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Sample records for tang niao ning

  1. Effects of Tang Niao Ning decoction on ET-1, GMP-140 and TXB2 in diabetic rats

    International Nuclear Information System (INIS)

    Song Jumin; Wang Lifen; Liao Han; Wang Wei; Hua Weiguo

    2003-01-01

    To investigate the effects of Tang Niao Ning decoction on fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG), endothelin (ET-1), platelet granule membrane protein (GMP-140), thromboxane B 2 (TXB 2 ), 6-keto-prostaglandin F 1α (6-keto-PGF 1α ), the selected female Wistar rats were modeled by streptozotocin (STZ) and high fat diets, and were randomly divided into two groups as Tang Niao Ning and model group, while the normal control group was set up. The Tang Niao Ning group started to supply decoctions after these rats had been fed one week with high fat diets. The rats were killed after six weeks. Above items were examed. The results showed that the model group displayed marked difference when the experiment finished compared with the normal group. The contents of fasting blood glucose and blood lipid were increased, accompanied with the phenomena of hoisting ET-1, enhancing GMP-140, increasing TXB 2 and droping 6-Keto-PGF 1α . After treatment in time with Tang Niao Ning decoction, all kinds of items were adjusted to normal level gradually. It suggested that the treatment with Tang Niao Ning decoction might decrease FBG and blood lipid. In some ways, the decoction could improve the signs of blood stasis. The regulation mechanisms of the decoction was characteristic of wholism through many channels

  2. Tang-Luo-Ning Improves Mitochondrial Antioxidase Activity in Dorsal Root Ganglia of Diabetic Rats: A Proteomics Study

    Directory of Open Access Journals (Sweden)

    Taojing Zhang

    2017-01-01

    Full Text Available Tang-luo-ning (TLN is a traditional Chinese herbal recipe for treating diabetic peripheral neuropathy (DPN. In this study, we investigated mitochondrial protein profiles in a diabetic rat model and explored the potential protective effect of TLN. Diabetic rats were established by injection of streptozocin (STZ and divided into model, alpha lipoic acid (ALA, and TLN groups. Mitochondrial proteins were isolated from dorsal root ganglia and proteomic analysis was used to quantify the differentially expressed proteins. Tang-luo-ning mitigated STZ-induced diabetic symptoms and blood glucose level, including response time to cold or hot stimulation and nerve conductive velocity. As compared to the normal, there were 388 differentially expressed proteins in the TLN group, 445 in ALA group, and 451 in model group. As compared to the model group, there were 275 differential proteins in TLN group and 251 in ALA group. As compared to model group, mitochondrial complex III was significantly decreased, while glutathione peroxidase and peroxidase were increased in TLN group. When compared with ALA group, the mitochondrial complex III was increased, and mitochondrial complex IV was decreased in TLN group. Together, TLN should have a strong antioxidative activity, which appears to be modulated through regulation of respiratory complexes and antioxidases.

  3. Tang-Luo-Ning, a Traditional Chinese Medicine, Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis of Schwann Cells under High Glucose Environment

    Directory of Open Access Journals (Sweden)

    Weijie Yao

    2017-01-01

    Full Text Available Tang-Luo-Ning (TLN has a definite effect in the clinical treatment of diabetic peripheral neuropathy (DPN. Schwann cells (SCs apoptosis induced by endoplasmic reticulum stress (ER stress is one of the main pathogeneses of DPN. This study investigates whether TLN can inhibit SCs apoptosis by inhibiting ER stress-induced apoptosis. Our previous researches have demonstrated that TLN could increase the expression of ER stress marker protein GRP78 and inhibited the expression of apoptosis marker protein CHOP in ER stress. In this study, the results showed that TLN attenuated apoptosis by decreasing Ca2+ level in SCs and maintaining ER morphology. TLN could decrease downstream proteins of CHOP including GADD34 and Ero1α, while it increased P-eIF2α and decreased the upstream proteins of CHOP including P-IRE1α/IRE1α and XBP-1, thereby reducing ER stress-induced apoptosis.

  4. Er tang fremtidens superfood?

    DEFF Research Database (Denmark)

    Holdt, Susan Løvstad

    seneste år fået øjnene op for tang indenfor områderne: biokemikalier og bioaktive stoffer, ekstraktion, gastronomi, produktudvikling, foder, bioraffinaderier, dyrkning osv. Men hvad er det tang kan? Dette foredrag vil vise at vi med tangdyrkning kan rykke mere bæredygtig fødevareproduktion ud på havet...

  5. X Q TANG

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. X Q TANG. Articles written in Bulletin of Materials Science. Volume 41 Issue 2 April 2018 pp 51. Effect of oxygen vacancies on Li-storage of anatase TiO 2 (001) facets: a first principles study · H CHEN Y H DING X Q TANG W ZHANG J R YIN P ZHANG Y JIANG · More Details ...

  6. Tang med omtanke

    DEFF Research Database (Denmark)

    Schlundt, Jørgen

    2013-01-01

    Befolkningen bør kende både mulige positive og negative effekter af fødevarer, før de spiser dem. Det mener Jørgen Schlundt, DTU Fødevareinstituttet, med henvisning til Ole G. Mouritsens kritik af instituttets udmeldinger om tang i det seneste nummer af Aktuel Naturvidenskab.......Befolkningen bør kende både mulige positive og negative effekter af fødevarer, før de spiser dem. Det mener Jørgen Schlundt, DTU Fødevareinstituttet, med henvisning til Ole G. Mouritsens kritik af instituttets udmeldinger om tang i det seneste nummer af Aktuel Naturvidenskab....

  7. Greg Tang: Making Math Count

    Science.gov (United States)

    Pierpont, Katherine

    2006-01-01

    Greg Tang has a resume that could get his foot in the door to a lot of places. A graduate of Harvard with both a B.A. and M.A. in economics, Tang has found success as a business executive, a speechwriter, a software designer and owner of a Tae Kwon Do school. After the publication of his first best-selling book for children, "The Grapes of Math"…

  8. Belöning och motivation

    OpenAIRE

    Blomqvist, Johnny

    2015-01-01

    Många företag använder sig av belöningssystem för att hålla kvar den nuvarande personalen och för att motivera personalen till ett bättre resultat i framtiden. För att ett belöningssystem skall fungera måste personalen vara motiverade. Syftet med detta arbete är att utreda vad personalen i några företag på Kimitoön anser om belöning och betydelsen av belöning i arbetet. I undersökningen utreder jag även motivationens betydelse i arbetet och vilken typ av belöning som motiverar på längre si...

  9. Hoia ja keela / Mati Tang, Anne Oolup

    Index Scriptorium Estoniae

    Tang, Mati

    2006-01-01

    AS Tallinna Lennujaama plaan pikendada Kuressaare lennujaama lennurada elamukvartali suunas on leidnud vastuseisu maandumiskoridori alla jääva Marientali linnaosa elanikes. Arvamust avaldavad Kuressaare lennujaama juhataja M. Tang ja Kuressaare elanik A. Oolup

  10. Riikide majandusvabaduse hindamise metoodikad ning majandusvabadus Eestis / Mario Lambing

    Index Scriptorium Estoniae

    Lambing, Mario

    2005-01-01

    Heritage Foundationi ja The Wall Street Journali uuringust "Majandusvabaduse indeks" ning Fraseri instituudi poolt koostatavast raportist "Majandusvabadus maailmas". Tabelid: Majandusvabaduse indeksite kajastatavad valdkonnad ning nende väärtused Eestis; Majandusvabaduse edetabelid. Graafik: Eesti hinne ja koht majandusvabaduse indeksites

  11. Grandfather Tang Goes to High School

    Science.gov (United States)

    Johnson, Iris DeLoach

    2006-01-01

    This article describes how the children's literature book, Grandfather Tang's Story, which is commonly used in the elementary grades, may be used at the high school level to engage students in an exploration of area and perimeter which includes basic operations with square roots, ordering numbers (decimal approximations, and their exact…

  12. Effects of Lizhong Tang on gastrointestinal motility in mice.

    Science.gov (United States)

    Lee, Min Cheol; Ha, Wooram; Park, Jinhyeong; Kim, Junghoon; Jung, Yunjin; Kim, Byung Joo

    2016-09-14

    To investigate the effects of Lizhong Tang, a traditional Chinese medicine formula, on gastrointestinal motility in mice. The in vivo effects of Lizhong Tang on GI motility were investigated by measuring the intestinal transit rates (ITRs) and gastric emptying (GE) values in normal mice and in mice with experimentally induced GI motility dysfunction (GMD). In normal ICR mice, the ITR and GE values were significantly and dose-dependently increased by Lizhong Tang (ITR values: 54.4% ± 1.9% vs 65.2% ± 1.8%, P Tang and 54.4% ± 1.9% vs 83.8% ± 1.9%, P Tang; GE values: 60.7% ± 1.9% vs 66.8% ± 2.1%, P Tang and 60.7% ± 1.9% vs 72.5% ± 1.7%, P Tang). The ITRs of the GMD mice were significantly reduced compared with those of the normal mice, which were significantly and dose-dependently reversed by Lizhong Tang. Additionally, in loperamide- and cisplatin-induced models of GE delay, Lizhong Tang administration reversed the GE deficits. These results suggest that Lizhong Tang may be a novel candidate for development as a prokinetic treatment for the GI tract.

  13. Educators Eye Ning Transition to a Pay Model

    Science.gov (United States)

    Davis, Michelle R.

    2010-01-01

    The author reports on a move by the online social-networking site Ning to start charging for its services which has raised worries that new fees could stifle educators' technological collaboration and creativity and touch off similar moves by other companies that provide comparable services heavily used by educators. Ning, which provides a…

  14. Eight new species of Cycloneuroterus Melika & Tang gallwasps from Taiwan and mainland China (Hymenoptera: Cynipidae: Cynipini).

    Science.gov (United States)

    Tang, Chang-Ti; Sinclair, Frazer; Hearn, Jack; Yang, Man-Miao; Stone, Graham N; Nicholls, James A; Schwéger, Szabina; Melika, George

    2016-03-11

    Eight new species of cynipid gallwasps, Cycloneuroterus abei Melika & Tang, C. ergei Tang & Melika, C. gilvus Melika & Tang, C. globosus Melika & Tang, C. jianwui Tang & Melika, C. lohsei Melika & Tang, C. tumiclavus Tang & Melika, C. uraianus Tang & Melika, from Taiwan and mainland China are described. Descriptions, diagnoses, biology, and host associations for the new species and a key to all Cycloneuroterus species are given. All taxa are supported by morphological and molecular data. Seven newly described species induce galls on Quercus subgenus Cyclobalanopsis, while one, C. uraianus, induces galls on Castanopsis. This is the first Cycloneuroterus species known to associate with Castanopsis.

  15. Tool Measures Depths of Defects on a Case Tang Joint

    Science.gov (United States)

    Ream, M. Bryan; Montgomery, Ronald B.; Mecham, Brent A.; Keirstead, Bums W.

    2005-01-01

    A special-purpose tool has been developed for measuring the depths of defects on an O-ring seal surface. The surface lies in a specially shaped ringlike fitting, called a capture feature tang, located on an end of a cylindrical segment of a case that contains a solid-fuel booster rocket motor for launching a space shuttle. The capture feature tang is a part of a tang-and-clevis, O-ring joint between the case segment and a similar, adjacent cylindrical case segment. When the segments are joined, the tang makes an interference fit with the clevis and squeezes the O-ring at the side of the gap.

  16. Tang Xianzu and Shakespeare: Cultural Giants of East and West

    Institute of Scientific and Technical Information of China (English)

    Zou; Yuanjiang

    2016-01-01

    In the early years of the last century,Aoki Masaru,a Japanese drama history expert,for the first time compared Tang Xianzu and William Shakespeare from an international perspective.Tang was born in 1550,14years before Shakespeare,but they died in the same year,1616.Masaru notes in his History of Chinese Modern Drama:'They both were drama giants,born in the same historical period.

  17. Distsiplinaarsest, aporeetilisest ning mittedistsiplinaarsest mõtlemisest / Airi Liimets

    Index Scriptorium Estoniae

    Liimets, Airi, 1959-

    2009-01-01

    Lähtudes Michel Foucault’ mõtetest diskursuse, kõnelevate häälte, filosoofia ja selle alguse kohta, küsib autor, missugusel viisil oleks võimalik mõelda muusikast ja muusikapedagoogikast, ja toob esile kolm mõtlemisviisi ning vaatleb neid teaduse vaatepunktist rõhuasetusega muusikapedagoogikal ja muusikal

  18. Leipzigi kirjandusauhind: "Sõda ja rahu" ning filosoofia ja perverssused

    Index Scriptorium Estoniae

    2011-01-01

    Leipzigi kirjandusmessi auhinna ilukirjanduse kategoorias sai austerlane Clemens J. Setz jutukogu "Die Lieber zur Zeit des Mahlstädter Kindes" ("Armastus Mahlstadti lapse ajal"). Tõlkeauhinna sai Barbara Conradi uue L. Tolstoi "Sõja ja rahu" tõlke eest ning aimekirjanduse ja esseistikaauhind läks Frankfurter Allgemeine Zeitungi vastutavale toimetajale Henning Ritterile

  19. Balti kalleim lao- ning tootmispindade rent on Riias / Kristo Kiviorg

    Index Scriptorium Estoniae

    Kiviorg, Kristo

    2005-01-01

    Ilmunud ka: Delovõje Vedomosti 21. sept. lk. 12. Tootmis- ja laopindade rent Baltimaades ja Soomes. Vt. samas: Tallinnas lao- ning tootmispinnad poolaastaga kallinenud kuni 37%; Helsingis on kõige rohkem tõusnud C-kvaliteediklassi pinnad; Tartu piirkonnas enamik saadaolevaid pindu keskmises või halvas seisukorras

  20. Gaasitoru, ujuv saun ning helisevad tuutud / Karin Paulus

    Index Scriptorium Estoniae

    Paulus, Karin, 1975-

    2008-01-01

    Veneetsia XI arhitektuuribiennaalile kandideerinud tööde tutvustus. Biennaali teemaks on "Majade taga. Arhitektuur väljaspool ehitisi". Eestit esindab projekt "Gaasitoru", autorid Maarja Kask ja Ralf Lõoke arhitektuuribüroost Salto ning skulptor Neeme Külm. Teise koha said Eve Kask, Signe Kivi ja Andrus Kõresaar tööga "Peatus". Kolmas koht läks Villem Tomiste projektile "Veealune Veneetsia"

  1. En EU-strategi for integreret hjemmetræning

    DEFF Research Database (Denmark)

    Larsen, Torben

    i 3 forskellige EU-lande, 4) Pilotforsøg med TeleRehab som supplement til den direkte hjemmetræning og 5) Sammenfatning af evidensgrundlaget i en MTV efter den danske 4-grenede model.    Baseret på en SWOT-analyse satses der på implementering af forsøgsresultaterne via en meso-strategi, hvor et...

  2. Farris-Tang retractor in optic nerve sheath decompression surgery.

    Science.gov (United States)

    Spiegel, Jennifer A; Sokol, Jason A; Whittaker, Thomas J; Bernard, Benjamin; Farris, Bradley K

    2016-01-01

    Our purpose is to introduce the use of the Farris-Tang retractor in optic nerve sheath decompression surgery. The procedure of optic nerve sheath fenestration was reviewed at our tertiary care teaching hospital, including the use of the Farris-Tang retractor. Pseudotumor cerebri is a syndrome of increased intracranial pressure without a clear cause. Surgical treatment can be effective in cases in which medical therapy has failed and disc swelling with visual field loss progresses. Optic nerve sheath decompression surgery (ONDS) involves cutting slits or windows in the optic nerve sheath to allow cerebrospinal fluid to escape, reducing the pressure around the optic nerve. We introduce the Farris-Tang retractor, a retractor that allows for excellent visualization of the optic nerve sheath during this surgery, facilitating the fenestration of the sheath and visualization of the subsequent cerebrospinal fluid egress. Utilizing a medial conjunctival approach, the Farris-Tang retractor allows for easy retraction of the medial orbital tissue and reduces the incidence of orbital fat protrusion through Tenon's capsule. The Farris-Tang retractor allows safe, easy, and effective access to the optic nerve with good visualization in optic nerve sheath decompression surgery. This, in turn, allows for greater surgical efficiency and positive patient outcomes.

  3. Thermoluminescence authentication of T'ang and Han Dynasty pottery

    International Nuclear Information System (INIS)

    Price, D.M.

    1997-01-01

    More than 80 pieces of T'ang Dynasty and 40 Han Dynasty style ceramic wares have been analysed to determine the amount of thermoluminescence (TL) accumulated since the initial firing of the object and the level of the radiation flux which has created the TL. This paper presents a summary of the thermoluminescence analysis results. Approximately 60% of Han ceramics and 45% of the T'ang pottery authenticated have been shown to belong to periods other than that stylistically suggested. Items which have been found not to be of the anticipated antiquity generally fall into distinct age groups. Of the T'ang wares the most commonly copied item is found to be the horse and for the Han pieces, human figures and ewers/pots/vases represent the most frequently reproduced wares

  4. Lapse koolivalmidus liit- ning ühevanuste rühmas / Lee Kerde

    Index Scriptorium Estoniae

    Kerde, Lee

    2008-01-01

    2006/2007. õppeaastal Tallinna viies lasteaias tehtud uuringust, et selgitada lapsevanemate ning lasteaiaõpetajate suhtumist koolivalmiduse saavutamise ühevanuste ja liitrühmas ning testida laste vaimset koolivalmidust

  5. SOCIAL NETWORKING IN PHYSICAL EDUCATION: Undergraduate Students’ Views on Ning

    Directory of Open Access Journals (Sweden)

    Gülfem SEZEN BALCIKANLI

    2012-04-01

    Full Text Available It was the aim of this study to investigate physical education undergraduate students’ views on the use of social networking, one of the most typical representations of Web 2.0 technologies. In order to do so, the researcher, who was the instructor of the class, entitled “Fair Play Education in Sport”, introduced Ning and its educational aspects to her students with a 50-minute presentation prior to the study. Following this, the students were encouraged to use this networking for 15 weeks in parallel with their class. During this application, the researcher helped the students to make the best use of Ning in educational settings. Upon the implementation, the researcher interviewed the students (n=19 in five groups on the basis of the questions prepared and piloted earlier. The interviews demonstrated that the students enjoyed using social networking in educational settings. The findings of the study were the following: Increasing student-student and teacher-student interaction, enhancing student motivation and classroom climate, sharing materials with the instructor and students, making use of students’ interests and needs, and making learning process more interesting and permanent. The research concluded that social networking could be used in PE classes effectively.

  6. Protective effect of Ssanghwa-tang fermented by Lactobacillus ...

    African Journals Online (AJOL)

    Ssanghwa-tang (SHT) is a traditional herbal medicine formula that has been used for the development of physical strength, relief of pain, and the reduction of fatigue. In this study, we fermented SHT with Lactobacillus fermentum (L. fermentum), Lactobacillus gasseri (L.gasseri), or Lactobacillus casei (L.casei) to investigate ...

  7. An experimental study in treatment for endometriosis with Xiao Chaihu Tang in rats

    International Nuclear Information System (INIS)

    Pan Li; Zheng Hui

    2006-01-01

    To explore the mechanism of Xiao Chaihu Tang in the treatment for endometriosis in rats,the rat model of endometriosis was established and were treated with Xiao Chaihu Tang , Danazol and Xiao Chaihu Tang plus Danazol for 4 weeks, respectively. Cyclooxygenase-2(COX- 2) expression in each group of endometrium and endometriotic tissue was observed by immuno- histochemistry method. The results showed that the expression of COX-2 in the endometriotic tissue was lower than that in endometrium in Xiao Chaihu Tang group and Xiao Chaihu Tang plus Danazol group, while Danazol group and control group were the opposite to Xiao Chaihu Tang group. The mechanism of Xiao Chaihu Tang in the treatment for endometriosis may be to decrease the COX-2 expression and reduce the formation of prostaglandins. (authors)

  8. Effekten av styrketräning kan begränsas mer av samtidig högintensiv intermittent aerob träning än av lågintensiv kontinuerlig aerob träning

    OpenAIRE

    Jutman, Magnus

    2012-01-01

    Introduktion Utifrån tidigare forskning har en modell föreslagits som beskriver att lågintensiv aerob uthållighetsträning ska ha mindre negativ påverkan på effekten av styrketräning jämfört med högintensiv aerob uthållighetsträning. Detta påstående har funnit visst stöd i litteraturen men vidare forskning krävs för att det ska kunna fastställas. Syfte Denna studie syftar till att undersöka ifall det föreligger någon skillnad mellan högintensiv aerob intermittent löpträning och lågintensiv aer...

  9. Sattumuslikkus, hegemoonia ning õiglus: John Rawls ja radikaalne demokraatia

    Directory of Open Access Journals (Sweden)

    Peeter Selg

    2010-12-01

    Full Text Available Artikkel käsitleb kriitiliselt üht viimaste kümnendite vastandust poliitilises filosoofias — ‘poliitilise liberalismi’ (Rawls ja ‘radikaalse demokraatia’ (Laclau ja Mouffe vahel. Artikkel püüab käivitada potentsiaalset dialoogi nende kahe näiliselt lahkneva lähenemise vahel. Kokkuvõttes näitab artikkel, et vastandus on möödarääkimine vähemalt ühes fundamentaalses mõttes: mõlemad lähenemised jagavad ühiskonnastmõtlemisel sama aluseetost. Artiklis nimetatakse seda ‘sattumuslikkuse eetoseks’ ning väidetakse, et see on kõige fundamentaalsem alusveendumus nii Laclau ja Mouffe’i ‘radikaalse demokraatia’ kui ka Rawlsi ‘õigluse kui ausameelsuse’ idee jaoks. Artikkel osutab ka ühele kesksele kitsaskohale Laclau ja Mouffe’i lähenemises: nende suutmatusele kontseptualiseerida institutsioonilisi korraldusi tulenevalt nende ülemäärasest rõhuasetust demokraatia dekonstruktiivsele potentsiaalile. Selles suhtes osutatakse ka Rawlsi käsitluse ilmselgetele eelistele, kuna see pakub juhiseid organiseerimaks demokraatlikke institutsioone.

  10. [Effects of three Wenyang Jianpi Tang on cell proliferation and apoptosis of nonalcoholic fatty liver cells].

    Science.gov (United States)

    Yang, Jia-Yao; Tao, Dong-Qing; Liu, Song; Zhang, Shu; Ma, Wei; Shi, Zhao-Hong

    2017-04-01

    To investigate the effects of Sijunzi Tang, Lizhong Tang and Fuzi Lizhong Tang on the cell proliferation and apoptosis of nonalcoholic fatty liver cells through the nonalcoholic fatty liver cell model established by inducing L02 cells with oleic acid. Different concentrations of oleic acid were added into L02 cells to induce the nonalcoholic fatty liver cell model. Oil red O staining was used to observe fatty droplets of fatty liver cells. Automatic biochemical analyzer was used to detect the levels of aspartic transaminase(AST), alanine aminotransferase(ALT), total cholesterol(TC), and triglyceride(TG) in the cell supernatants. There were five groups, namely normal group, model group, model and Sijunzi Tang group, model and Lizhong Tang group, and model and Fuzi Lizhong Tang group. The cell proliferation and apoptosis of the five groups were detected by MTT colorimetry test and flow cytometer. The expressions of PCNA, cleaved caspase-3, cleaved caspase-8, cleaved caspase-9, Bax and Bcl-2 proteins of the five groups were detected by Western blot. The oil red O staining results showed that the optimum concentration of oleic acid that was used to induce nonalcoholic fatty liver cell models was 80 mg•L-1. The levels of AST, ALT, TC and TG in the nonalcoholic fatty liver cell supernatants were higher than that in normal liver cell supernatants(PTang, Lizhong Tang and Fuzi Lizhong Tang could effectively promote the cell proliferation, and inhibit the cellular apoptosis of nonalcoholic fatty liver cells(PTang showed the best effect. Western blot results showed that Sijunzi Tang, Lizhong Tang and Fuzi Lizhong Tang could down-regulate the expressions of cleaved caspase-3, cleaved caspase-8, cleaved caspase-9 and Bax proteins, and up-regulate the expressions of PCNA and Bcl-2 proteins of nonalcoholic fatty liver cells. And Fuzi Lizhong Tang showed the best effect. In conclusion, all of Sijunzi Tang, Lizhong Tang and Fuzi Lizhong Tang could effectively promote the cell

  11. Analisis Perbandingan Experiential Value antara Hong Tang dan Black Ball serta Hubungannya dengan Customer Satisfaction

    Directory of Open Access Journals (Sweden)

    Annetta Gunawan

    2014-11-01

    Full Text Available Black Ball and Hong Tang are two pioneers of Taiwanese dessert sellers in Jakarta. Both of them have product offering characteristics that are alike and have the same target market. From the initial observation, the researcher found that even though Black Ball has more outlets than Hong Tang, but Black Ball seems to be less popular than Hong Tang. The consumers’ preferences are varied, there are some consumers prefer Hong Tang, but there are also those who choose Black Ball, because of the food quality, the service provided, and also the experiences they get during the consumption process. Therefore, both Black Ball and Hong Tang have to consider about the experiential value to be offered to their customers, in order to increase their customer satisfaction, so that they can sustainably survive in the midst of challenging competition. The objectives of this research are to examine whether there is any difference of experiential value dimensions and customer satisfaction between Hong Tang and Black Ball and to examine the relationship between experiential value dimensions and customer satisfaction of Hong Tang and Black Ball. The result of this research concludes that there is no difference of all experiential value dimensions and customer satisfaction between Hong Tang and Black Ball and there is a strong and significant relationship between all experiential value dimensions and customer satisfaction of Hong Tang and Black Ball.

  12. Eesti transpordi infrastruktuuri ootavad suured toetused / Tanel Tang

    Index Scriptorium Estoniae

    Tang, Tanel

    2003-01-01

    EL-iga liitumisel avanevad Eestile Euroopa Regionaalarengu fond (ERDF) ja Ühtekuuluvusfond, mis tähendab transpordisektorile miljardite kroonide suurust abi maanteede, raudteede, lennujaamade ning sadamate ehitamiseks ja rekonstrueerimiseks. Vt. samas: Eestile tulnud abi PHARE ja ISPA fondist ; Ühtekuuluvusfond ja Euroopa regionaalarengu fond (ERDF) toetavad Eestit miljonite kroonidega. Diagramm: EL-i abi Eesti transpordisektorile

  13. Numerical modelling of ice floods in the Ning-Meng reach of the Yellow River basin

    NARCIS (Netherlands)

    Wang, C.

    2017-01-01

    The Ning-Meng reach of the Yellow River basin is located in the Inner Mongolia region at the Northern part of the Yellow River. Due to the special geographical conditions, the river flow direction is towards the North causing the Ning-Meng reach to freeze up every year in wintertime. Both during the

  14. Suan Zao Ren Tang in Combination with Zhi Zi Chi Tang as a Treatment Protocol for Insomniacs with Anxiety: A Randomized Parallel-Controlled Trial

    OpenAIRE

    Hu, Lin-lin; Zhang, Xin; Liu, Wen-juan; Li, Mei; Zhang, Yong-hua

    2015-01-01

    Insomnia is a serious worldwide health problem that is often comorbid with anxiety. The purpose of the present study was to evaluate the efficacy of a Chinese formula containing Suan Zao Ren Tang (SZRT) and Zhi Zi Chi Tang (ZZCT; SZR-ZZC) for improving sleep quality and anxiety states with four indices of Polysomnography (PSG), the Insomnia Severity Index (ISI), the Pittsburgh Sleep Quality Index (PSQI), and the Self Rating Anxiety Scale (SAS). Methods. A randomized, parallel-controlled trial...

  15. Two cases of Chest Heating Sensation treated by Hwangryunhaedok-tang Herbal-Acupuncture

    Directory of Open Access Journals (Sweden)

    Gwon-Il Cho

    2003-06-01

    Full Text Available The purpose of this study is to evaluate the clinical effect of Hwangryunhaedok-tang Herbal-Acupuncture. Hwangryunhaedok-tang is used in all heating diseases. Chest Heating Sensation is a unique concept in Oriental Medicine. So we applied Hwangryunhaedok-tang Herbal-Acupuncture to treat the Chest Heating Sensation. We used DITI(Digital Infrared Thermographic Imaging to estimate the temperatures of chest surface for the outcome assessment. We came to know that the chest surface temperatures were all reduced in both cases after Herbal-Acupuncture treatment. The reduced average temperature was 1.5℃ in case 1 and 0.9℃ in case 2. The above result indicates that Hwangryunhaedok-tang Herbal-Acupuncture treatment has an effect on Chest Heating Sensation, thus continuous Hwangryunhaedok-tang Herbal-Acupuncture study will be needed for more clinical applications.

  16. Study of meterial distribution of Tang tricolor from Huangye kiln

    International Nuclear Information System (INIS)

    Dong Junling; Zhao Weijuan; Liu Guodong; Cheng Huansheng; Liao Yongmin; Zhang Songlin

    2008-01-01

    By using the proton induced X-ray enission (PIXE) method, the measurements of the oxide compound content have veen carried out for the selected 18 samples of Tang tricolor in Huangye kiln. For ascertaining the classification and origin relation of the samples the principal component analysis method was adopted, and the results indicate that the chemical compositions of Tang tricolor body with diggerent glaze colors are close, which shows that their raw material habitat distribution is quite concentrative. But the prescriptions of diffierent color glaze are different. The content of CoO is more than others in blue glaze; CuO is more than others in green glaze; Fe 2 O 3 is more than others in brown and yellow glaze; A1 2 O3 is less than others but SiO 2 is more in white glaze, which shows that glazers material origin is diffierent, but brown and yellow glaze are close and even the same in chemistry component. (authors)

  17. Ettevõtte turgu valitsev seisund ning selle kuritarvitamine / Kristi Poogen

    Index Scriptorium Estoniae

    Poogen, Kristi

    1997-01-01

    Turgu valitseva ettevõtte mõistest, kaubaturust ja geograafilisest turust ning turgu valitseva seisundi kuritarvitamisest (ebaõiglased hinnad, diskrimineerimine, seosmüük) vastavalt uuele konkurentsiseaduse eelnõule

  18. Töö ning pidu Cannes ̀is / Jaak Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Jaak, 1955-

    1998-01-01

    Meeleoludest Cannes ̀i 51. filmifestivalil ja lühidalt Terry Gilliani filmist "Ratastel Las Vegasesse" ("Fear and Loathing in Las Vegas") ning Roberto Benigni filmist "Elu on ilus" ("La Vita é bella")

  19. Suurkiskja- ja kotkakahju ennetamise meetmed Eesti ja Soome saartel ning rannikualadel / T. Otstavel

    Index Scriptorium Estoniae

    Otstavel, Teet, 1964-

    2013-01-01

    Uuring käsitleb Eesti ja Soome rannikualade ja saarte loomakasvatajate võimalusi suurendada karjamaadel kaitset suurkiskjate ja merikotkaste vastu ning kasutada suurkiskjate rünnakute ennetamise meetmeid, eelkõige karjavalvekoeri

  20. Hirm taevas ning võit infosõjas / Taavi Minnik

    Index Scriptorium Estoniae

    Minnik, Taavi, 1986-

    2015-01-01

    Venemaa ja Egiptus soovivad Siinai poolsaare lennuõnnetuse põhjusena välistada terrorirünnaku võimaluse, samas kui välismeedias ning Venemaa opositsioonilistes kanalites selle üle aina valjemini arutletakse

  1. Vabadus, võrdsus ja vendlus ning liberaaldemokraatliku riigi üleilmastumine / Leif Kalev

    Index Scriptorium Estoniae

    Kalev, Leif, 1976-

    2011-01-01

    Vabadus, võrdsus ja vendlus liberaaldemokraatlikus riikluses, selle sisepinged ja alternatiivid üleilmastumise kontekstis ning kohasus tänase poliitika ja valitsemise analüüsimisel. Liberalismi rakendustest Eestis

  2. Tang dynasty (618-907) bowl measured with PIXE

    Science.gov (United States)

    Laitinen, M.; Käyhkö, M.; Hahn, G.; von Uexküll-Güldenband, N.; Sajavaara, T.

    2017-09-01

    Brownish bowl originating from an underwater shipwreck located near Belitung island in the Java Sea, some 600 km south-east from Singapore, has been measured with particle induced X-ray emission. This study was a pilot project for the - now a spin-off company - Recenart research team where one target was to evaluate the authenticity of the different type of art objects. PIXE measurements were done from three different material positions from a single bowl received from a customer. These locations were categorized as a bluish/greenish pigment (under glaze), thick glaze and the body clay. When the obtained data was compared to the other references from different dynasties and kiln sites, the closest match was indeed the Tang dynasty, Tongguan/Ghangsha kiln-site potsherds - from where the bowl in question was also suspected to originate.

  3. Literature in Focus L’étang - Mathilde Fontanet

    CERN Document Server

    2009-01-01

    "The Pond" (L’étang), one of the eleven short stories that lends its name to the collection, is the tale of a forty-something woman who, alone and scared on a twenty-four-hour trip to the wilds of Yorkshire, makes a disturbing discovery along a meandering woodland pathway. The characters who haunt these pages - from the chronically shy young librarian or the divided twins, to the obsequious neighbour, the amnesiac aunt or the people encountered on a bus or at the hospital - are neither heroes nor heroines; they’re just people living ordinary lives, unremarkable destinies. These brief encounters, these snapshots of ordinary life, these snippets of existence made up of hesitant dialogue, insignificant gestures and feelings of love, whether acknowledged or not, are retold by Mathilde Fontanet with consummate artistry and restrained emotion. Ordinary they may be, but they leave an indelible impression on us. Wednesday 21 October,...

  4. Effects of Tang Mai Kang Capsule on Angioneurotic Lesions in Alloxan-Induced Diabetic Mice

    Institute of Scientific and Technical Information of China (English)

    李华; 王军; 高丽君; 郭永成

    2004-01-01

    The effects of Tang Mai Kang Capsule (糖脉康胶囊) on blood sugar level, gangrene of the tail-tip, pain threshold and learning and memory abilities were investigated in alloxan-induced diabetic mice. The results showed that Tang Mai Kang Capsule could significantly decrease blood sugar level and incidence rate of gangrene of the tail-tip, increase pain threshold, and strengthen learning and memory abilities, suggesting that Tang Mai Kang Capsule functions to decrease blood sugar level and improve the complicated angioneurotic lesions of diabetes.

  5. Race, Slavery, and the Re-evaluation of the T'ang Canon

    OpenAIRE

    Rutledge, Gregory E.

    2014-01-01

    In his article "Race, Slavery, and the Revaluation of the T'ang Canon" Gregory E. Rutledge re-evaluates—from the purview of African Diaspora literary studies—historiography that considers the place of East African slave lore in T'ang Dynasty fiction. Julie Wilensky's "The Magical Kunlun and 'Devil Slaves': Chinese Perceptions of Dark-skinned People and Africa before 1500" (2002), a revision of Chang Hsing-lang's "The Importation of Negro Slaves to China Under the T'ang Dynasty (A.D. 618-907)"...

  6. [Analysis of chemical constituents of volatile components from Jia Ga Song Tang by GC-MS].

    Science.gov (United States)

    Tan, Qing-long; Xiong, Tian-qin; Liao, Jia-yi; Yang, Tao; Zhao, Yu-min; Lin, Xi; Zhang, Cui-xian

    2014-10-01

    To analyze the chemical components of volatile components from Jia Ga Song Tang. The volatile oils were extracted by water steam distillation. The chemical components of essential oil were analyzed by GC-MS and quantitatively determined by a normalization method. 103 components were separated and 87 components were identified in the volatile oil of Zingiberis Rhizoma. 58 components were separated and 38 components were identified in the volatile oil of Myristicae Semen. 49 components were separated and 38 components were identified in the volatile oil of Amomi Rotundus Fructus. 89 components were separated and 63 components were identified in the volatile oil of Jia Ga Song Tang. Eucalyptol, β-phellandrene and other terpenes were the main compounds in the volatile oil of Jia Ga Song Tang. Changes in the kinds and content of volatile components can provide evidences for scientific and rational compatibility for Jia Ga Song Tang.

  7. A partial entropic lattice Boltzmann MHD simulation of the Orszag-Tang vortex

    Science.gov (United States)

    Flint, Christopher; Vahala, George

    2018-02-01

    Karlin has introduced an analytically determined entropic lattice Boltzmann (LB) algorithm for Navier-Stokes turbulence. Here, this is partially extended to an LB model of magnetohydrodynamics, on using the vector distribution function approach of Dellar for the magnetic field (which is permitted to have field reversal). The partial entropic algorithm is benchmarked successfully against standard simulations of the Orszag-Tang vortex [Orszag, S.A.; Tang, C.M. J. Fluid Mech. 1979, 90 (1), 129-143].

  8. The full-scale process and design changes for elimination of insulation edge separations and voids in tang flap area

    Science.gov (United States)

    Danforth, Richard A.

    1991-01-01

    Qualification of the full-scale process and design changes for elimination of redesigned solid rocket motor tang nitrile butadiene rubber insulation edge separations and voids was performed from 24 March to 3 December 1990. The objectives of this test were: to qualify design and process changes on flight hardware using a tie ply between the redesigned solid rocket motor steel case and the nitrile butadiene rubber insulation over the tang capture features; to qualify the use of methyl ethyl ketone in the tang flap region to reduce voids; and to determine if holes in the separator film reduce voids in the tang flap region. The tie ply is intended to aid insulation flow during the insulation cure process, and thus reduce or eliminate edge unbonds. Methyl ethyl ketone is intended to reduce voids in the tang flap area by providing better tacking characteristics. The perforated film was intended to provide possible vertical breathe paths to reduce voids in the tang area. Tang tie ply testing consisted of 270 deg of the tang circumference using a new layup method and 90 deg of the tang circumference using the current layup methods. Tie ply process success was defined as a reduction of insulation unbonds. Lack of any insulation edge unbonds on the tang area where the new process was used, and the presence of 17 unbonds with the current process, proves the test to be a success. Successful completion of this test has qualified the new processes.

  9. Aspiration pneumonia and bronchopneumonia in progressive supranuclear palsy treated with qing fei tang: two case reports.

    Science.gov (United States)

    Nozaki, Ichiro; Kato-Motozaki, Yuko; Ikeda, Tokuhei; Takahashi, Kazuya; Tagami, Atsuro; Ishida, Chiho; Komai, Kiyonobu

    2015-03-26

    Qing fei tang, which is used for various respiratory diseases, is useful for reducing relapse of aspiration pneumonia and bronchopneumonia in stroke, but the effect remains unknown in Parkinson's syndrome. We report two cases of Japanese patients with progressive supranuclear palsy and relapsing aspiration pneumonia and bronchopneumonia, which was successfully prevented by qing fei tang. Two Japanese men with progressive supranuclear palsy and receiving total enteral feeding (patient one (66-years-old) and patient two (76-years-old)) had experienced recurrent aspiration pneumonia and bronchopneumonia, which was unresponsive to conventional therapy. The respiratory infection developed twice at intervals of two months in patient one, and nine times at almost monthly intervals in patient two. Thereafter, they were given qing fei tang. After administration of qing fei tang, the respiratory infection reoccurred only once; after 5.5 months for patient one, and six months for patient two. Both of our patients clearly showed a reduced incidence of respiratory infection. Both of our patients clearly showed a reduced incidence of respiratory infection after the administration of qing fei tang. Qing fei tang could be useful for the prevention of recurrent aspiration pneumonia and bronchopneumonia in progressive supranuclear palsy.

  10. Cyclic Testing of the 6-Strand Tang and Modified Lim-Tsai Flexor Tendon Repair Techniques.

    Science.gov (United States)

    Kang, Gavrielle Hui-Ying; Wong, Yoke-Rung; Lim, Rebecca Qian-Ru; Loke, Austin Mun-Kitt; Tay, Shian-Chao

    2018-03-01

    In this study, we compared the Tang repair technique with the 6-strand modified Lim-Tsai repair technique under cyclic testing conditions. Twenty fresh-frozen porcine flexor tendons were randomized into 2 groups for repair with either the modified Lim-Tsai or the Tang technique using Supramid 4-0 core sutures and Ethilon 6-0 epitendinous running suture. The repaired tendons were subjected to 2 stage cyclic loading. The survival rate and gap formation at the repair site were recorded. Tendons repaired by the Tang technique achieved an 80% survival rate. None of the modified Lim-Tsai repairs survived. The mean gap formed at the end of 1000 cycles was 1.09 mm in the Tang repairs compared with 4.15 mm in the modified Lim-Tsai repairs. The Tang repair is biomechanically stronger than the modified Lim-Tsai repair under cyclic loading. The Tang repair technique may exhibit a higher tolerance for active mobilization after surgery with less propensity for gap formation. Copyright © 2018 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.

  11. Digitalisering af færdighedstræning og laboratorieøvelser

    DEFF Research Database (Denmark)

    Nørgaard, Cita; Dahl, Mads R; Fridorff-Jens, Peter K.

    2014-01-01

    Dette temanummer af “Læring og Medier” sætter fokus på digitalisering af færdighedstræning og laboratorieøvelser på universiteter og UC’er. Der er mange krav og hensyn, som skal tilgodeses, når vi digitaliserer, og det har altid indflydelse på arbejdsgange, kommunikation og læringen. Helt....... Af eksempler kan nævnes simulerede rollespil, virtuel case undervisning, sproglig færdighedstræning, simulatorer og digitale laboratorier. I dette temanummer lægges der op til, at dele erfaringer og best practice man har gjort sig med digitalisering af færdighedstræning og anden inddragelse af medier...

  12. Effects of Wen Dan Tang on insomnia-related anxiety and levels of the brain-gut peptide Ghrelin

    OpenAIRE

    Wang, Liye; Song, Yuehan; Li, Feng; Liu, Yan; Ma, Jie; Mao, Meng; Wu, Fengzhi; Wu, Ying; Li, Sinai; Guan, Binghe; Liu, Xiaolan

    2014-01-01

    Ghrelin, a brain-gut peptide that induces anxiety and other abnormal emotions, contributes to the effects of insomnia on emotional behavior. In contrast, the traditional Chinese Medicine remedy Wen Dan Tang reduces insomnia-related anxiety, which may perhaps correspond to changes in the brain-gut axis. This suggests a possible relationship between Wen Dan Tang's pharmacological mechanism and the brain-gut axis. Based on this hypothesis, a sleep-deprived rat model was induced and Wen Dan Tang ...

  13. Acute toxicity and genotoxicity study of fermented traditional herb formula Guibi-tang.

    Science.gov (United States)

    Park, Hwayong; Hwang, Youn-Hwan; Yang, Hye Jin; Kim, Hyun-Kyu; Song, Kyung Seuk; Ma, Jin Yeul

    2014-10-28

    Guibi-tang (Guipi-tang in Chinese and Kihi-to in Japanese) is a multi-herb traditional medicine commonly prescribed to treat psychoneurosis in East Asia. Although this medicine has been widely used, there is little available information on the safety and toxicity of Guibi-tang, especially on the fermented one. Guibi-tang, composed of 12 herbs, was fermented with bacteria and lyophilized. Single dose acute toxicity in rats was observed for 14 days after administration. Genetic toxicity of fermented Guibi-tang was evaluated on bacterial reverse mutation in Salmonella and Escherichia spp., chromosome aberrations in Chinese hamster ovary cells, and micronucleus formation in mice. Ingredients in FGBT were identified and quantified by high performance liquid chromatography-mass spectrometry. In acute oral toxicity study, behavior, clinical signs and body weight changes were normal observing in all experimental animals. No revertant colonies were found in any bacterial cultures examined. Morphological or numerical anomalies and significant increased number of aberrant metaphases were not observed. Micronucleus assay showed no significant increases in the frequency of inducing micronuclei in any dose examined. Decursinol, decursin, glycyrrhizin, and 6-gingerol in fermented Guibi-tang were identified and quantitated. As a whole, no acute and genotoxic effects were found in all the assays and parameters analyzed. Fermented Guibi-tang was recognized as safe and non-toxic, and therefore can be used for applications of traditional medicine in modern complementary and alternative therapeutics and health care. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  14. Assessment of absorption of four lignan constituents of JingNing ...

    African Journals Online (AJOL)

    Purpose: To study small intestinal absorption of schisadrol A, schisandrol B, schizandrin A and schisandrin B in JingNing particles using in situ single-pass intestinal perfusion (SPIP). Methods: Absorption rate constant (Ka) and apparent permeability (Papp) of the drugs at different concentrations in various parts of rat small ...

  15. Valitud ja valitsenud : Eesti parlamentaarsete ja muude esinduskogude ning valitsuste isikkoosseis aastail 1917-1999 / Olev Olesk

    Index Scriptorium Estoniae

    Olesk, Olev, 1921-2017

    1999-01-01

    rets. rmt.: Valitud ja valitsenud : Eesti parlamentaarsete ja muude esinduskogude ning valitsuste isikkoosseis aastail 1917-1999 / koostaja Jaan Toomla. Tallinn : Eesti Rahvusraamatukogu, 1999. 474 lk.

  16. Miljøforholdene i Tange Sø og Gudenåen

    DEFF Research Database (Denmark)

    Nielsen, K.; Jensen, J. P.; Skriver, J.

    FORORD: Denne rapport er udarbejdet af Danmarks Miljøundersøgelser i forbindelse med høring om Tange Sø arrangeret af Viborg Amt i september 1998. Rapportens formål er at belyse de miljømæssige konsekvenser af syv fremkomne løsningsforslag til forbedring af passageforholdene ved Tangeværket......-20 betød, at ca. 13 km af Gudenåen blev omdannet til Tange Sø. Tange Sø blev anlagt der, hvor Gudenåens fald var størst. Anlæggelsen af Tange Sø medførte store fysiske ændringer i Gudenåen, idet de mest strømfyldte lokaliteter forsvandt. Dermed blev Gudenåens fysiske variation mindre, hvilket har påvirket...... plante- og dyreliv. Etableringen af Tangeværket bevirkede endvidere, at passageforholdene for fisk og smådyr blev stærkt forringet. Bygningen af fisketrappen har kun afhjulpet de dårlige passageforhold i begrænset omfang. Gennem de sidste 20 år er fosfortilførslen til Tange Sø formindsket fra ca. 100 til...

  17. An experimental study of mechanism in treatment for endometriosis with Xiao Chai Hu Tang in rats

    International Nuclear Information System (INIS)

    Zhang Hui; Zuo Liandong; Li Hongyi

    2005-01-01

    To explore the mechanism of Xiao Chai Hu Tang in treatment for endometriosis in rats, the rat model of endometriosis was established. Using immunohistochemistry method, Fas and Caspase-3 protein expression in endometrium and endometriotic tissue of each group were observed. The results showed that in the group treated with Xiao Chai Hu Tang, the protein expressions of Fas and Caspase-3 in endometriotic tissue were higher than those in endometrium, while in the control group, the result was just opposite. The difference was not obvious in the group treated with Danazol . The higher levels of the protein expression of Fas in endometriotic tissue may related to the pathogenesis of the endometriosis. The mechanism of Xiao Chai Hu Tang treatment may be partly to increase apoptosis in endometriotic tissue. (authors)

  18. Tidlig struktureret mobilisering og træning af kritisk syge patienter på et dansk intensivafsnit

    DEFF Research Database (Denmark)

    Astrup Sørensen, Katrine; Hvid, Sidsel; Rolving, Nanna

    2015-01-01

    derimod anvendelig i forhold til at tilpasse niveauet for mobilisering og træning. Relevans for klinisk praksis: Tidlig mobilisering og træning er mulig at indføre med en simpel algoritme, dog med hensyntagen til individuelle screeningskriterier fra sted til sted, da disse åbenbart ikke er nemme...

  19. [Clinical observation on idiopathic tinnitus treated with acupuncture, buzhong yiqi tang and cizhu wan].

    Science.gov (United States)

    Chen, Surong; Tan, Xuming; Fei, Lanbo; Xiang, Xiande

    2018-04-12

    To observe the differences in the clinical therapeutic effects on idiopathic tinnitus between the combined therapy with acupuncture and the modified formula of buzhong yiqi tang and cizhu wan and the simple administration of the modified formula of buzhong yiqi tang and cizhu wan . A total of 60 patients were randomized into a combined treatment group and an herbal medicine group, 30 cases in each one and 2 cases dropped out in the herbal medicine group. In the combined treatment group, acupuncture was given at the local acupoints for tinnitus, such as Yifeng (TE 17), penetrating needling technique from Ermen (TE 21) to Tinggong (SI 19) and Tinghui (GB 2) combined with the scalp acupuncture [the vertigo-auditory area, Baihui (GV 20)] and the oral administration of the modified formula of buzhong yiqi tang and cizhu wan . In the herbal medicine group, the oral administration of the modified formula of buzhong yiqi tang and cizhu wan was only applied. The treatment was given once a day in each group, 5 times a week for acupuncture and 7 times a week for the oral administration of herbal medicine. Totally, the treatment for 6 weeks was required in the two groups. Before and after treatment, the tinnitus severity score (TSS) and the score of tinnitus handicap inventory (THI) were observed and the clinical therapeutic effects were compared between the two groups. After treatment, the TSS and THI scores reduced as compared with those before treatment in the two groups (all P tang and cizhu wan achieve the superior therapeutic effects on idiopathic tinnitus as compared with the simple oral administration of the modified formula of buzhong yiqi tang and cizhu wan .

  20. Maps of Relocation and Poems of Tang Dynasty Poets: Li Bai, Du Fu, and Han Yu

    Directory of Open Access Journals (Sweden)

    羅鳳珠、白璧玲、廖泫銘、范毅軍 、鄭錦全 Feng-Ju Lo,Pi-Ling Pai,Hsiung-Ming Liao,I-Chun Fan,Chin-Chuan Cheng

    2014-04-01

    Full Text Available Geographic environments affect literary contents and genre and thus, since ancient times, geographical area has been used to classify Chinese literature. In 1936 Liang Qichao was keenly aware of the relationship between literature and geography and brought up the idea of “literarygeography”. In 1979 Professor Chen Zhengxiang produced maps of birthplaces of Tang and Song poets to show the shift of Chinese cultural center from north to south. Furthermore, in the pastdecade, the attention to research in literary geography and geographical distribution of writersgradually increased. However, most studies focused on geographical distribution of birthplaces of writers and very few focused on the relationship between poets’ journey and the contents of their writings and their geographic environment. Meanwhile, geographic information system and aerialphotography have developed quickly and have become useful tools for the study of literary geography.Since then, the academic circles in Taiwan have built a solid foundation in this area. While Li Baiand Du Fu were called poetic immortal and poetic sage of the middle and end periods of the heydayof Tang Dynasty, respectively, Han Yu advocated the classical Chinese movement and becameone of the eight great authors of Tang and Song dynasties. Han Yu was also the best representative of Middle Tang poets. While the styles of these three poets differed from each other, they held key positions in the development and evolution of Tang poetry. Their footprints spread all over the countryand greatly affected later developments and contemporary of poetry. This project makes use of the digital Tang Dynasty maps by Tan Qixiang, Tang Dynasty transportation route maps by Yan Gengwang,aerial maps, the All Tang Poems, and chronicles of the poets to build the three poets’ relocation maps and study their poetic literature, language, geography, and interactions with others, in hopesof opening a new research direction

  1. [Medical application of the art of supplication before the Tang dynasty].

    Science.gov (United States)

    Ding, Yuan; Ding, Jieyun; Zhang, Ruqing

    2015-05-01

    Ample materials on diseases treated with supplication were seen on excavated texts, medical works from ancient time, and religious works before the Tang dynasty (including Tang dynasty). Since the breaking up of witchcraft from medicine, there are still supplication applied in the treatment and prevention of diseases, including those of internal medicine, external medicine, women's and children's diseases, disease of the sense organs, and infections. There are dual reasons for this phenomena, one being the diseases caused by spirit and ghostss; and the other being certain effectiveness of this art on some diseases not cured by other regular treatments, hence, its acceptance by secular people.

  2. [Influences of Confucianism, Taoism and Buddhism on Chinese Medical Formulas in Jin-Tang Dynasties].

    Science.gov (United States)

    Wu, Xiao-xiang

    2006-04-01

    In the Jin-Tang Dynasties, when Confucianism, Taoism and Buddhism contended, conflicted and well blent, forming a state of mingled thoughts of the three sects. It exerted profound influences on Chinese Medical Formulas and promoted the academic fashion of compiling books about medical formulas characterized by collecting various formulas especially the simple and proved recipes. This plays a role in the formation of the formulas used in the Jin-Tang Dynasties, featuring simplicity, convenience, cheapness, and effectiveness, different from those of other periods.

  3. Inre och yttre motivation till träning : en kvalitativ studie bland regebundet aktiva kvinnor

    OpenAIRE

    Jonsson, Johanna

    2015-01-01

    Bakgrund: Regelbunden träning är viktig för både fysiskt och psykisktvälbefinnande. För att bibehålla en regelbundenhet i träningen krävs det ettengagemang och en motivation. En person kan motiveras av både inre ochyttre faktorer beroende på personens intresse. Trots att människor tenderaratt vara mer stillasittande, tycks intresset för träning och hälsa öka. Inteminst syns detta på sociala medier, där bilder och inlägg medträningsbudskap förmedlas frekvent. Syfte: Studiens syfte är att under...

  4. Athena konverentsi- ja kultuurikeskus ning restoran Volga = Athena Conference and Cultural Centre and Volga Restaurant

    Index Scriptorium Estoniae

    2008-01-01

    Athena konverentsi- ja kultuurikeskuse ning restorani Volga sisekujundusest (Tartus Küütri 1 asuva Athena kinohoone renoveerimine). Sisearhitekt: Aivar Roosaar. Restaureeriti ka muinsuskaitse alla kuuluvad Ferdi Sannamehe neoklassitsistlikud stukkreljeefid kinosaali seintel ja Peet Areni maalid restorani vitraažlaega keldrisaali nishshides. A. Roosaarest, tema tähtsamad tööd. I-III korruse, vahekorruse ja pööningu plaan, värv. välisvaade, 15 sisevaadet, foto A. Roosaarest

  5. [Metabonomics on toxicity reduction of Glycyrrhizae Radix et Rhizoma for Aconiti Lateralis Radix Preparata in Sini Tang].

    Science.gov (United States)

    Li, Ying; Fu, Chao-Mei; Peng, Wei; Li, Bo; Fu, Shu; Zhang, Hui-Min

    2016-04-01

    To analyze the endogenous metabolite changes in rat plasma after intervention by Sini Tang and Sini Tang without Glycyrrhizae Radix et Rhizoma based on GC-MS metabonomics technology, and study the toxicity reduction effect of Glycyrrhizae Radix et Rhizoma in Sini Tang on Aconiti Lateralis Radix Preparata. Eighteen SD rats were randomly divided into normal group, Sini Tang group and Sini Tang without Glycyrrhizae Radix et Rhizoma group on average. The rats in Sini Tang group and Sini Tang without Glycyrrhizae Radix et Rhizoma group were treated respectively with physic liquor by intragastric administration at the dose of 0.02 mL•g ⁻¹ (equivalent to 0.8 g•mL ⁻¹ crude drugs) once a day for 7 days. The rats in normal group were given with equal volume of saline solution. The plasma samples were collected from each rat 0.5 h after the last administration for GC-MS detection. The data was used for multivariate statistical analysis to obtain 14 potential metabolic markers(13 of them were identified). Then their relative content and metabolic pathways were analyzed. Compared with Sini Tang without Glycyrrhizae Radix et Rhizoma group, seven metabolic markers of were reduced in Sini Tang group. Analysis on physiological functions of these potential metabolic markers showed that the Glycyrrhizae Radix et Rhizoma in Sini Tang could reduce the toxicity of Aconiti Lateralis Radix Preparata by adjusting the glycolysis, lipid metabolism, citrate cycle and some amino acids metabolism. Copyright© by the Chinese Pharmaceutical Association.

  6. The quark induced Mueller-Tang jet impact factor at next-to-leading order

    CERN Document Server

    Hentschinski, M.; Murdaca, B.; Vera, A. Sabio

    2014-01-01

    We present the NLO corrections for the quark induced forward production of a jet with an associated rapidity gap. We make use of Lipatov's QCD high energy effective action to calculate the real emission contributions to the so-called Mueller-Tang impact factor. We combine them with the previously calculated virtual corrections and verify ultraviolet and collinear finiteness of the final result.

  7. An overview of the China Bioanalytical Forum: interview with Daniel Tang.

    Science.gov (United States)

    Tang, Daniel

    2017-02-01

    Daniel Tang talks to Sankeetha Nadarajah, Commissioning Editor (Bioanalysis), regarding the China Bioanalysis Forum (CBF), in which Daniel was one of the co-founders and remains as its co-chair. Daniel is currently the CEO of UP Pharma, a biologics focused bioanalytical CRO in China.

  8. Rap and Resistance: A Social Movement of the Wu-Tang Clan.

    Science.gov (United States)

    Chasteen, Amy L.; Shriver, Thomas

    1998-01-01

    Examines specific collective identity and political expression of the rap group the Wu-Tang Clan. Reveals a multi-layered political strategy that has been conscientiously designed and implemented to instigate a social movement. Prioritizes the voices of marginalized Black peoples and provides raw narratives about oppression. (MMU)

  9. The herbal mixture Xiao-Chai-Hu Tang (XCHT) induces apoptosis of ...

    African Journals Online (AJOL)

    Background: Xiao-Chai-Hu Tang (XCHT) is an extract of seven herbs with anticancer properties, but its mechanism of action is unknown. In this study, we evaluated XCHT-treated hepatocellular carcinoma (HCC) for anti-proliferative and pro-apoptotic effects. Materials and Methods: Using a hepatic cancer xenograft model, ...

  10. L'étang de Dombes. Insertion dans le paysage agraire

    Directory of Open Access Journals (Sweden)

    BILLARD A.

    1979-01-01

    Full Text Available Les étangs constituent en Dombes centrale un élément original et un facteur de complexité du paysage agraire. Ils sont situés dans des dépressions au sol imperméable établies entre des collines glaciaires barrées par des digues d'argile et sont de forme irrégulière ; leur alimentation est à peu près exclusivement assurée par les eaux de pluie. Ces étangs, d'une superficie courante de 20 à 30 ha, sont soumis à un assolement pas toujours régulier qui fait alterner la production de poissons (évolage et la production de céréales ou de mais (assec. Constituant un niveau de base local, la nappe d'eau de l'étang en évolage limite les phénomènes d'érosion et assure un rôle d'équilibre. L'étang représente une forme d'adaptation aux conditions naturelles mais il est indissociable des formes d'habitat dispersé et des grandes parcelles de l'exploitation d'un seul tenant. L'origine des étangs remonte au Moyen-Age. Mais le rythme des constructions se serait accéléré à partir des 15ème et 16ème siècles. L'analyse du paysage agraire, Jointe aux données d'un manuscrit en date de 1704, suggère que le développement des étangs serait lié à un phénomène de concentration foncière qui a donné naissance aux grands domaines de la Dombes. Avec sa production de poisson réservé au propriétaire à l'exclusion des paysans, l'étang représentait dans une région, alors très pauvre, l'introduction de l'économie de marché.

  11. Euiiyin-tang in the treatment of obesity: study protocol for a randomised controlled trial.

    Science.gov (United States)

    Cheon, Chunhoo; Jang, Soobin; Park, Jeong-Su; Ko, Youme; Kim, Doh Sun; Lee, Byung Hoon; Song, Hyun Jong; Song, Yun-Kyung; Jang, Bo-Hyoung; Shin, Yong-Cheol; Ko, Seong-Gyu

    2017-06-21

    Obesity is a public health concern in many countries due to its increasing prevalence. Euiiyin-tang is an herbal medicine formula often used as a clinical treatment for obesity. It acts to eliminate humidity and purify the blood, the causes of obesity identified by the theoretical framework of Korean medicine. The purpose of this study is to evaluate the efficacy and safety of Euiiyin-tang in treating obesity. This study is a randomised, double-blinded and placebo-controlled, multicentre trial. It has two parallel arms: the Euiiyin-tang group and the placebo group. A total of 160 obese adult women will be enrolled in the trial. The participants will be randomly divided at a 1:1 ratio at visit 2 (baseline). The participants will be administered Euiiyin-tang or placebo for 12 weeks. The primary endpoint is the change in weight occurring between baseline and post-treatment. The secondary outcomes include average weight reduction, changes in body fat, waist and hip circumferences, body mass index, and lipid profile, and the results of questionnaires such as the Korean version of Obesity-related Quality of Life, the Korean version of Eating Attitudes Test, the Social Readjustment Rating Scale, and the Stress Reaction Inventory. The present study will provide research methodologies for evaluating the efficacy and safety of Euiiyin-tang in patients with obesity. In addition, it will provide evidence of correlation between obesity and Sasang constitutional medicine. ClinicalTrials.gov, NCT01724099 . Registered on 2 November 2012.

  12. Sagunja-Tang Improves Lipid Related Disease in a Postmenopausal Rat Model and HepG2 Cells

    Directory of Open Access Journals (Sweden)

    Hiroe Go

    2015-01-01

    Full Text Available The present study was conducted to investigate the effect of Sagunja-tang on the lipid related disease in a rat model of menopausal hyperlipidemia and lipid accumulation in methyl-β-cyclodextrin-induced HepG2 cells. In in vivo study using menopausal hyperlipidemia rats, Sagunja-tang reduced retroperitoneal and perirenal fat, serum lipids, atherogenic index, cardiac risk factor, media thickness, and nonalcoholic steatohepatitis score, when compared to menopausal hyperlipidemia control rats. In HepG2 cells, Sagunja-tang significantly decreased the lipid accumulation, total cholesterol levels, and low-density/very-low-density lipoprotein levels. Moreover, Sagunja-tang reversed the methyl-β-cyclodextrin-induced decrease in the protein levels of critical molecule involved in cholesterol synthesis, sterol regulatory element binding protein-2, and low-density lipoprotein receptor and inhibited protein levels of 3-hydroxy-3-methylglutaryl coenzyme A reductase as well as activity. Phosphorylation level of AMP-activated protein kinase was stimulated by Sagunja-tang. These results suggest that Sagunja-tang has effect on inhibiting hepatic lipid accumulation through regulation of cholesterol synthesis and AMPK activity in vitro. These observations support the idea that Sagunja-tang is bioavailable both in vivo and in vitro and could be developed as a preventive and therapeutic agent of hyperlipidemia in postmenopausal females.

  13. Ning Wang, Making a Market Economy; Yan Sun, Corruption and Market in Contemporary China

    OpenAIRE

    Guiheux, Gilles

    2008-01-01

    These two works shed light on the conditions under which, in the course of the last 25 years, the command economy has been dismantled and gradually replaced by a market system in China . Yan Sun, a professor of political science, is interested in corruption from a double perspective, both at the macro and the micro level. Ning Wang, a neo-institutionalist economist, asks how, thanks to the reforms, a region (Jingzhou, south of Hubei ) has been converted to pisciculture. Corruption is a crucia...

  14. Randomiseret klinisk undersøgelse af effekten af kognitiv adaptationstræning: design og metodediskussion

    DEFF Research Database (Denmark)

    Hansen, Jens Peter; Østergaard, Birte; Nordentoft, Merete

    2009-01-01

      Kognitiv adaptations træning er afprøvet gennem randomiserede studier i udlandet, men er ikke afprøvet på nydebuterede patienter, som modtager intensiv pleje og behandling. I denne artikel præsenteres et forskningsprojekt, som skal afgøre om kognitiv adaptations træning er velegnet i en dansk...... kontekst som supplement til nuværende tilbud til patienter med debuterende skizofreni. Studiet gennemføres som et randomiseret multicenter forsøg, hvor 164 konsekutivt inkluderede patienter fordeles til henholdsvis kognitiv adaptations træning og standardbehandling. Effekten af interventionen evalueres med......, fordelingsprocedure, bortfald, udvælgelse af patienter og sammenlignelighed mellem tilknyttede centre. Dette studie er det første studie, hvor kognitiv adaptations træning sammenlignes med et ambulant tilbud bestående af psykiatrisk behandling kombineret med hyppige hjemmebesøg ved distriktssygeplejersker. Studiet...

  15. Investeerija märksõnad : USA ning tervishoiu- ja IT-sektor / Uwe Zöllner

    Index Scriptorium Estoniae

    Zöllner, Uwe

    2008-01-01

    USA elanike tarbimise mõjust globaalsele majandusruumile. Aktsiainvesteeringuid plaanides tasuks silmas pidada tervishoiu- ja infotehnoloogiasektori ettevõtteid ning vaadata USA poole. Lisa: Hiina eksport võrreldes riigisisese tarbimisega

  16. Tidal triggering of earthquakes in the Ning'er area of Yunnan Province, China

    Science.gov (United States)

    Xie, Chaodi; Lei, Xinglin; Zhao, Xiaoyan; Ma, Qingbo; Yang, Simeng; Wang, Yingnan

    2017-05-01

    To investigate the potential effect of tidal modulation on the seismicity in the Ning'er area, a seismically and geothermally active zone in Yunnan Province, China, we studied the correlation between Earth tides and the occurrence of M ≥ 6.0 earthquakes dating back to 1970, as well as their aftershock sequences, using theoretically calculated tidal stresses and a statistical test. The results show a significant correlation between Earth tides and the occurrence of earthquakes. Six of seven main events occurred when the Earth tide increased the Coulomb failure stress on the source fault. Four main events occurred in a narrow range of phase angle corresponding to the maximum loading rate of tidal stress. Furthermore, the histories of the aftershock sequence as a function of the tidal phases demonstrate clear tidal modulation with a high significance. Thus, we conclude that Earth tides have a clear role in triggering (or modulating) the rupture of the fault systems in the Ning'er area.

  17. Neutron activation analysis of the arovenance relation of tang tri-color glazed potteryies of huangye kiln and yaozhou kiln

    International Nuclear Information System (INIS)

    Li Guoxia; Zhao Weijuan; Gao Zhengyao; Xie Jianzhong; Guo Min

    2006-01-01

    The technique of neutron activation analysis (NAA) has been employed to measure the content of 29 kinds of elements in the Tang Tri-color glazed potteryies of Huangye kiln and Yaozhou kiln. Then a fuzzy cluster analysis has been conducted to the NAA data. The results indicate that the places of origin of raw materials of body samples in the Tang Tri-color glazed potteryies of Huangye kiln are very concentrated, and that the places of origin of raw materials of body and glaze samples are scattered the places of origin of raw materials of the body and glaze raw material cover that of the body raw material. The source of raw materials of samples in the Tang Tri-color glazed potteryies of Huangye kiln is obviously different from that of samples in the Tang Tri-color glazed potteryies of Yaozhou kiln. (authors)

  18. Acute Hepatitis Induced by Chinese Hepatoprotective Herb, Xiao-Chai-Hu-Tang

    Directory of Open Access Journals (Sweden)

    Li-Ming Hsu

    2006-02-01

    Full Text Available Xiao-chai-hu-tang (syo-saiko-to in Japanese is a herbal remedy that has been widely used in China for treatment of respiratory, hepatobiliary, and gastrointestinal diseases, particularly among patients with chronic liver disease. However, its safety has recently been challenged. We, herein, report a Chinese patient with acute hepatitis induced by this herb. A 52-year-old woman presented with weakness, fatigue, and tea-colored urine after continual consumption of the decoction of xiao-chai-hu-tang for 1.5 months. Laboratory studies disclosed acute hepatitis even though all of the viral hepatitis markers were negative. Liver biopsy also revealed a picture of acute hepatocellular hepatitis. The symptoms improved after discontinuing the drug, and liver biochemical tests normalized 2 months later. The case report reminds us of the probable adverse drug reaction of herbs, even in some that are claimed to have hepatoprotective effects.

  19. Blå biomasse – potentialer og udfordringer for opdræt af muslinger og tang

    DEFF Research Database (Denmark)

    Petersen, Jens Kjerulf; Bjerre, Anne-Belinda; Hasler, Berit

    pdræt af muslinger og tang bygger på et fælles princip: Næringssalte i havet omsættes enten direkte gennem fotosyntese (tang) eller indirekte via filtrering af fytoplankton (muslinger) til bio-masse. Det kræver således ikke nogen form for fodring med dertil hørende miljøbelastning at dyrke...... muslinger og tang i havet og opdrættet kan øko-certificeres. Når muslingerne eller tangen bliver høstet, bringes næringssalte - der oprindeligt er tabt fra land - tilbage til land, og opdræt af muslinger og tang repræsenterer derfor et helt fundamentalt eksempel på cirkulær økonomi. Næringsrige kystvande......,5-14,6 mio. kr. årligt, mens en produktion på 100.000 tons muslinger, svarende til ca. 15.000 tons mel, vil levere økosystem tjenester for 91-293 mio. kr. årligt. Opdræt af tang i danske kystnære farvande er udfordret af store områder med for lav salthol-digheder og dårlige lysforhold. Opdræt af tang er et...

  20. The Gluon-Induced Mueller-Tang Jet Impact Factor at Next-to-Leading Order

    CERN Document Server

    Hentschinski, Martin; Murdaca, Beatrice; Vera, Agustín Sabio

    2014-01-01

    We complete the computation of the Mueller-Tang jet impact factor at next-to-leading order (NLO) initiated in arXiv:1406.5625 and presented in arXiv:1404.2937 by computing the real corrections associated to gluons in the initial state making use of Lipatov's effective action. NLO corrections for this effective vertex are an important ingredient for a reliable description of large rapidity gap phenomenology within the BFKL approach.

  1. Suan Zao Ren Tang in Combination with Zhi Zi Chi Tang as a Treatment Protocol for Insomniacs with Anxiety: A Randomized Parallel-Controlled Trial

    Science.gov (United States)

    Hu, Lin-lin; Zhang, Xin; Liu, Wen-juan; Li, Mei; Zhang, Yong-hua

    2015-01-01

    Insomnia is a serious worldwide health problem that is often comorbid with anxiety. The purpose of the present study was to evaluate the efficacy of a Chinese formula containing Suan Zao Ren Tang (SZRT) and Zhi Zi Chi Tang (ZZCT; SZR-ZZC) for improving sleep quality and anxiety states with four indices of Polysomnography (PSG), the Insomnia Severity Index (ISI), the Pittsburgh Sleep Quality Index (PSQI), and the Self Rating Anxiety Scale (SAS). Methods. A randomized, parallel-controlled trial compared SZR-ZZC to lorazepam tablet in insomniacs with anxiety. Patients were randomized to the SZR-ZZC treatment group (n = 60) and the lorazepam tablet treatment group (n = 59). Results. SZR-ZZC significantly improved scores on all four treatment indices. Compared with lorazepam, treatment with SZR-ZZC resulted in a significant reduction in the ISI (P = 0.029), the PSQI (P = 0.017), and wake after sleep onset (WASO; P = 0.008) scores and improved sleep architecture (P = 0.000–0.003) after a 4-week treatment period. Only one subject in the SZR-ZZC group experienced adverse side effects. Conclusion. Treatment with SZR-ZZC for 4 weeks appears to be a relatively safe and effective complementary therapeutic option when aiming to improve sleep quality and anxiety in insomniacs with anxiety. PMID:25793006

  2. Suan Zao Ren Tang in Combination with Zhi Zi Chi Tang as a Treatment Protocol for Insomniacs with Anxiety: A Randomized Parallel-Controlled Trial

    Directory of Open Access Journals (Sweden)

    Lin-lin Hu

    2015-01-01

    Full Text Available Insomnia is a serious worldwide health problem that is often comorbid with anxiety. The purpose of the present study was to evaluate the efficacy of a Chinese formula containing Suan Zao Ren Tang (SZRT and Zhi Zi Chi Tang (ZZCT; SZR-ZZC for improving sleep quality and anxiety states with four indices of Polysomnography (PSG, the Insomnia Severity Index (ISI, the Pittsburgh Sleep Quality Index (PSQI, and the Self Rating Anxiety Scale (SAS. Methods. A randomized, parallel-controlled trial compared SZR-ZZC to lorazepam tablet in insomniacs with anxiety. Patients were randomized to the SZR-ZZC treatment group (n=60 and the lorazepam tablet treatment group (n=59. Results. SZR-ZZC significantly improved scores on all four treatment indices. Compared with lorazepam, treatment with SZR-ZZC resulted in a significant reduction in the ISI (P=0.029, the PSQI (P=0.017, and wake after sleep onset (WASO; P=0.008 scores and improved sleep architecture (P=0.000–0.003 after a 4-week treatment period. Only one subject in the SZR-ZZC group experienced adverse side effects. Conclusion. Treatment with SZR-ZZC for 4 weeks appears to be a relatively safe and effective complementary therapeutic option when aiming to improve sleep quality and anxiety in insomniacs with anxiety.

  3. Utilisation du phytoplancton pour estimer la production piscicole potentielle des étangs

    Directory of Open Access Journals (Sweden)

    BARBE J.

    1999-07-01

    Full Text Available Pour faciliter la gestion des étangs de pisciculture, il est nécessaire d'avoir un moyen pour estimer en cours de saison si l'objectif de production sera atteint, et éventuellement, intervenir sur la qualité du milieu. Les méthodes d'estimation et de prévision mentionnées dans la littérature ne sont pas applicables aux étangs de pisciculture, milieux fortement anthropisés. A partir de données (physico-chimie, plancton, production piscicole collectées sur 36 étangs en France, les auteurs proposent une méthode de prévision de la récolte piscicole à partir du phytoplancton (groupe prédominant et teneur en chlorophylle a. A l'usage, cette méthode s'est avérée satisfaisante pour prévoir des productions nettes jusqu'à plus de 500 kg/hectare.

  4. The effect of Ga-mee-gwui-ryong-tang and Yuk-mee ji-hwang-tang Herbal-acupuncture on the growth of mice

    Directory of Open Access Journals (Sweden)

    Min-jung Kim

    2006-12-01

    Full Text Available Objectives : To investigate the effect of Ga-mee-Gwui-ryong-tang herbal acupuncture (GR-HA at GB39 and ST36 and the effect of Yuk-mee ji-hwang-tang herbal acupuncture (YM-HA at GB39 and KI10 on growth in mice. Methods : Mice were divided into 7 groups(n=10 ; saline-ST36, saline-GB39, saline-KI10, GR-HA-ST36 group treated with GR-HA at right ST36, GR-HA-GB39 group treated with GR-HA at right GB39, YM-HA-GB39 group treated with YM-HA at right GB39, YM-HA-KI10 group treated with YM-HA at right KI10. Saline-ST36 group, saline-GB39 group and saline-KI10 group were injected with saline at right ST36, GB39, KI10 respectively. Saline injection and HA were performed 3 times a week for 18 days. The length(total height, body length and tail length, weight and the protein efficiency ratio were measured as well as IGF-1 level in serum. Results : 1. GR-HA at GB39 and GR-HA at ST36 promoted growth in weight, tail length and total height but there was no statistical significance. 2. GR-HA at GB39 significantly promoted protein efficiency on the 14th day and GR-HA at ST36 on the 3rd day. 3. GR-HA at GB39 significantly increased serum IGF-1. GR-HA at ST36 increased IGF-1 slightly but with no statistical significance. 4. YM-HA at GB39 and YM-HA at KI10 promoted growth in weight, height, tail length and total height but there was no statistical relevance. 5. YM-HA at GB39 and YM-HA at KI10 significantly promoted protein efficiency on the 14th day. 6. YM-HA at GB39 and YM-HA at KI10 significantly increased serum IGF-1. Serum IGF-1 level of YM-HA-KI10 group was significantly higher than that of YM-HA-GB39 group. 7. Serum IGF-1 level of GR-HA-GB39 group was significantly higher than that of YM-HA-GB39 group. Conclusions : GR-HA and YM-HA both may promote growth. This study suggests that herbal acupuncture at GB39 is more effective with Gwui-ryong-tang than Yuk-mee ji-hwang-tang to promote growth. It also suggests that Yuk-mee ji-hwang-tang herbal acupuncture is more

  5. Kliniske retningslinjer for træning af aerob kapacitet og muskelstyrke til patienter med reumatoid artrit

    DEFF Research Database (Denmark)

    Larsen, Birgit Tine; Læssøe, Uffe; Kjær, Thomas

    forstærker denne risiko. Formål: Gennem effektiv og sikker træning at øge RA patienters aerob kapacitet og muskel styrke for dermed atlette patienternes daglige aktiviteter. Patienter: Voksne patienter (> 18 år) med diagnosen reumatoid artrit ifølge ARA eller ACR/EULAR kriterierne,funktionsklasserne I, II og...... III, i primær eller sekundær sektoren. Intervention/er: Kortvarig land- eller vandbaseret højintensitets træning af aerob kapacitet, kortvarig eller længerevarendeland-baseret høj-intensitets træning af aerob kapacitet i kombination med muskelstyrke træning oglængerevarende land-baseret høj......-intensitets styrke træning. Inkluderet studier: Èt systematisk review og to randomiseret klinisk kontrolleret studier (RCT). Outcomes: Aerob kapacitet, maksimal muskelstyrke, selv-rapporteret smerte, funktionsevne, sygdomsaktivitet,radiologisk ledskade og uønskede bivirkninger. Søgestrategi:Følgende databaser blev...

  6. Elemental analyses on porcelains of Tang and Song Dynasties excavated from Yongjinwan zone at Jinsha site

    Science.gov (United States)

    Xia, C. D.; Ge, L. J.; Liu, M. T.; Zhu, J. J.; An, Z.; Bai, B.

    2018-02-01

    The work presented here carried out elemental analyses on 60 porcelain shards of Tang and Song Dynasties, unearthed from Yongjinwan zone at Jinsha site, Sichuan, China, using a combination of PIXE and RBS methods. Six shards from Liulichang kiln site and 6 from Shifangtang kiln site were also analyzed as reference materials. The factor analyses for the elemental compositions in the bodies and glazes of the total 72 porcelain shards have been performed to explore their similarities and differences. Combining the results of factor analyses on elements in bodies and glazes and the classification by traditional archaeological criteria, the provenances for most of shards unearthed from Yongjinwan zone in Jinsha site could be determined. Majority of shards with a Qiong-kiln style were found as products of Liulichang kiln, this is consistent with Yongjinwan's geographical location and social environment, i.e., Yongjinwan was a suburban settlement nearest to Liulichang kiln in ancient times. Although both products of Liulichang kiln and Shifangtang kiln belonged to Qiong-kiln system and they shared a similar appearance such as red body and celadon glaze, there were distinct differences in chemical composition which could be unraveled by PIXE-RBS measurements and factor analysis. There were no apparent differences of chemical compositions for the same kinds of body and glaze between Tang and Song Dynasties, which may suggest that raw materials and production techniques for the same kinds of body and glaze continued between Tang and Song Dynasties. The chemical characteristics for each kind of body and glaze and the correlations between element composition and porcelain appearance were also obtained in this work.

  7. [Evaluation study on integration effect of taohong siwu tang in treating primary dysmenorrhea].

    Science.gov (United States)

    Liu, Li; Duan, Jin-Ao; Hua, Yong-Qing; Liu, Pei; Shang, Er-Xin; Tang, Yu-Ping; Su, Shu-Lan

    2012-11-01

    To evaluate the effect of Taohong Siwu Tang and its fractions on hotplate-induced pain in mice, acetic acid-induced writhing response, dysmenorrheal model and isolated uterine contraction in vitro in mice, and discuss material basis of effect sites. The samples of fractions were prepared by macroporous adsorptive resins (TH-1-TH-15). In the whole animal experiment, the hotplate-induced pain mice model was established to observe the effect of the samples on pain threshold in mice; the acetic acid-induced writhing response mice model was built to observe the effect of the samples on the writhing response in mice; the mice dysmenorrheal model was established to observe the effect of the samples on the writhing response, and calcium ion (Ca2+) and nitric oxide (NO) levels in uterine tissue of mice. In the isolated uterus contraction experiment, the oxytocin-induced isolated uterus contraction mice model was established to observe the effect of the samples on the isolated uterus contraction index. HPLC-DAD method was adopted for the content determination of effect sites. According to the evaluation of the integration geological effect, beside TH-2 and TH-4, other three active fractions (TH-9, TH-10 and TH-11) extracted from Taohong Siwu Tang are the main effect sites. Their chemical components were analyzed and identified as monoterpene glycosides, phthalides, organic acids, etc. The effect sites of Taohong Siwu Tang on dysmenorrhea are TH-9, TH-10 and TH-11, which are 30% - 50% active fractions obtained from water-soluble small-molecular fractions by gradient elution using ethanol through macroporous absorption resin. Compared with TH-10 and TH-11, TH-9 shows stronger effect, which may be related to the type and content of chemical components it contains.

  8. Kultuurmaastike ja elukeskkonna kujunemine ning hoidmine, sh poollooduslike koosluste taastamine ja hooldamine, mets, keskkond, loodushoid ja sood / Kaul Nurm

    Index Scriptorium Estoniae

    Nurm, Kaul

    2004-01-01

    Autori arvates tuleb maaelu uue arengukava väljatöötamisel keskmesse tõsta talupere ja sellised struktuurid, mis suudavad ning soovivad alalhoidlikke tootmisviise rakendada, aidates nii oma tegevusega kaasa puhta ja mitmekesise looduse kujunemisele, säilimisele

  9. Noorte olukord tööturul enne kriisi, kriisi ajal ning pärast kriisi / Siim Krusell

    Index Scriptorium Estoniae

    Krusell, Siim

    2015-01-01

    Noorte hõive, töötuse ja ametialase struktuuri analüüsi fookuses on haridust kolmandal tasemel omandavate noorte töötamine ning selle lõpetanute puhul hariduse ja tööl seatavate ülesannete kooskõla puudumine

  10. 22. ja 23. II esitatakse Tallinnas Kanuti Gildi saalis ning 25. ja 26. II Tartu Sadamateatris tantsulavastust "Myrrh and Cinnamon"

    Index Scriptorium Estoniae

    2005-01-01

    Koreograafideks on G. Welzman ja R. Haver ning selles kasutatakse nelja eesti helilooja A. Pärdi, M.-M. Lille, L. Sumera ja E.-S. Tüüri muusikat. Eesti gastrollidel esitab muusikat NYYD Ensemble. Lisaks eesti muusikutele on laval ka P. Pärenson

  11. "Rohgem ei tiija mina teile kirjuda." Kirjavormelid ning peresuhete kajastused Jakob Ploomi sõjakirjades / Andreas Kalkun

    Index Scriptorium Estoniae

    Kalkun, Andreas, 1977-

    2015-01-01

    Sõjaaegse kirjakultuuri levimisest Võrumaalt pärit nekrut Jakob Ploomi 26 isikliku kirja põhjal, millest näeb, mismoodi paistis Suur sõda rohujuuretasandilt ning seda, mismoodi talupojad jõudsid sõja poolt peale sunnitud vajadusest tingituna suulisest maailmast kirjakultuuri

  12. Rahvuslus, multikultuurilisus ja liberaalne lähenemine enamuse-vähemuse suhetes ning meedias / Ragne Kõuts

    Index Scriptorium Estoniae

    Kõuts, Ragne, 1977-

    2004-01-01

    Rahvussuhteid legitimeerivate ideestike teoreetilisest käsitlusest ning nende ideestike esinemisest Eesti avalikus arvamuses. Allikana on kasutatud 1999.-2002. a. korraldatud uuringu "Integratsiooniprotsesside meediamonitooring" käigus kogutud materjali. Tabel: Riikluse tõlgendusmallide põhielemendid Eesti ajakirjanduses

  13. Evolution of the Orszag-Tang vortex system in a compressible medium. II - Supersonic flow

    Science.gov (United States)

    Picone, J. Michael; Dahlburg, Russell B.

    1991-01-01

    A study is presented on the effect of embedded supersonic flows and the resulting emerging shock waves on phenomena associated with MHD turbulence, including reconnection, the formation of current sheets and vortex structures, and the evolution of spatial and temporal correlations among physical variables. A two-dimensional model problem, the Orszag-Tang (1979) vortex system, is chosen, which involves decay from nonrandom initial conditions. The system is doubly periodic, and the initial conditions consist of single-mode solenoidal velocity and magnetic fields, each containing X points and O points. The initial mass density is flat, and the initial pressure fluctuations are incompressible, balancing the local forces for a magnetofluid of unit mass density. Results on the evolution of the local structure of the flow field, the global properties of the system, and spectral correlations are presented. The important dynamical properties and observational consequences of embedded supersonic regions and emerging shocks in the Orszag-Tang model of an MHD system undergoing reconnection are discussed. Conclusions are drawn regarding the effects of local supersonic regions on MHD turbulence.

  14. Uus Euroopa pärimismäärus ning selle koht Eesti rahvusvahelises eraõiguses ja rahvusvahelises tsiviil(kohtu)menetluses / Eve Põtter, Maarja Torga

    Index Scriptorium Estoniae

    Põtter, Eve

    2013-01-01

    Ülevaade Euroopa pärimismääruse (EL 650/2012) kohaldamisalast ning määruses sisalduvast regulatsioonist. Määruse vahekord Eesti riigisisese õiguse ning Eesti rahvusvaheliste lepingutega, eelkõige nn kolmandate riikidega sõlmitud õigusabilepingutega

  15. [The affinity between Le family of Tong Ren Tang and acu-moxibustion as viewed from Mian xue tang zhen jiu ji cheng (Mian Xuetang's Synthetic Work of Acu-moxibustion)].

    Science.gov (United States)

    Huang, L X

    2017-11-28

    This compilation process of Mian xue tang zhen jiu ji cheng ( Mian Xuetang ' s Synthetic Work of Acu - moxibustion )was quite mysterious, the book's advent coincidentally met with several major historical events which made its value of decoding its historical functions far beyond its academic value. The editor of this book is Le Xianyang, the founder of Tong Ren Tang. While compiling this book, he also made a replica of Ming-Dynasty's Zhengtong bronze statue. More than 200 years later, Le Jingyu, the 12th generation of the Le family revised Ming Tang Tu inherited from his ancestors and engraved Ming Tang Tu on the stone for its standardization. This great achievement of Le family was no less than the recasting of the Tiansheng bronze statue and the reengraving Tong ren shu xue zhen jiu tu jing ( Illustrated Manual of Acupuncture Points of the Bronze Figure ) by support of state power for building the Beijing Imperial Hospital in the eighth year of the Zhengtong reign (1443).

  16. [Effect and mechanism of Mahuang Tang against influenza A/H1N1 virus in vitro].

    Science.gov (United States)

    Wei, Wen-Yang; Wan, Hai-Tong; Yu, Li; Lu, Yi-Yu; He, Yu

    2018-02-01

    To study the effect and underlying mechanism of Mahuang Tang against influenza A virus in vitro , the influenza virus-infected Madin-Darby canine kidney(MDCK) cells were used as the carrier in this study to detect the median tissue culture-infective dose(TCID₅₀) of influenza A virus strains(A/PR8/34) on MDCK cells with cytopathic effect(CPE) assay. Blocking influenza virus invading host cells and anti-influenza virus biosynthesis were used as two different administration methods, and then the methyl thiazolyl tetrazolium(MTT) assay was utilized to determine the antiviral effective rate(ER), median efficacious concentration(EC₅₀) and therapeutic index(TI) of Mahuang Tang. The quantitative Real-time polymerase chain reaction(RT-PCR) was used to measure virus load and the mRNA expression levels of TLR4, TLR7, MyD88 and TRAF6 in MDCK cells at 24, 48 h after the treatment. The experiment results indicated that TCID₅₀ of A/PR8/34 for MDCK cells was 1×10-4.32/mL. The EC₅₀ values of two different treatment methods were 4.92,1.59 g·L⁻¹ respectively, the TI values were 12.53, 38.78 respectively, and when the concentration of Mahuang Tang was 5.00 g·L⁻¹, ER values were 50.21%, 98.41% respectively, showing that Mahuang Tang can block influenza virus into the host cells and significantly inhibit their biosynthesis. Meanwhile, as compared with the virus group, the virus load was significantly inhibited in Mahuang Tang groups, and Mahuang Tang high and middle doses had the significant effect on decreasing the mRNA expression of TLR4, TLR7,MyD88 and TRAF6 at 24, 48 h after the treatment. It can be demonstrated that the mechanisms of Mahuang Tang against influenza A virus are related to the inhibition of influenza virus replication and the mRNA expression of correlative genes in TLR4 and TLR7 signaling pathways. Copyright© by the Chinese Pharmaceutical Association.

  17. Efficacy and Safety of Sipjeondaebo-Tang for Anorexia in Patients with Cancer: A Pilot, Randomized, Double-Blind, Placebo-Controlled Trial.

    Science.gov (United States)

    Cheon, Chunhoo; Yoo, Jeong-Eun; Yoo, Hwa-Seung; Cho, Chong-Kwan; Kang, Sohyeon; Kim, Mia; Jang, Bo-Hyoung; Shin, Yong-Cheol; Ko, Seong-Gyu

    2017-01-01

    Anorexia occurs in about half of cancer patients and is associated with high mortality rate. However, safe and long-term use of anorexia treatment is still an unmet need. The purpose of the present study was to examine the feasibility of Sipjeondaebo-tang (Juzen-taiho-to, Shi-Quan-Da-Bu-Tang) for cancer-related anorexia. A total of 32 participants with cancer anorexia were randomized to either Sipjeondaebo-tang group or placebo group. Participants were given 3 g of Sipjeondaebo-tang or placebo 3 times a day for 4 weeks. The primary outcome was a change in the Anorexia/Cachexia Subscale of Functional Assessment of Anorexia/Cachexia Therapy (FAACT). The secondary outcomes included Visual Analogue Scale (VAS) of anorexia, FAACT scale, and laboratory tests. Anorexia and quality of life measured by FAACT and VAS were improved after 4 weeks of Sipjeondaebo-tang treatment. However, there was no significant difference between changes of Sipjeondaebo-tang group and placebo group. Sipjeondaebo-tang appears to have potential benefit for anorexia management in patients with cancer. Further large-scale studies are needed to ensure the efficacy. This trial is registered with ClinicalTrials.gov NCT02468141.

  18. Huangqin-Tang and Ingredients in Modulating the Pathogenesis of Ulcerative Colitis.

    Science.gov (United States)

    Wang, Chunyan; Tang, Xudong; Zhang, Li

    2017-01-01

    Ulcerative colitis (UC) is the most common inflammatory bowel disease worldwide. Current therapies in UC cause limitations, and herb medicine provides an important choice for UC treatment. Huangqin-Tang (HQT) is a well-known classical traditional Chinese herbal formula and has been used in China for thousands of years. A large number of pharmacological studies demonstrated HQT and its ingredients to be effective in treating UC. Though the therapeutic effect has been evaluated, comprehensive up-to-date reviews in this field are not yet available. Here we aim to review our current understanding of HQT and its ingredients in treating UC and how the agents modulate the main pathogenesis of the disease, including the intestinal environment, immune imbalance, inflammatory pathways, and oxidative stress. The summary on this issue may provide better understanding of HQT and its ingredients in treating UC and possibly help in promoting its clinical application.

  19. Alteration of radiation-induced hematotoxicity by Bu-Zhong-Yi-Qi-Tang in mouse

    International Nuclear Information System (INIS)

    Jang, Jong Sik; Kim, Sung Ho

    2008-01-01

    The purpose of this study reported here was to investigate the ability of Bu-Zhong-Yi-Qi-Tang (BZYQT), known to elevate hematopoietic functions, to protect mice undergoing treatment with whole body single gamma-irradiation. BZYQT was given (25 mg/kg B.W.) intraperitoneally at 36 and 12 hours before irradiation and 30 minute and 24 hours after irradiation. Recovery of neutrophil and lymphocyte counts was significantly stimulated by extract of BZYQT. Stimulated recovery by the extract from the BZYQT was also observed in thrombocytes. However, the anti-radiation effect of erythrocyte, hemoglobin and hematocrit was not as significant as that of leukocyte. Further studies are needed to better characterize the protective nature of BZYQT extract and its ingredients

  20. Alteration of radiation-induced hematotoxicity by Bu-Zhong-Yi-Qi-Tang in mouse

    Energy Technology Data Exchange (ETDEWEB)

    Jang, Jong Sik [Kyungpook National University, Daegu (Korea, Republic of); Kim, Sung Ho [Chonnam National University, Gwangju (Korea, Republic of)

    2008-09-15

    The purpose of this study reported here was to investigate the ability of Bu-Zhong-Yi-Qi-Tang (BZYQT), known to elevate hematopoietic functions, to protect mice undergoing treatment with whole body single gamma-irradiation. BZYQT was given (25 mg/kg B.W.) intraperitoneally at 36 and 12 hours before irradiation and 30 minute and 24 hours after irradiation. Recovery of neutrophil and lymphocyte counts was significantly stimulated by extract of BZYQT. Stimulated recovery by the extract from the BZYQT was also observed in thrombocytes. However, the anti-radiation effect of erythrocyte, hemoglobin and hematocrit was not as significant as that of leukocyte. Further studies are needed to better characterize the protective nature of BZYQT extract and its ingredients.

  1. Effects of Sohamhyoong-Tang on Ovalbumin-Induced Allergic Reaction in BALB/c Mice

    Directory of Open Access Journals (Sweden)

    So Hyun Jo

    2016-01-01

    Full Text Available IgE-mediated mast cell degranulation and excessive Th2 cells activation are major features of various allergic diseases. Sohamhyoong-tang has been reported to have anti-inflammatory and antibacterial effects. In this study, we investigated the inhibitory effect of Sohamhyoong-tang extract (SHHTE on allergic symptoms and inflammatory responses in ovalbumin- (OVA- sensitized BALB/c mice. The mice were sensitized with OVA and alum at 2-week intervals and then orally given SHHTE for 13 days followed by intradermal OVA injection. Administration of SHHTE significantly reduced edema formation and inflammatory-cell infiltration in ear tissues. Total and OVA-specific IgEs as well as proinflammatory cytokine TNF-α and Th2-associated cytokine IL-4 levels were lower in the SHHTE-treated group than in the vehicle. SHHTE treatment significantly suppressed both mRNA and protein levels of IL-4 and IL-5 in OVA-stimulated splenocytes. SHHTE decreased Th1 (IFN-γ and Th17 (IL-17a cytokine mRNA expression but increased Treg cytokines (IL-10 and TGF-β1. Moreover, SHHTE significantly inhibited degranulation of RBL-2H3 cell line in a dose-dependent manner. Thus, SHHTE efficiently inhibited the allergic symptoms in an OVA-sensitized mouse model and its action may correlate with the suppression of IgE production by increasing IL-10 and TGF-β1, which can limit the function of other T helper cells and prevent the release of inflammatory mediators from mast cells. These results suggest that SHHTE could be a therapeutic agent for treating various allergic diseases.

  2. Evaluation of root-knot nematode disease control and plant growth promotion potential of biofertilizer Ning shield on Trichosanthes kirilowii in the field.

    Science.gov (United States)

    Jiang, Chun-Hao; Xie, Ping; Li, Ke; Xie, Yue-Sheng; Chen, Liu-Jun; Wang, Jin-Suo; Xu, Quan; Guo, Jian-Hua

    Biofertilizer Ning shield was composed of different strains of plant growth promotion bacteria. In this study, the plant growth promotion and root-knot nematode disease control potential on Trichosanthes kirilowii in the field were evaluated. The application of Ning shield significantly reduced the diseases severity caused by Meloidogyne incognita, the biocontrol efficacy could reached up to 51.08%. Ning shield could also promote the growth of T. kirilowii in the field by increasing seedling emergence, height and the root weight. The results showed that the Ning shield could enhance the production yield up to 36.26%. Ning shield could also promote the plant growth by increasing the contents of available nitrogen, phosphorus, potassium and organic matter, and increasing the contents of leaf chlorophyll and carotenoid pigment. Moreover, Ning shield could efficiently enhance the medicinal compositions of Trichosanthes, referring to the polysaccharides and trichosanthin. Therefore, Ning shield is a promising biofertilizer, which can offer beneficial effects to T. kirilowii growers, including the plant growth promotion, the biological control of root-knot disease and enhancement of the yield and the medicinal quality. Copyright © 2017 Sociedade Brasileira de Microbiologia. Published by Elsevier Editora Ltda. All rights reserved.

  3. Lipid-lowering and antioxidant activities of Jiang-Zhi-Ning in Traditional Chinese Medicine.

    Science.gov (United States)

    Chen, Jianxin; Zhao, Huihui; Yang, Ying; Liu, Bing; Ni, Jian; Wang, Wei

    2011-04-12

    Jiang-Zhi-Ning (JZN) is composed of four Chinese herbs, i.e., Fleeceflower Root, Fructus Crataegi, Folium Nelumbinis and Semen Cassiae. It was used to strengthen blood circulation of coronary artery, arrhythmia and hyperlipidemia. The main objective of this paper is to evaluate lipid-lowering and antioxidant activities of extract and effective fraction of JZN by using in vitro experiments on hyperlipidemic rats. Moreover, in vivo experiments on cells were performed to investigate lipid-lowering and antioxidant activities of effective fraction and active constituents of JZN. Wistar rats with high fat diet-induced hyperlipidemia were used as in vitro models to study biological effects of lipid-lowering and antioxidant activities of extract and effective fraction of JZN. Serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), Coronary Index and Atherogenic Index were investigated to evaluate lipid-lowering effects of extract and effective fraction of JZN. Serum total nitric oxide synthase (NOS), nitric oxide (NO), endothelin-1 (ET-1), malondialdehyde (MDA), superoxide dismutase (SOD) and total antioxidant capacity (T-AOC) were detected to measure antioxidant effects of extract and effective fraction of JZN. Furthermore, oxidized low-density lipoprotein (Ox-LDL) injured human umbilical vein endothelial cell (HUVEC) model was employed as in vivo experiment to study lipid-lowering and antioxidant effects of effective fraction and active constituents of JZN. NO, ET-1, MDA SOD and T-AOC in HUVECs or culture media were investigated to evaluate antioxidant activity of effective fraction and active constituents of JZN. Using human hepatoma cell line Bel-7402, reverse transcription polymerase chain reaction (RT-PCR) technology was performed to investigate cholesterol metabolism effects of effective fraction and active constituents of JZN. Expressions of low density lipoprotein receptor (LDL

  4. Concentration serum cortisol data from experimental studies of Yellow Tang fish (Zebrasoma flavescens) from 2011-07-10 to 2011-11-10 (NODC Accession 0125562)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This archival package contains laboratory experiment data that were collected to examine the effects of venting and decompression on Yellow Tang (Zebrasoma...

  5. Højintens intervaltræning inducerer moderat forbedring i cirkulerende diabetes-relaterede inflammatoriske cytokiner

    DEFF Research Database (Denmark)

    Bjerre, Mette; Madsen, Søren Møller; Jeppesen, Per Bendix

    2017-01-01

    Det er alment kendt, at motion forbedrer den metaboliske tilstand og mindsker risikoen for udvikling af præ-diabetes til type 2-diabetes. En væsentlig gevinst af regelmæssig motion menes at være via systemiske anti-inflammatoriske effekter, der formentlig skyldes en reduktion af fedtvævet. Hver g...... afklaret. Vi ønskede derfor at undersøge påvirkningen af højintens intervaltræning (HIIT) på cirkulerende inflammatoriske cytokiner hos patienter med type 2-diabetes.1-3...

  6. Pääsküla sõjaväeobjekti jääkreostus ning piirkonna edasise kasutamise perspektiivid / Triin Uudeväli, Anto Raukas

    Index Scriptorium Estoniae

    Uudeväli, Triin

    2004-01-01

    Pääskülas asunud NL-i raketijuhtimisekeskuse ja sideväeosa poolt tekitatud keskkonnareostuse hindamisest, likvideerimisest ning ettepanekutest territooriumi edasiseks kasutamiseks. Kaart. Skeem. Fotod

  7. Pretreatment with Shuanghe-Tang Extract Attenuates Postischemic Brain Injury and Edema in a Mouse Model of Stroke: An Analysis of Medicinal Herbs Listed in Dongui Bogam

    Directory of Open Access Journals (Sweden)

    Min Jae Kim

    2018-01-01

    Full Text Available Aim. Although stroke is among the leading causes of death and long-term disability, there are few effective treatments for limiting the severity of neurological sequelae. We evaluated the effects of 29 medicinal herbs listed in the Pung chapter of the 17th century Korean medical text Dongui Bogam on stroke symptoms in a mouse model of cerebral ischemia. Methods. Focal cerebral ischemia was induced via photothrombosis. Infarct volume, brain edema, and neurological deficits were evaluated. Immunofluorescence staining for tight junction proteins and aquaporin 4 (AQP4 was performed following ischemic injury. Results. Based on our initial findings, we examined the effects of two prescriptions in which the candidate herbs comprised more than 60% of the total formula: Shuanghe-tang and Zengsunsiwu-tang. Pretreatment with Shuanghe-tang significantly reduced infarct volume, decreased blood-brain barrier (BBB breakdown, attenuated edema, and improved neurological and motor functions in a dose-dependent manner (30, 100, and 300 mg/kg, while no such effects were observed in mice pretreated with Zengsunsiwu-tang. Immunohistochemical analysis revealed significant increases in ipsilateral occludin and zonula occludens 1 (ZO-1 expression in Shuanghe-tang-pretreated mice, as well as increased AQP4 immunofluorescence. Conclusions. These results indicate that Shuanghe-tang may protect against brain injury and promote recovery of neurological function following ischemia.

  8. Suan Zao Ren Tang as an Original Treatment for Sleep Difficulty in Climacteric Women: A Prospective Clinical Observation

    OpenAIRE

    Chia-Hao Yeh; Christof K. Arnold; Yen-Hui Chen; Jung-Nein Lai

    2011-01-01

    Little scientific evidence supports the efficacy of herbal medicines in the treatment of women with sleep difficulty during the climacteric period. The purpose of this study is to evaluate the efficacy and safety of Suan Zao Ren Tang (SZRT) in reducing the impact of sleep disturbance on climacteric women, as measured by Pittsburg sleep quality index (PSQI) and the World Health Organization quality of life (WHOQOL). Sixty-seven climacteric women with sleep difficulty intending to treat receive...

  9. Sipjeondaebo-tang in patients with cancer with anorexia: a protocol for a pilot, randomised, controlled trial.

    Science.gov (United States)

    Cheon, Chunhoo; Park, Sunju; Park, Yu Lee; Huang, Ching-Wen; Ko, Youme; Jang, Bo-Hyoung; Shin, Yong-Cheol; Ko, Seong-Gyu

    2016-05-12

    Cancer-related anorexia is the loss of appetite or desire to eat in patients with cancer. Although treatments for cancer-related anorexia do exist, patients have sought complementary and alternative medicine including herbal remedies, due to safety concerns. Sipjeondaebo-tang is one among other popular herbal medicines that are beneficial to management of anorexia in Korea. The purpose of this study is to examine the feasibility for a full randomised clinical trial of Sipjeondaebo-tang for cancer-related anorexia. This study is a randomised, double-blinded and placebo-controlled trial of Sipjeondaebo-tang. For the study, 40 patients with cancer, aged 20-80 years, who reported anorexia, will be recruited. The participants will receive either 3 g of Sipjeondaebo-tang or a placebo, 3 times a day for 4 weeks. The primary end point is a change in the anorexia/cachexia subscale (A/CS) of Functional Assessment of Anorexia/Cachexia Therapy (FAACT). The secondary end points include changes in the visual analogue scale (VAS) of appetite, cortisol and ghrelin. The outcomes will be measured on every visit. Each participant will visit once a week during 4 weeks. The present study has been approved by the Institutional Review Board of the Dunsan Korean Medicine Hospital of Daejeon University (reference DJDSKH-15-03-2 (V.2.0)). The results will be disseminated in a peer-reviewed journal and scientific conference. NCT02468141; Pre-results. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  10. Inhibitory Effects of Daiokanzoto (Da-Huang-Gan-Cao-Tang on P-Glycoprotein

    Directory of Open Access Journals (Sweden)

    Yuka Watanabe

    2012-01-01

    Full Text Available We have studied the effects of various Kampo medicines on P-glycoprotein (P-gp, a drug transporter, in vitro. The present study focused on Daiokanzoto (Da-Huang-Gan-Cao-Tang, which shows the most potent inhibitory effects on P-gp among the 50 Kampo medicines studied, and investigated the P-gp inhibitory effects of Daiokanzoto herbal ingredients (rhubarb and licorice root and their components by an ATPase assay using human P-gp membrane. Both rhubarb and licorice root significantly inhibited ATPase activity, and the effects of rhubarb were more potent than those of licorice root. The content of rhubarb in Daiokanzoto is double that in licorice root, and the inhibition patterns of Daiokanzoto and rhubarb involve both competitive and noncompetitive inhibition, suggesting that the inhibitory effects of Daiokanzoto are mainly due to rhubarb. Concerning the components of rhubarb, concentration-dependent inhibitory effects were observed for (−-catechin gallate, (−-epicatechin gallate, and (−-epigallocatechin gallate. In conclusion, rhubarb may cause changes in the drug dispositions of P-gp substrates through the inhibition of P-gp. It appears that attention should be given to the interactions between these drugs and Kampo medicines containing rhubarb as an herbal ingredient.

  11. Anti-Inflammatory Effects of the Chinese Herbal Formula Sini Tang in Myocardial Infarction Rats

    Directory of Open Access Journals (Sweden)

    Jiangang Liu

    2014-01-01

    Full Text Available The aim of this study was to evaluate the anti-inflammatory profiling of the Chinese herbal formula Sini Tang (SNT in myocardial infarction (MI rats. SNT, a decoction consisting of four herbs: Aconitum carmichaelii, Cinnamomum cassia, Zingiber officinale, and Glycyrrhiza uralensis, was characterized as a remedy to treat syndromes corresponding to heart failure and MI in China. Potential biomarkers, which reflect the extent of myocardial necrosis and correlate with cardiac outcomes following MI, such as atrial natriuretic peptide (ANP, high sensitivity C-reactive protein (hs-CRP, and proinflammatory cytokines such as tumor necrosis factor-α, interleukin-6, and interleukin-1β (TNF-α, IL-6, and IL-1β were determined in plasma, serum, and in myocardial tissue of MI rats after treatment with SNT. Our data indicate that SNT decreased significantly the levels of hs-CRP, TNF-α, IL-6, and IL-1β in MI rats. SNT decreased the expression of ANP levels in plasma and increased the vascular active marker nitric oxide, which limits vascular inflammation. In addition, SNT could decrease the expression of endothelin-1 levels in rat plasma post-MI. Our data suggest that the Chinese herbal formula SNT has the potential to improve cardiac function after MI. SNT may be a candidate for treating MI and its associated inflammatory responses.

  12. Genoprotective effect of the Chinese herbal decoction xiao jian zhong tang.

    Science.gov (United States)

    Szeto, Yim-Tong; Cheng, Ngok-Fung; Pak, Sok-Cheon; Kalle, Wouter

    2013-03-01

    The Chinese herbal decoction formula Xiao Jian Zhong Tang (XJZT) is one of the classic formulas from the classic traditional Chinese medicine (TCM). Previous studies on XJZT found that it is effective for treating peptic ulcer, irritable bowel syndrome, functional gastroenteritis and similar psychosomatic disorders of the digestive organs. It has also been shown that all the herbs used in XJZT contain antioxidants. In this study, we investigated the in vitro DNA protection effect of the individual herb extracts and the whole formula. Water extract of the herbs and XJZT were used to pre-treat human lymphocytes. The lymphocytes were then exposed to hydrogen peroxide. The in vitro DNA protection effect of the herbs was investigated by comet assay. No DNA protective effect (P < 0.05) was found for individual herb extracts, but XJZT showed protection of human lymphocytic DNA upon oxidative stress (P < 0.05). The in vitro DNA protection effect of XJZT was conferred by the synergistic effect of the herbs, while the individual herbs had no such effect.

  13. Huangqi Jianzhong Tang for Treatment of Chronic Gastritis: A Systematic Review of Randomized Clinical Trials

    Science.gov (United States)

    Wei, Yue; Ma, Li-Xin; Yin, Sheng-Jun; An, Jing; Wei, Qi; Yang, Jin-Xiang

    2015-01-01

    To assess the clinical effects and safety of Huangqi Jianzhong Tang (HQJZ) for the treatment of chronic gastritis (CG), three English databases and four Chinese databases were searched through the inception to January 2015. In randomized controlled trials (RCTs) comparing HQJZ with placebo, no intervention and western medicine were included. A total of 9 RCTs involving 979 participants were identified. The methodological quality of the included trials was generally poor. Meta-analyses demonstrated that HQJZ plus conventional medicine was more effective in improving overall gastroscopy outcome than western medicine alone for treatment of chronic superficial gastritis with the pooling result of overall improvement [OR 3.78 (1.29,11.06), P = 0.02]. In addition, the combination of HQJZ with antibiotics has higher overall effect rate than antibiotics alone for the treatment of CG [OR 2.60 (1.49,4.54), P = 0.0007]. There were no serious adverse events reported in both the intervention and controlled groups. HQJZ has the potential of improvement of the patients' gastroscopy outcomes, Helicobacter pylori clearance rate, traditional Chinese Medicine syndromes, and overall effect rate alone or in combination use with conventional western medicine for chronic atrophic gastritis. However, due to poor methodological quality, the beneficial effect and safeties of HQJZ for CG could not be confirmed. PMID:26819622

  14. Immune checkpoint blockade therapy: The 2014 Tang prize in biopharmaceutical science

    Directory of Open Access Journals (Sweden)

    Ya-Shan Chen

    2015-02-01

    Full Text Available The first Tang Prize for Biopharmaceutical Science has been awarded to Prof. James P. Allison and Prof. Tasuku Honjo for their contributions leading to an entirely new way to treat cancer by blocking the molecules cytotoxic T lymphocyte-associated antigen 4 (CTLA-4 and programmed cell death protein 1 (PD-1 that turn off immune response. The treatment, called "immune checkpoint blockade therapy," has opened a new therapeutic era. Here the discoveries of the immune checkpoints and how they contribute to the maintenance of self-tolerance, as well as how to protect tissues from the excess immune responses causing damage are reviewed. The efforts made by Prof. Allison and Prof. Honjo for developing the most promising approaches to activate therapeutic antitumor immunity are also summarized. Since these certain immune checkpoint pathways appear to be one of the major mechanisms resulting in immune escape of tumors, the presence of anti-CTLA-4 and/or anti-PD-1 should contribute to removal of the inhibition signals for T cell activation. Subsequently, it will enhance specific T cell activation and, therefore, strengthen antitumor immunity.

  15. Therapeutic potential of Wenshen Xiaozheng tang, a traditional Chinese medicine prescription, for treating endometriosis.

    Science.gov (United States)

    Zhang, Zhenzhen; Hu, Chunping; Tang, Weiwei; Gui, Tao; Qian, Ruyun; Xing, Yuxia; Cao, Peng; Wan, Guiping

    2013-10-01

    The objective of this study is to investigate the effect of Wenshen Xiaozheng Tang (WXT) on the development of endometriosis in a rat model. Sprague-Dawley rats in which endometriotic implants were induced were divided randomly into 3 groups. The rats in the low-dose and high-dose WXT groups were administered WXT 8.57 and 17.14 g/kg/d, respectively. The rats in the control groups received an equal volume of dissolvent, as did the sham-operated rats. After treatment for 4 weeks, WXT significantly decreased the mean lesion size as well as the peritoneal fluid and serum levels of tumor necrosis factor α and interleukin 1β. Cyclooxygenase-2, matrix metalloproteinase 9, plasminogen activator inhibitor 1, and intercellular adhesion molecule 1 messenger RNA (mRNA) levels were downregulated, and the mRNA expression of tissue inhibitor of metalloproteinase 1 was upregulated in the endometriotic lesions of WXT versus control group. Our data suggested that WXT may suppress the development of endometriosis by inhibiting the production of proinflammatory cytokines and regulating the expression of invasion-related genes in the endometriotic lesions.

  16. Novel pharmacokinetic studies of the Chinese formula Huang-Lian-Jie-Du-Tang in MCAO rats.

    Science.gov (United States)

    Zhu, Huaxu; Qian, Zhilei; He, Feng; Liu, Mengzhu; Pan, Linmei; Zhang, Qichun; Tang, Yuping

    2013-07-15

    Our previous studies showed that after oral administration of an Huang-Lian-Jie-Du-Tang (HLJDT) decoction, there is a higher concentration of the pure components, berberine, baicalin and gardenoside in the plasma of Middle cerebral artery occlusion (MCAO) rats than in sham-operated rats, The aim of the present study was to determine whether these components could be reliably measured in MCAO rat tissues. First, the plasma concentration-time profiles of berberine, palmatine, baicalin, baicalein and gardenoside were characterised in MCAO rats after oral administration of the aqueous extract of HLJDT. Subsequently, liver, lung and kidney tissues were obtained from sudden death MCAO rats in the absorption phase (0.25 h), the distribution phase (1.0 h) and the elimination phase (8.0 h) after administration of the HLJDT aqueous extract. An HPLC method was developed and validated for the determination of the distribution characteristics of berberine, palmatine, baicalin, baicalein and gardenoside simultaneously from the above-mentioned rat tissues. The results indicated that berberine, palmatine, baicalin and baicalein distributed rapidly and accumulated at high levels in the lung, while gardenoside distributed widely in the lung and the kidney. To the best of our knowledge, this is the first report to describe the distribution of the active ingredients derived from HLJDT in MCAO rat tissues. The tissue distribution results provide a biopharmaceutical basis for the design of the clinic application of HLJDT in cerebrovascular disease. Copyright © 2012 Elsevier GmbH. All rights reserved.

  17. Investigation of Kelvin wave periods during Hai-Tang typhoon using Empirical Mode Decomposition

    Science.gov (United States)

    Kishore, P.; Jayalakshmi, J.; Lin, Pay-Liam; Velicogna, Isabella; Sutterley, Tyler C.; Ciracì, Enrico; Mohajerani, Yara; Kumar, S. Balaji

    2017-11-01

    Equatorial Kelvin waves (KWs) are fundamental components of the tropical climate system. In this study, we investigate Kelvin waves (KWs) during the Hai-Tang typhoon of 2005 using Empirical Mode Decomposition (EMD) of regional precipitation, zonal and meridional winds. For the analysis, we use daily precipitation datasets from the Global Precipitation Climatology Project (GPCP) and wind datasets from the European Centre for Medium-Range Weather Forecasts (ECMWF) Interim Re-analysis (ERA-Interim). As an additional measurement, we use in-situ precipitation datasets from rain-gauges over the Taiwan region. The maximum accumulated precipitation was approximately 2400 mm during the period July 17-21, 2005 over the southwestern region of Taiwan. The spectral analysis using the wind speed at 950 hPa found in the 2nd, 3rd, and 4th intrinsic mode functions (IMFs) reveals prevailing Kelvin wave periods of ∼3 days, ∼4-6 days, and ∼6-10 days, respectively. From our analysis of precipitation datasets, we found the Kelvin waves oscillated with periods between ∼8 and 20 days.

  18. Antidepressant-like effects of Gan-Mai-Dazao-Tang via monoamine regulatory pathways on forced swimming test in rats.

    Science.gov (United States)

    Huang, Hsiang-Ling; Lim, Swee-Ling; Lu, Kuan-Hung; Sheen, Lee-Yan

    2018-01-01

    Depression is a highly prevalent and recurrent mental disorder that impacts all aspects of human life. Undesirable effects of the antidepressant drugs led to the development of complementary and alternative therapies. Gan-Mai-Da-Zao-Tang (, gān mài dà zǎo tang) is a traditional herbal formula commonly used for the treatment of depression, but lack of scientific proof on its mechanism. It consisted of Glycyrrhiza uralensis Fisch. (licorice), Triticum aestivum L. (wheat) and Zizphus jujuba Mill. (jujube). The objective of this study is to investigate the antidepressant effects of Gan-Mai-Dazao-Tang and its ingredients in rats exposed to forced swimming test (FST). The 72 of male Nerl: Wistar rats (8 weeks old) were randomized into control (10 mL/kg bw H 2 O), licorice (0.4 g/kg bw), wheat (1.6 g/kg bw), jujube (0.5 g/kg bw), Gan-Mai-Da-Zao-Tang (2.5 g/kg bw of licorice: wheat: jujube in ratio of 5:20:6) and Prozac (18 mg/kg bw) groups. Samples were administered by oral gavage for 21 days. FST was performed on 21st day, with 15 min for pretest followed by 5 min for real test. Then, the animals were sacrificed and brain tissues were collected for monoamines analyses. The Gan-Mai-Da-Zao-Tang (LWJ) showed significantly down-regulation of immobility time, 3,4-dihydroxyphenylacetic acid (DOPAC) and DOPAC/dopamine (DA) turnover rates, and also enhanced the concentration of serotonin (5-HT) and DA in brain tissues, as compared with the control. The LWJ stated the potent antidepressant-like effect by modulating these monoamines concentration, while the licorice, wheat and jujube did not reported significant results as compared with control group. The positive control (Prozac) was noted with significantly reduction in body weight and appetite. In conclusion, the antidepressant-like effects of LWJ might be mediated by the regulation of monoamine neurotransmitters. Thus, it could beneficial in depression treatment as a complementary approach.

  19. Antidepressant-like effects of Gan-Mai-Dazao-Tang via monoamine regulatory pathways on forced swimming test in rats

    Directory of Open Access Journals (Sweden)

    Hsiang-Ling Huang

    2018-01-01

    Full Text Available Depression is a highly prevalent and recurrent mental disorder that impacts all aspects of human life. Undesirable effects of the antidepressant drugs led to the development of complementary and alternative therapies. Gan-Mai-Da-Zao-Tang (甘麥大棗湯, gān mài dà zǎo tang is a traditional herbal formula commonly used for the treatment of depression, but lack of scientific proof on its mechanism. It consisted of Glycyrrhiza uralensis Fisch. (licorice, Triticum aestivum L. (wheat and Zizphus jujuba Mill. (jujube. The objective of this study is to investigate the antidepressant effects of Gan-Mai-Dazao-Tang and its ingredients in rats exposed to forced swimming test (FST. The 72 of male Nerl: Wistar rats (8 weeks old were randomized into control (10 mL/kg bw H2O, licorice (0.4 g/kg bw, wheat (1.6 g/kg bw, jujube (0.5 g/kg bw, Gan-Mai-Da-Zao-Tang (2.5 g/kg bw of licorice: wheat: jujube in ratio of 5:20:6 and Prozac (18 mg/kg bw groups. Samples were administered by oral gavage for 21 days. FST was performed on 21st day, with 15 min for pretest followed by 5 min for real test. Then, the animals were sacrificed and brain tissues were collected for monoamines analyses. The Gan-Mai-Da-Zao-Tang (LWJ showed significantly down-regulation of immobility time, 3,4-dihydroxyphenylacetic acid (DOPAC and DOPAC/dopamine (DA turnover rates, and also enhanced the concentration of serotonin (5-HT and DA in brain tissues, as compared with the control. The LWJ stated the potent antidepressant-like effect by modulating these monoamines concentration, while the licorice, wheat and jujube did not reported significant results as compared with control group. The positive control (Prozac was noted with significantly reduction in body weight and appetite. In conclusion, the antidepressant-like effects of LWJ might be mediated by the regulation of monoamine neurotransmitters. Thus, it could beneficial in depression treatment as a complementary approach.

  20. Jian Nao Ning for Treatment of Memory Impairment in Patients with Mild or Moderate Multi-infarct Dementia

    Institute of Scientific and Technical Information of China (English)

    田金洲; 尹军祥; 刘峘; 杨承芝; 王永炎

    2002-01-01

    Forty patients with multi-infarct dementia (MID) were randomly assigned to the treatment group (25 cases) treated with Jian Nao Ning (健脑宁JNN) and the duxil control group (15 cases). Memory function were assessed at baseline and endpoint using memory subscales of a battery of New Psychometric Tests (Chinese version) including mini-mental state examination (MMSE), verbal memory, and non-verbal memory, etc. After treatment, the mean scores of verbal memory in the Hopkins Verbal Learning Test (P<0.05) and total memory scores of memory items (P<0.001) in JNN group increased significantly; and improvement in episodic memory function including story recall (immediate and delayed), delayed word recall, verbal learning and verbal recognition and visual recognition in the JNN group was better than that in the duxil control group, suggesting that JNN can obviously improve memory function for the patients with mild or moderate multi-infarct dementia.

  1. Hwangryun-Haedok-Tang Fermented with Lactobacillus casei Suppresses Ovariectomy-Induced Bone Loss

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    Ki-Shuk Shim

    2012-01-01

    Full Text Available Hwangryun-haedok-tang (HRT is the common recipe in traditional Asian medicine, and microbial fermentation is used for the conventional methods for processing traditional medicine. We investigated the inhibitory effect of the n-butanol fraction of HRT (HRT-BU and fHRT (fHRT-BU on the RANKL-induced osteoclastogenesis in bone-marrow-derived macrophages. mRNA expression of osteoclastogenesis-related genes were evaluated by real-time QPCR. The activation of signaling pathways was determined by western blot analysis. The marker compounds of HRT-BU and fHRT-BU were analyzed by HPLC. The inhibitory effect of HRT or fHRT on ovariectomy-induced bone loss were evaluated using OVX rats with orally administered HRT, fHRT (300, 1000 mg/kg, or its vehicle for 12 weeks. fHRT-BU significantly inhibited RANKL-induced osteoclastogenesis, and phosphorylation of p38, IKKα/β, and NF-κBp65 compared to HRT-BU. In addition, fHRT-BU also significantly inhibited the mRNA expression of Nfκb2, TNF-α, NFATc1, TRAP, ATPv0d2, and cathepsin K. Furthermore, administration of fHRT had a greater effect on the increase of BMD, and greater improved bone microstructure of the femora than that of HRT in ovariectomy rats. This study demonstrated that bacterial fermentation enhances the inhibitory effect of HRT on osteoclastogenesis and bone loss. These results suggest that fermented HRT might have the beneficial effects on bone disease by inhibiting osteoclastogenesis.

  2. THE IDENTIFICATION OF THE BINDING MEDIA IN THE TANG DYNASTY CHINESE WALL PAINTINGS BY USING Py-GC/MS AND GC/MS TECHNIQUES

    Directory of Open Access Journals (Sweden)

    Hong GUO

    2011-06-01

    Full Text Available The archaeological discoveries of Tang tomb murals in Xi’an, China brought to light unprecedented data for the study of the art of the Tang Dynasty (618-907 AD. The spectacular murals with their particular contents provided first-hand material for the study of Chinese history and the techniques of wall paintings during the Tang Dynasty. In order to gain a better understanding of the materials used and to preserve those paintings, pyrolysis-gas chromatography-mass spectrometry (Py-GC/MS and gas chromatography-mass spectrometry (GC/MS were applied for the characterization of the binding media in the paintings. The combination of these analytical techniques is an ideal methodology to identify binding media in unknown samples.

  3. [Effect of Zhenwu Tang on regulating of "AVP-V2R-AQP2" pathway in NRK-52E cells].

    Science.gov (United States)

    Zhou, Xiao-Jie; Bao, Yu-Ting; Chen, Hong-Shu; Xuan, Ling; Chen, Xue-Ming; Zhang, Jie-Ying; Yang, Yuan-Xiao; Li, Chang-Yu

    2018-02-01

    This study was aimed to investigate the effect and mechanism of Zhenwu Tang on AVP-V2R-AQP2 pathway in NRK-52E cells in vitro . Forty eight male SD rats were randomly divided into eight groups with 6 animals in each group. Distilled water or 22.68 g·kg⁻¹·d⁻¹ Zhenwu Tang(calculated by raw drug dosage meter) was given by gavage. Blood samples were collected by cardiac puncture, and the medicated serum was centrifuged from the blood by 3 000 r·min⁻¹. NRK-52E cells were treated with different medicated serum or dDAVP. The condition of cell proliferation was detected by RTCA. The distribution of V2R and AQP2 in cells were detected by immunofluorescence. The expression of V2R, PKA and AQP2 were detected by Western blot and AQP2 mRNA level was detected by real-time PCR. Results showed that the level of AQP2 mRNA( P Tang medicated serum for 24 h were significantly higher than that of normal rat serum group. And the expression level of V2R, p-AQP2 and AQP2( P Tang medicated serum could increase the expression level of V2R, PKA and AQP2 which exist in AVP-V2R-AQP2 pathway in NRK-52E, and there is synergistic effect between Zhenwu Tang medicated serum and dDAVP. So the pathway of AVP-V2R-AQP2 may be one of the mechanism for which Zhenwu Tang regulate balance of water transportation. Copyright© by the Chinese Pharmaceutical Association.

  4. Chromatographic isolation of nanoparticles from Ma-Xing-Shi-Gan-Tang decoction and their characterization.

    Science.gov (United States)

    Zhou, Jianwu; Gao, Guanzhen; Chu, Qiuping; Wang, Huiqin; Rao, Pingfan; Ke, Lijing

    2014-02-12

    The herbal decoction is a complex dispersion system containing solutes, colloid, aggregates, emulsions and precipitates. In which phase bioactive phytochemicals are dispersed determines their delivery, action and metabolism. This study took ephedrine, a well-studied and widely used phytochemical, as an example to elucidate its exact distribution in the phases of Ma-Xing-Shi-Gan-Tang decoction (MXSGT), which is an Ephedra sinica Stapf. containing traditional Chinese medicinal formula, and the biological meaning of this distribution correspondingly. It may provide an important update to the safety and efficacy assessment of the herbal decoction and its active phytochemicals. In this study, the decoction was fractionated with size-exclusion chromatography coupled with multi-angle laser light scattering detector. The morphology of fractionated nanoparticles was observed with AFM and SEM. The bioactivities of the decoction, the ephedrine alkaloids loaded NPs (prepared by chromatography isolation) and the synthetic ephedrine were assessed by cell proliferation tests using five cell lines, namely Caco-2, L-02, Hep-G2, NR-8383, and Hela-229. Nanoparticles with radii of gyration ranged from 50 to 150 nm were isolated, in spherical shape. Further analysis of nanoparticles on the subsequent reversed phase chromatography revealed that the majority of ephedrine (99.7%) and pseudoephedrine (95.5%) were associated with these nanoparticles, rather than dispersed freely in the real solution. The addition of both the herbal decoction and the separated ephedrine-loaded nanoparticles reserved higher cell viability/proliferation than that of the sole synthetic ephedrine among the Caco-2, L-02, Hep-G2, and NR-8383 cells. In contrast, the nanoparticles reduced the proliferating power of ephedrine on Hela-229 cells. In general, the ephedrine-loaded NPs conducted the intermediate influences on the cell viability, in either way. The colloidal nanoparticles were separated from the decoction

  5. Inimväärikust alandava kohtlemise kriteeriumid ning nende rakendamine kinnipidamistingimuste hindamisel. Euroopa Inimõiguste Kohtu ja Riigikohtu halduskolleegiumi seisukohad / Carolin Toomingas

    Index Scriptorium Estoniae

    Toomingas, Carolin

    2016-01-01

    Inimväärikusest, inimväärikust alandavast kohtlemisest ja karistamise keelust ning väärikuse alandamisest kui riigi vastu suunatud nõude alusest. Euroopa Inimõiguste Kohtu praktika ja Euroopa inimõiguste ja põhivabaduste kaitse konventsiooni tähtsusest Eesti kohtute töös. Sisaldab asjakohast kohtupraktikat

  6. Total Glucosides of Danggui Buxue Tang Attenuate BLM-Induced Pulmonary Fibrosis via Regulating Oxidative Stress by Inhibiting NOX4

    Science.gov (United States)

    Zhao, Ping; Zhou, Wen-Cheng; Li, De-Lin; Mo, Xiao-Ting; Xu, Liang; Li, Liu-Cheng; Cui, Wen-Hui; Gao, Jian

    2015-01-01

    Pulmonary fibrosis (PF) is a serious chronic lung disease with unknown pathogenesis. Researches have confirmed that oxidative stress which is regulated by NADPH oxidase-4 (NOX4), a main source of reactive oxygen species (ROS), is an important molecular mechanism underlying PF. Previous studies showed that total glucosides of Danggui Buxue Tang (DBTG), an extract from a classical traditional Chinese herbal formula, Danggui Buxue Tang (DBT), attenuated bleomycin-induced PF in rats. However, the mechanisms of DBTG are still not clear. We hypothesize that DBTG attenuates PF through regulating the level of oxidative stress by inhibiting NOX4. And we found that fibrosis indexes hydroxyproline (HYP) and type I collagen (Col-I) were lower in DBTG groups compared with the model group. In addition, the expression of transforming growth factor-β1 (TGF-β1) and expression of alpha smooth muscle actin (α-SMA) were also much more decreased than the model group. For oxidative stress indicators, DBTG blunted the decrease of superoxide dismutase (SOD) activity, total antioxidant capacity (T-AOC), and the increase in malondialdehyde (MDA), 8-iso-prostaglandin in lung homogenates. Treatment with DBTG restrained the expression of NOX4 compared to the model group. Present study confirms that DBTG inhibits BLM-induced PF by modulating the level of oxidative stress via suppressing NOX4. PMID:26347805

  7. Isolates of Liao ning virus from wild-caught mosquitoes in the Xinjiang province of China in 2005.

    Directory of Open Access Journals (Sweden)

    Xinjun Lv

    Full Text Available Liao ning virus (LNV is related to Banna virus, a known human-pathogen present in south-east Asia. Both viruses belong to the genus Seadornavirus, family Reoviridae. LNV causes lethal haemorrhage in experimentally infected mice. Twenty seven isolates of LNV were made from mosquitoes collected in different locations within the Xinjiang province of north-western China during 2005. These mosquitoes were caught in the accommodation of human patients with febrile manifestations, or in animal barns where sheep represent the main livestock species. The regions where LNV was isolated are affected by seasonal encephalitis, but are free of Japanese encephalitis (JE. Genome segment 10 (Seg-10 (encoding cell-attachment and serotype-determining protein VP10 and Seg-12 (encoding non-structural protein VP12 were sequenced for multiple LNV isolates. Phylogenetic analyses showed a less homogenous Seg-10 gene pool, as compared to segment 12. However, all of these isolates appear to belong to LNV type-1. These data suggest a relatively recent introduction of LNV into Xinjiang province, with substitution rates for LNV Seg-10 and Seg-12, respectively, of 2.29×10(-4 and 1.57×10(-4 substitutions/nt/year. These substitution rates are similar to those estimated for other dsRNA viruses. Our data indicate that the history of LNV is characterized by a lack of demographic fluctuations. However, a decline in the LNV population in the late 1980s-early 1990s, was indicated by data for both Seg-10 and Seg-12. Data also suggest a beginning of an expansion in the late 1990s as inferred from Seg-12 skyline plot.

  8. Identification and comparative quantification of bio-active phthalides in essential oils from si-wu-tang, fo-shou-san, radix angelica and rhizoma chuanxiong.

    Science.gov (United States)

    Tang, Yuping; Zhu, Min; Yu, Sheng; Hua, Yongqing; Duan, Jin-Ao; Su, Shulan; Zhang, Xu; Lu, Yin; Ding, Anwei

    2010-01-15

    Phthalides are important bio-active constituents in Si-Wu-Tang and Fo-Shou-San, two commonly used Traditional Chinese Medicine (TCM) combined prescriptions mainly derived from Radix Angelica and Rhizoma Chuanxiong. In this paper, the contents of eight phthalides, including Z-ligustilide, E-ligustilide, Z-butylenephthalide, E-butylene-phthalide, 3-butylphthalide, neocnidilide and senkyunolide A were determined or estimated by gas chromatography-mass spectrometry (GC-MS). The results showed GC-MS was a simple, rapid, and high sensitive method for analyzing phthalides in Si-Wu-Tang, Fo-Shou-San, Radix Angelica and Rhizoma Chuanxiong, and the extractable contents of each phthalides including Z-ligustilide, E-ligustilide, Z-butylenephthalide, etc. varied after Radix Angelica, Rhizoma Chuanxiong were combined into a formulation, such as Si-Wu-Tang and Fo-Shou-San. Furthermore, inhibition activity of essential oils from Si-Wu-Tang, Fo-Shou-San, Radix Angelica and Rhizoma Chuanxiong on uterine contraction was tested in an in vitro assay, and the results showed that the activity of the essential oil is higher as the content of the phthalides increase, which demonstrated that phthalides are possibly main active components inhibiting mice uterine contraction in vitro. All of the results suggested that comparative analysis of chemical components and pharmacological activities of each herb and formula is possibly helpful to elucidate the active components in traditional Chinese medicine, and to reveal the compatibility mechanism of TCM formulae.

  9. The influence of intestine-based treatment using Xuan Bai Cheng Qi Tang on the concentration of trace elements in the main organs of COPD rats

    Directory of Open Access Journals (Sweden)

    Jiamin Yang

    2017-01-01

    Conclusion: This study showed that “treating from the intestine” using Xuan Bai Cheng Qi Tang and its modified formulae can regulate the concentration of trace elements in the main organs of COPD rats. This may be one of the mechanisms for intestine-based treatment for COPD.

  10. Andmete väljastamine sideettevõtjate poolt jälitus- ja julgeolekuasutustele ning teistele selleks õigustatud isikutele : [bakalaureusetöö] / Kati Ambo-Vaher ; Tartu Ülikool, õigusteaduskond ; juhendaja: Andres Vutt

    Index Scriptorium Estoniae

    Ambo-Vaher, Kati

    2007-01-01

    Andmete väljastamise põhiseaduslikud piirangud ja isikuandmete kaitse, sideettevõtjate poolt andmete väljastamine jälitus- ja julgeolekuasutustele ning teistele selleks õigustatud isikutele, logifailide ja päringute säilitamise kohustus ning järelevalve, andmete väljastamisega kaasnevate kulude hüvitamine

  11. Changes of Some Indices of Low Flow affected by Climate Change in the Tang Panj Sezar Basin

    Directory of Open Access Journals (Sweden)

    M. Mozayyan

    2016-10-01

    Full Text Available Introduction: Due to the effects of climate change on water resources and hydrology, Changes in low flow as an important part of the water cycle, is of interest to researchers, water managers and users in various fields. Changes in characteristics of low flows affected by climate change may have important effects on various aspects of socioeconomic , environmental, water resources and governmental planning. There are several indices to assess the low flows. The used low flow indices in this research for assessing climate change impacts, is include the extracted indices from flow duration curve (Q70, Q90 and Q95, due to the importance of these indices in understanding and assessing the status of river flow in dry seasons that was investigated in Tang Panj Sezar basin in the west of Iran. Materials and methods: In this paper, the Tang Panj Sezar basin with an area of 9410 km2 was divided into 6 smaller sub catchments and the changes of low flow indices were studied in each of the sub catchments. In order to consider the effects of climate change on low flow, scenarios of temperature and precipitation using 10 atmospheric general circulation models (to investigate the uncertainty of GCMs for both the baseline (1971-2000 and future (2011-2040 under A2 emission scenario was prepared. These scenarios, due to large spatial scale need to downscaling. Therefore, LARS-WG stochastic weather generator model was used. In order to consider the effects of climate change on low flows in the future, a hydrologic model is required to simulate daily flow for 2011-2040. The IHACRES rainfall-runoff model was used for this purpose . After simulation of daily flow using IHACRES, with two time series of daily flow for the observation and future period in each of the sub catchment, the low flow indices were compared. Results Discussion: According to results, across the whole year, the monthly temperature in the future period has increased while rainfall scenarios show

  12. 2. XII möödus 20 aastat Adamson-Ericu muuseumi avamisest Eesti Kunstimuuseumi filiaalina ning 35 aastat Adamson-Ericu (1902-1968) surmast

    Index Scriptorium Estoniae

    2003-01-01

    Muuseumi ajaloost, põhikogust, Adamson-Ericu teoste põhiekspositsioonist, kunstinäitustest. 3. XII tutvustab Kersti Koll Adamson-Ericu ja läti kunstniku Ludolfs Libertsi näitust. 5. XII ekspositsioonis ringkäik "Meistri töövõtetest ning erinevatest materjalidest restauraatori pilgu läbi" Alar Nurkse juhtimisel, ekskursioon Ülle Kruusi juhtimisel. 10. XII algab projekti "Avatud muuseum" raames haridusprogramm "Noor kunstidetektiiv"

  13. Effects of Chowiseungcheng-tang Extracts on the Preadipocytes Proliferation in 3T3-L1 cell line, Lipolysis of Adipocytes in rat, and Localized Fat Accumulation by extraction methods

    Directory of Open Access Journals (Sweden)

    Jae-eun, Lee

    2008-03-01

    Full Text Available Objectives : The purpose of this study is to investigate the effects of Chowiseungcheng-tang extracts on the preadipocytes proliferation in 3T3-L1 cell line, lipolysis of adipocytes in rat’s epididymal adipocytes and localized fat accumulation of porcine by extraction methods(alcohol and water. Methods : Diminish preadipocytes proliferation and promote lipolysis of adipocytes do primary role to reduce obesity. So, we used 3T3-L1 mouse embryo fibroblasts(preadipocytes and rat epididymal adipocytes from Sprague-Dawley rats to investigate the effects of Chowiseungcheng-tang extracts on the preadipocytes proliferation, lipolysis of adipocytes. They were treated with 0.01, 0.1, 1.0㎎/㎖ Chowiseungcheng-tang alcohol and water extracts. And for the purpose of investigating the effects of Chowiseungcheng-tang alcohol and water extracts on the localized fat accumulation, we injected 0.1, 1.0, 10.0㎎/㎖ Chowiseungcheng-tang extracts to porcine fat tissues and observed histological changes of them. Results : Following results were obtained from the preadipocytes proliferation and lipolysis of adipocytes and histological investigation of fat tissues. 1. Chowiseungcheng-tang extracts suppressed preadipocytes proliferation on the high dosage(especially 1.0㎎/㎖, and especially alcohol extracts had better effects. 2. The alcohol extracts of Chowiseungcheng-tang decreased the activity of glycerol-3-phosphate dehydrogenase(GPDH on the concentrations of 0.1, 1.0㎎/㎖. Alcohol extracts had better effects than water extracts. 3. Chowiseungcheng-tang extracts increased lipolysis of adipocytes on the concentrations of 0.1, 1.0㎎/㎖, and especially on the concentration of 1.0㎎/㎖ alcohol extract of Chowiseungcheng-tang had better effect. 4. The water extract of Chowiseungcheng-tang had significant activity to the destruction of porcine fat cell membranes only on the concentration of 10.0㎎/㎖, but alcohol extracts of Chowiseungcheng-tang had it on all

  14. Euroopa Inimõiguste Kohtu lahendid asjades Kolk ja Kislõi vs Eesti ning Kononov vs Läti - sarnasused, vastuolud ning Euroopa Inimõiguste Kohtu argumentide põhistatus : [bakalaureusetöö] / Martin Häidberg ; Tartu Ülikool, õigusteaduskond ; j

    Index Scriptorium Estoniae

    Häidberg, Martin

    2010-01-01

    Võrdlevast kirjeldusest Euroopa Inimõiguste Kohtu seisukohtades. Sõjakuritegudest ja inimsusevastastest kuritegudest ning konventsioonist aegumistähtaegade kohaldamatuse kohta, inimõiguste ja põhivabaduste kaitse konventsiooni artikli 7 rikkumisest ja EIÕK põhjendustest, otsuste kriitikast, põhistatusest ja vastuoludest teiste lahenditega

  15. Yukmijihwang-tang for the treatment of xerostomia in the elderly: study protocol for a randomized, double-blind, placebo-controlled, two-center trial.

    Science.gov (United States)

    Han, Gajin; Park, Jae-Woo; Ko, Seok-Jae; Son, Jihee; Seon, Jongki; Kim, Juyeon; Kim, Seulki; Yeo, Inkwon; Ryu, Bongha; Kim, Jinsung

    2013-09-03

    Xerostomia, a subjective sense of dry mouth, is not generally regarded a disease despite its high prevalence among the elderly, and therefore continues to impair affected patients' quality of life. In traditional Korean medicine, 'Yin-Deficiency' has been implicated in the pathogenesis of xerostomia among the elderly. Yukmijihwang-tang is a famous herbal prescription used to relieve 'Yin-Deficiency', and reportedly has antioxidant effects; therefore, it is postulated that Yukmijihwang-tang can be used to treat xerostomia in the elderly. However, to our knowledge, no clinical trial has been conducted on the effects of Yukmijihwang-tang on xerostomia. Thus, we designed a randomized clinical trial to investigate the effects and safety of Yukmijihwang-tang on xerostomia in the elderly. In addition, we will clarify the aforementioned assumption that 'Yin-Deficiency' is the major cause of xerostomia in the elderly by identifying a correlation between xerostomia and 'Yin-Deficiency'. This randomized, double-blind, placebo-controlled trial will be carried out at two centers: Kyung Hee University Korean Medicine Hospital and Kyung Hee University Hospital at Gangdong. We will recruit 96 subjects aged 60-80 years who have experienced xerostomia for 3 months prior to participation. Subjects who present with score >40 on the visual analogue scale for xerostomia and unstimulated salivary flow rate under 0.3mL/min will be included and the randomization will be carried out by an independent statistician by using a random number creation program. The subjects and all researchers except the statistician will be blinded to the group assignment. Yukmijihwang-tang or placebo will be administered to each group for 8 weeks. The primary outcome is change in the scores for the visual analogue scale for xerostomia and the dry mouth symptom questionnaire from 0 to 8 weeks. It will be assessed whether Yukmijihwang-tang can be used as a new herbal treatment for xerostomia in the elderly by

  16. Clinical Efficacy of Traditional Chinese Medicine, Suan Zao Ren Tang, for Sleep Disturbance during Methadone Maintenance: A Randomized, Double-Blind, Placebo-Controlled Trial

    OpenAIRE

    Chan, Yuan-Yu; Chen, Yi-Hung; Yang, Szu-Nian; Lo, Wan-Yu; Lin, Jaung-Geng

    2015-01-01

    Methadone maintenance therapy is an effective treatment for opiate dependence, but more than three-quarters of persons receiving the treatment report sleep quality disturbances. In this double-blind, randomized, controlled trial, we recruited 90 individuals receiving methadone for at least one month who reported sleep disturbances and had Pittsburgh Sleep Quality Index (PSQI) scores > 5. The purpose of this study was to determine whether Suan Zao Ren Tang, one of the most commonly prescribed ...

  17. A new genus of oak gallwasp, Cyclocynips Melika, Tang & Sinclair (Hymenoptera: Cynipidae: Cynipini), with descriptions of two new species from Taiwan.

    Science.gov (United States)

    Melika, George; Tang, Chang-ti; Sinclair, Frazer; Yang, Man-miao; Lohse, Konrad; Hearn, Jack; Nicholls, James A; Stone, Graham N

    2013-01-01

    A new genus of cynipid oak gallwasp-Cyclocynips Melika, Tang, & Sinclair (Hymenoptera: Cynipidae: Cynipini), with two new species--C. uberis and C. tumorvirgae--reared from galls on oaks of the Quercus subgenus Cyclobalanopsis is described from Taiwan. Descriptions of asexual generation adults and their diagnostic characters are presented. The likelihood of yet undiscovered sexual generations and the evolution of host-plant associations in these species are discussed.

  18. Variations de la température de l'eau des étangs en période froide à ...

    African Journals Online (AJOL)

    SARAH

    30 juin 2015 ... Conclusion et application : La mise en évidence de la courbe de variation de température en période froide à Lubumbashi est cruciale pour la mise en place des systèmes de .... niloticus) et le poisson-chat africain (Clarias ngamensis et Clarias gariepinus). Les étangs dont la profondeur varie entre 120 et ...

  19. Optimization of high pressure machine decocting process for Dachengqi Tang using HPLC fingerprints combined with the Box–Behnken experimental design

    OpenAIRE

    Xie, Rui-Fang; Shi, Zhi-Na; Li, Zhi-Cheng; Chen, Pei-Pei; Li, Yi-Min; Zhou, Xin

    2014-01-01

    Using Dachengqi Tang (DCQT) as a model, high performance liquid chromatography (HPLC) fingerprints were applied to optimize machine extracting process with the Box–Behnken experimental design. HPLC fingerprints were carried out to investigate the chemical ingredients of DCQT; synthetic weighing method based on analytic hierarchy process (AHP) and criteria importance through intercriteria correlation (CRITIC) was performed to calculate synthetic scores of fingerprints; using the mark ingredien...

  20. Cheongsangbangpung-tang ameliorated the acute inflammatory response via the inhibition of NF-κB activation and MAPK phosphorylation.

    Science.gov (United States)

    Kim, Seon Young; Park, Sang Mi; Hwangbo, Min; Lee, Jong Rok; Byun, Sung Hui; Ku, Sae Kwang; Cho, Il Je; Kim, Sang Chan; Jee, Seon Young; Park, Sook Jahr

    2017-01-13

    Cheongsangbangpung-tang (CBT) is a traditional herbal formula used in Eastern Asia to treat heat-related diseases and swellings in the skin. The present study was conducted to evaluate the anti-inflammatory effects of cheongsangbangpung-tang extract (CBTE) both in vitro and in vivo. The in vitro effects of CBTE on the lipopolysaccharide (LPS)-induced production of inflammation-related proteins were examined in RAW 264.7 cells. The levels of nitric oxide (NO) were measured with the Griess reagent. Inflammatory cytokines and prostaglandin E 2 (PGE 2 ) were detected using the enzyme-linked immunosorbent assay (ELISA) method. Inflammation-related proteins were detected by Western blot. The effect of CBTE on acute inflammation in vivo was evaluated using carrageenan (CA)-induced paw oedema. To evaluate the anti-inflammatory effect, paw oedema volume, thickness of the dorsum and ventrum pedis skin, number of infiltrated inflammatory cells, and number of COX-2-, iNOS-immunoreactive cells were measured. In an in vitro study, CBTE inhibited the production of NO and PGE 2 and also decreased the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) activity, interleukin (IL)-1β, IL-6 and tumuor necrosis factor-α. In LPS-activated macrophages, nuclear factor-kappaB (NF-κB) and mitogen-activated protein kinase (MAPK) signalling is a pivotal pathway in the inflammatory process. These plausible molecular mechanisms increased the phosphorylation of I-κBα, while the activation of NF-κB and the phosphorylation of MAPK by LPS were blocked by CBTE treatment. In our in vivo study, a CA-induced acute oedematous paw inflammation rat model was used to evaluate the anti-inflammatory effect of CBTE. CBTE significantly reduced the increases in paw swelling, skin thicknesses, infiltrated inflammatory cells and iNOS-, COX-2 positive cells induced by CA injection. Based on these results, CBTE should favourably inhibit the acute inflammatory response through

  1. Helmet "tang" from the Metropolitan Museum of Art (New York City, United States. Features of Construction, Design and Operational Use

    Directory of Open Access Journals (Sweden)

    Leonid A. Bobrov

    2016-12-01

    Full Text Available The article discusses iron helmet (No. 36.25.115, which is stored in the Metropolitan Museum of art (New York City, United States. For the first time this helmet was published and analyzed by American scientists G. C. Stone and D.G. Alexander. The analysis showed that the Bowl was made by Turkish masters of the XVII century and backplate and the hoop is added to the helmet in 1781–1782 D.G. Alexander speculated that the helmet belonged to the Warrior of the Crimean Khanate. Dating the helmet does not raise objections. However, the attribution of a helmet requires some clarification. Analysis of the design of the helmet and decoration revealed that backplate, hoop and Aventail from iron rings added to Bowl in 1781–1782, were manufactured by Circassian craftsmen living in the Northern Caucasus or in Crimea. For the decoration of the helmet has been used typical Circassian ornaments: "sieve", cherkessian floral pattern, geometric shapes, triangular in shape, "gear", etc. During Assembly of the helmet were applied characteristic of Circassian gunsmiths technological solutions: using as a basis the bowl old-style helmet, tapered Finial with a ring for a decorative plume, hoop with four plates, ringed with aventail lip to protect the forehead, etc. In Circassia similar headgear worn were known as tang (from the Arabic. "Taj", i.e., the "Crown". In the XVII–XVIII centuries. they willingly purchased representatives of Crimean Tatar nobility. Similar in design and system design helmets Circassian production belonged to the highest aristocracy of the Crimean Khanate, are stored in Museum and private collections in Poland, Turkey and the United States. The inscription "Bekmurun" on the hoop from the Metropolitan helmet suggests that it was manufactured on request of Kabardian Bekmur princely heir (Bekmurziny, which moved from Circassia in Crimea, 1737. The popularity of tang type helmets among the aristocracy of North Caucasus and Crimea were due not

  2. Clinical Efficacy of Traditional Chinese Medicine, Suan Zao Ren Tang, for Sleep Disturbance during Methadone Maintenance: A Randomized, Double-Blind, Placebo-Controlled Trial

    Science.gov (United States)

    Chan, Yuan-Yu; Chen, Yi-Hung; Yang, Szu-Nian; Lo, Wan-Yu; Lin, Jaung-Geng

    2015-01-01

    Methadone maintenance therapy is an effective treatment for opiate dependence, but more than three-quarters of persons receiving the treatment report sleep quality disturbances. In this double-blind, randomized, controlled trial, we recruited 90 individuals receiving methadone for at least one month who reported sleep disturbances and had Pittsburgh Sleep Quality Index (PSQI) scores > 5. The purpose of this study was to determine whether Suan Zao Ren Tang, one of the most commonly prescribed traditional Chinese medications for treatment of insomnia, improves subjective sleep among methadone-maintained persons with disturbed sleep quality. Ninety patients were randomly assigned to intervention group (n = 45) and placebo group (n = 45), and all participants were analyzed. Compared with placebo treatment, Suan Zao Ren Tang treatment for four weeks produced a statistically significant improvement in the mean total PSQI scores (P = 0.007) and average sleep efficiency (P = 0.017). All adverse events (e.g., lethargy, diarrhea, and dizziness) were mild in severity. Suan Zao Ren Tang is effective for improving sleep quality and sleep efficiency among methadone-maintained patients with sleep complaints. PMID:26346534

  3. Clinical Efficacy of Traditional Chinese Medicine, Suan Zao Ren Tang, for Sleep Disturbance during Methadone Maintenance: A Randomized, Double-Blind, Placebo-Controlled Trial

    Directory of Open Access Journals (Sweden)

    Yuan-Yu Chan

    2015-01-01

    Full Text Available Methadone maintenance therapy is an effective treatment for opiate dependence, but more than three-quarters of persons receiving the treatment report sleep quality disturbances. In this double-blind, randomized, controlled trial, we recruited 90 individuals receiving methadone for at least one month who reported sleep disturbances and had Pittsburgh Sleep Quality Index (PSQI scores > 5. The purpose of this study was to determine whether Suan Zao Ren Tang, one of the most commonly prescribed traditional Chinese medications for treatment of insomnia, improves subjective sleep among methadone-maintained persons with disturbed sleep quality. Ninety patients were randomly assigned to intervention group (n=45 and placebo group (n=45, and all participants were analyzed. Compared with placebo treatment, Suan Zao Ren Tang treatment for four weeks produced a statistically significant improvement in the mean total PSQI scores (P=0.007 and average sleep efficiency (P=0.017. All adverse events (e.g., lethargy, diarrhea, and dizziness were mild in severity. Suan Zao Ren Tang is effective for improving sleep quality and sleep efficiency among methadone-maintained patients with sleep complaints.

  4. Fighting Swaying Imbalances of Powers: The Transformation of Spiritual Freedom in Tang Tales into Individual Freedom in Hou Hsiao-hsien’s The Assassin

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    Frank Kraushaar

    2018-03-01

    Full Text Available The appearance of Hou Hsiao-hsien’s 侯孝賢 film The Assassin in 2015 and its distinction the same year with the Best Director’s award at the film festival in Cannes has launched an avalanche of confused and confusing reviews in print-media and on the internet. This partly may have been due to the gap between expectations the film’s attribution to the wuxia genre generated in the public and what actually Hou expects from his audience. Despite an unmistakable historical contextualisation at the heart of power-struggling between the Tang imperial court and the ruling house of Weibo, a state that manages to assert its de facto independence behind a diaphanous diplomatic veil of loyalty, the story of the young female assassin Nie Yinniang develops into a sphere of its own, which seems to extend beyond the confines of history and strongly suggests a freedom unspeakable within the intellectual parameter of Tang. This paper traces back the film’s narrative based on Tang dynasty tales and its cinematic language, and arrives at an interpretation related to contemporary social and political topics such as the female/male body and violence. It also touches upon the cross-strait relations’ issues and the “Western” idea of freedom expressed in an apparently traditional Chinese narrative context.

  5. Uimastite mõju Eesti koolinoorte isiksuse arengule ning nende kuritegelikule käitumisele : [bakalaureusetöö] / Vaike Kargu ; Tartu Ülikool, õigusteaduskond ; juhendaja: Silvia Kaugia

    Index Scriptorium Estoniae

    Kargu, Vaike

    2010-01-01

    Legaalsetest uimastitest ja nende esmatarbimise east Eestis, Eesti koolinoorte seas enamkasutatavatest illegaalsetest uimastitest ning nende mõjust koolinoorte käitumisele, sotsiaalõiguslikest tagajärgedest, alaealiste kuritegevusest, ennetustegevusest

  6. Director läks ja küsis : Milliste omadustega töötajaid te tahate tööle võtta ning millised inimesed teile ei sobi? / Janika Kuusik, Anni Pikk, Merike Jaamul... [jt.

    Index Scriptorium Estoniae

    2010-01-01

    Elioni personalijuht Janika Kuusik, TNT Eesti personalispetsialist Anni Pikk, Eesti Posti personalijuht Merike Jaamul, advokaadibüroo Sorainen personalijuht Kristiina Härms ning Webmedia personalijuht Kairi Pauskar vastavad küsimusele, milliseid inimesi nad eelistavad palgata

  7. Joobes mootorsõiduki juhtide karistamine ning ennetusmeetmed Eestis, Rootsis, Soomes ja Venemaal : [magistritöö] / August Käära ; Tartu Ülikool, õigusteaduskond ; juhendaja: Silvia Kaugia

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    Käära, August

    2011-01-01

    Alkoholi- ja narkojoobe ning -sõltuvuse olemusest ja joobe õigustamise sotsiaalsetest teooriatest, karistamise alustest mootorsõiduki joobes juhtimise eest, sotsiaalprogrammidest - nende analüüsist ja ennetusmeetmetest

  8. Tallinnasse Rävala pst. 19 kavandatava Tallinna Muusikakeskkooli, Tallinna Balletikooli ning G. Otsa nimelise muusikakooli ühise õppehoone arhitektuurikonkurss = Architectural Competition for the Joint School Building of Tallinn Music-Specialised

    Index Scriptorium Estoniae

    Puusepp, Raivo

    2003-01-01

    I preemia - Andres Siim, Krister Ausing, II - Marika Lõoke, III - Maia Tüür, Andres Sevtshuk, Gabriel Evangelisti, ostupreemiad: Armin Valter, Vilen Künnapu ning Siiri Vallner, Katrin Koov, Veronika Valk

  9. Study on energy efficiency in Vietnamese row house - case study of Tang Nhon Phu A Ward, District 9, HCMC

    Science.gov (United States)

    Thao, H. T. P.; Nam, N. D.

    2018-04-01

    District 9 is a new urban development area which is well-known as an industrial city in the rear of Ho Chi Minh City. This area has special characteristics which are different from central downtown. The housing of district 9 is a new urban area so that it is easier to orient particular architectural style accordance with climatic conditions and other conditions. However, at present, these new residential areas are rising with no clear management of architectural form. That is the reason lead to shortcomings such as: increasing the use of electricity, affecting to climate change and creating urban heat island, increasing costs of energy use. Those problems will be difficult to overcome in the future if we don’t have the right attention on it. By using a combination of multiple methods such as: data collection, case study analysis method, GIS, research by design, etc., this research topic will pay attention on analysis the row house in Tang Nhon Phu A Ward of district 9 and trying to propose some solution and management criteria to local government. The analysis results will ensure that the conclusions reflect the realities of the situation, those also become the basis for the proposed solutions to deal with the existence problems. The result of research may become an application research platform for the related research topics.

  10. Advancing Drug Discovery and Development from Active Constituents of Yinchenhao Tang, a Famous Traditional Chinese Medicine Formula

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    Aihua Zhang

    2013-01-01

    Full Text Available Traditional Chinese medicine (TCM formula has been playing a very important role in health protection and disease control for thousands of years. Guided by TCM syndrome theories, formula are designed to contain a combination of various kinds of crude drugs that, when combined, will achieve synergistic efficacy. However, the precise mechanism of synergistic action remains poorly understood. One example is a famous TCM formula Yinchenhao Tang (YCHT, whose efficacy in treating hepatic injury (HI and Jaundice syndrome, has recently been well established as a case study. We also conducted a systematic analysis of synergistic effects of the principal compound using biochemistry, pharmacokinetics and systems biology, to explore the key molecular mechanisms. We had found that the three component (6,7-dimethylesculetin (D, geniposide (G, and rhein (R combination exerts a more robust synergistic effect than any one or two of the three individual compounds by hitting multiple targets. They can regulate molecular networks through activating both intrinsic and extrinsic pathways to synergistically cause intensified therapeutic effects. This paper provides an overview of the recent and potential developments of chemical fingerprinting coupled with systems biology advancing drug discovery towards more agile development of targeted combination therapies for the YCHT.

  11. Evaluation on the Pharmacological Effect of Traditional Chinese Medicine SiJunZiTang on Stress-Induced Peptic Ulcers

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    Chiu-Mei Chen

    2013-01-01

    Full Text Available Purpose. To explore the effects of SiJunZiTang (SJZT on central neurotransmitters and the inhibition of HCl hypersecretion, along with the role of the vagus nerve. From this, the effects of SJZT and its constituent ingredients on inhibiting stress-induced peptic ulcers will be determined. Methods. Methods used to determine SJZT's effectiveness included (1 measuring the antipeptic ulcer effects of varying combinations of the constituents of SJZT; (2 evaluations of monoamine (MA level in the brain; and (3 measuring the effects of longer-term SJZT treatment. Results. Comparing the control and experimental groups where the rats’ vagus nerves were not cut after taking SJZT orally (500 mg/kg and 1000 mg/kg, the volume of enterogastric juice, free HCl and total acidity all reduce dose-dependently. The group administered SJZT at 1000 mg/kg showed significant reductions (P<0.05. For the experimental groups where the vagus nerves were cut, a comparison with the control group suggests that the group receiving SJZT (500 mg/kg orally for 21 days demonstrated a cure rate of 34.53%. Conclusion. The results display a correlation between the therapeutic effects of SJZT on stress-induced peptic ulcers and central neurotransmitter levels. Further to this, SJZT can inhibit the hypersecretion of HCl in the stomach, thus inhibiting stress-induced peptic ulcers.

  12. Evaluation on the Pharmacological Effect of Traditional Chinese Medicine SiJunZiTang on Stress-Induced Peptic Ulcers.

    Science.gov (United States)

    Chen, Chiu-Mei; Lee, Chien-Ying; Lin, Po-Jung; Hsieh, Chin-Lang; Shih, Hung-Che

    2013-01-01

    Purpose. To explore the effects of SiJunZiTang (SJZT) on central neurotransmitters and the inhibition of HCl hypersecretion, along with the role of the vagus nerve. From this, the effects of SJZT and its constituent ingredients on inhibiting stress-induced peptic ulcers will be determined. Methods. Methods used to determine SJZT's effectiveness included (1) measuring the antipeptic ulcer effects of varying combinations of the constituents of SJZT; (2) evaluations of monoamine (MA) level in the brain; and (3) measuring the effects of longer-term SJZT treatment. Results. Comparing the control and experimental groups where the rats' vagus nerves were not cut after taking SJZT orally (500 mg/kg and 1000 mg/kg), the volume of enterogastric juice, free HCl and total acidity all reduce dose-dependently. The group administered SJZT at 1000 mg/kg showed significant reductions (P cure rate of 34.53%. Conclusion. The results display a correlation between the therapeutic effects of SJZT on stress-induced peptic ulcers and central neurotransmitter levels. Further to this, SJZT can inhibit the hypersecretion of HCl in the stomach, thus inhibiting stress-induced peptic ulcers.

  13. Suan Zao Ren Tang as an Original Treatment for Sleep Difficulty in Climacteric Women: A Prospective Clinical Observation

    Science.gov (United States)

    Yeh, Chia-Hao; Arnold, Christof K.; Chen, Yen-Hui; Lai, Jung-Nein

    2011-01-01

    Little scientific evidence supports the efficacy of herbal medicines in the treatment of women with sleep difficulty during the climacteric period. The purpose of this study is to evaluate the efficacy and safety of Suan Zao Ren Tang (SZRT) in reducing the impact of sleep disturbance on climacteric women, as measured by Pittsburg sleep quality index (PSQI) and the World Health Organization quality of life (WHOQOL). Sixty-seven climacteric women with sleep difficulty intending to treat received SZRT at a rate of 4.0 g, thrice daily for four weeks (MRS < 16, n = 34; MRS ≥ 16, n = 33). After taking into account potential confounding factors, the mean PSQI total scores had fallen from 13.0 (±2.9) to 9.0 (±3.2) (95% confidence interval −4.93, −3.10). Further analyses showed that SZRT produced superior benefit of daytime dysfunction in women with severe menopausal symptoms (MRS ≥ 16). There were three of the withdrawals involved treatment-related adverse events (stomachache, diarrhea, and dizziness). Excluding women with a past history of stomachache, diarrhea, or dizziness, four weeks of therapy with SZRT appears to be a relatively safe and effective short-term therapeutic option in improving daytime function of climacteric women with poor sleep quality. PMID:21660310

  14. Suan Zao Ren Tang as an Original Treatment for Sleep Difficulty in Climacteric Women: A Prospective Clinical Observation

    Directory of Open Access Journals (Sweden)

    Chia-Hao Yeh

    2011-01-01

    Full Text Available Little scientific evidence supports the efficacy of herbal medicines in the treatment of women with sleep difficulty during the climacteric period. The purpose of this study is to evaluate the efficacy and safety of Suan Zao Ren Tang (SZRT in reducing the impact of sleep disturbance on climacteric women, as measured by Pittsburg sleep quality index (PSQI and the World Health Organization quality of life (WHOQOL. Sixty-seven climacteric women with sleep difficulty intending to treat received SZRT at a rate of 4.0 g, thrice daily for four weeks (MRS<16, n=34; MRS≥16, n=33. After taking into account potential confounding factors, the mean PSQI total scores had fallen from 13.0 (±2.9 to 9.0 (±3.2 (95% confidence interval −4.93, −3.10. Further analyses showed that SZRT produced superior benefit of daytime dysfunction in women with severe menopausal symptoms (MRS≥16. There were three of the withdrawals involved treatment-related adverse events (stomachache, diarrhea, and dizziness. Excluding women with a past history of stomachache, diarrhea, or dizziness, four weeks of therapy with SZRT appears to be a relatively safe and effective short-term therapeutic option in improving daytime function of climacteric women with poor sleep quality.

  15. Evaluating the Bone Tissue Regeneration Capability of the Chinese Herbal Decoction Danggui Buxue Tang from a Molecular Biology Perspective

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    Wen-Ling Wang

    2014-01-01

    Full Text Available Large bone defects are a considerable challenge to reconstructive surgeons. Numerous traditional Chinese herbal medicines have been used to repair and regenerate bone tissue. This study investigated the bone regeneration potential of Danggui Buxue Tang (DBT, a Chinese herbal decoction prepared from Radix Astragali (RA and Radix Angelicae Sinensis (RAS, from a molecular biology perspective. The optimal ratio of RA and RAS used in DBT for osteoblast culture was obtained by colorimetric and alkaline phosphatase (ALP activity assays. Moreover, the optimal concentration of DBT for bone cell culture was also determined by colorimetric, ALP activity, nodule formation, Western blotting, wound-healing, and tartrate-resistant acid phosphatase activity assays. Consequently, the most appropriate weight ratio of RA to RAS for the proliferation and differentiation of osteoblasts was 5 : 1. Moreover, the most effective concentration of DBT was 1,000 μg/mL, which significantly increased the number of osteoblasts, intracellular ALP levels, and nodule numbers, while inhibiting osteoclast activity. Additionally, 1,000 μg/mL of DBT was able to stimulate p-ERK and p-JNK signal pathway. Therefore, DBT is highly promising for use in accelerating fracture healing in the middle or late healing periods.

  16. Effect of Sipjeondaebo-tang on cancer-induced anorexia and cachexia in CT-26 tumor-bearing mice.

    Science.gov (United States)

    Choi, Youn Kyung; Jung, Ki Yong; Woo, Sang-Mi; Yun, Yee Jin; Jun, Chan-Yong; Park, Jong Hyeong; Shin, Yong Cheol; Cho, Sung-Gook; Ko, Seong-Gyu

    2014-01-01

    Cancer-associated anorexia and cachexia are a multifactorial condition described by a loss of body weight and muscle with anorexia, asthenia, and anemia. Moreover, they correlate with a high mortality rate, poor response to chemotherapy, poor performance status, and poor quality of life. Cancer cachexia is regulated by proinflammatory cytokines such as interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factor- α (TNF- α). In addition, glucagon like peptide-1 (GIP-1), peptide YY (PYY), ghrelin, and leptin plays a crucial role in food intake. In this study, we investigated the therapeutic effects of one of the traditional herbal medicines, Sipjeondaebo-tang (Juzen-taiho-to in Japanese; SJDBT), on cancer anorexia and cachexia in a fundamental mouse cancer anorexia/cachexia model, CT-26 tumor-bearing mice. SJDBT was more significantly effective in a treatment model where it was treated after anorexia and cachexia than in a prevention model where it was treated before anorexia and cachexia on the basis of parameters such as weights of muscles and whole body and food intakes. Moreover, SJDBT inhibited a production of IL-6, MCP-1, PYY, and GLP-1 and ameliorated cancer-induced anemia. Therefore, our in vivo studies provide evidence on the role of SJDBT in cancer-associated anorexia and cachexia, thereby suggesting that SJDBT may be useful for treating cancer-associated anorexia and cachexia.

  17. Renal Protective Effect of Xiao-Chai-Hu-Tang on Diabetic Nephropathy of Type 1-Diabetic Mice

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    Chun-Ching Lin

    2012-01-01

    Full Text Available Xiao-Chai-Hu-Tang (XCHT, a traditional Chinese medicine formula consisting of seven medicinal plants, is used in the treatment of various diseases. We show here that XCHT could protect type-1 diabetic mice against diabetic nephropathy, using streptozotocin (STZ-induced diabetic mice and high-glucose (HG-exposed rat mesangial cell (RMC as models. Following 4 weeks of oral administration with XCHT, renal functions and renal hypertrophy significantly improved in the STZ-diabetic mice, while serum glucose was only moderately reduced compared to vehicle treatment. Treatment with XCHT in the STZ-diabetic mice and HG-exposed RMC resulted in a decrease in expression levels of TGF-β1, fibronectin, and collagen IV, with concomitant increase in BMP-7 expression. Data from DPPH assay, DHE stain, and CM-H2DCFDA analysis indicated that XCHT could scavenge free radicals and inhibit high-glucose-induced ROS in RMCs. Taken together, these results suggest that treatment with XCHT can improve renal functions in STZ-diabetic mice, an effect that is potentially mediated through decreasing oxidative stress and production of TGF-β1, fibronectin, and collagen IV in the kidney during development of diabetic nephropathy. XCHT, therefore merits further investigation for application to improve renal functions in diabetic disorders.

  18. Evolution of the Orszag-Tang vortex system in a compressible medium. I - Initial average subsonic flow

    Science.gov (United States)

    Dahlburg, R. B.; Picone, J. M.

    1989-01-01

    The results of fully compressible, Fourier collocation, numerical simulations of the Orszag-Tang vortex system are presented. The initial conditions for this system consist of a nonrandom, periodic field in which the magnetic and velocity field contain X points but differ in modal structure along one spatial direction. The velocity field is initially solenoidal, with the total initial pressure field consisting of the superposition of the appropriate incompressible pressure distribution upon a flat pressure field corresponding to the initial, average Mach number of the flow. In these numerical simulations, this initial Mach number is varied from 0.2-0.6. These values correspond to average plasma beta values ranging from 30.0 to 3.3, respectively. It is found that compressible effects develop within one or two Alfven transit times, as manifested in the spectra of compressible quantities such as the mass density and the nonsolenoidal flow field. These effects include (1) a retardation of growth of correlation between the magnetic field and the velocity field, (2) the emergence of compressible small-scale structure such as massive jets, and (3) bifurcation of eddies in the compressible flow field. Differences between the incompressible and compressible results tend to increase with increasing initial average Mach number.

  19. Bak-Tang-Wiesenfeld model in the upper critical dimension: Induced criticality in lower-dimensional subsystems

    Science.gov (United States)

    Dashti-Naserabadi, H.; Najafi, M. N.

    2017-10-01

    We present extensive numerical simulations of Bak-Tang-Wiesenfeld (BTW) sandpile model on the hypercubic lattice in the upper critical dimension Du=4 . After re-extracting the critical exponents of avalanches, we concentrate on the three- and two-dimensional (2D) cross sections seeking for the induced criticality which are reflected in the geometrical and local exponents. Various features of finite-size scaling (FSS) theory have been tested and confirmed for all dimensions. The hyperscaling relations between the exponents of the distribution functions and the fractal dimensions are shown to be valid for all dimensions. We found that the exponent of the distribution function of avalanche mass is the same for the d -dimensional cross sections and the d -dimensional BTW model for d =2 and 3. The geometrical quantities, however, have completely different behaviors with respect to the same-dimensional BTW model. By analyzing the FSS theory for the geometrical exponents of the two-dimensional cross sections, we propose that the 2D induced models have degrees of similarity with the Gaussian free field (GFF). Although some local exponents are slightly different, this similarity is excellent for the fractal dimensions. The most important one showing this feature is the fractal dimension of loops df, which is found to be 1.50 ±0.02 ≈3/2 =dfGFF .

  20. Da-Chaihu-Tang alters the pharmacokinetics of nifedipine in rats and a treatment regimen to avoid this.

    Science.gov (United States)

    He, Ju-Xiu; Ohno, Kenji; Tang, Jun; Hattori, Masao; Tani, Tadato; Akao, Teruaki

    2014-11-01

    To investigate the influence of co-administrated Da-Chaihu-Tang (DCT; a traditional Chinese formulation) on the pharmacokinetics of nifedipine, as well as the safe optimal dosing interval to avoid the adverse interactions. A single dose of DCT was administered with nifedipine simultaneously, 2 h before, 30 min before or 30 min after nifedipine administration. Pharmacokinetics of nifedipine with or without DCT were compared. The influences of DCT on nifedipine intestinal mucosal and hepatic metabolism were studied by using rat in-vitro everted jejunal sac model and hepatic microsomes. A simultaneous co-administration of DCT significantly increased the area under concentration-time curve from time zero to infinity (AUC0-inf ) of nifedipine. In-vitro mechanism investigations revealed that DCT inhibited both the intestinal and the hepatic metabolism of nifedipine. Further study on the optimal dosing interval for nifedipine and DCT revealed that administration of DCT 30 min before or after nifedipine did not significantly change the AUC of nifedipine. The bioavailability of nifedipine is significantly increased by a simultaneous oral co-administration of DCT. This increase is caused by the inhibitory effect of DCT on both the intestinal mucosal and the hepatic metabolism of nifedipine. The dose interval between DCT and nifedipine needs to be set for over 30 min to avoid such drug-drug interactions. © 2014 Royal Pharmaceutical Society.

  1. [The influnence of dachengqi tang on acute lung injury and intra abdominal hypertension in rats with acute pancreatitis].

    Science.gov (United States)

    Wan, Mei-Hua; Li, Juan; Tang, Wen-Fu; Gong, Han-Lin; Chen, Guang-Yuan; Xue, Ping; Zhao, Xian-Lin; Xia, Qing

    2011-09-01

    To test the hypothesis "lung and large intestine are interior exteriorly related" through investgating into the effect of Dacheng qi tang (DCQT) on intra abdominal hypertension (IAH) and acute lung injury (ALI) in rats with acute pancreatitis. Male SD rats were randomly divided into three groups with ten rats for each group: rats with sham-operations (SO); rats with acute necrosis pancreatitis (ANP); rats with ANP plus DCQT treatment. ANP was induced by retrograde infusion of 5% taurocholic acid into pancreatic duct. Two hours after operations, 10 mL/kg of normal saline was orally adminstered to the rats in both SO and ANP groups, whereas 10 mL/kg DCQT was adminstered to the rats in the treatment group. Aterial blood, pancreas and lung tissues were collected for biomarkers and histopathology 24 hours after operations. Intra-abdominal pressure and intestinal propulsion rate were also measured. RESULTS; DCQT treatment reduced intra-abdominal pressure and improved intestinal propulsion rate compared with those treated with saline (P 0.05). Only two rats in the ANP group died. DCQT can effectively relieve IAH and cure ALI at the same time in rats with acute pancreatitis. The result provides evidence to support the hypothesis "lung and large intestine are interior exteriorly related".

  2. Integrated pharmacokinetics of major bioactive components in MCAO rats after oral administration of Huang-Lian-Jie-Du-Tang.

    Science.gov (United States)

    Zhu, Huaxu; Qian, Zhilei; Li, Huan; Guo, Liwei; Pan, Linmei; Zhang, Qichun; Tang, Yuping

    2012-05-07

    Huang-Lian-Jie-Du-Tang (HLJDT, or Oren-gedoku-to in Japanese), an important multi-herb remedy in China and other Asia countries, has been used clinically to treat cerebral ischemia for decades. According to the previous studies we have reported, an HPLC method was developed and validated for determination of berberine, palmatine, baicalin, baicalein and geniposide simultaneously in MCAO rat plasma after administration of HLJDT aqueous extract. A classified integral pharmacokinetic method was put forward after having compared the integrated concentration-time profile with that of single component. An AUC based weighting approach was used for integrated principle. The results indicated the classified integral pharmacokinetic profile of index components from HLJDT could reveal the pharmacokinetic behavior of original components, and was corresponding to the holistic pharmacological effects of anti-ischemia with HLJDT. This study was aimed to explore an approach that could be applied to integrate the pharmacokinetic behavior of different components derived from HLJDT. The integrated pharmacokinetic results also provided more information for further understanding of the clinical cerebrovascular disease in use of HLJDT. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  3. Bioinformatics Analysis for the Antirheumatic Effects of Huang-Lian-Jie-Du-Tang from a Network Perspective

    Directory of Open Access Journals (Sweden)

    Haiyang Fang

    2013-01-01

    Full Text Available Huang-Lian-Jie-Du-Tang (HLJDT is a classic TCM formula to clear “heat” and “poison” that exhibits antirheumatic activity. Here we investigated the therapeutic mechanisms of HLJDT at protein network level using bioinformatics approach. It was found that HLJDT shares 5 target proteins with 3 types of anti-RA drugs, and several pathways in immune system and bone formation are significantly regulated by HLJDT’s components, suggesting the therapeutic effect of HLJDT on RA. By defining an antirheumatic effect score to quantitatively measure the therapeutic effect, we found that the score of each HLJDT’s component is very low, while the whole HLJDT achieves a much higher effect score, suggesting a synergistic effect of HLJDT achieved by its multiple components acting on multiple targets. At last, topological analysis on the RA-associated PPI network was conducted to illustrate key roles of HLJDT’s target proteins on this network. Integrating our findings with TCM theory suggests that HLJDT targets on hub nodes and main pathway in the Hot ZENG network, and thus it could be applied as adjuvant treatment for Hot-ZENG-related RA. This study may facilitate our understanding of antirheumatic effect of HLJDT and it may suggest new approach for the study of TCM pharmacology.

  4. ANALYSIS OF REMOTE SENSING ARCHAEOLOGY ON TRAFFIC FUNCTION TRANSFORMATION OF TONGJI GRAND CANAL IN SUI AND TANG DYNASTIES

    Institute of Scientific and Technical Information of China (English)

    WANG Xin-yuan; HE Hui; ZHOU Ying-qiu; GAO Chao; HAN Shuang-wang

    2006-01-01

    In China, most directions of river flowing are from west to east. During historic period, since the water traffic played an important role, it was very important to form a cross-horizontal net of water carriage route. Canals should be dug so as to make up the lack of north-south river. Tongji Grand Canal, dug in the first year of Daye (605 A.D.) in the Sui Dynasty, was the important component of north-south system of Grand Canals in China. It promoted economic and social development of the Sui, Tang and Song dynasties (605 A.D.-1279 A.D.). As Tongji Canal (i.e.Tongji Grand Canal) flowed across the Huaibei Plain, which is aggraded by abundant mud and sand deposit resulted from the Huanghe (Yellow) River flooding, many traces (such as old channel) and human culture heritages were buried under mud-sand. Tongji Canal was silted up, and disappeared in the Jin Dynasty (1115 A.D.-1234 A.D.). From then on, there were many different stories about the flowing route of the canal in historical literature. Based on space-bone and air-bone remote sensing imagery, we attempt to search the old channel of Tongji Canal, and supplement historical record. The paper discusses transformation process of Tongji Canal's traffic function, and resumptively summarizes the reasons of the transformation, which results from synthetic function of physical geographical, political, economic, and social conditions.

  5. A 4-Week Repeated-Dose Oral Toxicity Study of Bojungikgi-Tang in Crl:CD Sprague Dawley Rats

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    Sae-Rom Yoo

    2017-01-01

    Full Text Available Traditional herbal medicines have been used for centuries in Asian countries. However, recent studies have led to increasing concerns about the safety and toxicity of herbal prescriptions. Bojungikgi-tang (BJIGT, a herbal decoction, has been used in Korea to improve physical strength. To establish the safety information, BJIGT water extract was evaluated in a 4-week repeated-dose oral toxicity test in Crl:CD Sprague Dawley rats. BJIGT was orally administered in daily doses of 0, 500, 1000, and 2000 mg/kg/day for 4 weeks via oral gavage in male and female rats. We examined the mortality, clinical signs, body weight change, food intake, organ weights, hematology, serum biochemistry, and urinalysis parameters. No significant changes were observed in mortality, clinical sings, body weight, food intake, organ weights, hematology, serum biochemistry, and urinalysis parameters between the control group and the BJIGT-treated groups in the rats of both sexes. The results indicate that BJIGT did not induce toxic effects at a dose level up to 2000 mg/kg in rats. Thus, this concentration is considered the nonobservable effect dose in rats and is appropriate for a 13-week subchronic toxicity study.

  6. Enhanced Bone Tissue Regeneration by Porous Gelatin Composites Loaded with the Chinese Herbal Decoction Danggui Buxue Tang.

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    Wen-Ling Wang

    Full Text Available Danggui Buxue Tang (DBT is a traditional Chinese herbal decoction containing Radix Astragali and Radix Angelicae sinensis. Pharmacological results indicate that DBT can stimulate bone cell proliferation and differentiation. The aim of the study was to investigate the efficacy of adding DBT to bone substitutes on bone regeneration following bone injury. DBT was incorporated into porous composites (GGT made from genipin-crosslinked gelatin and β-triclacium phosphates as bone substitutes (GGTDBT. The biological response of mouse calvarial bone to these composites was evaluated by in vivo imaging systems (IVIS, micro-computed tomography (micro-CT, and histology analysis. IVIS images revealed a stronger fluorescent signal in GGTDBT-treated defect than in GGT-treated defect at 8 weeks after implantation. Micro-CT analysis demonstrated that the level of repair from week 4 to 8 increased from 42.1% to 71.2% at the sites treated with GGTDBT, while that increased from 33.2% to 54.1% at GGT-treated sites. These findings suggest that the GGTDBT stimulates the innate regenerative capacity of bone, supporting their use in bone tissue regeneration.

  7. Compositions, Formation Mechanism, and Neuroprotective Effect of Compound Precipitation from the Traditional Chinese Prescription Huang-Lian-Jie-Du-Tang

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    Chenze Zhang

    2016-08-01

    Full Text Available Compounds in the form of precipitation (CFP are universally formed during the decocting of Chinese prescriptions, such as Huang-Lian-Jie-Du-Tang (HLJDT. The formation rate of HLJDT CFP even reached 2.63% ± 0.20%. The identification by liquid chromatography mass spectrometry (LC-MSn proved that the main chemical substances of HLJDT CFP are baicalin and berberine, which is coincident with the theory that the CFP might derive from interaction between acidic and basic compounds. To investigate the formation mechanism of HLJDT CFP, baicalin and berberine were selected to synthesize a simulated precipitation and then the baicalin–berberine complex was obtained. Results indicated that the melting point of the complex interposed between baicalin and berberine, and the UV absorption, was different from the mother material. In addition, 1H-NMR integral and high-resolution mass spectroscopy (HR-MS can validate that the binding ratio was 1:1. Compared with baicalin, the chemical shifts of H and C on glucuronide had undergone significant changes by 1H-, 13C-NMR, which proved that electron transfer occurred between the carboxylic proton and the lone pair of electrons on the N atom. Both HLJDT CFP and the baicalin–berberine complex showed protective effects against cobalt chloride-induced neurotoxicity in differentiated PC12 cells. It is a novel idea, studying the material foundation of CFP in Chinese prescriptions.

  8. Alterations in Pharmacokinetics of Gemcitabine and Erlotinib by Concurrent Administration of Hyangsayukgunja-Tang, a Gastroprotective Herbal Medicine.

    Science.gov (United States)

    Kim, Tae Hwan; Shin, Soyoung; Kim, Sarah; Bulitta, Jürgen B; Weon, Kwon-Yeon; Joo, Sang Hoon; Ma, Eunsook; Yoo, Sun Dong; Park, Gi-Young; Kwon, Dong Rak; Jeong, Seok Won; Lee, Da Young; Shin, Beom Soo

    2017-09-10

    Gemcitabine and erlotinib are the chemotherapeutic agents used in the treatment of various cancers and their combination is being accepted as a first-line treatment of advanced pancreatic cancer. Hyangsayukgunja-tang (HYT) is a traditional oriental medicine used in various digestive disorders and potentially helpful to treat gastrointestinal adverse effects related to chemotherapy. The present study was aimed to evaluate the effect of HYT on the pharmacokinetics of gemcitabine and erlotinib given simultaneously in rats. Rats were pretreated with HYT at an oral dose of 1200 mg/kg/day once daily for a single day or 14 consecutive days. Immediately after pretreatment with HYT, gemcitabine and erlotinib were administered by intravenous injection (10 mg/kg) and oral administration (20 mg/kg), respectively. The effects of HYT on pharmacokinetics of the two drugs were estimated by non-compartmental analysis and pharmacokinetic modeling. The pharmacokinetics of gemcitabine and erlotinib were not altered by single dose HYT pretreatment. However, the plasma levels of OSI-420 and OSI-413, active metabolites of erlotinib, were significantly decreased in the multiple dose HYT pretreatment group. The pharmacokinetic model estimated increased systemic clearances of OSI-420 and OSI-413 by multiple doses of HYT. These data suggest that HYT may affect the elimination of OSI-420 and OSI-413.

  9. Chemomics-Integrated Proteomics Analysis of Jie-Geng-Tang to Ameliorate Lipopolysaccharide-Induced Acute Lung Injury in Mice

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    Jin Tao

    2016-01-01

    Full Text Available Jie-Geng-Tang (JGT, a classic and famous traditional Chinese medicine (TCM prescription composed of Platycodon grandiflorum (Jacq. A. DC. (PG and Glycyrrhiza uralensis Fisch. (GU, is well known for “clearing heat and relieving toxicity” and its ability to “diffuse the lung and relieve sore throat.” However, the mechanism underlying its action remains unclear. In this study, potential anti-inflammatory ingredients were screened and submitted to PharmMapper and the KEGG bioinformatics website to predict the target proteins and related pathways, respectively. Differentially expressed candidate proteins from acute lung injury (ALI mice treated with JGT were identified by isobaric tags for relative and absolute quantitation (iTRAQ and LC Triple-TOF. Eleven potential anti-inflammatory ingredients were found, including the derivatives of glycyrrhizic acid, licorice-saponin, liquiritin, and platycodigenin. A total of sixty-seven differentially expressed proteins were confirmed after JGT treatment with four therapeutic functions, including immunoregulation, anti-inflammation, ribosome, and muscle contraction. PG and GU comediate PI3K/Akt signal pathway inhibition of NF-κB, VCAM1, and ICAM1 release which primarily act on PI3K, PDK1, AKT, and GSK3β. GU markedly inhibits the ERK/MAPK signaling pathways and primarily acts on LCK, RAS, and MEK. A network was constructed using bioactive ingredients, targets, and pathways to determine the mechanism underlying JGT treatment of ALI.

  10. Correlative analysis of metabolite profiling of Danggui Buxue Tang in rat biological fluids by rapid resolution LC-TOF/MS.

    Science.gov (United States)

    Li, Chang-Yin; Qi, Lian-Wen; Li, Ping

    2011-04-28

    In this work, the metabolite profiles of Danggui Buxue Tang (DBT) in rat bile and plasma were qualitatively described, and the possible metabolic pathways of DBT were subsequently proposed. Emphasis was put on correlative analysis of metabolite profiling in different biological fluids. After oral administration of DBT, bile and plasma samples were collected and pretreated by solid phase extraction. Rapid resolution liquid chromatography coupled to time-of-flight mass spectrometry (RRLC-TOFMS) was used for characterization of DBT-related compounds (parent compounds and metabolites) in biological matrices. A total of 142 metabolites were detected and tentatively identified from the drug-containing bile and plasma samples. Metabolite profiling shows that rat bile contained relatively more glutathione-derived conjugates, more saponins compounds and more diverse forms of metabolites than urine. The metabolite profile in plasma revealed that glucuronide conjugates of isoflavonoids, dimmers, acetylcysteine conjugates and parent form of phthalides, as well as saponin aglycones were the major circulating forms of DBT. Collectively, the metabolite profile analysis of DBT in different biological matrices provided a comprehensive understanding of the in vivo metabolic fates of constituents in DBT. Copyright © 2011 Elsevier B.V. All rights reserved.

  11. Serum Metabolomic Characterization of Liver Fibrosis in Rats and Anti-Fibrotic Effects of Yin-Chen-Hao-Tang

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    Hongyang Zhang

    2016-01-01

    Full Text Available Yin-Chen-Hao-Tang (YCHT is a famous Chinese medicine formula which has long been used in clinical practice for treating various liver diseases, such as liver fibrosis. However, to date, the mechanism for its anti-fibrotic effects remains unclear. In this paper, an ultra-performance liquid chromatography-time-of-flight mass spectrometry (UPLC-TOF-MS-based metabolomic study was performed to characterize dimethylnitrosamine (DMN-induced liver fibrosis in rats and evaluate the therapeutic effects of YCHT. Partial least squares-discriminant analysis (PLS-DA showed that the model group was well separated from the control group, whereas the YCHT-treated group exhibited a tendency to restore to the controls. Seven significantly changed fibrosis-related metabolites, including unsaturated fatty acids and lysophosphatidylcholines (Lyso-PCs, were identified. Moreover, statistical analysis demonstrated that YCHT treatment could reverse the levels of most metabolites close to the normal levels. These results, along with histological and biochemical examinations, indicate that YCHT has anti-fibrotic effects, which may be due to the suppression of oxidative stress and resulting lipid peroxidation involved in hepatic fibrogenesis. This study offers new opportunities to improve our understanding of liver fibrosis and the anti-fibrotic mechanisms of YCHT.

  12. Activity-dependent branching ratios in stocks, solar x-ray flux, and the Bak-Tang-Wiesenfeld sandpile model

    Science.gov (United States)

    Martin, Elliot; Shreim, Amer; Paczuski, Maya

    2010-01-01

    We define an activity-dependent branching ratio that allows comparison of different time series Xt . The branching ratio bx is defined as bx=E[ξx/x] . The random variable ξx is the value of the next signal given that the previous one is equal to x , so ξx={Xt+1∣Xt=x} . If bx>1 , the process is on average supercritical when the signal is equal to x , while if bxmarket hypothesis.” For stock volumes, solar x-ray flux intensities, and the Bak-Tang-Wiesenfeld (BTW) sandpile model, bx is supercritical for small values of activity and subcritical for the largest ones, indicating a tendency to return to a typical value. For stock volumes this tendency has an approximate power-law behavior. For solar x-ray flux and the BTW model, there is a broad regime of activity where bx≃1 , which we interpret as an indicator of critical behavior. This is true despite different underlying probability distributions for Xt and for ξx . For the BTW model the distribution of ξx is Gaussian, for x sufficiently larger than 1, and its variance grows linearly with x . Hence, the activity in the BTW model obeys a central limit theorem when sampling over past histories. The broad region of activity where bx is close to one disappears once bulk dissipation is introduced in the BTW model—supporting our hypothesis that it is an indicator of criticality.

  13. The Conflict Argument of "Desire"between Tang Romance Studies and Taoism%唐代传奇文学与道教关于“人欲”的冲突

    Institute of Scientific and Technical Information of China (English)

    崔明明

    2014-01-01

    Tang Romance Novels are symbolized the maturity of Chinese classical novels .As the wide-spread of Taoist culture ,Tang Romance absorbed Taoist culture .And on the one hand they also make full use of their advantages to present Taoism ,by showing people their unique life that lived in Tang Dynasty . Taoism ,as an indigenous religion ,its theory combined with Tang romance stories ,too .With the help of the tang literary genre ,it is easy to understand the Taoist esoteric knowledge and conception .Even Tang romance stories and Taoism have multiple relationships ,they still have conflict about "Desire":Taoism has thought of abstinence ,while in the literature of Tang romance stories it has more humanity and inspi-rations .%唐传奇是中国文言小说成熟的标志。作为道教文化的宣传者,唐传奇吸收道教的文化底蕴,一方面充分运用自身的优势阐释道教思想,另一方面展现了自身的独特生机。道教作为本土宗教,其理论与唐传奇紧密结合,道家深奥的学问借助唐传奇的文学体裁得以通俗易懂地展现。唐传奇与道教有着多重关系,除了互利的方面外,道教具有禁欲思想,而作为文学,唐传奇具有人文情怀和启迪作用,二者在宣传“人欲”方面存在冲突。

  14. Changes in urinary Cu, Zn, and Se levels in cancer patients after treatment with Sha Shen Mai Men Dong Tang

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    Tung-Yuan Lai

    2016-04-01

    Full Text Available Sha Shen Mai Men Dong Tang (SMD-2; 沙參麥冬湯 shā shēn mài dōng tāng is a Chinese medicinal herb (CMH; 中草藥 zhōng cǎo yào used to treat symptoms associated with cancer therapy. The objective of this study was to assess the effect of SMD-2 on the levels of urinary copper (Cu, zinc (Zn, and selenium (Se in lung cancer patients and head and neck cancer patients receiving chemoradiotherapy. Forty-two head and neck cancer patients and 10 lung cancer patients participated in our clinical trial. Each patient received chemoradiotherapy for 4 weeks. In addition, each patient was treated with SMD-2 for 8 weeks, including 2 weeks prior to and after the chemoradiotherapy treatment. Comparison of urinary Cu, Zn, and Se levels and the ratios of Zn to Cu and Se to Cu at three time points in the two types of cancer were assessed using the generalized estimating equations (GEEs. After the patients received chemoradiotherapy for 4 weeks, SMD-2 treatment was found to be associated with a significant decrease in urinary Cu levels, whereas urinary Zn and Se levels increased significantly. In addition, the ratios of Zn to Cu and Se to Cu in the urine samples of these patients also increased significantly. Both the urinary Zn levels and the ratio of Zn to Cu in head and neck cancer patients were significantly higher than in lung cancer patients. Urinary Zn and Se levels and the ratios of Zn to Cu and Se to Cu, but not urinary Cu levels, increased significantly during and after treatment when assessed using the GEE model. The SMD-2 treatments significantly increased Zn and Se levels in the urine of head and neck cancer patients. Increased Zn and Se levels in urine strengthened immune system.

  15. The effects of venting and decompression on Yellow Tang (Zebrasoma flavescens in the marine ornamental aquarium fish trade

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    Emily S. Munday

    2015-02-01

    Full Text Available Each year, over 45 countries export 30 million fish from coral reefs as part of the global marine ornamental aquarium trade. This catch volume is partly influenced by collection methods that cause mortality. Barotrauma in fish resulting from forced ascent from depth can contribute to post-collection mortality. However, implementing decompression stops during ascent can prevent barotrauma. Conversely, venting (puncturing the swim bladder to release expanded internal gas following ascent can mitigate some signs of barotrauma like positive buoyancy. Here, we evaluate how decompression and venting affect stress and mortality in the Yellow Tang (Zebrasoma flavescens. We examined the effects of three ascent treatments, each with decompression stops of varying frequency and duration, coupled with or without venting, on sublethal effects and mortality using histology and serum cortisol measurements. In fish subjected to ascent without decompression stops or venting, a mean post-collection mortality of 6.2% occurred within 24 h of capture. Common collection methods in the fishery, ascent without decompression stops coupled with venting, or one long decompression stop coupled with venting, resulted in no mortality. Histopathologic examination of heart, liver, head kidney, and swim bladder tissues in fish 0d and 21d post-collection revealed no significant barotrauma- or venting-related lesions in any treatment group. Ascent without decompression stops resulted in significantly higher serum cortisol than ascent with many stops, while venting alone did not affect cortisol. Future work should examine links in the supply chain following collection to determine if further handling and transport stressors affect survivorship and sublethal effects.

  16. Activity-dependent branching ratios in stocks, solar x-ray flux, and the Bak-Tang-Wiesenfeld sandpile model.

    Science.gov (United States)

    Martin, Elliot; Shreim, Amer; Paczuski, Maya

    2010-01-01

    We define an activity-dependent branching ratio that allows comparison of different time series X(t). The branching ratio b(x) is defined as b(x)=E[xi(x)/x]. The random variable xi(x) is the value of the next signal given that the previous one is equal to x, so xi(x)=[X(t+1) | X(t)=x]. If b(x)>1, the process is on average supercritical when the signal is equal to x, while if b(x)efficient market hypothesis." For stock volumes, solar x-ray flux intensities, and the Bak-Tang-Wiesenfeld (BTW) sandpile model, b(x) is supercritical for small values of activity and subcritical for the largest ones, indicating a tendency to return to a typical value. For stock volumes this tendency has an approximate power-law behavior. For solar x-ray flux and the BTW model, there is a broad regime of activity where b(x) approximately equal 1, which we interpret as an indicator of critical behavior. This is true despite different underlying probability distributions for X(t) and for xi(x). For the BTW model the distribution of xi(x) is Gaussian, for x sufficiently larger than 1, and its variance grows linearly with x. Hence, the activity in the BTW model obeys a central limit theorem when sampling over past histories. The broad region of activity where b(x) is close to one disappears once bulk dissipation is introduced in the BTW model-supporting our hypothesis that it is an indicator of criticality.

  17. Development of Simultaneous Analysis of Thirteen Bioactive Compounds in So-Cheong-Ryong-Tang Using UPLC-DAD

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    Ji Hyun Jeong

    2018-01-01

    Full Text Available So-Cheong-Ryong-Tang, which is a standardized Korean medicine of the National Health Insurance, is a traditional prescription for the treatment of allergic rhinitis, bronchitis, and bronchial asthma. Simultaneous analysis and development of SCRT is essential for its stability, efficacy, and risk management. In this study, a simple, reliable, and accurate method using ultrahigh-performance liquid chromatography (UPLC fingerprinting with a diode array detector (DAD was developed for the simultaneous analysis. The chromatographic separation of the analytes was performed by an ACQUITY UPLC BEH C18 column (1.7 μM, 2.1 × 100 mm, Waters with a mobile phase of water containing 0.01% (v/v phosphoric acid and acetonitrile containing 0.01% (v/v phosphoric acid. The flow rate and detection wavelength were set at 0.4 mL/min and 215, 230, 254, and 280 nm. All calibration curves of the thirteen components showed good linearity (R2 > 0.999. The limit of detection and limit of quantification ranged 0.001–0.360 and 0.004–1.200 µg/mL, respectively. The relative standard deviation (RSD of intra- and interday was less than 2.60%, and the recoveries were within the range 76.08–103.79% with an RSD value of 0.03–1.50%. The results showed that the developed method was simple, reliable, accurate, sensitive, and precise for the quantification of bioactive components of SCRT.

  18. Fysisk träning som vård av muskuloskeletala störningar bland datorarbetande : - en litteraturöversikt

    OpenAIRE

    Renvall, Ralf

    2010-01-01

    Sammandrag: Ämnet för denna litteraturöversikt är fysisk träning som vård av muskuloskeletala funktionsstörningar bland datorarbetande. Dessa arbetsrelaterade muskuloskeletala funktionsstörningar är mycket vanliga. Arbetsförhållandena nuförtiden gör att tiden som används vid datorn förlängs och att minska belastningen med endast rätt arbetsergonomi kan orsaka andra problem. Förlängda arbetspass, låg variation i muskelns kontraktionsnivå och ökad monotoni kan bli följden av optimerad erg...

  19. Yongdamsagan-tang, a traditional herbal formula, inhibits cell growth through the suppression of proliferation and inflammation in benign prostatic hyperplasia epithelial-1 cells.

    Science.gov (United States)

    Park, Eunsook; Lee, Mee-Young; Seo, Chang-Seob; Jeon, Woo-Young; Shin, Hyeun-Kyoo

    2017-09-14

    Benign prostatic hyperplasia (BPH), also called benign enlargement of the prostate, is a progressive disease that is observed in most elderly men. Yongdamsagan-tang, a traditional herbal formula, is used commonly for the treatment of inflammation-related diseases. Although the therapeutic efficacy of Yongdamsagan-tang against BPH in vivo was reported previously, its underlying mechanisms are not clearly understood. In this study, we investigated the effect of Yongdamsagan-tang water extract (YSTE) and its mechanism on the growth of human BPH epithelial BPH-1 cells. YSTE was extracted from 11 herbaceous plants and its chemical composition was analyzed by High-performance liquid chromatography (HPLC). YSTE was treated in the epithelial BPH-1 cell line and then cell lysates or supernant were used to evaluate cell viability, cell cycle, proliferation and cytokine production. HPLC revealed that Baicalin and gentiopicroside were involved as the major compounds of YSTE. YSTE treatment in BPH-1 cells repressed cell viability in a dose-dependent manner. Regarding the inhibitory mechanisms of YSTE on cell growth, YSTE inhibited cell proliferation via a decrease in endogenous cyclin D1 protein levels and arrest at the S phase during cell-cycle progression. Furthermore, YSTE treatment in BPH-1 cells suppressed prostaglandin E 2 production and cyclooxygenase-2 (COX-2) protein levels. The secretion of the proinflammatory cytokines, interleukin-8 and interleukin-6, was also reduced by YSTE treatment. YSTE in BPH-1 cells showed antiproliferative and anti-inflammatory activities via cell-cycle arrest and downregulation of COX-2 expression, respectively. Taken together, the results of the present study will enhance our understanding of the mechanisms underlying the effect of YSTE in BPH. Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.

  20. Effects of Gui Zhi Ma Huang Ge Ban Tang on the TLR7 Pathway in Influenza Virus Infected Mouse Lungs in a Cold Environment.

    Science.gov (United States)

    Qin, Hong-Qiong; Shi, Shan-Shan; Fu, Ying-Jie; Yan, Yu-Qi; Wu, Sha; Tang, Xiao-Long; Chen, Xiao-Yin; Hou, Guang-Hui; Jiang, Zhen-You

    2018-01-01

    We wished to investigate the effects of the traditional Chinese medicine Gui Zhi Ma Huang Ge Ban Tang on controlling influenza A virus (IAV) infection and improving inflammation in mouse lungs. Mice were maintained in normal and cold environments and infected with IAV by intranasal application, respectively. Real-time quantitative polymerase chain reaction was used to measure mRNA expression of TLR7, myeloid differentiation primary response 88 (MyD88), and nuclear factor-kappa B (NF- κ B)p65 in the TLR7 signaling pathway and virus replication in lungs. Western blotting was used to measure expression levels of TLR7, MyD88, and NF- κ B p65 proteins. Flow cytometry was used to detect the proportion of T-helper (Th)1/Th2 and Th17/T-regulatory (Treg) cells. Application of Gui Zhi Ma Huang Ge Ban Tang in influenza-infected mice in a cold environment showed (i) downregulation of TLR7, MyD88, and NF- κ Bp65; (ii) inhibition of transcriptional activities of promoters coding for TLR7, MyD88, and NF- κ Bp65; (iii) reduction in the proportion of Th1/Th2 and Th17/Treg cells. Gui Zhi Ma Huang Ge Ban Tang had a good therapeutic effect on mice infected with IAV, especially in the cold environment. It could reduce lung inflammation in mice significantly and elicit an anti-influenza effect by downregulating expression of the key factors in TLR7 signaling pathway.

  1. Improving cachectic symptoms and immune strength of tumour-bearing mice in chemotherapy by a combination of Scutellaria baicalensis and Qing-Shu-Yi-Qi-Tang.

    Science.gov (United States)

    Wang, Hang; Chan, Yi-Lin; Li, Tsung-Lin; Wu, Chang-Jer

    2012-05-01

    Cancer cachexia is characterised by the loss of body mass and directly compromises immune response and the quality of life of cancer patients. In the present study, we set out to investigate the role of Chinese herbs as anticancer medicines and/or chemotherapeutic adjuvants to increase therapeutic efficacy and/or ameliorate given side-effects in animal model. Twelve kinds of herbs were chosen from the ingredients of major Chinese herbal medicines, and their effects on the antioxidant activity were investigated. To obtain the anticancer effects of 5-fluorouracil (5-FU) when consumed with minimal side-effects, we investigated the combination effect of Scutellaria baicalensis and Qing-Shu-Yi-Qi-Tang that may enhance the anticancer activity of 5-FU on subcutaneous tumour growth in C57BL/6 mice challenged with Lewis lung carcinoma cells. Qing-Shu-Yi-Qi-Tang, a multiple-component herbal extract, was shown to have high anti-oxidation activity, while S. baicalensis (Chinese skullcap) was demonstrated to have high tumour-growth inhibition activity. Thus, S. baicalensis and Qing-Shu-Yi-Qi-Tang were evaluated for their combinaton effects on the cancer-induced cachectic murine upon receiving 5-FU chemotherapy. As a result, tumour masses and losses of carcass and/or gastrocnemius muscle were found to be significantly decreased. This combination otherwise increased both Th1/Th2 ratio and NK cytotoxicity. In the mice receiving with or without 5-FU, the serum levels of monocyte chemoattractant protein-1 (MCP-1) increased by all means but otherwise decreased when the herbal combination was administrated. Additionally, the expressions of nuclear factor-kappa B (NF-κB) and muscle RING finger protein-1 (MuRF-1) decreased in the gastrocnemius muscle when the herbal combination was applied. Our results revealed that the combination of S. baicalensis and Qing-Shu-Yi-Qi-Tang is able to ameliorate cachectic symptoms and positively stimulate anti-tumour immunity while undergoing

  2. Monographs in Tang Official Historiography: Perspectives from the Technical Treatises of the History of Sui (Sui shu)

    OpenAIRE

    Morgan, Daniel Patrick; Chaussende, Damien

    2018-01-01

    Finished in 656 as part of a larger project, the ten ‘treatises’ (zhi) of the current History of Sui (Sui shu) provide us with histories of such fields of technical knowledge as astronomy, astrology, omenology, economics, law, geography, metrology, and library science covering the five divided and short-lived dynasties, 502–618 CE, that were the predecessors of the Tang. This edited volume brings together young experts in these fields to reflect upon the way that their history has been writte...

  3. Simultaneous use of traditional Chinese medicine (Si-Ni-Tang to treat septic shock patients: study protocol for a randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Wu Shin-Hwar

    2011-08-01

    Full Text Available Abstract Background Even though there are continually upgraded recommendations for managing sepsis, such as "Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock", mortality is still high. Si-Ni-Tang, a remedy documented in Shanghan Lun, a medical collection from ancient China, is used for treating patients with sepsis and septic shock. Using a well-designed clinical trial, we are eager to survey the effectiveness of the concurrent use of this remedy in restoring these patients' hemodynamic status, or "Yang Qi". Methods/Design Patients admitted to our medical intensive care units with the diagnosis of septic shock, defined as persistent hypotension induced by sepsis despite adequate fluid resuscitation, are eligible for participation. The inclusion criteria include: age from 20 to 85 years, conditions meeting the definition of septic shock, use of vasopressors within 24 hours of entering the study, and use of a nasogastric tube for feeding. The enrolled patients are randomly allocated either to the Si-Ni-Tang group or the placebo group. The prescription of the trial drugs (Si-Ni-Tang/placebo is 2.25 grams 4 times a day for 7 days or till shock reversal (if shock reversal occurs in less than 7 days. Data, including duration of vasopressor infusion, gender, age, co-morbidities, APACHE II score, predicted mortality, ICU mortality, ICU length of stay, hospital mortality, hospital length of stay, source of sepsis, and culture results, are collected for the following analysis. Discussion Si-Ni-Tang is composed of processed Zingiber officinale, Glycyrrhiza uralensis, and Aconitum carmichaeli. Zingiber officinale and Glycyrrhiza uralensis are found to have the ability to reduce pro-inflammatory cytokine production, to inhibit lipopolisaccharide-induced macrophage activation and function, and to lessen the bacterial load and suppress acute and chronic inflammation. Aconitum carmichaeli is known to have

  4. The Study on the Composition of Yongdamsagan-tang(龍膽瀉肝湯’s Essential Oil Obtained by Supercritical Carbon Dioxide Extraction

    Directory of Open Access Journals (Sweden)

    Shin Min-Seop

    2008-03-01

    Full Text Available Objectives : This study was performed to analyze the effective components of essential oil obtained from Yongdamsagan-tang, which has been efficacious against leukorrhea in gynecologic diseases. Methods : I obtained the essential oils of Yongdamsagan-tang by hydrodistillation extraction method and supercritical fluid extraction(SFE method, and then I analyzed those by GC/MS(Gas Chromatography/Mass Spectrum. Results : 1. The optimum SFE(Supercritical Fluid Extraction condition was obtained in the following experiment conditions: pressure 200atm, temperature 45℃, duration of extraction 25minutes. 2. With GC(Gas Chromatography and GC/MS(Gas Chromato- graphy/Mass Spectrum analysis, I identified 37 compounds in the Yongdamsagan-tang's essential oil obtained through the SFE method. The main compounds were as follows : 3-Methyl-but-2-enoic acid,2,2-dimethyl-8-oxo-3,4-dihydro-2H,8H -pyrano[3,2-g]chromen-3-yl ester(49.81 %, (Z-6-Pentadecen-1 -ol(3.19%, (--Spathulenol(2.40%. 3. I identified 4 compounds in the Yongdamsagan-tang's essential oil obtained through the hydrodistillation method. The main compounds were as follows : 3-Methyl-but-2-enoic acid, 2,2-dimethyl-8-oxo-3,4-dihydro-2H,8H-pyrano[3,2-g]chromen-3-yl ester(2.61%. 4. 3 - Methy l - but - 2 - enoic acid, 2, 2 - dimethyl - 8 - oxo - 3, 4 - dihydro - 2H, 8H - pyrano[3, 2 - g] chromen - 3 - yl ester, all were identified in both the SFE method and the hydrodistillation method, but the others were not identified in common. 5. I also conducted an additional test in order to examine the essential oil's antimicrobial action against bacteria. Both MIC(Minimum Inhibitory Concentrations and MBC(Minimum Bactericidal Concentrations were 0.125㎎/㎖ against N. meningitidis, however MIC and MBC were 1.0㎎/㎖ in antimicrobial action against 12 different genera of bacteria.

  5. Amelioration of inflammatory responses by Socheongryong-Tang, a traditional herbal medicine, in RAW 264.7 cells and rats

    Science.gov (United States)

    Kim, Youn Sook; Jung, Ji Yun; Park, Chung A.; Jegal, Kyung Hwan; Ku, Sae Kwang; Kim, Jae Kwang; Lee, Chul Won; Kim, Young Woo; Cho, Il Je; An, Won G.; Kim, Sang Chan

    2018-01-01

    Socheongryong-Tang (SCRT) is a natural medicine prescription that has been mainly used in East Asia for the treatment of inflammatory disorders, including asthma and allergic rhinitis. The present study evaluated the anti-inflammatory effects of SCRT on lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and in a rat model of carrageenan (CA)-induced paw edema. Levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6 and prostaglandin E2 (PGE2) in the culture supernatant were quantified and nitric oxide (NO) production was monitored. In addition, the effect of SCRT on the protein expression of nuclear factor-κB (NF-κB), mitogen-activated protein kinases (MAPKs), inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) was assessed by western blot analysis. Furthermore, the effects of SCRT on acute inflammation in vivo and changes in the histomorphometry and histopathology of paw skin were observed using CA-treated rats. SCRT (1 mg/ml) inhibited the LPS-induced changes in the protein expression of NF-κB, JNK, ERK1/2, iNOS and COX-2, as well as the production of NO, PGE2 and cytokines. In the rat paw edema assay, administration of 1 g/kg of lyophilized powder obtained from the aqueous extracts of SCRT for 3 consecutive days inhibited the CA-induced increases in skin thickness, mast cell degranulation, and infiltration of inflammatory cells in the ventral and dorsal pedis skin within 4 h. These results demonstrated that SCRT exerts its anti-inflammatory activities in LPS-stimulated RAW 264.7 cells through decreasing the production of inflammatory mediators, including PGE2, NO and cytokines, via suppression of the NF-κB and JNK and ERK1/2 signaling pathways. In addition, the data of the CA-induced paw edema indicated an anti-edema effect of SCRT. SCRT (1 g/kg) reduced acute edematous inflammation through inhibition of mast cell degranulation and infiltration of inflammatory cells. Therefore, the present study provided scientific evidence for the

  6. Xiao-Qing-Long-Tang shows preventive effect of asthma in an allergic asthma mouse model through neurotrophin regulation

    Science.gov (United States)

    2013-01-01

    Background This study investigates the effect of Xiao-Qing-Long-Tang (XQLT) on neurotrophin in an established mouse model of Dermatophagoides pteronyssinus (Der p)-induced acute allergic asthma and in a LA4 cell line model of lung adenoma. The effects of XQLT on the regulation of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), airway hyper-responsiveness (AHR) and immunoglobulin E were measured. Methods LA4 cells were stimulated with 100 μg/ml Der p 24 h and the supernatant was collected for ELISA analysis. Der p-stimulated LA4 cells with either XQLT pre-treatment or XQLT co-treatment were used to evaluate the XQLT effect on neurotrophin. Balb/c mice were sensitized on days 0 and 7 with a base-tail injection of 50 μg Dermatophagoides pteronyssinus (Der p) that was emulsified in 50 μl incomplete Freund’s adjuvant (IFA). On day 14, mice received an intra-tracheal challenge of 50 μl Der p (2 mg/ml). XQLT (1g/Kg) was administered orally to mice either on days 2, 4, 6, 8, 10 and 12 as a preventive strategy or on day 15 as a therapeutic strategy. Results XQLT inhibited expression of those NGF, BDNF and thymus-and activation-regulated cytokine (TARC) in LA4 cells that were subjected to a Der p allergen. Both preventive and therapeutic treatments with XQLT in mice reduced AHR. Preventive treatment with XQLT markedly decreased NGF in broncho-alveolar lavage fluids (BALF) and BDNF in serum, whereas therapeutic treatment reduced only serum BDNF level. The reduced NGF levels corresponded to a decrease in AHR by XQLT treatment. Reduced BALF NGF and TARC and serum BDNF levels may have been responsible for decreased eosinophil infiltration into lung tissue. Immunohistochemistry showed that p75NTR and TrkA levels were reduced in the lungs of mice under both XQLT treatment protocols, and this reduction may have been correlated with the prevention of the asthmatic reaction by XQLT. Conclusion XQLT alleviated allergic inflammation including AHR, Ig

  7. Control of stress-induced depressive disorders by So-ochim-tang-gamibang, a Korean herbal medicine.

    Science.gov (United States)

    Choi, Jung Eun; Park, Dae-Myung; Chun, Eunho; Choi, Jeong June; Seo, Ji Hye; Kim, Seunghyung; Son, Jaemin; Do, Moonho; Kim, Sun Yeou; Park, Yang-Chun; Jung, In Chul; Jin, Mirim

    2017-01-20

    So-ochim-tang-gamibang (SOCG) is a Korean herbal medicine formula that has been applied to treat depressive moods and depression associated somatoform pain. This decoction consists of Cyperus rotundus L. (Cyperi Rhizoma), Lindera aggregata (Sims) Kosterm. (Linderae Radix), Aquilaria agallochum (Lour.) Roxb. ex Finl. (Aquilariae Resinatum Lignum), Glycyrrhiza uralensis Fisch. (Glycyrrhizae Radix) Platycodon grandiflorum (Jacq.) A. DC. (Platycodi Radix), and Citrus aurantium L. (Aurantii Fructus). The aim of this study is to assess antidepressant-like effects of SOCG and to investigate its possible cellular and molecular mechanisms. Using chronic restraint stress animal model, effects of SOCG on depressive-like behaviors, corticosterone, and hippocampal expressions of a neurotrophic factor and an apoptotic marker, were investigated. Mice were exposed to restraint stress 6h per day over a period of two weeks, and orally administrated either SOCG (30, 100, or 300mg/kg/day). The depressive-like behaviors were analyzed by forced swimming test and open field test. The serum levels of corticosterone were measured by enzyme-linked immunosorbent assay. Expressions of caspase-3 and BDNF in the hippocampus were analyzed by immunofluorescence. Further, effects of SOCG were examined in corticosterone-treated PC12 cells. Cellular toxicity was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and lactate dehydrogenase assays. Real-time PCR was applied to investigate the cellular expression levels of Bax, Bcl-2, and BDNF. The levels of caspase-3 and BDNF were examined by Western blotting. Administration of SOCG not only reduced immobility time of restraint-stressed mice in a dose-dependent manner, but also significantly increased the distance mice moved and the number of crossings in the open field test. Further, SOCG significantly reduced the serum level of corticosterone and expression of caspase-3, while increased expression of BDNF in vivo. SOCG

  8. A divulgação dos ativos fixos tangíveis segundo a IAS 16 e o seu grau de cumprimento

    Directory of Open Access Journals (Sweden)

    Fernando Jorge Ferreira da Costa

    2015-12-01

    Full Text Available Este estudo analisa o grau do cumprimento das divulgações da International Accounting Standard 16 “Ativos Fixos Tangíveis” no Anexo às demonstrações financeiras consolidadas das empresas cotadas na Euronext Lisboa, no período de 2005-2010, bem como sua evolução e determinação dos potenciais fatores corporativos explicativos desse grau de cumprimento. Utilizando um índice de cumprimento, constatou-se um grau de cumprimento médio intermédio dos requisitos de divulgação da IAS 16 (67,3%. A experiência na aplicação das normas apresentou um impacto positivo, apesar de ligeiro. Atendendo à revisão da literatura e aos argumentos da teoria da agência, teoria dos custos políticos, teoria da sinalização e teoria da necessidade de capital foram desenvolvidas seis hipóteses explicativas do grau de cumprimento mencionado. Os resultados evidenciam que o tamanho da empresa e o montante de ativos fixos tangíveis são fatores corporativos explicativos do grau de cumprimento dos requisitos da divulgação previstos na IAS 16.

  9. Phylogenetic relationships of Hemiuridae (Digenea: Hemiuroidea) with new morphometric and molecular data of Aphanurus mugilis Tang, 1981 (Aphanurinae) from mullet fish of Vietnam.

    Science.gov (United States)

    Atopkin, D M; Besprozvannykh, V V; Yu Beloded, A; Ngo, H D; Ha, N V; Tang, N V

    2017-12-01

    Adult Aphanurus mugilis Tang, 1981 worms were detected in the intestine of Moolgarda engeli in the shallow waters off Cat Ba Island, Vietnam. Tang (1981) first described this species in Mugil cephalus off China. The worms in Vietnamese mullet were identical to Chinese specimens in a number of morphometric characteristics, with the exception of body and ovary size. In the present study, morphological characteristics, and the first molecular data for A. mugilis are provided. Additionally, molecular phylogenetic analysis of the family Hemiuridae was performed. The results of our molecular phylogenetic study indicate that the presence or absence of an ecsoma was not associated with molecular data for hemiurid subfamilies differentiation. The basal position of Bunocotylinae on the molecular-based phylogenetic tree indicated a primordial nature of ecsoma of hemiurid trematodes. Considerable molecular differentiation of Bunocotylinae from other hemiurids indicated the possibility of the recognition of the family Bunocotylidae Dollfus, 1950. Assuming that Machidatrema chilostoma is considered within the Bunocotylinae, the paraphyly of the Lecithasterinae was supported. Copyright © 2017 Elsevier B.V. All rights reserved.

  10. Optimization of high pressure machine decocting process for Dachengqi Tang using HPLC fingerprints combined with the Box–Behnken experimental design

    Directory of Open Access Journals (Sweden)

    Rui-Fang Xie

    2015-04-01

    Full Text Available Using Dachengqi Tang (DCQT as a model, high performance liquid chromatography (HPLC fingerprints were applied to optimize machine extracting process with the Box–Behnken experimental design. HPLC fingerprints were carried out to investigate the chemical ingredients of DCQT; synthetic weighing method based on analytic hierarchy process (AHP and criteria importance through intercriteria correlation (CRITIC was performed to calculate synthetic scores of fingerprints; using the mark ingredients contents and synthetic scores as indicators, the Box–Behnken design was carried out to optimize the process parameters of machine decocting process under high pressure for DCQT. Results of optimal process showed that the herb materials were soaked for 45 min and extracted with 9 folds volume of water in the decocting machine under the temperature of 140 °C till the pressure arrived at 0.25 MPa; then hot decoction was excreted to soak Dahuang and Mangxiao for 5 min. Finally, obtained solutions were mixed, filtrated and packed. It concluded that HPLC fingerprints combined with the Box–Behnken experimental design could be used to optimize extracting process of traditional Chinese medicine (TCM. Keywords: Dachengqi Tang, HPLC fingerprints, Box–Behnken design, Synthetic weighing method

  11. En sammenlignende undersøgelse af praktikforløb og færdighedstræning i tre videregående uddannelser

    Directory of Open Access Journals (Sweden)

    Anne Mette Mørcke

    2015-03-01

    Full Text Available Praktikforløb i videregående uddannelser er blevet et politisk indsatsområde, og der er i sundhedsuddannelserne også et internationalt forskningsfokus på emnet. I denne artikel vil vi beskrive og sammenligne rammerne for praktikforløb og færdighedstræning på idræts-, læge- og sygeplejerskeuddannelsen. Artiklen tager afsæt i Heggens skelnen mellem begreberne professionsidentitet og professionel identitet. Den studerendes opfattelse af sig selv som professionsudøver må ud fra dette afsæt udvikles via tilegnelse af både en særlig videnskabelig funderet teoretisk viden, særlig praktisk ekspertise, samt en særlig etisk og social forpligtelse til at arbejde for medborgernes bedste. I den konkrete sammenligning af idræts-, læge- og syge-plejerskeuddannelserne konkluderes, at både færdighedstræning og praktik vægtes højt, men at både omfang, struktur, placering og læringsmål varierer betydeligt. Det må have væsensforskellige konsekvenser for de studerendes tilegnelse af viden, færdigheder og holdninger og dermed for deres professionelle identitetsudvikling. Vi kan ikke afgøre om professionsidentitetsforståelsen er årsag eller virkning, men der ser ud til at være et samspil mellem uddannelsernes undervisningsformer og professionsidentitet.   In this paper we describe and compare workplace learning and skills training in medicine, nursing and sports science education. The paper builds on Heggen’s concepts concerning the identity of a profession versus a personal professional identity. Based on this, a student’s perception of herself as a professional develops from learning a particular scientific knowledge-base, a particular set of practical skills and a particular ethical and social obligation to work for the community. We concluded that all three educations studied attach great importance to workplace learning and skills training, but the extent, the structure, the timing and the learning outcomes differ

  12. Uue aja ning formaadi biennaalid

    Index Scriptorium Estoniae

    2001-01-01

    Phaidron Press Ltd. väljaandena ilmunud raamatus "Fresh Cream. Contemporary Art in Culture" on kümne kuraatori valitud saja 1990-ndate kunsti mõjutanud kunstniku seas Jaan Toomik (Viktor Misiano valik). Raamatu võrdlus 1998. a. ilmunud "Cream'iga". 1998. a. ja 2000. a. kuraatorid, võtmekirjutajad

  13. Collaborative Lea(r)ning

    DEFF Research Database (Denmark)

    Nielsen, Jacob S.

    The inter-organisational collaboration perspective is not new. Phoenician merchants have used this perspective while setting up joint ventures to limit their risks in overseas trading. What is new are the ways in which efficiency alliances are interacting and changing the terms of competition, th...... as more floating. Companies in network have to understand that the success of every single company depends on the performance of every single partner in the network. The actors in the network must construct a mutual win-win situation for everybody. One of the first steps to accomplish...... systems to work together closely. Although only limited research has been done in this area it is clear that creating a joint improvement and learning culture between organisations is not easy. One of the first major step to explore this field was started in 2001 when a three year EU-funded project...

  14. Impact of parameter fluctuations on the performance of ethanol precipitation in production of Re Du Ning Injections, based on HPLC fingerprints and principal component analysis.

    Science.gov (United States)

    Sun, Li-Qiong; Wang, Shu-Yao; Li, Yan-Jing; Wang, Yong-Xiang; Wang, Zhen-Zhong; Huang, Wen-Zhe; Wang, Yue-Sheng; Bi, Yu-An; Ding, Gang; Xiao, Wei

    2016-01-01

    The present study was designed to determine the relationships between the performance of ethanol precipitation and seven process parameters in the ethanol precipitation process of Re Du Ning Injections, including concentrate density, concentrate temperature, ethanol content, flow rate and stir rate in the addition of ethanol, precipitation time, and precipitation temperature. Under the experimental and simulated production conditions, a series of precipitated resultants were prepared by changing these variables one by one, and then examined by HPLC fingerprint analyses. Different from the traditional evaluation model based on single or a few constituents, the fingerprint data of every parameter fluctuation test was processed with Principal Component Analysis (PCA) to comprehensively assess the performance of ethanol precipitation. Our results showed that concentrate density, ethanol content, and precipitation time were the most important parameters that influence the recovery of active compounds in precipitation resultants. The present study would provide some reference for pharmaceutical scientists engaged in research on pharmaceutical process optimization and help pharmaceutical enterprises adapt a scientific and reasonable cost-effective approach to ensure the batch-to-batch quality consistency of the final products. Copyright © 2016 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.

  15. Quality evaluation of Guan-Xin-Ning injection based on fingerprint analysis and simultaneous separation and determination of seven bioactive constituents by capillary electrophoresis.

    Science.gov (United States)

    Xu, Liying; Chang, Ruimiao; Chen, Meng; Li, Lou; Huang, Yayun; Zhang, Hongfen; Chen, Anjia

    2017-12-01

    The purpose of this study was to develop a comprehensive, rapid and practical capillary electrophoresis (CE) method for quality control (QC) of Guan-Xin-Ning (GXN) injection based on fingerprint analysis and simultaneous separation and determination of seven constituents. In fingerprint analysis, a capillary zone electrophoresis (CZE) method with a running buffer of 30 mM borate solution (pH 9.3) was established. Meanwhile, ten batches of samples were used to establish the fingerprint electropherogram and 34 common peaks were obtained within 20 min. The RSD of relative migration times (RMT) and relative peak areas (RPA) were less than 5%. In order to further evaluate the quality of GXN injection, a micellar electrokinetic chromatography (MEKC) method was developed for simultaneous separation and determination of bioactive constituents. Seven components reached baseline separation with a running buffer containing 35 mM SDS and 45 mM borate solution (pH 9.3). A good linearity was obtained with correlation coefficients from 0.9906 to 0.9997. The LOD and LOQ ranged from 0.12 to 1.50 μg/mL and from 0.40 to 4.90 μg/mL, respectively. The recoveries ranged between 99.0 and 104.4%. Therefore, it was concluded that the proposed method can be used for full-scale quality analysis of GXN injection. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. Eesti riigi esindamine Euroopa Liidu Kohtus - Eestit puudutavate ja võimalike ees ootavate vaidluste ning Eesti seiuskohtade juriidiline analüüs : [magistritöö] / Katri Bagirov ; Tartu Ülikool, õigusteaduskond ; juhendaja: Julia Laffranque

    Index Scriptorium Estoniae

    Bagirov, Katri

    2010-01-01

    Eesti riigi esindamisest ELi Kohtus, esindamise korrast ja eelmenetlusest. Eesti edukusest Euroopa Liidu õiguse ülevõtmisel ning mõjutamisel ja kujundamisel, analüüsist läbi kohtupraktika. Eesti riigi esindamisega seotud probleemide juriidilisest analüüsist

  17. Sõnumisaladuse kaitse tööandjale kuuluvate sidevahendite kasutamisel ning karistusõiguslik vastutus selle õiguse rikkumisel : [magistritöö] / Olev Kirst ; Tartu Ülikool, õigusteaduskond ; juhendaja: Jaan Ginter

    Index Scriptorium Estoniae

    Kirst, Olev

    2012-01-01

    Põhimõistete määratlemisest, sõnumisaladuse kaitse piiridest, sõnumite jälgimise vajadusest ja ulatusest, tööandja sidevahendite jälgimise õiguslikest alustest ja põhimõtetest ning praktikast, karistusõiguslikust vastutusest sõnumisaladuse rikkumisel ja kohtupraktikast (Eesti, Soome, Saksamaa, Venemaa)

  18. Tõrjuv kahjuhüvitis Eesti ja Saksa võlaõiguses mittevaralise kahju hüvitamisel ning selle seos karistusliku kahjuhüvitise kontseptsiooniga / Martin Hirvoja

    Index Scriptorium Estoniae

    Hirvoja, Martin, 1977-

    2011-01-01

    Mittevaraliste õiguste kaitsest põhiseaduses ning isikuõiguse võlaõiguslikust mõistest. Karistusliku kahjuhüvitise (punitive damages) mõistest, päritolust ja rollist. Tõrjuvast kahjuhüvitisest Saksa ja Eesti õiguses. Eesti isikuõiguste kaitsest

  19. Kujunemine omatehtud alkoholi valmistajaks ja levitajaks ning õigustused nendele tegevustele = Becoming a maker and distributor of homebrew alcohol and justifications for such activities : III koht bakalaureusetööde kategoorias / Cristo Pajust

    Index Scriptorium Estoniae

    Pajust, Cristo

    2009-01-01

    Bakalaureusetöös selgitati, kuidas kujunetakse omatehtud alkoholi valmistajaks ja levitajaks ning millised on seda ühiskonnas illegaalsena määratletud tegevust neutraliseerivad argumendid tegevuse õigustamisel enesele ja teistele. Töö lähtus sotsiaalse õppimise teooriast ja neutraliseerimisteooriast

  20. Giver specifik fodtræning og indlæg en yderligere effekt sammenlignet med et standard knæfokuseret træningsforløb for patienter med patellofemoral smertesyndrom?

    DEFF Research Database (Denmark)

    Mølgaard, Carsten; Andreasen, Jane; Christensen, Marianne

    tilstrækkelig evidens for en overbevisende effekt af fod- og knæortoser i behandlingen af PFPS patienter. Formål: At undersøge om en kombination af specifik fodtræning og indlæg kan forbedre effekten af et standard træningsregime i behandlingen af patellofemorale smerte syndrom (PFPS). Materiale og metode...

  1. Identification of metabolites in human and rat urine after oral administration of Xiao-Qing-Long-Tang granule using ultra high performance liquid chromatography combined with quadrupole time-of-flight mass spectrometry.

    Science.gov (United States)

    Zhou, Lei; Zhang, Qiang; Qi, Wen; Yan, Shuai; Qu, Jialin; Makino, Toshiaki; Yuan, Dan

    2017-09-01

    Xiao-Qing-Long-Tang is a traditional Chinese formula used for the treatment of cold syndrome, bronchitis, and nasal allergies for thousands of years. However, the in vivo integrated metabolism of its multiple components and the active chemical constituents of Xiao-Qing-Long-Tang remain unknown. In this study, a method using ultra high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry was established for the detection and identification of the metabolites in human and rat urine after oral administration of Xiao-Qing-Long-Tang. A total of 19 compounds were detected or tentatively identified in human urine samples, including eight prototypes and 11 metabolites. Also, a total of 50 compounds were detected or tentatively identified in rat urine samples, including 15 prototypes and 35 metabolites detected with either a highly sensitive extracted ion chromatogram method or the MS E determination using Mass Fragment software. Our results indicated that phase Ⅱ reactions (e.g. glucuronidation and sulfation) were the main metabolic pathways of flavones, while phase I reactions (e.g. demethylation and hydroxylation) were the major metabolic reaction for alkaloids, lignans, and ginger essential oil. This investigation provided important structural information on the metabolism of Xiao-Qing-Long-Tang and provided evidence to obtain a more comprehensive metabolic profile. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Effect of Xiao Chaihu Tang combined with intravenous chemotherapy on tumor markers and immune function in patients with advanced breast cancer

    Directory of Open Access Journals (Sweden)

    Jian-Ping Zhong

    2017-05-01

    Full Text Available Objective: To study the effect of Xiao Chaihu Tang combined with intravenous chemotherapy on tumor markers and immune function in patients with advanced breast cancer. Methods: 76 patients with advanced breast cancer treated in our hospital between May 2012 and November 2015 were collected and divided into the combined treatment group (n=34 who accepted Xiao Chaihu Tang combined with intravenous chemotherapy and the control group (n=42 who accepted intravenous chemotherapy alone according to different treatment, and the treatment cycle was 3 months for both groups. Before treatment and 3 months after treatment, ELISA method was used to detect serum levels of broad-spectrum tumor markers and breast cancerspecific tumor markers; flow cytometer was used to detect cellular immune function index levels, and turbidimetric immunoassay was used to detect humoral immune function index levels in peripheral blood. Results: Before treatment, differences in serum tumor marker levels as well as cellular immunity and humoral immunity index levels in peripheral blood were not statistically significant between two groups of patients (P>0.05; after 3 months of treatment, broad-spectrum tumor markers carcinoembryonic antigen (CEA, carbohydrate antigen 153 (CA153 and carbohydrate antigen 125 (CA125 levels in serum of combined treatment group were lower than those of control group, and breast cancer-specific tumor markers insulin-like growth factor-1 (IGF-1, midkine (MK, soluble E-cadherin (sEC and thymidine kinase 1 (TK1 levels were lower than those of control group (P<0.05; CD3+ and CD4+ T lymphocyte levels as well as CD4+/CD8+ ratio in peripheral blood of combined treatment group were higher than those of control group while CD8+ T lymphocyte level was lower than that of control group, and immunoglobulin G (IgG, immunoglobulin A (IgA and immunoglobulin M (IgM levels in peripheral blood were higher than those of control group (P<0.05. Conclusions: Xiao Chaihu Tang

  3. Discovery of estrogen receptor α modulators from natural compounds in Si-Wu-Tang series decoctions using estrogen-responsive MCF-7 breast cancer cells.

    Science.gov (United States)

    Liu, Li; Ma, Hongyue; Tang, Yuping; Chen, Wenxing; Lu, Yin; Guo, Jianming; Duan, Jin-Ao

    2012-01-01

    The binding between the estrogen receptor α (ER-α) and a variety of compounds in traditional Chinese formulae, Si-Wu-Tang (SWT) series decoctions, was studied using a stably-transfected human breast cancer cell line (MVLN). In 38 compounds tested from SWT series decoctions, the estrogen-like activity of 22 compounds was above 60% in 20 μg mL(-1). Furthermore, theoretical affinity of these compounds was certificated using the functional virtual screen of ER-α modulators by FlexX-Pharm. The accuracy of functional virtual screening of ER-α modulators could reach to 77.27%. The results showed that some compounds, such as organic acids and flavones in SWT series decoctions could be used as selective estrogen receptor modulators (SERMs) and could be selected for further development as potential agents for estrogen related diseases. Copyright © 2011 Elsevier Ltd. All rights reserved.

  4. The construction of the spatio-temporal database of the ancient Silk Road within Xinjiang province during the Han and Tang dynasties

    International Nuclear Information System (INIS)

    Bi, Jiantao; Wang, Xingxing; Luo, Guilin; Zhu, Zuojia

    2014-01-01

    As the bridge over the Chinese and Western civilization, the ancient Silk Road has made a huge contribution to cultural, economic, political exchanges between China and western countries. In this paper, we treated the historical period of Western Han Dynasty, Eastern Han Dynasty and Tang Dynasty as the research time domain, and the Western Regions' countries that were existed along the Silk Road at the mean time as the research spatial domain. Then we imported these data into the SQL Server database we constructed, from which we could either query the attribute information such as population, military force, the era of the Central Plains empire, the significant events taking place in the country and some related attribute information of these events like the happened calendar year in addition to some related spatial information such as the present location, the coordinates of the capital and the territory by inputting the name of the Western countries. At the same time we could query the significant events, government institution in Central Plains and the existent Western countries at the mean time by inputting the calendar year. Based on the database, associated with GIS, RS, Flex, C# and other related information technology and network technology, we could not only browsing, searching and editing the information of the ancient Silk Road in Xinjiang Province during the Han and Tang Dynasties, but preliminary analysing as well. This is the combination of archaeology and modern information technology, and the database could also be a reference to further study, research and practice in the related fields in the future

  5. Chlorpromazine-induced perturbations of bile acids and free fatty acids in cholestatic liver injury prevented by the Chinese herbal compound Yin-Chen-Hao-Tang.

    Science.gov (United States)

    Yang, Qiaoling; Yang, Fan; Tang, Xiaowen; Ding, Lili; Xu, Ying; Xiong, Yinhua; Wang, Zhengtao; Yang, Li

    2015-04-16

    Yin-Chen-Hao-Tang (YCHT), a commonly used as a traditional chinese medicine for liver disease. Several studies indicated that YCHT may improving hepatic triglyceride metabolism and anti-apoptotic response as well as decreasing oxidative stress .However, little is known about the role of YCHT in chlorpromazine (CPZ) -induced chlolestatic liver injury. Therefore, we aimed to facilitate the understanding of the pathogenesis of cholestatic liver injury and evaluate the effect of Yin-Chen-Hao-Tang (YCHT) on chlorpromazine (CPZ)-induced cholestatic liver injury in rats based on the change of bile acids (BAs) and free fatty acids (FFAs) alone with the biochemical indicators and histological examination. We conducted an experiment on CPZ-induced cholestatic liver injury in Wistar rats with and without YCHT for nine consecutive days. Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin (ALB), total bilirubin (TBIL), total cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol (LDL-C) were measured to evaluate the protective effect of YCHT against chlorpromazine (CPZ)-induced cholestatic liver injury. Histopathology of the liver tissue showed that pathological injuries were relieved after YCHT pretreatment. In addition, ultra-performance lipid chromatography coupled with quadrupole mass spectrometry (UPLC-MS) and gas chromatography coupled with mass spectrometry (GC-MS) was applied to determine the content of bile acids, free fatty acids, respectively. Obtained data showed that YCHT attenuated the effect of CPZ-induced cholestatic liver injury, which was manifested by the serum biochemical parameters and histopathology of the liver tissue. YCHT regulated the lipid levels as indicated by the reversed serum levels of TC, TG, and LDL-C. YCHT also regulated the disorder of BA and FFA metabolism by CPZ induction. Results indicated that YCHT exerted a protective effect on CPZ-induced cholestasis liver injury. The variance of

  6. Pharmacokinetic determination of ephedrine in Herba Ephedrae and Wu Tou Tang decoctions in rats using ultra performance liquid chromatography tandem mass spectrometry.

    Science.gov (United States)

    Zheng, Zhijie; Yan, Tongmeng; Chen, Weiying; Ye, Ling; Tang, Lan; Liu, Zhongqiu

    2012-08-01

    A rapid and sensitive ultra performance liquid chromatography tandem mass spectrometry method was developed and validated for the determination and quantification of ephedrine in rat plasma samples. An Acquity UPLC BEH C18 column (1.7 μm, 2.1 mm × 50 mm) was used for chromatographic separation. Electrospray ionization in the positive mode was used, and the precursor-fragment ion pairs of m/z 166/148 and m/z 289/97 were adopted to characterize ephedrine and testosterone (internal standard), respectively. The method was validated using 10, 100 and 500 ng/mL of ephedrine. It demonstrated adequate levels of precision and accuracy, matrix effect, extraction recovery and stability. Linearity over the concentration range of 0.5-2000 ng/mL was acceptable with a correlation coefficient (r²) better than 0.990. To determine the pharmacokinetic behaviour of this sympathomimetic compound in the Sprague-Dawley rats, ephedrine hydrochloride, Herba Ephedrae single-herb and Wu Tou Tang decoctions were administered orally, and ephedrine hydrochloride was also administered by intravenous injection, and blood samples were collected over 24 h. Ephedrine was measured in plasma and pharmacokinetic parameters were determined by using the standard non-compartmental method and calculated by using Practical Pharmacokinetic Program-Version 87/97. The AUC(0-t) and T(max) values were significantly different (p Tang decoction compared to the other oral treatments, suggesting that some components in the decoction may reduce the bioavailability of ephedrine.

  7. The construction of the spatio-temporal database of the ancient Silk Road within Xinjiang province during the Han and Tang dynasties

    Science.gov (United States)

    Bi, Jiantao; Luo, Guilin; Wang, Xingxing; Zhu, Zuojia

    2014-03-01

    As the bridge over the Chinese and Western civilization, the ancient Silk Road has made a huge contribution to cultural, economic, political exchanges between China and western countries. In this paper, we treated the historical period of Western Han Dynasty, Eastern Han Dynasty and Tang Dynasty as the research time domain, and the Western Regions' countries that were existed along the Silk Road at the mean time as the research spatial domain. Then we imported these data into the SQL Server database we constructed, from which we could either query the attribute information such as population, military force, the era of the Central Plains empire, the significant events taking place in the country and some related attribute information of these events like the happened calendar year in addition to some related spatial information such as the present location, the coordinates of the capital and the territory by inputting the name of the Western countries. At the same time we could query the significant events, government institution in Central Plains and the existent Western countries at the mean time by inputting the calendar year. Based on the database, associated with GIS, RS, Flex, C# and other related information technology and network technology, we could not only browsing, searching and editing the information of the ancient Silk Road in Xinjiang Province during the Han and Tang Dynasties, but preliminary analysing as well. This is the combination of archaeology and modern information technology, and the database could also be a reference to further study, research and practice in the related fields in the future.

  8. Patterns of HIV prevalence among injecting drug users in the cross-border area of Lang Son Province, Vietnam, and Ning Ming County, Guangxi Province, China

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    Hoang Tran V

    2005-08-01

    Full Text Available Abstract Background To assess patterns of injecting drug use and HIV prevalence among injecting drug users (IDUs in an international border area along a major heroin trans-shipment route. Methods Cross-sectional surveys of IDUs in 5 sites in Lang Son Province, Vietnam (n = 348 and 3 sites in Ning Ming County, Guangxi Province, China (n = 308. Respondents were recruited through peer referral ("snowball" methods in both countries, and also from officially recorded lists of IDUs in Vietnam. A risk behavior questionnaire was administered and HIV counseling and testing conducted. Results Participants in both countries were largely male, in their 20s, and unmarried. A majority of subjects in both countries were members of ethnic minority groups. There were strong geographic gradients for length of drug injecting and for HIV seroprevalence. Both mean years injecting and HIV seroprevalence declined from the Vietnamese site farthest from the border to the Chinese site farthest from the border. 10.6% of participants in China and 24.5% of participants in Vietnam reported crossing the international border in the 6 months prior to interview. Crossing the border by IDUs was associated with (1 distance from the border, (2 being a member of an ethnic minority group, and (3 being HIV seropositive among Chinese participants. Conclusion Reducing the international spread of HIV among IDUs will require programs at the global, regional, national, and "local cross border" levels. At the local cross border level, the programs should be coordinated on both sides of the border and on a sufficient scale that IDUs will be able to readily obtain clean injection equipment on the other side of the border as well as in their country of residence.

  9. IND UCTION OF SPAW NING IN THE TR OPICAL WALKING CATFISH (C la rias b atr ac hus BY CONTROLLI NG WATER L EVEL AND T EMPERAT URE

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    M. ZAIRIN JR.

    2001-01-01

    Full Text Available This experiment was carried out t o confirm the rol e of water level and w ater temperature i n indu cing t he s pawning o f tr opical walking catfi sh . Ma ture mal es an d females reared un de r 23 - 2 5 °C, were paired and in duced to spa wn by cont rolling w ater level and w ater temperature. Decr easi ng water level and returni ng it to its original level r esulted i n a low spawni ng r ate (l es s t han 6. 7 % at 23 °C . Decreasing water level with simultaneous increase in water temperature, followed by returning the respective levels to their originals gave high spa wning rates ( 41.7 — 50 %; whereas the s ame treatment but without a ny water temperature decrea sed when t he wate r le vel was return ed t o t he initial level, gave a lo w spawning rate (16 .7 %. In creasin g water level only, fail ed to ind uce spa wning . A high spawning rate was obtained also when changes in water level were ca rried out under high t emperature of 28 °C. No fish spawned in the ab sence of the environmental stimulation. From the results, i t is confirmed that water le vel and t emperature play important r oles i n i nducin g spaw ning of tropical walki ng catfish. Changes i n water t emperature probably increas e the sensitivity of fish to th e change in water level. Prolo nged exposure to high water tem perature c ould also improve the sensitivity of fish.

  10. Bu-Shen-Ning-Xin Decoction ameliorated the osteoporotic phenotype of ovariectomized mice without affecting the serum estrogen concentration or uterus

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    Wang L

    2015-08-01

    Full Text Available Ling Wang,1,2,* Xue-Min Qiu,1,2,* Yu-Yan Gui,1,2 Ying-Ping Xu,1,2 Hans-Jürgen Gober,3 Da-Jin Li1 1Laboratory for Reproductive Immunology, Hospital and Institute of Obstetrics and Gynecology, IBS, Fudan University Shanghai Medical College, 2Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, People’s Republic of China; 3Department of Pharmacy, Wagner Jauregg Hospital and Children’s Hospital, Linz, Austria *These authors contributed equally to this work Introduction: Bu-Shen-Ning-Xin Decoction (BSNXD, a traditional Chinese medicinal composition, has been used as a remedy for postmenopausal osteoporosis, but its effects on bone metabolism and the uterus have not been reported.Purpose: We aimed to determine the respective effects of BSNXD on the bones and the uterus of ovariectomized (OVX mice to evaluate the efficacy and safety of this herbal formula.Materials and methods: Postmenopausal osteoporosis animal models that were generated by ovariectomy were treated with BSNXD. Dual-energy X-ray absorptiometry was performed to analyze the bone mineral density, and histomorphometric analysis was performed to measure the parameters related to bone metabolism. Calcein labeling was performed to detect bone formation. The uteruses from the mice were weighed, and the histomorphometry was analyzed. Drug-derived serum was prepared to assess the 17-β-estradiol concentration via enzyme immunoassay.Results: BSNXD administration ameliorated the osteoporotic phenotype of OVX mice, as evidenced by an increase in the bone mineral density and bone volume; these effects could not be abolished by the administration of the aromatase inhibitor letrozole. Moreover, BSNXD had no effect on the serum estrogen concentration or uterus.Conclusion: These results suggest that BSNXD has ameliorating effects on bone loss due to estrogen deprivation without affecting the peripheral blood estrogen concentration or the uterus in OVX mice. Keywords

  11. Karistusõiguslik hädakaitse ja hädaseisund põhiõiguste piiramise alusena koolides ning nende suhestumine 1. jaanuaril 2016 jõustuva lastekaitseseaduse § 24 lõikega 3 / Anneli Soo

    Index Scriptorium Estoniae

    Soo, Anneli, 1984-

    2015-01-01

    Analüüs 1. jaanuaril 2016 jõustuva LaKS § 24 lõike 3 tähendusest teo õigusvastasust välistava asjaoluna ning kas see harmoneerub karistusõiguse dogmaatikaga hädakaitse ja hädaseisundi valdkonnas. Füüsilise vägivalla kasutamisest hädakaitse ja hädaseisundi olukorras koolis, vastavast kohtupraktikast

  12. Treatment of Goiter with Traditional Chinese Medicine Regimen Xing Qi Hua Ying Tang: A Clinical Study on 72 Patients with Multinodular and Diffuse Goiter.

    Science.gov (United States)

    Yang, Ming-Li; Lu, Bo

    2018-04-01

    The present work aimed to further explore the therapeutic potential of Xing Qi Hua Ying Tang (XQHYT) by conducting a systemic clinical study in patients with goiter. Seventy-two patients with either multinodular or diffuse goiter were enrolled and randomly assigned into treatment group receiving XQHYT (n = 36) and control group receiving Hai Zao Yu Hu Tang (n = 36). Traditional Chinese Medicine Hospital of Shanxi. Patients were diagnosed multinodular goiter or diffuse goiter resulting from Qi stagnation. All patients took the extract twice a day (100 mL each time) for two courses of treatment, of which a single course lasted for 3 months. Before the treatment was commenced and after the completion of the treatment, general body checks, thyroid function test, and goiter size examination were performed. Scoring of the clinical symptoms using Chinese medicine symptomatology was also done. The symptom score of the treatment group was significantly lower than that of the control group (treatment group, 8.26 ± 2.62; control group, 10.02 ± 2.62; p < 0.05). Substantial reduction in goiter size was seen in 82.3% of XQHYT-treated patients, whereas in the control group only 67.7% of patients exhibited constricted goiter. When assessed by both the Chinese medicine criteria and goiter size, the overall effective rate of the treatment group was 91.2%, whereas that of the control group was only 67.7%. The difference was statistically significant (p < 0.05). XQHYT did not affect the normal functions of liver, kidney, and heart. For both groups of patients, their levels of thyroid-stimulating hormone, free T4 and free T3 were normal before the treatment, and were not affected by the treatment. XQHYT was shown to be a promising therapeutic regimen for the treatment of goiter. The herbal regimen ameliorated clinical symptoms of patients that were accompanied with reduction in the size of goiter.

  13. Investigation on the upper Paleozoic Strata in Tang-e-Zakeen, and introducing Zakeen formation, Kuh-e Faraghan Zagros Basin, South Iran

    International Nuclear Information System (INIS)

    Ghavidel-Syooki, M.

    1998-01-01

    A thick clastic sequence is well-developed in Tang-e-Zakeen, Kuh-e-Faraghan, being situated approximately 80 Km north of Bandar Abbas. The sequence is 340 m. thick and mainly consists of sandstone, siltstone, shale and subordinate dolomitic beds. So far, this clastic sequence has been called Faraghan Formation. This rock unit lacks marine fauna and based on stratigraphic position, it was assigned to the Early Permian (Szabo and Kheradpir, 1978). Since then, a detailed palynological study has been carried out on the Faraghan Formation by the author. These studies resulted identification of numerous palynomorph taxa, including miospore and acritarch species. The known palynomorph taxa indicated that, a major part of Faraghan Formation belongs to the Devonian Period, while the rest is Early Permian. As a result, the National Iranian Stratigraphic Committee decided and agreed upon to divide the Faraghan Formation into two rock units, namely, the Zakeen Formation, embracing the Devonian strata, and Faraghan Formation for the Early Permian sequence in the Zagros Basin respectively. The Zakeen Formation derives from the Zakeen Village which is located in the southern flank of Kuh-e-Faraghan, about 80 km north of Bandar Abbas. The type section of Zakeen Formation attains a thickness of 285m. in Tang-e-Zakeen, Kuh-e-Faraghan, approximately 23 Km from the Zakeen village. It disconformably rests on the Sarchahan Formation, while it too, disconformably overlain by the Faraghan Formation. A total of 100 samples from the Zakeen Formation were selected and treated in the palynological laboratory of the Exploration Division of National Iranian Oil Company. 63 palynomorph taxa were encountered from the Zakeen Formation. The known species were arranged in five local stratigraphic assemblage zones. Zones I and II occur in a thickness of 96 m. of the Zakeen Formation, in ascending order, suggesting the Early Devonian whereas Zones III and IV occur Within 156 m. interval of the Zakeen

  14. Decreased absorption of midazolam in the stomach due to low pH induced by co-administration of Banha-sasim-tang

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    Jun Hyeon Jo

    2016-08-01

    Full Text Available Objectives Banha-sasim-tang (BST, which consists of seven different herbs, is one of the most popular herbal formulae for treating gastrointestinal disorders in Eastern Asia. The commonly used herbal medicine is often co-administered with other therapeutic drugs, which raises the possibility of herb–drug interactions and may modify the clinical safety profile of therapeutic drugs. Methods We investigated the potential herb–drug interactions between BST extract and midazolam (MDZ in mice. The area under the plasma concentration-time curve (AUC of MDZ and 1ʹ-hydroxymidazolam (1ʹ-OH-MDZ was evaluated for both oral and intraperitoneal administration of MDZ, following oral administration of BST (0.5 and 1 g/kg. Results It was found that the AUC of MDZ and 1ʹ-OH-MDZ was lower in case of oral administration of MDZ. Administration of BST extract was not associated with hepatic cytochrome P450 activity. BST extract induced a strong reduction in pH and it has been reported that oral mucosal absorption of MDZ is lower at low pH. The decreased absorption rate of MDZ might be caused by the ingredients of BST and may not be related to other factors such as increased excretion of MDZ by P-glycoprotein. Conclusions The altered pharmacokinetics of midazolam caused by co-administration with BST in vivo could be attributed to a decrease in pH and subsequent reduction of MDZ absorption rate.

  15. Ferulic Acid Orchestrates Anti-Oxidative Properties of Danggui Buxue Tang, an Ancient Herbal Decoction: Elucidation by Chemical Knock-Out Approach.

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    Amy G W Gong

    Full Text Available Ferulic acid, a phenolic acid derived mainly from a Chinese herb Angelica Sinensis Radix (ASR, was reported to reduce the formation of free radicals. Danggui Buxue Tang (DBT, a herbal decoction composing of Astragali Radix (AR and ASR, has been utilized for more than 800 years in China having known anti-oxidative property. Ferulic acid is a major active ingredient in DBT; however, the role of ferulic acid within the herbal mixture has not been resolved. In order to elucidate the function of ferulic acid within this herbal decoction, a ferulic acid-depleted herbal decoction was created and named as DBTΔfa. The anti-oxidative properties of chemically modified DBT decoction were systemically compared in cultured H9C2 rat cardiomyoblast cell line. The application of DBT and DBTΔfa into the cultures showed functions in (i decreasing the reactive oxygen species (ROS formation, detected by laser confocal; (ii increasing of the activation of Akt; (iii increasing the transcriptional activity of anti-oxidant response element (ARE; and (iv increasing the expressions of anti-oxidant enzymes, i.e. NQO1 and GCLM. In all scenario, the aforementioned anti-oxidative properties of DBTΔfa in H9C2 cells were significantly reduced, as compared to authentic DBT. Thus, ferulic acid could be an indispensable chemical in DBT to orchestrate multi-components of DBT as to achieve maximal anti-oxidative functions.

  16. The relationship between climate change and wars waged between nomadic and farming groups from the Western Han Dynasty to the Tang Dynasty period

    Science.gov (United States)

    Su, Y.; Liu, L.; Fang, X. Q.; Ma, Y. N.

    2016-01-01

    In ancient China, shifts in regional productivity of agriculture and animal husbandry, caused by climate change, either led to wars or peaceful relations between nomadic and farming groups. During the period spanning the Western Han Dynasty to the Tang Dynasty, 367 wars were waged between these groups. While 69 % of the wars were initiated by nomads, 62.4 % were won by the farming groups. On a centennial timescale, the battlegrounds were mostly in northern areas (at an average latitude of 38.92° N) during warm periods, moving southward (at an average latitude of 34.66° N) during cold periods. On a decadal timescale, warm climates corresponded to a high incidence of wars (a correlation coefficient of 0.293). While farming groups were inclined to initiate wars during dry and cold periods, their chances of achieving victory were reduced at such times. The main reasons for this are, first, that a warm climate provided a solid material foundation for nomadic and farming groups, contributing especially to enhanced productivity among the former. However, the overriding desire of nomadic groups to expand essential subsistence means led to wars. Second, during cold periods, farming groups moved to and settled in the south, while nomadic groups occupied the Central Plain. Thus, the locations of the battlefields also changed. While other factors also influenced these wars, climate change served as a backdrop, playing an indirect role in wars between these groups.

  17. Relationship between climate change and wars between nomadic and farming groups from the Western Han Dynasty to the Tang Dynasty period

    Science.gov (United States)

    Su, Y.; Liu, L.; Fang, X. Q.; Ma, Y. N.

    2015-07-01

    In ancient China, the change in regional agriculture and animal husbandry productivity caused by climate change led to either wars or peaceful relations between nomadic and farming groups. From the Western Han Dynasty to the Tang Dynasty there were 367 wars between the two groups. The nomadic people initiated 69 % of the wars, but 62.4 % were won by the farmers. On a 30 year-period timescale, warm climates corresponded to a high incidence of wars. The conflicts between the nomadic and farming groups took place in some areas which are sensitive to climate change. During the cold periods, the battlefields were mostly in the southern regions. The main causes which leading to the above results are following: (1) warm climate provided a solid material foundation for nomadic and farming groups, especially contributed to improve the productivity of nomadic group; meanwhile, the excessive desire for essential means of subsistence in nomadic group could led to wars. (2) During the cold periods, people of farming group moved to the south and construct the south, meanwhile, nomadic group occupied the central plains, thus the battlefields also changed. As the background, climate change plays an indirect role in wars between groups.

  18. Chinese Herbal Formula, Modified Danggui Buxue Tang, Attenuates Apoptosis of Hematopoietic Stem Cells in Immune-Mediated Aplastic Anemia Mouse Model

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    Jingwei Zhou

    2017-01-01

    Full Text Available A derivative formula, DGBX, which is composed of three herbs (Radix astragali, Radix Angelicae sinensis, and Coptis chinensis Franch, is derived from a famous Chinese herbal formula, Danggui Buxue Tang (DBT (Radix astragali and Radix Angelicae sinensis. We aimed to investigate the effects of DGBX on the regulation of the balance between proliferation and apoptosis of hematopoietic stem cells (HSCs due to the aberrant immune response in a mouse model of aplastic anemia (AA. Cyclosporine (CsA, an immunosuppressor, was used as the positive control. Our results indicated that DGBX could downregulate the production of IFNγ in bone marrow cells by interfering with the binding between SLAM and SAP and the expressions of Fyn and T-bet. This herbal formula can also inhibit the activation of Fas-mediated apoptosis, interferon regulatory factor-1-induced JAK/Stat, and eukaryotic initiation factor 2 signaling pathways and thereby induce proliferation and attenuate apoptosis of HSCs. In conclusion, DGBX can relieve the immune-mediated destruction of HSCs, repair hematopoietic failure, and recover the hematopoietic function of HSCs in hematogenesis. Therefore, DGBX can be used in traditional medicine against AA as a complementary and alternative immunosuppressive therapeutic formula.

  19. Antidiabetic Effect of Tibetan Medicine Tang-Kang-Fu-San on High-Fat Diet and Streptozotocin-Induced Type 2 Diabetic Rats

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    Bailu Duan

    2017-01-01

    Full Text Available The aim of this study was to investigate the antidiabetic effects of a Tibetan medicine, Tang-Kang-Fu-San (TKFS, on experimental type 2 diabetes mellitus (T2DM rats and to explore its underlying mechanisms. Firstly two major chemical compositions of TKFS, gallic acid and curcumin, were characterized by HPLC fingerprint analysis. Next T2DM in rats was induced by high-fat diet and a low-dose streptozotocin (STZ 35 mg/kg. Then oral gavage administration of three different doses of TKFS (0.3 g/kg, 0.6 g/kg, and 1.2 g/kg was given to T2DM rats. Experimental results showed that TKFS dramatically reduced the levels of fasting blood glucose, fasting blood insulin, triglyceride, total cholesterol, LDL cholesterol, and HDL cholesterol, even though it did not alter the animal body weight. The downregulation of phosphorylation-AKT (p-AKT and glucose transporter-4 (GLUT4 in skeletal muscle of T2DM rats was restored and abnormal pathological changes in pancreas tissues were also improved. Our work showed that TKFS could alleviate diabetic syndromes, maintain the glucose homeostasis, and protect against insulin resistance in T2DM rats, and the improvement of AKT phosphorylation and GLUT4 translocation in skeletal muscle would be one of its possible underlying mechanisms.

  20. A Chinese Herbal Decoction, Danggui Buxue Tang, Stimulates Proliferation, Differentiation and Gene Expression of Cultured Osteosarcoma Cells: Genomic Approach to Reveal Specific Gene Activation

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    Roy C. Y. Choi

    2011-01-01

    Full Text Available Danggui Buxue Tang (DBT, a Chinese herbal decoction used to treat ailments in women, contains Radix Astragali (Huangqi; RA and Radix Angelicae Sinensis (Danggui; RAS. When DBT was applied onto cultured MG-63 cells, an increase of cell proliferation and differentiation of MG-63 cell were revealed: both of these effects were significantly higher in DBT than RA or RAS extract. To search for the biological markers that are specifically regulated by DBT, DNA microarray was used to reveal the gene expression profiling of DBT in MG-63 cells as compared to that of RA- or RAS-treated cells. Amongst 883 DBT-regulated genes, 403 of them are specifically regulated by DBT treatment, including CCL-2, CCL-7, CCL-8, and galectin-9. The signaling cascade of this DBT-regulated gene expression was also elucidated in cultured MG-63 cells. The current results reveal the potential usage of this herbal decoction in treating osteoporosis and suggest the uniqueness of Chinese herbal decoction that requires a well-defined formulation. The DBT-regulated genes in the culture could serve as biological responsive markers for quality assurance of the herbal preparation.

  1. Serum metabonomics study of anti-depressive effect of Xiao-Chai-Hu-Tang on rat model of chronic unpredictable mild stress.

    Science.gov (United States)

    Xiong, Zhili; Yang, Jie; Huang, Yue; Zhang, Kuo; Bo, Yunhai; Lu, Xiumei; Su, Guangyue; Ma, Jie; Yang, Jingyu; Zhao, Longshan; Wu, Chunfu

    2016-09-01

    Xiao-Chai-Hu-Tang (XCHT) has been proven to be effective for the clinical treatment of depression. However, the mechanisms of definite antidepressant-like effects and detailed metabolic biomarkers were still unclear in this prior study. Here, we have investigated the metabolic profiles and potential biomarkers in a chronic unpredictable mild stress model after treatment with XCHT. Metabonomics based on ultra-high performance liquid chromatography coupled with mass spectrometry was used to profile the metabolic fingerprints of serum obtained from a rat model with chronic unpredictable mild stress with and without XCHT treatment. The model rats showed a significant decrease in sucrose preference and food consumption, and these depression-like symptoms were significantly improved by XCHT. Through principal component analysis (PCA), nine potential biomarkers of tryptophan, uric acid, phenylalanine, cholic acid and lysophosphatidylcholine (C18:0 LPC, C16:0 LPC, C16:1 LPC, C18:1 LPC, C20:4 LPC) were characterized as potential biomarkers involved the pathogenesis of depression. The therapeutic effect of XCHT on depression may involve in amino acid metabolism, lipid metabolism, oxidative stress and inflammation response. The present investigation highlights that metabonomics is a valuable tool for studying the essence of depression as well as evaluating the efficacy of the corresponding drug treatment. Copyright © 2016 Elsevier B.V. All rights reserved.

  2. A Systems Biology-Based Investigation into the Pharmacological Mechanisms of Sheng-ma-bie-jia-tang Acting on Systemic Lupus Erythematosus by Multi-Level Data Integration.

    Science.gov (United States)

    Huang, Lin; Lv, Qi; Liu, Fenfen; Shi, Tieliu; Wen, Chengping

    2015-11-12

    Sheng-ma-bie-jia-tang (SMBJT) is a Traditional Chinese Medicine (TCM) formula that is widely used for the treatment of Systemic Lupus Erythematosus (SLE) in China. However, molecular mechanism behind this formula remains unknown. Here, we systematically analyzed targets of the ingredients in SMBJT to evaluate its potential molecular mechanism. First, we collected 1,267 targets from our previously published database, the Traditional Chinese Medicine Integrated Database (TCMID). Next, we conducted gene ontology and pathway enrichment analyses for these targets and determined that they were enriched in metabolism (amino acids, fatty acids, etc.) and signaling pathways (chemokines, Toll-like receptors, adipocytokines, etc.). 96 targets, which are known SLE disease proteins, were identified as essential targets and the rest 1,171 targets were defined as common targets of this formula. The essential targets directly interacted with SLE disease proteins. Besides, some common targets also had essential connections to both key targets and SLE disease proteins in enriched signaling pathway, e.g. toll-like receptor signaling pathway. We also found distinct function of essential and common targets in immune system processes. This multi-level approach to deciphering the underlying mechanism of SMBJT treatment of SLE details a new perspective that will further our understanding of TCM formulas.

  3. Production extensive de jeunes saumons atlantiques (Salmo salar L. d'un an dans l'étang du Boucheron (Corrèze

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    DUMAS J.

    1981-07-01

    Full Text Available Dans le cadre du plan de restauration du Saumon dans la Dordogne, un élevage extensif de tacons de repeuplement est expérimenté dans un étang de pénéplaine où des alevins de saumons ont été immergés. Pour une première année d'élevage, cette pièce d'eau a procuré 2 150 jeunes saumons d'un an d'une grande taille moyenne (13,1 cm pour 21,2 g. La proportion de saumoneaux (smolts y est très importante (80,3 %. La survie depuis la mise en charge est élevée (14,3 % comparée à celle observée dans les rivières à saumons. La densité du peuplement à la récolte est, par hectare, de 879 juvéniles pour un poids de 18,6 kg. Les nombreux plans d'eau sur le haut bassin de la Dordogne peuvent constituer à peu de frais un outil de production de jeunes saumons pour le repeuplement de cette rivière.

  4. Si-Wu-tang extract stimulates bone formation through PI3K/Akt/NF-κB signaling pathways in osteoblasts.

    Science.gov (United States)

    Wu, Chi-Ming; Chen, Po-Chun; Li, Te-Mao; Fong, Yi-Chin; Tang, Chih-Hsin

    2013-10-24

    Si-Wu-Tang (SWT), a Traditional Chinese Medicine (TCM) formula, is widely used for the treatment of gynopathies diseases such as menstrual discomfort, climacteric syndrome, dysmenorrhea, and other estrogen-related diseases. Recent studies have shown that SWT can treat primary dysmenorrhea, have anti-pruritic anti-inflammatory effects, and protect against radiation-induced bone marrow damage in an animal model. It has been reported that anti-inflammatory and anti-oxidant agents have the potential to treat osteoporosis by increasing bone formation and/or suppressing bone resorption. However, the effect of SWT on bone cell function has not yet been reported. Alkaline phosphatase (ALP), bone morphogenetic proteins (BMP)-2, and osteopontin (OPN) mRNA expression was analyzed by qPCR. The mechanism of action of SWT extract was investigated using western blotting. The in vivo anti-osteoporotic effect of SWT extract was assessed in ovariectomized mice. Here, we report that SWT increases ALP, BMP-2, and OPN expression as well as bone mineralization. In addition, we show that the PI3K, Akt, and NF-κB signaling pathways may be involved in the SWT-mediated increase in gene expression and bone mineralization. Notably, treatment of mice with SWT extract prevented bone loss induced by ovariectomy in vivo. SWT may be used to stimulate bone formation for the treatment of osteoporosis.

  5. Review of Cycadophila Xu, Tang & Skelley (Coleoptera: Erotylidae: Pharaxonothinae) inhabiting Cycas (Cycadaceae) in Asia, with descriptions of a new subgenus and thirteen new species.

    Science.gov (United States)

    Skelley, Paul; Xu, Guang; Tang, William; Lindström, Anders J; Marler, Thomas; Khuraijam, Jibankumar Singh; Singh, Rita; Radha, P; Rich, Stephen

    2017-05-12

    The genus Cycadophila Xu, Tang & Skelley (Coleoptera: Erotylidae: Pharaxonothinae) associated with Cycas L. (Cycadacaeae) in Asia is reviewed. Strobilophila, new subgenus, with five species is described: Cycadophila (Strobilophila) assamensis new species, C. (S.) hiepi new species, C. (S.) kwaiensis new species, C. (S.) tansachai new species and C. (S.) yangi new species, all associated with Cycas. For the nominate subgenus Cycadophila eight new species are described, Cycadophila (Cycadophila) abyssa new species, C. (C.) collina new species,C. (C.) samara new species, C. (C.) convexa new species, C. (C.) cyclochasma new species, C. (C.) eurynota new species, C. (C.) papua new species, and C. (C.) torquata new species and four new generic combinations are proposed: C. (C.) vittata (Arrow) new combination, C. (C.) discimaculata (Mader) new combination, C. (C.) intermedia (Chûjô) new combination, and C. (C.) lata (Grouvelle) new combination. Only the first three listed species of the nominate subgenus have known associations with Cycas. Species are distinguished on the basis of morphology and/or by analysis of 16S rRNA gene sequences. The larva of subgenus Strobilophila is described based on individuals collected together with adults and matched with analysis of 16S rRNA gene sequences. Keys to subgenera and species of known adults and larvae are provided.

  6. Immunomodulatory effects of Longdan Xiegan Tang on CD4+/CD8+ T cells and associated inflammatory cytokines in rats with experimental autoimmune uveitis.

    Science.gov (United States)

    Tang, Kai; Guo, Dadong; Zhang, Lian; Guo, Junguo; Zheng, Fengming; Si, Junkang; Bi, Hongsheng

    2016-09-01

    Longdan Xiegan Tang (LXT) is a mixture of herbal extracts commonly used in traditional Chinese medicine that may exert immunomodulatory effects for the treatment of autoimmune diseases. However, the detailed mechanisms that mediate the actions of LXT are unclear. The present study induced an experimental autoimmune uveitis (EAU) model in Lewis rats via injection of IRBP1177‑1191 emulsion. The model was used to investigate the effects of LXT on EAU rats and assess the efficacy of LXT by measuring clinical manifestations and histopathological changes caused by EAU. Additionally, alterations in the ratio of CD4+/CD8+‑T cells were determined by flow cytometry, and the expression of interferon (IFN)‑γ, interleukin (IL)‑17, IL‑10 and tumor necrosis factor (TNF)‑α were measured using reverse transcription‑quantitative polymerase chain reaction and enzyme‑linked immunosorbent assay analysis. The results of the present study demonstrate that LXT can efficiently alleviate the symptoms of EAU, inhibit the differentiation of uveitogenic CD4+ T cells and reduce the expression of proinflammatory cytokines, including IFN‑γ, IL‑17 and TNF‑α. Furthermore, LXT promotes the production of IL‑10 and accelerates the recovery of EAU, indicating that the immunomodulatory effects of LXT may potentially be used for the treatment of uveitis.

  7. Simultaneous determination of five components in rat plasma by UPLC-MS/MS and its application to a comparative pharmacokinetic study in Baihe Zhimu Tang and Zhimu extract.

    Science.gov (United States)

    Li, Guolong; Tang, Zhishu; Yang, Jie; Duan, Jinao; Qian, Dawei; Guo, Jianming; Zhu, Zhenhua; Liu, Hongbo

    2015-04-15

    Baihe Zhimu Tang (BZT) is a famous traditional Chinese medicine recipe to treat dry coughing due to yin deficiency and for moisturizing the lungs. Zhimu is an essential ingredient in BZT used to treat inflammation, fever and diabetes. The most important active components in Zhimu are flavonoids such as neomangiferin, mangiferin, and steroid saponins (e.g., timosaponin BII, anemarsaponin BIII, timosaponin AIII). The aim of this study was to compare the pharmacokinetics of mangiferin, neomangiferin, timosaponin BII, anemarsaponin BIII and timosaponin AIII in rat plasma after oral administration of BZT and Zhimu extract (ZME). A sensitive, reliable and robust LC-MS/MS method to simultaneously determine steroid saponins and flavonoids in rat plasma was successfully validated. Significant differences (p < 0.05) were found in the pharmacokinetic parameters of timosaponin BII, anemarsaponin BIII and timosaponin AIII between BZT and ZME. It was surmised that formula compatibility could significantly influence the pharmacokinetics of BZT and our study is the first to study the administration of BZT based on pharmacokinetic studies.

  8. Spatial distribution and source apportionment of water pollution in different administrative zones of Wen-Rui-Tang (WRT) river watershed, China.

    Science.gov (United States)

    Yang, Liping; Mei, Kun; Liu, Xingmei; Wu, Laosheng; Zhang, Minghua; Xu, Jianming; Wang, Fan

    2013-08-01

    Water quality degradation in river systems has caused great concerns all over the world. Identifying the spatial distribution and sources of water pollutants is the very first step for efficient water quality management. A set of water samples collected bimonthly at 12 monitoring sites in 2009 and 2010 were analyzed to determine the spatial distribution of critical parameters and to apportion the sources of pollutants in Wen-Rui-Tang (WRT) river watershed, near the East China Sea. The 12 monitoring sites were divided into three administrative zones of urban, suburban, and rural zones considering differences in land use and population density. Multivariate statistical methods [one-way analysis of variance, principal component analysis (PCA), and absolute principal component score-multiple linear regression (APCS-MLR) methods] were used to investigate the spatial distribution of water quality and to apportion the pollution sources. Results showed that most water quality parameters had no significant difference between the urban and suburban zones, whereas these two zones showed worse water quality than the rural zone. Based on PCA and APCS-MLR analysis, urban domestic sewage and commercial/service pollution, suburban domestic sewage along with fluorine point source pollution, and agricultural nonpoint source pollution with rural domestic sewage pollution were identified to the main pollution sources in urban, suburban, and rural zones, respectively. Understanding the water pollution characteristics of different administrative zones could put insights into effective water management policy-making especially in the area across various administrative zones.

  9. Simultaneous Determination of Nine Active Compounds of the Traditional Chinese Medicinal Prescription Shaoyao-Gancao-Tang and Analysis of the Relationship between Therapeutical Effect and Compatibility of Medicines

    Science.gov (United States)

    Zhang, Guijun; Wang, Meng; Wang, Jingjuan; Zeng, Weixin; Gao, Xiaomei

    2014-01-01

    A simple and sensitive HPLC-DAD detection method was established for the simultaneous determination of nine compounds including oxypaeoniflorin, albiflorin, paeoniflorin, benzoylpaeoniflorin, glycyrrhizic acid, liquiritin, isoliquiritin, liquiritigenin, and isoliquiritigenin in the Traditional Chinese Medicinal Prescription Shaoyao-Gancao-Tang (SGT) and we analyze the relationship between therapeutical effect and compatibility of medicines by using an Agilent extend-C18 column at a flow rate of 1 mL/min. The column temperature was maintained at 30°C and the detection wavelength was set at 230 nm for oxypaeoniflorin, albiflorin, paeoniflorin, benzoylpaeoniflorin, and glycyrrhizic acid; 276 nm for liquiritin and liquiritigenin; 360 nm for isoliquiritin and isoliquiritigenin. The total contents of the nine compounds in SGT varied from 4.65 to 20.06 mg/mL. The results of this study showed that the content of chemical compounds of Traditional Chinese Medicinal Prescription is mainly influenced by the dosage and compatibility of medicines and the therapeutical effect of Traditional Chinese Medicinal prescription is mainly influenced by the dosage and compatibility of medicines. The method could be suitable for quality control of SGT with bioactive multicompounds. PMID:25431610

  10. Identification of Multiple Ingredients for a Traditional Chinese Medicine Preparation (Bu-yang-huan-wu-tang by Liquid Chromatography Coupled with Tandem Mass Spectrometry

    Directory of Open Access Journals (Sweden)

    Tung-Hu Tsai

    2013-09-01

    Full Text Available Bu-yang-huan-wu-tang (BYHWT is a popular Traditional Chinese Medicine formula consisting of seven herbal medicines (Astragalus membranaceus, Angelica sinensis, Paeonia lactiflora, Ligusticum chuanxiong, Carthamus tinctorius, Amygdalus persica and Pheretima aspergillum, that has been used in China for centuries to overcome stroke-induced disability. To ensure the consistency of quality, a reliable analytical method is required, therefore, we developed a liquid chromatography with tandem mass spectrometry (LC-MS/MS method for quantitative analysis of the major constituents in BYHWT. The herbal ingredients consisting of the cycloartane-type triterpene glycosides of astragaloside I, astragaloside II and astragaloside IV; isoflavones of formononetin, ononin calycosin, calycosin-7-O-β-d-glucoside; ligustilide and paeoniflorin were separated on a C18 column with gradient elution of methanol/10 mM ammonium acetate buffer–formic acid (100:0.1, v/v. This study was performed by a mass spectrometer using electrospray ionization (ESI with positive ionization ions monitored in the multiple reaction-monitoring (MRM mode. The linearity, accuracy, precision, limit of detection (LOD and lower limit of quantification (LLOQ were validated for this quantification method, and the sensitivity, reliability and reproducibility were all confirmed. The experiments provided a good method for analyzing BYHWT extracts. This study also quantitated the active components in various brands of commercially available products. The results indicated that the pharmaceutical industrial products of BYHWT exhibited considerable variation in their contents of the herbal compounds.

  11. Involvement of the Cerebral Monoamine Neurotransmitters System in Antidepressant-Like Effects of a Chinese Herbal Decoction, Baihe Dihuang Tang, in Mice Model

    Directory of Open Access Journals (Sweden)

    Meng-Li Chen

    2012-01-01

    Full Text Available Baihe Dihuang Tang (BDT is a renowned Chinese herbal formula which is commonly used for treating patients with mental instability, absentmindedness, insomnia, deficient dysphoria, and other psychological diseases. These major symptoms closely associated with the depressive disorders. BDT was widely popular use for treating emotion-thought disorders for many years in China. In the present study, the antidepressant-like effect of BDT in mice was investigated by using the forced swim test (FST and the tail suspension test (TST. The underlying mechanism was explored by determining the effect of BDT on the level of cerebral monoamine neurotransmitters. BDT (9 and 18 g/kg, p.o. for 14 days administration significantly reduced the immobility time in both the FST and the TST without changing locomotion in the open field-test (OFT. Moreover, BDT treatment at the dose of 18 g/kg inhibited reserpine-induced ptosis. Meanwhile, BDT enhanced 5-HT and NA levels in mouse cerebrum as well as decreased the ratio of 5-HT compared to its metabolite, 5-HIAA, (turnover, 5-HIAA/5-HT after TST. The results demonstrated that the antidepressant-like effect of BDT is mediated, at least partially, via the central monoaminergic neurotransmitter system.

  12. Daesiho-Tang Is an Effective Herbal Formulation in Attenuation of Obesity in Mice through Alteration of Gene Expression and Modulation of Intestinal Microbiota.

    Science.gov (United States)

    Hussain, Ahtesham; Yadav, Mukesh Kumar; Bose, Shambhunath; Wang, Jing-Hua; Lim, Dongwoo; Song, Yun-Kyung; Ko, Seong-Gyu; Kim, Hojun

    2016-01-01

    Obesity has become a major global health challenge due to its increasing prevalence, and the associated health risk. It is the main cause of various metabolic diseases including diabetes, hypertension, cardiovascular disease, stroke and certain forms of cancer. In the present study we evaluated the anti-obesity property of Daesiho-tang (DSHT), an herbal medicine, using high fat diet (HFD)-induced obese mice as a model. Our results showed that DSHT ameliorated body weight gain, decreased total body fat, regulated expression of leptin and adiponectin genes of adipose tissue and exerted an anti-diabetic effect by attenuating fasting glucose level and serum insulin level in HFD-fed animals. In addition, DSHT-treatment significantly reduced total cholesterol (TC), triglycerides (TG) and increased high density lipoprotein-cholesterol (HDL), glutamic pyruvic transaminase (GPT) and glutamic oxaloacetic transaminase (GOT) levels in serum and reduced deposition of fat droplets in liver. DSHT treatment resulted in significantly increased relative abundance of bacteria including Bacteroidetes, Bacteroidetes/Firmicutes ratio, Akkermansia Bifidobacterium., Lactobacillus, and decreased the level of Firmicutes. Using RT2 profiler PCR array, 39 (46%) genes were found to be differentially expressed in HFD-fed mice compared to normal control. However, normal gene expressions were restored in 36 (92%) genes of HFD-fed mice, when co-exposed to DSHT. The results of this study demonstrated that DSHT is an effective herbal formulation in attenuation of obesity in HFD-fed mice through alteration of gene expressions and modulation of intestinal microbiota.

  13. Risk analysis of heavy metal concentration in surface waters across the rural-urban interface of the Wen-Rui Tang River, China.

    Science.gov (United States)

    Qu, Liyin; Huang, Hong; Xia, Fang; Liu, Yuanyuan; Dahlgren, Randy A; Zhang, Minghua; Mei, Kun

    2018-06-01

    Heavy metal pollution is a major concern in China because of its serious effects on human health. To assess potential human health and ecological risks of heavy metal pollution, concentration data for seven heavy metals (As, Pb, Cd, Cr, Hg, Cu, Zn) from 14 sites spanning the rural-urban interface of the Wen-Rui Tang River watershed in southeast China were collected from 2000 to 2010. The heavy metal pollution index (HPI), hazard index (HI) and carcinogenic risk (CR) metrics were used to assess potential heavy metal risks. Further, we evaluated the uncertainty associated with the risk assessment indices using Monte Carlo analysis. Results indicated that all HPI values were lower than the critical level of 100 suggesting that heavy metal levels posed acceptable ecological risks; however, one site having an industrial point-source input reached levels of 80-97 on several occasions. Heavy metal concentrations fluctuated over time, and the decrease after 2007 is due to increased wastewater collection. The HI suggested low non-carcinogenic risk throughout the study period (HI  10 -4 ). While most metrics for human health risk did not exceed critical values for heavy metals, there is still a potential human health risk from chronic exposure to low heavy metal concentrations due to long-term exposure and potential metal interactions. Results of this study inform water pollution remediation and management efforts designed to protect public health in polluted urban area waterways common in rapidly developing regions. Copyright © 2018 Elsevier Ltd. All rights reserved.

  14. Simultaneous determination of thirteen flavonoids from Xiaobuxin-Tang extract using high-performance liquid chromatography coupled with electrospray ionization mass spectrometry.

    Science.gov (United States)

    Cen, Meifeng; Ruan, Jinxiu; Huang, Lihua; Zhang, Zhenqing; Yu, Nengjiang; Zhang, Youzhi; Cheng, Xuange; Xiong, Xiaohong; Wang, Guixiang; Zang, Linquan; Wang, Sujun

    2015-11-10

    A simple and reliable high performance liquid chromatography coupled with electrospray ionization mass spectrometry (HPLC-ESI-MS) analysis method was established to simultaneously determine thirteen flavonoids of Xiaobuxing-Tang in intestine perfusate, namely onpordin, 3'-O-methylorobol, glycitein, patuletin, genistein, luteolin, quercetin, nepitrin, quercimeritrin, daidzin, patulitrin, quercetagitrin and 3-glucosylisorhamnetin. Detection was performed on a quadrupole mass spectrometer equipped with an electrospray ionization (ESI) source operating in negative ionization mode. Negative ion ESI was used to form deprotonated molecules at m/z 315 for onpordin, m/z 299 for 3'-O-methylorobol, m/z 283 for glycitein, m/z 331 for patuletin, m/z 269 for genistein, m/z 285 for luteolin, m/z 301 for quercetin, m/z 477 for nepitrin, m/z 463 for quercimeritrin, m/z 461 for daidzin, m/z 493 for patulitrin, m/z 479 for quercetagitrin, m/z 477 for 3-glucosylisorhamnetin and m/z 609.2 for rutin. The linearity, sensitivity, selectivity, repeatability, accuracy, precision, recovery and matrix effect of the assay were evaluated. The proposed method was successfully applied to simultaneous determination of these thirteen flavonoids, and using this method, the intestinal absorption profiles of thirteen flavonoids were preliminarily predicted. Copyright © 2015 Elsevier B.V. All rights reserved.

  15. Simultaneous determination of bioactive constituents in Danggui Buxue Tang for quality control by HPLC coupled with a diode array detector, an evaporative light scattering detector and mass spectrometry.

    Science.gov (United States)

    Yi, Ling; Qi, Lian-Wen; Li, Ping; Ma, Yi-Han; Luo, Yong-Jing; Li, Hai-Yun

    2007-09-01

    Danggui Buxue Tang (DBT), a classical traditional Chinese formula comprising Radix Angelicae Sinensis (RAS) and Radix Astragali (RA), has been widely used to treat menopausal irregularity in Chinese women for nearly 800 years. In this study, a comprehensive analytical method of simultaneously determining the main types of bioactive constituents, eighteen in all from the formula, involving flavonoids, saponins, organic acid and some volatile compounds, was developed. This method was based on HPLC coupled to a diode array and evaporative light scattering detectors (HPLC-DAD-ELSD) on a common reverse-phase C(18) column. Liquid chromatography coupled with on-line electrospray ionization mass spectrometry (LC-ESI-MS) was also used to further validate and analyze the constituents. It was found that 0.3% aqueous formic acid and acetonitrile was the optimum mobile phase for gradient elution. This method, which showed good precision and accuracy, was successfully used to quantify the bioactive constituents in six products. As a result, the validated HPLC method, together with the LC-ESI-MS analysis, provided a new basis for assessing the quality of traditional Chinese medicinal compound preparations (TCMCPs) consisting of many bioactive components.

  16. Optimization of high pressure machine decocting process for Dachengqi Tang using HPLC fingerprints combined with the Box-Behnken experimental design.

    Science.gov (United States)

    Xie, Rui-Fang; Shi, Zhi-Na; Li, Zhi-Cheng; Chen, Pei-Pei; Li, Yi-Min; Zhou, Xin

    2015-04-01

    Using Dachengqi Tang (DCQT) as a model, high performance liquid chromatography (HPLC) fingerprints were applied to optimize machine extracting process with the Box-Behnken experimental design. HPLC fingerprints were carried out to investigate the chemical ingredients of DCQT; synthetic weighing method based on analytic hierarchy process (AHP) and criteria importance through intercriteria correlation (CRITIC) was performed to calculate synthetic scores of fingerprints; using the mark ingredients contents and synthetic scores as indicators, the Box-Behnken design was carried out to optimize the process parameters of machine decocting process under high pressure for DCQT. Results of optimal process showed that the herb materials were soaked for 45 min and extracted with 9 folds volume of water in the decocting machine under the temperature of 140 °C till the pressure arrived at 0.25 MPa; then hot decoction was excreted to soak Dahuang and Mangxiao for 5 min. Finally, obtained solutions were mixed, filtrated and packed. It concluded that HPLC fingerprints combined with the Box-Behnken experimental design could be used to optimize extracting process of traditional Chinese medicine (TCM).

  17. Rhein 8-O-β-D-Glucopyranoside Elicited the Purgative Action of Daiokanzoto (Da-Huang-Gan-Cao-Tang), Despite Dysbiosis by Ampicillin.

    Science.gov (United States)

    Takayama, Kento; Tabuchi, Norihiko; Fukunaga, Masahito; Okamura, Nobuyuki

    2016-01-01

    Sennoside A (SA), the main purgative constituent of Daiokanzoto (da-huang-gan-cao-tang; DKT), is generally regarded as a prodrug that is transformed into an active metabolite by β-glucosidase derived from Bifidobacterium spp. It has been suggested that antibiotics would promote dysbiosis, and thereby inhibit the purgative activity of DKT. In this study, ampicillin was administered to mice for 8 d, and the changes in the SA metabolism of SA alone and of DKT were investigated. The results showed that the SA metabolism of SA singly continued to be inhibited by ampicillin, but that of DKT was activated from day 3 under the same conditions. In order to investigate the mechanism of SA metabolism activated by DKT in the mice administered ampicillin, changes in the SA metabolism were observed in the presence of rhein 8-O-β-D-glucopyranoside (RG) in rhubarb and liquiritin in glycyrrhiza, both of which accelerated the SA metabolism. In fact, RG achieved an activation of SA metabolism similar to that by DKT. The purgative action of DKT, which was continued treatment of the ampicillin, was significantly greater than that by SA alone, and it was shown that RG was involved in this effect. We also analyzed changes in the intestinal microbiota before and after administration of ampicillin. No Bifidobacteria were detected throughout the treatment, but the population of Bacteroides was significantly increased after 3 d under the same conditions. Taken together, these results strongly suggested that the RG in DKT changed the function of Bacteroides and thereby allowed DKT to metabolize SA.

  18. Traditional Chinese medicine, Qing Ying Tang, ameliorates the severity of acute lung injury induced by severe acute pancreatitis in rats via the upregulation of aquaporin-1.

    Science.gov (United States)

    Gao, Zhenming; Xu, Junfeng; Sun, Deguang; Zhang, Rixin; Liang, Rui; Wang, Liming; Fan, Rong

    2014-12-01

    Aquaporin-1 (AQP-1) is expressed in lung endothelial cells and regulates water transport; thus, AQP-1 plays an important role in a number of edema-associated lung diseases. Qing Yin Tang (QYT), a traditional Chinese medicine, has been shown to effectively reduce the mortality rate of acute lung injury (ALI) induced by severe acute pancreatitis (SAP). The current study aimed to investigate the detailed mechanisms underlying the effects of QYT on ALI induced by SAP, particularly the effects on the expression levels of AQP-1 in the lung tissue. ALI was established in Wister rats who were subsequently divided into four groups: SHAM, ALI, dexamethasone (DEX) and QYT groups (n=8 per group). In the QYT group, 20 ml/kg QYT was administered by gavage immediately following the induction of SAP. Blood and lung tissues were collected 8 h following the induction of pancreatitis. The lung wet/dry ratio, as well as the levels of blood gases, serum amylase and tumor necrosis factor-α (TNF-α), were measured at 4, 8 and 12 h following SAP-associated ALI induction surgery. The expression levels of AQP-1 in the lung tissue were detected by quantitative polymerase chain reaction, immunohistochemistry and western blot analysis. No statistically significant differences were observed with regard to the levels of serum amylase, wet/dry ratio, partial pressure of oxygen, serum TNF-α and pathological changes in the pulmonary tissue between the QYT and DEX groups; however, a statistically significant difference was observed when compared with the ALI group. The expression levels of AQP-1 significantly increased (P<0.05) and lung edema was alleviated in the QYT and DEX groups, when compared with ALI group. Therefore, the expression level of AQP-1 is associated with pulmonary edema. QYT protects the lungs from injury induced by SAP via the upregulation of AQP-1, which suppresses TNF-α expression.

  19. Inhibitory effect of Daesungki-Tang on the invasiveness potential of hepatocellular carcinoma through inhibition of matrix metalloproteinase-2 and -9 activities

    International Nuclear Information System (INIS)

    Ha, Ki-Tae; Kim, June-Ki; Lee, Young-Choon; Kim, Cheorl-Ho

    2004-01-01

    Daesungki-Tang (DST), a drug preparation consisting of four herbs, that is, Rhei radix et rhizoma (RR; the roots of Rheum coreanum Nakai, Daehwang in Korean), Aurantiii frutus immaturus (AFI; immature fruits of Poncirus trifolita Rafin., Jisil in Korean), Magnoliae cortex (MC; the stem bark of Magnolia officinalis Rehd. Et Wils., Hubak in Korean), and Mirabilite (MS; Matrii sulfas, Mangcho in Korean), is a traditional Korean herbal medicine that is widely used in the treatment of cancer metastasis, gastrointestinal complaints, vascular disorders, and atherosclerosis-related disorders. In this study, water extracts of DST and each of the four ingredient herbs were prepared. The extracts were tested for cytotoxic activity on human hepatocellular carcinoma cells, Hep3B cells using the XTT assay method. The inhibitory effect of the extracts on the invasion of Hep3B cells was also tested using matrigel precoated transwell chambers. DST effectively inhibited the invasion of Hep3B cells, compared with the control groups in a dose-dependent manner. In addition, a gelatin zymography assay showed that DST decreased the gelatinolytic activity of matrix metalloproteinases-2 (MMP-2; IC 50 = 87 μg/ml) and -9 (MMP-9; IC 50 = 75 μg/ml) that are secreted from Hep3B cells, respectively. Among the four herbal ingredients of DST, only MC has been shown to significantly inhibit the invasion of Hep3B cells and MMP-2 and -9 activities. From these results, it can be concluded that DST has some potential for use as an antitumor agent

  20. A randomized, double-blind, placebo-controlled trial of a traditional herbal formula, Yukmijihwang-tang in elderly subjects with xerostomia.

    Science.gov (United States)

    Han, Gajin; Ko, Seok-Jae; Kim, Juyeon; Oh, Ja-Young; Park, Jae-Woo; Kim, Jinsung

    2016-04-22

    Yukmijihwang-tang (YMJ) is a typical herbal formula to treat Yin-deficiency (YD) syndrome by enriching the fluid-humor of the body. YMJ has been used to treat dry mouth symptoms for hundreds of years in traditional East Asian medicine. Xerostomia, a subjective oral dryness, is common in the elderly and results in impaired quality of life. Many conventional treatments for xerostomia provide only temporary symptom relief, and have side effects. The aim of this study is to investigate the efficacy and safety of YMJ for the treatment of xerostomia in the elderly. This study was designed as a randomized, placebo-controlled, double-blinded, two center trial. Ninety-six subjects aged 60-80 years who had experienced xerostomia for at least 3 months and presented with score>40 on the visual analog scale (VAS) for subjective oral dryness were recruited and randomly allocated to YMJ and placebo groups. YMJ or placebo was administered to each group for 8 weeks (3g of YMJ or placebo, three times per day). The primary outcome was change of VAS for xerostomia from 0 to 8 weeks. VAS for xerostomia was decreased by 22.04±22.76 in the YMJ group and 23.58±23.04 in the placebo group. YMJ had no effect on xerostomia. However, participants with BMIs lower than 29.37kg/m(2) showed improvement of xerostomia after 8 weeks of treatment with YMJ compared to placebo. In addition, YMJ improved oral moisture, which is associated with subjective oral dryness in the YMJ group, and the relationship between VAS for xerostomia and YD was significant. A trend was observed in which YMJ improved oral moisture status and subjective oral dryness in elderly subjects with lower BMI and greater tendency toward YD. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  1. Pharmacokinetics difference of multiple active constituents from decoction and maceration of Fuzi Xiexin Tang after oral administration in rat by UPLC-MS/MS.

    Science.gov (United States)

    Zhang, Qian; Ma, Yue-ming; Wang, Zheng-tao; Wang, Chang-hong

    2014-04-01

    Fuzi Xiexin Tang (FXT) is a classic traditional Chinese medicine formula which has been employed in clinical for more than 1800 years. The distinctive preparation method (maceration) recorded in ancient time is different from one in modern clinical practice (decoction). Aim of this study is to investigate the pharmacokinetic difference of alkaloids, flavones and anthraquinones in rats after oral administration of decoction of FXT (DFXT, 30gkg(-1)), maceration of FXT (MFXT, 30gkg(-1)) and decoction of Aconiti Lateralis Radix Preparata (DAR, 6gkg(-1)) by a validated UPLC-MS/MS method. Plasma concentrations and pharmacokinetic parameters of 16 active constituents (aconitine, hypaconitine, mesaconitine, benzoylaconine, benzoylhypaconine, benzoylmesaconine, berberine, palmatine, jatrorrhizine, coptisine, baicalin, wogonin, wogonoside, emodin, aloe-emodin, rhein) in rat were quantified and compared. Different preparative methods resulted in significant difference on exposure and pharmacokinetic characteristics of alkaloids, flavones and anthraquinones from FXT, especially protoberberine alkaloids. Concentrations of monoester-diterpenoid alkaloids were below the LOD in rat plasma after administration of DFXT and MFXT because of the existence of other three herbs from FXT. Maceration could decrease the absorption of flavones while increased the absorption of anthraquinones. Cmax of emodin and rhein were 3.1 and 10.3 times increased, while eliminations of these two constituents were 8.0 and 19.0 times slower after administration of MFXT. Bioavailability of both flavones and anthraquinones increased after administration of MFXT, especially emodin and rhein increasing as much as 13.5 and 20.7 times. Herb-herb interaction between DAR and other three herbs from FXT significantly influenced the exposure of aconitum alkaloids. Copyright © 2014 Elsevier B.V. All rights reserved.

  2. Efficacy and Safety of the Traditional Herbal Medicine, Gamiguibi-tang, in Patients With Cancer-Related Sleep Disturbance: A Prospective, Randomized, Wait-List-Controlled, Pilot Study.

    Science.gov (United States)

    Lee, Jee Young; Oh, Hye Kyung; Ryu, Han Sung; Yoon, Sung Soo; Eo, Wankyu; Yoon, Seong Woo

    2018-06-01

    Sleep disturbance is the second most bothersome symptom in patients with cancer, and it can significantly impair their quality of life. The aim of this study was to investigate the efficacy and safety of the traditional herbal medicine Gamiguibi-tang (GGBT) in patients with cancer-related sleep disturbance. We conducted a prospective, randomized, wait-list-controlled, open-label pilot clinical trial on cancer-related sleep disturbance. Patients with cancer experiencing poor sleep quality with a Pittsburgh Sleep Quality Index of at least 6 were randomly assigned to the GGBT and wait-list groups to receive GGBT and conventional care, respectively, for 2 weeks. The primary endpoint was the Insomnia Severity Index (ISI) score. Fatigue, depression, and cognitive impairment were assessed as the secondary endpoints by using the Brief Fatigue Inventory (BFI), Beck Depression Inventory (BDI), and Montreal Cognitive Assessment (MoCA). Thirty participants who met the eligibility criteria were enrolled. Sleep disturbance assessed using the ISI improved significantly more in the GGBT group than in the wait-list group (-5.5 ± 4.4 vs 0.1 ± 1.1, P < .001). Fatigue level determined using the BFI also improved significantly more in the GGBT group than in the wait-list group (-0.8 ± 0.8 vs 0.0 ± 0.3, P = .002). The BDI and MoCA scores showed no significant changes. Adverse events were reported in two patients in the GGBT group and consisted of mild dyspepsia and mild edema. GGBT may be a potential treatment option for cancer-related sleep disturbance. Further research is needed to investigate the efficacy and safety of GGBT.

  3. Barriers to the adoption of energy-saving technologies in the building sector: A survey study of Jing-jin-tang, China

    International Nuclear Information System (INIS)

    Du, Ping; Zheng, Li-Qun; Xie, Bai-Chen; Mahalingam, Arjun

    2014-01-01

    The building sector of China currently consumes 20% of the total energy consumption. Studies on barriers to the adoption of building energy-saving technologies are of great significance on implementing policies related to achieving energy-saving goals. This paper studied 15 barriers with the aid of information collected through questionnaires and semi-structured interviews. The respondents were 135 employees working in the Jing-jin-tang area. Based on the results of the factor analysis, the barriers were categorized into five groups: attitudes of stakeholders, policies and regulations, auxiliary resources, profitability, and adaptability of the technologies. Analysis of the entire sample showed that the stakeholders’ reluctance to use was the largest barrier, followed by high initial investment and low profitability. Further analysis showed that the occupation and designation of the respondents and the size of the enterprises that they served influenced their perspectives on the barriers. It was found that architects attributed more importance to the adoption of energy-saving technologies than contractors; barriers confronted by employees of large enterprises and small enterprises were different; managers perceived weaker barriers than frontline employees and were more optimistic about the prospect of building energy-saving technologies. Finally, policy recommendations were proposed based on these in-depth and targeted analyses. - Highlights: • Fifteen barriers to the adoption of energy-saving technologies are discussed. • Surveys are conducted in one of China's most technologically developed area. • The barriers are divided into 5 groups according to the results of factor analysis. • Barriers related to profitability greatly hamper the adoption of the technologies. • Comparative analyses show the background of respondents influence their viewpoints

  4. Preconditioning with the traditional Chinese medicine Huang-Lian-Jie-Du-Tang initiates HIF-1α-dependent neuroprotection against cerebral ischemia in rats.

    Science.gov (United States)

    Zhang, Qichun; Bian, Huimin; Li, Yu; Guo, Liwei; Tang, Yuping; Zhu, Huaxu

    2014-06-11

    Huang-Lian-Jie-Du-Tang (HLJDT) is a classical heat-clearing and detoxicating formula of traditional Chinese medicine that is widely used to treat stroke. The present study was designed to investigate the effects of HLJDT preconditioning on neurons under oxygen and glucose deprivation (OGD) and rats subjected to middle cerebral artery occlusion (MCAO). A stroke model of rats was obtained through MCAO. Following HLJDT preconditioning, the cerebral infarction volume, cerebral water content, and neurological deficient score were determined. Cerebral cortical neurons cultured in vitro were preconditioned with HLJDT and then subjected to OGD treatment. The release of lactate dehydrogenase (LDH) from neurons was detected. The levels of hypoxia-inducible factor-1α (HIF-1α) and PI3K/Akt signaling were analyzed by western blotting, and the levels of erythropoietin (EPO) and vascular endothelial growth factor (VEGF) in the supernatant of the neurons and the plasma of MCAO rats were measured through a radioimmunological assay. The apoptosis and proliferation of neurons were analyzed by immunohistochemistry. HLJDT preconditioning significantly reduced the cerebral infarction volume and cerebral water content and ameliorated the neurological deficient score of MCAO rats. In addition, HLJDT preconditioning protected neurons against OGD. Increased HIF-1α, EPO, and VEGF levels and the activation of PI3K/Akt signaling were observed as a result of HLJDT preconditioning. Furthermore, HLJDT preconditioning was found to inhibit ischemia-induced neuron apoptosis and to promote neuron proliferation under conditions of ischemia/reperfusion. Both rats and neurons subjected to HLJDT preconditioning were able to resist ischemia/reperfusion or hypoxia injury through the inhibition of apoptosis and the enhancement of proliferation, and these effects were primarily dependent on the activation of the PI3K/Akt signaling pathway and HIF-1α. Copyright © 2014 Elsevier Ireland Ltd. All rights

  5. San-Huang-Xie-Xin-Tang Prevents Rat Hearts from Ischemia/Reperfusion-Induced Apoptosis through eNOS and MAPK Pathways

    Directory of Open Access Journals (Sweden)

    Shu-Fen Liou

    2011-01-01

    Full Text Available San-Huang-Xie-Xin-Tang (SHXT is a traditional Chinese medication consisting of three herbs, namely Coptidis rhizome, Scutellariae radix and Rhei rhizome. This study aimed to examine the cardioprotective effects of SHXT in a rat model of acute myocardial apoptosis induced by ischemia/reperfusion (I/R. Vehicle (intravenous saline or SHXT (intravenous or oral was administered prior to I/R (occlusion of left coronary artery for 45 min followed by reperfusion for 2 h. In the vehicle group, myocardial I/R caused myocardial infarction with increased plasma cardiac enzymes, severe arrhythmia and mortality. Myocardial apoptosis was induced by I/R as evidenced by DNA ladder and Bcl-2/Bax ratio. In the SHXT group, we found that SHXT significantly reduced plasma levels of cardiac enzymes, arrhythmia scores (from 5 ± 1 to 2 ± 1, P<.01 and mortality rate (from 53 to 0%, P<.01. In addition, pretreatment with intravenous SHXT reduced the infarct size dose-dependently when compared with the vehicle group (10 mg kg−1: 14.0 ± 0.2 versus 44.5 ± 5.0%, and 30 mg kg−1: 6.2 ± 1.2% versus 44.5 ± 5.0%, both P<.01. Similarly, oral administration of SHXT reduced the infarct size dose-dependently. Furthermore, SHXT markedly decreased the apoptosis induced by I/R with increased Bcl-2/Bax ratio. Finally, we found that SHXT counteracted the I/R-induced downstream signaling, resulting in increased myocardial eNOS expression and plasma nitrite, and decreased activation of ERK1/2, p38 and JNK. These data suggest that SHXT has cardioprotective effects against I/R-induced apoptosis, and that these effects are mediated, at least in part, by eNOS and MAPK pathways.

  6. Inhibition of Neoplastic Transformation and Chemically-Induced Skin Hyperplasia in Mice by Traditional Chinese Medicinal Formula Si-Wu-Tang

    Directory of Open Access Journals (Sweden)

    Mandy M. Liu

    2017-03-01

    Full Text Available Exploring traditional medicines may lead to the development of low-cost and non-toxic cancer preventive agents. Si-Wu-Tang (SWT, comprising the combination of four herbs, Rehmanniae, Angelica, Chuanxiong, and Paeoniae, is one of the most popular traditional Chinese medicines for women’s diseases. In our previous studies, the antioxidant Nrf2 pathways were strongly induced by SWT in vitro and in vivo. Since Nrf2 activation has been associated with anticarcinogenic effects, the purpose of this study is to evaluate SWT’s activity of cancer prevention. In the Ames test, SWT demonstrated an antimutagenic activity against mutagenicity induced by the chemical carcinogen 7,12-dimethylbenz(aanthracene (DMBA. In JB6 P+ cells, a non-cancerous murine epidermal model for studying tumor promotion, SWT inhibited epidermal growth factor (EGF-induced neoplastic transformation. The luciferase reporter gene assays demonstrated that SWT suppressed EGF-induced AP-1 and TNF-α-induced NF-κB activation, which are essential factors involved in skin carcinogenesis. In a DMBA-induced skin hyperplasia assay in ‘Sensitivity to Carcinogenesis’ (SENCAR mice, both topical and oral SWT inhibited DMBA-induced epidermal hyperplasia, expression of the proliferation marker Proliferating cell nuclear antigen (PCNA, and H-ras mutations. These findings demonstrate, for the first time, that SWT prevents tumor promoter and chemical-induced carcinogenesis in vitro and in vivo, partly by inhibiting DNA damage and blocking the activation of AP-1 and NF-κB.

  7. Daesiho-Tang Is an Effective Herbal Formulation in Attenuation of Obesity in Mice through Alteration of Gene Expression and Modulation of Intestinal Microbiota.

    Directory of Open Access Journals (Sweden)

    Ahtesham Hussain

    Full Text Available Obesity has become a major global health challenge due to its increasing prevalence, and the associated health risk. It is the main cause of various metabolic diseases including diabetes, hypertension, cardiovascular disease, stroke and certain forms of cancer.In the present study we evaluated the anti-obesity property of Daesiho-tang (DSHT, an herbal medicine, using high fat diet (HFD-induced obese mice as a model. Our results showed that DSHT ameliorated body weight gain, decreased total body fat, regulated expression of leptin and adiponectin genes of adipose tissue and exerted an anti-diabetic effect by attenuating fasting glucose level and serum insulin level in HFD-fed animals. In addition, DSHT-treatment significantly reduced total cholesterol (TC, triglycerides (TG and increased high density lipoprotein-cholesterol (HDL, glutamic pyruvic transaminase (GPT and glutamic oxaloacetic transaminase (GOT levels in serum and reduced deposition of fat droplets in liver. DSHT treatment resulted in significantly increased relative abundance of bacteria including Bacteroidetes, Bacteroidetes/Firmicutes ratio, Akkermansia Bifidobacterium., Lactobacillus, and decreased the level of Firmicutes. Using RT2 profiler PCR array, 39 (46% genes were found to be differentially expressed in HFD-fed mice compared to normal control. However, normal gene expressions were restored in 36 (92% genes of HFD-fed mice, when co-exposed to DSHT.The results of this study demonstrated that DSHT is an effective herbal formulation in attenuation of obesity in HFD-fed mice through alteration of gene expressions and modulation of intestinal microbiota.

  8. Teng-Long-Bu-Zhong-Tang, a Chinese herbal formula, enhances anticancer effects of 5--Fluorouracil in CT26 colon carcinoma.

    Science.gov (United States)

    Deng, Shan; Hu, Bing; An, Hong-Mei; Du, Qin; Xu, Ling; Shen, Ke-Ping; Shi, Xiu-Feng; Wei, Meng-Meng; Wu, Yang

    2013-06-08

    Colorectal cancer remains one of the leading causes of cancer death worldwide. Traditional Chinese Medicine (TCM) has played a positive role in colorectal cancer treatment. There is a great need to establish effective herbal formula for colorectal cancer treatment. Based on TCM principles and clinical practices, we have established an eight herbs composed formula for colorectal cancer treatment, which is Teng-Long-Bu-Zhong-Tang (TLBZT). We have demonstrated the anticancer effects of TLBZT against colorectal carcinoma in vitro. In present study, we evaluated the anticancer potential of TLBZT, used alone or in combination with low dose of 5-Fluorouracil (5-Fu), in CT26 colon carcinoma in vivo. CT26 colon carcinoma was established in BALB/c mice and treated with TLBZT, 5-Fu, or TLBZT plus 5-Fu. The tumor volumes were observed. Apoptosis was detected by TUNEL assay. Caspases activities were detected by colorimetric assay. Cell senescence was indentified by senescence β-galactosidase staining. Gene expression and angiogenesis was observed by immunohistochemistry or western blot. TLBZT significantly inhibited CT26 colon carcinoma growth. TLBZT elicited apoptosis in CT26 colon carcinoma, accompanied by Caspase-3, 8, and 9 activation and PARP cleavage, and downregulation of XIAP and Survivin. TLBZT also induced cell senescence in CT26 colon carcinoma, with concomitant upregulation of p16 and p21 and downregulation of RB phosphorylation. In addition, angiogenesis and VEGF expression in CT26 colon carcinoma was significantly inhibited by TLBZT treatment. Furthermore, TLBZT significantly enhanced anticancer effects of 5-Fu in CT26 colon carcinoma. TLBZT exhibited significantly anticancer effect, and enhanced the effects of 5-Fu in CT26 colon carcinoma, which may correlate with induction of apoptosis and cell senescence, and angiogenesis inhibition. The present study provides new insight into TCM approaches for colon cancer treatment that are worth of further study.

  9. Inhibitory effects of Cheongsangbangpoong-tang on both inflammatory acne lesions and facial heat in patients with acne vulgaris: A randomized controlled trial protocol.

    Science.gov (United States)

    Kim, Kyuseok; Kim, Kwan-Il; Lee, Junhee

    2016-01-22

    Due to increasing interest from acne patients concerned about the side effects associated with conventional therapies, complementary and alternative medicine (CAM) has been suggested as a new therapeutic modality for acne vulgaris. Herbal medicine is one of these CAM treatments. Cheongsangbangpoong-tang (CBT) is a common herbal formula used in patients with acne vulgaris in the clinical practice of Korean Medicine (KM). However, despite the common use of CBT in clinical practice, the current level of evidence is insufficient to support an inhibitory effect of CBT on inflammatory acne lesions and facial heat. Therefore, this study was designed to assess the inhibitory effect of CBT on both inflammatory acne lesions and facial heat. A randomized, double-blind, parallel-group, and placebo-controlled trial will be conducted. Fifty-six participants with acne vulgaris will be randomized into one of two groups: the CBT or placebo groups. After randomization, participants will be prescribed either CBT or placebo three times a day at a dose of 5 g after meals for 8 weeks. The following outcome measurements will be used in the examination of subjects: the mean percentage change and the count change of the inflammatory and non-inflammatory acne lesions, the temperature of facial points on digital infrared thermal imaging (DITI), serum cortisol, serum dehydroepiandrosterone-sulfate (DHEA-S), visual analogue scale (VAS), investigator global assessment (IGA), and severity score on the Korean Acne Grading System (KAGS) from baseline to the end of the trial. This trial will provide evidence regarding the inhibitory effect of CBT on inflammatory acne lesions and facial heat. The findings of this trial may have important implications for the more widespread use of CBT for the treatment of acne vulgaris. The trial is registered with the Clinical Research Information Service (CRiS), Republic of Korea: KCT0001468 .

  10. Amelioration of inflammatory responses by Socheongryong-Tang, a traditional herbal medicine, in RAW 264.7 cells and rats.

    Science.gov (United States)

    Park, Sang Mi; Lee, Tae Hoon; Zhao, Rongjie; Kim, Youn Sook; Jung, Ji Yun; Park, Chung A; Jegal, Kyung Hwan; Ku, Sae Kwang; Kim, Jae Kwang; Lee, Chul Won; Kim, Young Woo; Cho, Il Je; An, Won G; Kim, Sang Chan

    2018-05-01

    Socheongryong-Tang (SCRT) is a natural medicine prescription that has been mainly used in East Asia for the treatment of inflammatory disorders, including asthma and allergic rhinitis. The present study evaluated the anti-inflammatory effects of SCRT on lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and in a rat model of carrageenan (CA)-induced paw edema. Levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6 and prostaglandin E2 (PGE2) in the culture supernatant were quantified and nitric oxide (NO) production was monitored. In addition, the effect of SCRT on the protein expression of nuclear factor-κB (NF-κB), mitogen-activated protein kinases (MAPKs), inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) was assessed by western blot analysis. Furthermore, the effects of SCRT on acute inflammation in vivo and changes in the histomorphometry and histopathology of paw skin were observed using CA-treated rats. SCRT (1 mg/ml) inhibited the LPS-induced changes in the protein expression of NF-κB, JNK, ERK1/2, iNOS and COX-2, as well as the production of NO, PGE2 and cytokines. In the rat paw edema assay, administration of 1 g/kg of lyophilized powder obtained from the aqueous extracts of SCRT for 3 consecutive days inhibited the CA-induced increases in skin thickness, mast cell degranulation, and infiltration of inflammatory cells in the ventral and dorsal pedis skin within 4 h. These results demonstrated that SCRT exerts its anti-inflammatory activities in LPS-stimulated RAW 264.7 cells through decreasing the production of inflammatory mediators, including PGE2, NO and cytokines, via suppression of the NF-κB and JNK and ERK1/2 signaling pathways. In addition, the data of the CA-induced paw edema indicated an anti-edema effect of SCRT. SCRT (1 g/kg) reduced acute edematous inflammation through inhibition of mast cell degranulation and infiltration of inflammatory cells. Therefore, the present study provided scientific evidence for

  11. Novel biotransformation process of podophyllotoxin to 4 β-sulfur-substituted podophyllum derivates with anti-tumor activity by Penicillium purpurogenum Y.J. Tang.

    Science.gov (United States)

    Bai, J-K; Zhao, W; Li, H-M; Tang, Y-J

    2012-01-01

    According to the structure-function relationship of podophyllotoxin (PTOX) and its analogue of 4'- demethylepipodophyllotoxin (DMEP), the 4 β-substitution of sulfur-containing heterocyclic compounds with a carbon-sulfur bond at 4 position of PTOX or DMEP is an essential modification direction for improving the anti-tumor activity. So, four novel 4 β-sulfursubstituted podophyllum derivatives (i.e., 4β -(1,2,4-triazole-3-yl)sulfanyl-4-deoxy-podophyllotoxin (4-MT-PTOX), 4β-(1,3,4- thiadiazole-2-yl)sulfanyl-4-deoxy-podophyllotoxin (4-MTD-PTOX), 4β-(1,2,4-triazole-3-yl)sulfanyl-4-deoxy-4' -demethylepipodophyllotoxin (4-MT-DMEP), and 4β-(1,3,4-thiadiazole-2-yl)sulfanyl-4-deoxy-4'-demethylepipodophyllotoxin (4-MTD-DMEP)) were designed and then successfully biosynthesized in this work. In the novel sulfur-substituted biotransformation processes, PTOX and DMEP was linked with sulfur-containing compounds (i.e., 3-mercapto-1,2,4-triazole (MT) and 2-mercapto-1,3,4-thiadiazole (MTD)) at 4 position of cycloparaffin to produce 4-MT-PTOX (1), 4-MTD-PTOX (2), 4-MT-DMEP (3), and 4-MTD-DMEP (4) by Penicillium purpurogenum Y.J. Tang, respectively, which was screened out from Diphylleia sinensis Li (Hubei, China). All the novel compounds exhibited promising in vitro bioactivity, especially 4-MT-PTOX (1). Compared with etoposide (i.e., a 50 % effective concentration [EC(50)] of 25.72, 167.97, and 1.15 M), the EC(50) values of 4-MT-PTOX (1) against tumor cell line BGC-823, A549 and HepG2 (i.e., 0.28, 0.76, and 0.42 M) were significantly improved by 91, 221 and 2.73 times, respectively. Moreover, the EC(50) value of 4-MT-PTOX (1) against the normal human cell line HK-2 (i.e., 182.4 μM) was 19 times higher than that of etoposide (i.e., 9.17 μM). Based on the rational design, four novel 4 β-sulfur-substituted podophyllum derivatives with superior in vitro anti-tumor activity were obtained for the first time. The correctness of structure-function relationship and rational drug

  12. Chemical profile analysis and comparison of two versions of the classic TCM formula Danggui Buxue Tang by HPLC-DAD-ESI-IT-TOF-MSn.

    Science.gov (United States)

    Zhang, Ya-Zhou; Xu, Feng; Yi, Tao; Zhang, Jian-Ye; Xu, Jun; Tang, Yi-Na; He, Xi-Chen; Liu, Jing; Chen, Hu-Biao

    2014-04-30

    Danggui Buxue Tang (DBT) is a Traditional Chinese Medicine (TCM) formula primarily used to treat symptoms associated with menopause in women. Usually, DBT is composed of one portion of Radix Angelicae Sinensis (RAS) and five portions of Radix Astragali (RA). Clinically, Radix Hedysari (RH) is sometimes used by TCM physicians to replace RA in DBT. In order to verity whether the chemical constituents of the DBT1 (RA:RAS = 5:1, w/w) and DBT2 (RH:RAS = 5:1, w/w) share similarities the chemical profiles of the two DBTs crude extracts and urine samples were analyzed and compared with the aid of HPLC-DAD-ESI-IT-TOF-MSn, which determines the total ion chromatogram (TIC) and multi-stage mass spectra (MSn). Then, the DBT1 and DBT2 were identified and compared on the basis of the TIC and the MSn. In the first experiment (with crude extracts), 69 compounds (C1-C69) were identified from the DBT1; 46 compounds (c1-c46) were identified from the DBT2. In the second experiment(with urine samples), 44 compounds (M1-M44) were identified from the urine samples of rats that had been administered DBT1, and 34 compounds (m1-m34) were identified from the urine samples of rats that had been administered DBT2. Identification and comparison of the chemical compositions were carried out between the DBT1 and DBT2 of the crude extracts and urine samples respectively. Our results showed that the two crude extracts of the DBTs have quite different chemical profiles. The reasons for their differences were that the special astragalosides in DBT1 and the isoflavonoid glycosides formed the malonic acid esters undergo single esterification and acetyl esters undergo acetylation in DBT1. In contrast, the urine from DBT1-treated rats strongly resembled that of DBT2-treated rats. These metabolites originate mainly from formononetin, calycosin and their related glycosides, and they were formed mainly by the metabolic process of reduction, deglycosylation, demethylation, hydrogenation and sulfation. The

  13. Yan Sun, Corruption and Market in Contemporary China, Ithaca (N.Y.), Cornell University Press, 2004 et Ning Wang, Making a Market Economy. The Institutional Transformation of a Freshwater Fishery in a Chinese Community, Londres et New York, Routledge, 200

    OpenAIRE

    Guiheux, Gilles

    2008-01-01

    Ces deux ouvrages éclairent les conditions dans lesquelles, au cours des 25 dernières années, l’économie de commande a été démantelée et remplacée progressivement par un système de marché. Yan Sun, professeur de sciences politiques, s’intéresse à la corruption dans une double perspective macro et micro. Ning Wang, économiste néo-institutionnaliste, se demande comment, à la faveur des réformes, une région (Jingzhou, au sud du Hubei) s’est convertie à la pisciculture. La corruption est une ques...

  14. IN VIVO EFFECT OF GUIDING-HERB RADIX PLATYCODONIS AND RADIX CYATHULAE ON PAEONIFLORIN PHARMACOKINETICS OF XUEFU ZHUYU TANG IN RATS.

    Science.gov (United States)

    Tang, Song-Qi; Chen, Yun-Hui; Chen, Xi-Ping; Zhang, Xiao-Dan; Huang, Wei

    2017-01-01

    Xuefu Zhuyu Tang (XFZYT), first recorded in Correction of Errors in Medical Works by Qing-ren Wang, has been proven reliable and effective for curing various diseases such as atherosclerosis, hypertension, hyperlipidemia, and angina pectoris. It consists of 11 herbs and two of them, Radix platycodonis and Radix cyathulae , have been traditionally considered as guiding herbs and deeply valued by tens of millions of Chinese medicine practitioners. Do Radix platycodonis and Radix cyathulae affect the pharmacokinetics of the effective constituent-paeoniflorin of XFZYT? If yes, in what way? This study aims to answer these questions. The medicinal solutions of XFZYT, XFZYT without Radix platycodonis (XFZYT-JG), XFZYT without Radix cyathulae (XFZYT-NX), and XFZYT without Radix platycodonis and Radix cyathulae (XFZYT-JG-NX) were prepared and administrated to rats in the normal group and the blood-stasis model group by gavage, respectively. The blood samples of rats in the normal group were obtained 5, 10, 15, 20, 30, 45, 60, 120, and 240 minutes after gavage; whereas the blood samples of rats in the blood-stasis model group were obtained 10, 15, 20, 30, 45, 90, 150, and 240 minutes after gavage. Biological samples were processed; the assays of specificity, precision, linearity, intra-day and inter-day precisions, recovery and stability were conducted; high performance liquid chromatography was performed to detect paeoniflorin content; and DAS software was adopted to generate pharmacokinetic parameters. Mobile phase was composed of acetonitrile and water (16:84), detection wavelength was 230 nm, and riboflavin was set as internal standard substance. The pharmacokinetic parameters of the rats in the normal group after oral gavage of XFZYT, XFZYT-JG, XFZYT-NX, and XFZYT-JG-NX were C max = (0.363±0.248, 0.065±0.020, 0.099±0.033, 0.099±0.020) mg/L, T max = (0.276±0.084, 0.583±0.342, 0.555±0.228, 0.317±0.033)h, t 1/2 = (0.501±0.241, 1.021±0.522, 0.853±0.377, 1.227±0

  15. Treating acute ankle sprain by the Tongde Ning plus elastic bandage%痛得宁加减熬膏外敷结合弹力绷带外固定治疗急性踝关节扭伤

    Institute of Scientific and Technical Information of China (English)

    郑一非

    2015-01-01

    Objective:To observe effects of Tongde Ning plus elastic bandage on acute ankle sprain. Methods:Through retrospective study, 56 cases of acute ankle sprain were selected;30 cases were male, and 26 cases were female, 28 to 52 years old. The average age was (34.5±1.4) years. 56 cases of acute ankle sprain were randomly divided into treatment group and control group, each group for 28 cases. Patients in the treatment group received Tongde Ning plus elastic bandage, and patients in the control group received elastic bandage only. Results: After the treatment, the course of disease in both groups appeared obvious difference,P<0.05. In the treatment group, 20 cases (71.4%) were cured; 8 cases (28.6%) were better. In the control group, 9 cases (32.1%) were cured; 18 cases (64.3%) were better; 1 case (3.6%) were ineffective. Conclusion:Tongde Ning applied plus elastic bandage were highly effective on acute ankle sprain, and worthy of promotion.%目的:研究痛得宁加减熬膏外敷结合弹力绷带外固定治疗急性踝关节扭伤的疗效。方法:选择回顾性研究方法,选取2014年2-5月之间来沈阳市骨科医院进行急性踝关节扭伤治疗的患者56例,其中男30例,女26例,年龄28~52岁,平均年龄(34.5±1.4)岁。按1∶1的随机方式分为治疗组和对照组,每组28人。治疗组为外敷中药膏剂加弹力绷带外固定组,对照组为单纯弹力绷带外固定组。结果:治疗组与对照组经治疗后,病程时间比较有明显差异,P<0.05;治疗组治愈20人(71.4%),好转8人(28.6%),未愈0人(0.0%);对照组治愈9人(32.1%),好转18人(64.3%),未愈1人(3.6%)。结论:痛的宁加减熬膏外敷结合弹力绷带外固定治疗急性踝关节扭伤疗效确切,值得推广应用。

  16. Computerteknologi og kognitiv genoptræning

    DEFF Research Database (Denmark)

    Wilms, Inge Linda

    2009-01-01

    Danmark er et af de lande, hvor flest indbyggere har adgang til en computer. De fleste danskere anvender computeren dagligt på arbejde og hjemme til bl.a. chat, blog, videnssøgning, handel, spil og kommunikation. Hvordan kan det så være, at der er så lille udbredelse af computerbaserede rehabilit...

  17. Combination of counterpropagation artificial neural networks and antioxidant activities for comprehensive evaluation of associated-extraction efficiency of various cyclodextrins in the traditional Chinese formula Xue-Zhi-Ning.

    Science.gov (United States)

    Sun, Lili; Yang, Jianwen; Wang, Meng; Zhang, Huijie; Liu, Yanan; Ren, Xiaoliang; Qi, Aidi

    2015-11-10

    Xue-Zhi-Ning (XZN) is a widely used traditional Chinese medicine formula to treat hyperlipidemia. Recently, cyclodextrins (CDs) have been extensively used to minimize problems relative to medicine bioavailability, such as low solubility and poor stability. The objective of this study was to determine the associated-extraction efficiency of various CDs in XZN. Three various type CDs were evaluated, including native CDs (α-CD, β-CD), hydrophilic CD derivatives (HP-β-CD and Me-β-CD), and ionic CD derivatives (SBE-β-CD and CM-β-CD). An ultra high-performance liquid chromatography (UHPLC) fingerprint was applied to determine the components in CD extracts and original aqueous extract (OAE). A counterpropagation artificial neural network (CP-ANN) was used to analyze the components in different extracts and compare the selective extraction of various CDs. Extraction efficiencies of the various CDs in terms of extracted components follow the ranking, ionic CD derivatives>hydrophilic CD derivatives>native CDs>OAE. Besides, different types of CDs have their own selective extraction and ionic CD derivatives present the strongest associated-extraction efficiency. Antioxidant potentials of various extracts were evaluated by determining the inhibition of spontaneous, H2O2-induced, CCl4-induced and Fe(2+)/ascorbic acid-induced lipid peroxidation (LPO) and analyzing the scavenging capacity for DPPH and hydroxyl radicals. The order of extraction efficiencies of the various CDs relative to antioxidant activities is as follows: SBE-β-CD>CM-β-CD>HP-β-CD>Me-β-CD>β-CD>α-CD. It can be demonstrated that all of the CDs studied increase the extraction efficiency and that ionic CD derivatives (SBE-β-CD and CM-β-CD) present the highest extraction capability in terms of amount extracted and antioxidant activities of extracts. Copyright © 2015 Elsevier B.V. All rights reserved.

  18. Influence of Jiang Tang Bu Shen Fang on expression of IKKβ mRNA in diabetic rats%降糖补肾方对糖尿病大鼠IKKβ mRNA表达的影响

    Institute of Scientific and Technical Information of China (English)

    范冠杰; 孙晓泽; 唐咸玉; 孙璐; 曾星; 罗广波; 卢绮韵; 温建炫

    2011-01-01

    目的 观察降糖补肾方对小剂量链脲佐菌素(STZ)加高脂饲料诱导的糖尿病模型大鼠肌肉组织IKK激酶β(IKKβ)信使核糖核酸(mRNA)表达的影响.方法 雄性SD大鼠高脂饲料喂养4周后注射小剂量STZ,1周后测大鼠空腹血糖,血糖值>11.1 mmoL/L者为造模成功的大鼠,将造模成功的大鼠随机分为模型组和降糖补肾方干预组,另设阿司匹林对照组和空白对照组,药物干预4周,取大腿肌肉组织,采用聚合酶链反应逆转录RT-PCR技术检测IKKβ mRNA表达水平.结果 模型组IKKβ mRNA表达明显高于空白对照组,是空白对照组的5.098倍(P0.05.结论 降糖补肾方在一定程度上能抑制糖尿病大鼠IKKβ mRNA基因,这可能是降糖补肾方抑制炎症信号通路的传导而发挥其改善胰岛素抵抗治疗糖尿病的机制之一.%Objective To observe the influence of Jiang Tang Bu Shen Fang on the expression of I kappa P kinase (IKKp) mRNA in muscular tissue in diabetic rats induced by low-dose streptozotocin ( STZ) and high-fat diet (HFD). Methods Male SD rats were fed HFD for 4 weeks, and then injected low-dose STZ. After one week the level of fasting plasma glucose was detected in rats and those with higher than 11. 1 mmol/L of level of fasting plasma glucose were successfully modeled. The rats were randomly divided into the model group, low-dose, mid-dose and high-dose Jiang Tang Bu Shen Fang groups (low-dose, mid-dose and high-dose groups), aspirin group and blank group. All groups were intervened by relevant medicinal for 4 weeks. The expression of IKKp mRNA in muscular tissue was detected by using reverse transcription polymerase chain reaction (RT-PCR). Results The expression of IKKp mRNA in the model group was significantly higher than that in the blank group (5.098 times, P 0. 05 compared with that in the model group. Conclusion Jiang Tang Bu Shen Fang can inhibit IKK(3 mRNA to some extent in diabetic rats, which may be one of mechanisms of the

  19. Bu-Shen-Ning-Xin decoction: inhibition of osteoclastogenesis by abrogation of the RANKL-induced NFATc1 and NF-κB signaling pathways via selective estrogen receptor α

    Directory of Open Access Journals (Sweden)

    Wang L

    2015-07-01

    Full Text Available Ling Wang,1,2,* Xue-Min Qiu,1,2,* Yu-Yan Gui,1,2 Ying-Ping Xu,1,2 Hans-Jürgen Gober,3 Da-Jin Li11Laboratory for Reproductive Immunology, Hospital and Institute of Obstetrics and Gynecology, IBS, Fudan University Shanghai Medical College, 2Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, People’s Republic of China; 3Department of Pharmacy, Wagner Jauregg Hospital and Children’s Hospital, Wagner Jauregg Weg, Linz, Austria*These authors contributed equally to this workIntroduction: Bu-Shen-Ning-Xin decoction (BSNXD is a traditional Chinese medicinal composition that has been used as a remedy for postmenopausal osteoporosis, but the mechanisms affecting bone metabolism are not fully understood.Purpose: We investigated the molecular mechanism and signaling pathway underlying the effect of BSNXD on osteoclastogenesis.Materials and methods: A postmenopausal osteoporosis animal model generated by ovariectomy was administered BSNXD and drug-derived serum was prepared. An enzyme immunoassay was conducted to measure the 17-β-estradiol (E2 concentration in the drug-derived serum. Bone marrow-derived monocyte/macrophage precursor cells were treated with drug-derived serum, and tartrate-resistance acid phosphatase staining was conducted to observe osteoclastogenesis. A bone resorption assay was performed to analyze the effect on osteoclastic resorptive function. Real-time PCR, flow cytometry, Western blotting, transfection, and luciferase assays were conducted to explore the related mechanism.Results: E2 was not elevated in BSNXD-derived serum. BSNXD-derived serum suppressed receptor activation of nuclear factor κB ligand (RANKL-activated osteoclastogenesis in a dose-dependent manner; this effect could be reversed by estrogen receptor α antagonist methyl-piperidino-pyrazole. The serum suppressed RANKL-induced NF-κB transcription and inhibited the accumulation of nuclear factor of activated T-cells, cytoplasmic 1

  20. A rapid method for simultaneous determination of 52 marker compounds in Xiao-Qing-Long-Tang by ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.

    Science.gov (United States)

    Zhou, Lei; Qi, Wen; Xu, Cong; Makino, Toshiaki; Yuan, Dan

    2014-11-01

    Xiao-Qing-Long-Tang (XQLT) is a classical Chinese medicine formula. It is generally used for the treatment of common cold, bronchial asthma, and allergic rhinitis in Asia. In this study, a multicomponent quantification fingerprinting approach based on ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry has been developed for the analysis of compounds in XQLT in 14.5 min. A total of 52 compounds were identified by co-chromatography of sample extract with authentic standards and comparing the retention time, UV spectra, molecular ions and characteristic fragment ions with those of authentic standards, or tentatively identified by MS(E) determination along with Mass Fragment software. Moreover, the method was validated for the simultaneous quantification of 16 components in XQLT commercial products. The method is practical for comprehensive standardization of XQLT and holistic comparison of its commercial products from different manufacturers. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. A relação entre as crenças verbalizadas e depreendidas das ações do professor de Língua Inglesa no que tange ao ensino mediado pelas novas tecnologias

    Directory of Open Access Journals (Sweden)

    Kássia Gonçalves Arantes

    2012-12-01

    Full Text Available O objetivo deste trabalho é investigar a relação entre o dizer e o fazer do professor, no que tange à influência das novas tecnologias no ensino e aprendizagem de língua inglesa, bem como identificar os fatores que se articulam para o estabelecimento dessa relação. Para tanto, fazemos o confronto entre as crenças manifestadas no dizer do professor e as crenças depreendidas de seu fazer. Inserida numa perspectiva predominantemente qualitativa de cunho interpretativista, a pesquisa adota uma abordagem contextual de investigação de crenças de professores. O trabalho é fundamentado teoricamente em estudos que abordam as crenças de professores, o papel das novas tecnologias nos processos de ensino e aprendizagem de língua estrangeria, e a relação entre o professor reflexivo e a utilização das novas tecnologias. Os principais resultados encontrados apontam predominantemente para uma relação de dissonância entre o dizer e o fazer dos professores, e os fatores articuladores dessa relação se enquadram em quatro classes, a saber: fatores contextuais, experienciais, cognitivos e afetivos.

  2. Qualitative and quantitative characterization of secondary metabolites and carbohydrates in Bai-Hu-Tang using ultraperformance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry and ultraperformance liquid chromatography coupled with photodiode array detector.

    Science.gov (United States)

    Zhong, Wei-Fang; Tong, Wing-Sum; Zhou, Shan-Shan; Yip, Ka-Man; Li, Song-Lin; Zhao, Zhong-Zhen; Xu, Jun; Chen, Hu-Biao

    2017-10-01

    Bai-Hu-Tang (BHT), a classic traditional Chinese medicine (TCM) formula used for clearing heat and promoting body fluid, consists of four traditional Chinese medicines, i.e., Gypsum Fibrosum (Shigao), Anemarrhenae Rhizoma (Zhimu), Glycyrrhizae Radix et Rhizoma Praeparata cum Melle (Zhigancao), and nonglutinous rice (Jingmi). The chemical composition of BHT still remains largely elusive thus far. To qualitatively and quantitatively characterize secondary metabolites and carbohydrates in BHT, here a combination of analytical approaches using ultraperformance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry and ultraperformance liquid chromatography coupled with photodiode array detector was developed and validated. A total of 42 secondary metabolites in BHT were tentatively or definitely identified, of which 10 major chemicals were quantified by the extracting ion mode of quadrupole time-of-flight mass spectrometry. Meanwhile, polysaccharides, oligosaccharides, and monosaccharides in BHT were also characterized via sample pretreatment followed by sugar composition analysis. The quantitative results indicated that the determined chemicals accounted for 35.76% of the total extract of BHT, which demonstrated that the study could be instrumental in chemical dissection and quality control of BHT. The research deliverables not only laid the root for further chemical and biological evaluation of BHT, but also provided a comprehensive analytical strategy for chemical characterization of secondary metabolites and carbohydrates in traditional Chinese medicine formulas. Copyright © 2017. Published by Elsevier B.V.

  3. Qualitative and quantitative characterization of secondary metabolites and carbohydrates in Bai-Hu-Tang using ultraperformance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry and ultraperformance liquid chromatography coupled with photodiode array detector

    Directory of Open Access Journals (Sweden)

    Wei-Fang Zhong

    2017-10-01

    Full Text Available Bai-Hu-Tang (BHT, a classic traditional Chinese medicine (TCM formula used for clearing heat and promoting body fluid, consists of four traditional Chinese medicines, i.e., Gypsum Fibrosum (Shigao, Anemarrhenae Rhizoma (Zhimu, Glycyrrhizae Radix et Rhizoma Praeparata cum Melle (Zhigancao, and nonglutinous rice (Jingmi. The chemical composition of BHT still remains largely elusive thus far. To qualitatively and quantitatively characterize secondary metabolites and carbohydrates in BHT, here a combination of analytical approaches using ultraperformance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry and ultraperformance liquid chromatography coupled with photodiode array detector was developed and validated. A total of 42 secondary metabolites in BHT were tentatively or definitely identified, of which 10 major chemicals were quantified by the extracting ion mode of quadrupole time-of-flight mass spectrometry. Meanwhile, polysaccharides, oligosaccharides, and monosaccharides in BHT were also characterized via sample pretreatment followed by sugar composition analysis. The quantitative results indicated that the determined chemicals accounted for 35.76% of the total extract of BHT, which demonstrated that the study could be instrumental in chemical dissection and quality control of BHT. The research deliverables not only laid the root for further chemical and biological evaluation of BHT, but also provided a comprehensive analytical strategy for chemical characterization of secondary metabolites and carbohydrates in traditional Chinese medicine formulas.

  4. Evaluation on the concentration change of paeoniflorin and glycyrrhizic acid in different formulations of Shaoyao-Gancao-Tang by the tri-level infrared macro-fingerprint spectroscopy and the whole analysis method

    Science.gov (United States)

    Liu, Aoxue; Wang, Jingjuan; Guo, Yizhen; Xiao, Yao; Wang, Yue; Sun, Suqin; Chen, Jianbo

    2018-03-01

    As a kind of common prescriptions, Shaoyao-Gancao-Tang (SGT) contains two Chinese herbs with four different proportions which have different clinical efficacy because of their various components. In order to investigate the herb-herb interaction mechanisms, we used the method of tri-level infrared macro-fingerprint spectroscopy to evaluate the concentration change of active components of four SGTs in this research. Fourier transform infrared spectroscopy (FT-IR) and Second derivative infrared spectroscopy (SD-IR) can recognize the multiple prescriptions directly and simultaneously. 2D-IR spectra enhance the spectral resolution and obtain much new information for discriminating the similar complicated samples of SGT. Furthermore, the whole analysis method from the analysis of the main components to the specific components and the relative content of the components may evaluate the quality of TCM better. Then we concluded that paeoniflorin and glycyrrhizic acid were the highest proportion in active ingredients in SGT-12:1 and the lowest one in SGT-12:12, which matched the HPLC-DAD results. It is demonstrated that the method composed by the tri-level infrared macro-fingerprint spectroscopy and the whole analysis can be applicable for effective, visual and accurate analysis and identification of very complicated and similar mixture systems of traditional Chinese medicine.

  5. Sip-jeon-dea-bo-tang, a traditional herbal medicine, ameliorates cisplatin-induced anorexia via the activation of JAK1/STAT3-mediated leptin and IL-6 production in the fat tissue of mice.

    Science.gov (United States)

    Woo, Sang-Mi; Choi, Youn Kyung; Kim, Ah-Jeong; Yun, Yee Jin; Shin, Yong Cheol; Cho, Sung-Gook; Ko, Seong Gyu

    2016-04-01

    Despite its therapeutic advantages, chemotherapy can also cause adverse effects, including anorexia and loss of appetite. Although numerous patients with cancer have been reported to suffer from anorexia during or following chemotherapy, treatment options for anorexia remain to be determined. In Asian countries, traditional medicines are widely used to treat problems with appetite; sip-jeon-dea-bo-tang (SJDBT) is one of those medicines used for the treatment of anorexia. The present study demonstrated that SJDBT ameliorated cisplatin-induced anorexia. In a mouse model of chemotherapy-induced anorexia, oral administration of SJDBT prevented the cisplatin-induced reduction of food intake, inhibiting weight loss. The results of multiplex assays showed that SJDBT only altered the levels of interleukin (IL)-6 and leptin in the serum and fat tissue. In addition, SJDBT maintained the serum leptin level and increased the serum IL-6 level, whereas cisplatin reduced the levels of both serum leptin and IL‑6. Furthermore, SJDBT was revealed to increase the levels of leptin and IL-6 in the fat tissue by activating the JAK1/STAT3 signaling pathway. In conclusion, the present results revealed that SJDBT ameliorated cisplatin-induced anorexia, suggesting its usefulness in the prevention of anorexia during chemotherapy.

  6. The herbal decoction modified Danggui Buxue Tang attenuates immune-mediated bone marrow failure by regulating the differentiation of T lymphocytes in an immune-induced aplastic anemia mouse model.

    Directory of Open Access Journals (Sweden)

    Peiying Deng

    Full Text Available Angelicae Sinensis, Radix Astragali and Rhizoma Coptidis are all herbs of modified Danggui Buxue Tang (DGBX and are extensively applied herbs in traditional Chinese medicine for the treatment of anemia and inflammation. In this study, immune-induced AA mice were used as an animal model, and the immunosuppressive agent, Ciclosporin A (CsA, was used as a positive control. Multiple pro-inflammatory cytokines were examined by bead-based multiplex flow cytometry. The T-cell subsets were assessed using a fluorescence-activated cell sorter (FACS. Western blot analysis was used to estimate the protein expression levels of specific transcription factors for T helper cells (Th1, Th2 and Th17 and key molecules of the Janus-activated kinase (Jak/signal transducer and activator of transcription (Stat3 signaling pathway. DGBX treatment could significantly increase the production of whole blood cells in peripheral blood (PB; inhibit the expansion of Th1 and Th17 cells; increase the differentiation of Th2 and Tregs cells; regulate the expression levels of T-bet, GATA-3, RORγ and proinflammatory cytokines; and decrease the expression levels of key molecules in the Jak/Stat signaling pathway. These results indicate that DGBX can regulate the differentiation of T lymphocytes, resulting in immunosuppressive and hematogenic functions on AA mice. DGBX might be a good candidate for inclusion in a randomized study for AA with more data on the possible side effects and doses used in humans. Ultimately, it may be used for applications of traditional medicine against AA in modern complementary and alternative immunosuppressive therapeutics.

  7. Between Faith and Utilitarian: the Scholars' Wild State of Mind in the Middle and Late Tang Dynasty%信仰与功利之间:中晚唐文人的狂放心态

    Institute of Scientific and Technical Information of China (English)

    董春林

    2012-01-01

    唐中后期文人狂放、超脱的个性,虽然常常出现在诗文书写之中,但由于佛教南宗禅的广泛传播,往往被后世研究者归因为信仰的影响,其中儒家传统的出世观念,则常常被所谓的禅理遮蔽。通过对这一时期文人狂放行为特征的剖析,发现文人的超脱只是建构在人世遭遇与个人信仰交点之上的外在处世方式,投影到社会价值观念转型之时,超脱更多地彰显着士大夫文人即时的功利心态,而天命至上的伦理观业已消弭在信仰与现实之间。%The scholars in the Middle and Late Tang Dynasty were unconventional and unrestrained, which often ap- peared in the writing of poetry. But with the wide spread of southern sect zen of buddhism, later generations of re- seaxchers ascribe it to the influence of faith, in which the traditional idea of confucianism' s being born is often shiel- ded by the so-called Buddhism. Through the analysis of the scholar' s wild behavior characteristic in this period, we find the scholars' unconventionality is based on the way of communicating of the intersection point between personal experience and belief. When unconventionality is put into the transformation of social value, it more reveals the litera- ti and offieialdoms' immediate utilitarian mentality. However, the ethics of destiny has disappeared between belief and reality.

  8. Tang Qunying's Personality and Its Influence from the Perspective of Appeal for Suffrage Movement%从参政权诉求运动看唐群英的个性及其影响

    Institute of Scientific and Technical Information of China (English)

    肖宗志

    2012-01-01

    在近代,有相当多的先进分子为争取女权做了不懈的努力,其中有位杰出女性就是衡山人唐群英。中华民国甫立,她即多次直接领导了妇女参政权诉求的运动,但最终归于失败。文章从心理学的视角着力对唐群英参政权诉求言行中所凸显出来的个性特征进行概括,并分析其个性形成与发展的社会原因,论证她的这种个性对妇女参政权诉求运动的双重影响。%In modern times, a considerable number of advanced persons had made unremitting efforts on feminism. One of the outstanding women was Tang Qunying who was from Hengshan County. She directly led several movements of appeal for women' s suf- frage soon after the establishment of Republic of China. But she ultimately failed. The article generalizes Tang's personality manifested from her words and deeds when appealing for suffrage from the psychological perspective. It also analyzes the social reasons for the for- mation and development of Tang's personality. Then it demonstrates its dual influences on the movements of appeal for women' s suf- frage.

  9. Investigation on the pearl roundel patterns of religious implication on the fabric collected in Japan during Tang dynasty%日本藏唐代时期丝路宗教联珠纹织物纹样考

    Institute of Scientific and Technical Information of China (English)

    程雅娟

    2018-01-01

    A lot of relics left after the fabrics with pearl roundel patterns were exported to Japan arouse little public interest. These special religious fabrics with pearl roundel pattern are of great significance to the study on the silk trade and religious exchanges between Europe and Asia. This paper compared the existing fabrics with pearl roundel pattern in Japan with the fabrics with pearl roundel pattern unearthed in the Central Plains and Central Asia, and carried out classification analysis in the context of silk trade exchanges and religious communication between Europe and Asia by the methods of literature and history,archaeology and iconology. The conclusions will fill in the gaps in the study on fabrics with religious pearl roundel pattern in China. The study showed that the silk customization trade in the Sui and Tang dynasties were very specialized and segmented and began to be subdivided according to different religions. The creators of these fabrics were likely to be Sogdians believing in Zoroastrianism in Centra Asia or Sogdians living in the Central Plains.%丝路联珠纹织物东渡入日后留下了大量遗珍,却甚少引起学术关注,这些特殊的宗教联珠纹织物对研究欧亚丝绸贸易与宗教交流具有重要意义.文章将针对日本现存的联珠纹织物纹样与中原、中亚地区出土品进行对比,采用文史、考古学、图像学相关方法,并放置于欧亚大陆丝路贸易交往与宗教传播的背景下进行分类分析,结论将填补国内对于宗教类联珠纹织物的研究空白.研究表明,隋唐时期丝绸订制贸易已非常专业化与细分化,开始针对不同宗教教徒进行纹饰细分,织造者极有可能为信仰琐罗亚斯德教的中亚粟特人或生活在中原的粟特人.

  10. Tööstusomandi õiguskaitse / Eve Tang

    Index Scriptorium Estoniae

    Tang, Eve

    2005-01-01

    Nimestik Eesti tööstusomandi valdkonna õigusaktidest, Patendiameti ametlikest ja metoodilistest väljaannetest, on-line andmebaasidest. Lisatud tabel: Eesti Vabariigi ühinemine rahvusvaheliste lepingutega tööstusomandi valdkonnas

  11. Northern Song Reflections on the Tang

    Science.gov (United States)

    Rice, Jeffrey

    2013-01-01

    In the mid-eleventh century Chinese intellectuals argued about history, and left their competing narratives to us in print. They contested how history should be written, and what relevant lessons ought to be adapted to the changing society of Song (960-1279) dynasty China. They were particularly concerned with the history of the long-lasting Tang…

  12. 2416-IJBCS-Article-Tang Erasmus Nchuafi

    African Journals Online (AJOL)

    hp

    2015 International Formulae Group. ... content, and grain weight during the sampling intervals. ... rice consumption has increased than that of ... handle cocoa beans, are used by rice farmers ... After 5 days, the first count was carried out and the second count on the 14th day. ..... determine the evolution of seed quality in.

  13. Size- and shape-controlled synthesis and catalytic performance of iron-aluminum mixed oxide nanoparticles for NOX and SO₂ removal with hydrogen peroxide.

    Science.gov (United States)

    Ding, Jie; Zhong, Qin; Zhang, Shule; Cai, Wei

    2015-01-01

    A novel, simple, reproducible and low-cost strategy is introduced for the size- and shape-controlled synthesis of iron-aluminum mixed oxide nanoparticles (NIAO(x/y)). The as-synthesized NIAO(x/y) catalyze decomposition of H2O2 yielding highly reactive hydroxyl radicals (OH) for NOX and SO2 removal. 100% SO2 removal is achieved. NIAO(x/y) with Fe/Al molar ratio of 7/3 (NIAO(7/3)) shows the highest NOX removal of nearly 80% at >170°C, whereas much lower NOX removal (oxides in NIAO(7/3) promotes the formation of lamellar products, thus improving the specific surface areas and mesoporous distribution, benefiting the production of OH radicals. Furthermore, the NIAO(7/3) leads to the minor increase of points of zero charges (PZC), apparent enhancement of FeOH content and high oxidizing ability of Fe(III), further improving the production of OH radicals. However, the NIAO(3/7) results in the formation of aluminum surface-enriched spherical particles, thus decreasing the surface atomic ratio of iron oxides, decreasing OH radical production. More importantly, the generation of FeOAl causes the decline of active sites. Finally, the catalytic decomposition of H2O2 on NIAO(x/y) is proposed. And the well catalytic stability of NIAO(7/3) is obtained for evaluation of 30 h. Copyright © 2014 Elsevier B.V. All rights reserved.

  14. Ryder Cup ning rahvusvaheline kogemus teenindusvaldkonnast / Liis Meeras

    Index Scriptorium Estoniae

    Meeras, Liis

    2006-01-01

    Iirimaal Dublini lähedal Kildare maakonna provintsis asuvas K-Clubis 22.-24. septembrini toimunud 36. Ryder Cup turniirist, mis on üks prestiizhikaim golfiüritus maailmas. Oma muljetest räägivad üritusel teenindanud turismitudengid TÜ Pärnu kolledzhist

  15. Genoptræning efter brystkræftkirurgi

    DEFF Research Database (Denmark)

    Kronborg Poulsen, Lise; Høgdal, Nina; Sørensen, Lisbeth Villemoes

    2011-01-01

    The short- and long-term benefits of post-discharge physiotherapy regimens after breast cancer surgery are debatable. A national survey in Denmark performed at hospitals and municipal rehabilitation clinics showed considerable variability in post-breast surgery rehabilitation regimens. As hospital...

  16. Raha ja maa asemel uurimine ning pankrot / Piret Reiljan

    Index Scriptorium Estoniae

    Reiljan, Piret, 1983-

    2010-01-01

    Aserbaidžaani kinnisvaraprojekti investeerinud ärimehed kahtlustavad Tõnis Haavelit investeerimiskelmuses, ärimehed esitasid projektiks võlakirju emiteerinud Seaside Residence Baku vastu pankrotiavalduse

  17. Tu(r)ning weakness to strength: Mechanomutable bioinspired materials

    Science.gov (United States)

    2017-04-03

    building blocks," Philosophical Magazine Letters, Vol. 94, 592-600, 2014. • A.K. Nair, A. Gautieri, M.J. Buehler,"Role of intrafibrillar collagen...release. 4 • S. Cranford, N. Pugno, M.J. Buehler, "Silk and Web Synergy: The Merging of Material and Structural Performance," in: Biotechnology of

  18. Hagi ese ja alus ning hagi muutmine kohtupraktikas / Margit Vutt

    Index Scriptorium Estoniae

    Vutt, Margit, 1968-

    2011-01-01

    Hagi alust ja eset käsitlevast kohtupraktikast. Kohtu selgitamiskohustusest hagi eseme ja aluse õigel määratlemisel. Hagi muutmist reguleerivatest normidest. Artikli aluseks on Riigikohtus 2010. aasta sügisel koostatud kohtupraktika analüüs

  19. 8 . TOTAL THRUST ON EARTH-RETAlNING STRUCTURES DUE ...

    African Journals Online (AJOL)

    The various surcharges along retaining walls may include vehicle loads ... be developed from ice formation due to pore water freezing. ... Figure 1 Lateral pressure against rigid wall due to ... value for the case of a line load is due to the effect.

  20. Viktor Misiano kureerib Mark Raidperet ning Jaan Toomikut

    Index Scriptorium Estoniae

    2007-01-01

    27.05-26.08.2007 esitatakse Itaalia kunstikeskuses Pratos näitusel "Progressive Nostalgia" Jaan Toomiku videot "Merikajakas" (2004) ja Mark Raidpere videot "Andrei/Andris" (2006). Loetletud osalejad teistest maadest

  1. Banaanikasvatuse alused ning tootmispõhine teadus / Andres Taklaja

    Index Scriptorium Estoniae

    Taklaja, Andres, 1947-

    2011-01-01

    Kõrgtehnoloogilise tootmise ja tugevate ülikoolide seosest Silicon Valley näite põhjal ehk teaduspõhisest tootmisest ja tootmispõhisest teadusest, kus suured ettevõtted on tähtsad teaduse tellijad

  2. Puhtus ja kord majas ning mõtetes / Ene Vool

    Index Scriptorium Estoniae

    Vool, Ene, 1948-

    2007-01-01

    Kalle Rõõmuse projekteeritud inimese bioenergiast lähtuvast eramust, kus raudse järjekindlusega kasutati energeetilisest seisukohast ülimalt inimsõbralikke loodusmaterjale - mida vähem materjale, seda vähem väljamõjusid. Sisearhitekt oli Terje Kivist. Kalle Rõõmuse kommentaar

  3. 75 FR 337 - Action Affecting Export Privileges: Ning Wen

    Science.gov (United States)

    2010-01-05

    ... electronic components from the United States to the People's Republic of China (PRC) in violation of U.S... security reasons and their export to the PRC requires a license from the U.S. Department of Commerce... Shipper's Export Declarations, which are filed with the U.S. Government and which must contain information...

  4. Loe raha, ole paindlik ning kuula klienti / Peep Ehasalu

    Index Scriptorium Estoniae

    Ehasalu, Peep, 1966-

    2004-01-01

    Eesti ettevõtete TOP 100 1. koht. Kolmandat aastat järjest edetabeli tippu jõudnud Tele2 edu rajaneb kolmel sambal. Lisad: Tele2 Eesti AS; Tele2 pürgib maruliselt kõrgustesse. Kommenteerivad Andrus Hiiepuu, Inna Kramer ja Agne Kivisaar.

  5. Euroopa Majandus- ja Rahaliit ning rahapoliitika maailma kolmes peamises valuutaregioonis

    Index Scriptorium Estoniae

    2002-01-01

    Ilmunud ka: Alternative exchange rate regimes in the globalised world : conference dedicated to the 10th anniversary of the re-introduction of the Estonian kroon. - Tallinn. Vestlusringis esinesid Euroopa Keskpanga esindaja Pierre Vander Haegen, Saksa Liidupanga asepresident Jürgen Stark, Keio ülikooli professor Eisuke Sakakibara, USA rahandusministeeriumi atashee Euroopas James G. Wallar

  6. Application of direct current electrical technique in the prevention and control of water in Tang mouth coal company%直流电法技术在唐口煤业公司煤矿防治水方面的应用

    Institute of Scientific and Technical Information of China (English)

    蔺成森

    2016-01-01

    该文简要介绍了井下直流电法技术在唐口煤业公司煤矿防治水几个方面的应用,如探测工作面顶底板砂岩和底板三灰的富水性、工作面内是否发育隐伏断层以及工作面是否发育陷落柱、巷道掘进迎头前方导水断层的含(导)水性、评价工作面回采时的水害安全性等,同时对直流电法的特点和在应用中需注意的问题进行归纳。%This paper briefly introduces the application of mine DC electrical method in the Tang mouth coal company coal mine water prevention and control several aspects, such as detection of working face roof floor sandstone and the bottom three ash rich water, the development of buried fault and the development of subsided column in the working face, the aquosity of the fault with water permeability in the front of tunneling, the evaluation of the flood safety during mining, at the same time inducted the DC electrical characteristics and problems needing attention in the application.

  7. Eesti Vaegkuuljate Liit kostmas vaegkuuljate huvide eest / Pear Tang

    Index Scriptorium Estoniae

    Tang, Pear

    2010-01-01

    Eesti Vaegkuuljate Liidu eestkostetegevuse aktiviseerimisest ja projektist "Eesti vaegkuuljate katusorganisatsiooni eestkoste võimekuse tõstmine", millega mõõdeti organisatsiooni eestkostevõimekust

  8. The analysis of Stability reliability of Qian Tang River seawall

    Science.gov (United States)

    Wu, Xue-Xiong

    2017-11-01

    Qiantang River seawall due to high water soaking pond by foreshore scour, encountered during the low tide prone slope overall instability. Considering the seawall beach scour in front of random change, using the simplified Bishop method, combined with the variability of soil mechanics parameters, calculation and analysis of Qiantang River Xiasha seawall segments of the overall stability.

  9. From Early Tang Court Debates to China's Peaceful Rise

    NARCIS (Netherlands)

    2009-01-01

    Dit boek biedt een verfrissende kijk op 1400 jaar Chinese geschiedenis. In acht artikelen worden politieke, religieuze, maatschappelijke economische en culturele geschiedenis tegen het licht gehouden. Uiteenlopende ontwikkelingen komen aan bod, van de interreligieuze rechtbankdebatten van de

  10. Potagers domestiques et étangs de pisciculture, sources de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    État du Kerala, on trouve plusieurs variétés d'igname et de riz. Toutefois, on constate une érosion de cette diversité au profit de grandes cultures commerciales et industrielles dans les trois districts, qui sont maintenant considérés comme des ...

  11. Peer To Peer-utlåning i Sverige : En komparativ studie mellan bankutlåning och Peer To Peer-utlåning på den svenska konsumentkreditmarknaden

    OpenAIRE

    Edman, Lars; Kaltea, Kristofer

    2015-01-01

    Background: Peer to peer lending has in recent years emerged and become a popular way to borrow money, mostly in the US and the UK. Since the first company was established in 2005, several competitors have emerged, and P2P lending has grown on average by 84 % quarterly between the second quarter year 2007 and the second quarter year 2014 in the US. Lending Club, which is the largest player within P2P-lending, has since its start in 2008 carried loans of a total value of six billions USD. Aim:...

  12. Forskningstræning i speciallægeuddannelsen i anæstesiologi

    DEFF Research Database (Denmark)

    Afzali, Monika; Jansen, Tejs; Skjelsager, Karen

    2014-01-01

    This article describes the structure of the research training module, as a part of the education programme for anaesthesiologists in the eastern region of Denmark. The module consists of courses, independent work on a project, guidance and evaluation. In a period of about four years a total of 56...... anaesthesiologists have completed the programme. A questionnaire revealed that 59% felt their abilities to read and interpret research had been improved and 30% reported an increasing interest in research. 40% had presented their project at scientific meetings and 25% had published their project....

  13. Väärt vara linnas ning maal / Ain Alvela ; kommenteerinud Mart Saa

    Index Scriptorium Estoniae

    Alvela, Ain, 1967-

    2010-01-01

    Uus Maa Kinnisvarabüroo tegevjuhi Mika Sucksdorffi hinnangul on Tallinnas kinnisvara üks arengusuundi Kalamaja-Kopli-Paljassaare piirkond. A&A Kinnisvara tegevjuhi Aivar Villemsoni hinnangul hakkavad kinnisvarahinnad tõusma esmalt pealinna keskmes, Rocca al Mare ja Pirita kandis

  14. Forskningstræning er utilstrækkeligblandt kommende læger

    DEFF Research Database (Denmark)

    Binderup, Marie Louise Mølgaard; Ete, Neval Ete; Ovesen, Christian

    2012-01-01

    This questionnaire survey investigated interest and activity in pregraduate research among 643 medical students at the Faculty of Health and Medical Sciences at the University of Copenhagen. We find, that although the students show great interest and motivation for research, very few have actual ...... research experience. The students described suboptimal research training, lack of tutoring and facilitation as well as of career counselling. Also, conditions for pregraduate research activities are unequal among the faculties of health sciences in Denmark....

  15. Film, ruum ja narratiiv : "Mis juhtus Andres Lapeteusega?" ning "Viini postmark" / Eva Näripea

    Index Scriptorium Estoniae

    Näripea, Eva, 1980-

    2011-01-01

    Analüüsitakse narratiivi aegruumi loomise viise juhtumi analüüsi vormis, vaadeldes kaht eesti mängufilmi : G. Kromanovi "Mis juhtus Andres Lapeteusega?" (Tallinnfilm, 1966) ja Veljo Käsperi "Viini postmark" (Tallinnfilm, 1967)

  16. Film, ruum ja narratiiv : "Mis juhtus Andres Lapeteusega?" ning "Viini postmark" / Eva Näripea

    Index Scriptorium Estoniae

    Näripea, Eva

    2006-01-01

    Analüüsitakse narratiivi aegruumi loomise viise juhtumi analüüsi vormis, vaadeldes kaht eesti mängufilmi : G. Kromanovi "Mis juhtus Andres Lapeteusega?" (Tallinnfilm, 1966) ja Veljo Käsperi "Viini postmark" (Tallinnfilm, 1967)

  17. Process Writing and the Internet: Blogs and Ning Networks in the Classroom

    Science.gov (United States)

    Boas, Isabela Villas

    2011-01-01

    In contrast to the product approach to writing, which is based on studying and replicating textual models, the process approach involves multiple and repeated steps that compel the writer to closely consider the topic, language, purpose for writing, and social reality of an audience. In addition to discussing the benefits of the process approach…

  18. Punase koolimaja saamisloost ning ajast enne ja pärast seda / Aavo Soopa

    Index Scriptorium Estoniae

    Soopa, Aavo

    1998-01-01

    Viljandi Maagümnaasiumi 120. aastapäeval meenutatakse G.M. Schmidti eraõppeasutust ja selle järglase Liivimaa Maagümnaasiumi sündi ja tegevust : ka Riia arhitekti R. Häuseri projekteeritud kahekorruselisest punasest tellismajast, mis valmis 1877.a.

  19. Filosofisk terapi som træning til døden

    DEFF Research Database (Denmark)

    Dræby, Anders

    Den eksistentielfænomenologiske terapi deler den opfattelse med stoicismen, at filosofiens hovedopgave er at hjælpe mennesket med at finde vej i en problematisk verden. Oplægget udforsker desuden et overlap, som består i den indsigt, at terapeutisk udfrielse fra menneskelig lidelse til livsduelig......Den eksistentielfænomenologiske terapi deler den opfattelse med stoicismen, at filosofiens hovedopgave er at hjælpe mennesket med at finde vej i en problematisk verden. Oplægget udforsker desuden et overlap, som består i den indsigt, at terapeutisk udfrielse fra menneskelig lidelse til...

  20. Ülevaade peamistest majandusindikaatoritest 1993-2000. a. ning prognoos 2001. a.

    Index Scriptorium Estoniae

    2001-01-01

    Sisemajanduse koguprodukt, tarbijahinna indeks, väliskaubandus, tööhõive, tööstustoodang, elanike sissetulekud, jae-ettevõtete kaubakäive. Diagrammid ja tabel: tähtsamad majandusindikaatorid ja nende prognoos 2001.a. Järgneb: Konjunktuur, juuni, nr. 2, 2001, lk. 36-38. Ilmunud ka: Konjunktuur : Quarterly Review of the Estonian Economy, mai, nr. 1, 2001, lk. 43-45; juuli, nr. 2, 2001, lk. 34-36

  1. Kollektiivse esindamise organisatsioonide litsentsitasud: suurusele seatud nõuded ning nende rakendamine / Mari Haamer

    Index Scriptorium Estoniae

    Haamer, Mari, 1993-

    2016-01-01

    Kollektiivse esindamise organisatsioonidest ja nende funktsioonist. Kollektiivse esindamise organisatsioonide litsentsitasude suurusest Eesti õiguses, nende nõuete täitmise kontrollimisest. Kasutajate ja kollektiivse esindamise organisatsioonide huvide tasakaalu säilitamisest. Sisaldab asjakohast kohtupraktikat

  2. Kulikov : Vene kinnisvaraäris toob edu enesekindlus ning lai silmaring / Krister Paris

    Index Scriptorium Estoniae

    Paris, Krister, 1977-

    2004-01-01

    Vene kinnisvaraärimehest Jevgeni Kulikovist, kes on Eestis toimuval rahvusvahelisel konverentsil "Kinnisvara 2004" peaesineja. Lisad: Kompanii MIEL; Vene kinnisvaraturg; Grigori Kulikov - Vene hinnatuim

  3. 1,65 miljardi dollari eest edevust ning näpatud saateid / Kalle Kose

    Index Scriptorium Estoniae

    Kose, Kalle

    2006-01-01

    Interneti sotsiaalvõrgustikust YouTube ja selle liitumisest Google'iga. Vt. ka: Intervjuu kasutajaga : "YouTube'i pärast on jäänud nii mõndagi tegemata." Aktsiakaupleja Oliver Peek räägib YouTube'i kasutamisest teleri asendajana. Diagramm: Videovahetuse keskkondade turuosad. Graafik: Videovahetuskeskkondade turuosa kasv USA-s

  4. Hjemmetræning på tværs af sektorer betaler sig

    DEFF Research Database (Denmark)

    Larsen, Torben

    2009-01-01

    plejeforanstaltninger og en afkortet liggetid på sygehuset. Udover sundhedsmæssige gevinster er der et samfundsøkonomisk besparelsespotentiale, som er betinget af en overvindelse af organisatoriske, finansielle og faglige barrierer jf. SWOT-analysen.    Da problemerne med at implementere denne viden i sundhedsvæsenet...

  5. Juhtimissüsteemide selgroog. Lean ning ISO - terviklahendused tootmise haldamiseks / Anton Ovsjankin

    Index Scriptorium Estoniae

    Ovsjankin, Anton

    2011-01-01

    Kasvanud on juurutatavate Lean ja ISO süsteemide arv, kuid on kasvanud ka nende juurutamise ja arendamisega seotud ebaõnnestumiste arv. Põhjustest, miks jäävad paljud Leani ja ISO juurutanud ettevõtted ilma lubatud tulemusteta. Leani ja ISO haldamiseks vajalikest teguritest

  6. Molecular Scree ning of Blast Resistance Genes in Rice Germplasms Resistant to Magnaporthe oryzae

    Directory of Open Access Journals (Sweden)

    Liang Yan

    2017-01-01

    Full Text Available Molecular screening of major rice blast resistance genes was determined with molecular markers, which showed close-set linkage to 11 major rice blast resistance genes (Pi-d2, Pi-z, Piz-t, Pi-9, Pi-36, Pi-37, Pi5, Pi-b, Pik-p, Pik-h and Pi-ta2, in a collection of 32 accessions resistant to Magnaporthe oryzae. Out of the 32 accessions, the Pi-d2 and Pi-z appeared to be omnipresent and gave positive express. As the second dominant, Pi-b and Piz-t gene frequencies were 96.9% and 87.5%. And Pik-h and Pik-p gene frequencies were 43.8% and 28.1%, respectively. The molecular marker linkage to Pi-ta2 produced positive bands in eleven accessions, while the molecular marker linkage to Pi-36 and Pi-37 in only three and four accessions, respectively. The natural field evaluation analysis showed that 30 of the 32 accessions were resistant, one was moderately resistant and one was susceptible. Infection types were negatively correlated with the genotype scores of Pi-9, Pi5, Pi-b, Pi-ta2 and Pik-p, although the correlation coefficients were very little. These results are useful in identification and incorporation of functional resistance genes from these germplasms into elite cultivars through marker-assisted selection for improved blast resistance in China and worldwide.

  7. Balansseerimine abstraktse liikumise ning tähendusliku loo vahel / Evelin Lagle

    Index Scriptorium Estoniae

    Lagle, Evelin

    2008-01-01

    "Augusti tantsufestival" Tallinnas Kanuti gildi saalis 21.-31. VIII 2008. Tantsulavastustest "Gallina Aquatica", "Creating Sense", "Mi madre y yo", "Ball", "Radiodance", "And I just stood there watching the sky and the people below"

  8. Effekten av fysisk träning på e-sportprestation

    OpenAIRE

    Johnsson, Oliver

    2017-01-01

    Purpose The purpose of this study was to investigate the effects of physical exercise on different skills that affect e-sports performance for e-sportsmen at amateur level in the game Overwatch. This is to gain knowledge about how e-sports training could be developed and streamlined. Methods The study is of the explorative research type since it deals with a topic that haven’t previously been broadly investigated. The method used was a quantitative exploratory method. The design was an inte...

  9. Kardial adaptation til fysisk træning--fysiologiske og kliniske aspekter

    DEFF Research Database (Denmark)

    Gustafsson, F; Mehlsen, J

    1999-01-01

    Vigorous physical training induces left ventricular hypertrophy (LVH), a so-called "athlete's heart". The hypertrophic response represents an adaptation to the increased haemodynamic load on the heart associated with physical exercise. Wall thickness and/or left ventricular internal diameters...... these athletes are male oarsmen. Occasionally, it may be difficult to distinguish physiological LVH from primary heart disease and therefore it is of importance also for physicians to be familiar with the "athlete's heart". Also, the sensitivity of the non-invasive methods for detecting coronary heart disease...

  10. Võimalusi ning viiteid teatrikunsti ja muinasjutu sobitamisele teatriõhtuks / Rait Avestik

    Index Scriptorium Estoniae

    Avestik, Rait

    2006-01-01

    Muinasjuttudest (nende teatralisatsioonidest) täiskasvanutele Eesti teatris - "Jänese aasta" (Von Krahli Teater, lav. Kristian Smeds), "Suur kuri hunt" (Vanemuine, lav. Taago Tubin), "Kaks päikest" (NO99, lav. Andres Noormets), "Troll-Poiss" (Eesti Riiklik Nukuteater, lav. Finn Poulsen)

  11. Velfungerende forskningstræning i gynækologi og obstetrik

    DEFF Research Database (Denmark)

    Settnes, Annette; Lykkebo, Annemette Windfang; Eriksen, Gitte

    2011-01-01

    In 2003 The National Board of Health, Denmark, enforced a compulsory training course in academic research as part of the specialist training for doctors. The trainees must learn to search and evaluate relevant literature and be able to implement the results in clinical practice. The structure of ...

  12. Development and Evaluation of Ning Social Network for Teaching Training Online Surveillance

    Science.gov (United States)

    Mohd Nawi, Mohd Aliff; Jamsari, Ezad Azraai; Sulaiman, Adibah; Hamzah, Mohd Isa

    2013-01-01

    Supervision of teaching practice is an important aspect of training teachers in improving their teaching skills. Barriers such as distance and time factor are the constraints faced by the lecturers at the National University of Malaysia to communicate with the teacher trainees under their supervision. Therefore, this study aims to develop and…

  13. Haldusleping : mõiste, kasutusala ning mõned olulised õiguslikud jooned / Martin Hirvoja

    Index Scriptorium Estoniae

    Hirvoja, Martin, 1977-

    1999-01-01

    Halduslepingu mõistest ja piiritlemisest teistest avalik-õiguslikest ja eraõiguslikest lepingutest, halduslepingu kasutusalast, kirjalikust vormist, motiveerimisest, tühisusest ja tühistatavusest

  14. Tartu ja Tallinna boheemkond ning lotovõitjad : Valitud palu dokumentaalfilmide sarjast "Eesti lood" / Olev Remsu

    Index Scriptorium Estoniae

    Remsu, Olev, 1947-

    2009-01-01

    ETVs näidatud dokumentaalfilmidest sarjas "Eesti lood" - Indrek Kangro film Jaan-Jürgen Klausist "Professionaalne amatöör" (eetris 3. XII 2008), Margit Lillaku film kunstnik Sandra Jõgevast "Ars longa" (eetris 29. X 2008), Eva-Katariina Taimre "Jackpot" lotovõitjatest (eetris 19. XI 2008)

  15. "Popi ja Huhuu" ning tema eelkäija eesti kirjanduses / Pille-Riin Larm

    Index Scriptorium Estoniae

    Larm, Pille-Riin, 1981-

    2012-01-01

    Friedebert Tuglase novelli "Popi ja Huhuu" kõrvutatakse 1881. aasta Meelejahutajas ilmunud anonüümse ajaviitejutuga "Ahvi armastus ja kättemaksmine". - Jutuke "Ahwi armastus ja kättemaksmine" sisaldub artikli lisas lk. 750-754

  16. Kehakunsti valu ning võlu : kolm Manifesta performance'it / Harry Liivrand

    Index Scriptorium Estoniae

    Liivrand, Harry, 1961-

    1998-01-01

    Performance'id : New Yorgis elava poola kunstniku Piotr Uklanski 'Üleni põlemine', belgia kunstniku Honoré d'O 'Käsikiri varahoidjale', serblase Tanja Ostojici performance. Luksemburgi kunstniku Bert Theisi reis 'Dialektiline hüpe'

  17. Millestki ürgsest ja kargest ning autoriteediröövist / Madis Ernits

    Index Scriptorium Estoniae

    Ernits, Madis, 1971-

    2015-01-01

    Riigikorraldust reguleerivatest põhiseadusnormidest. Riigikohtu lahendist 3-4-1-6-12: õiguskantsleri taotlus nr 8 „Euroopa stabiilsusmehhanismi asutamislepingu artikkel 4 lõike 4 põhiseadusele vastavuse kohta.” Kriitika ja arvamused ESM-kaasuse kohta

  18. Järgsilpide "o" ja "u" varieerumine ning traditsioonid vanas kirjakeeles / Külli Prillop

    Index Scriptorium Estoniae

    Prillop, Külli

    2009-01-01

    Kirjeldatakse, mida võib vanade tekstide põhjal oletada "o" ja "u" vaheldumisest ja selle põhjustest, kasutades eelkõige Georg Mülleri jutluste tekste. Selgitatakse ka probleeme vana kirjakeele tekstide põhjal keelemuutuste kohta järelduste tegemisel

  19. Eile sai Eesti Kunstimuuseumi asutamisest 86 aastat ning Tartu Kunstimuuseumi asutamisest 65 aastat

    Index Scriptorium Estoniae

    2005-01-01

    Kumu ettekannetepäev "Roheline, toores ja lõikamata. Noor eesti kunst uue sajandi alguses" sarjast "Lisandusi eesti kunstiloole". Esinesid Karin Laansoo, Irit Rogoff, Kaido Ole, Kristjan Mändmaa, Rael Artel. Esitleti raamatut "22 + Noored eesti kunstnikud. Young Estonian Artists". 18. XI kirjutatakse alla Jaapani valitsuse kultuuritoetusleping, mis on suunatud Kumu varustamiseks kaasaegse audiogiidi süsteemiga, esitlustehnika ja maalikonserveerimislabori tehnikaga

  20. Assessment of absorption of four lignan constituents of JingNing ...

    African Journals Online (AJOL)

    Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria. All rights ... There are some methods used to evaluate intestinal absorption kinetics .... gravimetric correction method proposed by. Sutton et al was ...

  1. Træning af kontrolleret empati i accelererede kræftbehandlingsforløb

    DEFF Research Database (Denmark)

    Roelsgaard Obling, Anne

    2012-01-01

    This paper takes departure from sociology of emotions to explore the training of empathy and empathic response in accelerated cancer care. The paper focuses on a training workshop in empathic communication during which doctors from a cancer clinic learn to recognise and control the emotional frame...... of doctor-patient interactions. Through a descriptive analysis, it addresses how communication techniques are rehearsed and it discusses the effects of this training. It is shown that the performance of communicating empathically relies on standardised scripts, which direct and cultivate the conduct...... of techniques of micro-management such as qualitative measurement and performance audit. In other words, attempts to improve softer dimensions of medical services entail a further standardisation of these dimensions....

  2. Avaliação de Desempenho dos Aspectos Tangíveis e Intangíveis da Área de Mercado: estudo de caso em uma média empresa industrialPerformance Evaluation of Tangible and Intangible Aspects of the Market Area: a case study in a medium industrial companyEvaluación del Desempeño de los Aspectos Tangibles e Intangibles del Área de Mercado: un estudio de caso en una empresa industrial mediana

    Directory of Open Access Journals (Sweden)

    BORTOLUZZI, Sandro César

    2010-12-01

    Full Text Available RESUMOA pesquisa objetiva construir um modelo de Avaliação de Desempenho (AD para a área de mercado em uma média empresa industrial, por meio da Metodologia Multicritério de Apoio à Decisão Construtivista (MCDA-C. O estudo caracteriza-se como um estudo de caso, de natureza exploratória, e faz uso de entrevista e de análise de documentos internos como estratégia de coleta de dados. Como resultado, constatou-se que o modelo de AD construído para a área de mercado é composto por 08 indicadores financeiros (tangíveis e 39 indicadores não financeiros (intangíveis que respondem pelo desempenho da empresa. Adicionalmente, o artigo apresenta os seguintes resultados: (a identificação de três dimensões que respondem pelo desempenho da área de mercado: stakeholders, vendas e imagem; (b construção de escalas ordinais e cardinais para cada indicador do modelo; (c avaliação do status quo da área de mercado em 25 pontos, em uma escala onde 0 ponto equivale ao nível “neutro” e 100 pontos equivalem ao nível “bom”; e (d demonstração do processo de gerenciamento do desempenho. Conclui-se que o sistema de AD é importante para apoiar o desenvolvimento gerencial das pequenas e médias empresas (PMEs e que a Metodologia MCDA-C é um caminho viável para AD em um contexto complexo onde: (a o gestor desconhece as variáveis que devem ser avaliadas (tangíveis e intangíveis; (b existem particularidades nas PMEs que devem ser consideradas no modelo de AD.ABSTRACTThe work aims to build a model Performance Assessment (PA to the market area in an average industrial company through Multicriteria Decision Aid Constructivist (MCDA-C. The study is characterized as an exploratory case study and makes use of interviews and document analysis as a strategy for data collection. In the results section we present the performance evaluation model elaborated for the market area, where it was possible to identify eight financial indicators (tangible

  3. Investigation of tectonics and statistical analysis of earthquake hazard in Tange Sorkh dam

    OpenAIRE

    ZOLFAGHARI, Sayyed Yaghoub; RAFIEE, A.; HADI, S. M.R.; TAHERMANESH, R.

    2015-01-01

    Abstract. Today, most understood the importance of the risk of earthquakes with the intensification of the country's development, the rise in urbanization, the concentration of population and material and intellectual capital and increased vulnerability of the capital in the Iran seismic zone. Iran, as one of the most seismic countries in the world, in recent years has witnessed the devastating earthquake, for example can be pointed to earthquakes of Rudbar - Manjil, Bojnoord, Zir Kouh Ghaena...

  4. The therapeutic effect of modified Huangqi Guizhi Wuwu Tang for multiple myeloma

    OpenAIRE

    Tian, Mingmin; Huang, Huang

    2017-01-01

    Abstract Rationale: Multiple myeloma (MM) is a hematologic malignancy characterized by proliferation of clonal plasma cells in the bone marrow. The median survival has increased to 6 years in recent years. But MM remains incurable. Some studies about the effects of Chinese herb medicine on MM have been carried out. Long survival in MM patients through Traditional Chinese Medicine (TCM) therapies has been reported rarely before. Patient concerns: We report a case of a female patient who was di...

  5. Biogas from algae, seaweed and seagrass?; Biogas aus Algen, Tang und Seegras?

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, Holger [Fachhochschule Flensburg (Germany)

    2011-07-01

    Algae, seaweed and sea grass are discussed again and again as alternative sources for raw materials for agricultural biogas plants. The author of the contribution under consideration reports on the identification and optimization of the biogas potential of microalgae, macroalgae and flotsam (mixture of seaweed, seaweed, and so on). Algae, seaweed and sea grass can be fermented into biogas by means of an anaerobic process. The specific yield of biogas is small. The processing of these substrates requires a technical adjustment of the biogas plants. Thus, the effective use of these substrates will continue to fall. The achievable benefit highly depends on the location of the facilities and on the available substrates with the corresponding specific gas yields. The economic efficiency of these substrates in agricultural systems must be examined in each case.

  6. VizieR Online Data Catalog: Massive star forming molecular clumps Tkin (Tang+, 2017)

    Science.gov (United States)

    Tang, X. D.; Henkel, C.; Menten, K. M.; Zheng, X. W.; Esimbek, J.; Zhou, J. J.; Yeh, C. C.; Konig, C.; Yuan, Y.; He, Y. X.; Li, D. L.

    2016-10-01

    We have selected 30 massive clumps of the Galactic disk at various stages of high-mass star formation and with strong NH3 emission from the ATLASGAL survey (see Table 1). Our observations were carried out in 2015 April, July, and October with the 15m James Clerk Maxwell Telescope telescope (JCMT) on Mauna Kea. The beam size is ~23" and the main-beam efficiency is {eta}mb=Ta*/Tmb~=0.7 at 218GHz. The para-H2CO JKAKC =303-202, 322-221, and 321-220 transitions have rest frequencies of 218.222, 218.475, and 218.760GHz, respectively, which are measured simultaneously by employing the ACSIS digital autocorrelation spectrometer with the special backend configuration RxAH2CO250x3 allowing for three windows, each with a bandwidth of 250MHz. This provides a velocity resolution of 0.084km/s for para-H2CO (303-202 and 322-221) and 0.042km/s for para-H2CO (321-220); CH3OH (422-312) at 218.440GHz is also observed together with para-H2CO (322-221). (6 data files).

  7. IFSSH Flexor Tendon Committee report 2014: from the IFSSH Flexor Tendon Committee (Chairman: Jin Bo Tang).

    Science.gov (United States)

    Tang, Jin Bo; Chang, James; Elliot, David; Lalonde, Donald H; Sandow, Michael; Vögelin, Esther

    2014-01-01

    Hand surgeons continue to search for the best surgical flexor tendon repair and treatment of the tendon sheaths and pulleys, and they are attempting to establish postoperative regimens that fit diverse clinical needs. It is the purpose of this report to present the current views, methods, and suggestions of six senior hand surgeons from six different countries - all experienced in tendon repair and reconstruction. Although certainly there is common ground, the report presents provocative views and approaches. The report reflects an update in the views of the committee. We hope that it is helpful to surgeons and therapists in treating flexor tendon injuries.

  8. VizieR Online Data Catalog: ATLASGAL massive clumps H2CO data (Tang+,

    Science.gov (United States)

    Tang, X. D.; Henkel, C.; Wyrowski, F.; Giannetti, A.; Menten, K. M.; Csengeri, T.; Leurini, S.; Urquhart, J. S.; Koenig, C.; Guesten, R.; Lin, Y. X.; Zheng, X. W.; Esimbek, J.; Zhou, J. J.

    2017-11-01

    We selected the 110 brightest clumps from the ATLASGAL survey (the TOP100 sample) obeying simple IR criteria to cover a range in evolutionary stages as described in Giannetti et al. (2014, Cat. J/A+A/570/A65, Paper I) and Koenig et al. (2017, Cat. J/A+A/599/A139, Paper III). These clumps consist almost entirely of clumps that have the potential to form, or are forming, massive stars. Our observations were carried out on 2013 July and December, 2014 September and November, and 2015 April, June, July, and October with the Atacama Pathfinder EXperiment (APEX) 12m telescope located on Chajnantor (Chile). Five transitions of H2CO (J=3-2) were observed with the new MPIfR 1-mm receiver (PI230) with a beam size from 27.6" to 29.5" and integration times of 1 to 3 minutes. Five H2CO (J=4-3) transitions were observed with the FLASH receiver with a beam size ~21.4" and integration times of 2 to 4 minutes. (7 data files).

  9. Dual Regulating Effect of Shaoyao-Gangcao-Tang on COX- 2 ...

    African Journals Online (AJOL)

    through the differential regulation of cell adhesion molecules and chemokines expression [9]. These data indicate that 15d-PGJ2 can tightly regulate the resolution of acute inflammation. As the key enzyme of regulating PGE2 generation, COX-2 has been thought to be a pro- inflammatory mediator. However, Gilroy et al [10].

  10. Võrdseid võimalusi ja õppimist soodustav koolijuhtimine ning koolide autonoomia / Pavlos Hatzopoulos, Andreas Kollias, Kathy Kikis-Papadakis

    Index Scriptorium Estoniae

    Hatzopoulos, Pavlos

    2015-01-01

    Artikkel käsitleb European Policy Network on School Leadershipi (EPNoSL) raames tehtud analüüse, keskendudes kooli autonoomia küsimustele Euroopas, osutades vajadusele hoida kooli autonoomia ja keskvõimu otsustusõigus mõistlikus tasakaalus

  11. En tránsito a ningún lugar. Sobre Diario de una pasajera de Ágata Gligo

    Directory of Open Access Journals (Sweden)

    Alberto Giordano

    2014-06-01

    This essay presents a reading of Ágata Gligo’s Diario de una pasajera heedful to the ways in which her writing responds to the experiences of unhappiness and frustration related to the autobiographical circumstances that are in their origin: the disease (cancer and the literary block. The present workdiscusses how the act of understanding the disease and its social consequences reduce the diary’s writing performative power great thanksand how the distrust of the language dynamics and the novelist idealization obstruct the diary’s possibility of becoming a literary and existential immanent search.

  12. Astmelise tulumaksu mõju Eesti maksusüsteemile, kohalike omavalitsuste eelarvetele ning pensionireformile / Kairi Lainjärv

    Index Scriptorium Estoniae

    Lainjärv, Kairi

    2003-01-01

    Autor järeldab, et astmelise tulumaksu rakendamine vähendab kohalike omavalitsuste tulubaasi, lükkab edasi pensionireformi eesmärki suurendada kodumaist säästmist, rikub Eesti lubadust Euroopa Liidule säilitada proportsionaalne tulumaks, tekitab vajaduse suurendada tulubaasi säilitamiseks kaudsete maksude osakaalu, võib kaasa tuua majanduskasvu pidurdamise, suurendab jõukamate ja vaesemate ühiskonnakihtide võõrandumist üksteisest. Tabelid

  13. Peterburis pakutakse valgeid öid täis muusikat ning Neeme Järvit / Piret Tali

    Index Scriptorium Estoniae

    Tali, Piret, 1972-

    2005-01-01

    Peterburis toimuvast 7 nädalat kestvast süvamuusikafestivalist "Valgete ööde tähed/Stars of the White Nights", kontsertidel esinejatest. 25. juunil toimuvast Neeme, Paavo ja Kristjan Järvi ühiskontserdist

  14. Suur põgenemine 1944 : eestlaste lahkumine läände ning selle mõjud / Peep Pillak

    Index Scriptorium Estoniae

    Pillak, Peep, 1957-

    2005-01-01

    Välis-Eesti uuringute keskuse ja Rootsi Eesti saatkonna korraldatud teaduskonverensist (Tartu, 22. okt. 2004), kus arutluse all oli 1944. a. suur põgenemine läände ja selle mõjud tänasesse päeva

  15. "Vältimatud nuhtlused" : August Komendant, Louis I. Kahn ja arhitektuuri ning insenerikunsti keerulised suhted / Thomas Leslie

    Index Scriptorium Estoniae

    Leslie, Thomas

    2006-01-01

    Artikkel põhineb Thomas Leslie Kuressaares Louis Kahni päevadel peetud ettekandel. Louis Kahni koostöös August Komendandiga projekteeritud hoonetest pikemalt Richardsi Meditsiiniliste Uuringute laboratooriumist, Salki bioloogianistituudist (1959-1965, La Jolla, Kalifornia) ja Kimbelli kunstimuuseumist (1966-1972, Texas, Fort Worth). Bibl. lk. 75

  16. Fysisk træning hjælper også normalvægtige kvinder med polycystisk ovariesyndrom

    DEFF Research Database (Denmark)

    Bisgaard, Helene; Dela, Flemming

    2017-01-01

    Polycystic ovary syndrome (PCOS) affects 12-21% of women in the childbearing age and is the most common cause of hyperandrogenaemia and anovulatory infertility. There is an increase in insulin resistance in both overweight and lean women with PCOS. Exercise treatment is mandatory among...... the overweight women due to sufficient evidence that it can improve the signs and symptoms of PCOS. This has not been fully investigated among the lean. However, new randomized controlled trials show that structured physical exercise can also improve insulin sensitivity, hyperandrogenaemia and menstrual...... frequency in lean women with PCOS....

  17. Uudised : Ernesaksa auhind ning stipendiumid. Arvo Pärdi uus teos Roomas. Paavo Järvi Euroopas / Ilmar Moss

    Index Scriptorium Estoniae

    Moss, Ilmar

    2000-01-01

    4. dets. toimus Kuusalus G.Ernesaksa mälestuskontsert, kus anti üle stipendiumid ja Ernesaksa nim. auhind. 19. nov. toimus Roomas A.Pärdi teose "Cecilia, vergine romana" esiettekanne. P.Järvi kontsertidest detsembris Euroopas

  18. Direktiivsed kõneaktid ning nende kasutamise dünaamika isa ja ema kõnes: juhtumiuuring

    Directory of Open Access Journals (Sweden)

    Helen Kõrgesaar

    2015-04-01

    Full Text Available The aim of the article is to give an overview of directive speech acts in Estonian child-directed speech. Two school-age children from the same family and their dialogues with both parents individually are under observation. A longitudinal study has been used as the method (one child has been regularly recorded from ages 7 to 10, the other from ages 10 to 14, including 16 hours of audio material. All directive speech acts have been singled out from the parents’ speech and classified into imperatives, hints, prohibitions, statements of an addressee’s desired actions, permissions, speaker’s wishes, suggestions, hortatives, warnings and statements of social rules. Based on the analysis, comparisons are made between the mother’s and father’s speech with regard to the usage of different types of directives, and the dynamics of using directives when the child is growing as well as in situations of communication have been examined.

  19. Kunstinäituselt Jumala ja kanade juurde ning sealt põrgusse / Riin Kübarsepp

    Index Scriptorium Estoniae

    Kübarsepp, Riin, 1978-

    2005-01-01

    Mirja-Mari Smidti ja Allan Tõnissoo näitus "Kunstinäitus" Hobusepea galeriis 31. III-18. IV. Tanel Saare "Gott und Huhn episode IV: seed shower" kuni 23. IV Draakoni galeriis. Kuni 24. IV Tallinna Linnagaleriis Pirjetta Branderi näitus "Põrgu ja teised jutud", millega oli kaasas Mikko Tuhkaneni kunstniku loomingu analüüsi sisaldav kirjutis "A Woman's work is never done"

  20. Ældre patienter bør tilbydes fysisk træning tidligt efter kirurgi

    DEFF Research Database (Denmark)

    Beyer, Nina; Suetta, Charlotte Arneboe

    2013-01-01

    The use of fast-track regimes has led to a marked decline in complication rates post surgery. Nevertheless, older people have an increased risk of loss of muscle mass and strength and disability post surgery compared to younger adults. Consequently, attempts to counteract these problems seem highly...

  1. Euroopa ja Hiina pehme tasakaalustumine Ida-Aasia ning Ameerika Ühendriikide suhtes : arvustus / Jaanika Erne

    Index Scriptorium Estoniae

    Erne, Jaanika 1967-

    2013-01-01

    Arvustus: Nicola Casarini. Remaking Global Order: The Evolution of Europe-China Realtions and its Implications for East Asia and the United States. Oxford: Oxford University Press, 2010. (Oxford Scholarship Online.) 344 pp

  2. Detsibill : Meie aja kangelane Maryn E. Coote ning ajakirjandus. White label : Soda Effect - Uus kraam. Kuula / DJ Pickney Tiger

    Index Scriptorium Estoniae

    DJ Pickney Tiger, pseud., 1970-

    2007-01-01

    Poplauljast Marju Kuudist. Ansambli Soda Effect heliplaadist. Heliplaatidest: Sentenced "Buried Alive", Depeche Mode"Best of. Volume 1", Moby "Go: The Very Best", Bill Frisell, Ron CArter, Paul Motian "Nonesuch", My Chemical Romance "The Black Parade", Arabanda "Shams", Barbariz "Auh", Demogustico "Demogustico", Tutty Moreno ft. Jouce "Magica", Akon "Konvicted", Union Of Knives "Violence and Birdsong", Snoop Dogg "The Blue Carpet Treatment"

  3. Kommunikationsträning för personal kan öka patienters utbyte av vården

    DEFF Research Database (Denmark)

    Ehrstedt, Frida; Ammentorp, Jette; Kofoed, Poul-Erik

    2014-01-01

    This literature review presents results of research on communication skills training (CST) of medical staff and its effect on patients. The 27 studies identified by a search in PubMed and Cochrane databases showed considerable heterogeneity in interventions, methods and study length. Most studies...

  4. Bækkenbundstræning til gravide og barslende kvinder--en gennemgang af et Cochrane-review

    DEFF Research Database (Denmark)

    Brostrøm, Søren; Due, Ulla; Lose, Gunnar

    2010-01-01

    Urinary and anal incontinence are prevalent in pregnant and parturient women. Pelvic floor muscle training is frequently employed for prevention and treatment. A recent Cochrane review is discussed. Fifteen studies with a total of 6,181 women were included. Pregnant women without urinary...... incontinence experienced a reduction of the risk of developing urinary incontinence in later pregnancy or post partum. Peripartum patients with urinary and anal incontinence experienced a reduction of their symptoms following training....

  5. Bækkenbundstræning til gravide og barslende kvinder--en gennemgang af et Cochrane-review

    DEFF Research Database (Denmark)

    Brostrøm, Søren; Due, Ulla; Lose, G.

    2010-01-01

    Urinary and anal incontinence are prevalent in pregnant and parturient women. Pelvic floor muscle training is frequently employed for prevention and treatment. A recent Cochrane review is discussed. Fifteen studies with a total of 6,181 women were included. Pregnant women without urinary...... incontinence experienced a reduction of the risk of developing urinary incontinence in later pregnancy or post partum. Peripartum patients with urinary and anal incontinence experienced a reduction of their symptoms following training...

  6. Ældre patienter bør tilbydes fysisk træning tidligt efter kirurgi

    DEFF Research Database (Denmark)

    Beyer, Nina; Suetta, Charlotte Arneboe

    2013-01-01

    The use of fast-track regimes has led to a marked decline in complication rates post surgery. Nevertheless, older people have an increased risk of loss of muscle mass and strength and disability post surgery compared to younger adults. Consequently, attempts to counteract these problems seem highly...... relevant. The number of studies on the effect of perioperative training is still limited. However, there is increasing evidence that strength training commenced early post surgery is safe and effective in regard to restore muscle function in older patients going through acute or elective surgery....

  7. Visionäärid ning disaini hälli kiigutajad Charles ja Ray Eames / Katrin Kask

    Index Scriptorium Estoniae

    Kask, Katrin

    2007-01-01

    Ameerika disainiklassikute Charles (1907-1978) ja Ray Eamesi (1912-1988) disainitud toolidest. Nende oma majast Californias, mis koosneb tehases valmistatud teras-, vineer- ja klaasdetailidest. Filmidest "Ülevaade Metropolitanist" ja "Powers of Ten"

  8. 18. sajandi teise poole Šoti valgustusliku arhitektuuri ideedest, nende retseptsioonist Vene keisrikojas ning baltisaksa kultuuriruumis / Epi Tohvri

    Index Scriptorium Estoniae

    Tohvri, Epi, 1970-

    2006-01-01

    Arhitektide Robert Adami (1728-1792), Charles Cameroni (1745-1812) ja William Hastie (Vassili Geste 1755-1832) loomingust. Šoti valgustusajastu olulisemad arhitektuuriideed. Robert Adami mõju Eestis mõisaarhitektuuris

  9. Fysisk træning som behandling af nedsat funktionsevne hos svage, hjemmeboende 75+-årige

    DEFF Research Database (Denmark)

    Vad, Esther; Worm, Charlotte; Lauritsen, Jens

    2002-01-01

    The aim of this study was to establish the value of physical training as a treatment of reduced physical ability in frail, elderly patients living at home.......The aim of this study was to establish the value of physical training as a treatment of reduced physical ability in frail, elderly patients living at home....

  10. Videolectures og peer feedback i færdighedestræning på biomekanikstudiet på SDU

    DEFF Research Database (Denmark)

    Lauridsen, Henrik Hein; Nørgaard, Cita

    studerende - hvordan kan vi fremme feedback i vores undervisningsmodeller? oÅbne muligheden for at give både synkron og asynkron Feedback på studerendes træningssituationer i færdighedslaboratoriet. oOptimere muligheden for at studerende kan give peer Feedback på hinandens optagelser vedr. indøvelse af...

  11. S. DR. O. NoREL, /iei Ge&ening NV ...

    African Journals Online (AJOL)

    Test

    maal beskaamd, dikwels opgehef en getroos. Ek wys uit baie bladsye bv. op die ontleding van Jakob se gebed, Gen. 32 :9 vv. soos op bl. 92 vv. gegee, van Jesaja 63:14 — 64:12 op bl. 123 vv.; op die uit nemende verklaring van die Bybelse voorstelling van die ken van God, bl. 176 v.; op die treffende karakterisering van ...

  12. Annemarie Bauer, Katharina Gröning (Hg.: Gerechtigkeit, Geschlecht und demografischer Wandel. Frankfurt am Main: Mabuse-Verlag 2008

    Directory of Open Access Journals (Sweden)

    Margret Karsch

    2009-07-01

    Full Text Available Der Sammelband belegt einmal mehr, dass Fürsorgeleistungen für Kinder und Ältere überwiegend von Frauen übernommen werden. Diese können und wollen die unbezahlte und oft unsichtbare Arbeit aber nicht mehr leisten – auch eine Frage der Gerechtigkeit. Die Autor/-innen plädieren für eine politische Debatte, um diesen Missstand aufzuheben. Wie wollen wir im Alter leben, was sind uns Unterstützung und Pflege wert? Die Fragen gehen uns alle an und verlangen eine gesamtgesellschaftliche Lösung. Da in Zukunft mehr alte Menschen auf Unterstützung angewiesen sein werden, muss die Fürsorge dringend neu organisiert werden.The collected volume proves once more that it is primarily women who care for children and the elderly. These women no longer can nor want to do the unpaid and often invisible work. This is also a question of equality. The authors plead for political debate that would correct these grievances. How do we want to live as we grow older, what is support and care worth to us? The questions apply to us all and require a cross-societal solution. Because in the future more elderly people will be dependant on support, care has desperately to be reorganized.

  13. Alexander Theodor von Middendorffi tegevus Liivimaa põllumajanduse edendajana ning tema seosed eesti rahvusliku liikumisega / Erki Tammiksaar

    Index Scriptorium Estoniae

    Tammiksaar, Erki, 1969-

    2006-01-01

    Middendorffi tegevusest Peterburis Peterburi Vabamajanduse Seltsi presidendina ja II ülevenemaalise põllumajandusnäituse organiseerijana. Middendorffi agraarpoliitilistest veendumustest, tegevusest Liivimaa Üldkasulikus ja ja Ökonoomilises Sotsieteedis, Middendorffi osast Aleksandrikooli probleemi segapuntras. Kuukirjast Eesti Põllomees ja Middendorffi suhetest J. V. Jannseniga

  14. Kaks kanget: Forgotten Sunrise ning Tharaphitha enne ja nüüd / Anders Melts, Ants Lill ; intervjueerinud Mart Kalvet

    Index Scriptorium Estoniae

    Melts, Anders

    2009-01-01

    Küsimustele vastavad dark-elektro-bändi Forgotten Sunrise laulja Anders Melts ja pagan-metal-bändi Tharaphita laulja-kitarrist Ants Lill. Ansamblitest ja nende esimestest heliplaatidest, mis üllitati hiljuti uuesti plaadifirma Nailboard Records poolt: Tharaphita albumi "Raev" digipack-CD, millele on lisatud 1996. aastal ilmunud neljalooline demosalvestis "Kui varjud põlevad" ja Forgotten Sunrise demo "Behind The Abysmal Sky" (1993) ja minialbumi "Forever Sleeping Greystones" (1994) lood

  15. Gestos efêmeros e obras tangíveis: a trajetória de Antonio Manuel

    Directory of Open Access Journals (Sweden)

    Cynthia Marie Canejo

    2006-11-01

    Full Text Available Ainda que tributária do construtivismo brasileiro, a produção artística de Antonio Manuel se manteve única e, muitas vezes, radical. Este artigo examina as especificidades do trabalho do artista, principalmente a partir de suas semelhanças e diferenças com os postulados do neoconcretismo.Even though related to Brazilian constructivism, Antonio Manuel's artistic production has remained unique, and, sometimes, radical. This article examines the particularities of his work, mainly from the point of view of its relations to neoconcretism's postulates.

  16. VizieR Online Data Catalog: H2CO and CO in 4 molecular clouds (Tang+, 2013)

    Science.gov (United States)

    Tang, X. D.; Esimbek, J.; Zhou, J. J.; Wu, G.; Ji, W. G.; Okoh, D.

    2017-11-01

    From September 2010 to August 2011, we observed the H2CO lin H110α line, and the 6cm continuum with the Nanshan 25m radio telescope of Xinjiang Astronomical Observatory. >From 15 to 26 May 2011, the 12CO and 13CO observations of the four regions were carried out with the 13.7m millimeter wave telescope of Purple Mountain Observatory in Delingha. (4 data files).

  17. VizieR Online Data Catalog: Global properties of z=1~2 GMASS galaxies (Tang+, 2014)

    Science.gov (United States)

    Tang, Y.; Giavalisco, M.; Guo, Y.; Kurk, J.

    2017-04-01

    The sample of galaxies discussed here is extracted from the Galaxy Mass Assembly Spectroscopic Survey (GMASS) described by Kurk et al. (2013, J/A+A/549/A63), a program of spectroscopic observations of a mid-IR magnitude-limited (mAB of IRAC 4.510 hr for the blue masks and 20-30 hr for the red masks. (1 data file).

  18. VizieR Online Data Catalog: NGC 6802 dwarf cluster members and non-members (Tang+, 2017)

    Science.gov (United States)

    Tang, B.; Geisler, D.; Friel, E.; Villanova, S.; Smiljanic, R.; Casey, A. R.; Randich, S.; Magrini, L.; San, Roman I.; Munoz, C.; Cohen, R. E.; Mauro, F.; Bragaglia, A.; Donati, P.; Tautvaisiene, G.; Drazdauskas, A.; Zenoviene, R.; Snaith, O.; Sousa, S.; Adibekyan, V.; Costado, M. T.; Blanco-Cuaresma, S.; Jimenez-Esteban, F.; Carraro, G.; Zwitter, T.; Francois, P.; Jofre, P.; Sordo, R.; Gilmore, G.; Flaccomio, E.; Koposov, S.; Korn, A. J.; Lanzafame, A. C.; Pancino, E.; Bayo, A.; Damiani, F.; Franciosini, E.; Hourihane, A.; Lardo, C.; Lewis, J.; Monaco, L.; Morbidelli, L.; Prisinzano, L.; Sacco, G.; Worley, C. C.; Zaggia, S.

    2016-11-01

    The dwarf stars in NGC 6802 observed by GIRAFFE spectrograph are separated into four tables: 1. cluster members in the lower main sequence; 2. cluster members in the upper main sequence; 3. non-member dwarfs in the lower main sequence; 4. non-member dwarfs in the upper main sequence. The star coordinates, V band magnitude, V-I color, and radial velocity are given. (4 data files).

  19. A floristic study of Kuh-e Khom in Tang Shekan region of Arsanjan county in Fars province

    Directory of Open Access Journals (Sweden)

    Masumeh Zare

    2015-10-01

    Full Text Available A floristic study was done in Kuh-e Khom in east of Arsanjan county as part of the southern Zagros in Fars province. Altitude of the region is ranged from 1740 to 3270 m above sea level. The flora of the region with an emphasis on identifying habitats and the effect of altitude on vegetation were studied and sampling was done from 2010 to 2012. Totally, 440 plant specimens of vascular plant were collected which were belonging to 50 families, 198 genera and 287 species. The angiosperm plants were dominant and from them the dicot plants with 37 families, 167 genera and 246 species had the most diversity. The monocots plants with 9 families, 27 genera and 37 species were the second diversely group in the region. Gymnosperms and Pteridophyte each with two species had the lowest number of species. In respect to species richness, Asteraceae (43 species was the largest family and after that Breassicaceae (33 species, Poaceae (24 species, Fabaceae (24 species, Lamiaceae (22 species, Caryophyllaceae (19 species and Boraginaceae (13 species had the most species diversity. Half of species were therophyte and 68% of species were belonging to Irano-Turanian region.

  20. A Case Study in Design Thinking Applied Through Aviation Mission Support Tactical Advancements for the Next Generation (TANG)

    Science.gov (United States)

    2017-12-01

    world, there is some ambiguity when discussing the design of a product , and ambiguity driven by market competition focus on a product’s meanings...constrained interpretation of design . One such case is the Artemide manufacturing company based out of Milan, highly awarded and regarded within the...project was a new design strategy radically divergent from convention, differentiating the product from competing groups while developing new

  1. MRP, Generalplan Ost ning baltisakslaste Eestist ja Lätist väljarändamine (Poola arhiivide valguses) / Peeter Järvelaid

    Index Scriptorium Estoniae

    Järvelaid, Peeter, 1957-

    2009-01-01

    Üürnike Liit korraldas 22. sept. 2009 Rahvusraamatukogus omandireformialase konverentsi. Õigusajaloolase ettekanne varade tagastamisest, kahjude kompenseerimisest, baltisakslaste väljarändamisest, II maailmasõjast

  2. Eesti luule ja poeetika tagasivaates : vestlus Vincent B. Leitchiga / Vincent B Leitch ; küsitles [ja tõlkis ning eessõna:] Anne Lange

    Index Scriptorium Estoniae

    Leitch, Vincent B

    2002-01-01

    V. B. Leitch oli ilmumata jäänud koguteose "The poetry of Estonia: essays in comparative analysis" toimetaja. Kogumikus oleks ilmunud Yale'i ülikoolis peamiselt 1960. a-tel peetud ettekanded eesti luulest. Loengud korraldas Aleksis Rannit. V. B. Leitch meenutab ka Ants Orast, kes oli tema doktoritöö juhendaja Florida ülikoolis

  3. Partiklid jah, jaa ning jajaa naaberpaari järelliikmena müügiläbirääkimistes / Riina Kasterpalu

    Index Scriptorium Estoniae

    Kasterpalu, Riina

    2005-01-01

    Vastavate partiklite funktsionaalsetest ülesannetest, kasutamisest ja tähendustest müügivestlustes telefoni teel peetud müügiläbirääkimisi analüüsides. Järgneb: Keel ja Kirjandus, 2005, nr. 12

  4. Aktiivse eutanaasia moraalsusest ning legaliseerimise võimalikkusest : [bakalaureusetöö] / Andres Simson ; Tartu Ülikool, õigusteaduskond ; juhendaja: Jaan Sootak

    Index Scriptorium Estoniae

    Simson, Andres

    1999-01-01

    Ajalooline ülevaade, aktiivse eutanaasia mõiste, liigid, erinevate koolkondade suhtumine, moraalsuse poolt- ja vastuargumendid, Austraalia eutanaasiaseadused, USA seadusandlus.Vt. ka: Juridica (1999) nr. 7, lk. 342-347

  5. Süvendatud majandus- ja rahandusliidu rajamine: mõju põhiõiguste kaitsele ning põhiseaduse aluspõhimõtetele / Alexander Lott

    Index Scriptorium Estoniae

    Lott, Alexander, 1987-

    2013-01-01

    Euroopa Parlamendi ja nõukogu määruse ettepanekust ühtse solveerimismehhanismi ja pankade ühtse solveerimisfondi loomiseks. Kriisilahendusmehhanismi loomise ettepanekust süvendatud majandus- ja rahaliidu rajamise kontekstis, mõjust omandipõhiõiguse kaitsele ja määruse kooskõlast põhiseaduse aluspõhimõtetega

  6. The Optical Resolution of Chiral Tetrahedrone-type Clusters Contai- ning SCoFeM (M=Mo or W) Using High Performance Liquid Chromatography Chiral Stationary Phase

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Amylose tris (phenylcarbamate) chiral stationary phase (ATPC-CSP) was prepared and used for optical resolution of clusters 1 and 2. n-Hexane/2-propanol ( 99/1; v/v) were found to be the most suitable mobile phase on ATPC-CSP.

  7. Tööotsija töötuks tunnistamise ning töötu abiraha määramise ja maksmise ajutise juhendi kinnitamise kohta

    Index Scriptorium Estoniae

    1991-01-01

    Kehtib 1. aprillist 1991. Lisatud ajutine juhend: töö vahendamine tööotsijale, töötule, töötu abiraha määramine ja maksmine Lisatud: töötu abiraha arvutamine. Muudatus: RT I 1992 nr. 27 art. 362

  8. Dareios I kuninglikust titulatuurist Behistuni raidkirja näitel ning võimalikud Mesopotaamia mõjutused selles / Andreas Johandi, Vladimir Sazonov

    Index Scriptorium Estoniae

    Johandi, Andreas, 1983-

    2016-01-01

    Dareios I tiitlitest "kuningas", "suurkuningas", "Pärsia kuningas", "kuningate kuningas", "Babüloni kuningas", "kõikide maade kuningas". Dareios I tiitlid erinesid Kyros II ja Kambyses II tiitlitest, samas pärines nende kõigi ametlik titulatuur enamasti Mesopotaamiast

  9. Ralf Köning, el comic queer y otros ejemplos: de la identidad gay en la cultura de la diversidad sexual

    OpenAIRE

    Saxe, Facundo Nazareno

    2009-01-01

    A partir de los años ochenta se produce en las narrativas alemanas y españolas una tematización creciente de la identidad gay surgida durante los años setenta, en lo que se denomina el período post-Stonewall. Esta tematización confronta y, al mismo tiempo, explora las raíces de los grandes escritores homoeróticos de la primera mitad del siglo XX. A su vez, este tema gay que se consolida durante los ochenta y noventa, paulatinamente, se va proyectando a otros géneros diferentes ...

  10. Styrket færdighedstræning eller afsporende forstyrrelse? Digitalisering af undervisning i øvelseslaboratorier på professionsuddannelserne

    DEFF Research Database (Denmark)

    Eriksen, Kathrine; Nielsen, Marianne

    2014-01-01

    I arbejdet med tilegnelse af praktiske færdigheder i professionsuddannelser, er værdien af digitalisering omdiskuteret. Der hersker således uenighed om digitalisering blot medfører passiv iagttagelse af udførelsen af færdigheder, eller om digitalisering kan medvirke til at styrke de studerendes...

  11. Keiserlikud portreegaleriid : kujunemislugu ning osa poliitilises ja kunstielus = Russian Imperial Portrait Galleries - Their History and Role in Art and Politics / Jelizaveta Renne

    Index Scriptorium Estoniae

    Renne, Jelizaveta, 1951-

    2008-01-01

    Portreemaalide kollektsioneerimisest Venemaal 18. sajandil - era- ja keiserlike portreegaleriide loomisest, kogude komplekteerimisest, ajaloolisest tähtsusest ja saatusest. Çeşme paleest ja kogust, Marmorpalee pildigaleriist, Romanovite portreegaleriist

  12. Keisrikultus Rooma riigis Juliuste-Claudiuste ja 1. Flaviuste dünastia valitsusajal ning selle võimalikud kajastused algkristlikus kirjanduses / Jaan Lahe, Ergo Naab

    Index Scriptorium Estoniae

    Lahe, Jaan, 1971-

    2014-01-01

    Keisrikultuse tekkimisest. Keisrikultusest üksikute keisrite valitsusajal. Keisrikultuse pühadest, templitest, ohvritest ja preestritest. Keisrikultusest kui religioossest ja sotsiaalsest fenomenist. Keisrikultuse võimalikest kajastustest algkristlikus kirjanduses. Jeesuse ülendamismotiivist Pauluse autentsetes kirjades. Jeesuse ülendamisest ja viimsest vaenlasest. Jeesuse ülendamismotiivist Pauluse koolkonna kirjutistes. Ülendamismotiivist kirjas koloslastele. Jeesusele omistatud Kyrios-tiitli arengujoontest ja võimalikest kontrastidest keisrikultusega

  13. Euroopa Sotsiaalfondi vahendid Eesti noortekeskustes - kasutus, tulemused ja mõju noortekeskustele ning ühiskonnale / Heidi Paabort ; kommenteerinud Kerli Kõiv, Tiina Sinijärv, Aire Pruus

    Index Scriptorium Estoniae

    Paabort, Heidi

    2013-01-01

    ESFi programmide tulemusel toimunud muutusi noorsootöös kommenteerivad Rõuge vallavalitsuse noorsootöö spetsialist Kerli Kõiv, Keila ANK ja Keila Noortekeskuse juhataja Tiina Sinijärv ja Nursi noorsootöös osaleja Aire Pruus

  14. Väike- ja keskettevõtete osakaalust majanduses ning ettevõtluspoliitika rollist ettevõtlusalase aktiivsuse toetamisel / Juhan Teder

    Index Scriptorium Estoniae

    Teder, Juhan, 1960-

    2004-01-01

    Ettevõtete struktuurist suurusgrupiti eri riikides; teguritest, mis nimetatud struktuuri mõjutavad; riikliku ettevõtluspoliitika rollist; soovitusi ettevõtlusalase aktiivsuse stimuleerimiseks. Tabelid

  15. Privaatsuse kaitse tagamine Eestis, Euroopa Liidus ning Ameerika Ühendriikides : [bakalaureusetöö] / Bert Blös ; Akadeemia Nord, õigusteaduskond ; juhendaja: Mailis Rand

    Index Scriptorium Estoniae

    Blös, Bert

    2002-01-01

    Privaatsuse kaitse avalikus sektoris, põhiseaduslikud alused, põhiõigused ja -vabadused, seadusandlus, riigiasutuste andmekogude regulatsioon Eestis, privaatsuse kaitse erasektoris, EL andmekaitse direktiiv, privaatsuse kaitse, probleemistik andmete edastamisel teistesse riikidesse

  16. Lotte ning ta sõbrad ja sugulased ehk Kas vägivallatus võib olla põnev / Leelo Tungal

    Index Scriptorium Estoniae

    Tungal, Leelo, 1947-

    2001-01-01

    Joonisfilmid "Lotte" ja "Lotte reis lõunamaale" : stsenaristid Andrus Kivirähk, Janno Põldma, Heiki Ernits : kunstnik Heiki Ernits : lavastajad Leo Lätti, Ebe Tramberg : helilooja Olav Ehala : Eesti Joonisfilm 2000. Lisa : S. Teinemaa koostatud J. Põldma ja H. Ernitsa filmograafia

  17. Teadus- ja arendustegevus ning kaalutlusõiguse roll selle rahastamisel : [teadusmagistritöö] / Sille Uusna ; Tartu Ülikool, õigusteaduskond ; juhendaja: Raul Narits

    Index Scriptorium Estoniae

    Uusna, Sille

    2007-01-01

    Teadus- ja arendustegevuse olemusest, teaduskorraldus objektiivse õiguse reguleerimise objektina, teaduspoliitika kujundamise meetoditest, haldusorgani kaalutlusõigus teaduskorralduses, teadus- ja arendustegevuse finantseerimine, kaalutlusõiguse osakaal teaduse finantseerimismeetmetes

  18. Eesti Panga staatus ning selle muutumine seoses euro kasutuselevõtuga : [bakalaureusetöö] / Ursula Laido ; Tartu Ülikooli Õigusinstituut ; juhendaja: Madis Kallion

    Index Scriptorium Estoniae

    Laido, Ursula

    2005-01-01

    Eesti Panga ajalugu, õiguslik staatus, juhtimine, ülesanded, pädevus, Euroopa Liit kui Euroopa Majandus- ja Rahaliit, keskpankade süsteem, euro, eurole üleminek ja sellest tulenevad muudatused Eesti Panga jaoks

  19. Lapsendamise sotsiaalsed ning psühholoogilised aspektid Eesti ja Soome võrdluses : [magistritöö] / Kalmer Puusepp ; Tartu Ülikool, õigusteaduskond ; juhendaja: Silvia Kaugia

    Index Scriptorium Estoniae

    Puusepp, Kalmer, 1972-

    2013-01-01

    Lapsendamise mõiste ajaloolisest arengust Eesti ja Soome õiguskorras, abikaasade õiguslikust regulatsioonist lapsendamisel Eestis ja Soomes, lapsendamise peamistest sotsiaalsetest aspektidest Eestis ja Soomes, lapsendamise psühholoogilistest aspektidest, Tartu Maavalitsuse ja Helsingi linna sotsiaal - ja tervise ameti arvamustested

  20. Bu-Shen-Ning-Xin Decoction ameliorated the osteoporotic phenotype of ovariectomized mice without affecting the serum estrogen concentration or uterus

    OpenAIRE

    Wang, Ling; Qiu,Xue-Min; Gui,Yu-Yan; Xu,Yingping; Gober,Hans-Jürgen; Li,Da-Jin

    2015-01-01

    Ling Wang,1,2,* Xue-Min Qiu,1,2,* Yu-Yan Gui,1,2 Ying-Ping Xu,1,2 Hans-Jürgen Gober,3 Da-Jin Li1 1Laboratory for Reproductive Immunology, Hospital and Institute of Obstetrics and Gynecology, IBS, Fudan University Shanghai Medical College, 2Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, People’s Republic of China; 3Department of Pharmacy, Wagner Jauregg Hospital and Children’s Hospital, Linz, Austria *These authors contribute...

  1. Rezension zu: Hildegard Maria Nickel, Andreas Heilmann, Hasko Hüning, Max Lill: Geschlechterpolitik in Krisenzeiten. Eine Fallstudie im Bankensektor. Berlin: edition sigma 2015.

    Directory of Open Access Journals (Sweden)

    Annett Schulze

    2015-12-01

    Full Text Available Am Beispiel der LandesBank Berlin zeigen die Autor/-innen konkrete Auswirkungen der Bankenkrise auf in Unternehmen agierende betriebliche Akteur/-innen. Inwiefern diese eigene Handlungsspielräume entwickeln (können und welche Kontinuitäten betriebliche Vergeschlechtlichungsprozesse aufweisen, belegt die Studie eindrücklich. Der mit dem Wandel von Erwerbsarbeit verknüpfte Eigensinn zeigt sich in den Vorstellungen von Zuständigkeiten der weiblichen Angestellten und in den veränderten Antworten auf Work-Life-Balance-Fragen ─ bei jungen männlichen Angestellten und bei älteren Führungskräften, die jungen Vätern einen Mentalitätswandel unterstellen. So könnten sich neue Kollektivierungen jenseits von Geschlecht bilden, insofern an geteilte Interessen in Krisensituationen angeknüpft werden würde.

  2. Træning har positiv effekt på helbredsrelateret livskvalitet hos kræftpatienter i behandling--en gennemgang af et Cochranereview

    DEFF Research Database (Denmark)

    Lønkvist, Camilla Kjær; Højman, Pernille; Gehl, Julie

    2013-01-01

    Cancer and treatment of cancer affects the health-related quality of life (HRQoL) in patients. A recent Cochrane review concludes that exercise may have positive effects on HRQoL and several other domains. Other reviews have shown that physical activity may protect against development of cancer...

  3. Kinnipeetud välismaa laevade ja laevaperede viivitamatu vabastamine - rannikuriigi kohustus ning lipuriigi võimalus diplomaatilise kaitse osutamiseks / Heiki Lindpere

    Index Scriptorium Estoniae

    Lindpere, Heiki, 1949-

    2007-01-01

    Ülevaade Ühinenud Rahvaste Organisatsiooni (ÜRO) 1982. aasta mereõiguse konventsioonis olevast reederite ja meremeeste huvide kaitseks kokkulepitud iseseisvast menetlusest Rahvusvahelises Mereõiguse Kohtus ja mujal

  4. [Valitsusliidus olevad Reformierakond ning Isamaa ja Res Publica Liit on kavandatava koolireformi suhtes eri meelt] / Mailis Reps, Tiiu Kuurme, Karin Kütt

    Index Scriptorium Estoniae

    Reps, Mailis, 1975-

    2010-01-01

    Reformierakonna ettepaneku kohta jätta omavalitsustele õiguse otsustada, kas gümnaasium ja põhikool lahutatakse või jätkatakse ühendkooliga avaldavad arvamust riigikogu liige Mailis Reps, Tallinna Ülikooli dotsent Tiiu Kuurme ja Rannu keskkooli direktor Karin Kütt

  5. Tahtluse vormid ning nende eristamine teoorias ja praktikas : [bakalaureusetöö] / Mattias Jõgi ; Tartu Ülikool, õigusteaduskond ; juhendaja: Anneli Soo

    Index Scriptorium Estoniae

    Jõgi, Mattias

    2010-01-01

    Tahtlusest Ameerika Ühendriikides ja mandri-Euroopas, tahtluse vormidest Eestis 1935. a. kriminaalseadustiku ja 1961. a. kriminaalkoodeksi järgi, tahtluse vormide eristamisest ja esinemisest kehtivas karistusseadustikus, kelmusest ja selle erikoosseisudest, kohtuotsustes tahtluse vormide eristamisest

  6. Athena konverentsi- ja kultuurikeskuse ning restorani Volga sisekujundus (Athena kinohoone renoveerimine). Tartu. Küütri 1 / Aivar Roosaar, Ferdi Sannamees, Peet Aren

    Index Scriptorium Estoniae

    Roosaar, Aivar

    2008-01-01

    I-III korruse, vahekorruse ja pööningu plaan, värv. välisvaade, 15 sisevaadet; fotod: Velvet Stuudiod; restaureeriti ka muinsuskaitse alla kuuluvad Ferdi Sannamehe neoklassitsistlikud stukkreljeefid kinosaalis ja Peet Areni maalid restorani keldrisaalis

  7. Brugbar peer feedback: Instruktion og træning før vi slipper de studerende løs

    DEFF Research Database (Denmark)

    Hvass, Helle; Heger, Stine

    2018-01-01

    Om den rammesætning og instruktion som studerende har behov for, hvis peer feedback skal fungere som læringsaktivitet i praksis.......Om den rammesætning og instruktion som studerende har behov for, hvis peer feedback skal fungere som læringsaktivitet i praksis....

  8. Ettekujutusi islami paradiisist ja paradiisineitsitest ning nende seos džihaadi ja märterlusega / Elo Süld

    Index Scriptorium Estoniae

    Süld, Elo, 1979-

    2012-01-01

    Ajaloolis-kriitiline pilt usklike ja märtrite tasuna oodatavast paradiisist, paradiisineitsite tõlgendamisest. Paradiisimotiivide aluseks olevatest religioossetest ettekujutustest (Koraan, judaistlik, kristlik ja zoroastrismi kontekst, sufismi allegooria, araabia luule, kreeka antiikmütoloogia)

  9. Rezension zu: Annemarie Bauer, Katharina Gröning (Hg.: Gerechtigkeit, Geschlecht und demografischer Wandel. Frankfurt am Main: Mabuse-Verlag 2008

    Directory of Open Access Journals (Sweden)

    Margret Karsch

    2009-07-01

    Full Text Available Der Sammelband belegt einmal mehr, dass Fürsorgeleistungen für Kinder und Ältere überwiegend von Frauen übernommen werden. Diese können und wollen die unbezahlte und oft unsichtbare Arbeit aber nicht mehr leisten – auch eine Frage der Gerechtigkeit. Die Autor/-innen plädieren für eine politische Debatte, um diesen Missstand aufzuheben. Wie wollen wir im Alter leben, was sind uns Unterstützung und Pflege wert? Die Fragen gehen uns alle an und verlangen eine gesamtgesellschaftliche Lösung. Da in Zukunft mehr alte Menschen auf Unterstützung angewiesen sein werden, muss die Fürsorge dringend neu organisiert werden.

  10. Milline on puuetega inimeste olukord hariduses ja tööturul ning mida arvate Anni Akadeemia laadsest eraalgatusest? / Vello Saliste, Kaja Plado, Kristin Veltri...[jt.

    Index Scriptorium Estoniae

    2010-01-01

    Küsimusele vastasid: Kosejõe kooli direktor Vello Saliste, Tartu ülikooli eripedagoogika programmijuht Kaja Plado, Haapsalu sanatoorse internaatkooli eripedagoog Kristin Veltri, Kiigemetsa kooli sotsiaalpedagoog Elo Palmiste, Tallinna ülikooli eripedagoogika osakonna juhataja Kadi Lukanenok

  11. Kuninganna Kristiina ning kunungas Karl XI : rootsiaegsed portreed raekojas = Queen Christina and King Karl XI : portraits of the Swedish period in the Town Hall / Pia Ehasalu

    Index Scriptorium Estoniae

    Ehasalu, Pia, 1964-

    2004-01-01

    Kuninganna Kristiina portreest lapsena (1638). Arvatav autor: Rootsi tolleaegne õuekunstnik Jacob Heinrich Elbfas või tema töökoda. Rootsi kuninga Karl XI noorpõlveportreest (1670). Autor: Karl XI õuekunstnik David Klöcker Ehrenstrahl (1628-1698)

  12. Automatic locking knee brace joint

    Science.gov (United States)

    Weddendorf, Bruce (Inventor)

    1995-01-01

    This invention is an apparatus for controlling the pivotal movement of a knee brace comprising a tang-and-clevis joint that has been uniquely modified. Both the tang and the clevis have a set of teeth that, when engaged, can lock the tang and the clevis together. In addition, the tang is biased away from the clevis. Consequently, when there is no axial force (i.e., body weight) on the tang, the tang is free to pivot within the clevis. However, when an axial force is exerted on the tang, the tang is pushed into the clevis, both sets of teeth engage, and the tang and the clevis lock together.

  13. Black ginseng-enriched Chong-Myung-Tang extracts improve spatial learning behavior in rats and elicit anti-inflammatory effects in vitro

    Directory of Open Access Journals (Sweden)

    Evelyn Saba

    2017-04-01

    Conclusion: Our research for the first time provides the scientific evidence that consumption of black ginseng-enriched CMT extract as a brain tonic improves memory impairment. Thus, our study results can be taken as a reference for future neurobehavioral studies.

  14. 2D geometric morphometric analysis casts doubt on the validity of large tanged points as cultural markers in the European Final Palaeolithic

    DEFF Research Database (Denmark)

    Serwatka, Kamil; Riede, Felix

    2016-01-01

    directeurs, especially in northern Europe. The vast majority of these finds are from the surface or derive from less-than-secure contexts. Several recent papers have cast doubt on the validity of this artefact class as a taxonomically sensitive marker. Here, we further investigate this issue using 2D...... arch-backed points. Their presence in later assemblages and technocomplexes such as the Brommean cannot therefore be considered as a derived or diagnostic feature. We suggest that this artefact class should rather be linked to weapon systems function (dart-points) different from the coeval arch...

  15. Métaux traces dans les sédiments d'une lagune méditerranéenne : l'étang de Thau

    OpenAIRE

    Pena, G; Picot, B

    1991-01-01

    Analyses of mineralogy, granulometry and chemistry - aluminium,cadmium, chromium, copper, iron, lead, manganese, mercury, nickel, zinc, organic carbon, total nitrogen and phosphorus - are carried out in a Mediterranean lagoon: Etang de Thau. Shell-fish breeding and tourism make the Thau basin an important place for studying the impact of pollution within a lagoon environment. The spatial distribution of the metallic elements is related to the fine fraction (< 63-mu-m) and to the organic matte...

  16. Therapeutic Effects of Saireito (Chai-Ling-Tang, a Traditional Japanese Herbal Medicine, on Lymphedema Caused by Radiotherapy: A Case Series Study

    Directory of Open Access Journals (Sweden)

    Aiko Nagai

    2013-01-01

    Full Text Available Despite the development of radiotherapy machines and technologies, a proportion of patients suffer from radiation-induced lymphedema. Saireito (SRT is a traditional Japanese herbal medicine that has been used for treating edema and inflammation in conditions such as nephritic disease. This study investigated the effect of SRT on lymphedema caused by radiotherapy. Four patients were treated with SRT at a dose of 9 g/day. The severity of lymphedema was evaluated using the Common Terminology Criteria for Adverse Events version 4 and Numerical Rating Scale before and after SRT treatment. After the treatment with SRT, 2 of 4 patients (50% showed apparent improvement in lymphedema. One of the cases had difficulty in wearing the custom-made thermoplastic cast, but after SRT administration, he could wear the mask easily. One case decided to stop taking SRT 3 days after initiation because cough and fever appeared. In conclusion, it is important to control the side effects of radiotherapy, which leads to improved tumor control rates. Prospective randomized studies are necessary to confirm the findings of this case series study.

  17. O murmúrio do tangível - A semântica tátil na sintaxe da superfície

    Directory of Open Access Journals (Sweden)

    Susana Maria Pires

    2017-10-01

    Full Text Available Poder-se-ia descrever a perceção tátil como a experiência de presença sem representação. Esta afirmação implicaria, no domínio das artes visuais, um discurso que, simultaneamente, afeta e se desvincula da problemática da ontologia da imagem e dos movimentos da linguagem. O sentido do tato é aquele que nos dá informação mais direta, real e concreta da superfície e corpo da matéria, no entanto a sua sintaxe é feita por relações abstratas. As qualidades e funções haptológicas dentro de cada cultura, o seu papel na comunicação e a forma como estas são afetadas pela tecnologia têm vindo a ganhar destaque nas criações artísticas contemporâneas, na academia e na sociedade em geral. Desdobrando o léxico do tato em sentido temático e função operativa, este artigo realiza uma breve trajetória ancorada na poética do tato no contexto das artes visuais. Paralelamente, indaga acerca da reciprocidade produtiva entre um pensamento centrado na funcionalidade tátil e o desenvolvimento de materiais interativos. ABSTRACT Tactile perception could be described as the experience of presence without representation. This point may not have a good framework in the issues of the image and language. The sense of touch is which gives us the truest information of real surfaces, still its syntax is made by abstract relations. The basic quality or function of touch within culture, the role of touch in communication and the ways in which touch is affected by technology are in our days an expanding field of research. Distinguishing touch between thematic sense and operating function, this paper makes a brief trajectory anchored in the poetics of touch in visual arts. Will be investigated simultaneously the relation between the touch thought and the smart textiles. KEYWORDS Touch, tangible, surface, contact, smart textiles.

  18. 论唐寅性格的女性化特征及成因%On TangYin's Feminized Personality and the Cause of Formation

    Institute of Scientific and Technical Information of China (English)

    王富鹏

    2006-01-01

    唐寅在其作品中,尤其是在他的散曲中常常自比女性,并常常以弃妇的形象出现.这些作品很明显地标示出了他人格的女性化特点.这些作品中的夫弃之怨,实质上是作者被抛出政治轨道的政治悲情.

  19. Microbial biodiversity of Tang and Pirgal mud volcanoes and evaluation of bio-emulsifier and bio-demulsifier activities of Capnophile bacteria.

    Science.gov (United States)

    Parsia, Yasaman; Sorooshian, Shahryar

    2017-12-01

    The data presented in this article is related to the Master thesis; entitled "Survey Aerobic Microbial Diversity Mud Volcanoes in Chabahar and Khash Ports in Southern Iran" by the first author of this article, year 2011, Islamic Azad University, Iran (reference number (Parsia, 2011) [1] of this article). This article shows microbial biodiversity and evaluates bio-emulsifier and bio-demulsifier abilities of capnophile isolates, in order to introduce a superior isolate for the Microbial Enhanced Oil Recovery (MEOR) process in the petrochemical industry.

  20. Structural characterisation of a water-soluble polysaccharide from tissue-cultured Dendrobium huoshanense C.Z. Tang et S.J. Cheng.

    Science.gov (United States)

    Si, Hua-Yang; Chen, Nai-Fu; Chen, Nai-Dong; Huang, Cheng; Li, Jun; Wang, Hui

    2018-02-01

    A water-soluble polysaccharide TC-DHPA4 with a molecular weight of 8.0 × 10 5  Da was isolated from tissue-cultured Dendrobium huoshanense by anion exchange and gel permeation chromatography. Monosaccharide analysis revealed that the homogeneous polysaccharide was made up of rhamnose, arabinose, mannose, glucose, galactose and glucuronic acid with a molar ratio of 1.28:1:1.67:4.71:10.43:1.42. The sugar residue sequence analysis based on the GC-MS files and NMR spectra indicated that the backbone of TC-DHPA4 consisted of the repeated units:→6)-β-Galp-(1→6)-β-Galp-(1→4)-β-GlcpA-(1→6)-β-Glcp-(1→6)-β-Glcp-(→. The sugar residue sequences β-Glcp-(1→)-α-Rhap-(1→3)-β-Galp-(1→, β-Glcp-(1→4)-α-Rhap-(1→3)-β-Galp-(1→, β-Galp-(1→6)-β-Manp-(1→3)-β-Galp-(1→, and α-l-Araf-(1→2)-β-Manp-(1→3)-β-Galp-(1→ were identified as the branches attached to the C-3 position of (1→6)-linked galactose in the backbone.

  1. Microbial biodiversity of Tang and Pirgal mud volcanoes and evaluation of bio-emulsifier and bio-demulsifier activities of Capnophile bacteria

    Directory of Open Access Journals (Sweden)

    Yasaman Parsia

    2017-12-01

    Full Text Available The data presented in this article is related to the Master thesis; entitled “Survey Aerobic Microbial Diversity Mud Volcanoes in Chabahar and Khash Ports in Southern Iran” by the first author of this article, year 2011, Islamic Azad University, Iran (reference number (Parsia, 2011 [1] of this article. This article shows microbial biodiversity and evaluates bio-emulsifier and bio-demulsifier abilities of capnophile isolates, in order to introduce a superior isolate for the Microbial Enhanced Oil Recovery (MEOR process in the petrochemical industry. Keywords: Mud volcanoes, Biodiversity, Bio-emulsification, Bio-demulsification, Petrochemistry

  2. Investeeringute ja erinevate toetuste ning käibemaksuskeemide kohaldamise mõju taimekasvatusettevõtte rahavoole = Effect of investments and various subsidies and application of value added tax schemes on crop cultivation enterprise's cash flow / J

    Index Scriptorium Estoniae

    Lehtsaar, Jüri, 1961-

    2005-01-01

    Kolme Eesti põllumajandusettevõtte 2003. aasta majandusnäitajate alusel loodud mudelettevõtte baasil tehtud analüüs investeeringute, toetuste ja alternatiivse käibemaksusüsteemi kohaldamise mõjude kohta. Selgitavad diagrammid. Tabel: Eesti põllumajandustootjate tulu kujunemine aastatel 2000-2003 mln kr; Skeem: Põllukultuuride ja teravilja kasvupind Eestis 2000-2004 tuh ha

  3. Eduard Tubina "Kogutud teoste" köidetest I/I (sümfooniad nr. 1 ja 2) ning I/VII (orkestrisüidid) / Timo Virtanen ; (tõlkinud Merike Vaitmaa)

    Index Scriptorium Estoniae

    Virtanen, Timo, 1956-

    2013-01-01

    Arvustus: Lauri Sirp, Toomas Trass (toim.). Kogutud teosed. I seeria, I köide : Sümfoonia nr. 1 ; Sümfoonia nr. 2 : Legendaarne / Eduard Tubin. Stockholm : Rahvusvaheline Eduard Tubina Ühing ; Gehrmans Musikförlag, 2012

  4. 辽宁省大豆优异种质资源的利用%Study on utilization of high quality soybean seed source of LiaoNing province

    Institute of Scientific and Technical Information of China (English)

    梁成第; 郭迎伟; 王立敏

    2003-01-01

    辽宁省铁岭大豆研究所在1986-1996年间,先后对全省保存的916份大豆品种资源进行系统鉴定与评价.从中鉴定出优异抗旱资源39份,优异抗病资源77份,优异抗虫资源175份,耐瘠资源40份.

  5. Noor, ambitsioonikas, haritud... ning pokaaliga pildid Facebookis?! : töö otsimisel muutub Facebook üha tähtsamaks. Mõned nipid noorele tööotsijale / Kadri Eisenschmidt

    Index Scriptorium Estoniae

    Eisenschmidt, Kadri

    2013-01-01

    Tallinna Ülikooli sotsioloogia eriala lõpetanud Kadri Eisenschmidti artikkel annab ülevaate tema bakalaureusetööst, mille eesmärk oli selgitada, kas ja kuidas mõjutavad sotsiaalvõrgustikud noorte võimalusi töökoha leidmisel

  6. Elektroonilise rämpspostituse olemus. Rämps e-posti saatmisega kahju õigusvastane tekitamine e-kirja teenuse kasutajatele ning Interneti teenuse pakkujatele. Probleemi seadusandlik lahendus : [bakalaureusetöö] / Veiko Vahimets ; Tartu Ülikool,

    Index Scriptorium Estoniae

    Vahimets, Veiko

    2003-01-01

    Elektroonilise rämpsposti olemus - õigusliku regulatsiooni vajalikkus, elektrooniline rämpspostitus ja deliktiõigus, elektroonilise rämpspostituse vastase seadusandluse arengusuunad (Ameerika Ühendriikides, Kanadas, Austraalias, Taiwanil, Euroopa Liidus, Eestis)

  7. Kohtueelses menetluses antud ütluste kasutamine kohtumenetluses EV Riigikohtu ja Euroopa Inimõiguste Kohtu seisukohad ning SE 599 rakendunud muutused : [bakalaureusetöö] / Agu Aver ; Tartu Ülikool, õigusteaduskond ; juhendaja: Eerik Kergandberg

    Index Scriptorium Estoniae

    Aver, Agu

    2012-01-01

    Eesti kriminaalmenetluse arengust, võistlevusest, Euroopa Inimõiguste ja Põhivabaduste kaitse konventsiooni artiklist 6 lõige 3 p (d), kohtueelses menetluses antud ütluste avaldamisest KrMS kohaselt, kuulduste keelust

  8. [Mis teemal peaks kirjutama tänapäeval sellise "40 kirja", millele te allkirja andmist võiksite kaaluda ning mis mõjuks ühiskonnas värske õhu puhanguna?

    Index Scriptorium Estoniae

    2010-01-01

    Küsimusele vastavad 1980. aastal koostatud "40 kirjale" allakirjutanud kultuuri- ja ühiskonnategelased P. Lorents, P. Kask, H. Kiik, T. Kall, T. Kaljuste, M. Kalda, A. Langemets, K. Alttoa, M. Hint, F. Jüssi, P. Aimla, L. Hainsalu, M. Lauristin, J. Klõšeiko, A. Laats, K. Kreismann, A. Laht, R. Ruutsoo, L. Tavel, A. Valton, P. Tulviste, P.-E. Rummo, T. Rätsep, R. Tamsalu, A. Tarand, E. Nirk, M. Sirkel ja J. Tamm

  9. Kohtupsühhiaatrilist ekspertiisi ja sundravi reguleerivate õigusaktide rakendamine ning võimalikud muudatused : [magistritöö] / Kaupo Piirsalu ; Tartu Ülikool, õigusteaduskond ; juhendajad: Jaan Ginter, Kadri Andresen

    Index Scriptorium Estoniae

    Piirsalu, Kaupo

    2012-01-01

    Õigusharude-vahelistest ekspertiisi- ja sundravialastest regulatsioonidest, kohtupsühhiaatsiaekspertiisist, õigusharude-ülesest regulatsiooni võimalikkusest ja põhiõiguste tagamisest, võrdlusest teiste riikidega, muudatustest ja ettepanekutest

  10. Uniprindi büroo- ja trükikojahoone : edu peatänavatest, Uniprindi trükikojast ning geneerilisest arhitektuurist = Success from Main Streets, Uniprint Printing Plant, and Generic Architecture / Veljo Kaasik

    Index Scriptorium Estoniae

    Kaasik, Veljo

    2000-01-01

    Pärnu mnt. ristmiku juurde Tallinnas R. Puusepa arhitektibüroo poolt trükikojale Uniprint projekteeritud büroo-tootmishoonest. Arhitektid Raivo Puusepp, Krista Väärtnõu. Konstruktsioonid: Projektbüroo Teinos, Civen OÜ. Projekt 1999-2000, hoone valmis 2000. Peatänavaid ääristava hoonestuse kiirest muundumisest. 9 ill.: korruste plaanid, lõiked, vaated (joon.); välisvaated (foto)

  11. Väljendusvabaduse liberaalsed kontseptsioonid ja nende kajastumine rahvusvahelises ning siseriiklikus õiguses : [bakalaureusetöö] / Ksenia Žurakovskaja ; Tartu Ülikool, õigusteaduskond ; juhendaja: Lauri Mälksoo

    Index Scriptorium Estoniae

    Žurakovskaja, Ksenia, 1984-

    2006-01-01

    "Sõna" definitsioon ja väljenduse vorm, liberaalsete väljendusvabaduse kontseptsioonide juriidiline teostamine (John Stuart Mill), väljendusvabadus kui eneseteostuse ja demokratiseerumise tähtsaim element

  12. Lepingulise esindaja õigus ütluste andmisest keelduda tsiviilkohtumenetluses ning selle õiguse seos konfidentsiaalsuskohustusega : [magistritöö] / Jako Laanemägi ; Tartu Ülikool, õigusteaduskond ; juhendaja: Andreas Kangur

    Index Scriptorium Estoniae

    Laanemägi, Jako

    2010-01-01

    Ütluste andmisest tsiviilprotsessis, advokaadi osast, õigusnõustaja rollist, prokuristist e. menetlusosalise lepingulisest esindajast kohtumenetluses, notari osast, muu isiku rollist (nt. patendivolinik)

  13. Reservatsioonide lubatavus ning reservatsioonide vastuväidete õiguslik mõju ILC uurimistöö valguses : [bakalaureusetöö] / Marja-Liisa Laatsit ; Tartu Ülikool, õigusteaduskond ; juhendaja: Lauri Mälksoo

    Index Scriptorium Estoniae

    Laatsit, Marja-Liisa

    2009-01-01

    ILC = International Law Commission. - Reservatsioonidest tänases teoorias ja praktikas, vastuväidetest reservatsioonide tegemisele, reservatsioonide lubatavusest ja nende õiguslikust mõjust (ILC eriraportöör Pellet̀ettepanekutest, NATO SOFA lepingust)

  14. Vaidluste lahendamine ning lahendite läbivaatuse eesmärk ICSID süsteemis : [bakalaureusetöö] / Tanel Ader ; Tartu Ülikool, õigusteaduskond ; juhendaja: Aleksandr Popov

    Index Scriptorium Estoniae

    Ader, Tanel

    2012-01-01

    ICSID (Rahvusvaheline Investeerimisvaidluste Lahendamise Keskus = International Centre for Settlement of Investment Disputes) eelsest õiguslikust olukorrast, konventsiooni eesmärkidest, Maailmapanga põhimõtete täitmisest, kahjutasu tunnustamisest ja väljanõudmisest, riikide suveräänsest puutumatusest

  15. Ühiskondlik süüdistus : EV Ülemkohtu esimehe, nõukogude teenelise juristi J. Kirikali, Ülemkohtu liikmete U. Penderi ja A. Viljardi ning EV prokuröri L. Urge vastu / Enn Sarv

    Index Scriptorium Estoniae

    Sarv, Enn, 1921-2008

    1992-01-01

    1991. a. 27. veebruari Ülemkohtu pleenumi määrusest, mis puudutas 1946. a. süüdi mõistetud koolinoori (Ageeda-Andrea Paavel, Aili Jürgenson, Eino Valdmaa, Lia Frei, Juhan Kuusk). Lisatud määruse täistekst

  16. Õiguspärane sundvõõrandamine rahvusvahelises õiguses ning maagaasiseaduse ja majandustegevuse seadustiku üldosa seaduse muutmise seaduse eelnõus : [magistritöö] / Kristjan Kotkas ; Tartu Ülikool, õigusteaduskond ; juhendaja: Maarja Torga

    Index Scriptorium Estoniae

    Kotkas, Kristjan

    2012-01-01

    Sundvõõrandamisest ja selle lubatavusest rahvusvahelises õiguses, eelnõus toodud meetmete analüüsist rahvusvahelise õiguse taustal, õiguspärase sundvõõrandamise tingimuste olemasolust eelnõus

  17. Chemical Profiling of Re-Du-Ning Injection by Ultra-Performance Liquid Chromatography Coupled with Electrospray Ionization Tandem Quadrupole Time-of-Flight Mass Spectrometry through the Screening of Diagnostic Ions in MSE Mode

    Science.gov (United States)

    Wang, Zhenzhong; Geng, Jianliang; Dai, Yi; Xiao, Wei; Yao, Xinsheng

    2015-01-01

    The broad applications and mechanism explorations of traditional Chinese medicine prescriptions (TCMPs) require a clear understanding of TCMP chemical constituents. In the present study, we describe an efficient and universally applicable analytical approach based on ultra-performance liquid chromatography coupled to electrospray ionization tandem quadrupole time-of-flight mass spectrometry (UPLC-ESI-Q/TOF-MS) with the MSE (E denotes collision energy) data acquisition mode, which allowed the rapid separation and reliable determination of TCMP chemical constituents. By monitoring diagnostic ions in the high energy function of MSE, target peaks of analogous compounds in TCMPs could be rapidly screened and identified. “Re-Du-Ning” injection (RDN), a eutherapeutic traditional Chinese medicine injection (TCMI) that has been widely used to reduce fever caused by viral infections in clinical practice, was studied as an example. In total, 90 compounds, including five new iridoids and one new sesquiterpene, were identified or tentatively characterized by accurate mass measurements within 5 ppm error. This analysis was accompanied by MS fragmentation and reference standard comparison analyses. Furthermore, the herbal sources of these compounds were unambiguously confirmed by comparing the extracted ion chromatograms (EICs) of RDN and ingredient herbal extracts. Our work provides a certain foundation for further studies of RDN. Moreover, the analytical approach developed herein has proven to be generally applicable for profiling the chemical constituents in TCMPs and other complicated mixtures. PMID:25875968

  18. Õigusvastaselt võõrandatud vara tagastamine ja kompenseerimine ning sellega seotud kohtulikud vaidlused : [bakalaureusetöö] / Eve Lill ; Tartu Ülikool, õigusteaduskond ; juhendaja: Kalle Merusk

    Index Scriptorium Estoniae

    Lill, Eve

    1996-01-01

    Õigusvastaselt võõrandatud vara tagastamise ja kompenseerimise menetlus ja vaidlused, halduskohtu pädevus ja vaidluste liigid seoses õigusvastaselt võõrandatud vara tagastamise ja kompenseerimisega

  19. Piinamise ja ebainimliku või alandava kohtlemise või karistamise tõkestamise Euroopa konventsioon ja Komitee ning Eesti kohta koostatud raportite vanglaid puudutav osa : [bakalaureusetöö] / Mariko Jõeorg ; Tartu Ülikool, õigusteaduskond ; juh

    Index Scriptorium Estoniae

    Jõeorg, Mariko

    2003-01-01

    Euroopa Nõukogust, piinamise ja ebainimliku või alandava kohtlemise või karistamise tõkestamise Euroopa konventsiooni loomine, mõisted, Komitee visiidid Eestisse ja raportid vanglate kohta (1997, 1999), Eesti vastulaused

  20. Motoorika areng eelkoolieas ning selle mõju õpiedukusele esimeses klassis = The development of motor at preschool age and its influence on academic achievement in their first form : I koht magistritööde kategoorias / Kristi Heilman

    Index Scriptorium Estoniae

    Heilman, Kristi

    2009-01-01

    Uuringu ülesandeks oli välja selgitada koolieelikute liigutusoskuste tase sõltuvalt liikumistundide arvust lasteaia õppenädalas ja püüda välja selgitada liikumisoskuste mõju lapse õpiedukusele esimeses klassis

  1. Süüteovahendi konfiskeerimise eesmärk ja õiguslik olemus ning selle põhiseaduslik õigustus. Riigikohtu üldkogu otsus asjas 3-1-1-37-07 / Andres Parmas

    Index Scriptorium Estoniae

    Parmas, Andres, 1977-

    2008-01-01

    Riigikohtu lahendist 3-1-1-37-07 (Toomas Tiiki kaitsja vandeadvokaadi abi Anti Aasmaa kassatsioon Viru Ringkonnakohtu 22. märtsi 2007. a kohtuotsuse peale kriminaalasjas Toomas Tiiki süüdistuses KarS § 424 järgi)

  2. Carbon nanotube-incorporated collagen hydrogels improve cell alignment and the performance of cardiac constructs

    Directory of Open Access Journals (Sweden)

    Sun HY

    2017-04-01

    Full Text Available Hongyu Sun,* Jing Zhou,* Zhu Huang,* Linlin Qu,* Ning Lin,* Chengxiao Liang, Ruiwu Dai, Lijun Tang, Fuzhou Tian General Surgery Center, Chengdu Military General Hospital, Chengdu, China *These authors contributed equally to this work Abstract: Carbon nanotubes (CNTs provide an essential 2-D microenvironment for cardiomyocyte growth and function. However, it remains to be elucidated whether CNT nanostructures can promote cell–cell integrity and facilitate the formation of functional tissues in 3-D hydrogels. Here, single-walled CNTs were incorporated into collagen hydrogels to fabricate (CNT/Col hydrogels, which improved mechanical and electrical properties. The incorporation of CNTs (up to 1 wt% exhibited no toxicity to cardiomyocytes and enhanced cell adhesion and elongation. Through the use of immunohistochemical staining, transmission electron microscopy, and intracellular calcium-transient measurement, the incorporation of CNTs was found to improve cell alignment and assembly remarkably, which led to the formation of engineered cardiac tissues with stronger contraction potential. Importantly, cardiac tissues based on CNT/Col hydrogels were noted to have better functionality. Collectively, the incorporation of CNTs into the Col hydrogels improved cell alignment and the performance of cardiac constructs. Our study suggests that CNT/Col hydrogels offer a promising tissue scaffold for cardiac constructs, and might serve as injectable biomaterials to deliver cell or drug molecules for cardiac regeneration following myocardial infarction in the near future. Keywords: carbon nanotubes, collagen hydrogel, cardiac constructs, cell alignment, tissue functionality

  3. HOTEL INFORMATION

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Holiday Inn Central Plaza Beijing Tyrone Tang is the newly appointed general manager of Holiday Inn Central Plaza, Beijing.Tang joined IHGin2002.He was transferred from the position of operations manager.

  4. SIAH and EGFR, Two RAS Pathway Biomarkers, are Highly Prognostic in Locally Advanced and Metastatic Breast Cancer

    Directory of Open Access Journals (Sweden)

    Lauren L. Siewertsz van Reesema

    2016-09-01

    Funding: This work was supported by the Dorothy G. Hoefer Foundation for Breast Cancer Research (A.H. Tang; Center for Innovative Technology (CIT-Commonwealth Research Commercialization Fund (CRCF (MF14S-009-LS to A.H. Tang, and National Cancer Institute (CA140550 to A.H. Tang.

  5. Jiang Tang Xiao Ke Granule Play an Anti-diabetic Role in Diabetic Mice Pancreatic Tissue by Regulating the mRNAs and MicroRNAs Associated with PI3K-Akt Signaling Pathway

    Directory of Open Access Journals (Sweden)

    Fang-Fang Mo

    2017-11-01

    Full Text Available Purpose: To investigate the effect of JTXK granule on the expression pattern of miRNA in pancreatic tissue of KKAy diabetic mice, and to explore the molecular mechanism and pathways of JTXK granule in anti-diabetic effect.Methods: We used high fat diet (HFD to induce the KKAy diabetic mice and screened the differentially expressed miRNAs (DEMs between JTXK-treated group (n = 6 and the diabetic group (n = 6 using MicroRNA (miRNA Microarray. C57BL/6J mice were given a normal diet as the control group (n = 6. Subsequently, miRNA target gene prediction, GO and Pathway analysis were used to explore the function of DEMs. Finally, the mechanism of anti-diabetic effects of JTXK granule was tested by in vitro INS-1 pancreatic β-cell experiment.Results: The blood glucose and body weight of JTXK-treated group was significantly lower compared with the model group. Moreover, a total of 45 miRNAs with significant differences were detected in the model group and the JTXK-treated group (P ≤ 0.05, Fold Change > 2. Further, miRNA-mRNA analysis showed that the differential expression of mmu-miR-192-5p, mmu-miR-291a-3p, mmu-miR-320-3p, mmu-miR-139-5p and mmu-miR-378a-3p are closely related to pancreatic histological changes. In addition, pathway analysis showed that the DEMs were closely related to PI3K-Akt Signaling Pathway. Furthermore, the levels of serine/threonine-protein kinase (Akt, phosphorylated Akt (p-Akt and phosphorylated forkhead transcription factor O1 (p-Foxo1 in INS-1-FOXO1 overexpressing model cells were lower than those in normal group, while JTXK granules could increase the expression of Akt, p-Akt and p-Foxo1.Conclusions: The results showed that JTXK granule could play an anti-diabetic role by regulating the mRNA and miRNAs associated with PI3K-Akt pathway in diabetic mice pancreatic tissue.

  6. Mapping of the Bak, Tang, and Wiesenfeld sandpile model on a two-dimensional Ising-correlated percolation lattice to the two-dimensional self-avoiding random walk

    Science.gov (United States)

    Cheraghalizadeh, J.; Najafi, M. N.; Dashti-Naserabadi, H.; Mohammadzadeh, H.

    2017-11-01

    The self-organized criticality on the random fractal networks has many motivations, like the movement pattern of fluid in the porous media. In addition to the randomness, introducing correlation between the neighboring portions of the porous media has some nontrivial effects. In this paper, we consider the Ising-like interactions between the active sites as the simplest method to bring correlations in the porous media, and we investigate the statistics of the BTW model in it. These correlations are controlled by the artificial "temperature" T and the sign of the Ising coupling. Based on our numerical results, we propose that at the Ising critical temperature Tc the model is compatible with the universality class of two-dimensional (2D) self-avoiding walk (SAW). Especially the fractal dimension of the loops, which are defined as the external frontier of the avalanches, is very close to DfSAW=4/3 . Also, the corresponding open curves has conformal invariance with the root-mean-square distance Rrms˜t3 /4 (t being the parametrization of the curve) in accordance with the 2D SAW. In the finite-size study, we observe that at T =Tc the model has some aspects compatible with the 2D BTW model (e.g., the 1 /log(L ) -dependence of the exponents of the distribution functions) and some in accordance with the Ising model (e.g., the 1 /L -dependence of the fractal dimensions). The finite-size scaling theory is tested and shown to be fulfilled for all statistical observables in T =Tc . In the off-critical temperatures in the close vicinity of Tc the exponents show some additional power-law behaviors in terms of T -Tc with some exponents that are reported in the text. The spanning cluster probability at the critical temperature also scales with L1/2, which is different from the regular 2D BTW model.

  7. QUALITÉ NUTRITIVE DE L’ALIMENTATION NATURELLE DU TILAPIA OREOCHROMIS NILOTICUS EN ÉLEVAGE EXTENSIF DANS DES ÉTANGS DE BARRAGE (CÔTE D’IVOIRE

    Directory of Open Access Journals (Sweden)

    BLE M. C.

    2007-04-01

    Full Text Available La composition chimique des sources alimentaires (périphyton, matières en suspension et sédiment et celle des contenus stomacaux d’Oreochromis niloticus en élevage extensif dans deux barrages situés en zone rurale (Gueyo, Sud-Ouest de la Côte d’Ivoire ont été déterminées afin d’apprécier la qualité de la nourriture naturelle ingérée par ces poissons. Les proportions des différents constituants chimiques mesurés dans ces trois sources alimentaires laissent apparaître la part importante que représentent les matières organiques hydrolysables dans le périphyton (65 et 67 % aux barrages 1 et 2, respectivement, alors que les matières minérales constituent plus de la moitié du poids sec total des matières en suspension (59 et 63 % et de la ressource sédimentaire (76 et 63 %. Sur les deux sites, les fibres représentent moins de 15 % de ces trois ressources. Les teneurs en protéines (19 % et le ratio Protéines/Énergie (17 mg.kJ-1 observés dans la ressource périphytique sont respectivement 2 et 3 fois supérieurs aux valeurs mesurées dans les deux autres ressources. L’analyse biochimique des contenus stomacaux montre que les protéines sont présentes en très faibles proportions dans la nourriture ingérée par O. niloticus (7 et 11 % dans les deux barrages. Par contre, les proportions en fibres (12 et 16 % et lipides (11 et 8 % de même que les ratios Protéines/Énergie (6 et 12 mg.kJ-1 caractérisant l’alimentation semblent répondre aux exigences de croissance chez cette espèce de tilapia. Les poids moyens des poissons en fin de cycle d’élevage traduisent la capacité d’O. niloticus à présenter une croissance correcte à partir d’une alimentation pauvre en matières azotées pourvu qu’une faible densité soit appliquée dans les sites d’élevage.

  8. Competências na era digital: desafios tangíveis para bibliotecários e educadores/Competencies in the digital era: challenges and equipment for educators and librarians

    Directory of Open Access Journals (Sweden)

    Regina Célia Baptista Belluzzo

    2005-01-01

    Full Text Available A partir de uma abordagem do mundo contemporâneo, dos novos paradigmas, da consciência planetária, da globalização, chegar-se-á à era digital, destacando-se os seus impactos sobre a valorização da informação e do conhecimento como bens de valor. Ressalta-se que a produção do conhecimento, na atualidade, é uma questão fundamental, tratando-se de uma teoria voltada à sua própria prática: ao mesmo tempo em que a fundamenta, subordina-se a ela, implicando necessariamente em mudanças no modo de pensar/atuar das pessoas. A educação também é parte desse cenário de mudanças e existem razões para que seja um referencial diferenciado na chamada “ sociedade em rede”, sendo uma situação emergente a mudança de postura no que diz respeito à migração da sua identidade como transmissora de informação e de cultura para uma condição de ensinar a aprender e a pensar, preparando pessoas para que prolonguem os benefícios da escola além da escola mesma, tornando funcionais os conhecimentos adquiridos e, sobretudo, para que saibam empregar o poder da inteligência na vida profissional e no seu cotidiano. Desse modo, enfatiza-se a importância da educação, sob enfoque de um novo paradigma conceitual e prático, voltada para a formação de cidadãos capazes de integrarem-se à era digital, cujo princípio fundamental acha-se embasado no desenvolvimento de competências para o uso da informação e na capacidade intelectual de transformá-la em conhecimento., com uma inovadora condição de aprendizado contínuo e crescente. Tudo isso frente aos desafiadores avanços tecno-científicos dos últimos tempos. A desinformação nessa era é talvez a razão da existência de muitos problemas sociais, uma vez que atinge o ser humano em sua maior propriedade: a racionalidade. O conhecimento é, portanto, o fator competitivo entre as pessoas e as sociedade, sendo importante ressaltar que do seu uso racional e da sua aplicação é que conseguimos caminhar rumo à inovação e desenvolvimento social. A transferência e a aplicabilidade dos princípios da aprendizagem significativa de Ausubel e do uso dos mapas conceituais merecem lugar de destaque , emergindo a sua representatividade como facilitadores das condições de trabalho integrado entre bibliotecários e educadores, os quais são co-responsáveis pelo desenvolvimento das competências características dessa sociedade em mudança, destacando-se dentre elas a competência em informação, tema em discussão no contexto mundial. Essas reflexões apresentadas pretendem focalizar, em síntese, a era digital e suas implicações para os profissionais da informação e da educação, destacando-se a importância da informação e do conhecimento como balizadores do processo de inovação e desenvolvimento social e as principais questões relacionadas à competência em informação, tendo como enfoque a aprendizagem significativa. From a boarding of the world contemporary, of the new paradigms, the planetary conscience, the globalization, the digital age will be arrived it, being distinguished its impacts on the valuation of the information and the knowledge as value good. It is standed out that the production of the knowledge, in the present time, is a basic question, being about a proper theory directed to its practical one: at the same time where it bases it, it is subordinated it, implying necessarily in changes in the way of pensar/atuar of the people. The education also is part of this scene of changes and exists reasons so that it is a referencial differentiated in the call "society in net", being an emergent situation the position change in that it says respect to the migration of its identity as transmissing of information and culture for a condition to teach to learn and to think, preparing people so that they draw out the benefits of the school beyond the same school, becoming functional acquired knowledge e, over all, so that they know to use the power of intelligence in the life professional and its daily one. In this way, importance of the education is emphasized it, under approach of a new conceptual and practical paradigm, come back toward the formation of citizens capable to combine it the digital age, whose basic principle is found based in the development of abilities for the use of the information and in the intellectual capacity to transform it into knowledge, with an innovative condition of continuous and increasing learning. Everything this front to the challenging tecno-scientific advances of the last times. The disinformation in this age is perhaps the reason of the existence of many social problems, a time that reaches the human being in its bigger property: the rationality. The knowledge is, therefore, the competitive factor between the people and the society, being important to stand out that of its rational use and its application it is that we obtain to walk route to the innovation and social development. The transference and the applicability of the principles of the significant learning of Ausubel and the use of the conceptual maps deserve prominence place, emerging its representation as facilitator of the conditions of work integrated between librarians and educators, which are co-responsible for the development of the characteristic abilities of this society in change, being distinguished amongst them the ability in information, subject in quarrel in the world-wide context. These presented reflections intend to focus, in synthesis, the digital age and its implications for the professionals of the information and the education, being distinguished it importance of the information and the knowledge as makers of the innovation process and social development and the main questions related to the ability in information, having as approach the significant learning.

  9. Itaallane Giulietto Chiesa - 9/11 tabulõhkuja / Ivari Vee

    Index Scriptorium Estoniae

    Vee, Ivari

    2008-01-01

    Itaalia publitsist ja politoloog ning Europarlamendi saadik Giulietto Chiesa kohtus Tallinnas ajakirjanike ja teiste huvilistega ning tutvustas oma raamatut "Zero" ning selle ainetel valminud filmi "9/11. Uurimine nullist"

  10. Kaadris: "Naerata ometi" / Ulve Määrits

    Index Scriptorium Estoniae

    Määrits, Ulve

    2012-01-01

    Restaureeriti mängufilm "Naerata ometi". Sel puhul toimus ringreis Tilsis ning taastatud filmi esitlus Põlva kultuurikeskuses, kus osalesid ning meenutasid filmi valmimist ka lavastaja Arvo Iho ning osatäitjad Katrin Tamleht ja Kerttu Aaving

  11. Two steps forward, one step back? : the field of womeǹs human rights / Hilary Charlesworth

    Index Scriptorium Estoniae

    Charlesworth, Hilary

    2014-01-01

    Sümpoosion naiste inimõigustest ning vastava seadusandluse problemaatilisusest. Lisaks naiskohtunike mõjust kohtusüsteemile Euroopa Inimõiguste Kohtus, abordist ning vastavast seadusandlusest Suurbritannias, naistevastasest vägivallast ning lesbiliste suhete õiguslikust regulatsioonist

  12. "Retsh Pospolita energetitshna" / Vladimir Skripov

    Index Scriptorium Estoniae

    Skripov, Vladimir

    2007-01-01

    Euroopa Komisjoni energiapoliitika-alased dokumendid ning Venemaa energiatarnete katkestused on sundinud Baltimaid ja Poolat tegema koostööd uute elektrikaablite ehitamise ning tuumaenergia kasutuse laiendamiseks ning otsima alternatiivseid sihtkohti naftaimpordiks

  13. Informatsioon, juhtimine, infotehnoloogia ja infotehnoloogia juhtimine / Vambola Leping

    Index Scriptorium Estoniae

    Leping, Vambola

    2004-01-01

    Infotehnoloogia juhtimise vajadusest, võimalustest ettevõtetes ning organisatsioonides, informatsiooni ja andmete vahekorrast ning seosest juhtimisega, infotehnoloogia juhtimise kooslusmudelist. Skeem. Diagramm

  14. Kust leida naissoost meest? / Ramo Pener

    Index Scriptorium Estoniae

    Pener, Ramo

    2016-01-01

    Mõistest Gender Mainstreaming ning selle hukutava maailmavaate tagamaadest. Adekvaatse identiteedi kujunemise kaasaaitamisel on oluline aidata kaasa soorollide kujunemisele, selgitamisele ning toetamisele

  15. Privatisation of enterprises of infrastructure : why did it misfire? / Heido Vitsur

    Index Scriptorium Estoniae

    Vitsur, Heido, 1944-

    2002-01-01

    Edelaraudtee ning Narva elektrijaamade erastamisest, sellega seonduvatest probleemidest ning viimastest arengutest. Lisad: Muutused maksunduses; Balti riikide kõige kallim ja odavam pealinn; Aastatehingud Eestis

  16. Vello Viirsalu - Orienteeruja Kuldsulg 9. VII 1938 - 23. III 2011 / Heino Mardiste

    Index Scriptorium Estoniae

    Mardiste, Heino, 1936-

    2011-01-01

    Pikaaegsest Tartu Onkoloogiahaigla radioloogist ja statistikakabineti juhatajast, kes oli ka orienteerumisspordi harrastaja ning eestvedaja - orjenteerumiskaartide koostaja, OK Kape asutaja ning orienteerumisspordi ajaloouurija jne

  17. Õpilane / Kristina Lindemann

    Index Scriptorium Estoniae

    Lindemann, Kristina, 1984-

    2016-01-01

    Rahvusvahelise õpilaste hindamisprogrammi PISA 2015. aasta uuringu tulemuste analüüs, mis näitab, kuidas õpilaste sotsiaalmajanduslik taust ning tegevused seostuvad sooritustulemustega ning tulevikuootustega

  18. Automatic locking orthotic knee device

    Science.gov (United States)

    Weddendorf, Bruce C. (Inventor)

    1993-01-01

    An articulated tang in clevis joint for incorporation in newly manufactured conventional strap-on orthotic knee devices or for replacing such joints in conventional strap-on orthotic knee devices is discussed. The instant tang in clevis joint allows the user the freedom to extend and bend the knee normally when no load (weight) is applied to the knee and to automatically lock the knee when the user transfers weight to the knee, thus preventing a damaged knee from bending uncontrollably when weight is applied to the knee. The tang in clevis joint of the present invention includes first and second clevis plates, a tang assembly and a spacer plate secured between the clevis plates. Each clevis plate includes a bevelled serrated upper section. A bevelled shoe is secured to the tank in close proximity to the bevelled serrated upper section of the clevis plates. A coiled spring mounted within an oblong bore of the tang normally urges the shoes secured to the tang out of engagement with the serrated upper section of each clevic plate to allow rotation of the tang relative to the clevis plate. When weight is applied to the joint, the load compresses the coiled spring, the serrations on each clevis plate dig into the bevelled shoes secured to the tang to prevent relative movement between the tang and clevis plates. A shoulder is provided on the tang and the spacer plate to prevent overextension of the joint.

  19. Mäletamine ja nostalgia Karl Ristikivi romaanis „Kõik, mis kunagi oli” ning Bernard Kangro Joonatani -romaanides. Remembering and Nostalgia in Karl Ristikivi`s novel „All that Once Was” and Bernard Kangro’s Joonatan-novels

    Directory of Open Access Journals (Sweden)

    Maarja Hollo

    2012-04-01

    Full Text Available Research on the phenomenon of nostalgia has been notably shaped by the interest taken by sociologists, historians, and ethnologists in the ways of remembering past events and the impact of these ways of reminiscence on different communities of memory. This article considers remembering in a narrower sense, focusing on the modes of expression of individual memory, that is, on nostalgia. More specifically, nostalgia is defined as a conglomeration of feelings, images and interpretations that accompany individual remembering; the contradictions between these elements reflect the tensions inherent in remembering. The purpose of the article is first to emphasize ways in which remembering is represented in the works of two Estonian writers who went into exile during World War II; second, differences among their novels which thematize remembering, and third, how these works communicate today, in the context of recent polemics around memory. Karl Ristikivi’s novel „All that Once Was” (Kõik, mis kunagi oli”, 1946, was his first work to be published in exile, and the first volume of a dilogy set in Estonia, which the writer had already planned before fleeing Estonia. The first volume of Bernard Kangro’s Joonatan trilogy was published in 1971, and the last in 1973 – a period of creative crisis for Kangro, in which his prose writing undergoes significant change. In the works of both Ristkivi and Kangro, remembering and nostalgia are inextricably bound together. In Ristikivi’s novel, the connections emerge through the parallel representation of remembering, events in historical time, and the writing of history; in Kangro’s novels, in the force field of remembering and events in historical time. Ristikivi’s novel is set a few months before the conclusion of the Molotov- Ribbentrop pact in August, 1939. The novel’s focus, however, is not on the historical events themselves, but rather on how characters experience and interpret their own personal past and present. The novel shows how personal remembering differs from the logic of cultural memory, and seems to confirm that remembering maintains a certain autonomy from historical time. Such an understanding of memory can be taken as an effort to critique attempts to politicize memory. Ristikivi stresses qualities of individual remembering such as self-enclosure and refusal to submit to efforts at collectivization and assimilation. This kind of memory is only for the characters themselves to know; never once do they express their memories in language. As concerns nostalgia, Ristikivi’s novel emphasizes its connection with forgetting: in their retrospection and recollection, characters remember only extraordinary events in their lives, but not the texture of their everyday lives. Like Ristikivi, Kangro also speaks of the connections between nostalgia and remembering. In his Joonatan-novels, however, nostalgia has a more ambivalent meaning. The protagonist of the Joonatan novels, who has just returned to the homeland from exile, feels the tension between his wish to reconcile himself with the past and the nostalgic memories that flood him in the homeland. On the one hand, indulging in nostalgia tears him away from the wish to remember painful past events, and with this from present reality; on the other hand, his nostalgia helps him overcome a traumatic past. In both Ristikivi’s and Kangro’s novels nostalgic memories are connected with personally meaningful places, to which they return again and again.

  20. Ravi rahastamise lepingu sõlmimise menetluse regulatsiooni ja selle alusel Eesti Haigekassa poolt välja kujundatud halduspraktika kitsaskohad ning nende ületamise võimalused : [magistritöö] / Alle-Riin Nõgols ; Tartu Ülikool, õigusteaduskond

    Index Scriptorium Estoniae

    Nõgols, Alle-Riin

    2012-01-01

    Ravi rahastamise lepingu olemusest ja sõlmimiseks läbiviidavast haldusmenetlusest, Eesti Haigekassa õiguslikust seisundist EL konkurentsiõiguse tähenduses, tervishoiuteenuse osutajate võrdse kohtlemise võimalustest ravi rahastamise lepingute sõlmimise protsessis

  1. Age as a risk factor for acute mountain sickness upon rapid ascent to 3,700 m among young adult Chinese men

    Directory of Open Access Journals (Sweden)

    Tang XG

    2014-08-01

    Full Text Available Xu-gang Tang,1 Ji-hang Zhang,1 Jun Qin,1 Xu-bin Gao,1 Qian-ning Li,2 Jie Yu,1 Xiao-han Ding,1 Lan Huang1 1Institute of Cardiovascular Diseases, 2Department of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing, People’s Republic of China Background: The aim of this study was to explore the relationship between age and acute mountain sickness (AMS when subjects are exposed suddenly to high altitude.Methods: A total of 856 young adult men were recruited. Before and after acute altitude exposure, the Athens Insomnia Scale score (AISS was used to evaluate the subjective sleep quality of subjects. AMS was assessed using the Lake Louise scoring system. Heart rate (HR and arterial oxygen saturation (SaO2 were measured.Results: Results showed that, at 500 m, AISS and insomnia prevalence were higher in older individuals. After acute exposure to altitude, the HR, AISS, and insomnia prevalence increased sharply, and the increase in older individuals was more marked. The opposite trend was observed for SaO2. At 3,700 m, the prevalence of AMS increased with age, as did severe AMS, and AMS symptoms (except gastrointestinal symptoms. Multivariate logistic regression analysis showed that age was a risk factor for AMS (adjusted odds ratio [OR] 1.07, 95% confidence interval [CI] 1.01–1.13, P<0.05, as well as AISS (adjusted OR 1.39, 95% CI 1.28–1.51, P<0.001.Conclusion: The present study is the first to demonstrate that older age is an independent risk factor for AMS upon rapid ascent to high altitude among young adult Chinese men, and pre-existing poor subjective sleep quality may be a contributor to increased AMS prevalence in older subjects. Keywords: acute mountain sickness, age, Athens Insomnia Scale, rapid ascent, sleep

  2. Toxicity evaluation of boron nitride nanospheres and water-soluble boron nitride in Caenorhabditis elegans

    Directory of Open Access Journals (Sweden)

    Wang N

    2017-08-01

    Full Text Available Ning Wang,1 Hui Wang,2 Chengchun Tang,3 Shijun Lei,1 Wanqing Shen,1 Cong Wang,1 Guobin Wang,4 Zheng Wang,1,4 Lin Wang1,5 1Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, 2Department of Medical Genetics, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 3Boron Nitride Research Center, School of Materials Science and Engineering, Hebei University of Technology, Tianjin, 4Department of Gastrointestinal Surgery, 5Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Abstract: Boron nitride (BN nanomaterials have been increasingly explored for potential biological applications. However, their toxicity remains poorly understood. Using Caenorhabditis elegans as a whole-animal model for toxicity analysis of two representative types of BN nanomaterials – BN nanospheres (BNNSs and highly water-soluble BN nanomaterial (named BN-800-2 – we found that BNNSs overall toxicity was less than soluble BN-800-2 with irregular shapes. The concentration thresholds for BNNSs and BN-800-2 were 100 µg·mL-1 and 10 µg·mL-1, respectively. Above this concentration, both delayed growth, decreased life span, reduced progeny, retarded locomotion behavior, and changed the expression of phenotype-related genes to various extents. BNNSs and BN-800-2 increased oxidative stress levels in C. elegans by promoting reactive oxygen species production. Our results further showed that oxidative stress response and MAPK signaling-related genes, such as GAS1, SOD2, SOD3, MEK1, and PMK1, might be key factors for reactive oxygen species production and toxic responses to BNNSs and BN-800-2 exposure. Together, our results suggest that when concentrations are lower than 10 µg·mL-1, BNNSs are more biocompatible than BN-800-2 and are potentially biocompatible material. Keywords: boron nitride nanomaterials, Caenorhabditis elegans, nanotoxicology

  3. Nimotuzumab combined with radiotherapy for esophageal cancer: preliminary study of a Phase II clinical trial

    Directory of Open Access Journals (Sweden)

    Liang J

    2013-11-01

    Full Text Available Jun Liang,1 Mingyan E,2 Gang Wu,3 Lujun Zhao,4 Xia Li,5 Xia Xiu,6 Ning Li,1 Bo Chen,1 Zhouguang Hui,1 Jima Lv,1 Hui Fang,1 Yu Tang,1 Nan Bi,1 Wenqing Wang,1 Yirui Zhai,1 Tao Li,1 Dongfu Chen,1 Shuangmei Zou,7 Ning Lu,7 Rolando Perez-Rodríguez,8 Junqi Zheng,9 Luhua Wang11Department of Radiotherapy, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China; 2Department of Radiotherapy, Cancer Hospital of Harbin Medical University, Harbin, People's Republic of China; 3Department of Radiotherapy, Tongji Cancer Center Hospital, Wuhan, People's Republic of China; 4Department of Radiotherapy, Cancer Hospital of Tianjin Medical University, Tianjin, People's Republic of China; 5Department of Radiotherapy, LiaoNing Province Cancer Hospital, Shenyang, People's Republic of China; 6Department of Radiotherapy, Beijing Hospital, Beijing, People's Republic of China; 7Department of Pathology, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China; 8Center of Molecular Immunology, Havana, Cuba; 9School of Medicine, Tongji University, Shanghai, People's Republic of ChinaObjective: To determine the safety and therapeutic effects of nimotuzumab (h-R3 combined with radiotherapy in esophageal cancer.Methods: This Phase II clinical trial involved 42 patients with stage II (inoperable or refused surgery to stage IV (supraclavicular lymph node metastasis only esophageal cancers treated between November 2008 and July 2010. All patients had squamous cell carcinomas, and all received three-dimensional conformal radiotherapy and 200 mg nimotuzumab per week during radiotherapy.Results: There were 9, 25, and 8 patients with stage II, III and IV disease, respectively. All except two patients received 50–70 Gy radiation; 37 patients (88.1% received more than five nimotuzumab doses. Grade III toxicities (21.4% of all adverse events included esophagitis and gastrointestinal, dermatological and hematological

  4. Suigu lapsed poseerivad Inglismaa pereajakirjas / Veste Roosaar

    Index Scriptorium Estoniae

    Roosaar, Veste, 1960-

    2009-01-01

    Inglismaal Bornemouthi kunstiinstituudi lõpetanud fotograaf Katrina Tang tegi koos stilisti Natalie Chestermaniga pildiseeria "Tagasi kooli", mis tutvustas Inglismaa moodi eesti laste seljas. Tang pildistas Suigu lapsi, kellede pilte võib näha Inglismaa ajakirja Junior septembrinumbris

  5. Journal of Chemical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Chemical Sciences. Ying Tang. Articles written in Journal of Chemical Sciences. Volume 125 Issue 2 March 2013 pp 313-320. Modified calcium oxide as stable solid base catalyst for Aldol condensation reaction · Ying Tang Jingfang Xu Xuefan Gu · More Details Abstract Fulltext PDF. A highly ...

  6. Dagligliv i 1800-tallets Jylland

    DEFF Research Database (Denmark)

    Christiansen, Palle Ove

    2014-01-01

    Genudgivelse af ældre artikler af folkloristen Evald Tang Kristensen med introduktioner til hver artikel samt større indledning til bogen.......Genudgivelse af ældre artikler af folkloristen Evald Tang Kristensen med introduktioner til hver artikel samt større indledning til bogen....

  7. Cloning and molecular characterization of a copper chaperone gene ...

    African Journals Online (AJOL)

    Administrator

    2011-06-20

    Jun 20, 2011 ... Available online at http://www.academicjournals.org/AJB. DOI: 10.5897/AJB10. ... Rubber tree is currently propagated by grafting clonal ... Total RNA was extracted according to Tang's method (Tang et al.,. 2007). The quality ...

  8. The state civil responsibility for the concessionaire acts concerning to the environmental damages caused by the petroleum and natural gas economical exploration; A responsabilidade civil do estado pelos atos do concessionario no que tange aos danos ambientais causados pela exploracao economica do petroleo e gas natural

    Energy Technology Data Exchange (ETDEWEB)

    Marinho, Karoline Lins Camara [Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN (Brazil)

    2004-07-01

    By means of the concession institute, the administration provides, indirectly, its originary functions gestion, acting and stimulating the development of the private activity with the exclusive attribution to the particulars, of rights and faculties, having always as a bigger aim the public interest. That being so, with the advent of the Amendment number 9 of the 1988 Federal Constitution, the State went by realizing concessions in the petroleum and natural gas field, allowing the market aperture, which was, before the amendment, monopolized by a state company - PETROBRAS. However, in spite of concede the exploration, production and transport rights of this product, the State keep itself playing the role of the collective interest prosecutor, and in such case, must be responsible for the damages that perhaps its concessionaires cause. The present research is purposed to study specifically the environment damages caused by the petroleum industry concessionaires, in what concerns to the state civil responsibility, using the many interpretative methods of the Law, like the historical, the systematic and the teleological, in the scope of contribute for a juridic culture each time stronger in the defense of the diffuse rights, in specific the environment rights. (author)

  9. Putini sõprade käes on Riia ja peagi võibolla ka Seim / Otto Ozols ; intervjueerinud Taavi Minnik

    Index Scriptorium Estoniae

    Ozols, Otto

    2016-01-01

    Intervjuu Läti kirjaniku ja publitsisti Otto Ozolsiga lõunanaabrite juures toimuvast ning sellest, kuidas on viimaste aastate arengud Euroopas ja Venemaal puudutanud Läti poliitikat ning ühiskonda

  10. Moraalset lõivu maksmata on raske äri ajada / Priit Jõgi

    Index Scriptorium Estoniae

    Jõgi, Priit, 1970-

    2003-01-01

    Autor arutleb ettevõtjate ning poliitikute sidemete üle Eestis ning leiab, et parteide toetamisele ettevõtete poolt tuleks seada teatavad piirangud, parteide rahastamise keelamise asemel tuleks see muuta läbipaistvamaks.

  11. Märketeatesuusatamine uues kuues Mammastes / Nikolai Järveoja

    Index Scriptorium Estoniae

    Järveoja, Nikolai, 1950-

    2010-01-01

    Märkeorienteerumise ajaloost ning 27. veebruaril 2010 Mammastes uute reeglite alusel toimunud Eesti meistrivõistlustest suusaorienteerumise märketeates. Ajalugu meenutab Arne Kivistik ning võistlust kommenteerivad Tõnis Erm ja Raul Kudre

  12. Taaskasutusest armastusega / Tiiu Suvi

    Index Scriptorium Estoniae

    Suvi, Tiiu

    2006-01-01

    Tuuliki Peili loomingulistest rõivastest, mis kannavad silti "Humana Disain" ning on valmistatud peamiselt second-hand materjalist ja Tallinna Taaskasutuskeskuse tekstiilikojast ning selle meistri Pille Kelleri tegemistest

  13. Inglismaa firma müüb brittidele Eestis asuvat kinnisvara / Raigo Neudorf

    Index Scriptorium Estoniae

    Neudorf, Raigo

    2005-01-01

    Ilmunud ka: Infopress 8. juuli lk. 34. Suurbritannia kinnisvarafirma Churchill Properties tegevusest Eestis ning Eesti kinnisvaraettevõtte OÜ Manutent tegevusest Hispaanias. Eesti ja Hispaania kinnisvaraturust ning hindadest. Lisa: Kalleim korter maksab neli miljonit

  14. Igal mõisal on oma lugu / Mari-Ann Remmel

    Index Scriptorium Estoniae

    Remmel, Mari-Ann

    2008-01-01

    Kirjastuselt "Tänapäev" ilmus raamat "Mõisalegendid. Harjumaa", koostaja Mari-Ann Remmel, kujundaja Angelika Schneider. Kogumik sisaldab ka ajaloolist ning genealoogilist teavet mõisahoonete ning -omanike kohta

  15. Mõista mitte hukka mõista / Mario Sootna

    Index Scriptorium Estoniae

    Sootna, Mario, 1962-

    2004-01-01

    Rahvaliidu põllumajandusministri Tiit Tammsaare tagasiastumisest seoses teraviljavarude vargusega ning rünnakutest siseminister Margus Leivo vastu julgeolekuvarude varguse avastamise ning tema poja narkoprobleemide tõttu

  16. Edgar Morin maailmaühiskonna problemaatikast / Maiki Voore

    Index Scriptorium Estoniae

    Voore, Maiki, 1983-

    2008-01-01

    Rahvusvahelisest konverentsist "Kultuuriproblemaatika keelte ja kultuuride õpetamisel ning õppimisel ning õppimisel ülemaailmastumise ja individiualiseerimise ristumisteel: interdistsiplinaarne käsitlus", mille üheks peaesinejaks oli prantsuse filoloog ja antropoloog emeriitprofessor Edgar Morin

  17. Tee selgeks, mis sind segab / Hede Kerstin Luik ; interv. Aavo Kokk

    Index Scriptorium Estoniae

    Luik, Hede Kerstin

    2003-01-01

    Statoili turundusjuht Hede Kerstin Luik kirjeldab muutusi, mida Shelli bensiinijaamade ostmine ettevõttele ning selle töötajatele kaasa tõi ning kuidas pingelisel ajal tööstressiga võideldi. Kommenteerib Mihkel Reinsalu.

  18. Balti riikide raamatukoguhoidjate avaldus pagulastele pakutavate raamatukoguteenuste asjus / inglise keelest tõlkinud Tiina Büttner

    Index Scriptorium Estoniae

    2015-01-01

    Avalduse koostasid Läti, Eesti ja Leedu raamatukoguhoidjate ühingud ning selle võtsid ühehäälselt vastu Balti raamatukoguhoidjate 10. kongressi ning Läti raamatukoguhoidjate 17. konverentsi osalejad Riias 13. oktoobril 2015

  19. Kuidas püüda hetke / Taimi Elenurm

    Index Scriptorium Estoniae

    Elenurm, Taimi

    2009-01-01

    Olevikule keskendumise positiivsest mõjust eluga edasi liikumisel ning vabanemaks kammitsevatest hinnangutest, samuti inglise psühholoogide Gill Hassoni ja Helena Pozniaki poolt kirjeldatud kuuest sammust, mis aitavad leida kontakti olevikuga ning olla õnnelikud

  20. Protecting the rights of patients in psychiatric settings : a comparison of the work of the Mental Health Act Commission with the CQC / Judy Laing

    Index Scriptorium Estoniae

    Laing, Judy

    2014-01-01

    Tervishoiu kvaliteedi komisjoni (Care Quality Commission) ning vaimse tervishoiu komisjoni (Mental Health Act Commission) töö võrdlusest psühhiaatriliste patsientidega ning vastavatest regulatsioonidest

  1. Elektrijaamade struktuur Eesti energiasüsteemis / Heiki Tammoja

    Index Scriptorium Estoniae

    Tammoja, Heiki, 1947-

    2007-01-01

    Eesti elektrijaamade liigitusest primaarenergia kasutamise struktuuri ning kasutatava tehnoloogia järgi. Elektrijaamade optimaalsest struktuurist ning elektroenergeetika arengukavade koostamisest MARKAL (market allocation) mudeli järgi. Lisatud statistilised joonised ja diagrammid

  2. LEADER-programm toob Jõgevamaale miljoneid kroone / Ardi Kivimets

    Index Scriptorium Estoniae

    Kivimets, Ardi, 1947-

    2007-01-01

    Jõgevamaa Koostöökoja juhatus ja liikmed ning külade esindajad arutasid LEADER-meetme rakendamist maakonnas ning tegevuspiirkonna arengustrateegia koostamist. Oma kogemusi jagasid Soome Turu piirkonna Varsinais-Suomen LEADER-tegevusgrupi esindajad

  3. Ajamere lainetes / Jana Savi

    Index Scriptorium Estoniae

    Savi, Jana

    2012-01-01

    Psühholoogilisest aja käsitlusest - minevik, olevik, tulevik ning teraapiatest (elu)probleemide lahendamiseks. Hetkes elamisest ning neljandast mõõtmest (aeg ja ruum), aegruumi mustritest ja maiade kalendrist

  4. Kaitseliidu kool sai hinnalise kingituse / Kaire Kozlov

    Index Scriptorium Estoniae

    Kozlov, Kaire

    2006-01-01

    Oma viiendat tegutsemisaastat tähistav Kaitseliidu kool sai sünnipäevakingiks kuueteistkümnest sülearvutist ning lisaseadmetest koosneva arvutiklassi, kinkijateks osaühing SmartLink ning Riigikaitse Edendamise Sihtasutus

  5. Kolmkümmend aastat eestikeelset kirikut Washingtonis / Johannes Pedak

    Index Scriptorium Estoniae

    Pedak, Johannes, 1908-2003

    1980-01-01

    USAs, Washingtonis 31. 10. 1949 peetud esimesest eestikeelsest jumalateenistusest. Eripihtkonna kujunemisest ning Baltimore kogudusega liitumisest. EELK Balto-Washingtoni koguduse kujunemisest ning tegevusest 30 aasta jooksul. Kogudusega seotud isikutest

  6. Tondi Sõjakoolist laia maailma / Piret Kuusik ; juhendajad Merike Jürjo, Reet Viikholm

    Index Scriptorium Estoniae

    Kuusik, Piret

    2011-01-01

    Uurimistöö käsitleb Tondi Sõjakooliga seonduvat ning tolleaegseid etiketi- ja käitumisnorme. Töö annab ülevaate aspirant Arvid Tarsi ning temaga koos õppinud nelja kursuslase isikutest ja nende saatusest

  7. Instrument või museaal? / Risto Lehiste

    Index Scriptorium Estoniae

    Lehiste, Risto

    2010-01-01

    Muuseumide ning ühiskonna suhtumisest vanadesse muusikainstrumentidesse. Seoses Eesti Teatri- ja Muusikamuuseumis 30. septembril 2010 toimunud seminariga "Instrument või museaal? Ajalooliste pillide restaureerimine ning kasutamine muuseumis"

  8. Püsiva tegevuskoha mõiste rahvusvahelistes maksulepingutes ja Eesti tulumaksuseaduses / Aare Kurist

    Index Scriptorium Estoniae

    Kurist, Aare, 1974-

    1998-01-01

    Püsiva tegevuskoha mõistest vastavalt OECD 1992. a. tulu ja kapitali maksustamise mudelkonventsioonile ning selle alusel riikide vahel sõlmitud topeltmaksustamise vältimise ning maksudest hoidumise tõkestamise lepingutele

  9. Kambakas Taistole / Janar Filippov

    Index Scriptorium Estoniae

    Filippov, Janar, 1976-

    2003-01-01

    Autoettevõtete Liit ning 19 bussifirma juhti esitasid siseminister Margus Leivole ning majandus- ja kommunikatsiooniminister Meelis Atonenile pöördumise bussiettevõtte Taisto kohta. Küsimustele vastab Tajo Saluste

  10. Voters shrug off upcoming EP ballot / Aleksei Gunter

    Index Scriptorium Estoniae

    Gunter, Aleksei, 1979-

    2004-01-01

    Emor'i uuring näitab, et europarlamendi valimistel osaleb kõigest 33 protsenti valijatest ning valik toimub isikute, mitte erakondade järgi. Soosikuteks ennustatakse Toomas Hendrik Ilvest ning Reformierakonda. Tabel

  11. Telekommunikatsiooniteenuseid pakkuvas ettevõttes integreeritud kvaliteedi- ja keskkonnajuhtimissüsteemi rakendamisest / Laur Lemendik, Kalle Paju

    Index Scriptorium Estoniae

    Lemendik, Laur

    2005-01-01

    Ülevaade standardites ISO 9001:2000 ning ISO 14001:2004 toodud nõuetele vastava integreeritud kvaliteedi- ja keskkonnajuhtimissüsteemi ülesehitusest ning kasutuselevõtmisest telekommunikatsiooniteenuseid osutavas ettevõttes. Skeemid

  12. Hispaania kurk, made in Poland / Gunnel Koba

    Index Scriptorium Estoniae

    Koba, Gunnel

    2009-01-01

    Taimekaitse vahendite kahjulikust mõjust inimese tervisele ning Veterinaar- ja toiduameti andmed Eestis aastail 1998-2007 uuritud puu-, juur- ning aedviljade taimekaitsevahendite ja pestitsiidijääkide seire proovidest

  13. Kultuuriajakirjad sotsioloogi pilguga / Marju Lauristin

    Index Scriptorium Estoniae

    Lauristin, Marju, 1940-

    2008-01-01

    Vaadeldakse "Keele ja Kirjanduse" ning teiste kultuuriajakirjade lugejate arvu muutumist 1950. aastatest kuni tänapäevani, ning mõtiskletakse lugejaskonna suurendamise võimalikkuse ja/või vajalikkuse üle

  14. Walt Disney uus noorus / Silvia Viidik

    Index Scriptorium Estoniae

    Viidik, Silvia, 1972-

    2010-01-01

    Meelelahutuskompanii Walt Disney müüs filmistuudio Miramax ning ostis muusikamänge tootva ettevõtte Tapulous, mille loodud rakendusi kasutab iPhone, ning Facebooki jaoks mänge loova ettevõtte Playdom

  15. Kinnisvaraarendusprojekti hindamine / Signe Liiv

    Index Scriptorium Estoniae

    Liiv, Signe

    2002-01-01

    Kasut. kirj. lk. 36. - Kokkuvõte ingl. k. lk. 36-37. Ülevaade kinnisvaraarendusprojekti hindamise eripärasusest, põhimõtetest ning teooria ja praktika vahelistest seostest ning vastuoludest Eesti kinnisvaraarenduses

  16. Eesti talumaja moderniseerimine 1850.-1920. aastail : elamiskultuur ja hügieen / Heiki Pärdi ; resümee tlk. Tiina Mällo

    Index Scriptorium Estoniae

    Pärdi, Heiki, 1951-

    2007-01-01

    Eesti taluelamu arenemisest traditsioonilisest rehielamust moodsaks elamuks. Elamu arengu osast kollektivistliku eluviisi muutumisel individualistlikuks koos talurahva elulaadi ja mõtteviisi muutumisega ning majast kui omanike jõukuse ning ühiskondlikku seisundi peegeldajast

  17. Polügraafiatesti abil saadud andmete usaldusväärsuse võrdlemine muude tõendite usaldusväärsusega : [bakalaureusetöö] / Ilona Marken-Kruusmägi ; Tartu Ülikool, õigusteaduskond Tallinnas ; juhendaja: Talis Bachmann

    Index Scriptorium Estoniae

    Marken-Kruusmägi, Ilona, 1988-

    2013-01-01

    Polügraafitesti kirjeldus ning selle abil saadava informatsiooni usaldusväärsuse hindamisest, teiste tõendite tutvustusest ning nende usaldusväärsuse hindamisest, võrdlevast hinnangust, tuleviku suundumistest

  18. Keda peaks uskuma investor? / Kaire Uusen

    Index Scriptorium Estoniae

    Uusen, Kaire

    2003-01-01

    Ilmunud ka: Spekter (vene k.) nr. 2, lk. 14-15. Autor võrdleb analüütikuid ning ettevõtete juhte investeerimisinformatsiooni allikana ning selgitab, millest tulenevad erinevused analüüsides ja hinnangutes

  19. I kvartalis vähenes turism Eestis ja kõigis lähiriikides / Piret Kallas

    Index Scriptorium Estoniae

    Kallas, Piret

    2009-01-01

    Eesti majutusettevõtetes I kvartalis 2006-2009 majutatud turistid ja nende ööbimised ning turistide ööbimiste arvu muutus 2009 I kvartalis võrreldes 2008. aasta I kvartaliga Eestis, Põhjamaades ning Baltimaades.

  20. Laimre ja "mina" : Marco Laimre isiknäitus "Küsimused ja vastused" Rotermanni Soolalaos = Laimre and "me" : Marco Laimre solo exhibition "Questions and answers" at the Rotermann salt storage / Anders Härm

    Index Scriptorium Estoniae

    Härm, Anders, 1977-

    2009-01-01

    Marko Laimre unikaalsest ja isikupärasest maailmanägemise ning -käsitlemise viisist, tema raskesti defineeritavast ja irriteerivast loomingust ning isiknäitusest "Küsimused ja vastused" 2004. aastal

  1. Pro god uhhodjashtshii mõ jeshtsho mozhem skazat "neplohhoi". Kak nazovut god sledujushtshii?

    Index Scriptorium Estoniae

    2008-01-01

    Ida-Virumaa suuremate omavalitsuste juhid Jevgeni Solovjov, Niina Neglasson, Jelena Korshunova ja Mihhail Stalnuhhin ning Ida-Viru maavanem Riho Breivel teevad kokkuvõtteid mööduvast aastast ning heidavad pilgu algavasse aastasse

  2. Rahvusvahelise lapsendamise korraldamise õiguslikke probleeme Eestis : [bakalaureusetöö] / Laine Valkama ; Tartu Ülikool, õigusteaduskond ; juhendaja: Edgar Salumaa

    Index Scriptorium Estoniae

    Valkama, Laine

    1993-01-01

    Lapsendamise eesmärk ja tingimused, rahvusvahelise lapsendamise õiguslik reguleerimine, rahvusvahelise lapsendamise organid ja lapsendamisteenistus ning rahvusvahelise lapsendamise etapid Soomes. lapsendamise õiguslikud tagajärjed ning rahvusvahelise lapsendamise korraldus ja tingimused Eestis

  3. Baltic leaders who returned from West to East

    Index Scriptorium Estoniae

    2006-01-01

    Artiklis tutvustatakse kolme Balti riigi presidentide sarnast minevikku eksiilis ning nenditakse, et varasem demokraatlikus riigis elamise kogemus on kindlasti kaasa aidanud Eesti, Läti ja Leedu majanduslikule ning välispoliitilisele edule

  4. Tip Tip Tap / Rasmus Varunov ; intervjueeris Käthlin Mikiver

    Index Scriptorium Estoniae

    Varunov, Rasmus

    2007-01-01

    Laste mänguväljakute atraktsioonidest, nende turvalisusest. Vestlus laste mänguväljakute atraktsioone ja noortele ning täiskasvanutele spordi- ning puhkeväljakuid tootva o.-ü. Tiptiptap tegevjuhiga

  5. Veski - Peegli liinilt / Ellen Uuspõld ; vestelnud Maarja Lõhmus

    Index Scriptorium Estoniae

    Uuspõld, Ellen, 1927-

    2014-01-01

    Juhan Peegel eesti keele kateedri aspirandi ja õppejõuna ning ajaloo-keeleteaduskonna dekaanina. Ka Ellen Uuspõllu õpingutest Tartu Riikliku Ülikooli kaugõppes alates 1945 ning tööst eesti keele kateedris

  6. Külalised 11 riigist tutvusid Eesti toiduturismi võimalustega / Tea Lajal

    Index Scriptorium Estoniae

    Lajal, Tea, 1967-

    2012-01-01

    Kokkuvõte Tartus 2.-9.juulini toimunud Euroopa veini- ja gastronoomia ühingute kokkusaamisest ning 7. juulil Vanemuise Kontserdimajas peetud CEUCO X Euroopa kongressist teemal "Toit on väärtuste kandja" ning gurmeemessist

  7. Media planning at Lillehammer / Oksana Kostina

    Index Scriptorium Estoniae

    Kostina, Oksana

    2005-01-01

    Postimees organiseeris oma reklaamimeeskonnale ning partneritele kümnest reklaamiagentuurist kolmepäevase suusareisi Norrasse, et lähendada inimesi üksteisele ning samas tutvustada sealset meediamaastikku

  8. Hundisilma Edgar, parajalt paks ja parimais aastais / Edgar Savisaar ; interv. Kaire-Külli Kuldbek

    Index Scriptorium Estoniae

    Savisaar, Edgar, 1950-

    2006-01-01

    Eesti Keskerakonna esimees, majandus- ja kommunikatsiooniminister Edgar Savisaar iseloomustab Vilja Savisaart abikaasa ja poliitikuna ning vastab küsimustele, mis puudutavad tema sidemeid usuga, pereelu ning võimalikku kandideerimist presidendiks

  9. Saurix Petroleum valitseb Loksat / Virkko Lepassalu

    Index Scriptorium Estoniae

    Lepassalu, Virkko, 1971-

    2003-01-01

    Kütusefirma Saurix Petroleumiga seotud ettevõtted teenivad Loksa linna soojamajanduselt ning elektrimüügilt suuri kasumeid ning on sundinud linnavalitsust enda eest ka pangavõlga maksma. Kommenteerib Mihkel Tiks

  10. Ja ne prosto obespokojen. Ja zol / Edward Lukas

    Index Scriptorium Estoniae

    Lukas, Edward

    2007-01-01

    Autor kritiseerib Eesti valitsuse otsust teisaldada pronkssõdur Tõnismäelt ning sellele järgnenud vandaalitsemist, Venemaa käitumist Eesti Moskva suursaatkonnaga ning Euroopa Liidu, NATO ja G-7 riikide mitteadekvaatset reageeringut sellele

  11. Aktsiasoovitus: Tarkvaratootja GigaMedia (GIGM) / Joel Kukemelk

    Index Scriptorium Estoniae

    Kukemelk, Joel

    2009-01-01

    Tarkvaralahenduste väljatöötamise ja nende litsentseerimisega ning Euroopa suuruselt neljandat online-mänguportaali Everest Poker omavasse ettevõtte GigaMedia (GIGM) aktsiatesse investeerimise ohtudest ning positiivsetest teguritest

  12. Avaroni kinnisvaraäri ajab ekspartner koos Kogeri & Partneritega / Kaisa Tahlfeld

    Index Scriptorium Estoniae

    Tahlfeld, Kaisa

    2008-01-01

    Avaron võttis vastu otsuse kinnisvarainvesteeringute ärist väljuda ja keskenduda aktsiafondide juhtimisele ning müüs kogu oma 60% osaluse Avaron Properties Koger & Partneritele ning endisele partnerile Aadu Ojale

  13. Õnnestumised saavad alguse teadmistest / Mihkel Kangur

    Index Scriptorium Estoniae

    Kangur, Mihkel

    2012-01-01

    Edu saavutamisest sporthobuste tõuaretuses Itaalia arhitekti ja riigiametniku ning Donatello hobusekasvatuse looja Federico Tesio ning Belgia veterinaari ja hobusekasvataja Joris de Brabander'i töö näitel

  14. Raudtee erastamine jõudis eile juba eelläbirääkimisteni / Erkki Erilaid

    Index Scriptorium Estoniae

    Erilaid, Erkki

    2000-01-01

    Baltic Rail Service, Rail Estonia ning Raudtee Erastamise Rahva AS koos Rootsi riigiraudtee SJ ja Suurbritannia infrastruktuuriettevõtte Sercoga esitasid erastamisagentuurile detailse ärikava koos hinna, investeeringute ning tehnilise ja finantsplaaniga

  15. Kurjade bakterite kõrvalmõju / Villu Zirnask

    Index Scriptorium Estoniae

    Zirnask, Villu, 1966-

    2012-01-01

    Alessandra Fogli Minnesota ülikoolist ning Laura Veldkamp Sterni ärikoolist kirjeldasid oma uuringus "Germs, social networks and growth" inimkontakti kaudu levivate haiguste esinemissageduse abil ühiskonna sotsiaalset struktuuri ning selle seost tehnoloogiate levimisega

  16. Grilli & tšilli, lõket & lõbu / Liia Merino & Ants Uustalu

    Index Scriptorium Estoniae

    Maerino, Liia

    2012-01-01

    Kokk Rain Käärst õpetab, milliseid tooteid ja kuidas tervislikult grillida ning mis on barbeque ja grilli erinevus. Ants Uustalu meenutab Eesti toidutraitsiooni paremaid maitseid ning nende valmistamise viise lõkkel ja suitsuga

  17. WHO uuring: vaesed kulutavad enim ravimitele, jõukad hambaravile / Jarno Habicht ; intervjueerinud Liina Ristoja

    Index Scriptorium Estoniae

    Habicht, Jarno, 1976-

    2010-01-01

    Maailma Terviseorganisatsiooni Eesti esinduse juht räägib Eesti inimeste kulutustest ravimitele ning tervishoiuteenustele, Eesti tervisesüsteemi arengust, tervishoiuteenuste kättesaadavusest ja sissetulekute ning tervishoiuteenuste vahelisest suhest teistes Euroopa Liidu riikides

  18. Eesti kool ja õpetaja rahvusvahelises haridusvõrdluses (EKORA) / Anu Toots

    Index Scriptorium Estoniae

    Toots, Anu, 1959-

    2014-01-01

    Ülevaade Eduko programmi finantseeritud projektist, mille eesmärk oli analüüsida, kuivõrd leiavad Eestile iseloomulikud haridusprobleemid kajastamist teiste riikide ja OECD ning EL poliitikadokumentides, ning milliseid meetmeid kasutatakse nende lahendamiseks

  19. The criminal repression of racist rhetoric, racist crimes and race discrimination – The Greek example: towards an effective protection of human dignity? / Maria Kaiafa-Gbandi

    Index Scriptorium Estoniae

    Kaiafa-Gbandi, Maria

    2017-01-01

    Küsimusest kuidas rassistlike kuritegude ja rassilise diskrimineerimisega seotud probleeme käsitletakse rahvusvahelises dokumentides, EL õigusaktides ning ÜRO ja Euroopa Nõukogu konventsioonides ning Kreekas

  20. Kogeja vormistamine eesti keeles : nihkeid SAE perifeerias / Mati Erelt, Helle Metslang

    Index Scriptorium Estoniae

    Erelt, Mati, 1941-

    2008-01-01

    Artiklis vaadeldakse kogeja vormistamist ning alternatiivsete mallide kasutust ajakirjanduskeeles ajavahemikul 1995-2005 eesmärgiga välja selgitada toimunud muutused ning nende põhjused. SAE - Euroopa keskmine standard