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Sample records for tarbimine vib tsta

  1. Visuaalkultuur ja tarbimine / Rael Artel

    Index Scriptorium Estoniae

    Artel, Rael, 1980-

    2001-01-01

    Helsingis toimunud Soome AICA sektsiooni korraldatud rahvusvahelisest Põhja- ja Baltimaade konverentsist, mille teemaks tarbimine ja kunsti uued tehnoloogiad. Viini Kunstiakadeemia rektori Boris Groysi, inglise kunstiteadlase Patricia Bickersi ja soome kuraatori Susanna Pettersoni ettekannetest.

  2. The blanket interface to TSTA

    International Nuclear Information System (INIS)

    Clemmer, R.G.; Finn, P.A.; Grimm, T.L.; Sze, D.K.; Anderson, J.L.; Bartlit, J.R.; Naruse, Y.; Yoshida, H.

    1988-01-01

    The requirements of tritium technology are centered in three main areas, (1) fuel processing, (2) breeder tritium extraction, and (3) tritium containment. The Tritium Systems Test Assembly (TSTA) now in operation at Los Alamos National Laboratory (LANL) is dedicated to developing and demonstrating the tritium technology for fuel processing and containment. TSTA is the only fusion fuel processing facility that can operate in a continuous closed-loop mode. The tritium throughput of TSTA is 1000 g/d. However, TSTA does not have a blanket interface system. The authors have initiated a study to define a Breeder Blanket Interface (BBIO) for TSTA. The first step of the work is to define the condition of the gaseous tritium stream from the blanket tritium recovery system. This report summarizes this part of the work for one particular blanket concept, i.e., a self-cooled lithium blanket. The total gas throughput, the hydrogen to tritium ratio, the corrosive chemicals, and the radionuclides are defined. Various methods of tritium recovery from liquid lithium were assessed: yttrium gettering, permeation windows, and molten salt extraction. The authors' evaluation concluded that the best method was molten salt extraction

  3. System support software for TSTA

    International Nuclear Information System (INIS)

    Claborn, G.W.; Mann, L.W.; Nielson, C.W.

    1987-01-01

    The software at the Tritium Systems Test Assembly (TSTA) is logically broken into two parts, the system support software and the subsystem software. The purpose of the system support software is to isolate the subsystem software from the physical hardware. In this sense the system support software forms the kernel of the software at TSTA. The kernel software performs several functions. It gathers data from CAMAC modules and makes that data available for subsystem processes. It services requests to send commands to CAMAC modules. It provides a system of logging functions and provides for a system-wide global program state that allows highly structured interaction between subsystem processes. The kernel's most visible function is to provide the Man-Machine Interface (MMI). The MMI allows the operators a window into the physical hardware and subsystem process state. Finally the kernel provides a data archiving and compression function that allows archival data to be accessed and plotted. Such kernel software as developed and implemented at TSTA is described

  4. Tritium handling and processing experience at TSTA

    International Nuclear Information System (INIS)

    Anderson, J.L.; Okuno, K.

    1994-01-01

    In 1987, the Japan Atomic Energy Research Institute (JAERI) and the US Department of Energy (DOE) signed a collaborative agreement (Annex IV) for the joint funding and operation of the Tritium Systems Test Assembly (TSTA) at the Los Alamos National Laboratory (LANL) for a five year period ending June, 1992. After this initial five year collaboration, the Annex IV agreement was extended for another two year period ending June, 1994. During the first five years, a number of the integrated process loop tests of TSTA were conducted, as well as off-line testing of TSTA subsystems. During integrated loop testing the vacuum system, fuel cleanup systems, isotope separation system, transfer pumping system and gas analysis system, are interconnected and tested using 100 g-inventories of tritium to demonstrate steady-state operation of a tritium fuel processing cycle for a fusion reactor. These tests have resulted in a number of significant accomplishments and an experience data base on research, development and operation of the fuel processing system. One of the most significant accomplishments during the initial five year period was the continuous operation of the fuel processing loop for 25 days. During this 25-day extended operation, both the JAERI fuel cleanup system (J-FCU) and the original TSTA fuel cleanup system (FCU) were operated under similar conditions of flow, pressure, and impurity content of the DT gas. Both fuel cleanup systems were demonstrated to provide adequate impurity removal for plasma exhaust gas processing. The isotope separation system was operated continuously, producing pure tritium while rejecting protium as an impurity

  5. TSTA Piping and Flame Arrestor Operating Experience Data

    Energy Technology Data Exchange (ETDEWEB)

    Cadwallader, Lee C.; Willms, R. Scott

    2014-10-01

    The Tritium Systems Test Assembly (TSTA) was a facility dedicated to tritium handling technology and experiment research at the Los Alamos National Laboratory. The facility operated from 1984 to 2001, running a prototype fusion fuel processing loop with ~100 grams of tritium as well as small experiments. There have been several operating experience reports written on this facility’s operation and maintenance experience. This paper describes analysis of two additional components from TSTA, small diameter gas piping that handled small amounts of tritium in a nitrogen carrier gas, and the flame arrestor used in this piping system. The operating experiences and the component failure rates for these components are discussed in this paper. Comparison data from other applications are also presented.

  6. Subsystem software for TSTA [Tritium Systems Test Assembly

    International Nuclear Information System (INIS)

    Mann, L.W.; Claborn, G.W.; Nielson, C.W.

    1987-01-01

    The Subsystem Control Software at the Tritium System Test Assembly (TSTA) must control sophisticated chemical processes through the physical operation of valves, motor controllers, gas sampling devices, thermocouples, pressure transducers, and similar devices. Such control software has to be capable of passing stringent quality assurance (QA) criteria to provide for the safe handling of significant amounts of tritium on a routine basis. Since many of the chemical processes and physical components are experimental, the control software has to be flexible enough to allow for trial/error learning curve, but still protect the environment and personnel from exposure to unsafe levels of radiation. The software at TSTA is implemented in several levels as described in a preceding paper in these proceedings. This paper depends on information given in the preceding paper for understanding. The top level is the Subsystem Control level

  7. System support software for TSTA [Tritium Systems Test Assembly

    International Nuclear Information System (INIS)

    Claborn, G.W.; Mann, L.W.; Nielson, C.W.

    1987-10-01

    The fact that Tritium Systems Test Assembly (TSTA) is an experimental facility makes it impossible and undesirable to try to forecast the exact software requirements. Thus the software had to be written in a manner that would allow modifications without compromising the safety requirements imposed by the handling of tritium. This suggested a multi-level approach to the software. In this approach (much like the ISO network model) each level is isolated from the level below and above by cleanly defined interfaces. For example, the subsystem support level interfaces with the subsystem hardware through the software support level. Routines in the software support level provide operations like ''OPEN VALVE'' and CLOSE VALVE'' to the subsystem level. This isolates the subsystem level from the actual hardware. This is advantageous because changes can occur in any level without the need for propagating the change to any other level. The TSTA control system consists of the hardware level, the data conversion level, the operator interface level, and the subsystem process level. These levels are described

  8. Single column and two-column H-D-T distillation experiments at TSTA

    International Nuclear Information System (INIS)

    Yamanishi, T.; Yoshida, H.; Hirata, S.; Naito, T.; Naruse, Y.; Sherman, R.H.; Bartlit, J.R.; Anderson, J.L.

    1988-01-01

    Cryogenic distillation experiments were peformed at TSTA with H-D-T system by using a single column and a two-column cascade. In the single column experiment, fundamental engineering data such as the liquid holdup and the HETP were measured under a variety of operational condtions. The liquid holdup in the packed section was about 10 /approximately/ 15% of its superficial volume. The HETP values were from 4 to 6 cm, and increased slightly with the vapor velocity. The reflux ratio had no effect on the HETP. For the wo-colunn experiemnt, dynamic behavior of the cascade was observed. 8 refs., 7 figs., 2 tabs

  9. Isolation of cDNAs encoding subunit VIb of cytochrome c oxidase and steady-state levels of coxVIb mRNA in different tissues

    NARCIS (Netherlands)

    Taanman, J. W.; Schrage, C.; Ponne, N. J.; Das, A. T.; Bolhuis, P. A.; de Vries, H.; Agsteribbe, E.

    1990-01-01

    A full-length cDNA clone specifying the nuclear-encoded subunit VIb of human cytochrome c oxidase (COX) was isolated from a human skeletal muscle cDNA expression library. This was done with antiserum directed against the group of subunits VIa, b and c of bovine heart COX. A potential

  10. Orexin-dependent activation of layer VIb enhances cortical network activity and integration of non-specific thalamocortical inputs.

    Science.gov (United States)

    Hay, Y Audrey; Andjelic, Sofija; Badr, Sammy; Lambolez, Bertrand

    2015-11-01

    Neocortical layer VI is critically involved in thalamocortical activity changes during the sleep/wake cycle. It receives dense projections from thalamic nuclei sensitive to the wake-promoting neuropeptides orexins, and its deepest part, layer VIb, is the only cortical lamina reactive to orexins. This convergence of wake-promoting inputs prompted us to investigate how layer VIb can modulate cortical arousal, using patch-clamp recordings and optogenetics in rat brain slices. We found that the majority of layer VIb neurons were excited by nicotinic agonists and orexin through the activation of nicotinic receptors containing α4-α5-β2 subunits and OX2 receptor, respectively. Specific effects of orexin on layer VIb neurons were potentiated by low nicotine concentrations and we used this paradigm to explore their intracortical projections. Co-application of nicotine and orexin increased the frequency of excitatory post-synaptic currents in the ipsilateral cortex, with maximal effect in infragranular layers and minimal effect in layer IV, as well as in the contralateral cortex. The ability of layer VIb to relay thalamocortical inputs was tested using photostimulation of channelrhodopsin-expressing fibers from the orexin-sensitive rhomboid nucleus in the parietal cortex. Photostimulation induced robust excitatory currents in layer VIa neurons that were not pre-synaptically modulated by orexin, but exhibited a delayed, orexin-dependent, component. Activation of layer VIb by orexin enhanced the reliability and spike-timing precision of layer VIa responses to rhomboid inputs. These results indicate that layer VIb acts as an orexin-gated excitatory feedforward loop that potentiates thalamocortical arousal.

  11. Carbide-forming groups IVB-VIB metals: a new territory in the periodic table for CVD growth of graphene.

    Science.gov (United States)

    Zou, Zhiyu; Fu, Lei; Song, Xiuju; Zhang, Yanfeng; Liu, Zhongfan

    2014-07-09

    Early transition metals, especially groups IVB-VIB metals, can form stable carbides, which are known to exhibit excellent "noble-metal-like" catalytic activities. We demonstrate herein the applications of groups IVB-VIB metals in graphene growth using atmospheric pressure chemical vapor deposition technique. Similar to the extensively studied Cu, Ni, and noble metals, these transition-metal foils facilitate the catalytic growth of single- to few-layer graphene. The most attractive advantage over the existing catalysts is their perfect control of layer thickness and uniformity with highly flexible experimental conditions by in situ converting the dissolved carbons into stable carbides to fully suppress the upward segregation/precipitation effect. The growth performance of graphene on these transition metals can be well explained by the periodic physicochemical properties of elements. Our work has disclosed a new territory of catalysts in the periodic table for graphene growth and is expected to trigger more interest in graphene research.

  12. Crystallization and preliminary X-ray crystallographic studies of VibE, a vibriobactin-specific 2,3-dihydroxybenzoate-AMP ligase from Vibrio cholerae

    International Nuclear Information System (INIS)

    Liu, Xiuhua; Wang, Zhi; Zhu, Deyu; Wei, Tiandi; Gu, Lichuan; Xu, Sujuan

    2011-01-01

    This article reports the molecular cloning, protein expression and purification, crystallization and preliminary X-ray crystallographic analysis of the vibriobactin synthetase VibE from V. cholerae. Vibriobactin synthetases (VibABCDEFH) catalyze the biosynthesis of vibriobactin in the pathogenic bacterium Vibrio cholerae. VibE, a vibriobactin-specific 2,3-dihydroxybenzoate-AMP ligase, plays a critical role in the transfer of 2,3-dihydroxybenzoate to the aryl carrier protein domain of holo VibB. Here, the cloning, protein expression and purification, crystallization and preliminary X-ray crystallographic analysis of VibE from V. cholerae are reported. The VibE crystal diffracted to 2.3 Å resolution. The crystal belonged to space group P2 1 , with unit-cell parameters a = 56.471, b = 45.927, c = 77.014 Å, β = 95.895°. There is one protein molecule in the asymmetric unit, with a corresponding Matthews coefficient of 1.63 Å 3 Da −1 and solvent content of 24.41%

  13. Vib--rotational energy distributions and relaxation processes in pulsed HF chemical lasers

    International Nuclear Information System (INIS)

    Ben-Shaul, A.; Kompa, K.L.; Schmailzl, U.

    1976-01-01

    The rate equations governing the temporal evolution of photon densities and level populations in pulsed F+H 2 →HF+H chemical lasers are solved for different initial conditions. The rate equations are solved simultaneously for all relevant vibrational--rotational levels and vibrational--rotational P-branch transitions. Rotational equilibrium is not assumed. Approximate expressions for the detailed state-to-state rate constants corresponding to the various energy transfer processes (V--V, V--R,T, R--R,T) coupling the vib--rotational levels are formulated on the basis of experimental data, approximate theories, and qualitative considerations. The main findings are as follows: At low pressures, R--T transfer cannot compete with the stimulated emission, and the laser output largely reflects the nonequilibrium energy distribution in the pumping reaction. The various transitions reach threshold and decay almost independently and simultaneous lasing on several lines takes place. When a buffer gas is added in excess to the reacting mixture, the enhanced rotational relaxation leads to nearly single-line operation and to the J shift in lasing. Laser efficiency is higher at high inert gas pressures owing to a better extraction of the internal energy from partially inverted populations. V--V exchange enhances lasing from upper vibrational levels but reduces the total pulse intensity. V--R,T processes reduce the efficiency but do not substantially modify the spectral output distribution. The photon yield ranges between 0.4 and 1.4 photons/HF molecule depending on the initial conditions. Comparison with experimental data, when available, is fair

  14. Electrochemistry of vanadocene dichloride in tetrahydrofuran and general scheme of the electroreduction of metallocene dichlorides of subgroups IVB-VIB

    Energy Technology Data Exchange (ETDEWEB)

    Kuzharenko, S.V.; Strelets, V.V.

    1987-08-10

    In tetrahydrofuran medium on a dropping mercury electrode, vanadocene dichloride undergoes reversible one-electron reduction to a metastable vanadocene dichloride anion on the first wave; this anion is reversibly dehalogenated in the layer near the electrode, forming vanadocene monochloride. On the second wave there is an irreversible one-electron reduction of vanadocene monochloride to vanadocene. The reversible one-electron reduction of vanadocene on the third wave leads to the formation of metastable anion Cp/sub 2/V/sup -/ as the primary product. A general scheme is proposed for the electroreduction of metallocene dichlorides of subgroups IVB-VIB.

  15. Tissue-specific transplantation antigen P35B (TSTA3) immune response-mediated metabolism coupling cell cycle to postreplication repair network in no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection) by biocomputation.

    Science.gov (United States)

    Wang, Lin; Huang, Juxiang; Jiang, Minghu; Lin, Hong

    2012-06-01

    We constructed the low-expression tissue-specific transplantation antigen P35B (TSTA3) immune response-mediated metabolism coupling cell cycle to postreplication repair network in no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection) compared with high-expression (fold change ≥ 2) human hepatocellular carcinoma in GEO data set, by using integration of gene regulatory network inference method with gene ontology analysis of TSTA3-activated up- and downstream networks. Our results showed TSTA3 upstream-activated CCNB2, CKS1B, ELAVL3, GAS7, NQO1, NTN1, OCRL, PLA2G1B, REG3A, SSTR5, etc. and TSTA3 downstream-activated BAP1, BRCA1, CCL20, MCM2, MS4A2, NTN1, REG1A, TP53I11, VCAN, SLC16A3, etc. in no-tumor hepatitis/cirrhotic tissues. TSTA3-activated network enhanced the regulation of apoptosis, cyclin-dependent protein kinase activity, cell migration, insulin secretion, transcription, cell division, cell proliferation, DNA replication, postreplication repair, cell differentiation, T-cell homeostasis, neutrophil-mediated immunity, neutrophil chemotaxis, interleukin-8 production, inflammatory response, immune response, B-cell activation, humoral immune response, actin filament organization, xenobiotic metabolism, lipid metabolism, phospholipid metabolism, leukotriene biosynthesis, organismal lipid catabolism, phosphatidylcholine metabolism, arachidonic acid secretion, activation of phospholipase A2, deoxyribonucleotide biosynthesis, heterophilic cell adhesion, activation of MAPK activity, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, G-protein-coupled receptor protein signaling pathway, response to toxin, acute-phase response, DNA damage response, intercellular junction assembly, cell communication, and cell recognition, as a result of inducing immune response-mediated metabolism coupling cell cycle to postreplication repair in no-tumor hepatitis/cirrhotic tissues.

  16. Causes of the different catalytic activity of metallocene dichlorides of subgroups IVB-VIB in the amalgam reduction of carbon monoxide

    Energy Technology Data Exchange (ETDEWEB)

    Strelets, V.V.; Kuzharenko, S.V.; Tsarev, V.N.

    1987-08-10

    Vanadocene, generated by the amalgam reduction of Cp/sub 2/VCl/sub 2/ (Cp = eta/sup 5/-C/sub 5/H/sub 5/) in a medium of aprotic solvents (DMFA, THF, dimethylacetamide, DMSO, etc.), containing phenol as a proton donor, effectively catalyzes the reduction of CO by sodium amalgam at approx. 20/sup 0/C and 1 atm with the formation of C/sub 1/-C/sub 4/ hydrocarbons. In this work they studied the catalytic activity of other complexes of metals of subgroups IVB-VIB (M = Ti, Nb, Mo, W) in the amalgam reduction of CO in THF and DMFA medium. Differences in the catalytic activity of metallocene dichlorides of subgroups IVB-VIB in the amalgam reduction of carbon monoxide are due to thermodynamic factors determining the impossibility of amalgam reduction of the catalyst-substrate complex (subgroup IV) and differences in the stability of the corresponding metallocene (subgroups VB and VIB). Amalgam reduction of carbon monoxide, bound in a complex with metallocene, occurs under conditions of transfer of the first electron against the potential gradient.

  17. Majanduse aluseks on tarbimine / Kristo Reinsalu

    Index Scriptorium Estoniae

    Reinsalu, Kristo

    2001-01-01

    Ilmunud ka: Meie Maa, 24. okt. 2001, lk. 5; Harjumaa, 26. okt. 2001, lk. 5; Valgamaalane, 30. okt. 2001, lk. 6; Vooremaa, 1. nov. 2001, lk. 3; Hiiu Leht : Käina Kuller, 9. nov. 2001, lk. 3; Järva Teataja, 23. nov. 2001, lk. 2. Sularahanõudluse kasvutempode aeglustamisele aitab kaasa ka eraisikute tarbimiskulutuste katmine. Krediitkaartide populaarsuse kasv

  18. Linnuliha tootmine ja tarbimine on tõusuteel / Matti Piirsalu

    Index Scriptorium Estoniae

    Piirsalu, Matti, 1947-

    2004-01-01

    2004. a. III kvartali tootmistulemuste põhjal moodustab linnuliha osatähtsus kogu lihatoodangust 22%. Diagramm: Linnuliha kogutoodang Eestis. Tabelid: Linnuliha import Eestisse; Linnuliha ja linnulihatoodete bilanss (tuhat tonni)

  19. Leibkonna kulutused ja tarbimine = Household expenditure and consumption / Mari Kreitzberg

    Index Scriptorium Estoniae

    Kreitzberg, Mari

    2004-01-01

    Statistikaameti andmeid leibkondade 1996-2003. a. kulutuste suuruse, dünaamika; tarbimiskulutuste struktuuri, erinevuste kohta maal ja linnas; tarbimiskulutused maakonniti. Diagrammid. Tabelid. Graafikud

  20. Leibkonna kulutused ja tarbimine = Household expenditure and consumption / Mari Kreitzberg

    Index Scriptorium Estoniae

    Kreitzberg, Mari

    2005-01-01

    2004. aastal kulutas leibkonnaliige kuus keskmiselt 2799 krooni. Aastatel 1996-2004 suurenesid leibkonnaliikme keskmised kulutused kuus kuni 1,96 korda. Lisatud võrdlustabel leibkonnaliikme tarbimiskulutuste kohta Lätis ja Leedus 2004. a. Graafikud. Diagrammid. Tabelid

  1. Aids röövib miljoneid elusid / Merit Kopli

    Index Scriptorium Estoniae

    Kopli, Merit, 1969-

    2001-01-01

    ÜRO Aidsiprogrammi (UN-AIDS) ja Maailma Tervishoiuorganisatsiooni eile avaldatud aastaaruandest selgub, et aasta jooksul on maailmas registreeritud umbes viis miljonit uut nakatunut ehk iga päev saab viiruse 14 000 inimest

  2. Maxima: tarbimine elavneb alles kahe aasta pärast / Andres Reimer

    Index Scriptorium Estoniae

    Reimer, Andres

    2009-01-01

    Maxima grupi laienemine on peatatud, sh. ka Eestis. Maxima kaupluste arv vähenes Leedus kümne võrra, Eestis lisandus üks Maxima kauplus, Lätis jäi nende arv samaks. Prisma Peremarketi juhi Janne Tapio Lihavaineni hinnangul on Maxima poed liiga väikesed, et majanduskriisi ajal konkureerida

  3. Kas valitsuse tarbimine mõjutab eratarbimist? / Lenno Uusküla

    Index Scriptorium Estoniae

    Uusküla, Lenno

    2004-01-01

    Ilmunud ka: Kroon & Economy, nr. 3, 2004, lk. 5-16. Tarbimisfunktsioonidest, Ricardo samasuse teoreetilistest aspektidest, tarbe- ja kestvuskaupade olemusest, likviidsuspiirangutest, Ricardo samasusest Eestis. Graafikud. Tabelid

  4. Leibkonna kulutused ja tarbimine = Expenditure and consumption of a household / Mari Kreitzberg

    Index Scriptorium Estoniae

    Kreitzberg, Mari

    2006-01-01

    Leibkonna kulutusi ja nende struktuuri käsitletakse leibkonnaliikme kohta, vaatluse all on aastad 1996-2005. 2005. aastal olid leibkonnaliikme kuu keskmised kulutused 3189 krooni. Aastatel 1996-2005 suurenesid leibkonnaliikme keskmised kulutused kuus 2,23 korda, 1996. a. ostujõudu arvestades 1,45 korda. Diagrammid. Tabelid

  5. Teraviljatoodete tootmine, tarbimine ja kaubandus : [1994-2004 Eestis] / Taavi Kuntu

    Index Scriptorium Estoniae

    Kuntu, Taavi

    2005-01-01

    Ilmunud ka: Agriculture and the development of rural life : overview 2004/2005. - Tallinn, 2005, lk. 34-41. Teravilja, teraviljasaadusi ja muid toiduaineid töötlev tööstus annab väärtuseliselt ligikaudu 18% Eesti toiduainetööstuse kogutoodangust. Diagrammid. Tabel

  6. Operation of the TSTA (Tritium Systems Test Assembly) with 100 gram tritium

    International Nuclear Information System (INIS)

    Sherman, R.H.; Bartlit, J.R.

    1988-01-01

    In March of 1988 full operation of the 4-column isotope separation system (ISS) was realized in runs that approximated the design load of tritium. Previous operations had been fraught with operating difficulties principally due to external systems. This report will examine the recent highly successful 6-day period of operation. During this time the system was cooled from room temperature, loaded with hydrogen isotopes including 109 grams of tritium, integrated with the transfer pumping, impurity injection, and impurity removal systems, as well as the remote computer control system. At the end of the operation 12 grams of tritium having a measured purity of 99.987% (remainder deuterium) were offloaded from the system. Observed profiles in the columns in general agree with computer models. A Height Equivalent to a Theoretical Plate (HETP) of 5.0 cm is confirmed. 3 refs., 5 figs

  7. NATO "röövib" Eestilt kogu jõueliidi / Tuuli Koch

    Index Scriptorium Estoniae

    Koch, Tuuli

    2008-01-01

    Bukarestis toimuvatel NATO tippkohtumisega seotud üritustel esindavad Eestit president Toomas Hendrik Ilves, peaminister Andrus Ansip, välisminister Urmas Paet, kaitseminister Jaak Aaviksoo ja kaitseväe juhataja kindralmajor Ants Laaneots. Poliitikute päevakavast. President T. H. Ilves esineb NATO temaatikaga tegelevate noorteorganisatsioonide esindajate konverentsil ning mõttekoja German Marshall Fund korraldataval konverentsil "The Bucharest Conference". Vabariigi President töövisiidil Bukarestis 1.-3.04.2008

  8. Synthesis and physicochemical study of complexes of metals of subgroup VIB with amino alcohols

    Energy Technology Data Exchange (ETDEWEB)

    Spitsyn, V.I.; Mozgin, S.V.; Subbotina, N.A.; Felin, M.G.

    1982-04-01

    New mixed-ligand complexes of chromium(III) with glycine and mono- and diethanolamines and a number of new complexes of molybdenum(VI) and of tungsten(VI) with ethanolamines and aminopropanols have been obtained; the physicochemical investigation of the complexes obtained by various methods has been made. A structure has been proposed for the coordination sphere of the complexes isolated and the dependence of the composition of the products formed on the nature of the central atom and on the properties of the ligands used have been explained.

  9. Töö röövib lastelt vanemad / Marion Pajumets

    Index Scriptorium Estoniae

    Pajumets, Marion

    2012-01-01

    Triin Roosalu Tallinna Ülikoolis kaitstud doktoriväitekirjast "Taking care of children and work in Estonian society : running out of post-socialist time?", mis käsitleb Eesti töö ja pereelu ühitamise mudelit

  10. Gaas arvudes ja protsentides

    Index Scriptorium Estoniae

    2007-01-01

    Diagrammid: Primaarenergia tarbimise struktuur Eestis; Maagaasi tarbimine Eestis 1996-2006; Maagaasi tarbimine kliendigruppide lõikes 2004-2006; Vedelgaasi tarbimine Eestis 1996-2006; Vedelgaasi tarbimise struktuur 2004-2006; Primaarenergia tarbimine 2005 regiooniti; Primaarenergia tarbimine maailmas 1980-2005; Maagaasi tõendatud varud maailmas 2005 aasta lõpuks; Maagaasi varude jaotumine regiooniti aastatel 85, 95 ja 2005; Maagaasi tootmine ja tarbimine regiooniti; Maagaasi varude suhe tootmismahtudesse; Maagaasi tootmine ja tarbimine riigiti 2005; Vedelgaasi nõudlus ja tootmine regiooniti. Kaardid. Graafikud

  11. Gaas arvudes ja protsentides = Gas in figures and percentages

    Index Scriptorium Estoniae

    2006-01-01

    Diagrammid: Primaarenergia tarbimise struktuur Eestis; Maagaasi tarbimine Eestis 1995-2005; Maagaasi tarbimine kliendigruppide lõikes 2003-2005; Vedelgaasi tarbimine Eestis 1995-2005; Vedelgaasi tarbimise struktuur 2003-2005; Primaarenergia tarbimine 2004 regiooniti; Maagaasi tõendatud varud maailmas 2004 aasta lõpuks; Maagaasi varude jaotumine regiooniti aastatel 84, 94, 04; Maagaasi varude suhe tootmismahtudesse (2004); Maagaasi tootmine riigiti (2004); Maagaasi tarbimine riigiti (2004). Kaardid. Graafikud

  12. Gaas arvudes ja protsentides (Eestis ja maailmas)

    Index Scriptorium Estoniae

    2005-01-01

    Diagrammid: Primaarenergia tarbimise struktuur Eestis; Maagaasi tarbimine Eestis; Maagaasi tarbimine kliendigruppide lõikes 2002-2004; Vedelgaasi tarbimine Eestis; Vedelgaasi tarbimise struktuur Eestis 2003-2004; Maailma primaarenergia tarbimise struktuur 2002; Välisõhku eralduvate saasteainete kogused erinevate kütuseliikide põletamisel. Kaardid: Euroopa maagaasi ülekandetorustikud; Maagaas Eestis

  13. Gas in figures and percentages (in Estonia and in the world)

    Index Scriptorium Estoniae

    2005-01-01

    Diagrammid: Primaarenergia tarbimise struktuur Eestis; Maagaasi tarbimine Eestis; Maagaasi tarbimine kliendigruppide lõikes 2002-2004; Vedelgaasi tarbimine Eestis; Vedelgaasi tarbimise struktuur Eestis 2003-2004; Maailma primaarenergia tarbimise struktuur 2002; Välisõhku eralduvate saasteainete kogused erinevate kütuseliikide põletamisel. Kaardid: Euroopa maagaasi ülekandetorustikud; Maagaas Eestis

  14. Operating experience and procedures at the tritium systems test assembly

    International Nuclear Information System (INIS)

    Carlson, R.V.; Binning, K.E.; Cole, S.P.; Jenkins, E.M.; Wilhelm, R.C.; Cole, S.P.

    1988-01-01

    Operating procedures are important for the safe and efficient operation of the Tritium Systems Test Assembly (TSTA). TSTA has been operating for four years with tritium in a safe and efficient manner. The inventory of tritium in the process loop is 100 grams and several milestone runs have been completed. This paper describes the methods used to operate TSTA. 3 refs., 1 fig

  15. Vedelgaasi kasutamine Eestis 2005. aastal / Sandor Tabo

    Index Scriptorium Estoniae

    Tabo, Sandor

    2006-01-01

    2005. a. kasvas Eestis vedelgaasi tarbimine võrreldes 2004. aastaga 11%. Diagramm: Vedelgaasi tarbimine Eestis 2005. a. tonnides. Graafik: Vedelgaasi propaan maailmaturu hind USD/tonn. Tabel Eesti vedelgaasiäriühingute terminalide võimsuse ja müügiviiside kohta

  16. Data base for failure/maintenance at the Tritium Systems Test Assembly

    International Nuclear Information System (INIS)

    Gruetzmacher, K.M.; Wilhelm, R.C.

    1986-01-01

    A data collection system for obtaining availability/reliability data on fusion technology has been installed at the Tritium Systems Test Assembly (TSTA) of Los Alamos National Laboratory. The system is fashioned after the Centralized Reliability Data Organization developed at Oak Ridge National Laboratory. The data collection system is currently being used at TSTA and is working well. The amount of data that has been collected at TSTA to date is not sufficient to indicate meaningful trends in availability analysis

  17. Kättemaksu tund läheneb - hangunud verele ülesklopsitud röövriik hävib! : vastupanuliikumise salatrükikoda "Punker Tiiu" Kambja vallas 1947.-1948. aastal / Tiit Noormets

    Index Scriptorium Estoniae

    Noormets, Tiit, 1959-

    2006-01-01

    Põrandaaluse salatrükikoja أPunker Tiiuؤ (1947-1948) tegevusest, lendlehtede levitamisest Tartumaal. Dokument: "Väljavõte ENSV RJM Tartu linna osakonna 2-N jaoskonna tööaruandest 1949. a. septembrikuu kohta"

  18. Comments on "Drill-string horizontal dynamics with uncertainty on the frictional force" by T.G. Ritto, M.R. Escalante, Rubens Sampaio, M.B. Rosales [J. Sound Vib. 332 (2013) 145-153

    Science.gov (United States)

    Li, Zifeng

    2016-12-01

    This paper analyzes the mechanical and mathematical models in "Ritto et al. (2013) [1]". The results are that: (1) the mechanical model is obviously incorrect; (2) the mathematical model is not complete; (3) the differential equation is obviously incorrect; (4) the finite element equation is obviously not discretized from the corresponding mathematical model above, and is obviously incorrect. A mathematical model of dynamics should include the differential equations, the boundary conditions and the initial conditions.

  19. Nord Stream tuleb Venemaa gaasihiiule raskel ajal / Jaanus Piirsalu ; kommenteerinud Mihhail Kortšemkin

    Index Scriptorium Estoniae

    Piirsalu, Jaanus, 1973-

    2010-01-01

    Gazpromi tähtsus "energeetikarelvana" on hakanud kahanema - Euroopas on gaasi tarbimine vähenenud, mitmed gaasitootjad pakuvad Euroopale Vene gaasiga hinna poolest edukalt konkureerivat vedelgaasi, USA-s toodetakse üha enam kildagaasi

  20. Abuses of sugar market in Latvia, Estonia under spotlight

    Index Scriptorium Estoniae

    2004-01-01

    Läti konkurentsiamet sulges hindade mõjutamise tõttu riigi suuruselt teise suhkruvabriku. Eestit trahvitakse suhkru varumise eest enne Euroopa Liitu astumist. Leedus on aga suhkru tarbimine langenud

  1. Political liberalization / Olga Pavuk, Hannes Tamme, Zidrunas Damauskas

    Index Scriptorium Estoniae

    Pavuk, Olga

    2001-01-01

    Ilmunud ka: Baltiiskii Kurss, nr. 19, 2001, lk. 20-23. Kütuseturu hetkeseisust Balti riikides. Diagrammid: maagaasi tarbimine Baltimaades 1997-2000; Energiatarbimine Eestis kütuseliikide kaupa 1995. ning prognoosid 2005. ja 2010. aastaks

  2. Briti õlu kui majandusharu / Arne Kaldes

    Index Scriptorium Estoniae

    Kaldes, Arne

    2000-01-01

    Suurbritannia jaoks on õlu oluline ekspordiartikkel. Tabelid: õlletoodang Euroopa Liidus 1998.a., Suurbritannia õlleeksport 1998.a., õlle tarbimine Euroopas 1999.a., Euroopa Liidu suurimad õlleeksportöörid

  3. Strong demand despite increased excise duty / Ella Karapetyan

    Index Scriptorium Estoniae

    Karapetyan, Ella

    2010-01-01

    Ettevõtte Liviko juht Janek Kalvi räägib alkohoolsete jookide turust Eestis, ettevõtte tegevusest ja investeeringutest. Kuigi Eestis tõusis alkohoolsete jookide aktsiis, ei ole tarbimine vähenenud

  4. Gaas arvudes ja protsentides (Eestis ja maailmas) = Gas in figures and percentages (in Estonia and in the world)

    Index Scriptorium Estoniae

    2004-01-01

    Primaarenergia tarbimise struktuur Eestis, maailmas; maa- ja vedelgaasi tarbimine ning struktuur Eestis; välisõhku eralduvate saasteainete kogused erinevate kütuseliikide põletamisel. Diagrammid. Kaart: Maagaas Eestis.

  5. Gaas arvudes ja protsentides (Eestis ja maailmas) = Gas in figures and percentages (in Estonia and in the world)

    Index Scriptorium Estoniae

    2003-01-01

    Primaarenergia tarbimise struktuur Eestis, maailmas; maa-, vedelgaasi tarbimine ja struktuur Eestis, maailmas; välisõhku eralduvate saasteainete kogused erinevate kütuseliikide põletamisel. Diagrammid. Kaart: Maagaas Eestis

  6. Subsystem cost data for the tritium systems test assembly

    International Nuclear Information System (INIS)

    Bartlit, J.R.; Anderson, J.L.; Rexroth, V.G.

    1983-01-01

    Details of subsystem costs are among the questions most frequently asked about the $14.4 million Tritium Systems Test Assembly (TSTA) at Los Alamos National Laboratory. This paper presents a breakdown of cost components for each of the 20 major subsystems of TSTA. Also included are details to aid in adjusting the costs to other years, contracting conditions, or system sizes

  7. Subsystem cost data for the tritium systems test assembly

    Energy Technology Data Exchange (ETDEWEB)

    Bartlit, J.R.; Anderson, J.L.; Rexroth, V.G.

    1983-01-01

    Details of subsystem costs are among the questions most frequently asked about the $14.4 million Tritium Systems Test Assembly (TSTA) at Los Alamos National Laboratory. This paper presents a breakdown of cost components for each of the 20 major subsystems of TSTA. Also included are details to aid in adjusting the costs to other years, contracting conditions, or system sizes.

  8. Tritium Systems Test Assembly: design for major device fabrication review

    International Nuclear Information System (INIS)

    Anderson, J.L.; Sherman, R.H.

    1977-06-01

    This document has been prepared for the Major Device Fabrication Review for the Tritium Systems Test Assembly (TSTA). The TSTA is dedicated to the development, demonstration, and interfacing of technologies related to the deuterium-tritium fuel cycle for fusion reactor systems. The principal objectives for TSTA are: (a) demonstrate the fuel cycle for fusion reactor systems; (b) develop test and qualify equipment for tritium service in the fusion program; (c) develop and test environmental and personnel protective systems; (d) evaluate long-term reliability of components; (e) demonstrate long-term safe handling of tritium with no major releases or incidents; and (f) investigate and evaluate the response of the fuel cycle and environmental packages to normal, off-normal, and emergency situations. This document presents the current status of a conceptual design and cost estimate for TSTA. The total cost to design, construct, and operate TSTA through FY-1981 is estimated to be approximately $12.2 M

  9. Tritium handling safety and operating experience at the Tritium Systems Test Assembly

    Energy Technology Data Exchange (ETDEWEB)

    Carlson, R.V.

    1989-01-01

    The Tritium Systems Test Assembly (TSTA) at Los Alamos National Laboratory is a facility designed to develop and demonstrate, in full scale, technologies necessary for safe and efficient operation of tokamak fusion reactors. TSTA currently consists of systems for pumping DT gas mixtures; for removing impurities; for separating the isotopes of hydrogen; for storage of hydrogen isotopes; for gas analysis; and for assuring safety by the necessary control, monitoring, and detritiation of effluent gaseous streams. TSTA also has several small scale experiments to develop and test new equipment and processes necessary for fusion reactors. Tritium was introduced into TSTA in June 1984. Current inventory is approximately 100 grams. Approximately 10{sup 9} Curies of tritium have been processed in closed loop operation at TSTA. Total tritium releases from the facility stack have been less than 75 Curies. Total operating personnel exposures are less than 500 person-mrem. Exposures to the general public from TSTA tritium releases are extremely small (less than 10{sup {minus}2} mrem). Total tritium buried as waste is less than 36,000 Curies. In this paper, data on component reliability, failure types and rates, and waste quantities are presented. Operational experience under normal, abnormal, and emergency conditions is presented. The DOE requirements for the operation of a tritium facility like TSTA include personnel training, emergency preparedness, radiation protection, safety analysis, and preoperational appraisals. 4 refs., 3 figs., 3 tabs.

  10. Tritium systems test assembly quality assurance program

    International Nuclear Information System (INIS)

    Kerstiens, F.L.; Wilhelm, R.C.

    1986-07-01

    A quality assurance program should establish the planned and systematic actions necessary to provide adequate confidence that fusion facilities and their subsystems will perform satisfactorily in service. The Tritium Systems Test Assembly (TSTA) Quality Assurance Program has been designed to assure that the designs, tests, data, and interpretive reports developed at TSTA are valid, accurate, and consistent with formally specified procedures and reviews. The quality consideration in all TSTA activities is directed toward the early detection of quality problems, coupled with timely and positive disposition and corrective action

  11. Improved production of cytotoxic thailanstatins A and D through metabolic engineering of Burkholderia thailandensis MSMB43 and pilot scale fermentation

    Directory of Open Access Journals (Sweden)

    Xiangyang Liu

    2016-03-01

    Full Text Available Thailanstatin A (TST-A is a potent antiproliferative natural product discovered by our group from Burkholderia thailandensis MSMB43 through a genome-guided approach. The limited supply of TST-A, due to its low titer in bacterial fermentation, modest stability and very low recovery rate during purification, has hindered the investigations of TST-A as an anticancer drug candidate. Here we report the significant yield improvement of TST-A and its direct precursor, thailanstatin D (TST-D, through metabolic engineering of the thailanstatin biosynthetic pathway in MSMB43. Deletion of tstP, which encodes a dioxygenase involved in converting TST-A to downstream products including FR901464 (FR, resulted in 58% increase of the TST-A titer to 144.7 ± 2.3 mg/L and 132% increase of the TST-D titer to 14.6 ± 0.5 mg/L in the fermentation broth, respectively. Deletion of tstR, which encodes a cytochrome P450 involved in converting TST-D to TST-A, resulted in more than 7-fold increase of the TST-D titer to 53.2 ± 12.1 mg/L in the fermentation broth. An execution of 90 L pilot-scale fed-batch fermentation of the tstP deletion mutant in a 120-L fermentor led to the preparation of 714 mg of TST-A with greater than 98.5% purity. The half-life of TST-D in a phosphate buffer was found to be at least 202 h, significantly longer than that of TST-A or FR, suggesting superior stability. However, the IC50 values of TST-D against representative human cancer cell lines were determined to be greater than those of TST-A, indicating weaker antiproliferative activity. This work enabled us to prepare sufficient quantities of TST-A and TST-D for our ongoing translational research.

  12. Role of vibrationally excited HBr in a HBr/He inductively coupled plasma used for etching of silicon

    Science.gov (United States)

    Tinck, Stefan; Bogaerts, Annemie

    2016-06-01

    In this work, the role of vibrationally excited HBr (HBr(vib)) is computationally investigated for a HBr/He inductively coupled plasma applied for Si etching. It is found that at least 50% of all dissociations of HBr occur through HBr(vib). This additional dissociation pathway through HBr(vib) makes the plasma significantly more atomic. It also results in a slightly higher electron temperature (i.e. about 0.2 eV higher compared to simulation results where HBr(vib) is not included), as well as a higher gas temperature (i.e. about 50 K higher than without including HBr(vib)), due to the enhanced Franck-Condon heating through HBr(vib) dissociation, at the conditions investigated. Most importantly, the calculated etch rate with HBr(vib) included in the model is a factor 3 higher than in the case without HBr(vib), due to the higher fluxes of etching species (i.e. H and Br), while the chemical composition of the wafer surface shows no significant difference. Our calculations clearly show the importance of including HBr(vib) for accurate modeling of HBr-containing plasmas.

  13. Põllumajandussaaduste eksport ja import Eestis 1995. aastal / Ene Maadvere

    Index Scriptorium Estoniae

    Maadvere, Ene, 1948-

    1996-01-01

    Tabelid: Kaupade eksport ja import Eestis; Põhiliste kaubagruppide osatähtsuse muutumine toidukaupade ekspordis; Hinnad; Mõnede toidukaupade eksport 1995.a. võrreldes 1994.a.; Imporditud toidukaupade struktuur võrreldes 1995.a.; Nisuhind Chicago börsil. Diagrammid: Liha-piima tootmine, tarbimine, eksport ja tonnides; Põllumajandussaaduste eksport 1995.a. riikide lõikes

  14. Euroopa muretseb narkomaania pärast Eestis / Alain Wallon ; interv. Andri Maimets

    Index Scriptorium Estoniae

    Wallon, Alain

    2004-01-01

    Euroopa Narkoseire Keskuse hinnangul peab Eesti riik võitluses uimastitega rohkem tähelepanu pöörama venekeelsele kogukonnale. Euroopa Liidu uimastiseire aruandega kutsutakse liikmesriike üles tegelema aktiivselt narkopoliitikaga ja aitama väiksemaid riike. Kaart: Kanepi tarbimine Euroopas. Vt. samas Andri Maimets. Euroopa noored kanepi küüsis

  15. Gazprom teeb reformi: Ukrainal on aeg gaasipliidid nurka visata / Heiki Suurkask

    Index Scriptorium Estoniae

    Suurkask, Heiki, 1972-

    2009-01-01

    Autor leiab, et Ukraina pole 2006. a. kriisist midagi õppinud, maagaasi tarbimine on veelgi suurenenud. Gaasihinna tõusu korral hakatakse Ukrainas ilmselt üha enam loobuma gaasipliitidest ja -boileritest ning niimoodi kaotaks Gazprom ühe oma suurema turu. Gazprom üritab kõrgemat gaasihinda saavutada ka SRÜ maades. Diagrammid

  16. Changes in foodstuffs consumption in Estonia and other candidate countries of the EU / Tõnu Akkel

    Index Scriptorium Estoniae

    Akkel, Tõnu, 1936-

    2003-01-01

    Muutused toiduainete tarbimises Eestis ja teistes Euroopa Liidu kandidaatmaades. 90-ndate lõpul toimunud poliitilised ja majanduslikud muutused Ida-Euroopa riikides mõjusid ka toiduainete tarbimisele, eeskätt vähenesid kallimate toiduainete, sh liha- ja piimasaaduste tarbimine. Tabelid. Diagrammid

  17. Tere tulemast, Suncor?! / Erik Puura

    Index Scriptorium Estoniae

    Puura, Erik, 1964-

    2000-01-01

    Eesti Põlevkivisse investeerida sooviva Kanada tööstusgigandi Suncor Energy vastu protesteerib maailma juhtiv keskkonnakaitseorganisatsioon Greenpeace. Suncor Energy põlevkivi töötlemise projekt Austraalias. Tabel: Põlevkivi tarbimine, õlisaak ja CO₂ lisakogus Austraalias ning Eestis. 2007. ja 2010.a.

  18. Eesti ajab autotranspordis konservatiivset kütusepoliitikat / Imbi Ernits-Kaljuste

    Index Scriptorium Estoniae

    Ernits-Kaljuste, Imbi, 1963-

    2008-01-01

    2007. aastal oli bensiini ja diislikütuse kogutarbimine Eestis 1,1 mld liitrit, millest biokütus moodustas 0,06%. Prognoosi kohaselt võiks kütuse tarbimine 2010. aastal ulatuda Eestis 943 000 tonnini, millest 100%-line biodiislikütus moodustaks 9,45 ja 95%-line bioetanool 7,13%

  19. Alkoholi tootmine ja turg : [2002-2004] / Katrin Karolin

    Index Scriptorium Estoniae

    Karolin, Katrin

    2005-01-01

    Ilmunud ka: Agriculture and the development of rural life : overview 2004/2005. - Tallinn, 2005, lk. 45-47. 2004. a. 9 kuu alkoholi jaekäive ulatus 2,2 mld kroonini, mis on 13% suurem kui eelmise aasta samal perioodil. Tabelid: Alkohoolsete jookide tootmine Eestis (9 kuud 2002-2004); Alkoholi tarbimine elanike hinnangute alusel

  20. In vino veritas /cОльга Павук, Вакарис Декснис, Александр Вене

    Index Scriptorium Estoniae

    Павук, Ольга

    2001-01-01

    Alkoholi tootmisest, tarbimisest, ekspordist-impordist ja salakaubandusest Baltimaades. Tabelid ja diagrammid: kohalike alkoholitoojate osakaal Läti turul 2000; alkoholi tarbimine Lätis 2000 ja 2001 I kvartalis; alkoholi tootmine Leedus 1990-2001; kohalike suuremate viinatootjate turuosa Eestis 1998-2001 (9 kuud). Ilmunud ka: Baltiiskii kurss, nr. 19, 2001, lk. 34-37

  1. Bioenergia kasutuselevõtt tuleneb elust endast / Andres Oopkaup

    Index Scriptorium Estoniae

    Oopkaup, Andres, 1966-

    2006-01-01

    Ilmunud ka: Molodjozh Estonii : Selskii Vestnik 16. dets. lk. 2. Taastuvate energiaressursside kasutuselevõtu olulisus; Eesti biomassi ja bioenergia kasutamise edendamise arengukava aastateks 2007-2013. Tabel: Puit- ja turbakütuste tootmine. Lisa: Biomassi kasutuselevõtt energia ja materjalide tootmises. Diagrammid: Kütuse primaarenergiaga varustatus, 2005; Kütuse tarbimine elektri tootmiseks, 2005

  2. Alcohol producers battle illegal market and shadow economy / Alina Lisina

    Index Scriptorium Estoniae

    Lisina, Alina

    2010-01-01

    Läti alkoholimüük on vähenenud ja selle põhjuseks võib olla salaalkoholi tarbimine. Läti valitsus alandab aktisiimaksu, et vähendada salaalkoholi tarbimist ja saada riigieelarvesse lisaraha. Alkoholitootja Latvijas Balzams majandustulemustest

  3. Vedelgaasi kasutamine Eestis 2006. aastal / Sandor Tabo

    Index Scriptorium Estoniae

    Tabo, Sandor

    2007-01-01

    Eesti vedelgaasiturg, müügikasv vedelgaasi kasutusviisi järgi. Diagramm: Vedelgaasi tarbimine Eestis 2001-2006. a. Tabel: Eesti vedelgaasiäriühingute peamised näitajad 2005-2006. a. Graafik: Vedelgaasi propaan hind maailmaturul 2002-2006. a.

  4. Rebimine leivatööstuses / Ede Schank

    Index Scriptorium Estoniae

    Schank, Ede

    2004-01-01

    Eestis on oluliselt suurenenud pagaritööstuste arv ja leivatoodete valik, kuid tarbimine on samal ajal vähenenud. Ettevõtete tegevust ja eestlaste tarbimiseelistusi tutvustavad Lauri Liipa Fazer Eestist ja Marika Tali Hallikust. Diagramm: Pagaritööstuste turujaotus (2002)

  5. Experimental Tritium Cleanup System availability analysis from 1984 to 1992

    International Nuclear Information System (INIS)

    Cadwallader, L.C.; Taylor, G.L.

    1993-05-01

    This report gives the availability percentage of the Experimental Tritium Cleanup System (ETC) at the Tritium Systems Test Assembly (TSTA), which is a fusion research and technology facility at the Los Alamos National Laboratory. The component failure reports, the numbers of components, and operating times or demands are all given in this report. Sample calculations of the failure rates obtained from these data are given in the appendices. While future fusion experiments might use different or more advanced means to detritiate room air, the analysis of this system gives a data point for an actual detritiation system. Such a data point can be extrapolated for comparison with fault tree results on system designs, or can be used in a Bayesian failure rate analysis for estimating reliability of a new type of system. The nine years of testing operations on TSTA's ETC result in a reasonable average availability value of 92% for the maximal tritium release event. The failure rates for new systems are expected to be lower than for the TSTA ETC, since improvements will be made in the design of the room air detritiation system based on the TSTA system experiences. Nonetheless, these TSTA data should be useful for future fusion reactor design work and safety assessment tasks

  6. Untitled

    Indian Academy of Sciences (India)

    Munjal M L, Shirahatti US 1987 Analysis of lined ducts with mean flow, with application to dissipative mufflers. Trans. ASME (J. Vib, Acoust. Stress Reliability) tú9:366-371. Munjal M L, Sreenath AV, Narasimhan M V 1973b Velocity ratio in analysis of linear dynamical systems. J. Sound Vib, 26. #73–191. Munjal M L Sreenath ...

  7. Untitled

    Indian Academy of Sciences (India)

    (New York: Manchester Univ. Press Barnes and Noble Inc.) Ch. 1. Bechert D and Pfizenmaier E 1975 J. Sound Vib. 43 581. Billingsley J and Kinns R 1976.J. Sound Vib. 484. Candel S M 1972 Ph.D. Thesis Cal. Inst. of Tech. Crighton D G and Leppington F G 1971 J. Fluid Mech. 46577. Crighton D G 1972. J. Fluid Mech.

  8. The Shock and Vibration Digest. Volume 16, Number 12

    Science.gov (United States)

    1984-12-01

    constructed Vib. Bull., No. 54, Pt. 1, pp 23-41 (June 1984) 25 and applied to the experiments of Hirano and Murakami who figs (Proc. Shock Vib. Symp., Oct...1093 Bezler, P ........ 345, 678, 1152 Borg , S.F ................... 922 Baxter, S.M ................ 2749 Bhat, R.A .................. 1142 Bort

  9. Improving Legacy Aircraft Systems Through Condition-Based Maintenance: An H-60 Case Study

    Science.gov (United States)

    2014-09-01

    Multifunction Display MMP Monthly Maintenance Plan MOP measure of performance MRC Maintenance Requirement Card MTBM Mean Time Between Maintenance NAE ...Model/Series TD technical directive TM Type Maintenance Code VGA Value Gap Analysis VIB-100 Vibration Analysis Manual (ATABS) xv VIB-200...preventive maintenance. (This includes on-equipment repair, removal, and replacement of defective components.) e. Incorporation of TDs , less SE

  10. Atrophy/hypertrophy cell signaling in muscles of young athletes trained with vibrational-proprioceptive stimulation.

    Science.gov (United States)

    Kern, Helmut; Pelosi, Laura; Coletto, Luisa; Musarò, Antonio; Sandri, Marco; Vogelauer, Michael; Trimmel, Lukas; Cvecka, Jan; Hamar, Dusan; Kovarik, Josef; Löfler, Stefan; Sarabon, Nejc; Protasi, Feliciano; Adami, Nicoletta; Biral, Donatella; Zampieri, Sandra; Carraro, Ugo

    2011-12-01

    To compare the effects of isokinetic (ISO-K) and vibrational-proprioceptive (VIB) trainings on muscle mass and strength. In 29 ISO-K- or VIB-trained young athletes we evaluated: force, muscle fiber morphometry, and gene expression of muscle atrophy/hypertrophy cell signaling. VIB training increased the maximal isometric unilateral leg extension force by 48·1%. ISO-K training improved the force by 24·8%. Both improvements were statistically significant (P⩿0·01). The more functional effectiveness of the VIB training in comparison with the ISO-K training was shown by the statistical significance changes only in VIB group in: rate of force development in time segment 0-50 ms (Pmuscle fibers (-3%, not significant). No neural cell adhesion molecule-positive (N-CAM(+)) and embryonic myosin heavy chain-positive (MHC-emb(+)) myofibers were detected. VIB induced a significant twofold increase (Pmuscle isoform insulin-like growth factor-1 (IGF-1) Ec mRNA. Atrogin-1 and muscle ring finger-1 (MuRF-1) did not change, but myostatin was strongly downregulated after VIB training (Pmuscle damage. Only VIB-trained group showed statistical significance increase of hypertrophy cell signaling pathways (IGF-1Ec and PGC-1α upregulation, and myostatin downregulation) leading to hypertrophy of fast twitch muscle fibers.

  11. Designing a Virtual Item Bank Based on the Techniques of Image Processing

    Science.gov (United States)

    Liao, Wen-Wei; Ho, Rong-Guey

    2011-01-01

    One of the major weaknesses of the item exposure rates of figural items in Intelligence Quotient (IQ) tests lies in its inaccuracies. In this study, a new approach is proposed and a useful test tool known as the Virtual Item Bank (VIB) is introduced. The VIB combine Automatic Item Generation theory and image processing theory with the concepts of…

  12. Advances in nonlinear vibration analysis of structures. Part-I. Beams

    Indian Academy of Sciences (India)

    Unknown

    J. Sound Vib. 123: 517–527. Evensen D A 1968 Nonlinear vibrations of beams with various boundary conditions. AIAA J. 6: 370–372. Heyliger P R, Reddy J N 1988 A higher order beam finite element for bending and vibration problems. J. Sound Vib. 126: 309–326. Kapania R K, Raciti S 1989a Recent advances in analysis ...

  13. Tritium contaminated waste management at the tritium systems test assembly

    International Nuclear Information System (INIS)

    Jalbert, R.A.; Carlson, R.V.

    1987-01-01

    The Tritium Systems Test Assembly (TSTA) at Los Alamos continues to move toward full operation of an integrated, full-sized, computer-controlled fusion fuel processing loop. Concurrent nonloop experiments further the development of advanced tritium technologies and handling methods. Since tritium operations began in June 1984, tritium contaminated wastes have been produced at TSTA that are roughly typical in kind and amount of those to be produced by tritium fueling operations at fusion reactors. Methods of managing these wastes are described, including information on some methods of decontamination so that equipment can be reused. Data are given on the kinds and amounts of wastes and the general level of contamination. Also included are data on environmental emissions and doses to personnel that have resulted from TSTA operations. Particular problems in waste managements are discussed

  14. Reactive codoping of GaAlInP compound semiconductors

    Science.gov (United States)

    Hanna, Mark Cooper [Boulder, CO; Reedy, Robert [Golden, CO

    2008-02-12

    A GaAlInP compound semiconductor and a method of producing a GaAlInP compound semiconductor are provided. The apparatus and method comprises a GaAs crystal substrate in a metal organic vapor deposition reactor. Al, Ga, In vapors are prepared by thermally decomposing organometallic compounds. P vapors are prepared by thermally decomposing phospine gas, group II vapors are prepared by thermally decomposing an organometallic group IIA or IIB compound. Group VIB vapors are prepared by thermally decomposing a gaseous compound of group VIB. The Al, Ga, In, P, group II, and group VIB vapors grow a GaAlInP crystal doped with group IIA or IIB and group VIB elements on the substrate wherein the group IIA or IIB and a group VIB vapors produced a codoped GaAlInP compound semiconductor with a group IIA or IIB element serving as a p-type dopant having low group II atomic diffusion.

  15. Noninvasive in vivo monitoring of neuronal differentiation using reporter driven by a neuronal promoter

    International Nuclear Information System (INIS)

    Hwang, Do Won; Kang, Joo Hyun; Lee, Myung Chul; Jeong, Jae Min; Chung, June-Key; Kim, Soonhag; Lee, Dong Soo

    2008-01-01

    We imaged neuronal differentiation in vivo using dual reporters (sodium iodide symporter [NIS] and luciferase) coupled to a neuron-specific enolase (NSE) promoter. PC12 (NSE positive) and F11 cells were transfected with a bicistronic (NIS and luciferase; pNSE-NF) or a luciferase (pNSE-Fluc) reporter coupled to the NSE promoter. Weak NSE promoter activity was overcome by a two-step transcriptional amplification (TSTA) system (pNSE-TSTA-Fluc). In vivo, NIS and luciferase expression were examined using a 99m Tc-pertechnetate gamma camera and bioluminescence imaging, respectively. pNSE-NF-transfected PC12 cells showed 3-fold higher radioiodine uptakes and >100-fold higher luciferase activity than parental cells. NIS or luciferase activity was not detected in pNSE-NF-transfected HeLa cells. When F11 cells were differentiated into neurons by db-cAMP, NIS and luciferase activities increased 4-fold compared to those without treatment, which was confirmed by Western blot and RT-PCR of NSE. In vivo in pNSE-NF-transfected F11 cells, db-cAMP treatment increased the luciferase activity but not the scintigraphic activity. In vitro, pNSE-TSTA-Fluc produced 130-fold higher luciferase activity than pNSE-Fluc and neuronal differentiation showed 4-fold higher activity from both pNSE-TSTA-Fluc and pNSE-Fluc than before differentiation. In vivo, in pNSE-TSTA-Fluc-transfected F11 cells, luciferase activity increased after neuronal differentiation. In vivo luciferase activity persisted up to 2 days after db-cAMP-induced neuronal differentiation. NSE promoter-driven dual reporter transgenes revealed the possibility of in vivo imaging of neuronal differentiation, which was further enabled by high amplification using a TSTA system. We propose that this strategy be used to follow the transplanted stem cells during differentiation in live animals. (orig.)

  16. Noninvasive in vivo monitoring of neuronal differentiation using reporter driven by a neuronal promoter

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Do Won [Seoul National University, Programs in Neuroscience, Seoul (Korea); Seoul National University College of Medicine, Department of Nuclear Medicine, Seoul (Korea); Seoul National University College of Medicine, Laboratory of Molecular Imaging and Therapy of Cancer Research Institute, Seoul (Korea); Kang, Joo Hyun; Lee, Myung Chul [Seoul National University College of Medicine, Department of Nuclear Medicine, Seoul (Korea); Jeong, Jae Min; Chung, June-Key [Seoul National University College of Medicine, Department of Nuclear Medicine, Seoul (Korea); Seoul National University College of Medicine, Laboratory of Molecular Imaging and Therapy of Cancer Research Institute, Seoul (Korea); Kim, Soonhag [Seoul National University College of Medicine, Department of Nuclear Medicine, Seoul (Korea); Seoul National University College of Medicine, Medical Research Center, Seoul (Korea); Lee, Dong Soo [Seoul National University, Programs in Neuroscience, Seoul (Korea); Seoul National University College of Medicine, Department of Nuclear Medicine, Seoul (Korea); Seoul National University Hospital, Department of Nuclear Medicine, Seoul (Korea)

    2008-01-15

    We imaged neuronal differentiation in vivo using dual reporters (sodium iodide symporter [NIS] and luciferase) coupled to a neuron-specific enolase (NSE) promoter. PC12 (NSE positive) and F11 cells were transfected with a bicistronic (NIS and luciferase; pNSE-NF) or a luciferase (pNSE-Fluc) reporter coupled to the NSE promoter. Weak NSE promoter activity was overcome by a two-step transcriptional amplification (TSTA) system (pNSE-TSTA-Fluc). In vivo, NIS and luciferase expression were examined using a {sup 99m}Tc-pertechnetate gamma camera and bioluminescence imaging, respectively. pNSE-NF-transfected PC12 cells showed 3-fold higher radioiodine uptakes and >100-fold higher luciferase activity than parental cells. NIS or luciferase activity was not detected in pNSE-NF-transfected HeLa cells. When F11 cells were differentiated into neurons by db-cAMP, NIS and luciferase activities increased 4-fold compared to those without treatment, which was confirmed by Western blot and RT-PCR of NSE. In vivo in pNSE-NF-transfected F11 cells, db-cAMP treatment increased the luciferase activity but not the scintigraphic activity. In vitro, pNSE-TSTA-Fluc produced 130-fold higher luciferase activity than pNSE-Fluc and neuronal differentiation showed 4-fold higher activity from both pNSE-TSTA-Fluc and pNSE-Fluc than before differentiation. In vivo, in pNSE-TSTA-Fluc-transfected F11 cells, luciferase activity increased after neuronal differentiation. In vivo luciferase activity persisted up to 2 days after db-cAMP-induced neuronal differentiation. NSE promoter-driven dual reporter transgenes revealed the possibility of in vivo imaging of neuronal differentiation, which was further enabled by high amplification using a TSTA system. We propose that this strategy be used to follow the transplanted stem cells during differentiation in live animals. (orig.)

  17. Development of tritium technology at the Tritium Systems Test Assembly

    International Nuclear Information System (INIS)

    Anderson, J.L.; Bartlit, J.R.

    1982-01-01

    The Tritium Systems Test Assembly (TSTA) at the Los Alamos National Laboratory is dedicated to the development, demonstration, and interfacing of technologies related to the deuterium-tritium fuel cycle for large scale fusion reactor systems starting with the Fusion Engineering Device (FED) or the International Tokamak Reactor (INTOR). This paper briefly describes the fuel cycle and safety systems at TSTA including the Vacuum Facility, Fuel Cleanup, Isotope Separation, Transfer Pumping, Emergency Tritium Cleanup, Tritium Waste Treatment, Tritium Monitoring, Data Acquisition and Control, Emergency Power and Gas Analysis systems. Discussed in further detail is the experimental program proposed for the startup and testing of these systems

  18. Tendon vibration attenuates superficial venous vessel response of the resting limb during static arm exercise

    Directory of Open Access Journals (Sweden)

    Ooue Anna

    2012-11-01

    Full Text Available Abstract Background The superficial vein of the resting limb constricts sympathetically during exercise. Central command is the one of the neural mechanisms that controls the cardiovascular response to exercise. However, it is not clear whether central command contributes to venous vessel response during exercise. Tendon vibration during static elbow flexion causes primary muscle spindle afferents, such that a lower central command is required to achieve a given force without altering muscle force. The purpose of this study was therefore to investigate whether a reduction in central command during static exercise with tendon vibration influences the superficial venous vessel response in the resting limb. Methods Eleven subjects performed static elbow flexion at 35% of maximal voluntary contraction with (EX + VIB and without (EX vibration of the biceps brachii tendon. The heart rate, mean arterial pressure, and rating of perceived exertion (RPE in overall and exercising muscle were measured. The cross-sectional area (CSAvein and blood velocity of the basilic vein in the resting upper arm were assessed by ultrasound, and blood flow (BFvein was calculated using both variables. Results Muscle tension during exercise was similar between EX and EX + VIB. However, RPEs at EX + VIB were lower than those at EX (P P vein in the resting limb at EX decreased during exercise from baseline (P vein at EX + VIB did not change during exercise. CSAvein during exercise at EX was smaller than that at EX + VIB (P vein did not change during the protocol under either condition. The decreases in circulatory response and RPEs during EX + VIB, despite identical muscle tension, showed that activation of central command was less during EX + VIB than during EX. Abolishment of the decrease in CSAvein during exercise at EX + VIB may thus have been caused by a lower level of central command at EX + VIB rather than EX. Conclusion Diminished central command induced by tendon

  19. Comparative study of radiation, chemical, and aging effects on viral transformation. Annual progress report, 1975

    Energy Technology Data Exchange (ETDEWEB)

    Coggin, J.H. Jr.

    1976-03-31

    Progress is reported on the following research projects: evaluation of isotopic antiglobulin test (IAT) to detect tumor associated antigens using antisera induced by x-irradiated tumor cells; development of cytotoxic antibody for embryonic antigens (EA); acrylamide gel cell culture assay for transformation; and evaluation of 3-MCA induced sarcomas for TSTA and cross-reacting antigens. (HLW)

  20. Overview of tritium processing development at the tritium systems test assembly

    International Nuclear Information System (INIS)

    Anderson, J.L.

    1986-01-01

    The Tritium Systems Test Assembly (TSTA) at the Los Alamos National Laboratory has been operating with tritium since June 1984. Presently there are some 50 g of tritium in the main processing loop. This 50 g has been sufficient to do a number of experiments involving the cryogenic distillation isotope separation system and to integrate the fuel cleanup system into the main fuel processing loop. In January 1986 two major experiments were conducted. During these experiments the fuel cleanup system was integrated, through the transfer pumping system, with the isotope separation system, thus permitting testing on the integrated fuel processing loop. This integration of these systems leaves only the main vacuum system to be integrated into the TSTA fuel processing loop. In September 1986 another major tritium experiment was performed in which the integrated loop was operated, the tritium inventory increased to 50 g and additional measurements on the performance of the distillation system were taken. In the period June 1984 through September 1986 the TSTA system has processed well over 10 8 Ci of tritium. Total tritium emissions to the environment over this period have been less than 15 Ci. Personnel exposures during this period have totaled less than 100 person-mRem. To date, the development of tritium technology at TSTA has proceeded in progressive and orderly steps. In two years of operation with tritium, no major design flows have been uncovered

  1. US blanket technology programs

    International Nuclear Information System (INIS)

    Nygren, R.E.

    1985-01-01

    Experimental research in US programs related to blanket technology is described through brief summaries of the objectives, facilities, recent experimental results and principal investigators for the Blanket Technology Program, TRIO-1 Experiment, TSTA, Fusion Hybrid Program and selected activities in the Fusion Materials and Fusion Safety Programs in neutronics research

  2. Comparative study of radiation, chemical, and aging effects on viral transformation. Annual progress report, 1975

    International Nuclear Information System (INIS)

    Coggin, J.H. Jr.

    1976-01-01

    Progress is reported on the following research projects: evaluation of isotopic antiglobulin test (IAT) to detect tumor associated antigens using antisera induced by x-irradiated tumor cells; development of cytotoxic antibody for embryonic antigens (EA); acrylamide gel cell culture assay for transformation; and evaluation of 3-MCA induced sarcomas for TSTA and cross-reacting antigens

  3. A titratable two-step transcriptional amplification strategy for targeted gene therapy based on ligand-induced intramolecular folding of a mutant human estrogen receptor

    DEFF Research Database (Denmark)

    Chen, Ian Y; Paulmurugan, Ramasamy; Nielsen, Carsten Haagen

    2014-01-01

    firefly luciferase reporter gene (fluc) depends on the binding of its mutant estrogen receptor (ER(G521T)) ligand binding domain (LBD) to an ER ligand such as raloxifene. Mice underwent either intramyocardial or hydrodynamic tail vein (HTV) injection of pcTnT-tTSTA-fluc, followed by differential...

  4. Salmonellabakter räsib Talleggi / Kristina Traks

    Index Scriptorium Estoniae

    Traks, Kristina, 1976-

    2005-01-01

    Eesti suurimat linnulihatootjat Talleggi võib seoses salmonelloosi levikuga tabada miljonitesse kroonidesse ulatuv kahju ja ligi 30 000 kroonine rahatrahv. Diagramm: Tallegg vajus mullu kahjumisse. Lisa: Salmonella-bakter hävib kuumutades

  5. Business Model Canvas & Elevator pitch : 29-10-2013

    NARCIS (Netherlands)

    Eelco Bakker

    2013-01-01

    Presentatie bij de Workshop Business Model Canvas: de bouwstenen en het gebouw van de onderneming - workshopprogramma ViB050. In het kader van het programma Teach the Teacher. Gehouden op 29-10-2013..

  6. Whole-Body-Vibration Training and Balance in Recreational Athletes With Chronic Ankle Instability.

    Science.gov (United States)

    Sierra-Guzmán, Rafael; Jiménez-Diaz, Fernando; Ramírez, Carlos; Esteban, Paula; Abián-Vicén, Javier

    2018-03-23

      Deficits in the propioceptive system of the ankle contribute to chronic ankle instability (CAI). Recently, whole-body-vibration training has been introduced as a preventive and rehabilitative tool.   To evaluate how a 6-week WBV training program on an unstable surface affected balance and body composition in recreational athletes with CAI.   Randomized controlled clinical trial.   Research laboratory.   Fifty recreational athletes with self-reported CAI were randomly assigned to a vibration (VIB), nonvibration (NVIB), or control group.   The VIB and NVIB groups performed unilateral balance training on a BOSU 3 times weekly for 6 weeks. The VIB group trained on a vibration platform, and the NVIB group trained on the floor.   We assessed balance using the Biodex Balance System and the Star Excursion Balance Test (SEBT). Body composition was measured by dual-energy x-ray absorptiometry.   After 6 weeks of training, improvements on the Biodex Balance System occurred only on the Overall Stability Index ( P = .01) and Anterior-Posterior Stability Index ( P = .03) in the VIB group. We observed better performance in the medial ( P = .008) and posterolateral ( P = .04) directions and composite score of the SEBT in the VIB group ( P = .01) and in the medial ( P Balance System, whereas the VIB and NVIB groups displayed better performance on the SEBT.

  7. Use of Valtrac™-Secured Intracolonic Bypass in Laparoscopic Rectal Cancer Resection

    Science.gov (United States)

    Ye, Feng; Chen, Dong; Wang, Danyang; Lin, Jianjiang; Zheng, Shusen

    2014-01-01

    Abstract The occurrence of anastomotic leakage (AL) remains a major concern in the early postoperative stage. Because of the relatively high morbidity and mortality of AL in patients with laparoscopic low rectal cancer who receive an anterior resection, a fecal diverting method is usually introduced. The Valtrac™-secured intracolonic bypass (VIB) was used in open rectal resection, and played a role of protecting the anastomotic site. This study was designed to assess the efficacy and safety of the VIB in protecting laparoscopic low rectal anastomosis and to compare the efficacy and complications of VIB with those of loop ileostomy (LI). Medical records of the 43 patients with rectal cancer who underwent elective laparoscopic low anterior resection and received VIB procedure or LI between May 2011 and May 2013 were retrospectively analyzed, including the patients’ demographics, clinical features, and operative data. Twenty-four patients received a VIB and 19 patients a LI procedure. Most of the demographics and clinical features of the groups, including Dukes stages, were similar. However, the median distance of the tumor edge from the anus verge in the VIB group was significantly longer (7.5 cm; inter-quartile range [IQR] 7.0–9.5 cm) than that of the L1 group (6.0 cm; IQR 6.0–7.0 cm). None of the patients developed clinical AL. The comparisons between the LI and the VIB groups were adjusted for the significant differences in the tumor level of the groups. After adjustment, the LI group experienced longer overall postoperative hospital stay (14.0 days, IQR: 12.0, 16.0 days; P resection, appears to be a safe and effective, but time-limited, diverting technique to protect an elective low colorectal anastomosis. PMID:25546660

  8. Columbus AFB, Mississippi. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F.

    Science.gov (United States)

    1982-02-16

    sand, and dust. Continued on Reverse A-1 . q .... : . wmJmh,, .,,,-oY Blowing spray - This item if reported, is not shown in a separate category on...BRANCH 6SAFETAC CEILING VERSUS VISIBILITY AT9 ,EATHER SERVICE/MAC 72-3,.6 COLUMBUS AF8 MS 70,73-81 JAN tVAVS~T *tSTA- NAWU OAD PERCENTAGE FREQUENCY OF

  9. A Three-Dimensional Index for Characterizing Crop Water Stress

    Directory of Open Access Journals (Sweden)

    Jessica A. Torrion

    2014-05-01

    Full Text Available The application of remotely sensed estimates of canopy minus air temperature (Tc-Ta for detecting crop water stress can be limited in semi-arid regions, because of the lack of full ground cover (GC at water-critical crop stages. Thus, soil background may restrict water stress interpretation by thermal remote sensing. For partial GC, the combination of plant canopy temperature and surrounding soil temperature in an image pixel is expressed as surface temperature (Ts. Soil brightness (SB for an image scene varies with surface soil moisture. This study evaluates SB, GC and Ts-Ta and determines a fusion approach to assess crop water stress. The study was conducted (2007 and 2008 on a commercial scale, center pivot irrigated research site in the Texas High Plains. High-resolution aircraft-based imagery (red, near-infrared and thermal was acquired on clear days. The GC and SB were derived using the Perpendicular Vegetation Index approach. The Ts-Ta was derived using an array of ground Ts sensors, thermal imagery and weather station air temperature. The Ts-Ta, GC and SB were fused using the hue, saturation, intensity method, respectively. Results showed that this method can be used to assess water stress in reference to the differential irrigation plots and corresponding yield without the use of additional energy balance calculation for water stress in partial GC conditions.

  10. Õiglane maailm / Riina Luik

    Index Scriptorium Estoniae

    Luik, Riina, 1962-

    2008-01-01

    Õiglase kaubanduse toodete tarbimine maailmas kasvas 2007. aastal 47 %. Õiglase kaubanduse süsteemi sünniloost, arengust ja toodetest, Fairtrade'i kaupade tarbimisest ja kaubamärgi tuntusest Eestis. Arvamust avaldavad: Riina Kuusik, Mairika Juhandi, Anne Harak, Kätlin Rohilaid, Jaanus Vernik, Riina Pärnpuu, Ave Oit, Siret Shalamov. Lisad: Õiglane kaubandus maailmas; Käi õiges poes!; Eestis müüdavad Fairtrade'i tooted; The Body Shop

  11. Tendon vibration attenuates superficial venous vessel response of the resting limb during static arm exercise.

    Science.gov (United States)

    Ooue, Anna; Sato, Kohei; Hirasawa, Ai; Sadamoto, Tomoko

    2012-11-07

    The superficial vein of the resting limb constricts sympathetically during exercise. Central command is the one of the neural mechanisms that controls the cardiovascular response to exercise. However, it is not clear whether central command contributes to venous vessel response during exercise. Tendon vibration during static elbow flexion causes primary muscle spindle afferents, such that a lower central command is required to achieve a given force without altering muscle force. The purpose of this study was therefore to investigate whether a reduction in central command during static exercise with tendon vibration influences the superficial venous vessel response in the resting limb. Eleven subjects performed static elbow flexion at 35% of maximal voluntary contraction with (EX + VIB) and without (EX) vibration of the biceps brachii tendon. The heart rate, mean arterial pressure, and rating of perceived exertion (RPE) in overall and exercising muscle were measured. The cross-sectional area (CSAvein) and blood velocity of the basilic vein in the resting upper arm were assessed by ultrasound, and blood flow (BFvein) was calculated using both variables. Muscle tension during exercise was similar between EX and EX + VIB. However, RPEs at EX + VIB were lower than those at EX (P tension, showed that activation of central command was less during EX + VIB than during EX. Abolishment of the decrease in CSAvein during exercise at EX + VIB may thus have been caused by a lower level of central command at EX + VIB rather than EX. Diminished central command induced by tendon vibration may attenuate the superficial venous vessel response of the resting limb during sustained static arm exercise.

  12. The Virtual Insect Brain protocol: creating and comparing standardized neuroanatomy

    Directory of Open Access Journals (Sweden)

    Schindelin Johannes E

    2006-12-01

    Full Text Available Abstract Background In the fly Drosophila melanogaster, new genetic, physiological, molecular and behavioral techniques for the functional analysis of the brain are rapidly accumulating. These diverse investigations on the function of the insect brain use gene expression patterns that can be visualized and provide the means for manipulating groups of neurons as a common ground. To take advantage of these patterns one needs to know their typical anatomy. Results This paper describes the Virtual Insect Brain (VIB protocol, a script suite for the quantitative assessment, comparison, and presentation of neuroanatomical data. It is based on the 3D-reconstruction and visualization software Amira, version 3.x (Mercury Inc. 1. Besides its backbone, a standardization procedure which aligns individual 3D images (series of virtual sections obtained by confocal microscopy to a common coordinate system and computes average intensities for each voxel (volume pixel the VIB protocol provides an elaborate data management system for data administration. The VIB protocol facilitates direct comparison of gene expression patterns and describes their interindividual variability. It provides volumetry of brain regions and helps to characterize the phenotypes of brain structure mutants. Using the VIB protocol does not require any programming skills since all operations are carried out at an intuitively usable graphical user interface. Although the VIB protocol has been developed for the standardization of Drosophila neuroanatomy, the program structure can be used for the standardization of other 3D structures as well. Conclusion Standardizing brains and gene expression patterns is a new approach to biological shape and its variability. The VIB protocol provides a first set of tools supporting this endeavor in Drosophila. The script suite is freely available at http://www.neurofly.de2

  13. An International Survey of Shock and Vibration Technology

    Science.gov (United States)

    1979-03-01

    and certain musical instruments. The human eardrum is a membrane. Membranes are also extensively used in machine design for such items as pumps...Film Bearings", J. Sound Vib., 35 (3), pp 361-377, (Aug. 8, 1974). 434. Parkinson , A.G., "The Modal Interpretation of the Vibration of a Damped...D.L. and Swallow, J.C., "Annoying Floor Vibrations--Diagnosis and Therapy ", Sound Vib. 9 (3), pp 12-17 (Mar. 1975). 496. Leipholz, H.H.E., "Aspects

  14. Failure Analysis of Electrical Pin Connectors

    Science.gov (United States)

    Newman, John A.; Baughman, James M.; Smith, Stephen W.; Herath, Jeffrey A.

    2008-01-01

    A study was initiated to determine the root cause of failure for circuit board electrical connection pins that failed during vibRatory testing. The circuit board is part of an unmanned space probe, and the vibratory testing was performed to ensure component survival of launch loading conditions. The results of this study show that the pins failed as a result of fatigue loading.

  15. Music for the Handicapped.

    Science.gov (United States)

    Mercado, Aurea A.

    This report is an evaluation of a New York City school district educational project funded under Title VIB Education of the Handicapped Act. Under the direction of a project coordinator and a music therapist, 365 emotionally disturbed, hyperactive, and mentally retarded youngsters, ranging in age from 6 to 15, participated in the program. Primary…

  16. Discharge Modes Suggested by Emission Spectra of Nitrogen Dielectric Barrier Discharge with Wire-Cylinder Electrodes

    International Nuclear Information System (INIS)

    Yang Fuxiang; Mu Zongxin; Zhang Jialiang

    2016-01-01

    In this paper, nitrogen dielectric barrier discharge (DBD) plasma was generated in a quartz tube with coaxial wire-cylinder electrodes at atmospheric pressure. By varying the nitrogen gas flow (F N ) in the range of 0-1 m 3 /h, the plasma optical emission spectra (OES) were measured and studied. The vibration (T vib ) and rotation temperature (T rot ) of nitrogen were obtained, by fitting the rovibronic bands of N 2 (C 3 Π u – B 3 Π g , 0-1), and by the Boltzmann plot method for purposes of comparison. T vib increased up to 2481 K with increasing nitrogen flow till 0.2 m 3 /h, and then decreased with further increasing F N , while T rot decreased monotonously and approached to ∼350 K for F N ≥ 0.6 m 3 /h. The intensity of N 2 (C 3 Π u – B 3 Π g , 0-0, 1-0, 0-3) and N 2 + (B 2 Σ u + – X 2 Σ + g , 0-0) exhibited similar evolution with increasing F N to those of the T vib and T rot , respectively. The discharge photos revealed that the discharge filaments gradually decreased with increasing F N , and eventually disappeared, which implied that a discharge mode transition emerged with increasing F N . The possible mechanism for the discharge mode transition is studied in detail according to the vibration (T vib ) and rotation temperature (T rot ) of nitrogen. (paper)

  17. A series of poly(butylimidazolium) ionic liquid functionalized copolymers for anion exchange membranes

    Science.gov (United States)

    Ouadah, Amina; Xu, Hulin; Luo, Tianwei; Gao, Shuitao; Wang, Xing; Fang, Zhou; Jing, Chaojun; Zhu, Changjin

    2017-12-01

    A new series of ionic liquid functionalized copolymers for anion exchange membranes (AEM) is prepared. Poly(butylvinylimidazolium)(b-VIB) is copolymerized with para-methyl styrene (p-MS) by the radical polymerization formed block copolymers b-VIB/p-MS, which is crosslinked with poly(diphenylether bibenzimidazole) (DPEBI) providing the desired materials b-VIB/p-MS/DPEBI. Structures are characterized via H1NMR, FTIR spectra and elemental analysis. The b-VIB blocks offer the anion conduction function while DPEBI moieties contribute to enhancing other properties. The prepared membranes display chloride conductivity as high as 19.5 mS/cm at 25 °C and 69.2 mS/cm at 100 °C-higher than that of the commercial membrane tokuyuama A201-. Their hydroxide conductivity reaches 35.7 Scm-1 at 25 °C and 73.1 Scm-1 at 100 °C. The membranes showed a linear Arrhenius behavior in the anion conduction, low activation energies and distinguished nanophase separation of hydrophilic/hydrophobic regions by the transmission electron microscopy (TEM) studies. Thermal investigations using TGA and DSC confirm that the membranes are stable up to 250 °C. Particularly, drastically alkaline stability due to no decrease in the hydroxide conductivity after 168 h of treatment with 2M KOH.

  18. Isolation of a cytolytic component from naja nigricollis nigricollis ...

    African Journals Online (AJOL)

    It is partially pure as indicated by SDS-PAGE, with molecular weight approximately 10 kDa. It has no protease or phospholipase activity. It is a ... Small doses of VIb induced lysis in breast, colon and hepatocellular carcinomas cell lines in tissue culture plates. Keywords: Naja cytotoxin, Hemolytic, Cytolysis, malignant cells ...

  19. Elucidation of the Vibrio anguillarum genetic response to the potential fish probiont Pseudomonas fluorescens AH2, using RNA-arbitrarily primed PCR

    DEFF Research Database (Denmark)

    Holmstrøm, Kim; Gram, Lone

    2003-01-01

    with the iron chelator 2,2-dipyridyl. A chromosomal transcript homologous to vibE that participates in vibriobactin synthesis in Vibrio cholerae was also upregulated during AH2 exposure. This transcript could represent a functionally active gene in V. anguillarum involved in biosynthesis of anguibactin...

  20. Lithium-Sulfur Dioxide (Li/SO2) Battery Safety Hazards - Thermal Studies.

    Science.gov (United States)

    1982-03-01

    Cathode Potential 0.0 volts versus Li) FREQUENCY (cm ’I I NTENSITY ASSTI NXMNNT 3975 M OH gp Vib of watcr attached to L. 3660 K Oil gp Vjbr of water 3620...Discharge", Proceedings of the Symposia on Power Sources for Biomedical Implatable Applications and Ambient Temperature Lithium Batteries, 80-4, 570

  1. Ondernemersplan workshop

    NARCIS (Netherlands)

    Jacques Hartog

    2013-01-01

    Workshop over tips & tricks voor een goed plan - Serie Startup Academy., gehouden op 28-05-2013. Workshopprogramma Value in Business, ViB050. Binnen het CVO Groningen stimuleert het Groningen Center of Enterpreneurship Value050 valorisatie door het ontwikkelen en ondersteunen van ondernemerschap en

  2. 40 CFR 763.85 - Inspection and reinspections.

    Science.gov (United States)

    2010-07-01

    ... paragraph (a)(4)(vi)(B) of this section, are surfacing material, thermal system insulation, or miscellaneous... accreditation number. (c) General. Thermal system insulation that has retained its structural integrity and that... CONTROL ACT ASBESTOS Asbestos-Containing Materials in Schools § 763.85 Inspection and reinspections. (a...

  3. 75 FR 42342 - Approval and Disapproval and Promulgation of Air Quality Implementation Plans; Colorado...

    Science.gov (United States)

    2010-07-21

    ... modifies the method for calculating compliance with emission limits for petroleum refining and cement... method of computing compliance with emission limits for cement manufacturing and petroleum refining....4.e) and refining oil produced from shale (Section VI.B.4.g(ii)). The State revised the daily limit...

  4. 76 FR 4540 - Approval and Disapproval and Promulgation of Air Quality Implementation Plans; Colorado...

    Science.gov (United States)

    2011-01-26

    ... modifies the method for calculating compliance with emission limits for petroleum refining and cement... petroleum and oil shale refining; (4) revisions to Section VI.B.5 regarding SO 2 emission limits for new... on public health or welfare. The State revised the method in Section III.A.1.d for calculating...

  5. Untitled

    Indian Academy of Sciences (India)

    Kant S, Munjal M L, Rao D LP 1974 Waves in branched hydraulic pipes. J. Sound Vib. 37: 507-519. Kakoty S K 1989 Bulk reaction modelling of lined ducts with and without mean flow, M E dissertation,. Indian Institute of Science, Bangalore. Kathuriya M. L., Munjai Mil 1975 An accurate method for the experimental ...

  6. Effect of bimodularity on frequency response of cylindrical panels ...

    Indian Academy of Sciences (India)

    M. Senthilkumar (Newgen Imaging) 1461 1996 Oct 15 13:05:22

    Doong J L, Fung C P 1988 Vibration and buckling of bimodulus laminated plates according to a higher-order plate theory. J. Sound Vib. 125: 325–339. Khan K, Patel B P, Nath Y 2007 Free vibration of bimodulus laminated angle-ply cylindrical panels,. Proceedings of the 4th International Conference on Theoritical, Applied, ...

  7. Untitled

    Indian Academy of Sciences (India)

    Huseyin K, Wang S 1991 An extension of the intrinsic harmonic balancing method to the analysis of forced vibration. J. Sound Vib. 148: 361-363. Ide K, Wiggins S 1989 The bifurcation to homoclinictori in the quasiperiodically forced Duffing oscillator. Physica D34: 169-182. Iooss G, Joseph DD 1980 Elementary stability and ...

  8. Sensing Applied Load and Damage Effects in Composites with Nondestructive Techniques

    Science.gov (United States)

    2017-05-01

    ray absorption to illuminate damage on the images.27,30 2.4 Testing Procedure Testing on all coupons begins with static loading, which progresses...composite structures: a review. J Sound Vib. 2006;295(3–5):753–780. 31. Williams WB, Michaels TE, Michaels JE. Characterization of guided wave velocity

  9. 21 CFR 173.65 - Divinylbenzene copolymer.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Divinylbenzene copolymer. 173.65 Section 173.65 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD... with food only of Types I, II, and VI-B (excluding carbonated beverages) described in table 1 of...

  10. Active Noise and Vibration Control Literature Survey: Sensors and Actuators

    Science.gov (United States)

    1999-08-01

    changes the simple monopole source to a less efficient dipole . The use of a second control source at the duct exit has been investigated by Trinder...noise attenuator. J. Sound Vib., 110, 471-481. 7.8 Electromagnetic Actuators Lecoufle, J.C. (1987): Actionneurs electriques industriels : technologie et

  11. People’s Republic of China Scientific Abstracts, Number 168.

    Science.gov (United States)

    1977-06-02

    Sciences Received 1 August 1975 AUTHOR: None ORG: Department of Phytochemistry , Institute of Materia Medica, Chinese Academy of Medical Sciences...reaction steps involved in this syn- thesis were the use of the 15-methyl-containing aluminum compound (IV^) as a reagent to prepare VIb(R3=H), and

  12. Raman study of vibrational dephasing in liquid CH3CN and CD3CN

    International Nuclear Information System (INIS)

    Schroeder, J.; Schiemann, V.H.; Sharko, P.T.; Jonas, J.

    1977-01-01

    The Raman line shapes of the ν 1 (a 1 ) C--H and C--D fundamentals in liquid acetonitrile and acetonitrile-d 3 have been measured as a function of pressure up to 4 kbar within the temperature interval 30--120 degreeC. Densities have also been determined. From the isotropic component of the vibrational Raman band shape the vibrational relaxation times have been obtained as a function of temperature and pressure (density). The experimental results can be summarized as follows: (i) as T increases at constant density rho, the vibrational relaxation rate (tau/sub vib/) -1 increases; (ii) at constant T as density is raised tau/sub vib/ -1 increases; (iii) at constant pressure the T increase produces higher tau/sub vib/ -1 , however, the change is more pronounced for the CD 3 CN liquid. Isotopic dilution studies of the CH 3 CN/CD 3 CN mixtures shows no significant effect on (tau/sub vib/ -1 ). The experimental data are interpreted in terms of the Kubo stochastic line shape theory and the dephasing model of Fischer and Laubereau. The results based on Kubo formalism indicate that dephasing is the dominant relaxation mechanism and that the modulation is fast. The isolated binary collision model proposed by Fischer and Laubereau for vibrational dephasing reproduces the essential features of the density and temperature dependence of the (tau/sub vib/) -1 and suggests that pure dephasing is the dominant broadening mechanism for the isotropic line shapes studied. In the calculation the elastic collision times were approximated by the Enskog relaxation times

  13. Software design for the Tritium System Test Assembly

    International Nuclear Information System (INIS)

    Claborn, G.W.; Heaphy, R.T.; Lewis, P.S.; Mann, L.W.; Nielson, C.W.

    1983-01-01

    The control system for the Tritium Systems Test Assembly (TSTA) must execute complicated algorithms for the control of several sophisticated subsystems. It must implement this control with requirements for easy modifiability, for high availability, and provide stringent protection for personnel and the environment. Software techniques used to deal with these requirements are described, including modularization based on the structure of the physical systems, a two-level hierarchy of concurrency, a dynamically modifiable man-machine interface, and a specification and documentation language based on a computerized form of structured flowcharts

  14. Development of a quality-assurance program for the Tritium Systems Test Assembly

    International Nuclear Information System (INIS)

    Minor, R.C.

    1981-01-01

    A quality assurance program was developed for TSTA with the attempt in mind to satisfy the developmental nature of the project. Numerous reviews replace strict guidelines because guidelines are one of the objectives of the project, not a basis for it. The reviews assure adequate technical consideration and avoid unilateral decisions. Other major requirements of the program plan include interfacing with another quality assurance organization, the assignment of responsibilities, and instructions for the preparation of SDD's. Areas of concern are, in general, budget related, and include receiving inspection and acceptance of items. A software program is only now being established

  15. Indirect imaging of cardiac-specific transgene expression using a bidirectional two-step transcriptional amplification strategy

    DEFF Research Database (Denmark)

    Chen, I Y; Gheysens, O; Ray, S

    2010-01-01

    in a cardiac cell line and the myocardium, while minimizing expression in non-cardiac cell lines and the liver. In vitro, the TSTA system significantly enhanced cTnT-mediated reporter gene expression with moderate preservation of cardiac specificity. After intramyocardial and hydrodynamic tail vein delivery...... genes, firefly luciferase (fluc) and Renilla luciferase (hrluc), driven by the cardiac troponin T (cTnT) promoter. The vector was characterized in vitro and in living mice using luminometry and bioluminescence imaging to assess its ability to mediate strong, correlated reporter gene expression...

  16. Overview of tritium systems for the Compact Ignition Tokamak

    International Nuclear Information System (INIS)

    Bartlit, J.R.; Gruetzmacher, K.M.; Fleming, R.B.

    1987-01-01

    The Compact Ignition Tokamak (CIT) is being designed at several laboratories to produce and study fully ignited plasma discharges. The tritium systems which will be needed for CIT include fueling systems and radiation monitoring and safety systems. Design of the tritium systems is the responsibility of the Tritium Systems Test Assembly (TSTA) at Los Alamos National Laboratory. Major new tritium systems for CIT include a pellet injector, an air detritiation system and a glovebox atmosphere detritiation system. The pellet injector is being developed at Oak Ridge National Laboratory. 7 refs., 2 figs

  17. Preliminary design of fusion reactor fuel cleanup system by palladium alloy membrane method

    International Nuclear Information System (INIS)

    Yoshida, Hiroshi; Konishi, Satoshi; Naruse, Yuji

    1981-10-01

    A design of palladium diffuser and Fuel Cleanup System (FCU) for D-T fusion reactor is proposed. Feasibility of palladium alloy membrane method is discussed based on the early studies by the authors. Operating conditions of the palladium diffuser are determined experimentally. Dimensions of the diffuser are estimated from computer simulation. FCU system is designed under the feed conditions of Tritium Systems Test Assembly (TSTA) at Los Alamos Scientific Laboratory. The system is composed of Pd-diffusers, catalytic oxidizer, freezer and zink beds, and has some advantages in system layout and operation. This design can readily be extended to other conditions of plasma exhaust gases. (author)

  18. Osoon kaitseb kõrvetava päikese eest / Valentina Laius ; interv. Agnes Jürgens

    Index Scriptorium Estoniae

    Laius, Valentina

    2007-01-01

    Vt. ka Severnoje Poberezhje 31. mai, Meie Maa 4. juuni ; Hiiu Leht : Hiiumaa Looduse Leht ; Valgamaalane 5. juuni, Koit 7. juuni., Lääne Elu 9. juuni, Oma Saar 12. juuni, Koit : Keskkond 5. juuli, Vooremaa : Jõgevamaa Keskkonnaleht 7. juuli, Järvamaa Teataja : Järvamaa Keskkonnaleht 12. juuli, Valgamaalane : Valgamaa Keskkonnaleht 27. sept., Sakala : Viljandimaa Keskkond 28. sept., Tartu Postimees : Keskkonnaleht 3. okt. Elu Maal ei saa kesta ilma atmosfääri ehk maakera ümbritseva õhkkonnata. Maavarade kasutamine, keerulised tootmisprotsessid, sõidukid ja ulatuslik fossiilsete kütuste tarbimine on atmosfääri koostist kiiresti muutmas. Ühe abinõuna võitlemisel atmosfäärimuutuset vastu soovitavad teadlased kaitsta maakera ümbritsevat osoonikihti. Vestlus keskkonnaministeeriumi välisõhu ja kiirgusohutuse büroo peaspetsialistiga

  19. Säästva arengu indikaatorid Eesti ja Läänemerepiirkonna tööstussektoris / Eva Liivak

    Index Scriptorium Estoniae

    Liivak, Eva

    2004-01-01

    Tartu Ülikoolis koostati 2004. a. Baltic 21 Institute for Sustainable Industry projekti raames Eesti ja teiste Läänemeremaade tööstussektorit käsitlev säästva arengu indikaatorite ülevaade. Joonised: Tööstustoodangu muutus Eestis 1993-2002; Tööstustoodangu muutus mõnes Läänemere regiooni riigis 1995-2000; Elektrienergia tarbimine Eestis 1994-2002; Elektrienergia tarbimise muutus mõnes Läänemere regiooni riigis 1995-2000; Tööõnnetused Eestis 1995-2002; Rasked tööõnnetused mõnes Läänemere regiooni riigis 2001. aastal

  20. Tritium behavior intentionally released in the room

    International Nuclear Information System (INIS)

    Kobayashi, K.; Hayashi, T.; Iwai, Y.; Yamanishi, T.; Willms, R. S.; Carlson, R. V.

    2008-01-01

    To construct a fusion reactor with high safety and acceptability, it is necessary to establish and to ensure tritium safe handling technology. Tritium should be well-controlled not to be released to the environment excessively and to prevent workers from excess exposure. It is especially important to grasp tritium behavior in the final confinement area, such as the room and/or building. In order to obtain data for actual tritium behavior in a room and/or building, a series of intentional Tritium Release Experiments (TREs) were planned and carried out within a radiologically controlled area (main cell) at Tritium System Test Assembly (TSTA) in Los Alamos National Laboratory (LANL) under US-JAPAN collaboration program. These experiments were carried out three times. In these experiments, influence of a difference in the tritium release point and the amount of hydrogen isotope for the initial tritium behavior in the room were suggested. Tritium was released into the main cell at TSTA/LANL. The released tritium reached a uniform concentration about 30 - 40 minutes in all the experiments. The influence of the release point and the amount of hydrogen isotope were not found to be important in these experiments. The experimental results for the initial tritium behavior in the room were also simulated well by the modified three-dimensional eddy flow analysis code FLOW-3D. (authors)

  1. Differential effects of continuous theta burst stimulation over left premotor cortex and right prefrontal cortex on modulating upper limb somatosensory input.

    Science.gov (United States)

    Brown, Matt J N; Staines, W Richard

    2016-02-15

    Somatosensory evoked potentials (SEPs) represent somatosensory processing in non-primary motor areas (i.e. frontal N30 and N60) and somatosensory cortices (i.e. parietal P50). It is well-known that the premotor cortex (PMC) and prefrontal cortex (PFC) are involved in the preparation and planning of upper limb movements but it is currently unclear how they modulate somatosensory processing for upper limb motor control. In the current study, two experiments examined SEP modulations after continuous theta burst stimulation (cTBS) was used to transiently disrupt the left PMC (Experiment 1) and right PFC (Experiment 2). Both Experiment 1 (n=15) and Experiment 2 (n=16) used pre-post experimental designs. In both experiments participants performed a task requiring detection of varying amplitudes of attended vibrotactile (VibT) stimuli to the left index finger (D2) and execution of a pre-matched finger sequence with the right (contralateral) hand to specific VibT targets. During the task, SEPs were measured to median nerve (MN) stimulations time-locked during pre-stimulus (250 ms before VibT), early response selection (250 ms after VibT), late preparatory (750 ms after VibT) and execution (1250 ms VibT) phases. The key findings of Experiment 1 revealed significant decreases in N30 and N60 peak amplitudes after cTBS to PMC. In contrast, the results of Experiment 2, also found significant decreased N60 peak amplitudes as well as trends for increased N30 and P50 peak amplitudes. A direct comparison of Experiment 1 and Experiment 2 confirmed differential modulation of N30 peak amplitudes after PMC (gated) compared to PFC (enhanced) cTBS. Collectively, these results support that both the left PMC and right PFC have modulatory roles on early somatosensory input into non-primary motor areas, such as PMC and supplementary motor area (SMA), represented by frontal N30 and N60 SEPs. These results confirm that PMC and PFC are both part of a network that regulates somatosensory input

  2. Intermittent whole-body vibration attenuates a reduction in the number of the capillaries in unloaded rat skeletal muscle.

    Science.gov (United States)

    Kaneguchi, Akinori; Ozawa, Junya; Kawamata, Seiichi; Kurose, Tomoyuki; Yamaoka, Kaoru

    2014-09-26

    Whole-body vibration has been suggested for the prevention of muscle mass loss and muscle wasting as an attractive measure for disuse atrophy. This study examined the effects of daily intermittent whole-body vibration and weight bearing during hindlimb suspension on capillary number and muscle atrophy in rat skeletal muscles. Sixty male Wistar rats were randomly divided into four groups: control (CONT), hindlimb suspension (HS), HS + weight bearing (WB), and HS + whole-body vibration (VIB) (n = 15 each). Hindlimb suspension was applied for 2 weeks in HS, HS + WB, and HS + VIB groups. During suspension, rats in HS + VIB group were placed daily on a vibrating whole-body vibration platform for 20 min. In HS + WB group, suspension was interrupted for 20 min/day, allowing weight bearing. Untreated rats were used as controls. Soleus muscle wet weights and muscle fiber cross-sectional areas (CSA) significantly decreased in HS, HS + WB, and HS + VIB groups compared with CONT group. Both muscle weights and CSA were significantly greater in HS + WB and HS + VIB groups compared with HS group. Capillary numbers (represented by capillary-to-muscle fiber ratio) were significantly smaller in all hindlimb suspension-treated groups compared with CONT group. However, a reduction in capillary number by unloading hindlimbs was partially prevented by whole-body vibration. These findings were supported by examining mRNA for angiogenic-related factors. Expression levels of a pro-angiogenic factor, vascular endothelial growth factor-A mRNA, were significantly lower in all hindlimb suspension-treated groups compared with CONT group. There were no differences among hindlimb suspension-treated groups. Expression levels of an anti-angiogenic factor, CD36 (receptor for thrombospondin-1) mRNA, were significantly higher in all hindlimb suspension-treated groups compared with CONT group. Among the hindlimb suspension-treated groups, expression of CD

  3. Communication: Vibrational relaxation of CO(1Σ) in collision with Ar(1S) at temperatures relevant to the hypersonic flight regime.

    Science.gov (United States)

    Denis-Alpizar, Otoniel; Bemish, Raymond J; Meuwly, Markus

    2017-03-21

    Vibrational energy relaxation (VER) of diatomics following collisions with the surrounding medium is an important elementary process for modeling high-temperature gas flow. VER is characterized by two parameters: the vibrational relaxation time τ vib and the state relaxation rates. Here the vibrational relaxation of CO(ν=0←ν=1) in Ar is considered for validating a computational approach to determine the vibrational relaxation time parameter (pτ vib ) using an accurate, fully dimensional potential energy surface. For lower temperatures, comparison with experimental data shows very good agreement whereas at higher temperatures (up to 25 000 K), comparisons with an empirically modified model due to Park confirm its validity for CO in Ar. Additionally, the calculations provide insight into the importance of Δν>1 transitions that are ignored in typical applications of the Landau-Teller framework.

  4. Identification of intracellular phospholipases A2 in the human eye: involvement in phagocytosis of photoreceptor outer segments

    DEFF Research Database (Denmark)

    Kolko, Miriam; Wang, Jinmei; Zhan, Chen

    2007-01-01

    RNA and protein expression of intracellular PLA(2) subtypes in the retinal pigment epithelial cell line ARPE-19. Immunohistochemical staining of normal human eye sections was performed to reveal the cellular location of the enzymes. A model of RPE phagocytosis of POS was used to explore the role of intracellular......, and IVC; and iPLA(2), group VIB, were identified in the human RPE cell line ARPE-19. Furthermore, protein of iPLA(2)-VIA, cPLA(2)-IVA, and iPLA(2)-VIB were identified in ARPE-19 cells and in various parts of the normal human eye. iPLA(2)-VIA protein levels were upregulated during phagocytosis, and iPLA(2...

  5. The Shock and Vibration Digest. Volume 18, Number 10

    Science.gov (United States)

    1986-10-01

    Vibrations and Stability of Multi- ple Parapieter Systems. Sijthoff and Noordhoff (1978). 10. Rouche , N. et al. Stability -nieory...force. S6-1876 Cutting Ptocesa Djmamici Simulation fot Machine Tool Structute Design S.J. Lee , S.G. Kapoor Univ. of Illinois, Champaign-Urbana...S.H. Lee MacNeal-Schwendler Corp., Los Angeles, CA J. Vib,, Acoust., Stress, Rel, Des., Trans. ASM!;, XM (2), pp 222-229 (Apt 1986) 6 figs

  6. The Shock and Vibration Digest. Volume 15, Number 11

    Science.gov (United States)

    1983-11-01

    including turbogenerator rotors, bow behavior, AZ 85018 - (602) 945-4603/946-7333. squeeze - film dampers for turbomachinery, advanced concepts in... squeeze - film J.P. Bandstra dampers . Div. of Engrg. Tech., Univ. of Pittsburgh at Johns- town, Johnstown, PA 15904, J. Vib. Acoust. Stress 4 Rel. Des...analysis; and machinery characteristics. The include gears, bearings (fluid film and antifriction), techniques will be illustrated with case histories

  7. The Shock and Vibration Digest. Volume 13. Number 7

    Science.gov (United States)

    1981-07-01

    Isolation Precision Ma- S/V Sound Vib., 13 (8), p 1823 21. Kishor, B., "Effects of System Parameters and Gear Errors of Drive Train ...incorporate NDT at the design stage, make cost effectiveness studies, prepare and respond to the needs of the general society and train its personnel...Also see No. 1541) 81-1429 Modeling and Dynamic Response of Maglev Vehicle« Subjected to Crouwind Gusts D.P. Garg and T.M. Barrows Duke Univ

  8. The acute effects of stretching with vibration on dynamic flexibility in young female gymnasts.

    Science.gov (United States)

    Johnson, Aaron W; Warcup, Caisa N; Seeley, Matthew K; Eggett, Dennis; Feland, Jeffery B

    2018-01-10

    While stretching with vibration has been shown to improve static flexibility; the effect of stretching with vibration on dynamic flexibility is not well known. The purpose of this study was to examine the effectiveness of stretching with vibration on acute dynamic flexibility and jump height in novice and advanced competitive female gymnasts during a split jump. Female gymnast (n=27, age: 11.5 ± 1.7 years, Junior Olympic levels 5-10) participated in this cross-over study. Dynamic flexibility during gymnastic split jumps were video recorded and analyzed with Dartfish software. All participants completed both randomized stretching protocols with either the vibration platform turned on (VIB) (frequency of 30 Hz and 2 mm amplitude) or off (NoVIB) separated by 48 h. Participants performed 4 sets of three stretches on the vibration platform. Each stretch was held for 30 s with 5 s rest for a total of 7 min of stretch. Split jump flexibility decreased significantly from pre to post measurement in both VIB (-5.8°±5.9°) (pstatic stretching with or without vibration immediately before performance does not alter jump height. Stretching with vibration immediately prior to gymnastics competition decreases split jump flexibility in lower level gymnasts more than upper level gymnasts.

  9. Tritium proof-of-principle injector experiment

    International Nuclear Information System (INIS)

    Fisher, P.W.; Milora, S.L.; Combs, S.K.; Carlson, R.V.; Coffin, D.O.

    1988-01-01

    The Tritium Proof-of-Principle (TPOP) pellet injector was designed and built by Oak Ridge National Laboratory (ORNL) to evaluate the production and acceleration of tritium pellets for fueling future fision reactors. The injector uses the pipe-gun concept to form pellets directly in a short liquid-helium-cooled section of the barrel. Pellets are accelerated by using high-pressure hydrogen supplied from a fast solenoid valve. A versatile, tritium-compatible gas-handling system provides all of the functions needed to operate the gun, including feed gas pressure control and flow control, plus helium separation and preparation of mixtures. These systems are contained in a glovebox for secondary containment of tritium Systems Test Assembly (TSTA) at Los Alamos National Laboratory (LANL). 18 refs., 3 figs

  10. Tritium transport and control in the FED

    International Nuclear Information System (INIS)

    Rogers, M.L.

    1981-01-01

    The tritium systems for the FED have three primary purposes. The first is to provide tritium and deuterium fuel for the reactor. This fuel can be new tritium or deuterium delivered to the plant site, or recycled DT from the reactor that must be processed before it can be recycled. The second purpose of the FED tritium systems is to provide state-of-the-art tritium handling to limit worker radiation exposure and to minimize tritium losses to the environment. The final major objective of the FED tritium systems is to provide an integrated system test of the tritium handling technology necessary to support the fusion reactor program. Every effort is being made to incorporate available information from the Tritium System Test Assembly (TSTA) at Los Alamos National Laboratory, the Tokamak Fusion Test Reactor (TFTR) tritium systems, and the tritium handling information generated within DOE for the past 20 years

  11. Experiments on a ceramic electrolysis cell and a palladium diffuser at the tritium systems test assembly

    International Nuclear Information System (INIS)

    Konishi, Satoshi; Yoshida, Hiroshi; Ohno, Hideo; Naruse, Yuji; Coffin, D.O.; Walthers, C.R.; Binning, K.E.

    1985-01-01

    A ceramic electrolysis cell and a palladium diffuser are developed in Japan and is tested with tritium in Tritium Systems Test Assembly (TSTA) of the Los Alamos National Laboratory, in order to confirm the feasibility as possible upgrades for the fuel cleanup system (PCU). The ceramic electrolysis cell made of stabilized zirconia was operated at 630 0 C for an extended period with a mixture of 3% T 2 O in He carrier gas in the circulation system with oxidizing catalyst bed. The palladium diffuser was tested with circulated pure tritium gas at 280 0 C to verify the compatibility of the alloy with tritium, since the 3 He produced in the metal could cause a degradation. The isotopic effects were also measured for both devices

  12. Short Duration Small Sided Football and to a Lesser Extent Whole Body Vibration Exercise Induce Acute Changes in Markers of Bone Turnover

    Directory of Open Access Journals (Sweden)

    J. L. Bowtell

    2016-01-01

    Full Text Available We aimed to study whether short-duration vibration exercise or football sessions of two different durations acutely changed plasma markers of bone turnover and muscle strain. Inactive premenopausal women (n=56 were randomized to complete a single bout of short (FG15 or long duration (FG60 small sided football or low magnitude whole body vibration training (VIB. Procollagen type 1 amino-terminal propeptide (P1NP was increased during exercise for FG15 (51.6±23.0 to 56.5±22.5 μg·L−1, mean ± SD, P0.05. An increase in osteocalcin was observed 48 h after exercise (P<0.05, which did not differ between exercise groups. C-terminal telopeptide of type 1 collagen was not affected by exercise. Blood lactate concentration increased during exercise for FG15 (0.6±0.2 to 3.4±1.2 mM and FG60 (0.6±0.2 to 3.3±2.0 mM, but not for VIB (0.6±0.2 to 0.8±0.4 mM (P<0.05. Plasma creatine kinase increased by 55±63% and 137±119% 48 h after FG15 and FG60 (P<0.05, but not after VIB (26±54%, NS. In contrast to the minor elevation in osteocalcin in response to a single session of vibration exercise, both short and longer durations of small sided football acutely increased plasma P1NP, osteocalcin, and creatine kinase. This may contribute to favorable effects of chronic training on musculoskeletal health.

  13. Influence of Whole Body Vibration and Specific Warm-ups on Force during an Isometric Mid-Thigh Pull

    Directory of Open Access Journals (Sweden)

    Vanessa L. Cazás-Moreno

    2015-10-01

    Full Text Available Purpose: The purpose of this study was to investigate the effects of general and specific warm-up protocols on rate of force development (RFD, relative RFD (rRFD, ground reaction force (GRF and relative ground reaction force (rGRF during an isometric mid-thigh pull (IMTP, after WBV exposure. Methods: Fifteen healthy recreationally trained males  (age: 24.1 ± 2.3 yrs, height: 72.9 ± 7.8 cm; mass: 86.9 ± 8.3 completed five protocols: baseline, isometric vibration (iVib, isometric no vibration (iNV, dynamic vibration (dVib and dynamic no vibration (dNV. The baseline was completed without any warm-up prior to the IMTP. The intervention protocols had the same prescription of 4 sets of 30-second bouts of quarter squats (dynamic [DQS] and isometric [IQS] on the WBV platform with or without vibration. Following a one-minute rest period after each protocol, participants completed three maximal IMTPs. Results: Repeated measures ANOVA with a Bonferroni post hoc demonstrated that RFD in dNV (7657.8 ± 2292.5 N/s was significantly greater than iVib (7156.4 ± 2170.0 N/s. However, the other experimental trials for RFD demonstrated no significant differences (p>0.05. There were also no significant differences for rRFD, GRF or rGRF between protocols. Conclusion: These results demonstrate that a dynamic warm-up without WBV elicits greater RFD than an isometric warm-up with WBV prior to a maximal isometric exercise. Further research needs to be investigated utilizing dynamic and isometric warm-ups in conjunction with WBV and power output. Keywords: males, recreationally trained, power

  14. Thermoelastic Properties of Layered Perovskites: A Non-empirical Density Functional Theory Approach

    Science.gov (United States)

    Chizmeshya, A. V. G.; Petuskey, W. T.

    1997-03-01

    We present the results of an exploratory theoretical study of the structural and thermoelastic properties of layered perovskites KCa_2Nb_3O_10 and RbCa_3Nb_3O_10. The pressure and temperature dependence of the phonon spectra, elastic moduli, structural parameters and cohesive energies are obtained from a direct minimization of the Gibbs free energy of the crystal with respect to structural and electronic degrees of freedom. A variationally induced breathing (VIB) scheme is used to deform the constituent Kohn-Sham pseudo-ion charge densities . Preliminary results for the foliation energies, equations of state for both compounds are presented.

  15. Density functional theory studies of screw dislocation core structures in bcc metals

    DEFF Research Database (Denmark)

    Frederiksen, Søren Lund; Jacobsen, Karsten Wedel

    2003-01-01

    The core structures of (I 11) screw dislocations in bee metals are studied using density functional theory in the local-density approximation. For Mo and Fe, direct calculations of the core structures show the cores to be symmetric with respect to 180degrees rotations around an axis perpendicular...... to the dislocation line. The magnetic moment in the Fe core is shown to be reduced relative to the bulk value. Calculations of gamma surfaces and the elastic constants B, C' and c(44) are reported for Fe and all group VB and VIB metals. Using a criterion suggested by Vitek and Duesbery the calculations point...

  16. Research of Linear Translation Devices with Stepper Motor

    Directory of Open Access Journals (Sweden)

    Dmitrij Komissarov

    2016-04-01

    Full Text Available In order to ensure accuracy of motorized linear translation stages theoretical and experimental investigations were performed, that allow to establish moving platform vibration level depending of operating modes (different velocities and used lubricant in the system. Lubricants had different viscosity, which has effect to the system moving smoothness, sound level and vibration level of the stage. Such work gives possibility to done conclusions: with what lubricant or with what viscosity of the lubricant motorized linear translation stage works smoother, with less noise and vib-ration level, and also show best movement characteristics.

  17. The Shock and Vibration Digest. Volume 12, Number 4.

    Science.gov (United States)

    1980-04-01

    problem in- The Use of Elastomer in Roling Contact Surfaces volves aerodynamic and structureborne sources that radiate J.G. Bollinger , R.H. Chan, and J.F...Importance of Railway Noise in France M. Maurin Institut de Recherche ca:s Transports, Centre d’Evalu- 80-773 ation et de Recherche des Nuisances, Bron...Cedex Railway Noise and Vibration Annoyance in Resden- 69672, France , J. Sound Vib., 66 (3), pp 493-496 ial Armas (Oct 8, 1979) 3 tables J.M. Fields

  18. A model for sound propagation between two adsorbing microporous plates.

    Science.gov (United States)

    Nori, Massimiliano; Brandani, Stefano

    2014-05-01

    A model describing the sound propagation between two infinite adsorbing plates is proposed in order to investigate the extension to the audible sound range of the Frequency Response method applied to the measurement of diffusion in micropores. The model relates adsorption parameters (i.e., diffusivity and equilibrium constant) to an acoustic quantity (i.e., propagation constant). The equations describing sound propagation in the presence of adsorbing boundaries are obtained on the basis of the classical Kirchhoff theory [(1868). Ann. Phys. (Leipzig) 134, 177-193]. The solution is derived using the Low Reduced Frequency Approximation method [Tijdeman, (1975). J. Sound Vib. 39, 1-33].

  19. Demetallization of hydrocarbon containing feed streams

    International Nuclear Information System (INIS)

    Kukes, S.G.; Hawley, G.R.

    1986-01-01

    This patent describes how metals contained in a hydrocarbon containing feed stream are removed by contacting the hydrocarbon containing feed stream under suitable demetallization conditions with hydrogen and a catalyst composition comprising zirconium phosphate, cobalt phosphate and iron phosphate. The life and activity of the catalyst composition may be increased by introducing a decomposable metal compound selected from the group consisting of the metals of Group V-B, Group VI-B, Group VII-B and Group VIII of the Periodic Table into the hydrocarbon containing feed stream prior to contacting the hydrocarbon containing feed stream with the catalyst composition

  20. ESTIMATIVA DA VELOCIDADE DE INFILTRAÇÃO BÁSICA DO SOLO ESTIMATION OF THE SOIL BASIC INFILTRATION VELOCITY

    Directory of Open Access Journals (Sweden)

    LUÍS EDUARDO DE OLIVEIRA SALES

    1999-11-01

    Full Text Available Objetivando estimar a velocidade de infiltração básica (VIB, avaliou-se a associação desta com outras propriedades físicas das camadas superficial e subsuperficial de um Latossolo Roxo e um Podzólico Vermelho-Amarelo, ambos ocorrentes no campus da Universidade Federal de Lavras. Para tanto, delineou-se um plano amostral consistindo de uma rede cujas malhas apresentaram espaçamentos variáveis. Nos pontos de interseção das malhas determinou-se a VIB e, posteriormente, coletaram-se amostras com estrutura deformada e indeformada nas camadas de 0-20 e 60-80 cm. Com essas amostras determinou-se a textura, densidade do solo e de partículas, porosidade total, macro e microporosidade e condutividade hidráulica do solo saturado. Após análises estatísticas de correlação e regressão, verificou-se que as propriedades físicas da camada de 0-20 cm do Latossolo Roxo e 60-80 cm do Podzólico Vermelho-Amarelo associaram-se melhor com a VIB. Tanto a condutividade hidráulica do solo saturado quanto a densidade do solo se mostraram adequadas para estimar a VIB desses solos.With the objective of estimating the soil basic infiltration velocity (BIV, a study was conducted to evaluate the degree of association between BIV and other physical properties of the superficial and subsuperficial layers of a Dusky-Red Latosol (Oxisol and of a Red-Yellow Podzolic soil (Ultisol, both located at the campus of the Universidade Federal de Lavras, Minas Gerais State, Brazil. The sampling was performed with systematic spacing and the points constituted a grid, with variable spacing. At each sampling point, the value of the basic infiltration velocity was determined and thereafter undisturbed and disturbed samples at 0-20 and 60-80 cm of depth were collected. With these samples, the particle-size distribution, bulk density, particle density, total volume of pores, macroporosity, microporosity and hydraulic conductivity of saturated soil were determined. Statistical

  1. MAPPI-DAT: data management and analysis for protein-protein interaction data from the high-throughput MAPPIT cell microarray platform.

    Science.gov (United States)

    Gupta, Surya; De Puysseleyr, Veronic; Van der Heyden, José; Maddelein, Davy; Lemmens, Irma; Lievens, Sam; Degroeve, Sven; Tavernier, Jan; Martens, Lennart

    2017-05-01

    Protein-protein interaction (PPI) studies have dramatically expanded our knowledge about cellular behaviour and development in different conditions. A multitude of high-throughput PPI techniques have been developed to achieve proteome-scale coverage for PPI studies, including the microarray based Mammalian Protein-Protein Interaction Trap (MAPPIT) system. Because such high-throughput techniques typically report thousands of interactions, managing and analysing the large amounts of acquired data is a challenge. We have therefore built the MAPPIT cell microArray Protein Protein Interaction-Data management & Analysis Tool (MAPPI-DAT) as an automated data management and analysis tool for MAPPIT cell microarray experiments. MAPPI-DAT stores the experimental data and metadata in a systematic and structured way, automates data analysis and interpretation, and enables the meta-analysis of MAPPIT cell microarray data across all stored experiments. MAPPI-DAT is developed in Python, using R for data analysis and MySQL as data management system. MAPPI-DAT is cross-platform and can be ran on Microsoft Windows, Linux and OS X/macOS. The source code and a Microsoft Windows executable are freely available under the permissive Apache2 open source license at https://github.com/compomics/MAPPI-DAT. jan.tavernier@vib-ugent.be or lennart.martens@vib-ugent.be. Supplementary data are available at Bioinformatics online. © The Author 2017. Published by Oxford University Press.

  2. Electronic structure and shearing in nanolaminated ternary carbides

    Science.gov (United States)

    Music, Denis; Sun, Zhimei; Voevodin, Andrey A.; Schneider, Jochen M.

    2006-07-01

    We have studied shearing in M 2AlC phases (M=Sc,Y,La,Ti,Zr,Hf,V,Nb,Ta,Cr,Mo,W) using ab initio calculations. We propose that these phases can be classified into two groups based on the valence electron concentration induced changes in C 44. One group comprises M=V B and VIB, where the C 44 values are approximately 170 GPa and independent of the corresponding MC. The other group includes M=IIIB and IVB, where the C 44 shows a linear dependency with the corresponding MC. This may be understood based on the electronic structure: shear resistant bands are filled in M 2AlC phases with M=V B and VIB, while they are not completely filled when M=IIIB and IVB. This notion is also consistent with our stress-strain analysis. These valence electron concentration induced changes in shear behaviour were compared to previously published valence electron concentration induced changes in compression behaviour [Z. Sun, D. Music, R. Ahuja, S. Li, J.M. Schneider, Phys. Rev. B 70 (2004) 092102]. These classification proposals exhibit identical critical valence electron concentration values for the group boundary. However, the physical mechanisms are not identical: the classification proposal for the bulk modulus is based on MC-A coupling, while shearing is based on MC-MC coupling.

  3. Thin film photoelectric converter; Hakumaku koden henkan soshi

    Energy Technology Data Exchange (ETDEWEB)

    Mori, K.; Takamizawa, M.; Sakaguci, A.

    1996-07-30

    Ib-IIIb-VIb group compound semiconductor represented by CuInSe2 having chalcopyrite crystalline structure is promising as a material for making thin film and high efficient solar cells. The problem with the solar cell elements fabricated using this material, however, is variance in the characteristics of photoelectric conversion. This invention relates to improvement of the ununiformity of the photoelectric conversion property by the use of a glass substrate, which contains each of the alkali and alkali earth elements such as Na, K, Ba, Sr, and Ca in the ratio of less than 1% of the substrate weight, and a thin film photoelectric converter structured containing a photoelectric conversion layer whose main components are the elements selected out of each Ib group, IIIb group, and VIb group. In addition, the uniformity of the photoelectric conversion layer can be further improved if one or more than two kinds of elements with larger than 1.70 angstrom atomic radius are contained in the photoelectric conversion layer in the ratio from 5ppm to 5 wt%. 1 fig.

  4. Raman Spectra of ZrS2 and ZrSe2 from Bulk to Atomically Thin Layers

    Directory of Open Access Journals (Sweden)

    Samuel Mañas-Valero

    2016-09-01

    Full Text Available In the race towards two-dimensional electronic and optoelectronic devices, semiconducting transition metal dichalcogenides (TMDCs from group VIB have been intensively studied in recent years due to the indirect to direct band-gap transition from bulk to the monolayer. However, new materials still need to be explored. For example, semiconducting TMDCs from group IVB have been predicted to have larger mobilities than their counterparts from group VIB in the monolayer limit. In this work we report the mechanical exfoliation of ZrX2 (X = S, Se from bulk down to the monolayer and we study the dimensionality dependence of the Raman spectra in ambient conditions. We observe Raman signal from bulk to few layers and no shift in the peak positions is found when decreasing the dimensionality. While a Raman signal can be observed from bulk to a bilayer for ZrS2, we could only detect signal down to five layers for flakes of ZrSe2. These results show the possibility of obtaining atomically thin layers of ZrX2 by mechanical exfoliation and represent one of the first steps towards the investigation of the properties of these materials, still unexplored in the two-dimensional limit.

  5. Camelid Single-Domain Antibodies: Historical Perspective and Future Outlook.

    Science.gov (United States)

    Arbabi-Ghahroudi, Mehdi

    2017-01-01

    Tremendous effort has been expended over the past two and a half decades to understand many aspects of camelid heavy chain antibodies, from their biology, evolution, and immunogenetics to their potential applications in various fields of research and medicine. In this article, I present a historical perspective on the development of camelid single-domain antibodies (sdAbs or V H Hs, also widely known as nanobodies) since their discovery and discuss the advantages and disadvantages of these unique molecules in various areas of research, industry, and medicine. Commercialization of camelid sdAbs exploded in 2001 with a flurry of patents issued to the Vrije Universiteit Brussel (VUB) and later taken on by the Vlaams Interuniversitair Instituut voor Biotechnologie (VIB) and, after 2002, the VIB-founded spin-off company, Ablynx. While entrepreneurial spirit has certainly catalyzed the exploration of nanobodies as marketable products, IP restrictions may be partially responsible for the relatively long time span between the discovery of these biomolecules and their entry into the pharmaceutical market. It is now anticipated that the first V H H-based antibody drug, Caplacizumab, a bivalent anti-vWF antibody for treating rare blood clotting disorders, may be approved and commercialized in 2018 or shortly thereafter. This elusive first approval, along with the expiry of key patents, may substantially alter the scientific and biomedical landscape surrounding camelid sdAbs and pave the way for their emergence as mainstream biotherapeutics.

  6. Vibrational and magnetic contributions to the entropy change associated with the martensitic transformation of Ni-Fe-Ga ferromagnetic shape memory alloys

    Energy Technology Data Exchange (ETDEWEB)

    Recarte, V; Perez-Landazabal, J I; Gomez-Polo, C; Sanchez-Alarcos, V [Departamento de Fisica, Universidad Publica de Navarra, Campus de Arrosadia, 31006 Pamplona (Spain); Cesari, E; Pons, J [Departament de Fisica, Universitat de les Illes Balears, Ctra. de Valldemossa, km 7.5, E-07122 Palma de Mallorca (Spain)

    2010-10-20

    Ferromagnetic shape memory alloys undergo a martensitic transformation accompanied by a change in the magnetic and vibrational properties. However, these property changes are not independent. In this paper, the interplay between magnetic and vibrational properties in the martensitic transformation entropy change has been analyzed for Ni-Fe-Ga ferromagnetic shape memory alloys. The martensitic transformation entropy change has a magnetic and a vibrational contribution, {Delta}S{sup p{yields}m}={Delta}S{sub vib}{sup p{yields}m}+{Delta}S{sub mag}{sup p{yields}m}. Using a mean field approximation for the magnetic entropy, the full entropy {Delta}S{sup p{yields}m} has been decomposed and the magnetic contribution {Delta}S{sub mag}{sup p{yields}m} calculated. Upon removing the magnetic term, the vibrational entropy {Delta}S{sub vib}{sup p{yields}m} does not change substantially in the composition range where T{sub M} is below T{sub C}. This latter contribution to the martensitic transformation entropy change has been analyzed using a Debye distribution for the density of states and a proportion of Einstein modes that account for the anomalous phonon mode of the austenite.

  7. SNF verification requirements imposed through 10 CFR Part 961: Interrelationship with MC ampersand A requirements for the OCRWM safeguards system

    International Nuclear Information System (INIS)

    Slater, N.; Vance, S.

    1994-01-01

    Article VI.B.2 of the Standard Contract for Disposal of Spent Nuclear Fuel and/or High-Level Radioactive Waste (10 CFR Part 961, Standard Contract) provides that spent nuclear fuel shall be subject to verification prior to acceptance by the Department of Energy. As part of the overall process for scheduling deliveries of spent nuclear fuel, the Standard Contract requires contract holders to submit detailed descriptions of the spent nuclear fuel they intend to deliver. Thus, the provision for verification in the Standard contract allows the Department the opportunity to ensure that the spent nuclear fuel intended for deliver is consistent with the description provided, and that the material is properly loaded, packaged, marked, and labeled. The Department is currently evaluating the verification requirements for spent nuclear fuel that it will establish pursuant to Article VI.B.2 of the Standard Contract. The Department recognizes that there may be significant overlap between these verification requirements and the requirements established for material control and accountability (MC ampersand A). Therefore, the Department may recommend modifications to the process established in the Standard Contract to ensure that the verification and MC ampersand A functions and activities are fully integrated

  8. Selection of the N-acylhomoserine lactone-degrading bacterium Alteromonas stellipolaris PQQ-42 and of its potential for biocontrol in aquaculture

    Directory of Open Access Journals (Sweden)

    Marta eTorres

    2016-05-01

    Full Text Available The production of virulence factors by many pathogenic microorganisms depends on the intercellular communication system called quorum sensing (QS, which involves the production and release of signal molecules known as autoinducers. Based on this, new-therapeutic strategies have emerged for the treatment of a variety of infections, such as the enzymatic degradation of signalling molecules, known as quorum quenching (QQ. In this study, we present the screening of QQ activity amongst 450 strains isolated from a bivalve hatchery in Granada (Spain, and the selection of the strain PQQ-42, which degrades a wide range of N-acylhomoserine lactones (AHLs. The selected strain, identified as Alteromonas stellipolaris, degraded the accumulation of AHLs and reduced the production of protease and chitinase and swimming motility of a Vibrio species in co-cultivation experiments in vitro. In the bio-control experiment, strain PQQ-42 significantly reduced the pathogenicity of V. mediterranei VibC-Oc-097 upon the coral Oculina patagonica showing a lower degree of tissue damage (29.25±14.63 % in its presence, compared to when the coral was infected with V. mediterranei VibC-Oc-097 alone (77.53±13.22 %. Our results suggest that this AHL-degrading bacterium may have biotechnological applications in aquaculture.

  9. Experiment of exploration using the active-faults exploration system; Katsudanso tansa system wo mochiita chika tansa jikken

    Energy Technology Data Exchange (ETDEWEB)

    Mikada, H.; Sato, H.; Iwasaki, T.; Hirata, N. [The University of Tokyo, Tokyo (Japan). Earthquake Research Institute; Ikeda, Y. [The University of Tokyo, Tokyo (Japan). Faculty of Science; Ikawa, T.; Kawabe, Y.; Aoki, Y. [JAPEX Geoscience Institute, Tokyo (Japan)

    1996-10-01

    A system for exploration of active-faults by seismic reflection profiling method was introduced at Earthquake Research Institute, University of Tokyo. A test-run was conducted to check the performance of this system at Ranzan, Saitama Prefecture. This paper describes the confirmed performance of mini-VIB as a wide band frequency seismic source, the quality of data obtained using a digital data acquisition system, and problems for data processing of fault exploration in the future. For the test-run at Ranzan, two-dimensional exploration was conducted by the quasi-three-dimensional data acquisition method using three geophones of 8 Hz, 28 Hz, and 40 Hz, simply arranged in parallel on the measurement line. Using an active seismic vibrator, mini-VIB, data acquisition of faults in the wide band frequency was achieved, which would result in the highly accurate imaging. Operation of data acquisition and processing systems is easy, and the system can be also used as a kind of black box. The existing methods are to be used sufficiently as a tool for imaging of faults. Further research for accumulating experience may become necessary toward the extension of the system expected in the future. 5 refs., 6 figs.

  10. Camelid Single-Domain Antibodies: Historical Perspective and Future Outlook

    Directory of Open Access Journals (Sweden)

    Mehdi Arbabi-Ghahroudi

    2017-11-01

    Full Text Available Tremendous effort has been expended over the past two and a half decades to understand many aspects of camelid heavy chain antibodies, from their biology, evolution, and immunogenetics to their potential applications in various fields of research and medicine. In this article, I present a historical perspective on the development of camelid single-domain antibodies (sdAbs or VHHs, also widely known as nanobodies since their discovery and discuss the advantages and disadvantages of these unique molecules in various areas of research, industry, and medicine. Commercialization of camelid sdAbs exploded in 2001 with a flurry of patents issued to the Vrije Universiteit Brussel (VUB and later taken on by the Vlaams Interuniversitair Instituut voor Biotechnologie (VIB and, after 2002, the VIB-founded spin-off company, Ablynx. While entrepreneurial spirit has certainly catalyzed the exploration of nanobodies as marketable products, IP restrictions may be partially responsible for the relatively long time span between the discovery of these biomolecules and their entry into the pharmaceutical market. It is now anticipated that the first VHH-based antibody drug, Caplacizumab, a bivalent anti-vWF antibody for treating rare blood clotting disorders, may be approved and commercialized in 2018 or shortly thereafter. This elusive first approval, along with the expiry of key patents, may substantially alter the scientific and biomedical landscape surrounding camelid sdAbs and pave the way for their emergence as mainstream biotherapeutics.

  11. Tritium recovery from tritiated water with a two-stage palladium membrane reactor

    Energy Technology Data Exchange (ETDEWEB)

    Birdsell, S.A.; Willms, R.S.

    1997-04-01

    A process to recover tritium from tritiated water has been successfully demonstrated at TSTA. The 2-stage palladium membrane reactor (PMR) is capable of recovering tritium from water without generating additional waste. This device can be used to recover tritium from the substantial amount of tritiated water that is expected to be generated in the International Thermonuclear Experimental Reactor both from torus exhaust and auxiliary operations. A large quantity of tritiated waste water exists world wide because the predominant method of cleaning up tritiated streams is to oxidize tritium to tritiated water. The latter can be collected with high efficiency for subsequent disposal. The PMR is a combined catalytic reactor/permeator. Cold (non-tritium) water processing experiments were run in preparation for the tritiated water processing tests. Tritium was recovered from a container of molecular sieve loaded with 2,050 g (2,550 std. L) of water and 4.5 g of tritium. During this experiment, 27% (694 std. L) of the water was processed resulting in recovery of 1.2 g of tritium. The maximum water processing rate for the PMR system used was determined to be 0.5 slpm. This correlates well with the maximum processing rate determined from the smaller PMR system on the cold test bench and has resulted in valuable scale-up and design information.

  12. Tritium proof-of-principle pellet injector results

    International Nuclear Information System (INIS)

    Fisher, P.W.; Fehling, D.T.; Gouge, M.J.; Milora, S.L.

    1989-01-01

    The tritium proof-of-principle (TPOP) experiment was built by Oak Ridge National Laboratory (ORNL) to demonstrate the feasibility of forming solid tritium pellets and accelerating them to high velocities for fueling future fusion reactors. TPOP used a pneumatic pipe-gun with a 4-mm-i.d. by 1-m-long barrel. Nearly 1500 pellets were fired by the gun during the course of the experiment; about a third of these were tritium or mixtures of deuterium and tritium. The system also contained a cryogenic 3 He separator that reduced the 3 He level to <0.005%. Pure tritium pellets were accelerated to 1400 m/s. Experiments evaluated the effect of cryostat temperature and fill pressure on pellet size, the production of pellets from mixtures of tritium and deuterium, and the effect of aging on pellet integrity. The tritium phase of these experiments was performed at the Tritium Systems Test Assembly (TSTA) at Los Alamos National Laboratory. About 100 kCi of tritium was processed through the apparatus without incident. 8 refs., 7 figs

  13. Export Control Requirements for Tritium Processing Design and R&D

    Energy Technology Data Exchange (ETDEWEB)

    Hollis, William Kirk [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Maynard, Sarah-Jane Wadsworth [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-04-05

    This document will address requirements of export control associated with tritium plant design and processes. Los Alamos National Laboratory has been working in the area of tritium plant system design and research and development (R&D) since the early 1970’s at the Tritium Systems Test Assembly (TSTA). This work has continued to the current date with projects associated with the ITER project and other Office of Science Fusion Energy Science (OS-FES) funded programs. ITER is currently the highest funding area for the DOE OS-FES. Although export control issues have been integrated into these projects in the past a general guidance document has not been available for reference in this area. To address concerns with currently funded tritium plant programs and assist future projects for FES, this document will identify the key reference documents and specific sections within related to tritium research. Guidance as to the application of these sections will be discussed with specific detail to publications and work with foreign nationals.

  14. Performance of a palladium membrane reactor using a Ni catalyst for fusion fuel impurities processing

    International Nuclear Information System (INIS)

    Willm, R.S.; Okuno, K.

    1994-01-01

    The palladium membrane reactor (PMR) provides a means to recover hydrogen isotopes from impurities expected to be present in fusion reactor exhaust. This recovery is based on reactions such as water gas shift and steam reforming for which conversion is equilibrium limited. By including a selectively permeable membrane such as Pd/Ag in the catalyst bed, hydrogen isotopes can be removed from the reacting environment, thus promoting the reaction to complete conversion. Such a device has been built and operated at the Tritium Systems Test Assembly (TSTA) at Los Alamos National Laboratory (LANL). For the reactions listed above, earlier study with this unit has shown that hydrogen single-pass recoveries approaching 100% can be achieved. It was also determined that a nickel catalyst is a feasible choice for use with a PMR appropriate for fusion fuel impurities processing. The purpose of this study is to systematically assess the performance of the PMR using a nickel catalyst. Reactions which will be studied include the water gas shift reaction, steam reforming and methane cracking. Extended operation will be performed to detect performance degradation if it exists. The use of methane in these tests may lead to the formation of coke on the catalyst. Methods of removing the coke such as treatment with carbon dioxide or diluted oxygen will be examined

  15. Considerations for tritium protection at a fusion reactor

    International Nuclear Information System (INIS)

    Easterly, C.E.

    1982-01-01

    The view on the radiological hazard associated with future fusion power stations as presented in this discussion is rarely supported by reasonably certain or reliably accurate prediction. This fact should not be taken as indicating a major programmatic deficiency. In fact, it is expected that large uncertainty would be present in health effect at the current level of technological development. The details of tritium exposure will be clarified, waiting for the operation of the Tritium System Test Assembly. Once the data base for the TSTA is established, future fusion design can be made based on economic cost/radiation exposure risk benefit. The actual execution of this cost/benefit analysis is complex because three populations are of interest: occupational work force, local population and global population. The knowledge of tritium management must be increased if D-T fusion reactors are to become compatible with the needs of utility companies. In order to exploit the differing hazard between HT and HTO, it is necessary to know much more about the mechanism of uncatalyzed conversion over a wide range of concentration and about the change caused by the variety of potential catalytic sequence in potential tritium leak. (Kako, I.)

  16. Export Control Requirements for Tritium Processing Design and R&D

    Energy Technology Data Exchange (ETDEWEB)

    Hollis, William Kirk [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Maynard, Sarah-Jane Wadsworth [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-10-30

    This document will address requirements of export control associated with tritium plant design and processes. Los Alamos National Laboratory has been working in the area of tritium plant system design and research and development (R&D) since the early 1970’s at the Tritium Systems Test Assembly (TSTA). This work has continued to the current date with projects associated with the ITER project and other Office of Science Fusion Energy Science (OS-FES) funded programs. ITER is currently the highest funding area for the DOE OS-FES. Although export control issues have been integrated into these projects in the past a general guidance document has not been available for reference in this area. To address concerns with currently funded tritium plant programs and assist future projects for FES, this document will identify the key reference documents and specific sections within related to tritium research. Guidance as to the application of these sections will be discussed with specific detail to publications and work with foreign nationals.

  17. Effect of tendon vibration during wide-pulse neuromuscular electrical stimulation (NMES) on the decline and recovery of muscle force.

    Science.gov (United States)

    Bochkezanian, Vanesa; Newton, Robert U; Trajano, Gabriel S; Vieira, Amilton; Pulverenti, Timothy S; Blazevich, Anthony J

    2017-05-02

    Neuromuscular electrical stimulation (NMES) is commonly used to activate skeletal muscles and reverse muscle atrophy in clinical populations. Clinical recommendations for NMES suggest the use of short pulse widths (100-200 μs) and low-to-moderate pulse frequencies (30-50 Hz). However, this type of NMES causes rapid muscle fatigue due to the (non-physiological) high stimulation intensities and non-orderly recruitment of motor units. The use of both wide pulse widths (1000 μs) and tendon vibration might optimize motor unit activation through spinal reflex pathways and thus delay the onset of muscle fatigue, increasing muscle force and mass. Thus, the objective of this study was to examine the acute effects of patellar tendon vibration superimposed onto wide-pulse width (1000 μs) knee extensor electrical stimulation (NMES, 30 Hz) on peak muscle force, total impulse before "muscle fatigue", and the post-exercise recovery of muscle function. Tendon vibration (Vib), NMES (STIM) or NMES superimposed onto vibration (STIM + Vib) were applied in separate sessions to 16 healthy adults. Total torque-time integral (TTI), maximal voluntary contraction torque (MVIC) and indirect measures of muscle damage were tested before, immediately after, 1 h and 48 h after each stimulus. TTI increased (145.0 ± 127.7%) in STIM only for "positive responders" to the tendon vibration (8/16 subjects), but decreased in "negative responders" (-43.5 ± 25.7%). MVIC (-8.7%) and rectus femoris electromyography (RF EMG) (-16.7%) decreased after STIM (group effect) for at least 1 h, but not after STIM + Vib. No changes were detected in indirect markers of muscle damage in any condition. Tendon vibration superimposed onto wide-pulse width NMES increased TTI only in 8 of 16 subjects, but reduced voluntary force loss (fatigue) ubiquitously. Negative responders to tendon vibration may derive greater benefit from wide-pulse width NMES alone.

  18. High-temperature corrosion-resistant iron-aluminide (FeAl) alloys exhibiting improved weldability

    Science.gov (United States)

    Maziasz, Philip J.; Goodwin, Gene M.; Liu, Chain T.

    1996-01-01

    This invention relates to improved corrosion-resistant iron-aluminide intermetallic alloys. The alloys of this invention comprise, in atomic percent, from about 30% to about 40% aluminum alloyed with from about 0.1% to about 0.5% carbon, no more than about 0.04% boron such that the atomic weight ratio of boron to carbon in the alloy is in the range of from about 0.01:1 to about 0.08:1, from about 0.01 to about 3.5% of one or more transition metals selected from Group IVB, VB, and VIB elements and the balance iron wherein the alloy exhibits improved resistance to hot cracking during welding.

  19. Chromatography of metal ions with a triazine chelating resin

    Energy Technology Data Exchange (ETDEWEB)

    Wang, W.N.

    1979-05-01

    The synthesis, characterization, and some analytical applications of a new triazine resin are described. Separation of group IB, IIB, VIB, and VIIB metal ions from group VIII metal ions is achieved by this PDT-4 resin. Calcium(II) and magnesium(II) are taken up at pH = 6, 0.1 M acetate and are eluted at pH = 6, 0.1 M sodium nitrate. Copper(II) is retained at pH = 6, 0.1 M acetate and pH = 1 hydrochloric acid and is eluted subsequently by 5 M perchloric acid. Molybdenum(VI) is sorbed selectively from 0.1 N sulfuric acid or hydrochloric acid and is eluted in a tight band by 0.1 N sodium hydroxide. Numerous rapid column chromatographic separations are reported using this new resin, including analysis of NBS standard samples.

  20. Role of the lattice in the gamma-->alpha phase transition of Ce: a high-pressure neutron and x-ray diffraction study.

    Science.gov (United States)

    Jeong, I-K; Darling, T W; Graf, M J; Proffen, Th; Heffner, R H; Lee, Yongjae; Vogt, T; Jorgensen, J D

    2004-03-12

    The temperature and pressure dependence of the thermal displacements and lattice parameters were obtained across the gamma-->alpha phase transition of Ce using high-pressure, high-resolution neutron and synchrotron x-ray powder diffraction. The estimated vibrational entropy change per atom in the gamma-->alpha phase transition, DeltaS(gamma-alpha)(vib) approximately (0.75+/-0.15)k(B), is about half of the total entropy change. The bulk modulus follows a power-law pressure dependence that is well described using the framework of electron-phonon coupling. These results clearly demonstrate the importance of lattice vibrations, in addition to the spin and charge degrees of freedom, for a complete description of the gamma-->alpha phase transition in elemental Ce.

  1. Prediction of two-dimensional diluted magnetic semiconductors: Doped monolayer MoS2 systems

    KAUST Repository

    Cheng, Yingchun

    2013-03-05

    Using first-principles calculations, we propose a two-dimensional diluted magnetic semiconductor: monolayer MoS2 doped by transition metals. Doping of transition metal atoms from the IIIB to VIB groups results in nonmagnetic states, since the number of valence electrons is smaller or equal to that of Mo. Doping of atoms from the VIIB to IIB groups becomes energetically less and less favorable. Magnetism is observed for Mn, Fe, Co, Zn, Cd, and Hg doping, while for the other dopants from these groups it is suppressed by Jahn-Teller distortions. Analysis of the binding energies and magnetic properties indicates that (Mo,X)S2 (X=Mn, Fe, Co, and Zn) are promising systems to explore two-dimensional diluted magnetic semiconductors.

  2. NanoPack: visualizing and processing long read sequencing data.

    Science.gov (United States)

    De Coster, Wouter; D'Hert, Svenn; Schultz, Darrin T; Cruts, Marc; Van Broeckhoven, Christine

    2018-03-14

    Here we describe NanoPack, a set of tools developed for visualization and processing of long read sequencing data from Oxford Nanopore Technologies and Pacific Biosciences. The NanoPack tools are written in Python3 and released under the GNU GPL3.0 License. The source code can be found at https://github.com/wdecoster/nanopack, together with links to separate scripts and their documentation. The scripts are compatible with Linux, Mac OS and the MS Windows 10 subsystem for Linux and are available as a graphical user interface, a web service at http://nanoplot.bioinf.be and command line tools. wouter.decoster@molgen.vib-ua.be. Supplementary tables and figures are available at Bioinformatics online.

  3. Vibrational spectral investigation on xanthine and its derivatives—theophylline, caffeine and theobromine

    Science.gov (United States)

    Gunasekaran, S.; Sankari, G.; Ponnusamy, S.

    2005-01-01

    A normal coordinate analysis has been carried out on four compounds having a similar ring structure with different side chain substitutions, which are xanthine, caffeine, theophylline, and theobromine. Xanthine is chemically known as 2,6-dihydroxy purine. Caffeine, theophylline and theobromine are methylated xanthines. Considering the methyl groups as point mass, the number of normal modes of vibrations can be distributed as Γ vib=27 A'+12 A″ based on C s point group symmetry associated with the structures. In the present work 15 A' and 12 A″ normal modes are considered. A new set of orthonormal symmetry co-ordinates have been constructed. Wilson's F- G matrix method has been adopted for the normal coordinate analysis. A satisfactory vibrational band assignment has been made by employing the FTIR and FT Raman spectra of the compounds. The potential energy distribution is calculated with the arrived values of the force constants and hence the agreement of the frequency assignment has been checked.

  4. Interview with the Guest Editor - Jenny Russinova.

    Science.gov (United States)

    2018-01-29

    Jenny Russinova graduated in biotechnology from the University of Sofia, Bulgaria, and subsequently obtained her PhD at De Montfort University, Leicester, UK, where she worked on gene expression in plant embryogenesis. Jenny then moved to the Netherlands to do her post-doctoral studies at Wageningen University, Wageningen, in the laboratory of Sacco de Vries. There, she worked on cellular regulation, mechanisms and localization of plant receptor-like kinases. In 2006, she started her own research group at the Vlaams Instituut voor Biotechnologie (VIB) at Ghent University, Belgium, focusing on brassinosteroid signaling regulation in plants. Jenny is the Guest Editor for the 2018 plant cell biology Special Issue in Journal of Cell Science. © 2018. Published by The Company of Biologists Ltd.

  5. A Better Way to Excise Inhibitory Molecules (CSPGs) from a Spinal Cord Injury Scar to Promote Regeneration

    Science.gov (United States)

    2011-10-01

    C6 )  vertebrae  were  performed.  A  transverse  incision  was  made...in  the  dura  with  the  tip   of  a  sterile  30-­‐G  needle  between  the   C6  and  C7  dorsal  root  entry...Sticker Test Results Injury Type R e a c ti o n T im e ( s ) Sh am Vib raK nif e Sc iss or 0 10 20 30 40 n=14 n=21 n=27 Means 12.00 17.71

  6. Superconductivity and the Periodic Table

    International Nuclear Information System (INIS)

    Chapnik, I.M.

    1985-01-01

    In view of the inability of the present theory of superconductivity to make reliable predictions for the magnitude of Tsub(c) it seems useful to search for empirical relationships between the composition of the compound and the Tsub(c) value. Table I gives a list of the available Tsub(c) data for transition metals (TM) having from 3 to 9 outer electrons and Tsub(c) data for non-transition elements (NTE) of groups IIB, IIIB and IVB, including data for amorphous (Am) structures and structures (marked by triangles) obtained at high pressures. The analogous metals have therefore the same structure. In Tables II to IV the Tsub(c) data are presented for analogous compounds of NTE from IB - VIB group. Conclusions are presented. (author)

  7. The evolution of pigeon paramyxovirus type 1 (PPMV-1) in Great Britain: a molecular epidemiological study.

    Science.gov (United States)

    Aldous, E W; Fuller, C M; Ridgeon, J H; Irvine, R M; Alexander, D J; Brown, I H

    2014-04-01

    Newcastle disease (ND), caused by virulent strains of avian paramyxovirus type 1 (APMV-1), is considered throughout the world as one of the most important animal diseases. For over three decades now, there has been a continuing panzootic caused by a variant virulent APMV-1 strain, so-called pigeon paramyxovirus type 1 (PPMV-1), primarily in racing pigeons, which has also spread to wild birds and poultry. PPMV-1 isolations have been made in Great Britain every year since 1983. In this study, we have completed a comparative phylogenetic analysis based on a 374 nucleotide section of the fusion protein gene of 63 isolates of PPMV-1 that were isolated over a 26-year period; 43 of these were sequenced for this study. Phylogenetic analysis of these sequences revealed that all were closely related and placed in the genetic sublineage 4b (VIb), subdivision 4biif. © 2012 Crown copyright.

  8. Short duration small sided football and to a lesser extent whole body vibration exercise induce acute changes in markers of bone turnover

    DEFF Research Database (Denmark)

    Bowtell, Joanna L.; Jackman, Sarah R; Scott, Suzanne

    2016-01-01

    We aimed to study whether short-duration vibration exercise or football sessions of two different durations acutely changed plasma markers of bone turnover and muscle strain. Inactive premenopausal women (n = 56) were randomized to complete a single bout of short (FG15) or long duration (FG60.......6 ± 0.2 to 3.4 ± 1.2 mM) and FG60 (0.6 ± 0.2 to 3.3 ± 2.0 mM), but not for VIB (0.6 ± 0.2 to 0.8 ± 0.4 mM) (P minor elevation in osteocalcin...

  9. The genetic basis of amyotrophic lateral sclerosis: recent breakthroughs

    Directory of Open Access Journals (Sweden)

    Eykens C

    2015-10-01

    Full Text Available Caroline Eykens,1,2 Wim Robberecht1–31Research Group Experimental Neurology, Department of Neurosciences, KU Leuven – University of Leuven, Leuven, Belgium; 2Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium; 3Department of Neurology, University Hospitals Leuven, Leuven, BelgiumAbstract: Deciphering the genetic architecture of amyotrophic lateral sclerosis (ALS, an adult-onset neurodegenerative disorder of the motor neuron system, is important to understand the etiology of this fatal disease as well as to develop customized ALS therapies based on the patient's genetic fingerprint. In this review, we discuss the genetic basis of ALS, and attempt to link the causal genes to three highly interrelated pathogenic mechanisms: dysproteostasis, RNA dysregulation, and axon dysfunction. In addition, we address the clinical and biological implications of these genetic findings. Furthermore, we explore to what extent genetic knowledge can be converted into targeted and personalized treatments.Keywords: amyotrophic lateral sclerosis, frontotemporal dementia, genetics, disease modifiers, personalized medicine

  10. Peptide nucleic acid fluorescence in-situ hybridization for identification of Vibrio spp. in aquatic products and environments.

    Science.gov (United States)

    Zhang, Xiaofeng; Li, Ke; Wu, Shan; Shuai, Jiangbing; Fang, Weihuan

    2015-08-03

    A peptide nucleic acid fluorescence in situ hybridization (PNA-FISH) method was developed for specific detection of the Vibrio genus. In silico analysis by BLAST and ProbeCheck showed that the designed PNA probe targeting the 16S rRNAs was suitable for specific identification of Vibrio. Specificity and sensitivity of the probe Vib-16S-1 were experimentally verified by its reactivity against 18 strains of 9 Vibrio species and 14 non-Vibrio strains of 14 representative species. The PNA-FISH assay was able to identify 47 Vibrio positive samples from selectively enriched cultures of 510 samples of aquatic products and environments, comparable with the results obtained by biochemical identification and real-time PCR. We conclude that PNA-FISH can be an alternative method for rapid identification of Vibrio species in a broad spectrum of seafood or related samples. Copyright © 2015 Elsevier B.V. All rights reserved.

  11. Chromatography of metal ions with a triazine chelating resin

    International Nuclear Information System (INIS)

    Wang, W.N.

    1979-05-01

    The synthesis, characterization, and some analytical applications of a new triazine resin are described. Separation of group IB, IIB, VIB, and VIIB metal ions from group VIII metal ions is achieved by this PDT-4 resin. Calcium(II) and magnesium(II) are taken up at pH = 6, 0.1 M acetate and are eluted at pH = 6, 0.1 M sodium nitrate. Copper(II) is retained at pH = 6, 0.1 M acetate and pH = 1 hydrochloric acid and is eluted subsequently by 5 M perchloric acid. Molybdenum(VI) is sorbed selectively from 0.1 N sulfuric acid or hydrochloric acid and is eluted in a tight band by 0.1 N sodium hydroxide. Numerous rapid column chromatographic separations are reported using this new resin, including analysis of NBS standard samples

  12. The double pendulum: a numerical study

    Science.gov (United States)

    Calvão, A. M.; Penna, T. J. P.

    2015-07-01

    Analysis and characterization of dynamical systems is a common task in computational physics. It frequently demands new algorithms for finding solutions and new techniques for analysing the results. Here we review some of these algorithms and techniques in the study of the double pendulum, which, despite being a very simple mechanical system, can display complex behaviour. Even though it has been studied before (Yu and Bi 1998 J. Sound Vib. 217 691736; Stachowiak and Okada 2006 Chaos, Solitons & Fractals 29 417422; Rafat, Wheatland and Bedding 2009 Am. J. Phys. 77 216-23; Levien and Tan 1993 Am. J. Phys. 61 103844), here we present a deeper discussion of the several methods and algorithms that are used in typical studies of dynamical systems. In addition, we present new results obtained through techniques commonly used in the analysis of complex systems.

  13. Anion complexation and transport by isophthalamide and dipicolinamide derivatives: DNA plasmid transformation in E. coli.

    Science.gov (United States)

    Atkins, Jason L; Patel, Mohit B; Daschbach, Megan M; Meisel, Joseph W; Gokel, George W

    2012-08-22

    Tris-arenes based on either isophthalic acid or 2,6-dipicolinic acid have been known for more than a decade to bind anions. Recent studies have also demonstrated their ability to transport various ions through membranes. In this report, we demonstrate two important properties of these simple diamides. First, they transport plasmid DNA into Escherichia coli about 2-fold over controls, where the ampicillin resistance gene is expressed in the bacteria. These studies were done with plasmid DNA (~2.6 kilobase (kb)) in JM109 E. coli cells. Second, known methods do not typically transport large plasmids (>15 kb). We demonstrate here that transformation of large pVIB plasmids (i.e., >20 kb) were enhanced over water controls by ~10-fold. These results are in striking contrast to the normal decrease in transformation with increasing plasmid size.

  14. Alkali metal-refractory metal biphase electrode for AMTEC

    Science.gov (United States)

    Williams, Roger M. (Inventor); Bankston, Clyde P. (Inventor); Cole, Terry (Inventor); Khanna, Satish K. (Inventor); Jeffries-Nakamura, Barbara (Inventor); Wheeler, Bob L. (Inventor)

    1989-01-01

    An electrode having increased output with slower degradation is formed of a film applied to a beta-alumina solid electrolyte (BASE). The film comprises a refractory first metal M.sup.1 such as a platinum group metal, suitably platinum or rhodium, capable of forming a liquid or a strong surface adsorption phase with sodium at the operating temperature of an alkali metal thermoelectric converter (AMTEC) and a second refractory metal insoluble in sodium or the NaM.sup.1 liquid phase such as a Group IVB, VB or VIB metal, suitably tungsten, molybdenum, tantalum or niobium. The liquid phase or surface film provides fast transport through the electrode while the insoluble refractory metal provides a structural matrix for the electrode during operation. A trilayer structure that is stable and not subject to deadhesion comprises a first, thin layer of tungsten, an intermediate co-deposited layer of tungsten-platinum and a thin surface layer of platinum.

  15. Synthesis of o-carboranylmethyl ethers of steroids as potential target substrates for boron neutron capture therapy

    International Nuclear Information System (INIS)

    Schneiderova, L.; Gruener, B.; Strouf, O.; Kimlova, I.

    1992-01-01

    o-carboranylmethyl ethers of steroids were synthesized by insertion of steroidal 2-propynyloxy derivatives into 6,9-bis(acetonitrile)decarborane. This reaction provided compounds with an estrane and androstane skeleton, potentially useful in boron neutron capture therapy of hormone-sensitive forms of cancer: 17β-o-carboranylmethyl ether of estradiol IXb (yield 14%) and 3β- and 17β-carboranylmethyl ethers of androstenediol Vb and VIIb (yield 12% and 13%, respectively). Jones oxidation gave the carboranyl derivative of androsten-17-one VIb in 75% yield. As shown by a study of insertion of 3β-(2-propynyloxy)cholest-5-ene (IVa), the low yields of the insertion reaction cannot be increased by change in the reaction conditions. The relative binding affinity of compound IXb to the estrogen receptor from rat uterine and human breast tumor cytosol was 3.0 and 0.29%, respectively, of that of estradiol. (author) 2 figs., 2 tabs., 20 refs

  16. Code development incorporating environmental, safety, and economic aspects of fusion reactors (FY 92--94). Final report

    Energy Technology Data Exchange (ETDEWEB)

    Ho, S.K.; Fowler, T.K.; Holdren, J.P. [eds.

    1994-11-01

    This is the Final Report for a three-year (FY 92--94) study of the Environmental, Safety, and Economic (ESE) aspects of fusion energy systems, emphasizing development of computerized approaches suitable for incorporation as modules in fusion system design codes. First, as is reported in Section 2, the authors now have operating a simplified but complete environment and safety evaluation code, BESAFE. The first tests of BESAFE as a module of the SUPERCODE, a design optimization systems code at LLNL, are reported in Section 3. Secondly, as reported in Section 4, the authors have maintained a strong effort in developing fast calculational schemes for activation inventory evaluation. In addition to these major accomplishments, considerable progress has been made on research on specific topics as follows. A tritium modeling code TRIDYN was developed in collaboration with the TSTA group at LANL and the Fusion Nuclear Technology group at UCLA. A simplified algorithm has been derived to calculate the transient temperature profiles in the blanket during accidents. The scheme solves iteratively a system of non-linear ordinary differential equations describing about 10 regions of the blanket by preserving energy balance. The authors have studied the physics and engineering aspects of divertor modeling for safety applications. Several modifications in the automation and characterization of environmental and safety indices have been made. They have applied this work to the environmental and safety comparisons of stainless steel with alternative structural materials for fusion reactors. A methodology in decision analysis utilizing influence and decision diagrams has been developed to model fusion reactor design problems. Most of the work during this funding period has been reported in 26 publications including theses, journal publications, conference papers, and technical reports, as listed in Section 11.

  17. Bovine Host Genetic Variation Influences Rumen Microbial Methane Production with Best Selection Criterion for Low Methane Emitting and Efficiently Feed Converting Hosts Based on Metagenomic Gene Abundance.

    Directory of Open Access Journals (Sweden)

    Rainer Roehe

    2016-02-01

    Full Text Available Methane produced by methanogenic archaea in ruminants contributes significantly to anthropogenic greenhouse gas emissions. The host genetic link controlling microbial methane production is unknown and appropriate genetic selection strategies are not developed. We used sire progeny group differences to estimate the host genetic influence on rumen microbial methane production in a factorial experiment consisting of crossbred breed types and diets. Rumen metagenomic profiling was undertaken to investigate links between microbial genes and methane emissions or feed conversion efficiency. Sire progeny groups differed significantly in their methane emissions measured in respiration chambers. Ranking of the sire progeny groups based on methane emissions or relative archaeal abundance was consistent overall and within diet, suggesting that archaeal abundance in ruminal digesta is under host genetic control and can be used to genetically select animals without measuring methane directly. In the metagenomic analysis of rumen contents, we identified 3970 microbial genes of which 20 and 49 genes were significantly associated with methane emissions and feed conversion efficiency respectively. These explained 81% and 86% of the respective variation and were clustered in distinct functional gene networks. Methanogenesis genes (e.g. mcrA and fmdB were associated with methane emissions, whilst host-microbiome cross talk genes (e.g. TSTA3 and FucI were associated with feed conversion efficiency. These results strengthen the idea that the host animal controls its own microbiota to a significant extent and open up the implementation of effective breeding strategies using rumen microbial gene abundance as a predictor for difficult-to-measure traits on a large number of hosts. Generally, the results provide a proof of principle to use the relative abundance of microbial genes in the gastrointestinal tract of different species to predict their influence on traits e

  18. Code development incorporating environmental, safety, and economic aspects of fusion reactors (FY 92--94). Final report

    International Nuclear Information System (INIS)

    Ho, S.K.; Fowler, T.K.; Holdren, J.P.

    1994-01-01

    This is the Final Report for a three-year (FY 92--94) study of the Environmental, Safety, and Economic (ESE) aspects of fusion energy systems, emphasizing development of computerized approaches suitable for incorporation as modules in fusion system design codes. First, as is reported in Section 2, the authors now have operating a simplified but complete environment and safety evaluation code, BESAFE. The first tests of BESAFE as a module of the SUPERCODE, a design optimization systems code at LLNL, are reported in Section 3. Secondly, as reported in Section 4, the authors have maintained a strong effort in developing fast calculational schemes for activation inventory evaluation. In addition to these major accomplishments, considerable progress has been made on research on specific topics as follows. A tritium modeling code TRIDYN was developed in collaboration with the TSTA group at LANL and the Fusion Nuclear Technology group at UCLA. A simplified algorithm has been derived to calculate the transient temperature profiles in the blanket during accidents. The scheme solves iteratively a system of non-linear ordinary differential equations describing about 10 regions of the blanket by preserving energy balance. The authors have studied the physics and engineering aspects of divertor modeling for safety applications. Several modifications in the automation and characterization of environmental and safety indices have been made. They have applied this work to the environmental and safety comparisons of stainless steel with alternative structural materials for fusion reactors. A methodology in decision analysis utilizing influence and decision diagrams has been developed to model fusion reactor design problems. Most of the work during this funding period has been reported in 26 publications including theses, journal publications, conference papers, and technical reports, as listed in Section 11

  19. Structured flowcharts for control logic specification in the Tritium Systems Test Assembly

    International Nuclear Information System (INIS)

    Nielson, C.W.; Claborn, G.W.

    1983-01-01

    The Tritium Systems Test Assembly (TSTA) contains several subsystems employing sophisticated chemical and physical processes to purify, transport, and capture the isotopes of hydrogen. The ultimate responsibility for the correct and safe operation of these subsystems lies with their designers. However, the logic is implemented in a computer system with program control. A means to insure unambiguous specification of the control logic in a form understandable to both the non-programming designers and the software staff was required. The computer programs are written in RATFOR, a language providing clear control structures and powerful symbol definition facilities. However, the actual code was considered unsatisfactory as a means of primary specification by the non-programming designers. On the other hand, simple English language descriptions of the desired behavior were not precise enough to insure correctness. Experimentation with traditional flowcharts proved that they were more difficult to follow than the RATFOR code. On the other hand, the use of structured flowcharts derived from those introduced by Nassi and Shneidermanl have proven to be very powerful. Using simple geometric forms for the basic control structures such as loops and conditional tests, and by using expansion rather than connection as the means of reducing any flowchart to a single page, a specification that is both understandable and precise has been obtained. A computer code automates the production and modification of these flowcharts. Combining these flowcharts with primitive subroutines which hide most of the details of control implementation has provided an effective medium for algorithm specification and validation. Examples of the flowcharts and the language used to specify them will be given

  20. Diagnostics and camera strobe timers for hydrogen pellet injectors

    International Nuclear Information System (INIS)

    Bauer, M.L.; Fisher, P.W.; Qualls, A.L.

    1993-01-01

    Hydrogen pellet injectors have been used to fuel fusion experimental devices for the last decade. As part of developments to improve pellet production and velocity, various diagnostic devices were implemented, ranging from witness plates to microwave mass meters to high speed photography. This paper will discuss details of the various implementations of light sources, cameras, synchronizing electronics and other diagnostic systems developed at Oak Ridge for the Tritium Proof-of-Principle (TPOP) experiment at the Los Alamos National Laboratory's Tritium System Test Assembly (TSTA), a system built for the Oak Ridge Advanced Toroidal Facility (ATF), and the Tritium Pellet Injector (TPI) built for the Princeton Tokamak Fusion Test Reactor (TFTR). Although a number of diagnostic systems were implemented on each pellet injector, the emphasis here will be on the development of a synchronization system for high-speed photography using pulsed light sources, standard video cameras, and video recorders. This system enabled near real-time visualization of the pellet shape, size and flight trajectory over a wide range of pellet speeds and at one or two positions along the flight path. Additionally, the system provides synchronization pulses to the data system for pseudo points along the flight path, such as the estimated plasma edge. This was accomplished using an electronic system that took the time measured between sets of light gates, and generated proportionally delayed triggers for light source strobes and pseudo points. Systems were built with two camera stations, one located after the end of the barrel, and a second camera located closer to the main reactor vessel wall. Two or three light gates were used to sense pellet velocity and various spacings were implemented on the three experiments. Both analog and digital schemes were examined for implementing the delay system. A digital technique was chosen

  1. Annual report of the Naka Fusion Research Establishment for the period of April 1, 1985 to March 31, 1986

    International Nuclear Information System (INIS)

    1987-02-01

    Research and development activities of the Naka Fusion Research Establishment for the period of April 1985 to March 1986 are described. The JT-60 tokamak machine was completed in April 1985 after a seven-year construction period, and the first plasma operation was achieved on April 8, 1985. Initial experiments with Joule-heated plasmas were performed for three months from April to June 1985 and confirmed tokamak discharges of sufficient plasma current and density as required for additional heating in the divertor configuration. In JFT-2M experiments on beam and ICRF heated plasmas, H-mode discharges with good confinement characteristics were achieved in open divertor configurations. The Doublet III device had been modified into D-III D with a large deeshaped cross-section. The first plasma was obtained in February 1986. The development of a numerical tokamak code TRITON-II was continued. Plasma-surface interaction studies and vacuum technology development were continued. In the study of plasma heating technology, programmable control of the neutral beam energy was demonstrated in a proto-type injector unit. Negative hydrogen ion beams of 25 keV, 0.1 A were extracted by using multiaperture extraction grid. Research was also carried out on improvements of RF coupling system with emphasis on RF breakdown phenomena in a pill box type ceramic window. In the development of superconducting magnets, generation of a 12T magnetic field was demonstrated by the Test Module Coils. The fabrication of the Demonstration Poloidal Coil was started. Preliminary tritium tests on JAERI's proto-type Pd-diffuser and ceramic electrolysis cell had been successfully carried out in the TSTA at LANL. The design study of the Fusion Experimental Reactor was continued. A wide range of scoping studies was also made to evaluate cost/benefits effects. INTOR design studies were concentrated on tokamak innovations. (J.P.N.)

  2. Application of the water gas shift reaction to fusion fuel exhaust streams

    International Nuclear Information System (INIS)

    McKay, A.M.; Cheh, C.H.; Glass, R.W.

    1983-10-01

    In a Fusion Fuel Clean Up (FCU) system, impurities will be removed from the fusion reactor exhaust and neutral beam line streams. Tritium in this impurity stream will be recovered and recycled to the fuel stream. In one flowsheet configuration of the Tritium Systems Test Assembly (TSTA), tritium is recovered from a simulated impurity stream via uranium hot metal beds and recycled to an isotope separation system. This study has shown, however, that the catalyzed water gas shift reaction, by which (H,D,T) 2 O and CO are converted to (H,D,T) 2 and CO 2 is a better method of (H,D,T) 2 O reduction than the hot metal beds. Catalytic reactors were designed, built and tested to provide data for the design of a prototype reactor to replace the hot metal beds in the FCU system. The prototype reactor contains only 10 g of catalyst and is expected to last at least 5 years. The reactor is small (1.3 cm OD x 13 cm long), operates at low temperatures (approximately 490 K) and will convert water to hydrogen, at a CO/H 2 O ratio of 1.5, with an efficiency of greater than 98 percent. Results show that the catalytic reactor is very stable even during upset conditions. Wide ranges of flow and a CO/H 2 O ratio variance from 1.3 upward have little effect on the conversion efficiency. Short term high temperature excursions do not affect the catalyst and lower temperatures will simply decrease the reaction rate resulting in lower conversions. The reactor appears to be unaffected by NO 2 , CO 2 , O 2 and N 2 in the feed stream at concentration levels expected in a fusion reactor exhaust stream

  3. Formações venosas superficiais da fossa cubital: aspectos de interesse para a prática da Enfermagem

    Directory of Open Access Journals (Sweden)

    Nilton Alves

    Full Text Available O objetivo deste estudo é contribuir para o conhecimento que auxilie o profissional de enfermagem na identificação dos tipos mais comuns de formações venosas da região da fossa cubital e, ainda, enfocar a importância de estar sempre atento aos casos pouco comuns como o aqui relatado. Através de uma revisão bibliográfica, constatamos que as formações venosas dessa região podem ser classificadas em 5 tipos mais comuns, sendo o tipo II o mais frequente. Constatamos ainda, que a VICo é o local de punção mais indicado, seguido pela VIB. Descrevemos também uma variação anatômica, onde observamos ausência de comunicação entre VC e VB no nível da fossa cubital e VIA drenando na VB, estando presente a VCA.

  4. Interaction between compressible fluid and sound in a flue instrument

    International Nuclear Information System (INIS)

    Kobayashi, Taizo; Aoyagi, Mutsumi; Akamura, Takahiro; Iwasaki, Takuya; Nakano, Ken'ichiro; Takahashi, Kin'ya; Nagao, Yuki

    2014-01-01

    In order to study the generation of (aerodynamic) sound in flue instruments, we numerically apply Howe's energy corollary for a two-dimensional model of a flue instrument. Howe's energy corollary enables us to estimate the energy transfer between the fluid flow and acoustic field. To implement it, separating the acoustic field from the fluid flow is needed. However the complete method to numerically achieve it has not been established yet. In this work, we develop an approximate method, which has been recently proposed in their experimental studies by Yoshikawa et al (2012 J. Sound Vib. 331 2558–77) and others, and we apply it to the simulation of the model instrument. We first calculate fluid flow and acoustic oscillation simultaneously by a compressible fluid solver. Next referring to the information on the acoustic oscillation obtained we set up a pressure source on an acoustic solver and reproduce almost the same acoustic oscillation with it. Combining those results, we are able to calculate Howe's energy corollary. The numerical result shows that the aerodynamic sound is generated from the oscillating jet rather than the vortices shed by the collision of it with the edge of the mouth opening, namely vortex shedding. (paper)

  5. Ceramic protective coating

    International Nuclear Information System (INIS)

    Harbach, F.; Nicoll, A.

    1987-01-01

    The basic material of the above-mentioned layer consists of pure aluminium oxide or essentially aluminium oxide. To improve this protective layer metal oxides from the groups IIA, IIIA, IIIB, VB, VIB, VIIB or VIII of the periodic system are added to its basic material before the said protective coating is applied. In this way a corundum structure is formed in the case of aluminium oxide. Gallium oxide, vanadium oxide, chromium oxide or iron oxide are particularly suited for the correlation of such a corundum structure. The formation of the corundum structure increases the resistance of the protective coating to the corrosive effects of vanadium pentoxide and sodium sulfate. By the addition of a specific quantity of magnesium oxide it is possible not only to stimulate the formation of corundum but also to reduce the increase in grain size in the case of the aluminium oxide. The other metallic oxides are especially favorable to the formation of the corundum structure, so that preferably magnesium oxide is to be added to these metallic oxides in order to reduce the increase in grain size. (author)

  6. Strength and Debye temperature measurements of cerium across the γ → α volume collapse: the lattice contribution

    International Nuclear Information System (INIS)

    Lipp, M J; Jenei, Zs; Cynn, H; Aracne-Ruddle, C; Evans, W J; Kono, Y; Park, C; Kenney-Benson, C

    2013-01-01

    The longitudinal and transverse sound speeds, c L and c T , of polycrystalline cerium were measured under pressure across the iso-structural γ–α phase transition at 0.75 GPa to beyond 3 GPa. In contrast to previous methods all quantities were directly obtained and no assumptions were made about the size of the volume collapse. Up to the transition our values for c L are in excellent agreement with previous ones, while our values for c T are significantly lower. We deduce values for the adiabatic bulk modulus B S , the shear modulus G=ρc(2)/T, and the pressure dependent Debye temperature, Θ D (p). Θ D (p) is in good agreement with recent results derived from phonon dispersion measurements on single crystals. The ratio of the Debye temperature values bracketing the transition indicates a lattice contribution to the entropy change across the volume collapse, ΔS vib (γ → α) ≈ (0.68 ± 0.06)k B , consistent with previous results obtained by neutron scattering, but significantly larger than other previously determined values. (paper)

  7. Nonredundant Roles of Iron Acquisition Systems in Vibrio cholerae.

    Science.gov (United States)

    Peng, Eric D; Wyckoff, Elizabeth E; Mey, Alexandra R; Fisher, Carolyn R; Payne, Shelley M

    2016-02-01

    Vibrio cholerae, the causative agent of the severe diarrheal disease cholera, thrives in both marine environments and the human host. To do so, it must encode the tools necessary to acquire essential nutrients, including iron, under these vastly different conditions. A number of V. cholerae iron acquisition systems have been identified; however, the precise role of each system is not fully understood. To test the roles of individual systems, we generated a series of mutants in which only one of the four systems that support iron acquisition on unsupplemented LB agar, Feo, Fbp, Vct, and Vib, remains functional. Analysis of these mutants under different growth conditions showed that these systems are not redundant. The strain carrying only the ferrous iron transporter Feo grew well at acidic, but not alkaline, pH, whereas the ferric iron transporter Fbp promoted better growth at alkaline than at acidic pH. A strain defective in all four systems (null mutant) had a severe growth defect under aerobic conditions but accumulated iron and grew as well as the wild type in the absence of oxygen, suggesting the presence of an additional, unidentified iron transporter in V. cholerae. In support of this, the null mutant was only moderately attenuated in an infant mouse model of infection. While the null mutant used heme as an iron source in vitro, we demonstrate that heme is not available to V. cholerae in the infant mouse intestine. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

  8. Mud-plastered granary-baskets at a Celtic Oppidum near Čarnok (Vojvodina, Serbia

    Directory of Open Access Journals (Sweden)

    Medović Aleksandar

    2011-01-01

    Full Text Available In the Celtic Oppidum near Čarnok (Bačka, Vojvodina, Serbia remains of four mud-plastered granarybaskets were discovered. They are all dated to the period Gomolava VI-B (first half of the 1st century B.C.. Hulled barley and broomcorn millet were stored in the granary-baskets. The mesh of the granary-baskets was composed of young branches of oak tree (Quercus, common English elm tree (Ulmus cf. campestris L., poplar / willow (Populus / Salix, purgin buckthorn (Rhamnus cf. cathartica L., wayfaring tree (Viburnum cf. lantana L., spindle tree (Euonymus cf. europaeus L., barberry (Berberis vulgaris L. and a Pomoidae-tree. At least four different tree taxa were used for basket making. Construction of two-thousand-year old mud-plastered granary-baskets from the Pannonian plain is very similar to that of traditional granaries in some present-day villages in Africa. Additionally, one non-plastered basket was also discovered at Oppidum. It was build out of maple (Acer, barberry, buckthorn (Rhamnus and branches of a pomaceous fruits tree (Pomoidae. .

  9. Expansion of an exotic species and concomitant disease outbreaks: pigeon paramyxovirus in free-ranging Eurasian collared doves

    Science.gov (United States)

    Schuler, Krysten L.; Green, David E.; Justice-Allen, Anne E.; Jaffe, Rosemary; Cunningham, Mark; Thomas, Nancy J.; Spalding, Marilyn G.; Ip, Hon S.

    2012-01-01

    Eurasian collared doves (Streptopelia decaocto) have expanded their range across the United States since their introduction several decades ago. Recent mortality events in Eurasian collared doves in Arizona and Montana, USA, during the winter of 2009-2010 were the result of pigeon paramyxovirus (PPMV), a novel disease agent. The first instance of mortality by this emerging infectious disease in this species occurred in Florida in 2001 with subsequent disease events in 2006 and 2008. Full diagnostic necropsies were performed on carcasses from the three states. PPMV was identified by RT-PCR and virus isolation and was sequenced to the VIb genotype of avian paramyxovirus-1 (APMV). Other APMVs are common in a variety of free-ranging birds, but concern is warranted because of the potential for commingling of this species with native birds, virus evolution, and threats to domestic poultry. Improved surveillance for wildlife mortality events and efforts to prevent introduction of non-native animals could reduce the threat of introducing new pathogens.

  10. Vibrational spectral investigation on xanthine and its derivatives--theophylline, caffeine and theobromine.

    Science.gov (United States)

    Gunasekaran, S; Sankari, G; Ponnusamy, S

    2005-01-01

    A normal coordinate analysis has been carried out on four compounds having a similar ring structure with different side chain substitutions, which are xanthine, caffeine, theophylline, and theobromine. Xanthine is chemically known as 2,6-dihydroxy purine. Caffeine, theophylline and theobromine are methylated xanthines. Considering the methyl groups as point mass, the number of normal modes of vibrations can be distributed as Gamma(vib) = 27 A' + 12 A" based on C(s) point group symmetry associated with the structures. In the present work 15 A' and 12 A'' normal modes are considered. A new set of orthonormal symmetry co-ordinates have been constructed. Wilson's F-G matrix method has been adopted for the normal coordinate analysis. A satisfactory vibrational band assignment has been made by employing the FTIR and FT Raman spectra of the compounds. The potential energy distribution is calculated with the arrived values of the force constants and hence the agreement of the frequency assignment has been checked.

  11. Formações venosas superficiais da fossa cubital: aspectos de interesse para a prática da Enfermagem

    Directory of Open Access Journals (Sweden)

    Nilton Alves

    2012-12-01

    Full Text Available O objetivo deste estudo é contribuir para o conhecimento que auxilie o profissional de enfermagem na identificação dos tipos mais comuns de formações venosas da região da fossa cubital e, ainda, enfocar a importância de estar sempre atento aos casos pouco comuns como o aqui relatado. Através de uma revisão bibliográfica, constatamos que as formações venosas dessa região podem ser classificadas em 5 tipos mais comuns, sendo o tipo II o mais frequente. Constatamos ainda, que a VICo é o local de punção mais indicado, seguido pela VIB. Descrevemos também uma variação anatômica, onde observamos ausência de comunicação entre VC e VB no nível da fossa cubital e VIA drenando na VB, estando presente a VCA.

  12. [Regulation of publicity for children's food as a strategy for promotion of health].

    Science.gov (United States)

    Henriques, Patrícia; Sally, Enilce Oliveira; Burlandy, Luciene; Beiler, Renata Mondino

    2012-02-01

    The eating habits of the Brazilian population have been changing in recent decades and publicity is one of the factors contributing to this situation. The objective of this study was to evaluate the content of food publicity broadcast on television and addressed to children, from the standpoint of regulation. The publicity broadcast on the two major television stations during the school holidays was recorded on VHS tapes. Content analysis techniques were used and eight categories of analysis were defined based on the theoretical benchmark of the eating habits and their determining factors. The proposal for a Technical Regulation of Anvisa was used to conduct this analysis. 1018 advertisements were recorded, of which 132 (12.9%) that advertised foods targeted at children were selected, but only 12 different products were identified. According to the proposed regulation, all the material analyzed violated no less than three articles, among which the 4th, Sections III and VIb stand out. The pressing need for government regulation of the content of food advertisements for children, the consumption of which can be harmful to health, is clearly apparent because of its influence on the decision to purchase, both by the children themselves, and their parents.

  13. The improvement of a simple theoretical model for the prediction of the sound insulation of double leaf walls.

    Science.gov (United States)

    Davy, John L

    2010-02-01

    This paper presents a revised theory for predicting the sound insulation of double leaf cavity walls that removes an approximation, which is usually made when deriving the sound insulation of a double leaf cavity wall above the critical frequencies of the wall leaves due to the airborne transmission across the wall cavity. This revised theory is also used as a correction below the critical frequencies of the wall leaves instead of a correction due to Sewell [(1970). J. Sound Vib. 12, 21-32]. It is found necessary to include the "stud" borne transmission of the window frames when modeling wide air gap double glazed windows. A minimum value of stud transmission is introduced for use with resilient connections such as steel studs. Empirical equations are derived for predicting the effective sound absorption coefficient of wall cavities without sound absorbing material. The theory is compared with experimental results for double glazed windows and gypsum plasterboard cavity walls with and without sound absorbing material in their cavities. The overall mean, standard deviation, maximum, and minimum of the differences between experiment and theory are -0.6 dB, 3.1 dB, 10.9 dB at 1250 Hz, and -14.9 dB at 160 Hz, respectively.

  14. The discovery of a highly polarized bipolar nebula

    International Nuclear Information System (INIS)

    Wolstencroft, R.D.; Scarrott, S.M.; Menzies, J.

    1989-01-01

    During a search for the optical counterparts of IRAS sources whose flux peaks at 25 microns, a small faint bipolar nebula was discovered in Monoceros at the position of IRAS 07131-0147. The CCD images display the object's considerable structure. The central star seems relatively free of closeby nebulosity: the two lobes have a bow-tie structure with those parts nearest to the star consisting of series of small knots. The outer parts of the lobes seem to be made up of filaments streaming away from knots. On the basis of its optical spectrum, the central star was classified as a M5-6 giant. In the IRAS color classification scheme of Van der Veen and Habing (1988), the central star is VIb which indicates that there are distinct hot and cold components of circumstellar dust and that the mass loss process may have temporarily abated. Therefore, it is proposed that the object is in the post main sequence stage of evolution and is a protoplanetary nebulae. Young protoplanetary nebulae have totally obscured central stars illuminating reflective lobes whereas older ones such as M2-9 have lobes seen in emission from gas ionized by the central hot star which is clearly visible. Since the central object of IRAS07131-0147 is a relatively unobscured late type star and the lobes are seen only by reflection, it is suggested that this nebula is a protoplanetary nebula in an evolutionary stage intermediate between that of CRL2688 and M2-9

  15. Longitudinal surveys on effects of changes in road traffic noise-annoyance, activity disturbances, and psycho-social well-being

    Science.gov (United States)

    Öhrström, Evy

    2004-02-01

    The adverse effects of long-term exposure to a high volume of road traffic were studied in socio-acoustic surveys in 1997 and in 1999 after a substantial reduction in road traffic. The results obtained in 1997 showed a similar response pattern as in previously performed studies in the area in 1986 [Öhrström, J. Sound Vib. 122, 277-290 (1989)]. In 1999, road traffic had been reduced from 25 000 to 2400 vehicles per day, and this resulted not only in a large decrease in annoyance and activity disturbances, but also in a better general well-being. The results suggest that a reduction in both noise and other pollutants from road traffic contribute to these effects. To be able to use the outdoor environment and to have the possibility to keep windows open is essential for general well-being and daily behavior, which implies that access both to quiet indoor and outdoor sections of the residency is of importance for achievement of a healthy sound environment. More knowledge of long-term health consequences of exposure to noise and simultaneous pollutants from road traffic is needed. Studies should focus more on ``softer'' health outcomes and well-being than hitherto and preferably be performed in connection with traffic abatement measures.

  16. Phylogenetic analysis of some Newcastle disease virus isolates from the Sudan

    Directory of Open Access Journals (Sweden)

    N.A. Elmardi

    2016-06-01

    Full Text Available A reverse transcription-polymerase chain reaction (RT-PCR was used to amplify 1412 bp of the fusion protein gene (F gene of four Newcastle disease virus (NDV isolates; two velogenic (TY-1/90 and DIK-90 and two lentogenic isolates (Dongla 88/1 and GD.S.1. Following sequencing, nucleotide sequences were annotated and 894 bp were compared phylogenetically with those from strains previously reported in the Sudan and the virus strains published on the GenBank. It could be demonstrated that TY-1/90 and DIK-90 strains belong to the genotype VI of NDV and are in close genetic relationship to sub- genotype VIb. TY-1/90 and DIK-90 strains were observed to be genetically unrelated to the earlier Sudanese isolates of 1970/80s and the late of 2000s suggesting a different origin. The close genetic relationship to the European and African pigeon paramyxovirus type 1 (PPMV-1 suggests a common ancestor. Dongola, GD.S.1 strains were classified into genotype II that comprises non-pathogenic lentogenic NDV strains. The present genetic classification of NDV isolates of the Sudan provides valuable information on genotypes of NDV. Further molecular epidemiological investigations of the recent outbreaks of Newcastle disease in the Sudan are needed in order to improve the efficiency of control strategies and vaccine development.

  17. Methods of forming single source precursors, methods of forming polymeric single source precursors, and single source precursors formed by such methods

    Science.gov (United States)

    Fox, Robert V.; Rodriguez, Rene G.; Pak, Joshua J.; Sun, Chivin; Margulieux, Kelsey R.; Holland, Andrew W.

    2014-09-09

    Methods of forming single source precursors (SSPs) include forming intermediate products having the empirical formula 1/2{L.sub.2N(.mu.-X).sub.2M'X.sub.2}.sub.2, and reacting MER with the intermediate products to form SSPs of the formula L.sub.2N(.mu.-ER).sub.2M'(ER).sub.2, wherein L is a Lewis base, M is a Group IA atom, N is a Group IB atom, M' is a Group IIIB atom, each E is a Group VIB atom, each X is a Group VIIA atom or a nitrate group, and each R group is an alkyl, aryl, vinyl, (per)fluoro alkyl, (per)fluoro aryl, silane, or carbamato group. Methods of forming polymeric or copolymeric SSPs include reacting at least one of HE.sup.1R.sup.1E.sup.1H and MER with one or more substances having the empirical formula L.sub.2N(.mu.-ER).sub.2M'(ER).sub.2 or L.sub.2N(.mu.-X).sub.2M'(X).sub.2 to form a polymeric or copolymeric SSP. New SSPs and intermediate products are formed by such methods.

  18. Methods of forming single source precursors, methods of forming polymeric single source precursors, and single source precursors and intermediate products formed by such methods

    Science.gov (United States)

    Fox, Robert V.; Rodriguez, Rene G.; Pak, Joshua J.; Sun, Chivin; Margulieux, Kelsey R.; Holland, Andrew W.

    2012-12-04

    Methods of forming single source precursors (SSPs) include forming intermediate products having the empirical formula 1/2{L.sub.2N(.mu.-X).sub.2M'X.sub.2}.sub.2, and reacting MER with the intermediate products to form SSPs of the formula L.sub.2N(.mu.-ER).sub.2M'(ER).sub.2, wherein L is a Lewis base, M is a Group IA atom, N is a Group IB atom, M' is a Group IIIB atom, each E is a Group VIB atom, each X is a Group VIIA atom or a nitrate group, and each R group is an alkyl, aryl, vinyl, (per)fluoro alkyl, (per)fluoro aryl, silane, or carbamato group. Methods of forming polymeric or copolymeric SSPs include reacting at least one of HE.sup.1R.sup.1E.sup.1H and MER with one or more substances having the empirical formula L.sub.2N(.mu.-ER).sub.2M'(ER).sub.2 or L.sub.2N(.mu.-X).sub.2M'(X).sub.2 to form a polymeric or copolymeric SSP. New SSPs and intermediate products are formed by such methods.

  19. Cytochrome c oxidase loses catalytic activity and structural integrity during the aging process in Drosophila melanogaster

    International Nuclear Information System (INIS)

    Ren, Jian-Ching; Rebrin, Igor; Klichko, Vladimir; Orr, William C.; Sohal, Rajindar S.

    2010-01-01

    Research highlights: → Cytochrome c oxidase loses catalytic activity during the aging process. → Abundance of seven nuclear-encoded subunits of cytochrome c oxidase decreased with age in Drosophila. → Cytochrome c oxidase is specific intra-mitochondrial site of age-related deterioration. -- Abstract: The hypothesis, that structural deterioration of cytochrome c oxidase (CcO) is a causal factor in the age-related decline in mitochondrial respiratory activity and an increase in H 2 O 2 generation, was tested in Drosophila melanogaster. CcO activity and the levels of seven different nuclear DNA-encoded CcO subunits were determined at three different stages of adult life, namely, young-, middle-, and old-age. CcO activity declined progressively with age by 33%. Western blot analysis, using antibodies specific to Drosophila CcO subunits IV, Va, Vb, VIb, VIc, VIIc, and VIII, indicated that the abundance these polypeptides decreased, ranging from 11% to 40%, during aging. These and previous results suggest that CcO is a specific intra-mitochondrial site of age-related deterioration, which may have a broad impact on mitochondrial physiology.

  20. Cytochrome c oxidase loses catalytic activity and structural integrity during the aging process in Drosophila melanogaster

    Energy Technology Data Exchange (ETDEWEB)

    Ren, Jian-Ching; Rebrin, Igor [Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90033 (United States); Klichko, Vladimir; Orr, William C. [Department of Biological Sciences, Southern Methodist University, Dallas, TX 75275 (United States); Sohal, Rajindar S., E-mail: sohal@usc.edu [Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90033 (United States)

    2010-10-08

    Research highlights: {yields} Cytochrome c oxidase loses catalytic activity during the aging process. {yields} Abundance of seven nuclear-encoded subunits of cytochrome c oxidase decreased with age in Drosophila. {yields} Cytochrome c oxidase is specific intra-mitochondrial site of age-related deterioration. -- Abstract: The hypothesis, that structural deterioration of cytochrome c oxidase (CcO) is a causal factor in the age-related decline in mitochondrial respiratory activity and an increase in H{sub 2}O{sub 2} generation, was tested in Drosophila melanogaster. CcO activity and the levels of seven different nuclear DNA-encoded CcO subunits were determined at three different stages of adult life, namely, young-, middle-, and old-age. CcO activity declined progressively with age by 33%. Western blot analysis, using antibodies specific to Drosophila CcO subunits IV, Va, Vb, VIb, VIc, VIIc, and VIII, indicated that the abundance these polypeptides decreased, ranging from 11% to 40%, during aging. These and previous results suggest that CcO is a specific intra-mitochondrial site of age-related deterioration, which may have a broad impact on mitochondrial physiology.

  1. Application of dragonfly algorithm for optimal performance analysis of process parameters in turn-mill operations- A case study

    Science.gov (United States)

    Vikram, K. Arun; Ratnam, Ch; Lakshmi, VVK; Kumar, A. Sunny; Ramakanth, RT

    2018-02-01

    Meta-heuristic multi-response optimization methods are widely in use to solve multi-objective problems to obtain Pareto optimal solutions during optimization. This work focuses on optimal multi-response evaluation of process parameters in generating responses like surface roughness (Ra), surface hardness (H) and tool vibration displacement amplitude (Vib) while performing operations like tangential and orthogonal turn-mill processes on A-axis Computer Numerical Control vertical milling center. Process parameters like tool speed, feed rate and depth of cut are considered as process parameters machined over brass material under dry condition with high speed steel end milling cutters using Taguchi design of experiments (DOE). Meta-heuristic like Dragonfly algorithm is used to optimize the multi-objectives like ‘Ra’, ‘H’ and ‘Vib’ to identify the optimal multi-response process parameters combination. Later, the results thus obtained from multi-objective dragonfly algorithm (MODA) are compared with another multi-response optimization technique Viz. Grey relational analysis (GRA).

  2. Impact of Alloying on Stacking Fault Energies in γ-TiAl

    Directory of Open Access Journals (Sweden)

    Phillip Dumitraschkewitz

    2017-11-01

    Full Text Available Microstructure and mechanical properties are key parameters influencing the performance of structural multi-phase alloys such as those based on intermetallic TiAl compounds. There, the main constituent, a γ -TiAl phase, is derived from a face-centered cubic structure. Consequently, the dissociation of dislocations and generation of stacking faults (SFs are important factors contributing to the overall deformation behavior, as well as mechanical properties, such as tensile/creep strength and, most importantly, fracture elongation below the brittle-to-ductile transition temperature. In this work, SFs on the { 111 plane in γ -TiAl are revisited by means of ab initio calculations, finding their energies in agreement with previous reports. Subsequently, stacking fault energies are evaluated for eight ternary additions, namely group IVB–VIB elements, together with Ti off-stoichiometry. It is found that the energies of superlattice intrinsic SFs, anti-phase boundaries (APBs, as well as complex SFs decrease by 20–40% with respect to values in stoichiometric γ -TiAl once an alloying element X is present in the fault plane having thus a composition of Ti-50Al-12.5X. In addition, Mo, Ti and V stabilize the APB on the (111 plane, which is intrinsically unstable at 0 K in stoichiometric γ -TiAl.

  3. Analysis of airborne flux measurements of heat, moisture and carbon dioxide, and their correlation with land cover types in BOREAS

    Science.gov (United States)

    Ogunjemiyo, Segun Ojo

    The landscape of the boreal forest in north-central Canada is characterised by mosaics of broad-leaved deciduous trees (aspen, Populus; birch, Betula), evergreen conifers (black spruce, Picea mariana; jack pine, Pinus banksiana; and larch, Larix), fens and lakes. The forest has been cited as the possible location of a global carbon sink, and its likely response in the event of global climate change remains unclear. To improve our current understanding of the links between the boreal forest ecosystem and the lower atmosphere, the Boreal Ecosystem- Atmosphere Study (BOREAS) was executed in a series of field experiments in 1994 and 1996. This thesis documents the efforts made to characterise and map temporal and spatial distributions of the fluxes of heat, water vapour and CO2 over two 16 km x 16 km heterogeneous sites at the BOREAS study sites. Most of the data in this thesis were obtained from the airborne observations by the Canadian Twin Otter Aircraft, operated by the Institute for Aerospace Research of the Canadian National Research Council, at the BOREAS Northern Study Area (NSA), and Southern Study Area (SSA). The research aircraft was flown at a fixed altitude of about 30 m agl. The data acquired in 1994 were primarily used to develop an objective deterending scheme in eddy-correlation flux estimates, that took into consideration the physical nature of turbulent transport during convective daytime conditions, and to map the spatial distribution of sensible heat, latent heat and CO2 fluxes over three intensive field campaigns. Maps of spatial patterns of the surface characteristics, such as the surface temperature excess over air temperature (Ts-T a) and Greenness index (GI), were also constructed. The mapping procedure involved generation of an array of grid points by block averaging the parameter of interests along the flight lines, spaced 2 km apart, over 2 km windows, with 1 km overlap between adjacent windows. The (Ts-Ta) maps showed, not surprisingly

  4. Formações venosas superficiais da fossa cubital: aspectos de interesse para a prática da Enfermagem Formaciones venosas superficiales de la fosa cubital: aspectos de interés para la práctica de Enfermería Superficial venous formation of the cubital fossa: aspects of interest for nursing practice

    Directory of Open Access Journals (Sweden)

    Nilton Alves

    2012-12-01

    Full Text Available O objetivo deste estudo é contribuir para o conhecimento que auxilie o profissional de enfermagem na identificação dos tipos mais comuns de formações venosas da região da fossa cubital e, ainda, enfocar a importância de estar sempre atento aos casos pouco comuns como o aqui relatado. Através de uma revisão bibliográfica, constatamos que as formações venosas dessa região podem ser classificadas em 5 tipos mais comuns, sendo o tipo II o mais frequente. Constatamos ainda, que a VICo é o local de punção mais indicado, seguido pela VIB. Descrevemos também uma variação anatômica, onde observamos ausência de comunicação entre VC e VB no nível da fossa cubital e VIA drenando na VB, estando presente a VCA.El objetivo de esta investigación es contribuir al conocimiento que auxilie al profesional de enfermería en la identificación de los tipos más comunes de formaciones venosas de la fosa cubital, además de advertir sobre la importancia de fijar la atención a los casos poco comunes, como lo aquí reportado. A través de la revisión bibliográfica, clasificamos las formaciones venosas de esta región en cinco tipos más comunes, siendo lo más frecuente el Tipo II. La utilización de la VICo se recomienda como el mejor sitio de punción, seguido por la VIB. Además, describimos una variación anatómica, donde se observó la ausencia de comunicación entre VC y VB a nivel de fosa cubital y VIA drenando en VB, con presencia de la VCA.The aim of this study is to contribute to the knowledge to assists the nursing staff to identify the most common types of venous formations of the cubital fossa region, and also focus on the importance of always being alert to unusual cases as that reported here. Through a literature review, we found that the venous formations of this region can be classified into five common types, bring the Type II the was most frequent. We also found that MCV is considered the best puncture site, followed by MBV

  5. Regulamentação da propaganda de alimentos infantis como estratégia para a promoção da saúde Regulation of publicity for children's food as a strategy for promotion of health

    Directory of Open Access Journals (Sweden)

    Patrícia Henriques

    2012-02-01

    Full Text Available As práticas alimentares da população brasileira vêm se alterando nas últimas décadas e a publicidade é um dos fatores que contribuem para esta situação. O objetivo deste trabalho foi avaliar o conteúdo das propagandas de alimentos veiculadas na televisão e dirigidas a crianças, sob a ótica da regulação. As propagandas foram gravadas em fitas VHS de duas grandes emissoras de televisão, no período de férias escolares. Foram utilizadas técnicas de análise de conteúdo e definidas oito categorias de análise a partir do referencial teórico sobre as práticas alimentares e seus determinantes. Para subsidiar a análise utilizou-se a proposta de Regulamento Técnico da Anvisa. Foram contabilizadas 1018 propagandas, das quais foram selecionadas as 132 (12,9% que anunciavam alimentos dirigidos para as crianças, sendo identificados somente 12 produtos diferentes. De acordo com o Regulamento proposto, todas as propagandas analisadas infringiam pelo menos três artigos, entre os quais se destaca o 4º, Incisos III e VIb. É nítida a urgência do setor público de regular o conteúdo das propagandas de alimentos infantis, cujo consumo pode ser prejudicial à saúde devido à influência que exercem na decisão pela compra, tanto por parte das próprias crianças, quanto dos pais.The eating habits of the Brazilian population have been changing in recent decades and publicity is one of the factors contributing to this situation. The objective of this study was to evaluate the content of food publicity broadcast on television and addressed to children, from the standpoint of regulation. The publicity broadcast on the two major television stations during the school holidays was recorded on VHS tapes. Content analysis techniques were used and eight categories of analysis were defined based on the theoretical benchmark of the eating habits and their determining factors. The proposal for a Technical Regulation of Anvisa was used to conduct

  6. Core-level spectra and binding energies of transition metal nitrides by non-destructive x-ray photoelectron spectroscopy through capping layers

    Energy Technology Data Exchange (ETDEWEB)

    Greczynski, G., E-mail: grzgr@ifm.liu.se [Thin Film Physics Division, Department of Physics (IFM), Linköping University, SE-581 83 Linköping (Sweden); Primetzhofer, D. [Department of Physics and Astronomy, The Ångström Laboratory, Uppsala University, P.O. Box 516, SE-751 20 Uppsala (Sweden); Lu, J.; Hultman, L. [Thin Film Physics Division, Department of Physics (IFM), Linköping University, SE-581 83 Linköping (Sweden)

    2017-02-28

    Highlights: • First non-destructive measurements of XPS core level binding energies for group IVb-VIb transition metal nitrides are presented. • All films are grown under the same conditions and analyzed in the same instrument, providing a useful reference for future XPS studies. • Extracted core level BE values are more reliable than those obtained from sputter-cleaned N-deficient surfaces. • Comparison to Ar+-etched surfaces reveals that even mild etching conditions result in the formation of a nitrogen-deficient surface layer. • The N/metal concentration ratios from capped samples are found to be 25-90% higher than those from the corresponding ion-etched surfaces. - Abstract: We present the first measurements of x-ray photoelectron spectroscopy (XPS) core level binding energies (BE:s) for the widely-applicable group IVb-VIb polycrystalline transition metal nitrides (TMN’s) TiN, VN, CrN, ZrN, NbN, MoN, HfN, TaN, and WN as well as AlN and SiN, which are common components in the TMN-based alloy systems. Nitride thin film samples were grown at 400 °C by reactive dc magnetron sputtering from elemental targets in Ar/N{sub 2} atmosphere. For XPS measurements, layers are either (i) Ar{sup +} ion-etched to remove surface oxides resulting from the air exposure during sample transfer from the growth chamber into the XPS system, or (ii) in situ capped with a few nm thick Cr or W overlayers in the deposition system prior to air-exposure and loading into the XPS instrument. Film elemental composition and phase content is thoroughly characterized with time-of-flight elastic recoil detection analysis (ToF-E ERDA), Rutherford backscattering spectrometry (RBS), and x-ray diffraction. High energy resolution core level XPS spectra acquired with monochromatic Al Kα radiation on the ISO-calibrated instrument reveal that even mild etching conditions result in the formation of a nitrogen-deficient surface layer that substantially affects the extracted binding energy

  7. Co-circulation of paramyxo- and influenza viruses in pigeons in Egypt.

    Science.gov (United States)

    Mansour, Shimaa M G; Mohamed, Fakry F; Eid, Amal A M; Mor, Sunil K; Goyal, Sagar M

    2017-08-01

    In recent years, avian influenza virus (AIV) and Newcastle disease virus (NDV) have caused large-scale outbreaks in many countries, including Egypt. The culling and vaccination strategies have failed to control both viruses in Egypt. In this study, we investigated the outbreaks of nervous manifestations and deaths in pigeons between 2013 and 2015. The H5N1 subtype of the highly pathogenic avian influenza virus and pigeon paramyxovirus-1, an antigenic variant of NDV, were found to be the cause; AIV and pigeon paramyxovirus-1 were isolated from 61.3% (19/31) and 67.8% (21/31) of tested pigeons, respectively. Co-infection with both viruses was detected in 51.6% of pigeons (16/31). The AIV sequences showed PQGEKRRKKR/GLF motif at the haemagglutinin gene cleavage site, which is typical of the highly pathogenic H5N1 subtype. The phylogenetic tree showed that the highly pathogenic avian influenza belonged to clade 2.2.1.2. The NDV sequences carried one of the three motifs, 112 GKQGRL 117 , 112 KRQKRF 117 or 112 RRQKRF 117 , at the fusion protein cleavage site and were classified as genotypes I, VI and II in NDV-class II, respectively. This indicated that different genotypes of NDV can circulate simultaneously among pigeons. Further analysis revealed the clustering of some sequences in sub-genotypes Ia and VIb.2. To the best of our knowledge, these sub-genotypes have not been previously reported from pigeons in Egypt. Our results should serve as a base for future studies on both viruses in Egypt.

  8. Effects of Mo-doping on microstructure and near-infrared shielding performance of hydrothermally prepared tungsten bronzes

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Qingjuan; Li, Can; Xu, Wenai; Zhao, Xiaolin; Zhu, Jingxin [Laboratory of Green Energy Materials and Storage Systems, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024 (China); Jiang, Haiwei, E-mail: tyjmx@163.com [Laboratory of Green Energy Materials and Storage Systems, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024 (China); Kang, Litao, E-mail: kangltxy@163.com [Laboratory of Green Energy Materials and Storage Systems, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024 (China); State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences (China); Zhao, Zhe [School of Materials Science & Engineering, Shanghai Institute of Technology, Shanghai 201418 (China)

    2017-03-31

    Highlights: • Mo-doped tungsten bronzes were hydrothermally synthesized at 80 °C. • Samples transformed from hexagonal to monoclinic structure with Mo-content increase. • 1.5% Mo-doped samples show the best near-infrared shielding performance. • High Mo-doping weakens localized surface plasmon resonance (LSPR) absorption and thus NIR shielding performance. • Small polaron absorption seems to be less affected by Mo-doping. - Abstract: Both Mo and W belong to VIB-sub-group, and possess similar ionic radii, electronegativity and oxide lattice configuration. Herein, Mo-doped (0–80 at.%) tungsten bronzes, M{sub x}WO{sub 3}, were hydrothermally prepared to systematically explore the influence of Mo-doping on their micro-structure and optical performance. The products adopted a hexagonal structure within 6 at.% Mo-doping, and transformed into a monoclinic phase with higher Mo-doping content. Further tests suggested that 1.5 at.% Mo-doping is beneficial for the formation of pure hexagonal phase and uniform nano-rod morphology. Optical measures showed that all samples exhibited high and comparable visible transmittance (70–80%), but a very different near infrared (NIR) shielding ability. The sample doped with 1.5 at.% Mo demonstrated the best NIR shielding ability with a transmittance minimum of 20% at 1300 nm. Further increase of Mo-doping dosage remarkably deteriorated NIR shielding ability by depressing the absorption of localized surface plasmon resonance (LSPR). However, the optical absorption from small-polaron was less influenced by the introduction of Mo. As a result, Mo-doping caused an evident blue shift of the infrared absorption peaks from 1350 to 750 nm.

  9. IDENTIFICAÇÃO DE ÁREAS RELEVANTES PARA CONSERVAÇÃO COM BASE EM INDICADORES BIOLÓGICOS: SUBSÍDIO AO ZONEAMENTO DE DOIS PARQUES NACIONAIS NO CERRADO BRASILEIRO

    Directory of Open Access Journals (Sweden)

    Reuber Albuquerque Brandão

    2011-12-01

    Full Text Available A identificação de zonas de manejo de uma unidade de conservação é uma peça-chave para o sucesso de sua gestão. Esse zoneamento, proposto no plano de manejo, baseia-se nos atributos dos ecossistemas inseridos nos limites e entorno da unidade de conservação. No entanto, a proposição de zonas geralmente é um processo mais empírico que técnico. Isso ocorre devido à carência de ferramentas capazes de unir atributos ambientais e valores biológicos dispersos na paisagem. Aqui é apresentada uma ferramenta de análise que identifica regiões de diferentes graus de relevância biológica com base no cruzamento de camadas de informação espacial (declividade, altimetria, classes de vegetação, com um índice denominado Valor de Importância Biológica (VIB produzido pela riqueza e grau de ameaça da fauna em diferentes pontos amostrais. Os registros pontuais de fauna foram obtidos durante uma Avaliação Ecológica Rápida dos Parques Nacionais da Serra da Bodoquena e Chapada dos Guimarães para seu plano de manejo. A importância das diferentes camadas de informação (biológica e espacial foi ponderada utilizando ferramentas de GIS. Este método representou eficientemente as características da paisagem, ajudou a delimitar a zona de amortecimento e indicou a relevância de cada fitofisionomia das Unidades de Conservação na conservação da biodiversidade.

  10. Virtual Prototyping and Validation of Cpps within a New Software Framework

    Directory of Open Access Journals (Sweden)

    Sebastian Neumeyer

    2017-02-01

    Full Text Available As a result of the growing demand for highly customized and individual products, companies need to enable flexible and intelligent manufacturing. Cyber-physical production systems (CPPS will act autonomously in the future in an interlinked production and enable such flexibility. However, German mid-sized plant manufacturers rarely use virtual technologies for design and validation in order to design CPPS. The research project Virtual Commissioning with Smart Hybrid Prototyping (VIB-SHP investigated the usage of virtual technologies for manufacturing systems and CPPS design. Aspects of asynchronous communicating, intelligent- and autonomous-acting production equipment in an immersive validation environment, have been investigated. To enable manufacturing system designers to validate CPPS, a software framework for virtual prototyping has been developed. A mechatronic construction kit for production system design integrates discipline-specific models and manages them in a product lifecycle management (PLM solution. With this construction kit manufacturing designers are able to apply virtual technologies and the validation of communication processes with the help of behavior models. The presented approach resolves the sequential design process for the development of mechanical, electrical, and software elements and ensures the consistency of these models. With the help of a bill of material (BOM- and signal-based alignment of the discipline-specific models in an integrated mechatronic product model, the communication of the design status and changes are improved. The re-use of already-specified and -designed modules enable quick behavior modeling, code evaluation, as well as interaction with the virtualized assembly system in an immersive environment.

  11. Reference binding energies of transition metal carbides by core-level x-ray photoelectron spectroscopy free from Ar+ etching artefacts

    Science.gov (United States)

    Greczynski, G.; Primetzhofer, D.; Hultman, L.

    2018-04-01

    We report x-ray photoelectron spectroscopy (XPS) core level binding energies (BE's) for the widely-applicable groups IVb-VIb transition metal carbides (TMCs) TiC, VC, CrC, ZrC, NbC, MoC, HfC, TaC, and WC. Thin film samples are grown in the same deposition system, by dc magnetron co-sputtering from graphite and respective elemental metal targets in Ar atmosphere. To remove surface contaminations resulting from exposure to air during sample transfer from the growth chamber into the XPS system, layers are either (i) Ar+ ion-etched or (ii) UHV-annealed in situ prior to XPS analyses. High resolution XPS spectra reveal that even gentle etching affects the shape of core level signals, as well as BE values, which are systematically offset by 0.2-0.5 eV towards lower BE. These destructive effects of Ar+ ion etch become more pronounced with increasing the metal atom mass due to an increasing carbon-to-metal sputter yield ratio. Systematic analysis reveals that for each row in the periodic table (3d, 4d, and 5d) C 1s BE increases from left to right indicative of a decreased charge transfer from TM to C atoms, hence bond weakening. Moreover, C 1s BE decreases linearly with increasing carbide/metal melting point ratio. Spectra reported here, acquired from a consistent set of samples in the same instrument, should serve as a reference for true deconvolution of complex XPS cases, including multinary carbides, nitrides, and carbonitrides.

  12. The Molecular Geometric Phase and Light-Induced Conical Intersections

    Science.gov (United States)

    Zak, Emil J.

    2017-06-01

    Potential energy surfaces for electronic states of molecules in strong electromagnetic fields can be described in the dressed-state formalism, which introduces light-induced potentials. A light-induced conical intersection (LICI) [1] appears when two electronic states intersect due to the presence of an external electric field and when the dipole coupling between the field and the molecule vanishes. There are several aspects of quantum dynamics near LICIs, which still require a thorough investigation. How do non-adiabatic effects manifest themselves in polyatomic molecules in strong electromagnetic fields? Are the natural conical-intersections (NCI) and the light-induced conical intersections identical in nature? Do topological effects (Berry phase) [2] influence the nuclear dynamics around NCIs and LICIs? To answer these questions, a computer code for time-propagation of the ro-vibronic wavefunction on multiple coupled potential energy surfaces has been developed. The time-independent zero-order basis is taken from the DUO suite [3], which solves the full ro-vibronic Schrödinger equation for diatomic molecules. Non-adiabatic nuclear dynamics near LICIs will be presented on the examples of NaH and CaF molecules, with a perspective for extension to polyatomics. G. J. Halász, A Vibók, M. Sindelka, N. Moiseyev, L. S. Cederbaum, 2011 J. Phys. B: At. Mol. Opt. Phys. 44 175102 C. Wittig, Phys. Chem. Chem. Phys., 2012, 14, 6409-6432 S. N. Yurchenko, L. Lodi, J. Tennyson, A. V. Stolyarov, Comput. Phys. Commun., 202, 262, 2016

  13. Assessing genetic diversity among Brettanomyces yeasts by DNA fingerprinting and whole-genome sequencing.

    Science.gov (United States)

    Crauwels, Sam; Zhu, Bo; Steensels, Jan; Busschaert, Pieter; De Samblanx, Gorik; Marchal, Kathleen; Willems, Kris A; Verstrepen, Kevin J; Lievens, Bart

    2014-07-01

    Brettanomyces yeasts, with the species Brettanomyces (Dekkera) bruxellensis being the most important one, are generally reported to be spoilage yeasts in the beer and wine industry due to the production of phenolic off flavors. However, B. bruxellensis is also known to be a beneficial contributor in certain fermentation processes, such as the production of certain specialty beers. Nevertheless, despite its economic importance, Brettanomyces yeasts remain poorly understood at the genetic and genomic levels. In this study, the genetic relationship between more than 50 Brettanomyces strains from all presently known species and from several sources was studied using a combination of DNA fingerprinting techniques. This revealed an intriguing correlation between the B. bruxellensis fingerprints and the respective isolation source. To further explore this relationship, we sequenced a (beneficial) beer isolate of B. bruxellensis (VIB X9085; ST05.12/22) and compared its genome sequence with the genome sequences of two wine spoilage strains (AWRI 1499 and CBS 2499). ST05.12/22 was found to be substantially different from both wine strains, especially at the level of single nucleotide polymorphisms (SNPs). In addition, there were major differences in the genome structures between the strains investigated, including the presence of large duplications and deletions. Gene content analysis revealed the presence of 20 genes which were present in both wine strains but absent in the beer strain, including many genes involved in carbon and nitrogen metabolism, and vice versa, no genes that were missing in both AWRI 1499 and CBS 2499 were found in ST05.12/22. Together, this study provides tools to discriminate Brettanomyces strains and provides a first glimpse at the genetic diversity and genome plasticity of B. bruxellensis. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

  14. Changes in Cartilage Morphology of the Knee after 14-days of Bed Rest

    Science.gov (United States)

    Liphardt, A.-M.; Mündermann, A.; Koo, S.; Bäcker, N.; Andriacchi, T.; Zange, J.; Mester, J.; Heer, M.

    Introduction While there are still many unanswered questions related to the effects of space flight and disuse on cartilage health and cartilage morphology the number of in vivo experiments in humans is small For muscle and bone tissue it is well known that unloading results in degeneration of those tissues Also for cartilage previous studies in patients suggest that unloading causes cartilage degeneration Studies using immobilization as a model of unloading help to investigate the importance of experiencing mechanical loads for the maintenance of healthy biological tissues The goal of our study was to investigate whether bed rest induced immobilization has a negative effect on articular cartilage in healthy subjects and if vibration training is a potential counter-measure for these negative effects Methods Eight male healthy subjects 78 1 pm 9 5 kg 179 pm 9 6 cm 26 pm 5 years performed a 14-day bed rest in 6 r -head down tilt HDT The study was designed in a cross-over-design where each subject received a training intervention vib in one phase and no intervention con in the other phase During the training intervention subjects trained 2 x 5-minutes per day at 20 Hz with 2 -- 4 mm amplitude on a vibration plate Galileo 900 Magnet resonance MR imaging of the right knee was performed to measure articular cartilage thickness MR-images 2 mm slice thickness 0 35 mm x 0 35 mm in-plane resolution 448 x 512 pixels were taken before and after bed rest to investigate the effects of bed rest

  15. Product distributions, rate constants, and mechanisms of LiH +H reactions

    Science.gov (United States)

    Defazio, Paolo; Petrongolo, Carlo; Gamallo, Pablo; González, Miguel

    2005-06-01

    We present a quantum-mechanical investigation of the LiH depletion reaction LiH +H→Li+H2 and of the H exchange reaction LiH +H'→LiH'+H. We report product distributions, rate constant, and mechanism of the former, and rate constant and mechanism of the latter reaction. We use the potential-energy surface by Dunne et al. [Chem. Phys. Lett. 336, 1 (2001)], the real-wave-packet method by Gray and Balint-Kurti [J. Chem. Phys. 108, 950 (1998)], and the J-shifting approximation. The H21 nuclear-spin statistics and progressions of vib-rotational states (v',j') rule both initial-state-resolved and thermal product distributions, which have saw-toothed shapes with odd j' preferred with respect to even j'. At high collision energies and temperatures, we obtain a regular 3-to-1 intensity alternation of rotational states. At low collision energies and temperatures, the degeneracy and density of many H2 levels can, however, give more irregular distributions. During the collision, the energy flows from the reactant translational mode to the product vibration and recoil ones. The rate constants of both reactions are not Arrhenius type because the reactions are barrier-less. The low-temperature, LiH depletion rate constant is larger than the H exchange one, whereas the contrary holds at high temperature. The real-time mechanisms show the nuclear rearrangements of the nonreactive channel and of the reactive ones, and point out that the LiH depletion is preferred over the H exchange at short times. This confirms the rate-constant results.

  16. Htr2a gene and 5-HT2A receptor expression in the cerebral cortex studied using genetically modified mice

    Directory of Open Access Journals (Sweden)

    Rodrigo Andrade

    2010-08-01

    Full Text Available Serotonin receptors of the 5-HT2A subtype are robustly expressed in the cerebral cortex where they have been implicated in the pathophysiology and therapeutics of mental disorders and the actions of hallucinogens. Much less is known, however, about the specific cell types expressing 5-HT2A receptors in cortex. In the current study we use immunohistochemical and electrophysiological approaches in genetically modified mice to address the expression of the Htr2a gene and 5-HT2A receptors in cortex. We first use an EGFP expressing BAC transgenic mice and identify three main Htr2A gene expressing neuronal populations in cortex. The largest of these cell populations corresponds to layer V pyramidal cells of the anterior cortex, followed by GABAergic interneurons of the middle layers, and nonpyramidal cells of the subplate/Layer VIb. We then use 5-HT2A receptor knockout mice to identify an antibody capable of localizing 5-HT2A receptors in brain and use it to map these receptors. We find strong laminar expression of 5-HT2A receptors in cortex, especially along a diffuse band overlaying layer Va. This band exhibits a strong anteroposterior gradient that closely matches the localization of Htr2A expressing pyramidal cells of layer V. Finally we use electrophysiological and immunohistochemical approaches to show that most, but not all, GABAergic interneurons of the middle layers are parvalbumin expressing Fast-spiking interneurons and that these cells are depolarized and excited by serotonin, most likely through the activation of 5-HT2A receptors. These results clarify and extend our understanding of the cellular distribution of 5-HT2A receptors in the cerebral cortex.

  17. Determination of bond energies by mass spectrometry. Some transition metal carbonyls

    Energy Technology Data Exchange (ETDEWEB)

    Michels, G.D.

    1979-01-01

    Two groups of transition metal carbonyls have been studied, M(CO)/sub 6/ and M(CO)/sub 5/CS complexes of the Group VIB metals and M/sub 2/(CO)/sub 10/ complexes of the Group VIIB metals. Results for the hexacarbonyl complexes indicate that the measured fragmentation energies are in error by 0.25 +- 0.02 eV per CO produced. This is attributed to excitation of CO to the first vibrational state. Least-squares dissociation energies calculated from corrected data for M(CO)/sub 5/CS complexes indicate that the M--CS bond is 3 to 4 times stronger than the M--CO bonds. Substitution of CS for CO in going from M(CO)/sub 6/ to M(CO)/sub 5/CS weakens the remaining M--CO bonds by an average of 0.2 eV. Previously unreported MnTc(CO)/sub 10/ and TcRe(CO)/sub 10/ are prepared by halide substitution of Tc(CO)/sub 5/Br and Re(CO)/sub 5/Br with Mn(CO)/sub 5//sup -/ and Tc(CO)/sub 5//sup -/, respectively. In the positive ion, metal and mixed-metal decacarbonyls are considered as (CO)/sub 5/M/sup +/--M(CO)/sub 5/ complexes possessing five strong and five weak M--CO bonds. For Mn/sub 2/(CO)/sub 10/ and Re/sub 2/(CO)/sub 10/, M/sup +/--M dissociation energies are 3.0 +- 0.1 and 4.0 +- 0.3 eV, respectively. These energies are 2.5 times greater than those reported for homolytic cleavage to M(CO)/sub 5//sup +/ and M(CO)/sub 5/.

  18. Using the integral equations method to model a 2G racetrack coil with anisotropic critical current dependence

    Science.gov (United States)

    Martins, F. G. R.; Sass, F.; Barusco, P.; Ferreira, A. C.; de Andrade, R., Jr.

    2017-11-01

    Second-generation (2G) superconducting wires have already proved their potential in several applications. These materials have a highly nonlinear behavior that turns an optimized engineering project into a challenge. Between several numerical techniques that can be used to perform this task, the integral equations (IE) method stands out for avoiding mesh problems by representing the 2G wire cross-sectional area by a line. While most applications need to be represented in a 3D geometry, the IE is limited to longitudinal or axisymmetric models. This work demonstrates that a complex 3D geometry can be modeled by several coupled simulations using the IE method. In order to prove this statement, the proposed technique was used to simulate a 2G racetrack coil considering the self-field magnitude (B) and incidence angle (θ) on the tape. The J c characteristic was modeled in terms of parallel and normal to the tape plane magnetic field components (J c(B ∥ , B ⊥)) obtained from a V-I(B, θ) characterization of a tape segment. This result was implemented using commercial software with both A-V (vector magnetic potential and scalar voltage potential) and IE coupled simulations solved by finite elements. This solution bypasses the meshing problem due to the tapes slim geometry, considering each turn a single 1D model, all magnetically interacting in two 2D models. The simulations results are in good agreement to what was both expected and observed in the literature. The simulation is compared to the measured V-I characteristic for a single pancake racetrack coil built with same geometry as its simulation models, and a theoretical study demonstrates the possibilities of the proposed tool for analyzing a racetrack coil current density and electric field behavior in each of its turns.

  19. Fucosylation Deficiency in Mice Leads to Colitis and Adenocarcinoma

    Science.gov (United States)

    Wang, Yiwei; Huang, Dan; Chen, Kai-Yuan; Cui, Min; Wang, Weihuan; Huang, Xiaoran; Awadellah, Amad; Li, Qing; Friedman, Ann; Xin, William W.; Di Martino, Luca; Cominelli, Fabio; Miron, Alex; Chan, Ricky; Fox, James; Xu, Yan; Shen, Xiling; Kalady, Mathew F.; Markowitz, Sanford; Maillard, Ivan; Lowe, John B.; Xin, Wei; Zhou, Lan

    2016-01-01

    Background & Aims De novo synthesis of GDP-fucose, a substrate for fucosylglycans, requires sequential reactions mediated by GDP-mannose 4,6-dehydratase (GMDS) and GDP-4-keto-6-deoxymannose 3,5-epimerase-4-reductase (FX or TSTA3). GMDS deletions and mutations are found in 6%–13% of colorectal cancers; these mostly affect ascending and transverse colon. We investigated whether lack of fucosylation consequent to loss of GDP-fucose synthesis contributes to colon carcinogenesis. Methods FX deficiency and GMDS deletion produce the same biochemical phenotype of GDP-fucose deficiency. We studied a mouse model of fucosylation deficiency (Fx–/– mice) and mice with the full-length Fx gene (controls). Mice were placed on standard chow or fucose-containing diet (equivalent to a control fucosylglycan phenotype). Colon tissues were collected and analyzed histologically or by ELISAs to measure cytokine levels; T cells were also collected and analyzed. Fecal samples were analyzed by 16s rRNA sequencing. Mucosal barrier function was measured by uptake of fluorescent dextran. We transplanted bone marrow cells from Fx–/– or control mice (Ly5.2) into irradiated 8-week old Fx–/– or control mice (Ly5.1). We performed immunohistochemical analyses for expression of Notch and the hes family bHLH transcription factor (HES1) in colon tissues from mice and a panel of 60 human colorectal cancer specimens (27 left-sided, 33 right-sided). Results Fx–/– mice developed colitis and serrated-like lesions. The intestinal pathology of Fx–/– mice was reversed by addition of fucose to the diet, which restored fucosylation via a salvage pathway. In the absence of fucosylation, dysplasia appeared and progressed to adenocarcinoma in up to 40% of mice, affecting mainly the right colon and cecum. Notch was not activated in Fx–/– mice fed standard chow, leading to decreased expression of its target Hes1. Fucosylation deficiency altered the composition of the fecal microbiota, reduced

  20. Modeling collision energy transfer in APCI/CID mass spectra of PAHs using thermal-like post-collision internal energy distributions.

    Science.gov (United States)

    Solano, Eduardo A; Mohamed, Sabria; Mayer, Paul M

    2016-10-28

    The internal energy transferred when projectile molecular ions of naphthalene collide with argon gas atoms was extracted from the APCI-CID (atmospheric-pressure chemical ionization collision-induced dissociation) mass spectra acquired as a function of collision energy. Ion abundances were calculated by microcanonical integration of the differential rate equations using the Rice-Ramsperger-Kassel-Marcus rate constants derived from a UB3LYP/6-311G+(3df,2p)//UB3LYP/6-31G(d) fragmentation mechanism and thermal-like vibrational energy distributions p M E,T char . The mean vibrational energy excess of the ions was characterized by the parameter T char ("characteristic temperature"), determined by fitting the theoretical ion abundances to the experimental breakdown graph (a plot of relative abundances of the ions as a function of kinetic energy) of activated naphthalene ions. According to these results, the APCI ion source produces species below T char = 1457 K, corresponding to 3.26 eV above the vibrational ground state. Subsequent collisions heat the ions up further, giving rise to a sigmoid curve of T char as a function of E com (center-of-mass-frame kinetic energy). The differential internal energy absorption per kinetic energy unit (dE vib /dE com ) changes with E com according to a symmetric bell-shaped function with a maximum at 6.38 ± 0.32 eV (corresponding to 6.51 ± 0.27 eV of vibrational energy excess), and a half-height full width of 6.30 ± 1.15 eV. This function imposes restrictions on the amount of energy that can be transferred by collisions, such that a maximum is reached as kinetic energy is increased. This behavior suggests that the collisional energy transfer exhibits a pronounced increase around some specific value of energy. Finally, the model is tested against the CID mass spectra of anthracene and pyrene ions and the corresponding results are discussed.

  1. a New Equation of State for Solid para-HYDROGEN

    Science.gov (United States)

    Wang, Lecheng; Le Roy, Robert J.; Roy, Pierre-Nicholas

    2015-06-01

    Solid para-H_2 is a popular accommodating host for impurity spectroscopy due to its unique softness and the spherical symmetry of para-H_2 in its J}=0 rotational level. To simulate the properties of impurity-doped solid para-H_2, a reliable model for the `soft' pure solid para-H_2 at different pressures is highly desirable. While a couple of experimental and theoretical studies aimed at elucidating the equation of state (EOS) of solid para-H_2 have been reported, the calculated EOS was shown to be heavily dependent on the potential energy surface (PES) between two para-H_2 that was used in the simulations. The current study also demonstrates that different choices of the parameters governing the Quantum Monte Carlo simulation could produce different EOS curves. To obtain a reliable model for pure solid para-H_2, we used a new 1-D para-H_2 PES reported by Faruk et al. that was obtained by averaging over Hinde's highly accurate 6-D H_2--H_2 PES. The EOS of pure solid para-H_2 was calculated using the PIMC algorithm with periodic boundary conditions (PBC). To precisely determine the equilibrium density of solid para-H_2, both the value of the PIMC time step (τ) and the number of particles in the PBC cell were extrapolated to convergence. The resulting EOS agreed well with experimental observations, and the hcp structured solid para-H_2 was found to be more stable than the fcc one at 4.2K, in agreement with experiment. The vibrational frequency shift of para-H_2 as a function of the density of the pure solid was also calculated, and the value of the shift at the equilibrium density is found to agree well with experiment. T. Momose, H. Honshina, M. Fushitani and H. Katsuki, Vib. Spectrosc. 34, 95(2004). M. E. Fajardo, J. Phys. Chem. A 117, 13504 (2013). I. F. Silvera, Rev. Mod. Phys. 52, 393(1980). F. Operetto and F. Pederiva, Phys. Rev. B 73, 184124(2006). T. Omiyinka and M. Boninsegni, Phys. Rev. B 88, 024112(2013). N. Faruk, M. Schmidt, H. Li, R. J. Le Roy, and P

  2. Optics and Optoelectronics of Two-dimensional Semiconducting Monolayers and Heterostructures

    Science.gov (United States)

    Ross, Jason Solomon

    Until recently, the physics of truly two-dimensional (2D) excitons could only be explored theoretically. Following the discovery of graphene, many 2D materials were quickly identified and isolated, one system being the semiconducting Group VI-B transition metal dichalcogenides (TMDs). These semiconductors are the first air-stable materials that are atomically thin (three atomics thick), and yet can be produced in arbitrarily large lateral sheets. They have a direct band gap in which confinement leads to large spatial overlap of electrons and holes resulting in strongly coupled excitonic transitions that dominate light-matter interactions. The direct band-gap of monolayer TMDs occurs at the corners of the hexagonal Brillouin zone, referred to as the K valleys. Entirely unique to these materials, excitons in adjacent K valleys selectively couple to light of opposite circular polarization, i.e. the K (K') valley is selective to right (left) circularly polarized photons. This property offers the possible realization of novel devices that will manipulate the valley index, known as valleytronics. Further, creating a stacked heterostructure (HS) of two TMD monolayers of different molecular species can exhibit type-II band alignment leading to the first atomically sharp built-in p-n junction and a bright interlayer exciton with long lifetimes. Being flat 2D sheets, it is easy to couple these materials to nearby systems such as microfabricated electrodes and photonic crystal cavities allowing for unique modulation and device schemes. Here, I employ both optical and electronic techniques to study the unique physics of 2D excitons in TMDs as well as demonstrate some of their first optoelectronic and valleytronic devices. The most notable achievement is perhaps the first demonstrations of both atomically thin and 2D heterostructure light emitting diodes and photovoltaic devices. Other breakthroughs include the first demonstration of exciton charging tunability in a 2D system

  3. Polarized matrix infrared spectra of cyclopentadienone: observations, calculations, and assignment for an important intermediate in combustion and biomass pyrolysis.

    Science.gov (United States)

    Ormond, Thomas K; Scheer, Adam M; Nimlos, Mark R; Robichaud, David J; Daily, John W; Stanton, John F; Ellison, G Barney

    2014-01-30

    A detailed vibrational analysis of the infrared spectra of cyclopentadienone (C5H4═O) in rare gas matrices has been carried out. Ab initio coupled-cluster anharmonic force field calculations were used to guide the assignments. Flash pyrolysis of o-phenylene sulfite (C6H4O2SO) was used to provide a molecular beam of C5H4═O entrained in a rare gas carrier. The beam was interrogated with time-of-flight photoionization mass spectrometry (PIMS), confirming the clean, intense production of C5H4═O. Matrix isolation infrared spectroscopy coupled with 355 nm polarized UV for photoorientation and linear dichroism experiments was used to determine the symmetries of the vibrations. Cyclopentadienone has 24 fundamental vibrational modes, Γvib = 9a1 ⊕ 3a2 ⊕ 4b1 ⊕ 8b2. Using vibrational perturbation theory and a deperturbation-diagonalization method, we report assignments of the following fundamental modes (cm(-1)) in a 4 K neon matrix: the a1 modes of X̃ (1)A1 C5H4═O are found to be ν1 = 3107, ν2 = (3100, 3099), ν3 = 1735, ν5 = 1333, ν7 = 952, ν8 = 843, and ν9 = 651; the inferred a2 modes are ν10 = 933, and ν11 = 722; the b1 modes are ν13 = 932, ν14 = 822, and ν15 = 629; the b2 fundamentals are ν17 = 3143, ν18 = (3078, 3076) ν19 = (1601 or 1595), ν20 = 1283, ν21 = 1138, ν22 = 1066, ν23 = 738, and ν24 = 458. The modes ν4 and ν6 were too weak to be detected, ν12 is dipole-forbidden and its position cannot be inferred from combination and overtone bands, and ν16 is below our detection range (calculations, assigned as two quantum transitions, and used to assign some of the weak and infrared inactive fundamental vibrations.

  4. Micro-Raman spectroscopy a powerful technique to identify crocidolite and erionite fibers in tissue sections

    Science.gov (United States)

    Rinaudo, C.; Croce, A.; Allegrina, M.; Baris, I. Y.; Dogan, A.; Powers, A.; Rivera, Z.; Bertino, P.; Yang, H.; Gaudino, G.; Carbone, M.

    2013-05-01

    .I. Baris, P. Bertino, B. Brass, S. Comertpay, A.U. Dogan et al. Proc. Nat. Acad. Sci U S A 2011;108 (33), 13618. A.U. Dogan, Y.I.Baris, M. Dogan, S. Emri, I. Steele, A.G. Elmishad et al. Cancer Res. 2006,66 (10), 5063. M. Dogan. Scanning. 2012, 34 (1), 37. C. Rinaudo, M. Allegrina, E. Fornero, M. Musa, A. Croce, D. Bellis. J. Raman Spectrosc. 2010, 41 (1), 27. C. Rinaudo, A. Croce, M. Musa, E. Fornero, M. Allegrina, P. Trivero, et al. Appl. Spectrosc. 2010, 64 (6), 571. M. Musa, A. Croce, M. Allegrina, C. Rinaudo, E. Belluso, D. Bellis, et al. Vib. Spectrosc. 2012, 61, 66.

  5. Evaluation of Slaughtered lambs Results from Varamini Ewes Crossing with Shal, Afshar, Moghani and Varamini Rams

    Directory of Open Access Journals (Sweden)

    reza seyedsharifi

    2016-08-01

    not significant. Finally, male had more significantly cross surface than female. Average percentage for lion, thigh, flank, brisket, neck, longissmus muscle area and carcass length, full and empty digestive system in different genetic group has no significant difference, also, average for, shoulder, legs, tail, heat, lean percentage and bone in 10-12 vibs sample and skin and fat percentage in this sample was significantly different in various groups. Sex effect on total removable fat and percentage of various carcass sections expect of thigh, lion and neck percentages, other carcass sections have significant differences in two finishing periods.

  6. 210-Pb Study of Fjord Sedimentation Rates in the South Shetland Islands and Antarctic Peninsula

    Science.gov (United States)

    Kimball, B. L.; Nittrouer, C. A.; Landowski, C. M.; Koppes, M.; Hallet, B.

    2007-12-01

    As part of a study concerning the factors controlling rates of glacial erosion and sedimentation across climatic regimes, sixteen kasten cores were collected from ten fjords in the South Shetland Islands and Antarctic Peninsula in April and May, 2007 from the R/VIB Nathaniel B. Palmer. They were sampled for 210Pb measurements of accumulation rates and associated sedimentological observations (x-radiography, sedimentology). The cores were collected from basins within a few kilometers of the calving front at the respective glacier, where sediment accumulation was observed in 3.5 kHz sub-bottom profiles. Core lengths ranged from 34-289 cm; in 7 of the 16 core locations, multiple deployments were required to retrieve even a short sediment core due to the hardness of the bed. For most of the cores (10 of 16) sandy mud has accumulated steadily at rates ranging from 1 to 10 mm/y over the past century, as tightly defined by clear linear trends of 10 to 15 log 210Pb values versus depth, with r2 ranging from 0.75-0.98. The rates of accumulation appear to be independent of distance from the calving front, and most likely reflect variability in glacial-marine sediment delivery to, and basin morphology of, individual fjords. Several cores show evidence of variable sedimentation with pulses of sand emplacement. Three cores contained a surficial layer >50 cm thick of uniform 210Pb activity, indicating recent, rapid deposition of a large turbidity current or mass flow. The consistency of many of the 210Pb profiles implies that, over the past century, the glacial-marine processes that supplied, transported and deposited sediment in these sub-polar and polar fjords have not varied markedly. This contrasts with other glacial-marine systems in warmer regions such SE Alaska, where sedimentation in the fjords from calving temperate glaciers tends to vary significantly, and where the accumulation tends to slow as the calving front recedes rapidly from the core location. The rates of

  7. Effect of tendon vibration during wide-pulse neuromuscular electrical stimulation (NMES) on muscle force production in people with spinal cord injury (SCI).

    Science.gov (United States)

    Bochkezanian, Vanesa; Newton, Robert U; Trajano, Gabriel S; Vieira, Amilton; Pulverenti, Timothy S; Blazevich, Anthony J

    2018-02-13

    Neuromuscular electrical stimulation (NMES) is commonly used in skeletal muscles in people with spinal cord injury (SCI) with the aim of increasing muscle recruitment and thus muscle force production. NMES has been conventionally used in clinical practice as functional electrical stimulation (FES), using low levels of evoked force that cannot optimally stimulate muscular strength and mass improvements, and thus trigger musculoskeletal changes in paralysed muscles. The use of high intensity intermittent NMES training using wide-pulse width and moderate-intensity as a strength training tool could be a promising method to increase muscle force production in people with SCI. However, this type of protocol has not been clinically adopted because it may generate rapid muscle fatigue and thus prevent the performance of repeated high-intensity muscular contractions in paralysed muscles. Moreover, superimposing patellar tendon vibration onto the wide-pulse width NMES has been shown to elicit further increases in impulse or, at least, reduce the rate of fatigue in repeated contractions in able-bodied populations, but there is a lack of evidence to support this argument in people with SCI. Nine people with SCI received two NMES protocols with and without superimposing patellar tendon vibration on different days (i.e. STIM and STIM+vib), which consisted of repeated 30 Hz trains of 58 wide-pulse width (1000 μs) symmetric biphasic pulses (0.033-s inter-pulse interval; 2 s stimulation train; 2-s inter-train interval) being delivered to the dominant quadriceps femoris. Starting torque was 20% of maximal doublet-twitch torque and stimulations continued until torque declined to 50% of the starting torque. Total knee extensor impulse was calculated as the primary outcome variable. Total knee extensor impulse increased in four subjects when patellar tendon vibration was imposed (59.2 ± 15.8%) but decreased in five subjects (- 31.3 ± 25.7%). However, there were no

  8. Infiltração de água no solo em um latossolo vermelho da região sudoeste dos cerrados com diferentes sistemas de uso e manejo Water infiltration into an oxisol in the south-west cerrado region under different use and management systems

    Directory of Open Access Journals (Sweden)

    José Antonio Maior Bono

    2012-12-01

    Full Text Available Na região do Cerrado, as atividades agrícolas têm provocado impactos negativos, principalmente, na qualidade do solo e da água. Tanto em sistemas de exploração agrícola ou de pecuária, com diferentes manejos, a degradação física do solo é uma das consequências da redução da produtividade. O objetivo deste trabalho foi verificar a infiltração de água no solo sob influência de diferentes sistemas de manejo em um Latossolo Vermelho distrófico na região dos Cerrados. Os tratamentos foram os seguintes sistemas de manejo: a solo sob vegetação nativa; b solo com implantação de lavoura de soja durante um ano, seguido de três anos de pastagens; c solo com implantação de lavoura de soja durante quatro anos, seguidos por quatro anos de pastagem; d solo com lavoura de soja contínua em sistema de plantio direto; e e solo com pastagem continuamente. Foram avaliadas, no período de 1995 a 2002, a velocidade de infiltração básica (VIB e a infiltração de água acumulada no solo, utilizando o método de duplos anéis concêntricos. Os usos do solo com sistema de lavoura contínua, pecuária contínua e integração lavoura-pecuária tiveram a velocidade de infiltração básica e infiltração acumulada reduzidas em relação ao solo com vegetação nativa na região do Cerrado. Entre os sistemas estudados, o sistema de integração lavoura-pecuária foi o que apresentou valores mais próximos aos do solo sob vegetação nativa.In the Cerrado region, agricultural activities have caused negative impacts mainly on the soil and water quality. Both in crop and livestock systems, with different managements, the soil physical degradation has led to reduced productivity. The objective of this study was to investigate water infiltration into a Dystrophic Red Latosol of the Cerrado region under different managements. The treatments consisted of the management systems: a soil under native vegetation, b soil with soybean for one year

  9. Core-level spectra and binding energies of transition metal nitrides by non-destructive x-ray photoelectron spectroscopy through capping layers

    Science.gov (United States)

    Greczynski, G.; Primetzhofer, D.; Lu, J.; Hultman, L.

    2017-02-01

    We present the first measurements of x-ray photoelectron spectroscopy (XPS) core level binding energies (BE:s) for the widely-applicable group IVb-VIb polycrystalline transition metal nitrides (TMN's) TiN, VN, CrN, ZrN, NbN, MoN, HfN, TaN, and WN as well as AlN and SiN, which are common components in the TMN-based alloy systems. Nitride thin film samples were grown at 400 °C by reactive dc magnetron sputtering from elemental targets in Ar/N2 atmosphere. For XPS measurements, layers are either (i) Ar+ ion-etched to remove surface oxides resulting from the air exposure during sample transfer from the growth chamber into the XPS system, or (ii) in situ capped with a few nm thick Cr or W overlayers in the deposition system prior to air-exposure and loading into the XPS instrument. Film elemental composition and phase content is thoroughly characterized with time-of-flight elastic recoil detection analysis (ToF-E ERDA), Rutherford backscattering spectrometry (RBS), and x-ray diffraction. High energy resolution core level XPS spectra acquired with monochromatic Al Kα radiation on the ISO-calibrated instrument reveal that even mild etching conditions result in the formation of a nitrogen-deficient surface layer that substantially affects the extracted binding energy values. These spectra-modifying effects of Ar+ ion bombardment increase with increasing the metal atom mass due to an increasing nitrogen-to-metal sputter yield ratio. The superior quality of the XPS spectra obtained in a non-destructive way from capped TMN films is evident from that numerous metal peaks, including Ti 2p, V 2p, Zr 3d, and Hf 4f, exhibit pronounced satellite features, in agreement with previously published spectra from layers grown and analyzed in situ. In addition, the N/metal concentration ratios are found to be 25-90% higher than those obtained from the corresponding ion-etched surfaces, and in most cases agree very well with the RBS and ToF-E ERDA values. The N 1 s BE:s extracted from

  10. Fast infrared spectroscopy in supercritical fluids

    International Nuclear Information System (INIS)

    Sun, X.

    2000-05-01

    Chapter 1: Introduction. A brief introduction to supercritical fluids is given, illustrating why supercritical fluids are unique solvents and why there is a wide application of supercritical fluids in industry and laboratories. Potential ways for solvation in supercritical fluids to affect reactivity are briefly reviewed. A general introduction to the photochemistry of organometallic complexes is also given. Chapter 2: Time resolved vibrational spectroscopy. Time resolved resonance Raman is introduced and compared with Time-resolved infrared spectroscopy (TRIR). The different approaches of TRIR, including microsecond, nanosecond, and ultrafast (picosecond and femtosecond) systems are discussed. The advantages and disadvantages of these systems are also compared. The TRIR apparatus using an IR diode laser used for work in this thesis are described in detail. Experimental procedures for supercritical fluid TRIR experiments are described with emphasis on handling the IR cell for supercritical fluids and preparation of supercritical fluid solutions. Chapter 3: Photochemistry of group VIB hexacarbonyl compounds in supercritical noble gases and CO 2 solutions. A systematic TRIR study of the photolysis of M(CO) 6 in supercritical Ar, Kr, Xe, and CO 2 and the observation of M(CO) 5 L (M = Cr, Mo, and W; L = Ar (W only), Kr, Xe, and CO 2 ) is described. The second-order rate constants for the reaction of M(CO) 5 L with CO have been evaluated and the reactivity for each metal is Kr > Xe ∼ CO 2 . For M(CO) 5 Kr, M(CO) 5 Xe, or M(CO) 5 (CO 2 ), the reactivity is Cr ∼ Mo > W. In supercritical Kr doped with either Xe or CO 2 , the M(CO) 5 moiety interacts with Xe or CO 2 in preference to Kr. The effect of solvent density on the rate of the reaction of W(CO) 5 (CO 2 ) with CO has been investigated. The reaction of W(CO) 5 (CO 2 ) with CO in scCO 2 is predominantly a dissociative process. The activation energies for the reaction of W(CO) 5 Xe and W(CO) 5 (CO 2 ) with CO and

  11. Perdas de solo e água em plantio de Acacia mangium wild e savana em Roraima, norte da Amazônia Soil and water losses in Acacia mangium wild plantations and natural savanna in Roraima, northern Amazon

    Directory of Open Access Journals (Sweden)

    Luciana da Silva Barros

    2009-04-01

    Full Text Available Plantios florestais de Acacia mangium constituem uma alternativa cada vez mais adotada em áreas de savanas do norte da Amazônia (Roraima e podem causar alterações significativas de características do solo. Neste sentido, o objetivo deste estudo foi determinar perdas de solo e de água por erosão, que ocorrem em escoamento superficial (run off em savana nativa e plantios de acácia na região Amazônica. Para isso, foram instaladas em duas fazendas, Santa Rita e Araçá, localizadas no município de Bonfim, na região da Serra da Lua, calhas coletoras de sedimentos, acopladas a caixas d'água, em Argissolo Vermelho-Amarelo. Foram determinadas a granulometria, a densidade aparente (Dap, a resistência à penetração (RP e a velocidade de infiltração (VIB, bem como parâmetros físicos relacionados a perdas de solo. O delineamento experimental utilizado foi o de blocos ao acaso, com três tratamentos: cobertura natural de savana (SV, plantio de Acacia mangium com um ano de idade (P1 e plantio de Acacia mangium com quatro anos de idade (P4, em três repetições. O experimento teve a duração de 12 meses (setembro de 2006 a agosto de 2007. Os resultados indicaram maiores perdas de solo e de água no plantio mais recente de acácia (P1, de savana nativa e do plantio com 4 anos (P4. Os resultados foram atribuídos à exposição do solo no período inicial de desenvolvimento da planta, ao selamento superficial e à coesão do solo. O pico de perdas de solo ocorreu nos meses de abril a agosto, sendo o tipo de cobertura vegetal o fator determinante para redução das perdas de solo e de água por erosão, sendo que as práticas de plantio no sentido do declive provavelmente agravaram as perdas de solo nos plantios de Acácia. Neste trabalho, a densidade do solo e o teor de matéria orgânica não representaram bons indicadores do tipo de manejo adotado na área.As an alternative land use of savanna areas in Roraima, commercial forest stands of