Our Man in Tallinn / Martin Anderson

Index Scriptorium Estoniae

Anderson, Martin

1997-01-01

Muljeid kontserdist "Warner Classics Gala" "Estonia" kontserdisaalis, kus E. Mägi, E.-S. Tüüri, V. Tormise, U. Sisaski jt. loomingut esitasid "Camerata Tallinn", NYYD Ensemble, RAM, pianist Lauri Väinmaa

Technical Note: Validation of Odin/SMR limb observations of ozone, comparisons with OSIRIS, POAM III, ground-based and balloon-borne instruments

Directory of Open Access Journals (Sweden)

F. Jégou

2008-06-01

Full Text Available The Odin satellite carries two instruments capable of determining stratospheric ozone profiles by limb sounding: the Sub-Millimetre Radiometer (SMR and the UV-visible spectrograph of the OSIRIS (Optical Spectrograph and InfraRed Imager System instrument. A large number of ozone profiles measurements were performed during six years from November 2001 to present. This ozone dataset is here used to make quantitative comparisons with satellite measurements in order to assess the quality of the Odin/SMR ozone measurements. In a first step, we compare Swedish SMR retrievals version 2.1, French SMR ozone retrievals version 222 (both from the 501.8 GHz band, and the OSIRIS retrievals version 3.0, with the operational version 4.0 ozone product from POAM III (Polar Ozone Atmospheric Measurement. In a second step, we refine the Odin/SMR validation by comparisons with ground-based instruments and balloon-borne observations. We use observations carried out within the framework of the Network for Detection of Atmospheric Composition Change (NDACC and balloon flight missions conducted by the Canadian Space Agency (CSA, the Laboratoire de Physique et de Chimie de l'{}Environnement (LPCE, Orléans, France, and the Service d'Aéronomie (SA, Paris, France. Coincidence criteria were 5° in latitude×10° in longitude, and 5 h in time in Odin/POAM III comparisons, 12 h in Odin/NDACC comparisons, and 72 h in Odin/balloons comparisons. An agreement is found with the POAM III experiment (10–60 km within −0.3±0.2 ppmv (bias±standard deviation for SMR (v222, v2.1 and within −0.5±0.2 ppmv for OSIRIS (v3.0. Odin ozone mixing ratio products are systematically slightly lower than the POAM III data and show an ozone maximum lower by 1–5 km in altitude. The comparisons with the NDACC data (10–34 km for ozonesonde, 10–50 km for lidar, 10–60 for microwave instruments yield a good agreement within −0.15±0.3 ppmv for the SMR data and −0.3±0.3 ppmv

Evaluation report of the Nordic emergency exercise Odin - November 26, 1993

International Nuclear Information System (INIS)

1994-01-01

An evaluation of the second phase, ODIN, of an emergency exercise which is related to the late phase of a hypothetical nuclear accident outside, but close to the Nordic countries. This phase, in contrast to the first one (NORA) during the course of which it was found that strong national ways of thinking unfluenced decision-making, was carried out on the same day in all five Nordic countries in order to enable contact between them. The main argument in favour of a coordinated approach in the intervention policy in this area is that it is likely that the public in each of these countries would be unable to understand or accept very different levels of ambition with regard to their protection. The main objective of ODIN was to add to the knowledge and increase the capability of those responsible in the Nordic countries for handling a situation of deposition following a nuclear accident to improve provisions for Nordic coordination of the overall decision-making and to reach a joint Nordic view of emergency response. The organization of the evaluation, the methodology of the exercise and the evaluation itself covering, amongst other aspects, responses by emergency organizations to the check lists on actions, the decision-making process, international communication, public information and technical facilities are dealt with. (AB)

Odin (ANKS1A is a Src family kinase target in colorectal cancer cells

Directory of Open Access Journals (Sweden)

Feller Stephan M

2008-10-01

Full Text Available Abstract Background Src family kinases (SFK are implicated in the development of some colorectal cancers (CRC. One SFK member, Lck, is not detectable in normal colonic epithelium, but becomes aberrantly expressed in a subset of CRCs. Although SFK have been extensively studied in fibroblasts and different types of immune cells, their physical and functional targets in many epithelial cancers remain poorly characterised. Results 64 CRC cell lines were tested for expression of Lck. SW620 CRC cells, which express high levels of Lck and also contain high basal levels of tyrosine phosphorylated (pY proteins, were then analysed to identify novel SFK targets. Since SH2 domains of SFK are known to often bind substrates after phosphorylation by the kinase domain, the LckSH2 was compared with 14 other SH2s for suitability as affinity chromatography reagent. Mass spectrometric analyses of LckSH2-purified pY proteins subsequently identified several proteins readily known as SFK kinase substrates, including cortactin, Tom1L1 (SRCASM, GIT1, vimentin and AFAP1L2 (XB130. Additional proteins previously reported as substrates of other tyrosine kinase were also detected, including the EGF and PDGF receptor target Odin. Odin was further analysed and found to contain substantially less pY upon inhibition of SFK activity in SW620 cells, indicating that it is a formerly unknown SFK target in CRC cells. Conclusion Rapid identification of known and novel SFK targets in CRC cells is feasible with SH2 domain affinity chromatography. The elucidation of new SFK targets like Odin in epithelial cancer cells is expected to lead to novel insight into cancer cell signalling mechanisms and may also serve to indicate new biomarkers for monitoring tumor cell responses to drug treatments.

Tallinn 1991. aastast alates / Kristjan Mändmaa

Index Scriptorium Estoniae

Mändmaa, Kristjan, 1973-

2006-01-01

9.-16. I Eesti Kunstiakadeemia graafilise disaini osakonnas Kaisa Lassinaro (Soome) ja Bart de Baetsi (Holland) juhendamisel toimunud workshop'ist. Tuli luua esikaas ajalehele The Tallinn'91 Onwards. Valminud esikaaned pandi kokku üheks ajaleheks ja trükiti ära

Raimo Pullati XX "Vana Tallinn" / Tõnis Liibek

Index Scriptorium Estoniae

Liibek, Tõnis

2009-01-01

Ilmus professor Raimo Pullati poolt välja antava linnaajalugu ja -kultuuri tutvustava sarja "Vana Tallinn" XX köide. Tšehhi Teaduste Akadeemia raamatukogus toimus Raimo Pullati poolt välja antud entsüklopeedilise suurteose "Johann Christoph Brotze. Estonica" esitlus

Tallinn Fashion Week algas moeillustraatorite näitusega

Index Scriptorium Estoniae

2011-01-01

Näitus "Uus Põhjamaade moeillustratsioon" Rotermanni kvartalis 18. sept.-ni. Osalejad Eestist, Soomest ja Rootsist loetletud. Näituse kujundaja Tuuli Aule. Väljapaneku loovjuhi Toomas Volkmanni selgitus. Tallinn Fashion Week'i põhiprogrammist

Tallinn 2011 panustab tänavu turismifirmadesse / Kärt Anvelt, Jan Jõgis-Laats ; kommenteerib Roman Geiser

Index Scriptorium Estoniae

Anvelt, Kärt, 1973-

2010-01-01

Reklaamibüroo Zavod juht Marek Reinaas annab hinnangu SA Tallinn 2011 eelarvekava turundusosale. Kommunikatsioonispetsialist Daniel Vaarik viitab võimalusele kasutada Tallinn 2011 tutvustamiseks sotsiaalvõrgustikke, nt. Facebooki ja Twitterit

Odin-OSIRIS stratospheric aerosol data product and SAGE III intercomparison

Directory of Open Access Journals (Sweden)

A. E. Bourassa

2012-01-01

Full Text Available The scattered sunlight measurements made by the Optical Spectrograph and InfraRed Imaging System (OSIRIS on the Odin spacecraft are used to retrieve vertical profiles of stratospheric aerosol extinction at 750 nm. The recently released OSIRIS Version 5 data product contains the first publicly released stratospheric aerosol extinction retrievals, and these are now available for the entire Odin mission, which extends from the present day back to launch in 2001. A proof-of-concept study for the retrieval of stratospheric aerosol extinction from limb scatter measurements was previously published and the Version 5 data product retrievals are based on this work, but incorporate several important improvements to the algorithm. One of the primary changes is the use of a new retrieval vector that greatly improves the sensitivity to aerosol scattering by incorporating a forward modeled calculation of the radiance from a Rayleigh atmosphere. Additional improvements include a coupled retrieval of the effective albedo, a new method for normalization of the retrieval vector to improve signal-to-noise, and the use of an initial guess that is representative of very low background aerosol loading conditions, which allows for maximal retrieval range. Furthermore, the Version 5 data set is compared to Stratospheric Aerosol and Gas Experiment (SAGE III 755 nm extinction profiles during the almost four years of mission overlap from 2002 to late 2005. The vertical structure in coincident profile measurements is well correlated and the statistics on a relatively large set of tight coincident measurements show agreement between the measurements from the two instruments to within approximately 10% throughout the 15 to 25 km altitude range, which covers the bulk of the stratospheric aerosol layer for the mid and high latitude cases studied here.

Tallinn makes most intellegent city list / Ella Karapetyan

Index Scriptorium Estoniae

Karapetyan, Ella

2010-01-01

Intelligent Community Forum (ICF) kuulutas välja 2010. aastal Smart21 nimekirja pääsenud kogukonnad. Tallinn asub nimekirjas 7. kohal. Nimekirja jõuavad suure majandusliku ja sotsiaalse arengu läbi teinud kogukonnad. 21. mail kuulutatakse välja võitnud kogukond

Multi-Ethnicity and Material Exchangesin Late Medieval Tallinn

DEFF Research Database (Denmark)

Naum, Magdalena

2014-01-01

his article examines the cultural and social dynamics of a multi-ethnic medieval town. Taking the lower town of Tallinn as a case study, this paper identifies the major urban ethnic groups living in the town and discusses their co-existence, self-definition, and processes of categorization...

A Comparison of Taste of Helsinki and Tallinn Restaurant Week : Possible Cooperation & Benefits

OpenAIRE

Harnova, Veronika

2015-01-01

The aim of this Bachelor’s Thesis is to analyse restaurant events happening in Helsinki and Tallinn, compare them and create a new event that joins both cities in cooperation. Two events were chosen, Taste of Helsinki and Tallinn Restaurant Week, as they have a common purpose and target market. The theoretical framework studies the strategies of event organising, the factors of consumer buying behaviour and the consumer buying decision process. The Twin-Capital project is examined...

Detergent zeolite complex "Ceosil", Tallinn, Estonia

OpenAIRE

Stanković Mirjana S.; Pezo Lato L.

2003-01-01

The IGPC Engineering Department, together with the "Birac", Zvornik Engineering Department designed basic projects for detergent zeolite production, using waste flotation sand and hydrates. Several projects were completed: technological, machine, electrical, automation. On the basis of these projects, production plant in Tallinn, Estonia was constructed, with a capacity of 100,000 t/y from 1989. to 1993. This plant became the biggest producer of detergent zeolite in the world.Several goals we...

ESADSE, Option Design: Workshop Tallinn For All

Index Scriptorium Estoniae

2011-01-01

Rahvusvahelisest koostööprojektist "Cities For All - Tallinn For All". Projekti viis läbi Eesti Disainerite Liit. Ilona Gurjanova organiseeritud töötubades osalesid ajavahemikus september 2010 - september 2011 järgmised kõrgkoolid: Eesti Kunstiakadeemia, Mainori Kõrgkool, Tartu Ülikooli Pärnu Kolledž, Aalto Ülikool (Soome), Saint-Étienne Higher School of Art and Design (Prantsusmaa)

Kas Tallinn vajab uut brändi? / Andreas Sepp

Index Scriptorium Estoniae

Sepp, Andreas

2010-01-01

Tallinnas viibinud saksa loomemajanduse õppejõudude Bernd Hartmanni ja Jan Runge sõnul on kultuuripealinna aasta hea võimalus linnakuvandi parandamiseks. Nende arvates võiks Tallinn kultuuripealinna raames anda noortele disaineritele ja filmitegijatele loomingu eksponeerimiseks piisavalt võimalusi ning keskenduda kohaliku kultuurielu parandamisele

Hoogsalt moodne Tallinn Fashion Week / Jaanika Terasmaa : intervjueerinud Annely Martin

Index Scriptorium Estoniae

Terasmaa, Jaanika

2010-01-01

Tallinn Fashion Week kestab 7. novembrini. Üks moenädala korraldajaid Jaanika Terasmaa, sellest, mida moenädal pakub tavainimesele ja kui oluline on selline ettevõtmine moeloojatele, moenädala eesmärgist

Tallinn 2011 ... mitte ainult koorikonkurss / Aivar Leštšinski

Index Scriptorium Estoniae

Leštšinski, Aivar, 1958-

2011-01-01

Festivali avapäeval esitletud CD-komplektist "Läbilõige eesti koorimuusikast" ja mõtteid, et riigitelevisioonis võik olla koorimuusikat puudutav saade ning koorifestivali "Tallinn 2011" tulemused

Madalmaade nukunäitlejate paremik hiilgas Tallinn Treffil / Tiiu Laks

Index Scriptorium Estoniae

Laks, Tiiu, 1984-

2010-01-01

5.-8. juunini 2010 toimuvast rahvusvahelisest festivalist Tallinn Treff. Hollandi trupi DudaPaiva lavastusest "Needus". Nukunäitleja Neville Tranteri (Austraalia-Holland) lavastusest "Punch ja Judy Afganistanis". Stef Vettersi (Belgia) etendusest "Tema kõrgeausus Ottfriedi tundmatu maailm"

Euroopa kultuuripealinn Tallinn 2011 paneb PÖFF-ile õla alla

Index Scriptorium Estoniae

2011-01-01

15. Pimedate Ööde Filmifestivali ja Euroopa Kultuuripealinna Tallinn 2011 koostöös alguse saanud noortele animavallas tegutsevatele professionaalidele mõeldud koolitussarjast AnimaCampus, rahvusvahelise filmituru Black Market ja programmi "60 sekundit üksindust aastal Null" toetamisest

The role of personality disorder in 'difficult to reach' patients with depression: Findings from the ODIN study

OpenAIRE

Kelly, Brendan D.; Casey, Patricia R.; Dunn, Graham; et al.

2007-01-01

Individuals with personality disorders (especially paranoid personality disorder) tend to be reluctant to engage in treatment. This paper aimed to elucidate the role of personality disorder in predicting engagement with psychological treatment for depression. The Outcomes of Depression International Network (ODIN) involves six urban and three rural study sites throughout Europe at which cases of depression were identified through a two-stage community survey. One patient in seven who was offe...

A stratospheric NO2 climatology from Odin/OSIRIS limb-scatter measurements

International Nuclear Information System (INIS)

Brohede, S.; Murtagh, D.; Berthet, G.; Haley, C.S.

2007-01-01

Since the late 1960s, it has been known that stratospheric nitrogen dioxide (NO 2 ) and ozone are closely coupled. However, stratospheric nitrogen chemistry is not yet fully understood, given the lack of observing systems that can provide both high vertical and temporal resolution measurements of NO 2 . Limb-scattering data from the optical spectrograph and infrared imager system (OSIRIS) aboard the Odin satellite was used in this study along with a photochemical box model to investigate stratospheric NO 2 climatology in terms of mean and standard deviation as a function of latitude, altitude, month and local solar time. The Odin orbit provided near global coverage around the equinoxes and hemispheric coverage elsewhere, due to lack of sunlight. The mean NO 2 field at a specific local solar time involved high concentrations in the polar summer, peaking at about 25 km, with a negative equatorward gradient. High levels between 40 to 50 degrees latitude at 30 km in the winter/spring hemisphere were also found, and were associated with the Noxon-cliff. The diurnal cycle revealed the lowest NO 2 concentrations just after sunrise and steep gradients at twilight. The 1σ standard deviation was around 20 per cent, except for winter and spring high latitudes, where values were above 50 per cent and stretched through the entire stratosphere. NO 2 concentrations were found to be log-normally distributed. Comparisons with the REPROBUS chemical transport model for climatology showed that the relative differences for the mean values were below 20 per cent and comparable to the estimated OSIRIS systematic uncertainty. The polar regions in winter/spring throughout the atmosphere and equatorial regions below 25 km were exceptions, where OSIRIS was higher by 40 per cent and more. It was concluded that further study is needed to determine if these discrepancies are due to limitations of the model. 47 refs., 10 figs., 1 appendix

Tallinn soovib linnahalli Ameerika investoritega ikka edasi minna / Raimo Poom

Index Scriptorium Estoniae

Poom, Raimo

2010-01-01

Tallinna linnavalitsus ootab enne otsustamist, kas pikendada Tallinna linnahalli arendamiseks sõlmitud eellepingut Ameerika ettevõttega Tallinn Entertainment LLC, Ameerika investorite delegatsiooni visiiti Tallinna. Rahandusminister Jürgen Ligi vastusest Tallinna abilinnapea Taavi Aasa kirjale, milles oli ettepanek kaaluda võimalust anda riigi garantii linnahalli arendamise projektile

Euroopa kultuuripealik 2011 (Tallinn) lõpuks leitud / Mikko Fritze ; interv. Kaarel Tarand

Index Scriptorium Estoniae

Fritze, Mikko, 1963-

2007-01-01

Tallinn on Euroopa 2011. a. kultuuripealinn. Intervjuu korraldava sihtasutuse tegevjuhi Mikko Fritzega. Tegevusprogrammist, ka infrastruktuuri projektidest (linnateater, Kultuurikatel, rannapromenaad, lauluväljak, linnahall) jm. SA bürool on kavatsus kolida Kultuurikatlasse

Arvustus : Vello Paatsi. Eesti talurahva loodusteadusliku maailmapildi kujunemine rahvakooli kaudu (1803-1918). - Tallinn : TPÜ Kirjastus, 2003. 206 lk. / Jaan-Mati Punning

Index Scriptorium Estoniae

Punning, Jaan-Mati, 1940-2009

2003-01-01

Rets. rmt. : Paatsi, Vello. Eesti talurahva loodusteadusliku maailmapildi kujunemine rahvakooli kaudu (1803-1918). - Tallinn : Tallinna Pedagoogikaülikooli kirjastus, 2003. - 206 lk. : ill. - (Tallinna Pedagoogikaülikool. Sotsiaalteaduste dissertatsioonid = Tallinn Pedagogical University. Dissertations on social sciences, 1406-4405 ; 5)

"Tallinn Jazz Weekend" tõi kultuuripealinna Euroopa jazzielu korraldajad / Marje Ingel, Joosep Sang

Index Scriptorium Estoniae

Ingel, Marje

2011-01-01

Jazziorganisatsioonist Europe Jazz Network ja selle aastakonverentsist Tallinnas ning J. Sang selle raames Von Krahli teatris toimunud Tallinn Jazz Weekendi eesti jazzmuusika showcase-festivalist lühidalt

Siim Nestor soovitab : Tallinn Doom Night vol.1. Odessa Pop / Siim Nestor

Index Scriptorium Estoniae

Nestor, Siim, 1974-

2006-01-01

Soome doom-metal ansambel Reverend Bizarre üritusel "Tallinn Doom Night vol.1" 8. dets. klubis Rockstar's. Indipoppi viljelev Rootsi duo My Darling Yoy! üritusel "Odessa Pop" 9. dets. Tallinnas klubis KuKu

[Karin Hallas. Das Tallinner Mietshaus. Vom Historismus bis zum Jugendstil] / Paul Kaegbein

Index Scriptorium Estoniae

Kaegbein, Paul

2006-01-01

Arvustus: Karin Hallas. Das Tallinner Mietshaus. Vom Historismus bis zum Jugendstil. In: Architektur und bildende Kunst im Baltikum um 1900. Frankfurt am Main, Berlin, Bern, Bruxelles, New York, Wien: Lang 1999. S. 173-192.

A rapid situation assessment of the market for surrogate and illegal alcohols in Tallinn, Estonia.

Science.gov (United States)

Pärna, Kersti; Lang, Katrin; Raju, Kadi; Väli, Marika; McKee, Martin

2007-01-01

To understand the phenomenon of consumption of surrogate and illegal alcohols in Tallinn, capital of Estonia. This study, conducted in Tallinn in May 2006, used rapid situation assessment. Interviews with key informants in relevant settings such as emergency departments of hospitals, accommodation for the homeless, police etc. (n = 22), with alcohol abusers (n = 33), natural observations of surrogate sale and consumption venues (n = 46), and tracking of trade data were carried out. Key informants confirmed that consumption of illegal and surrogate alcohols are widely used by alcohol abusers, a finding confirmed by the alcohol abusers. Availability of surrogates varied by area of the city, mainly sold from street kiosks. Illegally produced spirits were also easily available. Sales of surrogates appear to have increased in recent years. A range of alcohol-containing substances that appear to be easily available at low cost, and that have high concentration of ethanol or contaminants known to be toxic, were identified in Tallinn. Alcohol policies in Estonia should address the consumption and availability of these substances.

Reusable Electronics and Adaptable Communication as Implemented in the Odin Modular Robot

DEFF Research Database (Denmark)

Garcia, Ricardo Franco Mendoza; Lyder, Andreas; Christensen, David Johan

2009-01-01

This paper describes the electronics and communication system of Odin, a novel heterogeneous modular robot made of links and joints. The electronics is divided into two printed circuit boards: a General board with reusable components and a Specific board with non-reusable components. While...... electrical signals. The implementations of actuator and power links show that splitting the electronics into General and Specific boards allows rapid development of different types of modules, and an analysis of performance indicates that the communication system is simple, fast and flexible....... As the electronic design reuses approx. 50% of components between two different types of modules, we find it convenient for heterogeneous modular robots where production costs demand a small set of parts. In addition, as the features of the communication system are desirable in modular robots, we think...

Uhiuus orkester Tallinn Sinfonietta / Ivo Lille ja Risto Joost ; intervjueerinud Kristina Kõrver

Index Scriptorium Estoniae

Lille, Ivo, 1977-

2009-01-01

Kontserdiagentuurist HIMusic Agency ja Tallinn Sinfoniettast räägivad dirigent R. Joost ja I. Lille. Avakontserdist Vene Kultuurikeskuses, kus oli kavas Mozarti sümfooniad 1, 10 ja 40 ning kontsertaariad bulgaaria soprani Sonya Youncheva esituses

Tallinna Inglise kolledzhi spordihoone = The Tallinn English College's sports building

Index Scriptorium Estoniae

2008-01-01

Tallinna Inglise kolledzhi spordihoone (Estonia pst. 10, Tallinn) sisekujundusest. Arhitektid: Lembit-Kaur Stöör ja Margus Maiste (KOKO Arhitektid), sisearhitektid: Liisi Murula (Mari OÜ), Liis Lindvere ja Raili Paling, ornamentika: Martin Lazarev (KOKO Arhitektid). Sisearhitektidest, nende tähtsamad tööd. 5 korruse plaani, 2 värv. välis- ja 11 sisevaadet, fotod sisearhitektidest

Environmental innovation through transport policy. The implementation of the free fare policy on public transport in Tallinn, Estonia

Energy Technology Data Exchange (ETDEWEB)

Gabaldon-Estevan, D.

2016-07-01

Urban areas are of increasing relevance when it comes to sustainability: First, about half of the world’s population now lives in cities (increasing to 60% by 2030). Second, cities are nowadays responsible for levels of resource consumption and waste generation that are higher beyond their share on world population. Third, cities are more vulnerable to disruptive events that can lead to restrictions on the provision of resources and to changes on the environment caused by climate change. And fourth, because they concentrate key resources (political, social, cultural…), cities are seen as strategic scenarios where to experiment and develop solutions to cope with the prevailing sustainability challenges driven by the major social and environmental transformations. Urban agglomerations can be seen as complex innovation systems where human activities are shaped in order to transform societies towards sustainable development. For this paper, we focus on the case of an environmental innovation regarding transport policy, the implementation of the fare-free policy on public transport for all inhabitants of Tallinn, Estonia. Tallinn, with 414,000 inhabitants in 2015, is the capital of Estonia and the largest city in the country. Over the last two decades the share of public transport trips decreased dramatically. After a public opinion poll in 2012, in which over 75% of the participants voted for a fare-free public transportation system (FFPTS) in Tallinn, the new policy was implemented on 1st January 2013. From that date on inhabitants of Tallinn could use all public transport services (busses, trams, trolly-busses) operated by city-run operators for free. Later the fare-free system was implemented also on trains within Tallinn. In this paper we analyze the context, in which this policy was implemented, the main characteristics of its implementation and its actual situation. (Author)

[Lea Kõiv. Paul Johansen und das Stadtarchiv Reval/Tallinn] / Paul Kaegbein

Index Scriptorium Estoniae

Kaegbein, Paul

2008-01-01

Arvustus: Lea Kõiv. Paul Johansen und das Stadtarchiv Reval/Tallinn. - Nordosteuropa als Geschichtsregion. Helsinki : Aue-Stiftung; Lübeck : Schmict-Röhmild, 2006. Lk. 45-59. Artiklis on kasutatud seni avalikkusele vähetuntud materjale ja osaliselt käsitletud avalikke vaidlusi, kuhu olid segatud nii Paul Johansen kui järgmine linnaarhivaar Rudolf Kenkmaa

Comparison of CMAM simulations of carbon monoxide (CO, nitrous oxide (N2O, and methane (CH4 with observations from Odin/SMR, ACE-FTS, and Aura/MLS

Directory of Open Access Journals (Sweden)

B. Barret

2009-05-01

Full Text Available Simulations of CO, N2O and CH4 from a coupled chemistry-climate model (CMAM are compared with satellite measurements from Odin Sub-Millimeter Radiometer (Odin/SMR, Atmospheric Chemistry Experiment Fourier Transform Spectrometer (ACE-FTS, and Aura Microwave Limb Sounder (Aura/MLS. Pressure-latitude cross-sections and seasonal time series demonstrate that CMAM reproduces the observed global CO, N2O, and CH4 distributions quite well. Generally, excellent agreement with measurements is found between CO simulations and observations in the stratosphere and mesosphere. Differences between the simulations and the ACE-FTS observations are generally within 30%, and the differences between CMAM results and SMR and MLS observations are slightly larger. These differences are comparable with the difference between the instruments in the upper stratosphere and mesosphere. Comparisons of N2O show that CMAM results are usually within 15% of the measurements in the lower and middle stratosphere, and the observations are close to each other. However, the standard version of CMAM has a low N2O bias in the upper stratosphere. The CMAM CH4 distribution also reproduces the observations in the lower stratosphere, but has a similar but smaller negative bias in the upper stratosphere. The negative bias may be due to that the gravity drag is not fully resolved in the model. The simulated polar CO evolution in the Arctic and Antarctic agrees with the ACE and MLS observations. CO measurements from 2006 show evidence of enhanced descent of air from the mesosphere into the stratosphere in the Arctic after strong stratospheric sudden warmings (SSWs. CMAM also shows strong descent of air after SSWs. In the tropics, CMAM captures the annual oscillation in the lower stratosphere and the semiannual oscillations at the stratopause and mesopause seen in Aura/MLS CO and N2O observations and in Odin/SMR N2O observations. The Odin/SMR and Aura/MLS N2O observations also show a quasi

Programming Basics for Beginners. Experience of the Institute of Informatics at Tallinn University of Technology

Directory of Open Access Journals (Sweden)

Olga Mironova

2017-11-01

Full Text Available The present paper demonstrates the teaching approach in programming basics course for novices: schoolchildren of different ages and schoolteachers. This programming course was developed at the Institute of Informatics at Tallinn University of Technology in Tallinn, Estonia and it based on many years experience in teaching programming for non-IT first year students. The main aim of the chosen teaching approach in the course is to raise the motivation and keep the learners’ interest in programming field on the high level. The idea of developed teaching technique is the implementation of the visual programming before a serious textual coding. Furthermore, authors suggest readers some ways and methods to overcome learners’ difficulties in the first stage in a textual coding.

Püha Siimeoni ja Naisprohvet Hanna kiriku restaureerimine : Ahtri 5, Tallinn = Restoration of the Church of Righteous Symeon and Prophetess Ann : Ahtri 5, Tallinn / Epp Lankots

Index Scriptorium Estoniae

Lankots, Epp, 1976-

2005-01-01

18. sajandil ehitatud, 2001. a. Eesti Apostlik-Õigeusu Kirikule tagastatud kirikuhoone restaureerimine. Ees on interjööride konserveerimistööd. Uuringud: Juhan Kilumets, Eva Mölder. Arhitektuurne projekt: Tõnu Parmakson, Ilmar Kannelmäe. Konstruktiivne projekt: Aleksander Danil. Teostus: J. Kilumets (Rändmeister), T. Parmakson (Frantsiskus), E. Mölder (Vana Tallinn). Ill.: 3 värv. välis- ja 3 sisevaadet

A Distributed Python HPC Framework: ODIN, PyTrilinos, & Seamless

Energy Technology Data Exchange (ETDEWEB)

Grant, Robert [Enthought, Inc., Austin, TX (United States)

2015-11-23

Under this grant, three significant software packages were developed or improved, all with the goal of improving the ease-of-use of HPC libraries. The first component is a Python package, named DistArray (originally named Odin), that provides a high-level interface to distributed array computing. This interface is based on the popular and widely used NumPy package and is integrated with the IPython project for enhanced interactive parallel distributed computing. The second Python package is the Distributed Array Protocol (DAP) that enables separate distributed array libraries to share arrays efficiently without copying or sending messages. If a distributed array library supports the DAP, it is then automatically able to communicate with any other library that also supports the protocol. This protocol allows DistArray to communicate with the Trilinos library via PyTrilinos, which was also enhanced during this project. A third package, PyTrilinos, was extended to support distributed structured arrays (in addition to the unstructured arrays of its original design), allow more flexible distributed arrays (i.e., the restriction to double precision data was lifted), and implement the DAP. DAP support includes both exporting the protocol so that external packages can use distributed Trilinos data structures, and importing the protocol so that PyTrilinos can work with distributed data from external packages.

Tallinn Fashion Week täidab nädala kodumaise moega / Karilin Engelbrecht

Index Scriptorium Estoniae

Engelbrecht, Karilin

2009-01-01

Tallinn Fashion Week'i üritustest. Ülevaade eesti moekunstnike loomingu esitlustest. Näitus "Uus Eesti moejoonistus" Arhitektuuri- ja Disainigaleriis. Anu Hindi moefotonäitus "Aeg maha 3" Iida galeriis. Raamatu "Eesti moepiibel 2010" esitlus Rotermanni kvartali kohvikus Platz. Oksana Tanditi ja Filippo Caroti moefotonäitus "Butterflies" Tallinna botaanikaaias

BL-2a and BL-4a: certified uranium reference ores

International Nuclear Information System (INIS)

Steger, H.F.; Bowman, W.S.; Zechanowitsch, G.; Sutarno, R.

1982-05-01

Samples of two uranium ores BL-2a and BL-4a from Beaverlodge, Saskatchewan, were prepared as compositional reference materials to replace the similar certified ores, BL-2 and BL-4, of which the stock had been exhausted. Each ore was ground to minus 74 μm, blended in one lot and bottled in 200-g units. The homogeneity of the ores with respect to uranium was confirmed by both a neutron activation and a fluorimetric analytical procedure performed by two commercial laboratories. The recommended value for uranium is based on the results of one determination on each of 25 bottles by the volumetric-umpire method performed at CANMET. A statistical analysis of the data gave a recommended value for uranium of 0.426% for BL-2a and 0.1248% for BL-4a

Bob Scott: Tallinn 2011 saab oma preemiaraha kätte / Bob Scott ; intervjueerinud Teele Tammeorg

Index Scriptorium Estoniae

Scott, Bob

2010-01-01

Euroopa kultuuripealinnade hindamiskomisjoni esimees räägib oma kohtumisest Tallinna linnapea Edgar Savisaare ja kultuuriministri Laine Jänesega ning sellest, et Tallinnal ja Eestil tuleb lisatoetuse saamiseks saata Euroopa Komisjonile vaid kiri, milles nad kinnitavad, et kultuuripealinna programmi jaoks on raha olemas

B-L mediated SUSY breaking with radiative B-L symmetry breaking

International Nuclear Information System (INIS)

Kikuchi, Tatsuru; Kubo, Takayuki

2008-01-01

We explore a mechanism of radiative B-L symmetry breaking in analogous to the radiative electroweak symmetry breaking. The breaking scale of B-L symmetry is related to the neutrino masses through the see-saw mechanism. Once we incorporate the U(1) B-L gauge symmetry in SUSY models, the U(1) B-L gaugino, Z-tilde B-L appears, and it can mediate the SUSY breaking (Z-prime mediated SUSY breaking) at around the scale of 10 6 GeV. Then we find a links between the neutrino mass (more precisly the see-saw or B-L scale of order 10 6 GeV) and the Z-prime mediated SUSY breaking scale. It is also very interesting that the gluino at the weak scale becomes relatively light, and almost compressed mass spectra for the gaugino sector can be realized in this scenario, which is very interesting in scope of the LHC.

"Tallinn Treff" - maailma lavade uus põlvkond Tallinnas / Meelis Pai, Vahur Keller, Reeda Toots ; intervjueerinud Margot Visnap

Index Scriptorium Estoniae

Pai, Meelis, 1968-

2009-01-01

30. maist 6. juunini toimuvast rahvusvahelisest nukuteatrifestivalist "Tallinn Treff" ning selle alafestivalist "Noor vaim" annavad ülevaate festivali peakorraldaja Meelis Pai, kusntiline juht Vahut Keller ja "Noor vaimu" juht Reeda Toots

Characteristics of cardiovascular deaths in forensic medical cases in Budapest, Vilnius and Tallinn.

Science.gov (United States)

Törő, Klara; Väli, Marika; Lepik, Delia; Tuusov, Jana; Dunay, György; Marcsa, Boglarka; Pauliukevicius, Alvydas; Raudys, Romas; Caplinskiene, Marija

2013-11-01

Evaluation of the pathomorphological characteristics of cases involving natural and sudden cardiovascular death is essential for the determination of the cause of death. The main purpose of this study is to investigate sudden unexpected cardiovascular death and to study how different geographical climatic influences may affect cardiac mortality in three capitals: Budapest, Vilnius and Tallinn. There were 8482 (5753 male, 2729 female) cardiovascular deaths between 2005 and 2009. The highest rate was observed in the age group between 71 and 80 years (35.17%) and 51-60 years (24.45%). The highest number of cardiovascular deaths occur in January (805/9.49%) and December (770/9.07%). Seasonal distribution was observed, with winter prevalence in Tallinn (279/3.20%) and spring prevalence in Vilnius (760/8.90%). Though in Vilnius and Budapest a great number of deaths occurred in winter and spring, any correlation with other factors (e.g. age, gender, BAC) was not statistically significant. Based on our results we can conclude that environmental-geographical parameters may affect natural cardiovascular death. Examination of pathological patterns and predisposing environmental parameters may help to improve prevention strategies. Copyright © 2013. Published by Elsevier Ltd.

Uudised : Preemia "edition 49" noodigraafikale. Noor muusik ئ Tallinn 2000. Bergenisse sõidab Bezrodnaja / Hugo Alter

Index Scriptorium Estoniae

Alter, Hugo-Eduard, 1929-2003

2000-01-01

Kirjastuse "Edition 49" noodigraafikaga teos võitis muusikakirjastuspreemia "Frankfurt 2000". 6.-9. juunini toimub rahvusvaheline konkurss "Noor muusik ئ Tallinn 2000", millest võtavad osa kuni 13 aastased muusikud 11-st riigist. "Klassika-Eurovisiooni" Eesti võistluse finaali võitis A.-L. Bezrodnaja, kes esindab Eestit võistluse Euroopa finaalis juunis Bergenis

[Heinz von zur Mühlen. Paul Johansen und die Sogenannten Undeutschen in Reval/Tallinn] / Paul Kaegbein

Index Scriptorium Estoniae

Kaegbein, Paul

2008-01-01

Arvustus: Heinz von zur Mühlen. Paul Johansen und die Sogenannten Undeutschen in Reval/Tallinn. - Nordosteuropa als Geschichtsregion. Helsinki : Aue-Stiftung :; Lübeck : Schmidt-Römhild, 2006. lk. 103-111. Paul Johanseni lähim töökaaslane kirjeldab teose "Deutsch und Undeutsch im mittelalterlichen und frühneuzeitlichen Reval" valmimist

Properties of BL Lac objects

International Nuclear Information System (INIS)

Wolfe, A.M.; Pittsburgh, University, Pittsburgh, Pa.)

1980-01-01

The properties of BL Lacertae objects are examined in light of their recently realized similarities to quasars and associations with galactic radiation. The criteria typically used to define BL Lac objects are analyzed, with attention given to radio spectra, optical continual, radio and optical variability, optical polarization and emission lines, and evidence that BL Lac objects and optically violent variables represent the most compact and strongly variable sources among the general class of quasars is discussed. Connections between BL Lac objects and the galaxies in which they have been observed to be embedded are discussed and it is pointed out that no low-luminosity quasars have been found to be associated with first-ranked giant ellipticals. Future observations which may clarify the properties and relationships of BL Lac objects are indicated

BL Lacertae objects

International Nuclear Information System (INIS)

Miller, J.S.

1978-01-01

An overview is given of the principal characteristics and problems associated with the prototype BL Lacertae. The most important characteristics of this group and its relevance, the consideration of a few particular objects in moderate detail, the relation between these objects QSOs, and normal galaxies, and finally the possible physical nature of BL Lac objects and the important questions they raise are treated. 15 references

Stable Water Isotopologues in the Stratosphere Retrieved from Odin/SMR Measurements

Directory of Open Access Journals (Sweden)

Tongmei Wang

2018-01-01

Full Text Available Stable Water Isotopologues (SWIs are important diagnostic tracers for understanding processes in the atmosphere and the global hydrological cycle. Using eight years (2002–2009 of retrievals from Odin/SMR (Sub-Millimetre Radiometer, the global climatological features of three SWIs, H216O, HDO and H218O, the isotopic composition δD and δ18O in the stratosphere are analysed for the first time. Spatially, SWIs are found to increase with altitude due to stratospheric methane oxidation. In the tropics, highly depleted SWIs in the lower stratosphere indicate the effect of dehydration when the air comes through the cold tropopause, while, at higher latitudes, more enriched SWIs in the upper stratosphere during summer are produced and transported to the other hemisphere via the Brewer–Dobson circulation. Furthermore, we found that more H216O is produced over summer Northern Hemisphere and more HDO is produced over summer Southern Hemisphere. Temporally, a tape recorder in H216O is observed in the lower tropical stratosphere, in addition to a pronounced downward propagating seasonal signal in SWIs from the upper to the lower stratosphere over the polar regions. These observed features in SWIs are further compared to SWI-enabled model outputs. This helped to identify possible causes of model deficiencies in reproducing main stratospheric features. For instance, choosing a better advection scheme and including methane oxidation process in a specific model immediately capture the main features of stratospheric water vapor. The representation of other features, such as the observed inter-hemispheric difference of isotopic component, is also discussed.

A Search for Low-Luminosity BL Lacertae Objects

Science.gov (United States)

Rector, Travis A.; Stocke, John T.; Perlman, Eric S.

1999-05-01

Many properties of BL Lacs have become explicable in terms of the ``relativistic beaming'' hypothesis, whereby BL Lacs are FR 1 radio galaxies viewed nearly along the jet axis. However, a possible problem with this model is that a transition population between beamed BL Lacs and unbeamed FR 1 galaxies has not been detected. A transition population of ``low-luminosity BL Lacs'' was predicted to exist in abundance in X-ray-selected samples such as the Einstein Extended Medium Sensitivity Survey (EMSS) by Browne & Marcha. However, these BL Lacs may have been misidentified as clusters of galaxies. We have conducted a search for such objects in the EMSS with the ROSAT High-Resolution Imager (HRI) here we present ROSAT HRI images, optical spectra, and VLA radio maps for a small number of BL Lacs that were previously misidentified in the EMSS catalog as clusters of galaxies. While these objects are slightly lower in luminosity than other EMSS BL Lacs, their properties are too similar to the other BL Lacs in the EMSS sample to ``bridge the gap'' between BL Lacs and FR 1 radio galaxies. Also, the number of new BL Lacs found is too low to alter significantly the X-ray luminosity function or value for the X-ray-selected EMSS BL Lac sample. Thus, these observations do not explain fully the discrepancy between the X-ray- and radio-selected BL Lac samples.

The Discovery of Low-Luminosity BL Lacs

Science.gov (United States)

Rector, Travis A.; Stocke, John T.

1995-12-01

Many of the properties of BL Lacs have become explicable in terms of the ``relativistic beaming'' hypothesis whereby BL Lacs are ``highly beamed'' FR-I radio galaxies (i.e. our line of sight to these objects is nearly along the jet axis). Further, radio-selected BL Lacs (RBLs) are believed to be seen nearly ``on-axis'' (the line-of-sight angle theta ~ 8deg ) while X-ray selected BL Lacs (XBLs) are seen at larger angles (theta ~ 30deg ; the X-ray emitting jet is believed to be less collimated). However, a major problem with this model was that a transition population between beamed BL Lacs and unbeamed FR-Is had not been detected. Low-luminosity BL Lacs may be such a transition population, and were predicted to exist by Browne and Marcha (1993). We present ROSAT HRI images, VLA radio maps and optical spectra which confirm the existence of low-luminosity BL Lacs, objects which were previously mis-identified in the EMSS catalog as clusters of galaxies. Thus our results strengthen the relativistic beaming hypothesis.

Russification of non-Estonian pupils in Tallinn

Directory of Open Access Journals (Sweden)

Ülle Rannut

2010-05-01

Full Text Available In the article home languages, their qualities and use by pupils in grades 2 to 5 in Tallinn are analyzed. Two larger and more characteristic groups (Ukrainians and Belarusians and two groups with Islamic backgrounds (Azerbaijanis and Tatars were compared with the aim of analysing different language loss and preservation factors. Although Ukrainians and Belarusians form much larger ethnic groups within Estonia, they have not managed to preserve their language anywhere near as successfully as the Azerbaijanis and Tatars. Comparison of the data suggests that language preservation in Estonia and the ability to withstand Russification are most influenced by the degree of difference of the language from Russian and the religious difference from the Russian Orthodox faith (and Soviet era atheism. Home languages are characterised by their use mainly in the verbal form, with skills in the literary language generally low or even non-existent. Languages are for the most part learned informally, primarily through communication with parents and/or grandparents. The result is a supersaturated vernacular with a large degree of variation and loans from superstratum languages which falls far from the standard of the language in question.DOI: http://dx.doi.org/10.5128/ERYa6.15

Cloning, expression, purification, crystallization and preliminary X-ray analysis of the human RuvBL1–RuvBL2 complex

International Nuclear Information System (INIS)

Gorynia, Sabine; Matias, Pedro M.; Bandeiras, Tiago M.; Donner, Peter; Carrondo, Maria Arménia

2008-01-01

A truncated variant of the human RuvBL1–RuvBL2 complex was cloned, expressed, purified and crystallised. Synchrotron diffraction data to 4 Å resolution were used to carry out a preliminary crystallographic analysis of the complex. The complex of RuvBL1 and its homologue RuvBL2, two evolutionarily highly conserved eukaryotic proteins belonging to the AAA + (ATPase associated with diverse cellular activities) family of ATPases, was co-expressed in Escherichia coli. For crystallization purposes, the flexible domains II of RuvBL1 and RuvBL2 were truncated. The truncated RuvBL1–RuvBL2 complex was crystallized using the hanging-drop vapour-diffusion method at 293 K. The crystals were hexagonal-shaped plates and belonged to either the orthorhombic space group C222 1 , with unit-cell parameters a = 111.4, b = 188.0, c = 243.4 Å and six monomers in the asymmetric unit, or the monoclinic space group P2 1 , with unit-cell parameters a = 109.2, b = 243.4, c = 109.3 Å, β = 118.7° and 12 monomers in the asymmetric unit. The crystal structure could be solved by molecular replacement in both possible space groups and the solutions obtained showed that the complex forms a dodecamer

Retsensioon : Riigikogu VII, VIII ja IX koosseis. Statistikat ja kommentaare. Peatoimetaja Aaro Mõttus. Tallinn : Riigikogu Kantselei, Eesti Rahvusraamatukogu, 2004. 326 lk. / Mart Nutt

Index Scriptorium Estoniae

Nutt, Mart, 1962-

2004-01-01

Arvustus: Riigikogu VII, VIII ja IX koosseis. Statistikat ja kommentaare / peatoim. Aaro Mõttus. Tallinn : Riigikogu Kantselei, Eesti Rahvusraamatukogu, 2004. - Lisatud: Ott Heinapuu tutvustav sõnum retsenseeritud väljaande kohta lk. 193. - Vt. ka: http://www.riigikogu.ee/rito/index.php?id=11357

On the close environment of BL Lacertae objects

Energy Technology Data Exchange (ETDEWEB)

Falomo, R. (Osservatorio Astronomico di Padova (Italy)); Melnick, J. (European Southern Observatory, Santiago (Chile)); Tanzi, E.G. (Consiglio Nazionale delle Ricerche, Milan (Italy))

1990-06-21

The local environment of BL Lacertae objects, which resemble quasars but lack emission lines, is poorly understood. In the few cases where the surrounding nebulosity has been studied in detail, it is consistent with the presence of a giant elliptical galaxy, but the evidence that the BL Lac and the putative galaxy are physically associated rests solely on their positional coincidence. An alternative hypothesis, that BL Lacs are gravitationally lensed and that the surrounding emission is from the foreground lensing object, gains some support from a number of observations which reveal less than perfect alignment between BL Lacs and surrounding emission. We have begun a systematic programme of high-resolution imaging aimed at understanding in a general way the local environment of BL Lacs. Here we describe a first series of images, which show the presence of emission features around most of the BL Lacs observed. Typically, this emission is close (<5 arcsec) to the BL Lac, and faint (m{sub R} = 21). We discuss the interpretation of these companions in terms of both interacting objects and gravitational lenses. (author).

Clustering environments of BL Lac objects

Science.gov (United States)

Wurtz, Ronald; Ellingson, Erica; Stocke, John T.; Yee, H. K. C.

1993-01-01

We report measurements of the amplitude of the BL Lac galaxy spatial covariance function, B(gb), for the fields of five BL Lacertae objects. We present evidence for rich clusters around MS 1207+39 and MS 1407+59, and confirm high richness for the cluster containing H0414+009. We discuss the ease of 3C 66 A and find evidence for a poor cluster based on an uncertain redshift of z = 0.444. These data suggest that at least some BL Lac objects are consistent with being FR 1 radio galaxies in rich clusters.

The cosmic evolution of Fermi BL Lacertae objects

International Nuclear Information System (INIS)

Ajello, M.; Romani, R. W.; Shaw, M. S.; Healey, S. E.; Michelson, P. F.; Gasparrini, D.; Bolmer, J.; Cotter, G.; Potter, W. J.; Finke, J.; Greiner, J.; Rau, A.; Schady, P.; King, O.; Max-Moerbeck, W.; Readhead, A. C. S.; Richards, J. L.

2014-01-01

Fermi has provided the largest sample of γ-ray-selected blazars to date. In this work we use a uniformly selected set of 211 BL Lacertae (BL Lac) objects detected by Fermi during its first year of operation. We obtained redshift constraints for 206 out of the 211 BL Lac objects in our sample, making it the largest and most complete sample of BL Lac objects available in the literature. We use this sample to determine the luminosity function of BL Lac objects and its evolution with cosmic time. We find that for most BL Lac classes the evolution is positive, with a space density peaking at modest redshift (z ≈ 1.2). Low-luminosity, high-synchrotron-peaked (HSP) BL Lac objects are an exception, showing strong negative evolution, with number density increasing for z ≲ 0.5. Since this rise corresponds to a drop-off in the density of flat-spectrum radio quasars (FSRQs), a possible interpretation is that these HSPs represent an accretion-starved end state of an earlier merger-driven gas-rich phase. We additionally find that the known BL Lac correlation between luminosity and photon spectral index persists after correction for the substantial observational selection effects with implications for the so-called 'blazar sequence'. Finally, by estimating the beaming corrections to the luminosity function, we find that BL Lac objects have an average Lorentz factor of γ=6.1 −0.8 +1.1 , and that most are seen within 10° of the jet axis.

Data Envelopment Analysis of Helsinki-Tallinn Transportation Chains

Directory of Open Access Journals (Sweden)

Olli-Pekka Hilmola

2013-12-01

Full Text Available The Baltic Sea shipping is at a crossroads as sulphur regulation will lead to excessive cost increases from the year 2015 onwards and CO2 emission trading is planned to be implemented for the entire shipping sector within the EU area. Therefore, shipping is going to be minimized and hinterland transportation (road and rail will act as substitute. This research analyzes the situation on one of the highest volume general cargo transportation routes of Finland (operating between Helsinki, Finland and Tallinn, Estonia, including loading and unloading at seaports and short sea shipping activity in between. Based on the efficiency evaluation results, it seems that containers should be favoured over semi-trailers – containers could be carried efficiently either in container ships or even at currently favoured RoRo or RoPax ships. Our research illustrates that pure container shipping with larger container ships within the analyzed route is not entirely out of question, but lead time and hinterland operations should receive more attention. Alternatively, RoRo and RoPax ships can also do something to increase their competitiveness in environmental harm caused and diesel consumption – higher cargo loads and utilization levels are short-term key for continued dominance.

Radium-226 in certified uranium reference ores DL-1a, BL-4a, DH-1a and BL-5

International Nuclear Information System (INIS)

Smith, C.W.; Steger, H.F.

1983-05-01

Radium-226 radioactivity in uranium reference ores BL-4a and BL-5 and uranium-thorium reference ores DL-1a and DH-1a was determined in an interlaboratory program. Twelve of thirteen participants used certified radium solutions from the United States National Bureau of Standards (NBS) for calibration purposes. Recommended values of sup(226)Ra activity and associated parameters were calculated by statistical treatment of the results. In all cases, the recommended values are within 2 percent of activities predicted assuming secular equilibrium in the sup(238)U decay series. The recommended values for radium activity are 1.40, 15.5, 31.5 and 857 Bq/ for DL-1a, BL-4a, DH-1a and BL-5, respectively

The near-infrared continua of BL Lacertae objects

International Nuclear Information System (INIS)

Allen, D.A.; Ward, M.J.; Hyland, A.R.

1982-01-01

Accurate photometry at J, H and K (1.2 to 2.2 μm) has been secured of 53 BL Lac objects. A power-law continuum is an exceptionally good fit to the data, and the colours are distinct from those of quasars. There is no indication of the additional infrared continuum seen in quasars and which is believed to arise in circumnuclear dust. We argue that dust is very scarce in the nuclei of BL Lac objects, and thus we expect gas to be equally scarce. Hence we attribute the lack of optical emission lines to an absence of ionized nuclear gas. We further argue that BL Lac objects could underlie quasars, the latter exhibiting line and thermal continuum emission at ultraviolet, optical and near-infrared wavelengths due to the presence of circumnuclear gas and dust. The strong-lined optically violent variable quasars have colours typical of BL Lac objects rather than quasars, and may represent intermediate cases. The JHK colours of the BL Lac objects overlap with those of the empty-radio-field infrared sources. Such objects probably represent the redder extreme of a range of spectral indices in BL Lac objects. (author)

No evidence for radio-quiet BL Lacertae objects

International Nuclear Information System (INIS)

Stocke, J.T.; Morris, S.L.; Gioia, I.; Maccacaro, T.; Schild, R.E.

1990-01-01

Using a large, flux-limited sample of faint X-ray sources, a search has been conducted for radio-quiet BL Lacertae objects. None has been found. Thirty-two X-ray-selected BL Lac objects and BL Lac candidates have been found within the sources of the Einstein Medium Sensitivity Survey (EMSS). Thirty-one of these have been observed with the VLA and all have been detected at 5 GHz. While the optical magnitudes of the EMSS BL Lac objects range from 17 to 20.8, their radio-to-optical spectral indices occupy a very small range. The very bright X-ray-selected BL Lac objects like PKS 2155-304 and Markarian 501 have similar range values. Therefore, unlike the clear dichotomy between radio-loud quasars and radio-quiet QSOs, there is no evidence for two populations of Lacertids distinguished by radio loudness. 43 refs

76 FR 21946 - Proposed Collection; Comment Request for Form 990-BL; Schedule A (Form 990-BL), Form 6069

Science.gov (United States)

2011-04-19

... Initial Excise Tax Return for Black Lung Benefit Trusts and Certain Related Persons, and Form 6069, Return of Excise Tax on Excess Contributions to Black Lung Benefit Trust Under Section 4953 and Computation...: Form 990-BL, Schedule A (Form 990-BL), Information and Initial Excise Tax Return for Black Lung Benefit...

ALARM, a life saving training program for inpatient mental health care staff. Tallinn, Estland (27-30 augustus 2014) : Oral presentation European Symposium on Suicide and Suicidal Behaviour

NARCIS (Netherlands)

Nienke Kool

2014-01-01

Oral presentation European Symposium on Suicide and Suicidal Behaviour. Titel: ALARM, a life saving training program for inpatient mental health care staff. Tallinn, Estland (27-30 augustus 2014) Introduction Despite precautions, suicide does happen. Sometimes patients are found while attempting

Kohtumispaigad: Tallinna kohvikute interjööre = Meeting Places : Interiors of Tallinn Cafes / Kai Lobjakas ; tõlk. Laila Põdra

Index Scriptorium Estoniae

Lobjakas, Kai, 1975-

2003-01-01

Tallinna kohvikutest aastail 1930-2003. Vaadeldakse kohvikuid Corso/Harju, Feischner/Tallinn, Palace, Kultas/Moskva, Energia, Narva, Pärl, Pegasus, Tuluke, Szolnok, Tuljak, Vigri, Toome, Corrida, Võitlev Sõna, Robert's Coffee, Rossini, Popular. Sisekujundajad: R. Natus, V. Tomassov, K. Herman, B. Linde, J. Siirak, V. Asi, V. Tamm, L. Pärtelpoeg, N. Kultas, P. Aren, H. Karro, G. Nahkur, L. Tarvas, M. Grünberg, A. Murdmaa, M. Tammik, G. Sarv, A. Maasik, A. Nurk, R. Treu, M. Sulengo, R. Tiitus. 22 vaadet, kaart

Revised Correlation between Odin/OSIRIS PMC Properties and Coincident TIMED/SABER Mesospheric Temperatures

Science.gov (United States)

Feofilov, A. G.; Petelina, S. V.; Kutepov, A. A.; Pesnell, W. D.; Goldberg, R. A.; Llewellyn, E. J.; Russell, J. M.

2006-01-01

The Optical Spectrograph and Infrared Imaging System (OSIRIS) instrument on board the Odin satellite detects Polar Mesospheric Clouds (PMCs) through the enhancement in the limb-scattered solar radiance. The Sounding of the Atmosphere using the Broadband Emission Radiometry (SABER) instrument on board the TIMED satellite is a limb scanning infrared radiometer that measures temperature and vertical profiles and energetic parameters for minor constituents in the mesosphere and lower thermosphere. The combination of OSIRIS and SABER data has been previously used to statistically derive thermal conditions for PMC existence [Petelina et al., 2005]. a, A.A. Kutepov, W.D. Pesnell, In this work, we employ the simultaneous common volume measurements of PMCs by OSIRIS and temperature profiles measured by SABER for the Northern Hemisphere summers of 2002-2005 and corrected in the polar region by accounting for the vibrational-vibrational energy exchange among the CO2 isotopes [Kutepov et al., 2006]. For each of 20 coincidences identified within plus or minus 1 degree latitude, plus or minus 2 degrees longitude and less than 1 hour time the frost point temperatures were calculated using the corresponding SABER temperature profile and water vapor densities of 1,3, and 10 ppmv. We found that the PMC presence and brightness correlated only with the temperature threshold that corresponds to the frost point. The absolute value of the temperature below the frost point, however, didn't play a significant role in the intensity of PMC signal for the majority of selected coincidences. The presence of several bright clouds at temperatures above the frost point is obviously related to the limitation of the limb geometry when some near- or far-field PMCs located at higher (and warmer) altitudes appear to be at lower altitudes.

[Nordosteuropa als Geschichtsregion. Beiträge des III. Internationalen Symposiums zur deutschen Kultur und Geschichte im europäischen Nordosten vom 20.-22. September 2001 in Tallinn

Index Scriptorium Estoniae

Lawaty, Andreas

2011-01-01

Arvustus : Nordosteuropa als Geschichtsregion. Beiträge des III. Internationalen Symposiums zur deutschen Kultur und Geschichte im europäischen Nordosten vom 20.-22. September 2001 in Tallinn. Lübeck : Verlag Schmidt-Römhild 2006. (Veröffentlihungen der Aue-Stiftung. 17)

Eesti Gaas. Inspection of Kohtal-Jaerve - Tallinn pipeline. Final report

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-11-01

The project `Inspection of Pipelines in Estonia` was funded by Danish government and was carried out in collaboration between DONG, Balslev and FORCE. By agreement between Eesti Gaas and DONG, the pipeline system between Kohtla-Jaerve and Tallinn was selected for inspection. This pipeline system has a total length of 176.9 km. The objective of the project has been, based on detailed inspection of relative short lengths of pipe, to determine the integrity of the pipeline and to give advice concerning the continued use as a high pressure transmission pipeline. The objectives have been met as set out by the project Proposal with the investigation and this report as follows: Based on a document review together with the measurements and observations in the field and in the laboratory, the condition of approximately 5 km of the pipeline has been evaluated; Recommendations are given in this report with the aim of extending the life of the pipeline. A further objective has been to provide know-how transfer in order to permit Eesti Gaas to run similar inspections on other parts of their transmission system. (EG)

Behavioral profiles of three C57BL/6 substrains

Directory of Open Access Journals (Sweden)

Naoki Matsuo

2010-06-01

Full Text Available C57BL/6 inbred strains of mice are widely used in knockout and transgenic research. To evaluate the loss-of-function and gain-of-function effects of the gene of interest, animal behaviors are often examined. However, an issue of C57BL/6 substrains that is not always appreciated is that behaviors are known to be strongly influenced by genetic background. To investigate the behavioral characteristics of C57BL/6 substrains, we subjected C57BL/6J, C57BL/6N, and C57BL/6C mice to a behavior test battery. We performed both a regular-scale analysis, in which experimental conditions were tightly-controlled, and meta-analysis from large number of behavioral data that we have collected so far through the comprehensive behavioral test battery applied to 700-2,200 mice in total. Significant differences among the substrains were found in the results of various behavioral tests, including the open field, rotarod, elevated plus maze, prepulse inhibition, Porsolt forced swim, and spatial working memory version of the 8-arm radial maze. Our results show a divergence of behavioral performance in C57BL/6 substrains, which suggest that small genetic differences may have a great influence on behavioral phenotypes. Thus, the genetic background of different substrains should be carefully chosen, equated, and considered in the interpretation of mutant behavioral phenotypes.

BL Lacertae objects

International Nuclear Information System (INIS)

Disney, M.J.; Veron, P.

1977-01-01

The properties of BL Lacertae objects are discussed including their spectra, variability, and brightness. The historical development of observation, and the conclusion that these objects are possibly quasar-related objects rather than variable stars as originally supposed are treated. The possible mechanisms for the unusual luminosity of these objects are considered

Health impact assessment of particulate pollution in Tallinn using fine spatial resolution and modeling techniques

Directory of Open Access Journals (Sweden)

Kimmel Veljo

2009-03-01

Full Text Available Abstract Background Health impact assessments (HIA use information on exposure, baseline mortality/morbidity and exposure-response functions from epidemiological studies in order to quantify the health impacts of existing situations and/or alternative scenarios. The aim of this study was to improve HIA methods for air pollution studies in situations where exposures can be estimated using GIS with high spatial resolution and dispersion modeling approaches. Methods Tallinn was divided into 84 sections according to neighborhoods, with a total population of approx. 390 000 persons. Actual baseline rates for total mortality and hospitalization with cardiovascular and respiratory diagnosis were identified. The exposure to fine particles (PM2.5 from local emissions was defined as the modeled annual levels. The model validation and morbidity assessment were based on 2006 PM10 or PM2.5 levels at 3 monitoring stations. The exposure-response coefficients used were for total mortality 6.2% (95% CI 1.6–11% per 10 μg/m3 increase of annual mean PM2.5 concentration and for the assessment of respiratory and cardiovascular hospitalizations 1.14% (95% CI 0.62–1.67% and 0.73% (95% CI 0.47–0.93% per 10 μg/m3 increase of PM10. The direct costs related to morbidity were calculated according to hospital treatment expenses in 2005 and the cost of premature deaths using the concept of Value of Life Year (VOLY. Results The annual population-weighted-modeled exposure to locally emitted PM2.5 in Tallinn was 11.6 μg/m3. Our analysis showed that it corresponds to 296 (95% CI 76528 premature deaths resulting in 3859 (95% CI 10236636 Years of Life Lost (YLL per year. The average decrease in life-expectancy at birth per resident of Tallinn was estimated to be 0.64 (95% CI 0.17–1.10 years. While in the polluted city centre this may reach 1.17 years, in the least polluted neighborhoods it remains between 0.1 and 0.3 years. When dividing the YLL by the number of

[Kreem, Juhan. Sketches of a Clerk. Pen-and-ink Drawings in the Margins of the Medieval Accoung Books of Reval (Tallinn)] / Anu Mänd

Index Scriptorium Estoniae

Mänd, Anu, 1968-

2008-01-01

Arvustus: Kreem, Juhan. Sketches of a Clerk. Pen-and-ink Drawings in the Margins of the Medieval Accoung Books of Reval (Tallinn). (Krems, 2006). Juhan Kreemi raamat käsitleb Tallinna rae keskaegsetes arveraamatutes leiduvaid sulejoonistusi. Autor on välja selgitanud nende, esmapilgul juhuslikena näivate joonistuste otstarbe ning püüdnud nende kaudu avada tolleaegsete linnaametnike mõttemalle

[Nordosteuropa als Geschichtsregion : Beiträge des III. Internationalen Symposiums zur Deutschen Kultur und Geschichte im Europäischen Nordosten vom 20. - 22. September 2001 in Tallinn (Estland)] / Janet Laidla

Index Scriptorium Estoniae

Laidla, Janet, 1982-

2008-01-01

Arvustus: Nordosteuropa als Geschichtsregion : Beiträge des III. Internationalen Symposiums zur Deutschen Kultur und Geschichte im Europäischen Nordosten vom 20. - 22. September 2001 in Tallinn (Estland). (Helsinki : Aue-Stiftung ; Lübeck : Scmidt-Römhild, 2006)

HYDROGEOLOGIC CHARACTERIZATION OF THE U-3bl COLLAPSE ZONE

International Nuclear Information System (INIS)

Bechtel Nevada and National Security Technologies, LLC

2006-01-01

The U-3bl collapse crater was formed by an underground nuclear test in August 1962. This crater and the adjoining U-3ax crater were subsequently developed and used as a bulk low-level radioactive waste disposal cell (U-3ax/bl), which is part of the Area 3 Radioactive Waste Management Site at the Nevada Test Site (NTS). Various investigations have been conducted to assess the hydrogeologic characteristics and properties in the vicinity of the U-3ax/bl waste disposal cell. This report presents data from one of these investigations, conducted in 1996. Also included in this report is a review of pertinent nuclear testing records, which shows that the testing operations and hydrogeologic setting of the U-3ax/bl site were typical for the period and location of testing

Broad band energy distribution of UV-bright BL Lac objects

International Nuclear Information System (INIS)

Maraschi, L.; Tanzi, E.G.; Treves, A.

1984-01-01

IUE satellite data in the 1200-2000 and 1900-3200 A intervals of BL Lac objects are analyzed in terms of two discernible groups. A total of 25 BL Lac objects were observed, with differences between groups displayed in terms of the power slope of the energy of the UV emissions, i.e., slopes of 1 and 2. Comparisons of the spectra with those of quasars showed that quasars have a small spectral index in the 1000-6000 A band and no correlation exists between the spectral index and UV flux of the BL Lac objects. The comparisons underscore the lack of a thermal component for BL Lac objects. Steep spectral components in both BL Lac objects and highly polarized quasars emissions could both be due to synchrotron emission. Compton scattering of relativistic electrons off synchrotron photons could produce the X ray emissions. 44 references

Broad band energy distribution of UV-bright BL Lac objects

Energy Technology Data Exchange (ETDEWEB)

Maraschi, L.; Tanzi, E.G.; Treves, A.

1984-01-01

IUE satellite data in the 1200-2000 and 1900-3200 A intervals of BL Lac objects are analyzed in terms of two discernible groups. A total of 25 BL Lac objects were observed, with differences between groups displayed in terms of the power slope of the energy of the UV emissions, i.e., slopes of 1 and 2. Comparisons of the spectra with those of quasars showed that quasars have a small spectral index in the 1000-6000 A band and no correlation exists between the spectral index and UV flux of the BL Lac objects. The comparisons underscore the lack of a thermal component for BL Lac objects. Steep spectral components in both BL Lac objects and highly polarized quasars emissions could both be due to synchrotron emission. Compton scattering of relativistic electrons off synchrotron photons could produce the X ray emissions. 44 references.

Infrared polarimetry and photometry of BL Lac objects. 3

Energy Technology Data Exchange (ETDEWEB)

Holmes, P A; Brand, P W.J.L. [Edinburgh Univ. (UK). Dept. of Astronomy; Impey, C D [Hawaii Univ., Honolulu (USA). Inst. for Astronomy; Williams, P M [UKIRT, Hilo, HI (USA)

1984-10-15

The data presented here is part of a continuing monitoring programme of BL lac objects with J, H and K photometry and polarimetry. A total of 30 BL Lac objects have now been observed photometrically. Infrared polarimetry has also been obtained for 24 of these objects. The sample is sufficiently large to examine statistically, and several important correlations have emerged. Internight variations and wavelength dependence of polarization indicate that BL Lac objects, as a class, may be understood in terms of a relatively simple two-component model.

Studies on a transplantable C57BL/6 mouse lymphoma

International Nuclear Information System (INIS)

Kendall, C.E.

1977-01-01

A C57BL/6 mouse lymphoma was demonstrated to be of T cell origin by treating the lymphoma cells with anti-Thy 1.2 antisera in a complement-dependent cytotoxicity test. The lymphoma's growth pattern was described using flow microfluorometric determinations and spleen weight progression. C-type particles were identified in electron micrographs of the lymphoma. C57BL/6 mice were immunized against the lymphoma by injecting x-ray inactivated lymphoma cells into the mice. Protection of immunized mice against live lymphoma cells demonstrated tumor antigens on the lymphoma cells. The success of immunization was found to depend on: route of injection, antigen dosage, state of the antigen, number of injections and the vaccination-challenge interval. Attempts were made to passively transfer immunity from immunized C57BL/6 mice which had survived lymphoma challenge to non-treated, syngeneic mice. The route of immunization in the donors influenced the success of passively transferred immunity in the recipients. Serum from days 1 to 3 and days 11 to death (day 17) had an enhancing effect on lymphoma growth. However, sera from days 5 to 9 retarded lymphoma growth. The C57BL/6 lymphoma cells were injected into rabbits and other strains of mice to demonstrate tumor specificity. The lymphoma did not grow in rabbits and only grew in one mouse strain. This strain had the same major histocompatibility loci as C57BL/6 mice. Crosses were made between C57BL/6 mice and a resistant strain of mice (DBA/2 mice). The F 1 hybrids were found to be less susceptible to the lymphoma than the C57BL/6 strain. Sublethal x-irradiation of the F 1 mice decreased its ability to resist the C57BL/6 lymphoma. Immunization with x-ray inactivated C57BL/6 lymphoma cells increased survival after challenge with lymphoma in the F 1 mice

Opening of material analysis beamline (BL-5) at NewSUBARU for industrial enterprises

International Nuclear Information System (INIS)

Hasegawa, Takayuki; Uemura, Masaharu; Tsurui, Takafumi; Shimizu, Masayoshi; Amemiya, Kenta; Fukushima, Sei; Ohta, Toshiaki; Motoyama, Muneyuki; Kanda, Kazuhiro

2010-01-01

A material analysis beamline for the industrial enterprises' use was completed at BL-5 of NewSUBARU synchrotron radiation facility in University of Hyogo in March 2008. BL-5 consists of two branch lines, one is a double crystal monochromator beamline (BL-5A) for the use in the higher-energy region (1300-4000 eV) and the other is a varied line spacing plane grating (VLSPG) monochromator beamline (BL-5B) for the use in the lower-energy region (50-1300 eV). These two branch lines can be operated simultaneously. BL-5 covers the soft X-ray region from 50 to 4000 eV and X-ray absorption spectrum can be measured with a high-energy resolution. The XAFS measurements in the total electron yield (TEY) and fluorescence yield (FLY) can be performed at BL-5A and BL-5B. In addition, the XPS spectra can be measured at BL-5B. BL-5 will be managed and maintained by the Synchrotron Analysis L.L.C. (SALLC), which is composed of the industrial companies, in cooperation with the staffs of the Laboratory of Advanced Science and Technology for Industry in University of Hyogo. Industrial users can be assisted by staffs of SALLC in the measurement at BL-5. (author)

The B-L phase transition. Implications for cosmology and neutrinos

International Nuclear Information System (INIS)

Schmitz, Kai

2012-07-01

We investigate the possibility that the hot thermal phase of the early universe is ignited in consequence of the B-L phase transition, which represents the cosmological realization of the spontaneous breaking of the Abelian gauge symmetry associated with B-L, the difference between baryon number B and lepton number L. Prior to the B-L phase transition, the universe experiences a stage of hybrid inflation. Towards the end of inflation, the false vacuum of unbroken B-L symmetry decays, which entails tachyonic preheating as well as the production of cosmic strings. Observational constraints on this scenario require the B-L phase transition to take place at the scale of grand unification. The dynamics of the B-L breaking Higgs field and the B-L gauge degrees of freedom, in combination with thermal processes, generate an abundance of heavy (s)neutrinos. These (s)neutrinos decay into radiation, thereby reheating the universe, generating the baryon asymmetry of the universe and setting the stage for the thermal production of gravitinos. The B-L phase transition along with the (s)neutrino-driven reheating process hence represents an intriguing and testable mechanism to generate the initial conditions of the hot early universe. We study the B-L phase transition in the full supersymmetric Abelian Higgs model, for which we derive and discuss the Lagrangian in arbitrary and unitary gauge. As for the subsequent reheating process, we formulate the complete set of Boltzmann equations, the solutions of which enable us to give a detailed and time-resolved description of the evolution of all particle abundances during reheating. Assuming the gravitino to be the lightest superparticle (LSP), the requirement of consistency between hybrid inflation, leptogenesis and gravitino dark matter implies relations between neutrino parameters and superparticle masses, in particular a lower bound on the gravitino mass of 10GeV. As an alternative to gravitino dark matter, we consider the case of

The B-L phase transition. Implications for cosmology and neutrinos

Energy Technology Data Exchange (ETDEWEB)

Schmitz, Kai

2012-07-15

We investigate the possibility that the hot thermal phase of the early universe is ignited in consequence of the B-L phase transition, which represents the cosmological realization of the spontaneous breaking of the Abelian gauge symmetry associated with B-L, the difference between baryon number B and lepton number L. Prior to the B-L phase transition, the universe experiences a stage of hybrid inflation. Towards the end of inflation, the false vacuum of unbroken B-L symmetry decays, which entails tachyonic preheating as well as the production of cosmic strings. Observational constraints on this scenario require the B-L phase transition to take place at the scale of grand unification. The dynamics of the B-L breaking Higgs field and the B-L gauge degrees of freedom, in combination with thermal processes, generate an abundance of heavy (s)neutrinos. These (s)neutrinos decay into radiation, thereby reheating the universe, generating the baryon asymmetry of the universe and setting the stage for the thermal production of gravitinos. The B-L phase transition along with the (s)neutrino-driven reheating process hence represents an intriguing and testable mechanism to generate the initial conditions of the hot early universe. We study the B-L phase transition in the full supersymmetric Abelian Higgs model, for which we derive and discuss the Lagrangian in arbitrary and unitary gauge. As for the subsequent reheating process, we formulate the complete set of Boltzmann equations, the solutions of which enable us to give a detailed and time-resolved description of the evolution of all particle abundances during reheating. Assuming the gravitino to be the lightest superparticle (LSP), the requirement of consistency between hybrid inflation, leptogenesis and gravitino dark matter implies relations between neutrino parameters and superparticle masses, in particular a lower bound on the gravitino mass of 10GeV. As an alternative to gravitino dark matter, we consider the case of

Water Vapor, Temperature, and Ice Particles in Polar Mesosphere as Measured by SABER/TIMED and OSIRIS/Odin Instruments

Science.gov (United States)

Feofilov, A. G.; Petelina, S. V.; Kutepov, A. A.; Pesnell, W. D.; Goldberg, R. A.

2009-01-01

Although many new details on the properties of mesospheric ice particles that farm Polar Mesospheric Clouds (PMCs) and also cause polar mesospheric summer echoes have been recently revealed, certain aspects of mesospheric ice microphysics and dynamics still remain open. The detailed relation between PMC parameters and properties of their environment, as well as interseasonal and interhemispheric differences and trends in PMC properties that are possibly related to global change, are among those open questions. In this work, mesospheric temperature and water vapor concentration measured by the Sounding of the Atmosphere using Broadband Emission Radiometry (SABER) instrument on board the Thermosphere Ionosphere Mesosphere Energetics and Dynamics (TIMED) satellite are used to study the properties of PMCs with respect to the surrounding atmosphere. The cloud parameters, namely location, brightness, and altitude, are obtained from the observations made by the Optical Spectrograph and Infrared Imager System (OSIRIS) on the Odin satellite. About a thousand of simultaneous common volume measurements made by SABER and OSIRIS in both hemispheres from 2002 until 2008 are used. The correlation between PMC brightness (and occurrence rate) and temperatures at PMC altitudes and at the mesopause is analysed. The relation between PMC parameters, frost point temperature, and gaseous water vapor content in and below the cloud is also discussed. Interseasonal and interhemispheric differences and trends in the above parameters, as well as in PMC peak altitudes and mesopause altitudes are evaluated.

blé et seigle

African Journals Online (AJOL)

SARAH

hétérochromatine (séquences d'ADN non codante et riches en bases CG) des génomes d'un triticale primaire et leurs géniteurs, blé tendre et seigle d'une part, d'autre part de localiser les régions organisateurs nucléolaires (N.O.R) , les ...

Blæksprutter beskyttes på niveau med hvirveldyr

DEFF Research Database (Denmark)

Alstrup, Aage Kristian Olsen

2015-01-01

beskyttede. Et af de bedst studerede hvirvelløse dyr er blæksprutten, navnlig Octopus vulgaris. Vores viden om nerveimpulsen udbredelse stammer netop fra blæksprutter, da de har meget store nerveceller, der let lader sig undersøge. De to forskere fik faktisk Nobelprisen i 1963 for opdagelsen. Siden da har...

The gravitational wave spectrum from cosmological B-L breaking

International Nuclear Information System (INIS)

Buchmueller, W.; Domcke, V.; Kamada, K.; Schmitz, K.

2013-05-01

Cosmological B-L breaking is a natural and testable mechanism to generate the initial conditions of the hot early universe. If B-L is broken at the grand unification scale, the false vacuum phase drives hybrid inflation, ending in tachyonic preheating. The decays of heavy B-L Higgs bosons and heavy neutrinos generate entropy, baryon asymmetry and dark matter and also control the reheating temperature. The different phases in the transition from inflation to the radiation dominated phase produce a characteristic spectrum of gravitational waves. We calculate the complete gravitational wave spectrum due to inflation, preheating and cosmic strings, which turns out to have several features. The production of gravitational waves from cosmic strings has large uncertainties, with lower and upper bounds provided by Abelian Higgs strings and Nambu-Goto strings, implying Ω GW h 2 ∝10 -13 -10 -8 , much larger than the spectral amplitude predicted by inflation. Forthcoming gravitational wave detectors such as eLISA, advanced LIGO and BBO/DECIGO will reach the sensitivity needed to test the predictions from cosmological B-L breaking.

The gravitational wave spectrum from cosmological B-L breaking

Energy Technology Data Exchange (ETDEWEB)

Buchmueller, W.; Domcke, V.; Kamada, K. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Schmitz, K. [Tokyo Univ., Kashiwa (Japan). Kavli IPMU (WPI)

2013-05-15

Cosmological B-L breaking is a natural and testable mechanism to generate the initial conditions of the hot early universe. If B-L is broken at the grand unification scale, the false vacuum phase drives hybrid inflation, ending in tachyonic preheating. The decays of heavy B-L Higgs bosons and heavy neutrinos generate entropy, baryon asymmetry and dark matter and also control the reheating temperature. The different phases in the transition from inflation to the radiation dominated phase produce a characteristic spectrum of gravitational waves. We calculate the complete gravitational wave spectrum due to inflation, preheating and cosmic strings, which turns out to have several features. The production of gravitational waves from cosmic strings has large uncertainties, with lower and upper bounds provided by Abelian Higgs strings and Nambu-Goto strings, implying {Omega}{sub GW}h{sup 2}{proportional_to}10{sup -13}-10{sup -8}, much larger than the spectral amplitude predicted by inflation. Forthcoming gravitational wave detectors such as eLISA, advanced LIGO and BBO/DECIGO will reach the sensitivity needed to test the predictions from cosmological B-L breaking.

Evolutionary behaviour of AGN: Investigations on BL Lac objects and Seyfert II galaxies

Science.gov (United States)

Beckmann, V.

2000-12-01

The evolution and nature of AGN is still one of the enigmatic questions in astrophysics. While large and complete Quasar samples are available, special classes of AGN, like BL Lac objects and Seyfert II galaxies, are still rare objects. In this work I present two new AGN samples. The first one is the HRX-BL Lac survey, resulting in a sample of X-ray selected BL Lac objects. This sample results from 223 BL Lac candidates based on a correlation of X-ray sources with radio sources. The identification of this sample is 98% complete. 77 objects have been identified as BL Lac objects and form the HRX-BL Lac complete sample, the largest homogeneous sample of BL Lac objects existing today. For this sample, redshifts are now known for 62 objects (81 %). In total I present 101 BL Lac objects in the enlarged HRX-BL Lac survey, for which redshift information is available for 84 objects. During the HRX-BL Lac survey I found several objects of special interest. 1ES 1517+656 turned out to be the brightest known BL Lac object in the universe. 1ES 0927+500 could be the first BL Lac object with a line detected in the X-ray region. RX J1211+2242 is probably the the counterpart of the up to now unidentified gamma-ray source 3EG J1212+2304. Additionally I present seven candidates for ultra high frequency peaked BL Lac objects. RX J1054+3855 and RX J1153+3517 are rare high redshift X-ray bright QSO or accreting binary systems with huge magnetic fields. For the BL Lac objects I suggest an unified scenario in which giant elliptical galaxies, formed by merging events of spiral galaxies at z > 2, start as powerful, radio dominated BL Lacs. As the jet gets less powerful, the BL Lacs start to get more X-ray dominated, showing less total luminosities (for z definition to objects with a calcium break up to 40%, but do not support for the HBL the idea of allowing emission lines in the spectra of BL Lac galaxies. A way to find high redshift BL Lac objects might be the identification of faint X

Den Blå Drage

DEFF Research Database (Denmark)

Ingerslev, Gitte Holten

Denne publikation i serien Læselyst tjener tre formål. Den evaluerer læseprojektet Den blå drage i efteråret 2004 på Byskolen i Svendborg ? et projekt ledet af forfatteren Josefine Ottesen. Desuden gøres der rede for nogle af de teorier der støtter og begrunder arbejdsmåde og resultater i projektet...

Infrared polarimetry and photometry of BL Lac objects

Energy Technology Data Exchange (ETDEWEB)

Impey, C D; Brand, P W.J.L. [Edinburgh Univ. (UK); Wolstencroft, R D; Williams, P M [Royal Observatory, Edinburgh (UK)

1982-07-01

Infrared polarimetry and photometry have been obtained for a sample of 18 BL Lac objects. The data covers a period of one year and is part of a continuing monitoring programme; all observations were in the J,H and K wavebands. Large and variable degrees of polarization are a common property of the sample. Two BL Lac objects show wavelength-dependent polarization, with the polarization increasing towards shorter wavelengths, and two objects show evidence for position angle rotations over a five-day period. The relationship between changes in polarized and total flux is also discussed. The BL Lac objects cover an enormous range of infrared luminosity; the three most luminous having Lsub(IR) > 10/sup 46/ erg s/sup -1/ and the other end of the range having infrared luminosities similar to normal elliptical galaxies. These are the first published infrared polarimetric observations for eight of the sample.

ASCA and Contemporaneous Ground-based Observations of the BL Lacertae Objects 1749+096 and 2200+420 (BL Lac)

International Nuclear Information System (INIS)

Sambruna, R.M.; Ghisellini, G.; Hooper, E.; Kollgaard, R.I.; Pesce, J.E.; Urry, C.M.

1999-01-01

We present ASCA observations of the radio-selected BL Lacertae objects 1749+096 (z=0.32) and 2200+420 (BL Lac, z=0.069) performed in 1995 September and November, respectively. The ASCA spectra of both sources can be described as a first approximation by a power law with photon index Γ∼2. This is flatter than for most X-ray endash selected BL Lacs observed with ASCA, in agreement with the predictions of current blazar unification models. While 1749+096 exhibits tentative evidence for spectral flattening at low energies, a concave continuum is detected for 2200+420: the steep low-energy component is consistent with the high-energy tail of the synchrotron emission responsible for the longer wavelengths, while the harder tail at higher energies is the onset of the Compton component. The two BL Lacs were observed with ground-based telescopes from radio to TeV energies contemporaneously with ASCA. The spectral energy distributions are consistent with synchrotron self-Compton emission from a single homogeneous region shortward of the IR/optical wavelengths, with a second component in the radio domain related to a more extended emission region. For 2200+420, comparing the 1995 November state with the optical/GeV flare of 1997 July, we find that models requiring inverse Compton scattering of external photons provide a viable mechanism for the production of the highest (GeV) energies during the flare. In particular, an increase of the external radiation density and of the power injected in the jet can reproduce the flat γ-ray continuum observed in 1997 July. A directly testable prediction of this model is that the line luminosity in 2200+420 should vary shortly after (∼1 month) a nonthermal synchrotron flare. copyright copyright 1999. The American Astronomical Society

Multi-Band Intra-Night Optical Variability of BL Lacertae

Directory of Open Access Journals (Sweden)

Haritma Gaur

2017-12-01

Full Text Available We monitored BL Lacertae frequently during 2014–2016 when it was generally in a high state. We searched for intra-day variability for 43 nights using quasi-simultaneous measurements in the B, V, R, and I bands (totaling 143 light curves; the typical sampling interval was about eight minutes. On hour-like timescales, BL Lac exhibited significant variations during 13 nights in various optical bands. Significant spectral variations are seen during most of these nights such that the optical spectrum becomes bluer when brighter. The amplitude of variability is usually greater for longer observations but is lower when BL Lac is brighter. No evidence for periodicities or characteristic variability time-scales in the light curves was found. The color variations are mildly chromatic on long timescales.

Flat radio-spectrum galaxies and BL Lacs I. Core properties

NARCIS (Netherlands)

Dennett-Thorpe, J; Marcha, MJ

This paper concerns the relationship of BL Lacs and flat-spectrum weak emission-line galaxies. We compare the weak emission-line galaxies and the BL Lacs in a sample of 57 flat-spectrum objects (Marcha et al. 1996), using high-frequency radio and non-thermal optical flux densities, spectral indices

Probiotic Strain Lactobacillus casei BL23 Prevents Colitis-Associated Colorectal Cancer

Directory of Open Access Journals (Sweden)

Elsa Jacouton

2017-11-01

Full Text Available The gut microbiota plays a major role in intestinal health, and an imbalance in its composition can lead to chronic gut inflammation and a predisposition to developing colorectal cancer (CRC. Currently, the use of probiotic bacteria represents an emerging alternative to treat and prevent cancer. Moreover, consumption of these beneficial bacteria may also favorably modulate the composition of the gut microbiota, which has been described in several studies to play an important role in CRC carcinogenesis. In this context, the aim of this study was to assess the protective effect of oral treatment with Lactobacillus casei BL23, a probiotic strain well known for its anti-inflammatory and anticancer properties. First, CRC was induced in C57BL6 mice by a single intraperitoneal injection with azoxymethane (8 mg/kg, followed by four courses of dextran sodium sulfate (2.5% in drinking water that were separated by an adjustable recovery period. At the time of sacrifice (day 46, tumor incidence, histological scores, and epithelial proliferation were determined in colon samples. Our results show that L. casei BL23 significantly protected mice against CRC development; specifically, L. casei BL23 treatment reduced histological scores and proliferative index values. In addition, our analysis revealed that L. casei BL23 had an immunomodulatory effect, mediated through the downregulation of the IL-22 cytokine, and an antiproliferative effect, mediated through the upregulation of caspase-7, caspase-9, and Bik. Finally, L. casei BL23 treatment tended to counterbalance CRC-induced dysbiosis in mice, as demonstrated by an analysis of fecal microbiota. Altogether our results demonstrate the high potential of L. casei BL23 for the development of new, probiotic-based strategies to fight CRC.

Von Blüten, Göttern und Gelehrten

OpenAIRE

Zotter, Astrid

2013-01-01

Der Sanskrittext Puṣpacintāmaṇi (PuCi) behandelt Blüten als Darbringungen (upacāra) im wichtigsten hinduistischen Verehrungsritual, der pūjā. In ca. 400 Strophen werden über 200 Namen von Blüten genannt und für verschiedene Gottheiten und pūjās als geeignete oder ungeeignete Gaben vorgeschrieben. Der Text ist eine Kompilation (Nibandha), in der die Inhalte aus 47 namentlich genannten Quellentexten referiert werden. Ziel der Dissertation ist es nicht nur, diesen Text, der 1966 zum ersten Ma...

Optical Spectra Evolution of BL Lac Objects XW Bi1,∗ , BZ Wang2

Indian Academy of Sciences (India)

low-frequency peaked BL Lac objects (LBLs) is steeper than the high- frequency peaked BL Lac ... vision of BL Lac objects. Many investigators .... We are grateful to the Scientific Research Foundation of the Education Department of Yunnan ...

The B-L scotogenic models for Dirac neutrino masses

Science.gov (United States)

Wang, Weijian; Wang, Ruihong; Han, Zhi-Long; Han, Jin-Zhong

2017-12-01

We construct the one-loop and two-loop scotogenic models for Dirac neutrino mass generation in the context of U(1)_{B-L} extensions of standard model. It is indicated that the total number of intermediate fermion singlets is uniquely fixed by the anomaly free condition and the new particles may have exotic B-L charges so that the direct SM Yukawa mass term \\bar{ν }_Lν _R\\overline{φ ^0} and the Majorana mass term (m_N/2)\\overline{ν _R^C}ν _R are naturally forbidden. After the spontaneous breaking of the U(1)_{B-L} symmetry, the discrete Z2 or Z3 symmetry appears as the residual symmetry and gives rise to the stability of intermediate fields as DM candidates. Phenomenological aspects of lepton flavor violation, DM, leptogenesis and LHC signatures are discussed.

The Radio-optical Spectra of BL Lacs and Possible Relatives

Science.gov (United States)

Dennett-Thorpe, J.

I consider the suggestion that, in a complete sample of flat-spectrum radio sources with available optical spectra (Marcha et al 1996), the strong emission line objects, or those with passive elliptical spectra are close relatives of the BL Lacs. New observations at four frequencies from 8 to 43GHz are presented, together with evidence for radio variability. Combined with other radio and optical data from the literature, we are able to construct the non-thermal SEDs and use these to address the questions: are the optically passive objects potentially `unrecognised' BL Lacs (either intrinsically weak and/or hidden by starlight)? What is the relationship between the surprising number of strong emission-line objects and the BL Lacs?

Efficacy of convenience sampling through the internet versus respondent driven sampling among males who have sex with males in Tallinn and Harju County, Estonia: challenges reaching a hidden population.

Science.gov (United States)

Johnston, Lisa Grazina; Trummal, Aire; Lohmus, Liilia; Ravalepik, Ardi

2009-09-01

This paper examines challenges obtaining representative samples of males who have sex with males (MSM) in Estonia and provides descriptive HIV behavioral data gathered from four cross-sectional surveys; three using the internet, and one using respondent driven sampling (RDS) to recruit MSM in Tallinn and Harju County. Estonian MSM were sampled between March and May in 2004 (n=193), August and November in 2005 (n=146) and September and December in 2007 (n=238) using internet websites. MSM in Tallinn and Harju County were sampled between April and June in 2007 (n=59) using RDS. Recruitment of MSM using RDS did not acquire the calculated sample size. The RDS study reached a less diverse group of MSM than did the internet studies which recruited a larger proportion of MSM who were older, bisexual, having female sexual partners during the last six months, and unlikely to have been tested for HIV. The findings and observations presented in this paper could inform researchers in Estonia, and the region, about the efficacy of and socio-cultural challenges to sampling MSM to collect HIV biological and/or behavioral data.

The REX survey as a Tool to Test the Beaming Model for BL Lacs

Science.gov (United States)

Caccianiga, A.; della Ceca, R.; Gioia, I. M.; Maccacaro, T.; Wolter, A.

We present the preliminary properties of the BL Lacs discovered in the REX survey (Caccianiga et al. 1998). In particular, we discuss a few sources with optical spectral properties ``intermediate'' between those of BL Lacs and those of elliptical galaxies. These objects could harbour weak (in the optical band) sources of non-thermal continuum in their nuclei and, if confirmed, they could represent the faint tail of the BL Lac population. The existence of such ``weak'' BL Lacs is matter of discussion in recent literature (e.g. Marcha et al. 1996) and could lead to a revision of the defining criteria of a BL Lac and, consequently, of their cosmological and statistical properties.

Thermostable Bacteriocin BL8 from Bacillus licheniformis isolated from marine sediment.

Science.gov (United States)

Smitha, S; Bhat, S G

2013-03-01

To isolate and characterize bacteriocin, BL8, from the bacteria identified as Bacillus licheniformis from marine environment. One-hundred and twelve bacterial isolates from sediment and water samples collected off the coast of Cochin, India, were screened for antibacterial activity. Strain BTHT8, identified as Bacillus licheniformis, inhibited the growth of Gram-positive test organisms. The active component labelled as bacteriocin BL8 was partially purified by ammonium sulphate fractionation and was subjected to glycine SDS-PAGE. The band exhibiting antimicrobial activity was electroeluted and analysed using MALDI-TOF mass spectrometry, and the molecular mass was determined as 1.4 kDa. N-terminal amino acid sequencing of BL8 gave a 13 amino acid sequence stretch. Bacteriocin BL8 was stable even after boiling at 100 °C for 30 min and over a wide pH range of 1-12. A novel, pH-tolerant and thermostable bacteriocin BL8, active against the tested Gram-positive bacteria, was isolated from Bacillus licheniformis. This study reports a stable, low molecular weight bacteriocin from Bacillus licheniformis. This bacteriocin can be used to address two important applications: as a therapeutic agent and as a biopreservative in food processing industry. © 2012 The Society for Applied Microbiology.

Making limb and nadir measurements comparable: A common volume study of PMC brightness observed by Odin OSIRIS and AIM CIPS

Science.gov (United States)

Benze, Susanne; Gumbel, Jörg; Randall, Cora E.; Karlsson, Bodil; Hultgren, Kristoffer; Lumpe, Jerry D.; Baumgarten, Gerd

2018-01-01

Combining limb and nadir satellite observations of Polar Mesospheric Clouds (PMCs) has long been recognized as problematic due to differences in observation geometry, scattering conditions, and retrieval approaches. This study offers a method of comparing PMC brightness observations from the nadir-viewing Aeronomy of Ice in the Mesosphere (AIM) Cloud Imaging and Particle Size (CIPS) instrument and the limb-viewing Odin Optical Spectrograph and InfraRed Imaging System (OSIRIS). OSIRIS and CIPS measurements are made comparable by defining a common volume for overlapping OSIRIS and CIPS observations for two northern hemisphere (NH) PMC seasons: NH08 and NH09. We define a scattering intensity quantity that is suitable for either nadir or limb observations and for different scattering conditions. A known CIPS bias is applied, differences in instrument sensitivity are analyzed and taken into account, and effects of cloud inhomogeneity and common volume definition on the comparison are discussed. Not accounting for instrument sensitivity differences or inhomogeneities in the PMC field, the mean relative difference in cloud brightness (CIPS - OSIRIS) is -102 ± 55%. The differences are largest for coincidences with very inhomogeneous clouds that are dominated by pixels that CIPS reports as non-cloud points. Removing these coincidences, the mean relative difference in cloud brightness reduces to -6 ± 14%. The correlation coefficient between the CIPS and OSIRIS measurements of PMC brightness variations in space and time is remarkably high, at 0.94. Overall, the comparison shows excellent agreement despite different retrieval approaches and observation geometries.

RADIO-WEAK BL LAC OBJECTS IN THE FERMI ERA

Energy Technology Data Exchange (ETDEWEB)

Massaro, F.; Marchesini, E. J. [Dipartimento di Fisica, Università degli Studi di Torino (UniTO), via Pietro Giuria 1, I-10125 Torino (Italy); D’Abrusco, R.; Smith, Howard A. [Smithsonian Astrophysical Observatory, 60 Garden Street, 02138 Cambridge, MA (United States); Masetti, N. [INAF—Istituto di Astrofisica Spaziale e Fisica Cosmica di Bologna, via Gobetti 101, I-40129, Bologna (Italy); Andruchow, I. [Facultad de Ciencias Astronómicas y Geofísicas, Universidad Nacional de La Plata, Paseo del Bosque, B1900FWA, La Plata (Argentina)

2017-01-10

The existence of “radio-weak BL Lac objects” (RWBLs) has been an open question, and has remained unsolved since the discovery that quasars could be radio-quiet or radio-loud. Recently, several groups identified RWBL candidates, mostly found while searching for low-energy counterparts of the unidentified or unassociated gamma-ray sources listed in the Fermi catalogs. Confirming RWBLs is a challenging task since they could be confused with white dwarfs (WDs) or weak emission line quasars (WELQs) when there are not sufficient data to precisely draw their broadband spectral energy distribution, and their classification is mainly based on a featureless optical spectra. Motivated by the recent discovery that Fermi BL Lacs appear to have very peculiar mid-IR emission, we show that it is possible to distinguish between WDs, WELQs, and BL Lacs using the [3.4]–[4.6]–[12] μ m color–color plot built using the WISE magnitudes when the optical spectrum is available. On the basis of this analysis, we identify WISE J064459.38+603131 and WISE J141046.00+740511.2 as the first two genuine RWBLs, both potentially associated with Fermi sources. Finally, to strengthen our identification of these objects as true RWBLs, we present multifrequency observations for these two candidates to show that their spectral behavior is indeed consistent with that of the BL Lac population.

RADIO-WEAK BL LAC OBJECTS IN THE FERMI ERA

International Nuclear Information System (INIS)

Massaro, F.; Marchesini, E. J.; D’Abrusco, R.; Smith, Howard A.; Masetti, N.; Andruchow, I.

2017-01-01

The existence of “radio-weak BL Lac objects” (RWBLs) has been an open question, and has remained unsolved since the discovery that quasars could be radio-quiet or radio-loud. Recently, several groups identified RWBL candidates, mostly found while searching for low-energy counterparts of the unidentified or unassociated gamma-ray sources listed in the Fermi catalogs. Confirming RWBLs is a challenging task since they could be confused with white dwarfs (WDs) or weak emission line quasars (WELQs) when there are not sufficient data to precisely draw their broadband spectral energy distribution, and their classification is mainly based on a featureless optical spectra. Motivated by the recent discovery that Fermi BL Lacs appear to have very peculiar mid-IR emission, we show that it is possible to distinguish between WDs, WELQs, and BL Lacs using the [3.4]–[4.6]–[12] μ m color–color plot built using the WISE magnitudes when the optical spectrum is available. On the basis of this analysis, we identify WISE J064459.38+603131 and WISE J141046.00+740511.2 as the first two genuine RWBLs, both potentially associated with Fermi sources. Finally, to strengthen our identification of these objects as true RWBLs, we present multifrequency observations for these two candidates to show that their spectral behavior is indeed consistent with that of the BL Lac population.

(M,N-Soft Intersection BL-Algebras and Their Congruences

Directory of Open Access Journals (Sweden)

Xueling Ma

2014-01-01

Full Text Available The purpose of this paper is to give a foundation for providing a new soft algebraic tool in considering many problems containing uncertainties. In order to provide these new soft algebraic structures, we discuss a new soft set-(M, N-soft intersection set, which is a generalization of soft intersection sets. We introduce the concepts of (M, N-SI filters of BL-algebras and establish some characterizations. Especially, (M, N-soft congruences in BL-algebras are concerned.

Gene expression profiling in response to the histone deacetylase inhibitor BL1521 in neuroblastoma

International Nuclear Information System (INIS)

Ruijter, Annemieke J.M. de; Meinsma, Rutger J.; Bosma, Peter; Kemp, Stephan; Caron, Huib N.; Kuilenburg, Andre B.P. van

2005-01-01

Neuroblastoma is a childhood tumor with a poor survival in advanced stage disease despite intensive chemotherapeutic regimes. The new histone deacetylase (HDAC) inhibitor BL1521 has shown promising results in neuroblastoma. Inhibition of HDAC resulted in a decrease in proliferation and metabolic activity, induction of apoptosis and differentiation of neuroblastoma cells. In order to elucidate the mechanism mediating the effects of BL1521 on neuroblastoma cells, we investigated the gene expression profile of an MYCN single copy (SKNAS) and an MYCN amplified (IMR32) neuroblastoma cell line after treatment with BL1521 using the Affymetrix oligonucleotide array U133A. An altered expression of 255 genes was observed in both neuroblastoma cell lines. The majority of these genes were involved in gene expression, cellular metabolism, and cell signaling. We observed changes in the expression of vital genes belonging to the cell cycle (cyclin D1 and CDK4) and apoptosis (BNIP3, BID, and BCL2) pathway in response to BL1521. The expression of 37 genes was altered by both BL1521 and Trichostatin A, which could indicate a common gene set regulated by different HDAC inhibitors. BL1521 treatment changed the expression of a number of MYCN-associated genes. Several genes in the Wnt and the Delta/Notch pathways were changed in response to BL1521 treatment, suggesting that BL1521 is able to induce the differentiation of neuroblastoma cells into a more mature phenotype

B-L violating supersymmetric couplings

International Nuclear Information System (INIS)

Ramond, P.

1983-01-01

We consider two problems: one is the possible effect of the breaking of Peccei-Quinn symmetry on the inflationary universe scenario; the other is the remark that even the minimal supersymmetric SU 5 theory contains B-L violating couplings which give rise to neutrino masses and family-diagonal proton decay. However the strength of these couplings is limited by the gauge hierarchy

Time-dependent inhomogeneous jet models for BL Lac objects

Science.gov (United States)

Marlowe, A. T.; Urry, C. M.; George, I. M.

1992-05-01

Relativistic beaming can explain many of the observed properties of BL Lac objects (e.g., rapid variability, high polarization, etc.). In particular, the broadband radio through X-ray spectra are well modeled by synchrotron-self Compton emission from an inhomogeneous relativistic jet. We have done a uniform analysis on several BL Lac objects using a simple but plausible inhomogeneous jet model. For all objects, we found that the assumed power-law distribution of the magnetic field and the electron density can be adjusted to match the observed BL Lac spectrum. While such models are typically unconstrained, consideration of spectral variability strongly restricts the allowed parameters, although to date the sampling has generally been too sparse to constrain the current models effectively. We investigate the time evolution of the inhomogeneous jet model for a simple perturbation propagating along the jet. The implications of this time evolution model and its relevance to observed data are discussed.

Properties of optically selected BL Lacertae candidates from the SDSS

Science.gov (United States)

Kügler, S. D.; Nilsson, K.; Heidt, J.; Esser, J.; Schultz, T.

2014-09-01

Context. Deep optical surveys open the avenue for finding large numbers of BL Lac objects that are hard to identify because they lack the unique properties classifying them as such. While radio or X-ray surveys typically reveal dozens of sources, recent compilations based on optical criteria alone have increased the number of BL Lac candidates considerably. However, these compilations are subject to biases and may contain a substantial number of contaminating sources. Aims: In this paper we extend our analysis of 182 optically selected BL Lac object candidates from the SDSS with respect to an earlier study. The main goal is to determine the number of bona fide BL Lac objects in this sample. Methods: We examine their variability characteristics, determine their broad-band radio-UV spectral energy distributions (SEDs), and search for the presence of a host galaxy. In addition we present new optical spectra for 27 targets with improved signal-to-noise ratio with respect to the SDSS spectra. Results: At least 59% of our targets have shown variability between SDSS DR2 and our observations by more than 0.1-0.27 mag depending on the telescope used. A host galaxy was detected in 36% of our targets. The host galaxy type and luminosities are consistent with earlier studies of BL Lac host galaxies. Simple fits to broad-band SEDs for 104 targets of our sample derived synchrotron peak frequencies between 13.5 ≤ log 10(νpeak) ≤ 16 with a peak at log 10 ~ 14.5. Our new optical spectra do not reveal any new redshift for any of our objects. Thus the sample contains a large number of bona fide BL Lac objects and seems to contain a substantial fraction of intermediate-frequency peaked BL Lacs. Based on observations collected with the NTT on La Silla (Chile) operated by the European Southern Observatory under proposal 082.B-0133.Based on observations collected at the Centro Astronómico Hispano Alemán (CAHA), operated jointly by the Max-Planck-Institut für Astronomie and the

Fatal traffic injuries among children and adolescents in three cities (capital Budapest, Vilnius, and Tallinn).

Science.gov (United States)

Töro, Klára; Szilvia, Fehér; György, Dunay; Pauliukevicius, Alvydas; Caplinskiene, Marija; Raudys, Romas; Lepik, Delia; Tuusov, Jana; Vali, Marika

2011-05-01

Motor vehicle accidental injuries are a frequent cause of death among young children and adolescents. The goal of this study was to compare patterns of injury between three capitals (Budapest, Vilnius, and Tallinn). Information on 190 fatal traffic accidents (69 pedestrians, 14 bicyclists, and 107 motor vehicle occupants) between 2002 and 2006 was collected from databases of medico-legal autopsies. The role of victims in accidents, the location of injuries, cause of death, survival period, and blood alcohol levels were evaluated. One-hundred and forty-one (74%) victims had a passive role in traffic as pedestrians, passengers in cars, or public transport. In victims who died at the scene, the rate of head injury was higher than in cases who received medical treatment (odds ratio = 2.58, CI = 1.2-5.55, p = 0.0127). These results underline the importance of postmortem studies to examine the pathomechanism of fatal traffic accidental injuries and to provide information for the prevention of road traffic accidents against children and adolescents. © 2011 American Academy of Forensic Sciences.

Optical polarimetry of quasi-stellar and BL Lac objects

International Nuclear Information System (INIS)

Wills, D.; Wills, B.J.; Breger, M.; Hsu, J.

1980-01-01

We report observations of 39 extragalactic objects, using a new polarimeter at McDonald Observatory. Most of the observations were made in January and June 1980. Some new BL Lac objects were found, and some of the previously known members of this class were also observed. Polarization exceeding 3--4 times the formal rms uncertainties was found in about ten QSO's. Rapid changes of polarization and/or position angle occurred in some of the BL Lacertae objects, usually with <0.1-mag change in the total light

Highlights of SPring-8 BL23SU in 2001

CERN Document Server

Agui, A; Nakatani, T; Yokoya, A; Yoshigoe, A

2002-01-01

BL23SU in SPring-8 is a soft x-ray beamline for the material science project in JAERI. The insertion device, monochromator and other beamline equipments have been installed or developed. The beamline maintenance has also been continued. We report highlights of these activities for the BL23SU in 2001. Specially, it has proceeded with the countermeasure against the rise in the maximum radiant power, toward the low-energy operation realization. And, improvement in that precision proceeds through the COD correlation to the ID drive as well.

Majorana dark matter with B+L gauge symmetry

Energy Technology Data Exchange (ETDEWEB)

Chao, Wei [Amherst Center for Fundamental Interactions, Department of Physics,University of Massachusetts-Amherst,Amherst, MA 01003 United States (United States); Center for Advanced Quantum Studies,Department of Physics, Beijing Normal University,Beijing, 100875 (China); Guo, Huai-Ke [Amherst Center for Fundamental Interactions, Department of Physics,University of Massachusetts-Amherst,Amherst, MA 01003 United States (United States); Zhang, Yongchao [Service de Physique Théorique, Université Libre de Bruxelles,Boulevard du Triomphe, CP225, 1050 Brussels (Belgium)

2017-04-07

We present a new model that extends the Standard Model (SM) with the local B+L symmetry, and point out that the lightest new fermion ζ, introduced to cancel anomalies and stabilized automatically by the B+L symmetry, can serve as the cold dark matter candidate. We study constraints on the model from Higgs measurements, electroweak precision measurements as well as the relic density and direct detections of the dark matter. Numerical results reveal that the pseudo-vector coupling of ζ with Z and the Yukawa coupling with the SM Higgs are highly constrained by the latest results of LUX, while there are viable parameter space that could satisfy all the constraints and give testable predictions.

Studies on emerging radiation leukemia virus variants in C57BL/Ka mice

International Nuclear Information System (INIS)

Rassart, E.; Shang, M.; Boie, Y.; Jolicoeur, P.

1986-01-01

To analyze the emergence of radiation leukemia virus (RadLV) variants in primary X-ray-induced C57BL/Ka thymoma and to identify the virus responsible for the very high leukemogenic potential of passaged Kaplan strain BL/VL3 preparation, we cloned several primary and passaged ecotropic RadLV infectious genomes. By restriction analysis, we found that BL/VL3 cells harbor three related but different ecotropic RadLVs. Their restriction map differs significantly from those of primary RadLVs. Hybridization analysis also indicated that BL/VL3 and primary RadLVs differ in their p15E and long terminal repeat (LTR) regions. The LTR sequence of primary weakly leukemogenic RadLV has only one change, a C-rich sequence, generating a 6-base-pair direct repeat just in front of the promotor. The LTR of the primary nonleukemogenic RadLV only showed few base changes, mainly clustered in R and U5. The LTR from a moderately leukemogenic passaged BL/VL3 RadLV had conserved the C-rich sequence and acquired a 43-base-pair direct repeat in U3 and several other point mutations, small insertions, and deletions scattered in U3, R, and U5. All cloned primary RadLVs were fibrotropic, and some were weakly leukemogenic. All cloned BL/VL3 RadLVs were thymotropic and nonfibrotropic. The block of their replication was found to be after the synthesis of unintegrated linear and supercoiled viral DNA. Most of the BL/VL3 RadLVs were moderately leukemogenic, and one (V-13) was highly leukemogenic, being as virulent as the Moloney strain. We propose a model for the emergence of the RadLV variants and show that the virus responsible for the high leukemogenic potential of BL/VL3 preparation is a nondefective, ecotropic, lymphotropic, nonfibrotropic, unique retrovirus which most likely arose from a parental primary RadLV similar to those studied here

Hydrogeologic Characterization of the U-3bl Collapse Zone

International Nuclear Information System (INIS)

NSTec Geotechnical Services

2006-01-01

The U-3bl collapse crater was formed by an underground nuclear test in August 1962. This crater and the adjoining U-3ax crater were subsequently developed and used as a bulk low-level radioactive waste disposal cell (U-3ax/bl), which is part of the Area 3 Radioactive Waste Management Site at the Nevada Test Site (NTS). Various investigations have been conducted to assess the hydrogeologic characteristics and properties in the vicinity of the U-3ax/bl waste disposal cell. This report presents data from one of these investigations, conducted in 1996. Also included in this report is a review of pertinent nuclear testing records, which shows that the testing operations and hydrogeologic setting of the U-3ax/bl site were typical for the period and location of testing. Borehole U-3bl-D2 is a 45-degree-angle hole drilled from the edge of the crater under the waste cell to intercept the U-3bl collapse zone, the disturbed alluvium between the crater (surface collapse sink) and the nuclear test cavity. A casing-advance system with an air percussion hammer was used to drill the borehole, and air was used as the drilling fluid. Properties of the U-3bl crater collapse zone were determined from cores collected within the interval, 42.1 to 96.6 meters (138 to 317 feet) below the ground surface. Selected core samples were analyzed for particle density, particle size, bulk density, water retention, hydraulic conductivity, water content, water potential, chloride, carbonate, stable isotopes, and tritium. Physical and hydraulic properties were typical of alluvial valley sediments at the NTS. No visual evidence of preferential pathways for water transport was observed in the core samples. Soil parameters showed no trends with depth. Volumetric water content values ranged from 0.08 to 0.20 cubic meters per cubic meter, and tended to increase with depth. Water-retention relations were typical for soils of similar texture. Water potentials ranged from -1.9 MegaPascals at a depth of 42

Multi-Wave Luminosity of High-Synchrotron-Peaked TeV BL Lacs ...

Indian Academy of Sciences (India)

LIR, Lγ) in the radio, near-infrared and γ-ray wave bands for HSP. TeV BL Lacs. The results show that there are significant intrinsic cor- relations between LR and Lγ and between LIR and Lγ in all states. (high/average/low), and suggest that for HSP TeV BL Lacs, the Syn- chrotron Self-Compton radiation (SSC) is the main ...

Asymmetric Gepner models III. B-L lifting

Energy Technology Data Exchange (ETDEWEB)

Gato-Rivera, B. [NIKHEF Theory Group, Kruislaan 409, 1098 SJ Amsterdam (Netherlands); Instituto de Fisica Fundamental, CSIC, Serrano 123, Madrid 28006 (Spain); Schellekens, A.N., E-mail: t58@nikhef.n [NIKHEF Theory Group, Kruislaan 409, 1098 SJ Amsterdam (Netherlands); Instituto de Fisica Fundamental, CSIC, Serrano 123, Madrid 28006 (Spain); IMAPP, Radboud Universiteit, Nijmegen (Netherlands)

2011-06-21

In the same spirit as heterotic weight lifting, B-L lifting is a way of replacing the superfluous and ubiquitous U(1){sub B-L} with something else with the same modular properties, but different conformal weights and ground state dimensions. This method works in principle for all variants of (2,2) constructions, such as orbifolds, Calabi-Yau manifolds, free bosons and fermions and Gepner models, since it only modifies the universal SO(10)xE{sub 8} part of the CFT. However, it can only yield chiral spectra if the 'internal' sector of the theory provides a simple current of order 5. Here we apply this new method to Gepner models. Including exceptional invariants, 86 of them have the required order 5 simple current, and 69 of these yield chiral spectra. Three family spectra occur abundantly.

Multi-wavelength studies of TeV γ-ray emitting BL Lac objects

International Nuclear Information System (INIS)

Kaufmann, Sarah Sabine

2012-01-01

The discovery of TeV γ-ray emission of BL Lac objects gave new insights in the particle acceleration and the emission processes of the highly relativistic jets. To shed light on the conditions in the high energetic jets of the TeV γ-ray emitting BL Lac objects, I have studied in great detail the spectral energy distribution (SED) of sources with different characteristics. BL Lac objects with exceptional very high energy spectra (soft and hard spectra) and with large differences in the emission peak frequencies, to cover the different classes of BL Lac objects, have been chosen. The basic aim of this thesis was, to study with new, simultaneous multi- avelength (MWL) observations, if the emission processes of these extreme cases of TeV BL Lac objects can be explained by the synchrotron Self-Compton (SSC) model which is well established for the class of BL Lac objects at lower energies. We proposed MWL observations in the optical, UV and X-ray regime, to be conducted simultaneous to very high energy observations with the H.E.S.S. experiment, to study the emission processes. Simultaneous observations are crucial, since BL Lac objects are variable at all wavebands. I have analysed the MWL observations and conducted detailed variability and spectral studies in each wavelength range. The different kind of absorption at each wavelength as well as the influence of the host galaxy of the AGN has been considered to obtain the intrinsic jet spectrum. I have then applied the commonly used theoretical jet model, the SSC model, to the SED. I conducted a MWL campaign on a BL Lac object with the softest TeV spectrum, PKS 2005-489, during which it was observed in a very bright X-ray state. The good spectral coverage of the emission peaks allowed a detailed study of the SSC model. The extreme BL Lac object 1ES 0229+200 exhibits a hard intrinsic TeV spectrum. With my MWL campaign I found a clear cut-off in the optical range and therefore a high minimum Lorentz factor is needed to

Multi-wavelength studies of TeV γ-ray emitting BL Lac objects

Energy Technology Data Exchange (ETDEWEB)

Kaufmann, Sarah Sabine

2012-12-21

The discovery of TeV γ-ray emission of BL Lac objects gave new insights in the particle acceleration and the emission processes of the highly relativistic jets. To shed light on the conditions in the high energetic jets of the TeV γ-ray emitting BL Lac objects, I have studied in great detail the spectral energy distribution (SED) of sources with different characteristics. BL Lac objects with exceptional very high energy spectra (soft and hard spectra) and with large differences in the emission peak frequencies, to cover the different classes of BL Lac objects, have been chosen. The basic aim of this thesis was, to study with new, simultaneous multi- avelength (MWL) observations, if the emission processes of these extreme cases of TeV BL Lac objects can be explained by the synchrotron Self-Compton (SSC) model which is well established for the class of BL Lac objects at lower energies. We proposed MWL observations in the optical, UV and X-ray regime, to be conducted simultaneous to very high energy observations with the H.E.S.S. experiment, to study the emission processes. Simultaneous observations are crucial, since BL Lac objects are variable at all wavebands. I have analysed the MWL observations and conducted detailed variability and spectral studies in each wavelength range. The different kind of absorption at each wavelength as well as the influence of the host galaxy of the AGN has been considered to obtain the intrinsic jet spectrum. I have then applied the commonly used theoretical jet model, the SSC model, to the SED. I conducted a MWL campaign on a BL Lac object with the softest TeV spectrum, PKS 2005-489, during which it was observed in a very bright X-ray state. The good spectral coverage of the emission peaks allowed a detailed study of the SSC model. The extreme BL Lac object 1ES 0229+200 exhibits a hard intrinsic TeV spectrum. With my MWL campaign I found a clear cut-off in the optical range and therefore a high minimum Lorentz factor is needed to

THE INFLUENCE OF SOCIAL STATUS AND ETHNICITY ON DIET IN MEDIAEVAL TALLINN AS SEEN THROUGH STABLE ISOTOPE ANALYSIS

DEFF Research Database (Denmark)

Lightfoot, Emma; Naum, Magdalena; Kadakas, Villu

2016-01-01

, for comparative purposes. The individuals were investigated using carbon, nitrogen and oxygen stable isotope analysis. The results indicate that while all analysed individuals consumed diets based on C3 plants and animals consuming C3 plants, some individuals also consumed small amounts of C4 plants (likely......Food encodes social and cultural values and has an important role to play in defining identities. In mixed populations, diet can be used to distinguish between ‘us’ and ‘them’. This study investigates the extent to which the inhabitants of mediaeval Tallinn, an important trading centre, used food...... millet) or seafood. C 4 plants were consumed by the urban residents buried at the Church of the Holy Spirit and one or two individuals from Sulevimägi. It is thought that millet was an imported food consumed by the middle class. Marine foods were consumed by the individuals at St Catherine’s Church...

CNN-BLPred: a Convolutional neural network based predictor for β-Lactamases (BL) and their classes.

Science.gov (United States)

White, Clarence; Ismail, Hamid D; Saigo, Hiroto; Kc, Dukka B

2017-12-28

The β-Lactamase (BL) enzyme family is an important class of enzymes that plays a key role in bacterial resistance to antibiotics. As the newly identified number of BL enzymes is increasing daily, it is imperative to develop a computational tool to classify the newly identified BL enzymes into one of its classes. There are two types of classification of BL enzymes: Molecular Classification and Functional Classification. Existing computational methods only address Molecular Classification and the performance of these existing methods is unsatisfactory. We addressed the unsatisfactory performance of the existing methods by implementing a Deep Learning approach called Convolutional Neural Network (CNN). We developed CNN-BLPred, an approach for the classification of BL proteins. The CNN-BLPred uses Gradient Boosted Feature Selection (GBFS) in order to select the ideal feature set for each BL classification. Based on the rigorous benchmarking of CCN-BLPred using both leave-one-out cross-validation and independent test sets, CCN-BLPred performed better than the other existing algorithms. Compared with other architectures of CNN, Recurrent Neural Network, and Random Forest, the simple CNN architecture with only one convolutional layer performs the best. After feature extraction, we were able to remove ~95% of the 10,912 features using Gradient Boosted Trees. During 10-fold cross validation, we increased the accuracy of the classic BL predictions by 7%. We also increased the accuracy of Class A, Class B, Class C, and Class D performance by an average of 25.64%. The independent test results followed a similar trend. We implemented a deep learning algorithm known as Convolutional Neural Network (CNN) to develop a classifier for BL classification. Combined with feature selection on an exhaustive feature set and using balancing method such as Random Oversampling (ROS), Random Undersampling (RUS) and Synthetic Minority Oversampling Technique (SMOTE), CNN-BLPred performs

Clinical Chemistry Reference Intervals for C57BL/6J, C57BL/6N, and C3HeB/FeJ Mice (Mus musculus).

Science.gov (United States)

Otto, Gordon P; Rathkolb, Birgit; Oestereicher, Manuela A; Lengger, Christoph J; Moerth, Corinna; Micklich, Kateryna; Fuchs, Helmut; Gailus-Durner, Valérie; Wolf, Eckhard; Hrabě de Angelis, Martin

2016-01-01

Although various mouse inbred strains are widely used to investigate disease mechanisms and to establish new therapeutic strategies, sex-specific reference intervals for laboratory diagnostic analytes that are generated from large numbers of animals have been unavailable. In this retrospective study, we screened data from more than 12,000 mice phenotyped in the German Mouse Clinic from January 2006 through June 2014 and selected animals with the genetic background of C57BL/6J, C57BL/6N, or C3HeB/FeJ. In addition, we distinguished between the C57BL/6NTac substrain and C57BL/6N mice received from other vendors. The corresponding data sets of electrolytes (sodium, potassium, calcium, chloride, inorganic phosphate), lipids (cholesterol, triglyceride), and enzyme activities (ALT, AST, ALP, α-amylase) and urea, albumin, and total protein levels were analyzed. Significant effects of age and sex on these analytes were identified, and strain- or substrain- and sex-specific reference intervals for 90- to 135-d-old mice were calculated. In addition, we include an overview of the literature that reports clinical chemistry values for wild-type mice of different strains. Our results support researchers interpreting clinical chemistry values from various mouse mutants and corresponding wild-type controls based on the examined strains and substrains.

X-ray studies of BL Lacertae objects

International Nuclear Information System (INIS)

Madejski, G.M.

1986-01-01

This thesis presents spectral x-ray data for BL Lac objects observed by the IPC and MPC aboard the Einstein Observatory and interprets that data in a context of their overall radiation spectra using synchrotron and synchrotron self-Compton models. The objects considered are: OJ 287, PKS 0735 + 178, I Zw 186, PKS 0548-322, Mkn 180, BL Lacertae, PKS 2155-304, H 0414-009 and H 0323 + 022. X-ray spectra of BL Lac objects are well described by a power law model with a low energy cutoff due to absorption within the own Galaxy. The best fit values of the energy spectral index α in the IPC (0.2-4.0 keV) band range from 0.73 to 2.35, with a mean of 1.2 and rms spread of 0.51. No single, universal index can fit the spectra of all objects. For all objects except PKS 0735 + 178, the x-ray spectrum is an extrapolation of the infrared/optical UV spectrum; in PKS 0735 + 178, the x-ray spectrum lies significantly below such an extrapolation. The overall electromagnetic distribution in those objects is interpreted as arising due to the synchrotron process in at least two spatial regions, with sizes respectively ∼10 18 cm for the radio component and ∼10 16 cm for the optical component. In objects where the x-ray spectrum lies on the extrapolation of the infrared-optical-ultraviolet spectrum, the x-ray emission is interpreted also to be due to the synchrotron process

Method for Pedestrian Crossing Risk Assessment and Safety Level Determination: the Case Study of Tallinn

Energy Technology Data Exchange (ETDEWEB)

Pashkevich, M.; Krasilnikova, A.; Antov, D.

2016-07-01

Pedestrians are a part of vulnerable road users which safety requires a special attention. Official statistics in Estonia from the last decade returns the following numbers: around 30 % of all road traffic accidents in the country were accidents with pedestrians, 32 % of all traffic fatalities were finished with pedestrian death. Pedestrian crossing has the biggest risk level between all kinds of pedestrian facilities, because it includes a direct conflict point between vehicle and pedestrian traffics. The article presents a method to assess risk of pedestrian crossing users and to determine safety level of this road infrastructure element. This approach is based on observation and collection of infrastructural as well as traffic data, which includes: (1) information about each pedestrian crossing facility, its location and state, (2) data about accidents with pedestrians and their features, (3) data from road traffic measurements. The main advantages of the described method are universality and comprehensiveness. The case study was done in Kristiine district of the city Tallinn, which was chosen as the most typical average district of Estonian capital. Results of this study are also presented in the article. (Author)

TRENDS IN URBAN STORM WATER QUALITY IN TALLINN AND INFLUENCES FROM STORMFLOW AND BASEFLOW

Directory of Open Access Journals (Sweden)

Bharat Maharjan

2016-04-01

Full Text Available Temporal trends provide a good interpretation of change in stormwater quality over time. This study aimed to analyse trends and influences due to stormflow and baseflow. Grab samples of 18-19 years from 1995 to 2014 recorded at outlets of 7 Tallinn watersheds were analysed for monotonic trend through seasonal Mann Kendall test for long-term, short-term, baseflow and stormflow. Statistically significant downward trends (P-value (p 0.05 and < 0.2 for 3 – SS, 1 – BOD, 1 – TN and 1 – TP were identified. Statistically significant long-term upward trends of pH were revealed in 5 basins, which reduced to 2 with 5 less significant upward trends over the 10 year period, indicating improvements in pH reduction. Härjapea has the highest pH without trend but it includes an upward trend of TN at p = 0.051. The highly possible causes for downward trends are street sweeping, sewer network improvement, decline in sub-urban agricultural areas, etc. The upward trend results of pH are related to increased alkalinisation due to acidic rain, weathering of carbonate rocks, sewage discharge and alkaline road dust. In most of the basins, stormflow has more influence on trends than baseflow.

BL.-SL. *balnā „brazdas; oda“

Directory of Open Access Journals (Sweden)

Vincas Urbutis

2011-12-01

Full Text Available BL.-SL. *balnā "SPLINT; HAUT"ZusammenfassungSl. *bolna „Splint (weiche saftige Holzschicht unter der Rinde; dünnes Häutchen, Haut“ (vgl. russ. болона́ „Splint“, čech. blána „dünnes Häutchen; Splint; (ačech. Haut, Fell“ hatte früher seine genaue formelle und semantische Entsprechung lit. *balna, von dem das Verb balnóti „schlagen, prügeln“ gebildet ist, dessen frühere Bedeutung „schälen, abhäuten“ war, vgl. nubalnóti „abscheuern, abhäuten, Haut abreißen“. Das läßt annehmen bl.—sl. *balnā „Splint; Haut“ — eine substantivierte feminine Form von dem Adjektiv, dessen Fortsetzung lit. bálnas (bal̃nas,-à „weiß, mit dem weißen Rücken (von einem Ochsen oder einer Kuh“ ist.

Optical polarization of high-energy BL Lacertae objects

Science.gov (United States)

Hovatta, T.; Lindfors, E.; Blinov, D.; Pavlidou, V.; Nilsson, K.; Kiehlmann, S.; Angelakis, E.; Fallah Ramazani, V.; Liodakis, I.; Myserlis, I.; Panopoulou, G. V.; Pursimo, T.

2016-12-01

Context. We investigate the optical polarization properties of high-energy BL Lac objects using data from the RoboPol blazar monitoring program and the Nordic Optical Telescope. Aims: We wish to understand if there are differences between the BL Lac objects that have been detected with the current-generation TeV instruments and those objects that have not yet been detected. Methods: We used a maximum-likelihood method to investigate the optical polarization fraction and its variability in these sources. In order to study the polarization position angle variability, we calculated the time derivative of the electric vector position angle (EVPA) change. We also studied the spread in the Stokes Q/I-U/I plane and rotations in the polarization plane. Results: The mean polarization fraction of the TeV-detected BL Lacs is 5%, while the non-TeV sources show a higher mean polarization fraction of 7%. This difference in polarization fraction disappears when the dilution by the unpolarized light of the host galaxy is accounted for. The TeV sources show somewhat lower fractional polarization variability amplitudes than the non-TeV sources. Also the fraction of sources with a smaller spread in the Q/I-U/I plane and a clumped distribution of points away from the origin, possibly indicating a preferred polarization angle, is larger in the TeV than in the non-TeV sources. These differences between TeV and non-TeV samples seem to arise from differences between intermediate and high spectral peaking sources instead of the TeV detection. When the EVPA variations are studied, the rate of EVPA change is similar in both samples. We detect significant EVPA rotations in both TeV and non-TeV sources, showing that rotations can occur in high spectral peaking BL Lac objects when the monitoring cadence is dense enough. Our simulations show that we cannot exclude a random walk origin for these rotations. Conclusions: These results indicate that there are no intrinsic differences in the

Theatrum Mundi: Ur-Hamlet

DEFF Research Database (Denmark)

Christoffersen, Erik Exe

2009-01-01

Om Odin Teatrets dramaturgier og om Barbas dramaturgi-begreb relateret til forestillingen Ur-Hamlet (2006)......Om Odin Teatrets dramaturgier og om Barbas dramaturgi-begreb relateret til forestillingen Ur-Hamlet (2006)...

Verdensteatrets forhandling af fremmedhed

DEFF Research Database (Denmark)

Christoffersen, Erik Exe

2009-01-01

Om Odin Teatret forestilling Ur-Hamlet, Kronborg, 200. Iscenesættelse, dramaturgi og global kontekst......Om Odin Teatret forestilling Ur-Hamlet, Kronborg, 200. Iscenesættelse, dramaturgi og global kontekst...

VizieR Online Data Catalog: The CLASS BL Lac sample (Marcha+, 2013)

Science.gov (United States)

Marcha, M. J. M.; Caccianiga, A.

2014-04-01

This paper presents a new sample of BL Lac objects selected from a deep (30mJy) radio survey of flat spectrum radio sources (the CLASS blazar survey). The sample is one of the largest well-defined samples in the low-power regime with a total of 130 sources of which 55 satisfy the 'classical' optical BL Lac selection criteria, and the rest have indistinguishable radio properties. The primary goal of this study is to establish the radio luminosity function (RLF) on firm statistical ground at low radio luminosities where previous samples have not been able to investigate. The gain of taking a peek at lower powers is the possibility to search for the flattening of the luminosity function which is a feature predicted by the beaming model but which has remained elusive to observational confirmation. In this study, we extend for the first time the BL Lac RLF down to very low radio powers ~1022W/Hz, i.e. two orders of magnitude below the RLF currently available in the literature. In the process, we confirm the importance of adopting a broader, and more physically meaningful set of classification criteria to avoid the systematic missing of low-luminosity BL Lacs. Thanks to the good statistics we confirm the existence of weak but significant positive cosmological evolution for the BL Lac population, and we detect, for the first time the flattening of the RLF at L~1025W/Hz in agreement with the predictions of the beaming model. (1 data file).

NLO+NLL collider bounds, Dirac fermion and scalar dark matter in the B-L model

Energy Technology Data Exchange (ETDEWEB)

Klasen, Michael [Westfaelische Wilhelms-Universitaet Muenster, Institut fuer Theoretische Physik, Muenster (Germany); Lyonnet, Florian [Southern Methodist University, Dallas, TX (United States); Queiroz, Farinaldo S. [Max-Planck-Institut fuer Kernphysik, Particle and Astroparticle Physics Division, Heidelberg (Germany)

2017-05-15

Baryon and lepton numbers being accidental global symmetries of the Standard Model (SM), it is natural to promote them to local symmetries. However, to preserve anomaly-freedom, only combinations of B-L are viable. In this spirit, we investigate possible dark matter realizations in the context of the U(1){sub B-L} model: (i) Dirac fermion with unbroken B-L; (ii) Dirac fermion with broken B-L; (iii) scalar dark matter; (iv) two-component dark matter. We compute the relic abundance, direct and indirect detection observables and confront them with recent results from Planck, LUX-2016, and Fermi-LAT and prospects from XENON1T. In addition to the well-known LEP bound M{sub Z}{sup {sub '}}/g{sub BL} >or similar 7 TeV, we include often ignored LHC bounds using 13 TeV dilepton (dimuon + dielectron) data at next-to-leading order plus next-to-leading logarithmic accuracy. We show that, for gauge couplings smaller than 0.4, the LHC gives rise to the strongest collider limit. In particular, we find M{sub Z}{sup {sub '}}/g{sub BL} > 8.7 TeV for g{sub BL} = 0.3. We conclude that the NLO+NLL corrections improve the dilepton bounds on the Z{sup '} mass and that both dark matter candidates are only viable in the Z{sup '} resonance region, with the parameter space for scalar dark matter being fully probed by XENON1T. Lastly, we show that one can successfully have a minimal two-component dark matter model. (orig.)

NEW HIGH- z FERMI BL LACS WITH THE PHOTOMETRIC DROPOUT TECHNIQUE

Energy Technology Data Exchange (ETDEWEB)

Kaur, A.; Ajello, M.; Hartmann, D. H.; Paliya, V. S. [Department of Physics and Astronomy, Clemson University, SC 29634-0978 (United States); Rau, A.; Greiner, J.; Bolmer, J.; Schady, P. [Max-Planck-Institut für extraterrestrische Physik, Giessenbachstraße 1, D-85748 Garching (Germany); Domínguez, A., E-mail: akaur@g.clemson.edu [Grupo de Altas Energías, Universidad Complutense, E-28040 Madrid (Spain)

2017-01-01

Determining redshifts for BL Lacertae (BL Lac) objects using the traditional spectroscopic method is challenging due to the absence of strong emission lines in their optical spectra. We employ the photometric dropout technique to determine redshifts for this class of blazars using the combined 13 broadband filters from Swift -UVOT and the multi-channel imager GROND at the MPG 2.2 m telescope at ESO's La Silla Observatory. The wavelength range covered by these 13 filters extends from far-ultraviolet to the near-infrared. We report results on 40 new Fermi- detected BL Lacs with the photometric redshift determinations for five sources, with 3FGL J1918.2–4110 being the most distant in our sample at z  = 2.16. Reliable upper limits are provided for 20 sources in this sample. Using the highest energy photons for these Fermi -LAT sources, we evaluate the consistency with the gamma-ray horizon due to the extragalactic background light.

Three new BL Lacertae objects in the Palomar-Green survey

Science.gov (United States)

Fleming, Thomas A.; Green, Richard F.; Jannuzi, Buell T.; Liebert, James; Smith, Paul S.; Fink, Henner

1993-01-01

We have identified three BL Lacertae objects in the Palomar-Green Survey which were previously misclassified as DC white dwarfs, namely PG 1246+586, PG 1424+240, and PG 1437+398. Our reclassification is based on the detection of these objects as x-ray sources in the ROSAT all-sky survey and upon our subsequent detection of intrinsic linearly polarized and variable optical emission from these sources. As a result of the ROSAT survey, the number of identified BL Lac objects in the Palomar-Green catalog of UV excess objects has been doubled. Corrected optical positions are presented for PG 1246+586 and PG 1437+398.

Ethanol inhibits B16-BL6 melanoma metastasis and cell phenotypes associated with metastasis.

Science.gov (United States)

Kushiro, Kyoko; Núñez, Nomelí P

2012-01-01

Every year, approximately 68,000 new cases of malignant melanoma are diagnosed in the US. Ethanol consumption inhibits metastasis of melanoma in mice, but the mechanism is not well understood. C57BL/6J ob/+ mice, given either water or 20% ethanol, were injected intravenously with B16-BL6 melanoma cells to determine pulmonary metastasis. The effects of ethanol on cell phenotypes and markers of the epithelial-to-mesenchymal transition were determined in cell culture. In mice, ethanol consumption inhibited experimental pulmonary metastasis. This inhibition was associated with decreased body weight, and levels of systemic leptin, and insulin. In cell culture, ethanol inhibited B16-BL6 cell motility, invasion, and anchorage-independent growth. Additionally, ethanol reduced Snai1 expression and increased E-cadherin expression. Lastly, ethanol increased the expression of Kiss1 metastasis-suppressor and the metastasis suppressor Nm23/nucleoside diphosphate kinase. In both animal and in cell culture conditions, ethanol inhibited the metastatic ability of B16-BL6 melanoma cells.

Abnormally banded chromosomal regions in doxorubicin-resistant B16-BL6 murine melanoma cells.

Science.gov (United States)

Slovak, M L; Hoeltge, G A; Ganapathi, R

1986-08-01

B16-BL6 murine melanoma cells were selected for cytogenetic evaluation during the stepwise development of increasing resistance in vitro to the antitumor antibiotic, doxorubicin (DOX). Karyotypic studies demonstrated extensive heteroploidy with both numerical and structural abnormalities which were not present in the parental DOX-sensitive B16-BL6 cells. Trypsin-Giemsa banding revealed the presence of several marker chromosomes containing abnormally banding regions (ABRs) in the 44-fold B16-BL6 DOX-resistant subline. These ABRs appeared to be more homogeneously staining at the higher DOX concentrations. Length measurements (ABR index) in seven banded metaphases indicated a direct correlation with increasing DOX concentration. When the DOX-resistant cells were grown in drug-free medium for 1 yr, the drug-resistant phenotype gradually declined in parallel with the level of resistance and the ABR index. DOX-induced cytogenetic damage examined by sister chromatid exchange methodology in parental B16-BL6 cells indicated a linear sister chromatid exchange:DOX dose-response relationship. However, after continuous treatment of parental B16-BL6 cells with DOX (0.01 microgram/ml) for 30 days, sister chromatid exchange scores were found to return to base-line values. The B16-BL6 resistant cells demonstrated a cross-resistant phenotype with N-trifluoroacetyladriamycin-14-valerate, actinomycin D, and the Vinca alkaloids but not with 1-beta-D-arabinofuranosylcytosine. The results suggest that ABR-containing chromosomes in DOX-resistant sublines may represent cytogenetic alterations of specific amplified genes involved in the expression of DOX resistance. Further studies are required to identify and define the possible gene products and to correlate their relationship to the cytotoxic action of doxorubicin.

BL Lacertae: X-ray spectral evolution and a black-hole mass estimate

Science.gov (United States)

Titarchuk, Lev; Seifina, Elena

2017-06-01

We present an analysis of the spectral properties observed in X-rays from active galactic nucleus BL Lacertae using RXTE, Suzaku, ASCA, BeppoSAX, and Swift observations. The total time covered by these observations is approximately 20 yr. We show strong observational evidence that this source undergoes X-ray spectral transitions from the low hard state (LHS) through the intermediate state (IS) to the high soft state (HSS) during these observations. During the RXTE observations (1997-2001, 180 ks, for a total 145 datasets), the source was approximately 75%, 20% and only 5% of the time in the IS, LHS, and HSS, respectively. We also used Swift observations (470 datasets, for a total 800 ks), which occurred during 12 yr (2005-2016), the broadband (0.3-200 keV) data of BeppoSAX (1997-2000, 160 ks), and the low X-ray energy (0.3-10 keV) data of ASCA (1995-1999, 160 ks). Two observations of Suzaku (2006, 2013; 50 ks) in combinations with long-term RXTE and Swift data-sets fortunately allow us to describe all spectral states of BL Lac. The spectra of BL Lac are well fitted by the so-called bulk motion Comptonization (BMC) model for all spectral states. We have established the photon index saturation level, Γsat = 2.2 ± 0.1, in the Γ versus mass accretion rate (Ṁ) correlation. This Γ - Ṁ correlation allows us to estimate the black-hole (BH) mass in BL Lac to be MBH 3 × 107M⊙ for a distance of 300 Mpc. For the BH mass estimate, we use the scaling method taking stellar-mass Galactic BHs 4U 1543-47 and GX 339-4 as reference sources. The Γ - Ṁ correlation revealed in BL Lac is similar to those in a number of stellar-mass Galactic BHs and two recently studied intermediate-mass extragalactic BHs. It clearly shows the correlation along with the very extended Γ saturation at 2.2. This is robust observational evidence for the presence of a BH in BL Lac. We also reveal that the seed (disk) photon temperatures are relatively low, of order of 100 eV, which are consistent

Spectroscopy of optically selected BL Lac objects and their γ-ray emission

Energy Technology Data Exchange (ETDEWEB)

Sandrinelli, A.; Treves, A.; Farina, E. P.; Landoni, M. [Università degli Studi dell' Insubria, Via Valleggio 11, I-22100 Como (Italy); Falomo, R. [INAF-Osservatorio Astronomico di Padova, Vicolo dell Osservatorio 5, I-35122 Padova (Italy); Foschini, L.; Sbarufatti, B., E-mail: angela.sandrinelli@brera.inaf.it [INAF-Osservatorio Astronomico di Brera, Via Emilio Bianchi 46, I-23807 Merate (Italy)

2013-12-01

We present Very Large Telescope optical spectroscopy of nine BL Lac objects of unknown redshift belonging to the list of optically selected radio-loud BL Lac candidates. We explore their spectroscopic properties and possible link with gamma-ray emission. From the new observations we determine the redshifts of four objects from faint emission lines or from absorption features of their host galaxies. In three cases we find narrow intervening absorptions from which a lower limit to the redshift is inferred. For the remaining two featureless sources, lower limits to the redshift are deduced from the absence of spectral lines. A search for γ counterpart emission shows that six out of the nine candidates are Fermi γ-ray emitters and we find two new detections. Our analysis suggests that most of the BL Lac objects still lacking redshift information are most likely located at high redshifts.

Induced immune response of Escherichia coli BL21 expressing recombinant MSP1a and MSP1b proteins of Anaplasma marginale

Directory of Open Access Journals (Sweden)

Katia Tamekuni

2009-11-01

Full Text Available This work aims to evaluate the potential of immunization with E. coli BL21 expressing the recombinant rMSP1a and rMSP1b proteins of Anaplasma marginale. E. coli BL21 was transformed with recombinant plasmids pET102/msp1α and pET101/msp1β, and rMSP1a and rMSP1b were expressed after induction by IPTG. BALB/c mice were vaccinated with formolized BL21/rMSP1a and BL21/rMSP1b, and the production in mice sera of whole IgG was determined by ELISA. The mice immunized with BL21/rMSP1a showed a better humoral response for whole IgG when compared to the mice immunized with BL21/rMSP1b; these mice exhibited a small response after the second vaccination. Sera of mice immunized with BL21/rMSP1a reacted via western blot with BL21 and rMSP1a, with molecular masses varying from 70 to 105 kDa. Sera of mice immunized with BL21/rMSP1b reacted with BL21 and rMSP1b with a molecular mass of 100 kDa. These results demonstrate that BL21 containing rMSP1a and rMSP1b in the outer membrane were able to produce an immune response in mice, reinforcing its use in vaccine models against bovine anaplasmosis.Esse trabalho avaliou o potencial de imunização de Escherichia coli BL21 expressando as proteínas recombinantes rMSP1a e rMSP1b de Anaplasma marginale. A E. coli BL21 foi transformada com os plasmídios recombinantes pET102/msp1α e pET101/msp1β e as proteínas rMSP1a e rMSP1b foram expressas após indução com IPTG. Camundongos BALB/c foram vacinados com BL21/rMSP1a e BL21/rMSP1b formolisadas, e a produção de IgG total foi determinada pelo teste de ELISA nos soros dos camundongos imunizados. Os camundongos imunizados com a BL21/rMSP1a mostraram uma melhor resposta humoral para IgG total, comparada à resposta apresentada pelos camundongos imunizados com BL21/rMSP1b; estes camundongos exibiram uma menor resposta após a segunda vacinação. Soros de camundongos imunizados BL21/rMSP1a reagiram pelo western blot com BL21 e rMSP1a, com massa molecular variando de 70 a

Regulation of methane oxidation in the facultative methanotroph Methylocella silvestris BL2.

Science.gov (United States)

Theisen, Andreas R; Ali, M Hanif; Radajewski, Stefan; Dumont, Marc G; Dunfield, Peter F; McDonald, Ian R; Dedysh, Svetlana N; Miguez, Carlos B; Murrell, J Colin

2005-11-01

The molecular regulation of methane oxidation in the first fully authenticated facultative methanotroph Methylocella silvestris BL2 was assessed during growth on methane and acetate. Problems of poor growth of Methylocella spp. in small-scale batch culture were overcome by growth in fermentor culture. The genes encoding soluble methane monooxygenase were cloned and sequenced, which revealed that the structural genes for soluble methane monooxygenase, mmoXYBZDC, were adjacent to two genes, mmoR and mmoG, encoding a sigma54 transcriptional activator and a putative GroEL-like chaperone, located downstream (3') of mmoC. Transcriptional analysis revealed that the genes were all cotranscribed from a sigma54-dependent promoter located upstream (5') of mmo X. The transcriptional start site was mapped. Transcriptional analysis of soluble methane monooxygenase genes and expression studies on fermentor grown cultures showed that acetate repressed transcription of sMMO in M. silvestris BL2. The possibility of the presence of a particulate, membrane-bound methane monooxygenase enzyme in M. silvestris BL2 and the copper-mediated regulation of soluble methane monooxygenase was investigated. Both were shown to be absent. A promoter probe vector was constructed and used to assay transcription of the promoter of the soluble methane monoxygenase genes of M. silvestris BL2 grown under various conditions and with different substrates. These data represent the first insights into the molecular physiology of a facultative methanotroph.

The gBL transport equations

International Nuclear Information System (INIS)

Mynick, H.E.

1989-05-01

The transport equations arising from the ''generalized Balescu- Lenard'' (gBL) collision operator are obtained, and some of their properties examined. The equations contain neoclassical and turbulent transport as two special cases, having the same structure. The resultant theory offers potential explanation for a number of results not well understood, including the anomalous pinch, observed ratios of Q/ΓT on TFTR, and numerical reproduction of ASDEX profiles by a model for turbulent transport invoked without derivation, but by analogy to neoclassical theory. The general equations are specialized to consideration of a number of particular transport mechanisms of interest. 10 refs

Phenotypic stability of B16-BL6 melanoma exposed to low levels of tyrosine and phenylalanine.

Science.gov (United States)

Elstad, C A; Meadows, G G

1990-01-01

We previously demonstrated that tyrosine (Tyr) and phenylalanine (Phe) restriction suppresses metastatic heterogeneity of B16-BL6 (BL6) melanoma and selects for tumor variants with decreased metastatic potential. In this study, we investigate stability of this Tyr- and Phe-modulated tumor phenotype by sequentially transplanting BL6 in vivo into mice fed Low Tyr and Phe Diet. Metastatic potential of BL6 is suppressed after one subcutaneous passage. Suppression is unlikely to result from inhibition of tumor growth, since growth in vitro is significantly increased. The metastatic potential of the Tyr- and Phe-modulated tumor is unstable after in vivo passage, and lung colonizing ability is regenerated after ten in vivo passages. Conversely, the antimetastatic effect of Tyr and Phe restriction is stable after prolonged in vitro passage. The metastatic potential of tumors from mice fed Normal Diet is unstable after long-term in vitro culture. Sensitivity to adriamycin of BL6 from mice fed Low Tyr and Phe Diet is increased and is not altered by change in metastatic potential.

Observations of low and intermediate-frequency-peaked BL Lacs above 100 GeV with VERITAS

Directory of Open Access Journals (Sweden)

Errando M.

2013-12-01

Full Text Available Most of the ~ 50 blazars detected to date at TeV energies (E > 0.1 TeV are high-frequency-peaked BL Lacs (HBLs. Only a handful episodic detections of low- and intermediate-frequency-peaked BL Lacs (LBL/IBLs, with synchrotron peak frequencies in the infrared and optical regime have been reported by ground-based gamma-ray telescopes, typically during high-flux states. The VERITAS array located in southern Arizona has observed five known TeV LBL/IBLs since 2009: 3C 66A, WComae, PKS 1424+240, S5 0716+714 and BL Lacertae, with exposures of 5-10 hours/year, which so far resulted in the detection of a bright, sub-hour timescale gamma-ray flare of BL Lacertae in June 2011. We also report the detection and characterization of two new IBLs: VER J0521+211 and B2 1215+30.

Short outlines of books by Estonian authors / Janika Kronberg, Rutt Hinrikus

Index Scriptorium Estoniae

Kronberg, Janika, 1963-

2006-01-01

Arvustus: Krull, Hasso. Loomise mõnu ja kiri. Tallinn : Kultuurileht, 2006 ; Aleksejev, Tiit. Valge kuningriik. Tallinn : Varrak, 2006 ; Baturin, Nikolai. Sõnajalg kivis. Tallinn : Eesti Raamat, 2006 ; Nõu, Helga. Ood lastud rebasele. Tallinn : Eesti Keele Sihtasutus, 2006 ; Kaus, Jan. Tema. Tallinn : Tuum, 2006 ; Krull, Hasso. Talv. Tallinn : Tuum, 2006 ; Soomets, Triin. Väljas. Tallinn : Tuum, 2006 ; Kareva, Doris. Aja kuju. Tallinn : Verb, 2006 ; Vint, Toomas. Topeltvalguses. Tallinn : Eesti Keele Sihtasutus, 2005 ; Bristol, Piret. Sõud. Tallinn : Eesti Keele Sihtasutus, 2005 ; Valton, Arvo. Taltsutatud lammas : jutud. Tallinn : Kirjastuskeskus, 2005 ; Kivastik, Mart. Külmetava kunstniku portreed. Viinistu triloogia. Tartu : Väike Öömuusika, 2006

Quantitative SRXRF analysis on the BL15U1 beamline at SSRF

International Nuclear Information System (INIS)

Zhang Yanle; Yu Xiaohan

2010-01-01

In this paper, we give an introduction first to two quantification methods for synchrotron radiation X-ray fluorescence analysis (SRXRF), namely fundamental parameters method and Monte-Carlo simulation method, for their application on the BL15U1 beamline (hard X-ray microprobe) at SSRF (Shanghai Synchrotron Radiation Facility). Effectiveness of the two methods is demonstrated and the XRF detection limits of the BL15U1 beamline are calculated. The results show that, quantitative analysis at the ppm level can be done using the two methods, with an accuracy of better than 10%. Although both the methods are valid for the SRXRF data analysis,the Monte Carlo method gives better analysis result, as it compares the simulated spectrum with the experiment spectrum, and this helps the determination of experiment parameters and thus minimizes the error caused by incorrect parameters. Finally, the detection limits shows that the BL15U1 beamline is capable of carrying out standard-of-the-art XRF experiment. (authors)

Short outlines of books by Estonian authors / Janika Kronberg, Rutt Hinrikus

Index Scriptorium Estoniae

Kronberg, Janika, 1963-

2004-01-01

Tutvustus: Talvik, Heiti. Legendaarne. Tartu : Ilmamaa, 2004 ; Pilter, Lauri. Lohejas pilv : romaan lühijuttudes. Tallinn : Tuum, 2004 ; Raud, Rein. Hector ja Bernard. Tallinn : Tuum, 2004 ; Ruben, Aarne. Elajas trepi eelastmel. Tallinn : Tuum, 2004 ; fs. 2004. Tallinn : Tuum, 2004 ; Normet, Dagmar. ...ainult võti taskus. Tallinn : Varrak, 2004 ; Künnap, Asko. Ja sisalikud vastasid (kolmes kirjas). Tallinn : Näo Kirik, 2003 ; Kall, Toomas. Armas aeg. Tallinn : Tänapäev, 2004 ; Õunapuu, Ervin. Eesti gootika II. Tallinn : Umara, 2004 ; Soomets, Triin. Leping number 2 : luuletusi 2000-2003. Tallinn : Tuum, 2004 ; Tuulik, Jüri. Linnusita : [jutustused, lühijutud, näidendid ja vested]. Tallinn : Maalehe Raamat, 2004 ; Raudam, Toomas. Teie. Tallinn : Eesti Keele Sihtasutus, 2003 ; Härm, Viiu. Keegi teeline : luuletused. Tallinn : Varrak, 2004 ; Härm, Viiu. Õhuaken : romaan. Tallinn : Varrak, 2004

Inhibition of B16-BL6 melanoma growth in mice by methionine-enkephalin.

Science.gov (United States)

Murgo, A J

1985-08-01

The antitumor effect of methionine-enkephalin [( Met]enkephalin) was demonstrated in C57BL/6J mice inoculated with B16-BL6 melanoma cells. Local subcutaneous tumor growth was inhibited with a 50-micrograms dose daily for 7 or 14 days. The antitumor effect of [Met]enkephalin was inhibited by the administration of the opioid receptor antagonist naloxone. Naloxone alone had no significant effect on tumor growth.

The BL Lac objects PKS 1144-379

International Nuclear Information System (INIS)

Nicolson, G.D.; Glass, I.S.; Feast, M.W.; Andrews, P.J.

1979-01-01

The highly variable radio source PKS 1144-379 has been monitored at 13 cm and 6 cm over a period of 3 years. It has been identified with an object whose photographic image is star-like. From infrared photometry, UBVRsub(KC)Isub(KC) photometry and spectroscopy, it is concluded that PKS 1144-379 is a BL Lac object with msub(v) approximately = 16.2. (author)

Identification of riboflavin: revealing different metabolic characteristics between Escherichia coli BL21(DE3) and MG1655.

Science.gov (United States)

Wang, Xinran; Wang, Qian; Qi, Qingsheng

2015-06-01

There are many physiological differences between Escherichia coli B and K-12 strains, owing to their different origins. Deeper insight into the metabolic and regulative mechanisms of these strains will inform improved usage of these industrial workhorses. In the present study, we observed that BL21 fermentation broth gradually turned yellow during cultivation. By spectral analysis and liquid chromatography-mass spectrometry identification, we confirmed for the first time that the yellow substance accumulated in the fermentation broth is riboflavin. Comparing the enzyme sequences involved in riboflavin metabolism between BL21 and MG1655, we identified a site mutation on the 115 residue of bifunctional riboflavin kinase/FMN adenylyltransferase (RibF) in BL21. This His115Leu mutation was found to reduce enzyme activity to 55% of that of MG1655, which is probably one reason for riboflavin accumulation in BL21. Quantitative PCR analysis showed that genes of the entire branch of the riboflavin and FAD biosynthesis pathways in BL21 were up-regulated. Several physiological and metabolic characteristics of BL21 and MG1655 were found to be different, and may also be related to the riboflavin accumulation. © FEMS 2015. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Short outlines of books by Estonian authors / Brita Melts, Rutt Hinrikus, Maret Vaher and Arno Oja

Index Scriptorium Estoniae

Melts, Brita

2014-01-01

Arvustus: Kronberg, Janika. Rännud kuue teejuhiga. Tallinn : Go Group, 2013 ; Kallaste, Helen. Kogutud hetked. Tallinn : Verb, 2012 ; Ahi, Eda. Gravitatsioon. Tallinn : Verb, 2013 ; Heinsaar, Mehis. Ülikond. Tallinn : Menu Kirjastus, 2013 ; Kann, Kaja. Eratee. Tallinn : Hea Lugu, 2013 ; Kivirähk, Andrus. Maailma otsas. Tallinn : Eesti Keele Sihtasutus, 2013 ; Kurvitz, Robert. Püha ja õudne lõhn. Tallinn : ZA/UM, 2013 ; Mattheus, Ülo. Tema salajane palve. Tallinn : Tuum, 2013 ; Kangro, Maarja. Dantelik auk. Tallinn : Eesti Keele Sihtasutus, 2012

Short outlines of books by Estonian authors / Brita Melts, Rutt Hinrikus and Janika Kronberg

Index Scriptorium Estoniae

Melts, Brita

2013-01-01

Arvustus: Baturin, Nikolai. Lendav hollandlanna. Tallinn : Eesti Raamat, 2012 ; Friedenthal, Meelis. Mesilased. Tallinn : Varrak, 2012 ; Kaus, Jan. Koju. Tallinn : Tuum, 2012 ; Kaldmaa, Kätlin. Armastuse tähestik. Tallinn : NyNorden, 2012 ; Kivastik, Mart. Vietnami retsept. Tartu : Väike Öömuusika, 2012 ; Õnnepalu, Tõnu. Kuidas on elada. Tallinn : Varrak, 2012 ; Õnnepalu, Tõnu. Mandala. Tallinn : Varrak, 2012 ; Riismaa, Kaur. Rebase matmine. Tallinn : Näo Kirik, 2012 ; Vadi, Urmas. Tagasi Eestisse. Saarde-Pärnu : Jumalikud Ilmutused, 2012 ; Vint, Toomas. Avalikult abielust. Tallinn : Tulikiri, 2012 ; Kangro, Maarja. Dantelik auk. Tallinn : Eesti Keele Sihtasutus, 2012 ; Kaevats, Mihkel. Ungari kirsid & teisi luuletusi. Tallinn : Pegasus, 2012.

Mitmekülgne eesti lastekirjandus [2006. a.] / Jaanika Palm

Index Scriptorium Estoniae

Palm, Jaanika, 1973-

2008-01-01

Arvustus: Tungal, Leelo. Lätikeelne jäätis ja teisi luuletusi. Tallinn : Tuum, 2006 ; Trull, Ilmar. Musta kassi mumba. Tallinn : Eesti Ekspressi Kirjastus, 2006 ; Wimberg. Põngerjate laulud. Tallinn : Varrak, 2006 ; Muidugi, Eino. Lõbus pere ütleb tere! Tallinn : Koolibri, 2006 ; Nemvalts, Urmas. Väikeste meeste jutud. [Tallinn] : Grenader, 2006 ; Kangro, Maarja, Kangro, Kirke. Puuviljadraakon. Tallinn : Koolibri, 2006 ; Kilkson, Tiina. Pisikese Peetri pikk pühapäev. Tallinn : Koolibri, 2006 ; Pelmas, Elsa. Sussipäkapikk Siisi seiklused. Tallinn : TEA Kirjastus, 2006 ; Sauter, Peeter. Laiskade laste raamat. Tallinn : Huma, 2006 ; Kivirähk, Andrus. Leiutajateküla Lotte. Tallinn : Eesti Joonisfilm, 2006 ; Ulman, Mihkel. Nukkude teater. Tartu : Elmatar, 2006 ; Rannap, Jaan. Roheline kindlus. Tallinn : Tiritamm, 2006 ; Vallik, Aidi. Narkohollo ehk Florose vabastamine. Haapsalu : Lugu-Loo, 2006 ; Leesalu, Diana. Mängult on päriselt. Tallinn : Tänapäev, 2006 ; Laidla, Siiri. Pärnaõietee. Tallinn : Canopus, 2006

Mitmekülgne eesti lastekirjandus [2006. a.] / Jaanika Palm

Index Scriptorium Estoniae

Palm, Jaanika, 1973-

2007-01-01

Arvustus: Tungal, Leelo. Lätikeelne jäätis ja teisi luuletusi. Tallinn : Tuum, 2006 ; Trull, Ilmar. Musta kassi mumba. Tallinn : Eesti Ekspressi Kirjastus, 2006 ; Wimberg. Põngerjate laulud. Tallinn : Varrak, 2006 ; Muidugi, Eino. Lõbus pere ütleb tere! Tallinn : Koolibri, 2006 ; Nemvalts, Urmas. Väikeste meeste jutud. [Tallinn] : Grenader, 2006 ; Kangro, Maarja, Kangro, Kirke. Puuviljadraakon. Tallinn : Koolibri, 2006 ; Kilkson, Tiina. Pisikese Peetri pikk pühapäev. Tallinn : Koolibri, 2006 ; Pelmas, Elsa. Sussipäkapikk Siisi seiklused. Tallinn : TEA Kirjastus, 2006 ; Sauter, Peeter. Laiskade laste raamat. Tallinn : Huma, 2006 ; Kivirähk, Andrus. Leiutajateküla Lotte. Tallinn : Eesti Joonisfilm, 2006 ; Ulman, Mihkel. Nukkude teater. Tartu : Elmatar, 2006 ; Rannap, Jaan. Roheline kindlus. Tallinn : Tiritamm, 2006 ; Vallik, Aidi. Narkohollo ehk Florose vabastamine. Haapsalu : Lugu-Loo, 2006 ; Leesalu, Diana. Mängult on päriselt. Tallinn : Tänapäev, 2006 ; Laidla, Siiri. Pärnaõietee. Tallinn : Canopus, 2006

Effects of electroacupuncture at BL33 on detrusor smooth muscle activity in a rat model of urinary retention.

Science.gov (United States)

Liu, Xiaoxu; Liu, Kun; Zhi, Mujun; Mo, Qian; Gao, Xinyan; Liu, Zhishun

2017-12-01

Detrusor smooth muscle (DSM) underactivity may lead to urinary retention (UR). Electroacupuncture (EA) at BL33 may be effective in improving DSM contractions. This study aimed to investigate: (1) the effect of EA at BL33; and (2) the effect of different manipulation methods at BL33 on the modulation of DSM contractions in UR rats. 30 male Sprague-Dawley rats were anaesthetised with urethane and modelled by urethral outlet obstruction. First, 2 Hz EA at BL33, SP6 and LI4 wasrandomly applied to the UR rats for 5 min to observe the immediate effects (n=10); second, manual acupuncture (MA) (n=10) and 100 Hz EA (n=10) were applied with the same programme. DSM electromyography (EMG) and cystometrogram data were evaluated. (1) 2 Hz EA at BL33 and SP6 significantly increased DSM discharging frequency (0.80±0.10 Hz, P0.05). Compared with SP6, EA at BL33 had greater positive effects on DSM discharging frequency, duration of discharging, and duration of voiding (all P<0.05). (2) No statistically significant differences were shown between MA, 2 Hz EA and 100 Hz EA interventions when stimulating at BL33, SP6 or LI4. EA at BL33 improved DSM contractions to a greater degree than EA at SP6 or LI4. There were no differences in effect when stimulating using 2 Hz EA, 100 Hz EA and MA. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Accretion disk emission from a BL Lacertae object

International Nuclear Information System (INIS)

Wandel, A.; Urry, C.M.

1991-01-01

It is suggested here that the UV and X-ray emission of BL Lac objects may originate in an accretion disk. Using detailed calculations of accretion disk spectra, the best-measured ultraviolet and soft X-ray spectra of the BL Lac object PKS 2155-304 are fitted, and the mass and accretion rate required is determined. The ultraviolet through soft X-ray continuum is well fitted by the spectrum of an accretion disk, but near-Eddington accretion rates are required to produce the soft X-ray excess. A hot disk or corona could Comptonize soft photons from the cool disk and produce the observed power-law spectrum in the 1-10 keV range. The dynamic time scale in the disk regions that contribute most of the observed ultraviolet and soft X-ray photons are consistent with the respective time scales for intensity variations observed in these two wave bands; the mass derived from fitting the continuum spectrum is consistent with the limit derived from the fastest hard X-ray variability. 37 refs

Bump masses for BL Her stars

International Nuclear Information System (INIS)

Davis, C.G.

1982-01-01

The masses of classical Cepheids can be determined by using the phase of the Hertzsprung bump on the light or velocity curve, Cox-Stewart opacities, and nonlinear pulsation theory. The fact that these bump masses are some 60% lower than the evolutionary masses raises some questions about this approach. In support of our method, we calculate the light curve for BL Her, a population II Cepheid, with an observed bump on the declining portion of its light curve. The nonlinear hydrodynamic model we use (Davis and Davison - 1978) resolves the light curve by dynamic zoning and allows us the opportunity to make a direct comparison of the calculated light curve to the observations, using a prescribed mass, luminosity and effective temperature. The parameters for BL Her are from a linear model (Hodson, Cox, and King - 1982) that has nearly the correct period (1./sup d/2) and the correct period ratio from resonance theory (π 2 /π 0 = 0.53) for a bump to appear on the declining portion of the light curve as observed. These parameters are: M = 0.55 M, L = 95.0 L, and T/sub eff/ = 6500 K. This mass is near the evolutionary mass as described by Schwartzschild and Haerm (1970). The model results agree well with the observations and the color-T/sub eff/ relation has the same slope as that observed for RR Lyrae stars by the Oke, Giver and Searle (1965) relationship

Site Characterization Data from the U3ax/bl Exploratory Boreholes at the Nevada Test Site

International Nuclear Information System (INIS)

2005-01-01

This report provides qualitative analyses and preliminary interpretations of hydrogeologic data obtained from two 45-degree, slanted exploratory boreholes drilled within the Area 3 Radioactive Waste Management Site (RWMS) at the Nevada Test Site. Borehole UE-3bl-D1 was drilled beneath the U3ax/bl mixed waste disposal unit, and Borehole UE-3bl-U1 was drilled in undisturbed alluvium adjacent to the disposal unit. The U3ax/bl disposal unit is located within two conjoined subsidence craters, U3ax and U3bl, which were created by underground nuclear testing. Data from these boreholes were collected to support site characterization activities for the U3ax/bl disposal unit and the entire Area 3 RWMS. Site characterization at disposal units within the Area 3 RWMS must address the possibility that subsidence craters and associated disturbed alluvium of the chimneys beneath the craters might serve as pathways for contaminant migration. The two boreholes were drilled and sampled to compare hydrogeologic properties of alluvium below the waste disposal unit with those of adjacent undisturbed alluvium. Whether Borehole UE-3bl-D1 actually penetrated the chimney of the U3bl crater is uncertain. Analyses of core samples showed little difference in hydrogeologic properties between the two boreholes. Important findings of this study include the following: No hazardous or radioactive constituents of waste disposal concern were found in the samples obtained from either borehole. No significant differences in physical and hydrogeologic properties between boreholes is evident, and no evidence of significant trends with depth for any of these properties was observed. The values observed are typical of sandy materials. The alluvium is dry, with volumetric water content ranging from 5.6 to 16.2 percent. Both boreholes exhibit a slight increase in water content with depth, the only such trend observed. Water potential measurements on core samples from both boreholes show a large positive

Site Characterization Data from the U3ax/bl Exploratory Boreholes at the Nevada Test Site

Energy Technology Data Exchange (ETDEWEB)

Bechtel Nevada; U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office

2005-08-01

This report provides qualitative analyses and preliminary interpretations of hydrogeologic data obtained from two 45-degree, slanted exploratory boreholes drilled within the Area 3 Radioactive Waste Management Site (RWMS) at the Nevada Test Site. Borehole UE-3bl-D1 was drilled beneath the U3ax/bl mixed waste disposal unit, and Borehole UE-3bl-U1 was drilled in undisturbed alluvium adjacent to the disposal unit. The U3ax/bl disposal unit is located within two conjoined subsidence craters, U3ax and U3bl, which were created by underground nuclear testing. Data from these boreholes were collected to support site characterization activities for the U3ax/bl disposal unit and the entire Area 3 RWMS. Site characterization at disposal units within the Area 3 RWMS must address the possibility that subsidence craters and associated disturbed alluvium of the chimneys beneath the craters might serve as pathways for contaminant migration. The two boreholes were drilled and sampled to compare hydrogeologic properties of alluvium below the waste disposal unit with those of adjacent undisturbed alluvium. Whether Borehole UE-3bl-D1 actually penetrated the chimney of the U3bl crater is uncertain. Analyses of core samples showed little difference in hydrogeologic properties between the two boreholes. Important findings of this study include the following: No hazardous or radioactive constituents of waste disposal concern were found in the samples obtained from either borehole. No significant differences in physical and hydrogeologic properties between boreholes is evident, and no evidence of significant trends with depth for any of these properties was observed. The values observed are typical of sandy materials. The alluvium is dry, with volumetric water content ranging from 5.6 to 16.2 percent. Both boreholes exhibit a slight increase in water content with depth, the only such trend observed. Water potential measurements on core samples from both boreholes show a large positive

Short outlines of books by Estonian authors / Janika Kronberg, Rutt Hinrikus

Index Scriptorium Estoniae

Kronberg, Janika, 1963-

2008-01-01

Arvustus: Kareva, Doris. Lõige. Tallinn : Verb, 2007 ; Õnnepalu, Tõnu. Flandria päevik. Tallinn : Varrak, 2007 ; Mihkelson, Ene. Katkuhaud. Tallinn : Varrak, 2007 ; Vint, Toomas. Mäluauguga naine. Tallinn : Eesti Keele Sihtasutus, 2007 ; Pervik, Aino. Suleline, Puhuja ja must munk. Tallinn : Tänapäev, 2007 ; Mutt, Mihkel. Siseemigrant. Novellid Rui taevalike kommentaaridega. Tallinn : Fabian, 2007 ; Nõlvak, Valentine. Ellujääja mälestused. Tallinn : Varrak, 2007 ; Tungal, Leelo. Täisminevik. Tallinn : Tänapäev, 2007 ; Kangro, Maarja. Tule mu koopasse, mateeria. Tallinn : Eesti Keele Sihtasutus, 2007

Short Outlines of Books by Estonian Authors / Janika Kronberg, Rutt Hinrikus

Index Scriptorium Estoniae

Kronberg, Janika, 1963-

2009-01-01

Arvustus: Karusoo, Merle. Kui ruumid on täis : Eesti rahva elulood teatritekstides 1982-2005. Tallinn : Varrak, 2008 ; Aleksejev, Tiit. Palveränd. Tallinn : Varrak, 2008 ; Saat, Mari. Lasnamäe lunastaja. Tallinn : Tuum, 2008 ; Tarand, Mari. Ajapildi sees. Tartu : Ilmamaa, 2008 ; Ojamaa, Liisi. Jõgi asfaldi all. Tallinn : Varrak, 2008 ; Kaalep, Ain. Muusad ja maastikud. Luuletused aastaist 1945-2008. Tallinn : Tänapäev, 2008 ; Toona, Elin. Ella. Tallinn : Kultuurileht, 2008 ; Hellerma, Kärt. Sinine missa. Valik reisikirju. Tallinn : Tuum, 2008 ; Raud, Rein. Vend. Tallinn : Tuum, 2008 ; Kruusa, Kalju. Pilvedgi mindgi liigutavadgi. Tallinn : Koma, 2008

Comparison of male chimeric mice generated from microinjection of JM8.N4 embryonic stem cells into C57BL/6J and C57BL/6NTac blastocysts.

Science.gov (United States)

Fielder, Thomas J; Yi, Charles S; Masumi, Juliet; Waymire, Katrina G; Chen, Hsiao-Wen; Wang, Shuling; Shi, Kai-Xuan; Wallace, Douglas C; MacGregor, Grant R

2012-12-01

To identify ways to improve the efficiency of generating chimeric mice via microinjection of blastocysts with ES cells, we compared production and performance of ES-cell derived chimeric mice using blastocysts from two closely related and commonly used sub-strains of C57BL/6. Chimeras were produced by injection of the same JM8.N4 (C57BL/6NTac) derived ES cell line into blastocysts of mixed sex from either C57BL/6J (B6J) or C57BL/6NTac (B6NTac) mice. Similar efficiency of production and sex-conversion of chimeric animals was observed with each strain of blastocyst. However, B6J chimeric males had fewer developmental abnormalities involving urogenital and reproductive tissues (1/12, 8%) compared with B6NTac chimeric males (7/9, 78%). The low sample size did not permit determination of statistical significance for many parameters. However, in each category analyzed the B6J-derived chimeric males performed as well, or better, than their B6NTac counterparts. Twelve of 14 (86%) B6J male chimeras were fertile compared with 6 of 11 (55%) B6NTac male chimeras. Ten of 12 (83%) B6J chimeric males sired more than 1 litter compared with only 3 of 6 (50%) B6NTac chimeras. B6J male chimeras produced more litters per productive mating (3.42 ± 1.73, n = 12) compared to B6NTac chimeras (2.17 ± 1.33, n = 6). Finally, a greater ratio of germline transmitting chimeric males was obtained using B6J blastocysts (9/14; 64%) compared with chimeras produced using B6NTac blastocysts (4/11; 36%). Use of B6J host blastocysts for microinjection of ES cells may offer improvements over blastocysts from B6NTac and possibly other sub-strains of C57BL/6 mice.

Therapeutic efficacy of interleukin-2 activated killer cells against adriamycin resistant mouse B16-BL6 melanoma.

Science.gov (United States)

Gautam, S C; Chikkala, N F; Lewis, I; Grabowski, D R; Finke, J H; Ganapathi, R

1992-01-01

Development of multidrug-resistance (MDR) remains a major cause of failure in the treatment of cancer with chemotherapeutic agents. In our efforts to explore alternative treatment regimens for multidrug-resistant tumors we have examined the sensitivity of MDR tumor cell lines to lymphokine activated killer (LAK) cells. Adriamycin (ADM) resistant B16-BL6 melanoma, L1210 and P388 leukemic cell lines were tested for sensitivity to lysis by LAK cells in vitro. While ADM-resistant B16-BL6 and L1210 sublines were found to exhibit at least 2-fold greater susceptibility to lysis by LAK cells, sensitivity of ADM-resistant P388 cell was similar to that of parental cells. Since ADM-resistant B16-BL6 cells were efficiently lysed by LAK cells in vitro, the efficacy of therapy with LAK cells against the ADM-resistant B16-BL6 subline in vivo was evaluated. Compared to mice bearing parental B16-BL6 tumor cells, the adoptive transfer of LAK cells and rIL2 significantly reduced formation of experimental metastases (P less than 0.009) and extended median survival time (P less than 0.001) of mice bearing ADM-resistant B16-BL6 tumor cells. Results suggest that immunotherapy with LAK cells and rIL2 may be a useful modality in the treatment of cancers with the MDR phenotype.

BROAD Lyα EMISSION FROM THREE NEARBY BL LACERTAE OBJECTS

International Nuclear Information System (INIS)

Stocke, John T.; Danforth, Charles W.; Perlman, Eric S.

2011-01-01

We present far-UV HST/COS spectra of four nearby BL Lac objects. BL Lac spectra are dominated by a smooth, power-law continuum which arises in a relativistic jet. However, the spectra are not necessarily featureless; weak, broad- and/or narrow-line emission is sometimes seen in high-quality optical spectra. We present detections of Lyα emission in HST/COS spectra of Mrk 421 (z = 0.030) and PKS 2005-489 (z = 0.071) as well as an archival HST/GHRS observation of Mrk 501 (z = 0.0337). Archival HST/STIS observations of PKS 2155-304 (z = 0.116) show no Lyα emission to a very low upper limit. Using the assumption that the broad-line region (BLR) clouds are symmetrically placed around the active galactic nucleus (AGN), we use these measured Lyα emission features to constrain either the relativistic Γ values for the ionizing continuum produced by the jet (in the ionization-bounded case) or the mass of warm gas (in the density-bounded case). While realistic Γ values can be obtained for all four cases, the values for Mrk 421 and PKS 2155-304 are high enough to suggest that covering factors of BLR clouds of ∼1%-2% might be required to provide consistency with earlier values of Doppler boosting and viewing angles suggested for this class of BL Lacs. This discrepancy also exists in the case of M 87, where the amount of Doppler boosting in our direction is expected to be minimal, again suggestive of a small covering factor of BLR clouds. If, as these small covering factors might suggest, the assumptions of a density-bounded model could be more correct, then the observed Lyα luminosities require that BL Lac/FR 1 nuclei possess very little warm gas (10 -4 to 10 -5 M sun ) as suggested by Guilbert et al. If these clouds are in pressure balance with a hotter (∼10 6 K) gas, the BLR contains too little mass to power the AGN by accretion alone.

Total alkaloid content in various fractions of Tabernaemonata sphaerocarpa Bl. (Jembirit) leaves

Science.gov (United States)

Salamah, N.; Ningsih, D. S.

2017-11-01

Tabernaemontana sphaerocarpa Bl. (Jembirit) is one of the Apocynaceae family plants containing alkaloid compound. Traditionally, it is used as an anti-inflammatory medicine. It is found to have a new bisindole alkaloid compound that shows a potent cytotoxic activity in human cancer. This study aimed to know the total alkaloid content in some fractions of ethanolic extract of T. sphaerocarpa Bl. leaf powder was extracted by maceration method in 70% ethanol solvent. Then, the extract was fractionated in a separatory funnel using water, ethyl acetate, and hexane. The total alkaloid content in each fraction was analyzed with visible spectrophotometric methods based on the reaction with Bromocresol Green (BCG). The total alkaloids in water fraction and ethyl acetate fraction were (0.0312±0.0009)% and (0.0281±0.0014)%, respectively. Meanwhile, the total alkaloid content in hexane was not detected. The statistical analysis, performed in SPSS, resulted in a significant difference between the total alkaloids in water fraction and ethyl acetate fraction. The total alkaloid in water fraction of T. sphaerocarpa Bl. was higher than the one in ethyl acetate fraction.

Comparative physical mapping between wheat chromosome arm 2BL and rice chromosome 4.

Science.gov (United States)

Lee, Tong Geon; Lee, Yong Jin; Kim, Dae Yeon; Seo, Yong Weon

2010-12-01

Physical maps of chromosomes provide a framework for organizing and integrating diverse genetic information. DNA microarrays are a valuable technique for physical mapping and can also be used to facilitate the discovery of single feature polymorphisms (SFPs). Wheat chromosome arm 2BL was physically mapped using a Wheat Genome Array onto near-isogenic lines (NILs) with the aid of wheat-rice synteny and mapped wheat EST information. Using high variance probe set (HVP) analysis, 314 HVPs constituting genes present on 2BL were identified. The 314 HVPs were grouped into 3 categories: HVPs that match only rice chromosome 4 (298 HVPs), those that match only wheat ESTs mapped on 2BL (1), and those that match both rice chromosome 4 and wheat ESTs mapped on 2BL (15). All HVPs were converted into gene sets, which represented either unique rice gene models or mapped wheat ESTs that matched identified HVPs. Comparative physical maps were constructed for 16 wheat gene sets and 271 rice gene sets. Of the 271 rice gene sets, 257 were mapped to the 18-35 Mb regions on rice chromosome 4. Based on HVP analysis and sequence similarity between the gene models in the rice chromosomes and mapped wheat ESTs, the outermost rice gene model that limits the translocation breakpoint to orthologous regions was identified.

Short Outlines of Books by Estonian authors / Rutt Hinrikus

Index Scriptorium Estoniae

Hinrikus, Rutt, 1946-

2007-01-01

Tutvustus: Miljutina, Tamara. Inimesed minu elus. Tallinn : Varrak, 2007 ; Soosaar, Enn. Isa ja aeg. Tallinn : Kultuurileht, 2007. (Loomingu Raamatukogu ; 5) ; Paju, Imbi. Tõrjutud mälestused. Tallinn : Eesti Entsüklopeediakirjastus, 2007 ; Kaplinski, Jaan. Seesama jõgi. Tallinn : Vagabund, 2007 ; Laanem, Tiina. Väikesed vanamehed. Tallinn : Eesti Päevalehe Kirjastus, 2007 ; Vaarandi, Debora. Aastad ja päevad. Tallinn : Tänapäev, 2006 ; Berg, Maimu. Unustatud inimesed. Tallinn : Tuum, 2007 ; Heinsaar, Mehis. Rändaja õnn. Tallinn : Verb, 2007

Short outlines of books by Estonian authors / Janika Kronberg, Rutt Hinrikus

Index Scriptorium Estoniae

Kronberg, Janika, 1963-

2004-01-01

Tutvustus: Baturin, Nikolai. Kentaur. Tallinn : Eesti Raamat, 2003 ; Kaplinski, Jaan. Isale. Tallinn : Varrak, 2003 ; Jaks, Ilmar. Pimedus. Tartu : Ilmamaa, 2003 ; Ivask, Ivar. Tähtede tähendust tunda. Tartu : Ilmamaa, 2003 ; Vint, Toomas. Minu abielu prostituudiga. Tallinn : Eesti Keele Sihtasutus, 2003 ; Ehin, Kristiina. Luigeluulinn. Tallinn : Huma, 2004 ; Kivisildnik. Päike, mida sa õhtul teed? Tallinn : Perioodika, 2003 ; Kivisildnik. Rahvuseepos Kalevipoeg ehk armastus. Tallinn : Tuum, 2003 ; Veidemann, Rein. Lastekodu. Tallinn : Eesti Keele Sihtasutus, 2003 ; Park, Eeva. Lõks lõpmatuses. Tallinn : Tänapäev, 2003 ; Traat, Mats. Islandi suvi. Tartu : Ilmamaa, 2003 ; Kauksi Ülle. Uibu. Tartu : Kauksi Ülle Mänedsment, 2003 ; Kross, Jaan. Kallid kaasteelised. Tallinn : Eesti Keele Sihtasutus, 2003 ; Undusk, Jaan. Quevedo. Tallinn : Perioodika, 2003

Short outlines of books by Estonian authors / Janika Kronberg, Rutt Hinrikus

Index Scriptorium Estoniae

Kronberg, Janika, 1963-

2008-01-01

Arvustus: Afanasjev, Vahur. Kosmos. Tallinn : Jutulind, 2008 ; Hvostov, Andrei. Võõrad lood. Tallinn : Tänapäev, 2008 ; Lauli, Olle. Niguliste õpilased. Tallinn : Verb, 2007 ; Rooste, Jürgen. Tavaline eesti idioot. Pärnu : Ji, 2008 ; Talvet, Jüri. Silmad peksavad une seinu. Tartu : Ilmamaa, 2008 ; Beekman, Aimée. Proovielu. Tallinn : Varrak, 2008 ; Kivi, Aita. Lähedal. Tallinn : Ajakirjade Kirjastus, 2008 ; Beekman, Vladimir. Alles see oli. Tallinn : Tänapäev, 2008 ; Viiding, Elo. Püha Maama. Tallinn : Tuum, 2008 ; Nõu, Helga. Peaaegu geenius ehk Schrödingeri kassi otsimas. Tallinn : Atlex, 2008 ; Unt, Lii. Parim näitleja linnas. Varanasi päevaraamat. Tallinn : Eesti Ekspressi Kirjastus, 2007 ; Sild, Ivar. Tantsiv linn. Tallinn : Tuum, 2007

Construction of a Wide-range High-resolution Beamline BL05 in NewSUBARU for Soft X-ray Spectroscopic Analysis on Industrial Materials

International Nuclear Information System (INIS)

Kanda, K; Hasegawa, T; Uemura, M; Niibe, M; Haruyama, Y; Motoyama, M; Amemiya, K; Fukushima, S; Ohta, T

2013-01-01

A material analysis beamline which is designed to useable in the wide energy range, 50∼4000 eV for the various industrial demands, was constructed at BL05 in NewSUBARU for industrial companies' use in cooperation with the Laboratory of Advanced Science and Technology for Industry (LASTI), University of Hyogo and well-informed researchers in the industrial world. BL05 consists of two branch lines, which is mounted with a double crystal monochromator at BL05A and grating monochromator at BL05B. XAFS measurements in the total electron yield mode and partial fluorescence yield mode using a silicon drift detector can be performed at the both branch lines. In addition, the photoelectron spectra can be measured at BL05B. The maintenance and management of BL05 are performed by Synchrotron Analysis LLC (SALLC), which is a consortium of user companies of BL05, under the supervision of the LASTI staff. If industrial users want help with measurements at BL05, operators of SALLC can assist them.

Construction of a Wide-range High-resolution Beamline BL05 in NewSUBARU for Soft X-ray Spectroscopic Analysis on Industrial Materials

Science.gov (United States)

Kanda, K.; Hasegawa, T.; Uemura, M.; Niibe, M.; Haruyama, Y.; Motoyama, M.; Amemiya, K.; Fukushima, S.; Ohta, T.

2013-03-01

A material analysis beamline which is designed to useable in the wide energy range, 50~4000 eV for the various industrial demands, was constructed at BL05 in NewSUBARU for industrial companies' use in cooperation with the Laboratory of Advanced Science and Technology for Industry (LASTI), University of Hyogo and well-informed researchers in the industrial world. BL05 consists of two branch lines, which is mounted with a double crystal monochromator at BL05A and grating monochromator at BL05B. XAFS measurements in the total electron yield mode and partial fluorescence yield mode using a silicon drift detector can be performed at the both branch lines. In addition, the photoelectron spectra can be measured at BL05B. The maintenance and management of BL05 are performed by Synchrotron Analysis LLC (SALLC), which is a consortium of user companies of BL05, under the supervision of the LASTI staff. If industrial users want help with measurements at BL05, operators of SALLC can assist them.

Tõhusad tükid teismeliste poiste raamaturiiulis / Aidi Vallik

Index Scriptorium Estoniae

Vallik, Aidi, 1971-

2007-01-01

Tutvustus: Townsend, Sue. Salajane päevik. Tallinn : Tänapäev, 2002 ; Jacobsson, Anders, Olsson, Sören. Emanuel. Tallinn : Hotger, 2002 ; Brennan, Herbie. Haldjasõjad. Tallinn : Varrak, 2005 ; Paolini, Christopher. Eragon. Tallinn : Pegasus, 2005 ; Paolini, Christopher. Vanem. Tallinn : Pegasus, 2006 ; Vallik, Aidi. Narkohollo ehk Florose vabastamine. Tartu : Lugu-Loo, 2006 ; Schlüter, Andreas. Laste linn. Tallinn : Tormikiri, 2005 ; Schlüter, Andreas. Rööv. Tallinn : Tormikiri, 2005 ; Sachar, Lois. Augud. Tallinn : Draakon ja Kuu, 2005 ; Rannap, Jaan. Roheline kindlus. Tartu : Tiritamm, 2006 ; Henno, Sass. Mina olin siin. Tallinn : Eesti Päevalehe Kirjastus, 2005

Effect of ketamine on exploratory behaviour in BALB/C and C57BL/6 mice.

Science.gov (United States)

Akillioglu, Kubra; Melik, Emine Babar; Melik, Enver; Boga, Ayper

2012-01-01

In this study, we evaluated the effect of ketamine on exploratory locomotion behaviours in the Balb/c and C57BL/6 strains of mice, which differ in their locomotion behaviours. Intraperitoneal administration of ketamine at three different doses (1, 5 or 10 mg/kg, 0.1 ml/10 gr body weight) was performed on adult male Balb/c and C57BL/6 mice. The same volume of saline was applied to the control group. The open-field and elevated plus maze apparatus were used to evaluate exploratory locomotion. In the open-field test, Balb/c mice less spend time in the centre of the field and was decreased locomotor activity compared to C57BL/6 mice (pmice at 10 mg/kg dose caused an increase in locomotor activity and an increase in the amount of time spent in the centre in the open-field test, compared to the control group (pmice, ketamine treatment (1 and 10 mg/kg) decreased locomotor activity (pmice, the three different doses of ketamine application each caused a decrease in the frequency of centre crossing (pmice compared to C57BL/6 mice (pmice at 10 mg/kg dose caused an increase in the open-arm activity (pmice (pmice. In contrast, a subanaesthetic dose of ketamine decreased exploratory locomotion in C57BL/6 mice. In conclusion, hereditary factors may play an important role in ketamine-induced responses. Copyright © 2011 Elsevier Inc. All rights reserved.

Seitse raamatut ühtmoodi loodusest, kuid kõik erinevad / Ulvar Käärt, Mari Klein

Index Scriptorium Estoniae

Käärt, Ulvar, 1982-

2009-01-01

Arvustus: Järva, Jaanus. Looduse aasta. Tallinn : Varrak, 2008; Järva, Jaanus. Raba : vaikuses ja varjus. Tallinn : Pegasus, 2008; Savisaar, Remo. Loodus kutsub. Tallinn : Varrak, 2008; Relve, Hendrik. Eesti looduse vägi. Tallinn : Koolibri, 2008; Tartes, Urmas, Põder, Jaak. Legendiloomad. Tallinn : Varrak, 2008; Eesti maastikud. Tallinn : Tänapäev, 2008; Veedla, Peep. Lindudega sõbraks / pildid joonistanud Triinu Ootsing. Tallinn : Berit Grupp, 2008

The Optical Microvariability and Spectral Changes of the BL ...

Indian Academy of Sciences (India)

strong bluer-when-brighter chromatism was found while different spectral behaviours were found on intranight time scales. Key words. BL lacertae objects: individual (S5 0716+714)—galaxies: active—galaxies: photometry. 1. Introduction. Since the development of CCD in the 80s, microvariability of blazars has been.

Short outlines of books by Estonian authors / Brita Melts, Rutt Hinrikus and Janika Kronberg

Index Scriptorium Estoniae

Melts, Brita

2012-01-01

Arvustus: Helme, Peeter. Varastatud aja lõpus. Tallinn : Tuum, 2011 ; Jõerüüt, Jaak. Kõik luuletused. Tallinn : Eesti Keele Sihtasutus, 2011 ; Kareva, Doris. Sa pole üksi. Tallinn : Verb, 2011 ; Paju, Imbi. Soome lahe õed : vaadates teiste valu. Tallinn : Hea lugu, 2011 ; Pervik, Aino. Matlena teekond. Tallinn : Mustvalge Kirjastus, 2010 ; Raud, Rein. Hotell Amalfi. Tallinn : Tuum, 2011 ; Sommer, Lauri. Räestu raamat. Tallinn : Menu Kirjastus, 2012 ; Kasemaa. Andrus. Leskede kadunud maailm. Tallinn : Varrak, 2012 ; Teede, Andra. Käigud. Pärnu : Jumalikud Ilmutused, 2011

Estonian authors / Janika Kronberg, Rutt Hinrikus

Index Scriptorium Estoniae

Kronberg, Janika, 1963-

2007-01-01

Tutvustus: Mattheus, Ülo.¡India armastus. Tallinn : Eesti Keele Sihtasutus, 2006 ;¡Teder,¡Tarmo. Onanistid. Tallinn :¡Tuum, 2006 ;¡Hirv, Indrek. Surmapõletaja. Tallinn :¡Tuum, 2006 ;¡Hvostov, Andrei. Henrik : näidend 12-s pildis. Tallinn : Kultuurileht, 2006. (Loomingu Raamatukogu ;¡20) ;¡Traat,¡Mats. Naised ja pojad. Tallinn : Looming, 2006, nr. 2-5 ;¡Traat, Mats. Sarviku armastus. Tallinn :¡Looming, 2006, nr. 11 ;¡Kaardipakk II. Tallinn : Näo Kirik, 2006 ;¡Kivirähk,¡Andrus. Mees, kes teadis ussisõnu. Tallinn :¡Eesti Keele Sihtasutus, 2007 ;¡Õunapuu,¡Ervin. Meie igapäevane jää :¡eesti gootika III. Tallinn : Varrak, 2006 ;¡Ehlvest, Jüri. Palverännak. Tallinn :¡Tuum, 2005

StagBL : A Scalable, Portable, High-Performance Discretization and Solver Layer for Geodynamic Simulation

Science.gov (United States)

Sanan, P.; Tackley, P. J.; Gerya, T.; Kaus, B. J. P.; May, D.

2017-12-01

StagBL is an open-source parallel solver and discretization library for geodynamic simulation,encapsulating and optimizing operations essential to staggered-grid finite volume Stokes flow solvers.It provides a parallel staggered-grid abstraction with a high-level interface in C and Fortran.On top of this abstraction, tools are available to define boundary conditions and interact with particle systems.Tools and examples to efficiently solve Stokes systems defined on the grid are provided in small (direct solver), medium (simple preconditioners), and large (block factorization and multigrid) model regimes.By working directly with leading application codes (StagYY, I3ELVIS, and LaMEM) and providing an API and examples to integrate with others, StagBL aims to become a community tool supplying scalable, portable, reproducible performance toward novel science in regional- and planet-scale geodynamics and planetary science.By implementing kernels used by many research groups beneath a uniform abstraction layer, the library will enable optimization for modern hardware, thus reducing community barriers to large- or extreme-scale parallel simulation on modern architectures. In particular, the library will include CPU-, Manycore-, and GPU-optimized variants of matrix-free operators and multigrid components.The common layer provides a framework upon which to introduce innovative new tools.StagBL will leverage p4est to provide distributed adaptive meshes, and incorporate a multigrid convergence analysis tool.These options, in addition to a wealth of solver options provided by an interface to PETSc, will make the most modern solution techniques available from a common interface. StagBL in turn provides a PETSc interface, DMStag, to its central staggered grid abstraction.We present public version 0.5 of StagBL, including preliminary integration with application codes and demonstrations with its own demonstration application, StagBLDemo. Central to StagBL is the notion of an

Junctional Adhesion Molecule (JAM)-C Deficient C57BL/6 Mice Develop a Severe Hydrocephalus

Science.gov (United States)

Liebner, Stefan; Mittelbronn, Michel; Deutsch, Urban; Enzmann, Gaby; Adams, Ralf H.; Aurrand-Lions, Michel; Plate, Karl H.; Imhof, Beat A.; Engelhardt, Britta

2012-01-01

The junctional adhesion molecule (JAM)-C is a widely expressed adhesion molecule regulating cell adhesion, cell polarity and inflammation. JAM-C expression and function in the central nervous system (CNS) has been poorly characterized to date. Here we show that JAM-C−/− mice backcrossed onto the C57BL/6 genetic background developed a severe hydrocephalus. An in depth immunohistochemical study revealed specific immunostaining for JAM-C in vascular endothelial cells in the CNS parenchyma, the meninges and in the choroid plexus of healthy C57BL/6 mice. Additional JAM-C immunostaining was detected on ependymal cells lining the ventricles and on choroid plexus epithelial cells. Despite the presence of hemorrhages in the brains of JAM-C−/− mice, our study demonstrates that development of the hydrocephalus was not due to a vascular function of JAM-C as endothelial re-expression of JAM-C failed to rescue the hydrocephalus phenotype of JAM-C−/− C57BL/6 mice. Evaluation of cerebrospinal fluid (CSF) circulation within the ventricular system of JAM-C−/− mice excluded occlusion of the cerebral aqueduct as the cause of hydrocephalus development but showed the acquisition of a block or reduction of CSF drainage from the lateral to the 3rd ventricle in JAM-C−/− C57BL/6 mice. Taken together, our study suggests that JAM-C−/− C57BL/6 mice model the important role for JAM-C in brain development and CSF homeostasis as recently observed in humans with a loss-of-function mutation in JAM-C. PMID:23029139

Macrophage-dependent clearance of systemically administered B16BL6-derived exosomes from the blood circulation in mice

OpenAIRE

Imai, Takafumi; Takahashi, Yuki; Nishikawa, Makiya; Kato, Kana; Morishita, Masaki; Yamashita, Takuma; Matsumoto, Akihiro; Charoenviriyakul, Chonlada; Takakura, Yoshinobu

2015-01-01

Previous studies using B16BL6-derived exosomes labelled with gLuc–lactadherin (gLuc-LA), a fusion protein of Gaussia luciferase (a reporter protein) and lactadherin (an exosome-tropic protein), showed that the exosomes quickly disappeared from the systemic circulation after intravenous injection in mice. In the present study, the mechanism of rapid clearance of intravenously injected B16BL6 exosomes was investigated. gLuc-LA-labelled exosomes were obtained from supernatant of B16BL6 cells aft...

Emilie Bláhová (13. 6. 1931 - 9. 10. 2016)

Czech Academy of Sciences Publication Activity Database

Chromá, Martina

2017-01-01

Roč. 140, 1-2 (2017), s. 275-277 ISSN 0024-4457 Institutional support: RVO:68378017 Keywords : Bláhová, Emilie * obituary * paleoslavistics Subject RIV: AI - Linguistics OBOR OECD: Specific languages

Soft X-Ray Observations of a Complete Sample of X-Ray--selected BL Lacertae Objects

Science.gov (United States)

Perlman, Eric S.; Stocke, John T.; Wang, Q. Daniel; Morris, Simon L.

1996-01-01

We present the results of ROSAT PSPC observations of the X-ray selected BL Lacertae objects (XBLs) in the complete Einstein Extended Medium Sensitivity Survey (EM MS) sample. None of the objects is resolved in their respective PSPC images, but all are easily detected. All BL Lac objects in this sample are well-fitted by single power laws. Their X-ray spectra exhibit a variety of spectral slopes, with best-fit energy power-law spectral indices between α = 0.5-2.3. The PSPC spectra of this sample are slightly steeper than those typical of flat ratio-spectrum quasars. Because almost all of the individual PSPC spectral indices are equal to or slightly steeper than the overall optical to X-ray spectral indices for these same objects, we infer that BL Lac soft X-ray continua are dominated by steep-spectrum synchrotron radiation from a broad X-ray jet, rather than flat-spectrum inverse Compton radiation linked to the narrower radio/millimeter jet. The softness of the X-ray spectra of these XBLs revives the possibility proposed by Guilbert, Fabian, & McCray (1983) that BL Lac objects are lineless because the circumnuclear gas cannot be heated sufficiently to permit two stable gas phases, the cooler of which would comprise the broad emission-line clouds. Because unified schemes predict that hard self-Compton radiation is beamed only into a small solid angle in BL Lac objects, the steep-spectrum synchrotron tail controls the temperature of the circumnuclear gas at r ≤ 1018 cm and prevents broad-line cloud formation. We use these new ROSAT data to recalculate the X-ray luminosity function and cosmological evolution of the complete EMSS sample by determining accurate K-corrections for the sample and estimating the effects of variability and the possibility of incompleteness in the sample. Our analysis confirms that XBLs are evolving "negatively," opposite in sense to quasars, with Ve/Va = 0.331±0.060. The statistically significant difference between the values for X

The ultraviolet to X-ray continua of BL Lac objects

International Nuclear Information System (INIS)

George, I.M.; Warwick, R.S.; McHardy, I.M.

1988-01-01

The results from EXOSAT observations of three X-ray bright BL Lacertae objects, Mrk 501, 1218 + 304 and Mrk 180 are presented. All three sources have soft power-law X-ray spectra with low-energy cut-offs consistent with absorption in the line-of-sight gas column density through our own galaxy. The three objects also exhibit significant spectral variability in the X-ray band on time-scales ranging from a few days to a year. In each case, X-ray flux and spectral index appear to be correlated, in the sense that the X-ray spectrum hardens as the source brightens. The intrinsic ultraviolet to X-ray spectrum of these and several other X-ray bright BL Lac objects can be modelled as a power-law continuum of energy index ∼1.0 below about 0.1 keV, above which the spectral slope steepens. (author)

Type II Cepheids: evidence for Na-O anticorrelation for BL Her type stars?

Science.gov (United States)

Kovtyukh, V.; Yegorova, I.; Andrievsky, S.; Korotin, S.; Saviane, I.; Lemasle, B.; Chekhonadskikh, F.; Belik, S.

2018-06-01

The chemical composition of 28 Population II Cepheids and one RR Lyrae variable has been studied using high-resolution spectra. The chemical composition of W Vir variable stars (with periods longer than 8 d) is typical for the halo and thick disc stars. However, the chemical composition of BL Her variables (with periods of 0.8-4 d) is drastically different, although it does not differ essentially from that of the stars belonging to globular clusters. In particular, the sodium overabundance ([Na/Fe] ≈ 0.4) is reported for most of these stars, and the Na-O anticorrelation is also possible. The evolutionary tracks for BL Her variables (with a progenitor mass value of 0.8 solar masses) indicate that mostly helium-overabundant stars (Y = 0.30-0.35) can fall into the instability strip region. We suppose that it is the helium overabundance that accounts not only for the existence of BL Her variable stars but also for the observed abnormalities in the chemical composition of this small group of pulsating variables.

Relativistic Beaming and Orientation Effects in BL Lacertae Objects ...

Indian Academy of Sciences (India)

tation paradigm for high peaked and low-peaked BL Lacs (X-ray and radio selected .... consequences of relativistic beaming and geometric projection were studied in high- ... model. If we assume α = 0 (for synchrotron self-absorbed sources) and β ∼ 1, it can .... for RBL and XBL subsamples at confidence level of ∼ 95.0%.

USING THE METHODS OF WAVELET ANALYSIS AND SINGULAR SPECTRUM ANALYSIS IN THE STUDY OF RADIO SOURCE BL LAC

OpenAIRE

Donskykh, G. I.; Ryabov, M. I.; Sukharev, A. I.; Aller, M.

2014-01-01

We investigated the monitoring data of extragalactic source BL Lac. This monitoring was held withUniversityofMichigan26-meter radio  telescope. To study flux density of extragalactic source BL Lac at frequencies of 14.5, 8 and 4.8 GHz, the wavelet analysis and singular spectrum analysis were used. Calculating the integral wavelet spectra allowed revealing long-term  components  (~7-8 years) and short-term components (~ 1-4 years) in BL Lac. Studying of VLBI radio maps (by the program Mojave) ...

Lugupeetud emakeeleõpetaja! / Martin Ehala

Index Scriptorium Estoniae

Ehala, Martin, 1963-

2006-01-01

Tutvustatakse eesti keele õpikuid: Ehala, Martin. Eesti keele struktuur. Tallinn, 2001 ; Ehala, Martin. Kirjutamise kunst. Tallinn, 2000 ; Ehala, Martin. Eesti kirjakeel. Tallinn, 2002 ; Madisso, Maia. Keele- ja tekstiharjutusi abiturientidele. Tallinn, 2002 ; Ehala, Martin ; Veismann, Tiina jt. Noor keelekasutaja. Tallinn, 2005

Sulle sponde del Mediterraneo alla ricerca dell’amore perduto

DEFF Research Database (Denmark)

Chemi, Tatiana

2002-01-01

Review to the Odin Teatret’s last performance, Sale, from a short story of the Italian novelist Antonio Tabucchi. A melancholic and self-ironic love story.......Review to the Odin Teatret’s last performance, Sale, from a short story of the Italian novelist Antonio Tabucchi. A melancholic and self-ironic love story....

Short outlines of books by Estonian authors / Janika Kronberg, Rutt Hinrikus

Index Scriptorium Estoniae

Kronberg, Janika, 1963-

2003-01-01

Talvet, Jüri. ElegÍa Estonia y otros poemas = Eesti eleegia ja teisi luuletusi / Spanish transl. by the author and Albert L̉zaro Tinaut. Ciudad de València : Palmart, 2002 ; Ehlvest, Jüri. Hobune eikuskilt. Tallinn : Tänapäev, 2002 ; Raudam, Toomas. Saint-Prousti vastu. Tallinn : Eesti Keele Sihtasutus, 2002 ; Tode, Emil. Raadio. Tallinn : Eesti Keele Sihtasutus, 2002 ; Vene, Ilmar. Pahustumine ehk Uusaja olemus. Tallinn : Eesti Keele Sihtasutus, 2002 ; Annus, Epp. Kuidas kirjutada aega. Tallinn : Underi ja Tuglase Kirjanduskeskus, 2002 ; Lepik, Kalju. Valguse riie ei vanu. Kogutud luuletused 1938-1999 ; Barker, Matt. Waanenburgi tapatalgud. Tartu : EYS Veljesto, 2002 ; Kesküla, Kalev. Platoni riik. Tallinn : Tuum, 2002 ; Vahing, Vaino. Mängud ja kõnelused. Tallinn : Eesti Keele Sihtasutus, 2002 ; Tuulik, Jüri. Üksik lind mere kohal. Tallinn : Maalehe Raamat, 2002 ; Tätte, Jaan. Näidendid. Tallinn : Maalehe Raamat, 2002 ; Kareva, Doris. Mandragora. Tallinn : Huma, 2002

Short outlines of books by Estonian authors / Berk Vaher, Aare Pilv

Index Scriptorium Estoniae

Vaher, Berk, 1975-

2005-01-01

Tutvustus: Raudam, Toomas. Nips. Tallinn : Eesti Keele Sihtasutus, 2004 ; Ilus Armin : eesti lühiproosat 1987-2002 / koost. Udo Uibo. Tallinn : Varrak, 2004 ; Ehlvest, Jüri von. Rahuldus. Tartu : Ilukirjandus, 2004 ; Ki:wa. Roboti tee on nihe ; Salatühik. Tallinn : Eesti Kunstimuuseum, 2004 ; Sommer, Lauri. Nõidade õrnus. Sännä : Tiivaalune, 2004 ; Kalkun, Andreas. Pääväraamat. Tartu : Erakkond, 2004 ; Jõerüüt, Jaak. Uus raamat. Tallinn : Tuum, 2004 ; Krull, Hasso. Meeter ja Demeeter. Tallinn : Vagabund, 2004 ; Kõiv, Madis. Päev. Tartu : Akkon, 2004 ; Mihkelson, Ene. Uroboros. Tallinn : Tuum, 2004 ; Soomets, Triin. Toormaterjal. Tallinn : Verb, 2004 ; Vaher, Berk. Sekeldaja päevad. Tallinn : Tuum, 2004

BL-7010 demonstrates specific binding to gliadin and reduces gluten-associated pathology in a chronic mouse model of gliadin sensitivity.

Directory of Open Access Journals (Sweden)

Justin L McCarville

Full Text Available Celiac disease (CD is an autoimmune disorder in individuals that carry DQ2 or DQ8 MHC class II haplotypes, triggered by the ingestion of gluten. There is no current treatment other than a gluten-free diet (GFD. We have previously shown that the BL-7010 copolymer poly(hydroxyethyl methacrylate-co-styrene sulfonate (P(HEMA-co-SS binds with higher efficiency to gliadin than to other proteins present in the small intestine, ameliorating gliadin-induced pathology in the HLA-HCD4/DQ8 model of gluten sensitivity. The aim of this study was to investigate the efficiency of two batches of BL-7010 to interact with gliadin, essential vitamins and digestive enzymes not previously tested, and to assess the ability of the copolymer to reduce gluten-associated pathology using the NOD-DQ8 mouse model, which exhibits more significant small intestinal damage when challenged with gluten than HCD4/DQ8 mice. In addition, the safety and systemic exposure of BL-7010 was evaluated in vivo (in rats and in vitro (genetic toxicity studies. In vitro binding data showed that BL-7010 interacted with high affinity with gliadin and that BL-7010 had no interaction with the tested vitamins and digestive enzymes. BL-7010 was effective at preventing gluten-induced decreases in villus-to-crypt ratios, intraepithelial lymphocytosis and alterations in paracellular permeability and putative anion transporter-1 mRNA expression in the small intestine. In rats, BL-7010 was well-tolerated and safe following 14 days of daily repeated administration of 3000 mg/kg. BL-7010 did not exhibit any mutagenic effect in the genetic toxicity studies. Using complementary animal models and chronic gluten exposure the results demonstrate that administration of BL-7010 is effective and safe and that it is able to decrease pathology associated with gliadin sensitization warranting the progression to Phase I trials in humans.

Short outlines of books by Estonian authors / Brita Melts, Rutt Hinrikus, Maire Iro and Maret Vaher

Index Scriptorium Estoniae

2013-01-01

Arvustus: Pärtna, Maarja. Läved ja tüved. Tallinn : Eesti Keele Sihtasutus, 2013 ; Sauter, Peeter. Ära jäta mind rahule. Tallinn : P. Sauter, 2012 ; Viiding, Elo. Teised. Tallinn : Tuum, 2012 ; Mathura. Kumalasepäev. Lelle : Allikaäärne, 2012 ; Kadastik, Mart. Kevad saabub sügisel. Tallinn : Varrak, 2013 ; Mutt, Mihkel. Kooparahvas läheb ajalukku. Tallinn : Fabian, 2012 ; Hargla, Indrek. Apteeker Melchior ja Pirita kägistaja. Tallinn : Varrak, 2013 ; Raud, Rein. Rekonstruktsioon. Tallinn : Mustvalge Kirjastus, 2012 ; Toona, Elin. Into exile : a life story of war and peace. Woodsville (N.H.) : Lakeshore Press, 2013 ; Berg, Maimu. Moemaja. Tartu : Petrone Print, 2012 ; Kareva, Doris, Rooste, Jürgen. Elutants. Tallinn : Verb, 2013 ; Ehin, Kristiina. Paleontoloogi päevaraamat. Tartu : Petrone Print, 2013 ; Maria Lee. Stereomeetria. Tallinn : Verb, 2012

C57BL/6 mice need MHC class II Aq to develop collagen-induced arthritis dependent on autoreactive T cells.

Science.gov (United States)

Bäcklund, Johan; Li, Cuiqin; Jansson, Erik; Carlsen, Stefan; Merky, Patrick; Nandakumar, Kutty-Selva; Haag, Sabrina; Ytterberg, Jimmy; Zubarev, Roman A; Holmdahl, Rikard

2013-07-01

Collagen-induced arthritis (CIA) has traditionally been performed in MHC class II A(q)-expressing mice, whereas most genetically modified mice are on the C57BL/6 background (expressing the b haplotype of the major histocompatibility complex (MHC) class II region). However, C57BL/6 mice develop arthritis after immunisation with chicken-derived collagen type II (CII), but arthritis susceptibility has been variable, and the immune specificity has not been clarified. To establish a CIA model on the C57BL/6 background with a more predictable and defined immune response to CII. Both chicken and rat CII were arthritogenic in C57BL/6 mice provided they were introduced with high doses of Mycobacterium tuberculosis adjuvant. However, contaminating pepsin was strongly immunogenic and was essential for arthritis development. H-2(b)-restricted T cell epitopes on chicken or rat CII could not be identified, but expression of A(q) on the C57BL/6 background induced T cell response to the CII260-270 epitope, and also prolonged the arthritis to be more chronic. The putative (auto)antigen and its arthritogenic determinants in C57BL/6 mice remains undisclosed, questioning the value of the model for addressing T cell-driven pathological pathways in arthritis. To circumvent this impediment, we recommend MHC class II congenic C57BL/6N.Q mice, expressing A(q), with which T cell determinants have been thoroughly characterised.

PG 1553 + 11 - A bright optically selected BL Lacertae object

International Nuclear Information System (INIS)

Falomo, R.; Treves, A.

1990-01-01

A detailed study of the bright optically selected BL Lac object PG 1553 + 11 is presented. UV observations, obtained during a high state of the source, together with simultaneous optical spectrophotometry and near-IR photometry, allow the spectral flux distribution to be examined from 8 x 10 to the 13th to 2.5 x 10 to the 15th Hz. This distribution is compared with that derived from quasi-simultaneous observations obtained when the source was a factor of about 3 fainter. It is found that, in the higher state, the spectrum can be described by two power laws connected by a break at about 10 to the 15th Hz, while in the low state the shape is more complex. The overall spectrum of the object is compared with the average energy distribution of X-ray and radio-selected BL Lac objects, showing that it is closer to the former class. 25 refs

miR expression in MYC-negative DLBCL/BL with partial trisomy 11 is similar to classical Burkitt lymphoma and different from diffuse large B-cell lymphoma.

Science.gov (United States)

Zajdel, Michalina; Rymkiewicz, Grzegorz; Chechlinska, Magdalena; Blachnio, Katarzyna; Pienkowska-Grela, Barbara; Grygalewicz, Beata; Goryca, Krzysztof; Cieslikowska, Maria; Bystydzienski, Zbigniew; Swoboda, Pawel; Walewski, Jan; Siwicki, Jan Konrad

2015-07-01

Fast and reliable differential diagnosis of Burkitt lymphoma (BL) vs. diffuse large B cell lymphoma (DLBCL) is of major importance for therapeutic decisions and patient outcome. Aggressive B cell non-Hodgkin lymphomas (B-NHLs) that do not belong to the abovementioned entities were categorized by the current WHO lymphoma classification as "B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and BL" (DLBCL/BL). We have recently described a DLBCL/BL subgroup with recurrent chromosome 11q aberrations, resembling BL (B-NHLs[11q]). Here, we analyzed 102 prospectively collected fine needle aspirates from patients with aggressive B-NHLs in order to investigate the potential of microRNA (miR)-155, its precursor BIC, as well as miR-21 and miR-26a to differentiate BL from DLBCL, and from DLBCL/BL that include B-NHLs[11q]. Both BL and DLBCL/BL cases, including B-NHLs[11q], demonstrated significantly lower expression levels of miR-155/BIC, miR-21, and miR-26a compared to primary DLBCL. In conclusion, the miRs expression in B-NHLs[11q] provides a new suggestion, in addition to pathomorphological and clinical similarities between classical, i.e., MYC translocation-positive BL, and B-NHLs[11q], to recognize the B-NHLs[11q] subgroup of DLBCL/BL category as a MYC translocation-negative variant of BL in most cases, and points to the potential utility of miR-155/BIC/miR-21/miR-26a for the differential diagnosis of a heterogeneous category of DLBCL/BL.

Infrared polarimetry and photometry of BL Lac objects

International Nuclear Information System (INIS)

Impey, C.D.; Williams, P.M.

1984-01-01

Photometry and polarimetry in the JHK wavebands have now been obtained for 25 BL Lac objects. Several new objects have been monitored for periods of up to five days, and accumulated data is sufficient for a statistical analysis of polarization properties. The selection effects operating on this sample are examined first. A power-law spectrum is consistent with the spectra of all but three objects. A number of important new results are reported. (author)

Lammasinimene, liblikmees ja karunaine : maagilisest realismist eesti kirjanduse näitel / Andrus Org

Index Scriptorium Estoniae

Org, Andrus

2007-01-01

Maagilisest realismist kolme eesti romaani põhjal: Karl Rumori "Krutsifiks" (Tallinn : Eesti Raamat, 1989), Mehis Heinsaare "Härra Pauli kroonikad" (Tallinn : Perioodika, 2001), Nikolai Baturini triloogia "Karu süda" (Tallinn : Eesti Raamat, 1989), "Kartlik Nikas, lõvilakkade kammija" (Tallinn : Eesti Raamat, 1993), "Kentaur" (Tallinn : Eesti Raamat, 2003)

Screening of sugarcane somaclones of variety bl4 for agronomic characteristics

International Nuclear Information System (INIS)

Raza, S.; Qamarunnisa, S.; Jamil, I.

2014-01-01

Considering the environmental conditions of Pakistan where sugarcane breeding is constrained due to non viable fuzz (seeds) production. Somaclonal variation could prove to be a useful tool to overcome the difficulties in cane breeding. In the present study, 324 sugarcane somaclones regenerated from immature leaf roll callus of sugarcane variety BL4 were evaluated for their yield and yield contributing characters and the quality traits of cane. The field trial of somaclones showed variation in 160 somaclones from the mother plant in at least one character observed. Most of the somaclones showed variation in weight of stalks per plant; however, only twenty four out of 89 clones showed increase in the weight of the stalks per clump. The second highly variable trait was the number of stalks, 88 plants showed either increase or decrease in the number of stalks. It is noteworthy that the sucrose accumulation was not increased in any of the somaclones. Twenty one somaclones were selected for their increased yield potential. The comparative performance of these selected clones revealed that clones 'K-250, K-265, K-251, K-109, K-106, K-300 and K-315 gave better sugar yield /plant as compared to BL4. Maximum sugar yield/plant was observed in Clone 'K-250' (2.5 Kg) followed by K-265 (2.44 Kg), whereas the average sugar yield of BL4 was 1.2 Kg/plant. (author)

BL Lacertae Objects Beyond Redshift 1.3 - UV-to-NIR Photometry and Photometric Redshift for Fermi/LAT Blazars

Science.gov (United States)

Rau, A.; Schady, P.; Greiner, J.; Salvato, M.; Ajello, M.; Bottacini, E.; Gehrels, N.; Afonso, P. M. J.; Elliott, J.; Filgas, R.;

Synchrotron total reflection X-ray fluorescence at BL-16 microfocus beamline of Indus-2

Energy Technology Data Exchange (ETDEWEB)

Tiwari, M. K., E-mail: mktiwari@rrcat.gov.in; Singh, A. K., E-mail: mktiwari@rrcat.gov.in; Das, Gangadhar, E-mail: mktiwari@rrcat.gov.in; Chowdhury, Anupam, E-mail: mktiwari@rrcat.gov.in; Lodha, G. S., E-mail: mktiwari@rrcat.gov.in [Indus Synchrotrons Utilisation Division, Raja Ramanna Centre for Advanced Technology, Indore-452013 (India)

2014-04-24

Determination of ultra trace elements is important in many disciplines both in basic and applied sciences. Numerous applications show their importance in medical science, environmental science, materials science, food processing and semiconductor industries and in maintaining the quality control of ultra pure chemicals and reagents. We report commissioning of a synchrotron based total reflection x-ray fluorescence (TXRF) facility on the BL-16 microfocus beamline of Indus-2. This paper describes the performance of the BL-16 TXRF spectrometer and the detailed description of its capabilities through examples of measured results.

Constraining the red shifts of TeV BL Lac objects

Science.gov (United States)

Qin, Longhua; Wang, Jiancheng; Yan, Dahai; Yang, Chuyuan; Yuan, Zunli; Zhou, Ming

2018-01-01

We present a model-dependent method to estimate the red shifts of three TeV BL Lac objects (BL Lacs) through fitting their (quasi-)simultaneous multi-waveband spectral energy distributions (SEDs) with a one-zone leptonic synchrotron self-Compton model. Considering the impact of electron energy distributions (EEDs) on the results, we use three types of EEDs to fit the SEDs: a power-law EED with exponential cut-off (PLC), a log-parabola (PLLP) EED and the broken power-law (BPL) EED. We also use a parameter α to describe the uncertainties of the extragalactic background light models, as in Abdo et al. We then use a Markov chain Monte Carlo method to explore the multi-dimensional parameter space and obtain the uncertainties of the model parameters based on the observational data. We apply our method to obtain the red shifts of three TeV BL Lac objects in the marginalized 68 per cent confidence, and find that the PLC EED does not fit the SEDs. For 3C66A, the red shift is 0.14-0.31 and 0.16-0.32 in the BPL and PLLP EEDs. For PKS1424+240, the red shift is 0.55-0.68 and 0.55-0.67 in the BPL and PLLP EEDs. For PG1553+113, the red shift is 0.22-0.48 and 0.22-0.39 in the BPL and PLLP EEDs. We also estimate the red shift of PKS1424+240 in the high stage to be 0.46-0.67 in the PLLP EED, roughly consistent with that in the low stage.

BL153 Partially Prevents High-Fat Diet Induced Liver Damage Probably via Inhibition of Lipid Accumulation, Inflammation, and Oxidative Stress

Directory of Open Access Journals (Sweden)

Jian Wang

2014-01-01

Full Text Available The present study was to investigate whether a magnolia extract, named BL153, can prevent obesity-induced liver damage and identify the possible protective mechanism. To this end, obese mice were induced by feeding with high fat diet (HFD, 60% kcal as fat and the age-matched control mice were fed with control diet (10% kcal as fat for 6 months. Simultaneously these mice were treated with or without BL153 daily at 3 dose levels (2.5, 5, and 10 mg/kg by gavage. HFD feeding significantly increased the body weight and the liver weight. Administration of BL153 significantly reduced the liver weight but without effects on body weight. As a critical step of the development of NAFLD, hepatic fibrosis was induced in the mice fed with HFD, shown by upregulating the expression of connective tissue growth factor and transforming growth factor beta 1, which were significantly attenuated by BL153 in a dose-dependent manner. Mechanism study revealed that BL153 significantly suppressed HFD induced hepatic lipid accumulation and oxidative stress and slightly prevented liver inflammation. These results suggest that HFD induced fibrosis in the liver can be prevented partially by BL153, probably due to reduction of hepatic lipid accumulation, inflammation and oxidative stress.

Inhibition of the metastatic spread and growth of B16-BL6 murine melanoma by a synthetic matrix metalloproteinase inhibitor.

Science.gov (United States)

Chirivi, R G; Garofalo, A; Crimmin, M J; Bawden, L J; Stoppacciaro, A; Brown, P D; Giavazzi, R

1994-08-01

The synthetic matrix metalloproteinase inhibitor batimastat was tested for its ability to inhibit growth and metastatic spread of the B16-BL6 murine melanoma in syngeneic C57BL/6N mice. Intraperitoneal administration of batimastat resulted in a significant inhibition in the number of lung colonies produced by B16-BL6 cells injected i.v. The effect of batimastat on spontaneous metastases was examined in mice inoculated in the hind footpad with B16-BL6 melanoma. The primary tumor was removed surgically after 26-28 days. Batimastat was administered twice a day from day 14 to day 28 (pre-surgery) or from day 26 to day 44 (post-surgery). With both protocols, the median number of lung metastases was not significantly affected, but there was a significant reduction in the weight of the metastases. Finally, the effect of batimastat was examined on s.c. growth of B16-BL6 melanoma. Batimastat administered daily, starting at day of tumor transplantation, resulted in a significant growth delay, whereas treatment starting at advanced stage tumor only reduced tumor growth marginally. Our results indicate that a matrix metalloproteinase inhibitor can not only prevent the colonization of secondary organs by B16-BL6 cells but also limit the growth of solid tumors.

Temporal characteristics of stress-induced decrease in benzodiazepine reception in C57BL/6 and BALB/c mice.

Science.gov (United States)

Yarkova, M A; Seredenin, S B

2014-10-01

We studied the duration of the drop of specific (3)H-flunitrazepam binding by synaptosomal membranes from the brain of C57Bl/6 and BALB/c mice after open-field and "contact with predator" tests. It was found that reduced benzodiazepine reception in BALB/c mice after open-field test persisted for 1.5 h, but no changes of this parameter were found in C57Bl/6 mice. After contact with predator, the binding capacity of the benzodiazepine site of GABAA receptor was reduced for 8 h in BALB/c mice and for 24 h in C57Bl/6 mice.

PHOTOMETRIC STUDIES OF THREE NEGLECTED SHORT-PERIOD CONTACT BINARIES GN BOOTIS, BL LEONIS, AND V1918 CYGNI

International Nuclear Information System (INIS)

Yang, Y.-G.; Dai, H.-F.; Qian, S.-B.

2013-01-01

We present new photometry for three short-period contact binaries, GN Boo, BL Leo, and V1918 Cyg, observed from 2008 December to 2012 April using several small telescopes in China. Photometric models were deduced from new observations using the updated Wilson-Devinney Code. The results show that GN Boo and BL Leo are W-type contact binaries, while V1918 Cyg is an A-type one. The mass ratios and fill-out factors are q = 0.320(± 0.002) and f = 5.8(± 0.1)% for GN Boo, q = 0.476(± 0.005) and f = 21.3(± 1.1)% for BL Leo, q = 0.264(± 0.002), and f = 49.7(± 0.7)% for V1918 Cyg, respectively. From the (O – C) curves, it is discovered that the orbital periods of three binaries have varied in a complicated way, i.e., cyclic oscillation for GN Boo, long-term period decrease for BL Leo, and both for V1918 Cyg. The cyclic variations for GN Boo and V1918 Cyg may probably be attributed to the magnetic activity of the primary component or light-time effect due to the third body. Meanwhile, the secular period decreases for BL Leo and V1918 Cyg may result from mass transfer from the primary to the secondary, accompanying the mass and angular momentum loss from the central system. Finally, GN Boo, BL Leo, and V1918 Cyg will evolve into deep contact binaries. Additionally, a statistical study of 37 contact binaries with decreasing periods is given. We obtained the relations of q – f and q – dln P/dt, and preliminarily determined the mass loss rate of dln M/dt from the binary system.

Stress and estrous cycle affect strategy but not performance of female C57BL/6J mice

NARCIS (Netherlands)

ter Horst, J.P.; Kentrop, J.; de Kloet, E.R.; Oitzl, M.S.

2013-01-01

Stress induces a switch in learning strategies of male C57BL/6J mice from predominantly spatial to more stimulus-response learning. To study generalization of these findings over sex, we investigated female C57BL/6J mice at three phases of the estrous cycle under non stress and acute (10 min)

A novel halophilic lipase, LipBL, showing high efficiency in the production of eicosapentaenoic acid (EPA.

Directory of Open Access Journals (Sweden)

Dolores Pérez

Full Text Available BACKGROUND: Among extremophiles, halophiles are defined as microorganisms adapted to live and thrive in diverse extreme saline environments. These extremophilic microorganisms constitute the source of a number of hydrolases with great biotechnological applications. The interest to use extremozymes from halophiles in industrial applications is their resistance to organic solvents and extreme temperatures. Marinobacter lipolyticus SM19 is a moderately halophilic bacterium, isolated previously from a saline habitat in South Spain, showing lipolytic activity. METHODS AND FINDINGS: A lipolytic enzyme from the halophilic bacterium Marinobacter lipolyticus SM19 was isolated. This enzyme, designated LipBL, was expressed in Escherichia coli. LipBL is a protein of 404 amino acids with a molecular mass of 45.3 kDa and high identity to class C β-lactamases. LipBL was purified and biochemically characterized. The temperature for its maximal activity was 80°C and the pH optimum determined at 25°C was 7.0, showing optimal activity without sodium chloride, while maintaining 20% activity in a wide range of NaCl concentrations. This enzyme exhibited high activity against short-medium length acyl chain substrates, although it also hydrolyzes olive oil and fish oil. The fish oil hydrolysis using LipBL results in an enrichment of free eicosapentaenoic acid (EPA, but not docosahexaenoic acid (DHA, relative to its levels present in fish oil. For improving the stability and to be used in industrial processes LipBL was immobilized in different supports. The immobilized derivatives CNBr-activated Sepharose were highly selective towards the release of EPA versus DHA. The enzyme is also active towards different chiral and prochiral esters. Exposure of LipBL to buffer-solvent mixtures showed that the enzyme had remarkable activity and stability in all organic solvents tested. CONCLUSIONS: In this study we isolated, purified, biochemically characterized and immobilized a

Photo-translocation of anti-HIV-1 drugs into TZM-bl cells

CSIR Research Space (South Africa)

Khanyile, T

2013-04-01

Full Text Available Targeted drug delivery into HIV-1 infected cells offers a reduction in toxicity and side effect. Using a femtosecond (fs) laser of different beam shapes anti-HIV-1 drugs are efficiently delivered into TZM-bl cells....

Characterization of (357439) 2004 BL86 on its close approach to Earth in 2015

Science.gov (United States)

Birlan, M.; Popescu, M.; Nedelcu, D. A.; Turcu, V.; Pop, A.; Dumitru, B.; Stevance, F.; Vaduvescu, O.; Moldovan, D.; Rocher, P.; Sonka, A.; Mircea, L.

2015-09-01

Context. The potentially hazardous asteroid (PHA) (357439) 2004 BL86 grazed Earth on January 26, 2015 at a distance of about 1.2 million km. This favorable geometry allowed observing it to derive its physical and dynamical parameters. (357439) 2004 BL86 was previously estimated to be a 500-m body. We study it also considering possible mechanisms that might mitigate the effect of asteroids that might become dangerous for Earth. Aims: Physical and dynamical investigations of this peculiar object were performed to be able to characterize this object. Methods: We used spectral observations obtained in the visible (V) using the Isaac Newton Telescope and in the near-infrared (NIR) using the InfraRed Telescope Facility. A complementary photometric survey during two nights was also provided by the Astronomical Observatory Cluj-Feleacu station in Romania. We anlyzed the data using reliable mathematical tools that were previously published under the acronym M4AST. Results: VNIR spectral observations classify (357439) 2004 BL86 as V-type asteroid. The mineralogical analysis reveals its similarities to howardite-eucrite-diogenite meteorites. The band analysis reveals that the object is more similar to a eucritic and howarditic composition, and that it originated from the crust of a large parent body. The analysis yields a mineralogical solution of Wo17Fs39 with an error bar of 4%. Based on the average value of the thermal albedo for V-type objects, its diameter was re-estimated to a value of 290 ± 30 m. The dynamical analysis shows a chaotical behavior of (357439) 2004 BL86. The statistics on meteorite falls show that (357439) 2004 BL86 does not appear to significantly contribute to the current howardite-eucrite-diogenite meteorite flux. For the two photometrical observing runs the following values of the rotational period and peak-to-peak amplitude were estimated for the light curves: 2.637 ± 0.024 h, 0.105 ± 0.007 mag, and 2.616 ± 0.061 h, 0.109 ± 0.018 mag

Data on morphometric analysis of the pancreatic islets from C57BL/6 and BALB/c mice

Directory of Open Access Journals (Sweden)

Thiago Aparecido da Silva

2016-09-01

Full Text Available The endocrine portion of the pancreas, which is characterized by pancreatic islets, has been widely investigated among different species. The BALB/c and C57BL/6 mice are extensively used in experimental research, and the morphometric differences in the pancreatic islets of these animals have not been evaluated so far. Thus, our data have a comparative perspective related to the morphometric analysis of area, diameters, circularity, and density of pancreatic islets from BALB/c and C57BL/6 mice. The data presented here are focused to evaluate the differences in morphology of pancreatic islets of two common laboratory mouse strains. Keywords: Pancreatic islets, Morphometry, BALB/c and C57BL/6 mice

Lugemis- ja kuulamissoovitusi lapsemeelsetele : [heliraamatud ja -plaadid lastele] / Esme Kassak

Index Scriptorium Estoniae

Kassak, Esme

2010-01-01

Arvustus: Jancis, Kaspar. Seiklus Salamandril, ehk, Morten Viksi uskumatud juhtumised lollide laevas. Tallinn : Menu Kirjastus, 2010 ; Kivirähk, Andrus. Kaka ja kevad [Helisalvestis] / loeb Ülle Kaljuste. Tallinn ; Varrak, 2010 ; Kivirähk, Andrus. Kaelkirjak [Helisalvestis] / loeb Harriet Toompere. Tallinn : Varrak, 2010 ; Tungal, Leelo. Hea lapse laulud [Helisalvestis]. Tallinn : Nõmmelill, 2010 ; Pajusaar, Priit. Lapsed, liblikad ja teised mutukad [Helisalvestis]. Tallinn : Varrak, 2010 ; Toman, Eduard. Gena ja teised : [Helisalvestis]. Tallinn : Greenroom Studio, 2010 ; Vilmusenaho, Marika. Tuulejutu viisid [Helisalvestis] / esitavad Meero Muusiku laululapsed. I.k. : Tempo Rubato, 2009 ; Raud, Eno. Sipsik : laste unejutud / loeb Salme Reek. Tallinn : Eesti Rahvusringhääling, 2010

Seven-Year Multi-Colour Optical Monitoring of BL Lacertae Object ...

Indian Academy of Sciences (India)

2016-01-27

Jan 27, 2016 ... We monitored the BL Lac object S5 0716+714 in five intermediate optical passbands from 2004 September to 2011 April. The object was active most of the time and intra-day variability was frequently observed. The total variation amplitude tended to decrease with decreasing frequency. Strong ...

Opacity and noninear effects on theoretical BL Herculis models

International Nuclear Information System (INIS)

Hodson, S.W.; Cox, A.N.; King, D.S.

1982-01-01

Linear and nonlinear pulsation models for BL Herculis variables have been constructed to investigate the resonance which seems to occur when the ratio of the second overtone (Pi 2 ) to fundamental (Pi 0 ) radial periods is near 0.5. This resonance is shown to affect the shapes of the light and velocity curves and produce bumps on either ascending or descending light just as far classical Cepheids. Linear theory predicts the resonance to occur at periods between 1.7 and 3.0 days for 0.55 M/sub sun/ and between 2.1 and 4.0 days for 0.75 M/sub sun/ stars at the red and blue edges, respectively, of the stability strip. These periods are rather independent of the composition and opacity tables. However, observations show the resonance to be about 1.7 days for all BL Her variables by noticing that the bump phase switches from descending to ascending light as the period increases. Nonlinear calculations indicate that the linear theory predictions of Pi 2 /Pi 0 are not reliable just at Pi 2 /Pi 0 = 0.5, and the predicted resonance occurs always at the proper period as observed

Arnold Rüütel ja Toomas Hendrik Ilves raamaturiiulil

Index Scriptorium Estoniae

2006-01-01

Arnold Rüütel. Tuleviku taassünd. Tallinn : Ilo, 2001; Toomas Kall. Rüütel : rahva keeles ja meeles. Tallinn : Varrak, 2006; Eesti Vabariigi President Arnold Rüütel. [Tallinn] : Ilo, 2006; Arnold Rüütel. Agraar-tööstuskompleksi areng Eesti NSV-s. Tallinn : Valgus, 1982; Arnold Rüütel. President : [valik Vabariigi Presidendi Arnold Rüütli kõnedest]. Tallinn : Eesti Keele Sihtasutus, 2003; Toomas Hendrik Ilves. Eesti jõudmine. Tallinn : Varrak, 2006

Short outlines of books by Estonian authors / Janika Kronberg and Rutt Hinrikus

Index Scriptorium Estoniae

Kronberg, Janika, 1963-

2010-01-01

Arvustus: Käsper, Kalle. Buridanid. I-V. Tallinn : Eesti Keele Sihtasutus, 2005-2010 ; Kivastik, Mart. Eesti asjad. Tartu : Kaks Musketäri, 2010 ; Kangro, Maarja. Ahvid ja solidaarsus. Tallinn : Eesti keele Sihtasutus, 2010 ; Põder, Rein. Unustatud. Tallinn : Eesti Raamat, 2010 ; Kesküla, Kalev. Elu sumedusest. Tallinn : Tuum, 2009 ; Pilv, Aare. Ramadaan. Tallinn : Tuum, 2010

The REX survey as a tool to test the beaming model for BL Lacs

CERN Document Server

Caccianiga, A; MacCacaro, T; Wolter, A; Gioia, I M

1999-01-01

In the context of the beaming model (BM) BL Lac and FR I radio galaxies are thought to be the same class of sources seen at different angles. If this picture is correct, we expect to find some transition objects with intermediate properties between the two classes. To date, this intermediate population of objects is missing, probably due to the limiting fluxes of the current X-ray/radio surveys and/or to the criteria used to separate BL Lacs from normal elliptical galaxies. As pointed out by Browne and Marcha (1993), the detection of the transition objects requires particular attention since the "weak" BL Lac nucleus is hidden by the light of the host elliptical galaxy. A useful criterion often used to assess the presence of a non-thermal source, in addition to the stellar emission of the host galaxy, is the Ca contrast at 4000 AA (K/sub 4000/). This quantity, which is defined as the relative depression of the spectrum across 4000 AA, is a typical feature observed in a "normal" elliptical galaxy; the samples ...

Mida loed sina? / Indrek Hargla

Index Scriptorium Estoniae

Hargla, Indrek, pseud., 1970-

2007-01-01

Tutvustus: Pérez-Reverte, Arturo. Dumas̀ klubi ehk Richelieu vari. Tallinn : Varrak, 2006 ; Belials, Veiko. Jumalate vandenõu. Tallinn : Varrak, 2006 ; Põder, Rein. Eike. Tallinn : Eesti Raamat, 2006 ; Reeve, Philip. Kuldseeklid. Tallinn : Tiritamm, 2006 ; Martin, George R. R. Troonide mäng. Esimene raamat / tlk. Mario Kivistik. Tallinn : Varrak, 2006. (Jää ja tule laul) (F-sari)

Long-Term Optical Spectra Variability of BL Lacertae Object S5 ...

Indian Academy of Sciences (India)

—methods: periodogram analysis method, wavelet analysis method. 1. Introduction. S5 0716+714 is a typical BL Lac object, and it is very striking due to its observational properties. Heidt & Wagner (1996) found a period of 4 days through flux ...

Short outlines of books by Estonian authors / Leena Kurvet-Käosaar, Brita Melts, Rutt Hinrikus and Janika Kronberg

Index Scriptorium Estoniae

2011-01-01

Arvustus: Nurklik, Siim. Kas ma olen nüüd elus. Tallinn : S. Nurklik, 2010 ; Lintrop, Aado. Annapurna. Tartu : Ilmamaa, 2010 ; Lintrop, Aado. Õhtud sõidavad õue. Tartu : Ilmamaa, 2011 ; Saar, Anti. Tekste siledast ruumist. Tallinn : Eesti Keele Sihtasutus, 2009 ; Hvostov, Andrei. Sillamäe passioon. Tartu : Petrone Print, 2011 ; Nõu, Helga. Valetaja. Tallinn : Eesti Ajalehed, 2011 ; Malin, Jaan. Alati vahe. Tallinn : Tuum, 2010 ; Jõerüüt, Jaak. Muutlik. Tallinn : Tuum, 2010 ; Luik, Viivi. Varjuteater. Tallinn : Eesti Keele Sihtasutus, 2010

Short outlines of books by Estonian authors / Brita Melts, Rutt Hinrikus and Janika Kronberg

Index Scriptorium Estoniae

Melts, Brita

2012-01-01

Arvustus: Kilusk, Ott. Veidrikud ja võpatused. Tallinn : Menu, 2012 ; Kilusk, Ott. Oktoobrikuine tuuker. Tallinn : Kirjastuskeskus, 2010 ; Hansen, Aime. Ma olin mereingel. Tallinn : Verb, 2011 ; Vallisoo, Mari. Koidutäht koolivihikus. Tartu : Ilmamaa, 2011 ; Sinijärv, Karl Martin. Krümitor 0671. Tallinn ; Näo Kirik, 2011 ; Aareleid, Kai. Vene veri. Tallinn : Varrak, 2011 ; Ashilevi, Jim. Ma olen elus olemise tunne. Luige : Verb, 2011 ; Traat, Mats. Vastsed Harala elulood. Tartu : Ilmamaa, 2011 ; Tamm, Margus. Unesnõiduja. Tallinn : Raudwara, 2011

Iterative solution of multiple radiation and scattering problems in structural acoustics using the BL-QMR algorithm

Energy Technology Data Exchange (ETDEWEB)

Malhotra, M. [Stanford Univ., CA (United States)

1996-12-31

Finite-element discretizations of time-harmonic acoustic wave problems in exterior domains result in large sparse systems of linear equations with complex symmetric coefficient matrices. In many situations, these matrix problems need to be solved repeatedly for different right-hand sides, but with the same coefficient matrix. For instance, multiple right-hand sides arise in radiation problems due to multiple load cases, and also in scattering problems when multiple angles of incidence of an incoming plane wave need to be considered. In this talk, we discuss the iterative solution of multiple linear systems arising in radiation and scattering problems in structural acoustics by means of a complex symmetric variant of the BL-QMR method. First, we summarize the governing partial differential equations for time-harmonic structural acoustics, the finite-element discretization of these equations, and the resulting complex symmetric matrix problem. Next, we sketch the special version of BL-QMR method that exploits complex symmetry, and we describe the preconditioners we have used in conjunction with BL-QMR. Finally, we report some typical results of our extensive numerical tests to illustrate the typical convergence behavior of BL-QMR method for multiple radiation and scattering problems in structural acoustics, to identify appropriate preconditioners for these problems, and to demonstrate the importance of deflation in block Krylov-subspace methods. Our numerical results show that the multiple systems arising in structural acoustics can be solved very efficiently with the preconditioned BL-QMR method. In fact, for multiple systems with up to 40 and more different right-hand sides we get consistent and significant speed-ups over solving the systems individually.

Cat odor exposure induces distinct changes in the exploratory behavior and Wfs1 gene expression in C57Bl/6 and 129Sv mice.

Science.gov (United States)

Raud, Sirli; Sütt, Silva; Plaas, Mario; Luuk, Hendrik; Innos, Jürgen; Philips, Mari-Anne; Kõks, Sulev; Vasar, Eero

2007-10-16

129Sv and C57Bl/6 (Bl6) strains are two most widely used inbred mice strains for generation of transgenic animals. The present study confirms the existence of substantial differences in the behavior of these two mice strains. The exploratory behavior of Bl6 mice in a novel environment was significantly higher compared to 129Sv mice. The exposure of mice to cat odor-induced an anxiety-like state in Bl6, but not in 129Sv mice. The levels of Wfs1 gene expression did not differ in the prefrontal cortex, mesolimbic area and temporal lobe of experimentally naive Bl6 and 129Sv mice. However, after cat odor exposure the expression of Wfs1 gene was significantly lower in the mesolimbic area and temporal lobe of Bl6 mice compared to 129Sv strain. Dynamics of Wfs1 gene expression and exploratory behavior suggest that the down-regulation of Wfs1 gene in Bl6 mice might be related to the increased anxiety. Further studies are needed to test the robustness and possible causal relationship of this finding.

Short outlines of books by Estonian authors / Janika Kronberg, Rutt Hinrikus

Index Scriptorium Estoniae

Kronberg, Janika, 1963-

2003-01-01

Sinijärv, Karl- Martin. Artutart & 39. Tallinn : Tuum, 2002 ; Beier, Priidu. Monaco. Tartu : P. Beier, 2002 ; Malin, Jaan. Sulle. Tartu : J. Malin, 2003 ; Liiv, Toomas. Luuletused 1968-2002. Tallinn : Tuum, 2003 ; Mägi, Arvo. Katk ja koolera. Tartu : Ilmamaa ; Kross, Jaan. Omaeluloolisus ja alltekst. Tallinn : Eesti Keele Sihtasutus, 2003 ; Kaplinski, Jaan ; Salminen, Johannes. Ööd valged ja mustad. Tallinn : Loomingu Raamatukogu, 2003 ; Kauksi Ülle. Käänüpäiv. Tartu : Kauksi Ülle Mänedsment', 2003 ; Luik, Tõnu. Filosoofiast kõnelda. Tartu : Ilmamaa, 2002 ; Teder, Tarmo. Pööningujutud. Tallinn : Eesti Keele Sihtasutus, 2002 ; Vetemaa, Enn. Minu väga magus elu ehk martsipanimeister. Tallinn : Tänapäev, 2002 ; Põldroos, Enn. Joonik kivi. Tallinn : Eesti Keele Sihtasutus, 2003 ; Suburg, Lilli. Kogutud kirjatööd. Tallinn : Eesti Raamat, 2002 ; Mikelsaar, Henn. Müüritud. Tartu : Ilmamaa, 2003 ; Kaus, Jan. Õndsate tund. Tallinn : Tuum, c2003

Spontaneous autoimmunity in 129 and C57BL/6 mice-implications for autoimmunity described in gene-targeted mice.

Directory of Open Access Journals (Sweden)

Anne E Bygrave

2004-08-01

Full Text Available Systemic lupus erythematosus (SLE is a multisystem autoimmune disorder in which complex genetic factors play an important role. Several strains of gene-targeted mice have been reported to develop SLE, implicating the null genes in the causation of disease. However, hybrid strains between 129 and C57BL/6 mice, widely used in the generation of gene-targeted mice, develop spontaneous autoimmunity. Furthermore, the genetic background markedly influences the autoimmune phenotype of SLE in gene-targeted mice. This suggests an important role in the expression of autoimmunity of as-yet-uncharacterised background genes originating from these parental mouse strains. Using genome-wide linkage analysis, we identified several susceptibility loci, derived from 129 and C57BL/6 mice, mapped in the lupus-prone hybrid (129 x C57BL/6 model. By creating a C57BL/6 congenic strain carrying a 129-derived Chromosome 1 segment, we found that this 129 interval was sufficient to mediate the loss of tolerance to nuclear antigens, which had previously been attributed to a disrupted gene. These results demonstrate important epistatic modifiers of autoimmunity in 129 and C57BL/6 mouse strains, widely used in gene targeting. These background gene influences may account for some, or even all, of the autoimmune traits described in some gene-targeted models of SLE.

The Sedentary Multi-Frequency Survey. I. Statistical Identification and Cosmological Properties of HBL BL Lacs

OpenAIRE

Giommi, P.; Menna, M. T.; Padovani, P.

1999-01-01

We have assembled a multi-frequency database by cross-correlating the NVSS catalog of radio sources with the RASSBSC list of soft X-ray sources, obtaining optical magnitude estimates from the Palomar and UK Schmidt surveys as provided by the APM and COSMOS on-line services. By exploiting the nearly unique broad-band properties of High-Energy Peaked (HBL) BL Lacs we have statistically identified a sample of 218 objects that is expected to include about 85% of BL Lacs and that is therefore seve...

Anomalous energy exchange in the gBL and quasilinear theories

International Nuclear Information System (INIS)

Mynick, H.E.

1992-02-01

The rate of turbulence-induced energy exchange W o between species is computed in the framework of the quasilinear and gBL transport theories, and the relationship between these two theories, and the relationship between these two similar theories is thereby elucidated. For both theories, general formal expressions for W o are developed, and then applied to the trapped electron mode for illustration. The general expressions for W o in the two theories are formally closely related, but can yield predictions of very different magnitude in concrete applications. The fact that quasilinear theory is not valid for saturated steady-state turbulence gives rise to certain peculiarities in its predictions for this normal experimental situation, such as permitting energy to flow from the cooler to the hotter species, even in the limit of thermal equilibrium, where real-space gradients vanish. The gBL theory may be viewed as a modification of quasilinear theory to be valid for steady-state turbulence, keeping extra terms due to the self-consistent back reaction of particles on the fluctuations, which are just such as to eliminate these peculiarities

Book reviews / by Jürgen Rooste and Paul Raud

Index Scriptorium Estoniae

Rooste, Jürgen, 1979-

2016-01-01

Arvustus: Sinijärv, Karl Martin. KMSX: kuidas öelda. Tallinn Näo Kirik, 2016 ; Heinsaar, Mehis. Unistuste tappev kasvamine. Tallinn : Menu, 2016 ; Friedenthal, Meelis. Inglite keel. Tallinn : Varrak, 2016 ; Filimonov, P. I. Laulis, kuni kõik lõppes / tõlkinud Ingrid Velbaum-Staub. Tallinn : Varrak, 2016 ; Urgas, Silvia. Siht/Koht. Tartu : Elusamus, 2015 ; Kaus, Jan. Läheduste raamat. Tallinn : Verb, 2016

Numerical study of Tallinn storm-water system flooding conditions using CFD simulations of multi-phase flow in a large-scale inverted siphon

Science.gov (United States)

Kaur, K.; Laanearu, J.; Annus, I.

2017-10-01

The numerical experiments are carried out for qualitative and quantitative interpretation of a multi-phase flow processes associated with malfunctioning of the Tallinn storm-water system during rain storms. The investigations are focused on the single-line inverted siphon, which is used as under-road connection of pipes of the storm-water system under interest. A multi-phase flow solver of Computational Fluid Dynamics software OpenFOAM is used for simulating the three-phase flow dynamics in the hydraulic system. The CFD simulations are performed with different inflow rates under same initial conditions. The computational results are compared essentially in two cases 1) design flow rate and 2) larger flow rate, for emptying the initially filled inverted siphon from a slurry-fluid. The larger flow-rate situations are under particular interest to detected possible flooding. In this regard, it is anticipated that the CFD solutions provide an important insight to functioning of inverted siphon under a restricted water-flow conditions at simultaneous presence of air and slurry-fluid.

Kolm kogumikku Eesti ajaloolisi linnaplaane / Heino Mardiste

Index Scriptorium Estoniae

Mardiste, Heino, 1936-

2016-01-01

Tutvustus: Eesti linnade plaanid 1584-2011 [Kaart] / koostaja Tõnu Raid. Tallinn : Grenader, 2013 ; Tartu ajaloolistel linnaplaanidel 1600-2010 [Kaart] / koostaja Tõnu Raid. Tallinn : Grenader, 2015 ; Tallinn ajaloolistel linnaplaanidel 1634-1989 [Kaart] / koostaja Tõnu Raid. Tallinn : Grenader, 2011

Immunobiologic effects of cytokine gene transfer of the B16-BL6 melanoma.

Science.gov (United States)

Strome, S E; Krauss, J C; Cameron, M J; Forslund, K; Shu, S; Chang, A E

1993-12-01

The genetic modification of tumors offers an approach to modulate the host immune response to relatively weak native tumor antigens. We examined the immunobiologic effects of various cytokine genes transferred into the poorly immunogenic B16-BL6 murine melanoma. Retroviral expression vectors containing cDNAs for interleukin 2, interleukin 4, interferon gamma, or a neomycin-resistant control were electroporated into a B16-BL6 tumor clone. Selected transfected clones were examined for in vitro cytokine secretion and in vivo tumorigenicity. When cells from individual clones were injected intradermally into syngeneic mice, the interleukin 4-secreting clone grew significantly slower than did the neomycin-resistant transfected control, while the growth of the interleukin 2- and interferon gamma-expressing clones was not affected. Despite minimal cytokine secretion by interferon gamma-transfected cells, these cells expressed upregulated major histocompatibility class I antigen and were more susceptible to lysis by allosensitized cytotoxic T lymphocytes compared with parental or neomycin-resistant transfected tumor targets. We observed diverse immunobiologic effects associated with cytokine gene transfer into the B16-BL6 melanoma. Interleukin 4 transfection of tumor resulted in decreased in vivo tumorigenicity that may be related to a host immune response. Further studies to evaluate the host T-cell response to these gene-modified tumors are being investigated.

Pengaruh Pembelajaran Project Based Learning (PjBL pada Materi Ekosistem terhadap Sikap dan Hasil Belajar Siswa SMAN 2 Malang

Directory of Open Access Journals (Sweden)

Susriyati Mahanal

2010-05-01

Full Text Available The objective of this research was to know the effect of Project Based Learning (PjBL to the attitude and student cognitive achievement in SMAN 2 Malang. This research applied quasy experimental with non-equivalent control group design. The populations of this research is all student of class X SMAN 2 Malang on academic year 2008/2009. The samples of this research were class X7 as experimental (PjBL and class X8 as control (conventional. The instrument of this research namely cognitive achievement test and attitude scale questionnaire to river ecosystem. This research data are quantitative data consisted by score cognitive achievement and attitude scale questionnaire to river ecosystem, collected on 14 Maret until 31 May 2009. Data were analysed by bilinear covariant statistical analysis (Ancova, continued with LSD test. The result of this research indicated that there were PjBL toward the cognitive achievement and student attitude to river ecosystem. Students with PjBl having attitude higher 11,65% from conventional students. Beside, students with PjBl having cognitive achievement higher 81,05% from conventional students. Based on this research, the researcher suggest to the teacher that this strategy can be implemented in biology learning.   Kata kunci: Project Based Learning, sikap terhadap ekosistem sungai, hasil belajar

Bl-1020, a new γ-aminobutyric acid-enhanced antipsychotic: results of 6-week, randomized, double-blind, controlled, efficacy and safety study.

Science.gov (United States)

Geffen, Yona; Keefe, Richard; Rabinowitz, Jonathan; Anand, Ravi; Davidson, Michael

2012-09-01

BL-1020 is a γ-aminobutyric acid (GABA)-enhanced antipsychotic that combines dopamine antagonism with GABA agonist activity. On the basis of animal models, we tested the hypotheses that BL-1020 would be effective in ameliorating both psychotic symptoms and cognitive impairments, with a favorable safety profile in acutely ill schizophrenia patients. 363 hospital-based psychiatric patients in India, Romania, and United States aged 18 to 65 years and meeting criteria for DSM-IV-TR diagnosis of chronic schizophrenia were randomized double-blind to receive BL-1020 10 mg/d, BL-1020 20-30 mg/d, placebo, or risperidone (2-8 mg/d) for 6 weeks. The main outcome measures were the positive and negative syndrome scale (PANSS), brief assessment of cognition in schizophrenia, readiness for discharge questionnaire, clinical global impressions scale (CGI) , and extrapyramidal symptom rating scale. The study ran from July 2008 to June 2009. BL-1020 20-30 mg was significantly better than placebo on PANSS (P = .02) and CGI (P schizophrenia composite score when compared to placebo (effect size = 0.50, P = .009), risperidone (effect size = 0.43, P = .019), and BL-1020 10 mg (effect size = 0.42, P = .013) after 6 weeks. BL-1020 appears to be an effective antipsychotic with possible procognitive effects that will need to be further tested for short- and long-term effects. A further randomized controlled trial using the U.S. Food and Drug Administration-recommended Measurement and Treatment Research to Improve Cognition in Schizophrenia cognitive battery is ongoing. ClinicalTrials.gov identifier: NCT00567710. © Copyright 2012 Physicians Postgraduate Press, Inc.

Short outlines of books by Estonian authors / Janika Kronberg, Rutt Hinrikus

Index Scriptorium Estoniae

Kronberg, Janika, 1963-

2005-01-01

Tutvustus: Henno, Sass. Mina olin siin. 1 : esimene arest. Tallinn : Eesti Päevaleht, 2005 ; Kruusvall, Jaan. Sinetavad kaugused : valitud proosat. Tallinn : Eesti Raamat, 2004 ; Hirv, Indrek. Klaaskübara all : [esseed]. Tartu : Ilmamaa, 2004 ; Õudne Eesti : valimik eesti õudusjutte. Tallinn : Varrak, 2005 ; Ruitlane, Olavi. Kroonu. Räpina : Väiku Välläandja, 2005 ; Ehin, Kristiina. Kaitseala. Tallinn : Huma, 2005 ; Kivirähk, Andrus. Jutud. Tallinn : Eesti Kirjanduse Sihtasutus, 2005 ; Talvet, Jüri. Unest, lumest. Tartu : Ilmamaa, 2005 ; Künnap, Asko. Kõige ilusam sõda. Tallinn : Näo Kirik, 2004 ; Kaplinski, Jaan. Kaks päikest : teistmoodi muinaslood. Tallinn : Tänapäev, 2005 ; Alver, Betti. Koguja : suur luuleraamat. Tartu : Ilmamaa, 2005

A high-fat diet delays age-related hearing loss progression in C57BL/6J mice.

Directory of Open Access Journals (Sweden)

Takeshi Fujita

Full Text Available Age-related hearing loss (AHL, or presbycusis, is the most common sensory disorder among the elderly. We used C57BL/6J mice as an AHL model to determine a possible association between AHL and a high-fat diet (HFD.Forty C57BL/6J mice were randomly assigned to a control or HFD group. Each group was divided into the following subgroups: 1-, 3-, 5- and 12-month groups (HFD, n = 5/subgroup; control, n = 5/subgroup. Nine CBA/N-slc mice were also used as a 12-month control (n = 5 or 12-month HFD (n = 4 group. The mice were fed a HFD or normal (control diet throughout this study. Hearing function was evaluated at 1, 3, 5 and 12 months using auditory evoked brainstem responses (ABRs. Spiral ganglion cells (SGCs were also counted.The elevation of ABR thresholds (at 4 and 32 kHz at 3 and 5 months was significantly suppressed in the HFD group compared with the control groups for C57BL/6J mice. After 12 months, the elevation of ABR thresholds was significantly suppressed in the HFD group at all frequencies for C57BL/6J mice. In contrast, CBA/N-slc mice displayed opposite outcomes, as ABR thresholds at all frequencies at 12 months were significantly elevated in the HFD group compared with the control group. For the C57BL/6J mice at 12 months, SGC numbers significantly decreased in all parts of the cochleae in the control group compared with the HFD groups. In contrast, for the CBA/N-slc mice, SGC numbers significantly decreased, particularly in the upper parts of the cochleae in the HFD group compared with the control groups.The elevation in ABR thresholds and SGC loss associated with aging in the HFD-fed C57BL/6J mice were significantly suppressed compared with those in the normal diet-fed mice. These results suggest that HFD delays AHL progression in the C57B/6J mice.

A High-Fat Diet Delays Age-Related Hearing Loss Progression in C57BL/6J Mice

Science.gov (United States)

Fujita, Takeshi; Yamashita, Daisuke; Uehara, Natsumi; Inokuchi, Go; Hasegawa, Shingo; Otsuki, Naoki; Nibu, Ken-ichi

2015-01-01

Objective Age-related hearing loss (AHL), or presbycusis, is the most common sensory disorder among the elderly. We used C57BL/6J mice as an AHL model to determine a possible association between AHL and a high-fat diet (HFD). Methods Forty C57BL/6J mice were randomly assigned to a control or HFD group. Each group was divided into the following subgroups: 1-, 3-, 5- and 12-month groups (HFD, n = 5/subgroup; control, n = 5/subgroup). Nine CBA/N-slc mice were also used as a 12-month control (n = 5) or 12-month HFD (n = 4) group. The mice were fed a HFD or normal (control) diet throughout this study. Hearing function was evaluated at 1, 3, 5 and 12 months using auditory evoked brainstem responses (ABRs). Spiral ganglion cells (SGCs) were also counted. Results The elevation of ABR thresholds (at 4 and 32 kHz) at 3 and 5 months was significantly suppressed in the HFD group compared with the control groups for C57BL/6J mice. After 12 months, the elevation of ABR thresholds was significantly suppressed in the HFD group at all frequencies for C57BL/6J mice. In contrast, CBA/N-slc mice displayed opposite outcomes, as ABR thresholds at all frequencies at 12 months were significantly elevated in the HFD group compared with the control group. For the C57BL/6J mice at 12 months, SGC numbers significantly decreased in all parts of the cochleae in the control group compared with the HFD groups. In contrast, for the CBA/N-slc mice, SGC numbers significantly decreased, particularly in the upper parts of the cochleae in the HFD group compared with the control groups. Conclusions The elevation in ABR thresholds and SGC loss associated with aging in the HFD-fed C57BL/6J mice were significantly suppressed compared with those in the normal diet-fed mice. These results suggest that HFD delays AHL progression in the C57B/6J mice. PMID:25625852

Short outlines of books by Estonian authors / Brita Melts, Rutt Hinrikus and Janika Kronberg

Index Scriptorium Estoniae

Melts, Brita

2015-01-01

Arvustus: Viitol, Livia. Jutte ja novelle. Tallinn : Libri Livoniae, 2014 ; Talvet, Jüri. Ten Letters to Montaigne : "Self" and "other". Tartu : Tartu Ülikooli Kirjastus, 2014 ; Rooste, Jürgen. Suur sume, suur tume. [Luige (Kiili vald)] : Verb, 2014 ; Kross, Märten. Hullumäng. [Tallinn] : Tammerraamat, 2014 ; Kaus, Jan. Ma olen elus. Tallinn : Tuum, 2014 ; Kangro, Maarja. Hüppa tulle. Tallinn : Nähtamatu Ahv, 2014 ; Kasemaa, Andrus. Minu viimane raamat. Tallinn : Varrak, 2014 ; Raik, Katri. Minu Narva : kahe maailma vahel. [Tartu] : Petrone Print, 2013 ; Kareva, Doris. Maailma asemel. [Kordustr. Tallinn] : Verb, 2014

Nobelistid : süütuse rebestus ja üllatus / Vaapo Vaher

Index Scriptorium Estoniae

Vaher, Vaapo, 1945-

2008-01-01

Tutvustatakse 2008. a. eesti keeles ilmunud Nobeli kirjandusauhinna laureaatide jt. teoseid: Faulkner, William. Absalom, Absalom! / tlk. Kersti Unt. Tallinn : Tänapäev, 2008 ; Dostojevski, Fjodor. Alandatud ja solvatud / tlk. Leopold Kenn. Tallinn : Eesti Raamat, 2008 ; Böll, Heinrich. Ametisõidu lõpp / tlk. Mati Sirkel. Tallinn : Varrak, 2008 ; Morrison, Toni. Dzhäss / tlk. Udo Uibo ja Krista Kaer. Tallinn : Varrak, 2008 ; Laxness, Halld̤r. Islandi kell / tlk. Arvo Alas ja Askur Alas. Tallinn : Varrak, 2008 ; Bunin, Ivan. Armastuse grammatika : [novellid] / koost. Rein Põder ; tlk. Jüri Pärni. Tallinn : Eesti Raamat, 2008

Closure Report for Corrective Action Unit 110: Areas 3 RWMS U-3ax/bl Disposal Unit, Nevada Test Site, Nevada

Energy Technology Data Exchange (ETDEWEB)

J. L. Smith

2001-08-01

This Closure Report (CR) has been prepared for the Area 3 Radioactive Waste Management Site (RWMS) U-3ax/bl Disposal Unit Corrective Action Unit (CAU) 110 in accordance with the reissued (November 2000) Resource Conservation and Recovery Act (RCRA) Part B operational permit NEV HW009 (Nevada Division of Environmental Protection [NDEP], 2000) and the Federal Facility and Consent Order (FFACO) (NDEP et al., 1996). CAU 110 consists of one Corrective Action Site 03-23-04, described as the U-3ax/bl Subsidence Crater. Certifications of closure are located in Appendix A. The U-3ax/bl is a historic disposal unit within the Area 3 RWMS located on the Nevada Test Site (NTS). The unit, which was formed by excavating the area between two subsidence craters (U-3ax and U-3bl), was operationally closed in 1987. The U-3ax/bl disposal unit was closed under the RCRA, as a hazardous waste landfill. Existing records indicate that, from July 1968 to December 1987, U-3ax/bl received 2.3 x 10{sup 5} cubic meters (m{sup 3}) (8.12 x 10{sup 6} cubic feet [ft{sup 3}]) of waste. NTS atmospheric nuclear device testing generated approximately 95% of the total waste volume disposed of in U-3ax/bl; 80% of the total volume was generated from the Waste Consolidation Project. Area 3 is located in Yucca Flat, within the northeast quadrant of the NTS. The Yucca Flat watershed is a structurally closed basin encompassing an area of approximately 780 square kilometers (300 square miles). The structural geomorphology of Yucca Flat is typical of the Basin and Range Physiographic Province. Yucca Flat lies in one of the most arid regions of the country. Water balance calculations for Area 3 indicate that it is normally in a state of moisture deficit.

Antimetastatic effect of PSK, a protein-bound polysaccharide, against the B16-BL6 mouse melanoma.

Science.gov (United States)

Matsunaga, K; Ohhara, M; Oguchi, Y; Iijima, H; Kobayashi, H

1996-01-01

We examined the effect of PSK, a protein-bound polysaccharide, upon in vivo metastasis and in vitro invasion of the B16-BL6 mouse melanoma cells. (1) PSK suppressed in vivo artificial and spontaneous lung metastases of B16-BL6 in C57BL/6 mice. (2) PSK in a dose-dependent fashion suppressed in vitro invasion and chemotaxis of the tumor cells using filters coated with a reconstituted basement membrane. (3) PSK had little effect on DNA synthesis in tumor cells in vitro, but suppressed tumor cell adhesion to, degradation of, and haptotaxis to components of the basement membrane. (4) PSK suppressed the binding of tumor cells to components of the basement membrane. These findings suggest that PSK may suppress metastasis through inhibition of tumor cell invasion and that this effect is the result of interactions between PSK and components of the basement membrane.

Computing Optical Variable Periods of BL Lac Object S5 0716+ 714 ...

Indian Academy of Sciences (India)

Computing Optical Variable Periods of BL Lac Object S5 0716+ 714 ... The study of long-term periodical variation is an important way to get the charac- ... continuous Fourier transform together, define a window function, and finally obtain.

Journey towards yourself / Rein Veidemann

Index Scriptorium Estoniae

Veidemann, Rein, 1946-

2011-01-01

Arvustus: Luik, Viivi. Varjuteater. Tallinn : Eesti Keele Sihtasutus, 2010 ; Luik, Viivi, Rosma, Hedi. Ma olen raamat. Tallinn : SE & JS, 2010 ; Jõerüüt, Jaak. Armastuse laiad, kõrged hooned. Tallinn : Tuum, 2010 ; Jõerüüt, Jaak. Muutlik. Tallinn : Tuum, 2010

Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection.

Science.gov (United States)

Takahashi, Yuki; Nishikawa, Makiya; Shinotsuka, Haruka; Matsui, Yuriko; Ohara, Saori; Imai, Takafumi; Takakura, Yoshinobu

2013-05-20

The development of exosomes as delivery vehicles requires understanding how and where exogenously administered exosomes are distributed in vivo. In the present study, we designed a fusion protein consisting of Gaussia luciferase and a truncated lactadherin, gLuc-lactadherin, and constructed a plasmid expressing the fusion protein. B16-BL6 murine melanoma cells were transfected with the plasmid, and exosomes released from the cells were collected by ultracentrifugation. Strong luciferase activity was detected in the fraction containing exosomes, indicating their efficient labeling with gLuc-lactadherin. Then, the labeled B16-BL6 exosomes were intravenously injected into mice, and their tissue distribution was evaluated. Pharmacokinetic analysis of the exosome blood concentration-time profile revealed that B16-BL6 exosomes disappeared very quickly from the blood circulation with a half-life of approximately 2min. Little luciferase activity was detected in the serum at 4h after exosome injection, suggesting rapid clearance of B16-BL6 exosomes in vivo. Moreover, sequential in vivo imaging revealed that the B16-BL6 exosome-derived signals distributed first to the liver and then to the lungs. These results indicate that gLuc-lactadherin labeling is useful for tracing exosomes in vivo and that B16-BL6 exosomes are rapidly cleared from the blood circulation after systemic administration. Copyright © 2013 Elsevier B.V. All rights reserved.

Affinity labelling in situ of the bL12 protein on E. coli 70S ribosomes by means of a tRNA dialdehyde derivative.

Science.gov (United States)

Hountondji, Codjo; Créchet, Jean-Bernard; Le Caër, Jean-Pierre; Lancelot, Véronique; Cognet, Jean A H; Baouz, Soria

2017-12-01

In this report, we have used periodate-oxidized tRNA (tRNAox) as an affinity laleling reagent to demonstrate that: (i) the bL12 protein contacts the CCA-arm of P-site bound tRNA on the Escherichia coli 70S ribosomes; (ii) the stoichiometry of labelling is one molecule of tRNAox bound to one polypeptide chain of endogenous bL12; (iii) cross-linking in situ of bL12 with tRNAox on the ribosomes provokes the loss of activity; (iv) intact tRNA protects bL12 in the 70S ribosomes against cross-linking with tRNAox; (v) both tRNAox and pyridoxal 5'-phosphate (PLP) compete for the same or for proximal cross-linking site(s) on bL12 inside the ribosome; (vi) the stoichiometry of cross-linking of PLP to the recombinant E. coli bL12 protein is one molecule of PLP covalently bound per polypeptide chain; (vii) the amino acid residue of recombinant bL12 cross-linked with PLP is Lys-65; (viii) Lys-65 of E. coli bL12 corresponds to Lys-53 of eL42 which was previously shown to cross-link with P-site bound tRNAox on human 80S ribosomes in situ; (ix) finally, E. coli bL12 and human eL42 proteins display significant primary structure similarities, which argues for evolutionary conservation of these two proteins located at the tRNA-CCA binding site on eubacterial and eukaryal ribosomes. © The Authors 2017. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved.

Infrared polarimetry and photometry of BL Lac objects. 2

Energy Technology Data Exchange (ETDEWEB)

Impey, C D [Hawaii Univ., Honolulu (USA). Inst. for Astronomy; Brand, P W.J.L. [Edinburgh Univ. (UK). Dept. of Astronomy; Wolstencroft, R D [Royal Observatory, Edinburgh (UK); Williams, P M [United Kingdom Infrared Telescope Unit, Hilo, Hawaii (USA)

1984-07-15

Photometry and polarimetry in the JHK wavebands have now been obtained for 25 BL Lac objects. Several new objects have been monitored for periods of up to five days, and accumulated data is sufficient for a statistical analysis of polarization properties. The selection effects operating on this sample are examined first. A power-law spectrum is consistent with the spectra of all but three objects. A number of important new results are reported.

Induction of cell-mediated immunity against B16-BL6 melanoma in mice vaccinated with cells modified by hydrostatic pressure and chemical crosslinking.

Science.gov (United States)

Eisenthal, A; Ramakrishna, V; Skornick, Y; Shinitzky, M

1993-05-01

In the preceding paper we have demonstrated an increase in presentation of both major histocompatibility complex antigens (MHC) and a tumor-associated antigen of the weakly immunogenic B16 melanoma by a straight-forward technique. The method consists in modulating the tumor cell membrane by hydrostatic pressure and simultaneous chemical crosslinking of the cell-surface proteins. In B16-BL6 melanoma, the induced antigenic modulation was found to persist for over 48 h, which permitted the evaluation of the ability of modified B16-BL6 cells to induce immunity against unmodified B16-BL6 cells. In the present study, we have shown that a significant systemic immunity was induced only in mice that were immunized with modified B16-BL6 melanoma cells, whereas immunization with unmodified B16-BL6 cells had only a marginal effect when compared to the results in control sham-immunized mice. The induced immunity was specific since a single immunization affected the growth of B16-BL6 tumors but had no effect on MCA 106, an antigenically unrelated tumor. The addition of interleukin-2 to the immunization regimen had no effect on the antitumor responses induced by the modified B16-BL6 cells. The cell-mediated immunity conferred by immunization with treated B16-BL6 cells was confirmed in experiments in vitro where splenocytes from immunized mice could be sensitized to proliferate by the presence of B16-BL6 cells. In addition, the altered antigenicity of these melanoma cells appeared to correlate with their increased susceptibility to specific effectors. Thus, 51Cr-labeled B16-BL6 target cells, modified by pressure and crosslinking, in comparison to control labeled target cells, were lysed in much greater numbers by effectors such as lymphokine-activated killer cells and allogeneic cytotoxic lymphocytes (anti-H-2b), while such cells remained resistant to lysis by natural killer cells. Our findings indicate that the physical and chemical modifications of the tumor cells that are

Neli vaadet tuumale ja näivusele / Märt Väljataga

Index Scriptorium Estoniae

Väljataga, Märt, 1965-

2009-01-01

Arvustus: Tuglas, Friedebert. Valik proosat / koostanud ja saatetekstid kirjutanud Jaan Undusk. Tallinn : Avita, 2009 ; Nietzsche, Friedrich. Tragöödia sünd. Tallinn : Tänapäev, 2009 ; Kesküla, Kalev. Elu sumedusest. Tallinn : Tuum, 2009 ; Sirkel, Mati. Uued orva-aastad. Kommentaarium. Tallinn : Tuum, 2009

Five-day planetary waves in the middle atmosphere from Odin satellite data and ground-based instruments in Northern Hemisphere summer 2003, 2004, 2005 and 2007

Directory of Open Access Journals (Sweden)

A. Belova

2008-11-01

Full Text Available A number of studies have shown that 5-day planetary waves modulate noctilucent clouds and the closely related Polar Mesosphere Summer Echoes (PMSE at the summer mesopause. Summer stratospheric winds should inhibit wave propagation through the stratosphere and, although some numerical models (Geisler and Dickinson, 1976 do show a possibility for upward wave propagation, it has also been suggested that the upward propagation may in practice be confined to the winter hemisphere with horizontal propagation of the wave from the winter to the summer hemisphere at mesosphere heights causing the effects observed at the summer mesopause. It has further been proposed (Garcia et al., 2005 that 5-day planetary waves observed in the summer mesosphere could be excited in-situ by baroclinic instability in the upper mesosphere. In this study, we first extract and analyze 5-day planetary wave characteristics on a global scale in the middle atmosphere (up to 54 km in temperature, and up to 68 km in ozone concentration using measurements by the Odin satellite for selected days during northern hemisphere summer from 2003, 2004, 2005 and 2007. Second, we show that 5-day temperature fluctuations consistent with westward-traveling 5-day waves are present at the summer mesopause, using local ground-based meteor-radar observations. Finally we examine whether any of three possible sources of the detected temperature fluctuations at the summer mesopause can be excluded: upward propagation from the stratosphere in the summer-hemisphere, horizontal propagation from the winter-hemisphere or in-situ excitation as a result of the baroclinic instability. We find that in one case, far from solstice, the baroclinic instability is unlikely to be involved. In one further case, close to solstice, upward propagation in the same hemisphere seems to be ruled out. In all other cases, all or any of the three proposed mechanisms are consistent with the observations.

The influences of age on T lymphocyte subsets in C57BL/6 mice

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Jing Xie

2017-01-01

Full Text Available The aim of this study is to evaluate the age related changes of T lymphocyte subsets in C57BL/6 mice and immune function. Multi-color immunofluorescence techniques that were used to analyse relative numbers of T lymphocyte subsets include CD4+, CD8+, naive and memory CD4+ and CD8+, CD8+CD28+ T cells in peripheral blood of C57BL/6 mice from different age groups (Group I: 2 months old; Group II: 7 months old; Group III: 21 months old; Splenocytes isolated from different group mice were stimulated with Con A to evaluate the proliferative ability. Compared with group I, group II had a significant reduction in the percentage of CD4+, naive CD4+ and CD8+ T cells and an increase in the percentage of CD8+ T cells, while group III had a significant reduction in the percentage of CD4+, naive CD4+ and CD8+ T cells and increase in the percentage of CD8+, memory CD4+ and CD8+ T cells in peripheral blood. Compared with group II, group III had a significant reduction in the percentage of naive CD8+ T cells and increase in the percentage of memory CD4+ and CD8+, CD8+CD28+ T cells in peripheral blood. The T lymphocyte proliferation in vitro showed that groups II and III had a lower proliferative capacity than group I, between groups II and III, there was not a significant difference. We provide relative values for the T lymphocyte subsets in the different age groups of C57BL/6 mice. The immune system began aging at 7 months old in C57BL/6 mice under a specific pathogen free environment.

On the independence of axioms in BL and MTL

Czech Academy of Sciences Publication Activity Database

Chvalovský, Karel

2012-01-01

Roč. 197, 16 June (2012), s. 123-129 ISSN 0165-0114 R&D Projects: GA ČR GEICC/08/E018; GA ČR GD401/09/H007 Grant - others:GA UK(CZ) 73109/2009 Institutional research plan: CEZ:AV0Z10300504 Keywords : non-classical logics * basic fuzzy logic (BL) * monoidal t-norm based logic (MTL) * Hilbert-style calculi * independence of axioms Subject RIV: BA - General Mathematics Impact factor: 1.749, year: 2012

Kerge kohmetus soomeugri veere naisteväe keskel / Lauri Sommer

Index Scriptorium Estoniae

Sommer, Lauri, 1973-

2003-01-01

Arvustus: Neli komilannat / tõlkinud Leelo Tungal ja Arvo Valton. Tallinn : Virgela, 1998 ; Neli marilannat / tõlkinud Leelo Tungal. Tallinn : Virgela, 1998 ; Neli mordvalannat / tõlkinud Peeter Volkonski ja Arvo Valton. Tallinn : Virgela, 1998 ; Neli udmurditari / tõlkinud Ellen Niit, Valeeria Villandi ja Arvo Valton. Tallinn : Virgela, 2002

Äratundmisi soome-ugri naisluulet lugedes / Veronika Kivisilla

Index Scriptorium Estoniae

Kivisilla, Veronika

2003-01-01

Arvustus: Neli komilannat / tõlkinud Leelo Tungal ja Arvo Valton. Tallinn : Virgela, 1998 ; Neli marilannat / tõlkija Leelo Tungal. Tallinn : Virgela, 1998 ; Neli mordvalannat / tõlkinud Peeter Volkonski ja Arvo Valton. Tallinn : Virgela, 1998 ; Neli udmurditari / tõlkinud Ellen Niit, Valeeria Villandi ja Arvo Valton. Tallinn : Virgela, 2002

Kohanenud kirjandus : tänase kirjaniku - ja ka tema lugeja elu sisu määravad majanduslikud argumendid, mitte moraalsed valikud / Kärt Hellerma

Index Scriptorium Estoniae

Hellerma, Kärt, 1956-

2005-01-01

Arvustus: Delerm, Philippe. Väikesed naudingud. Tallinn : Varrak, 2004 ; Nothomb, Amélie. Jumala lapsepõlv. Tallinn : Varrak, 2004 ; Darrieussecq, Marie. Minu beebi. Tallinn : Varrak, 2005. Ilmunud ka kogumikus: Hellerma, Kärt. Kohanenud kirjandus : valik kirjanduskriitikat 1987-2006. Eesti Keele Sihtasutus : Tallinn, 2006. Lk. 189-195, pealk. Kohanenud kirjandus

Kägiseva lindi lood : kassetiaegne unustatud muss / Dr Alimentado

Index Scriptorium Estoniae

Dr Alimentado

2009-01-01

1980-ndate lõpul ja 1990-ndate algul väljaantud helikassettidest: Lost Kolchoses. Kainestusmajas. I.k., i.a. ; B.D.Ö. Anblögged. Tallinn : B.D.Ö., 1993 ; Röövel Ööbik. Ilu. Tallinn : Kuldnokk, 1989 ; Rock the Christmas / Velikije Luki, Röövel Ööbik, Kumikameli ... [jt.]. Tallinn : Kuldnokk, i.a. ; Merry Christmas Mr. Lawrence. Graffity revolution. Tallinn : Kuldnokk, i.a. ; J.M.K.E. Rumal nali. Tallinn : Fucking Cunts Records, 1996

Reis Rosenbergi ajudesse / Vaapo Vaher

Index Scriptorium Estoniae

Vaher, Vaapo, 1945-

2007-01-01

Lugemismuljeid raamatutest: Piper, Ernst. Alfred Rosenberg : Hitleri peaideoloog. Tallinn : Tänapäev, 2007 ; Judt, Tony. Pärast sõda. Euroopa ajalugu 1945. aastast. Tallinn : Varrak, 2007 ; Döblin, Alfred. Berliin, Alexanderplatz / tlk. Mati Sirkel. Tallinn : Tänapäev, 2007 ; Adson, Artur. Siuru-raamat. Tallinn : Tänapäev, 2007

Neetud Siber / Mihkel Mutt

Index Scriptorium Estoniae

Mutt, Mihkel, 1953-

2004-01-01

Rets. rmt.: Brzezinski, Zbigniew. Suur malelaud. Tallinn, 2003 ; Sergejev, Vladimir ; Vseviov, David. Venemaa - lähedane ja kauge. Tallinn, 2002 ; Figes, Orlando. Natasha tants. Venemaa kultuurilugu. Tallinn, 2003 ; Lotman, Juri. Vestlusi vene kultuurist. Vene aadli argielu ja traditsioonid 18. sajandil ja 19. sajandi algul. 1. köide. Tallinn, 2003

Hullud, professorid ja müüdud anne / Vaapo Vaher

Index Scriptorium Estoniae

Vaher, Vaapo, 1945-

2003-01-01

Kurvits, Lembit. Tõrvalill : [luuletused]. Tallinn : Eesti Raamat, 2003 ; Liiv, Toomas. Luuletused 1968-2002. Tallinn : Tuum, 2003 ; Fante, John. Küsi kaduvalt : [romaan / tõlkinud ja järelsõna: Heiti Kender, värsid tõlkinud Mati Soomre. Tallinn] : Hotger, 2003 ; Vinkel, Aarne. Saaremaalt suurele maale. Tallinn : Eesti Keele Sihtasutus, 2003

Project Based Learning (PjBL) Practices at Politeknik Kota Bharu, Malaysia

Science.gov (United States)

Rahman, Md. Baharuddin Haji Abdul; Daud, Khairul Azhar Mat; Jusoff, Kamaruzaman; Ghani, Nik Azida Abd

2009-01-01

This study explores the utilization of Project-based Learning module in the subject of project development for the Mechanical Engineering students at Politeknik Kota Bharu. This study focuses on the development of the PjBL module based on socio-constructivist approach. The objective of this study is to explore the influence of the utilization of…

The new NCPSS BL19U2 beamline at the SSRF for small-angle X-ray scattering from biological macromolecules in solution.

Science.gov (United States)

Li, Na; Li, Xiuhong; Wang, Yuzhu; Liu, Guangfeng; Zhou, Ping; Wu, Hongjin; Hong, Chunxia; Bian, Fenggang; Zhang, Rongguang

2016-10-01

The beamline BL19U2 is located in the Shanghai Synchrotron Radiation Facility (SSRF) and is its first beamline dedicated to biological material small-angle X-ray scattering (BioSAXS). The electrons come from an undulator which can provide high brilliance for the BL19U2 end stations. A double flat silicon crystal (111) monochromator is used in BL19U2, with a tunable monochromatic photon energy ranging from 7 to 15 keV. To meet the rapidly growing demands of crystallographers, biochemists and structural biologists, the BioSAXS beamline allows manual and automatic sample loading/unloading. A Pilatus 1M detector (Dectris) is employed for data collection, characterized by a high dynamic range and a short readout time. The highly automated data processing pipeline SASFLOW was integrated into BL19U2, with help from the BioSAXS group of the European Molecular Biology Laboratory (EMBL, Hamburg), which provides a user-friendly interface for data processing. The BL19U2 beamline was officially opened to users in March 2015. To date, feedback from users has been positive and the number of experimental proposals at BL19U2 is increasing. A description of the new BioSAXS beamline and the setup characteristics is given, together with examples of data obtained.

Protein crystallography beamline (PX-BL21); its utilization and research highlights

International Nuclear Information System (INIS)

Kumar, Ashwani; Ghosh, Biplab; Singh, Rahul; Makde, Ravindra; Sharma, Surinder M.

2016-01-01

The protein crystallography beamline (PX-BL21) is sourced on 1.5 T bending magnet of 2.5 GeV Indus-2 synchrotron. This beamline has been designed to perform monochromatic and anomalous diffraction experiments on single crystals of biological macromolecules such as protein, DNA and their complexes. PX beamline also has a state-of-art ancillary biochemical laboratory to prepare single crystals of biological macromolecules. Since the commissioning of the beamline, it has been utilized by more than 70% of research groups working in the area of protein crystallography in India. About 30 crystal structures of proteins, determined using this beamline, have been deposited in Protein Data Bank (PDB). Some of these structures have been determined using experimental phasing, such as the single wavelength anomalous diffraction (SAD) experiments. The energy tunability of the synchrotron have been exploited to carry our various SAD experiments: Selenium-SAD, Zinc-SAD and Manganese-SAD and Sulphar-SAD. In the present talk, the key results from the PX-BL21 beamline will be discussed. (author)

Kus me kange bestseller? / Peeter Künstler

Index Scriptorium Estoniae

Künstler, Peeter, 1958-2009

2000-01-01

Arvustus: Uustulnd, Lembit. Kiikhobune Antverpenist. Tallinn : Varrak, 1999 ; Tiidenberg, Ants. Vietnam-transiit Tallinn : SE & JS, 1999 ; Tamman, Tiina. Tihe udu Tallinnas. Tallinn : Perioodika, 2000

Cornerstones at the onset of scientific approach in sports training and physical education in Estonia / Atko Viru

Index Scriptorium Estoniae

Viru, Atko-Meeme, 1932-2007

2003-01-01

Kolmest spordiraamatust: Pihkala, Lauri. Poiste spordi õpetus. Tallinn, 1918 ; Kalamees, Aleksander. Algkooli kehakasvatuse käsiraamat. Tallinn, 1936 ; Kask, Mihkel. Sporditervishoid. Tartu ; Tallinn, 1939

Mõned mõtted "suvelugemisest" ja suvelugemisest / Peeter Helme

Index Scriptorium Estoniae

Helme, Peeter, 1978-

2009-01-01

Tutvustatakse ja soovitatakse raamatuid: Aleksejev, Tiit. Palveränd : lugu Esimesest ristisõjast. Tallinn : Varrak, 2008 ; Rebane, Kristi. Minu oma. Tallinn : Tänapäev, 2009 ; Kaints, Holger. Lennukivaatleja. Tallinn : Kultuurileht, 2009 ; Kehlmann, Daniel. Maailma mõõtmine. Tartu : Atlex, c2008 ; Zafón, Carlos Ruiz. Tuule vari. Tallinn : Varrak, 2008

BL-038, a Benzofuran Derivative, Induces Cell Apoptosis in Human Chondrosarcoma Cells through Reactive Oxygen Species/Mitochondrial Dysfunction and the Caspases Dependent Pathway.

Science.gov (United States)

Liu, Ju-Fang; Chen, Chien-Yu; Chen, Hsien-Te; Chang, Chih-Shiang; Tang, Chih-Hsin

2016-09-07

Chondrosarcoma is a highly malignant cartilage-forming bone tumor that has the capacity to invade locally and cause distant metastasis. Moreover, chondrosarcoma is intrinsically resistant to conventional chemotherapy or radiotherapy. The novel benzofuran derivative, BL-038 (2-amino-3-(2,6-dichlorophenyl)-6-(4-methoxyphenyl)benzofuran-4-yl acetate), has been evaluated for its anticancer effects in human chondrosarcoma cells. BL-038 caused cell apoptosis in two human chondrosarcoma cell lines, JJ012 and SW1353, but not in primary chondrocytes. Treatment of chondrosarcoma with BL-038 also induced reactive oxygen species (ROS) production. Furthermore, BL-038 decreased mitochondrial membrane potential (MMP) and changed mitochondrial-related apoptosis, by downregulating the anti-apoptotic activity members (Bcl-2, Bcl-xL) and upregulating pro-apoptotic members (Bax, Bak) of the B-cell lymphoma 2 (Bcl-2) family of proteins, key regulators of the apoptotic machinery in cells. These results demonstrate that in human chondrosarcoma cells, the apoptotic and cytotoxic effects of BL-038 are mediated by the intrinsic mitochondria-mediated apoptotic pathway, which in turn causes the release of cytochrome c, the activation of caspase-9 and caspase-3, and the cleavage of poly (ADP-ribose) polymerase (PARP), to elicit apoptosis response. Our results show that the benzofuran derivative BL-038 induces apoptosis in chondrosarcoma cells.

Effects of phenazepam on the behavior of C57BL/6 and BALB/c mice in the open field test after naloxone pretreatment.

Science.gov (United States)

Seredenin, S B; Nadorova, A V; Kolik, L G; Yarkova, M A

2013-07-01

We studied the effects of phenazepam (0.075 mg/kg) after pretreatment (5 minutes before) with naloxone (10 mg/kg) on open-field behavior of C57Bl/6 and BALB/c mice. In ex vivo experiments, we studied the effects of naloxone (1 and 10 mg/kg) on receptor binding of [(3)H]-flunitrazepam by membranes of brain fraction (P1+P2) of C57Bl/6 and BALB/c mice. It was shown that naloxone increased motor activity in the open field in BALB/c mice and decreased this parameter in C57Bl/6 mice. During combined treatment, naloxone potentiated the activating effects of phenazepam on the open-field behavior of BALB/c mice and slightly increased the sedative effect of this drug in C57Bl/6 mice. Naloxone stimulated reception of [(3)H]-flunitrazepam in BALB/c mice and slightly increased radioligand binding in C57Bl/6 mice. These data attest to enhanced reception in benzodiazepine site of GABAA-receptor under conditions of opioid receptor blockade, the presence of anxiolytic or sedative (depending on the phenotype of the response to emotional stress) effect of naloxone, and co-directed effects of naloxone and benzodiazepine tranquilizer on open-field behavior of C57Bl/6 and BALB/c mice.

Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen.

Science.gov (United States)

Inglis, Julia J; Criado, Gabriel; Medghalchi, Mino; Andrews, Melanie; Sandison, Ann; Feldmann, Marc; Williams, Richard O

2007-01-01

Many genetically modified mouse strains are now available on a C57BL/6 (H-2b) background, a strain that is relatively resistant to collagen-induced arthritis. To facilitate the molecular understanding of autoimmune arthritis, we characterised the induction of arthritis in C57BL/6 mice and then validated the disease as a relevant pre-clinical model for rheumatoid arthritis. C57BL/6 mice were immunised with type II collagen using different protocols, and arthritis incidence, severity, and response to commonly used anti-arthritic drugs were assessed and compared with DBA/1 mice. We confirmed that C57BL/6 mice are susceptible to arthritis induced by immunisation with chicken type II collagen and develop strong and sustained T-cell responses to type II collagen. Arthritis was milder in C57BL/6 mice than DBA/1 mice and more closely resembled rheumatoid arthritis in its response to therapeutic intervention. Our findings show that C57BL/6 mice are susceptible to collagen-induced arthritis, providing a valuable model for assessing the role of specific genes involved in the induction and/or maintenance of arthritis and for evaluating the efficacy of novel drugs, particularly those targeted at T cells.

Short outlines of books by Estonian authors / Janika Kronberg and Rutt Hinrikus

Index Scriptorium Estoniae

Kronberg, Janika, 1963-

2010-01-01

Arvustus: Kiin, Sirje. Marie Under : elu, luuletaja identiteet ja teoste vastuvõtt. Tallinn : Tänapäev, 2009 ; Laanes, Eneken. Lepitamatud dialoogid : subjekt ja mälu nõukogudejärgses eesti romaanis. Tartu : Tartu Ülikooli Kirjastus, 2009 ; Ehin, Kristiina. Emapuhkus. Tallinn : Pandekt, 2009 ; Tungal, Leelo. Seltsimees laps ja suured inimesed. Tallinn : Tänapäev, 2008 ; Tungal, Leelo. Samet ja saepuru, ehk, Seltsimees laps ja kirjatähed. Tallinn : Tänapäev, 2009 ; Õnnepalu, Tõnu. Paradiis. Tallinn : Varrak, 2009

Role of environment in strengthening competitiveness of cities by example of European Green Capitals and Tallinn

Directory of Open Access Journals (Sweden)

Jüri Ratas

2014-01-01

Full Text Available Guaranteeing a high-level living environment is one of the most important preconditions to the balanced and sustainable economic and social development of the European Union. Serious environmental problems can be seen in European cities, which are the places where most of the population live and which create the highest number of jobs, economic growth and added value. The level of urbanisation in Europe was 72.7% in 2010 and the UN forecast that it will increase to 82.2% by 2050. The European Green Capital Award was created in 2006 in order to recognise cities that have contributed to the improvement of their quality of life. The cities that have won the award have started using the most innovative and efficient measures for increasing the city’s competitiveness, and are an example of how to achieve sustainable development for all cities, not just capitals. The environmental indicators of cities that have won the European Green Capital Award are high. In this article the problem is analysed using the example of Tallinn, the capital of Estonia, which strives for a place among cities with the highest quality of life in Europe. The objective of this article is to analyse the areas of the city’s environmental activities and environmental organisation in the context of increasing competitiveness. The original database used by the author in this article consists of the responses given by the governments of the cities who have already been awarded the title of European Green Capital when asked to describe the impact that applying for and achieving the title had on their cities

Raamatuid / Juhan Habicht

Index Scriptorium Estoniae

Habicht, Juhan, 1954-

1991-01-01

Tutvustused: Kivisildnik, Sven. Dawa vita. Tallinn : Eesti Raamat, [1991]. Uustulnd, Albert. Acheroni kaldal. Tallinn : Eesti Raamat, 1991. Kivikas, Albert. Nimed marmortahvlil. Tallinn : Eesti Raamat, 1991

Induction of autocrine factor inhibiting cell motility from murine B16-BL6 melanoma cells by alpha-melanocyte stimulating hormone.

Science.gov (United States)

Murata, J; Ayukawa, K; Ogasawara, M; Watanabe, H; Saiki, I

1999-03-15

We have previously reported that neuropeptide alpha-melanocyte stimulating hormone (alpha-MSH) successfully inhibited Matrigel invasion and haptotactic migration of B16-BL6 melanoma cells towards both fibronectin and laminin without affecting their growth. In the present study, we investigated the inhibitory mechanism of tumor cell motility by alpha-MSH. Alpha-MSH significantly blocked the autocrine motility factor (AMF)-enhanced cell motility. However, alpha-MSH did neither prevent the secretion of AMF from B16-BL6 cells nor alter the expression level of AMF receptor (gp78). On the other hand, alpha-MSH induced the secretion of the motility inhibitory factor(s) from B16-BL6 cells in a concentration- and time-dependent manner. The induction of the motility inhibitor(s) was proportional to increasing levels of intracellular cAMP induced by alpha-MSH as well as forskolin, and the activity was abolished by an adenylate cyclase inhibitor, 2',5'-dideoxyadenosine (DDA). The motility-inhibiting activity in conditioned medium (CM) from alpha-MSH-treated B16-BL6 cells was found to have a m.w. below 3 kDa after fractionation. This activity was abolished by boiling but insensitive to trypsin. The treatment of tumor cells with cycloheximide reduced the activity in alpha-MSH-stimulated CM. Our results suggest that alpha-MSH inhibited the motility of B16-BL6 cells through induction of autocrine factor(s).

Spontaneous B-L breaking as the origin of the hot early universe

Energy Technology Data Exchange (ETDEWEB)

Buchmueller, W.; Domcke, V.; Schmitz, K.

2012-03-15

The decay of a false vacuum of unbroken B-L symmetry is an intriguing and testable mechanism to generate the initial conditions of the hot early universe. If B-L is broken at the grand unification scale, the false vacuum phase yields hybrid inflation, ending in tachyonic preheating. The dynamics of the B - L breaking Higgs field and thermal processes produce an abundance of heavy neutrinos whose decays generate entropy, baryon asymmetry and gravitino dark matter. We study the phase transition for the full supersymmetric Abelian Higgs model. For the subsequent reheating process we give a detailed time-resolved description of all particle abundances. The competition of cosmic expansion and entropy production leads to an intermediate period of constant 'reheating' temperature, during which baryon asymmetry and dark matter are produced. Consistency of hybrid inflation, leptogenesis and gravitino dark matter implies relations between neutrino parameters and superparticle masses, in particular a lower bound on the gravitino mass of 10 GeV.

Short outlines of books by Estonian authors / Brita Melts and Rutt Hinrikus

Index Scriptorium Estoniae

Melts, Brita

2011-01-01

Arvustus: Vadi, Urmas. Kirjad tädi Annele. Pärnu : Jumalikud Ilmutused, 2010 ; Sommer, Lauri. Kolm yksiklast. Tallinn : Menu Kirjastus, 2010 ; Hargla, Indrek. Apteeker Melchior ja Oleviste mõistatus. Tallinn : Varrak, 2010 ; Hargla, Indrek. Apteeker Melchior ja Rataskaevu viirastus. Tallinn : Varrak, 2010 ; Pihelgas, Carolina. Metsas algavad hääled. Tallinn : Eesti Keele Sihtasutus, 2010

Lycopene pretreatment improves hepatotoxicity induced by acetaminophen in C57BL/6 mice.

Science.gov (United States)

Bandeira, Ana Carla Balthar; da Silva, Rafaella Cecília; Rossoni, Joamyr Victor; Figueiredo, Vivian Paulino; Talvani, André; Cangussú, Silvia Dantas; Bezerra, Frank Silva; Costa, Daniela Caldeira

2017-02-01

Acetaminophen (APAP) is an antipyretic and analgesic drug that, in high doses, leads to severe liver injury and potentially death. Oxidative stress is an important event in APAP overdose. Researchers are looking for natural antioxidants with the potential to mitigate the harmful effects of reactive oxygen species in different models. Lycopene has been widely studied for its antioxidant properties. The aim of this study was to evaluate the antioxidant potential of lycopene pretreatment in APAP-induced liver injury in C57BL/6 mice. C57BL/6 male mice were divided into the following groups: control (C); sunflower oil (CO); acetaminophen 500mg/kg (APAP); acetaminophen 500mg/kg+lycopene 10mg/kg (APAP+L10), and acetaminophen 500mg/kg+lycopene 100mg/kg (APAP+L100). Mice were pretreated with lycopene for 14 consecutive days prior to APAP overdose. Analyses of blood serum and livers were performed. Lycopene was able to improve redox imbalance, decrease thiobarbituric acid reactive species level, and increase CAT and GSH levels. In addition, it decreased the IL-1β expression and the activity of MMP-2. This study revealed that preventive lycopene consumption in C57BL/6 mice can attenuate the effects of APAP-induced liver injury. Furthermore, by improving the redox state, and thus indicating its potential antioxidant effect, lycopene was also shown to have an influence on inflammatory events. Copyright © 2016 Elsevier Ltd. All rights reserved.

Long term monitoring of Gamma-Ray emission from the BL Lacertae object (1ES 2200+420)

Science.gov (United States)

Gunawardhana, Isuru; VERITAS Collaboration

2016-03-01

Blazars are a class of Active Galactic Nuclei (AGN) that have relativistic jets pointing along the observer line of sight. Blazars exhibit variable emission extending from radio to TeV energies. The variability timescale of the TeV flux is a key component of understanding the location of the very high energy emission zones. Deep observations of the quiescent state measurements are also required to disentangle the flaring state emission from quiescent state emission, a prerequisite for understanding the origin of blazar spectral variability. BL Lacertae (also known as 1ES 2200+420), as the namesake for all BL Lac objects, is a prime example of one such blazar. The VERITAS Observatory, an Imaging Atmospheric Cherenkov Telescope (IACT) array sensitive to gamma rays in the range from 85 GeV to 30 TeV, dedicates approximately 110 hours per year on deep observations of known gamma-ray blazars. In this talk, I will describe the TeV photon flux variability of BL Lacertae measured by VERITAS from 2013 to 2015.

B16-BL6 melanoma cells release inhibitory factor(s) of active pump activity in isolated lymph vessels.

Science.gov (United States)

Nakaya, K; Mizuno, R; Ohhashi, T

2001-12-01

We investigated whether supernatant cultured with melanoma cell lines B16-BL6 and K1735 or the Lewis lung carcinoma cell line (LLC) can regulate lymphatic pump activity with bioassay preparations isolated from murine iliac lymph vessels. B16-BL6 and LLC supernatants caused significant dilation of lymph microvessels with cessation of pump activity. B16-BL6 supernatant produced dose-related cessation of lymphatic pump activity. There was no significant tachyphylaxis in the supernatant-mediated inhibitory response of lymphatic pump activity. Pretreatment with 3 x 10(-5) M N(omega)-nitro-L-arginine methyl ester (L-NAME) or 10(-7) M or 10(-6) M glibenclamide and 5 x 10(-4) M 5-hydroxydecanoic acid caused significant reduction of supernatant-mediated inhibitory responses. Simultaneous treatment with 10(-3) M L-arginine and 3 x 10(-5) M L-NAME significantly lessened L-NAME-induced inhibition of the supernatant-mediated response, suggesting that endogenous nitric oxide (NO) plays important roles in supernatant-mediated inhibitory responses. Chemical treatment dialyzed substances of B16-BL6 cells may release nonpeptide substance(s) of <1,000 MW, resulting in significant cessation of lymphatic pump activity via production and release of endogenous NO and activation of mitochondrial ATP-sensitive K(+) channels.

X-ray emission from BL Lac objects: Comparison to the synchrotron self-Compton models

International Nuclear Information System (INIS)

Schwartz, D.A.; Madejski, G.; Ku, W.H.-M.

1982-01-01

As one part of our joint study of the X-ray properties of BL Lac objects, the authors compare the measured X-ray flux densities with those predicted using the synchrotron self-Compton (SSC) formalism (Jones et al. 1974). Naive application of the formalism predicts X-ray fluxes from 10 -3 to 10 5 those observed. They therefore ask what we can learn by simply assuming the SSC mechanism, and looking for ways to reconcile the observed and measured X-ray fluxes. This paper reports investigation of beaming factors due to relativistic ejection of a radiation source which is isotropic in its own rest frame. The authors conclude that large Lorentz factors, GAMMA approximately > 10, do not apply to BL Lac objects as a class. (Auth.)

Kas keegi vajab neid raamatuid? / Jaanika Palm

Index Scriptorium Estoniae

Palm, Jaanika, 1973-

2001-01-01

Rets. rmt. : Müürsepp, Mare. Kolm põrsakest. Punamütsike : muinasjutu-kirjavihik 5-aastastele lastele. 1 vihik / jutustanud, luuletanud ja ülesanded välja mõelnud Mare Müürsepp. Tallinn : Ilo, 2000. Sari "Muinasjutt õpetab" : Hans ja Grete / [idee: Nicole Lenaerts-Viroux. Tallinn] : Egmont Estonia, 2001; Hunt ja seitse kitsetalle / [idee: Nicole Lenaerts-Viroux. Tallinn] : Egmont Estonia, 2000; Lumivalgeke ja seitse pöialpoissi / [idee: Nicole Lenaerts-Viroux. Tallinn] : Egmont Estonia, 2001; Pöial-Liisi / [idee: Nicole Lenaerts-Viroux. Tallinn] : Egmont Estonia, 2000

Maailmalapsed / Janika Kronberg

Index Scriptorium Estoniae

Kronberg, Janika, 1963-

1997-01-01

Sisu: Kareva, Doris. Hingring. Tallinn : Huma, 1997; Kareva, Doris; Tervonen, Marina. Kammertoon. [Tallinn] : D. Kareva ; M. Tervonen, 1997; Gibran, Kahlil. Prohvet / tlk. Doris Kareva. Tallinn : Huma, 1997

On teil mõnda seksiga raamatut kah? / Tauno Vahter

Index Scriptorium Estoniae

Vahter, Tauno

2001-01-01

Arvustus: Bukowski, Charles. Naised / inglise k. tlk. Peeter Sauter. Tallinn : Hotger, 2001 ; Bukowski, Charles. Postkontor / inglise k. tlk. Kaur Kender. Tallinn : Hotger, 2001 ; Jerofejev, Venedikt. Moskva-Petushki / vene k. tlk. Ott Arder. 2. tr. Tallinn Tänapäev, 2001 ; Jerofejev, Venedikt. Psühhopaadi märkmed / vene k. tlk. Igor Kurve. Tallinn : Tänapäev, 2001

[Application of locomotor activity test to evaluate functional injury after global cerebral ischemia in C57BL/6 mice].

Science.gov (United States)

Zhang, Li-quan; Xu, Jia-ni; Wang, Zhen-zhen; Zeng, Li-jun; Ye, Yi-lu; Zhang, Wei-ping; Wei, Er-qing; Zhang, Qi

2014-05-01

To evaluate the application of locomotor activity test in functional injury after global cerebral ischemia (GCI) in C57BL/6 mice. GCI was induced by bilateral carotid arteries occlusion for 30 min in C57BL/6 mice. Mice were divided into sham group, GCI group and minocycline group. Saline or minocycline (45 mg/kg) was i.p. injected once daily for 6 d after ischemia. At Day 6 after ischemia, locomotor activity was recorded for 1 h in open field test. Total distance, central distance, central distance ratio, periphery distance, periphery distance ratio, central time and periphery time were used to evaluate the behavior characteristics of locomotor activity in C57BL/6 mice after ischemia. The survival neuron density was detected by Nissl staining in hippocampus, cortex and striatum. Compared with sham group, total distance, central distance and central time increased and periphery time decreased in C57BL/6 mice after GCI (PsLocomotor activity in open field test can objectively evaluate the behavior injury after GCI in mice. Central distance and central time can be used as indexes of quantitative assessment.

Indomethacin treatment prevents diet-induced obesity and insulin resistance, but not glucose intolerance in C57BL/6J mice

Science.gov (United States)

OBJECTIVE: We performed experiments to examine the metabolic consequences of inhibition of cyclooxygenase (COX) activity in obesity-prone C57BL/6J mice fed a high fat/high sucrose (HF/HS) diet. RESEARCH DESIGN AND METHODS: C57BL/6J mice were fed a HF/HS diet for 7 weeks under thermoneutral conditio...

[Jacqueline Wilson. Tracy Beakeri sari] / Krista Kivisalu

Index Scriptorium Estoniae

Kivisalu, Krista, 1968-

2016-01-01

Tutvustus: Wilson, Jacqueline. Tracy Beakeri lugu. [Tallinn] : Pegasus, 2015 ; Wilson, Jacqueline. Pühadeüllatus. [Tallinn] : Pegasus, c2015 ; Wilson, Jacqueline. Julgusmäng. [Tallinn] : Pegasus, c2015

Raamatud / Juhan Habicht

Index Scriptorium Estoniae

Habicht, Juhan, 1954-

1991-01-01

Raamatutvustused: Beier, Priidu. Mustil päevil. Tallinn : Eesti Raamat, [1991]. Ristikivi, Karl. Inimese teekond : luuletusi. Tallinn : Eesti Raamat, 1991. Erich, Artur. Äike. Tallinn : Eesti Raamat, [1991

Ladina keele õpikud ja sententsikogumikud / Ivo Volt

Index Scriptorium Estoniae

Volt, Ivo, 1975-

2000-01-01

Ka sententsikogumikest: V. Hromov. Dicta et proverbia Latina. Tallinn : Perioodika, 1997 ; 1001 ladina sententsi eesti vastetega. Tallinn : Valgus, 1997 ; K. Türk. Lendsõnade leksikon. Tallinn : Avita, 1998

Utveckling av bestrykning för papper avsedda för bläckstråleskrivare

OpenAIRE

Mattsson, Ylva

2002-01-01

Detta examensarbete har utförts på papperstillverkaren Arjo Wiggins’ forskningscenter i Beaconsfield,England. Företaget har planer på att börja tillverka en ny papperskvalitet för bläckstråleskrivare, varförsyftet med arbetet har varit att testa och utvärdera olika sammansättningar av kemikalier som lämparsig för bestrykning av bläckstrålepapper.Ett stort antal bestrykningar har testats med varierande resultat. Det svåraste har visat sig vara attnå en tillräckligt hög grad av vattenhållfasthe...

Gollandskaja KLM natshinajet poljotõ v Amsterdam / Diana King

Index Scriptorium Estoniae

King, Diana

2005-01-01

Tallinnast alustasid liinilende esmakordselt Eesti turule saabunud lennufirmad: Hollandi KML alustas regulaarlende Tallinn-Amsterdami liinil ning Rootsi tütarfirma Finnair-flyNordic Tallinn-Stockholmi ja Tallinn-Kopenhaageni liinil

Ulmekaravan liigub / Veiko Belials

Index Scriptorium Estoniae

Belials, Veiko, 1966-

2001-01-01

Arvustus: Hargla, Indrek. Pan Grpowski üheksa juhtumit. Tallinn : Kuldsulg, 2001 ; Berg, Lew R. Tempel selvas. Tallinn : Salasõna, 2001 ; Veskimees, Siim. Operatsioon "Ogaline Päike. Tallinn : Fantaasia, 2001

Neutrino mass, leptogenesis and FIMP dark matter in a U(1)_{B-L} model

Science.gov (United States)

Biswas, Anirban; Choubey, Sandhya; Khan, Sarif

2017-12-01

The Standard Model (SM) is inadequate to explain the origin of tiny neutrino masses, the dark matter (DM) relic abundance and the baryon asymmetry of the Universe. In this work, to address all three puzzles, we extend the SM by a local U(1)_{B-L} gauge symmetry, three right-handed (RH) neutrinos for the cancellation of gauge anomalies and two complex scalars having non-zero U(1)_{B-L} charges. All the newly added particles become massive after the breaking of the U(1)_{B-L} symmetry by the vacuum expectation value (VEV) of one of the scalar fields φ _H. The other scalar field, φ _DM, which does not have any VEV, becomes automatically stable and can be a viable DM candidate. Neutrino masses are generated using the Type-I seesaw mechanism, while the required lepton asymmetry to reproduce the observed baryon asymmetry can be attained from the CP violating out of equilibrium decays of the RH neutrinos in TeV scale. More importantly within this framework, we study in detail the production of DM via the freeze-in mechanism considering all possible annihilation and decay processes. Finally, we find a situation when DM is dominantly produced from the annihilation of the RH neutrinos, which are at the same time also responsible for neutrino mass generation and leptogenesis.

Punanahklusest: Majakovskist indiaanlasteni / Vaapo Vaher

Index Scriptorium Estoniae

Vaher, Vaapo, 1945-

2011-01-01

Tutvustus: Jangfeldt, Bengt. Mäng elu peale : Vladimir Majakovski ja tema lähikond / tõlkinud Anu Saluäär. Tallinn : Varrak, 2011 ; Céline, Louis-Ferdinand. Reis öö lõppu / tõlkinud Heli Allik. Tallinn : Varrak, 2010 ; Simone, Claude. Flandria tee / tõlkinud Leena Tomasberg. Tallinn : Eesti Raamat, 2011 ; Härm, Tiiu. Jää voolab : Eesti polaarränduri August Masiku maailm. Tallinn : Eesti Raamat, 2010 ; Page, Jake. Suure vaimu rüpes : Ameerika indiaanlaste 20 000-aastane ajalugu / tõlkinud Matti Piirimaa. Tallinn : Tänapäev, 2011

Silmakirjalik aastasada / Vaapo Vaher

Index Scriptorium Estoniae

Vaher, Vaapo, 1945-

2006-01-01

Tutvustus: Hyvärinen, Pekka. Soome mees : Urho Kekkose elu / tlk. Tauno Vahter. Tallinn : Tänapäev, 2006 ; Tuchman, Barbara W. Augustikahurid / tlk. Armand Tungal ja Tõnis Värnik. Tallinn : Varrak, 2006 ; Ernesaks, Viive. Viiv. Tallinn : Varrak, 2006 ; Kiik, Heino. Leida ennast : 1954-1963. Viies raamat. Tartu : Ilmamaa, 2006 ; Lotman, Juri. Vestlusi vene kultuurist : Vene aadli argielu ja traditsioonid 18. sajandil ja 19. sajandi algul. 2 / [tõlkinud Kajar Pruul]. Tallinn : Tänapäev, 2006 ; Lotman, Mihhail. Pistriku talvekarje : esseid Joseph Brodsky poeetikast ja surmast. Tallinn : Varrak, 2005

Probing BL Lac and Cluster Evolution via a Wide-angle, Deep X-ray Selected Sample

Science.gov (United States)

Perlman, E.; Jones, L.; White, N.; Angelini, L.; Giommi, P.; McHardy, I.; Wegner, G.

1994-12-01

The WARPS survey (Wide-Angle ROSAT Pointed Survey) has been constructed from the archive of all public ROSAT PSPC observations, and is a subset of the WGACAT catalog. WARPS will include a complete sample of >= 100 BL Lacs at F_x >= 10(-13) erg s(-1) cm(-2) . A second selection technique will identify ~ 100 clusters at 0.15 = 0.304 +/- 0.062 for XBLs but = 0.60 +/- 0.05 for RBLs. Models of the X-ray luminosity function (XLF) are also poorly constrained. WARPS will allow us to compute an accurate XLF, decreasing the error bars above by over a factor of two. We will also test for low-luminosity BL Lacs, whose non-thermal nuclear sources are dim compared to the host galaxy. Browne and Marcha (1993) claim the EMSS missed most of these objects and is incomplete. If their predictions are correct, 20-40% of the BL Lacs we find will fall in this category, enabling us to probe the evolution and internal workings of BL Lacs at lower luminosities than ever before. By removing likely QSOs before optical spectroscopy, WARPS requires only modest amounts of telescope time. It will extend measurement of the cluster XLF both to higher redshifts (z>0.5) and lower luminosities (LX<1x10(44) erg s(-1) ) than previous measurements, confirming or rejecting the 3sigma detection of negative evolution found in the EMSS, and constraining Cold Dark Matter cosmologies. Faint NELGs are a recently discovered major contributor to the X-ray background. They are a mixture of Sy2s, starbursts and galaxies of unknown type. Detailed classification and evolution of their XLF will be determined for the first time.

Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen

OpenAIRE

Inglis, Julia J; Criado, Gabriel; Medghalchi, Mino; Andrews, Melanie; Sandison, Ann; Feldmann, Marc; Williams, Richard O

2007-01-01

Many genetically modified mouse strains are now available on a C57BL/6 (H-2b) background, a strain that is relatively resistant to collagen-induced arthritis. To facilitate the molecular understanding of autoimmune arthritis, we characterised the induction of arthritis in C57BL/6 mice and then validated the disease as a relevant pre-clinical model for rheumatoid arthritis. C57BL/6 mice were immunised with type II collagen using different protocols, and arthritis incidence, severity, and respo...

Apteeginaps ajaloomälu turgutuseks / Aet Varik

Index Scriptorium Estoniae

Varik, Aet

2011-01-01

Arvustus: Hargla, Indrek. Apteeker Melchior ja Oleviste mõistatus. Tallinn : Varrak, 2010 ; Apteeker Melchior ja Rataskaevu viirastus. Tallinn : Varrak, 2010 ; Apteeker Melchior ja timuka tütar. Tallinn : Varrak, 2011

Kuula ka neid / Joosep Sang

Index Scriptorium Estoniae

Sang, Joosep

2009-01-01

Tutvustused : XXI Sajandi Orkester. Üheksa. Tallinn : XXISO, 2008. Illustraator. Minu keha. Tallinn : MTÜ ILL Produktsioon, 2008. Pastoraal. Helirännak põldudel ja heinamaadel. Tallinn : Eestimaa Looduse fond, 2008

Lugemisnoppeid: antropoloogia / Marek Tamm

Index Scriptorium Estoniae

Tamm, Marek, 1973-

2012-01-01

Tutvustus: Jürgenson, Aivar. Ladina rahva seas : Argentina ja sealsed eestlased. Tallinn, 2011 ; Annist, Aet. Otsides kogukonda sotsialismijärgses keskuskülas : arenguantropoloogiline uurimus. Tallinn : Tallinna Ülikooli Kirjastus, 2011. (Acta Universitatis Tallinnensis. Socialia) ; Hiiemäe, Reet. Kaitsemaagia eesti rahvausundis. Tallinn, 2012 ; Augé, Marc. Kohad ja mittekohad : sissejuhatus ülimodernsuse antropoloogiasse. Tallinn : Tallinna Ülikooli Kirjastus, 2012. (Bibliotheca controversiarum)

A Comparison of the Effects of Benzalkonium Chloride on Ocular Surfaces between C57BL/6 and BALB/c Mice

Directory of Open Access Journals (Sweden)

Qian Yang

2017-02-01

Full Text Available Models of benzalkonium chloride (BAC-induced ocular disruption have been created and are widely used in various animals. This study aimed to compare the effects of BAC on the ocular surfaces of C57BL/6 and BALB/c mice. C57BL/6 and BALB/c mice were treated separately with BAC eye-drops at different concentrations. Eyes were evaluated by scoring epithelial disruption, corneal opacity and neovascularization in vivo, and by histological assays with hematoxylin/eosin (H/E and periodic acid-Schiff stainings and by determining the expression of inflammatory factors in vitro on Days 7 and 14. The in vivo corneal epithelial disruption, corneal edema/opacity and neovascularization, which were in accordance with the results of the H/E staining and peaked at Day 7, were observed in a dose-dependent manner in the BAC-treated mice, with more severe signs in the C57BL/6 mice than the BALB/c mice. The loss of conjunctival goblet cells in the conjunctivas and the increasing expression of monocyte chemoattractant protein 1 (MCP-1, growth-regulated protein alpha (GROa and macrophage inflammatory protein-1 alpha (MIP-1a in the corneas were found in a dose-dependent manner in both strains of mice. Topical application of BAC can dramatically disrupt the ocular surfaces of C57BL/6 and BALB/c mice, and the disruptions were much more severe in the C57BL/6 mice that received high doses of BAC.

Three Women in Quest of Narrative / Tiina Kirss

Index Scriptorium Estoniae

Kirss, Tiina, 1957-

2008-01-01

Epp Annuse romaanist "Sina, Matilda" (Tallinn : Tuum, 2007), Kärt Hellermaa novellikogust "Ma armastasin David Copperfieldi" (Tallinn : Tuum, 2007) ja Kristiina Ehini lühiproosakogust "Pillipuhujanaine ja pommipanijanaine" (Tallinn : Huma, 2006)

Jaan Ellen talletab rahva valu / Contra

Index Scriptorium Estoniae

Contra, pseud., 1974-

2005-01-01

Raamatud : Ellen, Jaan. Hällimaa. Tallinn, 2004 ; Varjatud valu : mälestusi Teisest maailmasõjast / koostaja Jaan Ellen. Tallinn, 2005 ; Palutedre, Arnold-Johannes. Viis tuhat päeva : [memuaarid]. Tallinn, 2005

Jaan Ellen loob ehedaid elupilte eesti rahva saatusest / Liina Valper

Index Scriptorium Estoniae

Valper, Liina, 1941-

2005-01-01

Raamatud : Ellen, Jaan. Hällimaa. Tallinn, 2004 ; Varjatud valu : mälestusi Teisest maailmasõjast / koostaja Jaan Ellen. Tallinn, 2005 ; Palutedre, Arnold-Johannes. Viis tuhat päeva : [memuaarid]. Tallinn, 2005

Maffia, hullus ja Sannikovi maa / Vaapo Vaher

Index Scriptorium Estoniae

Vaher, Vaapo, 1945-

2011-01-01

Arvustus: Roberts, Gregory David. Shantaram. 1.-2. raamat / tõlkinud Riina Jesmin. Tallinn : Varrak, 2011 ; Akutagawa, Ryūnosuke. Mandariinid tihnikus. Tallinn : Varrak, 2011 ; Põder, Rein. Kauge. Tallinn : Eesti Raamat, 2011

Idiopathic paraproteinemia. III. Increased frequency of paraproteinemia in thymectomized aging C57BL/KaLwRij and CBA/BrARij mice

NARCIS (Netherlands)

Radl, J.; Glopper, E. de; Berg, P. van den; Zwieten, M.J. van

1980-01-01

The influence of thymectomy on the appearance of idiopathic paraproteinemia (IP) during aging was investigated in mice of the C57BL/KaLwRij and CBA/BrARij strains, which under normal conditions develop IP in high and low frequency, respectively. Compared with sham-thymectomized mice, C57BL mice

EFFECTIVENESS OF GLYPHOSATE AND 2.4 D AMIN HERBICIDES TO CONTROL WEEDS UNDER Shorea selanica Bl. PLANTATION IN CARITA TRIAL GARDEN, BANTEN

Directory of Open Access Journals (Sweden)

Ari Wibowo

2007-03-01

Full Text Available A trial was carried out in Carita, West Java, to identify the effectiveness of Glyphosate and 2.4 D Amin Herbicide to control weeds under Shorea selanica Bl. plantation. The trial was conducted through the application of Glyphosate and 2.4 D Amin Herbicide with dosages of 5, 6, 7, 8 and 9 liter per ha and compared with Glyphosate herbicide 5 liter per ha, manual treatment, and control (no treatment. The result showed that Glyphosate and 2.4 D Amin Herbicide could be used to control weeds in order to maintaining S. selanica Bl. plantation. Minimum dosage of 6 liter/ha was effective to control weeds such as Chromolaena odorata DC, Mikania micrantha Will, Lantana camara L, Imperata cylindrica Beauv., Melastoma malabathricum L, and Boreria latifolia Bl. Furthermore, there was no symptom of poison on S. selanica Bl. plantation after herbicide application with all dosages applied.

Oliivipuude triloogia - mõnus suvine võrkkiige-lugemine / Mari Klein

Index Scriptorium Estoniae

Klein, Mari

2007-01-01

Tutvustus: Drinkwater, Carol. Oliiviistandus / tlk. Laine Hone. Tallinn : Varrak, 2004 ; Drinkwater, Carol. Oliivisaak / tlk. Eve-Reet Tammet. Tallinn : Varrak, 2997 ; Drinkwater, Carol. Oliivihooaeg / tlk. Lane Hone ja Karin Rita. Tallinn : Varrak, 2006

Kliiniline kapitalism ja naise neim / Vaapo Vaher

Index Scriptorium Estoniae

Vaher, Vaapo, 1945-

2011-01-01

Tutvustus: Kõiv, Salme. Reet Tammiku. Tallinn : Eesti Raamat, 2011 ; Kalda, Katrin. Eesti romaan / tõlkinud Anti Saar. Tallinn : Varrak, 2011 ; Zola, Émile. Saak / tõlkinud Kaja Riesen. Tallinn : Eesti Raamat, 2011

Characterization in vitro and in vivo of progressively adriamycin-resistant B16-BL6 mouse melanoma cells.

Science.gov (United States)

Ganapathi, R; Grabowski, D; Schmidt, H; Bell, D; Melia, M

1987-07-01

Adriamycin (ADR)-resistant sublines of B16-BL6 mouse melanoma selected by exposure to increasing concentrations of ADR were characterized in vitro for growth properties and in vivo for tumorigenicity and pulmonary metastases. The progressively resistant sublines adapted to grow in the presence of 0.025, 0.05, 0.1, and 0.25 microgram/ml ADR in monolayer culture were found to be 5-, 10-, 20-, and 40-fold ADR-resistant, respectively, compared to the parental sensitive cells, using a soft-agar colony assay and continuous ADR treatment for 7 days. The doubling time in monolayer culture of the parent sensitive and progressively ADR-resistant sublines of B16-BL6 melanoma cells was approximately 16-18 h. Although the colony-forming efficiency in soft agar of parental sensitive cells was only 0.5-4%, the 5-, 10-, 20-, and 40-fold ADR-resistant sublines had colony-forming efficiencies of 15, 20, 30, and 77%, respectively. Tumorigenicity in C57BL/6 mice of progressively ADR-resistant sublines was similar to parental sensitive cells following s.c. and i.p. implantation of 10(5)-10(6) tumor cells. Experimental pulmonary metastases were significantly lower in ADR-resistant sublines with progressive resistance. Additionally, unlike the parental sensitive and 5-fold ADR-resistant B16-BL6 cells, the 10-, 20-, and 40-fold ADR-resistant sublines were spontaneously nonmetastatic. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunochemical detection of P-glycoprotein revealed the presence of a Mr 170,000 plasma membrane glycoprotein in the 40-fold ADR-resistant subline and its counterpart maintained for 1 year in ADR-free medium. Results from this study suggest that progressively ADR-resistant B16-BL6 mouse melanoma cells selected in vitro demonstrate a marked increase in colony formation in soft agar and a decrease in the ability to produce pulmonary metastases, without alterations in tumorigenicity.

Põnevikud kõige väiksematele / Krista Kumberg

Index Scriptorium Estoniae

Kumberg, Krista, 1959-

2006-01-01

Arvustus: Tungal, Leelo. Siil Felix ja kriminaalne loomaaed. Tallinn : Varrak, 2005 ; Tungal, Leelo. Siil Felix ja sekelduste sügis. Tallinn : Varrak, 2005 ; Tungal, Leelo. Hernetont Ernestiine. Tallinn : Eesti Entsüklopeediakirjastus, 2005.

Generation of T-cells reactive to the poorly immunogenic B16-BL6 melanoma with efficacy in the treatment of spontaneous metastases.

Science.gov (United States)

Geiger, J D; Wagner, P D; Cameron, M J; Shu, S; Chang, A E

1993-04-01

The B16-BL6 (BL6) melanoma is a poorly immunogenic murine tumor that is highly invasive and spontaneously metastasizes from the primary site. Utilizing an established anti-CD3/interleukin-2 (IL-2) culture procedure, we have previously reported that lymph nodes (LNs) draining immunogenic murine sarcomas contained preeffector cells that could be activated to differentiate into therapeutic effector cells for adoptive immunotherapy. By contrast, LNs draining the poorly immunogenic BL6 melanoma were found not to be a reliable source of preeffector cells. Instead, sensitization of preeffector cells reactive to BL6 required the subcutaneous inoculation of tumor admixed with Corynebacterium parvum. LN cells draining these vaccination sites demonstrated therapeutic efficacy only after subsequent anti-CD3/IL-2 activation. The sensitization of preeffector cells was dependent on the presence of tumor antigen and an optimal dose of C. parvum ( 140 days. All mice except one that received no treatment or was treated with IL-2 alone succumbed to visceral metastases with an MST of approximately 23 days. This study characterizes a model whereby the weak immune response to the BL6 melanoma can be positively or negatively modulated for the generation of antitumor reactive T-cells useful in adoptive immunotherapy.

[Raamatututvustused] / Ervin Õunapuu

Index Scriptorium Estoniae

Õunapuu, Ervin, 1956-

2007-01-01

Tutvustus: Remarque, Erich Maria. Lissaboni öö. Tallinn : Tänapäev, 2006 ; Jõgisalu, Harri, Tihkan, Lembit. Tulihända püüdmas : lugusid vanalt Läänemaalt. Tallinn : Eesti Raamat, 2001 // Kivirähk, Andrus. Mees, kes teadis ussisõnu. Tallinn : Eesti Keele Sihtasutus, 2007 // Raud, Eno. Tallinn : Ilo, 2005 // Tammsaare, A. H. Sic transit... : kas seni teadlikult "unustatud"?. Muraste : Matrix Kirjastus, 2004

Short outlines of books by Estonian authors / Brita Melts, Rutt Hinrikus and Janika Kronberg

Index Scriptorium Estoniae

Melts, Brita

2015-01-01

Arvustus: Afanasjev, Vahur. Tünsamäe tigu. Tartu Tartu NAK, 2015 ; Vadi, Urmas. Kuidas me kõik reas niimoodi läheme. Tallinn : Tuum, 2014 ; Traat, Mats. Kolm Solveigi. Tartu : Ilmamaa, 2015 ; Saat, Mari. Matused ja laulupeod. Tartu : Petrone Print, 2015 ; Kivisilla, Veronika. Cantus firmus. Tallinn : Näo Kirik, 2015 ; Kolk, Jüri. Suur võidujooks. Tallinn : Tuum, 2015 ; Mudlum. Tõsine inimene. Tallinn : ZA/UM, 2014

Differential Localization of Pain-Related and Pain-Unrelated Neural Responses for Acupuncture at BL60 Using BOLD fMRI

Directory of Open Access Journals (Sweden)

Na-Hee Kim

2013-01-01

Full Text Available The objective of this study was to differentiate between pain-related and pain-unrelated neural responses of acupuncture at BL60 to investigate the specific effects of acupuncture. A total of 19 healthy volunteers were evaluated. fMRI was performed with sham or verum acupuncture stimulation at the left BL60 before and after local anesthesia. To investigate the relative BOLD signal effect for each session, a one-sample t-test was performed for individual contrast maps, and a paired t-test to investigate the differences between the pre- and post-anesthetic signal effects. Regarding verum acupuncture, areas that were more activated before local anesthesia included the superior, middle, and medial frontal gyri, inferior parietal lobule, superior temporal gyrus, thalamus, middle temporal gyrus, cingulate gyrus, culmen, and cerebellar tonsil. The postcentral gyrus was more deactivated before local anesthesia. After local anesthesia, the middle occipital gyrus, inferior temporal gyrus, postcentral gyrus, precuneus, superior parietal lobule, and declive were deactivated. Pre-anesthetic verum acupuncture at BL60 activated areas of vision and pain transmission. Post-anesthetic verum acupuncture deactivated brain areas of visual function, which is considered to be a pain-unrelated acupuncture response. It indicates that specific effects of acupoint BL60 are to control vision sense as used in the clinical setting.

MRP-1 expression levels determine strain-specific susceptibility to sodium arsenic-induced renal injury between C57BL/6 and BALB/c mice

International Nuclear Information System (INIS)

Kimura, Akihiko; Ishida, Yuko; Wada, Takashi; Yokoyama, Hitoshi; Mukaida, Naofumi; Kondo, Toshikazu

2005-01-01

To clarify the pathophysiological mechanism underlying acute renal injury caused by acute exposure to arsenic, we subcutaneously injected both BALB/c and C57BL/6 mice with sodium arsenite (NaAs; 13.5 mg/kg). BALB/c mice exhibited exaggerated elevation of serum blood urea nitrogen (BUN) and creatinine (CRE) levels, compared with C57BL/6 mice. Moreover, half of BALB/c mice died by 24 h, whereas all C57BL/6 mice survived. Histopathological examination on kidney revealed severe hemorrhages, acute tubular necrosis, neutrophil infiltration, cast formation, and disappearance of PAS-positive brush borders in BALB/c mice, later than 10 h. These pathological changes were remarkably attenuated in C57BL/6 mice, accompanied with lower intrarenal arsenic concentrations, compared with BALB/c mice. Among heavy metal inducible proteins including multidrug resistance-associated protein (MRP)-1, multidrug resistance gene (MDR)-1, metallothionein (MT)-1, and arsenite inducible, cysteine- and histidine-rich RNA-associated protein (AIRAP), intrarenal MDR-1, MT-1, and AIRAP gene expression was enhanced to a similar extent in both strains, whereas NaAs challenge augmented intrarenal MRP-1 mRNA and protein expression levels in C57BL/6 but not BALB/c mice. Moreover, the administration of a specific inhibitor of MRP-1, MK-571, significantly exaggerated acute renal injury in C57BL/6 mice. Thus, MRP-1 is crucially involved in arsenic efflux and eventually prevention of acute renal injury upon acute exposure to NaAs

Absorption in the spectra of quasi stellar objects and BL Lac objects

International Nuclear Information System (INIS)

Perry, J.J.; Burbidge, E.M.; Burbidge, G.R.

1978-06-01

An extensive review is given of the observations of absorption in the spectra of QSOs and BL Lac objects. In Table Ia we summarize all of the information available up to May 1, 1978 on objects which show absorption. Following discussion of the observations in Section II, possible interpretations are critically discussed. (orig.) [de

Short outlines of books by Estonian authors / Janika Kronberg, Rutt Hinrikus

Index Scriptorium Estoniae

Kronberg, Janika, 1963-

2006-01-01

Arvustus: Runnel, Hando. Sinamu. Tartu : Ilmamaa, 2005 ; Talvet, Jüri. Tõrjumatu äär. Tartu : Ilmamaa, 2005 ; Nõu, Enn. Mõtusekuke viimne kogupauk. Tallinn : Eesti Keele Sihtasutus, 2005 ; Merca. Hele häärber. Tartu : Vilep & Vallik, 2005 ; Õnnepalu, Tõnu. Enne heinaaega ja hiljem : luulet ja luuletõlkeid 1983-2005. Tallinn : Eesti Keele Sihtasutus, 2005 ; Kaplinski, Jaan. Kõik on ime. Tartu : Ilmamaa, 2004 ; Unt, Mati. Vend Antigone, ema Oidipus. Tallinn : Kultuurileht, 2006 ; Laretei, Käbi. Otsekui tõlkes : teema variatsioonidega. Tallinn : Tänapäev, 2005 ; Jõerüüt, Jaak. Sõber : valik novelle 1979-2005. Tallinn : Tuum, 2005

Tumedad ained kirjanduses ja päriselt / Mare Müürsepp

Index Scriptorium Estoniae

Müürsepp, Mare

2007-01-01

Analüüsitud on Philip Pullmani triloogiasse "Tema tumedad ained" kuuluvaid romaane : Pullman, Philip. Kuldne kompass. Tallinn : Tiritamm, 2002; Pullman, Philip. Inglite torn. Tallinn : Tiritamm, 2004; Pullman, Philip. Vaigust kiiker. Tallinn : Tiritamm, 2005

[Eve Hele Sits. Mooni talurahva tähtpäevik ; Mooni metsauudistaja ; Mooni Eestimaa raamat ] / Helja Kirber ; suomennos Katariina Suurpalo

Index Scriptorium Estoniae

Kirber, Helja

2014-01-01

Tutvustus: Sits, Eve Hele. Mooni talurahva tähtpäevik. [Tallinn] : Argo, c2011; Mooni metsauudistaja : tähelepanekuid ja lugusid metsaelust. [Tallinn] : Argo, c2012; Mooni Eestimaa raamat. [Tallinn] : Argo, c2013

Kolm Goncourt'i laureaati korraga / Marek Tamm

Index Scriptorium Estoniae

Tamm, Marek, 1973-

2002-01-01

Arvustus: Tournier, Michel. Haldjakuningas / tlk. Laine Hone. Tallinn : Eesti Raamat, 2002 ; Rouaud, Jean. Auväljad / tlk. Vladimir Indrikson. Tallinn : Atlantis, 2002 ; Roze, Pascale. Hävituslendur Zéro / tlk. Kaja Riesen. Tallinn : Olion, 2002

Eesti vajab oma Richelieu'd / Vaapo Vaher

Index Scriptorium Estoniae

Vaher, Vaapo, 1945-

2006-01-01

Tutvustus: Faulkner, William. Sartoris / tõlkinud Vilma Jürisalu. Tallinn : Eesti Raamat, 2005 ; Runnel, Hando. Sinamu. Tartu : Ilmamaa, 2005 ; Levi, Anthony. Richelieu. Tallinn : Varrak, 2005 ; Lõvi, Oskar. Kolm naist [1-3]. Tallinn : Varrak, 2005

Cis-bifenthrin induces immunotoxicity in adolescent male C57BL/6 mice.

Science.gov (United States)

Wang, Xia; Gao, Xingli; He, Bingnan; Zhu, Jiawei; Lou, Huihui; Hu, Qinglian; Jin, Yuanxiang; Fu, Zhengwei

2017-07-01

Bifenthrin (BF) is an important synthetic pyrethroid. Previous studies have demonstrated that cis-BF exhibits toxic effects on development, the neurological, reproductive and endocrine system. In this study, we evaluated the immunotoxicity caused by cis-BF in adolescent male C57BL/6 mice. Mice were exposed orally to 0, 5, 10, and 20 mg/kg/d for 3 weeks. The results showed that body weight, spleen weight, and splenic cellularity decreased in mice exposed to 20 mg/kg/d cis-BF. Additionally, we found that the mRNA levels of the pro-inflammatory factors IL-1β, IL-6, CXCL-1, and TNF-α, in peritoneal macrophages, the spleen, and the thymus were inhibited in the cis-BF-treated groups. Moreover, MTT assays demonstrated that cis-BF inhibited splenocyte proliferation stimulated by LPS or Con A, as well as the secretion of IFN-γ on Con A stimulation. Collectively, the results of this study suggest that exposure to cis-BF has the potential to induce immunotoxicity in adolescent male C57BL/6 mice. © 2017 Wiley Periodicals, Inc.

High frequency mechanical ventilation affects respiratory system mechanics differently in C57BL/6J and BALB/c adult mice.

Science.gov (United States)

Hadden, Hélène

2013-01-15

We tested the hypothesis that high frequency ventilation affects respiratory system mechanical functions in C57BL/6J and BALB/c mice. We measured respiratory mechanics by the forced oscillation technique over 1h in anesthetized, intubated, ventilated BALB/c and C57BL/6J male mice. We did not detect any change in airway resistance, Rn, tissue damping, G, tissue elastance, H and hysteresivity, eta in BALB/c mice during 1h of ventilation at 150 or at 450 breaths/min; nor did we find a difference between BALB/c mice ventilated at 150 breaths/min compared with 450 breaths/min. Among C57BL/6J mice, except for H, all parameters remained unchanged over 1h of ventilation in mice ventilated at 150 breaths/min. However, after 10 and 30 min of ventilation at 450 breaths/min, Rn, and respiratory system compliance were lower, and eta was higher, than their starting value. We conclude that high frequency mechanical ventilation affects respiratory system mechanics differently in C57BL/6J and BALB/c adult mice. Copyright © 2012 Elsevier B.V. All rights reserved.

Masses and pulsations of BL Herculis variables

International Nuclear Information System (INIS)

Hodson, S.W.; Cox, A.N.; King, D.S.

1981-01-01

From linear results, the masses of BL Her variables must be nearer to 0.55 M /sub sun/ than 0.75 M /sub sun/ if the bump phase transition (resonance) is to be located anywhere near the observed period range of 1./sup d/5 to 1./sup d/7. The nonlinear results are consistent with the Simon resonance concept, but demonstrate that light and velocity curve shapes are a nonlinear phenomenon that require nonlinear period ratios to display the resonances only in the narrow, observed range of 1./sup d/5 to 1./sup d/7. The mass near 0.55 M /sub sun/ is in good agreement with evolution calculations (Sweigart and Gross, 1976) and nonlinear pulsation studies of Carson, Stothers, and Vemury (1981) and Stothers

3Corners of the World / Joosep Sang

Index Scriptorium Estoniae

Sang, Joosep

2009-01-01

Arvustused : Robert Jürjendal, Petri Kuljuntausta, David Rothenberg. 3Corners of the World. [Tallinn] : Terra Nova Music, 2008. Nadia ja Fragile. Uhke ali. [Tallinn] : Nadia & Fragile, 2008. UMA. Civitas Soli. [Tallinn] : Elwood, 2008. Uutest heliplaatidest

Kolm, keda miski ei seo / Veiko Märka

Index Scriptorium Estoniae

Märka, Veiko, 1964-

2004-01-01

Arvustus: Jõerüüt, Jaak. Uus raamat : [luuletused]. Tallinn : Tuum, 2004 ; Maiste, Juhan. In Arcadia ego : [luuletused]. Tallinn : J. Maiste, 2004 ; Essa, Maario. Kellegi teise muru : debüütluulekogu. Tallinn : SE & JS, 2004 ;

Ilusast eesti keelest / Ruth Mägi

Index Scriptorium Estoniae

Mägi, Ruth, 1974-

2008-01-01

Kirjastuse TEA sõnaraamatutest: TEA koolisõnastik : eesti keel. Tallinn : TEA Kirjastus, 2008 ; TEA eesti keele rahvasõnaraamat koos õigekirjareeglitega. Tallinn : TEA Kirjastus, 2008 ; TEA rahvasõnaraamat : võõrsõnad. Tallinn : TEA Kirjastus, 2006

Identification of immunodominant Leishmania major antigenic markers of the early C57BL/6 and BALB/c mice infection stages.

Science.gov (United States)

Sassi, Atfa; Kaak, Olfa; Elgaaied, Amel Benammar

2015-08-24

The C57BL/6 mouse strain is resistant to Leishmania (L.) major infection and, unlike susceptible BALB/c, develops small self healing cutaneous lesions. The specific antibody responses of C57BL/6 and BALB/c mice were previously characterized by the predominance of IgG2a ("resistant" isotype associated with Th1) and IgG1 ("pathogenic" isotype associated with Th2) antibodies, respectively. In this study, we looked for the presence of antigens able to elicit an exclusive or predominant IgG1 production during the early stages of C57BL/6 lesion development and checked whether they are recognized or not by BALB/c mice. We demonstrate first that IgG2a predominance in C57BL/6 sera occurs only late after infection whereas in BALB/c, IgG1 antibodies dominate mostly in the early stages. Interestingly, soon after inoculation of live amastigotes, C57BL/6 displayed an exclusive IgG1 reactivity against particular L. major antigens but with MWs different from those identified in BALB/c. Furthermore, mice immunized with killed amastigotes displayed striking differences in their immunodetection profiles, particularly for the IgG1 isotype. Taken together, the observed differences in the specific antibody repertoires between infected mice resulted, at least in part, from immunological events independent from those triggered by the replicating parasite, and bring new insights into the selection of future vaccine candidates. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Computing Optical Variable Periods of BL Lac Object S5 0716+714 ...

Indian Academy of Sciences (India)

2016-01-27

Jan 27, 2016 ... From a large volume of literature, we have collected effective observation of BL Lac object S5 0716+714 in the optical band, and constructed its long-term light curve from 1994 to 2006 AD. The light curve shows that S5 0716+714 is very active and exhibits very complicated non-sinusoidal variations.

Aino Kalda päevikud : Valgus ja varjud ; Valguse ja varju segu ; Hingesillad ; Rikas, kuhjaga täis / Hilve Rebane

Index Scriptorium Estoniae

Rebane, Hilve, 1938-2012

2003-01-01

Arvustus: Kallas, Aino. Pärjapunuja. Päevaraamat aastaist 1897-1900. Tallinn : Eesti Raamat, 1994 ; Kallas, Aino. Jäätunud šampanja. Päevaraamat aastaist 1907-1915. Tallinn : Eesti Raamat, 1994 ; Kallas, Aino. Hingesild. Päevikulehti aastaist 1916-1921. Tallinn : Eesti Raamat, 1993 ; Kallas, Aino. Suurlinnade udus ja säras. Päevaraamat aastaist 1922-1926. Tallinn : Eesti Raamat, 1996 ; Kallas, Aino. Pööripäevad. Päevaraamat aastaist 1927-1931

Closure Plan for Corrective Action Unit 110: Area 3 RWMS U-3ax/bl Disposal Unit, Nevada Test Site, Nevada

International Nuclear Information System (INIS)

Fitzmaurice, T. M.

2000-01-01

This Closure Plan has been prepared for the Area 3 RWMS U-3ax/bl Disposal Unit Corrective Action Unit 110 in accordance with the Federal Facility and Consent Order (Nevada Division of Environmental Protection [NDEP] et al., 1996). The U-3ax/bl is a historic disposal unit within the Area 3 Radioactive Waste Management Site located on the Nevada Test Site (NTS). The unit, which was formed by excavating the area between two subsidence craters (U-3ax and U-3bl), was operationally closed in 1987. The U-3ax/bl disposal unit is scheduled for permanent closure under the Resource Conservation and Recovery Act as a hazardous waste landfill. Existing records indicate that, from July 1968 to December 1987, U-3ax/bl received 2.3 x 10 5 cubic meters (8.12 x 10 6 cubic feet) of waste. NTS nuclear device testing generated approximately 95 percent of the total volume disposed of in U-3ax/bl, the majority of which came from the Waste Consolidation Project (80 percent of the total volume) (Elletson and Johnejack, 1995). Area 3 is located in Yucca Flat, within the northeast quadrant of the NTS. The Yucca Flat watershed is a structurally closed basin encompassing an area of approximately 780 square kilometers (300 square miles). The structural geomorphology of Yucca Flat is typical of the Basin and Range Physiographic Province. Yucca Flat lies in one of the most arid regions of the country. Water balance calculations for Area 3 indicate that it is continuously in a state of moisture deficit. The U-3ax/bl Disposal Unit will be closed in place by installing a Resource Conservation and Recovery Act equivalent cover. Following cover construction a fence will be installed around the cover to prevent accidental damage to the cover. Post-closure monitoring will consist of site inspections to determine the condition of the engineered cover and cover performance monitoring using Time-Domain Reflectometry arrays to monitor moisture migration in the cover. Any identified maintenance and repair

Closure Plan for Corrective Action Unit 110: Area 3 RWMS U-3ax/bl Disposal Unit, Nevada Test Site, Nevada

Energy Technology Data Exchange (ETDEWEB)

T. M. Fitzmaurice

2000-08-01

This Closure Plan has been prepared for the Area 3 RWMS U-3ax/bl Disposal Unit Corrective Action Unit 110 in accordance with the Federal Facility and Consent Order (Nevada Division of Environmental Protection [NDEP] et al., 1996). The U-3ax/bl is a historic disposal unit within the Area 3 Radioactive Waste Management Site located on the Nevada Test Site (NTS). The unit, which was formed by excavating the area between two subsidence craters (U-3ax and U-3bl), was operationally closed in 1987. The U-3ax/bl disposal unit is scheduled for permanent closure under the Resource Conservation and Recovery Act as a hazardous waste landfill. Existing records indicate that, from July 1968 to December 1987, U-3ax/bl received 2.3 x 10{sup 5} cubic meters (8.12 x 10{sup 6} cubic feet) of waste. NTS nuclear device testing generated approximately 95 percent of the total volume disposed of in U-3ax/bl, the majority of which came from the Waste Consolidation Project (80 percent of the total volume) (Elletson and Johnejack, 1995). Area 3 is located in Yucca Flat, within the northeast quadrant of the NTS. The Yucca Flat watershed is a structurally closed basin encompassing an area of approximately 780 square kilometers (300 square miles). The structural geomorphology of Yucca Flat is typical of the Basin and Range Physiographic Province. Yucca Flat lies in one of the most arid regions of the country. Water balance calculations for Area 3 indicate that it is continuously in a state of moisture deficit. The U-3ax/bl Disposal Unit will be closed in place by installing a Resource Conservation and Recovery Act equivalent cover. Following cover construction a fence will be installed around the cover to prevent accidental damage to the cover. Post-closure monitoring will consist of site inspections to determine the condition of the engineered cover and cover performance monitoring using Time-Domain Reflectometry arrays to monitor moisture migration in the cover. Any identified maintenance and

Strawinsky: Ragtime, Oktett für Bläser, Neeme Järvi / Werner Pfister

Index Scriptorium Estoniae

Pfister, Werner

1995-01-01

Uuest heliplaadist "Strawinsky: Ragtime, Oktett für Bläser, Die Geschichte vom Soldaten (Suite), Petruschka. Royal Scottish National Orchestra, Orchestre de la Suisse Romande, Neeme Järvi". (AD: 1986-93). Chandos/Koch CD 9291 (WD:74'40")

[Raamat] / Elina Kalm

Index Scriptorium Estoniae

Kalm, Elina

2007-01-01

Tutvustus: Stroud, Jonathan. Samarkandi amulett / tlk. Bibi Raid. Tallinn : Pegasus, 2005 ; Stroud, Jonathan. Golemi silm / tlk. Bibi Raid. Tallinn : Pegasus, 2007 ; Stroud, Jonathan. Ptolemaiose värav / tlk. Bibi Raid. Tallinn : Pegasus, 2007. (Bartimaeuse triloogia ; 1-3)

Seks on parem kui Pelevin / Vaapo Vaher

Index Scriptorium Estoniae

Vaher, Vaapo, 1945-

2011-01-01

Tutvustus: Pelevin, Viktor. Libalooma Püha Raamat / tõlkinud Maiga Varik. Tallinn : Varrak, 2011 ; Weber, Andreas. Kõik me tunneme / tõlkinud Krista Räni. Tallinn : Varrak, 2011 ; Vella, Juri. Järvetuul / tõlkinud Art Leete. Tallinn : Varrak, 2011

Kirjanduskriitikute suvemängud / Kärt Hellerma

Index Scriptorium Estoniae

Hellerma, Kärt, 1956-

2007-01-01

Arvustus: Lodge, David. Ühest kohast teise / tlk. Aet Varik. Tallinn : Varrak, 2005 ; Lodge, David. Väike maailm / tlk. Kersti Unt. Tallinn : Varrak, 1996 ; Lodge, David. Väärt töö / tlk. Kersti Unt. Tallinn : Varrak, 2006

Uusi raamatuid / Lauri Eesmaa

Index Scriptorium Estoniae

Eesmaa, Lauri

2011-01-01

Tutvustus: Dante Alighieri. Jumalik komöödia : Põrgu. Tallinn : Eesti Keele Sihtasutus, 2011. Perec, Georges. Ruumiliigid. Tallinn : Kultuurileht, 2011. Kadare, Ismail. Kuri aasta / albaania keelest tõlkinud Kalle Kasemaa. Tallinn : Kultuurileht, 2011 (Loomingu Raamatukogu ; 17-18/2011)

Õdusad Inglise lastelood / Triin Tael

Index Scriptorium Estoniae

Tael, Triin

2008-01-01

Tutvustus: Potter, Beatrix. Lugu Benjamin Nudisabast. Tallinn : Ilo, c2008 ; Potter, Beatrix. Lugu Orav Käbikäpast. Tallinn : Ilo, c2008 ; Potter, Beatrix. Lugu Peeter Pikk-Kõrvast. Tallinn : Ilo, c2008. Ka Astrid Lindgrenist ja tema raamatutest

Viiv: sügis 1963-1973 : Viivi Luige luule jaapanlikkus / Külliki Kuusk

Index Scriptorium Estoniae

Kuusk, Külliki, 1975-

2007-01-01

Viivi Luige luulekogude "Taevaste tuul" (Tallinn : Eesti Raamat, 1966), "Lauludemüüja" (Tallinn : Eesti Raamat, 1968) ja "Hääl" (Tallinn : Perioodika, 1968) poeetikast. Uku Masingu ja Viivi Luige seotusest, jaapani luule mõjudest Viivi Luige loomingule

EXPERIMENTAL SUBCUTANEOUS CYSTICERCOSIS BY Taenia crassiceps IN BALB/c AND C57BL/6 MICE.

Science.gov (United States)

Pereira, Íria Márcia; Lima, Sarah Buzaim; Freitas, Aline de Araújo; Vinaud, Marina Clare; Junior, Ruy de Souza Lino

2016-07-11

Human cysticercosis is one of the most severe parasitic infections affecting tissues. Experimental models are needed to understand the host-parasite dynamics involved throughout the course of the infection. The subcutaneous experimental model is the closest to what is observed in human cysticercosis that does not affect the central nervous system. The aim of this study was to evaluate macroscopically and microscopically the experimental subcutaneous cysticercosis caused by Taenia crassiceps cysticerci in BALB/c and C57BL/6 mice. Animals were inoculated in the dorsal subcutaneous region and macroscopic and microscopic aspects of the inflammatory process in the host-parasite interface were evaluated until 90 days after the inoculation (DAI). All the infected animals presented vesicles containing cysticerci in the inoculation site, which was translucent at 7 DAI and then remained opaque throughout the experimental days. The microscopic analysis showed granulation tissue in BALB/c mice since the acute phase of infection evolving to chronicity without cure, presenting 80% of larval stage cysticerci at 90 DAI. While C57BL/6 mice presented 67% of final stage cysticerci at 90 DAI, the parasites were surrounded by neutrophils evolving to the infection control. It is possible to conclude that the genetic features of susceptibility (BALB/c) or resistance (C57BL/6) were confirmed in an experimental subcutaneous model of cysticercosis.

Neutrino mass, leptogenesis and FIMP dark matter in a U(1){sub B-L} model

Energy Technology Data Exchange (ETDEWEB)

Biswas, Anirban; Khan, Sarif [Harish-Chandra Research Institute, Allahabad (India); Homi Bhabha National Institute, Training School Complex, Mumbai (India); Choubey, Sandhya [Harish-Chandra Research Institute, Allahabad (India); Homi Bhabha National Institute, Training School Complex, Mumbai (India); AlbaNova University Center, Department of Theoretical Physics, School of Engineering Sciences, KTH Royal Institute of Technology, Stockholm (Sweden)

2017-12-15

The Standard Model (SM) is inadequate to explain the origin of tiny neutrino masses, the dark matter (DM) relic abundance and the baryon asymmetry of the Universe. In this work, to address all three puzzles, we extend the SM by a local U(1){sub B-L} gauge symmetry, three right-handed (RH) neutrinos for the cancellation of gauge anomalies and two complex scalars having non-zero U(1){sub B-L} charges. All the newly added particles become massive after the breaking of the U(1){sub B-L} symmetry by the vacuum expectation value (VEV) of one of the scalar fields φ{sub H}. The other scalar field, φ{sub DM}, which does not have any VEV, becomes automatically stable and can be a viable DM candidate. Neutrino masses are generated using the Type-I seesaw mechanism, while the required lepton asymmetry to reproduce the observed baryon asymmetry can be attained from the CP violating out of equilibrium decays of the RH neutrinos in TeV scale. More importantly within this framework, we study in detail the production of DM via the freeze-in mechanism considering all possible annihilation and decay processes. Finally, we find a situation when DM is dominantly produced from the annihilation of the RH neutrinos, which are at the same time also responsible for neutrino mass generation and leptogenesis. (orig.)

Effects of BCL oral administation and herbal acupuncture at BL18, BL19 on Liver function changes induced by Alcohol in the mice

Directory of Open Access Journals (Sweden)

Sa-Hyun Park

2002-02-01

Full Text Available This dissertation was designed to evaluate the effect of BCL(refinded Bambusae Caulis in Liqua-men oral administration and herbal acupuncture on alcohol metabolism and liver function. For this study. mice were damaged by a large quantity of alcohol and received treatment of either BCL 1 mg/kg in oral or BCL 250㎍/kg in herbal acupuncture-BL18 . BL19 bilateral. and then such parameters as GOT. GPT. catalase and superoxide dismustase(CuZn-SOD, Mn-SOD were measured. The results of the experiments were summarized as follows. 1. Compared with control group, the proper degree of alcohol in serum was not significantly differ from oral administration group and herbal acupuncture group. 2. Compared with control group. the activity of GOT in serum was significantly reduced both oral administration and herbal acupuncture group. 3. Compared with control group. the activity of GPT in serum was significantly reduced both oral administration and herbal acupuncture group. 4. The activity of catalase in liver cell tissue, compared with control group. was not sigificantly affected either by oral administration and herbal acupuncture group. 5. The activity of CuZn-SOD in liver cell tissue was not significantly change in herbal acupuncture and oral administration group. The activity of Mn-SOD was significantly increased in oral administration group. while it was not the case in acupuncture group. In conclusion. we consider that BCL oral administration and herbal acupuncture is highly effetive in recovering alcohol metabolism and liver disfunction induced by alcohol.

Venemaa lähiajalugu : hajamõtteid uuematest tõlkeraamatutest / Tõnu Tannberg

Index Scriptorium Estoniae

Tannberg, Tõnu, 1961-

2000-01-01

Arvustus: Radzinski, Edvard. Stalin. Tallinn : Varrak, 2000 ; Rubin, Nikolai. Lavrenti Beria : müüt ja reaalsus. Tallinn : Olion, 2000 ; Sudoplatov, Pavel. Erioperatsioonid : Ljubjanka ja Kreml 1930-1950. Tallinn : Olion, 2000. Ka venekeelse ajalookirjanduse eestindamisel üldiselt esinevatest probleemidest

Fantacy't erinevale maitsele / Sash Uusjärv

Index Scriptorium Estoniae

Uusjärv, Sash

2011-01-01

Arvustus: Westerfeld, Scott. Inetud / inglise keelest tõlkinud Maali Käbin. Tallinn : Varrak, 2011; Flinn, Alex. Koletu / inglise keelest tõlkinud Kret Kaasik. Tallinn : Varrak, 2010 ; Banner, Catherine. Kuninga silmad / inglise keelest tõlkinud Tanel Rõigas. Tallinn : Varrak, 2011

Genistein suppresses adhesion-induced protein tyrosine phosphorylation and invasion of B16-BL6 melanoma cells.

Science.gov (United States)

Yan, C; Han, R

1998-07-03

Protein tyrosine phosphorylation occurs as one of the earlier events in cancer cell-extracellular matrix (ECM) interaction. With immunoblot analysis and immunofluorescence microscopy, genistein was found to suppress the tyrosine phosphorylation of proteins located at the cell periphery, including a 125 kDa protein, when B16-BL6 melanoma cells attached to and interacted with ECM. When accompanied by the suppression of adhesion-induced protein tyrosine phosphorylation, the invasive potential of B16-BL6 cells through reconstituted basement membrane was decreased significantly. However, neither adhesive capability nor cell growth was significantly affected by genistein. Therefore, the interruption of cancer cell-ECM interaction by suppression of protein tyrosine phosphorylation may contribute to invasion prevention of genistein.

Alternative Site Technology Deployment-Monitoring System for the U-3ax/bl Disposal Unit at the Nevada Test Site

International Nuclear Information System (INIS)

Dixon, J.M.; Levitt, D.G.; Rawlinson, S.E.

2001-01-01

In December 2000, a performance monitoring facility was constructed adjacent to the U-3ax/bl mixed waste disposal unit at the Nevada Test Site (NTS). Recent studies conducted in the arid southwestern United States suggest that a vegetated monolayer evapotranspiration (ET) closure cover may be more effective at isolating waste than traditional Resource Conservation and Recovery Act (RCRA) multi-layered designs. The monitoring system deployed next to the U-3ax/bl disposal unit consists of eight drainage lysimeters with three surface treatments: two are left bare; two are revegetated with native species; two are being allowed to revegetate with invader species; and two are reserved for future studies. Soil used in each lysimeter is native alluvium taken from the same location as the soil used for the cover material on U-3ax/bl. The lysimeters were constructed so that any drainage to the bottom can be collected and measured. To provide a detailed evaluation of the cover performance, an ar ray of 16 sensors was installed in each lysimeter to measure soil water content, soil water potential, and soil temperature. Revegetation of the U-3ax/bl closure cover establishes a stable plant community that maximizes water loss through transpiration while at the same time, reduces water and wind erosion and ultimately restores the disposal unit to its surrounding Great Basin Desert environment

Lastevihkaja Daniil Harms ja puuslik Leonid Iljitš Brežnev / Vaapo Vaher

Index Scriptorium Estoniae

Vaher, Vaapo, 1945-

2011-01-01

Tutvustus: Harms, Daniil. Väljapudunevad vanaeided / tõlkinud Ilona Martson ja Rein Saluri. Tallinn : Tänapäev, 2011 ; Bourget, Paul. Õpilane / tõlkinud Kattri Ezzoubi. Tallinn : Eesti Raamat, 2011 ; Mletšin, Leonid. Brežnev. Tallinn : Varrak, 2011

Hasso Krulli eepiline pesamuna / Rein Veidemann

Index Scriptorium Estoniae

Veidemann, Rein, 1946-

2015-01-01

Eesti Kultuurkapitali aastapreemia laureaat Hasso Krull. Arvustus: Krull, Hasso. Pesa : tekstid 2000-2012. Tallinn : Eesti Keele Sihtasutus, 2014 ; Krull, Hasso. Muna : tekstid 1987-2012. Tallinn : Eesti Keele Sihtasutus, 2014 ; Krull, Hasso. Kui kivid olid veel pehmed. Tallinn : Eesti Keele Sihtasutus, 2014

Four vision of contemporary Estonian art : the series of exhibitions Estonian art / Heie Treier

Index Scriptorium Estoniae

Treier, Heie, 1963-

2000-01-01

Neljast eesti kunsti näitusest 2000. a. märtsis-aprillis Tartus ja Tallinnas, nende kuraatoritest: Toomas Vint, Reet Varblane, Peeter Allik, Johannes Saar. Déj́-vu (Tallinn). Naturalism (Tallinn). AIDS kultuuris (Tallinn). Eneseksjäämine (Tartu)

Gastrodia elata Bl. Attenuated learning deficits induced by forced-swimming stress in the inhibitory avoidance task and Morris water maze.

Science.gov (United States)

Chen, Pei-Ju; Liang, Keng-Chen; Lin, Hui-Chen; Hsieh, Ching-Liang; Su, Kuan-Pin; Hung, Mei-Chu; Sheen, Lee-Yan

2011-06-01

This study adopted the forced-swimming paradigm to induce depressive symptoms in rats and evaluated the effects on learning and memory processing. Furthermore, the effects of the water extract of Gastrodia elata Bl., a well-known Chinese traditional medicine, on amnesia in rats subjected to the forced-swimming procedure were studied. Rats were subjected to the forced-swimming procedure, and the inhibitory avoidance task and Morris water maze were used to assess learning and memory performance. The acquisition of the two tasks was mostly impaired after the 15-minute forced-swimming procedure. Administration of the water extract of G. elata Bl. for 21 consecutive days at a dosage of 0.5 or 1.0 g/kg of body weight significantly improved retention in the inhibitory avoidance test, and the lower dose showed a better effect than the higher one and the antidepressant fluoxetine (18 mg/kg of body weight). In the Morris water maze, the lower dose of the water extract of G. elata Bl. significantly improved retention by shortening escape latency in the first test session and increasing the time in searching the target zone during the probe test. These findings suggest that water extracts of G. elata Bl. ameliorate the learning and memory deficits induced by forced swimming.

An efficient chronic unpredictable stress protocol to induce stress-related responses in C57BL/6 mice.

Science.gov (United States)

Monteiro, Susana; Roque, Susana; de Sá-Calçada, Daniela; Sousa, Nuno; Correia-Neves, Margarida; Cerqueira, João José

2015-01-01

Exposure to chronic stress can have broad effects on health ranging from increased predisposition for neuropsychiatric disorders to deregulation of immune responses. The chronic unpredictable stress (CUS) protocol has been widely used to study the impact of stress exposure in several animal models and consists in the random, intermittent, and unpredictable exposure to a variety of stressors during several weeks. CUS has consistently been shown to induce behavioral and immunological alterations typical of the chronic stress-response. Unfortunately C57BL/6 mice, one of the most widely used mouse strains, due to the great variety of genetically modified lines, seem to be resistant to the commonly used 4-week-long CUS protocol. The definition of an alternative CUS protocol allowing the use of C57BL/6 mice in chronic stress experiments is a need. Here, we show that by extending the CUS protocol to 8 weeks is possible to induce a chronic stress-response in C57BL/6 mice, as revealed by abrogated body weight gain, increased adrenals weight, and an overactive hypothalamic-pituitary-adrenal axis with increased levels of serum corticosterone. Moreover, we also observed stress-associated behavioral alterations, including the potentiation of anxious-like and depressive-like behaviors and a reduction of exploratory behavior, as well as subtle stress-related changes in the cell population of the thymus and of the spleen. The present protocol for C57BL/6 mice consistently triggers the spectrum of CUS-induced changes observed in rats and, thus, will be highly useful to researchers that need to use this particular mouse strain as an animal model of neuropsychiatric disorders and/or immune deregulation related to CUS.

Fluorescence In Vivo Hybridization (FIVH) for Detection of Helicobacter pylori Infection in a C57BL/6 Mouse Model

DEFF Research Database (Denmark)

Fontenete, Sílvia; Leite, Marina; Cappoen, Davie

2016-01-01

). Finally, the efficiency of FIVH to detect H. pylori SS1 strain in C57BL/6 infected mice was evaluated ex vivo in mucus samples, in cryosections and paraffin-embedded sections by epifluorescence and confocal microscopy. RESULTS: H. pylori SS1 strain infecting C57BL/6 mice was successfully detected...... by the Cy3_HP_LNA/2OMe_PS probe in the mucus, attached to gastric epithelial cells and colonizing the gastric pits. The specificity of the probe for H. pylori was confirmed by microscopy. CONCLUSIONS: In the future this methodology can be used in combination with a confocal laser endomicroscope for in vivo......INTRODUCTION: In this study, we applied fluorescence in vivo hybridization (FIVH) using locked nucleic acid (LNA) probes targeting the bacterial rRNA gene for in vivo detection of H. pylori infecting the C57BL/6 mouse model. A previously designed Cy3_HP_LNA/2OMe_PS probe, complementary...

Parandada püksipõlve augu väljalõikamise teel / Jaak Tomberg

Index Scriptorium Estoniae

Tomberg, Jaak, 1980-

2010-01-01

Arvustus: Saar, Anti. Kuidas sa ära läksid ja mina maha jäin : [jutud]. Tallinn : Eesti Keele Sihtasutus, 2006 ; Saar, Anti. Nemad kaks : [lühiromaan]. Tallinn : Eesti Keele Sihtasutus, 2008 ; Tekste siledast ruumist : [jutud]. Tallinn : Eesti Keele Sihtasutus, 2009

Nii, nagu oli, seal, kus oli / Heili Sibrits

Index Scriptorium Estoniae

Sibrits, Heili, 1977-

2010-01-01

Arvustus: Goodwin, Jason. Janitšaride puu : [romaan] / inglise keelest tõlkinud Juhan Habicht. Tallinn : Varrak, 2006 ; Goodwin, Jason. Maokivi : [kriminaalromaan] / inglise keelest tõlkinud Juhan Habicht. Tallinn : Varrak, 2008 ; Goodwin, Jason. Bellini kaart / inglise keelest tõlkinud Juhan Habicht. Tallinn : Varrak, 2010

Pilk uuele "Põhjamaade romaani" sarjale / Hilve Rebane

Index Scriptorium Estoniae

Rebane, Hilve, 1938-2012

1999-01-01

Bengtson, Frans G. Orm Punane / tlk. Anu Saluäär. Tallinn : Eesti Raamat, 1997 ; Wassmo, Herbjırg. Dina raamat / tlk. Elvi Lumet. Tallinn : Eesti Raamat, 1997 ; Tunström, Göran. Varas / tlk. Ene Mäe. Tallinn : Eesti Raamat, 1999

Surnud mehe käsi / Veiko Belials

Index Scriptorium Estoniae

Belials, Veiko, 1966-

1997-01-01

Arvustus: Asimov, Isaac. Asum / inglise k. tlk. Linda Ariva. Tallinn : Eesti Raamat, 1985. (Mirabilia); Asimov, Isaac. Asum ja impeerium / inglise k. tlk. Linda Ariva. Tallinn : Eesti Raamat, 1989. (Mirabilia); Asimov, Isaac. Teine asum / inglise k. tlk. Indrek Elling. Tallinn : Eesti Raamat, 1996. (Mirabilia)

Telliskivist Peeter Suureni / Vaapo Vaher

Index Scriptorium Estoniae

Vaher, Vaapo, 1945-

2005-01-01

Tutvustus: Fowles, John. Daniel Martin / inglise keelest tõlkinud Viktoria Traat. Tallinn : Varrak, 2005 ; Undset, Sigrid. Põlev põõsas / norra keelest tõlkinud Elvi Lumet. Tallinn : Eesti Raamat, 2005 ; Hughes, Lindsey. Peeter Suur / inglise keelest tõlkinud Lauri Vahtre. Tallinn : Varrak, 2005

Tallinna, Riia ja Helsingi ajaloolised atlased / Tõnis Liibek

Index Scriptorium Estoniae

Liibek, Tõnis, 1976-

2013-01-01

Arvustus: Tallinn ajaloolistel linnaplaanidel 1634-1989 [kaart] = Maps of the City of Tallinn =Tallinn auf den Stadtplanen = Планы города Таллинна. Tallinn, 2011 ; Margarita Barzdeviča. Rīga zviedru laika kartēs un plānos 1621-1710. Latvijas Vēstures Insitūta Apgāds. Rīga, 2011 ; Helsinki - Helsingfors. Historiallinen kaupunkikartasto - Historic Towns Atlas. Helsinki, 2009

Book reviews / Carolina Pihelgas, Peeter Helme and Jan Kaus

Index Scriptorium Estoniae

Pihelgas, Carolina, 1986-

2016-01-01

Arvustus: Sommer, Lauri. Kunagi: 2008-2015. Räestu [Võrumaa] : Tiivaalune, 2015 ; Rooste, Jürge. Ideaalne abikaasa. Saarde ; Pärnu : [Jumalikud Ilmutused], 2015 ; Ruitlane, Olavi. Vee peal. Tallinn : ZA/UM, 2015 ; Riismaa, Kaur. Pühamägi. Tallinn : Verb, 2015 ; Riismaa, Kaur. Pimeda mehe aiad. Tallinn : Tänapäev, 2015 ; Raud, Rein. Täiusliku lause surm. Tallinn : Mustvalge Kirjastus, 2015 ; Matsin, Paavo. Gogoli disko. Viljandi : Lepp ja Nagel, 2015 ; Lennuk, Urmas. Ükskord Eestimaal. Viljandi : Ugala Teater, 2015

Vadja sõnaraamat kui kunstiteos / Kristiina Ross

Index Scriptorium Estoniae

Ross, Kristiina, 1955-

2011-01-01

Arvustus: Vadja keele sõnaraamat. 1 / toimetanud Elna Adler, Merle Leppik. Tallinn : AE Signalet, 1990 ; Vadja keele sõnaraamat. 2, [K -küüttöseltšä] = Словарь водского языка. 2 / toimetanud Elna Adler, Merle Leppik. [Tallinn] ; [Tallinn] : Teaduste Akadeemia Kirjastus, 1994 ; Vadja keele sõnaraamat. 3, L - müüäG] = Словарь водского языка / toimetanud Elna Adler, Merle Leppik. [Tallinn] ; [Tallinn] : Eesti Keele Instituut, 1996 ; Vadja keele sõnaraamat. 4, [N - P] = Словарь водского языка. 4, [N - P] / toimetanud: Elna Adler, Merle Leppik. [Tallinn] : Eesti Keele Sihtasutus, 2000 ; Vadja keele sõnaraamat. 5, [R-S] = Словарь водского языка. 5, [R-S] / toimetanud Silja Grünberg. Tallinn : Eesti Keele Sihtasutus, 2006 ; Vadja keele sõnaraamat. 6, [Š-T] = Словарь водского языка. 6, [Š-T] / toimetanud Silja Grünberg. Tallinn : Eesti Keele Sihtasutus, 2010 ; Vadja keele sõnaraamat. 7 = Словарь водского языка / toimetanud Silja Grünberg. Tallinn : Eesti Keele Sihtasutus, 2011

Probiotic Lactobacillus acidophilus NCFM and Bifidobacterium animalis subsp lactis Bl-04 interactions with prebiotic carbohydrates using differential proteomics and protein characterization

DEFF Research Database (Denmark)

Hansen, Morten Ejby

of probiotics, primarily non-digestible carbohydrates, are termed prebiotics. The knowledge of prebiotic utilization and in particular the specificities of carbohydrate transport and metabolism are limited, hampering robust understanding for the basis of selective utilization of known prebiotics...... and the discovery and documentation of novel ones. In this project we set out to investigate the metabolism of carbohydrates that are prebiotic or potential prebiotic compounds utilized by the probiotic organisms Lactobacillus acidophilus NCFM (NCFM) and Bifidobacterium animalis subsp. lactis BL-04 (Bl-04). The aim...... of this Ph.D. thesis was the study of probiotic NCFM and Bl-04 interaction with prebiotic carbohydrates using differential proteomics and protein characterization. Proteomics is a potential omics tool to investigate probiotic bacteria and its response to prebiotic carbohydrates at the protein level...

Head lood halvast ajast / Karl Martin Sinijärv

Index Scriptorium Estoniae

Sinijärv, Karl Martin, 1971-

2003-01-01

Arvustus: Akunin, Boriss. Azazel : romaan / vene keelest tõlkinud Jüri Ojamaa. [Tallinn] : Tänapäev, 2003; Akunin, Boriss. Türgi gambiit : romaan / vene keelest tõlkinud Veronika Einberg. [Tallinn] : Tänapäev, 2003; Akunin, Boriss. Leviathan. Tallinn : Tänapäev, 2003

Elu mütoloogilises psühhoruumis / Vaapo Vaher

Index Scriptorium Estoniae

Vaher, Vaapo, 1945-

2009-01-01

Tutvustus: Lukjanenko, Sergei. Öine Vahtkond / tlk. Tanel Rõigas. Tallinn : Varrak, 2008 ; Rubina, Dina. Päikeselisel tänavapoolel / tlk. Veronika Einberg. Tallinn : Tänapäev, 2008 ; Suhhotšev, Aleksandr. Goa sündroom / tlk. Veronika Einberg. Tallinn : Tänapäev, 2008

Igal puul oma õunad ehk Kõnekäände mitmel teemal : [uusi raamatuid rahvapärastest ütlustest] / Asta Õim

Index Scriptorium Estoniae

Õim, Asta, 1943-

2002-01-01

Arvustus: Tere, tere, teid ma tunnen ...: Soove, tervitusi, tänamisi / koost. Anne Hussar. Tallinn, 2002 ; Elevant voodi all, voodi lae all : keerdküsimusi loomadest / koost. Piret Voolaid. Tallinn, 2002 ; Mis sa soiud, võta soodat! : Sajatusi, osatusi, parastamisi / koost. Anneli Baran. Tallinn, 2002

Behavioral architecture of opioid reward and aversion in C57BL/6 substrains

Directory of Open Access Journals (Sweden)

Stacey L Kirkpatrick

2015-01-01

Full Text Available Drug liking versus drug disliking is a subjective motivational measure in humans that assesses the addiction liability of drugs. Variation in this trait is hypothesized to influence vulnerability versus resilience toward substance abuse disorders and likely contains a genetic component. In rodents and humans, conditioned place preference (CPP / aversion (CPA is a Pavlovian conditioning paradigm whereby a learned preference for the drug-paired environment is used to infer drug liking whereas a learned avoidance or aversion is used to infer drug disliking. C57BL/6 inbred mouse substrains are nearly genetically identical, yet demonstrate robust differences in addiction-relevant behaviors, including locomotor sensitization to cocaine and consumption of ethanol. Here, we tested the hypothesis that B6 substrains would demonstrate differences in the rewarding properties of the mu opioid receptor agonist oxycodone (5 mg/kg, i.p. and the aversive properties of the opioid receptor antagonist naloxone (4 mg/kg, i.p.. Both substrains showed similar degrees of oxycodone-induced CPP; however, there was a three-fold enhancement of naloxone-induced CPA in agonist-naïve C57BL/6J relative to C57Bl/6NJ mice. Exploratory factor analysis of CPP and CPA identified unique factors that explain variance in behavioral expression of reward versus aversion. Conditioned Opioid-Like Behavior was a reward-based factor whereby drug-free locomotor variables resembling opioid treatment co-varied with the degree of CPP. Avoidance and Freezing was an aversion-based factor, whereby the increase in the number of freezing bouts co-varied with the degree of aversion. These results provide new insight into the behavioral architecture of the motivational properties of opioids. Future studies will use quantitative trait locus mapping in B6 substrains to identify novel genetic factors that contribute to the marked strain difference in NAL-CPA.

Complete genome sequence of the aerobic facultative methanotroph Methylocella silvestris BL2.

Science.gov (United States)

Chen, Yin; Crombie, Andrew; Rahman, M Tanvir; Dedysh, Svetlana N; Liesack, Werner; Stott, Matthew B; Alam, Maqsudul; Theisen, Andreas R; Murrell, J Colin; Dunfield, Peter F

2010-07-01

Methylocella silvestris BL2 is an aerobic methanotroph originally isolated from an acidic forest soil in Germany. It is the first fully authenticated facultative methanotroph. It grows not only on methane and other one-carbon (C(1)) substrates, but also on some compounds containing carbon-carbon bonds, such as acetate, pyruvate, propane, and succinate. Here we report the full genome sequence of this bacterium.

Soft X-ray observations of two BL Lacertae objects - markarian 421 and 501

International Nuclear Information System (INIS)

Singh, K.P.; Garmire, G.P.

1985-01-01

This paper reports on the soft X-ray (0.15-2.8 keV) observations of two BL Lacertae-type objects, viz., Mrk 421 and Mrk 501. The observations were made with the low-energy detectors on the HEAO 1 satellite during the period 1977 August-1978 December. Steep, soft X-ray power-law spectra with photon index Gamma = 3 are found for both Mrk 421 and Mrk 501. The power-law models are found to give a significantly better fit than the thermal models to the observed pulse-height spectra of Mrk 421 and Mrk 501. Day-to-day soft X-ray (0.25 keV band) intensity variations are observed only in Mrk 501. No significant change is found in Gamma from both the BL Lac objects during the period of observations. However, the sum of all the X-ray observations from 1976 until 1980 can be understood in terms of two spectral components of variable intensity to account for the X-ray emission observed between 0.15 and 20 keV from Mrk 421 and Mrk 501. 24 references

Using the Markov chain Monte Carlo method to study the physical properties of GeV-TeV BL Lac objects

Science.gov (United States)

Qin, Longhua; Wang, Jiancheng; Yang, Chuyuan; Yuan, Zunli; Mao, Jirong; Kang, Shiju

2018-01-01

We fit the spectral energy distributions (SEDs) of 46 GeV-TeV BL Lac objects in the frame of leptonic one-zone synchrotron self-Compton (SSC) model and investigate the physical properties of these objects. We use the Markov chain Monte Carlo (MCMC) method to obtain the basic parameters, such as magnetic field (B), the break energy of the relativistic electron distribution (γ ^' }b), and the electron energy spectral index. Based on the modeling results, we support the following scenarios for GeV-TeV BL Lac objects. (1) Some sources have large Doppler factors, implying other radiation mechanism should be considered. (2) Compared with flat spectrum quasars (FSRQs), GeV-TeV BL Lac objects have weaker magnetic fields and larger Doppler factors, which cause the ineffective cooling and shift the SEDs to higher bands. Their jet powers are around 4.0 × 1045 erg s-1, compared with radiation power, 5.0 × 1042 erg s-1, indicating that only a small fraction of jet power is transformed into the emission power. (3) For some BL Lacs with large Doppler factors, their jet components could have two substructures, e.g., the fast core and the slow sheath. For most GeV-TeV BL Lacs, Kelvin-Helmholtz instabilities are suppressed by their higher magnetic fields, leading to micro-variability or intro-day variability in the optical bands. (4) Combined with a sample of FSRQs, an anti-correlation between the peak luminosity, Lpk, and the peak frequency, νpk, is obtained, favoring the blazar sequence scenario. In addition, an anti-correlation between the jet power, Pjet, and the break Lorentz factor, γb, also supports the blazar sequence.

Diverse manifestations of tumorigenicity and immunogenicity displayed by the poorly immunogenic B16-BL6 melanoma transduced with cytokine genes.

Science.gov (United States)

Arca, M J; Krauss, J C; Strome, S E; Cameron, M J; Chang, A E

1996-05-01

We evaluated the in vivo response to the poorly immunogenic B16-BL6 (BL6) murine melanoma genetically altered to secrete interleukin-2 (IL-2), IL-4, interferon gamma (IFN gamma) and granulocyte/macrophage-colony-stimulating factor (GM-CSF). Three parameters were evaluated: (1) tumorigenicity, (2) vaccination of naive animals, and (3) assessment of antitumor reactivity of T cells derived from tumor-draining lymph nodes (TDLN). Secretion of IL-2 abrogated the tumorigenicity of BL6, while IFN gamma and IL-4 partially reduced tumorigenicity, and GM-CSF had no effect. Protective immunity to wild-type tumor challenge could not be achieved by vaccination with irradiated cytokine-secreting tumors, although IL-2 and IL-4 secretion appeared to retard the growth of the challenge inoculum significantly. An alternative method to evaluate the immunogenicity of the cytokine-secreting tumors was to measure the ability of T cells obtained from TDLN to mediate regression of wild-type tumor in adoptive immunotherapy. Neither IL-2 nor IFN gamma secretion resulted in the induction of immune T cells. By contrast, GM-CSF and IL-4 secretion were found to induce immune T cells in the TDLN with GM-CSF being superior to IL-4. The combined secretion of GM-CSF and IL-4 did not lead to enhanced induction of immune T cells. GM-CSF secretion was found to upregulate B7-1 expression in TDLN, consistent with an increase in the population of antigen-presenting cells. These studies demonstrated that reduced tumorigenicity by cytokine secretion did not correlate with increased immunogenicity. With the cytokines examined, there was limited capability of developing protective immunity against the BL6 tumor. Nevertheless, GM-CSF and IL-4 secretion significantly enhanced T cell immune reactivity to the poorly immunogenic BL6 tumor.

Olfactory bulb proteins linked to olfactory memory in C57BL/6J mice.

Science.gov (United States)

Li, Lin; Mauric, Veronika; Zheng, Jun-Fang; Kang, Sung Ung; Patil, Sudarshan; Höger, Harald; Lubec, Gert

2010-08-01

Information on systematic analysis of olfactory memory-related proteins is poor. In this study, the odor discrimination task to investigate olfactory recognition memory of adult male C57BL/6J mice was used. Subsequently, olfactory bulbs (OBs) were taken, proteins extracted, and run on two-dimensional gel electrophoresis with in-gel-protein digestion, followed by mass spectrometry and quantification of differentially expressed proteins. Dual specificity mitogen-activated protein kinase kinase 1 (MEK1), dihydropyrimidinase-related protein 1 (DRP1), and fascin are related with Lemon odor memory. Microtubule-associated protein RP/EB family member 3 is related to Rose odor memory. Hypoxanthine-guanine phosphoribosyltransferase is related with both Lemon and Rose odors memory. MEK1 and DRP1 levels were increased, while microtubule-associated protein RP/EB family member 3, fascin and hypoxanthine-guanine phosphoribosyltransferase levels were decreased during olfactory memory. In summary, neurogenesis, signal transduction, cytoskeleton, and nucleotide metabolism are involved in olfactory memory formation and storage of C57BL/6J mice.

Kolmekordne kupar / Rein Saluri

Index Scriptorium Estoniae

Saluri, Rein

1998-01-01

Arvustus: Kristof, Agota. Kaustik; Katsumus; Kolmas vale / prantsuse k. tlk. Urmas Rattus. Tallinn : Varrak, 1997. (Moodne klassika); Oz, Amos. Ära ütle, et öö / heebrea k. tlk. Kalle Kasemaa. Tallinn : Kupar, 1998; Weldon, Fay. Kuu Minneapolise kohal / inglise k. tlk. Faina Laksberg. Tallinn : Kupar, 1997

Õ, ehk, Loovtöötaja kottimine / Sven =Kivisildnik

Index Scriptorium Estoniae

Kivisildnik, Sven, pseud., 1964-

2001-01-01

Arvustus: Sinijärv, Karl Martin. Towntown & 28 : viies rühm poeese. Tallinn : Varrak, 1999 ; Sinijärv, Karl Martin. Sobimus. Tallinn : Artmiks, 1999 ; Neid vigu me ei korda / Asko Künnap, Jürgen Rooste, Karl Martin Sinijärv. Tallinn : Näo Kirik, 2000

Iharus iseenda järele / Vaapo Vaher

Index Scriptorium Estoniae

Vaher, Vaapo, 1945-

2006-01-01

Tutvustus: Gide, André. Surra, et elada / tlk. Leena Tomasberg. Tallinn : Varrak, 2006 ; Soosaar, Martti. Lase vareseid! Tallinn : Tänapäev, 2006 ; Otsides : Juhan Peegel. Meenutusi pikalt teelt / koost. Maarja Lõhmus. Tallinn : Tänapäev, 2006 ; Steffenson, Jakob. Meie, ruhnlased. Tartu : A. Tuulberg, 2006

Kiima kroonikad / Ainiki Väljataga

Index Scriptorium Estoniae

Väljataga, Ainiki

1997-01-01

Arvustus: Mirtem, Valev [Luhaäär, Ingvar]. Valge õis sinisel. S.l., 1996; Mirtem, Valev [Luhaäär, Ingvar]. Loire. Tallinn, 1996; Mirtem, Valev [Luhaäär, Ingvar]. Klaasist lepatriinu. Tallinn, 1996; Mirtem, Valev [Luhaäär, Ingvar]. Toomingais ja sireleis. Tallinn, 1996

Maurice Car̊me'i lihtsad laulud lastele / Helle Michelson

Index Scriptorium Estoniae

Michelson, Helle, 1929-

2003-01-01

Car̊me, Maurice. Muinasjutud Caprine'ile / tõlkinud Helle Michelson. [Tallinn] : Tiritamm, 2002 ; Car̊me, Maurice. Naeruhull kirsipuu : [luuletused] / prantsuse keelest tõlkinud Helvi Jürisson. [Tallinn] : Tiritamm, 2002 ; Car̊me, Maurice. Margareetapäev : [jutustused] / tõlkinud Helle Michelson. [Tallinn] : Varrak, 2000

An efficient chronic unpredictable stress protocol to induce stress-related responses in C57BL/6 mice

Directory of Open Access Journals (Sweden)

Susana eMonteiro

2015-02-01

Full Text Available Exposure to chronic stress can have broad effects on health ranging from increased predisposition for neuropsychiatric disorders to deregulation of immune responses. The chronic unpredictable stress (CUS protocol has been widely used to study the impact of stress exposure in several animal models and consists in the random, intermittent and unpredictable exposure to a variety of stressors during several weeks. CUS has consistently been shown to induce behavioral and immunological alterations typical of the chronic stress response. Unfortunately C57BL/6 mice, one of the most widely used mouse strains, due to the great variety of genetically modified lines, seem to be resistant to the commonly used 4-week-long CUS protocol. The definition of an alternative CUS protocol allowing the use of C57BL/6 mice in chronic stress experiments is a need. Here we show that by extending the CUS protocol to 8 weeks is possible to induce a chronic stress response in C57BL/6 mice, as revealed by abrogated body weight gain, increased adrenals weight and an overactive hypothalamic-pituitary-adrenal (HPA axis with increased levels of serum corticosterone. Moreover, we also observed stress-associated behavioral alterations, including the potentiation of anxious-like and depressive-like behaviors and a reduction of exploratory behavior, as well as subtle stress-related changes in the cell population of the thymus and of the spleen.The present protocol for C57BL/6 mice consistently triggers the spectrum of CUS-induced changes observed in rats and, thus, will be highly useful to researchers that need to use this particular mouse strain as an animal model of neuropsychiatric disorders and/or immune deregulation related to chronic unpredictable stress.

Late inflammatory and thrombotic changes in irradiated hearts of C57BL/6 wild-type and atherosclerosis-prone ApoE-deficient mice

Energy Technology Data Exchange (ETDEWEB)

Patties, I.; Glasow, A. [University of Leipzig, Department of Radiation Therapy, Leipzig (Germany); Haagen, J. [University of Technology, Department of Radiotherapy and Radiation Oncology, Medical Faculty Carl Gustav Carus, Dresden (Germany); Doerr, W. [University of Technology, Department of Radiotherapy and Radiation Oncology, Medical Faculty Carl Gustav Carus, Dresden (Germany); CCC, Medical University/AKH, Department of Radiation Oncology and Christian Doppler Laboratory for Medical Radiation Research for Radiooncology, Vienna (Austria); Hildebrandt, G. [University of Rostock, Department of Radiotherapy and Radiation Oncology, Rostock (Germany)

2014-09-09

Radiation-induced heart disease represents a late complication of thoracic radiotherapy. We investigated the inflammatory and thrombotic response after local heart irradiation in wild-type and atherosclerosis-prone mice. Atherosclerosis-prone ApoE{sup -/-} and C57BL/6 wild-type mice were sacrificed 20, 40, and 60 weeks after irradiation with 0.2, 2, 8, or 16 Gy. The expression of CD31, vascular cell adhesion molecule-1 (VCAM-1), thrombomodulin (TM), and CD45 were quantified by immunofluorescence staining of heart tissue sections. Microvascular density decreased at 40 weeks after 16 Gy in C57BL/6 but not in ApoE{sup -/-} mice. CD31 expression declined in C57BL/6 mice at 40 weeks (8 Gy), but increased in ApoE{sup -/-} mice at 20 (2/8/16 Gy) and 60 weeks (16 Gy). Capillary area decreased in C57BL/6 at 40 weeks (8/16 Gy) but increased in ApoE{sup -/-} mice at 20 weeks (16 Gy). Endocardial VCAM-1 expression remained unchanged. TM-positive capillaries decreased at 40 weeks (8/16 Gy) in C57BL/6 and at 60 weeks (2/16 Gy) in ApoE{sup -/-} mice. Leukocyte infiltration transiently rose 40 weeks after 8 Gy (only ApoE{sup -/-}) and 16 Gy. After receiving a low irradiation dose of 0.2 Gy, no significant changes were observed in any of the mouse models. This study demonstrated that local heart irradiation affects microvascular structure and induces inflammatory/thrombotic responses in mice in a dose- and time-dependent manner. Thereby, significant prothrombotic changes were found in both strains, although they were progressive in ApoE{sup -/-} mice only. Proinflammatory responses, like the increase of adhesion molecules and leukocyte infiltration, were more pronounced and occurred at lower doses in ApoE{sup -/-} vs. C57BL/6 mice. These findings indicate that metabolic risk factors, such as decreased ApoE lipoproteins, may lead to an enhanced proinflammatory and prothrombotic late response in locally irradiated hearts. (orig.) [German] Strahlungsinduzierte kardiovaskulaere

Magnolia Extract (BL153 Ameliorates Kidney Damage in a High Fat Diet-Induced Obesity Mouse Model

Directory of Open Access Journals (Sweden)

Wenpeng Cui

2013-01-01

Full Text Available Accumulating evidence demonstrated that obesity is a risk factor for renal structural and functional changes, leading to the end-stage renal disease which imposes a heavy economic burden on the community. However, no effective therapeutic method for obesity-associated kidney disease is available. In the present study, we explored the therapeutic potential of a magnolia extract (BL153 for treating obesity-associated kidney damage in a high fat diet- (HFD- induced mouse model. The results showed that inflammation markers (tumor necrosis factor-α and plasminogen activator inhibitor-1 and oxidative stress markers (3-nitrotyrosine and 4-hydroxy-2-nonenal were all significantly increased in the kidney of HFD-fed mice compared to mice fed with a low fat diet (LFD. Additionally, proteinuria and renal structure changes in HFD-fed mice were much more severe than that in LFD-fed mice. However, all these alterations were attenuated by BL153 treatment, accompanied by upregulation of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α and hexokinase II (HK II expression in the kidney. The present study indicates that BL153 administration may be a novel approach for renoprotection in obese individuals by antiinflammation and anti-oxidative stress most likely via upregulation of PGC-1α and HK II signal in the kidney.

The effects of benzil amino purin (BAP and gibberellin with in vitro seedling growth of pulesari (Alyxia reinwardtii Bl

Directory of Open Access Journals (Sweden)

Heru Sudrajad

2016-12-01

Full Text Available Latar belakang: Status kelangkaan pulesari (Alyxia reinwardtii Bl. termasuk rawan (vulnerable karena tingginya permintaan dan mahalnya harga menyebabkan eksploitasi pulesari di hutan meningkat sedangkan upaya konservasi dan budidayanya belum ada. Selama ini perbanyakan pulesari hanya mengandalkan biji di alam. Benih pulesari persentase perkecambahannya tergolong sangat rendah, waktu lama dan sulit diperbanyak secara vegetatif. Memperhatikan sulitnya mendapatkan bibit pulesari secara konvensional maka perlu dilakukan dengan cara kultur jaringan. Metode: Penelitian dilakukan di laboratorium kultur jaringan Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional Tawangmangu selama tiga bulan. Bibit A. reinwardtii Bl. diperoleh dari Pringgondani Forest, Tawangmangu. Biji kupas dan dikeringkan selama lima hari, dicuci menggunakan aquadest steril, direndam pada 0,5% Agrept 5 menit kemudian pada 2,125% natrium hipochorida 5 menit dan dibilas menggunakan aquades steril. Media Murashige dan Skoog (MS disiapkan sesuai komposisi. Penelitian ini rancangan acak lengkap (RAL pola faktorial. Faktor pertama konsentrasi zat pengatur tumbuh BAP pada konsentrasi 3, 4 dan 5 mg/l dan faktor kedua konsentrasi giberelin dari 1, 2 dan 3 mg/l. Media MS yang dimodifikasi dengan penambahan BAP konsentrasi 3, 4, dan 5 mg/l dan giberelin konsentrasi 1, 2, dan 3 mg/l sehingga diperoleh 9 kombinasi perlakuan. Hasil: Hasil penelitian menunjukkan bahwa kombinasi perlakuan zat pengatur tumbuh BAP  mg/l dan giberelin 2 mg/l pada media MS terbentuk tunas dan akar. Tunas terbentuk pada 30 hari setelah tanam dengan tinggi 2 cm dan akar muncul pada 45 hari setelah tanam dalam satu kali percobaan. Kesimpulan: Pulesari (Alyxia reinwardtii Bl. dapat diperbanyak melalui kultur jaringan menggunakan biji sebagai eksplan. Kaca kunci : pulesari, Alyxia reinwardtii Bl, BAP dan giberelin Abstract Background: Alyxia reinwardtii Bl. in natural habitat becomes rare and reaches

Modulation of B16-BL6 murine melanoma metastatic phenotype by tyrosine and phenylalanine restriction in the absence of host selection pressures.

Science.gov (United States)

Elstad, C A; Meadows, G G

1993-01-01

We previously showed that restriction of tyrosine (Tyr) and phenylalanine (Phe) in vivo dramatically suppresses the metastatic phenotype of B16-BL6 (BL6) murine melanoma. Present results indicate a direct effect of Tyr and Phe restriction on the tumor in the absence of host selection pressures. Lung colonizing ability of BL6 is dramatically suppressed after one passage in vitro in media containing low levels of Tyr and Phe. This antimetastatic effect is immediate, stable for at least 5 in vitro passages in Tyr and Phe restricted media, and evident event after levels of Tyr and Phe are restored to normal. Heterogeneity for lung colonizing ability is suppressed, as evidence by fewer tumor colonies formed by clones following i.v. inoculation into mice fed normal diet. This suppression of BL6 metastatic phenotype is not due to differential clearance and retention in the lung or to decreased growth, but is specific for these two amino acids. As the mechanism(s) for the antitumor effects of Tyr and Phe restriction are detailed, the relevance of Tyr and Phe restriction as an early adjuvant to effective cancer treatment can be explored.

Quercetin inhibits the invasion and mobility of murine melanoma B16-BL6 cells through inducing apoptosis via decreasing Bcl-2 expression.

Science.gov (United States)

Zhang, X; Xu, Q; Saiki, I

2000-01-01

Quercetin has been known to have anti-tumor and anti-oxidation activities. In the present study, we have investigated its in vitro anti-metastatic activity. Quercetin inhibited the invasion and mobility of murine melanoma B16-BL6 cells in a dose-dependent manner but did not affect their adhesion to either laminin, fibronectin, or type VI collagen. Moreover, quercetin significantly inhibited the proliferation of B16-BL6 cells only in the case of time incubation longer than 48 h. Quercetin dose-dependently decreased the cell rates in S and G2-M phases of cell cycle. The effect of quercetin to cause a remarkable apoptosis of B16-BL6 cells was also demonstrated by flow cytometric assay as well as DNA fragmentation with a typical 180-bp ladder band in agarose electrophoresis and a quantitative analysis. Furthermore, quercetin markedly inhibited the expression of anti-apoptotic protein Bcl-2 but hardly influenced Bcl-XL. These results suggest that the inhibition of quercetin on invasiveness and migration of B16-BL6 cells are closely associated with the arrest of cell cycle as well as the induction of apoptosis by decreasing the Bcl-2 expression.

Kolm põnevat raamatut / Kristiina Ehin

Index Scriptorium Estoniae

Ehin, Kristiina, 1977-

2003-01-01

Coelho, Paulo. Palverännak: maagi päevik : [romaan] / tõlkinud Kadre Vaik, Tiina Ristimets. [Tallinn] : Philos, 2002 ; Lescuyer, Jean ; Benchelah, Mehdi. Palverännak Jeruusalemma / prantsuse keelest tõlkinud Jaanus Õunpuu. Tallinn : Olion, 2001 ; Kureishi, Hanif. Lähedus : [romaan] / tõlkinud Aet Varik. [Tallinn] : Huma, 2002

Sugumürsust kirjanikuks

Index Scriptorium Estoniae

2003-01-01

EE kirjanduslabor võrdleb viimase aja kõmukirjanike teoseid: Verrev, Toomas. Margot : (pildikesi päälinna intelligendi elust) : [romaan. Tallinn] : Kadikas, 2003 ; Espenberg, Urmas. Tequila pööripäev: [romaan]. Tallinn : [Agitaator], 2002-2003 ; Aimre, Keith. Ilus Babyss, ehk, Seitse ja pool : [romaan]. Tallinn : Kentaur, 2003.

Eesti meesluule argipäev / Mart Velsker

Index Scriptorium Estoniae

Velsker, Mart, 1966-

2004-01-01

Rets.rmt.: Oja, Martin., keelatud raamat : tekste 1996-2000. [Tallinn] : 9 Koma, [2003] ; Ilus, Peeter. Mõned luuletused. [Tallinn : Eesti Keele Sihtasutus, 2003] ; Klaus, Eduard. Pommikutsikas : [luuletused]. Tartu : Ilmamaa, 2003 ; Mathura, pseud. Sõstramesi : luuletusi. Külaküla [p.o. Tallinn] : Erakkond, 2003 ; Runnel, Simo. Uneriik : luuletused. Tartu : Ilmamaa, 2003

Long-term artificial sweetener acesulfame potassium treatment alters neurometabolic functions in C57BL/6J mice.

Directory of Open Access Journals (Sweden)

Wei-na Cong

Full Text Available With the prevalence of obesity, artificial, non-nutritive sweeteners have been widely used as dietary supplements that provide sweet taste without excessive caloric load. In order to better understand the overall actions of artificial sweeteners, especially when they are chronically used, we investigated the peripheral and central nervous system effects of protracted exposure to a widely used artificial sweetener, acesulfame K (ACK. We found that extended ACK exposure (40 weeks in normal C57BL/6J mice demonstrated a moderate and limited influence on metabolic homeostasis, including altering fasting insulin and leptin levels, pancreatic islet size and lipid levels, without affecting insulin sensitivity and bodyweight. Interestingly, impaired cognitive memory functions (evaluated by Morris Water Maze and Novel Objective Preference tests were found in ACK-treated C57BL/6J mice, while no differences in motor function and anxiety levels were detected. The generation of an ACK-induced neurological phenotype was associated with metabolic dysregulation (glycolysis inhibition and functional ATP depletion and neurosynaptic abnormalities (dysregulation of TrkB-mediated BDNF and Akt/Erk-mediated cell growth/survival pathway in hippocampal neurons. Our data suggest that chronic use of ACK could affect cognitive functions, potentially via altering neuro-metabolic functions in male C57BL/6J mice.

Enhanced production of tetramethylpyrazine in Bacillus licheniformis BL1 by bdhA disruption and 2,3-butanediol supplementation.

Science.gov (United States)

Meng, Wu; Xiao, Dongguang; Wang, Ruiming

2016-03-01

The 2,3-butanediol (2,3-BD) dehydrogenase gene (bdhA) of Bacillus licheniformis BL1 was disrupted to construct the tetramethylpyrazine (TMP)-producing BLA strain. During microaerobic fermentation, the bdhA-disrupted BLA strain produced 46.98 g TMP/l, and this yield was 23.99% higher than that produced by the parent BL1 strain. In addition, the yield of acetoin, which is a TMP precursor, also increased by 28.98% in BLA. The TMP production by BL1 was enhanced by supplementing the fermentation medium with 2,3-BD. The yield of TMP improved from 37.89 to 44.77 g/l as the concentration of 2,3-BD increased from 0 to 2 g/l. The maximum TMP and acetoin yields increased by 18.16 and 17.87%, respectively with the increase in 2,3-BD concentration from 0 to 2 g/l. However, no increase was observed when the concentration of 2,3-BD in the matrix was ≥3 g/l. This study provides a valuable strategy to enhance TMP and acetoin productivity of mutagenic strains by gene manipulation and optimizing fermentation conditions.

Dynamical Black Hole Masses of BL Lac Objects from the Sloan Digital Sky Survey

NARCIS (Netherlands)

Plotkin, Richard M.; Markoff, Sera; Trager, Scott C.; Anderson, Scott F.

2012-01-01

We measure black hole masses for 71 BL Lac objects from the Sloan Digital Sky Survey (SDSS) with redshifts out to z ∼ 0.4. We perform spectral decompositions of their nuclei from their host galaxies and measure their stellar velocity dispersions. Black hole masses are then derived from the black

Seltskond : [fotod] / tekst ja fotod Annika Haas

Index Scriptorium Estoniae

2008-01-01

29. mail tutvustasid autorid oma lasteraamatuid Eesti Lastekirjanduse Keskuses: Kass, Kristiina. Petra lood. [Tallinn] : Tänapäev, 2008 ; Vainola, Kätlin. Mia, Konrad ja avanevad uksed : [jutustus] / pildid joonistanud Toomas Pääsuke. [Tallinn] : Tänapäev, 2008 ; Saarna, Meelike. Mattias ja mamma. [Tallinn] : Tänapäev, 2008

212ʻ Fahrenheiti : eesti luule 2006 / Piret Bristol

Index Scriptorium Estoniae

Bristol, Piret, 1968-

2008-01-01

Järgmistest 2006. a. ilmunud luulekogudest: Ryytle, Indrek. Inglid rokijaamas. Puhja : I. Rüütle ; Runnel, Hando. Viru veri ei värise. Tartu : Ilmamaa ; Vabat, Martin. Mina olengi kirjandusklassik. Tartu : Eesti Kirjanduse Selts ; Korts, Eliina. Lööklaused murravad metsi. Tartu : Eesti Kirjanduse Selts ; Koff, Indrek. Vana laul. Luige : Verb ; Teede, Andra. Takso Tallinna taevas. Luige : Verb ; Vusser, Kaspar. Vusserduste võnked. Tallinn : P. Kukk ; Elbing, Andrus. Siin Beebilõust, tere! : häired pimelinna tänavalt = Ciao, it's Babyface : trouble from the streets of a blind city. Tallinn : Epifanio ; Hint, Miina. Vabaduse vang, ehk, Põrandaalune kirjandus. Tallinn : MR ; Jüriado, Tiiu. Luule on ime. Habaja : Kentaur ; Ligi, Katre. Naabrivalve. Tartu : Ilmamaa ; Krull, Hasso. Talv. Tallinn : Tuum ; Mets, Mae. Pühapäeval on reede. Tartu : Ilmamaa ; Ploom, Ülar. Porr ja sorry. Tallinn : Tuum ; Hirv, Indrek, Surmapõletaja. Tallinn : Tuum ; Piir, Milvi Martina. Kõrkjavaas. Tartu : Fantaasia ; Soomets, Triin. Väljas. Tallinn : Tuum ; Mathura. Kohalolu. Rapla : Allikäärne ; Afanasjev, Vahur. Katedraal Emajões. Tartu ; Brüssel : ID Salong//Sild, Ivar. Spermaga ja puha. Pärnu : Jumalikud Ilmutused ; Meiel, Kaupo. Polügrafisti käsiraamat. Pärnu : Jumalikud Ilmutused ; Kivisildnik, Sven. Vägistatud jäämägi. Pärnu : Jumalikud Ilmutused ; Arder, Ott. Luule sünnib kus sünnib kui sünnib / koost. Leelo Tungal. Tallinn : Tänapäev ; Kompus, Marko. Vallaliste jõgede tõkkejooksja. Tartu : M. Kompus

Repeated Administration of D-Amphetamine Induces Distinct Alterations in Behavior and Metabolite Levels in 129Sv and Bl6 Mouse Strains

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Taavi Vanaveski

2018-06-01

Full Text Available The main goal of the study was to characterize the behavioral and metabolomic profiles of repeated administration (for 11 days of d-amphetamine (AMPH, 3 mg/kg i. p., indirect agonist of dopamine (DA, in widely used 129S6/SvEvTac (129Sv and C57BL/6NTac (Bl6 mouse strains. Acute administration of AMPH (acute AMPH induced significantly stronger motor stimulation in Bl6. However, repeated administration of AMPH (repeated AMPH caused stronger motor sensitization in 129Sv compared acute AMPH. Body weight of 129Sv was reduced after repeated saline and AMPH, whereas no change occurred in Bl6. In the metabolomic study, acute AMPH induced an elevation of isoleucine and leucine, branched chain amino acids (BCAA, whereas the level of hexoses was reduced in Bl6. Both BCAAs and hexoses remained on level of acute AMPH after repeated AMPH in Bl6. Three biogenic amines [asymmetric dimethylarginine (ADMA, alpha-aminoadipic acid (alpha-AAA, kynurenine] were significantly reduced after repeated AMPH. Acute AMPH caused in 129Sv a significant reduction of valine, lysophosphatidylcholines (lysoPC a C16:0, lysoPC a C18:2, lysoPC a C20:4, phosphatidylcholine (PC diacyls (PC aa C34:2, PC aa C36:2, PC aa C36:3, PC aa C36:4 and alkyl-acyls (PC ae C38:4, PC ae C40:4. However, repeated AMPH increased the levels of valine and isoleucine, long-chain acylcarnitines (C14, C14:1-OH, C16, C18:1, PC diacyls (PC aa C38:4, PC aa C38:6, PC aa C42:6, PC acyl-alkyls (PC ae C38:4, PC ae C40:4, PC ae C40:5, PC ae C40:6, PC ae C42:1, PC ae C42:3 and sphingolipids [SM(OHC22:1, SM C24:0] compared to acute AMPH in 129Sv. Hexoses and kynurenine were reduced after repeated AMPH compared to saline in 129Sv. The established changes probably reflect a shift in energy metabolism toward lipid molecules in 129Sv because of reduced level of hexoses. Pooled data from both strains showed that the elevation of isoleucine and leucine was a prominent biomarker of AMPH-induced behavioral sensitization

Sub-Hour X-Ray Variability of High-Energy Peaked BL Lacertae Objects

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Bidzina Kapanadze

2018-03-01

Full Text Available The study of multi-wavelength flux variability in BL Lacertae objects is very important to discern unstable processes and emission mechanisms underlying their extreme observational features. While the innermost regions of these objects are not accessible from direct observations, we may draw conclusions about their internal structure via the detection of flux variations on various timescales, based on the light-travel argument. In this paper, we review the sub-hour X-ray variability in high-energy peaked BL Lacertae sources (HBLs that are bright at X-rays and provide us with an effective tool to study the details related to the physics of the emitting particles. The X-ray emission of these sources is widely accepted to be a synchrotron radiation from the highest-energy electrons, and the complex spectral variability observed in this band reflects the injection and radiative evolution of freshly-accelerated particles. The detection of sub-hour X-ray flux variability is very important since it can be related to the small-scale jet turbulent structures or triggered by unstable processes occurring in the vicinity of a central supermassive black hole. We summarize the fastest X-ray variability instances detected in bright HBLs and discuss their physical implications.

Effects of genistein, a soybean-derived isoflavone, on proliferation and differentiation of B16-BL6 mouse melanoma cells.

Science.gov (United States)

Yan, C H; Chen, X G; Li, Y; Han, R

1999-01-01

Genistein, a soybean-derived isoflavone, may contribute to the lower cancer incidence in South Asian countries. In this study, the effects and molecular mechanisms of genistein on growth and differentiation of B16-BL6 mouse melanoma cells were investigated. Genistein suppressed the growth of these melanoma cells. The IC50 value is 15.5 microM. On the other hand, genistein induced the changes of cell shape and cytoskeletal network. The cytoskeletal filaments were induced to form a bundle along the direction of elongation of the cells. Moreover, tyrosine phosphorylation levels of cytoskeleton-associated proteins decreased after the cells were exposed to 20 or 30 microM of genistein for 3 days. All these morphological and molecular changes were accompanied by appearance of the differentiated phenotypes. Genistein induced the increase of cellular melanin content, enhancement of tyrosinase activity, and decrease of colonization potentials in soft agar in a time-dependent and dose-dependent manner. The effective concentration was no more than 10 microM after 3 days' exposure. The tumorigenic potentials of B16-BL6 cells in C57BL/6 mouse also decreased after exposure to 20 or 30 microM of genistein for 3 days. When expressions of tumor-related genes were investigated in the differentiation-induced cells, the content of P53 dramatically increased while that of c-Myc protein decreased. Therefore, due to its ability to induce cellular and molecular changes, genistein suppressed the growth and induced differentiated phenotypes in B16-BL6 melanoma cells.

Contribution of sortase SrtA2 to Lactobacillus casei BL23 inhibition of Staphylococcus aureus internalization into bovine mammary epithelial cells.

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Renata F S Souza

Full Text Available Probiotics have been considered as a promising strategy to prevent various diseases in both humans and animals. This approach has gained interest in recent years as a potential means to control bovine mastitis. In a previous study, we found that several L. casei strains, including BL23, were able to inhibit the internalization of S. aureus, a major etiologic agent of mastitis, into bovine mammary epithelial cells (bMEC. This antagonism required a direct contact between L. casei and bMEC or S. aureus, suggesting the inhibition relied on interactions between L. casei cell surface components and bMEC. In this study, we have investigated the impact of some candidates which likely influence bacteria host cell interactions. We have shown that L. casei BL23 fbpA retained its inhibitory potential, indicating that L. casei BL23 antagonism did not rely (solely on competition between S. aureus and L. casei fibronectin-binding proteins for adhesion to bMEC. We have then investigated the impact of four sortase mutants, srtA1, srtA2, srtC1 and srtC2, and a double mutant (srtA1-srtA2 on L. casei BL23 inhibitory potential. Sortases are responsible for the anchoring on the bacterial cell wall of LPXTG-proteins, which reportedly play an important role in bacteria-host cell interaction. All the srt mutants tested presented a reduced inhibition capacity, the most pronounced effect being observed with the srtA2 mutant. A lower internalization capacity of L. casei srtA2 into bMEC was also observed. This was associated with several changes at the surface of L. casei BL23 srtA2 compared to the wild type (wt strain, including altered abundance of some LPXTG- and moonlighting proteins, and modifications of cell wall structure. These results strongly support the role of sortase A2 in L. casei BL23 inhibition against S. aureus internalization. Deciphering the contribution of the cell surface components altered in srtA2 strain in the inhibition will require further

THE PHYSICAL CHARACTERIZATION OF THE POTENTIALLY HAZARDOUS ASTEROID 2004 BL86: A FRAGMENT OF A DIFFERENTIATED ASTEROID

Energy Technology Data Exchange (ETDEWEB)

Reddy, Vishnu; Sanchez, Juan A.; Takir, Driss; Corre, Lucille Le [Planetary Science Institute, 1700 East Fort Lowell Road, Tucson, AZ 85719 (United States); Gary, Bruce L. [Hereford Arizona Observatory, Hereford, AZ 85615 (United States); Thomas, Cristina A. [NASA Goddard Spaceflight Center, Greenbelt, MD 20771 (United States); Hardersen, Paul S. [Department of Space Studies, University of North Dakota, Grand Forks, ND 58202 (United States); Ogmen, Yenal [Green Island Observatory, Geçitkale, Maǧusa, via Mersin 10  North Cyprus (Turkey); Benni, Paul [Acton Sky Portal, 3 Concetta Circle, Acton, MA 01720 (United States); Kaye, Thomas G. [Raemor Vista Observatory, Sierra Vista, AZ 85650 (United States); Gregorio, Joao [Atalaia Group, Crow Observatory (Portalegre) Travessa da Cidreira, 2 rc D, 2645-039 Alcabideche (Portugal); Garlitz, Joe [1155 Hartford Street, Elgin, OR 97827 (United States); Polishook, David [Weizmann Institute of Science, Herzl Street 234, Rehovot, 7610001 (Israel); Nathues, Andreas, E-mail: reddy@psi.edu [Max-Planck Institute for Solar System Research, Justus-von-Liebig-Weg 3, D-37077 Göttingen (Germany)

2015-09-20

The physical characterization of potentially hazardous asteroids (PHAs) is important for impact hazard assessment and evaluating mitigation options. Close flybys of PHAs provide an opportunity to study their surface photometric and spectral properties that enable the identification of their source regions in the main asteroid belt. We observed PHA (357439) 2004 BL86 during a close flyby of the Earth at a distance of 1.2 million km (0.0080 AU) on 2015 January 26, with an array of ground-based telescopes to constrain its photometric and spectral properties. Lightcurve observations showed that the asteroid was a binary and subsequent radar observations confirmed the binary nature and gave a primary diameter of 300 m and a secondary diameter of 50–100 m. Our photometric observations were used to derive the phase curve of 2004 BL86 in the V-band. Two different photometric functions were fitted to this phase curve, the IAU H–G model and the Shevchenko model. From the fit of the H–G function we obtained an absolute magnitude of H = 19.51 ± 0.02 and a slope parameter of G = 0.34 ± 0.02. The Shevchenko function yielded an absolute magnitude of H = 19.03 ± 0.07 and a phase coefficient b = 0.0225 ± 0.0006. The phase coefficient was used to calculate the geometric albedo (Ag) using the relationship found by Belskaya and Schevchenko, obtaining a value of Ag = 40% ± 8% in the V-band. With the geometric albedo and the absolute magnitudes derived from the H–G and the Shevchenko functions we calculated the diameter (D) of 2004 BL86, obtaining D = 263 ± 26 and D = 328 ± 35 m, respectively. 2004 BL86 spectral band parameters and pyroxene chemistry are consistent with non-cumulate eucrite meteorites. A majority of these meteorites are derived from Vesta and are analogous with surface lava flows on a differentiated parent body. A non-diagnostic spectral curve match using the Modeling for Asteroids tool yielded a best-match with non-cumulate eucrite Bereba. Three other

Differences in the degree of cerulein-induced chronic pancreatitis in C57BL/6 mouse substrains lead to new insights in identification of potential risk factors in the development of chronic pancreatitis.

Science.gov (United States)

Ulmasov, Barbara; Oshima, Kiyoko; Rodriguez, Michael G; Cox, Roger D; Neuschwander-Tetri, Brent A

2013-09-01

A frequently used experimental model of chronic pancreatitis (CP) recapitulating human disease is repeated injection of cerulein into mice. C57BL/6 is the most commonly used inbred mouse strain for biomedical research, but widespread demand has led to generation of several substrains with subtly different phenotypes. In this study, two common substrains, C57BL/6J and C57BL/6NHsd, exhibited different degrees of CP, with C57BL/6J being more susceptible to repetitive cerulein-induced CP as assessed by pancreatic atrophy, pancreatic morphological changes, and fibrosis. We hypothesized that the deficiency of nicotinamide nucleotide transhydrogenase (NNT) protein in C57BL/6J is responsible for the more severe C57BL/6J phenotype but the parameters of CP in NNT-expressing transgenic mice generated on a C57BL6/J background do not differ with those of wild-type C57BL/6J. The highly similar genetic backgrounds but different CP phenotypes of these two substrains presents a unique opportunity to discover genes important in pathogenesis of CP. We therefore performed whole mouse genome Affymetrix microarray analysis of pancreatic gene expression of C57BL/6J and C57BL/6NHsd before and after induction of CP. Genes with differentially regulated expression between the two substrains that might be candidates in CP progression included Mmp7, Pcolce2, Itih4, Wdfy1, and Vtn. We also identified several genes associated with development of CP in both substrains, including RIKEN cDNA 1810009J06 gene (trypsinogen 5), Ccl8, and Ccl6. Copyright © 2013 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

Hüdra aastasada / Ene-Reet Soovik

Index Scriptorium Estoniae

Soovik, Ene-Reet

1997-01-01

Arvustus: Galsworthy, John. Peatüki lõpp : Üle jõe / tlk. Jüri ja Liisi Ojamaa. Tallinn : Eesti Raamat, 1997; Amis, Kingsley. qnneseen Jim / tlk. Urve Hanko. Tallinn : Eesti Raadio, 1997; Boyd, William. Sinine pärastlõuna / tlk. Virve Krimm. Tallinn : Varrak, 1997. Briti XX saj. kirjanduse ülevaade

Corticosterone facilitates extinction of fear memory in BALB/c mice but strengthens cue related fear in C57BL/6 mice.

Science.gov (United States)

Brinks, V; de Kloet, E R; Oitzl, M S

2009-04-01

Corticosterone, the naturally occurring glucocorticoid of rodents is secreted in response to stressors and is known for its facilitating and detrimental effects on emotional learning and memory. The large variability in the action of corticosterone on processing of emotional memories is postulated to depend on genetic background and the spatio-temporal domain in which the hormone operates. To address this hypothesis, mice of two strains with distinct corticosterone secretory patterns and behavioural phenotype (BALB/c and C57BL/6J) were treated with corticosterone (250 microg/kg, i.p.), either 5 min before or directly after acquisition in a fear conditioning task. As the paradigm allowed assessing in one experimental procedure both context- and cue-related fear behaviour, we were able to detect generalization and specificity of fear. BALB/c showed generalized strong fear memory, while C57BL/6J mice discriminated between freezing during context- and cue episodes. Corticosterone had opposite effects on fear memory depending on the strain and time of injection. Corticosterone after acquisition did not affect C57BL/6J mice, but destabilized consolidation and facilitated extinction in BALB/c. Corticosterone 5 min before acquisition strengthened stress-associated signals: BALB/c no longer showed lower fear memory, while C57BL/6J mice displayed increased fear memory and impaired extinction in cue episodes. We propose that corticosterone-induced facilitation of fear memory in C57BL/6J mice can be used to study the development of fear memories, corticosterone administration in BALB/c mice presents a model to examine treatment. We conclude that genetic background and time of corticosterone action are modifiers of fear memory with interesting translational implications for anxiety-related diseases.

Differential effects of age on circulating and splenic leukocyte populations in C57BL/6 and BALB/c male mice

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Filipov Nikolay M

2008-02-01

Full Text Available Abstract Background Despite several reports on age-related phenotypic changes of the immune system's cells, studies that use a multipoint age comparison between the specific and innate immune cell populations of prototypical Th1- and Th2-type polarized mouse strains are still lacking. Results Using a multipoint age comparison approach, cells from the two major immune system compartments, peripheral blood and spleen, and flow cytometry analysis, we found several principal differences in T cell and professional antigen presenting cell (APC populations originating from a prototypical T helper (Th 1 mouse strain, C57BL/6, and a prototypical Th2 strain, BALB/c. For example, regardless of age, there were strain differences in both peripheral blood mononuclear cells (PBMC and spleens in the proportion of CD4+ (higher in the BALB/c strain, CD8+ T cells and CD11b+/CD11c+ APC (greater in C57BL/6 mice. Other differences were present only in PBMC (MHC class II + and CD19+ were greater in C57BL/6 mice or differences were evident in the spleens but not in circulation (CD3+ T cells were greater in C57BL/6 mice. There were populations of cells that increased with age in PBMC and spleens of both strains (MHC class II+, decreased in the periphery and spleens of both strains (CD11b+ or did not change in the PBMC and spleens of both strains (CD8+. We also found strain and age differences in the distribution of naïve and memory/activated splenic T cells, e.g., BALB/c mice had more memory/activated and less naive CD8+ and CD4+ T cells and the C57BL/6 mice. Conclusion Our data provide important information on the principal differences, within the context of age, in T cell and professional APC populations between the prototypical Th1 mouse strain C57BL/6 and the prototypical Th2 strain BALB/c. Although the age-related changes that occur may be rather subtle, they may be very relevant in conditions of disease and stress. Importantly, our data indicate that age and

Kolmanda raamatu kiituseks / Peeter Olesk

Index Scriptorium Estoniae

Olesk, Peeter, 1953-

2009-01-01

Tutvustus: Isaacson, Walter. Einstein : tema elu ja universum / tõlkinud Matti Piirimaa. Tallinn : Eesti Raamat, 2009; Fortey, Jacqueline. Kuulsad teadlased (Silmaring) / tõlkinud Ülle Haav ja Helen Haav. Tallinn : Koolibri, 2009; Vaim ja aeg (Lehed ja tähed : looduse ja teaduse aastaraamat, 5) / koostanud Indrek Rohtmets ja Toomas Kukk. Tallinn : Loodusajakiri, 2009

Tõde jälitab meid kui vari / Vaapo Vaher

Index Scriptorium Estoniae

Vaher, Vaapo, 1945-

2006-01-01

Erich Maria Remarque'ist seoses romaani "Lissaboni öö" kordustrüki ilmumisega (kirj. Tänapäev). Raamatututvustused: Vaarandi, Debora. Aastad ja päevad : nooruselugu. Tallinn : Tänapäev, 2006 ; Loosaar, Evald. Eesti mehe lugu. Tallinn : Varrak, 2006 ; Kangro, Bernard, Ristikivi, Karl. Kirjad romaanist : 31 kirja aastaist 1966-1977. Tallinn : Varrak, 2006

Short Outlines of Books by Estonian Authors / Janika Kronberg, Rutt Hinrikus

Index Scriptorium Estoniae

Kronberg, Janika, 1963-

2009-01-01

Arvustus: Kaplinski, Jaan. Parallelle ja parallelisme. Tartu : Tartu Ülikooli Kirjastus, c2009 ; Hellat, Henn-Kaarel. Inimese tegemine I-V. Tallinn : Faatum, 2002-2008 ; Nõu, Helga. Elu täis üllatusi. Tartu : Atlex, 2009 ; Remsu, Olev. Musketäride muundumised. [Tallinn] : Eesti Keele Sihtasutus, 2008 ; Ristikivi, Karl. Päevaraamat 1957-1968. Tallinn : Varrak, 2008

Küülikud jooksus ja jumal surnud : eesti lasteproosa tipud on "kuldaja" autoritega võrdväärsed / Jürgen Rooste

Index Scriptorium Estoniae

Rooste, Jürgen, 1979-

2005-01-01

Arvustus: Raud, Piret. Ernesto küülikud. Tallinn : Tänapäev, 2004 ; Soans, Kerttu. Kruubi-Ruudi ja tema inimesed. Puhja : Väike Vanker, 2004 ; Kivirähk, Andrus. Limpa ja mereröövlid. Tallinn : Varrak, 2004 ; Sauter, Peeter. Laste raamat / Rull ja Ekke ja Pipa ja Peeter Sauter. Tallinn : Huma, 2004

Raamat / Matis Rodin

Index Scriptorium Estoniae

Rodin, Matis

2012-01-01

Raamatututvustus: Paulus, Karin. Tootedisain : asjad minu elus. Tallinn : Eesti Kunstiakadeemia, 2011; Vainküla, Tõnu, Pere, René. Vana mööbel korda oma kätega. [Tallinn] : Ajakirjade Kirjastus, 2012; Ruumipilt 2011 : Eesti parimad interjöörid ja disain / Eesti Sisearhitektide Liit ; toimetaja ja vastutav väljaandja Priit Põldme. Tallinn, 2012

Enhanced glucose tolerance in pancreatic-derived factor (PANDER knockout C57BL/6 mice

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Shari L. Moak

2014-11-01

Full Text Available Pancreatic-derived factor (PANDER; also known as FAM3B is a uniquely structured protein strongly expressed within and secreted from the endocrine pancreas. PANDER has been hypothesized to regulate fasting and fed glucose homeostasis, hepatic lipogenesis and insulin signaling, and to serve a potential role in the onset or progression of type 2 diabetes (T2D. Despite having potentially pivotal pleiotropic roles in glycemic regulation and T2D, there has been limited generation of stable animal models for the investigation of PANDER function, and there are no models on well-established genetic murine backgrounds for T2D. Our aim was to generate an enhanced murine model to further elucidate the biological function of PANDER. Therefore, a pure-bred PANDER knockout C57BL/6 (PANKO-C57 model was created and phenotypically characterized with respect to glycemic regulation and hepatic insulin signaling. The PANKO-C57 model exhibited an enhanced metabolic phenotype, particularly with regard to enhanced glucose tolerance. Male PANKO-C57 mice displayed decreased fasting plasma insulin and C-peptide levels, whereas leptin levels were increased as compared with matched C57BL/6J wild-type mice. Despite similar peripheral insulin sensitivity between both groups, hepatic insulin signaling was significantly increased during fasting conditions, as demonstrated by increased phosphorylation of hepatic PKB/Akt and AMPK, along with mature SREBP-1 expression. Insulin stimulation of PANKO-C57 mice resulted in increased hepatic triglyceride and glycogen content as compared with wild-type C57BL/6 mice. In summary, the PANKO-C57 mouse represents a suitable model for the investigation of PANDER in multiple metabolic states and provides an additional tool to elucidate the biological function and potential role in T2D.

KEEFEKTIFAN MODEL PjBL DENGAN TUGAS CREATIVE MIND-MAP UNTUK MENINGKATKAN KONEKSI MATEMATIK SISWA

Directory of Open Access Journals (Sweden)

Zulfa Ainurrizqiyah

2015-08-01

Full Text Available Tujuan  penelitian ini adalah untuk mengetahui  peningkatan kemampuan koneksi matematik, apakah terdapat perbedaan serta manakah yang lebih baik antara pembelajaran dengan model PjBL dengan tugas creative mind-map dan pembelajaran ekspositori pada siswa kelas X materi Trigonometri. Penelitian eksperimen yang dilakukan dengan pre and posttest control group design ini memiliki populasi yakni siswa kelas X SMAN 1 Sukorejo tahun ajaran 2014/2015. Dengan menggunakan cluster random sampling, terpilih sampel yaitu siswa kelas XB sebagai kelas kontrol dengan pembelajaran ekspositori dan XC sebagai kelas eksperimen dengan model PjBL dengan tugas creative mind-map. Data kemampuan koneksi matematik dianalisis menggunakan uji proporsi, uji beda rata-rata. Berdasarkan uji proporsi, diperoleh lebih dari 75 % siswa kelas eksperimen mencapai nilai ketuntasan belajar, yaitu 75. Selain itu, diperoleh adanya perbedaan hasil kemampuan koneksi matematik antar kedua kelas dimana kelas eksperimen lebih baik daripada siswa kelas kontrol. Sedangkan untuk peningkatan menggunakan uji t berpasangan dan gain ternormalisasi dengan hasilnya yaitu terdapat peningkatan kemampuan koneksi matematik pada kelas eksperimen dengan kriteria tinggi.

Respiratory syncytial virus increases lung cellular bioenergetics in neonatal C57BL/6 mice

International Nuclear Information System (INIS)

Alsuwaidi, Ahmed R.; Albawardi, Alia; Almarzooqi, Saeeda; Benedict, Sheela; Othman, Aws R.; Hartwig, Stacey M.; Varga, Steven M.; Souid, Abdul-Kader

2014-01-01

We have previously reported that lung cellular bioenergetics (cellular respiration and ATP) increased in 4–10 week-old BALB/c mice infected with respiratory syncytial virus (RSV). This study examined the kinetics and changes in cellular bioenergetics in ≤2-week-old C57BL/6 mice following RSV infection. Mice (5–14 days old) were inoculated intranasally with RSV and the lungs were examined on days 1–10 post-infection. Histopathology and electron microscopy revealed preserved pneumocyte architectures and organelles. Increased lung cellular bioenergetics was noted from days 1–10 post-infection. Cellular GSH remained unchanged. These results indicate that the increased lung cellular respiration (measured by mitochondrial O 2 consumption) and ATP following RSV infection is independent of either age or genetic background of the host. - Highlights: • RSV infection increases lung cellular respiration and ATP in neonatal C57BL/6 mice. • Increased lung cellular bioenergetics is a biomarker of RSV infection. • Lung cellular glutathione remains unchanged in RSV infection

Respiratory syncytial virus increases lung cellular bioenergetics in neonatal C57BL/6 mice

Energy Technology Data Exchange (ETDEWEB)

Alsuwaidi, Ahmed R., E-mail: alsuwaidia@uaeu.ac.ae [Departments of Pediatrics, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain (United Arab Emirates); Albawardi, Alia, E-mail: alia.albawardi@uaeu.ac.ae [Departments of Pathology, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain (United Arab Emirates); Almarzooqi, Saeeda, E-mail: saeeda.almarzooqi@uaeu.ac.ae [Departments of Pathology, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain (United Arab Emirates); Benedict, Sheela, E-mail: sheela.benedict@uaeu.ac.ae [Departments of Pediatrics, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain (United Arab Emirates); Othman, Aws R., E-mail: aws.rashad@uaeu.ac.ae [Departments of Pediatrics, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain (United Arab Emirates); Hartwig, Stacey M., E-mail: stacey-hartwig@uiowa.edu [Department of Microbiology, Department of Pathology and Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242 (United States); Varga, Steven M., E-mail: steven-varga@uiowa.edu [Department of Microbiology, Department of Pathology and Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242 (United States); Souid, Abdul-Kader, E-mail: asouid@uaeu.ac.ae [Departments of Pediatrics, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain (United Arab Emirates)

2014-04-15

We have previously reported that lung cellular bioenergetics (cellular respiration and ATP) increased in 4–10 week-old BALB/c mice infected with respiratory syncytial virus (RSV). This study examined the kinetics and changes in cellular bioenergetics in ≤2-week-old C57BL/6 mice following RSV infection. Mice (5–14 days old) were inoculated intranasally with RSV and the lungs were examined on days 1–10 post-infection. Histopathology and electron microscopy revealed preserved pneumocyte architectures and organelles. Increased lung cellular bioenergetics was noted from days 1–10 post-infection. Cellular GSH remained unchanged. These results indicate that the increased lung cellular respiration (measured by mitochondrial O{sub 2} consumption) and ATP following RSV infection is independent of either age or genetic background of the host. - Highlights: • RSV infection increases lung cellular respiration and ATP in neonatal C57BL/6 mice. • Increased lung cellular bioenergetics is a biomarker of RSV infection. • Lung cellular glutathione remains unchanged in RSV infection.

Complete Genome Sequence of the Aerobic Facultative Methanotroph Methylocella silvestris BL2▿

Science.gov (United States)

Chen, Yin; Crombie, Andrew; Rahman, M. Tanvir; Dedysh, Svetlana N.; Liesack, Werner; Stott, Matthew B.; Alam, Maqsudul; Theisen, Andreas R.; Murrell, J. Colin; Dunfield, Peter F.

2010-01-01

Methylocella silvestris BL2 is an aerobic methanotroph originally isolated from an acidic forest soil in Germany. It is the first fully authenticated facultative methanotroph. It grows not only on methane and other one-carbon (C1) substrates, but also on some compounds containing carbon-carbon bonds, such as acetate, pyruvate, propane, and succinate. Here we report the full genome sequence of this bacterium. PMID:20472789

Complete Genome Sequence of the Aerobic Facultative Methanotroph Methylocella silvestris BL2▿

OpenAIRE

Chen, Yin; Crombie, Andrew; Rahman, M. Tanvir; Dedysh, Svetlana N.; Liesack, Werner; Stott, Matthew B.; Alam, Maqsudul; Theisen, Andreas R.; Murrell, J. Colin; Dunfield, Peter F.

2010-01-01

Methylocella silvestris BL2 is an aerobic methanotroph originally isolated from an acidic forest soil in Germany. It is the first fully authenticated facultative methanotroph. It grows not only on methane and other one-carbon (C1) substrates, but also on some compounds containing carbon-carbon bonds, such as acetate, pyruvate, propane, and succinate. Here we report the full genome sequence of this bacterium.

Expression, purification, crystallization and preliminary X-ray analysis of the human RuvB-like protein RuvBL1

International Nuclear Information System (INIS)

Gorynia, Sabine; Matias, Pedro M.; Gonçalves, Susana; Coelho, Ricardo; Lopes, Gonçalo; Thomaz, Mónica; Huber, Martina; Haendler, Bernard; Donner, Peter; Carrondo, Maria Arménia

2005-01-01

Human RuvB-like protein RuvBL1 plays important roles in essential signaling pathways like c-Myc and Wnt, in transcription, and in DNA repair and apoptosis. Crystals of both native and a Se-Met derivative were obtained and characterized. SAD data leading to the structure solution at 2.2 Å were measured from the Se-Met crystals. RuvBL1, an evolutionary highly conserved protein related to the AAA + family of ATPases, has been crystallized using the hanging-drop vapour-diffusion method at 293 K. The crystals are hexagonal and belong to space group P6, with unit-cell parameters a = b = 207.1, c = 60.7 Å and three molecules in the asymmetric unit

Moodsa luule maailmakeel / Märt Väljataga

Index Scriptorium Estoniae

Väljataga, Märt, 1965-

2007-01-01

Magrelli, Valerio. Luule DNA = Il DNE della poesia / tõlkinudk Maarja Kangro ja Kalju Kruusa. Tallinn : Koma, 2006 ; Enzensberger, Hans. Tõmba sobimatu maha : [luuletused] / saksa keelest tõlkinud [ja järelsõna:] Maarja Kangro. Tallinn : Kultuurileht, 2006 ; Kronbergs, Juris. Maa-alune luule / läti keelest tõlkinud Guntars Godinsh, Livia Viitol. Tallinn : Kultuurileht, 2007

Emotion and cognition in high and low stress sensitive mouse strains: a combined neuroendocrine and behavioral study in BALB/c and C57BL/6J mice

Directory of Open Access Journals (Sweden)

Vera Brinks

2007-12-01

Full Text Available Emotionally arousing experiences and stress influence cognitive processes and vice versa. Understanding the relations and interactions between these three systems forms the core of this study. We tested two inbred mouse strains (BALB/c, C57BL/6J; male; 3-month-old for glucocorticoid stress system markers (expression of MR and GR mRNA and protein in hippocampus, amygdala, and prefrontal cortex; blood plasma corticosterone, used behavioral tasks for emotions and cognitive performance (elevated plus maze, holeboard to assess the interdependence of these factors. We hypothesize that BALB/c mice have a stress-vulnerable neuroendocrine phenotype and that emotional expressions in BALB/c and C57BL/6J mice will differentially contribute to learning and memory. We applied factor analyses on emotional and cognitive parameters to determine the behavioral structure of BALB/c and C57BL/6J mice. Glucocorticoid stress system markers indeed show that BALB/c mice are more stress-vulnerable than C57BL/6J mice. Moreover, emotional and explorative factors differed between naïve BALB/c and C57BL/6J mice. BALB/c mice display high movement in anxiogenic zones and high risk assessment, while C57BL/6J mice show little movement in anxiogenic zones and display high vertical exploration. Furthermore, BALB/c mice are superior learners, showing learning related behavior which is highly structured and emotionally biased when exposed to a novel or changing situation. In contrast, C57BL/6J mice display a rather ‘‘chaotic’’ behavioral structure during learning in absence of an emotional factor. These results show that stress vulnerability coincides with more emotionality, which drives well orchestrated goal directed behavior to the benefit of cognition. Both phenotypes have their advantage depending on environmental demands.

Ionization and NO production in the polar mesosphere during high-speed solar wind streams. Model validation and comparison with NO enhancements observed by Odin-SMR

Energy Technology Data Exchange (ETDEWEB)

Kirkwood, S.; Belova, E. [Swedish Institute of Space Physics, Kiruna (Sweden). Polar Atmospheric Research; Osepian, A. [Polar Geophysical Institute, Murmansk (Russian Federation); Urban, J.; Perot, K. [Chalmers Univ. of Technology, Gothenburg (Sweden). Dept. of Radio and Space Science; Sinha, A.K. [Indian Institute of Geomagnetism, Navi Mumbai (India)

2015-09-01

Precipitation of high-energy electrons (EEP) into the polar middle atmosphere is a potential source of significant production of odd nitrogen, which may play a role in stratospheric ozone destruction and in perturbing large-scale atmospheric circulation patterns. High-speed streams of solar wind (HSS) are a major source of energization and precipitation of electrons from the Earth's radiation belts, but it remains to be determined whether these electrons make a significant contribution to the odd-nitrogen budget in the middle atmosphere when compared to production by solar protons or by lower-energy (auroral) electrons at higher altitudes, with subsequent downward transport. Satellite observations of EEP are available, but their accuracy is not well established. Studies of the ionization of the atmosphere in response to EEP, in terms of cosmic-noise absorption (CNA), have indicated an unexplained seasonal variation in HSS-related effects and have suggested possible order-of-magnitude underestimates of the EEP fluxes by the satellite observations in some circumstances. Here we use a model of ionization by EEP coupled with an ion chemistry model to show that published average EEP fluxes, during HSS events, from satellite measurements (Meredith et al., 2011), are fully consistent with the published average CNA response (Kavanagh et al., 2012). The seasonal variation of CNA response can be explained by ion chemistry with no need for any seasonal variation in EEP. Average EEP fluxes are used to estimate production rate profiles of nitric oxide between 60 and 100 km heights over Antarctica for a series of unusually well separated HSS events in austral winter 2010. These are compared to observations of changes in nitric oxide during the events, made by the sub-millimetre microwave radiometer on the Odin spacecraft. The observations show strong increases of nitric oxide amounts between 75 and 90 km heights, at all latitudes poleward of 60 S, about 10 days after the

Ionization and NO production in the polar mesosphere during high-speed solar wind streams. Model validation and comparison with NO enhancements observed by Odin-SMR

International Nuclear Information System (INIS)

Kirkwood, S.; Belova, E.; Urban, J.; Perot, K.

2015-01-01

Precipitation of high-energy electrons (EEP) into the polar middle atmosphere is a potential source of significant production of odd nitrogen, which may play a role in stratospheric ozone destruction and in perturbing large-scale atmospheric circulation patterns. High-speed streams of solar wind (HSS) are a major source of energization and precipitation of electrons from the Earth's radiation belts, but it remains to be determined whether these electrons make a significant contribution to the odd-nitrogen budget in the middle atmosphere when compared to production by solar protons or by lower-energy (auroral) electrons at higher altitudes, with subsequent downward transport. Satellite observations of EEP are available, but their accuracy is not well established. Studies of the ionization of the atmosphere in response to EEP, in terms of cosmic-noise absorption (CNA), have indicated an unexplained seasonal variation in HSS-related effects and have suggested possible order-of-magnitude underestimates of the EEP fluxes by the satellite observations in some circumstances. Here we use a model of ionization by EEP coupled with an ion chemistry model to show that published average EEP fluxes, during HSS events, from satellite measurements (Meredith et al., 2011), are fully consistent with the published average CNA response (Kavanagh et al., 2012). The seasonal variation of CNA response can be explained by ion chemistry with no need for any seasonal variation in EEP. Average EEP fluxes are used to estimate production rate profiles of nitric oxide between 60 and 100 km heights over Antarctica for a series of unusually well separated HSS events in austral winter 2010. These are compared to observations of changes in nitric oxide during the events, made by the sub-millimetre microwave radiometer on the Odin spacecraft. The observations show strong increases of nitric oxide amounts between 75 and 90 km heights, at all latitudes poleward of 60 S, about 10 days after the

Sub-Hour X-Ray Variability of High-Energy Peaked BL Lacertae Objects

OpenAIRE

Bidzina Kapanadze

2018-01-01

The study of multi-wavelength flux variability in BL Lacertae objects is very important to discern unstable processes and emission mechanisms underlying their extreme observational features. While the innermost regions of these objects are not accessible from direct observations, we may draw conclusions about their internal structure via the detection of flux variations on various timescales, based on the light-travel argument. In this paper, we review the sub-hour X-ray variability in high-e...

The NuSTAR view on Hard-TeV BL Lacs

Science.gov (United States)

Costamante, L.; Bonnoli, G.; Tavecchio, F.; Ghisellini, G.; Tagliaferri, G.; Khangulyan, D.

2018-05-01

Hard-TeV BL Lacs are a new type of blazars characterized by a hard intrinsic TeV spectrum, locating the peak of their gamma-ray emission in the spectral energy distribution (SED) above 2-10 TeV. Such high energies are problematic for the Compton emission, using a standard one-zone leptonic model. We study six examples of this new type of BL Lacs in the hard X-ray band with NuSTAR. Together with simultaneous observations with the Neil Gehrels Swift Observatory, we fully constrain the peak of the synchrotron emission in their SED, and test the leptonic synchrotron self-Compton (SSC) model. We confirm the extreme nature of 5 objects also in the synchrotron emission. We do not find evidence of additional emission components in the hard X-ray band. We find that a one-zone SSC model can in principle reproduce the extreme properties of both peaks in the SED, from X-ray up to TeV energies, but at the cost of i) extreme electron energies with very low radiative efficiency, ii) conditions heavily out of equipartition (by 3 to 5 orders of magnitude), and iii) not accounting for the simultaneous UV data, which then should belong to a different emission component, possibly the same as the far-IR (WISE) data. We find evidence of this separation of the UV and X-ray emission in at least two objects. In any case, the TeV electrons must not "see" the UV or lower-energy photons, even if coming from different zones/populations, or the increased radiative cooling would steepen the VHE spectrum.

[Nomenclature of Feiyang (BL 58) and its connotation exploration based on A-B Classic of Acupuncture and Moxibustion].

Science.gov (United States)

Feng, Shuangshuang; Hou, Zhongwei

2018-04-12

A - B Classic of Acupuncture and Moxibustion ( Zhen Jiu Jia Yi Jing ) is the earliest and existed well-known work on acupuncture and moxibustion, with irreplaceable literature values and huge impacts on the later generations. Feiyang (BL 58) is the luo -connecting point of the bladder meridian and recorded 11 times in A - B Classic of Acupuncture and Moxibustion . This book is the representative for the exploration on the acupoint nomenclature and clinical connotation. Through the investigation on the textual connotation of the specified terms and the alias of Feiyang (BL 58), it was discovered that the nomenclature of this acupoint was based on the main symptoms, the characters of the running course of meridian and acupuncture effects. It was proved that the unique property of this acupoint was as rising, dispersing and flying of meridian qi . In comparison of Huangdi Three - Version of A - B Classic of Acupuncture and Moxibustion ( Huangdi Sanbu Zhen Jiu Jia Yi Jing ) of the printed edition of the Song Dynasty version and Meridian - Collateral and Acupoints ( Zhen Jiu Shu Xue Xue ), it was found that the indications and connotation of Feiyang (BL 58) were more extensively richer than the records in teaching materials. Those study results contribute to the extension of the clinical application of this acupoint.

Kirjanik ja pasatornaado I / Tiit Aleksejev

Index Scriptorium Estoniae

Aleksejev, Tiit, 1968-

2008-01-01

Vene kodusõja kajastamisest 1920. aastate nõukogude proosas. Käsitletakse Isaak Babeli novellikogu "Ratsaarmee" (tõlkinud Olev Jõgi. Tallinn : Eesti Raamat, 1977), Boriss Lavrenjovi jutustust "Neljakümne esimene" (tõlkinud Jüri Karindi. Tallinn : Eesti Raamat, 1975), Viktor Kini jutustust "Valgete tagalas" (tõlkinud Jüri Ojamaa. Tallinn : Eesti Raamat, 1978), Hubert Minagrelli jutustust "Neli sõdurit" (pr. k. "Quatre soldats"), Andrei Platonovi novelli "Inimene iseendas" (ilmunud raamatus "Meistri saamine" / tõlkinud Virve Krimm. Tallinn : Eesti Raamat, 1979) ja romaani "Tševengur" (ilmunud raamatus "Tševengur. Kotlovan. Rasskazõ". Moskva, 2007), samuti ka Arkadi Gaidari loomingut

Soft x-ray beamline BL7A at the UVSOR

International Nuclear Information System (INIS)

Murata, T.; Matsukawa, T.; Naoe, S.; Horigome, T.; Matsudo, O.; Watanabe, M.

1992-01-01

A vacuum-compatible double-crystal monochromator with constant exit-beam height has been installed and operated for several years at beamline BL7A at the UVSOR facility at the Institute for Molecular Science, Okazaki, Japan, The beamline is used both for the photons from a normal bending-magnet section and those from a 4 T superconducting three-pole horizontal wiggler. Various pairs of monochromator crystals are being used with sufficient intensity and signal to noise ratio of the output signal. Basic structure of the beamline, the mechanism of the monochromator, and some typical spectra of materials with absorption edges between 850 eV and 4 keV are reported

Alcohol consumption suppresses metastasis of B16-BL6 melanoma in mice.

Science.gov (United States)

Meadows, G G; Elstad, C A; Blank, S E; Gallucci, R M; Pfister, L J

1993-03-01

Female C57BL/6 mice were fed a defined, pelleted diet and given 10% w/v or 20% w/v ethanol in their drinking water. Natural killer (NK) cell cytolytic activity was compared between water-drinking and ethanol-consuming mice and in mice that were also treated with polyinosinic-polycytidylic acid (poly I:C) to augment NK cell activity or with anti-NK1.1 antibody to decrease activity. NK cell cytolytic activity was not altered in mice given 10% ethanol, but was decreased in mice given 20% ethanol compared to water-drinking mice. Poly I:C treatment increased and anti-NK1.1 antibody treatment decreased NK cell activity in both water-drinking and 20% ethanol-consuming mice. Experimental and spontaneous metastases of B16-BL6 melanoma were evaluated as a function of the duration of ethanol consumption before tumor inoculation and as a function of altered NK cell activity. Experimental metastasis was inhibited after 4 and also after 6.5 weeks of ethanol exposure. Poly I:C treatment inhibited tumor lung colonization irrespective of ethanol consumption. Anti-NK1.1 antibody treatment increased metastasis, although to a lesser degree in mice consuming 10% ethanol. Spontaneous metastasis was inhibited in mice consuming 10% ethanol for 4 weeks, and in mice consuming 20% ethanol for 1 and 4 weeks before melanoma inoculation.

F1 hybrids of BALB/c and C57BL/6 mouse strains respond differently ...

Indian Academy of Sciences (India)

cross was decided between C57BL/6 female and BALB/c ... on the mouse 7.4k cDNA microarray slide (University Health ... The ratio of two-fold increase (2.0) or decrease (−2.0) in ... were carried out to validate data from the cDNA micror- ray.

Malle Talveti huvitavad naised / Kärt Hellerma

Index Scriptorium Estoniae

Hellerma, Kärt, 1956-

2006-01-01

Arvustus: McCullers, Carson. Laulatuse lummas / tõlk. Malle Talvet. Tallinn : Perioodika, 1988. (Loomingu Raamatukogu ; 1988, 3-5) ; Duras, Marguerite. Armuke / tõlk. Malle Talvet. Tallinn : Perioodika, 1988. (Loomingu Raamatukogu ; 1988, 11-12) ; Brookner, Anita. Hotel du Lac / tõlk. Malle Talvet. Tallinn : Perioodika, 1990. (Loomingu Raamatukogu ; 1990, 45-46). Varem ilmunud: Eesti Elu nr. 1 (13), 1. veebruar 1991

Kirjanik soovitab / Heiki Vilep

Index Scriptorium Estoniae

Vilep, Heiki, 1960-

2009-01-01

Tutvustus: Pratt, David. Võimatu nõuab rohkem aega : 1000 tarkusetera Nobeli preemia laureaadilt / inglise keelest tõlkinud Marge Paal. [Tallinn] : Ersen, 2009 ; Varblane, Hannes. Taarnateel : katsetusi 1967–1970 : [luuletused]. Tartu : Ilmamaa, 2009 ; Eesti muinasjuttude kuldraamat / koostanud Reet Krusten. Tallinn : TEA Kirjastus, 2009 ; Eco, Umberto. Kuus jalutuskäiku kirjandusmetsades / inglise keelest tõlkinud Ene-Reet Soovik. Tallinn : Varrak, 2009

[Raamatute tutvustus] / Tiit Pruuli

Index Scriptorium Estoniae

Pruuli, Tiit, 1965-

2010-01-01

Tutvustus: Asmus, Ronald D. Väike sõda, mis raputas maailma. Gruusia, Venemaa ja Lääne tulevik. Tallinn : Eesti Ajalehed, 2010 ; Ševardnadze, Eduard. Kui raudne eesriie rebenes. Tallinn : Olion, 2009 ; Vene-Gruusia sõda 08.08.2008. Kuidas see tegelikkuses oli. Tallinn : Kniga.ee, 2010 ; Raudam, Dagmar. Minu Gruusia. Elu nagu mägitee. Tartu : Petrone Print, 2010

Väike luulekaleidoskoop. III / Jürgen Rooste

Index Scriptorium Estoniae

Rooste, Jürgen, 1979-

2009-01-01

Ülevaade järgmistest luuleraamatutest: Anmann, Aarne. Südametunnistuse mälestuseks. Tartu : A. Anmann, 2009 ; Ilmet, Peep. Meilmail. Tallinn : Varrak, 2009 ; Kasemaa, Andrus. Lagunemine. Tallinn : Eesti Keele Sihtasutus, 2009 ; Kuus, Anti ; Oll, Sulev. Öö mõte on kuus. Tallinn : Akta A. K., 2008 ; Meres, Triinu. Lagunemine. Tartu : Hermes, 2009 ; Tasuja, Triin. Provintsiluule. Tartu : Värske Rõhk, 2009

EPSP of L. casei BL23 Protected against the Infection Caused by Aeromonas veronii via Enhancement of Immune Response in Zebrafish.

Science.gov (United States)

Qin, Chubin; Zhang, Zhen; Wang, Yibing; Li, Shuning; Ran, Chao; Hu, Jun; Xie, Yadong; Li, Weifen; Zhou, Zhigang

2017-01-01

Aquaculture is the fastest-growing food production sector in the world, and it supplies nearly 50% of the global food fish supply. However, disease outbreaks have become a major problem in the fish farming industry. The beneficial contribution of probiotic bacteria to aquatic animals' health has been widely described, and they have been widely used in aquaculture for disease control and growth promotion. However, the action of probiotic bacterial components and mechanisms underlying protection against pathogens afforded by probiotic bacteria remain poorly understood. In the present study, we pre-colonized zebrafish larvae (before hatching) with 17 potential probiotic bacterial strains and screened for those possessing anti-infective effects against Aeromonas veronii . We found that Lactobacillus casei BL23 significantly increased the survival of zebrafish larvae upon A. veronii infection. Using a germ-free (GF) zebrafish model and gut microbiota transplant experiment, we showed that L. casei BL23 per se has anti-infective effects in zebrafish larvae, which does not involve microbiota. Furthermore, we identified an exopolysaccharide-protein complex (EPSP) extracted from L. casei BL23 cells, which consisted of a 40-45 KD size protein and an exopolysaccharide composed of α-Rha, α-Glc, β-GlcNAc, and β-GalNAc. EPSP significantly increased the survival rate of GF zebrafish at a dose of 10-20 μg/ml after A. veronii infection ( P casei BL23 was mediated by enhancement of immune responses in zebrafish, which might involve the TLR1/TLR2 signal pathway.

Correlated radio and optical variability in the BL Lacertae object 0716 + 714

International Nuclear Information System (INIS)

Quirrenbach, A.; Witzel, A.; Krichbaum, T.P.; Wagner, S.; Sanchez-pons, F.

1991-01-01

Results are presented from simultaneous optical and radio observations of the BL Lacertae object 0716 + 714. During a 4-week period of continuous monitoring the source displayed in both wavelength regimes a transition between states of fast and slow variability with a change of the typical variability time scale from about 1 day to about 7 days. The simultaneous transition is interpreted as evidence for intrinsic source variability, and some consequences for the optical and radio emission regions are discussed. 19 refs

Systematic comparison of co-expression of multiple recombinant thermophilic enzymes in Escherichia coli BL21(DE3).

Science.gov (United States)

Chen, Hui; Huang, Rui; Zhang, Y-H Percival

2017-06-01

The precise control of multiple heterologous enzyme expression levels in one Escherichia coli strain is important for cascade biocatalysis, metabolic engineering, synthetic biology, natural product synthesis, and studies of complexed proteins. We systematically investigated the co-expression of up to four thermophilic enzymes (i.e., α-glucan phosphorylase (αGP), phosphoglucomutase (PGM), glucose 6-phosphate dehydrogenase (G6PDH), and 6-phosphogluconate dehydrogenase (6PGDH)) in E. coli BL21(DE3) by adding T7 promoter or T7 terminator of each gene for multiple genes in tandem, changing gene alignment, and comparing one or two plasmid systems. It was found that the addition of T7 terminator after each gene was useful to decrease the influence of the upstream gene. The co-expression of the four enzymes in E. coli BL21(DE3) was demonstrated to generate two NADPH molecules from one glucose unit of maltodextrin, where NADPH was oxidized to convert xylose to xylitol. The best four-gene co-expression system was based on two plasmids (pET and pACYC) which harbored two genes. As a result, apparent enzymatic activities of the four enzymes were regulated to be at similar levels and the overall four-enzyme activity was the highest based on the formation of xylitol. This study provides useful information for the precise control of multi-enzyme-coordinated expression in E. coli BL21(DE3).

Relations between open-field, elevated plus-maze, and emergence tests as displayed by C57/BL6J and BALB/c mice.

Science.gov (United States)

Lalonde, R; Strazielle, C

2008-06-15

The relations between open-field, elevated plus-maze, and emergence tests were examined in two strains of mice. In the open-field, C57BL/6J mice had more ambulatory movements and rears but not stereotyped movements relative to BALB/c. In addition, C57BL/6J mice entered more often than BALB/c into enclosed and open arms of the elevated plus-maze. When placed inside a large enclosure, C57BL/6J mice emerged more quickly than BALB/c from a small toy object. In the entire series of mice, ambulation and rears in the open-field were linearly correlated with open and enclosed arm visits in the elevated plus-maze. Ambulatory movements and rears were also correlated with emergence latencies. In contrast, stereotyped movements were correlated with emergence latencies, but not with any elevated plus-maze value. These results specify the extent and limits of association between the three tests.

Muulane või surmasõlm / Vaapo Vaher

Index Scriptorium Estoniae

Vaher, Vaapo, 1945-

2007-01-01

Tutvustus: Ivinskaja, Olga. Aastad Boriss Pasternakiga, ehk, Aja vangis / tlk. Vilma Matsov. Tallinn : Varrak, 2006 ; Baranov, Vadim. Maksim Gorki. Elu ja surma saladus / tlk. Jüri Pärni. Tallinn : Kunst, 2006 ; Troyat, Henri. Aleksander III : lumetsaar / tlk. Jana Porila. Tallinn : Eesti Raamat, 2006 ; Runnel, Hando. Viru veri ei värise. [Tartu] : Ilmamaa, 2006 ; Pärnik, Ylo M. Dr. Julius von Scultz-Bertram. Tartu : Ilmamaa, 2006

Quasi-simultaneous observations of BL Lac object Mrk 501 in X-ray, UV, visible, IR, and radio frequencies

International Nuclear Information System (INIS)

Kondo, Y.; Worrall, D.M.; Mushotzky, R.F.; Hackney, R.L.; Hackney, K.R.H.; Oke, J.B.; Yee, H.K.C.; Neugebauer, G.; Matthews, K.; Feldman, P.A.; Brown, R.L.

1981-01-01

Quasi-simultaneous observations of the BL Lac object Mrk 501 were performed for the first time at X-ray, ultraviolet, visible infrared, and radio frequencies. As the BL Lac objects are known to vary in their flux, such a ''quasi-instantaneous'' spectral energy profile is necessary in order to describe properly the energy generation mechanism. The observed spectral slope from the X-ray to UV regions is positive and continuous, but that from the mid-UV to visible light region becomes gradually flat and possibly turns down toward lower frequencies; the optical-radio emission cannot be accounted for by a single power law. Several theoretical models have been considered for the emission mechanism. In some cases quantitative comparison with the data is not practical. However, most of the models are, at least, not inconsistent with the observations. A quantitative comparison has been peformed with the synchroton self-Compton model; the total spectrum is found consistent with this model. The spectrum from visible light to X-ray is consistent with synchrotron radiation or with inverse-Compton scattering by a hot thermal cloud of electrons. The continuity of the spectral slope from X-ray to UV implied by the current data suggests that the previous estimates of the total luminosity of this BL Lac object has been underestimated by a factor of about 3 or 4

Gaining trust in emerging markets. Principles of FiBL projects and its cooperation in South East Europe

OpenAIRE

Schneider, Monika

2006-01-01

FiBL principles, working approach - Respond to local partners requests - Market oriented approach - Promote sustainability of local partners, set up of institutional framework for organic sector development, to develop service provider - Knowledge transfer to local institutions - Long term cooperation

Ultrasonic assisted dyeing: dyeing of acrylic fabrics C.I. Astrazon Basic Red 5BL 200%.

Science.gov (United States)

Kamel, M M; Helmy, H M; Mashaly, H M; Kafafy, H H

2010-01-01

The dyeing of acrylic fabrics using C.I. Astrazon Basic Red 5BL 200% has been studied with both conventional and ultrasonic techniques. The effect of dye concentration, dye bath pH, ultrasonic power, dyeing time and temperature were studied and the resulting shades obtained by dyeing with both techniques were compared. Colour strength values obtained were found to be higher with ultrasonic than with conventional heating. The results of fastness properties of the dyed fabrics were studied. X-ray and Scanning Electron Microscope SEM were carried out on dyed samples using both methods of dyeing to find out an explanation for the better dyeability of acrylic fabrics with (US) method. Dyeing kinetics of acrylic fabrics using C.I. Astrazon Basic Red 5BL 200% using conventional and ultrasonic conditions were compared. The time/dye-uptake isotherms are revealing the enhanced dye-uptake in the second phase of dyeing. The values of dyeing rate constant, half-time of dyeing and standard affinity and ultrasonic efficiency have been calculated and discussed.

UV spectrum of the BL Lac object PKS 0521-36

Energy Technology Data Exchange (ETDEWEB)

Danziger, I.J. (European Southern Observatory, Garching (Germany, F.R.)); Bergeron, J. (Centre National de la Recherche Scientifique, 75 - Paris (France). Inst. d' Astrophysique); Fosbury, R.A.E. (Royal Greenwich Observatory, Hailsham (UK)); Maraschi, L.; Treves, A. (Consiglio Nazionale delle Ricerche, Milan (Italy). Lab. di Fisica Cosmica; Milan Univ. (Italy). Ist. di Fisica); Tanzi, E.G. (Consiglio Nazionale delle Ricerche, Milan (Italy). Lab. di Fisica Cosmica)

1983-05-01

Ultraviolet observations (1200 to 3000 A) with the IUE satellite of the BL Lac object PKS 0521-36 are presented. The only emission line which appears clearly in the spectrum is Ly..cap alpha.., which is asymmetric with a component displaced approx. 3000 km s/sup -1/ to the red. The intensity of the line and the upper limits on other lines are compared with the model calculations on QSOs and Seyfert nuclei by Kwan and Krolik. The continuous energy distribution is discussed, combining non-simultaneous observations from the ultraviolet to the infrared. The spectral range of the non-thermal source from far IR to far UV can be described by a single power law of index -1.5.

Efficacy of in vitro sensitized cells generated by in vivo priming with OK-432 for adoptive immunotherapy of the poorly immunogenic B16-Bl6 melanoma.

Science.gov (United States)

Mukai, S; Kato, H; Kimura, S; Asai, K; Kawahito, Y; Inoue, M; Yamamura, Y; Sano, H; Sugino, S; Shu, S; Kondo, M

1996-02-01

We investigated the efficacy of the streptococcal preparation OK-432 as an adjuvant for in vivo priming in induction of sensitized cells for adoptive immunotherapy of the poorly immunogenic B16-BL6 (BL6) melanoma. C57BL/6 (B6) mice were immunized subcutaneously (s.c.) with 3 x 10(6) viable BL6 tumor cells admixed with various doses of OK-432 ranging from 1 to 100 micrograms in the foot-pad. Draining popliteal lymph nodes (LNs) were harvested 7 days after immunization and LN cells were further sensitized with irradiated tumor cells in the presence of 60-300 IU/ml of IL-2 for 11 days. These in vitro sensitized (IVS) cells (2 x 10(6)) were transferred intravenously (i.v.) to B6 mice bearing 4-day pulmonary metastases established by i.v. injection of 2-4 x 10(5) viable BL6 cells. The mice were also received intraperitoneally (i.p.) 4 x 10(4) IU/day of IL-2 for 4 days after adoptive transfer. Transfer of IVS cells from mice immunized by s.c. injection of tumor cells admixed with 10 micrograms of OK-432 significantly reduced the numbers of BL6 pulmonary metastases compared with that of control IVS' cells without the administration of OK-432 (P = 0.003). These effective IVS cells also significantly prolonged the survival of treated animals (P = 0.003). Functional IVS cells required in vitro stimulation with tumor cells. However, addition of OK-432 in the vaccine resulted in no enhancement of in vitro cytotoxicity and no characteristic change of phenotype of IVS cells. These results suggest that in vivo priming of OK-432 facilitates the sensitization of tumor-reactive T-cells. The procedure of in vivo priming with OK-432 may be beneficial in the adoptive immunotherapy of melanoma.

[Establishment of Social Stress Induced Depression-like Animal Model in Mice of C57BL/6 Strain and Behavioral Assessments].

Science.gov (United States)

Li, Mi-hui; Wu, Xiao; Wei Ying; Dong, Jing-cheng

2016-02-01

To establish social stress induced depression-like model in mice of C57BL/6 strain, and to assess its reliability using differenf behavioral methods. Totally 20 male mice of C57BL/6 strain were divided into the normal group and the stress model group by random digit table,10 in each group. Another 10 CD1 mice were subjected to social stress. Mice in the normal control group received no stress, while those in the model group received social stress for 10 successive days. Behavioral assessment was performed using social interaction test (SIT), the elevated plus-maze (EPM) test, tail suspension test (TST), respectively. Serum cortisol level was detected by ELISA to assess the reliability of the model. In the social interaction test when the social target (CDI mice) was inexistent, mice in the normal control group spent longer time in the social interaction zone and less time in the corner zone (P stress induced depression-like animal model in mice of C57BL/6 straineasquite reliable and possibly suitable to be used in integrative medicine research of combination of disease and syndrome model.

Exacerbation of substrate toxicity by IPTG in Escherichia coli BL21(DE3) carrying a synthetic metabolic pathway.

Science.gov (United States)

Dvorak, Pavel; Chrast, Lukas; Nikel, Pablo I; Fedr, Radek; Soucek, Karel; Sedlackova, Miroslava; Chaloupkova, Radka; de Lorenzo, Víctor; Prokop, Zbynek; Damborsky, Jiri

2015-12-21

Heterologous expression systems based on promoters inducible with isopropyl-β-D-1-thiogalactopyranoside (IPTG), e.g., Escherichia coli BL21(DE3) and cognate LacI(Q)/P(lacUV5)-T7 vectors, are commonly used for production of recombinant proteins and metabolic pathways. The applicability of such cell factories is limited by the complex physiological burden imposed by overexpression of the exogenous genes during a bioprocess. This burden originates from a combination of stresses that may include competition for the expression machinery, side-reactions due to the activity of the recombinant proteins, or the toxicity of their substrates, products and intermediates. However, the physiological impact of IPTG-induced conditional expression on the recombinant host under such harsh conditions is often overlooked. The physiological responses to IPTG of the E. coli BL21(DE3) strain and three different recombinants carrying a synthetic metabolic pathway for biodegradation of the toxic anthropogenic pollutant 1,2,3-trichloropropane (TCP) were investigated using plating, flow cytometry, and electron microscopy. Collected data revealed unexpected negative synergistic effect of inducer of the expression system and toxic substrate resulting in pronounced physiological stress. Replacing IPTG with the natural sugar effector lactose greatly reduced such stress, demonstrating that the effect was due to the original inducer's chemical properties. IPTG is not an innocuous inducer; instead, it exacerbates the toxicity of haloalkane substrate and causes appreciable damage to the E. coli BL21(DE3) host, which is already bearing a metabolic burden due to its content of plasmids carrying the genes of the synthetic metabolic pathway. The concentration of IPTG can be effectively tuned to mitigate this negative effect. Importantly, we show that induction with lactose, the natural inducer of P lac , dramatically lightens the burden without reducing the efficiency of the synthetic TCP degradation

BLENDED LEARNING (BL AS PEDAGOGICAL ALTERNATIVE TO TEACH BUSINESS COMMUNICATION COURSE: Case Study of UUM Executive Diploma Program

Directory of Open Access Journals (Sweden)

Hisham DZAKIRIA

2012-07-01

Full Text Available Globally, blended learning (BL technologies have been increasingly applied in a variety of fields, both public and private sectors. In recent years, universities, public and private businesses and organizations are among those employing blended learning methods and technologies in training and re-training of professionals in the workforce. In Malaysia, the increasing use of blended learning to enhance learning and enriching of soft skills among professionals and individuals in the work place is evident. The advancement of technology is an onset to many new avenues and tool for learning and teaching, and it is the coalescing of these various technologies with particular pedagogy or andragogy has helped to popularize BL. However, when an institution makes the critical choice of delivery methods, it is pertinent that the university needs to consider various success factors. One in particular is student-centered approach that entails the need to understand the students as the beneficiary of learning, and the support system they need to help them learn. This qualitative study reports in detail the experience of a small group of students undertaking Executive Diplomas at Executive Development Centre (EDC, Universiti Utara Malaysia as they progress through their Executive program. This paper looks at learning experiences as described by the learners- it is their story, their experience, and their perspective. This study suggests that BL offered a comfortable middle ground, and has lots of potential in higher education in Malaysia. It is a pedagogical alternative that could play a significant role not only for teaching Business Communication, but has the potential to promote lifelong learning initiatives in Malaysia in a much meaningful and inviting way. Although this study shows that BL contributed a significant and meaningful learning particularly for adult learners, it needs more definitive studies. Such information can be used to guide policy makers

Inhibition of B16-BL6 melanoma lung colonies by semisynthetic sulfaminoheparosan sulfates from E. coli K5 polysaccharide.

Science.gov (United States)

Poggi, Andreina; Rossi, Cosmo; Casella, Nicola; Bruno, Cristiana; Sturiale, Luisella; Dossi, Carla; Naggi, Annamaria

2002-08-01

Heparin (H), heparan sulfate (HS), and related glycosaminoglycans can inhibit cancer cell invasion, possibly due to their ability to interact with vascular growth factors, adhesion molecules, endoglycosidases, and signaling proteins, in addition to the well-known effects on the clotting system. We evaluated the antitumor activity of a series of semisynthetic sulfaminoheparosan sulfates (SAHSs) with different degree and distribution of sulfates, obtained by chemical modifications of the E. coli K5 polysaccharide, namely type A, B, and C compounds. B16-BL6 melanoma cells (10 5 cells/mouse) were injected intravenously (i.v.) in a lateral tail vein of C57BL6 mice at a dose of 0.5 mg/ mouse together with test compounds. Tumor lung nodules were significantly reduced as compared with controls only by H (95.5 +/- 1.0% inhibition), SAHS-2 (84.2 +/- 5.0% inhibition), and SAHS-4 (91.1 +/- 4.2% inhibition), among compounds tested. SAHS-2 and SAHS-4 are type B compounds, with a sulfate/carboxylate ratio similar to that of H. A typical mammalian HS showed only 54.8% inhibition. Supersulfated low-molecular-weight heparin and heparan sulfate (ssLMWH and ssLMWHS) showed an activity similar to that of unfractionated compounds. H and SAHS-4 inhibited dose dependently B16-BL6 lung colonies, with IC-50 values of 0.05 and 0.1 mg/mouse, respectively. The relationship with ex vivo anticoagulant potency was evaluated by activated partial thromboplastin time (aPTT) on mouse plasma at different time intervals after i.v. injection (0.1 to 0.5 mg/mouse) of the compound. H showed a dose-dependent anticoagulant activity lasting up to 2 hours, whereas SAHS-4 showed a potent anticoagulant effect only at a dose of 0.5 mg/mouse. Accordingly, H but not SAHS-4 consistently inhibited B16-BL6 lung colonies when given 1 hour before tumor cells. SAHS-4 derivatives, with different size and/or affinity depleted of AT binding sites, showed an inhibitory effect on B16-BL6 melanoma similar to that of SAHS-4

Postnatal hematopoiesis and gut microbiota in NOD mice deviate from C57BL/6 mice

DEFF Research Database (Denmark)

Damlund, Dina Silke Malling; Metzdorff, Stine Broeng; Hasselby, Jane Preuss

2016-01-01

, a distinct splenic cell profile high in a granulocytic phenotype was evident in the neonatal NOD mice whereas neonatal C57BL/6 mice showed a profile rich in monocytes. Neonatal expression of Reg3g and Muc2 in the gut was deviating in NOD mice and coincided with fewer bacteria attaching to the Mucosal surface...

Twin City - past 1823-2013 : EHTE ja Haaga-Helia ühisprojekt / Tiit Kask, Ain Hinsberg

Index Scriptorium Estoniae

Kask, Tiit

2012-01-01

Turismikoolide ühisprojektist "Twin City - Empowering & Designing Twin-Capital Destination - Past, Present and Future of Tourism in Greater-Helsinki and Greater-Tallinn Area", mille eesmärgiks on Tallinna ja Helsingi kui ühtse turismisihtkoha käsitluse loomine ja 26. aprillil Tallinnas toimunud seminarist "TwinCity Helsinki-Tallinn / Tallinn & Estonian tourism 1813-2013", mis kutsus üles tähistama Tallinna (Kadrioru) merekuurordi ja "Eesti Turismimajandus 200" juubelit 2013. aastal

Kolakowski : kaks vaatepunkti, kaks dialektikat / Andre Trinity

Index Scriptorium Estoniae

Trinity, André, pseud., 1974-

2004-01-01

Rets. rmt.: Kolakowski, Leszek. Horror metaphysicus. Tallinn, 2000 ; Kolakowski, Leszek. Religioon : Kui Jumalat ei ole olemas...Jumalast, kuradist, patust ja nn religioonifilosoofia teistest muredest. Tallinn, 2004

Raamatupärlid / Mihkel Mutt

Index Scriptorium Estoniae

Mutt, Mihkel, 1953-

2007-01-01

Tutvustus: Traat, Mats. Naised ja pojad ajakirjas Looming, nr. 2-5 ; Applebaum, Anne. Gulag. Tallinn : Varrak, 2005 ; Yourcenar, Marguerite. Silmapaistmatu inimene. Ilus hommik. Tallinn : Kultuurileht, 2006

THE VOLATILE COMPOSITION OF COMET C/2003 K4 (LINEAR) AT NEAR-IR WAVELENGTHS—COMPARISONS WITH RESULTS FROM THE NANÇAY RADIO TELESCOPE AND FROM THE ODIN, SPITZER, AND SOHO SPACE OBSERVATORIES

Energy Technology Data Exchange (ETDEWEB)

Paganini, L.; Mumma, M. J.; Villanueva, G. L.; DiSanti, M. A.; Bonev, B. P., E-mail: lucas.paganini@nasa.gov [Goddard Center for Astrobiology, NASA GSFC, MS 690, Greenbelt, MD 20771 (United States)

2015-07-20

We observed comet C/2003 K4 (LINEAR) using NIRSPEC at the Keck Observatory on UT 2004 November 28, when the comet was at 1.28 AU from the Sun (post-perihelion) and 1.38 AU from Earth. We detected six gaseous species (H{sub 2}O, OH*, C{sub 2}H{sub 6}, CH{sub 3}OH, CH{sub 4}, and HCN) and obtained upper limits for three others (H{sub 2}CO, C{sub 2}H{sub 2}, and NH{sub 3}). Our results indicate a water production rate of (1.72 ± 0.18) × 10{sup 29} molecules s{sup −1}, in reasonable agreement with production rates from SOHO (on the same day), Odin (one day earlier), and Nançay (about two weeks earlier). We also report abundances (relative to water) for seven trace species: CH{sub 3}OH (∼1.8%), CH{sub 4} (∼0.9%), and C{sub 2}H{sub 6} (∼0.4%) that were consistent with mean values among Oort cloud (OC) comets, while NH{sub 3} (<0.55%), HCN (∼0.07%), H{sub 2}CO (<0.07%), and C{sub 2}H{sub 2} (<0.04%) were “lower” than the mean values in other OC comets. We extracted inner-coma rotational temperatures for four species (H{sub 2}O, C{sub 2}H{sub 6}, CH{sub 3}OH, and CH{sub 4}), all of which are consistent with 70 K (within 1σ). The extracted ortho-para ratio for water was 3.0 ± 0.15, corresponding to spin temperatures larger than 39 K (at the 1σ level) and agreeing with those obtained with the Spitzer Space Telescope at the 2σ level.

Radix Stellariae extract prevents high-fat-diet-induced obesity in C57BL/6 mice by accelerating energy metabolism

Directory of Open Access Journals (Sweden)

Yin Li

2017-05-01

Full Text Available Stellaria dichotoma L. is widely distributed in Ningxia and surrounding areas in northwestern China. Its root, Radix Stellariae (RS, has been used in herbal formulae for treating asthenic-fever, infection, malaria, dyspepsia in children and several other symptoms. This study investigated whether the RS extract (RSE alleviates metabolic disorders. The results indicated that RSE significantly inhibited body weight gain in high-fat (HF-diet-fed C57BL/6 mice, reduced fasting glucose levels, and improved insulin tolerance. Moreover, RSE increased the body temperature of the mice and the expression of uncoupling proteins and peroxisome proliferator-activated receptors in the white adipose tissue. Thus, RSE alleviated metabolic disorders in HF-diet-fed C57BL/6 mice by potentially activating UCP and PPAR signaling.

Marguerite Duras ja tema võimukolmnurgad / Kärt Hellerma

Index Scriptorium Estoniae

Hellerma, Kärt, 1956-

2007-01-01

Arvustus: Duras, Marguerite. Armuke / tlk. Malle Talvet. Tallinn : Perioodika, 1989. (Loomingu Raamatukogu ; 1989, 11-12) ; Duras, Marguerite. Tamm Vaikse ookeani vastu / tlk. Triinu Tamm. Tallinn : Varrak, 2006

Forgotten Sunrise "Forgotten Sunrise. Behind The Abysmal Sky / Forever Sleeping Greystones". "The Moments When God Was Wrong" / Siim Nestor

Index Scriptorium Estoniae

Nestor, Siim, 1974-

2009-01-01

Arvustus: Forgotten Sunrise. Behind The Abysmal Sky / Forever Sleeping Greystones. [Tallinn] : Nailboard, 2009. Forgotten Sunrise. The Moments When God Was Wrong. [Tallinn] : Forgotten Sunrise, 2009. Uutest heliplaatidest

Uue oskuse võlu / Helen Talalaev

Index Scriptorium Estoniae

Talalaev, Helen

2009-01-01

Tutvustatakse kirjastuse TEA väljaantud õppekomplekte: Tomalin, Barry. Westminster English. Tallinn : TEA Kirjastus, 2009 ; Mangus, Inga. Vene keele õpik : algajale ja taasalustajale. Tallinn : TEA Kirjastus, 2008

Kolm debüüti / Jaak Urmet

Index Scriptorium Estoniae

Urmet, Jaak, 1979-

2001-01-01

Arvustus: Afanasjev, Vahur. Kandiline maailm. Tartu : Irboska Teataja Kirjastus, 2000 ; Ehin, Kristiina. Kevad Astrahanis : luuletusi 1992-1999. Tallinn : Huma, 2000 ; Kaldmaa, Jüri. Passioon. Tallinn : Huma, 2000

Kunst ja selle tegijad kuulugu rahvale / Stella Sägi

Index Scriptorium Estoniae

Sägi, Stella

2004-01-01

Kruus, Oskar. Kakskümmend üks pulma ja üksteist surma : kirjanduslooliste vestete kogumik. Tallinn : Faatum, 2003 ; Kruus, Oskar. Parunessi pihtimus : [biograafiline romaan]. Tallinn : Faatum, 2004

"Oh, homme on jälle kunst! Mida ma küll tunnis teen?" / Edna Vahter

Index Scriptorium Estoniae

Vahter, Edna

2002-01-01

Kunstiõpetusest alushariduses. Rmt. : Vahter, Edna. Kinnipüütud lehesadu : [kunstiõpetuse vihik]. - [Tallinn] : Avita, 2001; Vahter, Edna. Lumisem lumeaeg : [kunstiõpetuse vihik]. - [Tallinn] : Avita, 2001

The experimental apparatus for synchrotron radiation Moessbauer spectroscopy of BL11 in SPring-8

International Nuclear Information System (INIS)

Mitsui, T.; Kitao, S.; Zhang, X.W.; Marushita, M.; Seto, M.

2001-01-01

Synchrotron radiation Moessbauer spectroscopy (time spectrum of nuclear forward scattering and nuclear resonant inelastic scattering) enables us to study both the electronic state and lattice dynamics of a target material. Furthermore, the excellent properties of synchrotron radiation (polarization, pulse, small beam size) promise us the unique studies for material science. In order to progress in these studies, some experimental apparatuses were installed in BL11XU of SPring-8

Hingekeeled ajaloo kuumas tolmus / Jan Kaus

Index Scriptorium Estoniae

Kaus, Jan, 1971-

2011-01-01

Arvustus: Hargla, Indrek. Apteeker Melchior ja timuka tütar : kriminaalromaan vanast Tallinnast. Tallinn : Varrak, 2011 ja Aleksejev, Tiit. Kindel linn : lugu Esimesest ristisõjast. Tallinn : Varrak, 2011

Ilmusid Ollinovski ja Pessoa kogud

Index Scriptorium Estoniae

2009-01-01

Ollinovski, Jim. Aeroplaan esimesest pilgust. Tallinn : Pilgrim, 2009 ; Pessoa, Fernando. Tubakapood : ́Alvaro de Campose viimased luuletused. Tallinn : Pilgrim Group, 2009. Esitlus 2. dets. Tallinnas Von Krahli teatris

Kodakondsus - kas integratsiooni eeldus või tulemus? / Klara Hallik

Index Scriptorium Estoniae

Hallik, Klara

2000-01-01

Eestlaste ja mitteeestlaste ootused kodakondsuspoliitika suhtes on jätkuvalt vastandlikud. Ilm. ka: Integration of Estonian Society : monitoring 2000.- Tallinn, 2000 ; Integratsija Estonskogo obshtshestva : monitoring 2000.- Tallinn, 2000

[Musikwissenschaftliche Literatur] / Kristel Pappel

Index Scriptorium Estoniae

Pappel, Kristel, 1961-

1999-01-01

Tutvustus: Urve Lippus (toim.). Music history writing and national culture. Proceedings of a seminar : Tallinn, Detsember 1-3, 1995. Eesti muusikaloo toimetised 1. Tallinn : Eesti Keele Instituut, 1995

Tekst ja subjekt. Tartu koolkonna teine põlvkond / Marek Tamm

Index Scriptorium Estoniae

Tamm, Marek, 1973-

1997-01-01

Arvustus: Lotman, Mihhail. Mandelshtam i Pasternak : popõtka kontrastivnoi poetiki. Tallinn : Aleksandra, 1996. (Biblioteka zhurnala Tallinn); Torop, Peeter. Dostojevski : istorija i ideologija. Tartu : Tartu Ülikooli Kirjastus, 1997

Vaike Kiik-Salupere doktoritööst "Esinemiseks valmistumine ja esinemisärevusega toimetulek klassikaliste lauljate vokaalpedagoogikas" / Allan Vurma

Index Scriptorium Estoniae

Vurma, Allan, 1955-

2014-01-01

Arvustus: Kiik-Salupere, Vaike. Performance preparation and coping with performance anxiety in the vocal pedagogy of classical singers. Tallinn : Tallinn University, 2013. (Tallinna Ülikooli sotsiaalteaduste dissertatsioonid ; 64)

Study feature of variability extragalactic radio sources 3C 446 and BL Lac in the centimeter wavelength range

International Nuclear Information System (INIS)

Sukharev, A.L.

2015-01-01

This work presents the results of the analysis of long-term monitoring (over 40 years) changes in radio fluxes of the two extragalactic sources - 3C 446, and BL Lac. Observations at frequencies of 14.5, 8, 4.8 GHz were obtained in the Michigan Radio Astronomy Observatory (UMRAO). With using Fourier filtering were selected 0- C (short-period), and the trend component of flux variations that were analyzed separately with using the wavelet-analysis method. Each of these components is associated with certain physical processes in the 'core-accretion disk-jet' system. Were constructed time-frequency wavelet-spectra showing the changes of the frequency composition of the investigated data over time. For the trend component values of the main periods of -4-9 years (3C 446) and -8 years (BL Lac), for 0- C component -0.8-3 years (3C 446) and -0.6-4 years (BL Lac) and they appear in the temporal and structural changes of the jet. On the basis of calculating the global wavelet-spectra in the frequency range identified main phases activity of radio sources. Obtained comparison between the dynamics of jets (Mojave VLBI images), and change the frequency spectral structure of the studied data. With bandpass wavelet filtering, flux components corresponding to the main periods in the spectra, were identified and also found the delay between the observation frequencies in spectral bands of these periods

Methamphetamine protects against MPTP neurotoxicity in C57BL mice.

Science.gov (United States)

Sziráki, I; Kardos, V; Patthy, M; Pátfalusi, M; Budai, G

1994-01-14

Methamphetamine (5 mg/kg) administered 30 min prior to each injection with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (3 x 30 mg/kg, at 24 h intervals) prevents the reduction of striatal levels of dopamine and its metabolites in C57BL mice. Methamphetamine and amphetamine inhibit the uptake of 1-methyl-4-phenylpyridinium (MPP+) by striatal synaptosomes of rats. A 30-min post-treatment with methamphetamine or amphetamine also prevents the MPTP-induced dopamine depletion, suggesting that their protective effect is related to the blockade of MPP+ uptake into dopaminergic neurons. Since amphetamine and methamphetamine are themselves neurotoxins at higher doses, this work demonstrated the protection against the actions of one neurotoxin by the administration of another.

Kes on tõusmas relvile? / Jürgen Rooste

Index Scriptorium Estoniae

Rooste, Jürgen, 1979-

2004-01-01

Arvustus: Oja, Martin., keelatud raamat : tekste 1996-2000. Tallinn : 9 Koma, 2003 ; Klaus, Eduard. Pommikutsikas. Tartu : Ilmamaa, 2003 ; Mölter, Artur. Leitud hing... ja purunenud süda. Põltsamaa : A. Mölter, 2003 ; Kera, Mihkel. Tähelepanekuid noorusaastatest. I. k. : Kirja Kerrallaan, 2003 ; Valme, Villem. Artur Tõhu unenägu. Tallinn : Paala Järv, 2003 ; Valdmann, Astrid, Kagovere, Ott. Haiged lapsed. Sutlema (Raplamaa) : A. Valdmann, 2004 ; Olematu, Olev. Ederlezi. [Tallinn] : Huma, 2003

Raamatuid / Juhan Habicht

Index Scriptorium Estoniae

Habicht, Juhan, 1954-

1992-01-01

Raamatud: Kareva, Doris. Kuuhobune. [Tallinn] : Katherine, [1992]. Imelik, Olaf. Tõde - kõige kaunim oled sa alasti. Tallinn : Mats, [1992]. Murutar, Kati. Naisena sündinud. [Pärnu] : Perona, 1992

B. B. ja järelpõlved / Ave Mattheus

Index Scriptorium Estoniae

Mattheus, Ave

2007-01-01

Arvustus: Enzensberger, Hans Magnus. Tõmba sobimatu maha / saksa keelest tlk. Maarja Kangro. Tallinn : Kultuurileht, 2006 (Loomingu Raamatukogu ; 33) ; Brecht, Bertolt. Luulet / koost. Märt Väljataga. Tallinn : Vagabund, 2007

Sündinud kunstnikuks - kahe Eestis kasvanud juudi lugu / Rein Veidemann

Index Scriptorium Estoniae

Veidemann, Rein, 1946-

2009-01-01

Arvustus: Tali, Piret. Eino Baskin. Naer läbi pisarate / kirja pannud Piret Tali. [Tallinn] : Fookus Meedia, [2009] ; Tammer, Enno. Simon Levin : sündinud advokaadiks. [Tallinn] : Tammerraamat, 2009

Raamatureisid Veneetsiasse / Margus Haav

Index Scriptorium Estoniae

Haav, Margus, 1969-

2005-01-01

Arvustus: Girardi, Robert. Vaporetto 13 / ingl. k. tlk. Karin Suursalu. Tallinn : Kultuurileht, 2005. (Loomingu Raamatukogu) ; Raittila, Hannu. Canal Grande : [romaan] / tõlkinud Aivo Lõhmus. Tallinn : Varrak, 2003 (Moodne aeg)

Sajandilõpu noori autoreid : Kruoganist Urduni / Piret Viires

Index Scriptorium Estoniae

Viires, Piret, 1963-

1999-01-01

Arvustus: Kruogan / koost. Hedda Maurer. Tallinn : Vares, 1998 ; Hea raamat / NAK ; toim. Indrek Särg. Tartu : Eesti Kostabi Selts, 1998 ; Harakkiri. Tallinn : Erakkond, 1999 ; Urdu : [kirjanduslik kogumik]. Rewal, 1999

Keskkond / Peep Pobbul

Index Scriptorium Estoniae

Pobbul, Peep

2004-01-01

Ilmunud ka: 2003 : annual report : [Eesti Raudtee]. - Tallinn, 2004, lk. 40-41; 2003 : godovoi ottshjot : [Eesti Raudtee]. - Tallinn, 2004, lk. 40-41. AS-i Eesti Raudtee keskkonna-alastest projektidest

Õhuloss kuristiku kohal / Raul Sulbi

Index Scriptorium Estoniae

Sulbi, Raul

2002-01-01

Arvustus: Pelevin, Viktor. Sinine latern / vene keelest tõlkinud Vladimir Indrikson. Tallinn : Atlantis, 2002 ; Pelevin, Viktor. Omon Ra ; Generation "P" / vene keelest tõlkinud Maiga Varik. Tallinn : Varrak, 2002

A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest

Science.gov (United States)

Arenz, Stefan; Bock, Lars V.; Graf, Michael; Innis, C. Axel; Beckmann, Roland; Grubmüller, Helmut; Vaiana, Andrea C.; Wilson, Daniel N.

2016-07-01

Nascent polypeptides can induce ribosome stalling, regulating downstream genes. Stalling of ErmBL peptide translation in the presence of the macrolide antibiotic erythromycin leads to resistance in Streptococcus sanguis. To reveal this stalling mechanism we obtained 3.6-Å-resolution cryo-EM structures of ErmBL-stalled ribosomes with erythromycin. The nascent peptide adopts an unusual conformation with the C-terminal Asp10 side chain in a previously unseen rotated position. Together with molecular dynamics simulations, the structures indicate that peptide-bond formation is inhibited by displacement of the peptidyl-tRNA A76 ribose from its canonical position, and by non-productive interactions of the A-tRNA Lys11 side chain with the A-site crevice. These two effects combine to perturb peptide-bond formation by increasing the distance between the attacking Lys11 amine and the Asp10 carbonyl carbon. The interplay between drug, peptide and ribosome uncovered here also provides insight into the fundamental mechanism of peptide-bond formation.

Double crystal monochromator controlled by integrated computing on BL07A in New SUBARU, Japan

Energy Technology Data Exchange (ETDEWEB)

Okui, Masato, E-mail: okui@kohzu.co.jp [Kohzu Precision Co., Ltd., 2-6-15, Kurigi, Asao-ku, Kawasaki-shi, Kanagawa 215-8521 (Japan); Laboratory of Advanced Science and Technology for Industry, University of Hyogo (Japan); Yato, Naoki; Watanabe, Akinobu; Lin, Baiming; Murayama, Norio [Kohzu Precision Co., Ltd., 2-6-15, Kurigi, Asao-ku, Kawasaki-shi, Kanagawa 215-8521 (Japan); Fukushima, Sei, E-mail: FUKUSHIMA.Sei@nims.go.jp [Laboratory of Advanced Science and Technology for Industry, University of Hyogo (Japan); National Institute for Material Sciences (Japan); Kanda, Kazuhiro [Laboratory of Advanced Science and Technology for Industry, University of Hyogo (Japan)

2016-07-27

The BL07A beamline in New SUBARU, University of Hyogo, has been used for many studies of new materials. A new double crystal monochromator controlled by integrated computing was designed and installed in the beamline in 2014. In this report we will discuss the unique features of this new monochromator, MKZ-7NS. This monochromator was not designed exclusively for use in BL07A; on the contrary, it was designed to be installed at low cost in various beamlines to facilitate the industrial applications of medium-scale synchrotron radiation facilities. Thus, the design of the monochromator utilized common packages that can satisfy the wide variety of specifications required at different synchrotron radiation facilities. This monochromator can be easily optimized for any beamline due to the fact that a few control parameters can be suitably customized. The beam offset can be fixed precisely even if one of the two slave axes is omitted. This design reduces the convolution of mechanical errors. Moreover, the monochromator’s control mechanism is very compact, making it possible to reduce the size of the vacuum chamber can be made smaller.

Minocycline does not evoke anxiolytic and antidepressant-like effects in C57BL/6 mice.

Science.gov (United States)

Vogt, M A; Mallien, A S; Pfeiffer, N; Inta, I; Gass, P; Inta, D

2016-03-15

Minocycline is a broad-spectrum tetracycline antibiotic with multiple actions, including anti-inflammatory and neuroprotective effects, that was proposed as novel treatment for several psychiatric disorders including schizophrenia and depression. However, there are contradictory results regarding antidepressant effects of minocycline in rodent models. Additionally, the possible anxiolytic effect of minocycline is still poorly investigated. Therefore, we aimed to clarify in the present study the influence of minocycline on behavioral correlates of mood disorders in standard tests for depression and anxiety, the Porsolt Forced Swim Test (FST), Elevated O-Maze, Dark-Light Box Test and Openfield Test in adult C57BL/6 mice. We found, unexpectedly, that mice treated with minocycline (20-40mg/kg, i.p.) did not display antidepressant- or anxiolytic-like behavioral changes in contrast to mice treated with diazepam (0.5mg/kg, anxiety tests) or imipramine (20mg/kg, depressive-like behavior). These results are relevant for future studies, considering that C57BL/6 mice, the most widely used strain in pharmacological and genetic animal models, did not react as expected to the treatment regime applied. Copyright © 2015 Elsevier B.V. All rights reserved.

Melchior: Eesti tulevane ikoon / Jaan Martinson

Index Scriptorium Estoniae

Martinson, Jaan, 1960-

2010-01-01

Tutvustus: Hargla, Indrek, pseud. Apteeker Melchior ja Oleviste mõistatus : kriminaalromaan vanast Tallinnast. Tallinn : Varrak, 2010 ; Hargla, Indrek, pseud. Apteeker Melchior ja Rataskaevu viirastus : kriminaalromaan vanast Tallinnast. Tallinn : Varrak, 2010

Hingelised kriminaalid / Vaapo Vaher

Index Scriptorium Estoniae

Vaher, Vaapo, 1945-

1994-01-01

Raamatututvustus: Ränik, Valeria. Ajast väljas. Viljandi : Ajaleht "Sakala", 1994. Kallas, Aino. Pärjapunuja. Tallinn : Eesti Raamat, 1994. Wallace, Edgar. Kuldne iidol ; Kolme tamme saladus. Tallinn : Perioodika, 1994

Aegade varjud : [luuletused] / Karl Ast Rumor

Index Scriptorium Estoniae

Ast Rumor, Karl

2007-01-01

Sisu : Meie ja nemad ; Öisel teel ; Luikede laul ; Crescendo ; Needmine ; Bajazzo ; Kurbtus ; Minevikule ; Tunnistus ; Punased lilled. Varem ilmunud ""Edasi" jõulualbum 4". Tallinn 1911 ; "Meie Sõna 1". Tallinn 1911

Infotehnoloogiateenistus / Meelis Kukk

Index Scriptorium Estoniae

Kukk, Meelis

2004-01-01

Ilmunud ka: 2003 : annual report : [Eesti Raudtee]. - Tallinn, 2004, lk. 36; 2003 : godovoi ottshjot : [Eesti Raudtee]. - Tallinn, 2004, lk. 36. Ülevaade AS-i Eesti Raudtee infotehnoloogiteenistuse tegvusest 2003. aastal

Planeeringute uus veebiregister sai valmis

Index Scriptorium Estoniae

2015-01-01

Varasem register http://ehitus.tallinn.ee jääb projekteerimistingimuste ja ehitusprojektide jaoks, Tallinna uus planeeringute register http://tpr.tallinn.ee võimaldab kõigil huvitatutel linnaplaneerimises arvamust avaldada

An Analysis of Periodic Components in BL Lac Object S5 0716 +714 with MUSIC Method

Science.gov (United States)

Tang, J.

2012-01-01

Multiple signal classification (MUSIC) algorithms are introduced to the estimation of the period of variation of BL Lac objects.The principle of MUSIC spectral analysis method and theoretical analysis of the resolution of frequency spectrum using analog signals are included. From a lot of literatures, we have collected a lot of effective observation data of BL Lac object S5 0716 + 714 in V, R, I bands from 1994 to 2008. The light variation periods of S5 0716 +714 are obtained by means of the MUSIC spectral analysis method and periodogram spectral analysis method. There exist two major periods: (3.33±0.08) years and (1.24±0.01) years for all bands. The estimation of the period of variation of the algorithm based on the MUSIC spectral analysis method is compared with that of the algorithm based on the periodogram spectral analysis method. It is a super-resolution algorithm with small data length, and could be used to detect the period of variation of weak signals.

A thioacetamide-induced hepatic encephalopathy model in C57BL/6 mice: a behavioral and neurochemical study Modelo de encefalopatia hepática induzida por tioacetamida em camundongos C57BL/6: estudo comportamental e neuroquímico

Directory of Open Access Journals (Sweden)

Aline Silva de Miranda

2010-08-01

Full Text Available OBJECTIVE: Hepatic encephalopathy (HE is a neuropsychiatric syndrome resulting from liver failure. In the present study, we aimed to standardize an animal model of HE induced by thioacetamide (TAA in C57BL/6 mice evaluating behavioral symptoms in association with liver damage and alterations in neurotransmitter release. METHOD: HE was induced by an intraperitoneal single dose of TAA (200 mg/kg, 600 mg/kg or 1,200 mg/kg. Behavioral symptoms were evaluated using the SHIRPA battery. Liver damage was confirmed by histopathological analysis. The glutamate release was measured using fluorimetric assay. RESULTS: The neuropsychiatric state, motor behavior and reflex and sensory functions were significantly altered in the group receiving 600 mg/kg of TAA. Biochemical analysis revealed an increase in the glutamate release in the cerebral cortex of HE mice. CONCLUSION: HE induced by 600mg/kg TAA injection in C57BL/6 mice seems to be a suitable model to investigate the pathogenesis and clinical disorders of HE.OBJETIVO: A encefalopatia hepática (EH é uma síndrome neuropsiquiátrica resultante da falência hepática. O objetivo do presente estudo foi estabelecer um modelo de EH induzida por tioacetamida (TAA em camundongos C57BL/6 avaliando transtornos comportamentais, falência hepática e alterações na liberação de neurotransmissores. MÉTODO: A EH foi induzida por meio de uma única dose intraperitoneal de TAA (200 mg/kg, 600 mg/kg, 1.200 mg/kg. As alterações comportamentais foram avaliadas utilizando a bateria SHIRPA. A falência hepática foi confirmada através de análises histopatológicas e a liberação de glutamato medida, por ensaio fluorimétrico. RESULTADOS: Foram encontradas alterações significativas no estado neuropsiquiátrico, comportamento motor e função reflexa e sensorial no grupo que recebeu 600 mg/kg de TAA. Análises bioquímicas revelaram aumento na liberação de glutamato no córtex cerebral dos camundongos com EH

Acupuncture of Weizhong (BL 40) and Zusanli (ST 36) on the study of brain function by PET/CT imaging

International Nuclear Information System (INIS)

Shao Guangrui; Chen Ying; Yan Bin; Liu Cheng; Wang Guangcai; Tan Qiwen

2006-01-01

Objective: To explore the correlation between acupuncture of the points and certain functional areas of brain by PET/CT imaging. Methods: Twelve healthy volunteers were acupunctured separately in the point Weizhong (BL 40, right leg) and Zusanli(ST 36, right leg), and 5 consecutive PET/CT images were taken, statistical parameter map (SPM) paired t-test was analyzed between the different activated brain PET/CT imagings. Results: Changes of PET/CT imaging were found in acupuncture of the point Weizhong (BL 40) and Zusanli(ST 36) in 12 healthy volunteers. High metabolic areas were demonstrated in multiple brain regions, the data of two groups had significant difference between 2 points (t>4.03, P< 0.01). Conclusion: Acupuncturing the different point resulted activation of the glucose metabolism in different brain areas. (authors)

Majaraamatud - ühtne tervik ja väärikalt hoitud detailid / Yoko Alender

Index Scriptorium Estoniae

Alender, Yoko, 1979-

2011-01-01

Tutvustus: Tallinna maja : hoonetüübi areng ja säästev uuendamine / koostanud Mark Sepp ja Tallinna Kultuuriväärtuste Amet. Tallinn, 2010; Lenderi maja : hoonetüübi areng ja säästev uuendamine / koostanud Anni Martin ja Tallinna Kultuuriväärtuste Amet. Tallinn, 2009; Funktsionalistlik maja : eramu ja väike kortermaja / koostanud Monika Eensalu ja Tallinna Kultuuriväärtuste Amet. Tallinn, 2011. Vanade majade säilitamisest

Tõlkimise teooriast ja praktikast / Märt Väljataga

Index Scriptorium Estoniae

Väljataga, Märt, 1965-

2008-01-01

Tõlkimisest ja tõlkekriitikast. 2008. a. ilmunud tõlkimist käsitlevatest väljaannetest: Lange, Anne. Tõlkimise aabits. Tallinn : Valgus, 2008 ; Saluäär, Anu. Põhjamaadest ja Eestist. Tallinn : Eesti Keele Sihtasutus, 2008 ; Kaldjärv, Klaarika. Autor, jutustaja, tõlkija : Borgese autofiktsioonid eesti keeles. Tartu : Tartu Ülikooli Kirjastus, 2008 ; Ain Kaalep 80 : konverentsikogumik. Tartu : Eesti Kirjanduse Selts, 2008. (Eesti Kirjanduse Seltsi aastaraamat 2006 ; 32) ; Steiner, George. Valik esseid / tlk. Triinu Pakk. Tallinn : Kultuurileht, 2008

Tracce, scambi, interpretazioni ed eredità. Analisi dei legami tra il Nordisk Teaterlaboratorium e l'America latina

Directory of Open Access Journals (Sweden)

Arianna Berenice De Sanctis

2016-04-01

Full Text Available Odin Teatret formed in 1964. This international theater group first began its activities in Norway and then moved to Denmark. In the course of its long and valuable existence, this group has established a network of contacts throughout the world and, from the 1970s onward began focusing on developing its contacts in Latin America. These particular relations provide the structural key to understanding the theory and praxis characteristic of Odin. The encounter with Latin America proved decisive in shaping the political and aesthetic thinking of Eugenio Barba, for whom the theater would remain the favored means of exploring this part of the world. Moreover, the communitarian and familial structure of the Odin, its predilection for the ceremonial, its artisanal dimension, its obsession with «memory» and «commemoration» align themselves with the interests and concerns of many Latin American artists and these have insured the survival of this ensemble through the present day (2014, half a century after its inception. Throughout its many tours on the Latin American continent, Odin Teatret has been more famous for its meta-theatrical activities than for its productions, organizing conferences, encounters, seminars, master classes, trocs, and video projections, while at the same time developing significantly its publishing activities. Given that this network is based both on former and current relationships, whether established or exploratory, born at very different times and places, this current study aims to provide a micro-history of these in order highlight the meaning and design in the choices and activities implemented by the Danish group. This case study of an exemplary phenomenon in international theater in the 20th century allows us to better understand and contextualize the evolution of contemporary live theater.

[Paulo Coelho. Zahir ; Jan Kaus. Tema] / Aarne Biin

Index Scriptorium Estoniae

Biin, Aarne

2007-01-01

Tutvustus: Coelho, Paulo. Zahir : [romaan] / portugali keelest tõlkinud Anneli Tuulik, [Konstantinos Kavafise luuletuse uuskreeka keelest tõlkinud Mati Sirkel. Tallinn] : Pilgrim Group, 2005 ; Kaus, Jan. Tema : [romaan]. Tallinn : Tuum, 2006

Kasulikud raamatud lastega reisijatele / Lydia Aspen

Index Scriptorium Estoniae

Aspen, Lydia

2009-01-01

Tutvustus: London : laste reisijuht : suurlinna seiklused, mõistatused ja mängud. Tallinn : TEA Kirjastus, 2009 ; Pariis : laste reisijuht : suurlinna seiklused, mõistatused ja mängud. Tallinn : TEA Kirjastus, 2009

Kolm plaati eesti klassikast : Cyrillus Kreegi "Requiemi" kaks ettekanet ja "Eesti heliloojad V" / Kerri Kotta

Index Scriptorium Estoniae

Kotta, Kerri, 1969-

2009-01-01

Arvustus : Kreek, Cyrillus. Requiem. Musica sacra. Tampere : Alba, 2007. Kreek, Cyrillus. Requiem. Tõnu Kõrvits. Kreegi vihik. [Tallinn] : Eesti Filharmoonia Kammerkoor, 2008. Eesti heliloojad V. Tallinn : Eesti Rahvusringhääling, 2008

Characterization of the CD8+ T cell responses directed against respiratory syncytial virus during primary and secondary infection in C57BL/6 mice

International Nuclear Information System (INIS)

Lukens, Michael V.; Claassen, Erwin A.W.; Graaff, Patricia M.A. de; Dijk, Mariska E.A. van; Hoogerhout, Peter; Toebes, Mireille; Schumacher, Ton N.; Most, Robbert G. van der; Kimpen, Jan L.L.; Bleek, Grada M. van

2006-01-01

The BALB/c mouse model for human respiratory syncytial virus infection has contributed significantly to our understanding of the relative role for CD4 + and CD8 + T cells to immune protection and pathogenic immune responses. To enable comparison of RSV-specific T cell responses in different mouse strains and allow dissection of immune mechanisms by using transgenic and knockout mice that are mostly available on a C57BL/6 background, we characterized the specificity, level and functional capabilities of CD8 + T cells during primary and secondary responses in lung parenchyma, airways and spleens of C57BL/6 mice. During the primary response, epitopes were recognized originating from the matrix, fusion, nucleo- and attachment proteins, whereas the secondary response focused predominantly on the matrix epitope. C57BL/6 mice are less permissive for hRSV infection than BALB/c mice, yet we found CD8 + T cell responses in the lungs and bronchoalveolar lavage, comparable to the responses described for BALB/c mice

Toxicity assessment of perfluorooctane sulfonate using acute and subchronic male C57BL/6J mouse models

International Nuclear Information System (INIS)

Xing, Jiali; Wang, Gang; Zhao, Jichun; Wang, Eryin; Yin, Boxing; Fang, Dongsheng; Zhao, Jianxin; Zhang, Hao; Chen, Yong Q.; Chen, Wei

2016-01-01

Perfluorooctane sulfonate (PFOS) is a principal representative and the final degradation product of several commercially produced perfluorinated compounds. However, PFOS has a high bioaccumulation potential and therefore can exert toxicity on aquatic organisms, animals, and cells. Considering the widespread concern this phenomenon has attracted, we examined the acute and subchronic toxic effects of varying doses of PFOS on adult male C57BL/6 mice. The acute oral LD_5_0 value of PFOS in male C57BL/6J mice was 0.579 g/kg body weight (BW). Exposure to the subchronic oral toxicity of PFOS at 2.5, 5, and 10 mg PFOS/kg BW/day for 30 days disrupted the homeostasis of antioxidative systems, induced hepatocellular apoptosis (as revealed by the terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assay), triggered liver injury (as evidenced by the increased serum levels of aspartate aminotransferase, alanine amino transferase, alkaline phosphatase, and gamma-glutamyl transpeptidase and by the altered histology), and ultimately increased the liver size and relative weight of the mice. PFOS treatment caused liver damage but only slightly affected the kidneys and spleen of the mice. This study provided insights into the toxicological effects of PFOS. - Highlights: • The acute and subchronic toxicity of PFOS was systematically investigated. • The acute oral LD_5_0 value for PFOS in C57BL/6J mice was 0.579 g/kg body weight. • PFOS disrupted the homeostasis of antioxidative systems. • PFOS induced hepatocellular apoptosis and triggered liver injury. - PFOS disrupted the homeostasis of antioxidative systems, induced hepatocellular apoptosis, and triggered liver injury.

A high density physical map of chromosome 1BL supports evolutionary studies, map-based cloning and sequencing in wheat

Czech Academy of Sciences Publication Activity Database

Philippe, R.; Paux, E.; Bertin, I.; Sourdille, P.; Choulet, F.; Laugier, Ch.; Šimková, Hana; Šafář, Jan; Bellec, A.; Vautrin, S.; Frenkel, Z.; Cattonaro, F.; Magni, F.; Scalabrin, S.; Martis, M.M.; Mayer, K. F. X.; Korol, A.; Berges, H.; Doležel, Jaroslav; Feuillet, C.

2013-01-01

Roč. 14, č. 6 (2013) ISSN 1465-6906 Institutional research plan: CEZ:AV0Z50380511 Keywords : chromosome 1BL * evolution * gene space Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 10.465, year: 2013

Uss uuristab inimese südame kallal / Kärt Hellerma

Index Scriptorium Estoniae

Hellerma, Kärt, 1956-

2003-01-01

Arvustus: [Õnnepalu, Tõnu] Tode, Emil. Raadio. Tallinn : Eesti Keele Sihtasutus, 2002. Ilmunud ka kogumikus: Hellerma, Kärt. Kohanenud kirjandus : valik kirjanduskriitikat 1987-2006. Eesti Keele Sihtasutus : Tallinn, 2006. Lk. 47-53

Ametnikule kohustuslik! / Siim Sukles

Index Scriptorium Estoniae

Sukles, Siim

2007-01-01

Rets. rmt: Lynn, Jonathan, Jay, Anthony. Jah, härra minister / tlk. Juhan Kahk. Tallinn : Varrak, 2007 ; Lynn, Jonathan, Jay, Anthony. Jah, härra peaminister / tlk. Juhan Kahk. Tallinn : Varrak, 2007