine at the granular component (GC of the nucleolus. Inducible HSPA1A (Hsp70-1 and constitutively expressed HSPA8 (Hsc70 co-localized at nuclear speckles with components of the machine immediately after heat shock, and at the GC layer of the nucleolus at 1 h with DNAJA1 and BAG-1. These results suggest that HSPA6 exhibits targeting features that are not apparent for HSPA1A and HSPA8.

  11. An Ethology of Urban Fabric(s)

    DEFF Research Database (Denmark)

    Fritsch, Jonas; Thomsen, Bodil Marie Stavning

    2014-01-01

    The article explores a non-metaphorical understanding of urban fabric(s), shifting the attention from a bird’s eye perspective to the actual, textural manifestations of a variety of urban fabric(s) to be studied in their real, processual, ecological and ethological complexity within urban life. We...... effectuate this move by bringing into resonance a range of intersecting fields that all deal with urban fabric(s) in complementary ways (interaction design and urban design activism, fashion, cultural theory, philosophy, urban computing)....

  12. 10-Hydroxy-2-decenoic Acid, the Major Lipid Component of Royal Jelly, Extends the Lifespan of Caenorhabditis elegans through Dietary Restriction and Target of Rapamycin Signaling

    OpenAIRE

    Honda, Yoko; Araki, Yoko; Hata, Taketoshi; Ichihara, Kenji; Ito, Masafumi; Tanaka, Masashi; Honda, Shuji

    2015-01-01

    Royal jelly (RJ) produced by honeybees has been reported to possess diverse health-beneficial properties and has been implicated to have a function in longevity across diverse species as well as honeybees. 10-Hydroxy-2-decenoic acid (10-HDA), the major lipid component of RJ produced by honeybees, was previously shown to increase the lifespan of Caenorhabditis elegans. The objective of this study is to elucidate signaling pathways that are involved in the lifespan extension by 10-HDA. 10-HDA f...

  13. The exosome component Rrp6 is required for RNA polymerase II termination at specific targets of the Nrd1-Nab3 pathway.

    Directory of Open Access Journals (Sweden)

    Melanie J Fox

    Full Text Available The exosome and its nuclear specific subunit Rrp6 form a 3'-5' exonuclease complex that regulates diverse aspects of RNA biology including 3' end processing and degradation of a variety of noncoding RNAs (ncRNAs and unstable transcripts. Known targets of the nuclear exosome include short (<1000 bp RNAPII transcripts such as small noncoding RNAs (snRNAs, cryptic unstable transcripts (CUTs, and some stable unannotated transcripts (SUTs that are terminated by an Nrd1, Nab3, and Sen1 (NNS dependent mechanism. NNS-dependent termination is coupled to RNA 3' end processing and/or degradation by the Rrp6/exosome in yeast. Recent work suggests Nrd1 is necessary for transcriptome surveillance, regulating promoter directionality and suppressing antisense transcription independently of, or prior to, Rrp6 activity. It remains unclear whether Rrp6 is directly involved in termination; however, Rrp6 has been implicated in the 3' end processing and degradation of ncRNA transcripts including CUTs. To determine the role of Rrp6 in NNS termination globally, we performed RNA sequencing (RNA-Seq on total RNA and perform ChIP-exo analysis of RNA Polymerase II (RNAPII localization. Deletion of RRP6 promotes hyper-elongation of multiple NNS-dependent transcripts resulting from both improperly processed 3' RNA ends and faulty transcript termination at specific target genes. The defects in RNAPII termination cause transcriptome-wide changes in mRNA expression through transcription interference and/or antisense repression, similar to previously reported effects of depleting Nrd1 from the nucleus. Elongated transcripts were identified within all classes of known NNS targets with the largest changes in transcription termination occurring at CUTs. Interestingly, the extended transcripts that we have detected in our studies show remarkable similarity to Nrd1-unterminated transcripts at many locations, suggesting that Rrp6 acts with the NNS complex globally to promote

  14. Synthesis of Some Novel Biologically Active Disperse Dyes Derived from 4-Methyl-2,6-dioxo-1-propyl-1,2,5,6-tetrahydro-pyridine-3-carbonitrile as Coupling Component and Their Colour Assessment on Polyester Fabrics

    Directory of Open Access Journals (Sweden)

    Mohamed H. Elnagdi

    2012-07-01

    Full Text Available A series of novel azo-disperse dyes containing alkylhydrazonopyridinone structures were synthesized. 4-Methyl-2,6-dioxo-1-propyl-1,2,5,6-tetrahydropyridine-3-carbonitrile (8 is synthesized by one-pot synthesis using ethyl cyanoacetate, propylamine, and ethyl acetoacetate. Compound 8 is then coupled with aromatic and heteroaromatic diazonium salts to afford the corresponding aryl- and heteroaryl-4-methyl-2,6-dioxo-1-propyl-1,2,5,6-tetrahydropyridine-3-carbonitriles 12a,b and 13a–c. Structural assignments to the dyes were made using NMR spectroscopic methods. A high temperature dyeing method was employed to apply these dyes to polyester fabrics. Most of the dyed fabrics tested displayed very good light fastness levels and good wash fastness. Finally, the biological activity of the prepared dyes against Gram positive bacteria and Gram negative bacteria were evaluated.

  15. Swift fabrication of Ag nanostructures using a colloidal solution of Holostemma ada-kodien (Apocynaceae) - Antibiofilm potential, insecticidal activity against mosquitoes and non-target impact on water bugs.

    Science.gov (United States)

    Alyahya, Sami A; Govindarajan, Marimuthu; Alharbi, Naiyf S; Kadaikunnan, Shine; Khaled, Jamal M; Mothana, Ramzi A; Al-Anbr, Mohammed N; Vaseeharan, Baskaralingam; Ishwarya, Ramachandran; Yazhiniprabha, Mariappan; Benelli, Giovanni

    2018-04-01

    Recent research in entomology and parasitology focused on the efficacy of green fabricated nanomaterials as novel insecticides. In this study, we synthesized poly-dispersed and stable silver nanoparticles (AgNPs) using the leaf extract of Holostemma ada-kodien. The nanostructures were characterized by ultraviolet-visible spectroscopy, Fourier-transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, energy dispersive X-ray, and X-ray diffraction analysis. The efficacy of H. ada-kodien leaf extract and AgNPs in vector control was evaluated against the mosquitoes Anopheles stephensi, Aedes aegypti, and Culex quinquefasciatus, which act as major vectors of important parasitic and arboviral diseases. AgNPs showed higher toxicity if compared to the H. ada-kodien leaf aqueous extract, LC 50 towards larvae of A. stephensi, A. aegypti, and C. quinquefasciatus were 12.18, 13.30, and 14.70 μg/mL, respectively. When the AgNPs were tested on non-target water bugs, Diplonychus indicus, the LC 50 value was 623.48 μg/mL. Furthermore, 100 μl/mL of AgNPs achieved significant antimicrobial activity against Bacillus pumilus, Enterococcus faecalis, Pseudomonas aeruginosa, Proteus vulgaris, and Candida albicans. Light and confocal laser scanning microscopy highlighted a major impact of the H. ada-kodien-synthesized AgNPs on the external topography and architecture of microbial biofilms, both on Gram-positive and Gram-negative bacteria. Overall, this study sheds light on the insecticidal and antibiofilm potential of H. ada-kodien-synthesized AgNPs, a potential green resource for the rapid synthesis of polydispersed and highly stable AgNPs. Copyright © 2018 Elsevier B.V. All rights reserved.

  16. Fabrication and Prototyping Lab

    Data.gov (United States)

    Federal Laboratory Consortium — Purpose: The Fabrication and Prototyping Lab for composite structures provides a wide variety of fabrication capabilities critical to enabling hands-on research and...

  17. Fabrication of recyclable superhydrophobic cotton fabrics

    Science.gov (United States)

    Han, Sang Wook; Park, Eun Ji; Jeong, Myung-Geun; Kim, Il Hee; Seo, Hyun Ook; Kim, Ju Hwan; Kim, Kwang-Dae; Kim, Young Dok

    2017-04-01

    Commercial cotton fabric was coated with SiO2 nanoparticles wrapped with a polydimethylsiloxane (PDMS) layer, and the resulting material surface showed a water contact angle greater than 160°. The superhydrophobic fabric showed resistance to water-soluble contaminants and maintained its original superhydrophobic properties with almost no alteration even after many times of absorption-washing cycles of oil. Moreover, superhydrophobic fabric can be used as a filter to separate oil from water. We demonstrated a simple method of fabrication of superhydrophobic fabric with potential interest for use in a variety of applications.

  18. Device for irradiation of a target surface by a variable electron beam, especially electron beam generator, in order to produce semiconductor components

    International Nuclear Information System (INIS)

    Wolfe, J.E.

    1978-01-01

    For the lithographic device there is used a field emission source for thermal ions with a tungsten cathode and a zirconium top as an electron gain. For production of IC chips the electron beam of 1000 A/cm 2 can be focused on a mask template, mounted on a x/Y table, by means of a system of lenses. The electromagnetic focusing device with a small aberration coefficient is designed in such a way that there is obtained a large focal length on the image side as compared to the focal length on the object side. Thereby a small angular deflection of the beam in the focusing device causes a large deflection at the target. The control is performed by a processor. (RW) [de

  19. Hsp90 inhibition differentially destabilises MAP kinase and TGF-beta signalling components in cancer cells revealed by kinase-targeted chemoproteomics

    International Nuclear Information System (INIS)

    Haupt, Armin; Dahl, Andreas; Lappe, Michael; Lehrach, Hans; Gonzalez, Cayetano; Drewes, Gerard; Lange, Bodo MH; Joberty, Gerard; Bantscheff, Marcus; Fröhlich, Holger; Stehr, Henning; Schweiger, Michal R; Fischer, Axel; Kerick, Martin; Boerno, Stefan T

    2012-01-01

    The heat shock protein 90 (Hsp90) is required for the stability of many signalling kinases. As a target for cancer therapy it allows the simultaneous inhibition of several signalling pathways. However, its inhibition in healthy cells could also lead to severe side effects. This is the first comprehensive analysis of the response to Hsp90 inhibition at the kinome level. We quantitatively profiled the effects of Hsp90 inhibition by geldanamycin on the kinome of one primary (Hs68) and three tumour cell lines (SW480, U2OS, A549) by affinity proteomics based on immobilized broad spectrum kinase inhibitors ('kinobeads'). To identify affected pathways we used the KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway classification. We combined Hsp90 and proteasome inhibition to identify Hsp90 substrates in Hs68 and SW480 cells. The mutational status of kinases from the used cell lines was determined using next-generation sequencing. A mutation of Hsp90 candidate client RIPK2 was mapped onto its structure. We measured relative abundances of > 140 protein kinases from the four cell lines in response to geldanamycin treatment and identified many new potential Hsp90 substrates. These kinases represent diverse families and cellular functions, with a strong representation of pathways involved in tumour progression like the BMP, MAPK and TGF-beta signalling cascades. Co-treatment with the proteasome inhibitor MG132 enabled us to classify 64 kinases as true Hsp90 clients. Finally, mutations in 7 kinases correlate with an altered response to Hsp90 inhibition. Structural modelling of the candidate client RIPK2 suggests an impact of the mutation on a proposed Hsp90 binding domain. We propose a high confidence list of Hsp90 kinase clients, which provides new opportunities for targeted and combinatorial cancer treatment and diagnostic applications

  20. Safety and environmental advantages of using tritium-lean targets for inertial fusion

    International Nuclear Information System (INIS)

    Arzeni, S.; Latkowski, J. F.; Logan, B. G.; Meier, W. R.; Moir, R. W.; Perkins, L. J.; Sanz, J.

    1999-01-01

    While traditional inertial fusion energy target designs typically use equimolar portions of deuterium and tritium and have areal densities (ρr) of ∼ 3 g/cm 2 , significant safety and environmental (S and E) advantages may be obtained through the use of high-density (ρr ∼ 10 g/cm 2 ) targets with tritium components as low as 0.5%. Such targets would absorb much of the neutron energy within the target and could be self-sufficient from a tritium breeding point of view. Tritium self-sufficiency within the target would free target chamber designers from the need to use lithium-bearing blanket materials, while low inventories within each target would translate into low inventories in target fabrication facilities. Absorption of much of the neutron energy within the target, the extremely low tritium inventories, and the greatly moderated neutron spectrum, make ''tritium-lean'' targets appear quite attractive from an S and E perspective

  1. Assimilation of MODIS Dark Target and Deep Blue Observations in the Dust Aerosol Component of NMMB-MONARCH version 1.0

    Science.gov (United States)

    Di Tomaso, Enza; Schutgens, Nick A. J.; Jorba, Oriol; Perez Garcia-Pando, Carlos

    2017-01-01

    A data assimilation capability has been built for the NMMB-MONARCH chemical weather prediction system, with a focus on mineral dust, a prominent type of aerosol. An ensemble-based Kalman filter technique (namely the local ensemble transform Kalman filter - LETKF) has been utilized to optimally combine model background and satellite retrievals. Our implementation of the ensemble is based on known uncertainties in the physical parametrizations of the dust emission scheme. Experiments showed that MODIS AOD retrievals using the Dark Target algorithm can help NMMB-MONARCH to better characterize atmospheric dust. This is particularly true for the analysis of the dust outflow in the Sahel region and over the African Atlantic coast. The assimilation of MODIS AOD retrievals based on the Deep Blue algorithm has a further positive impact in the analysis downwind from the strongest dust sources of the Sahara and in the Arabian Peninsula. An analysis-initialized forecast performs better (lower forecast error and higher correlation with observations) than a standard forecast, with the exception of underestimating dust in the long-range Atlantic transport and degradation of the temporal evolution of dust in some regions after day 1. Particularly relevant is the improved forecast over the Sahara throughout the forecast range thanks to the assimilation of Deep Blue retrievals over areas not easily covered by other observational datasets.The present study on mineral dust is a first step towards data assimilation with a complete aerosol prediction system that includes multiple aerosol species.

  2. Genome comparison of barley and maize smut fungi reveals targeted loss of RNA silencing components and species-specific presence of transposable elements.

    Science.gov (United States)

    Laurie, John D; Ali, Shawkat; Linning, Rob; Mannhaupt, Gertrud; Wong, Philip; Güldener, Ulrich; Münsterkötter, Martin; Moore, Richard; Kahmann, Regine; Bakkeren, Guus; Schirawski, Jan

    2012-05-01

    Ustilago hordei is a biotrophic parasite of barley (Hordeum vulgare). After seedling infection, the fungus persists in the plant until head emergence when fungal spores develop and are released from sori formed at kernel positions. The 26.1-Mb U. hordei genome contains 7113 protein encoding genes with high synteny to the smaller genomes of the related, maize-infecting smut fungi Ustilago maydis and Sporisorium reilianum but has a larger repeat content that affected genome evolution at important loci, including mating-type and effector loci. The U. hordei genome encodes components involved in RNA interference and heterochromatin formation, normally involved in genome defense, that are lacking in the U. maydis genome due to clean excision events. These excision events were possibly a result of former presence of repetitive DNA and of an efficient homologous recombination system in U. maydis. We found evidence of repeat-induced point mutations in the genome of U. hordei, indicating that smut fungi use different strategies to counteract the deleterious effects of repetitive DNA. The complement of U. hordei effector genes is comparable to the other two smuts but reveals differences in family expansion and clustering. The availability of the genome sequence will facilitate the identification of genes responsible for virulence and evolution of smut fungi on their respective hosts.

  3. Genome Comparison of Barley and Maize Smut Fungi Reveals Targeted Loss of RNA Silencing Components and Species-Specific Presence of Transposable Elements[W

    Science.gov (United States)

    Laurie, John D.; Ali, Shawkat; Linning, Rob; Mannhaupt, Gertrud; Wong, Philip; Güldener, Ulrich; Münsterkötter, Martin; Moore, Richard; Kahmann, Regine; Bakkeren, Guus; Schirawski, Jan

    2012-01-01

    Ustilago hordei is a biotrophic parasite of barley (Hordeum vulgare). After seedling infection, the fungus persists in the plant until head emergence when fungal spores develop and are released from sori formed at kernel positions. The 26.1-Mb U. hordei genome contains 7113 protein encoding genes with high synteny to the smaller genomes of the related, maize-infecting smut fungi Ustilago maydis and Sporisorium reilianum but has a larger repeat content that affected genome evolution at important loci, including mating-type and effector loci. The U. hordei genome encodes components involved in RNA interference and heterochromatin formation, normally involved in genome defense, that are lacking in the U. maydis genome due to clean excision events. These excision events were possibly a result of former presence of repetitive DNA and of an efficient homologous recombination system in U. maydis. We found evidence of repeat-induced point mutations in the genome of U. hordei, indicating that smut fungi use different strategies to counteract the deleterious effects of repetitive DNA. The complement of U. hordei effector genes is comparable to the other two smuts but reveals differences in family expansion and clustering. The availability of the genome sequence will facilitate the identification of genes responsible for virulence and evolution of smut fungi on their respective hosts. PMID:22623492

  4. Dynamin-like protein 1 at the Golgi complex: A novel component of the sorting/targeting machinery en route to the plasma membrane

    International Nuclear Information System (INIS)

    Bonekamp, Nina A.; Vormund, Kerstin; Jacob, Ralf; Schrader, Michael

    2010-01-01

    The final step in the liberation of secretory vesicles from the trans-Golgi network (TGN) involves the mechanical action of the large GTPase dynamin as well as conserved dynamin-independent fission mechanisms, e.g. mediated by Brefeldin A-dependent ADP-ribosylated substrate (BARS). Another member of the dynamin family is the mammalian dynamin-like protein 1 (DLP1/Drp1) that is known to constrict and tubulate membranes, and to divide mitochondria and peroxisomes. Here, we examined a potential role for DLP1 at the Golgi complex. DLP1 localized to the Golgi complex in some but not all cell lines tested, thus explaining controversial reports on its cellular distribution. After silencing of DLP1, an accumulation of the apical reporter protein YFP-GL-GPI, but not the basolateral reporter VSVG-SP-GFP at the Golgi complex was observed. A reduction in the transport of YFP-GL-GPI to the plasma membrane was confirmed by surface immunoprecipitation and TGN-exit assays. In contrast, YFP-GL-GPI trafficking was not disturbed in cells silenced for BARS, which is involved in basolateral sorting and trafficking of VSVG-SP-GFP in COS-7 cells. Our data indicate a new role for DLP1 at the Golgi complex and thus a role for DLP1 as a novel component of the apical sorting machinery at the TGN is discussed.

  5. Polymorphous computing fabric

    Science.gov (United States)

    Wolinski, Christophe Czeslaw [Los Alamos, NM; Gokhale, Maya B [Los Alamos, NM; McCabe, Kevin Peter [Los Alamos, NM

    2011-01-18

    Fabric-based computing systems and methods are disclosed. A fabric-based computing system can include a polymorphous computing fabric that can be customized on a per application basis and a host processor in communication with said polymorphous computing fabric. The polymorphous computing fabric includes a cellular architecture that can be highly parameterized to enable a customized synthesis of fabric instances for a variety of enhanced application performances thereof. A global memory concept can also be included that provides the host processor random access to all variables and instructions associated with the polymorphous computing fabric.

  6. ITER nuclear components, preparing for the construction and R and D results

    Energy Technology Data Exchange (ETDEWEB)

    Ioki, K. E-mail: iokik@itereu.de; Akiba, M.; Barabaschi, P.; Barabash, V.; Chiocchio, S.; Daenner, W.; Elio, F.; Enoeda, M.; Ezato, K.; Federici, G.; Gervash, A.; Grebennikov, D.; Jones, L.; Kajiura, S.; Krylov, V.; Kuroda, T.; Lorenzetto, P.; Maruyama, S.; Merola, M.; Miki, N.; Morimoto, M.; Nakahira, M.; Ohmori, J.; Onozuka, M.; Rozov, V.; Sato, K.; Strebkov, Yu.; Suzuki, S.; Tanchuk, V.; Tivey, R.; Utin, Yu

    2004-08-01

    Progress has been made in the preparation of the procurement specifications for key nuclear components of ITER. Detailed design of the vacuum vessel (VV) and in-vessel components is being performed to consider fabrication methods and non-destructive tests (NDT). R and D activities are being carried out on vacuum vessel UT inspection with waves launched at an angle of 20 deg. or 30 deg. , on flow distribution tests of a two-channel model, on fabrication and testing of FW mock-ups and panels, on the blanket flexible support as a complete system including the housing, on the blanket co-axial pipe connection with guard vacuum for leak detection, and on divertor vertical target prototypes. The results give confidence in the validity of the design and identify possibilities of attractive alternate fabrication methods.

  7. ITER nuclear components, preparing for the construction and R&D results

    Science.gov (United States)

    Ioki, K.; Akiba, M.; Barabaschi, P.; Barabash, V.; Chiocchio, S.; Daenner, W.; Elio, F.; Enoeda, M.; Ezato, K.; Federici, G.; Gervash, A.; Grebennikov, D.; Jones, L.; Kajiura, S.; Krylov, V.; Kuroda, T.; Lorenzetto, P.; Maruyama, S.; Merola, M.; Miki, N.; Morimoto, M.; Nakahira, M.; Ohmori, J.; Onozuka, M.; Rozov, V.; Sato, K.; Strebkov, Yu; Suzuki, S.; Tanchuk, V.; Tivey, R.; Utin, Yu

    2004-08-01

    Progress has been made in the preparation of the procurement specifications for key nuclear components of ITER. Detailed design of the vacuum vessel (VV) and in-vessel components is being performed to consider fabrication methods and non-destructive tests (NDT). R&D activities are being carried out on vacuum vessel UT inspection with waves launched at an angle of 20° or 30°, on flow distribution tests of a two-channel model, on fabrication and testing of FW mock-ups and panels, on the blanket flexible support as a complete system including the housing, on the blanket co-axial pipe connection with guard vacuum for leak detection, and on divertor vertical target prototypes. The results give confidence in the validity of the design and identify possibilities of attractive alternate fabrication methods.

  8. Relationship between the Physical Properties and Hand of Jean Fabric

    Directory of Open Access Journals (Sweden)

    Kawamura Atsushi

    2016-09-01

    Full Text Available We investigated the distinctive characteristics of jean fabrics (denim fabrics obtained from jeans and compared the physical properties and the hand. We used 13 kinds of jean fabric from commercial jeans and 26 other fabric types. The physical properties were measured using the Kawabata evaluation system, and the fabric hand was evaluated by 20 subjects using a semantic differential method. To characterise the hand of jean fabrics compared with other fabrics, we used principal component analysis and obtained three principal components. We found that jean fabrics were characterised by the second principal component, which was affected by feelings of thickness and weight. We further characterised the jean fabrics according to ‘softness & smoothness’ and ‘non-fullness’, depending on country of origin and type of manufacturer. The three principal components were analysed using multiple linear regression to characterise the components according to the physical properties. We explained the hand of fabrics including jean fabrics using its association with physical properties.

  9. Electronic components and systems

    CERN Document Server

    Dennis, W H

    2013-01-01

    Electronic Components and Systems focuses on the principles and processes in the field of electronics and the integrated circuit. Covered in the book are basic aspects and physical fundamentals; different types of materials involved in the field; and passive and active electronic components such as capacitors, inductors, diodes, and transistors. Also covered in the book are topics such as the fabrication of semiconductors and integrated circuits; analog circuitry; digital logic technology; and microprocessors. The monograph is recommended for beginning electrical engineers who would like to kn

  10. Study Protocol of MINI SALTEN: a technology-based multi-component intervention in the school environment targeting healthy habits of first grade children and their parents.

    Science.gov (United States)

    Kovalskys, Irina; Rausch Herscovici, Cecile; Indart Rougier, Paula; De Gregorio, María José; Zonis, Luciana; Orellana, Liliana

    2017-05-06

    MINI SALTEN is a program developed to increase moderate to vigorous physical activity (PA) and improve eating habits at home and school in first grade children. It aims to assess the effects of a technology family-based and PA school-based intervention. The purpose of this manuscript is to describe the protocol design and the MINISALTEN intervention. This is cluster-randomized controlled trial designed to run from July 2015 to November 2016 in 12 public schools of the city of Buenos Aires, matched for socio-demographic characteristics. The intervention is based on two main components: (a) "active breaks" (AB): implemented during school breaks by a PA instructor; (b) "virtual" (V): web-based contents delivered to the families via a multiplatform application. Using a computer generated random sequence participants are allocated to one of four intervention conditions: (AB), (V), (AB + V), and control (C). Outcomes are measured at baseline and 12 months post intervention, and will include data collected from the child and her/his mother/father or guardian. Primary outcome measures are: PA and sedentary behaviour (measured with accelerometers). Secondary outcome measures related are: percentage of kilocalories (kcal) from added sugars, and from total and saturated fats; grams of fruits and vegetables; and number of snacks and kcal coming from their added sugars and total and saturated fats. Family socio-economic level, home environment, and school environment will also be assessed. Statistical analysis is on an intention-to-treat principle. Baseline characteristics are described using summary measures and mixed models (with school as random effect). The effect of the two interventions will be estimated using a generalized mixed linear model with link and distribution selected according to the type of outcome. Included random effects are: child (or mother/father or guardian) accounting for repeated measures; school accounting for cluster induced by school. The most

  11. ITER Central Solenoid Module Fabrication

    Energy Technology Data Exchange (ETDEWEB)

    Smith, John [General Atomics, San Diego, CA (United States)

    2016-09-23

    The fabrication of the modules for the ITER Central Solenoid (CS) has started in a dedicated production facility located in Poway, California, USA. The necessary tools have been designed, built, installed, and tested in the facility to enable the start of production. The current schedule has first module fabrication completed in 2017, followed by testing and subsequent shipment to ITER. The Central Solenoid is a key component of the ITER tokamak providing the inductive voltage to initiate and sustain the plasma current and to position and shape the plasma. The design of the CS has been a collaborative effort between the US ITER Project Office (US ITER), the international ITER Organization (IO) and General Atomics (GA). GA’s responsibility includes: completing the fabrication design, developing and qualifying the fabrication processes and tools, and then completing the fabrication of the seven 110 tonne CS modules. The modules will be shipped separately to the ITER site, and then stacked and aligned in the Assembly Hall prior to insertion in the core of the ITER tokamak. A dedicated facility in Poway, California, USA has been established by GA to complete the fabrication of the seven modules. Infrastructure improvements included thick reinforced concrete floors, a diesel generator for backup power, along with, cranes for moving the tooling within the facility. The fabrication process for a single module requires approximately 22 months followed by five months of testing, which includes preliminary electrical testing followed by high current (48.5 kA) tests at 4.7K. The production of the seven modules is completed in a parallel fashion through ten process stations. The process stations have been designed and built with most stations having completed testing and qualification for carrying out the required fabrication processes. The final qualification step for each process station is achieved by the successful production of a prototype coil. Fabrication of the first

  12. Zircaloy 4 ingots' industrial fabrication

    International Nuclear Information System (INIS)

    Leyt, A.

    1987-01-01

    The technology developed for the industrial fabrication of Zircaloy-4 ingots is presented. According to the results obtained: a) the homogeneity of the ingots is analyzed, regarding the distribution of components (tin, iron, chromium, oxygen) and Brinell hardness as a function of different types of charge: zirconium sponge-recycling alloy material, sponge of zirconium-alloy; b) the distribution of the same parameters as a function of production is also analyzed. (Author)

  13. Other components

    International Nuclear Information System (INIS)

    Anon.

    1993-01-01

    This chapter includes descriptions of electronic and mechanical components which do not merit a chapter to themselves. Other hardware requires mention because of particularly high tolerance or intolerance of exposure to radiation. A more systematic analysis of radiation responses of structures which are definable by material was given in section 3.8. The components discussed here are field effect transistors, transducers, temperature sensors, magnetic components, superconductors, mechanical sensors, and miscellaneous electronic components

  14. Stirling Microregenerators Fabricated and Tested

    Science.gov (United States)

    Moran, Matthew E.

    2004-01-01

    A mesoscale Stirling refrigerator patented by the NASA Glenn Research Center is currently under development. This refrigerator has a predicted efficiency of 30 percent of Carnot and potential uses in electronics, sensors, optical and radiofrequency systems, microarrays, and microsystems. The mesoscale Stirling refrigerator is most suited to volume-limited applications that require cooling below the ambient or sink temperature. Primary components of the planar device include two diaphragm actuators that replace the pistons found in traditional-scale Stirling machines and a microregenerator that stores and releases thermal energy to the working gas during the Stirling cycle. Diaphragms are used to eliminate frictional losses and bypass leakage concerns associated with pistons, while permitting reversal of the hot and cold sides of the device during operation to allow precise temperature control. Three candidate microregenerators were fabricated under NASA grants for initial evaluation: two constructed of porous ceramic, which were fabricated by Johns Hopkins Applied Physics Laboratory, and one made of multiple layers of nickel and photoresist, which was fabricated by Polar Thermal Technologies. The candidate regenerators are being tested by Johns Hopkins Applied Physics in a custom piezoelectric-actuated test apparatus designed to produce the Stirling refrigeration cycle. In parallel with the regenerator testing, Johns Hopkins is using deep reactive ion etching to fabricate electrostatically driven, comb-drive diaphragm actuators. These actuators will drive the Stirling cycle in the prototype device. The top photograph shows the porous ceramic microregenerators. Two microregenerators were fabricated with coarse pores and two with fine pores. The bottom photograph shows the test apparatus parts for evaluating the microregenerators, including the layered nickel-and-photoresist regenerator fabricated using LIGA techniques.

  15. Targeting the inflammatory component of schizophrenia

    NARCIS (Netherlands)

    H. Rahmoune (Hassan); L.W. Harris (Laura); P.C. Guest (Paul); S. Bahn (Sabine)

    2013-01-01

    textabstractSchizophrenia is a heterogeneous disease characterised by an array of clinical manifestations. A large number of studies over the last 20 years have pointed towards immune system abnormalities in patients suffering from this condition. In addition, the psychosis and cognitive dysfunction

  16. Electronic components

    CERN Document Server

    Colwell, Morris A

    1976-01-01

    Electronic Components provides a basic grounding in the practical aspects of using and selecting electronics components. The book describes the basic requirements needed to start practical work on electronic equipment, resistors and potentiometers, capacitance, and inductors and transformers. The text discusses semiconductor devices such as diodes, thyristors and triacs, transistors and heat sinks, logic and linear integrated circuits (I.C.s) and electromechanical devices. Common abbreviations applied to components are provided. Constructors and electronics engineers will find the book useful

  17. Fabrication of targets for transmutation of americium : synthesis of inertial matrix by sol-gel method. Procedure study on the infiltration of a radioactive solutions; Fabricacion de blancos para la transmutacion de americio: sintesis de matrices inertes por el metodo sol-gel. Estudio del procedimiento de infiltracion de disoluciones radiactivas

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez Carretero, A [Universidad Complutense de Madrid (Spain)

    2002-07-01

    Transmutation and incineration are innovative options in the management and disposal of fission products and actinides. nevertheless, the fabrication of targets for transmutation and incineration of actinides and fission products require a reconsideration of conventional processes (mechanical blending) and the development of new procedures compatible with the high activity of these materials. This work presents th R and D of a new fabrication method called INRAM (Infiltration of Radioactive Materials) based on the infiltration of an actinide solution in a porous non radiotoxic material in the form of a pellet (up to 12% An), or beads (up to 40% An) produced by sol-gel. The first method have been used for the fabrication of spinel (MgAl{sub 2}O{sub 4}) targets containing 11% Am, which have been irradiated in HFR-Petten (358.4 full power days). Post-test burn-up calculations showed that at the end of the irradiation the initial Am-241 concentration was reduced to 4%. The fraction of the initial americum atoms that have been fissioned is 28%. The main advantage of the INRAM method is that matrices with low or zero activity can be fabricated and formed into the required shape in an unshielded facility. This method offers other advantages over conventional ones, such as the active wastes are reduced, is easy to automate, adoptable to telemanipulation and dust free, which facilitate operator intervention and minimise radiation exposure to the personal. In addition, the infiltrant needs only be present in liquid form, i. e. it could be transferred directly from the reprocessing plant for fabrication into targets without conversion into-solid form. In order to optimise the infiltration process in depth investigations of all important process parameters, e. g. infiltration kinetics and metal (pu, Am) concentration in the feed solution, and also on extensive study or powder metallurgy parameters for the preparation of high quality fuel pellets with a high density, have been

  18. Fabrication of divertor cassette for ITER

    International Nuclear Information System (INIS)

    Sanguinetti, G.P.

    2008-01-01

    The Divertor is the component located on the bottom of the ITER vacuum vessel, whose main function is to adsorb the high thermal flux generated by the plasma whilst keeping the plasma impurity at a reasonable low level. The divertor consist of 54 units, each comprising outer components, facing the plasma and a component supporting the plasma facing components (PFC) and providing coolant distribution to them (divertor cassette). The divertor cassette is a box structure, butt welded and machined, made from plates and forgins of austenitic stainless steels. The cassette fabrication, which is in detail described, includes manufacturing of the attachments of the PFC to the cassette, the coolant distribution channels, and the cassette to vacuum vessel locking system. The divertor cassette is a pressure component (the cooling water runs at 40 bar) and therefore divertor cassette design, fabrication and service shall comply with the European PED and the applicable French law for the ITER. (orig.)

  19. Electronic components and technology

    CERN Document Server

    Sangwine, Stephen

    2007-01-01

    Most introductory textbooks in electronics focus on the theory while leaving the practical aspects to be covered in laboratory courses. However, the sooner such matters are introduced, the better able students will be to include such important concerns as parasitic effects and reliability at the very earliest stages of design. This philosophy has kept Electronic Components and Technology thriving for two decades, and this completely updated third edition continues the approach with a more international outlook.Not only does this textbook introduce the properties, behavior, fabrication, and use

  20. Targets development at Sandia National Laboratories

    International Nuclear Information System (INIS)

    Smith, M.L.; Hebron, D.; Derzon, M.; Olson, R.; Alberts, T.

    1997-01-01

    For many years, Sandia National Laboratories under contract to the Department of Energy has produced targets designed to understand complex ion beam and z-pinch plasma physics. This poster focuses on the features of target designs that make them suitable for Z-pinch plasma physics applications. Precision diagnostic targets will prove critical in understanding the plasma physics model needed for future ion beam and z-pinch design. Targets are designed to meet specific physics needs; in this case the authors have fabricated targets to maximize information about the end-on versus side-on x-ray emission and z-pinch hohlraum development. In this poster, they describe the fabrication and characterization techniques. They include discussion of current targets under development as well as target fabrication capabilities. Advanced target designs are fabricated by Sandia National Laboratories in cooperation with General Atomics of San Diego, CA and W.J. Schafer Associates, Inc. of Livermore, CA

  1. Project and supply agreement. The text of the agreement of 15 January 1993 between the International Atomic Energy Agency and the Government of the Republic of Indonesia and the Government of the United States of America concerning the transfer of enriched uranium for the fabrication of targets for the production of radioisotopes for medical purposes

    International Nuclear Information System (INIS)

    1994-08-01

    The text of the Project and Supply Agreement, which was approved by the Agency's Board of Governors on 4 December 1992 and concluded on 15 January 1993 between the Agency and the Governments of the Republic of Indonesia and the United States of America for the transfer of enriched uranium for the fabrication of targets for the production of radioisotopes for medical purposes is reproduced herein for the information of all Members. The agreement entered into force on 15 January 1993, pursuant to Article XII.1

  2. Current progress in NIF target concepts

    International Nuclear Information System (INIS)

    Gobby, P.L.; Foreman, L.R.; Thoma, D.J.; Jacobson, L.A.; Hollis, R.V.; Barrera, J.; Mitchell, M.A.; Salazar, M.A.; Salzer, L.J.

    1996-01-01

    Target concepts for the National Ignition Facility (NIF) require progress in the art and science of target fabrication. Three distinct issues are addressed: beryllium fuel capsules, foam-buffered direct drive, and high-density gas-filled hohlraums. In all cases experiments on the existing Nova laser at LLNL are either in progress or planned for the near future to test the various concepts. Consequently, target fabrication must be able to deliver targets appropriate for each

  3. Fabrication and calibration of FORTIS

    Science.gov (United States)

    Fleming, Brian T.; McCandliss, Stephan R.; Kaiser, Mary Elizabeth; Kruk, Jeffery; Feldman, Paul D.; Kutyrev, Alexander S.; Li, Mary J.; Rapchun, David A.; Lyness, Eric; Moseley, S. H.; Siegmund, Oswald; Vallerga, John; Martin, Adrian

    2011-09-01

    The Johns Hopkins University sounding rocket group is entering the final fabrication phase of the Far-ultraviolet Off Rowland-circle Telescope for Imaging and Spectroscopy (FORTIS); a sounding rocket borne multi-object spectro-telescope designed to provide spectral coverage of 43 separate targets in the 900 - 1800 Angstrom bandpass over a 30' x 30' field-of- view. Using "on-the-fly" target acquisition and spectral multiplexing enabled by a GSFC microshutter array, FORTIS will be capable of observing the brightest regions in the far-UV of nearby low redshift (z ~ 0.002 - 0.02) star forming galaxies to search for Lyman alpha escape, and to measure the local gas-to-dust ratio. A large area (~ 45 mm x 170 mm) microchannel plate detector built by Sensor Sciences provides an imaging channel for targeting flanked by two redundant spectral outrigger channels. The grating is ruled directly onto the secondary mirror to increase efficiency. In this paper, we discuss the recent progress made in the development and fabrication of FORTIS, as well as the results of early calibration and characterization of our hardware, including mirror/grating measurements, detector performance, and early operational tests of the microshutter arrays.

  4. High-Thermal-Conductivity Fabrics

    Science.gov (United States)

    Chibante, L. P. Felipe

    2012-01-01

    Heat management with common textiles such as nylon and spandex is hindered by the poor thermal conductivity from the skin surface to cooling surfaces. This innovation showed marked improvement in thermal conductivity of the individual fibers and tubing, as well as components assembled from them. The problem is centered on improving the heat removal of the liquid-cooled ventilation garments (LCVGs) used by astronauts. The current design uses an extensive network of water-cooling tubes that introduces bulkiness and discomfort, and increases fatigue. Range of motion and ease of movement are affected as well. The current technology is the same as developed during the Apollo program of the 1960s. Tubing material is hand-threaded through a spandex/nylon mesh layer, in a series of loops throughout the torso and limbs such that there is close, form-fitting contact with the user. Usually, there is a nylon liner layer to improve comfort. Circulating water is chilled by an external heat exchanger (sublimator). The purpose of this innovation is to produce new LCVG components with improved thermal conductivity. This was addressed using nanocomposite engineering incorporating high-thermalconductivity nanoscale fillers in the fabric and tubing components. Specifically, carbon nanotubes were added using normal processing methods such as thermoplastic melt mixing (compounding twin screw extruder) and downstream processing (fiber spinning, tubing extrusion). Fibers were produced as yarns and woven into fabric cloths. The application of isotropic nanofillers can be modeled using a modified Nielsen Model for conductive fillers in a matrix based on Einstein s viscosity model. This is a drop-in technology with no additional equipment needed. The loading is limited by the ability to maintain adequate dispersion. Undispersed materials will plug filtering screens in processing equipment. Generally, the viscosity increases were acceptable, and allowed the filled polymers to still be

  5. Fabric based supercapacitor

    International Nuclear Information System (INIS)

    Yong, S; Tudor, M J; Beeby, S P; Owen, J R

    2013-01-01

    Flexible supercapacitors with electrodes coated on inexpensive fabrics by the dipping technique. This paper present details of the design, fabrication and characterisation of fabric supercapacitor. The sandwich structured supercapacitors can achieve specific capacitances of 11.1F/g, area capacitance 105 mF.cm −2 and maintain 95% of the initial capacitance after cycling the device for more than 15000 times

  6. MAGNETIC WOVEN FABRICS - PHYSICAL AND MAGNETIC PROPERTIES

    Directory of Open Access Journals (Sweden)

    GROSU Marian C

    2015-05-01

    Full Text Available A coated material is a composite structure that consists of at least two components: base material and coating layer. The purpose of coating is to provide special properties to base material, with potential to be applied in EMI shielding and diverse smart technical fields. This paper reports the results of a study about some physical and magnetic properties of coated woven fabrics made from cotton yarns with fineness of 17 metric count. For this aim, a plain woven fabric was coated with a solution hard magnetic polymer based. As hard magnetic powder, barium hexaferrite (BaFe12O19 was selected. The plain woven fabric used as base has been coated with five solutions having different amounts of hard magnetic powder (15% - 45% in order to obtain five different magnetic woven fabrics. A comparison of physical properties regarding weight (g/m2, thickness (mm, degree of charging (% and magnetic properties of magnetic woven samples were presented. Saturation magnetizing (emu/g, residual magnetizing (emu/g and coercive force (kA/m of pure hard magnetic powder and woven fabrics have been studied as hysteresis characteristics. The magnetic properties of the woven fabrics depend on the mass percentage of magnetic powder from coating solution. Also, the residual magnetism and coercive field of woven fabrics represents only a part of bulk barium hexafferite residual magnetism and coercive field.

  7. The SMES model coil. Fabrication

    International Nuclear Information System (INIS)

    Hanai, Satoshi; Nakamoto, Kazunari; Takahashi, Nobuji

    1998-01-01

    A SMES model coil was fabricated as R and D item in the development of component technologies for a 480 MJ/20 MW SMES pilot plant. The coil consists of four double-pancake windings. The coil is the same diameter but half the number of pancakes that will be needed for a SMES pilot plant. The NbTi cable-in-conduit conductor and superconducting joints between the double pancakes are cooled by a forced flow of supercritical helium. Prior to fabrication, various characteristics of the cable-in-conduit were measured by full-sized short samples from actual conductors and by scaled short samples from scaled conductors. The critical current of the scaled short samples was in agreement with that calculated from one strand of the conductor. The impedance between arbitrary dual-oxide coated strands in the full-size conductor was measured to be smaller than that obtained from two Cr-plated strands, which showed a good degree of stability in another coil. It was estimated that oxide-coated conductors would have high stability. Through fabrication of a model coil, it was demonstrated that a large forced-flow coil for a small-scale 100 kWh SMES device could be manufactured. (author)

  8. The SMES model coil. Fabrication

    Energy Technology Data Exchange (ETDEWEB)

    Hanai, Satoshi; Nakamoto, Kazunari; Takahashi, Nobuji [Toshiba Corp., Yokohama, Kanagawa (Japan)] [and others

    1998-07-01

    A SMES model coil was fabricated as R and D item in the development of component technologies for a 480 MJ/20 MW SMES pilot plant. The coil consists of four double-pancake windings. The coil is the same diameter but half the number of pancakes that will be needed for a SMES pilot plant. The NbTi cable-in-conduit conductor and superconducting joints between the double pancakes are cooled by a forced flow of supercritical helium. Prior to fabrication, various characteristics of the cable-in-conduit were measured by full-sized short samples from actual conductors and by scaled short samples from scaled conductors. The critical current of the scaled short samples was in agreement with that calculated from one strand of the conductor. The impedance between arbitrary dual-oxide coated strands in the full-size conductor was measured to be smaller than that obtained from two Cr-plated strands, which showed a good degree of stability in another coil. It was estimated that oxide-coated conductors would have high stability. Through fabrication of a model coil, it was demonstrated that a large forced-flow coil for a small-scale 100 kWh SMES device could be manufactured. (author)

  9. Fabrics in Function

    DEFF Research Database (Denmark)

    Bang, Anne Louise

    2007-01-01

    sensing of fabrics in function. It is proposed that tactile and visual sensing of fabrics is a way to investigate and express emotional utility values. The further purpose is to use experiments with repertory grid models as part of the mapping of the entire research project and also as a basis...

  10. Fabricating architectural volume

    DEFF Research Database (Denmark)

    Feringa, Jelle; Søndergaard, Asbjørn

    2015-01-01

    The 2011 edition of Fabricate inspired a number of collaborations, this article seeks to highlight three of these. There is a common thread amongst the projects presented: sharing the ambition to close the rift between design and fabrication while incorporating structural design aspects early on...

  11. Smart Fabrics Technology Development

    Science.gov (United States)

    Simon, Cory; Potter, Elliott; Potter, Elliott; McCabe, Mary; Baggerman, Clint

    2010-01-01

    Advances in Smart Fabrics technology are enabling an exciting array of new applications for NASA exploration missions, the biomedical community, and consumer electronics. This report summarizes the findings of a brief investigation into the state of the art and potential applications of smart fabrics to address challenges in human spaceflight.

  12. Requirements for containment system components in CANDU nuclear power plants

    International Nuclear Information System (INIS)

    1988-02-01

    This Standard specifies the requirements and establishes the rules for design, fabrication, and installation of pressure-retaining containment system components. In this Standard the term 'components' includes non registered items

  13. Requirements for containment system components in CANDU nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1988-02-01

    This Standard specifies the requirements and establishes the rules for design, fabrication, and installation of pressure-retaining containment system components. In this Standard the term `components` includes non registered items.

  14. Fabrication of pressure vessels for nuclear power plants

    International Nuclear Information System (INIS)

    Sampaio, M.S.P. de

    1982-01-01

    The status of the technology used in the fabrication of pressure vessel for nuclear power plants and the performance of the Brazilian industry in this area are presented. The followng aspects are discussed: qualification of the industries for the supplying equipment in its requirement categories; the calculation of the components; the choice of the materials; the fabrication process; and, the destructive and nondestructive tests associated to the fabrication. (E.G.) [pt

  15. Optics fabrication technical challenges

    International Nuclear Information System (INIS)

    Chabassier, G.; Ferriou, N.; Lavastre, E.; Maunier, C.; Neauport, J.; Taroux, D.; Balla, D.; Fornerod, J.C.

    2004-01-01

    Before the production of all the LMJ (MEGAJOULE laser) optics, the CEA had to proceed with the fabrication of about 300 large optics for the LIL (laser integration line) laser. Thanks to a fruitful collaboration with high-tech optics companies in Europe, this challenge has been successfully hit. In order to achieve the very tight requirements for cleanliness, laser damage threshold and all the other high demanding fabrication specifications, it has been necessary to develop and to set completely new fabrication process going and to build special outsize fabrication equipment. Through a couple of examples, this paper gives an overview of the work which has been done and shows some of the results which have been obtained: continuous laser glass melting, fabrication of the laser slabs, rapid-growth KDP (potassium dihydrogen phosphate) technology, large diffractive transmission gratings engraving and characterization. (authors)

  16. Sintering furnace for remote fuel fabrication

    International Nuclear Information System (INIS)

    Bowen, W.W.

    1978-10-01

    Component testing and evaluation of a chemical vapor deposition Re/W muffle has been initiated. Hydrogen permeation testing and thermal cycling behavior will be evaluated. Fabrication of prototype 10-12 Kg furnace is scheduled for completion late in 1979, at which time testing of the system will be initiated

  17. Principal components

    NARCIS (Netherlands)

    Hallin, M.; Hörmann, S.; Piegorsch, W.; El Shaarawi, A.

    2012-01-01

    Principal Components are probably the best known and most widely used of all multivariate analysis techniques. The essential idea consists in performing a linear transformation of the observed k-dimensional variables in such a way that the new variables are vectors of k mutually orthogonal

  18. Fabrication of ceramic components for fluidics with green machining and reaction binding of Al-containing precursor mixes - component design and testing. Final report; Fertigung von keramischen Bauteilen fuer die Fluidtechnik mit Gruenbearbeitung und Reaktionsbinden von Al-haltigen Precursormischungen - Bauteilgestaltung und Erprobung. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Skirde, E.; Esders, H.; Ivantysyn, J.

    2003-03-05

    The Sauer-Danfoss project covered the testing of ceramic pistons and bushings in oil-hydraulic swash plate axial piston pumps. Both components move relative to each other while transmitting very high forces. This results in high component stresses and in high tribological loads of the contact surface. If the ceramic components can withstand both types of stress, the range of permissible operating parameters can be extended, especially the maximum speed as ceramics have a much lower specific mass than metals, which result in much lower inertial forces. In conventional systems of steel piston and metal bushing, high speed and high temperatures will result in poor lubrication and cause freezing of the piston. This is not the case with ceramics because of their great hardness, heat resistance, and chemical inertness. (orig.) [German] Das Teilprojekt von Sauer-Danfoss befasste sich mit der Erprobung keramischer Kolben und Buchsen in oelhydraulischen Schraegscheiben-Axialkolbenpumpen. Beide Bauteile (die sogenannten Leitteile) bewegen sich relativ zueinander und uebertragen dabei sehr hohe Betriebskraefte. Daraus resultieren nicht nur grosse Spannungen in den Teilen, sondern auch hohe tribologische Beanspruchungen in der Kontaktflaeche. Wenn die keramischen Bauteile beiden Beanspruchungsarten gewachsen sind, dann ist eine Ausdehnung des Bereichs erlaubter Betriebsparameter moeglich. Insbesondere ist hier die maximale Drehzahl zu nennen, da aus der im Vergleich zu metallischen Werkstoffen sehr geringen spezifischen Masse von Keramik weitaus geringere Traegheitskraefte resultieren. Bei der konventionellen Werkstoffpaarung (gehaerteter Stahlkolben-Messingbuchse) besteht ausserdem bei hohen Drehzahlen und Temperaturen wegen der damit verbundenen schlechten Schmierung die Gefahr des Festfressens. Diese ist bei keramischen Werkstoffen aufgrund der hohen Haerte, Waermebestaendigkeit und chemischen Inertheit nicht zu erwarten. (orig.)

  19. New polymorphous computing fabric

    International Nuclear Information System (INIS)

    Wolinski, Christophe; Gokhale, Maya; McCabe, Kevin P.

    2002-01-01

    This paper introduces a new polymorphous computing Fabric well suited to DSP and Image Processing and describes its implementation on a Configurable System on a Chip (CSOC). The architecture is highly parameterized and enables customization of the synthesized Fabric to achieve high performance for a specific class of application. For this reason it can be considered to be a generic model for hardware accelerator synthesis from a high level specification. Another important innovation is the Fabric uses a global memory concept, which gives the host processor random access to all the variables and instructions on the Fabric. The Fabric supports different computing models including MIMD, SPMD and systolic flow and permits dynamic reconfiguration. We present a specific implementation of a bank of FIR filters on a Fabric composed of 52 cells on the Altera Excalibur ARM running at 33 MHz. The theoretical performance of this Fabric is 1.8 GMACh. For the FIR application we obtain 1.6 GMAC/s real performance. Some automatic tools have been developed like the tool to provide a host access utility and assembler.

  20. Fabrication and characterisation of fabric supercapacitor

    OpenAIRE

    Yong, Sheng

    2016-01-01

    Fabric supercapacitor is a flexible electrochemical device for energy storage application. It is designed to power up flexible electronic systems used for, for example, information sensing, data computation and communication. The development of a flexible supercapacitor is important for e-textiles since supercapacitor can achieve higher energy density than a standard parallel plate capacitor and a larger power density compared with a battery. This research area is currently facing barriers on...

  1. Junction and circuit fabrication

    International Nuclear Information System (INIS)

    Jackel, L.D.

    1980-01-01

    Great strides have been made in Josephson junction fabrication in the four years since the first IC SQUID meeting. Advances in lithography have allowed the production of devices with planar dimensions as small as a few hundred angstroms. Improved technology has provided ultra-high sensitivity SQUIDS, high-efficiency low-noise mixers, and complex integrated circuits. This review highlights some of the new fabrication procedures. The review consists of three parts. Part 1 is a short summary of the requirements on junctions for various applications. Part 2 reviews intergrated circuit fabrication, including tunnel junction logic circuits made at IBM and Bell Labs, and microbridge radiation sources made at SUNY at Stony Brook. Part 3 describes new junction fabrication techniques, the major emphasis of this review. This part includes a discussion of small oxide-barrier tunnel junctions, semiconductor barrier junctions, and microbridge junctions. Part 3 concludes by considering very fine lithography and limitations to miniaturization. (orig.)

  2. Experimental Fabrication Facility

    Data.gov (United States)

    Federal Laboratory Consortium — Provides aviation fabrication support to special operations aircraft residing at Fort Eustis and other bases in the United States. Support is also provided to AATD...

  3. Alloy Fabrication Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — At NETL’s Alloy Fabrication Facility in Albany, OR, researchers conduct DOE research projects to produce new alloys suited to a variety of applications, from gas...

  4. Minor Actinide Laboratory at JRC-ITU: Fuel fabrication facility

    International Nuclear Information System (INIS)

    Fernandez, A.; McGinley, J.; Somers, J.

    2008-01-01

    The Minor Actinide Laboratory (MA-lab) of the Institute for Transuranium Elements is a unique facility for the fabrication of fuels and targets containing minor actinides (MA). It is of key importance for research on Partitioning and Transmutation in Europe, as it is one of the only dedicated facilities for the fabrication of MA containing materials, either for property measurements or for the production of test pins for irradiation experiments. In this paper a detailed description of the MA-Lab facility and the fabrication processes developed to fabricate fuels and samples containing high content of minor actinides is given. In addition, experience gained and improvements are also outlined. (authors)

  5. Manufacturing and testing in reactor relevant conditions of brazed plasma facing components of the ITER divertor

    International Nuclear Information System (INIS)

    Bisio, M.; Branca, V.; Marco, M. Di; Federici, A.; Grattarola, M.; Gualco, G.; Guarnone, P.; Luconi, U.; Merola, M.; Ozzano, C.; Pasquale, G.; Poggi, P.; Rizzo, S.; Varone, F.

    2005-01-01

    A fabrication route based on brazing technology has been developed for the realization of the high heat flux components for the ITER vertical target and Dome-Liner. The divertor vertical target is armoured with carbon fiber reinforced carbon and tungsten in the lower straight part and in the upper curved part, respectively. The armour material is joined to heat sinks made of precipitation hardened copper-chromium-zirconium alloy. The plasma facing units of the dome component are based on a tungsten flat tile design with hypervapotron cooling. An innovative brazing technique based on the addition of carbon fibers to the active brazing alloy, developed by Ansaldo Ricerche for applications in the field of the energy production, has been used for the carbon fiber composite to copper joint to reduce residual stresses. The tungsten-copper joint has been realized by direct casting. A proper brazing thermal cycle has been studied to guarantee the required mechanical properties of the precipitation hardened alloy after brazing. The fabrication route of plasma facing components for the ITER vertical target and dome based on the brazing technology has been proved by means of thermal fatigue tests performed on mock-ups in reactor relevant conditions

  6. Inertial-confinement-fusion targets

    International Nuclear Information System (INIS)

    Hendricks, C.D.

    1981-01-01

    Inertial confinement fusion (ICF) targets are made as simple flat discs, as hollow shells or as complicated multilayer structures. Many techniques have been devised for producing the targets. Glass and metal shells are made by using drop and bubble techniques. Solid hydrogen shells are also produced by adapting old methods to the solution of modern problems. Some of these techniques, problems and solutions are discussed. In addition, the applications of many of the techniques to fabrication of ICF targets is presented

  7. Deformation and Fabric in Compacted Clay Soils

    Science.gov (United States)

    Wensrich, C. M.; Pineda, J.; Luzin, V.; Suwal, L.; Kisi, E. H.; Allameh-Haery, H.

    2018-05-01

    Hydromechanical anisotropy of clay soils in response to deformation or deposition history is related to the micromechanics of platelike clay particles and their orientations. In this article, we examine the relationship between microstructure, deformation, and moisture content in kaolin clay using a technique based on neutron scattering. This technique allows for the direct characterization of microstructure within representative samples using traditional measures such as orientation density and soil fabric tensor. From this information, evidence for a simple relationship between components of the deviatoric strain tensor and the deviatoric fabric tensor emerge. This relationship may provide a physical basis for future anisotropic constitutive models based on the micromechanics of these materials.

  8. Sprayed skin turbine component

    Science.gov (United States)

    Allen, David B

    2013-06-04

    Fabricating a turbine component (50) by casting a core structure (30), forming an array of pits (24) in an outer surface (32) of the core structure, depositing a transient liquid phase (TLP) material (40) on the outer surface of the core structure, the TLP containing a melting-point depressant, depositing a skin (42) on the outer surface of the core structure over the TLP material, and heating the assembly, thus forming both a diffusion bond and a mechanical interlock between the skin and the core structure. The heating diffuses the melting-point depressant away from the interface. Subsurface cooling channels (35) may be formed by forming grooves (34) in the outer surface of the core structure, filling the grooves with a fugitive filler (36), depositing and bonding the skin (42), then removing the fugitive material.

  9. A triple axes multiple target holder assembly

    International Nuclear Information System (INIS)

    Tribedi, L.C.; Narvekar, S.D.; Pillay, R.G.; Tandon, P.N.

    1993-01-01

    We have designed and fabricated a rotatable target holder assembly capable of accommodating 27 targets. The target foils are mounted along two concentric circles on a ss wheel. On the outer circle 18 targets can be mounted each 20deg apart, and on the inner circle the remaining targets are positioned each 40deg apart. The self supporting or carbon backed targets are mounted on thin frames and are placed concentrically at the targets are mounted on thin frames and are placed concentrically at the target position on the wheel. Three degrees of freedom are provided to the target holder assembly. (author). 1 fig

  10. DESIGN AND FABRICATION OF MICRONOZZLES

    Directory of Open Access Journals (Sweden)

    Kean How Cheah

    2011-05-01

    Full Text Available Normal 0 false false false EN-US ZH-CN X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:SimSun; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} Micronozzle, a key component in micropropulsion system, has been designed and fabricated. Quasi 1D inviscid theory was used in designing a series of conical micronozzles of different expander half-angles (10°-50°. Aerospike micronozzle, a promising candidate to achieve high performance propulsion system, was designed with Angelino method (or Approximate method. Both micronozzles were fabricated using soft lithography, an inexpensive and relatively simple technique comparing to well-established deep reactive ion etching (DRIE technique, with polydimethylsiloxane (PDMS as structural material. Micronozzles with two different nozzle throat width, 53.5µm and 107µm, were fabricated for comparison. Microscopic inspections reveal 107µm is the more producible nozzle throat width with current equipments. The PDMS-based micronozzle can be used as cold gas microthruster system for micro- and nanosatellites.

  11. HIP technologies for fusion reactor blankets fabrication

    International Nuclear Information System (INIS)

    Le Marois, G.; Federzoni, L.; Bucci, P.; Revirand, P.

    2000-01-01

    The benefit of HIP techniques applied to the fabrication of fusion internal components for higher performances, reliability and cost savings are emphasized. To demonstrate the potential of the techniques, design of new blankets concepts and mock-ups fabrication are currently performed by CEA. A coiled tube concept that allows cooling arrangement flexibility, strong reduction of the machining and number of welds is proposed for ITER IAM. Medium size mock-ups according to the WCLL breeding blanket concept have been manufactured. The fabrication of a large size mock-up is under progress. These activities are supported by numerical calculations to predict the deformations of the parts during HIP'ing. Finally, several HIP techniques issues have been identified and are discussed

  12. Mechanical properties, chemical analysis and evaluation of antimicrobial response of Si-DLC coatings fabricated on AISI 316 LVM substrate by a multi-target DC-RF magnetron sputtering method for potential biomedical applications

    Science.gov (United States)

    Bociaga, Dorota; Sobczyk-Guzenda, Anna; Szymanski, Witold; Jedrzejczak, Anna; Jastrzebska, Aleksandra; Olejnik, Anna; Jastrzebski, Krzysztof

    2017-09-01

    In this study silicon doped diamond-like carbon (Si-DLC) coatings were synthesized on two substrates: silicon and AISI 316LVM stainless steel using a multi-target DC-RF magnetron sputtering method. The Si content in the films ranged between 4 and 16 at.%, and was controlled by the electrical power applied in RF regime to Si cathode target. The character of the chemical bonds was revealed by FTIR analysis. With the addition of silicon the hydroxyl absorption (band in the range of 3200-3600 cm-1) increased what suggests more hydrophilic character of the coating. There were also observed significant changes in bonding of Si atoms. For low content of dopant, Si-O-Si bond system is predominant, while for the highest content of silicon there is an evidence of the shift to Si-C bonds in close proximity to methyl groups. The Raman spectroscopy revealed that the G peak position is shifted to a lower wavenumber and the ID/IG ratio decreased with increasing Si content, which indicates an increase in the C-sp3 content. Regardless of the coatings' composition, the improvement of hardness in comparison to pure substrate material (AISI 316 LVM) was observed. Although the reduction of the level of hardness from the level of 10.8 GPa for pure DLC to about 9.4 GPa for the silicon doped coatings was observed, the concomitant improvement of films adhesion with higher amount of Si was revealed. Although incorporation of the dopant to DLC coatings increases the number of E. coli cells which adhered to the examined surfaces, the microbial colonisation remains on the level of substrate material. The presented results prove the potential of Si-DLC coatings in biomedical applications from the point of view of their mechanical properties.

  13. One-step fabrication of multifunctional micromotors

    Science.gov (United States)

    Gao, Wenlong; Liu, Mei; Liu, Limei; Zhang, Hui; Dong, Bin; Li, Christopher Y.

    2015-08-01

    Although artificial micromotors have undergone tremendous progress in recent years, their fabrication normally requires complex steps or expensive equipment. In this paper, we report a facile one-step method based on an emulsion solvent evaporation process to fabricate multifunctional micromotors. By simultaneously incorporating various components into an oil-in-water droplet, upon emulsification and solidification, a sphere-shaped, asymmetric, and multifunctional micromotor is formed. Some of the attractive functions of this model micromotor include autonomous movement in high ionic strength solution, remote control, enzymatic disassembly and sustained release. This one-step, versatile fabrication method can be easily scaled up and therefore may have great potential in mass production of multifunctional micromotors for a wide range of practical applications.Although artificial micromotors have undergone tremendous progress in recent years, their fabrication normally requires complex steps or expensive equipment. In this paper, we report a facile one-step method based on an emulsion solvent evaporation process to fabricate multifunctional micromotors. By simultaneously incorporating various components into an oil-in-water droplet, upon emulsification and solidification, a sphere-shaped, asymmetric, and multifunctional micromotor is formed. Some of the attractive functions of this model micromotor include autonomous movement in high ionic strength solution, remote control, enzymatic disassembly and sustained release. This one-step, versatile fabrication method can be easily scaled up and therefore may have great potential in mass production of multifunctional micromotors for a wide range of practical applications. Electronic supplementary information (ESI) available: Videos S1-S4 and Fig. S1-S3. See DOI: 10.1039/c5nr03574k

  14. ATLAS facility fabrication and assembly

    CERN Document Server

    Ballard, E O; Davis, H A; Nielsen, K E; Parker, G V; Parsons, W M

    2001-01-01

    Summary form only given. Atlas is a pulsed-power facility recently completed at Los Alamos National Laboratory to drive hydrodynamic experiments. This new generation pulsed-power machine consists of a radial array of 24, 240-kV Marx modules and transmission lines supplying current to the load region at the machine center. The transmission lines, powered by the Marx modules, consist of cable headers, load protection switches and tri-plates interfacing to the center transition section through detachable current joints. A conical power-flow-channel attaches to the transition section providing an elevated interface to attach the experimental loads for diagnostic access. Fabrication and assembly of all components for the Atlas machine was completed in August 2000. The machine has also progressed through a test phase where the Marx module/transmission line units were fired, individually, into a test load. Progression continued with eight and sixteen lines being fired. Subsequently, an overall machine test was condu...

  15. Understanding core conductor fabrics

    International Nuclear Information System (INIS)

    Swenson, D E

    2011-01-01

    ESD Association standard test method ANSI/ESD STM2.1 - Garments (STM2.1), provides electrical resistance test procedures that are applicable for materials and garments that have surface conductive or surface dissipative properties. As has been reported in other papers over the past several years 1 fabrics are now used in many industries for electrostatic control purposes that do not have surface conductive properties and therefore cannot be evaluated using the procedures in STM2.1 2 . A study was conducted to compare surface conductive fabrics with samples of core conductor fibre based fabrics in order to determine differences and similarities with regards to various electrostatic properties. This work will be used to establish a new work item proposal within WG-2, Garments, in the ESD Association Standards Committee in the USA.

  16. Deep Proton Writing for the rapid prototyping of polymer micro-components for optical interconnects and optofluidics

    Science.gov (United States)

    Van Erps, Jürgen; Vervaeke, Michael; Ottevaere, Heidi; Hermanne, Alex; Thienpont, Hugo

    2013-07-01

    The use of photonics in data communication and numerous other industrial applications brought plenty of prospects for innovation and opened up different unexplored market opportunities. This is a major driving force for the fabrication of micro-optical and micro-mechanical structures and their accurate alignment and integration into opto-mechanical modules and systems. To this end, we present Deep Proton Writing (DPW) as a powerful rapid prototyping technology for such micro-components. The DPW process consists of bombarding polymer samples (PMMA or SU-8) with swift protons, which results after chemical processing steps in high-quality micro-optical components. One of the strengths of the DPW micro-fabrication technology is the ability to fabricate monolithic building blocks that include micro-optical and mechanical functionalities which can be precisely integrated into more complex photonic systems. In this paper we comment on how we shifted from using 8.3 to 16.5 MeV protons for DPW and give some examples of micro-optical and micro-mechanical components recently fabricated through DPW, targeting applications in optical interconnections and in optofluidics.

  17. Deep Proton Writing for the rapid prototyping of polymer micro-components for optical interconnects and optofluidics

    Energy Technology Data Exchange (ETDEWEB)

    Van Erps, Jürgen, E-mail: jurgen.van.erps@vub.ac.be; Vervaeke, Michael; Ottevaere, Heidi; Hermanne, Alex; Thienpont, Hugo

    2013-07-15

    The use of photonics in data communication and numerous other industrial applications brought plenty of prospects for innovation and opened up different unexplored market opportunities. This is a major driving force for the fabrication of micro-optical and micro-mechanical structures and their accurate alignment and integration into opto-mechanical modules and systems. To this end, we present Deep Proton Writing (DPW) as a powerful rapid prototyping technology for such micro-components. The DPW process consists of bombarding polymer samples (PMMA or SU-8) with swift protons, which results after chemical processing steps in high-quality micro-optical components. One of the strengths of the DPW micro-fabrication technology is the ability to fabricate monolithic building blocks that include micro-optical and mechanical functionalities which can be precisely integrated into more complex photonic systems. In this paper we comment on how we shifted from using 8.3 to 16.5 MeV protons for DPW and give some examples of micro-optical and micro-mechanical components recently fabricated through DPW, targeting applications in optical interconnections and in optofluidics.

  18. Fabrication of multilayer nanowires

    Energy Technology Data Exchange (ETDEWEB)

    Kaur, Jasveer, E-mail: kaurjasveer89@gmail.com; Singh, Avtar; Kumar, Davinder [Department of Physics, Punjabi University Patiala, 147002, Punjab (India); Thakur, Anup; Kaur, Raminder, E-mail: raminder-k-saini@yahoo.com [Department of Basic and Applied Sciences, Punjabi University Patiala, 147002, Punjab (India)

    2016-05-06

    Multilayer nanowires were fabricated by potentiostate ectrodeposition template synthesis method into the pores of polycarbonate membrane. In present work layer by layer deposition of two different metals Ni and Cu in polycarbonate membrane having pore size of 600 nm were carried out. It is found that the growth of nanowires is not constant, it varies with deposition time. Scanning electron microscopy (SEM) is used to study the morphology of fabricated multilayer nanowires. An energy dispersive X-ray spectroscopy (EDS) results confirm the composition of multilayer nanowires. The result shows that multilayer nanowires formed is dense.

  19. MOX Fabrication Isolation Considerations

    Energy Technology Data Exchange (ETDEWEB)

    Eric L. Shaber; Bradley J Schrader

    2005-08-01

    This document provides a technical position on the preferred level of isolation to fabricate demonstration quantities of mixed oxide transmutation fuels. The Advanced Fuel Cycle Initiative should design and construct automated glovebox fabrication lines for this purpose. This level of isolation adequately protects the health and safety of workers and the general public for all mixed oxide (and other transmutation fuel) manufacturing efforts while retaining flexibility, allowing parallel development and setup, and minimizing capital expense. The basis regulations, issues, and advantages/disadvantages of five potential forms of isolation are summarized here as justification for selection of the preferred technical position.

  20. Fabrication of multilayer nanowires

    International Nuclear Information System (INIS)

    Kaur, Jasveer; Singh, Avtar; Kumar, Davinder; Thakur, Anup; Kaur, Raminder

    2016-01-01

    Multilayer nanowires were fabricated by potentiostate ectrodeposition template synthesis method into the pores of polycarbonate membrane. In present work layer by layer deposition of two different metals Ni and Cu in polycarbonate membrane having pore size of 600 nm were carried out. It is found that the growth of nanowires is not constant, it varies with deposition time. Scanning electron microscopy (SEM) is used to study the morphology of fabricated multilayer nanowires. An energy dispersive X-ray spectroscopy (EDS) results confirm the composition of multilayer nanowires. The result shows that multilayer nanowires formed is dense.

  1. Methods for fabrication of flexible hybrid electronics

    Science.gov (United States)

    Street, Robert A.; Mei, Ping; Krusor, Brent; Ready, Steve E.; Zhang, Yong; Schwartz, David E.; Pierre, Adrien; Doris, Sean E.; Russo, Beverly; Kor, Siv; Veres, Janos

    2017-08-01

    Printed and flexible hybrid electronics is an emerging technology with potential applications in smart labels, wearable electronics, soft robotics, and prosthetics. Printed solution-based materials are compatible with plastic film substrates that are flexible, soft, and stretchable, thus enabling conformal integration with non-planar objects. In addition, manufacturing by printing is scalable to large areas and is amenable to low-cost sheet-fed and roll-to-roll processes. FHE includes display and sensory components to interface with users and environments. On the system level, devices also require electronic circuits for power, memory, signal conditioning, and communications. Those electronic components can be integrated onto a flexible substrate by either assembly or printing. PARC has developed systems and processes for realizing both approaches. This talk presents fabrication methods with an emphasis on techniques recently developed for the assembly of off-the-shelf chips. A few examples of systems fabricated with this approach are also described.

  2. Feasibility Study of Laser Cutting for Fabrication of Tensile Specimen

    International Nuclear Information System (INIS)

    Jin, Y. G.; Baik, S. J.; Kim, G. S.; Heo, G. S.; Yoo, B. O.; Ahn, S. B.; Chun, Y. B.

    2015-01-01

    The specimen fabrication technique was established to machine the specimen from the irradiated materials. The wire cut EDM(electric discharge machine) was modified to fabricate the mechanical testing specimens from irradiated components and fuel claddings. The oxide layer removal system was also developed because the oxide layer on the surface of the irradiated components and claddings interrupted the applying the electric current during the processing. However, zirconium oxide is protective against further corrosion as well as beneficial to mechanical strength for the tensile deformation of the cladding. Thus, it is important to fabricate the irradiated specimens without removal of oxide layer on the surface of the irradiated structural components and claddings. In the present study, laser cutting system was introduced to fabricate the various mechanical testing specimens from the unirradiated fuel cladding and the feasibility of the laser cutting system was studied for the fabrication of various types of irradiated specimens in a hot cell at IMEF (Irradiated Materials Examination Facility) of KAERI. Laser beam machining system was introduced to fabricate the various mechanical testing specimens from the unirradiated fuel cladding and the dimensions were compared for the feasibility of the laser cutting system. The effect of surface oxide layer was also investigated for machining process of the zircaloy-4 fuel cladding and it was found that laser beam machining could be a useful tool to fabricate the specimens with surface oxide layer

  3. Feasibility Study of Laser Cutting for Fabrication of Tensile Specimen

    Energy Technology Data Exchange (ETDEWEB)

    Jin, Y. G.; Baik, S. J.; Kim, G. S.; Heo, G. S.; Yoo, B. O.; Ahn, S. B.; Chun, Y. B. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-05-15

    The specimen fabrication technique was established to machine the specimen from the irradiated materials. The wire cut EDM(electric discharge machine) was modified to fabricate the mechanical testing specimens from irradiated components and fuel claddings. The oxide layer removal system was also developed because the oxide layer on the surface of the irradiated components and claddings interrupted the applying the electric current during the processing. However, zirconium oxide is protective against further corrosion as well as beneficial to mechanical strength for the tensile deformation of the cladding. Thus, it is important to fabricate the irradiated specimens without removal of oxide layer on the surface of the irradiated structural components and claddings. In the present study, laser cutting system was introduced to fabricate the various mechanical testing specimens from the unirradiated fuel cladding and the feasibility of the laser cutting system was studied for the fabrication of various types of irradiated specimens in a hot cell at IMEF (Irradiated Materials Examination Facility) of KAERI. Laser beam machining system was introduced to fabricate the various mechanical testing specimens from the unirradiated fuel cladding and the dimensions were compared for the feasibility of the laser cutting system. The effect of surface oxide layer was also investigated for machining process of the zircaloy-4 fuel cladding and it was found that laser beam machining could be a useful tool to fabricate the specimens with surface oxide layer.

  4. Text-Fabric

    NARCIS (Netherlands)

    Roorda, Dirk

    2016-01-01

    Text-Fabric is a Python3 package for Text plus Annotations. It provides a data model, a text file format, and a binary format for (ancient) text plus (linguistic) annotations. The emphasis of this all is on: data processing; sharing data; and contributing modules. A defining characteristic is that

  5. PIGMI mechanical fabrication

    International Nuclear Information System (INIS)

    Hart, V.E.

    1976-01-01

    A prime goal of the mechanical design effort associated with the PIGMI (Pion Generator for Medical Irradiations) program is to investigate new materials and fabrication techniques in an effort to obtain increased machine efficiency and reliability at a reasonable cost. The following discussion deals with the modeling program that LASL is pursuing for 450-MHz and 1350-MHz PIGMI development. (author)

  6. Micromechanical Structures Fabrication; FINAL

    International Nuclear Information System (INIS)

    Rajic, S

    2001-01-01

    Work in materials other than silicon for MEMS applications has typically been restricted to metals and metal oxides instead of more ''exotic'' semiconductors. However, group III-V and II-VI semiconductors form a very important and versatile collection of material and electronic parameters available to the MEMS and MOEMS designer. With these materials, not only are the traditional mechanical material variables (thermal conductivity, thermal expansion, Young's modulus, etc.) available, but also chemical constituents can be varied in ternary and quaternary materials. This flexibility can be extremely important for both friction and chemical compatibility issues for MEMS. In addition, the ability to continually vary the bandgap energy can be particularly useful for many electronics and infrared detection applications. However, there are two major obstacles associated with alternate semiconductor material MEMS. The first issue is the actual fabrication of non-silicon micro-devices and the second impediment is communicating with these novel devices. We have implemented an essentially material independent fabrication method that is amenable to most group III-V and II-VI semiconductors. This technique uses a combination of non-traditional direct write precision fabrication processes such as diamond turning, ion milling, laser ablation, etc. This type of deterministic fabrication approach lends itself to an almost trivial assembly process. We also implemented a mechanical, electrical, and optical self-aligning hybridization technique for these alternate-material MEMS substrates

  7. Fabrication activity for nanophotonics

    DEFF Research Database (Denmark)

    Malureanu, Radu; Chung, Il-Sug; Carletti, Luca

    We present the fabrication and characterization of new structures and materials to be used in nanophotonics. The first structure presented is a fractal metallic metasurface designed to be used as a high-sensitivity sensor for 810nm wavelength. A second structure is a high index contrast grating...

  8. Rapid fabrication of flight worthy composite parts

    Science.gov (United States)

    Jouin, Pierre H.; Heigl, John C.; Youtsey, Timothy L.

    A 3D surfaced-model representation of aircraft composite structural components can be used to generate machining paths in a system which reduces paperwork and errors, and enhances accuracy and speed. Illustrative cases are presented for the use of such a system in the design and production of the Longbow radar housing, the fabrication of the flight test hardware for the 'no tail-rotor' helicopter control system, and the machining of a honeycomb core structure for a composite helicopter rotor blade.

  9. Targeting the tumor microenvironment

    Energy Technology Data Exchange (ETDEWEB)

    Kenny, P.A.; Lee, G.Y.; Bissell, M.J.

    2006-11-07

    Despite some notable successes cancer remains, for the most part, a seemingly intractable problem. There is, however, a growing appreciation that targeting the tumor epithelium in isolation is not sufficient as there is an intricate mutually sustaining synergy between the tumor epithelial cells and their surrounding stroma. As the details of this dialogue emerge, new therapeutic targets have been proposed. The FDA has already approved drugs targeting microenvironmental components such as VEGF and aromatase and many more agents are in the pipeline. In this article, we describe some of the 'druggable' targets and processes within the tumor microenvironment and review the approaches being taken to disrupt these interactions.

  10. Materials and fabrication requirements for APWR systems

    International Nuclear Information System (INIS)

    Boothby, R.M.; Hippsley, C.A.; Gorton, O.K.; Garwood, S.J.

    1995-01-01

    Materials specifications for advanced pressurized water-cooled reactor (APWR) systems are generally based on existing designs, with improved materials and fabrication procedures being developed to counter known degradation effects. In this paper, materials ageing and degradation mechanisms in PWR primary circuit pressure boundary components (i.e. the reactor pressure vessel (RPV), control rod drive mechanisms (CRDMs), coolant piping, coolant pump casing, pressurizer, and steam generators) are reviewed. Important degradation mechanisms include irradiation embrittlement of the RPV, thermal ageing embrittlement of ferritic (e.g. the pressurizer) and cast austenitic (e.g. coolant pump casing and pipe elbows) steel components and environmentally assisted cracking of steam generator tubing and CRDM penetrations. Improved materials specifications and component design and fabrication issues affecting the integrity of the pressure boundary are discussed in the light of these materials problems. Improved fabrication procedures adopted for Sizewell B, such as the utilization of ring forgings to eliminate axial welds in the RPV and steam generator shells and the use of one-piece castings for coolant pump casings, provide a benchmark against which other APWR designs may be judged. (author)

  11. Fabrication of inert matrices for heterogeneous transmutation. EFTTRA-T2 (RAS 2) irradiation programme

    International Nuclear Information System (INIS)

    Boshoven, J.G.; Hein, H.; Konings, R.J.M.

    1996-07-01

    This report describes the fabrication of targets containing inert matrices for the heterogeneous transmutation of plutonium and minor actinides. These targets will be irradiated in the EFTTRA-T2 (RAS-2) irradiation programme. The selection, preparation and characterization of the inert matrices and fabrication and loading of the irradiation capsules are discussed. (orig.)

  12. 2k micro moulding for MID fabrication

    DEFF Research Database (Denmark)

    Islam, Aminul; Hansen, Hans Nørgaard; Jørgensen, Martin Bondo

    2009-01-01

    Molded Interconnect Devices (MIDs) are plastic substrates with electrical infrastructure. The fabrication of MIDs is usually based on injection molding and different process chains may be identified from this starting point. The use of MIDs has been driven primarily by the automotive sector......, but recently the medical sector seems more and more interested. In particular, the possibility of miniaturization of 3D components with electrical infrastructure is attractive. The paper describes possible manufacturing routes and challenges of miniaturized MIDs based on two component injection molding...

  13. Foodservice yield and fabrication times for beef as influenced by purchasing options and merchandising styles.

    Science.gov (United States)

    Weatherly, B H; Griffin, D B; Johnson, H K; Walter, J P; De La Zerda, M J; Tipton, N C; Savell, J W

    2001-12-01

    Selected beef subprimals were obtained from fabrication lines of three foodservice purveyors to assist in the development of a software support program for the beef foodservice industry. Subprimals were fabricated into bone-in or boneless foodservice ready-to-cook portion-sized cuts and associated components by professional meat cutters. Each subprimal was cut to generate mean foodservice cutting yields and labor requirements, which were calculated from observed weights (kilograms) and processing times (seconds). Once fabrication was completed, data were analyzed to determine means and standard errors of percentage yields and processing times for each subprimal. Subprimals cut to only one end point were evaluated for mean foodservice yields and processing times, but no comparisons were made within subprimal. However, those traditionally cut into various end points were additionally compared by cutting style. Subprimals cut by a single cutting style included rib, roast-ready; ribeye roll, lip-on, bone-in; brisket, deckle-off, boneless; top (inside) round; and bottom sirloin butt, flap, boneless. Subprimals cut into multiple end points or styles included ribeye, lip-on; top sirloin, cap; tenderloin butt, defatted; shortloin, short-cut; strip loin, boneless; top sirloin butt, boneless; and tenderloin, full, side muscle on, defatted. Mean yields of portion cuts, and mean fabrication times required to manufacture these cuts differed (P < 0.05) by cutting specification of the final product. In general, as the target portion size of fabricated steaks decreased, the mean number of steaks derived from any given subprimal cut increased, causing total foodservice yield to decrease and total processing time to increase. Therefore, an inverse relationship tended to exist between processing times and foodservice yields. With a method of accurately evaluating various beef purchase options, such as traditional commodity subprimals, closely trimmed subprimals, and pre-cut portion

  14. Fabrication and operational experience with the interim storage cask

    International Nuclear Information System (INIS)

    Scott, P.L.

    1998-01-01

    This paper discusses the fabrication and operational experience of the Interim Storage Cask (ISC). The ISC is a dry storage cask which is used to safely store a Core Component Container (CCC) containing up to seven Fast Flux Test Facility (FFTF) spent fuel assemblies at the US Department of Energy's Hanford Site. Under contract to B and W Hanford Company (BWHC), General Atomics (GA) designed and fabricated thirty ISC casks which BWHC is remotely loading at the FFTF facility. BWHC designed and fabricated the CCCS. As of December 1997, thirty ISCs have been fabricated, of which eighteen have been loaded and moved to a storage site adjacent to the FFTF facility. Fabrication consisted of three sets of casks. The first unit was completed and acceptance tested before any other units were fabricated. After the first unit passed all acceptance tests, nine more units were fabricated in the first production run. Before those nine units were completed, GA began a production run of twenty more units. The paper provides an overview of the cask design and discusses the problems encountered in fabrication, their resolution, and changes made in the fabrication processes to improve the quality of the casks. The paper also discusses the loading process and operational experiences with loading and handling of the casks. Information on loading times, worker dose exposure, and total dose for loading are presented

  15. Alkali semi-metal films and method and apparatus for fabricating them

    Energy Technology Data Exchange (ETDEWEB)

    Bhandari, Harish B.; Nagarkar, Vivek V.; Ovechkina, Olena E.; Frisch, Henry J.; Attenkofer, Klaus; Smedley, John M.

    2018-03-13

    Methods and systems for fabricating a film, such as, for example, a photocathode, having a tailored band structure and thin-film components that can be tailored for specific applications, such as, for example photocathode having a high quantum efficiency, and simple components fabricated by those methods.

  16. Statistics of Shared Components in Complex Component Systems

    Science.gov (United States)

    Mazzolini, Andrea; Gherardi, Marco; Caselle, Michele; Cosentino Lagomarsino, Marco; Osella, Matteo

    2018-04-01

    Many complex systems are modular. Such systems can be represented as "component systems," i.e., sets of elementary components, such as LEGO bricks in LEGO sets. The bricks found in a LEGO set reflect a target architecture, which can be built following a set-specific list of instructions. In other component systems, instead, the underlying functional design and constraints are not obvious a priori, and their detection is often a challenge of both scientific and practical importance, requiring a clear understanding of component statistics. Importantly, some quantitative invariants appear to be common to many component systems, most notably a common broad distribution of component abundances, which often resembles the well-known Zipf's law. Such "laws" affect in a general and nontrivial way the component statistics, potentially hindering the identification of system-specific functional constraints or generative processes. Here, we specifically focus on the statistics of shared components, i.e., the distribution of the number of components shared by different system realizations, such as the common bricks found in different LEGO sets. To account for the effects of component heterogeneity, we consider a simple null model, which builds system realizations by random draws from a universe of possible components. Under general assumptions on abundance heterogeneity, we provide analytical estimates of component occurrence, which quantify exhaustively the statistics of shared components. Surprisingly, this simple null model can positively explain important features of empirical component-occurrence distributions obtained from large-scale data on bacterial genomes, LEGO sets, and book chapters. Specific architectural features and functional constraints can be detected from occurrence patterns as deviations from these null predictions, as we show for the illustrative case of the "core" genome in bacteria.

  17. Statistics of Shared Components in Complex Component Systems

    Directory of Open Access Journals (Sweden)

    Andrea Mazzolini

    2018-04-01

    Full Text Available Many complex systems are modular. Such systems can be represented as “component systems,” i.e., sets of elementary components, such as LEGO bricks in LEGO sets. The bricks found in a LEGO set reflect a target architecture, which can be built following a set-specific list of instructions. In other component systems, instead, the underlying functional design and constraints are not obvious a priori, and their detection is often a challenge of both scientific and practical importance, requiring a clear understanding of component statistics. Importantly, some quantitative invariants appear to be common to many component systems, most notably a common broad distribution of component abundances, which often resembles the well-known Zipf’s law. Such “laws” affect in a general and nontrivial way the component statistics, potentially hindering the identification of system-specific functional constraints or generative processes. Here, we specifically focus on the statistics of shared components, i.e., the distribution of the number of components shared by different system realizations, such as the common bricks found in different LEGO sets. To account for the effects of component heterogeneity, we consider a simple null model, which builds system realizations by random draws from a universe of possible components. Under general assumptions on abundance heterogeneity, we provide analytical estimates of component occurrence, which quantify exhaustively the statistics of shared components. Surprisingly, this simple null model can positively explain important features of empirical component-occurrence distributions obtained from large-scale data on bacterial genomes, LEGO sets, and book chapters. Specific architectural features and functional constraints can be detected from occurrence patterns as deviations from these null predictions, as we show for the illustrative case of the “core” genome in bacteria.

  18. Automated breeder fuel fabrication

    International Nuclear Information System (INIS)

    Goldmann, L.H.; Frederickson, J.R.

    1983-01-01

    The objective of the Secure Automated Fabrication (SAF) Project is to develop remotely operated equipment for the processing and manufacturing of breeder reactor fuel pins. The SAF line will be installed in the Fuels and Materials Examination Facility (FMEF). The FMEF is presently under construction at the Department of Energy's (DOE) Hanford site near Richland, Washington, and is operated by the Westinghouse Hanford Company (WHC). The fabrication and support systems of the SAF line are designed for computer-controlled operation from a centralized control room. Remote and automated fuel fabriction operations will result in: reduced radiation exposure to workers; enhanced safeguards; improved product quality; near real-time accountability, and increased productivity. The present schedule calls for installation of SAF line equipment in the FMEF beginning in 1984, with qualifying runs starting in 1986 and production commencing in 1987. 5 figures

  19. OPO fabric decontamination

    International Nuclear Information System (INIS)

    Severa, J.; Bar, J.; Grujbar, V.

    1978-01-01

    Samples of five polypropylene-based man-made fabrics were studied with regard to the degree of contamination and possibilities of decontamination in order to assess their suitability as material for protective clothing in the nuclear industry. The contamination degree of the fabrics in an aqueous solution of a fission product mixture was found to be low. Soaking in a mixture of the Sapon detergent and sodium hexametaphosphate at a concentration of both materials of 1 g/l with subsequent washing in a solution of the Zenit detergent at a concentration of 3 g/l was suggested as the most suitable decontamination procedure. It reduces the initial contamination by almost 99%. (Z.M.)

  20. CERN: Fixed target targets

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1993-03-15

    Full text: While the immediate priority of CERN's research programme is to exploit to the full the world's largest accelerator, the LEP electron-positron collider and its concomitant LEP200 energy upgrade (January, page 1), CERN is also mindful of its long tradition of diversified research. Away from LEP and preparations for the LHC proton-proton collider to be built above LEP in the same 27-kilometre tunnel, CERN is also preparing for a new generation of heavy ion experiments using a new source, providing heavier ions (April 1992, page 8), with first physics expected next year. CERN's smallest accelerator, the LEAR Low Energy Antiproton Ring continues to cover a wide range of research topics, and saw a record number of hours of operation in 1992. The new ISOLDE on-line isotope separator was inaugurated last year (July, page 5) and physics is already underway. The remaining effort concentrates around fixed target experiments at the SPS synchrotron, which formed the main thrust of CERN's research during the late 1970s. With the SPS and LEAR now approaching middle age, their research future was extensively studied last year. Broadly, a vigorous SPS programme looks assured until at least the end of 1995. Decisions for the longer term future of the West Experimental Area of the SPS will have to take into account the heavy demand for test beams from work towards experiments at big colliders, both at CERN and elsewhere. The North Experimental Area is the scene of larger experiments with longer lead times. Several more years of LEAR exploitation are already in the pipeline, but for the longer term, the ambitious Superlear project for a superconducting ring (January 1992, page 7) did not catch on. Neutrino physics has a long tradition at CERN, and this continues with the preparations for two major projects, the Chorus and Nomad experiments (November 1991, page 7), to start next year in the West Area. Delicate neutrino oscillation effects could become visible for the first

  1. A Wear Geometry Model of Plain Woven Fabric Composites

    Directory of Open Access Journals (Sweden)

    Gu Dapeng

    2014-09-01

    Full Text Available The paper g describes a model meant for analysis of the wear geometry of plain woven fabric composites. The referred model consists of a mathematical description of plain woven fabric based on Peirce’s model coupled with a stratified method for the solution of the wear geometry. The evolutions of the wear area ratio of weft yarn, warp yarn and matrix resin on the worn surface are simulated by MatLab software in combination of warp and weft yarn diameters, warp and weft yarn-to-yarn distances, fabric structure phases (SPs. By comparing theoretical and experimental results from the PTFE/Kevlar fabric wear experiment, it can be concluded that the model can present a trend of the component area ratio variations along with the thickness of fabric, but has a inherently large error in quantitative analysis as an idealized model.

  2. Fabrication and Testing of Deflecting Cavities for APS

    Energy Technology Data Exchange (ETDEWEB)

    Mammosser, John; Wang, Haipeng; Rimmer, Robert; Jim, Henry; Katherine, Wilson; Dhakal, Pashupati; Ali, Nassiri; Jim, Kerby; Jeremiah, Holzbauer; Genfa, Wu; Joel, Fuerst; Yawei, Yang; Zenghai, Li

    2013-09-01

    Jefferson Lab (Newport News, Virginia) in collaboration with Argonne National Laboratory (Argonne, IL) has fabricated and tested four first article, 2.8 GHz, deflecting SRF cavities, for Argonne's Short-Pulse X-ray (SPX) project. These cavities are unique in many ways including the fabrication techniques in which the cavity cell and waveguides were fabricated. These cavity subcomponents were milled from bulk large grain niobium ingot material directly from 3D CAD files. No forming of sub components was used with the exception of the beam-pipes. The challenging cavity and helium vessel design and fabrication results from the stringent RF performance requirements required by the project and operation in the APS ring. Production challenges and fabrication techniques as well as testing results will be discussed in this paper.

  3. Intentionally fabricated autobiographical memories

    OpenAIRE

    Justice, LV; Morrison, CM; Conway, MA

    2017-01-01

    Participants generated both autobiographical memories (AMs) that they believed to be true and intentionally fabricated autobiographical memories (IFAMs). Memories were constructed while a concurrent memory load (random 8-digit sequence) was held in mind or while there was no concurrent load. Amount and accuracy of recall of the concurrent memory load was reliably poorer following generation of IFAMs than following generation of AMs. There was no reliable effect of load on memory generation ti...

  4. Colored fused filament fabrication

    OpenAIRE

    Song, Haichuan; Lefebvre, Sylvain

    2017-01-01

    Filament fused fabrication is the method of choice for printing 3D models at low cost, and is the de-facto standard for hobbyists, makers and schools. Unfortunately, filament printers cannot truly reproduce colored objects. The best current techniques rely on a form of dithering exploiting occlusion, that was only demonstrated for shades of two base colors and that behaves differently depending on surface slope. We explore a novel approach for 3D printing colored objects, capable of creating ...

  5. Design and Fabrication of DebriSat - A Representative LEO Satellite for Improvements to Standard Satellite Breakup Models

    Science.gov (United States)

    Clark, S.; Dietrich, A.; Fitz-Coy, N.; Weremeyer, M.; Liou, J.-C.

    2012-01-01

    This paper discusses the design and fabrication of DebriSat, a 50 kg satellite developed to be representative of a modern low Earth orbit satellite in terms of its components, materials used, and fabrication procedures. DebriSat will be the target of a future hypervelocity impact experiment to determine the physical characteristics of debris generated after an on-orbit collision of a modern LEO satellite. The major ground-based satellite impact experiment used by DoD and NASA in their development of satellite breakup models was SOCIT, conducted in 1992. The target used for that experiment was a Navy transit satellite (40 cm, 35 kg) fabricated in the 1960's. Modern satellites are very different in materials and construction techniques than those built 40 years ago. Therefore, there is a need to conduct a similar experiment using a modern target satellite to improve the fidelity of the satellite breakup models. To ensure that DebriSat is truly representative of typical LEO missions, a comprehensive study of historical LEO satellite designs and missions within the past 15 years for satellites ranging from 1 kg to 5000 kg was conducted. This study identified modern trends in hardware, material, and construction practices utilized in recent LEO missions. Although DebriSat is an engineering model, specific attention is placed on the quality, type, and quantity of the materials used in its fabrication to ensure the integrity of the outcome. With the exception of software, all other aspects of the satellite s design, fabrication, and assembly integration and testing will be as rigorous as that of an actual flight vehicle. For example, to simulate survivability of launch loads, DebriSat will be subjected to a vibration test. As well, the satellite will undergo thermal vacuum tests to verify that the components and overall systems meet typical environmental standards. Proper assembly and integration techniques will involve comprehensive joint analysis, including the precise

  6. CERN: Fixed target targets

    International Nuclear Information System (INIS)

    Anon.

    1993-01-01

    Full text: While the immediate priority of CERN's research programme is to exploit to the full the world's largest accelerator, the LEP electron-positron collider and its concomitant LEP200 energy upgrade (January, page 1), CERN is also mindful of its long tradition of diversified research. Away from LEP and preparations for the LHC proton-proton collider to be built above LEP in the same 27-kilometre tunnel, CERN is also preparing for a new generation of heavy ion experiments using a new source, providing heavier ions (April 1992, page 8), with first physics expected next year. CERN's smallest accelerator, the LEAR Low Energy Antiproton Ring continues to cover a wide range of research topics, and saw a record number of hours of operation in 1992. The new ISOLDE on-line isotope separator was inaugurated last year (July, page 5) and physics is already underway. The remaining effort concentrates around fixed target experiments at the SPS synchrotron, which formed the main thrust of CERN's research during the late 1970s. With the SPS and LEAR now approaching middle age, their research future was extensively studied last year. Broadly, a vigorous SPS programme looks assured until at least the end of 1995. Decisions for the longer term future of the West Experimental Area of the SPS will have to take into account the heavy demand for test beams from work towards experiments at big colliders, both at CERN and elsewhere. The North Experimental Area is the scene of larger experiments with longer lead times. Several more years of LEAR exploitation are already in the pipeline, but for the longer term, the ambitious Superlear project for a superconducting ring (January 1992, page 7) did not catch on. Neutrino physics has a long tradition at CERN, and this continues with the preparations for two major projects, the Chorus and Nomad experiments (November 1991, page 7), to start next year in the West Area. Delicate neutrino oscillation effects could become

  7. Recent trends in repair and refurbishing of steam turbine components

    Indian Academy of Sciences (India)

    M. Senthilkumar (Newgen Imaging) 1461 1996 Oct 15 13:05:22

    be adequately addressed at various stages of its design and fabrication. ... lead to plant shutdown, loss in production and productivity, fire explosion, radiation or gas ..... component manufacturers, there is a growing necessity for in-house ...

  8. Scalable Fabrication of Integrated Nanophotonic Circuits on Arrays of Thin Single Crystal Diamond Membrane Windows.

    Science.gov (United States)

    Piracha, Afaq H; Rath, Patrik; Ganesan, Kumaravelu; Kühn, Stefan; Pernice, Wolfram H P; Prawer, Steven

    2016-05-11

    Diamond has emerged as a promising platform for nanophotonic, optical, and quantum technologies. High-quality, single crystalline substrates of acceptable size are a prerequisite to meet the demanding requirements on low-level impurities and low absorption loss when targeting large photonic circuits. Here, we describe a scalable fabrication method for single crystal diamond membrane windows that achieves three major goals with one fabrication method: providing high quality diamond, as confirmed by Raman spectroscopy; achieving homogeneously thin membranes, enabled by ion implantation; and providing compatibility with established planar fabrication via lithography and vertical etching. On such suspended diamond membranes we demonstrate a suite of photonic components as building blocks for nanophotonic circuits. Monolithic grating couplers are used to efficiently couple light between photonic circuits and optical fibers. In waveguide coupled optical ring resonators, we find loaded quality factors up to 66 000 at a wavelength of 1560 nm, corresponding to propagation loss below 7.2 dB/cm. Our approach holds promise for the scalable implementation of future diamond quantum photonic technologies and all-diamond photonic metrology tools.

  9. Fabrication of micro metallic valve and pump

    Science.gov (United States)

    Yang, Ming; Kabasawa, Yasunari; Ito, Kuniyoshi

    2010-03-01

    Fabrication of micro devices by using micro metal forming was proposed by the authors. We developed a desktop servo-press machine with precise tooling system. Precise press forming processes including micro forging and micro joining has been carried out in a progressive die. In this study, micro metallic valve and pump were fabricated by using the precise press forming. The components are made of sheet metals, and assembled in to a unit in the progressive die. A micro check-valve with a diameter of 3mm and a length of 3.2mm was fabricated, and the property of flow resistance was evaluated. The results show that the check valve has high property of leakage proof. Since the valve is a unit parts with dimensions of several millimeters, it has advantage to be adapted to various pump design. Here, two kinds of micro pumps with the check-valves were fabricated. One is diaphragm pump actuated by vibration of the diaphragm, and another is tube-shaped pump actuated by resonation. The flow quantities of the pumps were evaluated and the results show that both of the pumps have high pumping performance.

  10. Numerical Tools for Composite Woven Fabric Preforming

    Directory of Open Access Journals (Sweden)

    Abel Cherouat

    2013-01-01

    Full Text Available An important step in the manufacturing processes of thin composite components is the layingup of the reinforcement onto the mould surface. The prediction of the angular distortion of the reinforcement during draping and the changes in fibre orientation are essential for the understanding of the manufacture process and the evaluation of the mechanical properties of the composite structures. This paper presents an optimization-based method for the simulation of the forming processes of woven fabric reinforced composites. Two different approaches are proposed for the simulation of the draping of woven fabric onto complex geometries: geometrical and mechanical approaches. The geometrical approach is based on a fishnet model. It is well adapted to predimensioning fabrics and to give a suitable quantification of the resulting flat patterns. The mechanical approach is based on a mesostructural model. It allows us to take into account the mechanical properties of fibres and resin and the various dominating mode of deformation of woven fabrics during the forming process. Some numerical simulations of the forming process are proposed and compared with the experimental results in order to demonstrate the efficiency of our approaches.

  11. Dissolvable microneedle fabrication using piezoelectric dispensing technology.

    Science.gov (United States)

    Allen, Evin A; O'Mahony, Conor; Cronin, Michael; O'Mahony, Thomas; Moore, Anne C; Crean, Abina M

    2016-03-16

    Dissolvable microneedle (DMN) patches are novel dosage forms for the percutaneous delivery of vaccines. DMN are routinely fabricated by dispensing liquid formulations into microneedle-shaped moulds. The liquid formulation within the mould is then dried to create dissolvable vaccine-loaded microneedles. The precision of the dispensing process is critical to the control of formulation volume loaded into each dissolvable microneedle structure. The dispensing process employed must maintain vaccine integrity. Wetting of mould surfaces by the dispensed formulation is also an important consideration for the fabrication of sharp-tipped DMN. Sharp-tipped DMN are essential for ease of percutaneous administration. In this paper, we demonstrate the ability of a piezoelectric dispensing system to dispense picolitre formulation volumes into PDMS moulds enabling the fabrication of bilayer DMN. The influence of formulation components (trehalose and polyvinyl alcohol (PVA) content) and piezoelectric actuation parameters (voltage, frequency and back pressure) on drop formation is described. The biological integrity of a seasonal influenza vaccine following dispensing was investigated and maintained voltage settings of 30 V but undermined at higher settings, 50 and 80 V. The results demonstrate the capability of piezoelectric dispensing technology to precisely fabricate bilayer DMN. They also highlight the importance of identifying formulation and actuation parameters to ensure controlled droplet formulation and vaccine stabilisation. Copyright © 2015 Elsevier B.V. All rights reserved.

  12. Superphenix 1 intermediate heat exchanger fabrication

    International Nuclear Information System (INIS)

    Noel, H.; Granito, F.; Pouderoux, P.

    1985-01-01

    The eight Superphenix 375-MW (thermal) intermediate heat exchangers (IHXs) are similar in overall design to the Phenix components. Detailed design changes had to be made during fabrication on the following grounds: Due to seismic resistance, the support area was raised as high as possible to situate the component natural frequencies well out of the resonance peak range and remove thick plate-to-shell connections from heavy thermal load areas. Integration of lessons drawn from the Phenix incidents, due mainly to secondary sodium radial temperature disparities, resulted in the design of a more adaptable outlet header, together with a sodium mixing device, and in the reduction of temperature differences by heat insulation. To avoid circumferential temperature disparities, the iron shot biological shielding plug was replaced by stacked stainless steel plates within an outer shell, which in the new design, is not a supporting structure. The thermal-hydraulic and mechanical design of the component necessitated the elaboration of sophisticated computer codes, with validation of results on mock-ups. The detailed design studies and the actual manufacturing work had to adapt to both design developments and to inherent fabrication difficulties, mainly related to the very tight tolerances imposed for these exceptionally large components and to the welding of steel with an excessive boron content. The construction of the Creys-Malville IHXs afforded valuable industrial experience, which should provide a basis for the design of simpler and less costly IHX units for the forthcoming 1500-MW (electric) breeder

  13. Measurement of residual stresses in deposited films of SOFC component materials

    Energy Technology Data Exchange (ETDEWEB)

    Kato, T.; Momma, A.; Nagata, S.; Kasuga, Y. [Electrotechnical Lab., Ibaraki (Japan)

    1996-12-31

    The stress induced in Solid oxide fuel cells (SOFC)s has important influence on the lifetime of SOFC. But the data on stress in SOFC and mechanical properties of SOW component materials have not been accumulated enough to manufacture SOFC. Especially, the data of La{sub 1-x}Sr{sub x}MnO{sub 3} cathode and La{sub 1-x}Sr{sub x}CrO{sub 3} interconnection have been extremely limited. We have estimated numerically the dependences of residual stress in SOFC on the material properties, the cell structure and the fabrication temperatures of the components, but these unknown factors have caused obstruction to simulate the accurate behavior of residual stress. Therefore, the residual stresses in deposited La{sub 1-x}Sr{sub x}MnO{sub 3} and La{sub 1-x}Sr{sub x}CrO{sub 3} films are researched by the observation of the bending behavior of the substrate strips. The films of SOFC component materials were prepared by the RF sputtering method, because: (1) It can fabricate dense films of poor sinterable material such as La{sub 1-x}Sr{sub x}CrO{sub 3} compared with sintering or plasma spray method. (2) For the complicated material such as perovskite materials, the difference between the composition of a film and that of a target material is generally small. (3) It can fabricate a thick ceramics film by improving of the deposition rate. For example, Al{sub 2}O{sub 3} thick films of 50{mu}m can be fabricated with the deposition rate of approximately 5{mu}m/h industrially. In this paper, the dependence of residual stress on the deposition conditions is defined and mechanical properties of these materials are estimated from the results of the experiments.

  14. Description of ECRI (CNEA'S MTR fuel fabrication plant)

    International Nuclear Information System (INIS)

    Echenique, P.; Fabro, J.; Podesta, D.; Restelli, M.; Rossi, G.; Alvarez, L.; Adelfang, P.

    2002-01-01

    The ECRI Plant is dedicated to the development and fabrication of high-density fuel elements and targets for 99 Mo. In this sector had been done the start up Fuel Elements for the Reactors of Peru, Iran, Algeria and Egypt. All of them were made with U 3 O 8 . The targets for 99 Mo using HEU were fabricated too in the last years. The new material of high-density for Fuel Elements as U 3 Si 2 were done in this sector, three prototypes were fabricated, two are still under irradiation. (P06 and P07). As new developments we are working with U-Mo (7%) Fuel Plates with both material Korean and HMD. This work is under the RERTR Program and two fuel elements, manufactured by us, with both powders, will be irradiated in Petten. For 99 Mo targets, we are fabricating miniplates of LEU with an AlUx powder by pulvi-metallurgy technique. And it is under development the foils targets under the RERTR Program. A general view of the fabrication facilities and control sector will be shown. The different operations that are done in each sector will be explained. All our activities will be certified under the ISO 9000 and we are working hard to get it in the middle of 2003. (author)

  15. Target laboratory

    International Nuclear Information System (INIS)

    Ephraim, D.C.; Pednekar, A.R.

    1993-01-01

    A target laboratory to make stripper foils for the accelerator and various targets for use in the experiments is set up in the pelletron accelerator facility. The facilities available in the laboratory are: (1) D.C. glow discharge setup, (2) carbon arc set up, and (3) vacuum evaporation set up (resistance heating), electron beam source, rolling mill - all for target preparation. They are described. Centrifugal deposition technique is used for target preparation. (author). 3 figs

  16. FPGA fabric specific optimization for RLT design

    International Nuclear Information System (INIS)

    Perwaiz, A.; Khan, S.A.

    2010-01-01

    This paper proposes a technique custom to the optimization requirements suited for a particular family of Field Programmable Gate Arrays (FPGAs). As FPGAs have introduced re configurable black boxes there is a need to perform optimization across FPGAs slice fabric in order to achieve optimum performance. Though the Register Transfer Level (RTL) Hardware Descriptive Language (HDL) code should be technology independent but in many design instances it is imperative to understand the target technology especially once the target device embeds dedicated arithmetic blocks. No matter what the degree of optimization of the algorithm is, the configuration of target device plays an important role as far as the device utilization and path delays are concerned Index Terms: Field Programmable Gate Arrays (FPGA), Compression Tree, Bit Width Reduction, Look Ahead Pipelining. (author)

  17. Printable Materials for the Realization of High Performance RF Components: Challenges and Opportunities

    Directory of Open Access Journals (Sweden)

    Eva S. Rosker

    2018-01-01

    Full Text Available Printing methods such as additive manufacturing (AM and direct writing (DW for radio frequency (RF components including antennas, filters, transmission lines, and interconnects have recently garnered much attention due to the ease of use, efficiency, and low-cost benefits of the AM/DW tools readily available. The quality and performance of these printed components often do not align with their simulated counterparts due to losses associated with the base materials, surface roughness, and print resolution. These drawbacks preclude the community from realizing printed low loss RF components comparable to those fabricated with traditional subtractive manufacturing techniques. This review discusses the challenges facing low loss RF components, which has mostly been material limited by the robustness of the metal and the availability of AM-compatible dielectrics. We summarize the effective printing methods, review ink formulation, and the postprint processing steps necessary for targeted RF properties. We then detail the structure-property relationships critical to obtaining enhanced conductivities necessary for printed RF passive components. Finally, we give examples of demonstrations for various types of printed RF components and provide an outlook on future areas of research that will require multidisciplinary teams from chemists to RF system designers to fully realize the potential for printed RF components.

  18. Intraocular lens fabrication

    Energy Technology Data Exchange (ETDEWEB)

    Salazar, Mike A. (Albuquerque, NM); Foreman, Larry R. (Los Alamos, NM)

    1997-01-01

    This invention describes a method for fabricating an intraocular lens made rom clear Teflon.TM., Mylar.TM., or other thermoplastic material having a thickness of about 0.025 millimeters. These plastic materials are thermoformable and biocompatable with the human eye. The two shaped lenses are bonded together with a variety of procedures which may include thermosetting and solvent based adhesives, laser and impulse welding, and ultrasonic bonding. The fill tube, which is used to inject a refractive filling material is formed with the lens so as not to damage the lens shape. A hypodermic tube may be included inside the fill tube.

  19. Intraocular lens fabrication

    Energy Technology Data Exchange (ETDEWEB)

    Salazar, M.A.; Foreman, L.R.

    1997-07-08

    This invention describes a method for fabricating an intraocular lens made from clear Teflon{trademark}, Mylar{trademark}, or other thermoplastic material having a thickness of about 0.025 millimeters. These plastic materials are thermoformable and biocompatable with the human eye. The two shaped lenses are bonded together with a variety of procedures which may include thermosetting and solvent based adhesives, laser and impulse welding, and ultrasonic bonding. The fill tube, which is used to inject a refractive filling material is formed with the lens so as not to damage the lens shape. A hypodermic tube may be included inside the fill tube. 13 figs.

  20. Mask fabrication process

    Science.gov (United States)

    Cardinale, Gregory F.

    2000-01-01

    A method for fabricating masks and reticles useful for projection lithography systems. An absorber layer is conventionally patterned using a pattern and etch process. Following the step of patterning, the entire surface of the remaining top patterning photoresist layer as well as that portion of an underlying protective photoresist layer where absorber material has been etched away is exposed to UV radiation. The UV-exposed regions of the protective photoresist layer and the top patterning photoresist layer are then removed by solution development, thereby eliminating the need for an oxygen plasma etch and strip and chances for damaging the surface of the substrate or coatings.

  1. Advanced fabrication technology

    International Nuclear Information System (INIS)

    Sheely, W.F.

    1986-01-01

    The Fuel Cycle Plant is a multipurpose nuclear facility located on the Hanford Nuclear Reservation in eastern Washington state. The facility is part of the Hanford Engineering Development Laboratory which is operated by Westinghouse Hanford Company for the Department of Energy. The Fuel Cycle Plant is currently being prepared to support the Liquid Metal Reactors Program with fuel fabrication services for the Fast Flux Test Facility and other LMR programs. This report describes the technical innovations to be utilized in the operation of this plant

  2. Ice targets

    International Nuclear Information System (INIS)

    Pacheco, C.; Stark, C.; Tanaka, N.; Hodgkins, D.; Barnhart, J.; Kosty, J.

    1979-12-01

    This report presents a description of ice targets that were constructed for research work at the High Resolution Spectrometer (HRS) and at the Energetic Pion Channel and Spectrometer (EPICS). Reasons for using these ice targets and the instructions for their construction are given. Results of research using ice targets will be published at a later date

  3. Gel Fabrication of Molybdenum “Beads”

    Energy Technology Data Exchange (ETDEWEB)

    Lowden, Richard Andrew [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Materials Science and Technology Division; Armstrong, Beth L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Materials Science and Technology Division; Cooley, Kevin M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Materials Science and Technology Division

    2016-11-01

    Spherical molybdenum particles or “beads” of various diameters are of interest as feedstock materials for the additive manufacture of targets and assemblies used in the production of 99Mo medical isotopes using accelerator technology. Small metallic beads or ball bearings are typically fabricated from wire; however, small molybdenum spheres cannot readily be produced in this manner. Sol-gel processes are often employed to produce small dense microspheres of metal oxides across a broad diameter range that in the case of molybdenum could be reduced and sintered to produce metallic spheres. These Sol-gel type processes were examined for forming molybdenum oxide beads; however, the molybdenum trioxide was chemically incompatible with commonly used gelation materials. As an alternative, an aqueous alginate process being assessed for the fabrication of oxide spheres for catalyst applications was employed to form molybdenum trioxide beads that were successfully reduced and sintered to produce small molybdenum spheres.

  4. Directed light fabrication of refractory metals

    International Nuclear Information System (INIS)

    Lewis, G.K.; Thoma, D.J.; Nemec, R.B.; Milewski, J.O.

    1997-01-01

    Directed Light Fabrication (DLF) is a metal, rapid fabrication process that fuses metal powders to full density into a solid replica of a computer modeled component. It has been shown feasible for forming nearly any metal and also intermetallics to near net shape with a single process. DLF of refractory pure metals is feasible, bypassing the extensive series of conventional processing steps used for processing these high melting point materials. Tungsten, tantalum, and rhenium were processed and show a continuous resolidified microstructure. Porosity was a problem for the tantalum and rhenium powders produced by chemical reduction processes but not for the tungsten powder spherodized in a plasma arc. Chemical analysis of powder compared to the DLF deposit showed reductions in carbon, oxygen and hydrogen, indicating that process parameters may also be optimized for evolution of residual gases in the deposits

  5. Materials considerations in accelerator targets

    International Nuclear Information System (INIS)

    Peacock, H. B. Jr.; Iyer, N. C.; Louthan, M. R. Jr.

    1995-01-01

    Future nuclear materials production and/or the burn-up of long lived radioisotopes may be accomplished through the capture of spallation produced neutrons in accelerators. Aluminum clad-lead and/or lead alloys has been proposed as a spallation target. Aluminum was the cladding choice because of the low neutron absorption cross section, fast radioactivity decay, high thermal conductivity, and excellent fabricability. Metallic lead and lead oxide powders were considered for the target core with the fabrication options being casting or powder metallurgy (PM). Scoping tests to evaluate gravity casting, squeeze casting, and casting and swaging processes showed that, based on fabricability and heat transfer considerations, squeeze casting was the preferred option for manufacture of targets with initial core cladding contact. Thousands of aluminum clad aluminum-lithium alloy core targets and control rods for tritium production have been fabricated by coextrusion processes and successfully irradiated in the SRS reactors. Tritium retention in, and release from, the coextruded product was modeled from experimental and operational data. The model assumed that tritium atoms, formed by the 6Li(n,a)3He reaction, were produced in solid solution in the Al-Li alloy. Because of the low solubility of hydrogen isotopes in aluminum alloys, the irradiated Al-Li rapidly became supersaturated in tritium. Newly produced tritium atoms were trapped by lithium atoms to form a lithium tritide. The effective tritium pressure required for trap or tritide stability was the equilibrium decomposition pressure of tritium over a lithium tritide-aluminum mixture. The temperature dependence of tritium release was determined by the permeability of the cladding to tritium and the local equilibrium at the trap sites. The model can be used to calculate tritium release from aluminum clad, aluminum-lithium alloy targets during postulated accelerator operational and accident conditions. This paper describes

  6. Materials considerations in accelerator targets

    International Nuclear Information System (INIS)

    Peacock, H.B. Jr.; Iyer, N.C.; Louthan, M.R. Jr.

    1994-01-01

    Future nuclear materials production and/or the burn-up of long lived radioisotopes may be accomplished through the capture of spallation produced neutrons in accelerators. Aluminum clad-lead and/or lead alloys has been proposed as a spallation target. Aluminum was the cladding choice because of the low neutron absorption cross section, fast radioactivity decay, high thermal conductivity, and excellent fabricability. Metallic lead and lead oxide powders were considered for the target core with the fabrication options being casting or powder metallurgy (PM). Scoping tests to evaluate gravity casting, squeeze casting, and casting and swaging processes showed that, based on fabricability and heat transfer considerations, squeeze casting was the preferred option for manufacture of targets with initial core cladding contact. Thousands of aluminum clad aluminum-lithium alloy core targets and control rods for tritium production have been fabricated by coextrusion processes and successfully irradiated in the SRS reactors. Tritium retention in, and release from the coextruded product was modeled from experimental and operational data. Newly produced tritium atoms were trapped by lithium atoms to form a lithium tritide. The effective tritium pressure required for trap or tritide stability was the equilibrium decomposition pressure of tritium over a lithium tritide-aluminum mixture. The temperature dependence of tritium release was determined by the permeability of the cladding to tritium and the local equilibrium at the trap sites. The model can be used to calculate tritium release from aluminum clad, aluminum-lithium alloy targets during postulated accelerator operational and accident conditions. This paper describes the manufacturing technologies evaluated and presents the model for tritium retention in aluminum clad, aluminum-lithium alloy tritium production targets

  7. Fabrication of seamless calandria tubes

    International Nuclear Information System (INIS)

    Saibaba, N.; Phanibabu, C.; Bhaskara Rao, C.V.; Kalidas, R.; Ganguly, C.

    2002-01-01

    Full text: Calandria tube is a large diameter, thin walled zircaloy-4 tube and is an important structural component of PHWR type of reactors. These tubes are lifetime components and remain during the full life of the reactor. Calandria tubes are classified as extremely thin walled tubes with a diameter to wall thickness ratio of around 96. Such thin walled tubes are conventionally produced by seam welded route comprising of extrusion of slabs followed by a series of hot and rolling passes, shaping into O-shape and eventual welding. An alternative and superior method of fabricating the calandria tubes, the seamless route, has been developed, which involves hot extrusion of mother blanks followed by three successive cold pilger reductions. Eccentricity correction of the extruded blanks is carried out on a special purpose grinding equipment to bring the wall thickness variation within permissible limits. Predominant wall thickness reductions are given during cold pilgering to ensure high Q-factor values. The texture in the finished tubes could be closely, controlled with an average f r value of 0.65. Pilgering parameters and tube guiding system have been specially designed to facilities rolling of thin walled tubes. Seamless calandria tubes have distinct advantages over welded tubes. In addition to the absence of weld, they are dimensionally more stable, lighter in weight and possess uniform grains with superior grain size. The cycle time from billet to finished product is substantially reduced and the product is amenable to high level of quality assurance. The most significant feature of the seamless route is its material recovery over welded route. Residual stresses measured in the tubes indicate that these are negligible and uniform along the length of the tube. In view of their superior quality, the first charge of seamless calandria tubes will be rolled into the first 500 MWe Pressurised Heavy Water Reactor at Tarapur

  8. Fabrication of zein nanostructure

    Science.gov (United States)

    Luecha, Jarupat

    The concerns on the increase of polluting plastic wastes as well as the U.S. dependence on imported petrochemical products have driven an attention towards alternative biodegradable polymers from renewable resources. Zein protein, a co-product from ethanol production from corn, is a good candidate. This research project aims to increase zein value by adopting nanotechnology for fabricating advanced zein packaging films and zein microfluidic devices. Two nanotechnology approaches were focused: the polymer nanoclay nanocomposite technique where the nanocomposite structures were created in the zein matrix, and the soft lithography and the microfluidic devices where the micro and nanopatterns were created on the zein film surfaces. The polymer nanoclay nanocomposite technique was adopted in the commonly used zein film fabrication processes which were solvent casting and extrusion blowing methods. The two methods resulted in partially exfoliated nanocomposite structures. The impact of nanoclays on the physical properties of zein films strongly depended on the film preparation techniques. The impact of nanoclay concentration was more pronounced in the films made by extrusion blowing technique than by the solvent casting technique. As the processability limitation for the extrusion blowing technique of the zein sample containing hight nanoclay content, the effect of the nanoclay content on the rheological properties of zein hybrid resins at linear and nonlinear viscoelastic regions were further investigated. A pristine zein resin exhibited soft solid like behavior. On the other hand, the zein hybrid with nanoclay content greater than 5 wt.% showed more liquid like behavior, suggesting that the nanoclays interrupted the entangled zein network. There was good correspondence between the experimental data and the predictions of the Wagner model for the pristine zein resins. However, the model failed to predict the steady shear properties of the zein nanoclay nanocomposite

  9. Fabrication of Foam Shells for ICF Experiments

    Science.gov (United States)

    Czechowicz, D. G.; Acenas, O.; Flowers, J. S.; Nikroo, A.; Paguio, R. R.; Schroen, D. G.; Streit, J.; Takagi, M.

    2004-11-01

    The General Atomics/Schafer team has developed processes to fabricate foam shells targets suitable for ICF experiments. The two most common chemical systems used to produce foam shells have been resorcinol-formaldehyde (R/F) aerogel and divinylbenzene (DVB). Spherical targets have been made in the form of shells and beads having diameters ranging from approximately 0.5 mm to 4.0 mm, and having densities from approximately 100 mg/cc to 250 mg/cc. The work on R/F foam shells has been concentrated on 1) shell fabrication process improvement to obtain high yields ( ˜25%) and 2) depositing a reliable permeation barrier to provide shells for ongoing direct drive experiments at LLE. Development of divinylbenzene foam shells has been mainly directed towards Inertial Fusion Energy applications (at densities as low as 30 mg/cc) and recently for shells for experiments at LLE. Details of the relevant metrology and properties of these foams as well as the range of targets currently available will be discussed.

  10. National Ignition Facility Target Chamber

    International Nuclear Information System (INIS)

    Wavrik, R W; Cox, J R; Fleming, P J

    2000-01-01

    On June 11, 1999 the Department of Energy dedicated the single largest piece of the National Ignition Facility (NIF) at Lawrence Livermore National Laboratory (LLNL) in Livermore, California. The ten (10) meter diameter aluminum target high vacuum chamber will serve as the working end of the largest laser in the world. The output of 192 laser beams will converge at the precise center of the chamber. The laser beams will enter the chamber in two by two arrays to illuminate 10 millimeter long gold cylinders called hohlraums enclosing 2 millimeter capsule containing deuterium, tritium and isotopes of hydrogen. The two isotopes will fuse, thereby creating temperatures and pressures resembling those found only inside stars and in detonated nuclear weapons, but on a minute scale. The NIF Project will serve as an essential facility to insure safety and reliability of our nation's nuclear arsenal as well as demonstrating inertial fusion's contribution to creating electrical power. The paper will discuss the requirements that had to be addressed during the design, fabrication and testing of the target chamber. A team from Sandia National Laboratories (SNL) and LLNL with input from industry performed the configuration and basic design of the target chamber. The method of fabrication and construction of the aluminum target chamber was devised by Pitt-Des Moines, Inc. (PDM). PDM also participated in the design of the chamber in areas such as the Target Chamber Realignment and Adjustment System, which would allow realignment of the sphere laser beams in the event of earth settlement or movement from a seismic event. During the fabrication of the target chamber the sphericity tolerances had to be addressed for the individual plates. Procedures were developed for forming, edge preparation and welding of individual plates. Construction plans were developed to allow the field construction of the target chamber to occur parallel to other NIF construction activities. This was

  11. A Components Database Design and Implementation for Accelerators and Detectors

    International Nuclear Information System (INIS)

    Chan, A.; Meyer, S.

    2011-01-01

    Many accelerator and detector systems being fabricated for the PEP-II Accelerator and BABAR Detector needed configuration control and calibration measurements tracked for their components. Instead of building a database for each distinct system, a Components Database was designed and implemented that can encompass any type of component and any type of measurement. In this paper we describe this database design that is especially suited for the engineering and fabrication processes of the accelerator and detector environments where there are thousands of unique component types. We give examples of information stored in the Components Database, which includes accelerator configuration, calibration measurements, fabrication history, design specifications, inventory, etc. The World Wide Web interface is used to access the data, and templates are available for international collaborations to collect data off-line.

  12. Prognostics for Microgrid Components

    Science.gov (United States)

    Saxena, Abhinav

    2012-01-01

    Prognostics is the science of predicting future performance and potential failures based on targeted condition monitoring. Moving away from the traditional reliability centric view, prognostics aims at detecting and quantifying the time to impending failures. This advance warning provides the opportunity to take actions that can preserve uptime, reduce cost of damage, or extend the life of the component. The talk will focus on the concepts and basics of prognostics from the viewpoint of condition-based systems health management. Differences with other techniques used in systems health management and philosophies of prognostics used in other domains will be shown. Examples relevant to micro grid systems and subsystems will be used to illustrate various types of prediction scenarios and the resources it take to set up a desired prognostic system. Specifically, the implementation results for power storage and power semiconductor components will demonstrate specific solution approaches of prognostics. The role of constituent elements of prognostics, such as model, prediction algorithms, failure threshold, run-to-failure data, requirements and specifications, and post-prognostic reasoning will be explained. A discussion on performance evaluation and performance metrics will conclude the technical discussion followed by general comments on open research problems and challenges in prognostics.

  13. Evaluation methods for corrosion damage of components in cooling systems of nuclear power plants by coupling analysis of corrosion and flow dynamics (1). Major targets and development strategies of the evaluation methods

    International Nuclear Information System (INIS)

    Naitoh, Masanori; Uchida, Shunsuke; Koshizuka, Seiichi; Ninokata, Hisashi; Hiranuma, Naoki; Dosaki, Koji; Nishida, Koji; Akiyama, Minoru; Saitoh, Hiroaki

    2008-01-01

    Problems in major components and structural materials in nuclear power plants have often been caused by flow induced vibration and corrosion and their overlapping effects. In order to establish safe and reliable plant operation, future problems for structural materials should be predicted based on combined analyses of flow dynamics and corrosion and they should be mitigated before becoming serious issues for plant operation. Three approaches have been prepared for predicting future problems in structural materials: 1. Computer program packages for predicting future corrosion fatigue on structural materials, 2. Computer program packages for predicting future corrosion damage on structural materials, and 3. Computer program packages for predicting wall thinning caused by flow accelerated corrosion. General features of evaluation methods and their computer packages, technical innovations required for their development, and application plans for the developed approaches for plant operation are introduced in this paper. (author)

  14. Solid freeform fabrication of biological materials

    Science.gov (United States)

    Wang, Jiwen

    This thesis investigates solid freeform fabrication of biological materials for dental restoration and orthopedic implant applications. The basic approach in this study for solid freeform fabrication of biological materials is micro-extrusion of single or multiple slurries for 3D components and inkjet color printing of multiple suspensions for functionally graded materials (FGMs). Common issues associated with micro-extrusion and inkjet color printing are investigated. These common issues include (i) formulation of stable slurries with a pseudoplastic property, (ii) cross-sectional geometry of the extrudate as a function of the extrusion parameters, (iii) fabrication path optimization for extrusion process, (iv) extrusion optimization for multi-layer components, (v) composition control in functionally graded materials, and (vi) sintering optimization to convert the freeform fabricated powder compact to a dense body for biological applications. The present study clearly shows that the rheological and extrusion behavior of dental porcelain slurries depend strongly on the pH value of the slurry and extrusion conditions. A slurry with pseudoplastic properties is a basic requirement for obtaining extruded lines with rectangular cross-sections. The cross-sectional geometry of the extrudate is also strongly affected by extrusion parameters including the extrusion nozzle height, nozzle moving speed, extrusion rate, and critical nozzle height. Proper combinations of these extrusion parameters are necessary in order to obtain single line extrudates with near rectangular cross-sections and 3D objects with dimensional accuracy, uniform wall thickness, good wall uprightness, and no wall slumping. Based on these understandings, single-wall, multi-wall, and solid teeth have been fabricated via micro-extrusion of the dental slurry directly from a CAD digital model in 30 min. Inkjet color printing using stable Al2O3 and ZrO 2 aqueous suspensions has been developed to fabricate

  15. Intentionally fabricated autobiographical memories.

    Science.gov (United States)

    Justice, Lucy V; Morrison, Catriona M; Conway, Martin A

    2018-02-01

    Participants generated both autobiographical memories (AMs) that they believed to be true and intentionally fabricated autobiographical memories (IFAMs). Memories were constructed while a concurrent memory load (random 8-digit sequence) was held in mind or while there was no concurrent load. Amount and accuracy of recall of the concurrent memory load was reliably poorer following generation of IFAMs than following generation of AMs. There was no reliable effect of load on memory generation times; however, IFAMs always took longer to construct than AMs. Finally, replicating previous findings, fewer IFAMs had a field perspective than AMs, IFAMs were less vivid than AMs, and IFAMs contained more motion words (indicative of increased cognitive load). Taken together, these findings show a pattern of systematic differences that mark out IFAMs, and they also show that IFAMs can be identified indirectly by lowered performance on concurrent tasks that increase cognitive load.

  16. NCSX Vacuum Vessel Fabrication

    International Nuclear Information System (INIS)

    Viola ME; Brown T; Heitzenroeder P; Malinowski F; Reiersen W; Sutton L; Goranson P; Nelson B; Cole M; Manuel M; McCorkle D.

    2005-01-01

    The National Compact Stellarator Experiment (NCSX) is being constructed at the Princeton Plasma Physics Laboratory (PPPL) in conjunction with the Oak Ridge National Laboratory (ORNL). The goal of this experiment is to develop a device which has the steady state properties of a traditional stellarator along with the high performance characteristics of a tokamak. A key element of this device is its highly shaped Inconel 625 vacuum vessel. This paper describes the manufacturing of the vessel. The vessel is being fabricated by Major Tool and Machine, Inc. (MTM) in three identical 120 o vessel segments, corresponding to the three NCSX field periods, in order to accommodate assembly of the device. The port extensions are welded on, leak checked, cut off within 1-inch of the vessel surface at MTM and then reattached at PPPL, to accommodate assembly of the close-fitting modular coils that surround the vessel. The 120 o vessel segments are formed by welding two 60 o segments together. Each 60 o segment is fabricated by welding ten press-formed panels together over a collapsible welding fixture which is needed to precisely position the panels. The vessel is joined at assembly by welding via custom machined 8-inch (20.3 cm) wide spacer ''spool pieces''. The vessel must have a total leak rate less than 5 X 10 -6 t-l/s, magnetic permeability less than 1.02(micro), and its contours must be within 0.188-inch (4.76 mm). It is scheduled for completion in January 2006

  17. Design & fabrication of cantilever array biosensors

    DEFF Research Database (Denmark)

    Boisen, Anja; Thundat, T

    2009-01-01

    Surface immobilization of functional receptors on microfabricated cantilever arrays offers a new paradigm for the development of biosensors based on nanomechanics. Microcantilever-based systems are capable of real-time, multiplexed detection of unlabeled disease markers in extremely small volumes......, electronic processing, and even local telemetry on a single chip have the potential of satisfying the need for highly sensitive and selective multiple-target detection in very small samples. Here we will review the design and fabrication process of cantilever-based biosensors....

  18. Empowering academia through modern fabrication practices

    DEFF Research Database (Denmark)

    Padfield, Nicolas; Haldrup, Michael; Hobye, Mads

    We posit that modern fabrication and rapid prototyping practices can empower non-technical academic environments. For this to resonate with academic learning and research environments in a university context we must view FabLabs not only as machine parks but as creative environments, producing...... knowledge contributions in the form of processes, designs, artifacts and products. We must embrace thinking through the material, and embrace physical products as valid, accessible and assessable on an equal footing with traditional textual media. We describe two cases: workshops focused on exploration...... through the physical and digital media itself, without a traditional textual component....

  19. Fabrication of superhydrophobic cotton fabrics using crosslinking polymerization method

    Science.gov (United States)

    Jiang, Bin; Chen, Zhenxing; Sun, Yongli; Yang, Huawei; Zhang, Hongjie; Dou, Haozhen; Zhang, Luhong

    2018-05-01

    With the aim of removing and recycling oil and organic solvent from water, a facile and low-cost crosslinking polymerization method was first applied on surface modification of cotton fabrics for water/oil separation. Micro-nano hierarchical rough structure was constructed by triethylenetetramine (TETA) and trimesoyl chloride (TMC) that formed a polymeric layer on the surface of the fabric and anchored Al2O3 nanoparticles firmly between the fabric surface and the polymer layer. Superhydrophobic property was further obtained through self-assembly grafting of hydrophobic groups on the rough surface. The as-prepared cotton fabric exhibited superoleophilicity in atmosphere and superhydrophobicity both in atmosphere and under oil with the water contact angle of 153° and 152° respectively. Water/oil separation test showed that the as-prepared cotton fabric can handle with various oil-water mixtures with a high separation efficiency over 99%. More importantly, the separation efficiency remained above 98% over 20 cycles of reusing without losing its superhydrophobicity which demonstrated excellent reusability in oil/water separation process. Moreover, the as-prepared cotton fabric possessed good contamination resistance ability and self-cleaning property. Simulation washing process test showed the superhydrophobic cotton fabric maintained high value of water contact angle above 150° after 100 times washing, indicating great stability and durability. In summary, this work provides a brand-new way to surface modification of cotton fabric and makes it a promising candidate material for oil/water separation.

  20. CACAO facility. Radioactive targets at Orsay

    International Nuclear Information System (INIS)

    Bacri, C.O.; Petitbon-Thevenet, V.; Mottier, J.; Lefort, H.; Durnez, A.; Fortuna, F.

    2014-01-01

    CACAO, Chimie des Actinides et Cibles radioActives a Orsay (actinide chemistry and radioactive targets at Orsay), is a new laboratory dedicated to the fabrication and characterization of radioactive targets. It is supported by the radiochemistry group and the stable target service of the IPNO. The recurring needs of physicists working in the nuclear fuel cycle physics and the growing difficulties to obtain radioactive targets elsewhere were the main motivating factors behind the construction of this new laboratory. The first targets of 235,238 U and 232 Th have already been prepared although the full operating licenses still need to be obtained. In this paper, the installation and the equipment of CACAO will be described. An extensive study of a U test target fabricated by the CACAO laboratory has been performed and results are reported here. The different techniques used to characterize the deposit are presented and the outcome is discussed. (author)

  1. Legal Issues in Cyber Targeting

    DEFF Research Database (Denmark)

    Juhlin, Jonas Alastair

    Imagine this scenario: Two states are in armed conflict with each other. In order to gain an advantage, one side launches a cyber-attack against the opponent’s computer network. The malicious malware paralyze the military computer network, as intended, but the malware spreads into the civilian...... system with physical damage to follow. This can happen and the natural question arises: What must be considered lawful targeting according to the international humanitarian law in cyber warfare? What steps must an attacker take to minimize the damage done to unlawful targets when conducting an offensive...... operation? How can the attacker separate military targets from civilian targets in cyber space? This paper addresses these questions and argues that a network (civilian or military) consist of several software components and that it is the individual components that is the target. If the components are used...

  2. Acceptance criteria for the ITER divertor vertical target

    International Nuclear Information System (INIS)

    Fouquet, S.; Schlosser, J.; Merola, M.; Durocher, A.; Escourbiac, F.; Grosman, A.; Missirlian, M.; Portafaix, C.

    2006-01-01

    In the frame of the toroidal pump limiter fabrication for Tore Supra, CEA developed a large experience of infrared test for acceptance of high heat flux components armoured with carbon fibre composite flat tiles. The test is based on a thermal transient induced by an alternative hot/cold water flow in the heat sink structure. The tile surface temperature transients are compared with those of a reference element, the maximum difference for each tile leading to a value called ΔT ref m ax . This method is proposed for the commissioning of plasma facing components for the ITER divertor vertical target. This paper describes the determination of the best acceptance criteria for the 'monoblock' geometry of the carbon part. First, it has been shown that the location and the extension of the defects could reliably be determined by monitoring both top and lateral surfaces during the test. Second, it was possible to fix an acceptance method based on ΔT ref m ax . Samples with calibrated defects are now under fabrication to validate the results

  3. The Helicobacter pylori HpyAXII restriction–modification system limits exogenous DNA uptake by targeting GTAC sites but shows asymmetric conservation of the DNA methyltransferase and restriction endonuclease components

    Science.gov (United States)

    Humbert, Olivier; Salama, Nina R.

    2008-01-01

    The naturally competent organism Helicobacter pylori encodes a large number of restriction–modification (R–M) systems that consist of a restriction endonuclease and a DNA methyltransferase. R–M systems are not only believed to limit DNA exchange among bacteria but may also have other cellular functions. We report a previously uncharacterized H. pylori type II R–M system, M.HpyAXII/R.HpyAXII. We show that this system targets GTAC sites, which are rare in the H. pylori chromosome but numerous in ribosomal RNA genes. As predicted, this type II R–M system showed attributes of a selfish element. Deletion of the methyltransferase M.HpyAXII is lethal when associated with an active endonuclease R.HpyAXII unless compensated by adaptive mutation or gene amplification. R.HpyAXII effectively restricted both unmethylated plasmid and chromosomal DNA during natural transformation and was predicted to belong to the novel ‘half pipe’ structural family of endonucleases. Analysis of a panel of clinical isolates revealed that R.HpyAXII was functional in a small number of H. pylori strains (18.9%, n = 37), whereas the activity of M.HpyAXII was highly conserved (92%, n = 50), suggesting that GTAC methylation confers a selective advantage to H. pylori. However, M.HpyAXII activity did not enhance H. pylori fitness during stomach colonization of a mouse infection model. PMID:18978016

  4. Simultaneous Replication of both Refractive and Diffractive Optical Components using Electroformed Tools and Injection Moulding

    DEFF Research Database (Denmark)

    Tang, Peter Torben; Christensen, Thomas R.

    2003-01-01

    This research project has demonstrated that with carefully selected processes it is possible to fabricate tools for injection moulding of both diffractive and refractive optical components. The fabrication procedure is based on an aluminium disc on which selected optical components (gratings and ...

  5. Engineering shadows to fabricate optical metasurfaces.

    Science.gov (United States)

    Nemiroski, Alex; Gonidec, Mathieu; Fox, Jerome M; Jean-Remy, Philip; Turnage, Evan; Whitesides, George M

    2014-11-25

    Optical metasurfaces-patterned arrays of plasmonic nanoantennas that enable the precise manipulation of light-matter interactions-are emerging as critical components in many nanophotonic materials, including planar metamaterials, chemical and biological sensors, and photovoltaics. The development of these materials has been slowed by the difficulty of efficiently fabricating patterns with the required combinations of intricate nanoscale structure, high areal density, and/or heterogeneous composition. One convenient strategy that enables parallel fabrication of periodic nanopatterns uses self-assembled colloidal monolayers as shadow masks; this method has, however, not been extended beyond a small set of simple patterns and, thus, has remained incompatible with the broad design requirements of metasurfaces. This paper demonstrates a technique-shadow-sphere lithography (SSL)-that uses sequential deposition from multiple angles through plasma-etched microspheres to expand the variety and complexity of structures accessible by colloidal masks. SSL harnesses the entire, relatively unexplored, space of shadow-derived shapes and-with custom software to guide multiangled deposition-contains sufficient degrees of freedom to (i) design and fabricate a wide variety of metasurfaces that incorporate complex structures with small feature sizes and multiple materials and (ii) generate, in parallel, thousands of variations of structures for high-throughput screening of new patterns that may yield unexpected optical spectra. This generalized approach to engineering shadows of spheres provides a new strategy for efficient prototyping and discovery of periodic metasurfaces.

  6. Fabrication issues and technology development for HELEOS

    International Nuclear Information System (INIS)

    Susoeff, A.R.; Hawke, R.S.; Balk, J.K.; Hall, C.A.; McDonald, M.J.

    1989-01-01

    Starfire is a joint railgun of Lawrence Livermore National Laboratory and Sandia National Laboratory-Albuquerque. The goal of Starfire is to develop a Hypervelocity Electromagnetic Launcher for Equation of State (HELEOS) experiments. A two-stage light-gas gun is used as a pre-injector. Each round-bore HELEOS railgun module is 12.7 mm in diameter and 2.4 m long. The muzzle end of the railgun is connected to a vacuum tank. Common materials and fabrication technology are used in the manufacture of all components, and modular design allows for extending the length of the railgun as progress dictates. The launcher uses a ''vee block'' geometry, which is designed to: (1) provide compressive preload, (2) operate with a 300-MPa (3-kbar) internal bore pressure, and (3) easily accommodate interchangeable materials in the bore support structure and rail. The authors have performed full-scale material testing of the railgun and have developed a precision round-bore fabrication process. Air-gage inspection is used to determine bore diameter and straightness. They have also developed a surface mapping system to document the surface topography of the bore before and after an experiment. This paper presents fabrication details, results of tests conducted, and areas for potential improvement

  7. Fabrication challenges for indium phosphide microsystems

    International Nuclear Information System (INIS)

    Siwak, N P; Fan, X Z; Ghodssi, R

    2015-01-01

    From the inception of III–V microsystems, monolithically integrated device designs have been the motivating drive for this field, bringing together the utility of single-chip microsystems and conventional fabrication techniques. Indium phosphide (InP) has a particular advantage of having a direct bandgap within the low loss telecommunication wavelength (1550 nm) range, able to support passive waveguiding and optical amplification, detection, and generation depending on the exact alloy of In, P, As, Ga, or Al materials. Utilizing epitaxy, one can envision the growth of a substrate that contains all of the components needed to establish a single-chip optical microsystem, containing detectors, sources, waveguides, and mechanical structures. A monolithic InP MEMS system has, to our knowledge, yet to be realized due to the significant difficulties encountered when fabricating the integrated devices. In this paper we present our own research and consolidate findings from other research groups across the world to give deeper insight into the practical aspects of InP monolithic microsystem development: epitaxial growth of InP-based alloys, etching techniques, common MEMS structures realized in InP, and future applications. We pay special attention to shedding light on considerations that must be taken when designing and fabricating a monolithic InP MEMS device. (topical review)

  8. Design and fabrication of NDA standards

    International Nuclear Information System (INIS)

    Long, S.M.; Hsue, S.T.

    1996-01-01

    The Plutonium Facility, TA-55, at Los Alamos National Laboratory is currently producing NDA calibration standards used by various laboratories in the DOE complex. These NIST traceable standards have been produced to calibrate NDA instruments for accountability measurements used for resolving shipper/receiver differences, and for accountability in process residues and process waste. Standards are needed to calibrate various NDA (Non-destructive Assay) instruments such as neutron coincidence counters, gamma-ray counters, and calorimeters. These instruments measure various ranges of nuclear material being produced in the DOE nuclear community. Los Alamos National Laboratory has taken a lead role in fabrication of uranium and plutonium standards, along with other actinides such as neptunium and americium. These standards have been fabricated for several laboratories within the complex. This paper will summarize previous publications detailing the careful planning encompassing components such as precise weighing, destructive analysis, and the use of post fabrication NDA measurements to confirm that the standards meet all preliminary expectations before use in instrument calibration. The paper will also describe the specialized containers, diluents, and the various amount of nuclear materials needed to accommodate the calibration ranges of the instruments

  9. Wafer-scale micro-optics fabrication

    Science.gov (United States)

    Voelkel, Reinhard

    2012-07-01

    Micro-optics is an indispensable key enabling technology for many products and applications today. Probably the most prestigious examples are the diffractive light shaping elements used in high-end DUV lithography steppers. Highly-efficient refractive and diffractive micro-optical elements are used for precise beam and pupil shaping. Micro-optics had a major impact on the reduction of aberrations and diffraction effects in projection lithography, allowing a resolution enhancement from 250 nm to 45 nm within the past decade. Micro-optics also plays a decisive role in medical devices (endoscopes, ophthalmology), in all laser-based devices and fiber communication networks, bringing high-speed internet to our homes. Even our modern smart phones contain a variety of micro-optical elements. For example, LED flash light shaping elements, the secondary camera, ambient light and proximity sensors. Wherever light is involved, micro-optics offers the chance to further miniaturize a device, to improve its performance, or to reduce manufacturing and packaging costs. Wafer-scale micro-optics fabrication is based on technology established by the semiconductor industry. Thousands of components are fabricated in parallel on a wafer. This review paper recapitulates major steps and inventions in wafer-scale micro-optics technology. The state-of-the-art of fabrication, testing and packaging technology is summarized.

  10. Literature evidence in open targets - a target validation platform.

    Science.gov (United States)

    Kafkas, Şenay; Dunham, Ian; McEntyre, Johanna

    2017-06-06

    We present the Europe PMC literature component of Open Targets - a target validation platform that integrates various evidence to aid drug target identification and validation. The component identifies target-disease associations in documents and ranks the documents based on their confidence from the Europe PMC literature database, by using rules utilising expert-provided heuristic information. The confidence score of a given document represents how valuable the document is in the scope of target validation for a given target-disease association by taking into account the credibility of the association based on the properties of the text. The component serves the platform regularly with the up-to-date data since December, 2015. Currently, there are a total number of 1168365 distinct target-disease associations text mined from >26 million PubMed abstracts and >1.2 million Open Access full text articles. Our comparative analyses on the current available evidence data in the platform revealed that 850179 of these associations are exclusively identified by literature mining. This component helps the platform's users by providing the most relevant literature hits for a given target and disease. The text mining evidence along with the other types of evidence can be explored visually through https://www.targetvalidation.org and all the evidence data is available for download in json format from https://www.targetvalidation.org/downloads/data .

  11. CW RFQ fabrication and engineering

    International Nuclear Information System (INIS)

    Schrage, D.; Young, L.; Roybal, P.

    1998-01-01

    The design and fabrication of a four-vane RFQ to deliver a 100 mA CW proton beam at 6.7 MeV is described. This linac is an Oxygen-Free Electrolytic (OFE) copper structure 8 m in length and was fabricated using hydrogen furnace brazing as the joining technology

  12. Fabrication methods for mesoscopic flying vehicle

    Science.gov (United States)

    Cheng, Yih-Lin

    2001-10-01

    Small-scale flying vehicles are attractive tools for atmospheric science research. A centimeter-size mesoscopic electric helicopter, the mesicopter, has been developed at Stanford University for these applications. The mesoscopic scale implies a design with critical features between tens of microns and several millimeters. Three major parts in the mesicopter are challenging to manufacture. Rotors require smooth 3D surfaces and a blade thickness of less than 100 mum. Components in the DC micro-motor must be made of engineering materials, which is difficult on the mesoscopic scale. Airframe fabrication has to integrate complex 3D geometry into one single structure at this scale. In this research, material selection and manufacturing approaches have been investigated and implemented. In rotor fabrication, high-strength polymers manufactured by the Shape Deposition Manufacturing (SDM) technique were the top choice. Aluminum alloys were only considered as the second choice because the fabrication process is more involved. Lift tests showed that the 4-blade polymer and aluminum rotors could deliver about 90% of the expected lift (4g). To explain the rotor performance, structural analyses of spinning rotors were performed and the fabricated geometry was investigated. The bending deflections and the torsional twists were found to be too small to degrade aerodynamic performance. The rotor geometry was verified by laser scanning and by cross-section observations. Commercially available motors are used in the prototypes but a smaller DC micro-motor was designed for future use. Components of the DC micro-motors were fabricated by the Mesoscopic Additive/Subtractive Material Processing technique, which is capable of shaping engineering materials on the mesoscopic scale. The approaches are described in this thesis. The airframe was manufactured using the SDM process, which is capable of building complex parts without assembly. Castable polymers were chosen and mixed with glass

  13. DRAPING SIMULATION OF WOVEN FABRICS

    Energy Technology Data Exchange (ETDEWEB)

    Rodgers, William [General Motors LLC; Jin, Xiaoshi [ESI Group NA; Zhu, Jiang [Optimal CAE; Wathen, Terrence [General Motors LLC; Doroudian2, Mark [ESI Group NA; Aitharaju, Venkat [General Motors LLC

    2016-09-07

    Woven fabric composites are extensively used in molding complex geometrical shapes due to their high conformability compared to other fabrics. Preforming is an important step in the overall process, where the two-dimensional fabric is draped to become the three-dimensional shape of the part prior to resin injection. During preforming, the orientation of the yarns may change significantly compared to the initial orientations. Accurate prediction of the yarn orientations after molding is important for evaluating the structural performance of the final part. This paper presents a systematic investigation of the angle changes during the preform operation for carbon fiber twill and satin weave fabrics. Preforming experiments were conducted using a truncated pyramid mold geometry designed and fabricated at the General Motors Research Laboratories. Predicted results for the yarn orientations were compared with experimental results and good agreement was observed

  14. Fabrication and characterization of a slanting-type solar water ...

    African Journals Online (AJOL)

    The system includes four major components; a wooden basin of surface area 0.16 m2, an absorber surface, a slanting glass roof and a condensate channel. Very cheap locally available materials were used to fabricate the solar still. The solar still produced an average of 0.09 m3 of distilled water per day, and this study was ...

  15. Evaluation of Fine Denier and Microdenier Multifilament Fabrics

    National Research Council Canada - National Science Library

    Winterhalter, C

    2002-01-01

    ... to MIL-C-3924, Cloth, Oxford, Cotton Warp and Nylon Filling, Quarpel Treated. MIL-C-3924 is one of the military's lightest weight water repellent fabrics and is used in the Snow Camouflage Overwhites and various hood components and caps...

  16. Thin film solar cell configuration and fabrication method

    Science.gov (United States)

    Menezes, Shalini

    2009-07-14

    A new photovoltaic device configuration based on an n-copper indium selenide absorber and a p-type window is disclosed. A fabrication method to produce this device on flexible or rigid substrates is described that reduces the number of cell components, avoids hazardous materials, simplifies the process steps and hence the costs for high volume solar cell manufacturing.

  17. Antiproton Target

    CERN Multimedia

    1980-01-01

    Antiproton target used for the AA (antiproton accumulator). The first type of antiproton production target used from 1980 to 1982 comprised a rod of copper 3mm diameter and 120mm long embedded in a graphite cylinder that was itself pressed into a finned aluminium container. This assembly was air-cooled and it was used in conjunction with the Van der Meer magnetic horn. In 1983 Fermilab provided us with lithium lenses to replace the horn with a view to increasing the antiproton yield by about 30%. These lenses needed a much shorter target made of heavy metal - iridium was chosen for this purpose. The 50 mm iridium rod was housed in an extension to the original finned target container so that it could be brought very close to the entrance to the lithium lens. Picture 1 shows this target assembly and Picture 2 shows it mounted together with the lithium lens. These target containers had a short lifetime due to a combination of beam heating and radiation damage. This led to the design of the water-cooled target in...

  18. Secure Automated Fabrication: an overview of remote breeder fuel fabrication

    International Nuclear Information System (INIS)

    Nyman, D.H.; Graham, R.A.

    1983-10-01

    The Secure Automated Fabrication (SAF) line is an automated, remotely controlled breeder fuel pin fabrication process which is to be installed in the Fuels and Materials Examination Facility (FMEF). The FMEF is presently under construction at Hanford and is scheduled for completion in 1984. The SAF line is scheduled for startup in 1987 and will produce mixed uranium-plutonium fuel pins for the Fast Flux Test Facility (FFTF) and the Clinch River Breeder Reactor Plant (CRBRP). The fabrication line and support systems are described

  19. Radiation-resistant beamline components at LAMPF

    International Nuclear Information System (INIS)

    Macek, R.J.; Grisham, D.L.; Lambert, J.e.; Werbeck, R.

    1983-01-01

    A variety of highly radiation-resistant beamline components have been successfully developed at LAMPF primarily for use in the target cells and beam stop area of the intense proton beamline. Design features and operating experience are reviewed for magnets, instrumentation, targets, vacuum seals, vacuum windows, collimators, and beam stops

  20. MOX fuel fabrication at AECL

    International Nuclear Information System (INIS)

    Dimayuga, F.C.; Jeffs, A.T.

    1995-01-01

    Atomic Energy of Canada Limited's mixed-oxide (MOX) fuel fabrication activities are conducted in the Recycle Fuel Fabrication Laboratories (RFFL) at the Chalk River Laboratories. The RFFL facility is designed to produce experimental quantities of CANDU MOX fuel for reactor physics tests or demonstration irradiations. From 1979 to 1987, several MOX fuel fabrication campaigns were run in the RFFL, producing various quantities of fuel with different compositions. About 150 bundles, containing over three tonnes of MOX, were fabricated in the RFFL before operations in the facility were suspended. In late 1987, the RFFL was placed in a state of active standby, a condition where no fuel fabrication activities are conducted, but the monitoring and ventilation systems in the facility are maintained. Currently, a project to rehabilitate the RFFL and resume MOX fuel fabrication is nearing completion. This project is funded by the CANDU Owners' Group (COG). The initial fabrication campaign will consist of the production of thirty-eight 37-element (U,Pu)O 2 bundles containing 0.2 wt% Pu in Heavy Element (H.E.) destined for physics tests in the zero-power ZED-2 reactor. An overview of the Rehabilitation Project will be given. (author)

  1. 3D Printing Multi-Functionality: Embedded RF Antennas and Components

    Science.gov (United States)

    Shemelya, C. M.; Zemba, M.; Liang, M.; Espalin, D.; Kief, C.; Xin, H.; Wicker, R. B.; MacDonald, E. W.

    2015-01-01

    Significant research and press has recently focused on the fabrication freedom of Additive Manufacturing (AM) to create both conceptual models and final end-use products. This flexibility allows design modifications to be immediately reflected in 3D printed structures, creating new paradigms within the manufacturing process. 3D printed products will inevitably be fabricated locally, with unit-level customization, optimized to unique mission requirements. However, for the technology to be universally adopted, the processes must be enhanced to incorporate additional technologies; such as electronics, actuation, and electromagnetics. Recently, a novel 3D printing platform, Multi3D manufacturing, was funded by the presidential initiative for revitalizing manufacturing in the USA using 3D printing (America Makes - also known as the National Additive Manufacturing Innovation Institute). The Multi3D system specifically targets 3D printed electronics in arbitrary form; and building upon the potential of this system, this paper describes RF antennas and components fabricated through the integration of material extrusion 3D printing with embedded wire, mesh, and RF elements.

  2. Fabric circuits and method of manufacturing fabric circuits

    Science.gov (United States)

    Chu, Andrew W. (Inventor); Dobbins, Justin A. (Inventor); Scully, Robert C. (Inventor); Trevino, Robert C. (Inventor); Lin, Greg Y. (Inventor); Fink, Patrick W. (Inventor)

    2011-01-01

    A flexible, fabric-based circuit comprises a non-conductive flexible layer of fabric and a conductive flexible layer of fabric adjacent thereto. A non-conductive thread, an adhesive, and/or other means may be used for attaching the conductive layer to the non-conductive layer. In some embodiments, the layers are attached by a computer-driven embroidery machine at pre-determined portions or locations in accordance with a pre-determined attachment layout before automated cutting. In some other embodiments, an automated milling machine or a computer-driven laser using a pre-designed circuit trace as a template cuts the conductive layer so as to separate an undesired portion of the conductive layer from a desired portion of the conductive layer. Additional layers of conductive fabric may be attached in some embodiments to form a multi-layer construct.

  3. Fabrication of cotton fabric with superhydrophobicity and flame retardancy.

    Science.gov (United States)

    Zhang, Ming; Wang, Chengyu

    2013-07-25

    A simple and facile method for fabricating the cotton fabric with superhydrophobicity and flame retardancy is described in the present work. The cotton fabric with the maximal WCA of 160° has been prepared by the covalent deposition of amino-silica nanospheres and the further graft with (heptadecafluoro-1,1,2,2-tetradecyl) trimethoxysilane. The geometric microstructure of silica spheres was measured by transmission electron microscopy (TEM). The cotton textiles before and after treatment were characterized by using scanning electron microscope (SEM) and X-ray photoelectron spectroscopy (XPS). The wetting behavior of cotton samples was investigated by water contact angle measurement. Moreover, diverse performances of superhydrophobic cotton textiles have been evaluated as well. The results exhibited the outstanding superhydrophobicity, excellent waterproofing durability and flame retardancy of the cotton fabric after treatment, offering a good opportunity to accelerate the large-scale production of superhydrophobic textiles materials for new industrial applications. Copyright © 2013 Elsevier Ltd. All rights reserved.

  4. Fabrication of nanowires and nanostructures

    DEFF Research Database (Denmark)

    Mátéfi-Tempfli, Stefan; Mátéfi-Tempfli, M.; Piraux, L.

    2009-01-01

    We report on different approaches that we have adopted and developed for the fabrication of nanowires and nanostructures. Methods based on template synthesis and on self organization seem to be the most promising for the fabrication of nanomaterials and nanostructures due to their easiness and low...... cost. The development of a supported nanoporous alumina template and the possibility of using this template to combine electrochemical synthesis with lithographic methods open new ways for the fabrication of complex nanostructures. The numerous advantages of the supported template and its compatibility...

  5. Quantum Bridge Fabrication Using Photolithography

    International Nuclear Information System (INIS)

    Quinones, R.

    2001-01-01

    The need for high-speed performance electronics in computers integrated circuits and sensors, require the fabrication of low energy consumption diodes. Nano fabrication methods require new techniques and equipment. We are currently developing a procedure to fabricate a diode based on quantum-effects. The device will act like a traditional diode, but the nanometer scale will allow it to reach high speeds without over heating. This new diode will be on a nano-bridge so it can be attenuated by an electromagnetic wave. The goal is to obtain similar current vs voltage response as in a silicon diode

  6. Fabricating Copper Nanotubes by Electrodeposition

    Science.gov (United States)

    Yang, E. H.; Ramsey, Christopher; Bae, Youngsam; Choi, Daniel

    2009-01-01

    Copper tubes having diameters between about 100 and about 200 nm have been fabricated by electrodeposition of copper into the pores of alumina nanopore membranes. Copper nanotubes are under consideration as alternatives to copper nanorods and nanowires for applications involving thermal and/or electrical contacts, wherein the greater specific areas of nanotubes could afford lower effective thermal and/or electrical resistivities. Heretofore, copper nanorods and nanowires have been fabricated by a combination of electrodeposition and a conventional expensive lithographic process. The present electrodeposition-based process for fabricating copper nanotubes costs less and enables production of copper nanotubes at greater rate.

  7. Target technologies for laser inertial confinement fusion: state-of-the-art and future perspective

    International Nuclear Information System (INIS)

    Zhang Lin; Du Kai

    2013-01-01

    Targets are physical base of the laser inertial confinement fusion (ICF) researches. The quality of the targets has extremely important influences on the reliabilities and degree of precision of the ICF experimental results. The characteristics of the ICF targets, such as complexity and microscale, high precision, determine that the target fabrication process must be a system engineering. This paper presents progresses on the fabrication technologies of ICF targets. The existing problem and the future needs of ICF target fabrication technologies are also discussed. (authors)

  8. Switching Fabric Based on Multi-Level LVDS Compatible Interconnect, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Switching fabric (SF) is the key component of the next generation of back plane interconnects. Low power, TID and SEU resistant and high bandwidth upgradeable...

  9. Fabrication of FORTIS

    Science.gov (United States)

    McCandliss, Stephan R.; Fleming, Brian; Kaiser, Mary Elizabeth; Kruk, Jeffrey; Feldman, Paul D.; Kutyrev, Alexander S.; Li, Mary J.; Goodwin, Phillip A.; Rapchun, David; Lyness, Eric; Brown, Ari D.; Moseley, Harvey; Siegmund, Oswald; Vallerga, John

    2010-07-01

    The Johns Hopkins University sounding rocket group is building the Far-ultraviolet Off Rowland-circle Telescope for Imaging and Spectroscopy (FORTIS), which is a Gregorian telescope with rulings on the secondary mirror. FORTIS will be launched on a sounding rocket from White Sand Missile Range to study the relationship between Lyman alpha escape and the local gas-to-dust ratio in star forming galaxies with non-zero redshifts. It is designed to acquire images of a 30' x 30' field and provide fully redundant "on-the-fly" spectral acquisition of 43 separate targets in the field with a bandpass of 900 - 1800 Angstroms. FORTIS is an enabling scientific and technical activity for future cutting edge far- and near-uv survey missions seeking to: search for Lyman continuum radiation leaking from star forming galaxies, determine the epoch of He II reionization and characterize baryon acoustic oscillations using the Lyman forest. In addition to the high efficiency "two bounce" dual-order spectro-telescope design, FORTIS incorporates a number of innovative technologies including: an image dissecting microshutter array developed by GSFC; a large area (~ 45 mm x 170 mm) microchannel plate detector with central imaging and "outrigger" spectral channels provided by Sensor Sciences; and an autonomous targeting microprocessor incorporating commercially available field programable gate arrays. We discuss progress to date in developing our pathfinder instrument.

  10. Fabrication of High Temperature Cermet Materials for Nuclear Thermal Propulsion

    Science.gov (United States)

    Hickman, Robert; Panda, Binayak; Shah, Sandeep

    2005-01-01

    Processing techniques are being developed to fabricate refractory metal and ceramic cermet materials for Nuclear Thermal Propulsion (NTP). Significant advances have been made in the area of high-temperature cermet fuel processing since RoverNERVA. Cermet materials offer several advantages such as retention of fission products and fuels, thermal shock resistance, hydrogen compatibility, high conductivity, and high strength. Recent NASA h d e d research has demonstrated the net shape fabrication of W-Re-HfC and other refractory metal and ceramic components that are similar to UN/W-Re cermet fuels. This effort is focused on basic research and characterization to identify the most promising compositions and processing techniques. A particular emphasis is being placed on low cost processes to fabricate near net shape parts of practical size. Several processing methods including Vacuum Plasma Spray (VPS) and conventional PM processes are being evaluated to fabricate material property samples and components. Surrogate W-Re/ZrN cermet fuel materials are being used to develop processing techniques for both coated and uncoated ceramic particles. After process optimization, depleted uranium-based cermets will be fabricated and tested to evaluate mechanical, thermal, and hot H2 erosion properties. This paper provides details on the current results of the project.

  11. Natural fabric of Hildegardia populifolia composites

    CSIR Research Space (South Africa)

    Guduri, BBR

    2006-12-01

    Full Text Available The influence of Hildegardia populofolia fabric content, fabric orientation, sodium hydroxide (NaOH) and silane coupling agent treatment on the surface properties of the fabric, mechanical and fracture properties of Hildegardia populifolia...

  12. Properties of natural fabric Polyalthia cerasoides

    CSIR Research Space (South Africa)

    Jayaramudu, J

    2009-06-01

    Full Text Available of this fabric were compared with those of two natural fabrics reported in the literature. This uniaxial fabric has sufficient tensile modulus and can be used as reinforcement in the development of green composites....

  13. LH2 Target Design & Position Survey Techniques for the MUSE experiment for Precise Proton Radius Measurement

    Science.gov (United States)

    Le Pottier, Luc; Roy, Pryiashee; Lorenzon, Wolfgang; Raymond, Richard; Steinberg, Noah; Rossi de La Fuente, Erick; MUSE (MUon proton Scattering Experiment) Collaboration

    2017-09-01

    The proton radius puzzle is a currently unresolved problem which has intrigued the scientific community, dealing with a 7 σ discrepancy between the proton radii determined from muonic hydrogen spectroscopy and electron scattering measurements. The MUon Scattering Experiment (MUSE) aims to resolve this puzzle by performing the first simultaneous elastic scattering measurements of both electrons and muons on the proton, which will allow the comparison of the radii from the two interactions with reduced systematic uncertainties. The data from this experiment is expected to provide the best test of lepton universality to date. The experiment will take place at the Paul Scherrer Institute in Switzerland in 2018. An essential component of the experiment is a liquid hydrogen (LH2) cryotarget system. Our group at the University of Michigan is responsible for the design, fabrication and installation of this system. Here we present our LH2 target cell design and fabrication techniques for successful operation at 20 K and 1 atm, and our computer vision-based target position survey system which will determine the position of the target, installed inside a vacuum chamber, with 0.01 mm or better precision at the height of the liquid hydrogen target and along the beam direction during the experiment.

  14. Assesment On The Possibility To Modify Fabrication Equipment For Fabrication Of HWR And LWR Fuel Elements

    International Nuclear Information System (INIS)

    Tri-Yulianto

    1996-01-01

    Based on TOR BATAN for PELITA VI. On of BATAN program in the fuel element production technology section is the acquisition of the fuel element fabrication technology for research reactor as well as power reactor. The acquisition can be achieved using different strategies, e.g. by utilizing the facility owned for research and development of the technology desired or by transferring the technology directly from the source. With regards to the above, PEBN through its facility in BEBE has started the acquisition of the fuel element fabrication technology for power reactor by developing the existing equipment initially designed to fabricate HWR Cinere fuel element. The development, by way of modifying the equipment, is intended for the production of HWR (Candu) and LWR (PWR and BWR) fuel elements. To achieve above objective, at the early stage of activity, an assesment on the fabrication equipment for pelletizing, component production and assembly. The assesment was made by comparing the shape and the size of the existing fuel element with those used in the operating reactors such as Candu reactors, PWR and BWR. Equipment having the potential to be modified for the production of HWR fuel elements are as followed: For the pelletizing equipment, the punch and dies can be used of the pressing machine for making green pellet can be modified so that different sizes of punch and dies can be used, depending upon the size of the HWR and LWR pellets. The equipment for component production has good potential for modification to produce the HWR Candu fuel element, which has similar shape and size with those of the existing fuel element, while the possibility of producing the LWR fuel element component is small because only a limited number of the required component can be made with the existing equipment. The assembly equipment has similar situation whit that of the component production, that is, to assemble the HWR fuel element modification of few assembly units very probable

  15. Topical report on a preconceptual design for the Spallation-Induced Lithium Conversion (SILC) target for the accelerator production of tritium (APT)

    International Nuclear Information System (INIS)

    Van Tuyle, G.J.; Cokinos, D.M.; Czajkowski, C.; Franz, E.M.; Kroeger, P.; Todosow, M.; Youngblood, R.; Zucker, M.

    1993-01-01

    The preconceptual design of the APT Li-Al target system, also referred to as the Spallation-Induced Lithium Conversion (SILC), target system, is summarized in this report. The system has been designed to produce a ''3/8 Goal'' quantity of tritium using the 200-mA, 1.0 GeV proton beam emerging from the LANL-designed LINAC. The SILC target system consists of a beam expander, a heavy-water-cooled lead spallation neutron source assembly surrounded by light-water-cooled Li-Al blankets, a target window, heat removal systems, and related safety systems. The preconceptual design of each of these major components is described. Descriptions are also provided for the target fabrication, tritium extraction, and waste-steam processes. Performance characteristics are presented and discussed

  16. Topical report on a preconceptual design for the Spallation-Induced Lithium Conversion (SILC) target for the accelerator production of tritium (APT)

    Energy Technology Data Exchange (ETDEWEB)

    Van Tuyle, G.J.; Cokinos, D.M.; Czajkowski, C.; Franz, E.M.; Kroeger, P.; Todosow, M.; Youngblood, R.; Zucker, M.

    1993-09-30

    The preconceptual design of the APT Li-Al target system, also referred to as the Spallation-Induced Lithium Conversion (SILC), target system, is summarized in this report. The system has been designed to produce a ``3/8 Goal`` quantity of tritium using the 200-mA, 1.0 GeV proton beam emerging from the LANL-designed LINAC. The SILC target system consists of a beam expander, a heavy-water-cooled lead spallation neutron source assembly surrounded by light-water-cooled Li-Al blankets, a target window, heat removal systems, and related safety systems. The preconceptual design of each of these major components is described. Descriptions are also provided for the target fabrication, tritium extraction, and waste-steam processes. Performance characteristics are presented and discussed.

  17. Tunable top-down fabrication and functional surface coating of single-crystal titanium dioxide nanostructures and nanoparticles

    Science.gov (United States)

    Ha, Seungkyu; Janissen, Richard; Ussembayev, Yera Ye.; van Oene, Maarten M.; Solano, Belen; Dekker, Nynke H.

    2016-05-01

    Titanium dioxide (TiO2) is a key component of diverse optical and electronic applications that exploit its exceptional material properties. In particular, the use of TiO2 in its single-crystalline phase can offer substantial advantages over its amorphous and polycrystalline phases for existing and yet-to-be-developed applications. However, the implementation of single-crystal TiO2 has been hampered by challenges in its fabrication and subsequent surface functionalization. Here, we introduce a novel top-down approach that allows for batch fabrication of uniform high-aspect-ratio single-crystal TiO2 nanostructures with targeted sidewall profiles. We complement our fabrication approach with a functionalization strategy that achieves dense, uniform, and area-selective coating with a variety of biomolecules. This allows us to fabricate single-crystal rutile TiO2 nanocylinders tethered with individual DNA molecules for use as force- and torque-transducers in an optical torque wrench. These developments provide the means for increased exploitation of the superior material properties of single-crystal TiO2 at the nanoscale.Titanium dioxide (TiO2) is a key component of diverse optical and electronic applications that exploit its exceptional material properties. In particular, the use of TiO2 in its single-crystalline phase can offer substantial advantages over its amorphous and polycrystalline phases for existing and yet-to-be-developed applications. However, the implementation of single-crystal TiO2 has been hampered by challenges in its fabrication and subsequent surface functionalization. Here, we introduce a novel top-down approach that allows for batch fabrication of uniform high-aspect-ratio single-crystal TiO2 nanostructures with targeted sidewall profiles. We complement our fabrication approach with a functionalization strategy that achieves dense, uniform, and area-selective coating with a variety of biomolecules. This allows us to fabricate single-crystal rutile

  18. Fabrication of integrated metallic MEMS devices

    DEFF Research Database (Denmark)

    Yalcinkaya, Arda Deniz; Ravnkilde, Jan Tue; Hansen, Ole

    2002-01-01

    A simple and complementary metal oxide semiconductor (CMOS) compatible fabrication technique for microelectromechanical (MEMS) devices is presented. The fabrication technology makes use of electroplated metal layers. Among the fabricated devices, high quality factor microresonators are characteri......A simple and complementary metal oxide semiconductor (CMOS) compatible fabrication technique for microelectromechanical (MEMS) devices is presented. The fabrication technology makes use of electroplated metal layers. Among the fabricated devices, high quality factor microresonators...

  19. Power plant production of inertial confinement fusion targets

    International Nuclear Information System (INIS)

    Hendricks, C.D.; Johnson, W.L.

    1979-01-01

    Many of the current techniques for fabricating experimental targets appear to be directly extendable to the high-rate, low-cost production of reactor targets. This report describes several new techniques that, in conjunction with the expansion of existing techniques, can constitute a target factory. We have evaluated this concept on the basis of a generalized reactor target design and the projected specifications of reactor-grade targets

  20. Mitigating component performance variation

    Science.gov (United States)

    Gara, Alan G.; Sylvester, Steve S.; Eastep, Jonathan M.; Nagappan, Ramkumar; Cantalupo, Christopher M.

    2018-01-09

    Apparatus and methods may provide for characterizing a plurality of similar components of a distributed computing system based on a maximum safe operation level associated with each component and storing characterization data in a database and allocating non-uniform power to each similar component based at least in part on the characterization data in the database to substantially equalize performance of the components.

  1. Pilling Resistance of Knitted Fabrics

    Directory of Open Access Journals (Sweden)

    Gita BUSILIENĖ

    2011-09-01

    Full Text Available Knitted fabrics with different quantity of elastane, conspicuous by high viscosity and elasticity, having one of the most important performance properties - resistance to pilling are often used in the production of high quality sportswear. During technological process imitating operating conditions, the behaviour of knitted fabrics may be changed by different industrial softeners from 12 % to 20 % of active substance, for example fatty acid condensate (Tubingal 5051 or silicone micro emulsion (Tubingal SMF. The aim of this investigation is to define the influence of fibrous composition and chemical softeners to the propensity of fuzzing and pilling of plain and plated jersey pattern knitted fabrics. The results of investigations showed that fibrous composition and thickness of materials (up to 6 % and washing as well as softening (from 33 % to 67 % change the resistance of knitted fabrics to pilling.http://dx.doi.org/10.5755/j01.ms.17.3.597

  2. Geoacoustic Physical Model Fabrication Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — FUNCTION: Fabricates three-dimensional rough surfaces (e.g., fractals, ripples) out of materials such as PVC or wax to simulate the roughness properties associated...

  3. New fabrication techniques for the nuclear fuels of tomorrow

    International Nuclear Information System (INIS)

    Babelot, J.F.; Bokelund, H.; Gerontopoulos, P.; Gueugnon, J.F.; Richter, K.

    1995-01-01

    The shift of the emphasis of the work at the Institute for Transuranium Elements (ITU) from the development of fuels based on uranium and plutonium to safety aspects concerning the use of plutonium and other of actinides, necessitates the production of targets containing appreciable amounts of minor actinides for irradiation experiments. The handling of minor actinides requires additional protective measures, combined with improved fuel fabrication techniques. The boundary conditions for a suitable process are flexibility, adaptability to remote control, and minimization of dust formation. A method based on the sol-gel fabrication technique meets these criteria, and was selected for the present developments at ITU. (author)

  4. Microencapsulation and fabrication of fuel pellets for inertial confinement fusion

    International Nuclear Information System (INIS)

    Nolen, R.L. Jr.; Kool, L.B.

    1981-01-01

    Various microencapsulation techniques were evaluated for fabrication of thermonuclear fuel pellets for use in existing experimental facilities studying inertial confinement fusion and in future fusion-power reactors. Coacervation, spray drying, in situ polymerization, and physical microencapsulation methods were employed. Highly spherical, hollow polymeric shells were fabricated ranging in size from 20 to 7000 micron. In situ polymerization microencapsulation with poly(methyl methacrylate) provided large shells, but problems with local wall defects still must be solved. Extension to other polymeric systems met with limited success. Requirements for inertial confinement fusion targets are described, as are the methods that were used

  5. Silicone nanocomposite coatings for fabrics

    Science.gov (United States)

    Eberts, Kenneth (Inventor); Lee, Stein S. (Inventor); Singhal, Amit (Inventor); Ou, Runqing (Inventor)

    2011-01-01

    A silicone based coating for fabrics utilizing dual nanocomposite fillers providing enhanced mechanical and thermal properties to the silicone base. The first filler includes nanoclusters of polydimethylsiloxane (PDMS) and a metal oxide and a second filler of exfoliated clay nanoparticles. The coating is particularly suitable for inflatable fabrics used in several space, military, and consumer applications, including airbags, parachutes, rafts, boat sails, and inflatable shelters.

  6. Safeguards through secure automated fabrication

    International Nuclear Information System (INIS)

    DeMerschman, A.W.; Carlson, R.L.

    1982-01-01

    Westinghouse Hanford Company, a prime contractor for the U.S. Department of Energy, is constructing the Secure Automated Fabrication (SAF) line for fabrication of mixed oxide breeder fuel pins. Fuel processing by automation, which provides a separation of personnel from fuel handling, will provide a means whereby advanced safeguards concepts will be introduced. Remote operations and the inter-tie between the process computer and the safeguards computer are discussed

  7. Targeted Learning

    CERN Document Server

    van der Laan, Mark J

    2011-01-01

    The statistics profession is at a unique point in history. The need for valid statistical tools is greater than ever; data sets are massive, often measuring hundreds of thousands of measurements for a single subject. The field is ready to move towards clear objective benchmarks under which tools can be evaluated. Targeted learning allows (1) the full generalization and utilization of cross-validation as an estimator selection tool so that the subjective choices made by humans are now made by the machine, and (2) targeting the fitting of the probability distribution of the data toward the targe

  8. Target preparation

    International Nuclear Information System (INIS)

    Hinn, G.M.

    1984-01-01

    A few of the more interesting of the 210 targets prepared in the Laboratory last year are listed. In addition the author continues to use powdered silver mixed with /sup 9,10/BeO to produce sources for accelerator radio dating of Alaskan and South Polar snow. Currently, he is trying to increase production by multiple sample processing. Also the author routinely makes 3 μg/cm 2 cracked slacked carbon stripper foils and is continuing research with some degree of success in making enriched 28 Si targets starting with the oxide

  9. IPRDS: component histories and nuclear plant aging

    International Nuclear Information System (INIS)

    Borkowski, R.J.; Kahl, W.K.

    1984-01-01

    A comprehensive assessment of nuclear power plant component operating histories, maintenance histories, and design and fabrication details is essential to understanding aging phenomena. As part of the In-Plant Reliability Data System (IPRDS), an attempt is being made to collect and analyze such information from a sampling of US nuclear power plants. Utilizing the IPRDS, one can reconstruct the failure history of the components and gain new insight into the causes and modes of failures resulting from normal or premature aging. This information assembled from the IPRDS can be combined with operating histories and postservice component inspection results for cradle-to-grave assessments of component aging under operating conditions. A comprehensive aging assessment can then be used to provide guidelines for improving the detection, monitoring, and mitigation of aging-related failures

  10. Integrating 3D CAD data for manufacturing and fabrication the core model of reactor TRIGA PUSPATI

    International Nuclear Information System (INIS)

    Abu Bakar Harun

    2005-01-01

    This paper describe the intrigue integration of digital 3 Dimensional Computer Aided Design (3D CAD) data manipulation for the Core Model fabrication of REAKTOR TRIGA PUSPATI and ready for mass manufacturing. 3 Dimensional CAD data from Computer Aided Design program will be used as an interpreter in the fabrication of this project. The Core Model of REAKTOR TRIGA PUSPATI will be fabricated with the aid of 3D CAD drawings and digital files. The components will be segregated and divided into 2 categories namely Conventional d Rapid Fabrication. (Author)

  11. Design and Testing of Improved Spacesuit Shielding Components

    International Nuclear Information System (INIS)

    Ware, J.; Ferl, J.; Wilson, J.W.; Clowdsley, M.S.; DeAngelis, G.; Tweed, J.; Zeitlin, C.J.

    2002-01-01

    In prior studies of the current Shuttle Spacesuit (SSA), where basic fabric lay-ups were tested for shielding capabilities, it was found that the fabric portions of the suit give far less protection than previously estimated due to porosity and non-uniformity of fabric and LCVG components. In addition, overall material transmission properties were less than optimum. A number of alternate approaches are being tested to provide more uniform coverage and to use more efficient materials. We will discuss in this paper, recent testing of new material lay-ups/configurations for possible use in future spacesuit designs

  12. Advances in modeling of chemical vapor infiltration for tube fabrication

    Energy Technology Data Exchange (ETDEWEB)

    Starr, T.L. [Georgia Inst. of Tech., Atlanta, GA (United States). School of Materials Science and Technology

    1998-04-01

    The forced flow/thermal gradient chemical vapor infiltration process (FCVI) can be used for fabrication of tube-shaped components of ceramic matrix composites. Recent experimental work at Oak Ridge National Laboratory (ORNL) includes process and materials development studies using a small tube reactor. Use of FCVI for this geometry involves significant changes in fixturing as compared to disk-shaped preforms previously fabricated. The authors have used their computer model of the CVI process to simulate tube densification and to identify process modifications that will decrease processing time. This report presents recent model developments and applications.

  13. Additive Manufacturing of Molds for Fabrication of Insulated Concrete Block

    Energy Technology Data Exchange (ETDEWEB)

    Love, Lonnie J. [ORNL; Lloyd, Peter D. [ORNL

    2018-02-01

    ORNL worked with concrete block manufacturer, NRG Insulated Block, to demonstrate additive manufacturing of a multi-component block mold for its line of insulated blocks. Solid models of the mold parts were constructed from existing two-dimensional drawings and the parts were fabricated on a Stratasys Fortus 900 using ULTEM 9085. Block mold parts were delivered to NRG and installed on one of their fabrication lines. While form and fit were acceptable, the molds failed to function during NRG’s testing.

  14. Design and Fabrication of the Lithium Beam Ion Injector for NDCX-II

    International Nuclear Information System (INIS)

    Takakuwa, J.

    2011-01-01

    A 130 keV injector is developed for the NDCX-II facility. It consists of a 10.9 cm diameter lithium doped alumina-silicate ion source heated to ∼1300 C and 3 electrodes. Other components include a segmented Rogowski coil for current and beam position monitoring, a gate valve, pumping ports, a focusing solenoid, a steering coil and space for inspection and maintenance access. Significant design challenges including managing the 3-4 kW of power dissipation from the source heater, temperature uniformity across the emitter surface, quick access for frequent ion source replacement, mechanical alignment with tight tolerance, and structural stabilization of the cantilevered 27-inch OD graded HV ceramic column. The injector fabrication is scheduled to complete by May 2011, and assembly and installation is scheduled to complete by the beginning of July. The Neutralized Drift Compression eXperiment (NDCX-II) is for the study of high energy density physics and inertial fusion energy research utilizing a lithium ion (Li+) beam with a current of 93 mA and a pulse length of 500 ns (compressed to 1 ns at the target). The injector is one of the most complicated sections of the NDCX-II accelerator demanding significant design and fabrication resources. It needs to accommodate a relatively large ion source (10.9 cm), a high heat load (3-4 kW) and specific beam optics developed from the physics model. Some specific design challenges are noted in this paper.

  15. The ISIS target

    International Nuclear Information System (INIS)

    Carne, A.; Broome, T.A.; Hogston, J.R.; Holding, M.

    1989-01-01

    This presentation discusses the two target failures that have occurred, gives the understanding of the causes and indicates the steps being taken to alleviate the problems. At the outset of the design it was understood that the target would have a finite lifetime, due to radiation damage effects, exacerbated by mechanical damage due to thermal cycling and fatigue. Estimates of target lifetime at full intensity are about 2 years for radiation damage swelling and about 10E4 gross thermal excursions. The latter number is the one which gives uncertainty in defining the life of the target, since it is dependent on the reliability of the accelerator and quality of the proton beam. The commissioning of an accelerator system and bringing it up to high beam intensities have their own special problems. There must be protection of components against uncontrolled beam loss, which produces thermal damage, prompt radiation and induced activity. Fast beam trips for beam loss protection, or equipment failures, result in quenches from high temperature in the target which get bigger with increasing beam intensity. But the target itself is a difficult device to make, taking about 12 months to manufacture. Further, changing one is a complex and time consuming task, not without its hazards. There is thus something of a balancing act to bring the accelerator towards specification before the target fails due to thermal cycling fatigue. In the early days of ISIS beam loss protection was the dominant consideration and the target was regarded somewhat as a sacrificial lamb to the goddess of machine reliability. 2 refs., 6 figs

  16. Target imaging and backlighting diagnosis

    International Nuclear Information System (INIS)

    Yaakobi, B.; Shvarts, D.; Marshall, F.J.; Epstein, R.; Su, Q.

    1995-01-01

    The expected backlighting and self-emission images of a particular CH target to be imploded on the Omega Upgrade are calculated for a variety of experimental parameters. It is shown that to overcome the problem of target self-emission, the image has to be monochromatized with a diffracting crystal. For the target studied, the two image components are then comparable in intensity and both provide useful information on target behavior. A particularly interesting feature is the appearance in the self-emission of a circular spike which closely delineates the fuel-shell interface, but requires high spatial resolution to be observed

  17. 3D-printed optical active components

    Science.gov (United States)

    Suresh Nair, S.; Nuding, J.; Heinrich, A.

    2018-02-01

    Additive Manufacturing (AM) has the potential to become a powerful tool in the realization of complex optical components. The primary advantage that meets the eye, is that fabrication of geometrically complicated optical structures is made easier in AM as compared to the conventional fabrication methods (using molds for instance). But this is not the only degree of freedom that AM has to offer. With the multitude of materials suitable for AM in the market, it is possible to introduce functionality into the components one step before fabrication: by altering the raw material. A passive example would be to use materials with varying properties together, in a single manufacturing step, constructing samples with localized refractive indices for instance. An active approach is to blend in materials with distinct properties into the photopolymer resin and manufacturing with this composite material. Our research is currently focused in this direction, with the desired optical property to be introduced being Photoluminescence. Formation of nanocomposite mixtures to produce samples is the current approach. With this endeavor, new sensor systems can be realized, which may be used to measure the absorption spectra of biological samples. Thereby the sample compartment, the optics and the spectral light source (different quantum dots) are 3D-printed in one run. This component can be individually adapted to the biological sample with respect to wavelength, optical and mechanical properties. Here we would like to present our work on the additive manufacturing of an active optical component. Based on the stereolithography method, a monolithic optical component was 3D-printed, showing light emission at different defined wavelengths due to UV excited quantum dots inside the 3D-printed optics.

  18. Improved Fabrication of Ceramic Matrix Composite/Foam Core Integrated Structures

    Science.gov (United States)

    Hurwitz, Frances I.

    2009-01-01

    The use of hybridized carbon/silicon carbide (C/SiC) fabric to reinforce ceramic matrix composite face sheets and the integration of such face sheets with a foam core creates a sandwich structure capable of withstanding high-heatflux environments (150 W/cm2) in which the core provides a temperature drop of 1,000 C between the surface and the back face without cracking or delamination of the structure. The composite face sheet exhibits a bilinear response, which results from the SiC matrix not being cracked on fabrication. In addition, the structure exhibits damage tolerance under impact with projectiles, showing no penetration to the back face sheet. These attributes make the composite ideal for leading edge structures and control surfaces in aerospace vehicles, as well as for acreage thermal protection systems and in high-temperature, lightweight stiffened structures. By tailoring the coefficient of thermal expansion (CTE) of a carbon fiber containing ceramic matrix composite (CMC) face sheet to match that of a ceramic foam core, the face sheet and the core can be integrally fabricated without any delamination. Carbon and SiC are woven together in the reinforcing fabric. Integral densification of the CMC and the foam core is accomplished with chemical vapor deposition, eliminating the need for bond-line adhesive. This means there is no need to separately fabricate the core and the face sheet, or to bond the two elements together, risking edge delamination during use. Fibers of two or more types are woven together on a loom. The carbon and ceramic fibers are pulled into the same pick location during the weaving process. Tow spacing may be varied to accommodate the increased volume of the combined fiber tows while maintaining a target fiber volume fraction in the composite. Foam pore size, strut thickness, and ratio of face sheet to core thickness can be used to tailor thermal and mechanical properties. The anticipated CTE for the hybridized composite is managed by

  19. Quartz crystal fabrication facility

    Science.gov (United States)

    Ney, R. J.

    1980-05-01

    The report describes the design and operation of a five chamber, interconnected vacuum system, which is capable of cleaning, plating, and sealing precision quartz crystal units in ceramic flatpack enclosures continuously in a high vacuum environment. The production rate design goal was 200 units per eight hour day. A unique nozzle beam gold deposition source was developed to operate for extended periods of time without reloading. The source puts out a narrow beam of gold typically in the order of 2 1/2 deg included cone angle. Maximum deposition rates are in the order of 400 a/min at 5.5 in. 'throw' distance used. Entrance and exit air lock chambers expedite the material throughput, so that the processing chambers are at high vacuum for extended periods of time. A stainless steel conveyor belt, in conjunction with three vacuum manipulators, transport the resonator components to the various work stations. Individual chambers are normally separated from each other by gate valves. The crystal resonators, mounted in flatpack frames but unplated, are loaded into transport trays in a lid-frame-lid sequency for insertion into the system and exit as completed crystal units. The system utilizes molybdenum coated ball bearings at essentially all friction surfaces. The gold sources and plating mask heads are equipped with elevators and gate valves, so that they can be removed from the system for maintenance without exposing the chambers to atmosphere.

  20. Laser-based target tracking using principal component descriptors

    CSIR Research Space (South Africa)

    Burke, Michael G

    2010-11-01

    Full Text Available scans are pre-filtered using a median filter, in order to remove salt and pepper noise. Thereafter, scans are divided into segments through jump-distance classification. This in- volves a simple pass over the laser data, separating segments...