WorldWideScience

Sample records for tabizgar-e shekl-e tep

  1. Marine bacterial transparent exopolymer particles (TEP) and TEP precursors: Characterization and RO fouling potential

    KAUST Repository

    Li, Sheng

    2015-10-31

    This paper investigated the characteristics and membrane fouling potential of bacterial transparent exopolymer particles (TEP)/TEP precursors released from two marine bacteria, Pseudidiomarina homiensis (P. homiensis) and Pseudoalteromonas atlantica (P. atlantica), isolated from the Red Sea. Results showed that both bacteria grew at the similar rate, but the production of TEP/TEP precursors from P. atlantica was higher than that from P. homiensis. During the 168. h of incubation time, production rates of TEP/TEP precursors from P. atlantica and P. homiensis were 0.30 and 0.08 xanthan gum eq. mg/L-h, respectively. Isolated bacterial TEP precursors were mainly biopolymer, and P. atlantica produced a significantly higher concentration of biopolymer than that produced by P. homiensis. TEP/TEP precursors from both marine bacteria possessed protein-like material and were very similar in composition to previously reported foulants isolated from a fouled reverse osmosis (RO) membrane. Bacterial TEP/TEP precursors mostly consisted of aliphatic hydrocarbon from amino acids and amide group carbon of proteins (around 55%). Bacterial TEP precursors caused obvious fouling on RO membranes, which may create an ideal environment for bacteria attachment and promote to biofouling.

  2. TEP Power Partners Project [Tucson Electric Power

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2014-02-06

    The Arizona Governor’s Office of Energy Policy, in partnership with Tucson Electric Power (TEP), Tendril, and Next Phase Energy (NPE), formed the TEP Power Partners pilot project to demonstrate how residential customers could access their energy usage data and third party applications using data obtained from an Automatic Meter Reading (AMR) network. The project applied for and was awarded a Smart Grid Data Access grant through the U.S. Department of Energy. The project participants’ goal for Phase I is to actively engage 1,700 residential customers to demonstrate sustained participation, reduction in energy usage (kWh) and cost ($), and measure related aspects of customer satisfaction. This Demonstration report presents a summary of the findings, effectiveness, and customer satisfaction with the 15-month TEP Power Partners pilot project. The objective of the program is to provide residential customers with energy consumption data from AMR metering and empower these participants to better manage their electricity use. The pilot recruitment goals included migrating 700 existing customers from the completed Power Partners Demand Response Load Control Project (DRLC), and enrolling 1,000 new participants. Upon conclusion of the project on November 19, 2013; 1,390 Home Area Networks (HANs) were registered; 797 new participants installed a HAN; Survey respondents’ are satisfied with the program and found value with a variety of specific program components; Survey respondents report feeling greater control over their energy usage and report taking energy savings actions in their homes after participating in the program; On average, 43 % of the participants returned to the web portal monthly and 15% returned weekly; and An impact evaluation was completed by Opinion Dynamics and found average participant savings for the treatment period1 to be 2.3% of their household use during this period.2 In total, the program saved 163 MWh in the treatment period of 2013.

  3. Prochlorococcus as a Possible Source for Transparent Exopolymer Particles (TEP)

    KAUST Repository

    Agusti, Susana

    2017-04-26

    Transparent exopolymer particles (TEP), usually associated with phytoplankton blooms, promote the formation of marine aggregates. Their exportation to deep waters is considered a key component of the biological carbon pump. Here, we explored the role of solar radiation and picocyanobacteria in the formation of TEP in oligotrophic surface waters of the Atlantic and Pacific Oceans in ten on-deck incubation experiments during the Malaspina 2010 Expedition. TEP concentrations were low on the ocean’s surface although these concentrations were significantly higher on the surface of the Pacific (24.45 ± 2.3 μg XG Eq. L-1) than on the surface of the Atlantic Ocean (8.18 ± 4.56 μg XG Eq. L-1). Solar radiation induced a significant production of TEP in the on-deck experiments from the surface water of the Pacific Ocean, reaching values up to 187.3 μg XG Eq. L-1 compared with the low production observed in the dark controls. By contrast, TEP production in the Atlantic Ocean experiments was lower, and its formation was not related to the light treatments. Prochlorococcus sp. from the surface ocean was very sensitive to solar radiation and experienced a high cell decay in the Pacific Ocean experiments. TEP production in the on-deck incubation experiments was closely related to the observed cell decay rates of Prochlorococcus sp., suggesting that this picocyanobacteria genus is a potential source of TEP. The evidence to propose such potential role was derived experimentally, using natural communities including the presence of several species and a variety of processes. Laboratory experiments with cultures of a non-axenic strain of Prochlorococcus marinus were then used to test TEP production by this genus. TEP concentrations in the culture increased with increasing cell abundance during the exponential phase, reaching the highest TEP concentration at the beginning of the stationary phase. The average TEP concentration of 1474 ± 226 μg XG Eq. L-1 (mean ± SE) observed at

  4. Effectiveness of seawater reverse osmosis (SWRO) pretreatment systems in removing transparent exopolymer particles (TEP) substances

    KAUST Repository

    Lee, Shang-Tse

    2015-05-01

    Transparent exopolymer particles (TEP) have been reported as one of the main factors of membrane fouling in seawater reverse osmosis (SWRO) process. Research has been focused on algal TEP so far, overlooking bacterial TEP. This thesis investigated the effects of coagulation on removal of bacterial TEP/TEP precursors in seawater and subsequent reduction on TEP fouling in ultrafiltration (UF), as a pretreatment of SWRO. Furthermore, the performance of pretreatment (coagulation + UF) has been investigated on a bench-scale SWRO system. TEP/TEP precursors were harvested from a strain of marine bacteria, Pseudoalteromonas atlantica, isolated from the Red Sea. Isolated bacterial organic matter (BOM), containing 1.5 mg xanthan gum eq./L TEP/TEP precursors, were dosed in Red Sea water to mimic a high TEP concentration event. Bacterial TEP/TEP precursors added to seawater were coagulated with ferric chloride and aluminum sulfate at different dosages and pH. Results showed that ferric chloride had a better removal efficiency on TEP/TEP precursors. Afterwards, the non-coagulated/coagulated seawater were tested on a UF system at a constant flux of 130 L/m2h, using two types of commercially available membranes, with pore sizes of 50 kDa and 100 kDa, respectively. The fouling potential of coagulated water was determined by the Modified Fouling Index (MFI-UF). Transmembrane pressure (TMP) was also continuously monitored to investigate the fouling development on UF membranes. TEP concentrations in samples were determined by the alcian blue staining assay. Liquid chromatography-organic carbon detection (LC-OCD) was used to determine the removal of TEP precursors with particular emphasis on biopolymers. Finally, SWRO tests showed that TEP/TEP precursors had a high fouling potential as indicated by MFI-UF, corresponding to the TMP measurements. Coagulation could substantially reduce TEP/TEP precursors fouling in UF when its dosage was equal or higher than 0.2 mg Fe/L. The flux decline

  5. Toroidal Energy Principle (TEP) and perturbed equilibrium code STB

    Science.gov (United States)

    Zakharov, Leonid; Hu, Di

    2016-10-01

    The MHD energy principle TEP is presented in terms of perturbations of the vector potential, rather than plasma displacement. This form makes TEP capable to discribe both the ideal plasmas stability and the perturbed equilibria. The functional is expressed in two terms. The first one represents the energy of magnetic field and is calculated using working equilibrium coordinate system. The second term, containing plasma displacement is expressed in the compact form using Hamada coordinates. This representation uses the same combinations of metric coefficients as in the equilibrium calculations. The STB code implements the TEP for both ideal MHD and perturbed equilibria. In the first case, it uses the matching conditions of the ideal MHD. In the second case, the 2-D equilibrium islands are introduced in order to resolve the singularity and match the solutions across the resonant surfaces Partially by (a) US DoE Contract No. DE-AC02-09-CH11466, (b) General Fusion Inc.

  6. Transgenic Expression of the Anti-parasitic Factor TEP1 in the Malaria Mosquito Anopheles gambiae.

    Science.gov (United States)

    Volohonsky, Gloria; Hopp, Ann-Katrin; Saenger, Mélanie; Soichot, Julien; Scholze, Heidi; Boch, Jens; Blandin, Stéphanie A; Marois, Eric

    2017-01-01

    Mosquitoes genetically engineered to be resistant to Plasmodium parasites represent a promising novel approach in the fight against malaria. The insect immune system itself is a source of anti-parasitic genes potentially exploitable for transgenic designs. The Anopheles gambiae thioester containing protein 1 (TEP1) is a potent anti-parasitic protein. TEP1 is secreted and circulates in the mosquito hemolymph, where its activated cleaved form binds and eliminates malaria parasites. Here we investigated whether TEP1 can be used to create malaria resistant mosquitoes. Using a GFP reporter transgene, we determined that the fat body is the main site of TEP1 expression. We generated transgenic mosquitoes that express TEP1r, a potent refractory allele of TEP1, in the fat body and examined the activity of the transgenic protein in wild-type or TEP1 mutant genetic backgrounds. Transgenic TEP1r rescued loss-of-function mutations, but did not increase parasite resistance in the presence of a wild-type susceptible allele. Consistent with previous reports, TEP1 protein expressed from the transgene in the fat body was taken up by hemocytes upon a challenge with injected bacteria. Furthermore, although maturation of transgenic TEP1 into the cleaved form was impaired in one of the TEP1 mutant lines, it was still sufficient to reduce parasite numbers and induce parasite melanization. We also report here the first use of Transcription Activator Like Effectors (TALEs) in Anopheles gambiae to stimulate expression of endogenous TEP1. We found that artificial elevation of TEP1 expression remains moderate in vivo and that enhancement of endogenous TEP1 expression did not result in increased resistance to Plasmodium. Taken together, our results reveal the difficulty of artificially influencing TEP1-mediated Plasmodium resistance, and contribute to further our understanding of the molecular mechanisms underlying mosquito resistance to Plasmodium parasites.

  7. Transgenic Expression of the Anti-parasitic Factor TEP1 in the Malaria Mosquito Anopheles gambiae.

    Directory of Open Access Journals (Sweden)

    Gloria Volohonsky

    2017-01-01

    Full Text Available Mosquitoes genetically engineered to be resistant to Plasmodium parasites represent a promising novel approach in the fight against malaria. The insect immune system itself is a source of anti-parasitic genes potentially exploitable for transgenic designs. The Anopheles gambiae thioester containing protein 1 (TEP1 is a potent anti-parasitic protein. TEP1 is secreted and circulates in the mosquito hemolymph, where its activated cleaved form binds and eliminates malaria parasites. Here we investigated whether TEP1 can be used to create malaria resistant mosquitoes. Using a GFP reporter transgene, we determined that the fat body is the main site of TEP1 expression. We generated transgenic mosquitoes that express TEP1r, a potent refractory allele of TEP1, in the fat body and examined the activity of the transgenic protein in wild-type or TEP1 mutant genetic backgrounds. Transgenic TEP1r rescued loss-of-function mutations, but did not increase parasite resistance in the presence of a wild-type susceptible allele. Consistent with previous reports, TEP1 protein expressed from the transgene in the fat body was taken up by hemocytes upon a challenge with injected bacteria. Furthermore, although maturation of transgenic TEP1 into the cleaved form was impaired in one of the TEP1 mutant lines, it was still sufficient to reduce parasite numbers and induce parasite melanization. We also report here the first use of Transcription Activator Like Effectors (TALEs in Anopheles gambiae to stimulate expression of endogenous TEP1. We found that artificial elevation of TEP1 expression remains moderate in vivo and that enhancement of endogenous TEP1 expression did not result in increased resistance to Plasmodium. Taken together, our results reveal the difficulty of artificially influencing TEP1-mediated Plasmodium resistance, and contribute to further our understanding of the molecular mechanisms underlying mosquito resistance to Plasmodium parasites.

  8. Dynamics of transparent exopolymeric particles (TEP) and particle ...

    Indian Academy of Sciences (India)

    Unlike CPCHO, Sal-PCHO concentrations showed a positive trend with Chl a and significant linear correlation with bacterial abundance. (r = 0.44,p< 0.007, n = 48), indicating that Sal-PCHO as carbon source might have supported bacterioplankton abundance. The mean %TEP-C contribution to the annual average organic ...

  9. The evolution of TEP1, an exceptionally polymorphic immunity gene in Anopheles gambiae

    Directory of Open Access Journals (Sweden)

    Yan Guiyun

    2008-10-01

    Full Text Available Abstract Background Host-parasite coevolution can result in balancing selection, which maintains genetic variation in the susceptibility of hosts to parasites. It has been suggested that variation in a thioester-containing protein called TEP1 (AGAP010815 may alter the ability of Anopheles mosquitoes to transmit Plasmodium parasites, and high divergence between alleles of this gene suggests the possible action of long-term balancing selection. We studied whether TEP1 is a case of an ancient balanced polymorphism in an animal immune system. Results We found evidence that the high divergence between TEP1 alleles is the product of genetic exchange between TEP1 and other TEP loci, i.e. gene conversion. Additionally, some TEP1 alleles showed unexpectedly low variability. Conclusion The TEP1 gene appears to be a chimera produced from at least two other TEP loci, and the divergence between TEP1 alleles is probably not caused by long-term balancing selection, but is instead due to two independent gene conversion events from one of these other genes. Nevertheless, TEP1 still shows evidence of natural selection, in particular there appears to have been recent changes in the frequency of alleles that has diminished polymorphism within each allelic class. Although the selective force driving this dynamic was not identified, given that susceptibility to Plasmodium parasites is known to be associated with allelic variation in TEP1, these changes in allele frequencies could alter the vectoring capacity of populations.

  10. Abundance, size distribution and bacterial colonization of transparent exopolymeric particles (TEP) during spring in the Kattegat

    DEFF Research Database (Denmark)

    Mari, X.; Kiørboe, Thomas

    1996-01-01

    The abundance, size distribution and bacterial colonization of transparent exopolymeric particles (TEP) were monitored in the Kattegat (Denmark) at weekly intervals throughout the spring (February-May) encompassing the spring diatom bloom. These recently discovered particles are believed to be fo......The abundance, size distribution and bacterial colonization of transparent exopolymeric particles (TEP) were monitored in the Kattegat (Denmark) at weekly intervals throughout the spring (February-May) encompassing the spring diatom bloom. These recently discovered particles are believed...... of beta differed significantly from three, probably because TEP are fractal. All TEP were colonized by bacteria, and bacteria were both attached to the surface of and embedded in TEP. Yet the number of attached bacteria per TEP was related neither to the surface area nor the volume, but rather scaled...

  11. Seasonal size spectra of transparent exopolymeric particles (TEP) in a coastal sea and comparison with those predicted using coagulation theory

    DEFF Research Database (Denmark)

    Mari, Xavier; Burd, A

    1998-01-01

    the spring bloom and again during the summer period. The observed accumulation of TEP during summer is consistent with the recent observation that dissolved organic matter (DOM) concentration has a similar seasonal distribution and suggests that TEP are formed from DOM. The supposed mode of formation of TEP...... generated by the model were fitted to the observed TEP size spectra. The spectra predicted from the model fitted the observations relatively well, suggesting that the model provides a good description of the kinetics of TEP coagulation and that coagulation of colloids is an important mode of TEP formation...

  12. Compositional Similarities and Differences between Transparent Exopolymer Particles (TEP) from two Marine Bacteria and two Marine Algae: Significance to Surface Biofouling

    KAUST Repository

    Li, Sheng

    2015-06-12

    Transparent-exopolymer-particles (TEP) have been recently identified as a significant contributor to surface biofouling, such as on reverse osmosis (RO) membranes. TEP research has mainly focused on algal TEP/TEP precursors while limited investigations have been conducted on those released by bacteria. In this study, TEP/TEP precursors derived from both algae and bacteria were isolated and then characterized to investigate their similarities and/or differences using various advanced analytical techniques, thus providing a better understanding of their potential effect on biofouling. Bacterial TEP/TEP precursors were isolated from two species of marine bacteria (Pseudidiomarina homiensis and Pseudoalteromonas atlantica) while algal TEP/TEP precursors were isolated from two marine algae species (Alexandrium tamarense and Chaetoceros affinis). Results indicated that both isolated bacterial and algal TEP/TEP precursors were associated with protein-like materials, and most TEP precursors were high-molecular-weight biopolymers. Furthermore all investigated algal and bacterial TEP/TEP precursors showed a lectin-like property, which can enable them to act as a chemical conditioning layer and to agglutinate bacteria. This property may enhance surface biofouling. However, both proton nuclear magnetic resonance (NMR) spectra and the nitrogen/carbon (N/C) ratios suggested that the algal TEP/TEP precursors contained much less protein content than the bacterial TEP/TEP precursors. This difference may influence their initial deposition and further development of surface biofouling.

  13. Evaluation of potential particulate/colloidal TEP foulants on a pilot scale SWRO desalination study

    KAUST Repository

    Li, Sheng

    2016-01-21

    This pilot study investigated the variation of potential foulants and different fractions of transparent exopolymer particles (TEP), along the treatment scheme under different conditions. The objectives are to provide a comprehensive understanding on which fraction of TEP is more problematic in seawater reverse osmosis (SWRO) fouling, and which pretreatment can better reduce the concentration of TEP. Results showed that TEP deposited on the RO membranes, and the extent of RO fouling increased with the increase of TEP concentration in RO feed water. More TEP was produced in water after chlorination, probably because of the breakdown of bacterial cells and thus the release of internal exopolymers. Moreover, the cartridge filters could behave as an incubator for the regrowth of bacteria deactivated by chlorination and a spot for potential foulant (bacterial TEP) production, and thus enhance the RO membranes fouling. The presence of residual iron and addition of phosphate based antiscalant may also contribute to the higher biofouling of RO membranes. This pilot study provided an opportunity to identify the TEP related issues under different operational conditions in RO desalination of Red Sea water.

  14. Chronic pain after TEP inguinal hernia repair, does MRI reveal a cause?

    NARCIS (Netherlands)

    Burgmans, J. P J; Voorbrood, C. E H; Van Dalen, T.; Boxhoorn, R. N.; Clevers, G. J.; Sanders, F. B M; Naafs, D. B J; Simmermacher, R. K J

    2016-01-01

    Purpose: Persistent pain is a known side effect after TEP inguinal repair disabling 2–5 % of patients. A standardized diagnostic work-up so far is not available. MRI is a diagnostic tool in the work-up of inguinal hernias. In the present study the yield of MRI in evaluating chronic pain after TEP

  15. Abundance of thraustochytridsand bacteria in the equatorial Indian Ocean, in relation totransparent exopolymeric particles (TEPs)

    Digital Repository Service at National Institute of Oceanography (India)

    Damare, V.; Raghukumar

    related to TEPs generated from in situ water in a roller table experiment. TEPs from natural samples during October 2004 had a much greater affinity to the lectin Concanavalin A than to Limulin compared with those in September 2006 and from the roller tank...

  16. Improved method for measuring transparent exopolymer particles (TEP) and their precursors infresh and saline water

    KAUST Repository

    Villacorte, Loreen O.

    2015-03-01

    Transparent exopolymer particles (TEP) and their precursors produced by phyto-/bacterio-planktons in fresh and marine aquatic environments are increasingly considered as a major contributor to organic/particulate and biological fouling in micro-/ultra-filtration and reverse osmosis membrane (RO) systems. However, currently established methods which are based on Alcian blue (AB) staining and spectrophotometric techniques do not measure TEP-precursors and have the tendency to overestimate concentration in brackish/saline water samples due to interference of salinity on AB staining. Here we propose a new semi-quantitative method which allows measurement of both TEP and their colloidal precursors without the interference of salinity. TEP and their precursors are first retained on 10kDa membrane, rinsed with ultra-pure water, and re-suspended in ultra-pure water by sonication and stained with AB, followed by exclusion of TEP-AB precipitates by filtration and absorbance measurement of residual AB. The concentration is then determined based on the reduction of AB absorbance due to reaction with acidic polysaccharides, blank correction and calibration with Xanthan gum standard. The extraction procedure allows concentration of TEP and their pre-cursors which makes it possible to analyse samples with a wide range of concentrations (down to <0.1mg Xeq/L). This was demonstrated through application of the method for monitoring these compounds in algal cultures and a full-scale RO plant. The monitoring also revealed that concentrations of the colloidal precursors were substantially higher than the concentration of TEP themselves. In the RO plant, complete TEP removal was observed over the pre-treatment processes (coagulation-sedimentation-filtration and ultrafiltration) but the TEP precursors were not completely removed, emphasising the importance of measuring this colloidal component to better understand the role of TEP and acidic polysaccharides in RO membrane fouling.

  17. TEP1, the yeast homolog of the human tumor suppressor gene PTEN/MMAC1/TEP1, is linked to the phosphatidylinositol pathway and plays a role in the developmental process of sporulation.

    Science.gov (United States)

    Heymont, J; Berenfeld, L; Collins, J; Kaganovich, A; Maynes, B; Moulin, A; Ratskovskaya, I; Poon, P P; Johnston, G C; Kamenetsky, M; DeSilva, J; Sun, H; Petsko, G A; Engebrecht, J

    2000-11-07

    PTEN/MMAC1/TEP1 (PTEN, phosphatase deleted on chromosome ten; MMAC1, mutated in multiple advanced cancers; TEP1, tensin-like phosphatase) is a major human tumor suppressor gene whose suppressive activity operates on the phosphatidylinositol pathway. A single homologue of this gene, TEP1 (YNL128w), exists in the budding yeast Saccharomyces cerevisiae. Yeast strains deleted for TEP1 exhibit essentially no phenotype in haploids; however, diploids exhibit resistance to the phosphatidylinositol-3-phosphate kinase inhibitor wortmannin and to lithium ions. Although rates of cancer increase with age, neither tep1 haploids nor diploids have altered life spans. TEP1 RNA is present throughout the cell cycle, and levels are dramatically up-regulated during meiotic development. Although homozygous tep1 mutants initiate the meiotic program and form spores with wild-type kinetics, analysis of the spores produced in tep1 mutants indicates a specific defect in the trafficking or deposition of dityrosine, a major component of yeast spore walls, to the surface. Introduction of a common PTEN mutation found in human tumors into the analogous position in Tep1p produces a nonfunctional protein based on in vivo activity. These studies implicate Tep1p in a specific developmental trafficking or deposition event and suggest that Tep1p, like its mammalian counterpart, impinges on the phosphatidylinositol pathway.

  18. Comparison of Alcian blue and total carbohydrate assays for quantitation of transparent exopolymer particles (TEP) in biofouling studies.

    Science.gov (United States)

    Li, Xu; Skillman, Lucy; Li, Dan; Ela, Wendell P

    2018-04-15

    Transparent exopolymer particles (TEP) and their precursors are gel-like acidic polysaccharide particles. Both TEP precursors and TEP have been identified as causal factors in fouling of desalination and water treatment systems. For comparison between studies, it is important to accurately measure the amount and fouling capacity of both components. However, the accuracy and recovery of the currently used Alcian blue based TEP measurement of different surrogates and different size fractions are not well understood. In this study, we compared Alcian blue based TEP measurements with a total carbohydrate assay method. Three surrogates; xanthan gum, pectin and alginic acid; were evaluated at different salinities. Total carbohydrate concentrations of particulates (>0.4 μm) and their precursors (10 kDa) varied depending on water salinity and method of recovery. As xanthan gum is the most frequently used surrogate in fouling studies, TEP concentration is expressed as xanthan gum equivalents (mg XG eq /L) in this study. At a salinity of 35 mg/L sea salt, total carbohydrate assays showed a much higher particulate TEP fraction for alginic acid (38%) compared to xanthan gum (9%) and pectin (12%). The concentrations of particulate TEP therefore may only represent ∼10% of the total mass; while precursor TEP represents ∼80% of the total TEP. This highlights the importance of reporting both particulate and precursor TEP for membrane biofouling studies. The calculated concentrations of TEP and their precursors in seawater samples are also highly dependent on type of surrogate and resulting calibration factor. A linear correlation between TEP recovery and calibration factor was demonstrated in this study for all three surrogates. The relative importance and accuracy of measurement method, particulate size, surrogate type, and recovery are described in detail in this study. Copyright © 2017. Published by Elsevier Ltd.

  19. A comparative study of standard versus laparoendoscopic single-site surgery (LESS) totally extraperitoneal (TEP) inguinal hernia repair.

    Science.gov (United States)

    Tai, Huai-Ching; Lin, Chia-Da; Chung, Shiu-Dong; Chueh, Shih-Chieh Jeff; Tsai, Yao-Chou; Yang, Stephen Shei-Dei

    2011-09-01

    Laparoscopic inguinal hernia repair has been around since the 1990s. A novel surgical approach known as laparoendoscopic single-site surgery (LESS) has been developed to reduce the port-related morbidities and improve the cosmetic outcomes of laparoscopic surgery, including totally extraperitoneal (TEP) inguinal hernia repair. The aim of the present study was to evaluate the safety and feasibility of the LESS TEP technique for inguinal hernia repair and compare the outcomes with the standard TEP approach. Between January and May 2009, 54 consecutive healthy patients (48 men and 6 women) underwent LESS TEP inguinal hernia repair at our institute. All procedures were performed using our homemade single port for simultaneous passage of the laparoscope and instruments. The perioperative data, including patient age, sex, body mass index (BMI), hernia characteristics, operative time, complications, length of hospital stay, return to normal activity, pain score, and cosmetic result, were prospectively collected. All LESS TEP procedures were completed successfully without conversion to standard laparoscopic or open surgery. A total of 98 LESS TEP hernia repairs were performed in 54 patients and compared with 152 standard TEP operations. The mean operative time was significantly shorter in the standard TEP series (61.8 ± 26.0 vs. 70.9 ± 23.8 min, p = 0.04). Other perioperative parameters, including the length of hospital stay, time until return to full activity, complication rate, pain score, and cosmetic result, were all comparable between the two techniques. Our short-term experience with LESS TEP inguinal hernia repair has shown that in experienced hands, inguinal hernia repair via the LESS TEP technique is as safe as the standard TEP technique. However, based on our evidence, we currently believe that the LESS TEP technique is not an efficacious surgical alternative to the standard TEP technique for inguinal hernias.

  20. Ability of TEP1 in intestinal flora to modulate natural resistance of Anopheles dirus.

    Science.gov (United States)

    Wang, Yanyan; Wang, Ying; Zhang, Jingru; Xu, Wenyue; Zhang, Jian; Huang, Fu Sheng

    2013-08-01

    Blocking transmission of malaria is a reliable way to control and eliminate infection. However, in-depth knowledge of the interaction between Plasmodium and mosquito is needed. Studies suggest that innate immunity is the main mechanism inhibiting development of malaria parasites in the mosquito. Recent studies have found that use of antibiotics that inhibit the mosquito gut flora can reduce the immune response of Anopheles gambiae, thereby contributing to the development of malaria parasites. In our study, we used the non susceptible model of Anopheles dirus-Plasmodium yoelii to explore the effect of Anopheles intestinal flora on the natural resistance of A. dirus to P. yoelii. We found that in mosquitoes infected with Plasmodium, the intestinal flora can regulate expression of thioester-containing protein (TEP1) via an RNAi gene-silencing approach. Our results suggest that in the absence of TEP1, the natural microbiota cannot suppress the development of P. yoelii in A. dirus. This suggests that AdTEP1 plays an important role in the resistance of A. dirus to P. yoelii. The intestinal flora may modulate the development of P. yoelii in A. dirus by regulating TEP1 expression. Copyright © 2013 Elsevier Inc. All rights reserved.

  1. Characterisation of transparent exopolymer particles (TEP) produced during algal bloom: A membrane treatment perspective

    KAUST Repository

    Villacorte, Loreen O.

    2013-01-01

    Algal blooms are currently a major concern of the membrane industry as it generates massive concentrations of organic matter (e.g. transparent exopolymer particles [TEP]), which can adversely affect the operation of membrane filtration systems. The goal of this study is to understand the production, composition and membrane rejection of these organic materials using different characterisation techniques. Two common species of bloom-forming freshwater and marine algae were cultivated in batch cultures for 30days and the productions of TEP and other organic matter were monitored at different growth phases. TEP production of the marine diatom, Chaetoceros affinis, produced 6-9 times more TEP than the freshwater blue-green algae, Microcystis. The organic substances produced by both algal species were dominated by biopolymeric substances such as polysaccharides (45-64%) and proteins (2-17%) while the remaining fraction comprises of low molecular weight refractory (humic-like) and/ or biogenic organic substances. MF/UF membranes mainly rejected the biopolymers but not the low molecular weight organic materials. MF membranes (0.1-0.4 lm) rejected 42-56% of biopolymers, while UF membranes (10-100 kDa) rejected 65-95% of these materials. Further analysis of rejected organic materials on the surface of the membranes revealed that polysac-charides and proteins are likely responsible for the fouling of MF/UF systems during an algal bloom situation. © 2013 Desalination Publications.

  2. NOM and TEP fouling of a forward osmosis (FO) membrane: Foulant identification and cleaning

    KAUST Repository

    Valladares Linares, Rodrigo

    2012-12-01

    The study of forward osmosis (FO) membranes has increased due to the already demonstrated advantages compared to high-energy membrane processes such as reverse osmosis (RO). This research focuses on characterization of the natural organic matter (NOM) fraction causing fouling on the active layer (AL) of a FO membrane in a novel plate and frame module configuration, facing secondary wastewater effluent as a feed solution (FS) and seawater used as a draw solution (DS). In addition, transparent exopolymer particles (TEP) were observed on the support layer (SL) of the membrane in contact with the DS. The NOM fouling layer, after characterizing the water samples and membranes used, was found to be composed of biopolymers and protein-like substances, which adversely affect the flux of water through the FO membrane. However, NOM fouling showed high reversibility, up to 90% when air scouring for 15. min is used as a cleaning technique. The irreversible fouling in this work was found to be 8.2% after chemical cleaning. On the support layer of the membrane, TEP formed clusters clearly identifiable with an optical microscope and a TEP-specific dye. Chemical cleaning with 1% NaOCl for 10. min proved to be the most effective method to remove TEP. © 2012.

  3. Transparent Exopolymer Particles (TEP) in the NE Aegean Sea frontal area: Seasonal dynamics under the influence of Black Sea water

    Science.gov (United States)

    Parinos, C.; Gogou, A.; Krasakopoulou, E.; Lagaria, A.; Giannakourou, A.; Karageorgis, A. P.; Psarra, S.

    2017-10-01

    The abundance of Transparent Exopolymer Particles (TEP) was determined on a seasonal basis (autumn, spring and summer) along a north-south transect in the NE Aegean Sea and the vicinity of the Dardanelles Straits. Their distribution patterns were studied in respect to hydrographic conditions and water mass characteristics in the area, as well as particulate organic carbon (POC) concentrations, changes in standing stocks of chlorophyll-α and bacterial production. TEP concentrations ranged from 15.4 to 188 μg GX eq L-1. Their spatial distribution patterns within the euphotic zone displayed significant seasonal variability, which appears to closely reflect the temporal variation of the water column structure, resulting from the encounter and interplay of the Black Sea and Levantine Water masses, and the associated biogeochemical processes. Minimum TEP concentrations during autumn could be likely attributed to a minor quantity of TEP and/or its dissolved precursors exuded by phytoplankton and their enhanced degradation due to their long residence time in the water column. During spring, high TEP production was mediated by actively growing phytoplankton, while during summer a positive link to the intense stratification of the water column and the enhanced bacterial growth within the Black Sea Water layer was observed. The results reported in this study highlight the fact that TEP carbon represents a significant fraction of the POC pool. Moreover, TEP production is critical in promoting particle coagulation rates, playing an important role in carbon cycling/transportation out of the euphotic zone.

  4. Co-existence of electricity, TEP, and TGC markets in the Baltic Sea Region

    International Nuclear Information System (INIS)

    Hindsberger, Magnus; Nybroe, Malene Hein; Ravn, Hans F.; Schmidt, Rune

    2003-01-01

    This paper analyses the application of two policy instruments, tradable emission permits (TEPs) and tradable green certificates (TGCs) to the electricity sector in an international context. The paper contains an explicit modelling at two levels of abstraction, one suitable for defining and analysing basic functionalities and one suitable for numerical analysis in relation to countries in the Baltic Sea Region. Emphasis is on estimating implications in quantitative terms for countries in the Baltic Sea Region in 2010 when the TEP market in the analysis extends to four Nordic countries (Denmark, Finland, Norway, Sweden), and the TGC market extends to North European EU countries (Denmark, Finland, Sweden, Germany). The study concludes that within the range of goals stipulated in the EU draft directive (23.6% renewable energy) and the Kyoto targets for emissions, the following prices are affected significantly: from -2 to +10 Euro/MWh for electricity spot prices, TGC prices up to 50 Euro/MWh, TEP prices up to 18 Euro/t CO 2 and up to +15 Euro/MWh on the consumer cost. It is shown that such price changes have important consequences for the production and investment patterns in the electricity sector, and the resulting patterns will be clearly different according to the specific numerical targets for the two goals. An immediate consequence is increased pressure on transmission lines. Further, the introduction of TEP and TGC markets will imply a restructuring of the electricity sector, e.g. (depending on the specific combination of targets) by a significant increase in wind power capacities. However, this will have to be counterbalanced by access to production technologies that have fast regulation properties and/or that may maintain voltage stability. However, the price signals of TGCs (and to some extent also TEPs) that will enhance wind power investments will simultaneously hamper investments in technologies that are a precondition for extensive use of wind power

  5. Carbon content and C:N ratio of transparent exopolymeric particles (TEP) produced by bubbling exudates of diatoms

    DEFF Research Database (Denmark)

    Mari, Xavier

    1999-01-01

    The carbon content of transparent exopolymeric particles (TEP) was measured in the laboratory in particles produced by bubbling exudates of the diatom Thalassiosira weissflogii, grown under nitrogen non-limited conditions (N:P = 7). The carbon content of these particles (TEP-C) appears to vary...... for dissolved organic carbon in coastal seas. The carbon to nitrogen ratio of TEP was measured from particles formed by bubbling exudates of the diatoms T. weissflogii, Skeletonema costatum, Chaetoceros neogracile and C. affinis. Each of these diatom species was grown under various N:P ratios, from N......-non-limited to N-limited conditions. While the C:N ratio of the diatom cells grown under N-limited conditions was high (C:N >= 14), the TEP aggregates formed by coagulation of the extracellular release produced by these cells exhibited a C:N ratio relatively constant (C:N = 7.3 ± 2.6) and apparently independent...

  6. Transparent exopolymer particles (TEP) removal efficiency by a combination of coagulation and ultrafiltration to minimize SWRO membrane fouling

    KAUST Repository

    Li, Sheng

    2016-07-02

    This study investigated the impact of coagulation on the transformation between colloidal and particulate transparent exopolymer particles (TEP) in seawater; and the effectiveness of a combined pretreatment consisting of coagulation and UF on minimizing TEP fouling of seawater reverse osmosis (SWRO) membranes. Coagulation with ferric chloride at pH 5 substantially transformed colloidal TEP (0.1–0.4) into particulate TEP (>0.4) leading to a better membrane fouling control. Both 50 and 100 kDa molecular weight cut-off (MWCO) UF membranes removed most of particulate and colloidal TEP without the assistance of coagulation, but coagulation is still necessary for better UF fouling control. The improvement of combined SWRO pretreatment with coagulation and 50 kDa UF membranes was not that much significant compared to UF pretreatment with 50 KDa alone. Therefore, the minimal coagulant dosage for seawater containing TEP should be based on the UF fouling control requirements rather than removal efficiency. © 2016 Elsevier Ltd

  7. Exploiting Earth observation data pools for urban analysis: the TEP URBAN project

    Science.gov (United States)

    Heldens, W.; Esch, T.; Asamer, H.; Boettcher, M.; Brito, F.; Hirner, A.; Marconcini, M.; Mathot, E.; Metz, A.; Permana, H.; Zeidler, J.; Balhar, J.; Soukop, T.; Stankek, F.

    2017-10-01

    Large amounts of Earth observation (EO) data have been collected to date, to increase even more rapidly with the upcoming Sentinel data. All this data contains unprecedented information, yet it is hard to retrieve, especially for nonremote sensing specialists. As we live in an urban era, with more than 50% of the world population living in cities, urban studies can especially benefit from the EO data. Information is needed for sustainable development of cities, for the understanding of urban growth patterns or for studying the threats of natural hazards or climate change. Bridging this gap between the technology-driven EO sector and the information needs of environmental science, planning, and policy is the driver behind the TEP-Urban project. Modern information technology functionalities and services are tested and implemented in the Urban Thematic Exploitation Platform (U-TEP). The platform enables interested users to easily exploit and generate thematic information on the status and development of the environment based on EO data and technologies. The beta version of the web platform contains value added basic earth observation data, global thematic data sets, and tools to derive user specific indicators and metrics. The code is open source and the architecture of the platform allows adding of new data sets and tools. These functionalities and concepts support the four basic use scenarios of the U-TEP platform: explore existing thematic content; task individual on-demand analyses; develop, deploy and offer your own content or application; and, learn more about innovative data sets and methods.

  8. Athletes with inguinal disruption benefit from endoscopic totally extraperitoneal (TEP) repair.

    Science.gov (United States)

    Roos, M M; Bakker, W J; Goedhart, E A; Verleisdonk, E J M M; Clevers, G J; Voorbrood, C E H; Sanders, F B M; Naafs, D B; Burgmans, J P J

    2018-01-30

    Inguinal disruption, a common condition in athletes, is a diagnostic and therapeutic challenge. The aim of this study was to evaluate the effect of endoscopic totally extraperitoneal (TEP) repair in athletes with inguinal disruption, selected through a multidisciplinary, systematic work-up. An observational, prospective cohort study was conducted in 32 athletes with inguinal disruption. Athletes were assessed by a sports medicine physician, radiologist and hernia surgeon and underwent subsequent endoscopic TEP repair with placement of polypropylene mesh. The primary outcome was pain reduction during exercise on the numeric rating scale (NRS) 3 months postoperatively. Secondary outcomes were sports resumption, physical functioning and long-term pain intensity. Patients were assessed preoperatively, 3 months postoperatively and after a median follow-up of 19 months. Follow-up was completed in 30 patients (94%). The median pain score decreased from 8 [interquartile range (IQR) 7-8] preoperatively to 2 (IQR 0-5) 3 months postoperatively (p disruption, selected through a multidisciplinary, systematic work-up, benefit from TEP repair.

  9. Is unilateral laparoscopic TEP inguinal hernia repair a job half done? The case for bilateral repair.

    Science.gov (United States)

    Pawanindra Lal; Philips, Prejesh; Chander, Jagdish; Ramteke, Vinod K

    2010-07-01

    Bilateral laparoscopic totally extraperitoneal (TEP) repair of unilateral hernia is conspicuous in published literature by its absence. There are no studies or data on the feasibility, advantages or disadvantages of bilateral repair in all cases or in any subset of patients with unilateral primary inguinal hernia. The objective of this study is to investigate the feasibility of bilateral laparoscopic exploration for all unilateral cases followed by laparoscopic TEP in all cases and to compare complications, recurrence rates, postoperative pain, patient satisfaction, and return to work retrospectively with a similar number of age-matched retrospective controls. One hundred fifty TEP operations were performed in 75 patients (group A) prospectively and were compared with 75 unilateral TEP operations (group B) in age-matched controls done previously by the same surgeon. All cases were performed under general anesthesia, and TEP repair was performed using three midline ports. All uncomplicated patients were discharged at 24 h, in keeping with departmental policy. Of 75 patients (group A), 25 (33.3%) were clinically diagnosed with bilateral hernia and the rest (50, 66.66%) with unilateral hernia. The distribution of the 25 bilateral cases was 11 bilateral direct and 14 bilateral indirect inguinal hernias. The distribution of the 75 age-matched controls (group B) was all unilateral hernia, of which 47 were right-sided and 28 were left-sided. There were 23 direct hernias and 52 indirect hernias among the control group. The mean operative time for all 150 cases was 76.66 +/- 15.92 min. The operative time in the control group (unilateral hernias) was 66.16 +/- 12.44 min, whereas the operative time in the test group (bilateral repair) was 87.2 +/- 11.32 min. The operative time in the bilateral group was significantly higher, by 21.04 min or 31.88% (p = 0.000). The operative time in the true unilateral group was 82.45 +/- 9.38 min, whereas the operative time in the former

  10. Immune-tolerant elastin-like polypeptides (iTEPs) and their application as CTL vaccine carriers.

    Science.gov (United States)

    Cho, S; Dong, S; Parent, K N; Chen, M

    2016-01-01

    Cytotoxic T lymphocyte (CTL) vaccine carriers are known to enhance the efficacy of vaccines, but a search for more effective carriers is warranted. Elastin-like polypeptides (ELPs) have been examined for many medical applications but not as CTL vaccine carriers. We aimed to create immune tolerant ELPs using a new polypeptide engineering practice and create CTL vaccine carriers using the ELPs. Four sets of novel ELPs, termed immune-tolerant elastin-like polypeptide (iTEP) were generated according to the principles dictating humoral immunogenicity of polypeptides and phase transition property of ELPs. The iTEPs were non-immunogenic in mice. Their phase transition feature was confirmed through a turbidity assay. An iTEP nanoparticle (NP) was assembled from an amphiphilic iTEP copolymer plus a CTL peptide vaccine, SIINFEKL. The NP facilitated the presentation of the vaccine by dendritic cells (DCs) and enhanced vaccine-induced CTL responses. A new ELP design and development practice was established. The non-canonical motif and the immune tolerant nature of the iTEPs broaden our insights about ELPs. ELPs, for the first time, were successfully used as carriers for CTL vaccines. It is feasible to concurrently engineer both immune-tolerant and functional peptide materials. ELPs are a promising type of CTL vaccine carriers.

  11. OR TEP-II: a FORTRAN Thermal-Ellipsoid Plot Program for crystal structure illustrations

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, C.K.

    1976-03-01

    A computer program is described for drawing crystal structure illustrations using a mechanical plotter. Ball-and-stick type illustrations of a quality suitable for publication are produced with either spheres or thermal-motion probability ellipsoids on the atomic sites. The program can produce stereoscopic pairs of illustrations which aid in the visualization of complex packing arrangements of atoms and thermal motion patterns. Interatomic distances, bond angles, and principal axes of thermal motion are also calculated to aid the structural study. The most recent version of the program, OR TEP-II, has a hidden-line-elimination feature to omit those portions of atoms or bonds behind other atoms or bonds.

  12. OR TEP-II: a FORTRAN Thermal-Ellipsoid Plot Program for crystal structure illustrations

    International Nuclear Information System (INIS)

    Johnson, C.K.

    1976-03-01

    A computer program is described for drawing crystal structure illustrations using a mechanical plotter. Ball-and-stick type illustrations of a quality suitable for publication are produced with either spheres or thermal-motion probability ellipsoids on the atomic sites. The program can produce stereoscopic pairs of illustrations which aid in the visualization of complex packing arrangements of atoms and thermal motion patterns. Interatomic distances, bond angles, and principal axes of thermal motion are also calculated to aid the structural study. The most recent version of the program, OR TEP-II, has a hidden-line-elimination feature to omit those portions of atoms or bonds behind other atoms or bonds

  13. Monitoring the aging of pressure vessel steels by TEP measurements: Advantages and current limitations of the method

    International Nuclear Information System (INIS)

    Kleber, X.; Saillet, S.

    2011-01-01

    The TEP (Thermoelectric Power or Seebeck coefficient) characterizes the ability of a material to generate an electrical potential difference when the material is subjected to a heat flux. It can be defined from the Seebeck effect, which manifests itself in a circuit formed by two different metals subjected to a temperature gradient. The origin of the thermoelectric power is, as the resistivity, due to electronic phenomena occurring at the atomic scale in relation to the crystallographic structure of the material. TEP measurements are used to characterize small microstructural changes at the scale of crystal defects. The high sensitivity of TEP makes it an excellent probe able of detecting small changes in the microstructural state, including precipitation, dissolution of alloying elements, hardening and recovery after deformation. It has been shown recently that the TEP of pressure vessels steels was sensitive to irradiation, making this measurement technique a potential candidate for monitoring the aging of the pressure vessel steel. However, the first measurements on Charpy specimens of the EDF monitoring program (Pressure Vessel Surveillance Program) showed a strong negative effect of specimen geometry on the accuracy that can be achieved. In this paper we show what the origins of these inaccuracies are. From numerical simulation and finite element model, we describe the roles of the thermal contact resistance as well as the influence of the geometry of the blocks device. A model is proposed to overcome these negative effects. We also show the effect of the presence of heterogeneities in the material on the TEP measurement, and the importance of their localization. Finally, solutions are proposed to improve the device for measuring TEP on PVSP Charpy specimens. (authors)

  14. Carcinome cutané de Merkel: apport de la TEP-TDM au18FDG

    Science.gov (United States)

    Amal, Guensi; Sara, Taleb; Ghofrane, Cherkaoui Salhi; Malika, Ait Idir; Majdouline, Houjami; Souha, Sahraoui; Abdelatif, Benider; Najoua, Touil; Ghita, Benmoussa; Zineb, Baroudi; Nabil, Chikhaoui

    2016-01-01

    Le carcinome à cellules de Merkel (CCM) est une tumeur cutanée neuroendocrinerare d’évolution imprévisible et à grand potentiel métastatique. Ce néoplasme survient habituellement chez le sujet âgé au niveau des zones photo exposées. L'avidité constante du CCM au 18 fluorodésoxyglucose (FDG) justifie l'intérêt de la tomographie par émission de positon (TEP) au cours de cette pathologie. Toutefois, aucun consensus n'est établi à ce jour. Cette étude rapporte le cas d'une patiente de 25 ans suivie pour CCM métastatique, afin d'attirer l'attention sur cette tumeur particulière et d'illustrer l'intérêt de la TEP au 18 FDG dans la prise en charge de cette entité rare. PMID:27303574

  15. LAS TIC-TAC-TEP: un referente para la educación policial

    Directory of Open Access Journals (Sweden)

    Gloria Esperanza Ortiz Russi

    2015-11-01

    Full Text Available La lectura que las autoras esbozan, hace parte de un discurso tejido durante años en trabajo continuo de cerca a la educación policial, desde el centro de Mediaciones Pedagógicas y Tecnológicas –CEMPE-, se puede comentar que dicho discurso es aún inacabado, pero sí propone una postura clave para ser tenida en cuenta en los procesos educativos que demandan la globalidad en una socio-cultura cada vez más inmersa en las TIC-TAC-TEP,  esas siglas tienen unas nuevas acepciones muy especiales para la educación y que desde la PONAL son necesarias trabajarlas.

  16. Data acquisition and PV module power production in upgraded TEP/AzRISE solar test yard

    Science.gov (United States)

    Bennett, Whit E.; Fishgold, Asher D.; Lai, Teh; Potter, Barrett G.; Simmons-Potter, Kelly

    2017-08-01

    The Tucson Electric Power (TEP)/University of Arizona AzRISE (Arizona Research Institute for Solar Energy) solar test yard is continuing efforts to improve standardization and data acquisition reliability throughout the facility. Data reliability is ensured through temperature-insensitive data acquisition devices with battery backups in the upgraded test yard. Software improvements allow for real-time analysis of collected data, while uploading to a web server. Sample data illustrates high fidelity monitoring of the burn-in period of a polycrystalline silicon photovoltaic module test string with no data failures over 365 days of data collection. In addition to improved DAQ systems, precision temperature monitoring has been implemented so that PV module backside temperatures are routinely obtained. Weather station data acquired at the test yard provides local ambient temperature, humidity, wind speed, and irradiance measurements that have been utilized to enable characterization of PV module performance over an extended test period

  17. Coastal Thematic Exploitation Platform (C-TEP): An innovative and collaborative platform to facilitate Big Data coastal research

    Science.gov (United States)

    Tuohy, Eimear; Clerc, Sebastien; Politi, Eirini; Mangin, Antoine; Datcu, Mihai; Vignudelli, Stefano; Illuzzi, Diomede; Craciunescu, Vasile; Aspetsberger, Michael

    2017-04-01

    The Coastal Thematic Exploitation Platform (C-TEP) is an on-going European Space Agency (ESA) funded project to develop a web service dedicated to the observation of the coastal environment and to support coastal management and monitoring. For over 20 years ESA satellites have provided a wealth of environmental data. The availability of an ever increasing volume of environmental data from satellite remote sensing provides a unique opportunity for exploratory science and the development of coastal applications. However, the diversity and complexity of EO data available, the need for efficient data access, information extraction, data management and high spec processing tools pose major challenges to achieving its full potential in terms of Big Data exploitation. C-TEP will provide a new means to handle the technical challenges of the observation of coastal areas and contribute to improved understanding and decision-making with respect to coastal resources and environments. C-TEP will unlock coastal knowledge and innovation as a collaborative, virtual work environment providing access to a comprehensive database of coastal Earth Observation (EO) data, in-situ data, model data and the tools and processors necessary to fully exploit these vast and heterogeneous datasets. The cloud processing capabilities provided, allow users to perform heavy processing tasks through a user-friendly Graphical User Interface (GUI). A connection to the PEPS (Plateforme pour l'Exploitation des Produits Sentinel) archive will provide data from Sentinel missions 1, 2 and 3. Automatic comparison tools will be provided to exploit the in-situ datasets in synergy with EO data. In addition, users may develop, test and share their own advanced algorithms for the extraction of coastal information. Algorithm validation will be facilitated by the capabilities to compute statistics over long time-series. Finally, C-TEP subscription services will allow users to perform automatic monitoring of some key

  18. Materials development for solar thermoelectric generators, SOLAR-TEP - 2007 Annual report

    Energy Technology Data Exchange (ETDEWEB)

    Bocher, L.; Weidenkaff, A.

    2007-07-01

    This annual report for the Swiss Federal Office of Energy (SFOE) takes a look at the work done at the Swiss Federal Laboratories for Materials Science and Technology EMPA in 2007 on Thermoelectric applications that are emerging as a potential technology that allows the conversion of heat into electric power. This energy conversion procedure uses the Seebeck effect to generate electricity without using moving parts or any chemical conversion. The Solar-TEP project is based on the idea of the potential use of concentrated solar heat as a source of energy for Solar Thermoelectric Generators (Solar-TEG). The development of novel functional materials with enhanced figures of merit, high temperature stability, and without harmful effects is commented on. The authors state that oxide ceramics can be used at high temperatures due to their chemical stability and their resistance to thermal oxidation in air. The advantages offered by thermoelectric modules based on oxide materials for the generation of power with increased temperature operating ranges are discussed. Additionally, thermoelectric oxide devices which can be realised on the basis of low-cost materials with low toxicity are discussed.

  19. The tep1 gene of Sinorhizobium meliloti coding for a putative transmembrane efflux protein and N-acetyl glucosamine affect nod gene expression and nodulation of alfalfa plants

    Directory of Open Access Journals (Sweden)

    Soto María

    2009-01-01

    Full Text Available Abstract Background Soil bacteria collectively known as Rhizobium, characterized by their ability to establish beneficial symbiosis with legumes, share several common characteristics with pathogenic bacteria when infecting the host plant. Recently, it was demonstrated that a fadD mutant of Sinorhizobium meliloti is altered in the control of swarming, a type of co-ordinated movement previously associated with pathogenicity, and is also impaired in nodulation efficiency on alfalfa roots. In the phytopathogen Xanthomonas campestris, a fadD homolog (rpfB forms part of a cluster of genes involved in the regulation of pathogenicity factors. In this work, we have investigated the role in swarming and symbiosis of SMc02161, a S. meliloti fadD-linked gene. Results The SMc02161 locus in S. meliloti shows similarities with members of the Major Facilitator Superfamily (MFS of transporters. A S. meliloti null-mutant shows increased sensitivity to chloramphenicol. This indication led us to rename the locus tep1 for transmembrane efflux protein. The lack of tep1 does not affect the appearance of swarming motility. Interestingly, nodule formation efficiency on alfalfa plants is improved in the tep1 mutant during the first days of the interaction though nod gene expression is lower than in the wild type strain. Curiously, a nodC mutation or the addition of N-acetyl glucosamine to the wild type strain lead to similar reductions in nod gene expression as in the tep1 mutant. Moreover, aminosugar precursors of Nod factors inhibit nodulation. Conclusion tep1 putatively encodes a transmembrane protein which can confer chloramphenicol resistance in S. meliloti by expelling the antibiotic outside the bacteria. The improved nodulation of alfalfa but reduced nod gene expression observed in the tep1 mutant suggests that Tep1 transports compounds which influence nodulation. In contrast to Bradyrhizobium japonicum, we show that in S. meliloti there is no feedback regulation

  20. Earth Observation-Supported Service Platform for the Development and Provision of Thematic Information on the Built Environment - the Tep-Urban Project

    Science.gov (United States)

    Esch, T.; Asamer, H.; Boettcher, M.; Brito, F.; Hirner, A.; Marconcini, M.; Mathot, E.; Metz, A.; Permana, H.; Soukop, T.; Stanek, F.; Kuchar, S.; Zeidler, J.; Balhar, J.

    2016-06-01

    The Sentinel fleet will provide a so-far unique coverage with Earth observation data and therewith new opportunities for the implementation of methodologies to generate innovative geo-information products and services. It is here where the TEP Urban project is supposed to initiate a step change by providing an open and participatory platform based on modern ICT technologies and services that enables any interested user to easily exploit Earth observation data pools, in particular those of the Sentinel missions, and derive thematic information on the status and development of the built environment from these data. Key component of TEP Urban project is the implementation of a web-based platform employing distributed high-level computing infrastructures and providing key functionalities for i) high-performance access to satellite imagery and derived thematic data, ii) modular and generic state-of-the art pre-processing, analysis, and visualization techniques, iii) customized development and dissemination of algorithms, products and services, and iv) networking and communication. This contribution introduces the main facts about the TEP Urban project, including a description of the general objectives, the platform systems design and functionalities, and the preliminary portfolio products and services available at the TEP Urban platform.

  1. Computation code TEP 1 for automated evaluation of technical and economic parameters of operation of WWER-440 nuclear power plant units

    International Nuclear Information System (INIS)

    Zadrazil, J.; Cvan, M.; Strimelsky, V.

    1987-01-01

    The TEP 1 program is used for automated evaluation of the technical and economic parameters of nuclear power plant units with WWER-440 reactors. This is an application program developed by the Research Institute for Nuclear Power Plants in Jaslovske Bohunice for the KOMPLEX-URAN 2M information system, delivered by the USSR to the V-2 nuclear power plants in Jaslovske Bohunice and in Dukovany. The TEP 1 program is written in FORTRAN IV and its operation has two parts. First the evaluation of technical and economic parameters of operation for a calculation interval of 10 mins and second, the control of the calculation procedure, follow-up on input data, determination of technical and economic parameters for a lengthy time interval, and data printout and storage. The TEP 1 program was tested at the first unit of the V-2 power plant and no serious faults appeared in the process of the evaluation of technical and economic parameters. A modification of the TEP 1 programme for the Dukovany nuclear power plant is now being tested on the first unit of the plant. (Z.M.)

  2. Experimental evidence of formation of transparent exopolymer particles (TEP) and POC export provoked by dust addition under current and high pCO2 conditions.

    Science.gov (United States)

    Louis, Justine; Pedrotti, Maria Luiza; Gazeau, Frédéric; Guieu, Cécile

    2017-01-01

    The evolution of organic carbon export to the deep ocean, under anthropogenic forcing such as ocean warming and acidification, needs to be investigated in order to evaluate potential positive or negative feedbacks on atmospheric CO2 concentrations, and therefore on climate. As such, modifications of aggregation processes driven by transparent exopolymer particles (TEP) formation have the potential to affect carbon export. The objectives of this study were to experimentally assess the dynamics of organic matter, after the simulation of a Saharan dust deposition event, through the measurement over one week of TEP abundance and size, and to evaluate the effects of ocean acidification on TEP formation and carbon export following a dust deposition event. Three experiments were performed in the laboratory using 300 L tanks filled with filtered seawater collected in the Mediterranean Sea, during two 'no bloom' periods (spring at the start of the stratification period and autumn at the end of this stratification period) and during the winter bloom period. For each experiment, one of the two tanks was acidified to reach pH conditions slightly below values projected for 2100 (~ 7.6-7.8). In both tanks, a dust deposition event of 10 g m-2 was simulated at the surface. Our results suggest that Saharan dust deposition triggered the abiotic formation of TEP, leading to the formation of organic-mineral aggregates. The amount of particulate organic carbon (POC) exported was proportional to the flux of lithogenic particles to the sediment traps. Depending on the season, the POC flux following artificial dust deposition ranged between 38 and 90 mg m-2 over six experimental days. Such variability is likely linked to the seasonal differences in the quality and quantity of TEP-precursors initially present in seawater. Finally, these export fluxes were not significantly different at the completion of the three experiments between the two pH conditions.

  3. Quantitative real-time PCR analysis of Anopheles dirus TEP1 and NOS during Plasmodium berghei infection, using three reference genes

    Directory of Open Access Journals (Sweden)

    Jonathan W.K. Liew

    2017-07-01

    Full Text Available Quantitative reverse transcription PCR (qRT-PCR has been an integral part of characterizing the immunity of Anopheles mosquitoes towards Plasmodium invasion. Two anti-Plasmodium factors of Anopheles, thioester-containing protein 1 (TEP1 and nitric oxide synthase (NOS, play a role in the refractoriness of Anopheles towards Plasmodium infection and are generally expressed during infection. However, these are less studied in Anopheles dirus, a dominant malaria vector in Southeast Asia. Furthermore, most studies used a single reference gene for normalization during gene expression analysis without proper validation. This may lead to erroneous quantification of expression levels. Therefore, the present study characterized and investigated the expression profiles of TEP1 and NOS of Anopheles dirus during P. berghei infection. Prior to that, the elongation factor 1-alpha (EF1, actin 1 (Act and ribosomal protein S7 (S7 genes were validated for their suitability as a set of reference genes. TEP1 and NOS expressions in An. dirus were found to be significantly induced after P. berghei infection.

  4. The effect of ultrapro or prolene mesh on postoperative pain and well-being following endoscopic Totally Extraperitoneal (TEP hernia repair (TULP: study protocol for a randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Schouten Nelleke

    2012-06-01

    Full Text Available Abstract Background The purpose of this study was to describe the rationale and design of a randomized controlled trial analyzing the effects of mesh type (Ultrapro versus Prolene mesh on postoperative pain and well-being following an endoscopic Totally Extraperitoneal (TEP repair for inguinal hernias (short: TULP trial. Methods and design The TULP trial is a prospective, two arm, double blind, randomized controlled trial to assess chronic postoperative pain and quality of life following implantation of a lightweight (Ultrapro and heavyweight (Prolene mesh in endoscopic TEP hernia repair. The setting is a high-volume single center hospital, specializing in TEP hernia repair. All patients are operated on by one of four surgeons. Adult male patients (≥18 years of age with primary, reducible, unilateral inguinal hernias and no contraindications for TEP repair are eligible for inclusion in the study. The primary outcome is substantial chronic postoperative pain, defined as moderate to severe pain persisting ≥ 3 months postoperatively (Numerical Rating Scale, NRS 4–10. Secondary endpoints are the individual development of pain until three years after the TEP procedure, the quality of life (QoL, recurrence rate, patient satisfaction and complications. Discussion Large prospective randomized controlled studies with a long follow-up evaluating the incidence of chronic postoperative pain following implantation of lightweight and heavyweight mesh in endoscopic (TEP hernia repair are limited. By studying the presence of pain and quality of life, but also complications and recurrences in a large patient population, a complete efficiency and feasibility assessment of both mesh types in TEP hernia repair will be performed. Trial registration The TULP study is registered in the Dutch Trial Register (NTR2131

  5. Community-Based Global Health Program for Maltreated Children and Adolescents in Brazil: The Equilibrium Program (TEP

    Directory of Open Access Journals (Sweden)

    Andrea Horvath Marques

    2015-07-01

    Full Text Available The maltreatment of children and adolescents is a global public health problem that affects high and low-middle income countries (LMICs. In the United States, around 1.2 million children suffer from abuse, while in LMICs such as Brazil these rates are much higher (an estimated 28 million children. Exposition to early environmental stress has been associated with suboptimal physical and brain development, persistent cognitive impairment and behavioral problems. Studies have reported that children exposed to maltreatment are at high risk of behavioral problems, learning disabilities, communication and psychiatric disorders and general clinical conditions such as obesity and systemic inflammation later in life. The aim of this paper is to describe The Equilibrium Program (TEP, a community-based global health program implemented in São Paulo, Brazil to serve traumatized and neglected children and adolescents. We will describe and discuss TEP’s implementation, highlighting its innovation aspects, research projects developed within the program as well as its population profile. Finally, we will discuss TEP’s social impact, challenges and limitations. The program’s goal is to promote the social and family reintegration of maltreated children and adolescents through an interdisciplinary intervention program that provides multi-dimensional bio-psycho-social treatment integrated with the diverse services needed to meet the unique demands of this population. The program’s cost-effectiveness is being evaluated to support the development of more effective treatments and to expand similar programs in other areas of Brazil. Policy makers should encourage early evidence-based interventions for disadvantaged children to promote healthier psychosocial environments and provide them opportunities to become healthy and productive adults. This approach has already shown itself to be a cost-effective strategy to prevent disease and promote health.

  6. Developpement d'outils quantitatifs pour le suivi par imagerie TEP/TDM de la reponse a la chimiotherapie et de sa toxicite

    Science.gov (United States)

    Croteau, Etienne

    L'objectif de ce projet de doctorat est de developper des outils quantitatifs pour le suivi des traitements de chimiotherapie pour le cancer du sein et de leurs effets cardiotoxiques a l'aide de l'imagerie TEP dynamique. L'analyse cinetique en TEP dynamique permet l'evaluation de parametres biologiques in vivo. Cette analyse peut etre utilise pour caracteriser la reponse tumorale a la chimiotherapie et les effets secondaires nefastes qui peuvent en resulter. Le premier article de cette these decrit la mise au point des techniques d'analyse cinetique qui utilisent la fonction d'entree d'un radiotraceur derive de l'image dynamique. Des corrections de contamination radioactive externe (epanchement) et de l'effet de volume partiel ont ete necessaires pour standardiser l'analyse cinetique et la rendre quantitative. Le deuxieme article porte sur l'evaluation d'un nouveau radiotraceur myocardique. Le 11C-acetoacetate, un nouveau radiotraceur base sur un corps cetonique, a ete compare au 11C-acetate, couramment utilise en imagerie cardiaque TEP. L'utilisation de 3H-acetate et 14C-acetoacetate ont permis d'elucider la cinetique de ces traceurs depuis la fonction d'entree et la captation par les mitochondries cardiaques qui reflete la consommation en oxygene, jusqu'a la liberation de leurs principaux metabolites reciproques (3H20 et 14CO2). Le troisieme et dernier article de cette these presente l'integration d'un modele qui evalue la reserve cardiaque de perfusion et de consommation en oxygene. Un modele de cardiomyopathie a ete etabli a l'aide d'un agent chimiotherapeutique contre le cancer du sein, la doxorubicine, reconnu comme etant cardiotoxique. Un protocole de repos/effort a permis d'evaluer la capacite d'augmentation de perfusion et de consommation en oxygene par le coeur. La demonstration d'une reserve cardiaque reduite caracterise la cardiotoxicite. La derniere contribution de cette these porte sur la mise au point de methodes peu invasives pour mesurer la

  7. 探討臺灣學生的自律學習:TEPS 資料的縱貫性分析 Self-Regulation Learning among Taiwanese Students: A Longitudinal Analysis of the TEPS Database

    Directory of Open Access Journals (Sweden)

    趙珮晴 Pei-Ching Chao

    2011-09-01

    Full Text Available 課後學生自主的時間能否自己自律繼續學習,是值得關注的議題。本研究欲瞭解學生從國中到高中自律學習發展情況,以台灣教育長期追蹤資料庫的2,939個追蹤樣本,進行潛在成長曲線模型分析。在本研究的假設模型中發現:兩性學生在自律學習的假設模型無顯著差異,而且國中高自律學習的學生到高中的自律學習成長有限;國中低自律學習的學生到高中自律學習成長幅度較大。至於學生家庭社經地位愈高、父母學校參與和接納的程度愈高,學生國中時期的自律學習情況會愈好;但是學生家庭社經地位愈高、父母學校參與程度愈高,對於學生國中到高中自律學習成長有限,至於父母接納則無顯著影響關係。另外,國中自律學習良好的學生,有較良好的分析能力;但是自律學習無法有效預測分析能力的成長情況。本研究將依據上述研究結果提出相關結論與建議以供參考。 Students self-regulating their learning after school is an important topic. This study examines the development of self-regulation learning (SRL and analytical abilities using 2,939 samples from junior high schools and senior high schools. Data were collected from the Taiwan Education Panel Survey (TEPS. A latent growth curve model was employed to analyze the data. The analysis results are as follows: No gender differences exist regarding the development of SRL and analytical ability in both junior and senior high school students in Taiwan. Junior high school students with higher levels of SRL tend to make less SRL progress during senior high school, whereas students with lower SRL levels tend to make greater progress. Junior high school students with higher family socioeconomic status, greater parental involvement and acceptance, and superior SRL levels demonstrated less SRL progress in senior high school. Additionally, junior high

  8. Dynamics of phytoplankton productivity and exopolysaccharides (EPS and TEP) pools in the Seine Estuary (France, Normandy) over tidal cycles and over two contrasting seasons.

    Science.gov (United States)

    Morelle, Jérôme; Schapira, Mathilde; Claquin, Pascal

    2017-10-01

    Exopolysaccharides (EPS) play an important role in the carbon flux and may be directly linked to phytoplankton and microphytobenthos production, most notably in estuarine systems. However the temporal and spatial dynamics of estuarine EPS are still not well understood, nor how primary productivity triggers this variability at these different scales. The aim of this study was to investigate the primary productivity of phytoplankton and EPS dynamics in the Seine estuary over a tidal cycle in three different haline zones over two contrasted seasons. The other objectives was to investigate the origin of pools of soluble carbohydrates (S-EPS) and transparent exopolymeric particles (TEP) in phytoplankton, microphytobenthos or other compartments. High frequency measurements of productivity were made in winter and summer 2015. Physical and chemical parameters, biomass and EPS were measured at hourly intervals in sub-surface waters and just above the water sediment-interface. Our results confirmed that high frequency measurements improve the accuracy of primary productivity estimations and associated carbon fluxes in estuaries. The photosynthetic parameters were shown to be strongly controlled by salinity and by the concentrations of suspended particle matter at the smallest temporal and at spatial scales. At these scales, our results showed an inverse relationship between EPS concentrations and biomass and productivity, and a positive relationship with sediment resuspension. Additionally, the distribution of EPS appears to be linked to hydrodynamics with the tide at daily scale and with the winter at seasonal scale. At spatial scale, the maximum turbidity zone played an important role in the distribution of TEP. Our results suggest that, in the Seine estuary, between 9% and 33% of the S-EPS pool in the water column can be attributed to phytoplankton excretion, while only 0.4%-1.6% (up to 6.14% in exceptional conditions) originates from the microphytobenthos compartments

  9. Excitation functions of $^{125}$Te(p, xn)-reactions from their respective thresholds up to 100 MeV with special reference to the production of $^{124}I$

    CERN Document Server

    Hohn, A; Scholten, B; Van der Walt, T N; Coenen, H H; Qaim, S M

    2001-01-01

    Excitation functions of the nuclear reactions /sup 125/Te(p, xn) /sup 119,120m,120g,121,122,123,/$ u1/sup 24,125/I were measured for the first time from their respective thresholds up to 100 MeV using the stacked-foil technique. Thin samples were prepared by electrolytic deposition of 98.3% enriched /sup 125/Te on Ti-backing. In addition to experimental studies, excitation functions were calculated by the modified hybrid model code ALICE-IPPE. The experimental and theoretical data generally showed good agreement. From the measured cross section data, integral yields of /sup 123,124,125/I were calculated. The energy range E/sub p/=21 to 15 MeV appears to be very suitable for the production of the medically interesting radionuclide /sup 124/I (T/sub 1/2/=4.18 d; I/sub beta //sup +/=25%). The thick target yield of /sup 124/I amounts to 81 MBq/ mu A h and the level of /sup 125/I-impurity to 0.9%. The /sup 125/Te(p,2n)/sup 124/I reaction gives /sup 124/I yield about four times higher than the commonly used /sup 12...

  10. miR-380-5p-mediated repression of TEP1 and TSPYL5 interferes with telomerase activity and favours the emergence of an “ALT-like” phenotype in diffuse malignant peritoneal mesothelioma cells

    Directory of Open Access Journals (Sweden)

    Graziella Cimino-Reale

    2017-07-01

    Full Text Available Abstract Background Understanding the molecular/cellular underpinnings of diffuse malignant peritoneal mesothelioma (DMPM, a fatal malignancy with limited therapeutic options, is of utmost importance for the fruitful management of the disease. In this context, we previously found that telomerase activity (TA, which accounts for the limitless proliferative potential of cancer cells, is prognostic for disease relapse and cancer-related death in DMPM patients. Consequently, the identification of factors involved in telomerase activation/regulation may pave the way towards the development of novel therapeutic interventions for the disease. Here, the capability of miR-380-5p, a microRNA negligibly expressed in telomerase-positive DMPM clinical specimens, to interfere with telomerase-mediated telomere maintenance and, hence, with cancer cell growth was assessed on preclinical models of DMPM. Methods DMPM cells were transfected with a miR-380-5p synthetic precursor, and the effects of miRNA replacement were evaluated in terms of growing capability, induction of apoptosis and interference with TA. Reiterated weekly transfections were also performed in order to analyse the phenotype arising upon prolonged miR-380-5p reconstitution in DMPM cells. Results The ectopic expression of miR-380-5p elicited a remarkable inhibition of TA and resulted in DMPM cell growth impairment and apoptosis induction. In particular, we demonstrated for the first time that these effects were the result of a molecular circuitry converging on telomerase associated protein 1 (TEP1, where the miRNA was able to target the gene both directly in unconventional targeting modality and indirectly via p53 accumulation consequent to miRNA-mediated downregulation of testis-specific protein, Y-encoded-like 5 gene. Moreover, miR-380-5p did not cause telomere attrition and cell growth arrest in long-term DMPM transfectants, which in turn showed slightly elongated telomeres and molecular

  11. Dynamics of transparent exopolymeric particles (TEP) and particle ...

    Indian Academy of Sciences (India)

    associated carbohydrates –1.5 M NaCl/saline extracted (Sal-PCHO) and 10 mM EDTA-extracted (CPCHO)and; total bacterial abundance (TBA)to particulate organic carbon pool. A distinct inter-annual variability was observed with an increase in ...

  12. Savannah River Site TEP-SET tests uncertainty report

    International Nuclear Information System (INIS)

    Taylor, D.J.N.

    1993-09-01

    This document presents a measurement uncertainty analysis for the instruments used for the Phase I, II and III of the Savannah River One-Fourth Linear Scale, One-Sixth Sector, Tank/Muff/Pump (TMP) Separate Effects Tests (SET) Experiment Series. The Idaho National Engineering Laboratory conducted the tests for the Savannah River Site (SRS). The tests represented a range of hydraulic conditions and geometries that bound anticipated Large Break Loss of Coolant Accidents in the SRS reactors. Important hydraulic phenomena were identified from experiments. In addition, code calculations will be benchmarked from these experiments. The experimental system includes the following measurement groups: coolant density; absolute and differential pressures; turbine flowmeters (liquid phase); thermal flowmeters (gas phase); ultrasonic liquid level meters; temperatures; pump torque; pump speed; moderator tank liquid inventory via a load cells measurement; and relative humidity meters. This document also analyzes data acquisition system including the presampling filters as it relates to these measurements

  13. Dynamics of transparent exopolymeric particles (TEP) and particle ...

    Indian Academy of Sciences (India)

    Microbial exudates and cell envelopes remain attached to the cell-wall either as tight capsules (extracted by. EDTA and referred hereafter as CPCHO) or as .... communication). Earlier studies indicate that the average sea-surface temperature and salinity varies from 25. ◦. C–35. ◦. C and 10–35psu, respectively and.

  14. Geo-thermo-electric power: geo-TEP materials; Geo-Thermopower. Geo-TEP Materials. Jahresbericht 2006

    Energy Technology Data Exchange (ETDEWEB)

    Bocher, L.; Weidenkaff, A.

    2006-11-15

    This illustrated annual report for 2006 for the Swiss Federal Office of Energy (SFOE) summarises activities carried out at the Swiss Federal Laboratories for Materials Testing and Research EMPA in the area of materials for use in thermo-electric power generation. Work carried out using Perovskite-type oxides exhibiting promising thermo-electric properties is described. The morphology and microstructure of polycrystalline particles are discussed as are the associated Seebeck coefficients. Further work to be carried out in 2007 is briefly reviewed.

  15. Tradeable CO2 emission permits. A quantitative analysis of a TEP system between Annex I countries

    International Nuclear Information System (INIS)

    Koutstaal, P.R.; Kram, T.; Van Rooijen, S.N.M.

    1997-11-01

    Tradeable emission permits can be a cost-effective way to achieve emission reductions between countries or firms. In this study, the role of trading CO 2 emission permits between the Annex I countries of the FCCC is analysed. It is assumed that only countries are allowed to trade and that there is a perfect market without transaction costs and strategic behaviour. For several cases, the consequences for abatement costs, before and after trade, the volume of permits traded and emissions per capita are studied. Moreover, the gains from trade are determined. This study was undertaken before the Kyoto conference, therefore as a starting point for the different cases it was assumed that all countries should reduce their emissions with 10%. The cases studied are: a flat rate of 10% for each country; the differentiated EU distribution combined with a 10% reduction for the other OECD countries; and the so-called Triptych approach applied to all OECD countries. Two trading systems are considered, one covering only the OECD countries and one which also covers Middle and Eastern European countries (in a simplified way). Furthermore, two extreme cases are studied for the OECD trading scheme: equal costs (after trade) per unit of GNP and equal emission per capita (before trade). Tradeable emission permits will considerably reduce total costs compared with no trade by about 50%. The EU will considerably reduce total costs compared with no trade by about 50%. The EU will be a net exporter of permits in an OECD trading scheme (without Middle and Eastern Europe), mainly because the low costs possibilities for reduction of CO 2 emissions in Germany and the United Kingdom. 13 refs

  16. Usefulness of positron emission tomography (TEP) in the assessment of osteo-articular prosthesis

    International Nuclear Information System (INIS)

    Maldonado, A.; Suarez, J.P.; Dominguez, M.L.

    2004-01-01

    Joint arthroplasty is performed with increasing frequency as the population ages. Loosening or infection of the prosthesis is a relatively common event that can limit the lifetime of a prosthesis. Accuracy differentiation between aseptic and septic loosening of the prosthesis remains a challenge because of the consequences for patient management. Moreover, an early diagnosis of infected hip prosthesis is very important for optimal and cost-effective management. Various approaches have developed to visualize infection and inflammation by nuclear medicine techniques. Recently positron emission tomography (PET) with fluorine-l8 labelled 2 fluoro-2-deoxyglucose ( 18 F-FDG) has been shown to delineate infectious and inflammatory foci with high sensitivity owing to the increased glucose metabolism in inflammatory cells. In this paper we review the role of FDG-PET in this common differential diagnosis in patients with total knee and hip prostheses. Different patterns of FDG-PET interpretation have been described as wed as methodological aspects. (author)

  17. The Tumor Suppressor Protein TEP1/PTEN/MMAC1 and Human Breast Cancer

    National Research Council Canada - National Science Library

    Sun, Hong

    2002-01-01

    PTEN is an important tumor suppressor. Both inherited mutations and somatic mutations in the PTEN gene have been frequently found in a variety of human cancers, including the breast cancer, PTEN protein has been shown to possess...

  18. Carcinome cutané de Merkel: apport de la TEP-TDM au18FDG ...

    African Journals Online (AJOL)

    Le carcinome à cellules de Merkel (CCM) est une tumeur cutanée neuroendocrinerare d'évolution imprévisible et à grand potentiel métastatique. Ce néoplasme survient habituellement chez le sujet âgé au niveau des zones photo exposées. L'avidité constante du CCM au 18 fluorodésoxyglucose (FDG) justifie l'intérêt de ...

  19. Sharpening the Theater Engagement Plan (TEP) Focus: The Impact of Higher Order Beliefs and Values

    National Research Council Canada - National Science Library

    Smith, S

    2002-01-01

    .... The very existence of the debate suggests, however, that differences abound, the most fundamental of which are the world views, values, and beliefs that have been molded across the generations...

  20. Usefulness of positron emission tomography (TEP) in the assessment of osteo-articular prosthesis; Utilite de la tomographie par emission de positons (TEP) dans l'etude des protheses osteo-articulaires

    Energy Technology Data Exchange (ETDEWEB)

    Maldonado, A.; Suarez, J.P.; Dominguez, M.L. [Centro PET Complutense, Madrid (Spain)

    2004-12-15

    Joint arthroplasty is performed with increasing frequency as the population ages. Loosening or infection of the prosthesis is a relatively common event that can limit the lifetime of a prosthesis. Accuracy differentiation between aseptic and septic loosening of the prosthesis remains a challenge because of the consequences for patient management. Moreover, an early diagnosis of infected hip prosthesis is very important for optimal and cost-effective management. Various approaches have developed to visualize infection and inflammation by nuclear medicine techniques. Recently positron emission tomography (PET) with fluorine-l8 labelled 2 fluoro-2-deoxyglucose ({sup 18}F-FDG) has been shown to delineate infectious and inflammatory foci with high sensitivity owing to the increased glucose metabolism in inflammatory cells. In this paper we review the role of FDG-PET in this common differential diagnosis in patients with total knee and hip prostheses. Different patterns of FDG-PET interpretation have been described as wed as methodological aspects. (author)

  1. Connectivity , Corridors and S tepping S tones: Conservation Implications of Roe Deer Distribution on the Eastern S teppe

    Directory of Open Access Journals (Sweden)

    Kirk Olson

    2004-06-01

    Full Text Available Information was collected on roe deer ( Capreolus pygargus distribution on the Eastern S teppe of Mongolia from 2000 to 2003. During this period, 65 roe deer were observed. Roe Deer were distributed throughout the Eastern S teppe region, but all sightings occurred in or adjacent to small woodland patches or riparian woodland. These woodland patches and riparian woodlands are likely to be critical roe deer habitat on the otherwise open grasslands of eastern Mongolia. From a management perspective, roe deer can function as an ecological focal species for preservation of these habitats, and conservation of roe deer and their woodlands can conserve a suite of other species also dependent upon this habitat and thus help conserve the biodiversity of Mongolia’ s Eastern S teppe.

  2. Dynamics of transparent exopolymeric particles (TEP) and particle-associated carbohydrates in the Dona Paula bay, west coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Bhaskar, P.V.; Bhosle, N.B.

    tide at regular intervals during 1998-2000 using a 5l Niskin water sampler. The samples were processed for the analyses of temperature, salinity, nutrients, dissolved oxygen, various suspended particulate parameters and bacterial abundance. 2... and adsorption of stain on to filters was negligible. Both the sample and blank filters stained with Alcian blue were soaked in 6 ml of 80% sulfuric acid for 2h. The filters were shaken intermittently during this period. The samples were then centrifuged...

  3. Marine aggregates and transparent exopolymeric particles (TEPs) as substrates for the stramenopilan fungi, the thraustochytrids: Roller table experimental approach.

    Digital Repository Service at National Institute of Oceanography (India)

    Damare, V.S.; Raghukumar, S.

    (bottles C and D). Among the two, their numbers were greater when an initial dose of antibiotics was added (treatments B). The highest number of thraustochytrids was found in treatment B, containing 20 μm filtered water to which antibiotics had been... dose of antibiotics (treatment C). Thraustochytrids showed one or more peaks during the entire experiment. Bacterial numbers were generally high in all treatments. However, their numbers were significantly higher in microplankton-containing water...

  4. Cerebral blood flow and metabolism analysis in parkinsonian disorders; Pathologie extrapyramidale. Apport de l'imagerie de perfusion et du metabolisme (TEP, TEM)

    Energy Technology Data Exchange (ETDEWEB)

    Defebvre, L. [Hopital Roger Salengro, Service de Neurologie, 59 - Lille (France)

    1999-12-01

    Main metabolic and hemodynamic abnormalities detected by single photon emission computerized tomography and positron emission tomography in extra-pyramidal disorders are reported. In the first stage of Parkinson's disease, cortical metabolism and perfusion can be in normal range or moderately and uniformly reduced. A significant decrease may appear with the disease evolution. Marked abnormalities are observed in parkinsonian patients with dementia (subcortical dementia), involving especially the frontal cortex. A marked diffuse cortical hypo-metabolism (temporal, parietal, occipital and frontal cortex) may suggest the diagnosis of dementia with Lewy bodies, especially in case of fluctuating cognitive decline with recurrent visual hallucinations. In progressive supra-nuclear palsy, a frontal cortex hypo-metabolism is reported precociously, preceding sometimes the cognitive impairment. Metabolic pattern find in multiple system atrophy reflects dysfunction of both nigrostriatal pathways and striatum, with a decrease glucose uptake in putamen and caudate nucleus which also involves cerebellum for the patients with cerebellar syndrome. In cortico-basal degeneration, asymmetric fronto-parietal and striatal hypo-metabolism observed in the controlateral hemisphere to the clinically most affected side, constitute the main characteristic well correlated with apraxia. (author)

  5. A standardized resident training program in endoscopic surgery in general and in laparoscopic totally extraperitoneal (TEP) inguinal hernia repair in particular

    DEFF Research Database (Denmark)

    Miserez, Marc; Arregui, Maurice; Bisgaard, Thue

    2009-01-01

    . A standardized preclinical resident training program in endoscopic surgery is described. Also, a standardized clinical training program is proposed with systematic dissection in 10 different consecutive steps for totally extraperitoneal inguinal hernia repair. Continuous mentoring by an expert is an absolute...

  6. Interest of FDG-PET for lung cancer radiotherapy; Interet de la TEP au FDG pour la radiotherapie des cancers bronchiques

    Energy Technology Data Exchange (ETDEWEB)

    Thureau, S.; Mezzani-Saillard, S.; Dubray, B. [Departement de radiotherapie et de physique medicale et QuantIF - Litis, EA 4108, CRLCC Henri-Becquerel, 1, rue d' Amiens, 76038 Rouen (France); Modzelewski, R.; Edet-Sanson, A.; Vera, P. [Departement de medecine nucleaire et QuantIF - Litis, EA 4108, CRLCC Henri-Becquerel, 1, rue d' Amiens, 76038 Rouen (France)

    2011-10-15

    The recent advances in medical imaging have profoundly altered the radiotherapy of non-small cell lung cancers (NSCLC). A meta-analysis has confirmed the superiority of FDG PET-CT over CT for initial staging. FDG PET-CT improves the reproducibility of target volume delineation, especially close to the mediastinum or in the presence of atelectasis. Although not formally validated by a randomized trial, the reduction of the mediastinal target volume, by restricting the irradiation to FDG-avid nodes, is widely accepted. The optimal method of delineation still remains to be defined. The role of FDGPET-CT in monitoring tumor response during radiotherapy is under investigation, potentially opening the way to adapting the treatment modalities to tumor radiation sensitivity. Other tracers, such as F-miso (hypoxia), are also under clinical investigation. To avoid excessive delays, the integration of PET-CT in routine practice requires quick access to the imaging equipment, technical support (fusion and image processing) and multidisciplinary delineation of target volumes. (authors)

  7. F.D.G.-PET scanning in managing patients with lymphoma; La place de la TEP au FDG dans l'evaluation des lymphomes

    Energy Technology Data Exchange (ETDEWEB)

    Bodet-Milin, C.; Kraeber-Bodere, F. [CHU de Nantes, Service de Medecine Nucleaire, Hotel-Dieu, 44 - Nantes (France); Salaun, P.Y. [CHU de Brest, Service de Medecine Nucleaire, 29 - Brest (France); Crespin, C.; Vuillez, J.P. [CHU de Grenoble, Service de Medecine Nucleaire, 38 - Grenoble (France); Kraeber-Bodere, F. [Centre Rene-Gauducheau, Service de Medecine Nucleaire, 44 - Saint-Herblain (France); CRCNA, Inserm UMR 892, 44 - Nantes (France)

    2009-08-15

    The place of positron emission tomography (PET) in the evaluation of diffuse at big cells B lymphomas and hodgkin lymphomas is validated. The clinical impact of the PET registered in end of therapy development is indisputable. recommendations must be followed for images interpretation. The PET is strongly recommended during the first evaluation of the disease because it is a reference examination that makes easy the interpretation at the end of the therapy and allows to evaluate the extension of the disease with a sensitivity and a specificity superior to the computerized tomography. the prognosis value of intermediate evaluations appears certain in the diffuse at big cells B lymphomas and the hodgkin lymphomas but the impact of an early therapy change induced by PET is still to determine. The criteria of interpretation of early evaluations are to standardize. for the other types of lymphomas, the PET can have an interest to confirm the the localized stages, especially for the follicular lymphomas and direct the biopsy for a patient ill of a low range lymphoma suspect of aggressive change. (N.C.)

  8. Does PET change anything in surgical strategy for lung cancer?; Que change la TEP dans la prise en charge chirurgicale des cancers broncho-pulmonaires,

    Energy Technology Data Exchange (ETDEWEB)

    Brouchet, L.; Berjaud, J.; Renaud, C.; Bosinceanu, L.M.; Dahan, M. [Hopital Larrey, Service de Chirurgie Thoracique, 31 - Toulouse (France)

    2004-11-15

    PET scan take in these days a front place in drawing the balance sheet of pulmonary cancer. Its use is not methodical but reserved in doubtful situations: assessment of mediastinal extension or establishing the nature of coin lesions. Discussing the mediastinal lymph node extension the video-mediastinoscopy remains the reference but some of the nodal stations are difficult to be managed in this manner. The arrival of PET scanning offers a different perspective visualizing the metabolic status of the mediastinal lymph nodes. Regarding the 'coin lesion', positron emission topography offers an improvement in evaluation of the benign or the malignant nature, but in our opinion remains indispensable to couple the morphologic and functional explorations in the same moment. (author)

  9. Use of lasilix to explore pelvis pathologies in F.D.G. PET; Utilisation du lasilix pour l'exploration des pathologies pelviennes en TEP au FDG

    Energy Technology Data Exchange (ETDEWEB)

    Bruna-Muraille, C.; Papathanassiou, D.; Cuif-Job, A.; Moussa-Bouharati, K.; Guedec-Ghelfi, R.; Liehn, J.C. [Institut Jean-Godinot, 51 - Reims (France)

    2010-07-01

    Purpose: F.D.G. accumulations in ureters and bladder can be annoying to interpret PET examinations in case of pelvis pathology, especially for uterine cervix tumors and for some ganglions localizations. The aim of this study was to confirm that the injection of furosemide before F.D.G. scintigraphy leads to a noticed concentration reduction of the tracer in urine, what can allow a better analysis of pelvis pathology and to evaluate the possibility of using this technique in practice. Conclusions: the Lasilix injection before a PET with F.D.G. in patients suffering of a pelvis pathology allows a noticed reduction of urine intensity, making easier the interpretation for a number of pelvic disorders. however, on 26 studied patients, 3 presented urged incontinence during examination, that poses a limitation of the technique and requires the selection, when a prior medical examination, of patients susceptible to receive this protocol. (N.C.)

  10. Non-oncological positron emission tomography (PET): brain imaging; La tomographie par emission de positons (TEP) hors oncologie: l'exploration du cerveau

    Energy Technology Data Exchange (ETDEWEB)

    Lomena, F. [Centro de Diagnostico por la imagen (CDIC), Hospital Clinic, Servicio de medicina nuclear, Barcelona (Spain)

    2008-10-15

    Positron emission tomography (PET) allows evaluation of the central nervous system function. Imaging of regional cerebral blood flow and metabolism, and of several neurotransmission systems may be obtained using PET. PET quantification is accurate and has good test-retest reliability. For research purposes, PET has been used to study brain physiology, to explore neurological and psychiatric diseases pathophysiology and for the new drugs research and development. F.D.G. is the only PET radioligand with clinical application. Following criteria of evidence-based medicine, the clinical indications of F.D.G.-PET are: evaluation of treated gliomas, pre surgical study of partial refractory epilepsy and diagnosis of Alzheimer's disease when it is impossible to differentiate clinically from fronto-temporal dementia.

  11. Assessment of suspected infection of hip or knee endoprosthesis by nuclear medicine techniques; Nuklearmedizinische Abklaerung bei vermuteter Infektion einer Hueft- oder Knie-TEP

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, M.; Dietlein, M.; Schicha, H. [Koeln Univ. (Germany). Klinik und Poliklinik fuer Nuklearmedizin; Delank, K.S. [Koeln Univ. (Germany). Klinik und Poliklinik fuer Orthopaedie

    2007-06-15

    Complications after hip endoprosthesis operation occur with a frequency of 1-2 % after primary operation and with 3-5 % after revision arthroplasty and are even more frequent after knee arthroplasty. The differentiation between aseptic loosening and bacterial infection is very important. In aseptic loosening a one-step revision is usually possible. In case of bacterial infection, all foreign material has to be removed first to allow cure from the infection. After healing and absence of bacteria a follow-up operation is possible with insertion of a new prosthesis. Diagnosis and therapy of a painful hip or knee endoprosthesis are difficult, because patient history, clinical examination, laboratory results including microbiological investigation of puncture material and results of radiological examinations may all be inconclusive. Quite a number of nuclear medicine procedures have been published in the past to help in the differentiation between aseptic loosening and bacterial infection of a painful hip or knee endoprosthesis. No single method can be regarded as excellent and without disadvantages. In the international literature the combined leucocyte-marrow imaging has been propageted as superior technique. In Germany, combined leucocyte-marrow imaging is not available in the published form. Moreover, this technique is time consuming, cost intensive and requires direct work with blood. Therefore, infection imaging with labelled antibodies or labelled fragments of antibodies may be regarded as the method of choice for most nuclear medicine physicians. With semiquantitative evaluation a comparative diagnostic accuracy may be achieved. {sup 18}F-FDG-PET is not able to differentiate reliably between abacterial polyethylene abrasion and septic inflammation. However, with pattern recognition of the distribution of {sup 18}F-FDG around a hip prosthesis an approach with clinically acceptable results has been published. A normal {sup 18}F-FDG-PET can reliably exclude an infection. Concerning knee prostheses such a differentiation with the help of {sup 18}F-FDG pattern recognition has not been successful so far. Therefore, in knee endoprosthesis labelled antibodies or labelled fragments of antibodies may be regarded as the method of choice for most nuclear medicine physicians. It may be regarded as somehow disappointing that a basically attractive approach with {sup 99m}Tc-ciprofloxacine has not fulfilled the expectations of excellent discrimination between prosthetic loosening and septic inflammation. No single diagnostic procedure in nuclear medicine is able to detect bacterial infection in a direct manner. Therefore, it is important to know the limitations of the diagnostic methods in nuclear medicine. (orig.)

  12. The deep cerebral stimulation of the under thalamic nucleus modifies the cerebral metabolism in {sup 18}FDG-Tep of obsessive compulsive patients; La stimulation cerebrale profonde du noyau sous thalamique modifie le metabolisme cerebral en 18FDG-TEP des patients obsessionnels compulsifs

    Energy Technology Data Exchange (ETDEWEB)

    Le Jeune, F.; Garin, E. [Service de medecine nucleaire, centre Eugene-Marquis, Rennes, (France); Verin, M.; Peron, J. [service de neurologie, CHU Pontchaillou, Rennes, (France); Mallet, L.; Yelnik, J. [Inserm, Avenir Team, Behavior, Emotion and Basal Ganglia, IFR 70, Pitie-Salpetriere, Paris, (France); Kreps, M.O. [Inserm U796, service de psychiatrie, hopital Sainte-Anne, Paris, (France); Drapier, D.; Millet, B. [service de psychiatrie adulte, centre hospitalier Guillaume-Regnier, Rennes, (France)

    2009-05-15

    The aim of this work was to find again this orbito-frontal hyper metabolism among the resistant obsessive compulsive disorder patients that are going to benefit of a deep cerebral stimulation of the under thalamus nucleus and to demonstrate that this new therapy approach leads a reduction of the metabolism in this area in correlation with the clinical improvement. It is about the first study realized in isotopic functional imaging on ten resistant compulsive disorder patients treated by bilateral deep cerebral stimulation of the under thalamus nucleus. It shows that the treatment efficiency is in relation with a reduction of the glucide metabolism in the right orbito-frontal cortex. It suggests equally that the under thalamus nucleus would be functionally linked to the orbito-frontal cortex. (N.C.)

  13. Detection of primary tumor by {sup 18}F-FDG-TEP in patients with cup syndrome; Role de la tomographie par emission de positons ({sup 18}F-FDG-TEP) pour la detection des tumeurs primitives lors de la decouverte de metastases

    Energy Technology Data Exchange (ETDEWEB)

    Alberini, J.L.; Belhocine, T.; Daenen, F.; Hustinx, R.; Rigo, P. [Centre Hospitalier Universitaire de Liege, Sart Tilman, Service de Medecine Nucleaire (Belgium)

    2000-09-01

    To study the performance of whole body {sup 18}F-FDG-PET in the detection of the primary tumor in patients with unknown primary carcinoma in comparison with conventional imaging. Patients and methods: Forty-one patients, without previous history of known cancer, (18 women and 23 men; average age 64,1 years) with bone, brain, lymph node, liver, cutaneous, pleural and epidural metastases were included in a retrospective study. Results of PET (UGM Penn PET 240 H) were compared with those of techniques used in the current conventional procedure. There were 26 true positives, 2 false negatives (1 renal carcinoma and 1 myeloma) and one false positive results. Origins were lung [16], gut [6], breast [3] and head and neck [1] but stayed undetermined in 8 patients. Results of PET were superior to conventional diagnostic procedure in 12 patients and led to modify the therapy management in 11 patients. All known metastatic lesions were detected by PET. FDG-PET can be useful to determine the origin of metastasis. It allows detection of the primary tumor (26/33 patients) and allows evaluation of the spread of the disease. These results have to be confirmed and particularly in patients with highly treatable unknown primary carcinoma. (author)

  14. Variable production of transparent exopolymeric particles by haploid and diploid life stages of coccolithophores grown under different CO2 concentrations

    NARCIS (Netherlands)

    Pedrotti, M.L.; Fiorini, S.; Kerros, M.E.; Middelburg, J.J.; Gattuso, J.P.

    2012-01-01

    The production of transparent exopolymeric particles (TEP) by the coccolithophores, Emiliania huxleyi, Calcidiscus leptoporus and Syracosphaera pulchra was investigated in batch cultures. The abundance, size spectra and carbon content of TEP were examined during the exponential growth phase of both

  15. Thermoelectric power rounding above Tc versus paraconductivity in copper oxide superconductors

    International Nuclear Information System (INIS)

    Cabeza, O.; Yadava, Y.P.; Maza, J.; Torron, C.; Vidal, F.

    1991-01-01

    Thermolelectric power, electrical conductivity and magnetic susceptibility measurements near and above Tc are reported. The observed TEP rounding may be explained in terms of a diffusion electronic contribution to TEP alone, with a non-critical thermoelectric coefficient. (orig.)

  16. Abundance and relationship of bacteria with transparent exopolymer particles during the 1996 summer monsoon in the Arabian Sea

    Digital Repository Service at National Institute of Oceanography (India)

    Ramaiah; Sarma, V.V.S.S.; Gauns, M.; DileepKumar; Madhupratap

    Bacterial abundance and production, numbers, sizes and concentrations of transparent exopolymer particles (TEP) and total organic carbon (TOC) were measured during the 1996 summer monsoon to understand the relationship between TEP, the most labile...

  17. 40 CFR 158.660 - Nontarget plant protection data requirements table.

    Science.gov (United States)

    2010-07-01

    ... vigor R R R TEP 1, 2, 3, 7 850.4400850.5400 Aquatic plant growth (algal and aquatic vascular plant... CR CR TEP 1, 4, 5, 7 850.4150 Vegetative vigor CR CR CR TEP 1, 3, 4, 5, 7 850.4400850.5400 Aquatic... methods used to generate data must include the results of a successful confirmatory method trial by an...

  18. Interests of the PET with 18-F.D.G. in infectious pathology: about a case of systemic candidiasis; Interets de la TEP au 18-FDG en pathologie infectieuse: a propos d'un cas de candidose systemique

    Energy Technology Data Exchange (ETDEWEB)

    Avet, J.; Granjon, D.; Prevot, N.; Isnardi, V.; Dubois, F. [Service de medecine nucleaire, CHU de Saint-etienne, (France); Stephan, J.L.; Berger, C. [service de pediatrie, CHU de Saint-etienne, (France)

    2009-05-15

    We report the interest of the PET with {sup 18}F-F.D.G. in the extension evaluation of injuries and in the therapy decision for a patient suffering of a systemic candida. Conclusions: In spite of a lack of recommendations, because of its great sensitivity for the deep infectious centres detection, the PET with {sup 18}F-F.D.G. can bring useful information to the management and follow up of the systemic infections. (N.C.)

  19. Vasculitis assessment with [{sup 18}F]F.D.G. positron emission tomography; Place de la tomographie par emission de positons (TEP) au [{sup 18}F]FDG dans l'exploration des vascularites

    Energy Technology Data Exchange (ETDEWEB)

    Liozon, E. [CHU Dupuytren, Services de Medecine Interne A, 87 - Limoges (France); Monteil, J. [CHU Dupuytren, Services de Medecine Nucleaire, 87 - Limoges (France)

    2008-10-15

    [{sup 18}F]fluorodeoxyglucose ({sup 18}F.D.G.) positron emission tomography (PET) is a noninvasive metabolic imaging modality that is well suited to the assessment of activity and extent of large vessel vasculitis, such as giant cell arteritis and Takayasu arteritis. PET could be more effective than magnetic resonance imaging in detecting the earliest stages of vascular wall inflammation. The visual grading of vascular [{sup 18}F]F.D.G. uptake makes it possible to discriminate arteritis from atherosclerosis, providing therefore high specificity. High sensitivity can be achieved provided scanning is performed during active inflammatory phase, preferably before starting corticosteroid treatment. Large scale prospective studies are needed to determine the exact value of PET imaging in assessing the large vessel vasculitis outcome and response to immunosuppressive treatment.

  20. Host plants of Carambola fruit fly, Bactrocera carambolae Drew & Hancock(Diptera:Tephritidae);and provisional list of suitable host plants of Carambola fruit fly,(Bactrocera(Bactrocera) carambolae Drew & Hancock(Diptera:Tep

    Science.gov (United States)

    Bactrocera carambolae Drew & Hancock (Diptera: Tephritidae), commonly known as the carambola fruit fly, is native to Southeast Asia, but has extended its geographic range to several countries in South America. As with other tephritid fruit fly species, establishment of B.carambolae in areas where it...

  1. Neurolymphomatosis of the sciatic nerve and F.D.G. PET: case report and review; Neurolymphomatose du nerf sciatique en TEP au FDG: a propos d'un cas et revue de la litterature

    Energy Technology Data Exchange (ETDEWEB)

    Bruna-Muraille, C.; Papathanassiou, D.; Cuif-Job, A.; Liehn, J.C. [Institut Jean-Godinot, Service de Medecine Nucleaire, 51 - Reims (France); Job, L. [CHU Robert-Debre, Service de Radiologie, 51 - Reims (France); Kolb, B.; Himberlin, C.; Delmer, A. [CHU Robert-Debre, Service d' Hematologie Clinique, 51 - Reims (France)

    2009-12-15

    We are reporting the case of a woman who has been suffering from sciatica for several months. A neurolymphomatosis of the sciatic nerve was found. In this report, we present the characteristics of this lesion in conventional imaging and in F.D.G. PET. (authors)

  2. Distribuce otěrových částic UHMWPE v periprotetických tkáních u TEP kyčelního kloubu

    Czech Academy of Sciences Publication Activity Database

    Pokorný, D.; Šlouf, Miroslav; Veselý, F.; Fulín, P.; Jahoda, D.; Sosna, A.; Běláček, J.; Landor, I.; Zolotarevova, E.; Popelka, S.

    2010-01-01

    Roč. 77, č. 2 (2010), s. 87-92 ISSN 0001-5415 R&D Projects: GA MŠk 2B06096 Institutional research plan: CEZ:AV0Z40500505 Keywords : total hip replacement * polyethylene wear * aseptic loosening Subject RIV: CD - Macromolecular Chemistry Impact factor: 1.628, year: 2009 http://www.achot.cz/detail.php?stat=346

  3. Exploration of the S.A.P.H.O. syndrome: PET/CT with {sup 18}FNa vs planar osseous scintigraphy; Exploration du syndrome SAPHO: TEP/TDM au {sup 18}FNa vs scintigraphie osseuse planaire

    Energy Technology Data Exchange (ETDEWEB)

    Ben Ali, K.; Poisson, T.; Hayem, G.; Lebtahi, R.; Sarda-Mantel, L.; Burg, S.; Meyer, O.; Le Guludec, D. [Groupe hospitalier Bichat-Claude-Bernard, 75 - Paris (France)

    2010-07-01

    Our purpose was to study the interest of the PET/CT with {sup 18}FNa (F Na-PET/CT) in the assessment of the lesions synovitis acne pustulosis hyperostosis osteitis (S.A.P.H.O.) syndrome compared to bone planar scintigraphy with hydroxy-methylene diphosphonate (H.M.D.P.) labelled with {sup 99m}Tc. The preliminary results suggest an increase of sensitivity of the F Na-PET/CT compared to bone scintigraphy in the S.A.P.H.O. syndrome exploration ( particularly for the rachis injuries, tips and enthesopathies), without loss of specificity. (N.C.)

  4. Interest of the PET with fluorodeoxyglucose labelled with fluorine 18 in an unexplained feverish dorsalgia; Interet de la TEP au fluorodeoxyglucose marque au fluor 18 dans une dorsalgie febrile inexpliquee

    Energy Technology Data Exchange (ETDEWEB)

    Cristofol, H.; Esquerre, J.P.; Payoux, P. [Medecine nucleaire, CHU Purpan, Toulouse, (France); Delavigne, K. [medecine interne, CHU Purpan, Toulouse, (France)

    2009-05-15

    The objective of tis work is to show that the PET with {sup 18}F-F.D.G. allows to do a diagnosis in the fevers of undetermined origin, where other examination turns out to be negative. In the studied case, it was an active Horton disease. The cortico-therapy could be begin as the PET allowed also to rule out the possibility of an infectious centre. This example questions about the place of skeleton scintigraphy and scanner in the management of fevers of undetermined origin compared to the PET. (N.C.)

  5. Seagrass as major source of transparent exopolymer particles in the oligotrophic Mediterranean coast

    KAUST Repository

    Iuculano, Francesca

    2017-01-09

    The role of seagrass, Posidonia oceanica, meadows as a source of transparent exopolymer particles (TEP) to Mediterranean coastal waters was tested by comparing the TEP dynamics in two adjacent coastal waters in the oligotrophic NW Mediterranean Sea, one characterized by oligotrophic open-sea waters and the other accumulating seagrass leaf litter, together with an experimental examination of TEP release by seagrass litter. TEP concentrations ranged from 4.6 µg XG Eq L−1 to 90.6 µg XG Eq L−1, with mean (±SE) values of 38.7 (±2.02) µg XG Eq L−1 in the site devoid of seagrass litter, whereas the coastal beach site accumulating leaf litter had > 10-fold mean TEP concentrations of 487.02 (±72.8) µg XG Eq L−1 . Experimental evaluation confirmed high rates of TEP production by P. oceanica litter, allowing calculations of the associated TEP yield. We demonstrated that P. oceanica is an important source of TEP to the Mediterranean Sea, contributing an estimated 0.10 Tg C as TEP annually. TEP release by P. oceanica seagrass explains the elevated TEP concentration relative to the low chlorophyll a concentration in the Mediterranean Sea.

  6. Synchronization modulation increases transepithelial potentials in MDCK monolayers through Na/K pumps.

    Directory of Open Access Journals (Sweden)

    Vu Tran

    Full Text Available Transepithelial potential (TEP is the voltage across a polarized epithelium. In epithelia that have active transport functions, the force for transmembrane flux of an ion is dictated by the electrochemical gradient in which TEP plays an essential role. In epithelial injury, disruption of the epithelial barrier collapses the TEP at the wound edge, resulting in the establishment of an endogenous wound electric field (∼100 mV/mm that is directed towards the center of the wound. This endogenous electric field is implicated to enhance wound healing by guiding cell migration. We thus seek techniques to enhance the TEP, which may increase the wound electric fields and enhance wound healing. We report a novel technique, termed synchronization modulation (SM using a train of electric pulses to synchronize the Na/K pump activity, and then modulating the pumping cycles to increase the efficiency of the Na/K pumps. Kidney epithelial monolayers (MDCK cells maintain a stable TEP and transepithelial resistance (TER. SM significantly increased TEP over four fold. Either ouabain or digoxin, which block Na/K pump, abolished SM-induced TEP increases. In addition to the pump activity, basolateral distribution of Na/K pumps is essential for an increase in TEP. Our study for the first time developed an electrical approach to significantly increase the TEP. This technique targeting the Na/K pump may be used to modulate TEP, and may have implication in wound healing and in diseases where TEP needs to be modulated.

  7. Analysis of Thioester-Containing Proteins during the Innate Immune Response of Drosophila melanogaster

    Science.gov (United States)

    Bou Aoun, Richard; Hetru, Charles; Troxler, Laurent; Doucet, Daniel; Ferrandon, Dominique; Matt, Nicolas

    2010-01-01

    Thioester-containing proteins (TEPs) are conserved proteins among insects that are thought to be involved in innate immunity. In Drosophila, the Tep family is composed of 6 genes named Tep1–Tep6. In this study, we investigated the phylogeny, expression pattern and roles of these genes in the host defense of Drosophila. Protostomian Tep genes are clustered in 3 distinct branches, 1 of which is specific to mosquitoes. Most D. melanogaster Tep genes are expressed in hemocytes, can be induced in the fat body, and are expressed in specific regions of the hypodermis. This expression pattern is consistent with a role in innate immunity. However, we find that TEP1, TEP2, and TEP4 are not strictly required in the body cavity to fight several bacterial and fungal infections. One possibility is that Drosophila TEPs act redundantly or that their absence can be compensated by other components of the immune response. TEPs may thus provide a subtle selective advantage during evolution. Alternatively, they may be required in host defense against specific as yet unidentified natural pathogens of Drosophila. PMID:21063077

  8. Analysis of Microstructure Using Thermoelectric Diagnostics for Non-Destructive Evaluation of Materials

    Science.gov (United States)

    Park, Y. D.; Kaydanov, V. I.; Mishra, B.; Olson, D. L.

    2005-04-01

    Measurements of Thermoelectric power (TEP) were used to evaluate microstructural analysis in HSLA steel weldments and retained austenite volume fraction for TRIP steel. First, the measurements of TEP for weld microstructure across weldment have shown good correlation with hardness profile. The different TEP values indicated that changes in weld microstructure can be correlated with TEP values measured. Second, it was demonstrated that retained austenite volume fraction were well correlated to TEP measurements for transformation induced plasticity (TRIP) steels. The results suggest that TEP measurements can be correlated to retained austenite volume fraction for TRIP steels, which do not have same chemical composition and thermal heat treatment processes. The retained austenite volume fraction also was measured by X-ray diffraction (XRD) method. With the introduction of these advanced TEP coefficient measurement techniques, the welding and steel industry will be using analytical tools similar to those instruments applied in the semiconductor industry.

  9. Regulatory challenges for autologous tissue engineered products on their way from bench to bedside in Europe.

    Science.gov (United States)

    Ram-Liebig, Gouya; Bednarz, Juergen; Stuerzebecher, Burkard; Fahlenkamp, Dirk; Barbagli, Guido; Romano, Giuseppe; Balsmeyer, Ulf; Spiegeler, Maria-Elsa; Liebig, Soeren; Knispel, Helmut

    2015-03-01

    Since the late eighties of last century the high potential of tissue engineered products (TEP)s has been shown for the treatment of various diseases and many scientific publications appeared in this field. However, only few products reached the market since. Development of TEPs is a promising but owing to its novelty a very challenging task that requires experts in this still developing field as well as ample financial resources. This paper summarises relevant regulatory challenges during quality, preclinical and clinical development of autologous TEPs in Europe. Selected strategies on how to manage major issues are presented, together with some examples from the development of an autologous TEP for urethroplasty. Considering these aspects may help other investigators with potential strategies during the development of novel TEPs. Copyright © 2014 Elsevier B.V. All rights reserved.

  10. Effects of marine snow and muddy terrigenous sediments on the survival of hard coral recruits

    OpenAIRE

    Fabricius, K. E.; Wild, C.; Wolanski, E.; Abele, Doris

    2003-01-01

    Sedimentation is a major cause of mortality in scleractinian coralrecruits. In this study, we compared the effects of muddy coastalsediments, with and without enrichment by "marine snow" on thesurvivorship of recruits of the hard coral Acropora willisae. Transparentexopolymer particles (TEP) were measured as characteristiccomponents of marine snow using a staining method (Passow&Alldredge1995). Four-week old recruits were exposed to (i) muddy coastal sediments, (ii) TEP, (iii) TEP-enriched mu...

  11. Exsanguination protocol improves survival after major hepatic trauma.

    Science.gov (United States)

    Zaydfudim, Victor; Dutton, William D; Feurer, Irene D; Au, Brigham K; Pinson, C Wright; Cotton, Bryan A

    2010-01-01

    Hepatic injury remains an important cause of exsanguination after major trauma. Recent studies have noted a dramatic reduction in mortality amongst severely injured patients when trauma exsanguinations protocols (TEP) are employed. We hypothesised that utilisation of our institution's TEP at the initiation of hospital resuscitation would improve survival in patients with significant hepatic trauma. All patients who (1) sustained intra-abdominal haemorrhage with Grades III-V hepatic injury and (2) underwent immediate operative intervention between February 2004 and January 2008 were included in the study. TEP was instituted in February 2006, and all subsequent patients who met inclusion criteria and were treated with TEP constituted the study group. Patients who met inclusion criteria, were treated before introduction of TEP, and received at least 10 units packed red blood cells in the first 24h constituted pre-TEP comparison group. Univariate and multivariate analyses evaluated the effects of TEP on the study population. Seventy-five patients were included in the study: 39 in the pre-TEP cohort (31% 30-day survival) and 36 in the TEP cohort (53% 30-day survival). There were no differences in demographics, extent of hepatic injury, or operative approach between the patient groups (all p > or = 0.27). Injury Severity Scores were significantly higher in the TEP group (41+/-18 vs. 28+/-15, p<0.01). TEP patients received more plasma and platelets during operative intervention and significantly less crystalloid (all p<0.01). Occurrence of cardiac dysfunction and abdominal compartment syndrome was significantly lower in TEP patients who survived 24-h post-injury (both p < or = 0.04). After adjusting for the significant negative effects of Grade V injury and involvement of major hepatic vasculature (both p < or = 0.02), TEP significantly improved 30-day survival: OR=0.22, 95% CI: 0.06-0.81, p=0.02. TEP allows for an effective use of plasma and platelets during intra

  12. Trombose venosa profunda e suspeita de tromboembolismo pulmonar: avaliação simultânea por meio de angiotomografia pulmonar e venotomografia combinadas

    Directory of Open Access Journals (Sweden)

    Gomes Laura de Moraes

    2006-01-01

    Full Text Available OBJETIVO: Avaliar a ocorrência e a correlação de tromboembolismo pulmonar (TEP e trombose venosa profunda (TVP por meio de um protocolo único de angiotomografia computadorizada. MATERIAIS E MÉTODOS: Estudo prospectivo realizado de julho de 2003 a junho de 2004 no Hospital Copa D'Or, Rio de Janeiro, RJ. Foram analisadas 116 angiotomografias de pacientes com suspeita clínica de TEP. Após o estudo do tórax, com um intervalo de três minutos e sem injeção adicional de contraste, foram obtidos cortes do diafragma até os joelhos, a fim de pesquisar TVP. RESULTADOS: De 116 pacientes, 23 (19,8% cursaram com TEP, 24 com TVP (20,7%, 15 (12,9% apresentaram tanto TEP quanto TVP e 9 (7,8% apresentaram TVP na ausência de TEP. Dos 23 casos positivos de TEP, 15 apresentaram concomitantemente TVP (65,2%, enquanto em 8 (34,8% foi visto apenas TEP. Dos 24 casos positivos de TVP, 15 (62,5% apresentaram TEP associado, enquanto em 9 (37,5% foi encontrada TVP isolada. CONCLUSÃO: Os resultados demonstraram a forte relação entre TEP e TVP, a importância de pesquisar TVP nos casos com suspeita de TEP e a utilidade do uso combinado da angiotomografia de tórax e da venotomografia como alternativa de único exame de investigação de TEP e TVP simultaneamente.

  13. The use of porcine small intestine submucosa implants might be associated with a high recurrence rate following laparoscopic herniorrhaphy

    Directory of Open Access Journals (Sweden)

    Chen-Hsun Ho

    2015-03-01

    Conclusion: Our data suggest that the use of SIS mesh in endoscopic TEP herniorrhaphy might be associated with a high recurrence rate. The second look laparoscopy in these recurrent cases revealed slow and inadequate integration of host tissue. More evidence is still required to further evaluate the efficacy of SIS mesh in endoscopic TEP herniorrhaphy.

  14. Evaluating Teacher Preparation Using Graduates' Observational Ratings

    Science.gov (United States)

    Ronfeldt, Matthew; Campbell, Shanyce L.

    2016-01-01

    Despite growing calls for more accountability of teacher education programs (TEPs), there is little consensus about how to evaluate them. This study investigates the potential for using observational ratings of program completers to evaluate TEPs. Drawing on statewide data on almost 9,500 program completers, representing 44 providers (183…

  15. Coastal bacterioplankton community response to diatom-derived polysaccharide microgels.

    Science.gov (United States)

    Taylor, Joe D; Cunliffe, Michael

    2017-04-01

    Phytoplankton-derived polysaccharide microgels, including transparent exopolymer particles (TEP), are a major component of the marine organic carbon pool. Previous studies have made correlative links between phytoplankton material and bacterioplankton, and performed experiments that assess general responses to phytoplankton, yet there is a lack of direct empirical evidence of specific bacterioplankton responses to natural phytoplankton polysaccharide microgels. In this study, we used diatom produced TEP in controlled incubation experiments to determine the impact of polysaccharide microgels on a coastal bacterioplankton community. Quantification of bacterial 16S rRNA gene transcripts showed that the addition of TEP caused an increase in bacterioplankton activity. Similarly, high-throughput sequencing of RT-PCR amplified bacterial 16S rRNA gene transcripts showed that active bacterioplankton community structure and diversity also changed in response to microgels. Alteromonadales and Rhodobacterales increased in abundance in response to TEP, suggesting that both bacterioplankton taxa utilize diatom-derived microgels. However, through assessing 13 C-labelled TEP uptake via RNA Stable Isotope Probing, we show that only the Alteromonadales (genus Alteromonas) assimilated the TEP carbon. This study adds utilization of diatom-derived TEP to the metabolic repertoire of the archetypal copiotrophic bacterioplankton Alteromonas, and indicates that the Rhodobacterales may utilize TEP for other purposes (e.g. attachment sites). © 2016 Society for Applied Microbiology and John Wiley & Sons Ltd.

  16. Journal of Earth System Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Bacterial abundance and production, numbers, sizes and concentrations of transparent exopolymer particles (TEP) and total organic carbon (TOC) were measured during the 1996 summer monsoon to understand the relationship between TEP, the most labile particulate organic carbon, and bacteria. While high regional ...

  17. Integrating Academic Language into Content Methodology: Supporting Math and Science Teacher Candidates to Meet Students' Language Needs

    Science.gov (United States)

    Freking, Frederick; Park, Jaime; Francois, Annamarie

    2015-01-01

    This article describes how a teacher-education program (TEP), whose mission is to improve schooling for linguistically diverse students, develops its' teacher candidate's critical dispositions and pedagogy related to academic-language (AL) development and how candidate performance on PACT can help TEPs better assess and improve how AL…

  18. Evaluation of immunocompatibility of tissue-engineered periosteum

    Energy Technology Data Exchange (ETDEWEB)

    Zhao Lin; Wang Shuanke; Xia Yayi; Liu Jia; He Jing; Wang Xin [Orthopaedic Institute of the 2nd Hospital of Lanzhou University, 80 CuiYingMen, ChengGuan District, Lanzhou City, 730030 (China); Zhao Junli, E-mail: bonezl@qq.com [Department of Nephrology, the 2nd Hospital of Lanzhou University, 80 CuiYingMen, ChengGuan District, Lanzhou City, 730030 (China)

    2011-02-15

    Tissue-engineered periosteum (TEP) and 'intramembranous ossification' may be an alternative approach to bone tissue engineering. In the previous study we attained successful bone defect reparation with homemade TEP in an allogenic rabbit model. But its allogenic immunocompatibility remained unknown. In this study TEP was constructed by seeding osteogenically induced mesenchymal stem cells of rabbit onto porcine small intestinal submucosa (SIS). A mixed lymphocyte reaction (MLR) was applied to evaluate the in vitro immunogenicity. The ratio of CD4{sup +}/CD8{sup +} T-lymphocytes was tested kinetically to evaluate the systematic reaction of the TEP allograft, and a histological examination was performed to investigate local inflammation and ectopic osteogenesis. MLR indicated that TEP had a higher in vitro immunostimulation than SIS (p < 0.05). The ratios of CD4{sup +}/CD8{sup +} lymphocytes increased in both TEP and SIS implanted groups in 2 weeks, followed by a decrease to a normal level from 2 to 4 weeks. Histological examination revealed modest lymphocyte infiltration for no more than 2 weeks. Moreover, subcutaneous ectopic ossification was observed in TEP allograft animals (8/12). Our findings imply that TEP has a certain immune reaction for the allograft, but it is not severe enough to impact osteogenesis in the allogenic rabbit model.

  19. Paradox-Proof Utility Functions for Heavy-Tailed Payoffs: Two Instructive Two-Envelope Problems

    Directory of Open Access Journals (Sweden)

    Michael R. Powers

    2015-01-01

    Full Text Available We identify restrictions on a decision maker’s utility function that are both necessary and sufficient to preserve dominance reasoning in each of two versions of the Two-Envelope Paradox (TEP. For the classical TEP, the utility function must satisfy a certain recurrence inequality. For the St. Petersburg TEP, the utility function must be bounded above asymptotically by a power function, which can be tightened to a constant. By determining the weakest conditions for dominance reasoning to hold, the article settles an open question in the research literature. Remarkably, neither constant-bounded utility nor finite expected utility is necessary for resolving the classical TEP; instead, finite expected utility is both necessary and sufficient for resolving the St. Petersburg TEP.

  20. Positron Emission Tomography/Computed Tomography is useful in the follow-up of well-differentiated thyroid carcinoma with elevated anti thyroglobulin antibodies; Le MorphoTEP au FDG est un examen utile dans les cancers differencies de la thyroide avec elevation des anticorps antithyroglobuline

    Energy Technology Data Exchange (ETDEWEB)

    Zerdoud, S.; Dierickx, L.; Caselles, O.; Brillouet, S.; Courbon, F. [Institut Claudius-Regaud, Service de Medecine Nucleaire, 31 - Toulouse (France); Benlyazid, A.; Sarini, J.; Courbon, F. [Institut Claudius-Regaud, Dept. de Chirurgie, 31 - Toulouse (France); Dahimene, S.; Courbon, F. [Institut Claudius-Regaud, Dept. de Biologie, 31 - Toulouse (France); Caron, P.; Courbon, F. [Hopital Rangueil, Service d' Endocrinologie, 31 - Toulouse (France); Bastie, D.; Courbon, F. [Hopital Rangueil, Service de Medecine Nucleaire, 31 - Toulouse (France)

    2008-09-15

    Aim: Assessment of the clinical impact of a PET/CT with F.D.G. for the follow-up of differentiated thyroid cancer (D.T.C.) with rising or positive thyroglobulin autoantibodies (AbTg) level and negative or inconclusive conventional imaging work-up. Methodology:This retrospective study involves 15 patients seen in follow-up with confirmed D.T.C. primarily treated with total thyroidectomy and Iodine-131. Patients presenting increased AbTg and a negative or non informative conventional workout were included. The results of the PET/CT were correlated with histology and/or clinical follow-up. The clinical impact was determined on a change of intention to treat, which was decided upon in multidisciplinary meetings, based on the PET/CT result. Results: We observed 10 true positive exams confirmed via histology in seven patients and via clinical follow-up in three on the average 33 months (20-53 months), three real negative exams with negative follow up of on the average 39.5 months (30-47 months), one false positive and one false negative. The intention to treat was modified in 73.3 % (11/15 patients). PET/CT showed sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 91, 75, 90, 75, 86.6% respectively. There was a large and comparable dispersion of the AbTg values in both the true positive and the true negative groups, the kinetic of AbTg evolution could have a predictive value of a positive PET. Discussion/Conclusion: PET/CT with F.D.G. seems to be very useful in the therapeutic management of D.T.C. in the case of AbTg increased or positive, in particular for the patients with N1 in the initial staging. Further studies are suggested to confirm the very promising negative predictive value and specificity of this exam in a larger number of patients. (authors)

  1. Study, development and validation of a dead-timeless electronic architecture concept for highly sensitive PET (Positron Emission Tomograph); Etude, developpement et validation d'un concept d'architecture electronique sans temps mort pour TEP de haute sensibilite

    Energy Technology Data Exchange (ETDEWEB)

    Vert, P.E

    2007-03-15

    Positron emission tomographs (PET) are fitted with highly capable reading electronics, which owns qualities and drawbacks. Highly accused at first as an explanation of the poor sensitivity of these imagers, the present study points out that the dead-times shared along the chains contribute to only 16 % in the data losses at a typical activity of 10 {mu}Ci/ml. The gross acquisition rates could thus be raised by 20 % through a suppression of these saturations. Looking in details at the philosophy of the acquisition procedure, a property appears to circumscribe the sensitivity even more: the timing resolution. The latter conditions, to the first order, the rejection capabilities of random events, part of the scattered ones and hence noise which is finally rated to the true coincidences the signal is made up of. Minimizing the resolving time goes through the suppression of the unneeded actors along with the adoption of a well adapted time-stamping method (optimal filtering). In doing so, the intrinsic channel resolution appears to be possibly lowered by a factor 7, reducing to 350 ps. The bottom value of the coincidence window may be narrowed as a consequence, leading to an increase of the NECR (noise equivalent count rate) by 50 per cent. At this stage, a time of flight (TOF) algorithms can be implemented. As an opportunist, it promises a reduction of the noise variance by 430 %, a gain that echoes on the NECR figure. Finally merging all these ideas allows to expect an improvement close to an order of magnitude on the NECR, with the hope of routine exams shortened by the same amount. In this context, it appeared logical to imagine a new electronics acquisition synoptic dedicated to fully pixelized PET. The number of channels blows up by the way when compared to the existing, this statement being partially balanced by the decision to fully integrate the electronics. The measures of the energy and time are planned to be performed with a single channel, with a continuous and dead-timeless reading of the events. The development of the microelectronics circuits is under way, the three first blocks being described in this dissertation. (author)

  2. Interests of the PET-T.D.M. with F.D.G. in the Hodgkin nodular disease lymphocyte predominance type: about one case; Interets de la TEP-TDM au FDG dans la maladie de Hodgkin nodulaire a predominance lymphocytaire: a propos d'un cas

    Energy Technology Data Exchange (ETDEWEB)

    Puech, J.B.; Guedj, E.; Cammilleri, S.; Mundler, O. [Medecine nucleaire, CHU de La-Timone, Marseille, (France); Curtillet, C.; Michel, G. [hematologie pediatrique, CHU de La-Timone, Marseille, (France)

    2009-05-15

    The objective is to illustrate the interest of the PET-T.D.M. with {sup 18}F.D.G. in the diagnosis of the nodular Hodgkin disease with lymphocyte predominance; or Loppema-Lennert para granuloma. This disease is a rare anatomo-clinical item of Hodgkin disease characterized by a slow evolution, a localised peripheral injury, a trend to local recurrence, and a risk of transformation towards a lymphoma with big cells. This case enlightens the difficulty for the anatomo-pathologist to distinguish follicular lymphoid hyperplasia and nodular Hodgkin with lymphocyte predominance, of different coverage. In spite of the indolent character of this pathology, the PET-T.D.M. with F.D.G. enlightens easily the suspect character of ganglions injuries. This examination takes here a determinant place in the surveillance of these anatomo-clinical entities located at the limit between the benign and the malignant, allowing to guide the behaviour of the hematologist in function of the scintigraphy evolution. (N.C.)

  3. Place of the PET with {sup 18}F.D.G. in the therapy evaluation of the Hodgkin disease after four chemotherapies; Place de la TEP au 18 FDG dans l'evaluation therapeutique de la maladie de Hodgkin apres 4 cures de chimiotherapie

    Energy Technology Data Exchange (ETDEWEB)

    Le Roux, P.Y.; Salauna, P.Y. [CHU de Brest, Service de medecine nucleaire, 29 (France); Milin, C.; Querellou, S.; Kraeber-Bodere, F. [CHU de Nantes, service de medecine nucleaire, 44 (France); Gastine, T.; Le Gouil, S. [CHU de Nantes, service d' hematologie, 44 (France); Rousseau, C. [Centre Rene-Gauducheau, service de medecine nucleaire, 44 - Nantes (France)

    2010-07-01

    Purpose: to evaluate the prognosis value of the PET with F.D.G. in the intermediary therapy evaluation of Hodgkin lymphoma after four chemotherapies, in comparing different criteria of interpretation. Conclusions: our study confirms the excellent negative predictive values of the PET at four chemotherapies in the Hodgkin lymphoma, with different evaluated criteria. The positive predictive value is low with the three methods but PET was decision-making in this series whom 27% of patients were transplanted. The positive predictive value was however higher according to the Gallamini criteria, showing the increased risk of recurrences in this group, even after a graft. (N.C.)

  4. Interest of the PET with {sup 18}F-F.D.G. in the early evaluation of the therapy response to the Hodgkin lymphoma; Interet de la TEP au 18F-FDG dans l'evaluation precoce de la reponse therapeutique du lymphome de Hodgkin

    Energy Technology Data Exchange (ETDEWEB)

    Edera, V.; Boursot, C.; Baulieu, F.; Baulieu, J.L. [Service de medecine nucleaire, CHU de Tours, (France); Senecal, D.; Colombat, P. [service d' hematologie et therapie cellulaire, CHU de Tours, (France)

    2009-05-15

    This retrospective study included 38 consecutive patients having received of an initial and reevaluation PET with {sup 18}F-F.D.G. after two treatments of chemotherapy with a backward step of follow-up of, at least, eighteen months. In conclusion, the evaluation of the early therapy response by the PET with {sup 18}F-F.D.G. to two treatments is complementary of the Goelams prognosis score to evaluate the final prognosis and manage the treatment. Prospective data must confirm these results. (N.C.)

  5. False positive of the PET -CT with {sup 18}F.D.G. in the staging of Hodgkin lymphomas: about two cases;Faux positifs de la TEP-TDM au 18 FDG dans la stadification des lymphomes de hodgkin: a propos de deux cas

    Energy Technology Data Exchange (ETDEWEB)

    Caoduro, C.; Blagosklonov, O.; Angoue, O.; Ungureanu, C.M.; Quemard, G.; Porot, C.; Boulahdour, H. [Hopital Jean-Minjoz, Service de medecine nucleaire, 25 - Besancon (France); Lerais, J.M. [Hopital Jean-Minjoz, Service de radiologie, 25 - Besancon (France)

    2010-05-15

    An isolated hyper fixating bone lesion on a PET / CT performed for staging of lymphoma should suggest a false positive and take advantage of additional tests for etiological aim to allow proper staging of the disease and appropriate therapy. (N.C.)

  6. Diagnosis of spondylodiscitis on osteosynthesis material in PET-T.D.M. with {sup 18}F-F.D.G.. About one case; Diagnostic de spondylodiscite sur materiel d'osteosynthese en TEP-TDM au 18F-FDG. a propos d'un cas

    Energy Technology Data Exchange (ETDEWEB)

    Chastan, M.; Guernou, M.; Edet Sanson, A.; Vera, P.; Hitzel, A. [Centre Henri-Becquerel, Rouen, (France); Etienne, M.; Mirlink, N.; Jurici, S. [CHU Charles-Nicolle, Rouen(France)

    2009-05-15

    The objective was to show the interest of the PET-T.D.M. with {sup 18}F-F.D.G. for the diagnosis of spondylodiscitis on osteosynthesis material. Our observation attests that the PET-T.D.M. is interpretable in spite of the presence of the osteosynthesis material. The use of functional imaging with {sup 18}F-F.D.G. could be considered more quickly, since the spondylodiscitis suspicion on osteosynthesis material in order to get a earlier diagnosis. (N.C.)

  7. Contribution of the PET/CT with F.D.G. to evaluate the tri therapy and the lymphocyte reconstitution in patients infected by HIV; Apport de la TEP/TDM au FDG pour l'evaluation de la tritherapie et de la reconstitution lymphocytaire chez les patients infectes par le VIH

    Energy Technology Data Exchange (ETDEWEB)

    Hamza, F.; Yeddes, I.; El Bez, I.; Evangelista, E.; Meignan, M.; Itti, E. [CHU Henri-Mondor, Service de medecine nucleaire, 94 - Creteil (France); Lelievre, J.D.; Levy, Y. [CHU Henri-Mondor, service immunologie clinique, 94 - Creteil (France); Cheynier, R. [Institut Pasteur, service de virologie, 75 - Paris (France)

    2010-07-01

    Purpose: HIV infection is accompanied by impairment of lymphoid organs that can be detected by PET / CT with F.D.G.. The purpose of this study was to correlate lymphocyte reconstitution with the metabolic activity of lymphoid organs. Conclusions: PET / CT with F.D.G. is an appropriate assessment tool to evaluate the effect of antiviral treatment in lymphoid organs. In addition, she is helping to understand the mechanisms of lymphocyte reconstitution under triple therapy. (N.C.)

  8. Double localization of neuro lymphomatosis in an early relapse of non-Hodgkin lymphoma and ({sup 18}F)-F.D.G. PET-CT: Case report;Double localisation de neurolymphomatose d'une rechute prcoce d'un lymphome non hodgkinien en TEP-TDM au ({sup 18}F)-FDG: a propos d'un cas

    Energy Technology Data Exchange (ETDEWEB)

    Cazaentre, T.; Pascal-ortiz, D. [Hopital Saint-Jean, Service de medecine nucleaire, 66 - Perpignan (France); Sanhes, L.; Vallantin, X. [Hopital Saint-Jean, Service d' hematologie, 66 - Perpignan (France); Cassarini, J.F. [Hopital Saint-Jean, Service de neurologie, 66 - Perpignan (France)

    2010-06-15

    In a patient suffering from left lower limb pain and chin anesthesia, fused PET-CT imaging showed an ({sup 18}F)-F.D.G. uptake along the left sciatic nerve and the mandibular branch of the left trigeminal nerve corresponding to neuro lymphomatosis due to an early relapse of a B-cell non-Hodgkin's lymphoma. (authors)

  9. Performances evaluation of the PET/CT with {sup 18}F-F.D.G. in the diagnosis of peritoneal carcinosis with a colorectal origin; Evaluation des performances de la TEP-TDM au {sup 18}F-FDG dans le diagnostic de la carcinose peritoneale d'origine colorectale

    Energy Technology Data Exchange (ETDEWEB)

    Bullier, E. [CHU de Bordeaux, Service de medecine nucleaire, hopital de Haut-Leveque, 33 (France); Bonichon, F.; Cazeau, A.L. [Institut Bergonie CRLCC d' Aquitaine, service de medecine nucleaire, 33 - Bordeaux (France); Descat, E. [Institut Bergonie CRLCC d' Aquitaine, service de radiologie, 33 - Bordeaux (France); Evrard, S. [Institut Bergonie CRLCC d' Aquitaine, Dept. de Chirurgie, 33 - Bordeaux (France); Picat, Q. [Bergonie CRLCC d' Aquitaine, Dept. de biostatistique, 33 - Bordeaux (France)

    2010-07-01

    Purpose: the purpose of this study is to evaluate the performances and the inter-observers concordances of the PET-CT with {sup 18}F-F.D.G. in the detection of the peritoneal carcinosis in colorectal cancers, with evaluation of peritoneal extension, description of semiotics signs allowing to raise the diagnosis and confrontation of this performance to that of CT. Conclusions: The PET-CT with {sup 18}F-F.D.G. seems to be a powerful and reproducible examination for the peritoneal carcinosis diagnosis, with a methodology of research oriented proofreading of peritoneal carcinosis. Studies are to make to evaluate prospectively the extension of peritoneal carcinosis. (N.C.)

  10. Evaluation of uterine cervix cancer hypoxia by PET with {sup 18}F-F.E.T.N.I.M.. Relation with squamous cell carcinoma (S.C.C.) and osteopontin tumoral markers; Evaluation de l'hypoxie du cancer du col uterin par la TEP au {sup 18}F-FETNIM. Relation avec les marqueurs tumoraux SCC et osteopontine

    Energy Technology Data Exchange (ETDEWEB)

    Barre, E.; Schlageter, M.H.; Groheux, D.; Vercellino, L.; Lussato, D.; Thoury, A.; Hennequin, V.; Hindie, E.; Barranger, E.; Moretti, J.L. [CHU Saint-Louis-Lariboisiere, universite Paris-7, IMDCT, 75 - Paris (France)

    2010-07-01

    Purpose: to evaluate the imaging feasibility of hypoxia of cervical squamous cell carcinoma by PET with {sup 18}F-F.E.T.N.I.M. (Iason). to compare the {sup 18}F-F.E.T.N.I.M. uptake to the metabolic uptake in {sup 18}F-F.D.G. and to study their relationship with the squamous cell carcinoma, tumoral marker and osteoponin, circulating tracer of hypoxia. Conclusions: the F.E.T.N.I.M. uptake by the tumor is always of lower level than the {sup 18}F-F.D.G. uptake. By using the ratio Tumor/Muscle, these preliminary results do not enlighten any correlation between the circulating hypoxia tracer and the tumor uptake of {sup 18}F-F.E.T.N.I.M.. (N.C.)

  11. Feasibility study of the non-invasive estimation of the {beta}{sup +} arterial input function for human PET imaging; Etude de faisabilite de l'estimation non-invasive de la fonction d'entree arterielle {beta}{sup +} pour l'imagerie TEP chez l'homme

    Energy Technology Data Exchange (ETDEWEB)

    Hubert, X.

    2009-12-15

    This work deals with the estimation of the concentration of molecules in arterial blood which are labelled with positron-emitting radioelements. This concentration is called '{beta}{sup +} arterial input function'. This concentration has to be estimated for a large number of pharmacokinetic analyses. Nowadays it is measured through series of arterial sampling, which is an accurate method but requiring a stringent protocol. Complications might occur during arterial blood sampling because this method is invasive (hematomas, nosocomial infections). The objective of this work is to overcome this risk through a non-invasive estimation of {beta}{sup +} input function with an external detector and a collimator. This allows the reconstruction of blood vessels and thus the discrimination of arterial signal from signals in other tissues. Collimators in medical imaging are not adapted to estimate {beta}{sup +} input function because their sensitivity is very low. During this work, they are replaced by coded-aperture collimators, originally developed for astronomy. New methods where coded apertures are used with statistical reconstruction algorithms are presented. Techniques for analytical ray-tracing and for the acceleration of reconstructions are proposed. A new method which decomposes reconstructions on temporal sets and on spatial sets is also developed to efficiently estimate arterial input function from series of temporal acquisitions. This work demonstrates that the trade-off between sensitivity and spatial resolution in PET can be improved thanks to coded aperture collimators and statistical reconstruction algorithm; it also provides new tools to implement such improvements. (author)

  12. Improvement of early response criteria of the PET with F.D.G. in the aggressive lymphoma: importance of the reference area; Amelioration des criteres de reponse precoce de la TEP au FDG dans le lymphome agressif: importance de la zone de reference

    Energy Technology Data Exchange (ETDEWEB)

    Yeddes, I.; Hamza, F.; El Bez, I.; Lin, C.; Evangelista, E.; Meignan, M.; Itti, E. [CHU Henri-Mondor, Service de medecine nucleaire, 94 - Creteil (France); Dupuis, J.; Haioun, C. [CHU Henri-Mondor, Service d' hematologie, 94 - Creteil (France)

    2010-07-01

    Purpose: PET with F.D.G. allows to identify early the patients that respond or not to the first line chemotherapy, from the second therapy. However, the interpretation criteria currently used (Juweid, international harmonization project. JCO 2007) are adapted to evaluation of end of treatment and non to early evaluation, for which the reference zone allowing to judge the positivity of a residual tumor must be evaluated. Conclusions: To interpret the early response to therapy in aggressive lymphoma, it seems justified to refer to a higher reference level ( liver) than this one advocated in international current criteria (mediastinum). (N.C.)

  13. Thyroid medullary carcinoma and PET/CT with {sup 18}F-DOPA in the post surgery follow up: preliminary results; Carcinome medullaire de la thyroide et TEP/TDM a la {sup 18}F-DOPA dans le suivi post-chirurgical: resultats preliminaires

    Energy Technology Data Exchange (ETDEWEB)

    Keomany, J.; Rust, E.; Constantinesco, A.; Imperiale, A. [CHU de Strasbourg, Service de biophysique et medecine nucleaire, 67 (France); Detour, J. [CHU de Strasbourg, Service de radiopharmacie, 67 (France); Chabrier, G.; Goichot, B. [CHU de Strasbourg, Service de medecine interne, endocrinologie et nutrition, 67 (France); Schneegans, O. [FNCLCC Paul-Strauss, 67 - Strasbourg (France)

    2010-07-01

    Purpose: to study the contribution of the PET/CT with {sup 18}F DOPA in the therapy follow-up of patients with a history of medullary thyroid carcinoma and biological suspicion of residual disease or recurrence. Conclusions: The preliminary results show the interest of the PET/CT with {sup 18}F DOPA in the therapy follow-up and the management of patients suffering of medullary thyroid carcinoma in biological relapse. (N.C.)

  14. About one case of mental anorexia associated with a right frontal partial epilepsy diagnosed in crisis by a PET with {sup 18}F.D.G; A propos d'un cas d'anorexie mentale associee a une epilepsie partielle frontale droite diagnostiquee en crise par une TEP au 18-FDG

    Energy Technology Data Exchange (ETDEWEB)

    Avet, J.; Decousus, M.; Dubois, F. [Service de medecine nucleaire, CHU de Saint-etienne, (France); Galusca, B. [service d' endocrinologie, CHU de Saint-etienne, (France); Convers, P. [service de neurologie, CHU de Saint-etienne, (France); Barral, F.G. [service de radiologie, CHU de Saint-etienne, (France)

    2009-05-15

    The physiology of mental anorexia is very controversial. In some cases, it was described an association with injuries close to the right frontal and temporal lobes. We report the case of an anorexia associated to a partial right frontal epilepsy, fortuitously diagnosed in crisis by a PET with {sup 18}F.D.G.. Conclusions: Because of its closely relationship with the limbic system, the abnormalities touching the right frontal area could contribute to the development of dietary behaviour troubles. This case illustrates this relationship and reports in addition a per-critic PET image of partial epilepsy, that is exceptional because of the tracer kinetics. (N.C.)

  15. Interest of delayed images in the detection of small size lesions in positron emission tomography (PET): about a case of peritoneal carcinosis evaluation; Interet des images tardives dans la detection de lesion de petite taille en tomographie par emission de positons (TEP): a propos d'un cas de bilan de carcinose peritoneale

    Energy Technology Data Exchange (ETDEWEB)

    Rakotonirina, H.; Berthelot, C.; Vervueren, L.; Agius, C.; Jeanguillaume, C.; Couturier, O. [Service de medecine nucleaire, CHU d' Angers, (France)

    2009-05-15

    Because of the effect of partial volume, the small injuries (under 1 cm) are not the most often seen in F.D.G.-PET. however, if the gradient tumor/background noise is important, it is sometimes possible to visualize them. To increase this gradient, we can increase the tumor captation of F.D.G. by increasing the time of captation, or reduce the vascular background noise by making easy the urinary excretion. through a clinical case, we remind the interest of delayed images ( 2 hours after injection) associated to the injection of furosemide in the detection of small injuries of peritoneal carcinosis. (N.C.)

  16. Interest of the PET with F DOPA in the exploration of endocrine para neoplastic syndromes (E.P.S.): about four cases; Interet de la TEP a la FDOPA dans l'exploration des syndromes paraneoplasiques endocriniens (SPE): a propos de 4 cas

    Energy Technology Data Exchange (ETDEWEB)

    Moreau Triby, C.; Pina, G.; Bournaud, C. [Centre de medecine nucleaire, groupement hospitalier Est, Lyon, (France); Billotey, C. [CERMEP, Lyon, (France); Raverot, G.; Borson Chazot, F. [service d' endocrinologie, groupement hospitalier Est, Lyon, (France)

    2009-05-15

    In front an ectopic secretion of adrenocorticotropic hormone (ACTH or corticotropin) or growth hormone (GH) the existence of an endocrine tumor must be evoked. The topographical diagnosis of these tumors is often difficult. The positron computed tomography with 6-fluoro-({sup 18}F)-L-dihydroxy-phenylalanine (PET-FDOPA) showed recently a good sensitivity in the detection of well differentiated endocrine tumors. We report our experience of the PET-FDOPA in the explorations of para-neoplasic endocrine syndromes. Our experience was relatively disappointing, this examination being a little contributive for our patients. The scintigraphy of receptors with somatostatin with octreoscan keeps all this place in this indication. (N.C.)

  17. The PET-F.D.G. predicts the high grade recurrent gliomas survival treated by the association of bevacizumab-irinotecan; La TEP-FDG predit la survie des gliomes de haut grade recidivants traites par l'association bevacizumab-irinotecan

    Energy Technology Data Exchange (ETDEWEB)

    Colavolpe, C.; Guedj, E.; Mancini, J.; Bequet-Boucard, C.; Metellus, P.; Barrie, M.; Figarella-Branger, D.; Chinot, O.; Mundler, O. [CHU La Timone, Marseille, (France)

    2009-05-15

    The objective is to evaluate the prognosis value independent of the PET-F.D.G. on the global survival and without progression of recurred high grade gliomas treated by bevacizumab and irinotecan, in comparison with the others prognosis factors of the recurrence. In conclusions, the comparison of the F.D.G. fixation between the tumor area and contralateral one before anti-angiogenic treatment has a prognosis value independent on the global survival and without progression of recurred high grade gliomas treated by bevacizumab/irinotecan. (N.C.)

  18. Comparison of prognosis values of pre therapy PET-T.D.M. with {sup 18}F-F.D.G. and MRI in the uterus cervix cancer; Comparaison des valeurs pronostiques des TEP-TDM au 18F-FDG et IRM pretherapeutiques dans le cancer du col de l'uterus

    Energy Technology Data Exchange (ETDEWEB)

    Chastan, M.; Baron, M.; Diologent, B.; Edet Sanson, A.; Guernou, M.; Vera, P.; Hitzel, A. [Centre Henri-Becquerel, Rouen, (France); Manrique, A. [GIP Cyceron, Caen, (France)

    2009-05-15

    The objective is to compare the prognosis value of the pre-therapy pelvis PET--T.D.M. with {sup 18}F-F.D.G. and MRI in the uterine cervix carcinoma. The conclusions: in the uterine cervix carcinomas, the existence of a pelvis ganglion injury on the pre-therapy PET-T.D.M. with {sup 18}F-F.D.G. is a prognosis factor independent of recurrence and death at one year. The MRI does not bring any additional information relative to the prognosis of the disease. (N.C.)

  19. The deep stimulation of the sub-thalamus nucleus affects the limbic and associative circuits: a study in {sup 18}F-F.D.G. -PET in the Parkinson disease;La stimulation profonde du noyau sous thalamique affecte les circuits limbique et associatif: une etude en 18FDG-TEP dans la maladie de Parkinson

    Energy Technology Data Exchange (ETDEWEB)

    Le Jeune, F.; Garin, E. [Centre Eugene-Marquis, Servive de medecine nucleaire, 35 - Rennes (France); Le Jeune, F.; Peron, J.; Grandjean, D.; Drapier, S.; Haegelen, C.; Garin, E.; Millet, B.; Verin, M. [Universite de Rennes-1, URU comportement et noyaux gris centraux, 35 - Rennes (France); Peron, J.; Drapier, S.; Haegelen, C.; Verin, M. [CHU Pontchaillou, service de neurologie, 35 - Rennes (France); Grandjean, D. [University of Genova, Swiss Center for Affective Sciences, Geneve (Switzerland); Millet, B. [Centre hospitalier Guillaume-Regnier, service de psychiatrie adulte, 35 - Rennes (France)

    2010-05-15

    The purpose of this study is to highlight the changes in brain metabolism in {sup 18}F.D.G.-PET to improve understanding of the non-motor functional role .This study confirms the non-motor functional role of the sub thalamic nucleus (S.T.N.) in limbic and associative circuits in humans.These results provide working hypotheses to study the correlations between neuropsychological alterations clinically diagnosed and cerebral metabolism in order to identify the neural circuits involved. (N.C.)

  20. Quantitative analysis of the PET-F.D.G. in the drug resistant temporal epilepsy: comparison of two methods of spatial normalisation; Analyse quantitative de la TEP-FDG dans l'epilepsie temporale pharmacoresistante: comparaison de deux methodes de normalisation spatiale

    Energy Technology Data Exchange (ETDEWEB)

    Person, C.; Wolf, D.; Louis-Dorr, V. [CRAN-INPL, universite de Nancy, 54 (France); Gillet, N.; Marie, P.Y. [CHU de Nancy, service de medecine nucleaire, 54 (France); Maillard, L. [CHU de Nancy, service de neurologie, 54 (France); Malandin, G.; Ayache, N.; Vespignani, H. [Institut National de Recherche en Informatique et en Automatique (INRIA), 06 - Sophia Antipolis (France); Guedj, E. [Hopital de la Timone, service de medecine nucleaire, AP-HM13 - Marseille (France)

    2010-07-01

    Among the patients who received a PET-F.D.G. for drug resistant temporal epilepsy, the quantification of abnormalities by the B.M. method (B.M.: box matching method) seems to provide a gain in terms of specificity, but perhaps with less sensitivity. Studies are currently underway to optimize the use of this new method. (N.C.)

  1. Quantitative analysis of fluorodeoxyglucose-, fluoro-misonidazole- and fluoro-thymidine-PET images on five patients irradiated for a non-small-cell bronchial cancer; Analyse quantitative d'images de TEP au fluorodesoxyglucose, au fluoromisonidazole et a la fluorothymidine chez cinq patients irradies pour un cancer bronchique non a petites cellules

    Energy Technology Data Exchange (ETDEWEB)

    Thureau, S.; Dubray, B. [Departement de radiotherapie et physique medicale, centre Henri-Becquerel, Rouen (France); Litis EA 4108, QuantiF, universite de Rouen, Rouen (France); Modzelewski, R.; Lelandais, B.; Edet Sanson, A.; Gardin, I.; Vera, P. [Litis EA 4108, QuantiF, universite de Rouen, Rouen (France); Departement de medecine nucleaire, centre Henri-Becquerel, Rouen (France)

    2011-10-15

    As fluorodeoxyglucose-PET (positron emission tomography) is used for the planning of non-small-cell bronchial carcinoma radiotherapy in order to help to define the gross tumour volume (GTV), and as new tracers have been developed to define a biological target volume, the authors report the comparison of several thresholding methods by using fluorodeoxyglucose-, fluoro-misonidazole- and fluoro-thymidine-PET images. They notice important differences between the delineated volumes. Short communication

  2. About a case of pathological muscular hyper fixations in PET-F.D.G.. Diagnosis discussions and reminder of the main differential diagnosis; A propos d'un cas d'hyperfixations musculaires pathologiques en TEP-FDG. Discussion diagnostique et rappel des principaux diagnostics differentiels

    Energy Technology Data Exchange (ETDEWEB)

    Colavolpe, C.; Puech, J.B.; Mundler, O. [CHU Timone, Service de medecine nucleaire, 13 - Marseille (France); Belenotti, P.; Sevy, A.; Ene, N.; Serratrice, J. [CHU Timone, Service de medecine interne, 13 - Marseille (France); Verschueren, A.; Attarian, S. [CHU Timone, Service de neurologie maladies neuromusculaires, 13 - Marseille (France); Azulay, J.P. [CHU Timone, Service de neurologie pathologies du mouvement, 13 - Marseille (France)

    2010-07-01

    The muscle hyper fixing are common in PET-F.D.G.. Their interpretation requires a good knowledge of the main artifactual and pathological causes and the correlation with other clinical and para clinical data. (N.C.)

  3. Interest of the scintigraphy PET {sup 18}F-F.D.G. for the evaluation of the early response to the treatment by adalimumab in the rheumatoid poly-arthritis; Interet de la scintigraphie TEP {sup 18}F-FDG pour l'evaluation de la reponse precoce au traitement par adalimumab dans la polyarthrite rhumatoide

    Energy Technology Data Exchange (ETDEWEB)

    Eder, V.; Courtehoux, M.; Baulieu, J.L. [Service de medecine nucleaire, CHU de Tours, (France); Mulleman, D.; Paintaud, G.; Goupille, P.; Ternant, D. [Service de rhumatologie, CHU de Tours, (France)

    2009-05-15

    The aim of this study was to evaluate the interest of the follow-up of the {sup 18}F-F.D.G. uptake during the treatment of the rheumatoid poly-arthritis by 40 mg during 2 weeks of adalimumab (an anti-TNF-alpha human monoclonal antibody), comparatively to the usual clinical and biological follow-up. The PET with {sup 18}F-F.D.G. is a promising technique to enlighten early the anti inflammatory pharmaco-dynamic effect of the adalimumab in the rheumatoid poly-arthritis. (N.C.)

  4. Unilateral brown fat on [{sup 18}F]-F.D.G. PET/CT in the follow-up of a pleural mesothelioma; Detection unilaterale de graisse brune en [{sup 18}F]-FDG TEP/TDM dans le suivi d'un mesotheliome pleural

    Energy Technology Data Exchange (ETDEWEB)

    Waele, A. de; Deroose, C.M. [Katholieke Universiteit Leuven, Hopitaux Universitaires de Leuven, UZ Leuven, Dept. de Medecine Nucleaire, Leuven (Belgium); Nafteux, P. [Katholieke Universiteit Leuven, Hopitaux Universitaires de Leuven, Dept. de Chirurgie Thoracique, Leuven (Belgium); Nackaerts, K. [Katholieke Universiteit Leuven, Hopitaux Universitaires de Leuven, Dept. de Pneumologie, Leuven (Belgium)

    2009-10-15

    The fixation of the fluorodeoxyglucose (F.D.G.) in the brown fat is generally characterized by a strongly symmetric setting in some areas of predilection.Is reported here the case of a patient that after having undergone a multi modal treatment for a pleural mesothelioma presents a unilateral F.D.G. fixation in the brown fat, this fixation can be inhibited by the administering of a beta adrenergic blocking agent. (N.C.)

  5. Serum activin B concentration as predictive biomarker for ectopic pregnancy.

    Science.gov (United States)

    Dhiman, Pooja; Senthilkumar, G P; Rajendiran, Soundravally; Sivaraman, K; Soundararaghavan, S; Kulandhasamy, Maheshwari

    2016-05-01

    We evaluated the diagnostic accuracy of activin B in discriminating tubal ectopic pregnancy (tEP) from intrauterine miscarriages (IUM), and normal viable intrauterine pregnancy (IUP). We included 28 women with tEP, 31 women with IUM, and 29 normal IUP, confirmed both by clinical examination and ultrasonography. Serum activin B concentration was measured at the time of admission using the ELISA kit. The median serum activin B concentration was found to be significantly decreased in both tEP (p=0.004) and IUM (p=0.022) compared to normal IUP. When compared between tEP and IUM, activin B concentrations did not differ significantly. ROC analysis of activin B and free β-hCG demonstrated AUC of 0.722 and 0.805, respectively to discriminate tEP from viable IUP. The model including both activin B and free β-hCG improved the discriminating potential with greater AUC (0.824), and specificity (93%) than individual one. To discriminate tEP from IUM, activin B, free β-hCG and combination of both performed poorly. We conclude that serum activin B concentration is lower in tubal ectopic pregnancy, and can discriminate it from normal pregnancy with moderate accuracy. It also shows improved diagnostic potential along with free β-hCG, but cannot distinguish tEP from IUM reliably. Copyright © 2016. Published by Elsevier Inc.

  6. Kinetic of the gas-phase reactions of OH radicals and Cl atoms with Diethyl Ethylphosphonate and Triethyl Phosphate

    KAUST Repository

    Laversin, H.

    2015-11-30

    In this paper, the relative-rate technique has been used to obtain rate coefficients for the reaction of two organophosphorus compounds: Triethyl phosphate (TEP) and Diethyl ethylphosphonate (DEEP) with OH radicals and Cl atoms at atmospheric pressure and at different temperatures. The calculated rate constants were fitted to the Arrhenius expression over the temperature range 298 – 352 K. The following expressions (in cm3molecule-1s-1) were obtained for the reactions of OH and CL with DEEP and TEP: kOH+DEEP= (7.84±0.65)x10-14exp((1866±824)/T), kOH+TEP = (6.54±0.42)x10-14exp((1897±626)/T), kCl+DEEP = (5.27± 0.80)x10−11exp(765±140/T) and kCl+TEP = (5.23± 0.80)x10−11exp(736± 110/T). These results show that the reaction of the studied compounds with Cl atoms proceeds more rapidly than that with OH radicals. The related tropospheric lifetimes suggest that once emitted into the atmosphere, TEP and DEEP can be removed within a few hours in areas close to their emission sources. TEP and DEEP are principally removed by OH radicals. However, in coastal areas where the Cl atoms’ concentration is higher, TEP and DEEP removal by reaction with Cl atoms could be a competitive process.

  7. Effects of transparent exopolymer particles and muddy terrigenous sediments on the survival of hard coral recruits

    Science.gov (United States)

    Fabricius, K. E.; Wild, C.; Wolanski, E.; Abele, D.

    2003-07-01

    Sedimentation is a major cause of mortality in scleractinian coral recruits. In this study, we compared the effects of muddy coastal sediments, with and without enrichment by 'marine snow', on the survivorship of recruits of the hard coral Acropora willisae. Transparent exopolymer particles (TEP) were measured as characteristic components of marine snow using a staining method (Passow & Alldredge, Limnol. Oceangr. 40 (1995) 1326). Four-week-old recruits were exposed to: (1) muddy coastal sediments; (2) TEP; (3) TEP-enriched muddy coastal sediments; and (4) unfiltered sea water, for 43 h in aerated flow chambers. Thirty-three percent (±5 SE) of coral recruits died after 43-h exposure to TEP-enriched muddy coastal sediments (˜14 mg cm -2 sediments enriched with 3.8 ± 0.2 μg cm -2 gum xanthan equivalents (GX) TEP). In contrast, no or minimal mortality was observed in the other three treatments. Mortality increased to >80% when the amount of deposited TEP was almost tripled (10.9 ± 1.3 μg cm -2 GX) and sediment increased by 50%. Thus, coral recruits survived short-term exposure to low levels of TEP and low levels of muddy sediments, but sediments enriched with TEP at concentrations recorded at some of the inshore stations proved to be detrimental. Concentrations of TEP were measured in the central Great Barrier Reef (latitude 16-18°S) in summer, the season of coral spawning and recruitment. Within reefs >40 km off the coast. Our study suggests that both sediment composition and short-term (43 h) sediment deposition affect survival of coral juveniles, which has implications for the capacity of inshore reefs to be recolonised by corals to recover from acute disturbance events.

  8. Tris(2-butoxyethyl)phosphate and triethyl phosphate alter embryonic development, hepatic mRNA expression, thyroid hormone levels, and circulating bile acid concentrations in chicken embryos

    Energy Technology Data Exchange (ETDEWEB)

    Egloff, Caroline [National Wildlife Research Centre, Environment Canada, Ottawa, ON K1A 0H3 (Canada); Crump, Doug, E-mail: doug.crump@ec.gc.ca [National Wildlife Research Centre, Environment Canada, Ottawa, ON K1A 0H3 (Canada); Porter, Emily; Williams, Kim L.; Letcher, Robert J.; Gauthier, Lewis T. [National Wildlife Research Centre, Environment Canada, Ottawa, ON K1A 0H3 (Canada); Kennedy, Sean W. [National Wildlife Research Centre, Environment Canada, Ottawa, ON K1A 0H3 (Canada); Department of Biology, University of Ottawa, Ottawa, ON K1N 6N5 (Canada)

    2014-09-15

    The organophosphate flame retardants tris(2-butoxyethyl) phosphate (TBOEP) and triethyl phosphate (TEP) are used in a wide range of applications to suppress or delay the ignition and spread of fire. Both compounds have been detected in the environment and TBOEP was recently measured in free-living avian species. In this study, TBOEP and TEP were injected into the air cell of chicken embryos at concentrations ranging from 0 to 45,400 ng/g and 0 to 241,500 ng/g egg, respectively. Pipping success, development, hepatic mRNA expression of 9 target genes, thyroid hormone levels, and circulating bile acid concentrations were determined. Exposure to the highest doses of TBOEP and TEP resulted in negligible detection of the parent compounds in embryonic contents at pipping indicating their complete metabolic degradation. TBOEP exposure had limited effects on chicken embryos, with the exception of hepatic CYP3A37 mRNA induction. TEP exposure decreased pipping success to 68%, altered growth, increased liver somatic index (LSI) and plasma bile acids, and modulated genes associated with xenobiotic and lipid metabolism and the thyroid hormone pathway. Plasma thyroxine levels were decreased at all TEP doses, including an environmentally-relevant concentration (8 ng/g), and gallbladder hypotrophy was evident at ≥ 43,200 ng/g. Tarsus length and circulating thyroxine concentration emerged as potential phenotypic anchors for the modulation of transthyretin mRNA. The increase in plasma bile acids and LSI, gallbladder hypotrophy, and discoloration of liver tissue represented potential phenotypic outcomes associated with modulation of hepatic genes involved with xenobiotic and lipid metabolism. - Highlights: • TBOEP is not embryolethal to chicken embryos. • TEP affected embryonic viability, morphometric endpoints, and thyroid hormone levels. • TEP altered mRNA levels of xenobiotic and lipid metabolism genes. • TEP increased plasma bile acids and caused gallbladder hypotrophy

  9. Changes of Dielectric Properties induced by Fast neutrons in Tissue Equivalent Plastic A-150

    International Nuclear Information System (INIS)

    Abdou, M.S.

    2000-01-01

    Tissue equivalent plastic A-150 (TEP A-150) samples are exposed to fast neutrons. Dielectric studies for TEP A-150 are carried out in the frequency range from 40 Hz to 4 MHz in the temperature range 295-343 K. The obtained data revealed that, both the dielectric properties and conductivity sigma ac (omega) of TEP A-150 are altered when irradiated by a relatively high fast neutron dose (15 Sv). The values of dielectric constant and conductivity are increased for the irradiated samples to about 24% than the blank samples

  10. Agroforestry systems in northern Vietnam with Tephrosia candida as an alternative to short-fallow crop rotations

    Energy Technology Data Exchange (ETDEWEB)

    Hoang Fagerstroem, M.H. [Swedish Univ. of Agricultural Sciences, Uppsala (Sweden). Dept. of Soil Sciences

    2000-07-01

    Tephrosia candida was experimentally tested on-farm as an improved fallow species (TepFa), in hedgerows, (TepAl) and in a mulch transfer system (TepMu) in an upland rice (Oryza sativa) system on sloping land in northern Vietnam during the period 1996-1999. The objectives of this study were: (1) to investigate whether the existing monocropping (Mono) and short-fallow crop rotations (NaFa) are sustainable systems with respect to soil erosion and concomitant nutrient losses; (2) to determine whether agroforestry systems with Tephrosia (TepFa, TepAl, TepMu) can improve nutrient cycling and nutrient balances, for instance by preventing nutrient losses through erosion, as well as sustaining upland rice yields. A criteria system, including soil and nutrient losses, nutrient balances, changes of P-available pools, returns on labour and farmers' response, was used for comparing the systems tested. Only TepFa gave a positive input-output balance for both P and N. TepFa increased soil N and seemed to positively affect the release of soil labile P. However, the cost of Tephrosia seeds made the Net Present Value (NPV) of the Tephrosia fallow crop rotation system negative. TepMu increased upland rice yield by 50% compared to Mono. As a result, NPV was positive and sufficient rice for one more person could be produced per ha and year. However, the yield increase could cause a depletion of plant-available P, and the timing for pruning and mulching activities coincided with the farming activities in paddy fields. TepAl increased soil N, gave a neutral overall effect on crop yield but a negative NPV. NaFa gave a positive and highest NPV. In general, TepFa and TepMu were shown to increase crop yield per hectare with acceptable returns on labour and also to do better than Mono and NaFa with respect to preventing soil and nutrient losses through erosion. Recommendations are made for further research to focus on alternatives to maintain soil P, mechanisms of P pool reallocation and

  11. Mini MAX - Medicaid Sample

    Data.gov (United States)

    U.S. Department of Health & Human Services — To facilitate wider use of MAX, CMS contracted with Mathematica to convene a technical expert panel (TEP) and determine the feasibility of creating a sample file for...

  12. Quantitative Method for the Detection of Triethyl Phosphate in Aqueous Solutions

    National Research Council Canada - National Science Library

    Bagalawis, Rosa

    2003-01-01

    ...) at the parts per million level in aqueous solution. TEP was used as a chemical agent simulant to evaluate the penetration characteristics of clothing, gloves, boots and items of personal equipment...

  13. 76 FR 74121 - Medicare and Medicaid Programs: Hospital Outpatient Prospective Payment; Ambulatory Surgical...

    Science.gov (United States)

    2011-11-30

    ... Business Administration SCH Sole Community Hospital SDP Single Drug Pricer SI Status Indicator TEP... Programs: Hospital Outpatient Prospective Payment; Ambulatory Surgical Center Payment; Hospital Value-Based... Programs: Hospital Outpatient Prospective Payment; Ambulatory Surgical Center Payment; Hospital Value-Based...

  14. Experiencia y resultados de la herniorrafia inguinal por laparoscopia

    Directory of Open Access Journals (Sweden)

    Héctor René Hazbón

    2017-07-01

    Conclusión. La herniorrafia por laparoscopia con técnica TAPP es un procedimiento seguro; esta tiene tasas similares de efectividad y complicaciones a la técnica abierta y totalmente extraperitoneal TEP.

  15. Protein: FBA5 [TP Atlas

    Lifescience Database Archive (English)

    Full Text Available FBA5 VSP(voltage-sensor containing phosphatase) PTEN MMAC1, TEP1 PTEN_(gene) Phosph...atidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Mutated in mu

  16. Transmission Expansion Planning – A Multiyear Dynamic Approach Using a Discrete Evolutionary Particle Swarm Optimization Algorithm

    Directory of Open Access Journals (Sweden)

    Saraiva J. T.

    2012-10-01

    Full Text Available The basic objective of Transmission Expansion Planning (TEP is to schedule a number of transmission projects along an extended planning horizon minimizing the network construction and operational costs while satisfying the requirement of delivering power safely and reliably to load centres along the horizon. This principle is quite simple, but the complexity of the problem and the impact on society transforms TEP on a challenging issue. This paper describes a new approach to solve the dynamic TEP problem, based on an improved discrete integer version of the Evolutionary Particle Swarm Optimization (EPSO meta-heuristic algorithm. The paper includes sections describing in detail the EPSO enhanced approach, the mathematical formulation of the TEP problem, including the objective function and the constraints, and a section devoted to the application of the developed approach to this problem. Finally, the use of the developed approach is illustrated using a case study based on the IEEE 24 bus 38 branch test system.

  17. The feasibility and safety of single-incision totally extraperitoneal inguinal hernia repair after previous lower abdominal surgery: 350 procedures at a single center.

    Science.gov (United States)

    Wakasugi, Masaki; Suzuki, Yozo; Tei, Mitsuyoshi; Anno, Kana; Mikami, Tsubasa; Tsukada, Ryo; Koh, Masahiro; Furukawa, Kenta; Masuzawa, Toru; Kishi, Kentaro; Tanemura, Masahiro; Akamatsu, Hiroki

    2017-03-01

    To evaluate the feasibility and safety of single-incision laparoscopic surgery for totally extraperitoneal inguinal hernia repair (SILS-TEP) with previous lower abdominal surgery (PLAS). A retrospective analysis of 350 patients undergoing SILS-TEP for a primary inguinal hernia from January 2012 to December 2015 at Osaka Police Hospital was performed, and the outcomes of the patients with and without PLAS were compared. SILS-TEP was performed in 84 patients with PLAS and 266 patients without PLAS. Appendectomy was the most common previous operative procedure. There were more patients with an ASA score of ≥3 in the PLAS group than in the control group (p < 0.05). The mean operative time, and the rates of conversion and postoperative complications were comparable between the two groups. There were no cases of recurrence in either group. SILS-TEP could be safely performed in patients with PLAS and achieved better cosmetic outcomes than conventional laparoscopic surgery.

  18. Simple electric powered plankton wheel for the production of aggregates in seawater on-board ship

    Digital Repository Service at National Institute of Oceanography (India)

    Damare, V.S.; Khalap, S.; Seshagiri, R.

    natural environment is important as during the process it is necessary to retain the structural integrity of an aggregate. Though turbulence facilitates colloidal fibrils and TEPs to coagulate, resulting in formation of larger aggregates9...

  19. Final Programmatic Environmental Impact Statement for Defense Threat Reduction Agency (DTRA) Activities on White Sands Missile Range, New Mexico. Volume 1

    Science.gov (United States)

    2007-03-01

    bean, radish, wheat, tomato , sugar beet, meadow fescue, and rose). An effect level for phytotoxicity was established at a concentration of 50 ppm...White Sands Missile Range FPEIS F-30 TEP was shown to cause a decrease in plant growth at greater than 400 mg TEP/m2 for tomatoes , sorghum...decomposition products as oxides of oxide. If the product is heated to temperatures sufficient to produce smoke or fumes the TLV-TWA for rosin pyrolysis

  20. Novel thermal imaging analysis technique for detecting inflammation in thyroid eye disease.

    Science.gov (United States)

    Di Maria, Costanzo; Allen, John; Dickinson, Jane; Neoh, Christopher; Perros, Petros

    2014-12-01

    The disease phase in thyroid eye disease (TED) is commonly assessed by clinical investigation of cardinal signs of inflammation and using the clinical activity score (CAS). Although CAS is the current gold standard, the clinical assessment would benefit if a more objective tool were available. The aim of this work was to explore the clinical value of a novel thermal imaging analysis technique to objectively quantify the thermal characteristics of the eye and peri-orbital region and determine the disease phase in TED. This was a cross-sectional study comparing consecutive patients with active TED (CAS ≥ 3/7) attending a tertiary center, with a group of consecutive patients with inactive TED (CAS <3). Thermal images were acquired from 30 TED patients, 17 with active disease and 13 with inactive disease. Patients underwent standard ophthalmological clinical assessments and thermal imaging. Five novel thermal eye parameters (TEP) were developed to quantify the thermal characteristics of the eyes in terms of the highest level of inflammation (TEP1), overall level of inflammation (TEP2), right-left asymmetry in the level of inflammation (TEP3), maximum temperature variability across the eyes (TEP4), and right-left asymmetry in the temperature variability (TEP5). All five TEP were increased in active TED. TEP1 gave the largest accuracy (77%) at separating the two groups, with 65% sensitivity and 92% specificity. A statistical model combining all five parameters increased the overall accuracy, compared to using only one parameter, to 93% (94% sensitivity and 92% specificity). All five of the parameters were also found to be increased in patients with chemosis compared to those without. The potential diagnostic value of this novel thermal imaging analysis technique has been demonstrated. Further investigation on a larger group of patients is necessary to confirm these results.

  1. Economic evaluation of laparoscopic and open inguinal herniorrhaphies: the effect of cost-containment measures and internal hospital policy decisions on costs and charges.

    Science.gov (United States)

    Khajanchee, Y S; Kenyon, T A G; Hansen, P D; Swanström, L L

    2004-08-01

    Totally extraperitoneal (TEP) repairs of inguinal hernias, despite having a favorable clinical outcome are often criticized due to higher costs and charges associated with this approach. We, therefore, present a comparison of direct costs and charges between TEP and open tension-free (OPN) repairs, emphasizing the effect of cost-containment measures on the part of surgeons and the hospital's charging (rate-setting) policies on these measurements. Itemized direct costs, charges, and reimbursements were determined for 41 TEP and 44 OPN unilateral repairs done between January 1997 and December 1999. Multiple sensitivity analyses were done to evaluate the effect of cost-containment measures and the hospital's rate-setting policies on the differences in costs and charges between the two procedures. The hospital's profits were expressed as profit-cost ratios. The mean direct cost for a TEP repair was $128.58 more than the OPN repair ($795.07[+/-65] vs 666.49 [+/-52]). However, mean charges and hospital reimbursement were $2,139.80 and $1,679.87, respectively, more for the TEP repairs. The profit-cost ratio was significantly higher in the TEP group (2.85:1 vs 1.07:1, Pcontainment measures. Forty-five percent of the difference in charges was due to the hospital's nonuniform rate-setting policies. Long-term follow-up (38 months) showed no recurrence for either procedure. The direct cost of TEP repairs with the minimal use of disposable instruments in a high-volume center is comparable to the OPN repair. However, due to differences in the hospital's charging policies, TEP repair would appear to be an expensive alternative from the payer's point of view.

  2. Prevention of Low Back Pain in The Military. A Randomized Clinical Trial

    Science.gov (United States)

    2011-07-01

    41 Initial Entry Training ( IET ), Low Back Pain (LBP) Core Stabilization Exercise Program (CSEP), Traditional Exercise Program (TEP), and...Soldiers in IET (n=7616) Met Inclusion/Exclusion Criteria (n=5875) TEP (c=5, m=248, r=191-297, n=1216) Ineligible (n=1741) Elected not to...Americans in diabetes research: lessons learned. Diabetes Educ 2000, 31(2):251-9. 6. Glasgow RE, Nelson CC, Kearney KA, Reid R, Ritzwoller DP, Strecher VJ

  3. Data Fusion Analysis For Test Validation System

    Science.gov (United States)

    2009-11-16

    triethyl phosphate (TEP), methyl salicylate (MeS), and acetic acid (AA). A total of 29 release scenarios were conducted: fifteen TEP releases of 30...and MeS classes and baseline problems continued. Note that the ppbRAE detectors responded well to acetic acid , as shown in Figure 23, though...baseline problems are apparent. The LCD sensors were not configured to detect acetic acid . 35 The temperature gradient with respect to height above

  4. The wood-energy. Wood-energy: self-feeding boilers; Le bois-energie. Bois-energie: chaufferies a alimentation automatique

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-06-01

    Today the wood-energy accounts a global consumption of 8 to 10 million tep (tons petroleum equivalent). 120000 tep is devoted to the ternary collective heating. More than 350 self-feeding boilers, implementing these last 15 years, are supplied with various resources: wood industry wastes, slashed wood. This guide presents informations and recommendations necessary to the implementing of a self-feeding boiler and brings concrete answers to the wood heating developers. (A.L.B.)

  5. Factor structure and construct validity of the temporal experience of pleasure scales.

    Science.gov (United States)

    Ho, Paul M; Cooper, Andrew J; Hall, Phillip J; Smillie, Luke D

    2015-01-01

    Feelings of pleasure felt in the moment of goal attainment (consummatory pleasure) are thought to be dissociable from feelings of desire connected with the motivated approach of goals (anticipatory pleasure). The Temporal Experience of Pleasure Scales (TEPS; Gard, Gard, Kring, & John, 2006) was developed to assess individual differences in these distinct processes. Recently, an independent evaluation of the psychometric characteristics of a Chinese-translated TEPS suggested a more complex factor structure (Chan et al., 2012). This study aimed to reexamine the factor structure and convergent and divergent validity of the TEPS in two previously unexamined multiethnic samples. University students in the United Kingdom (N = 294) completed the TEPS and university students in Australia (N = 295) completed the TEPS as well as a battery of conceptually related questionnaires. A confirmatory factor analysis of Gard et al.'s (2006) 2-factor model produced inadequate fit, which model-modification indexes suggested might be due to item cross-loadings. This issue was examined further using an exploratory factor analysis, which revealed a clear 2-factor solution despite cross-loadings among some items. Finally, mixed evidence for convergent-divergent validity was obtained, in terms of relationships between the TEPS and measures of anhedonia, approach-motivation, and positive emotion.

  6. Thermal and electric properties of Nd(1.85)Ce(0.15)CuO(4-y) and Pr(1.85)Ce(0.15)CuO(4-y)

    Science.gov (United States)

    Lim, Z. S.; Han, K. H.; Lee, Sung-Ik; Jeong, Yoon H.; Song, Y. S.; Park, Y. W.

    1991-01-01

    Electric resistivity, magnetic susceptibility, thermoelectric power, and Hall coefficient of Nd(1.85)Ce(0.15)CuO(4-y) and Pr(1.85)Ce(0.15)CuO(4-y) whose onset temperature of the superconductivity are 24 and 23 K were measured. Experimental results show many interesting features. In particular, the Hall coefficients are negative and relatively flat as a function of temperature. However, the temperature dependence of the thermoelectric power (TEP) for these two samples shows the positive sign for both samples in contrast to the previous results. Moreover, TEP for both samples remains flat in the normal state below 250 K, but decreases rapidly above 250 K. TEP of only Pr(1.85)Ce(0.15)CuO(4-y) shows a peak near 50 K. Finally, onset temperatures of sudden drop of TEP are higher than those of resistance drop. The physical properties of these samples produced at different conditions such as different heat treatment temperatures, atmospheres were also measured. TEP and resistance measurement show that oxygen deficiency is essential to produce better superconducting samples. Correlation between TEP and superconductivity for these different samples are discussed.

  7. A heterodimeric complex of the LRR proteins LRIM1 and APL1C regulates complement-like immunity in Anopheles gambiae

    Energy Technology Data Exchange (ETDEWEB)

    Baxter, Richard H.G.; Steinert, Stefanie; Chelliah, Yogarany; Volohonsky, Gloria; Levashina, Elena A.; Deisenhofer, Johann (CNRS-UMR); (UTSMC)

    2012-01-20

    The leucine-rich repeat (LRR) proteins LRIM1 and APL1C control the function of the complement-like protein TEP1 in Anopheles mosquitoes. The molecular structure of LRIM1 and APL1C and the basis of their interaction with TEP1 represent a new type of innate immune complex. The LRIM1/APL1C complex specifically binds and solubilizes a cleaved form of TEP1 without an intact thioester bond. The LRIM1 and APL1C LRR domains have a large radius of curvature, glycosylated concave face, and a novel C-terminal capping motif. The LRIM1/APL1C complex is a heterodimer with a single intermolecular disulfide bond. The structure of the LRIM1/APL1C heterodimer reveals an interface between the two LRR domains and an extensive C-terminal coiled-coil domain. We propose that a cleaved form of TEP1 may act as a convertase for activation of other TEP1 molecules and that the LRIM1/APL1C heterodimer regulates formation of this TEP1 convertase.

  8. Does ocean acidification induce an upward flux of marine aggregates?

    Directory of Open Access Journals (Sweden)

    X. Mari

    2008-07-01

    Full Text Available The absorption of anthropogenic atmospheric carbon dioxide (CO2 by the ocean provokes its acidification. This acidification may alter several oceanic processes, including the export of biogenic carbon from the upper layer of the ocean, hence providing a feedback on rising atmospheric carbon concentrations. The effect of seawater acidification on transparent exopolymeric particles (TEP driven aggregation and sedimentation processes were investigated by studying the interactions between latex beads and TEP precursors collected in the lagoon of New Caledonia. A suspension of TEP and beads was prepared and the formation of mixed aggregates was monitored as a function of pH under increasing turbulence intensities. The pH was controlled by addition of sulfuric acid. Aggregation and sedimentation processes driven by TEP were drastically reduced when the pH of seawater decreases within the expected limits imposed by increased anthropogenic CO2 emissions. In addition to the diminution of TEP sticking properties, the diminution of seawater pH led to a significant increase of the TEP pool, most likely due to swollen structures. A diminution of seawater pH by 0.2 units or more led to a stop or a reversal of the downward flux of particles. If applicable to oceanic conditions, the sedimentation of marine aggregates may slow down or even stop as the pH decreases, and the vertical flux of organic carbon may reverse. This would enhance both rising atmospheric carbon and ocean acidification.

  9. Simultaneous study by PET/CT of the proliferation, metabolism and tumoral hypoxia before and during an exclusive radiotherapy (R.T.) in patients suffering of anon at small cells bronco-pulmonary cancer (N.S.C.B.P.C.); Etude simultanee par TEP/TDM de la proliferation, du metabolisme et de l'hypoxie tumorale avant et pendant une radiotherapie exclusive (RT) chez les patients atteints d'un cancer broncho-pulmonaire non a petites cellules (CBPNPC)

    Energy Technology Data Exchange (ETDEWEB)

    Vera, P.; Edet-Sanson, A.; Bohn, P.; Salles, A.; Hapdey, S.; Gardin, I. [Centre Becquerel, QuantIF LITIS EA4108, service de medecine nucleaire, 76 - Rouen (France); Menard, J.F. [CHU de Rouen, QuantIF LITIS EA4108, service de statistique, 76 (France); Thiberville, L. [CHU de Rouen, clinique pneumologique, QuantIF LITIS EA4108, 76 (France); Dubray, B. [Centre Becquerel, QuantIF LITIS EA4108, service de radiotherapie, 76 - Rouen (France)

    2010-07-01

    Purpose: Simultaneous in vivo study by PET/CT of proliferation, metabolism and tumor hypoxia modifications before and during radiotherapy has never been realised in patients suffering of a bronco-pulmonary non at small cells cancer (C.B.P.N.P.C.). Conclusions: the quasi simultaneous realisation (in 4 to 7 days) of three PET/CT images before and during radiotherapy, in patients suffering of a C.B.P.N.P.C. appears feasible. At 2 Gy of the radiotherapy, proliferation reduces quickly, in the tumor and the mediastinum ganglions. this reduction appears more rapidly than the metabolism decrease. Hypoxia is more important in the tumor than in the ganglions, but does not vary during irradiation. (N.C.)

  10. The spectral features of EEG responses to transcranial magnetic stimulation of the primary motor cortex depend on the amplitude of the motor evoked potentials.

    Science.gov (United States)

    Fecchio, Matteo; Pigorini, Andrea; Comanducci, Angela; Sarasso, Simone; Casarotto, Silvia; Premoli, Isabella; Derchi, Chiara-Camilla; Mazza, Alice; Russo, Simone; Resta, Federico; Ferrarelli, Fabio; Mariotti, Maurizio; Ziemann, Ulf; Massimini, Marcello; Rosanova, Mario

    2017-01-01

    Transcranial magnetic stimulation (TMS) of the primary motor cortex (M1) can excite both cortico-cortical and cortico-spinal axons resulting in TMS-evoked potentials (TEPs) and motor-evoked potentials (MEPs), respectively. Despite this remarkable difference with other cortical areas, the influence of motor output and its amplitude on TEPs is largely unknown. Here we studied TEPs resulting from M1 stimulation and assessed whether their waveform and spectral features depend on the MEP amplitude. To this aim, we performed two separate experiments. In experiment 1, single-pulse TMS was applied at the same supra-threshold intensity on primary motor, prefrontal, premotor and parietal cortices and the corresponding TEPs were compared by means of local mean field power and time-frequency spectral analysis. In experiment 2 we stimulated M1 at resting motor threshold in order to elicit MEPs characterized by a wide range of amplitudes. TEPs computed from high-MEP and low-MEP trials were then compared using the same methods applied in experiment 1. In line with previous studies, TMS of M1 produced larger TEPs compared to other cortical stimulations. Notably, we found that only TEPs produced by M1 stimulation were accompanied by a late event-related desynchronization (ERD-peaking at ~300 ms after TMS), whose magnitude was strongly dependent on the amplitude of MEPs. Overall, these results suggest that M1 produces peculiar responses to TMS possibly reflecting specific anatomo-functional properties, such as the re-entry of proprioceptive feedback associated with target muscle activation.

  11. Stochastic modelling of optimum initial body weight, daily weight gain and effect of genetic changes in ovulation rate and age at sexual maturity on total egg production of broiler breeders.

    Science.gov (United States)

    Alvarez, R; Hocking, P M

    2009-01-01

    1. A model that simulates the total production of eggs (TEP) in broiler breeders was used to predict the optimum initial (20 week) body weight (IBWexp), daily weight gains from 20 to 30 (DWGexp(20-30)) and 31 to 62 weeks of age (DWGexp(31-62)), age at photostimulation (affecting age at first egg, AFEexp), coefficients of variation of initial body weight (CV-IBWexp) and age at first egg (CV-AFEexp), and the effect of genetically increasing the numbers of yellow follicles at the onset of lay. 2. The results suggest that TEP in broiler breeders is very sensitive to changes in body weight gain during the first 10 weeks of the production period and body weight at the start of egg production, whereas changes in body weight gain after peak rate of lay showed only minor effects on TEP. Increasing CV-IBWexp was associated with a linear decrease in the mean and increased variability of TEP. 3. Decreasing AFEexp was negatively associated with TEP, whereas higher CV-AFEexp increased variability of TEP and had a trivial affect on the mean. 4. Results of the simulation suggested that reducing ovarian yellow follicle numbers by means of genetic selection could reduce the degree of feed restriction currently used in broiler breeder commercial stocks while maintaining total egg production. Higher numbers of yellow follicles associated with selection for higher growth rate would not result in lower egg production if the body weight target was maintained at the currently recommended commercial level and the effect on TEP of increasing the target in proportion to potential body weight may be relatively small.

  12. Integrated generation- transmission expansion planning: a review of the state of the art

    Directory of Open Access Journals (Sweden)

    Sergio D. Saldarriaga-Zuluaga

    2016-07-01

    Full Text Available In the last decade a great number of research works have approached the power systems planning problem by coordinating in a single optimization problem the generation expansion planning (GEP and the transmission expansion planning (TEP. GEP is usually carried out disregarding network constraints and under an energetic perspective. On the other hand, TEP aims to find network reinforcements that meet the expected demand in an economical and reliable way. The integration of these problems has been approached using different methods, models, and objective functions. This paper presents an exhaustive review of the integrated GEP-TEP problem from different points of view such as modeling, solving methods, reliability considerations, among others. There are review papers in the specialized literature that characterize the GEP and TEP problem independently. However, there are no reviews regarding the integrated GEP-TEP problem. So, it is needed to characterize aspects of the power systems integrated planning problem with the aim to provide consulting tools for researchers in this field.

  13. Lichtenstein Versus Total Extraperitoneal Patch Plasty Versus Transabdominal Patch Plasty Technique for Primary Unilateral Inguinal Hernia Repair: A Registry-based, Propensity Score-matched Comparison of 57,906 Patients.

    Science.gov (United States)

    Köckerling, Ferdinand; Bittner, Reinhard; Kofler, Michael; Mayer, Franz; Adolf, Daniela; Kuthe, Andreas; Weyhe, Dirk

    2017-09-26

    Outcome comparison of the Lichtenstein, total extraperitoneal patch plasty (TEP), and transabdominal patch plasty (TAPP) techniques for primary unilateral inguinal hernia repair. For comparison of these techniques the number of cases included in meta-analyses of randomized controlled trials is limited. There is therefore an urgent need for more comparative data. In total, 57,906 patients with a primary unilateral inguinal hernia and 1-year follow up from the Herniamed Registry were selected between September 1, 2009 and February 1, 2015. Using propensity score matching, 12,564 matched pairs were formed for comparison of Lichtenstein versus TEP, 16,375 for Lichtenstein versus TAPP, and 14,426 for TEP versus TAPP. Comparison of Lichtenstein versus TEP revealed disadvantages for the Lichtenstein operation with regard to the postoperative complications (3.4% vs 1.7%; P comparison of Lichtenstein versus TAPP showed disadvantages for the Lichtenstein operation with regard to the postoperative complications (3.8% vs 3.3%; P = 0.029), complication-related reoperations (1.2% vs 0.9%; P = 0.019), pain at rest (5% vs 4.5%; P = 0.029), and on exertion (10.2% vs 7.8%; P < 0.001). TEP and TAPP were found to have advantages over the Lichtenstein operation.

  14. Study of the solubility of iron in zirconium by thermoelectric power measurements

    International Nuclear Information System (INIS)

    Borrelly, R.; Merle, P.; Adami, L.; Centre National de la Recherche Scientifique, 69 - Villeurbanne

    1990-01-01

    Thermoelectric power (TEP) measurements are used to determine the solubility of iron in α-zirconium. A preliminary study shows that TEP is very sensitive to elements in solid solution, to cold-working and to the texture due to rolling in a temperature range including room temperature which is choosen for thermoelectric power measurements. The solutioning of iron obtained by a homogenization treatment and water-quench leads to a decrease of thermoelectric power. The conditions of homogenization treatments such that TEP variations are only due to the variation of iron content in solid solution have been determined. From these results the solubility of iron α-zirconium as a function of temperature has been determined. Moreover, the α-domain of the Zr-rich part of the Zr-Fe diagram has been completely delimited. A micrographic study has been made to confirm these results. (orig.)

  15. Achados clínicopatológicos na tromboembolia pulmonar: estudo de 24 anos de autópsias Clinicopathological findings in pulmonary thromboembolism: a 24-year autopsy study

    Directory of Open Access Journals (Sweden)

    Hugo Hyung Bok Yoo

    2004-10-01

    Full Text Available INTRODUÇÃO: Tromboembolia pulmonar (TEP é ainda uma afecção enigmática em diversos aspectos clínicos e epidemiológicos e frequentemente erroneamente diagnosticada. OBJETIVO: Descrever a prevalência e os achados anatomopatológicos de TEP em uma série de 5261 autópsias realizadas em um hospital universitário de nível terciário, correlacionar estes achados com as doenças de base e verificar a freqüência de suspeita clínica antemortem de TEP. MÉTODO: Revisão dos registros das autópsias consecutivas realizadas de 1979 a 2002 para um estudo retrospectivo. Dos prontuários e dos relatórios de autópsias dos pacientes que tiveram TEP documentada, macro e/ou microscopicamente, foram extraídos dados demográficos, doenças de base, suspeita antemortem de TEP, localização dos trombos nos pulmões e provável local de origem da TEP. RESULTADOS: A freqüência de autópsias foi de 42,0% e TEP foi encontrada em 544 pacientes, sendo a principal causa da morte (TEP fatal em 225 casos. Doenças infecciosas (p=0,0003 foram associadas com TEP não fatal e trauma (p=0,007 com TEP fatal. A taxa de não suspeita antemortem de TEP foi 84,6% e 40,0% destes pacientes apresentaram TEP fatal. Doenças do sistema circulatório (p=0,0001, infecções (pBACKGROUND: Pulmonary thromboembolism (PTE is still an enigmatic disorder in many epidemiological and clinical features, remaining one of the most commonly misdiagnosed disorders. OBJECTIVE: To describe the prevalence and pathological findings of PTE in a series of autopsies, to correlate these findings with underlying diseases, and to verify the frequency of PTE clinically suspected before death. METHOD: The reports on 5261 consecutive autopsies performed from 1979 to 2002 in a Brazilian tertiary referral medical school were reviewed for a retrospective study. From the medical records and autopsy reports of the patients found with macroscopically and/or microscopically documented PTE, were gathered

  16. Transmission expansion in an oligopoly considering generation investment equilibrium

    DEFF Research Database (Denmark)

    Taheri, S. Saeid; Kazempour, Jalal; Seyedshenava, Seyedjalal

    2017-01-01

    Transmission expansion planning (TEP) is a sophisticated decision-making problem, especially in an oligopolistic electricity market in which a number of strategic (price-maker) producers compete together. A transmission system planner, who is in charge of making TEP decisions, requires considering...... the future generation investment actions. However, in such an oligopolistic market, each producer makes its own strategic generation investment decisions. This motivates the transmission system planner to consider the generation investment decision-making problem of all producers within its TEP model....... The strategic generation investment problem of each producer can be represented by a complementarity bi-level model. The joint consideration of all bi-level models, one per producer, characterizes the generation investment equilibrium that identifies the future evolution of generation investment in the market...

  17. Impact of changes in broth composition on Chlorella vulgaris cultivation in a membrane photobioreactor (MPBR) with permeate recycle.

    Science.gov (United States)

    Discart, V; Bilad, M R; Marbelia, L; Vankelecom, I F J

    2014-01-01

    A membrane photobioreactor (MPBR) is a proven and very useful concept in which microalgae can be simultaneously cultivated and pre-harvested. However, the behavior with respect to accumulation of algogenic organic matter, including transparent exopolymeric particles (TEPs), counter ions and unassimilated nutrients due to the recycling of the medium is still unclear, even though the understanding of this behavior is essential for the optimization of microalgae processing. Therefore, the dynamics of these compounds, especially TEPs, during coupled cultivation and harvesting of Chlorella vulgaris in an MPBR with permeate recycle are addressed in this study. Results show that TEPs are secreted during algae cell growth, and that their presence is thus inevitable. In the system with permeate recycle, substances such as counter ions and unassimilated nutrients get accumulated in the system. This was proven to limit the algae growth, together with the occurrence of bioflocculation due to an increasing broth pH. Copyright © 2013 Elsevier Ltd. All rights reserved.

  18. Role of charged impurities in thermoelectric transport in molybdenum disulfide monolayers

    Science.gov (United States)

    Patil, Sukanya B.; Sankeshwar, N. S.; Mulimani, B. G.

    2017-12-01

    A theoretical study of the electronic properties, namely, electrical conductivity (EC), electronic thermal conductivity (ETC) and thermoelectric power (TEP) in 2D MoS2 monolayers (MLs), over a wide range of temperatures (10  determining the properties of supported MLs is demonstrated for the first time. Validity of Wiedemann–Franz law and Mott formula are examined for supported and free standing MLs. Calculations are in consonance with recent experimental data on mobility and TEP of exfoliated SiO2-supported MoS2 ML samples. In the case of TEP it is found that though the diffusion contribution is dominant the inclusion of the drag component, incorporating contributions from all relevant phonon scattering mechanisms, is needed to obtain good agreement with the data.

  19. A structured, extended training program to facilitate adoption of new techniques for practicing surgeons.

    Science.gov (United States)

    Greenberg, Jacob A; Jolles, Sally; Sullivan, Sarah; Quamme, Sudha Pavuluri; Funk, Luke M; Lidor, Anne O; Greenberg, Caprice; Pugh, Carla M

    2018-01-01

    Laparoscopic inguinal hernia repair has been shown to have significant benefits when compared to open inguinal hernia repair, yet remains underutilized in the United States. The traditional model of short, hands-on, cognitive courses to enhance the adoption of new techniques fails to lead to significant levels of practice implementation for most surgeons. We hypothesized that a comprehensive program would facilitate the adoption of laparoscopic inguinal hernia repair (TEP) for practicing surgeons. A team of experts in simulation, coaching, and hernia care created a comprehensive training program to facilitate the adoption of TEP. Three surgeons who routinely performed open inguinal hernia repair with greater than 50 cases annually were recruited to participate in the program. Coaches were selected based on their procedural expertise and underwent formal training in surgical coaching. Participants were required to evaluate all aspects of the educational program and were surveyed out to one year following completion of the program to assess for sustained adoption of TEP. All three participants successfully completed the first three steps of the seven-step program. Two participants completed the full course, while the third dropped out of the program due to time constraints and low case volume. Participant surgeons rated Orientation (4.7/5), GlovesOn training (5/5), and Preceptored Cases (5/5) as highly important training activities that contributed to advancing their knowledge and technical performance of the TEP procedure. At one year, both participants were performing TEPs for "most of their cases" and were confident in their ability to perform the procedure. The total cost of the program including all travel, personal coaching, and simulation was $8638.60 per participant. Our comprehensive educational program led to full and sustained adoption of TEP for those who completed the course. Time constraints, travel costs, and case volume are major considerations for

  20. Reducing DNACPR complaints to zero: designing and implementing a treatment escalation plan using quality improvement methodology.

    Science.gov (United States)

    Shermon, Elizabeth; Munglani, Laura; Oram, Sarah; William, Linda; Abel, Julian

    2017-01-01

    Do Not Attempt Resuscitation (DNAR)decisions have traditionally formed the basis of ceiling of care discussions. However, poor quality discussions can lead to high patient and relative dissatisfaction, generating hospital complaints. Treatment escalation plans (TEPs) aim to highlight the wider remit of treatment options with a focus on effective communication. We aimed to improve TEP discussions and documentation at Weston General Hospital by introducing a standardised form. We aimed to develop a TEP document to reduce resuscitation-related complaints by improving communication and documentation. Qualitative and quantitative data were collected over 2 years and used to develop plan-do-study-act (PDSA) cycles using quality improvement methodology. Main barriers to improvement included time constraints and clinician's resistance. Analysis of patient liaison services data showed a progressive reduction in complaints regarding resuscitation, with no complaints having been received for the final six months of the project. Through use of a standardised form including treatment prompts, the quality of discussions and plans improved. Qualitative feedback demonstrated increased patient and relative satisfaction. In addition, junior doctors report the plans are helpful when making out-of-hours decisions. Development of a user-friendly form to document patient-guided TEPs helped junior doctors to lead advanced care planning discussions. The use of PDSA cycles demonstrated improvement in the quality of forms, which in turn improved communication, documentation and satisfaction. Future developments could include involvement of specialist teams to ensure TEP forms remain relevant to all clinical areas. In addition, with widespread use of the TEP forms, the traditional tick-box DNAR could be replaced to focus on patient-led care planning.

  1. Effect of heterogeneities on the thermoelectric power of pressure vessel steel

    International Nuclear Information System (INIS)

    In service working conditions, the vessel of the Pressurized Water Reactors (PWR) undergoes an ageing due to irradiation. In order to follow the evolution of the mechanical characteristics of the steel in service, EDF launched a surveillance program which consists to carry out mechanical tests on samples aged in reactor. However, the results of these tests have the disadvantage to be affected by the presence of heterogeneities within the steel. Indeed, because of its manufacturing process, the steel contains segregated areas. Thus, EDF launched Thermoelectric Power Measurements (TEP) on the resilience samples of the surveillance program, to complete the mechanical tests and to help with their interpretation. However, these measurements are today difficult to analyse because they include at the same time the effect of the irradiation and the effect of the metallurgical heterogeneities. The aim of this work consisted in evaluating the effect of the heterogeneities on the TEP of the non-irradiated vessel steel. For that, a numerical model was developed which allows to calculate the TEP of a composite structure. We have shown that the model is pertinent to highlight the effect of the heterogeneities on the TEP of the vessel steel, which is considered like a 'matrix'/'segregation' composite. The model allowed us to put emphasis on the influence of different parameters on the TEP measurement. We have thus showed that the measurements conditions have an important effect on the obtained TEP value (influence of the applied pressure, the position of the sample on the device, the site of the metallurgical heterogeneities,...). (author)

  2. Laparoscopic total extraperitoneal repair under spinal anesthesia versus general anesthesia: a randomized prospective study

    Directory of Open Access Journals (Sweden)

    Donmez T

    2016-10-01

    Full Text Available Turgut Donmez,1 Vuslat Muslu Erdem,2 Oguzhan Sunamak,3 Duygu Ayfer Erdem,2 Huseyin Imam Avaroglu1 1Department of General Surgery, 2Department of Anesthesiology and Reanimation, Lutfiye Nuri Burat State Hospital, 3Department of General Surgery, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey Background: Laparoscopic total extraperitoneal (TEP inguinal hernia repair is a well-known approach to inguinal hernia repair that is usually performed under general anesthesia (GA. To date, no reports compare the efficacy of spinal anesthesia (SA with that of GA for laparoscopic hernia repairs. The purpose of this study was to compare the surgical outcome of TEP inguinal hernia repair performed when the patient was treated under SA with that performed under GA. Materials and methods: Between July 2015 and July 2016, 50 patients were prospectively randomized to either the GA TEP group (Group I or the SA TEP group (Group II. Propofol, fentanyl, rocuronium, sevoflurane, and tracheal intubation were used for GA. Hyperbaric bupivacaine (15 mg and fentanyl (10 µg were used for SA to achieve a sensorial level of T3. Intraoperative events related to SA, operative and anesthesia times, postoperative complications, and pain scores were recorded. Each patient was asked to evaluate the anesthetic technique by using a direct questionnaire filled in 3 months after the operation. Results: All the procedures were completed by the allocated method of anesthesia as there were no conversions from SA to GA. Pain was significantly less for 1 h (P<0.0001 and 4 h (P=0.002 after the procedure for the SA and GA groups, respectively. There was no difference between the two groups regarding complications, hospital stay, recovery, or surgery time. Generally, patients were more satisfied with SA than GA (P<0.020. Conclusion: TEP inguinal hernia repair can be safely performed under SA, and SA was associated with less postoperative pain, better recovery, and better

  3. Reduced Short-Latency Afferent Inhibition in Prefrontal but not Motor Cortex and Its Association With Executive Function in Schizophrenia: A Combined TMS-EEG Study.

    Science.gov (United States)

    Noda, Yoshihiro; Barr, Mera S; Zomorrodi, Reza; Cash, Robin F H; Rajji, Tarek K; Farzan, Faranak; Chen, Robert; George, Tony P; Daskalakis, Zafiris J; Blumberger, Daniel M

    2018-01-13

    Cholinergic dysfunction is increasingly assumed to be involved in the pathophysiology of schizophrenia. Short-latency afferent inhibition (SAI) is a transcranial magnetic stimulation (TMS) paradigm that has been shown to assay central cholinergic activity from the motor cortex (M1). Recently, we established a method to index SAI from the dorsolateral prefrontal cortex (DLPFC), an area implicated in the pathophysiology of schizophrenia. We investigated SAI in M1 and DLPFC in schizophrenia. We hypothesized that modulation of N100 on TMS-evoked potentials (TEPs) from the DLPFC would be attenuated in patients with schizophrenia compared to healthy controls. SAI was examined in 12 patients, whose age was matched to controls, using TMS combined with electroencephalography (EEG). SAI was recorded with TMS applied to left M1 (M1-SAI) and DLPFC (DLPFC-SAI). For group comparison, we used the SAI data of healthy participants in our previous study. In patients, N100 TEP was significantly attenuated with DLPFC-SAI, whereas P180 TEP was significantly increased with M1-SAI. Between patients and controls, there were significant differences in modulation of P180 TEP by M1-SAI (t22 = -2.748, P = .012; patients > controls) and N100 TEP by DLPFC-SAI (t22 = 5.456, P < .0001; patients < controls). Further, modulation of N100 TEP by DLPFC-SAI significantly correlated with executive function (r = -.740, P = .006, N = 12). Our findings suggest that DLPFC-SAI but not M1-SAI were reduced in patients with schizophrenia and this was linked to deficits in cognition. This may reflect prefrontal cholinergic deficits and represent a biomarker for cholinergic and executive dysfunction in patients with schizophrenia. © The Author(s) 2017. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  4. ESA's Food Security Thematic Exploitation Platform "Supporting Sustainable Food Production from Space"

    Science.gov (United States)

    Gilliams, S. J.

    2017-12-01

    In line with the paradigm shift in Earth Observation of "Bringing the users to the data", ESA provides collaborative, virtual work environments giving access to EO data and tools, processors, and ICT resources through coherent interfaces. These coherent interfaces are categorized thematically, tailored to the related user communities and named Thematic Exploitation Platforms (TEP). The Food Security Thematic Exploitation Platform (FS-TEP) is the youngest out of seven TEPs and is developed in an agile mode in close coordination with its users. It will provide a "one stop platform" for the extraction of information from EO data for services in the food security sector mainly in Europe & Africa, allowing both access to EO data and processing of these data sets. Thereby it will foster smart, data-intensive agricultural and aquacultural applications in the scientific, private and public domain. The FS-TEP builds on a large and heterogeneous user community, spanning from application developers in agriculture to aquaculture, from small-scale farmers to agricultural industry, from public science to the finance and insurance sectors, from local and national administration to international agencies. To meet the requirements of these groups, the FS-TEP will provide different frontend interfaces. Service pilots will demonstrate the platform's ability to support agriculture and aquaculture with tailored EO based information services.The project team developing the FS-TEP and implementing pilot services during a 30 months period (started in April 2017) is led by Vista GmbH, Germany, supported by CGI Italy, VITO, Belgium, and Hatfield Consultants, Canada. It is funded by ESA under contract number 4000120074/17/I-EF.

  5. Tromboembolismo pulmonar e anticonceptivos orais – a propósito de um caso clínico.

    Directory of Open Access Journals (Sweden)

    Fernando Matos

    1996-05-01

    Full Text Available RESUMO: A propósito de um caso de Tromboembolismo Pulmonar (TEP, em mulher jovem a fazer anticonceptivo oral (ACO, os AA fazem uma revisão sumária dos ACO como factor de risco no TEP. SUMMARY: In reference to a clinical case of Pulmonary Thromboembolism (PTE in a young woman taking oral contraceptives (OC, the authors review the role of OC as a risk factor in PTE. Palavras-chave: Contracepção oral, Tromboembolismo pulmonar, Factores de risco vascular, Key-words: Oral contraception, Pulmonary embolism, Vascular risk factors

  6. ANALISIS COSTE-EFECTIVIDAD DE DISTINTOS MÉTODOS DE DIAGNÓSTICO POR IMAGEN DEL TROMBOEMBOLISMO PULMONAR AGUDO

    Directory of Open Access Journals (Sweden)

    Stella Maris Batallés

    2009-01-01

    Full Text Available La técnica diagnóstica óptima para detectar tromboembolismo pulmonar agudo (TEP continúa en discusión. La gammagrafía pulmonar de ventilación/perfusión ha sido el examen preferido durante décadas, pero con el advenimiento de nuevas pruebas de imágenes las posibilidades diagnósticas se ampliaron, siendo necesario evaluarlas desde la perspectiva del coste y de la efectividad. El objetivo de este trabajo fue evaluar distintos métodos de diagnóstico por imagen para detectar TEP agudo para determinar el más coste-efectivo. Métodos. Análisis de coste-efectividad (CE empleando un árbol de decisiones para modelar distintas pruebas (centellograma V/Q, TC helicoidal, angiografía por tomografía computada multidetector (TCMD, resonancia magnética por imágenes (RMI y arteriografía convencional. Se obtuvieron valores de sensibilidad, especificidad, valor predictivo positivo (VPP y negativo (VPN de las pruebas diagnósticas. Resultado medido: "caso detectado de TEP". Los costes evaluados fueron los directos, expresados en euros (t, incluyendo los secundarios a las complicaciones de los métodos diagnósticos. Se realizó un análisis de sensibilidad de una vía para evaluar la robustez de las conclusiones. Resultados. No se eliminaron pruebas por dominancia extendida. La tasa cruda de CE para TCMD fue de 486 t por cada caso de TEP detectado. El coste marginal entre la TC helicoidal y el centellograma V/Q fue de 103 t para detectar 8 casos adicionales de TEP, mientras que el coste marginal entre la TCMD y la TC helicoidal fue de 229 t para detectar un caso adicional de TEP. Conclusiones. La prueba diagnóstica más coste-efectiva fue la TCMD, hallazgo que mostró robustez en el análisis de sensibilidad. Sin embargo, el análisis de C-E incremental nos mostró que la TCMD costó 229 t más respeto a la TC helicoidal para lograr una mínima mejora en la efectividad de la prueba (detección de TEP agudo. El alto valor predictivo negativo de

  7. Towards the Rosetta Stone of planet formation

    Directory of Open Access Journals (Sweden)

    Schmidt T.O.B.

    2011-02-01

    Full Text Available Transiting exoplanets (TEPs observed just ~10 Myrs after formation of their host systems may serve as the Rosetta Stone for planet formation theories. They would give strong constraints on several aspects of planet formation, e.g. time-scales (planet formation would then be possible within 10 Myrs, the radius of the planet could indicate whether planets form by gravitational collapse (being larger when young or accretion growth (being smaller when young. We present a survey, the main goal of which is to find and then characterise TEPs in very young open clusters.

  8. Tracers development for the PET study of nicotinic receptors: [{sup 11}C]-mecamylamine and [{sup 11}C]-SIB 1553A. Tritium and carbon-11 radiolabelling of a serine proteinase inhibitor: the t-PA{sub stop}; Developpement de traceurs pour l'etude des recepteurs nicotiniques par TEP: la [{sup 11}C]-mecamylamine et le [{sup 11}C]SIB 1553A. Radiomarquages par le tritium et le carbone-11 d'un inhibiteur d'une serine protease: le t-PA{sub stop}

    Energy Technology Data Exchange (ETDEWEB)

    Sobrio, F.

    2002-12-15

    In order to develop radiotracers for the Positron Emission Tomography (PET), we labelled both the mecamylamine and SIB-1553A with carbon-11 to study the nicotinic cholinergic receptors (nAChRs). The radiosynthesis of [{sup 11}C]-t-PA{sub stop} and the labelling with tritium of one analogue were realized for cerebral ischemia PET studies. The [{sup 11}C]-mecamylamine, a non-competitive and non-selective nAChRs antagonist was synthesized in 45 min via a N-[{sup 11}C]-methylation reaction. In the rat brain, the ex vivo studies showed no radio-metabolite 45 min after the injection of [{sup 11}C]-mecamylamine. The uptake kinetics in the rat brain or in vivo by PET in the anesthetized baboon or in the conscious monkey, reached a plateau around 45-50 min after injection. However, the saturation or displacement experiments did not permit to exhibit nor a significant difference of labelling between the different cerebral regions nor a specific uptake. In consequence, the [{sup 11}C]-mecamylamine was not an appropriate radioligand for nAChRs PET study. The labelling of [{sup 11}C]-SIB 1553A, a selective agonist for the nicotinic {beta}4 subunit, required the synthesis in 5 steps (56% overall yield) of precursor for the incorporation of carbon-11. The radiosynthesis was performed in 36 min by a N-[{sup 11}C]-methylation reaction (yield: 75%). The [{sup 11}C]-t-PA{sub stop} was obtained from [{sup 11}C]-KCN with yields from 80 to 90%. For the first time with carbon-11, the formation of an amidine group was realized from a nitrile group. The labelling by isotopic exchange of hydrogen by tritium of the t-PA{sub stop} did not permit to obtain the [{sup 3}H]-t-PA{sub stop} but a tritiated analogue. This compound will be used to study its vectorization by micro-encapsulation. (author)

  9. Speech Rehabilitation For 10 Alaryngeal Patients Using Tracheoesophageal Puncture And Prosthesis Insertion In Amir Alam And Imam Khomeini Hospitals 2002-2003

    Directory of Open Access Journals (Sweden)

    M.T. Khorsi Ashtiani

    2006-05-01

    Full Text Available Background and Aim: Total laryngectomy following laryngeal cancer has many sequelae , that loss of voice is the most important of them. Tracheoesophageal puncture (TEP and prosthesis insertion has evolved into the most widely used and accepted technique for vocal rehabilitation. Materials and Methods: 10 patients that underwent TEP in Amir Alam and Imam Khomeini hospitals from Feb. 2002 through Nov. 2003; were included in this study. Prosthesis insertion in 4 patients is primary and in 6 patients is secondary; and all patients are men. Results: The age of patients was between 50 to 70. 90% of patients had history of cigarette smoking and 10% of them had history of drinking alcohol. Salivary leakage was seen in 30% of patients that was improved with conservative management. Fluency of speech in 30% of patients and intelligibility of speech & voice quality in 40% of patients is good. Conclusion: We could conclude that TEP has less complication & better speech results of other vocal rehabilitation methods. Carefully selection of patients & size of prosthesis has important role in results of TEP.

  10. Mechanical Performance Evaluation of a Top End Piece for Dual Cooled Fuels

    International Nuclear Information System (INIS)

    Kim, Jae Yong; Yoon, Kyung Ho; Kim, Hyung Kyu; Choi, Woo Seok

    2011-01-01

    A fuel assembly consists of five major components, i.e., a top end piece (TEP), a bottom end piece (BEP), spacer grids (SGs), guide tubes (GTs) and an instrumentation tube (IT): in addition, it also includes fuel rods (FRs). The TEP/BEP should satisfy stress intensity limits according to the conditions A and B of ASME, Section III, Division 1.Subsection NB. In a dual-cooled fuel assembly, the array and position of fuel rods are different from those in a conventional PWR fuel assembly; these changes are necessary for achieving power uprating. The flow plates of the TEP and BEP have to be modified accordingly. The pattern and shape of the flow holes were newly designed. To verify the strength compatibility, the Tresca stress limit according to the ASME code was investigated in the case of an axial load of 22.241 kN. In this paper, the stress linearization procedure for strength evaluation of a newly designed TEP is presented

  11. Stress Linearization and Strength Evaluation of the BEP's Flow Plates for a Dual Cooled Fuel Assembly

    International Nuclear Information System (INIS)

    Kim, Jae Yong; Yoon, Kyung Ho; Kang, Heung Seok; Lee, Young Ho; Lee, Kang Hee; Kim, Hyung Kyu

    2009-01-01

    A fuel assembly is composed of 5 major components, such as a top end piece (TEP), a bottom end piece (BEP), spacer grids (SGs), guide tubes (GTs) and an instrumentation tube (IT) and fuel rods (FRs). There are no ASME criteria about all components except for a TEP/BEP. The TEP/BEP should satisfy stress intensity limits in case of condition A and B of ASME, Section III, Division 1 . Subsection NB. In a dual cooled fuel assembly, the array and position of fuels are changed from those of a conventional PWR fuel assembly to achieve a power uprating. The flow plates of top/bottom end pieces (TEP/BEP) have to be modified into proper shape to provide flow holes to direct the heated coolant into/out of the fuel assembly but structural intensity of these plates within a 22.241 kN axial loading should satisfy Tresca stress limits in ASME code. In this paper, stress linearization procedure and strength evaluation of a newly designed BEP for the dual cooled fuel assembly are described

  12. Developing alternative indices of reproductive potential for use in fisheries management : Case studies for stocks spanning an information gradient

    DEFF Research Database (Denmark)

    Marshall, C.T.; O'Brien, L.; Tomkiewicz, Jonna

    2003-01-01

    sufficient data to reconstruct a time series of total eggproduction (TEP), whereas, the remaining stocks were limited to estimating proxies for stockreproductive potential. For some of the case studies the alternative indices explained a higheramount of recruitment variation than did SSB. Other case studies...

  13. Situating ICT in the Teacher Education Program: Overcoming Challenges, Fulfilling Expectations

    Science.gov (United States)

    Martinovic, Dragana; Zhang, Zuochen

    2012-01-01

    This exploratory case study examined pre-service teachers' expectations of and attitudes toward the learning and integrating of ICT into their teaching, and their perceptions of the availability and use of ICT in the Teacher Education Program (TEP) and their placement schools. For two years in a row the researchers collected data through online…

  14. VALUE OF THROMBOEMBOLIC PROPHYLAXIS IN PREVENTION OF THE THROMBOEMBOLISM IN ORTHOPEDIC SURGERY AND TRAUMATOLOGY

    Directory of Open Access Journals (Sweden)

    Gorana Rancic

    2006-07-01

    Full Text Available In the period between March 1, 2003 to June 1, 2003 at the Clinic of Orthopaedic Surgery and Traumatology, we treated 174 patients with injured or diseased extremities. An average age was 46,95 years (27-81. We treated 33 patients (18,9% nonoperatively and 141 patients (81,1% operatively. Preoperative and postoperative thromboembolic profilaxis (TEP with low molecular heparin was registered in 50 patients (28,9%. In the first 10 days, 12 (9,2% patients without TEP had signs of thromboembolism, 2 patients died in the first 10 days with the signs of thromboembolism.In the control group, in the period between March 1, 2005 to June 1, 2005 at the Clinic of Orthopaedic Surgery and Traumatology, we treated 162 patients with injured or diseased extremities. The average age was 47,2 years (17-82. We treated 29 patients nonoperatively (17,9% and 133 patients (82,1% operatively. All patients had preoperative and postoperative thromboembolic profilaxis (TEP with low molecular heparin. In the first 10 days, 5 (3% patients had signs of thromboembolism. None of the patients from control group died.Our results showed that TEP in orthopaedic surgery and traumatology is necessary.

  15. Pre-Service Bilingual Teachers and Their Invisible Scars: Implications for Preparation Programs

    Science.gov (United States)

    Sarmiento-Arribalzaga, Matilde A.; Murillo, Luz A.

    2010-01-01

    In this paper, we describe how language "autobiographies" are used in a teacher preparation program (TEP) as a healing pedagogy to understand the impact longstanding traditions of symbolic violence in education have had on Latino students who are in the process of becoming teachers. Writing about themselves and their education experience…

  16. 78 FR 74825 - Medicare and Medicaid Programs: Hospital Outpatient Prospective Payment and Ambulatory Surgical...

    Science.gov (United States)

    2013-12-10

    ... Radiosurgery TEP Technical Expert Panel TMS Transcranial Magnetic Stimulation Therapy TOPs Transitional... Determination and Subsequent Years f. Data Submission Requirements for Measure Data Submitted via Web-Based Tool... Online Data Submission Tool a. Background for the CY 2015 Payment Determination and Subsequent Years b...

  17. 78 FR 43533 - Medicare and Medicaid Programs: Hospital Outpatient Prospective Payment and Ambulatory Surgical...

    Science.gov (United States)

    2013-07-19

    ... Skilled Nursing Facility SRS Stereotactic Radiosurgery TEP Technical Expert Panel TMS Transcranial...-Based Tool for the CY 2016 Payment Determination and Subsequent Years g. Proposed Data Submission... and Subsequent Years 5. Proposed Requirements for Data Submitted Via a CMS Online Data Submission Tool...

  18. Changes in feedwater organic matter concentrations based on intake type and pretreatment processes at SWRO facilities, Red Sea, Saudi Arabia

    KAUST Repository

    Dehwah, Abdullah

    2015-03-01

    Transparent exopolymer particles (TEP), natural organic matter, and bacterial concentrations in feedwater are important factors that can lead to membrane biofouling in seawater reverse osmosis (SWRO) systems. Two methods for controlling these concentrations in the feedwater prior to pretreatment have been suggested; use of subsurface intake systems or placement of the intake at a greater depth in the sea. These proposed solutions were tested at two SWRO facilities located along the Red Sea of Saudi Arabia. A shallow well intake system was very effective in reducing the algae and bacterial concentrations and somewhat effective in reducing TEP concentrations. An intake placed at a depth of 9. m below the surface was found to have limited impact on improving water quality compared to a surface intake. The algae and bacteria concentration in the feedwater (deep) was lower compared to the surface seawater, but the overall TEP concentration was higher. Bacteria and TEP measurements made in the pretreatment process train in the plant and after the cartridge filters suggest that regrowth of bacteria is occurring within the cartridge filters.

  19. Organic carbon movement through two SWRO facilities from source water to pretreatment to product with relevance to membrane biofouling

    KAUST Repository

    Alshahri, Abdullah Hassan Mohammed

    2016-12-29

    The presence of algae, bacteria, various fractions of natural organic matter (NOM), and transparent exopolymer particles (TEP) in the raw water, after each pretreatment process and in the permeate and concentrate streams, were measured at two SWRO plants to assess biofouling potential. It was found that the most significant process controlling the concentration of algae, bacteria, and the biopolymer and humic substances was the intake type with the subsurface intake discharge showing significant reductions. The mixed media filtration process was marginally useful in removing some TOC and NOM, but had little effect on TEP removal. Some bacterial regrowth may be occurring in the cartridge filters, but the evidence is inconsistent. Significant quantities of the biopolymer and humic substance concentrations were found to be retained in the membranes, but the concentrations were significantly greater in the facility using an open-ocean intake. Bacteria and TEP were found in the permeate stream, which may document bacterial regrowth and TEP production downstream of the membrane process. Measurements of the organic carbon passage through SWRO facilities can be successfully used to evaluate pretreatment process effectiveness and to make SWRO plant operational improvements.

  20. Magnetoelectric effect in cobalt ferrite–barium titanate composites ...

    Indian Academy of Sciences (India)

    relaxation process and resistivity of the materials. However, the conductivity behavior in. CoFe2O4–BaTiO3 composites has not been studied. In this paper we report the dc electrical conductivity and thermoelectric power (TEP) as a function of temperature for this system. Dielectric behavior is also studied to understand the ...

  1. Test and Evaluation Plan for Waste Feed Delivery Project W-521

    Energy Technology Data Exchange (ETDEWEB)

    MAY, T.H.

    2000-09-11

    The purpose of this Test and Evaluation Plan (TEP) is to identify the Test and Evaluation (T&E) activities required to confirm that design and installation of systems, structures, and components (SSCs) provided by Project W-521 will satisfy Level 2 and operational requirements, and to describe the T&E program to be implemented during the various project phases. This TEP establishes a sequence of test and evaluation activities to provide confidence that all required T&E activities will be accomplished successfully to support a smooth and timely turnover of completed SSCs to the River Protection Project (RPP) operations organization. In addition, organizational responsibilities for managing and performing the T&E activities are outlined. This TEP was prepared in accordance with the guidance and requirements of the RPP Test and Evaluation Management Plan. The Project W-521 TEP documents the process that will show that the SSCs are (1) compliant with the requirements of the Level 2 Specifications, (2) constructed in accordance with approved design drawings and procurement/construction specifications, (3) installed properly and appropriately integrated into the existing systems, and (4) will operate adequately on turnover to the customer.

  2. A meta-analysis of surgical morbidity and recurrence after laparoscopic and open repair of primary unilateral inguinal hernia.

    LENUS (Irish Health Repository)

    O'Reilly, Elma A

    2012-05-01

    Laparoscopic inguinal hernia repair (LIHR), using a transabdominal preperitoneal (TAPP) or totally extraperitoneal (TEP) technique, is an alternative to conventional open inguinal hernia repair (OIHR). A consensus on outcomes of LIHR when compared with OIHR for primary, unilateral, inguinal hernia has not been reached.

  3. Application of PM-IRRAS to study thin films on industrial and environmental samples.

    Science.gov (United States)

    Kycia, Annia H; Koczkur, Kallum; Leitch, J Jay; Lipkowski, Jacek; Zamlynny, Vlad; Petryk, Michael W P

    2013-02-01

    Polarization modulation-infrared reflection absorption spectroscopy (PM-IRRAS) was employed to analyze two unique samples: (1) an industrially prepared alkoxysilane-pretreated aluminum alloy (AA6111) in the absence and presence of a ~600-nm-thick lubricant coating and (2) a chemical warfare agent simulant, triethyl phosphate (TEP), on glass. For the pretreated aluminum samples, PM-IRRAS spectra were analyzed for three distinct regions; the SiO stretching vibration around 1120 cm(-1), the NH(2) bending mode at ~1600 cm(-1) and the CH stretching region around 2900 cm(-1). Our results showed that increasing the curing temperature (from 55 to 100 °C) improved the overall extent of cross-linking within the siloxane network. In addition, the spectra of lubricant (top coating) and the underlying siloxane layer for the aluminum samples with lubricant were collected for the same sample. Our results show that the nature of the siloxane film remains intact and unaltered after deposition of the lubricant top-coat. For detection of TEP on glass, the band at 1268 cm(-1), corresponding to the P═O vibration, was monitored. A droplet of TEP solution in dichloromethane was deposited on glass. After solvent evaporation had occurred, the intensity of the P═O vibration band was used to construct calibration curves to determine the experimental limit of detection, which was found to be ~200 μg for TEP on glass.

  4. Alcian blue-stained particles in a eutrophic lake

    DEFF Research Database (Denmark)

    Worm, J.; Søndergaard, Morten

    1998-01-01

    We used a neutral solution of Alcian Blue to stain transparent particles in eutrophic Lake Frederiksborg Slotss0, Denmark. Alcian Blue-stained particles (ABSP) appeared to be similar to the so-called transparent exopolymer particles (TEP) identified with an acidic solution of Alcian Blue. Our...

  5. Abundance and relationship of bacteria with transparent exopolymer ...

    Indian Academy of Sciences (India)

    Smith et al 1995) have been demonstrated to be of great significance in the biogeochemistry of the marine regimes (Alldredge et al 1993; Kumar et al 1998). In the light of this recent discovery, we quantified TEP during the summer monsoon of 1996 for the first time from the Arabian Sea with an aim to understand its.

  6. 77 FR 57564 - Combined Notice of Filings #1

    Science.gov (United States)

    2012-09-18

    ...-3876-006; ER11-2044-007; ER10- 2611-004. Applicants: Bishop Hill Energy II LLC. Description: Notice of Change in Status of Bishop Hill Energy II LLC, et al. Filed Date: 9/10/12. Accession Number: 20120910...: Tucson Electric Power Company. Description: TEP SRSG Agreement-Addition of Star West to be effective 5/17...

  7. Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets

    NARCIS (Netherlands)

    Best, Myron G.; Sol, Nik; In ‘t Veld, Sjors G.J.G.; Vancura, Adrienne; Muller, Mirte; Niemeijer, Anna Larissa N.; Fejes, Aniko V.; Tjon Kon Fat, Lee Ann; Huis in 't Veld, Anna E; Leurs, Cyra; Le Large, Tessa Y.; Meijer, Laura L.; Kooi, Irsan E.; Rustenburg, François; Schellen, Pepijn; Verschueren, Heleen; Post, Edward; Wedekind, Laurine E.; Bracht, Jillian; Esenkbrink, Michelle; Wils, Leon; Favaro, Francesca; Schoonhoven, Jilian D.; Tannous, Jihane; Meijers-Heijboer, Hanne; Kazemier, Geert; Giovannetti, Elisa; Reijneveld, Jaap C.; Idema, Sander; Killestein, Joep; Heger, Michal; de Jager, Saskia C.; Urbanus, Rolf T.; Hoefer, Imo E.; Pasterkamp, Gerard; Mannhalter, Christine; Gomez-Arroyo, Jose; Bogaard, Harm-Jan; Noske, David P.; Vandertop, W. Peter; van den Broek, Daan; Ylstra, Bauke; Nilsson, R. Jonas A; Wesseling, Pieter; Karachaliou, Niki; Rosell, Rafael; Lee-Lewandrowski, Elizabeth; Lewandrowski, Kent B.; Tannous, Bakhos A.; de Langen, Adrianus J.; Smit, Egbert F.; van den Heuvel, Michel M; Wurdinger, Thomas

    2017-01-01

    Blood-based liquid biopsies, including tumor-educated blood platelets (TEPs), have emerged as promising biomarker sources for non-invasive detection of cancer. Here we demonstrate that particle-swarm optimization (PSO)-enhanced algorithms enable efficient selection of RNA biomarker panels from

  8. [Patients' intervention in a therapeutic education program dedicated to systemic lupus: definitions, setting and benefits].

    Science.gov (United States)

    Hervier, B; Magar, Y; Allab, F; Richard, K; Neves, Y; Danjou, S; Amoura, Z; Ayçaguer, S

    2015-10-01

    Though recommended, participation of patients with specific expertise in therapeutic education programs (TEP) is rare. This work reports the experience of a national reference centre for rare systemic diseases. Involvement of "expert patients" (EP) has been planned from the development of a TEP dedicated to systemic lupus: patients' roles and required expertise have been defined and linked to the pedagogical tools. Such patients have been recruited during individual interviews and called to participate to specific pedagogical training. EP intervention have been evaluated by questionnaire to EP and health care providers. Three EP's functions have been identified: sharing experiences, giving "tips and tricks" and promoting dialogue. EP's interventions has been organised into a hierarchy (from sharing to co-animation). Among 298 patients enrolled in the TEP, 25 (8.4%) have been identified as possible EP. Eight of them (32%) benefited from a specific training of 12 hours. Among these patients, two (25%) regularly participate to the education sessions. For EP as well as for health care providers, EP's intervention seems beneficial (visual scale scores of 7.5 and 9.5, respectively). Though difficult to organise, EP's intervention in TEP dedicated to rare systemic diseases seems useful and would earn to be increase. Copyright © 2015 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

  9. Construction and evaluation of a novel triple cell epitopebased ...

    African Journals Online (AJOL)

    Purpose: To construct a novel triple cell epitope-based polypeptide vaccine against cow mastitis induced by Staphylococcus aureus, Escherichia coli and Streptococcus and to reduce the use of antibiotics. Methods: Based on bioinformatics approach, a novel triple epitope-based polypeptide (CM-TEP) was designed and ...

  10. 78 FR 72891 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Public...

    Science.gov (United States)

    2013-12-04

    ... consumer attitudes, knowledge, and experiences with long-term care, how people plan for the risk of needing... asks questions on (1) the risk of needing long- term care; (2) psychological characteristics, knowledge..., medical conditions, and income and assets have been extensively vetted with ASPE, the TEP, other experts...

  11. X-ray photoelectron spectroscopy study and thermoelectric properties of Al-doped ZnO thin films

    International Nuclear Information System (INIS)

    Li Li; Fang Liang; Zhou Xianju; Liu Ziyi; Zhao Liang; Jiang Sha

    2009-01-01

    In this paper, high quality Al-doped ZnO (AZO) thin films were prepared by direct current (DC) reactive magnetron sputtering using a Zn target (99.99%) containing Al of 1.5 wt.%. The films obtained were characterized by X-ray photoelectron spectroscopy (XPS) and thermoelectric measurements. The XPS results reveal that Zn and Al exist only in oxidized state, while there are dominant crystal lattice and rare adsorbed oxygen for O in the annealed AZO thin films. The studies of thermoelectric property show a striking thermoelectric effect in the AZO thin films. On the one hand, the thermoelectromotive and magnetothermoelectromotive forces increase linearly with increasing temperature difference (ΔT). On the other hand, the thermoelectric power (TEP) decreases with the electrical resistance of the sample. But the TEP increases with the increase of temperature below 300 K, and it nearly does not change around room temperature. The experimental results also demonstrate that the annealing treatment increases TEP, while the external magnetic field degrades TEP.

  12. Abdulla Fayez Modeling of groundwater flow for Mujib aquifer ...

    Indian Academy of Sciences (India)

    Carbon and oxygen isotope compositions of the carbonate facies in the Vindhyan Supergroup, central India. 113. Banerjee Santanu see Sarkar Subir. 49 see Dutta Suryendu. 99. Barnes J see Shalini A. 451. Bhaskar P V. Dynamics of transparent exopolymeric particles. (TEP) and particle-associated carbohydrates in the.

  13. Journal of Earth System Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Dynamics of transparent exopolymeric particles (TEP) and particle-associated carbohydrates in the Dona Paula bay, west coast of India · P V Bhaskar Narayan B Bhosle ... and feedbacks. The influence of Indian Ocean Dipole (IOD) on biogeochemistry of carbon in the Arabian Sea during 1997–1998 · V V S S Sarma.

  14. Distinguishing the Influences of Father's and Mother's Involvement on Adolescent Academic Achievement: Analyses of Taiwan Education Panel Survey Data

    Science.gov (United States)

    Hsu, Hsien-Yuan; Zhang, Dalun; Kwok, Oi-Man; Li, Yan; Ju, Song

    2011-01-01

    Using a sample drawn from Taiwan, this study evaluated the role of mother and father involvement in adolescent academic achievement. The participants were drawn from the Taiwan Education Panel Survey (TEPS) and consisted of 8,108 adolescents who studied seventh grade in 2001. Father and mother involvement related to academic achievement was…

  15. Comment on Turbulent Equipartition Theory of Toroidal Momentum Pinch

    International Nuclear Information System (INIS)

    Hahm, T.S.; Diamond, P.H.; Gurcan, O.D.; Rewoldt, G.

    2009-01-01

    This response demonstrates that the comment by Peeters et al. contains an incorrect and misleading interpretation of our paper (Hahm et al., Phys. Plasmas 15, 055902 (2008)) regarding the density gradient dependence of momentum pinch and the turbulent equipartition (TEP) theory

  16. Journal of Earth System Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Earth System Science. P V Bhaskar. Articles written in Journal of Earth System Science. Volume 115 Issue 4 August 2006 pp 403-413. Dynamics of transparent exopolymeric particles (TEP) and particle-associated carbohydrates in the Dona Paula bay, west coast of India · P V Bhaskar Narayan B ...

  17. Journal of Earth System Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Rapid cycling of these compounds indicates their importance in the cycling of nitrogen in marine waters. Volume 115 Issue 4 August 2006 pp 403-413. Dynamics of transparent exopolymeric particles (TEP) and particle-associated carbohydrates in the Dona Paula bay, west coast of India · P V Bhaskar Narayan B Bhosle.

  18. Quorum-sensing regulator RhlR but not its autoinducer RhlI enables Pseudomonas to evade opsonization.

    Science.gov (United States)

    Haller, Samantha; Franchet, Adrien; Hakkim, Abdul; Chen, Jing; Drenkard, Eliana; Yu, Shen; Schirmeier, Stefanie; Li, Zi; Martins, Nelson; Ausubel, Frederick M; Liégeois, Samuel; Ferrandon, Dominique

    2018-03-09

    When Drosophila melanogaster feeds on Pseudomonas aeruginosa , some bacteria cross the intestinal barrier and eventually proliferate in the hemocoel. This process is limited by hemocytes through phagocytosis. P. aeruginosa requires the quorum-sensing regulator RhlR to elude the cellular immune response of the fly. RhlI synthesizes the autoinducer signal that activates RhlR. Here, we show that rhlI mutants are unexpectedly more virulent than rhlR mutants, both in fly and in nematode intestinal infection models, suggesting that RhlR has RhlI-independent functions. We also report that RhlR protects P. aeruginosa from opsonization mediated by the Drosophila thioester-containing protein 4 (Tep4). RhlR mutant bacteria show higher levels of Tep4- mediated opsonization, as compared to rhlI mutants, which prevents lethal bacteremia in the Drosophila hemocoel. In contrast, in a septic model of infection, in which bacteria are introduced directly into the hemocoel, Tep4 mutant flies are more resistant to wild-type P. aeruginosa, but not to the rhlR mutant. Thus, depending on the infection route, the Tep4 opsonin can either be protective or detrimental to host defense. © 2018 The Authors.

  19. GENDER PARTICIPATION IN TECHNICAL TRAINING INSTITUTIONS

    African Journals Online (AJOL)

    Informal interviews and questionnaires were used to collect data that were analysed within the framework of human capital theory. Sex balance was lacking in TEP and most institutions were internally inefficient, with endogenous factors forcing trainees out of the training programmes. Eastern Africa Social Science Research ...

  20. 154. ¿Es útil el sistema de asistencia oxigenador de membrana extracorpórea en el tromboembolismo pulmonar masivo?

    Directory of Open Access Journals (Sweden)

    J.A. Sarralde

    2012-04-01

    Conclusión: El sistema ECMO venoarterial es muy útil en pacientes con TEP, ya que realiza dos funciones: descargar el corazón derecho y oxigenar al paciente. Podemos heparinizar al paciente para revertir el cuadro, ya que las incisiones a nivel femoral son fácilmente controladas.

  1. The Effect of Telephone Support Groups on Costs of Care for Veterans with Dementia

    Science.gov (United States)

    Wray, Laura O.; Shulan, Mollie D.; Toseland, Ronald W.; Freeman, Kurt E.; Vasquez, Bob Edward; Gao, Jian

    2010-01-01

    Purpose: Few studies have addressed the effects of caregiver interventions on the costs of care for the care recipient. This study evaluated the effects of a caregiver education and support group delivered via the telephone on care recipient health care utilization and cost. Design and Methods: The Telehealth Education Program (TEP) is a…

  2. Energy-Exchange Project

    Energy Technology Data Exchange (ETDEWEB)

    1982-04-01

    The purpose of the study was to determine what energy savings can be achieved by coordinating the resources and requirements of two facilities, the 26th Ward Water Pollution Control Plant (WPCP) and a housing development named Starrett City with its own total energy system. It was determined that three energy exchange options were economically and technically feasible. These include: the transfer of digester gas produced at the 26th Ward to the boilers at the Starrett City's total energy plant (TEP); the transfer of hot water heated at the TEP to the 26th Ward for space and process heating; and the transfer of coal effluent waste water from the 26th Ward to the condenser cooling systems at the TEP. Technical information is presented to support the findings. The report addresses those tasks of the statement of work dedicated to data acquisition, analysis, and energy conservation strategies internal to the Starrett City TEP and the community it supplies as well as to the 26th Ward WPCP. (MCW)

  3. Study of the effect of oxygen for the recovery and recrystallization of zirconium; Etude de l'effet de l'oxygene sur la restauration et la recristallisation du zirconium

    Energy Technology Data Exchange (ETDEWEB)

    Benbouta, R.; Mihi, A.; Abbassi, A.; Brioua, M.; Adami, L. [Batna Univ., Lab. de Corrosion, Dept. de Mecanique, Faculte des Sciences de l' Ingenieur (Algeria)

    2009-09-15

    The effect of oxygen for the recovery and recrystallization of commercial zirconium and pure zirconium (Van-Arkel) was studied. The method of thermoelectric power T.E.P. was used. The obtained results showed that an increase in oxygen content of the solid solution has for effect to slow down the recovery and recrystallization kinetics and to reduce their amplitude (authors)

  4. The Urban Exploitation Platform - An instrument for the global provision of indicators related to sustainable cities and communities

    Science.gov (United States)

    Esch, Thomas; Asamer, Hubert; Hirner, Andreas; Marconcini, Mattia; Metz, Annekatrin; Uereyen, Soner; Zeidler, Julian; Boettcher, Martin; Permana, Hans; Boissier, Enguerran; Mathot, Emmanuel; Soukop, Tomas; Balhar, Jakub; Svaton, Vaclav; Kuchar, Stepan

    2017-04-01

    The Sentinel fleet will provide a so-far unique coverage with Earth Observation (EO) data and therewith new opportunities for the implementation of methodologies to generate innovative geo-information products and services supporting the SDG targets. It is here where the TEP Urban project is supposed to initiate a step change by providing an open and participatory platform that allows any interested user to easily exploit large-volume EO data pools, in particular those of the European Sentinel and the US Landsat missions, and derive thematic geo-information, metrics and indicators related to the status and development of the built environment. Key component of TEP Urban initiative is the implementation of a web-based platform (https://urban-tep.eo.esa.int) employing distributed high-level computing infrastructures and providing key functionalities for i) high-performance access to satellite imagery and other data sources such as statistics or topographic data, ii) state-of-the-art pre-processing, analysis, and visualization techniques, iii) customized development and dissemination of algorithms, products and services, and iv) networking and communication. This contribution introduces the main facts about the TEP Urban platform, including a description of the general objectives, the platform systems design and functionalities, and the available portfolio of products and services that can directly serve the global provision of indicators for SDG targets, in particular related to SDG 11.

  5. Author Details

    African Journals Online (AJOL)

    Nabil, Chikhaoui. Vol 23, No 1 (2016) - Articles Carcinome cutané de Merkel: apport de la TEP-TDM au18FDG. Abstract PDF. ISSN: 1937-8688. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use ...

  6. Transatlantic Regulatory Cooperation: Background and Analysis

    Science.gov (United States)

    2009-08-24

    regulatory cooperation must deal with a number of key differences between the United States and EU concerning approaches to regulation. Key differences bear ...U.S. companies.51 2. Irrespective of annual summits, the TEP, by some accounts, went into hibernation from 1998 to 2004. Despite the many

  7. The Effect of Lamotrigine and Levetiracetam on TMS-Evoked EEG Responses Depends on Stimulation Intensity

    Directory of Open Access Journals (Sweden)

    Isabella Premoli

    2017-10-01

    Full Text Available The combination of transcranial magnetic stimulation and electroencephalography (TMS-EEG has uncovered underlying mechanisms of two anti-epileptic medications: levetiracetam and lamotrigine. Despite their different mechanism of action, both drugs modulated TMS-evoked EEG potentials (TEPs in a similar way. Since both medications increase resting motor threshold (RMT, the current aim was to examine the similarities and differences in post-drug TEPs, depending on whether stimulation intensity was adjusted to take account of post-drug RMT increase. The experiment followed a placebo controlled, double blind, crossover design, involving a single dose of either lamotrigine or levetiracetam. When a drug-induced increase of RMT occurred, post-drug measurements involved two blocks of stimulations, using unadjusted and adjusted stimulation intensity. A cluster based permutation analysis of differences in TEP amplitude between adjusted and unadjusted stimulation intensity showed that lamotrigine induced a stronger modulation of the N45 TEP component compared to levetiracetam. Results highlight the impact of adjusting stimulation intensity.

  8. Effects of transparent exopolymer particles and suspended particles on the survival of Salmonella enterica serovar Typhimurium in seawater.

    Science.gov (United States)

    Davidson, Marion C F; Berardi, Terra; Aguilar, Beatriz; Byrne, Barbara A; Shapiro, Karen

    2015-03-01

    The bacterium Salmonella enterica can infect marine mammals and has been increasingly implicated in seafood-borne disease outbreaks in humans. Despite the risk this zoonotic agent poses to animals and people, little is known regarding the environmental factors that affect its persistence in the sea. The goal of this study was to evaluate the impact of two constituents on the survival of Salmonella in the marine environment: transparent exopolymer particles (TEP) and suspended particles. A decay experiment was conducted by spiking Salmonella into bottles containing seawater, seawater with alginic acid as a source of TEP, filtered seawater or filtered seawater with alginic acid. Survival of Salmonella was monitored using culture followed by enrichment assays to evaluate if the bacteria entered a viable but non-cultivable (VBNC) state. Salmonella cell counts dropped significantly faster (P ≤ 0.05) in the unfiltered seawater samples with and without TEP. The slowest decay occurred in filtered seawater containing alginic acid, with VBNC Salmonella persisting for 17 months. These findings suggest that TEP may favor Salmonella survival while suspended particles facilitate its decay. Insight on the survival of allochthonous, zoonotic pathogens in seawater can guide monitoring, management and policy decisions relevant to wildlife and human public health. © FEMS 2015. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  9. Journal of Earth System Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Surface seawater samples were collected over a period of 27 months at a shallow water station in Dona Paula bay from 1998-2000.The samples were analyzed to assess the seasonal variations, inter-annual variability and the contributions of: transparent exopolymeric particles (TEP)concentration,; two forms of ...

  10. Authoritarian Parenting and Asian Adolescent School Performance: Insights from the US and Taiwan

    Science.gov (United States)

    Pong, Suet-ling; Johnston, Jamie; Chen, Vivien

    2010-01-01

    Our study re-examines the relationship between parenting and school performance among Asian students. We use two sources of data: wave I of the Adolescent Health Longitudinal Survey (Add Health), and waves I and II of the Taiwan Educational Panel Survey (TEPS). Analysis using Add Health reveals that the Asian-American/European-American difference…

  11. Developpement d'algorithmes de reconstruction statistique appliques en tomographie rayons-X assistee par ordinateur

    Science.gov (United States)

    Thibaudeau, Christian

    La tomodensitometrie (TDM) permet d'obtenir, et ce de facon non invasive, une image tridimensionnelle de l'anatomie interne d'un sujet. Elle constitue l'evolution logique de la radiographie et permet l'observation d'un volume sous differents plans (sagittal, coronal, axial ou n'importe quel autre plan). La TDM peut avantageusement completer la tomographie d'emission par positrons (TEP), un outil de predilection utilise en recherche biomedicale et pour le diagnostic du cancer. La TEP fournit une information fonctionnelle, physiologique et metabolique, permettant la localisation et la quantification de radiotraceurs a l'interieur du corps humain. Cette derniere possede une sensibilite inegalee, mais peut neanmoins souffrir d'une faible resolution spatiale et d'un manque de repere anatomique selon le radiotraceur utilise. La combinaison, ou fusion, des images TEP et TDM permet d'obtenir cette localisation anatomique de la distribution du radiotraceur. L'image TDM represente une carte de l'attenuation subie par les rayons-X lors de leur passage a travers les tissus. Elle permet donc aussi d'ameliorer la quantification de l'image TEP en offrant la possibilite de corriger pour l'attenuation. L'image TDM s'obtient par la transformation de profils d'attenuation en une image cartesienne pouvant etre interpretee par l'humain. Si la qualite de cette image est fortement influencee par les performances de l'appareil, elle depend aussi grandement de la capacite de l'algorithme de reconstruction a obtenir une representation fidele du milieu image. Les techniques de reconstruction standards, basees sur la retroprojection filtree (FBP, filtered back-projection), reposent sur un modele mathematiquement parfait de la geometrie d'acquisition. Une alternative a cette methode etalon est appelee reconstruction statistique, ou iterative. Elle permet d'obtenir de meilleurs resultats en presence de bruit ou d'une quantite limitee d'information et peut virtuellement s'adapter a toutes formes

  12. Size-resolved characterization of the polysaccharidic and proteinaceous components of sea spray aerosol

    Science.gov (United States)

    Aller, Josephine Y.; Radway, JoAnn C.; Kilthau, Wendy P.; Bothe, Dylan W.; Wilson, Theodore W.; Vaillancourt, Robert D.; Quinn, Patricia K.; Coffman, Derek J.; Murray, Benjamin J.; Knopf, Daniel A.

    2017-04-01

    Dissolved organic polymers released by phytoplankton and bacteria abiologically self-assemble in surface ocean waters into nano-to micro-sized gels containing polysaccharides, proteins, lipids and other components. These gels concentrate in the sea surface microlayer (SML), where they can potentially contribute to sea spray aerosol (SSA). Sea spray is a major source of atmospheric aerosol mass over much of the earth's surface, and knowledge of its properties (including the amount and nature of the organic content), size distributions and fluxes are fundamental for determining its role in atmospheric chemistry and climate. Using a cascade impactor, we collected size-fractionated aerosol particles from ambient air and from freshly generated Sea Sweep SSA in the western North Atlantic Ocean together with biological and chemical characterization of subsurface and SML waters. Spectrophotometric methods were applied to quantify the polysaccharide-containing transparent exopolymer (TEP) and protein-containing Coomassie stainable material (CSM) in these particles and waters. This study demonstrates that both TEP and CSM in surface ocean waters are aerosolized with sea spray with the greatest total TEP associated with particles 5 000 nm. The higher concentrations of TEP and CSM in particles >5 000 nm most likely reflects collection of microorganism cells and/or fragments. The greater concentration of CSM in larger size particles may also reflect greater stability of proteinaceous gels compared to polysaccharide-rich gels in surface waters and the SML. Both TEP and CSM were measured in the ambient marine air sample with concentrations of 2.1 ± 0.16 μg xanthan gum equivalents (XG eq.) m-3 and 14 ± 1.0 μg bovine serum albumin equivalents (BSA eq.) m-3. TEP in Sea Sweep SSA averaged 4.7 ± 3.1 μg XG eq. m-3 and CSM 8.6 ± 7.3 μg BSA eq. m-3. This work shows the transport of marine biogenic material across the air-sea interface through primary particle emission and the

  13. A top-five list for emergency medicine: a pilot project to improve the value of emergency care.

    Science.gov (United States)

    Schuur, Jeremiah D; Carney, Dylan P; Lyn, Everett T; Raja, Ali S; Michael, John A; Ross, Nicholas G; Venkatesh, Arjun K

    2014-04-01

    IMPORTANCE The mean cost of medical care in the United States is growing at an unsustainable rate; from 2003 through 2011, the cost for an emergency department (ED) visit rose 240%, from $560 to $1354. The diagnostic tests, treatments, and hospitalizations that emergency clinicians order result in significant costs. OBJECTIVE To create a "top-five" list of tests, treatments, and disposition decisions that are of little value, are amenable to standardization, and are actionable by emergency medicine clinicians. DESIGN, SETTING, AND PARTICIPANTS Modified Delphi consensus process and survey of 283 emergency medicine clinicians (physicians, physician assistants, and nurse practitioners) from 6 EDs. INTERVENTION We assembled a technical expert panel (TEP) and conducted a modified Delphi process to identify a top-five list using a 4-step process. In phase 1, we generated a list of low-value clinical decisions from TEP brainstorming and e-mail solicitation of clinicians. In phase 2, the TEP ranked items on contribution to cost, benefit to patients, and actionability by clinicians. In phase 3, we surveyed all ordering clinicians from the 6 EDs regarding distinct aspects of each item. In phase 4, the TEP voted for a final top-five list based on survey results and discussion. MAIN OUTCOMES AND MEASURES A top-five list for emergency medicine. The TEP ranked items on contribution to cost, benefit to patients, and actionability by clinicians. The survey asked clinicians to score items on the potential benefit or harm to patients and the provider actionability of each item. Voting and surveys used 5-point Likert scales. A Pearson interdomain correlation was used. RESULTS Phase 1 identified 64 low-value items. Phase 2 narrowed this list to 7 laboratory tests, 3 medications, 4 imaging studies, and 3 disposition decisions included in the phase 3 survey (71.0% response rate). All 17 items showed a significant positive correlation between benefit and actionability (r, 0.19-0.37 [P

  14. The mosquito melanization response is implicated in defense against the entomopathogenic fungus Beauveria bassiana.

    Directory of Open Access Journals (Sweden)

    Hassan Yassine

    Full Text Available Mosquito immunity studies have focused mainly on characterizing immune effector mechanisms elicited against parasites, bacteria and more recently, viruses. However, those elicited against entomopathogenic fungi remain poorly understood, despite the ubiquitous nature of these microorganisms and their unique invasion route that bypasses the midgut epithelium, an important immune tissue and physical barrier. Here, we used the malaria vector Anopheles gambiae as a model to investigate the role of melanization, a potent immune effector mechanism of arthropods, in mosquito defense against the entomopathogenic fungus Beauveria bassiana, using in vivo functional genetic analysis and confocal microscopy. The temporal monitoring of fungal growth in mosquitoes injected with B. bassiana conidia showed that melanin eventually formed on all stages, including conidia, germ tubes and hyphae, except the single cell hyphal bodies. Nevertheless, melanin rarely aborted the growth of any of these stages and the mycelium continued growing despite being melanized. Silencing TEP1 and CLIPA8, key positive regulators of Plasmodium and bacterial melanization in A. gambiae, abolished completely melanin formation on hyphae but not on germinating conidia or germ tubes. The detection of a layer of hemocytes surrounding germinating conidia but not hyphae suggested that melanization of early fungal stages is cell-mediated while that of late stages is a humoral response dependent on TEP1 and CLIPA8. Microscopic analysis revealed specific association of TEP1 with surfaces of hyphae and the requirement of both, TEP1 and CLIPA8, for recruiting phenoloxidase to these surfaces. Finally, fungal proliferation was more rapid in TEP1 and CLIPA8 knockdown mosquitoes which exhibited increased sensitivity to natural B. bassiana infections than controls. In sum, the mosquito melanization response retards significantly B. bassiana growth and dissemination, a finding that may be exploited to

  15. Effects of varied nitrate and phosphate supply on polysaccharidic and proteinaceous gel particle production during tropical phytoplankton bloom experiments

    Science.gov (United States)

    Engel, A.; Borchard, C.; Loginova, A.; Meyer, J.; Hauss, H.; Kiko, R.

    2015-10-01

    Gel particles such as the polysaccharidic transparent exopolymer particles (TEP) and the proteinaceous Coomassie stainable particles (CSP) play an important role in marine biogeochemical and ecological processes like particle aggregation and export, or microbial nutrition and growth. So far, effects of nutrient availability or of changes in nutrient ratios on gel particle production and fate are not well understood. The tropical ocean includes large oxygen minimum zones, where nitrogen losses due to anaerobic microbial activity result in a lower supply of nitrate relative to phosphate to the euphotic zone. Here, we report of two series of mesocosm experiments that were conducted with natural plankton communities collected from the eastern tropical North Atlantic (ETNA) close to Cape Verde in October 2012. The experiments were performed to investigate how different phosphate (experiment 1, Varied P: 0.15-1.58 μmol L-1) or nitrate (experiment 2, Varied N: 1.9-21.9 μmol L-1) concentrations affect the abundance and size distribution of TEP and CSP. In the days until the bloom peak was reached, a positive correlation between gel particle abundance and Chl a concentration was determined, linking the release of dissolved gel precursors and the subsequent formation of gel particles to autotrophic production. After the bloom peak, gel particle abundance remained stable or even increased, implying a continued partitioning of dissolved into particulate organic matter after biomass production itself ceased. During both experiments, differences between TEP and CSP dynamics were observed; TEP were generally more abundant than CSP. Changes in size distribution indicated aggregation of TEP after the bloom, while newly formed CSP decomposed. Abundance of gel particles clearly increased with nitrate concentration during the second experiment, suggesting that changes in [DIN] : [DIP] ratios can affect gel particle formation with potential consequences for carbon and nitrogen

  16. Cortical modulation of short-latency TMS-evoked potentials

    Directory of Open Access Journals (Sweden)

    Domenica eVeniero

    2013-01-01

    Full Text Available Transcranial magnetic stimulation - electroencephalogram (TMS-EEG co-registration offers the opportunity to test reactivity of brain areas across distinct conditions through TMS-evoked potentials (TEPs. Several TEPs have been described, their functional meaning being largely unknown. In particular, short-latency potentials peaking at 5 (P5 and 8 (N8 ms after the TMS pulse have been recently described, but because of their huge amplitude, the problem of whether their origin is cortical or not has been opened. To gain information about these components, we employed a protocol that modulates primary motor cortex excitability (MI through an exclusively cortical phenomena: low frequency stimulation of premotor area (PMC. TMS was applied simultaneously with EEG recording from 70 electrodes. Amplitude of TEPs evoked by 200 single-pulses TMS delivered over MI at 110% of resting motor threshold was measured before and after applying 900 TMS conditioning stimuli to left premotor cortex with 1 Hz repetition rate. Single subject analyses showed reduction in TEPs amplitude after PMC conditioning in a sample of participants and increase in TEPs amplitude in two subjects. No effects were found on corticospinal excitability as recorded by motor evoked potentials (MEPs. Furthermore, correlation analysis showed an inverse relation between the effects of the conditioning protocol on P5-N8 complex amplitude and MEPs amplitude. Because the effects of the used protocol have been ascribed to a cortical interaction between premotor area and MI, we suggest that despite the sign of P5-N8 amplitude modulation is not consistent across participant, this modulation could indicate, at least in part, their cortical origin. We conclude that with an accurate experimental procedure early-latency components can be used to evaluate the reactivity of the stimulated cortex.

  17. Protein and carbohydrate exopolymer particles in the sea surface microlayer (SML

    Directory of Open Access Journals (Sweden)

    Daniel Conrad Ogilvie Thornton

    2016-08-01

    Full Text Available Exchanges of matter and energy between ocean and atmosphere occur through the sea surface microlayer (SML. The SML is the thin surface layer of the ocean at the ocean-atmosphere interface that has distinctive physical, chemical and biological properties compared with the underlying water. We measured the concentration of two types of exopolymer particles in the SML and underlying water in the Pacific Ocean off the coast of Oregon (United States during July 2011. Transparent exopolymer particles (TEP are defined by their acidic polysaccharide content, whereas Coomassie staining particles (CSP are composed of protein. TEP and CSP were ubiquitous in the SML. TEP were not significantly enriched in the SML compared with the underlying water. CSP were significantly enriched in the SML, with an enrichment factor (EF of 1.4 to 2.4. The distribution of exopolymer particles in the water and microscopic imaging indicated that TEP and CSP are distinct populations of particles rather than different chemical components of the same particles. Dissolved polysaccharides were not enriched in the SML, whereas monosaccharides had an EF of 1.2 to 1.8. Sampling occurred during the collapse of a diatom bloom, and diatoms were found both in the water column and SML. While there were living diatoms in the samples, most of the diatoms were dead and there were abundant empty frustules covered in layer of TEP. The collapsing diatom bloom was probably the source of exopolymer particles to both the SML and underlying water. Exopolymer particles are a component of the SML that may play a significant role in the marine carbon and nitrogen cycles, and the exchange of material between ocean and atmosphere.

  18. Quality-of-life scores in laparoscopic preperitoneal inguinal hernia repair.

    Science.gov (United States)

    Wennergren, John E; Plymale, Margaret; Davenport, Daniel; Levy, Salomon; Hazey, Jeffrey; Perry, Kyle A; Stigall, Kyle; Roth, J Scott

    2016-08-01

    Published support exists for using lightweight polypropylene mesh (PPM) to repair inguinal hernias with increased biocompatibility and decreased foreign body reaction and pain. However, quality of life (QOL) has not been assessed. We assess QOL in patients undergoing laparoscopic totally extraperitoneal hernia repair (TEP) with lightweight PPM. We performed an IRB-approved study of patients undergoing TEP hernia repair. Demographic information and hernia characteristics were collected perioperatively. Baseline Short Form-36 (SF-36), Carolinas Comfort Scale (CCS), and visual analog scale (VAS) for pain were performed preoperatively, and then after 1, 26, and 52 weeks. Forty-eight patients undergoing TEP with mesh were selected. Average age was 43.2 years (SD = 13.2), and average BMI was 26.1 kg/m(2) (SD = 4.3). Procedures include bilateral hernia, right inguinal hernia, and left inguinal hernia repairs. Mean scores on the CCS(®) and VAS were low during the immediate post-op period and 1 year. SF-36 mean scores for body pain, physical function, and role physical showed decreases at the postoperative survey and then subsequent increases. Pain-associated scores increased during the immediate post-op period. CCS and SF-36 scores demonstrated improvement after 1 year. There was no significant difference in VAS. Bilateral repair patients reported more pain and reduced physical function versus unilateral repairs. Patients with larger mesh reported greater pain scores and reduced physical function scores. Laparoscopic inguinal hernia repair is associated with initial declines in QOL in the postoperative period. Improvements appear in the long term. General health does not appear to be impacted by laparoscopic TEP. Smaller mesh and unilateral repairs are associated with improved QOL following laparoscopic TEP with PPM. Multiple metrics for QOL are required to reflect patient recovery.

  19. Tick Thioester-Containing Proteins and Phagocytosis Do Not Affect Transmission ofBorrelia afzeliifrom the Competent VectorIxodes ricinus.

    Science.gov (United States)

    Urbanová, Veronika; Hajdušek, Ondřej; Hönig Mondeková, Helena; Šíma, Radek; Kopáček, Petr

    2017-01-01

    The present concept of the transmission of Lyme disease from Borrelia -infected Ixodes sp. ticks to the naïve host assumes that a low number of spirochetes that manage to penetrate the midgut epithelium migrate through the hemocoel to the salivary glands and subsequently infect the host with the aid of immunomodulatory compounds present in tick saliva. Therefore, humoral and/or cellular immune reactions within the tick hemocoel may play an important role in tick competence to act as a vector for borreliosis. To test this hypothesis we have examined complement-like reactions in the hemolymph of the hard tick Ixodes ricinus against Borrelia afzelii (the most common vector and causative agent of Lyme disease in Europe). We demonstrate that I. ricinus hemolymph does not exhibit borreliacidal effects comparable to complement-mediated lysis of bovine sera. However, after injection of B. afzelii into the tick hemocoel, the spirochetes were efficiently phagocytosed by tick hemocytes and this cellular defense was completely eliminated by pre-injection of latex beads. As tick thioester-containing proteins (T-TEPs) are components of the tick complement system, we performed RNAi-mediated silencing of all nine genes encoding individual T-TEPs followed by in vitro phagocytosis assays. Silencing of two molecules related to the C3 complement component ( Ir C3-2 and Ir C3-3) significantly suppressed phagocytosis of B. afzelii , while knockdown of Ir Tep (insect type TEP) led to its stimulation. However, RNAi-mediated silencing of T-TEPs or elimination of phagocytosis by injection of latex beads in B. afzelii -infected I. ricinus nymphs had no obvious impact on the transmission of spirochetes to naïve mice, as determined by B. afzelii infection of murine tissues following tick infestation. This result supports the concept that Borrelia spirochetes are capable of avoiding complement-related reactions within the hemocoel of ticks competent to transmit Lyme disease.

  20. Evaluation of outcome of totally extra peritoneal laparoscopic inguinal hernia repair with lichtenstein open repair

    International Nuclear Information System (INIS)

    Ahmed, I.; Dian, A.; Azam, U.F.; Khan, M.

    2015-01-01

    The objective of this study was to evaluate outcome of total extraperitoneal laparoscopic inguinal hernia repair with Lichtenstein open repair in terms of postoperative pain. Study Design: Quasi experimental study. Place and Duration of Study: Surgical unit l Rawalpindi and Allied hospitals from January to June 2012. Patients and Methods: Sixty patients, with unilateral, primary, inguinal hernia were alternately allocated to undergo either total extraperitoneal (TEP) laparoscopic repair of inguinal hernia or Lichtenstein tension free, mesh repair of inguinal hernia. Pain scores at 12, 24, and 48 hours and at 7 days of follow up were noted using a visual analogue scale. Total number of intravenous injections of Diclofenac Sodium requested by the patient for pain relief was also noted. Results: At 12 hours after surgery, the mean pain scores in the TEP group were 3.1 ± 1.8 and in the Lichtenstein group they were 4.2 ± 2.1 (p 0.031). At 24 hours after surgery, the scores were 2.3 ± 1.5 and 3.1 ± 1.9 for the TEP and Lichtenstein groups, respectively (p = 0.026). At 48 hours after surgery, the mean pain scores in the TEP group were 1.5 ± 1.1 while in the Lichtenstein group they were 2.0 ± 1.6 (p = 0.041). At 7 days after surgery, the scores were 0.3 ± 0.5 in the TEP group and 0.4 ± 0.8 in the Lichtenstein group (0.137). The mean number of injection of Diclofenac Sodium required by the TEP and Lichtenstein groups was 3.1 ± 1.6 and 5.8 ± 2.2, respectively (p = 0.011). Conclusion: Less postoperative pain and requirement for analgesics were reported by patients who underwent total extraperitoneal laparoscopic repair of inguinal hernia as compared to those who underwent inguinal hernia repair by Lichtenstein tension free mesh hernioplasty. (author)

  1. Improved final predicted height with the injection of leuprolide in children with earlier puberty: A retrospective cohort study.

    Directory of Open Access Journals (Sweden)

    Yi-Chun Lin

    Full Text Available The adult height of children with early onset puberty is limited by the premature maturation of hypothalamic-pituitary-gonadal axis. To evaluate the effects of gonadotropin-releasing hormone analog (GnRHa treatment on the final height (FH and bone maturation rate (BMR in girls with early puberty (EP or idiopathic central precocious puberty (ICPP, we examined data from girls who were diagnosed with EP or ICPP and underwent GnRHa (Leuplin Depot: 3.75 mg/month at China Medical University Hospital, in Taiwan, between 2006 and 2015. Patients were observed until the achievement of FH and divided into an "EP group" (T-ep and "ICPP group" (T-icpp according to the age of onset of puberty. Eighty-seven patients were enrolled (T-ep, N = 44, puberty onset at 8-10 years; T-icpp, N = 43, puberty onset before 8 years. The demographic data of girls with EP or IPP was characterized. BMR, change in predicted final height (PFH after GnRHa treatment, target height (TH and FH were measured. After GnRHa treatment, the study groups (T-ep: 160.24±6.18 cm, T-icpp: 158.99±5.92 cm both had higher PFH than at initiation (T-ep: 159.83±7.19 cm, T-icpp: 158.58±5.93 cm. There was deceleration of BMR in both groups (T-ep: 0.57±0.39; T-icpp: 0.97±0.97 and a significant difference between the groups (p = 0.027. The gap in FH standard deviation scores (SDS and TH SDS had a significant difference in T-ep (p = 0.045 but not in T-icpp. Moreover, there was no difference in the gap of PFH SDS between the 1st and final treatment in both groups. We concluded that GnRHa decelerated BMR in girls with earlier puberty. Further prospective clinical studies are warranted.

  2. SÍNDROME DE SECRECIÓN INADECUADA DE HORMONA ANTIDIURÉTICA ASOCIADO A TROMBOEMBOLISMO DE PULMÓN: UNA CAUSA DE HIPONATREMIA NO DESCRITA EN LA LITERATURA.

    OpenAIRE

    Carlos G. Musso; Vilas M; Chiapella M; Conti P; Reynaldi J; Mombelli C; Navarro M; Frydelund S; Algranati L

    2008-01-01

    El síndrome de secreción inadecuada de hormona antidiurética (SIADH) es una condición que puede asociarse a diversas neumopatías.En el presente reporte clínico se presenta un caso de SIHAD asociado a un tromboembolismo pulmonar. Hasta donde sabemos, la asociación entre TEP y SIHAD no había sido reportada aun en la literatura, y presentamos como hipótesis etiológica la liberación de citoquinas inductoras de la secreción de vasopresina, secundaria al daño parenquimatoso pulmonar del TEP.Conclus...

  3. SÍNDROME DE SECRECIÓN INADECUADA DE HORMONA ANTIDIURÉTICA ASOCIADO A TROMBOEMBOLISMO DE PULMÓN: UNA CAUSA DE HIPONATREMIA NO DESCRITA EN LA LITERATURA.

    Directory of Open Access Journals (Sweden)

    Carlos G. Musso

    2008-01-01

    Full Text Available El síndrome de secreción inadecuada de hormona antidiurética (SIADH es una condición que puede asociarse a diversas neumopatías.En el presente reporte clínico se presenta un caso de SIHAD asociado a un tromboembolismo pulmonar. Hasta donde sabemos, la asociación entre TEP y SIHAD no había sido reportada aun en la literatura, y presentamos como hipótesis etiológica la liberación de citoquinas inductoras de la secreción de vasopresina, secundaria al daño parenquimatoso pulmonar del TEP.Conclusion: El tromboembolismo de pulmón podría ser incorporado a las causas pulmonares de SIADH.

  4. Project W-314 specific test and evaluation plan for 241-AX-B valve pit upgrade

    International Nuclear Information System (INIS)

    Hays, W.H.

    1998-01-01

    The purpose of this Specific Test and Evaluation Plan (STEP) is to provide a detailed written plan for the systematic testing of modifications made to the 241-AX-B Valve Pit by the W-314 Project. The STEP develops the outline for test procedures that verify the system's performance to the established Project design criteria. The STEP is a lower tier document based on the W-314 Test and Evaluation Plan (TEP). Testing includes Validations and Verifications (e.g., Commercial Grade Item Dedication activities), Factory Acceptance Tests (FATs), installation tests and inspections, Construction Acceptance Tests (CATs), Acceptance Test Procedures (ATPs), Pre-Operational Test Procedures (POTPs), and Operational Test Procedures (OTPs). It should be noted that POTPs are not required for testing of the transfer line addition. The STEP will be utilized in conjunction with the TEP for verification and validation

  5. Analysis of the Cross-Linking Reaction of Lignin with Triethyl Phosphate by MALDI-TOF and 13C NMR

    Directory of Open Access Journals (Sweden)

    María Cecilia Basso

    2017-06-01

    Full Text Available The reaction of condensation and cross-linking of desulfurized kraft lignin with triethyl phosphate (TEP was explored. Catechol, a simple model of the aromatic ring of lignin, and glycerol, a model compound of the aliphatic hydroyl groups of the side chain of lignin, were employed under similar reaction conditions. Solid state cross-polarisation/magic-angle spinning (CP-MAS 13C NMR and matrix assisted laser desorption ionization time-of-flight (MALDI-TOF spectroscopy studies showed that polycondensation occurs on phenolic hydroxyl groups of lignin, as well as on aliphatic hydroxyls groups of its side chain. The reactions appear to be favoured by higher temperatures and in the presence of ammonia. Preliminary adhesion tests on wood shown good hydrophobicity properties of the surface treated with lignin-TEP-based resin. Initial application tests carried out at high temperature demonstrated as good performance as metallic coating.

  6. Nuclear Fusion Fuel Cycle Research Perspectives

    International Nuclear Information System (INIS)

    Chung, Hongsuk; Koo, Daeseo; Park, Jongcheol; Kim, Yeanjin; Yun, Sei-Hun

    2015-01-01

    As a part of the International Thermonuclear Experimental Reactor (ITER) Project, we at the Korea Atomic Energy Research Institute (KAERI) and our National Fusion Research Institute (NFRI) colleagues are investigating nuclear fusion fuel cycle hardware including a nuclear fusion fuel Storage and Delivery System (SDS). To have a better knowledge of the nuclear fusion fuel cycle, we present our research efforts not only on SDS but also on the Fuel Supply System (FS), Tokamak Exhaust Processing System (TEP), Isotope Separation System (ISS), and Detritiation System (DS). To have better knowledge of the nuclear fusion fuel cycle, we presented our research efforts not only on SDS but also on the Fuel Supply System (FS), Tokamak Exhaust Processing System (TEP), Isotope Separation System (ISS), and Detritiation System (DS). Our efforts to enhance the tritium confinement will be continued for the development of cleaner nuclear fusion power plants

  7. Authoritarian Parenting and Asian Adolescent School Performance: Insights from the US and Taiwan

    Science.gov (United States)

    Pong, Suet-ling; Johnston, Jamie; Chen, Vivien

    2014-01-01

    Our study re-examines the relationship between parenting and school performance among Asian students. We use two sources of data: wave I of the Adolescent Health Longitudinal Survey (Add Health), and waves I and II of the Taiwan Educational Panel Survey (TEPS). Analysis using Add Health reveals that the Asian-American/European-American difference in the parenting–school performance relationship is due largely to differential sample sizes. When we select a random sample of European-American students comparable to the sample size of Asian-American students, authoritarian parenting also shows no effect for European-American students. Furthermore, analysis of TEPS shows that authoritarian parenting is negatively associated with children's school achievement, while authoritative parenting is positively associated. This result for Taiwanese Chinese students is similar to previous results for European-American students in the US. PMID:24850978

  8. Fiber Optic Coupled Raman Based Detection of Hazardous Liquids Concealed in Commercial Products

    Directory of Open Access Journals (Sweden)

    Michael L. Ramírez-Cedeño

    2012-01-01

    Full Text Available Raman spectroscopy has been widely proposed as a technique to nondestructively and noninvasively interrogate the contents of glass and plastic bottles. In this work, Raman spectroscopy is used in a concealed threat scenario where hazardous liquids have been intentionally mixed with common consumer products to mask its appearance or spectra. The hazardous liquids under consideration included the chemical warfare agent (CWA simulant triethyl phosphate (TEP, hydrogen peroxide, and acetone as representative of toxic industrial compounds (TICs. Fiber optic coupled Raman spectroscopy (FOCRS and partial least squares (PLS algorithm analysis were used to quantify hydrogen peroxide in whiskey, acetone in perfume, and TEP in colored beverages. Spectral data was used to evaluate if the hazardous liquids can be successfully concealed in consumer products. Results demonstrated that FOC-RS systems were able to discriminate between nonhazardous consumer products and mixtures with hazardous materials at concentrations lower than 5%.

  9. Reliability worth applied to transmission expansion planning based on ant colony system

    Energy Technology Data Exchange (ETDEWEB)

    Leite da Silva, Armando M.; Rezende, Leandro S. [Institute of Electric Systems and Energy, Federal University of Itajuba, UNIFEI (Brazil); da Fonseca Manso, Luiz A.; de Resende, Leonidas C. [Department of Electrical Engineering, Federal University of Sao Joao del Rei, UFSJ (Brazil)

    2010-12-15

    This paper proposes a new methodology to solve transmission expansion planning (TEP) problems in power system, based on the metaheuristic ant colony optimisation (ACO). The TEP problem includes the search for the least cost solution, bearing in mind investment cost and reliability worth. Reliability worth is considered through the assessment of the interruption costs represented by the index LOLC - loss of load cost. The focus of this work is the development of a tool for the multi-stage planning of transmission systems and how reliability aspects can influence on the decision-making process. The applications of the proposed methodology are illustrated through case studies carried out using a test system and a real sub-transmission network. (author)

  10. Project W-314 specific test and evaluation plan for AZ tank farm upgrades

    International Nuclear Information System (INIS)

    Hays, W.H.

    1998-01-01

    The purpose of this Specific Test and Evaluation Plan (STEP) is to provide a detailed written plan for the systematic testing of modifications made by the addition of the SN-631 transfer line from the AZ-O1A pit to the AZ-02A pit by the W-314 Project. The STEP develops the outline for test procedures that verify the system's performance to the established Project design criteria. The STEP is a lower tier document based on the W-314 Test and Evaluation P1 an (TEP). Testing includes Validations and Verifications (e.g., Commercial Grade Item Dedication activities, etc), Factory Tests and Inspections (FTIs), installation tests and inspections, Construction Tests and Inspections (CTIs), Acceptance Test Procedures (ATPs), Pre-Operational Test Procedures (POTPs), and Operational Test Procedures (OTPs). The STEP will be utilized in conjunction with the TEP for verification and validation

  11. A search for transit timing variation

    Directory of Open Access Journals (Sweden)

    Kramm U.

    2011-02-01

    Full Text Available Photometric follow-ups of transiting exoplanets (TEPs may lead to discoveries of additional, less massive bodies in extrasolar systems. This is possible by detecting and then analysing variations in transit timing of transiting exoplanets. In 2009 we launched an international observing campaign, the aim of which is to detect and characterise signals of transit timing variation (TTV in selected TEPs. The programme is realised by collecting data from 0.6-2.2-m telescopes spread worldwide at different longitudes. We present our observing strategy and summarise first results for WASP-3b with evidence for a 15 Earth-mass perturber in an outer 2:1 orbital resonance.

  12. Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets.

    Science.gov (United States)

    Best, Myron G; Sol, Nik; In 't Veld, Sjors G J G; Vancura, Adrienne; Muller, Mirte; Niemeijer, Anna-Larissa N; Fejes, Aniko V; Tjon Kon Fat, Lee-Ann; Huis In 't Veld, Anna E; Leurs, Cyra; Le Large, Tessa Y; Meijer, Laura L; Kooi, Irsan E; Rustenburg, François; Schellen, Pepijn; Verschueren, Heleen; Post, Edward; Wedekind, Laurine E; Bracht, Jillian; Esenkbrink, Michelle; Wils, Leon; Favaro, Francesca; Schoonhoven, Jilian D; Tannous, Jihane; Meijers-Heijboer, Hanne; Kazemier, Geert; Giovannetti, Elisa; Reijneveld, Jaap C; Idema, Sander; Killestein, Joep; Heger, Michal; de Jager, Saskia C; Urbanus, Rolf T; Hoefer, Imo E; Pasterkamp, Gerard; Mannhalter, Christine; Gomez-Arroyo, Jose; Bogaard, Harm-Jan; Noske, David P; Vandertop, W Peter; van den Broek, Daan; Ylstra, Bauke; Nilsson, R Jonas A; Wesseling, Pieter; Karachaliou, Niki; Rosell, Rafael; Lee-Lewandrowski, Elizabeth; Lewandrowski, Kent B; Tannous, Bakhos A; de Langen, Adrianus J; Smit, Egbert F; van den Heuvel, Michel M; Wurdinger, Thomas

    2017-08-14

    Blood-based liquid biopsies, including tumor-educated blood platelets (TEPs), have emerged as promising biomarker sources for non-invasive detection of cancer. Here we demonstrate that particle-swarm optimization (PSO)-enhanced algorithms enable efficient selection of RNA biomarker panels from platelet RNA-sequencing libraries (n = 779). This resulted in accurate TEP-based detection of early- and late-stage non-small-cell lung cancer (n = 518 late-stage validation cohort, accuracy, 88%; AUC, 0.94; 95% CI, 0.92-0.96; p swarm intelligence may also benefit the optimization of diagnostics readout of other liquid biopsy biosources. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  13. Authoritarian Parenting and Asian Adolescent School Performance: Insights from the US and Taiwan.

    Science.gov (United States)

    Pong, Suet-Ling; Johnston, Jamie; Chen, Vivien

    2010-01-01

    Our study re-examines the relationship between parenting and school performance among Asian students. We use two sources of data: wave I of the Adolescent Health Longitudinal Survey (Add Health), and waves I and II of the Taiwan Educational Panel Survey (TEPS). Analysis using Add Health reveals that the Asian-American/European-American difference in the parenting-school performance relationship is due largely to differential sample sizes. When we select a random sample of European-American students comparable to the sample size of Asian-American students, authoritarian parenting also shows no effect for European-American students. Furthermore, analysis of TEPS shows that authoritarian parenting is negatively associated with children's school achievement, while authoritative parenting is positively associated. This result for Taiwanese Chinese students is similar to previous results for European-American students in the US.

  14. Eastern Band of Cherokee Strategic Energy Plan

    Energy Technology Data Exchange (ETDEWEB)

    Souther Carolina Institute of energy Studies-Robert Leitner

    2009-01-30

    The Eastern Band of Cherokee Indians was awarded a grant under the U.S. Department of Energy Tribal Energy Program (TEP) to develop a Tribal Strategic Energy Plan (SEP). The grant, awarded under the “First Steps” phase of the TEP, supported the development of a SEP that integrates with the Tribe’s plans for economic development, preservation of natural resources and the environment, and perpetuation of Tribal heritage and culture. The Tribe formed an Energy Committee consisting of members from various departments within the Tribal government. This committee, together with its consultant, the South Carolina Institute for Energy Studies, performed the following activities: • Develop the Tribe’s energy goals and objectives • Establish the Tribe’s current energy usage • Identify available renewable energy and energy efficiency options • Assess the available options versus the goals and objectives • Create an action plan for the selected options

  15. Development of the 2007 Chemical Decontaminant Source Document

    Science.gov (United States)

    2009-03-01

    be calculated using the contact sampler results (note definition as total measured agent, evaporative loss between touches is not included). The...Chemical Agent Simulant Specific DEM diethyl malonate MeS methyl salicylate PEG200 Polyethylene glycol 200 TEP triethyl phosphate Group 6...section contains the definitions for key terminology in this document. Some of the definitions are focused on the specific use or context of the test

  16. Capabilities Report 2012, West Desert Test Center

    Science.gov (United States)

    2012-03-12

    Huachuca, Arizona; Redstone Test Center, Redstone Arsenal, Alabama; White Sands Test Center, White Sands Missile Range, New Mexico ; and Yuma Proving Ground... TPP ). Biological simulants may include Bacillus atrophaeus (BG), an agent of biological origin, while a fluorescent particle (FP) simulant, such...Vapor Concentrations Continuous Vapor Challenge Time Duration Tested TEP .01 to .0008 mg/m³ 3 days TPP .0002 mg/m³ 30 hours MeS 10 to

  17. Project W-314 Specific Test and Evaluation Plan for 200E Waste Transfer System

    International Nuclear Information System (INIS)

    HAMMERS, J.S.

    2000-01-01

    The purpose of this Specific Test and Evaluation Plan (STEP) is to provide a detailed written plan for the systematic testing of the newly constructed 200E Waste Transfer System in the W-314 Project. The STEP provides the outline for test and evaluation methods that verify the system's performance and compliance to the established Project design criteria. The STEP is a ''lower tier'' document based on the W-314 Test and Evaluation Plan (TEP)

  18. Reaction

    African Journals Online (AJOL)

    raoul

    12 janv. 2012 ... Key words: Métastase, rate, colon, carcinome. Received: 28/12/2011 - Accepted: 09/01/2012 - Published: ... tomodensitométriques au moment du diagnostic du cancer primitif ou lors du suivi radiologique régulier des patients atteints de cancers. Le recours à la TEP-FDG couplée au scanner serait d'un ...

  19. CRaTER: The Cosmic Ray Telescope for the Effects of Radiation Experiment on the Lunar Reconnaissance Orbiter Mission

    OpenAIRE

    Spence, H. E.; Case, A. W.; Golightly, M. J.; Heine, T.; Larsen, B. A.; Blake, J. B.; Caranza, P.; Crain, W. R.; George, J.; Lalic, M.; Lin, A.; Looper, M. D.; Mazur, J. E.; Salvaggio, D.; Kasper, J. C.

    2009-01-01

    The Cosmic Ray Telescope for the Effects of Radiation (CRaTER) on the Lunar Reconnaissance Orbiter (LRO) characterizes the radiation environment to be experienced by humans during future lunar missions. CRaTER measures the effects of ionizing energy loss in matter due to penetrating solar energetic protons (SEP) and galactic cosmic rays (GCR), specifically in silicon solid-state detectors and after interactions with tissue-equivalent plastic (TEP), a synthetic analog of human tissue. The CRaT...

  20. Michales AAF, Dugway, Utah. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A - F

    Science.gov (United States)

    1974-03-21

    NAME YEARS MONTT 4/ 0 PAGE 2 _1oo-17CZ0 HOURS IL. S. Td Te,,p WET BULB TEMPERATURE DEPRESSION (F) -TOTAL TOTAL D _Po -4 - -- I ; . o -" ""- a...129 180 l 28/ 271 ’ _t .1_49] 49 21 871 160 ___ 21 F , , 1 1 2 7 06 a / 15 12 1jj 1 5 . Iercn, (X) zz X X ’ No b , Mean No. ol Houis with

  1. Effects of varied nitrate and phosphate supply on polysaccharidic and proteinaceous gel particles production during tropical phytoplankton bloom experiments

    Science.gov (United States)

    Engel, A.; Borchard, C.; Loginova, A.; Meyer, J.; Hauss, H.; Kiko, R.

    2015-04-01

    It has been suggested that oxygen minimum zones (OMZ) will expand in the tropical oceans as a result of global change with potential consequences for marine element cycling, such as an increase in anaerobic nitrogen loss, resulting in a lower supply of nitrate relative to phosphate to the euphotic zone. So far, the effects of changes in nutrient ratios on organic matter recycling and export fluxes are not well understood. Here, were investigated how different phosphate (Varied P: 0.15-1.58 μmol L-1) or nitrate (Varied N: 1.9-21.9 μmol L-1) concentrations affect the abundance and size distribution of polysaccharidic transparent exopolymer particles (TEP), which are suggested to enhance particle aggregation and export fluxes, and on proteinaceous coomassie stainable particles (CSP), a supposedly good substrate for heterotrophic bacteria. Two series of mesocosm bloom experiments were conducted with natural plankton communities collected from the Eastern Tropical North Atlantic (ETNA) close to Cape Verde in October 2012. Until bloom peak, a positive correlation between gel particle abundance and Chl a concentration was determined, linking the release of dissolved gel precursors and the subsequent formation of gel particles to autotrophic production. After bloom peak, gel particle abundance remained stable or even increased, implying a continued partitioning of dissolved into particulate organic matter after biomass production itself ceased. During both experiments, differences between TEP and CSP dynamics were observed; TEP were generally more abundant than CSP. Changes in size distribution indicated aggregation of TEP during the bloom, while newly formed CSP decomposed. Abundance of gel particles clearly increased with nitrate concentration during the second experiment, suggesting that changes in [DIN]:[DIP] ratios can affect gel particle formation with potential consequences for carbon and nitrogen cycling as well as food web dynamics in tropical ecosystems.

  2. Data Fusion Analysis for Range Test Validation System

    Science.gov (United States)

    2010-07-14

    for use in SPIDAR was the lightweight chemical detector (LCD-3™) available from Smiths Detection, shown in Figure 1. The LCD detector is a pulse ...first; N3 - north third; N2 - north second. bA - 2, 3, 10, ; B - 1 ough 12; A - not ava cTEP - trie ethyl salic late; AA - acid. dC - 40 kg t sta r a

  3. Contribution of the modulation of intensity and the optimization to deliver a dose adapted to the biological heterogeneities

    International Nuclear Information System (INIS)

    Kubs, F.

    2007-10-01

    The recent progress in functional imaging by Positron Emission Tomography (TEP) opens new perspectives in the delineation of target volumes in radiotherapy. The functional data is major; we can intend to adapt the irradiation doses on the tumor activity (TA) and to perform a dose escalation. Our objectives were (i) to characterize the TEP threshold, by quantifying the uncertainties of the target volume contour according to the lesion size and the threshold contour level, (ii) to set up the geometry suited to perform a high-precision irradiation based on the TA, (iii) to estimate the dosimetric impact of this new protocol and (iv) to verify that dosimetry is perfectly distributed. Three original phantoms were specially created to satisfy the constraints met, as well as two virtual phantoms containing 3 dose levels (dose level 3 = TA). Our results showed the importance of the effect threshold-volume on the planning in radiotherapy. To use this irradiation method, the diameter of 1 cm for the third level was able to be reached. A dose escalation of 20 Gy was possible between the second (70 Gy) and the third level (90 Gy). The dosimetric impact estimated on two real cases was suitable - increase of COIN (conformal index) from 0.6 to 0.8 and decrease of NTCP (normal tissue complication probability) of a factor 5 -. In absolute and relative dosimetry, the clinical tolerances were respected. So all the treatment process, going from the diagnosis with the TEP to reveal the TA, to the patient treatment made beforehand on phantom, and going through the ballistic and the dose calculation, was estimated and validated according to our objective to adapt the irradiation to the biological heterogeneities. However such high doses should be carefully estimated before being prescribed clinically and progress is also expected in imaging, because the minimal size which we can irradiate is on the limit of the resolution TEP. (author)

  4. Graphene oxide/MnO2 nanocomposite as destructive adsorbent of nerve-agent simulants in aqueous media

    Czech Academy of Sciences Publication Activity Database

    Šťastný, Martin; Tolasz, Jakub; Štengl, Václav; Henych, Jiří; Žižka, D.

    2017-01-01

    Roč. 412, AUG (2017), s. 19-28 ISSN 0169-4332 R&D Projects: GA MŠk(CZ) LM2015073 Institutional support: RVO:61388980 Keywords : Graphene oxide * Manganese oxide * Nanocomposite * Destructive adsorption * Nerve agent simulants * Dimethyl methyl phosphonate (DMMP) * Triethyl phosphate (TEP) Subject RIV: CA - Inorganic Chemistry OBOR OECD: Inorganic and nuclear chemistry Impact factor: 3.387, year: 2016

  5. Transspinal constant-current long-lasting stimulation: a new method to induce cortical and corticospinal plasticity

    Science.gov (United States)

    Dixon, Luke; Santora, Danielle; Ibrahim, Mohamed M.

    2015-01-01

    Functional neuroplasticity in response to stimulation and motor training is a well-established phenomenon. Transcutaneous stimulation of the spine is used mostly to alleviate pain, but it may also induce functional neuroplasticity, because the spinal cord serves as an integration center for descending and ascending neuronal signals. In this work, we examined whether long-lasting noninvasive cathodal (c-tsCCS) and anodal (a-tsCCS) transspinal constant-current stimulation over the thoracolumbar enlargement can induce cortical, corticospinal, and spinal neuroplasticity. Twelve healthy human subjects, blind to the stimulation protocol, were randomly assigned to 40 min of c-tsCCS or a-tsCCS. Before and after transspinal stimulation, we established the afferent-mediated motor evoked potential (MEP) facilitation and the subthreshold transcranial magnetic stimulation (TMS)-mediated flexor reflex facilitation. Recruitment input-output curves of MEPs and transspinal evoked potentials (TEPs) and postactivation depression of the soleus H reflex and TEPs was also established. We demonstrate that both c-tsCCS and a-tsCCS decrease the afferent-mediated MEP facilitation and alter the subthreshold TMS-mediated flexor reflex facilitation in a polarity-dependent manner. Both c-tsCCS and a-tsCCS increased the tibialis anterior MEPs recorded at 1.2 MEP resting threshold, intermediate, and maximal intensities and altered the recruitment input-output curve of TEPs in a muscle- and polarity-dependent manner. Soleus H-reflex postactivation depression was reduced after a-tsCCS and remained unaltered after c-tsCCS. No changes were found in the postactivation depression of TEPs after c-tsCCS or a-tsCCS. Our findings reveal that c-tsCCS and a-tsCCS have distinct effects on cortical and corticospinal excitability. This method can be utilized to induce targeted neuroplasticity in humans. PMID:26108955

  6. Release of dissolved carbohydrates by Emiliania huxleyi and formation of transparent exopolymer particles depend on algal life cycle and bacterial activity.

    Science.gov (United States)

    Van Oostende, Nicolas; Moerdijk-Poortvliet, Tanja C W; Boschker, Henricus T S; Vyverman, Wim; Sabbe, Koen

    2013-05-01

    The coccolithophore Emiliania huxleyi plays a pivotal role in the marine carbon cycle. However, we have only limited understanding of how its life cycle and bacterial interactions affect the production and composition of dissolved extracellular organic carbon and its transfer to the particulate pool. We traced the fate of photosynthetically fixed carbon during phosphate-limited stationary growth of non-axenic, calcifying E. huxleyi batch cultures, and more specifically the transfer of this carbon to bacteria and to dissolved high molecular weight neutral aldoses (HMW NAld) and extracellular particulate carbon. We then compared the dynamics of dissolved carbohydrates and transparent exopolymer particles (TEP) between cultures of non-axenic and axenic diploid E. huxleyi. In addition, we present the first data on extracellular organic carbon in (non-axenic) haploid E. huxleyi cultures. Bacteria enhanced the accumulation of dissolved polysaccharides and altered the composition of dissolved HMW NAld, while they also stimulated the formation of TEP containing high densities of charged polysaccharides in diploid E. huxleyi cultures. In haploid E. huxleyi cultures we found a more pronounced accumulation of dissolved carbohydrates, which had a different NAld composition than the diploid cultures. TEP formation was significantly lower than in the diploid cultures, despite the presence of bacteria. In diploid E. huxleyi cultures, we measured a high level of extracellular release of organic carbon (34-76%), retrieved mainly in the particulate pool instead of the dissolved pool. Enhanced formation of sticky TEP due to bacteria-alga interactions, in concert with the production of coccoliths, suggests that especially diploid E. huxleyi blooms increase the efficiency of export production in the ocean during dissolved phosphate-limited conditions. © 2012 Society for Applied Microbiology and Blackwell Publishing Ltd.

  7. Authoritarian Parenting and Asian Adolescent School Performance: Insights from the US and Taiwan

    OpenAIRE

    Pong, Suet-ling; Johnston, Jamie; Chen, Vivien

    2010-01-01

    Our study re-examines the relationship between parenting and school performance among Asian students. We use two sources of data: wave I of the Adolescent Health Longitudinal Survey (Add Health), and waves I and II of the Taiwan Educational Panel Survey (TEPS). Analysis using Add Health reveals that the Asian-American/European-American difference in the parenting–school performance relationship is due largely to differential sample sizes. When we select a random sample of European-American st...

  8. Stomaplasty-anterior advancement flap and lateral splaying of trachea, a simple and effective technique

    Directory of Open Access Journals (Sweden)

    Trivedi N

    2008-01-01

    Full Text Available Background: Stomal stenosis after laryngectomy is a common and distressing complication. Once sets in, it is generally progressive, causes problems and needs active intervention. Aim: To evaluate effectiveness of new simple method of stomaplasty in solving troublesome complication of stoma stenosis. Settings and Design: Charts of eight patients who underwent modified stomaplasty and completed 1 year were reviewed. Materials and Methods: A modified anterior advancement flap and lateral splaying of trachea for stoma plasty are described. This involves excision of scar tissue of the anterior two-third of trachea and interposition of the defect with an inferiorly based triangular skin flap. The tracheo-esophageal-prosthesis (TEP site is left untouched. Statistical Analysis: Outcome were measured in relation with need for further stenting or any other revision procedure required and ability to use TEP for speech production. Results: Eight patients underwent stoma revision surgery. Median preprocedure stoma diameter was 10 mm vertically (range 8-12 mm and 6 mm horizontally (range 5-10 mm. This could be improved to 25 mm (range 22-30 mm vertically and 16 mm (range 14-20 mm horizontally after stoma revision. At 1-year follow-up, the median measurements were 20 mm (range 16-26 vertically and 14 mm (range 12-18 horizontally. Postprocedure, one patient required intermittent stenting at nighttime. All patients could use the TEP effectively. One patient who underwent salvage laryngectomy following chemoradiotherapy developed flap dehiscence. Conclusions: This is a simple and effective technique for stomaplasty. All patients treated with this technique had adequately large stoma for breathing and use of TEP.

  9. An implementation of modified scatter search algorithm to transmission expansion planning

    OpenAIRE

    MEYMAND, Majid ZEINADDINI; RASHIDINEJAD, Masoud; KHORASANI, Hamid

    2011-01-01

    Transmission network expansion planning (TNEP) is one of the most important tasks in the field of power systems, especially in deregulated power system environments. TNEP is a nonlinear mixed integer programming problem that can be solved via hybrid heuristic algorithms. This paper presents a modified scatter search algorithm (MSSA) to reinforce the ordinary scatter search algorithm (SSA) to be equipped for handling large scale transmission expansion planning (TEP) problems. The prop...

  10. Worldwide Report, Epidemiology

    Science.gov (United States)

    1985-10-09

    Guadalajara 59 62 63 63 64 64 64 66 - d - Briefs Veracruz Leprosy Cases 67 Tampico Antidengue Measures 67 NIGERIA Surveys Show Diarrhea on...The sale of eatables and meat shops in the affected areas was closed today. Water and food articles have been sent for food culture to the Institute...medically due to em- barrassment or complications." 7717 CSO: 5400/2085 66 JPRS-TEP-85-017 9 October 1985 MEXICO BRIEFS VERACRUZ LEPROSY CASES

  11. Prevention of Low Back Pain in the Military: A Randomized Clinical Trial

    Science.gov (United States)

    2011-06-01

    Initial Entry Training ( IET ), Low Back Pain (LBP) Core Stabilization Exercise Program (CSEP), Traditional Exercise Program (TEP), and Psychosocial...education (PSEP) c = number of companies, m = median of # of soldiers per company, r = min – max, n = total number of soldiers. Soldiers in IET (n...Trial. Clin Trials 2005, 2(5):443-52. 5. Loftin WA, Barnett SK, Bunn PS, Sullivan P: Recruitment and retention of rural African Americans in diabetes

  12. Natural oil slicks fuel surface water microbial activities in the northern Gulf of Mexico.

    Science.gov (United States)

    Ziervogel, Kai; D'Souza, Nigel; Sweet, Julia; Yan, Beizhan; Passow, Uta

    2014-01-01

    We conducted a series of roller tank incubations with surface seawater from the Green Canyon oil reservoir, northern Gulf of Mexico, amended with either a natural oil slick (GCS-oil) or pristine oil. The goal was to test whether bacterial activities of natural surface water communities facilitate the formation of oil-rich marine snow (oil snow). Although oil snow did not form during any of our experiments, we found specific bacterial metabolic responses to the addition of GCS-oil that profoundly affected carbon cycling within our 4-days incubations. Peptidase and β-glucosidase activities indicative of bacterial enzymatic hydrolysis of peptides and carbohydrates, respectively, were suppressed upon the addition of GCS-oil relative to the non-oil treatment, suggesting that ascending oil and gas initially inhibits bacterial metabolism in surface water. Biodegradation of physically dispersed GCS-oil components, indicated by the degradation of lower molecular weight n-alkanes as well as the rapid transformation of particulate oil-carbon (C: N >40) into the DOC pool, led to the production of carbohydrate- and peptide-rich degradation byproducts and bacterial metabolites such as transparent exopolymer particles (TEP). TEP formation was highest at day 4 in the presence of GCS-oil; in contrast, TEP levels in the non-oil treatment already peaked at day 2. Cell-specific enzymatic activities closely followed TEP concentrations in the presence and absence of GCS-oil. These results demonstrate that the formation of oil slicks and activities of oil-degrading bacteria result in a temporal offset of microbial cycling of organic matter, affecting food web interactions and carbon cycling in surface waters over cold seeps.

  13. U.S. Army Medical Department Journal (January-March 2004)

    Science.gov (United States)

    2004-03-01

    evaluate mutagenic potential of a product and include the Salmonella-E. coli/mammalian-microsome reverse mutation assay, mouse micronucleus assay, mouse...lymphoma forward mutation assay, chromosomal aberrations in Chinese hamster ovary cells, and rodent dominant lethal assay. The TEP is currently...health care providers in staying current on dietary supplements. The dietary supplement industry is a chameleon -like business determined to make a

  14. Hydrogen absorption and hydrogen-induced phase-separation in amorphous Zr[sub 50]Ni[sub 50-x]Cu[sub x] alloys

    Energy Technology Data Exchange (ETDEWEB)

    Bakonyi, I. (Hungarian Academy of Sciences, Budapest (Hungary). Research Inst. for Solid State Physics); Toth-Kadar, E. (Hungarian Academy of Sciences, Budapest (Hungary). Research Inst. for Solid State Physics); Nagy, I. (Hungarian Academy of Sciences, Budapest (Hungary). Research Inst. for Solid State Physics); Toth, J. (Hungarian Academy of Sciences, Budapest (Hungary). Research Inst. for Solid State Physics); Tompa, K. (Hungarian Academy of Sciences, Budapest (Hungary). Research Inst. for Solid State Physics); Lovas, A. (Hungarian Academy of Sciences, Budapest (Hungary). Research Inst. for Solid State Physics); Cziraki, A. (Eoetvoes Univ., Budapest (Hungary). Inst. for Solid State Physics); Fogarassay, B. (Eoetvoes Univ., Budapest (Hungary). Inst. for Solid State Physics); Wiesinger, G. (Technische Univ., Vienna (Austria). Inst. fuer Experimentalphysik)

    1994-01-01

    The hydrogen absorption from the gas phase was investigated for melt-quenched Zr[sub 50]Ni[sub 50-x]Cu[sub x] (0[<=]x[<=]25) amorphous alloys by weighing, by thermoelectric power (TEP) and magnetization measurements aand by electron microscopy. A strongly nonmonotonous behaviour been observed, both as a function of the charging time and the Cu-content, for several materials characteristics and also for the nature of the hydrogen-induced phase-separation. (orig.)

  15. In vitro study of bioactivity of homemade tissue-engineered periosteum

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Lin, E-mail: bonezl@sina.com [Orthopaedic Department, Jinshan Branch of the Sixth People' s Hospital of Shanghai, Shanghai Jiao Tong University, Shanghai 201500 (China); Zhao, Junli [Department of Nephrology, Shanghai ZhouPu Hospital, Shanghai 201318 (China); Yu, Jiajia; Zhao, Xiaofei [Orthopaedic Institute, The Second Hospital of Lanzhou University, Lanzhou 730030 (China); Chen, Qi; Huang, Yanfeng [Orthopaedic Department, Jinshan Branch of the Sixth People' s Hospital of Shanghai, Shanghai Jiao Tong University, Shanghai 201500 (China)

    2016-01-01

    This study was aimed to evaluate in vitro bioactivity of tissue-engineered periosteum (TEP) which was fabricated by coupling either rabbits' MSCs or osteodifferentiated MSCs (O-MSCs) with porcine small intestinal submucosa (SIS), and that produced two kinds of TEPs (M1 = MSCs + SIS and M2 = Osteoblast + SIS). The cell adherence was observed under scanning electronic microscopy (SEM). Cell proliferation was measured by 3-[4,5-dimethylthiazol-2yl]-2,5-diphenyl-2 H-tetrazoliumbromide (MTT) test. In vitro osteogenetic potential of TEPs was evaluated kinetically at 0, 5, 10 and 15 d by measuring alkaline phosphatase (ALP) activity, and semi-quantitative assay of osteocalcin and collagen type I expression with Western blot. SEM indicated that either MSCs or O-MSCs could adhere and survive on SIS, but MTT test revealed that SIS was more preferable for O-MSCs than MSCs in proliferative aspect. In contrast, ALP activity, osteocalcin and collagen type I expression of M2 were higher than M1 in general. Kinetically, osteocalcin and collagen type I expression demonstrated a continuous increase, while ALP activity of both groups was displayed an early peak around the fifth day, followed a decrease trend. In conclusion, TEP, especially M2, has an active osteogenesis and is promising for in vivo bone defect reparation via a supposed biomimetic procedure of intramembranous ossification. - Highlights: • Artificial periosteum was constructed by coupling of osteogenetic induced MSCs and SIS. • Seeding cells showed good attachment and active proliferation on the surface of SIS scaffold. • Artificial periosteum expresses ALP, osteocalcin and collagen type I in vitro.

  16. Contribution of the modulation of intensity and the optimization to deliver a dose adapted to the biological heterogeneities; Apport de la modulation d'intensite et de l'optimisation pour delivrer une dose adaptee aux heterogeneites biologiques

    Energy Technology Data Exchange (ETDEWEB)

    Kubs, F

    2007-10-15

    The recent progress in functional imaging by Positron Emission Tomography (TEP) opens new perspectives in the delineation of target volumes in radiotherapy. The functional data is major; we can intend to adapt the irradiation doses on the tumor activity (TA) and to perform a dose escalation. Our objectives were (i) to characterize the TEP threshold, by quantifying the uncertainties of the target volume contour according to the lesion size and the threshold contour level, (ii) to set up the geometry suited to perform a high-precision irradiation based on the TA, (iii) to estimate the dosimetric impact of this new protocol and (iv) to verify that dosimetry is perfectly distributed. Three original phantoms were specially created to satisfy the constraints met, as well as two virtual phantoms containing 3 dose levels (dose level 3 = TA). Our results showed the importance of the effect threshold-volume on the planning in radiotherapy. To use this irradiation method, the diameter of 1 cm for the third level was able to be reached. A dose escalation of 20 Gy was possible between the second (70 Gy) and the third level (90 Gy). The dosimetric impact estimated on two real cases was suitable - increase of COIN (conformal index) from 0.6 to 0.8 and decrease of NTCP (normal tissue complication probability) of a factor 5 -. In absolute and relative dosimetry, the clinical tolerances were respected. So all the treatment process, going from the diagnosis with the TEP to reveal the TA, to the patient treatment made beforehand on phantom, and going through the ballistic and the dose calculation, was estimated and validated according to our objective to adapt the irradiation to the biological heterogeneities. However such high doses should be carefully estimated before being prescribed clinically and progress is also expected in imaging, because the minimal size which we can irradiate is on the limit of the resolution TEP. (author)

  17. Natural oil slicks fuel surface water microbial activities in the northern Gulf of Mexico

    Directory of Open Access Journals (Sweden)

    Kai eZiervogel

    2014-05-01

    Full Text Available We conducted a series of roller tank incubations with surface seawater from the Green Canyon oil reservoir, northern Gulf of Mexico, amended with either a natural oil slick (GCS-oil or pristine oil. The goal was to test whether bacterial activities of natural surface water communities facilitate the formation of oil-rich marine snow (oil snow. Although oil snow did not form during any of our experiments, we found specific bacterial metabolic responses to the addition of GCS-oil that profoundly affected carbon cycling within our 4-days incubations. Peptidase and -glucosidase activities indicative of bacterial enzymatic hydrolysis of peptides and carbohydrates, respectively, were suppressed upon the addition of GCS-oil relative to the non-oil treatment, suggesting that ascending oil and gas initially inhibits bacterial metabolism in surface water. Biodegradation of physically dispersed GCS-oil components indicated by the degradation of lower molecular weight n-alkanes as well as the rapid transformation of particulate oil-carbon (C: N >40 into the DOC pool, led to the production of carbohydrate- and peptide-rich degradation byproducts and bacterial metabolites such as transparent exopolymer particles (TEP. TEP formation was highest at day 4 in the presence of GCS-oil; in contrast, TEP levels in the non-oil treatment already peaked at day 2. Cell-specific enzymatic activities closely followed TEP concentrations in the presence and absence of GCS-oil. These results demonstrate that the formation of oil slicks and activities of oil-degrading bacteria result in a temporal offset of microbial cycling of organic matter, affecting food web interactions and carbon cycling in surface waters over cold seeps.

  18. TNFα promotes CAR-dependent migration of leukocytes across epithelial monolayers

    Science.gov (United States)

    Morton, Penny E.; Hicks, Alexander; Ortiz-Zapater, Elena; Raghavan, Swetavalli; Pike, Rosemary; Noble, Alistair; Woodfin, Abigail; Jenkins, Gisli; Rayner, Emma; Santis, George; Parsons, Maddy

    2016-01-01

    Trans-epithelial migration (TEpM) of leukocytes during inflammation requires engagement with receptors expressed on the basolateral surface of the epithelium. One such receptor is Coxsackie and Adenovirus Receptor (CAR) that binds to Junctional Adhesion Molecule-like (JAM-L) expressed on leukocytes. Here we provide the first evidence that efficient TEpM of monocyte-derived THP-1 cells requires and is controlled by phosphorylation of CAR. We show that TNFα acts in a paracrine manner on epithelial cells via a TNFR1-PI3K-PKCδ pathway leading to CAR phosphorylation and subsequent transmigration across cell junctions. Moreover, we show that CAR is hyper-phosphorylated in vivo in acute and chronic lung inflammation models and this response is required to facilitate immune cell recruitment. This represents a novel mechanism of feedback between leukocytes and epithelial cells during TEpM and may be important in controlling responses to pro-inflammatory cytokines in pathological settings. PMID:27193388

  19. Aquifer Treatment of Sea Water to Remove Natural Organic Matter Before Desalination

    KAUST Repository

    Dehwah, Abdullah

    2016-10-18

    An investigation of a sea water reverse osmosis desalination facility located in western Saudi Arabia has shown that aquifer treatment of the raw sea water provides a high degree of removal of natural organic matter (NOM) that causes membrane biofouling. The aquifer is a carbonate system that has a good hydraulic connection to the sea and 14 wells are used to induce sea water movement 400 to 450 m from the sea to the wells. During aquifer transport virtually all of the algae, over 90% of the bacteria, over 90% of the biopolymer fraction of NOM, and high percentages of the humic substance, building blocks, and some of the low molecular weight fractions of NOM are removed. Between 44 and over 90% of the transparent exopolymer particles (TEP) are removed with a corresponding significant reduction in concentration of the colloidal fraction of TEP. The removal rate for TEP appears to be greater in carbonate aquifers compared to siliciclastic systems. Although the production wells range in age from 4 months to 14 years, no significant difference in the degree of water treatment provided by the aquifer was found.

  20. Subsurface intake systems: Green choice for improving feed water quality at SWRO desalination plants, Jeddah, Saudi Arabia

    KAUST Repository

    Dehwah, Abdullah

    2015-10-25

    An investigation of three seawater reverse osmosis facilities located along the shoreline of the Red Sea of Saudi Arabia that use well intake systems showed that the pumping-induced flow of raw seawater through a coastal aquifer significantly improves feed water quality. A comparison between the surface seawater and the discharge from the wells shows that turbidity, algae, bacteria, total organic carbon, most fractions of natural organic matter (NOM), and particulate and colloidal transparent exopolymer particles (TEP) have significant reductions in concentration. Nearly all of the algae, up to 99% of the bacteria, between 84 and 100% of the biopolymer fraction of NOM, and a high percentage of the TEP were removed during transport. The data suggest that the flowpath length and hydraulic retention time in the aquifer play the most important roles in removal of the organic matter. Since the collective concentrations of bacteria, biopolymers, and TEP in the intake seawater play important roles in the biofouling of SWRO membranes, the observed reductions suggest that the desalination facilities that use well intakes systems will have a potentially lower fouling rate compared to open-ocean intake systems. Furthermore, well intake system intakes also reduce the need for chemical usage during complex pretreatment systems required for operation of SWRO facilities using open-ocean intakes and reduce environmental impacts.

  1. Technology-enhanced practice for patients with chronic cardiac disease: home implementation and evaluation.

    Science.gov (United States)

    Brennan, Patricia Flatley; Casper, Gail R; Burke, Laura J; Johnson, Kathy A; Brown, Roger; Valdez, Rupa S; Sebern, Marge; Perez, Oscar A; Sturgeon, Billie

    2010-01-01

    This 3-year field experiment engaged 60 nurses and 282 patients in the design and evaluation of an innovative home-care nursing model, referred to as technology-enhanced practice (TEP). Nurses using TEP augmented the usual care with a web-based resource (HeartCareII) that provided patients with self-management information, self-monitoring tools, and messaging services. Patients exposed to TEP demonstrated better quality of life and self-management of chronic heart disease during the first 4 weeks, and were no more likely than patients in usual care to make unplanned visits to a clinician or hospital. Both groups demonstrated the same long-term symptom management and achievements in health status. This project provides new evidence that the purposeful creation of patient-tailored web resources within a hospital portal is possible; that nurses have difficulty with modifying their practice routines, even with a highly-tailored web resource; and that the benefits of this intervention are more discernable in the early postdischarge stages of care. Copyright © 2010 Elsevier Inc. All rights reserved.

  2. Subsurface intake systems: Green choice for improving feed water quality at SWRO desalination plants, Jeddah, Saudi Arabia.

    Science.gov (United States)

    Dehwah, Abdullah H A; Missimer, Thomas M

    2016-01-01

    An investigation of three seawater reverse osmosis facilities located along the shoreline of the Red Sea of Saudi Arabia that use well intake systems showed that the pumping-induced flow of raw seawater through a coastal aquifer significantly improves feed water quality. A comparison between the surface seawater and the discharge from the wells shows that turbidity, algae, bacteria, total organic carbon, most fractions of natural organic matter (NOM), and particulate and colloidal transparent exopolymer particles (TEP) have significant reductions in concentration. Nearly all of the algae, up to 99% of the bacteria, between 84 and 100% of the biopolymer fraction of NOM, and a high percentage of the TEP were removed during transport. The data suggest that the flowpath length and hydraulic retention time in the aquifer play the most important roles in removal of the organic matter. Since the collective concentrations of bacteria, biopolymers, and TEP in the intake seawater play important roles in the biofouling of SWRO membranes, the observed reductions suggest that the desalination facilities that use well intakes systems will have a potentially lower fouling rate compared to open-ocean intake systems. Furthermore, well intake system intakes also reduce the need for chemical usage during complex pretreatment systems required for operation of SWRO facilities using open-ocean intakes and reduce environmental impacts. Copyright © 2015 Elsevier Ltd. All rights reserved.

  3. Size-effect features on the magnetothermopower of bismuth nanowires

    International Nuclear Information System (INIS)

    Condrea, E.; Nicorici, A.

    2011-01-01

    Full text: In this work we have studied the magnetic field dependence of the thermopower (TEP) and resistance of glass-coated Bi wires with diameter (d) from 100 nm to at 1.5 μm below 80 K. Nanowires have anomalously large values of the thermopower (+100 μV K.1) and relatively high effective resistivities, but their frequencies of SdH oscillations remain those of bulk Bi. The TEP stays positive in longitudinal magnetic fields up to 15 T, where the surface scattering of charge carriers is negligible. Our analysis shows that the anomalous thermopower has a diffusion origin and is a consequence of the microstructure rather than the result of the strong scattering of electrons by the wire walls. The intensities of field at which the size-effect features appear on the magnetothermopower curves correspond to a value at which the diameter of the hole cyclotron orbit equals d. Size-effect features were observed only for set of nanowires with d = 100-350 nm, where diffusion TEP is dominant. The contribution of the phonon-drag effect was observed in a wire with diameter larger than 400 nm and becomes dominant at diameter of 1 μm. (authors)

  4. A novel strategy to improve protein secretion via overexpression of the SppA signal peptide peptidase in Bacillus licheniformis.

    Science.gov (United States)

    Cai, Dongbo; Wang, Hao; He, Penghui; Zhu, Chengjun; Wang, Qin; Wei, Xuetuan; Nomura, Christopher T; Chen, Shouwen

    2017-04-24

    Signal peptide peptidases play an important role in the removal of remnant signal peptides in the cell membrane, a critical step for extracellular protein production. Although these proteins are likely a central component for extracellular protein production, there has been a lack of research on whether protein secretion could be enhanced via overexpression of signal peptide peptidases. In this study, both nattokinase and α-amylase were employed as prototypical secreted target proteins to evaluate the function of putative signal peptide peptidases (SppA and TepA) in Bacillus licheniformis. We observed dramatic decreases in the concentrations of both target proteins (45 and 49%, respectively) in a sppA deficient strain, while the extracellular protein yields of nattokinase and α-amylase were increased by 30 and 67% respectively in a strain overexpressing SppA. In addition, biomass, specific enzyme activities and the relative gene transcriptional levels were also enhanced due to the overexpression of sppA, while altering the expression levels of tepA had no effect on the concentrations of the secreted target proteins. Our results confirm that SppA, but not TepA, plays an important functional role for protein secretion in B. licheniformis. Our results indicate that the sppA overexpression strain, B. licheniformis BL10GS, could be used as a promising host strain for the industrial production of heterologous secreted proteins.

  5. First record and impact of the crown-of-thorns starfish, Acanthaster planci (Spinulosida: Acanthasteridae on corals of Malpelo Island, Colombian Pacific

    Directory of Open Access Journals (Sweden)

    Krupskaya Narváez

    2010-05-01

    Full Text Available The crown-of-thorns starfish, Acanthaster planci, is a major coral predator widely distributed in the Indo-Pacific region, where population outbreaks have caused dramatic impacts on coral reefs. In the Tropical Eastern Pacific (TEP A. planci occurs at low population densities; it has been significantly abundant only in Panama and Cocos Island. We have recently found two individuals of A. planci at Malpelo Island, a small oceanic island with significant coral communities located off the Colombian Pacific coast. The recent discovery of A. planci at Malpelo is significant in light of recent reports of its increased frequency of observation at Cocos Island and occurrence at the Galapagos Islands. The individuals found at Malpelo have been repeatedly sighted since 2004, actively feeding on nine species of coral. Although densities of A. planci are low at Malpelo and other oceanic islands of the TEP, these islands may act as stepping stones for the colonization of other coral reef areas in the region. However, the low densities of A. planci suggest that it currently poses no threat to coral reefs in the TEP. Rev. Biol. Trop. 58 (Suppl. 1: 139-143. Epub 2010 May 01.

  6. Morbid obesity and outcome of ectopic pregnancy following capped single-dose regimen methotrexate.

    Science.gov (United States)

    Hoyos, Luis R; Malik, Mokerrum; Najjar, Marvin; Rodriguez-Kovacs, Javier; Abdallah, Mazen; Vilchez, Gustavo; Awonuga, Awoniyi O

    2017-02-01

    Evaluate whether morbid obesity influenced resolution, number of doses or ultimately surgical management of tubal ectopic pregnancy (TEP) when treated with single-dose regimen methotrexate (SDR-MTX) capped at 100 mg. Retrospective cohort study of patients with a diagnosis of TEP who underwent MTX treatment from 2000 to 2013. Patients were excluded if initial β-hCG ectopic size, embryonic heart tones, decrease of β-hCG, need for additional MTX doses and surgery despite treatment were recorded and compared among the groups. 151 women were included in the study, 89.4% (135/151) non-morbidly obese and 10.6% (16/151) morbidly obese. No differences in age distribution, ethnicity, pre-treatment presence of embryonic heart tones, maximum diameter of ectopic size ≥35 mm and β-hCG ≥5000 mIU/ml were found. Following treatment, the proportion of patients with at least an 80% decrease in their β-hCG levels or need for surgery were similar, however, morbidly obese patients were significantly more likely [11/134 vs. 5/16, OR 5.1 (1.5-17.3, p = 0.015)] to require an additional MTX dose. Among patients with TEP, morbidly obese patients were five times more likely to require an additional dose compared to non-morbidly obese when SDR-MTX capped at 100 mg was used for medical management.

  7. Thermoelectric power of (Cu0.5Tl0.5)-1223 superconducting phase added with BaSnO3 nanoparticles

    Science.gov (United States)

    Srour, A.; Malaeb, W.; Marhaba, S.; Awad, R.

    2017-07-01

    In this study, we report the thermoelectric power (TEP) measurements of Cu0.5Tl0.5Ba2Ca2Cu3O10-δ added with BaSnO3 nanoparticles. BaSnO3 nanoparticles were prepared by chemical co-precipitation method, while (BaSnO3)x/(CuT1)-1223 superconducting samples with 0.00 ≤ x ≤ 1.50 wt% were prepared using the solid-state reaction method. The standard four-probe technique was applied to measure DC electrical resistivity in the temperature range from 300 to 77 K. Superconducting transition temperature (Tc) increases up to 117.5 for x = 0.25 wt.% and then it decreases with further x addition. The TEP coefficient was measured as a function of temperature in a wide temperature range from ∼77 K (liquid nitrogen temperature) up to 280 K using a standard differential technique. The behavior of the obtained TEP coefficient is suit with high-Tc copper-oxide superconductors. The results were investigated according to two-band model with an extra linear term. Several parameters such as the pseudo-gap temperature (T*), Fermi energy (EF) and Fermi temperature (TF) values were calculated and discussed in terms of nanoparticles BaSnO3 addition.

  8. Non destructive characterisation of RPV steel ageing parameters by thermoelectric power measurement

    Energy Technology Data Exchange (ETDEWEB)

    Delnondedieu, M.; Coste, J.F.; Van Duysen, J.C.; Jumel, S. [EDF R and D, Ecuelles, 77 - Moret-sur-Loing (France); Bache, A. [EDF GDL, 37 - AVOINE (France); Houze, M. [INSA de Lyon, GEMPPM, UMR (CNRS) 5510, 69 - Villeurbanne (France)

    2002-07-01

    The full text follows. The ageing of RPV (reactor pressure vessel) steels due to in service conditions (temperature, pressure and neutron irradiation) is followed by means of a specific surveillance programme composed of the analysis of samples set close to the core of the vessel by mechanical tests. The specimens of the surveillance programme are taken in one of the shell course that composes the vessel. Due to the forging of the shell course the mechanical characteristics of the RPV steel may be affected by microstructural heterogeneities. As a consequence, one of the major difficulty of the surveillance programme is to separate the effects of neutron irradiation on the mechanical characteristics from that related to the microstructural heterogeneities. In this context, non destructive methods are required to complete the surveillance programme. The measurement of thermoelectric power (TEP) seems sensitive to both neutron irradiation damage and evolution of forged component microstructure. This study undertakes the intermediate needed step of evaluating the sensitivity of TEP to the different parameters which have an influence on the aging of RPV steel: heat treatment, segregations, chemical composition and irradiation fluence. This step will lead to a better understanding of the results of a systematic measurement of TEP on actual programme surveillance samples. (authors)

  9. Prediction of Welding Deformation and Residual Stress of Stiffened Plates Based on Experiments

    Science.gov (United States)

    Bai, R. X.; Guo, Z. F.; Lei, Z. K.

    2017-12-01

    Thermo-elastic-plastic (TEP) method is a method that can accurately predict welding deformation and residual stresses, but the premise is to select the appropriate heat source parameters. Aiming at the two welded joints in the stiffened plate studied in this paper, the welding experiments of simple components were carried out respectively, and the corresponding welding deformation and residual stresses were measured. Based on the welding experiment, the corresponding TEP model was established, and the corresponding heat source parameters were obtained according to the experimental data. The comparison between the experimental results and the numerical results shows that the obtained heat source parameters can well predict the welding deformation and residual stress of the welded structure. And then, the obtained heat source parameters were applied to the TEP model of the stiffened plate. The prediction results show that the T-type fillet welds of the stiffened plate can reduce the angular deformation caused by the butt welds to a certain extent. In addition, we can also find that the heat of the subsequent welds can reduce the residual stresses at the completed welds. This method not only can save a lot of experimental costs and time, but also can accurately predict the welding deformation and residual stresses.

  10. TMSEEG: A MATLAB-Based Graphical User Interface for Processing Electrophysiological Signals during Transcranial Magnetic Stimulation.

    Science.gov (United States)

    Atluri, Sravya; Frehlich, Matthew; Mei, Ye; Garcia Dominguez, Luis; Rogasch, Nigel C; Wong, Willy; Daskalakis, Zafiris J; Farzan, Faranak

    2016-01-01

    Concurrent recording of electroencephalography (EEG) during transcranial magnetic stimulation (TMS) is an emerging and powerful tool for studying brain health and function. Despite a growing interest in adaptation of TMS-EEG across neuroscience disciplines, its widespread utility is limited by signal processing challenges. These challenges arise due to the nature of TMS and the sensitivity of EEG to artifacts that often mask TMS-evoked potentials (TEP)s. With an increase in the complexity of data processing methods and a growing interest in multi-site data integration, analysis of TMS-EEG data requires the development of a standardized method to recover TEPs from various sources of artifacts. This article introduces TMSEEG, an open-source MATLAB application comprised of multiple algorithms organized to facilitate a step-by-step procedure for TMS-EEG signal processing. Using a modular design and interactive graphical user interface (GUI), this toolbox aims to streamline TMS-EEG signal processing for both novice and experienced users. Specifically, TMSEEG provides: (i) targeted removal of TMS-induced and general EEG artifacts; (ii) a step-by-step modular workflow with flexibility to modify existing algorithms and add customized algorithms; (iii) a comprehensive display and quantification of artifacts; (iv) quality control check points with visual feedback of TEPs throughout the data processing workflow; and (v) capability to label and store a database of artifacts. In addition to these features, the software architecture of TMSEEG ensures minimal user effort in initial setup and configuration of parameters for each processing step. This is partly accomplished through a close integration with EEGLAB, a widely used open-source toolbox for EEG signal processing. In this article, we introduce TMSEEG, validate its features and demonstrate its application in extracting TEPs across several single- and multi-pulse TMS protocols. As the first open-source GUI-based pipeline

  11. TMSEEG: A MATLAB-Based Graphical User Interface for Processing Electrophysiological Signals during Transcranial Magnetic Stimulation

    Science.gov (United States)

    Atluri, Sravya; Frehlich, Matthew; Mei, Ye; Garcia Dominguez, Luis; Rogasch, Nigel C.; Wong, Willy; Daskalakis, Zafiris J.; Farzan, Faranak

    2016-01-01

    Concurrent recording of electroencephalography (EEG) during transcranial magnetic stimulation (TMS) is an emerging and powerful tool for studying brain health and function. Despite a growing interest in adaptation of TMS-EEG across neuroscience disciplines, its widespread utility is limited by signal processing challenges. These challenges arise due to the nature of TMS and the sensitivity of EEG to artifacts that often mask TMS-evoked potentials (TEP)s. With an increase in the complexity of data processing methods and a growing interest in multi-site data integration, analysis of TMS-EEG data requires the development of a standardized method to recover TEPs from various sources of artifacts. This article introduces TMSEEG, an open-source MATLAB application comprised of multiple algorithms organized to facilitate a step-by-step procedure for TMS-EEG signal processing. Using a modular design and interactive graphical user interface (GUI), this toolbox aims to streamline TMS-EEG signal processing for both novice and experienced users. Specifically, TMSEEG provides: (i) targeted removal of TMS-induced and general EEG artifacts; (ii) a step-by-step modular workflow with flexibility to modify existing algorithms and add customized algorithms; (iii) a comprehensive display and quantification of artifacts; (iv) quality control check points with visual feedback of TEPs throughout the data processing workflow; and (v) capability to label and store a database of artifacts. In addition to these features, the software architecture of TMSEEG ensures minimal user effort in initial setup and configuration of parameters for each processing step. This is partly accomplished through a close integration with EEGLAB, a widely used open-source toolbox for EEG signal processing. In this article, we introduce TMSEEG, validate its features and demonstrate its application in extracting TEPs across several single- and multi-pulse TMS protocols. As the first open-source GUI-based pipeline

  12. Tick Thioester-Containing Proteins and Phagocytosis Do Not Affect Transmission of Borrelia afzelii from the Competent Vector Ixodes ricinus

    Science.gov (United States)

    Urbanová, Veronika; Hajdušek, Ondřej; Hönig Mondeková, Helena; Šíma, Radek; Kopáček, Petr

    2017-01-01

    The present concept of the transmission of Lyme disease from Borrelia-infected Ixodes sp. ticks to the naïve host assumes that a low number of spirochetes that manage to penetrate the midgut epithelium migrate through the hemocoel to the salivary glands and subsequently infect the host with the aid of immunomodulatory compounds present in tick saliva. Therefore, humoral and/or cellular immune reactions within the tick hemocoel may play an important role in tick competence to act as a vector for borreliosis. To test this hypothesis we have examined complement-like reactions in the hemolymph of the hard tick Ixodes ricinus against Borrelia afzelii (the most common vector and causative agent of Lyme disease in Europe). We demonstrate that I. ricinus hemolymph does not exhibit borreliacidal effects comparable to complement-mediated lysis of bovine sera. However, after injection of B. afzelii into the tick hemocoel, the spirochetes were efficiently phagocytosed by tick hemocytes and this cellular defense was completely eliminated by pre-injection of latex beads. As tick thioester-containing proteins (T-TEPs) are components of the tick complement system, we performed RNAi-mediated silencing of all nine genes encoding individual T-TEPs followed by in vitro phagocytosis assays. Silencing of two molecules related to the C3 complement component (IrC3-2 and IrC3-3) significantly suppressed phagocytosis of B. afzelii, while knockdown of IrTep (insect type TEP) led to its stimulation. However, RNAi-mediated silencing of T-TEPs or elimination of phagocytosis by injection of latex beads in B. afzelii-infected I. ricinus nymphs had no obvious impact on the transmission of spirochetes to naïve mice, as determined by B. afzelii infection of murine tissues following tick infestation. This result supports the concept that Borrelia spirochetes are capable of avoiding complement-related reactions within the hemocoel of ticks competent to transmit Lyme disease. PMID:28361038

  13. Truck Essential Power Systems Efficiency Improvements for Medium-Duty Trucks

    Energy Technology Data Exchange (ETDEWEB)

    Larry Slone; Jeffrey Birkel

    2007-12-31

    With a variety of hybrid vehicles available in the passenger car market, electric technologies and components of that scale are becoming readily available. Commercial vehicle segments have lagged behind passenger car markets, leaving opportunities for component and system development. Escalating fuel prices impact all markets and provide motivation for OEMs, suppliers, customers, and end-users to seek new techniques and technologies to deliver reduced fuel consumption. The research presented here specifically targets the medium-duty (MD), Class 4-7, truck market with technologies aimed at reducing fuel consumption. These technologies could facilitate not only idle, but also parasitic load reductions. The development efforts here build upon the success of the More Electric Truck (MET) demonstration program at Caterpillar Inc. Employing a variety of electric accessories, the MET demonstrated the improvement seen with such technologies on a Class 8 truck. The Truck Essential Power Systems Efficiency Improvements for Medium-Duty Trucks (TEPS) team scaled the concepts and successes of MET to a MD chassis. The team designed an integrated starter/generator (ISG) package and energy storage system (ESS), explored ways to replace belt and gear-driven accessory systems, and developed supervisory control algorithms to direct the usage of the generated electricity and system behavior on the vehicle. All of these systems needed to fit within the footprint of a MD vehicle and be compatible with the existing conventional systems to the largest extent possible. The overall goal of this effort was to demonstrate a reduction in fuel consumption across the drive cycle, including during idle periods, through truck electrification. Furthermore, the team sought to evaluate the benefits of charging the energy storage system during vehicle braking. The vehicle features an array of electric accessories facilitating on-demand, variable actuation. Removal of these accessories from the belt or

  14. Effect of two different exercise regimens on trunk muscle morphometry and endurance in soldiers in training.

    Science.gov (United States)

    Teyhen, Deydre S; Childs, John D; Dugan, Jessica L; Wright, Alison C; Sorge, Joshua A; Mello, Jeremy L; Marmolejo, Michael G; Taylor, Adam Y; Wu, Samuel S; George, Steven Z

    2013-09-01

    Limited evidence exists on how strength and endurance exercises commonly used to prevent low back pain affect muscle morphometry and endurance. The purpose of this study was to analyze the effects of 2 exercise regimens on the morphometry and endurance of key trunk musculature in a healthy population. The study was designed as a randomized controlled trial. The study was conducted in a military training setting. A random subsample (n=340; 72% men, 28% women; mean [±SD] age=21.9±4.2 years; mean [±SD] body mass index=24.8±2.8 kg/m2) from the larger Prevention of Low Back Pain in the Military trial (N=4,325) was included. The core stabilization exercise program (CSEP) included low-load/low-repetition motor control exercises, whereas the traditional exercise program (TEP) included exercises conducted at a fast pace, with the use of high-load, high-repetition trunk strengthening exercises. Baseline and follow-up examinations included ultrasound imaging of the trunk muscles and endurance tests. Linear mixed models were fitted to study the group and time effect and their interactions, accounting for the clustering effect. Symmetry generally improved in the rest and contracted states, but there were no differences suggestive of muscle hypertrophy or improved ability to contract the trunk muscles between soldiers receiving the CSEP or the TEP. Total trunk endurance time decreased over the 12-week period, but endurance performance favored soldiers in the CSEP group. Endurance time was not associated with future episodes of low back pain. The lack of morphological changes may not be detectable in an already-active cohort, or a more intensive dose was needed. Although improved symmetry was noted, neither the CSEP nor the TEP resulted in muscle hypertrophy. Longer endurance times were noted in individuals who completed the CSEP but were not strongly predictive of future low back pain episodes.

  15. Prediction of environmental indices of Iran wheat production using artificial neural networks

    Energy Technology Data Exchange (ETDEWEB)

    Khoshnevisan, B.; Rafiee, Sh.; Omid, M.; Yousefi, M. [Department of Agricultural Machinery Engineering, Faculty of Agricultural Engineering and Technology, University of Tehran, Karaj (Iran, Islamic Republic of)

    2013-07-01

    This study was carried out in the province of Esfahan in Iran in order to model field emissions of wheat production, using artificial neural networks (ANNs). Data were collected from 260 wheat farms in Fereydonshahr city with face to face questionnaire method. Life cycle assessment (LCA) methodology was developed to assess all the environmental impacts associated with wheat cultivation in the studied region. Global warming potential (GWP), eutrophication potential (EP), human toxicity potential (HTP), terrestrial ecotoxicity potential (TEP), oxidant formation potential (OFP) and acidification potential (AP) were chosen as target outputs. System boundary and functional unite were selected farm gate and one ton of wheat grain. All input energies and farm size were selected as inputs and six impact categories were chosen as outputs of the model. To find the best topology, several ANN models with different number of hidden layers and neurons in each layer were developed. Subsequently, we applied different activation functions in each hidden layer to assess the best performance with highest coefficient of determination (R2), lowest root mean square error (RMSE) and mean absolute error (MAE). Accordingly, ANN model with 12-6-6-6 structure showed the best performance. RMSE for GWP, HTP, EP, OFP, AP and TEP were 45.82, 6.22, 7.47, 0.96, 0.28 and 0.09, respectively. Also, MAEs for this model were 14.9, 0.77, 1.5, 0.02, 0.14 and 0.02 for GWP, HTP, EP, OFP, AP and TEP.

  16. Infiltration of wounds and extraperitoneal space with local anesthetic in patients undergoing laparoscopic totally extraperitoneal repair of unilateral inguinal hernias: a randomized double-blind placebo-controlled trial.

    Science.gov (United States)

    Abbas, M H; Hamade, A; Choudhry, M N; Hamza, N; Nadeem, R; Ammori, B J

    2010-01-01

    The potential analgesic benefit of infiltration of the wounds and extraperitoneal space with local anesthetic in patients undergoing laparoscopic totally extraperitoneal (TEP) repair of inguinal hernias remains unclear. Consenting adults scheduled to undergo laparoscopic TEP repair of unilateral inguinal hernias were recruited to this randomized double-blind placebo-controlled clinical trial of 0.25% bupivacaine (Group I) versus saline (Group II) infiltration of abdominal wounds and the extraperitoneal space. Pain scores were assessed at 4 and 24 hours postoperatively using the short-form McGill pain questionnaire (SF-MPQ), the Present Pain Index (PPI) score and the visual analogue scale (VAS). The intravenous and oral analgesic requirements were recorded. Each patient completed questionnaire to assess their satisfaction with the postoperative analgesia. 40 patients were randomized (Group I, n = 20; Group II, n = 20). The two groups were comparable for age, gender, body mass index, and operating time. Minor complications occurred in one patient in each group. There were no significant differences in the postoperative SF-MPQ scores, PPI and VAS at 4 hours (p = 0.413, p = 0.631, p = 0.615 respectively) and 24 hours (p = 0.116, p = 0.310, p = 0.100 respectively) post-operatively. The parenteral and oral analgesics consumed post-surgery were comparable (p = 0.605, p = 0.235). No difference was ob-served in the patient satisfaction scores. Infiltration of abdominal wounds and extraperitoneal space with bupivacaine in patients undergoing laparoscopic TEP repair of unilateral inguinal hernias does not appear to offer analgesic benefits.Key words: Laparoscopic; extraperitoneal; inguinal hernia; repair; pain; bupivacaine; analgesia; satisfaction; day case; randomized.

  17. Research paper no. 18. Trading rules for CO{sub 2} emission permits systems. A proposal for ceilings on quantities and prices; Cahier de recherche no. 18. Regulation des marches de droits d'emission negociables pour le CO{sub 2}. Une proposition de plafonds pour les quantites et pour les prix

    Energy Technology Data Exchange (ETDEWEB)

    Criqui, P.; Viguier, L

    2000-01-01

    Tradable emission permit (TEP) systems for greenhouse gases (GHGs) as they could develop following the Kyoto Protocol - that is if they are limited to Annex B countries and are not bound by exchange regulations - do not appear to be greatly acceptable today, either to the United States or to the European Union. The problem of the uncertainty related to the cost of reducing emissions is strongly highlighted in the United States: in fact, the approach adopted in the Kyoto Protocol, that of quantitative emissions targets, leaves the question of the reduction programme costs wide open. For the European Union, the unregulated TEP system is hardly acceptable because it would not guarantee that the principle of 'supplementarity' adopted in the Kyoto Protocol, that is, the fact that the purchase of permits should be in addition to action taken within each of the Annex B countries. The section two of this paper is an in-depth economic analysis of the european proposal for ''concrete ceilings''. The alternative proposals, formulated in the United States and relating more to permit price ceilings or''trigger price'', are examined in Section 3. After showing that each of the foregoing proposals could have consequences unacceptable to some or others of the parties to the Protocol, Section 4 offers the proposal of a hybrid formula for regulating the rights market. In fact, the main aim of this paper is to show that the implementation of a 'hybrid solution', consisting of limiting the volume of exchanges while at the same time introducing a TEP price ceiling, could provide a market regulation framework effect allowing the benefits of most of the economic advantages to be enjoyed and also having characteristics acceptable to the various parties from an environmental as well as from an international fairness point of view. (A.L.B.)

  18. Research paper no. 18. Trading rules for CO2 emission permits systems. A proposal for ceilings on quantities and prices

    International Nuclear Information System (INIS)

    Criqui, P.; Viguier, L.

    2000-01-01

    Tradable emission permit (TEP) systems for greenhouse gases (GHGs) as they could develop following the Kyoto Protocol - that is if they are limited to Annex B countries and are not bound by exchange regulations) - do not appear to be greatly acceptable today, either to the United States or to the European Union. The problem of the uncertainty related to the cost of reducing emissions is strongly highlighted in the United States: in fact, the approach adopted in the Kyoto Protocol, that of quantitative emissions targets, leaves the question of the reduction programme costs wide open. For the European Union, the unregulated TEP system is hardly acceptable because it would not guarantee that the principle of 'supplementarity' adopted in the Kyoto Protocol, that is, the fact that the purchase of permits should be in addition to action taken within each of the Annex B countries. The section two of this paper is an in-depth economic analysis of the european proposal for ''concrete ceilings''. The alternative proposals, formulated in the United States and relating more to permit price ceilings or''trigger price'', are examined in Section 3. After showing that each of the foregoing proposals could have consequences unacceptable to some or others of the parties to the Protocol, Section 4 offers the proposal of a hybrid formula for regulating the rights market. In fact, the main aim of this paper is to show that the implementation of a 'hybrid solution', consisting of limiting the volume of exchanges while at the same time introducing a TEP price ceiling, could provide a market regulation framework effect allowing the benefits of most of the economic advantages to be enjoyed and also having characteristics acceptable to the various parties from an environmental as well as from an international fairness point of view. (A.L.B.)

  19. Eficacia de un programa de intervención individual y breve para el trastorno por estrés postraumático en mujeres víctimas de violencia doméstica

    Directory of Open Access Journals (Sweden)

    Francisco Javier Labrador

    2006-01-01

    Full Text Available El objetivo del presente estudio es determinar la eficacia de un programa de tratamiento breve del trastorno por estrés postraumático (TEP en mujeres víctimas de violencia doméstica. La muestra estuvo constituida por 20 participantes, todas cumplían los criterios DSM-IV-TR para el diagnóstico de TEP, constituyendo 10 el grupo de control de lista de espera y 10 el grupo de tratamiento. El programa de tratamiento, derivado del de Labrador y Rincón, se aplicó de forma individual y constaba de 8 sesiones (2 meses, siendo sus componentes fundamentales la psicoeducación, técnicas de desactivación, terapia cognitiva y terapia de exposición. Se utilizó un diseño cuasiexperimental con dos grupos independientes de medidas repetidas (en el pretratamiento y en el postratamiento. Los resultados en el postratamiento indican que el programa fue efectivo para la reducción del TEP en el 100% de los casos. Se produjo además una mejora significativa en otras variables concomitantes: depresión, autoestima, inadaptación y cogniciones postraumáticas. No se encontraron, sin embargo, diferencias significativas en función de que se alterara el orden de aplicación de la terapia cognitiva y la terapia de exposición. Se discuten las implicaciones de este estudio para la práctica clínica y futuras investigaciones.

  20. Long-latency TMS-evoked potentials during motor execution and inhibition

    Directory of Open Access Journals (Sweden)

    Kentaro eYamanaka

    2013-11-01

    Full Text Available Transcranial magnetic stimulation (TMS has often been used in conjunction with electroencephalography (EEG, which is effective for the direct demonstration of cortical reactivity and corticocortical connectivity during cognitive tasks through the spatio-temporal pattern of long-latency TMS-evoked potentials (TEPs. However, it remains unclear what pattern is associated with the inhibition of a planned motor response. Therefore, we performed TMS-EEG recording during a go/stop task, in which participants were instructed to click a computer mouse with a right index finger when an indicator that was moving with a constant velocity reached a target (go trial or to avoid the click when the indicator randomly stopped just before it reached the target (stop trial. Single-pulse TMS to the left (contralateral or right (ipsilateral motor cortex was applied 500 ms before or just at the target time. TEPs related to motor execution and inhibition were obtained by subtractions between averaged EEG waveforms with and without TMS. As a result, in TEPs induced by both contralateral and ipsilateral TMS, small oscillations were followed by a prominent negative deflection around the TMS site peaking at approximately 100 ms post-TMS (N100, and a less pronounced later positive component (LPC over the broad areas that was centered at the midline-central site in both go and stop trials. However, compared to the pattern in go and stop trials with TMS at 500 ms before the target time, N100 and LPC were differently modulated in the go and stop trials with TMS just at the target time. The amplitudes of both N100 and LPC decreased in go trials, while the amplitude of LPC decreased and the latency of LPC was delayed in both go and stop trials. These results suggested that TMS-induced neuronal reactions in the motor cortex and subsequent their propagation to surrounding cortical areas might change functionally according to task demand when executing and inhibiting a motor

  1. Identifying inequitable exposure to toxic air pollution in racialized and low-income neighbourhoods to support pollution prevention

    Directory of Open Access Journals (Sweden)

    Suzanne Kershaw

    2013-05-01

    Full Text Available Numerous environmental justice studies have confirmed a relationship between population characteristics such as low-income or minority status and the location of environmental health hazards. However, studies of the health risks from exposure to harmful substances often do not consider their toxicological characteristics. We used two different methods, the unit-hazard and the distance-based approach, to evaluate demographic and socio-economic characteristics of the population residing near industrial facilities in the City of Toronto, Canada. In addition to the mass of air emissions obtained from the national pollutant release inventory (NPRI, we also considered their toxicity using toxic equivalency potential (TEP scores. Results from the unit-hazard approach indicate no significant difference in the proportion of low-income individuals living in host versus non-host census tracts (t(107 = 0.3, P = 0.735. However, using the distance-based approach, the proportion of low-income individuals was significantly higher (+5.1%, t(522 = 6.0, P <0.001 in host tracts, while the indicator for “racialized” communities (“visible minority” was 16.1% greater (t(521 = 7.2, P <0.001 within 2 km of a NPRI facility. When the most toxic facilities by non-carcinogenic TEP score were selected, the rate of visible minorities living near the most toxic NPRI facilities was significantly higher (+12.9%, t(352 = 3.5, P = 0.001 than near all other NPRI facilities. TEP scores were also used to identify areas in Toronto that face a double burden of poverty and air toxics exposure in order to prioritise pollution prevention.

  2. Avaliação do ventrículo direito pelo ecocardiograma com doppler tecidual na embolia pulmonar aguda

    Directory of Open Access Journals (Sweden)

    Ana Clara Tude Rodrigues

    2013-06-01

    Full Text Available FUNDAMENTO: A avaliação da função Ventricular Direita (VD pelo ecocardiograma em pacientes com Tromboembolismo Pulmonar (TEP é complexa, frequentemente qualitativa; o Doppler tecidual tem sido utilizado para avaliação semiquantitativa dessa câmara, com algumas limitações. OBJETIVO: Avaliar a função do VD no TEP pelo ecocardiograma com Doppler tecidual, complementando com o peptídeo atrial natriurético (BNP. MÉTODOS: Foram estudados pacientes com TEP pelo ecocardiograma com Doppler tecidual e BNP até 24 horas do diagnóstico, obtendo-se as velocidades miocárdicas (s', strain, strain rate e índice de performance miocárdica do VD; disfunção do VD foi iagnosticada por hipocinesia da câmara, movimento anormal septal e relação VD/VE >1. De acordo com o BNP os pacientes foram divididos em Grupo I, BNP 50 pg/mL. RESULTADOS: De 118 pacientes, 100 (60 homens, idade = 55 ± 17 anos foram analisados; observou-se disfunção do VD em 28%, mais frequentemente no grupo II (19 vs. 9 pacientes, p < 0,001. O grupo II era mais idoso (64 ± 19 vs. 50 ± 15 anos, apresentava menor velocidade de s' (10,5 ± 3,5 vs. 13,2 ± 3,1 cm/s e maior pressão pulmonar (48 ± 11 vs. 35 ± 11 mmHg, p < 0,001 para todos. O ponto de corte de s' para disfunção do VD foi de 10,8 cm/s (especificidade = 85%, sensibilidade = 54%, com moderada correlação entre o BNP e a onda s'(r = -0,39. CONCLUSÃO: No TEP, a disfunção do VD pelo ecocardiograma se acompanha de elevação do BNP; apesar confirmar adequadamente a presença de disfunção do VD, o Doppler tecidual apresenta sensibilidade limitada para este diagnóstico.

  3. In the field of energy cost reduction, what is the potential?; En matiere de reduction des depenses d`energie: quel est le gisement?

    Energy Technology Data Exchange (ETDEWEB)

    Millet, B. [Departement Industrie, CEREN (France)

    1996-12-31

    Through a segmentation of the fuel and electric power consumptions in the various industrial sectors and energy consumption process types in France in 1990, the energy conservation potential in the French metalworking and mechanical industry is analyzed and its evolution up to 2005 is assessed. It is shown that the reduction potential amounts to 450 kTep or 20 percent of the metalworking and metallic construction industry energy consumption, with an important part for the out-of-process sector (space heating, compressed air production, lighting). In the process sector, important reductions could be realized in thermal treatments and metal heating prior forming

  4. Project W-314 specific test and evaluation plan for 241-AY-01A pump pit upgrade

    International Nuclear Information System (INIS)

    Hays, W.H.

    1998-01-01

    This Specific Test and Evaluation Plan (STEP) defines the test and evaluation activities encompassing the upgrade of the 241-AY-0IA Pump Pit for the W-314 Project. The purpose of this Specific Test and Evaluation Plan (STEP) is to provide a detailed written plan for the systematic testing of modifications made to the 241-AY-01A Pump Pit by the W-314 Project. The STEP develops the outline for test procedures that verify the system's performance to the established Project design criteria. The STEP is a lower tier document based on the W-314 Test and Evaluation Plan (TEP)

  5. Compliance Testing of Grissom Air Force Base Central Heating Plant Coal- Fired Boilers 3, 4, and 5, Grissom Air Force Base, Indiana

    Science.gov (United States)

    1992-06-01

    92P[H’, RUN U METER BOX ’? METER 80;: l -, METER BG Y’ .40 RH -. 8840 P: 1. 8840 P !;!’ DELTA H? DELTP H’ DELTA H" - --- RUEI BAPR PRESS BAR FFE: Bpp ...I29.339:)0 PI.I 29.3-330 RIJi 2%’ 3798 RL.’I METER ’OL LMEE ? METER YOL ") ~ j4 C P1k .. ...7620 RUI MTR TEMP F? MTR TEMP F7 MTR TE.P F? 48.0800 P111

  6. Repair of inguinal hernia: a comparison between extraperitoneal laparoscopy and Lichtenstein open surgery

    Directory of Open Access Journals (Sweden)

    Tavassoli A

    2010-06-01

    Full Text Available "n Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Background: The inguinal hernia is a common disorder in general surgery. Different methods have been described for repair of these hernias. In modern methods, synthetic mesh is used to cover the wall defect and the most known method is Lichtenstein surgical repair. The laparoscopic totally extra peritoneal procedure (TEP is a newer technique of repairing hernia. The aim of this study is to compare the outcomes of totally extraperitoneal laparoscopic inguinal hernia repair versus Lichtenstein open repair in patients with inguinal hernia."n"nMethods: Among 50 patients, 25 cases underwent Lichtenstein procedure and 25 patients underwent TEP technique for repairing primary unilateral inguinal hernia. Findings during the operation have been recorded and the 12-months follow-up of patients in different views was performed through a questionnaire and then the results were compared."n"nResults: The operation duration, the rate of complications and frequency of recurrence were similar in two groups; but the hospital stay, postoperative pain, chronic groin pain and the required time to return to normal activity were significantly lower in patients who underwent the TEP method compared to the patients who underwent the

  7. TMSEEG: A MATLAB-Based Graphical User Interface for Processing Electrophysiological Signals during Transcranial Magnetic Stimulation

    Directory of Open Access Journals (Sweden)

    Sravya Atluri

    2016-10-01

    Full Text Available Concurrent recording of electroencephalography (EEG during transcranial magnetic stimulation (TMS is an emerging and powerful tool for studying brain health and function. Despite a growing interest in adaptation of TMS-EEG across neuroscience disciplines, its wide-spread utility is limited by signal processing challenges. These challenges arise due to the nature of TMS and the sensitivity of EEG to artifacts that often mask TMS-evoked potentials (TEPs. With an increase in the complexity of data processing methods and a growing interest in multi-site data integration, analysis of TMS-EEG data requires the development of a standardized method to recover TEPs from various sources of artifacts. This paper introduces TMSEEG, an open-source MATLAB application comprised of multiple algorithms organized to facilitate a step-by-step procedure for TMS-EEG signal processing. Using a modular design and interactive GUIs, this toolbox aims to streamline TMS-EEG signal processing for both novice and experienced users. Specifically, TMSEEG provides (i targeted removal of TMS-induced and general EEG artifacts, (ii a step-by-step modular workflow with flexibility to modify existing algorithms and add customized algorithms, (iii a comprehensive display and quantification of artifacts, (iv quality control check points with visual feedback of TEPs throughout the data processing workflow, and (v capability to label and store a database of artifacts. In addition to these features, the software architecture of TMSEEG ensures minimal user effort in initial setup and configuration of parameters for each processing step. This is partly accomplished through a close integration with EEGLAB, a widely used open-source toolbox for EEG signal processing. In this paper we introduce TMSEEG, validate its features, and demonstrate its application in extracting TEPs across several single- and multi-pulse TMS protocols. As the first open-source GUI-based pipeline for TMS-EEG signal

  8. RECIFE: NOTES AROUND THE GENESIS OF A FIELD CULTURAL

    Directory of Open Access Journals (Sweden)

    Flávio Weinstein Teixeira

    2014-12-01

    Full Text Available Regard to the discussion of artistic modernity in Brazil, the article presents a panel of intellectual and cultural debates in Recife (1920-50, in order to give weight to the power lines, literate sociability, as well as the spaces of recognition and consecration the artistic/intellectual making that resulted in a specific dynamic to the cultural field of the city. Therefore, give special attention to the actions of a local theater group (TEP – Pernambuco Students’s Theatre and their contribution to the renewal of artistic and intellectual practices.

  9. (Re)Programa, Rehabilitación Arquitectónica con criterios de sostenibilidad de un barrio en Andalucía

    OpenAIRE

    Blandón González, Begoña; Gómez de Terreros Guardiola, Pedro; Barrios Padura, Ángela; Molina Huelva, Marta; Mercader-Moyano, Pilar (Coordinador)

    2017-01-01

    Entre los años 2013 a 2015, miembros del grupo TEP 954 InFact trabajaron en el contrato I+D adjudicado por la Agencia de Obra Pública de la Junta de Andalucía, estudiando las necesidades de intervención en el parque edificado andaluz construido desde los años 40 con el objetivo de garantizar el “envejecimiento activo” y “en casa”. Se propone un nuevo modelo urbano que garantiza que las personas puedan permanecer en sus barrios hasta el final de sus días, desde proyectos cent...

  10. In vitro ruminal fermentation and methane production of different seaweed species

    DEFF Research Database (Denmark)

    Molina-Alcaide, E.; Carro, M.D.; Roleda, M. Y.

    2017-01-01

    Seaweeds have potentials as alternative feed for ruminants, but there is a limited knowledge on their nutritive value. Seven seaweed species collected along the coast above the Arctic circle of Norway, both in spring and autumn, were assessed for nutrients and total polyphenols (TEP) content, gas...... production kinetics and in vitro rumen fermentation in batch cultures of ruminal microorganisms. The seaweeds were three red species (Mastocarpus stellatus, Palmaria palmata and Porphyra sp.), three brown species (Alaria esculenta, Laminaria digitata and Pelvetia canaliculata) and one green species...

  11. A comparison of the resistance of Temporary Edge Protection Systems to static and dynamic loads

    Directory of Open Access Journals (Sweden)

    González, M. N.

    2015-06-01

    Full Text Available Temporary Edge Protection Systems (TEPS are designed to withstand the impact of a worker that walks, stumbles, and falls against them. This is by nature a dynamic action; however, many standards evaluate TEPS when the surface or slope is slightly inclined (less than 10°, applying static requirements. The performance requirements demanded by these standards are assumed to be equivalent to the impact of a worker, however this point has not been tested. In this study, TEPS with tubular steel guardrails and wooden boards of different quality under two types of loads are evaluated using the static requirements detailed in standard EN 13374. TEPS are subjected to an impact energy of 180 J, simulating a worker of 90 kg walking at a speed of 2 m/s. The results demonstrate that the static requirements of EN 13374 are more demanding than the impact of 180 J in all the systems under study.Los sistemas provisionales de protección de borde (SPPB están diseñados para detener el impacto de un trabajador que camina, tropieza y golpea contra ellas. Esto supone una acción de naturaleza dinámica. Sin embargo, muchas normas evalúan SPPB utilizando requisitos de tipo estático cuando la superficie de trabajo está poco inclinada (menos de 10° suponiendo que equivalen al impacto de un trabajador. No obstante, este aspecto no se ha confirmado experimentalmente. En este trabajo SPPB con barandillas de tubos de acero y de tablas de madera se han evaluado usando los requisitos estáticos definidos por la norma EN 13374. Posteriormente, se han sometido a una energía de impacto de 180 J, que simula a un trabajador de 90 kg caminando a una velocidad de 2 m/s. Los resultados demuestran que los requisitos estáticos de la norma EN 13374 son más exigentes que el impacto de 180 J en todos los sistemas estudiados.

  12. CO{sub 2} intensity in electricity delivered to Swiss end-users. Summary report; Intensite CO{sub 2} de l'electricite vendue aux consommateurs finaux en Suisse. Resume du rapport final

    Energy Technology Data Exchange (ETDEWEB)

    Jakob, M.; Volkart, K.; Widmer, D

    2009-07-15

    In this short summary report published by TEP Energy GmbH in Zuerich the main findings of a study made for the Swiss gas and oil industries on the effective CO{sub 2} intensities involved in Swiss electricity consumption are presented and discussed. The authors present their ideas on how CO{sub 2} emissions should be calculated on the basis of figures on Swiss power generation, imports and exports in a European context. The results obtained from the use of three methods for viewing Swiss electricity consumption involving net and gross power export and import are briefly discussed.

  13. GRED III Final Report Clifton Hot Springs Geothermal Greenlee County, AZ

    Energy Technology Data Exchange (ETDEWEB)

    Brown, David E.

    2006-06-15

    Black & Veatch Corporation has prepared this report for Arizona Public Service Company, Salt River Project, and Tucson Electric Power Company (APS/SRP/TEP). The purpose of this report is to assess the prospects for significant renewable energy development in Arizona. The scope of the study is limited to Arizona projects that would export power to the grid (that is, not distributed energy projects). This study includes a review of the current status of renewable energy in Arizona, characterization of renewable power generation technologies, assessment of Arizona''s renewable resources, and an assessment of key risk factors. This section summarizes the key findings in these areas.

  14. The Temporary Environment - Cold Regions Habitability

    Science.gov (United States)

    1976-10-01

    groups. Usually six categories of.iges are used: Infants (under 2 )earsh. pmeschool (2 to 5 years. i I monAN pretms (6 to I I years. I I miondis). teps I...these groups. Table Bi: Twie spent in the house by children and adolescents. Infants (under 2) Prelchnol (2-51 oung School NW- N=6 N--13 N=O N=S boys...that they refused to var one. The gloves and/or arctic mittens were the next most criticized item (26.9%). The two complaints were. I) that they simply

  15. Aspiration of tracheoesophageal prosthesis in a laryngectomized patient

    Directory of Open Access Journals (Sweden)

    Conte Sergio C

    2012-08-01

    Full Text Available Abstract Background The voice prosthesis inserted into a tracheoesophageal fistula has become the most widely used device for voice rehabilitation in patients with total laryngectomy. Case presentation We describe a case of tracheoesophageal prosthesis’ (TEP aspiration in a laryngectomized patient, with permanent tracheal stoma, that appeared during standard cleaning procedure, despite a programme of training for the safe management of patients with voice prosthesis. Conclusions The definitive diagnosis and treatment were performed by flexible bronchoscopy, that may be considered the procedure of choice in these cases, also on the basis of the literature.

  16. Posibilidad de aprovechamiento de residuos textiles para la obtención de etanol

    OpenAIRE

    Zurima Menéndez-Ramírez; Azam Jeihanipour; Mohammad Taherzadeh; Lourdes Zumalacárregui-de Cárdenas

    2010-01-01

    El uso del bioetanol como combustible es una alternativa para minimizar los efectos negativos al medioambiente, ya que reduce el efecto invernadero. En este trabajo se estudian residuos textiles como candidatos para la producción de etanol. Los residuos textiles pretratados con NaOH 12 % (p/v) 0 °C, 3 h (TEP) y sin pretratar (TESP y TDSP), fueron sometidos a procesos simultáneos de sacarificación y fermentación (37 °C, 145 r/min, pH 4,8 a 5). Durante la sacarificación y fermentación, la veloc...

  17. O Reflexo das Atividades Práticas no Processo Ensino-Aprendizagem das Técnicas de Exame Psicológico

    OpenAIRE

    Lima, Ricardo Alves de

    2009-01-01

    O presente estudo teve como objetivo investigar o reflexo das atividades práticas no processo ensino-aprendizagem das técnicas de exame psicológico (T.E.P.), mais especificamente dos testes do Desenho da Figura Humana (DFH), Desenho da Família, Psicodiagnóstico Miocinético (PMK), Psicodiagnóstico de Rorschach e o Teste de Apercepção Temática (T.A.T.). Pode-se observar, em síntese, que as atividades práticas exigem e preocupam o aluno, por vezes, de maneira excessiva, prejudicando assim seu ap...

  18. An Overview of Governance and Accountability of Tahfiz Institutions in Malaysian: Religious Councils Perspective

    Directory of Open Access Journals (Sweden)

    Bani Hamidah

    2017-01-01

    Full Text Available Tahfiz education is one of the popular streams of education in Malaysia and well accepted by Muslim community. Originally the education is being offered in “pondok”, a traditional religious school. Developing through times, it is now also being offered in tahfiz centers as well as in modern tahfiz institutions. These entities specialize in producing tahfiz graduates who can memorize and recite the whole Al-Quran and more than 91% of them are privately owned. The applicability of good governance and accountability measures is indeed highly desirable in these Islamic entities as it deals with the responsibility in fulfilling sacred religious obligation. Though the number of tahfiz education providers (TEP has grown up tremendously from only 58 in 1999 to 278 in 2011, literatures on governance and accountability of TEP are still lacking as the areas are rarely examined directly. The lacking may lead to unfavorable inferences that TEP are behaving in the manners contrary to the interest of the stakeholders. An ideally accountable governance of tahfiz centers will gain trust from parents and various stakeholders and will indicate the achievement in fulfilling one of the objective of Maqasid Shariah to preserve and promote the religious faith through preserving the memorization and knowledge of Al Quran (the primary source of Islamic Law by the huffaz. The objective of this research is to investigate external governance mechanism and the accountability of Tahfiz centers as viewed by religious regulatory bodies. A qualitative research approach is undertaken by interviewing representatives from selected State Islamic Religious Councils, State Islamic Foundation and National Religious Departments in Malaysia. Using thematic analysis, findings of this study revealed that there are two-tier governance infrastructures of tahfiz institutions in Malaysia. However, the enforcement of the governance structure is still at infancy level. The accountability

  19. Project W-314 specific test and evaluation plan for 241-AY-02A pump pit upgrade

    International Nuclear Information System (INIS)

    Hays, W.H.

    1998-01-01

    This Specific Test and Evaluation Plan (STEP) defines the test and evaluation activities encompassing the upgrade of the 241-AY-02A Pump Pit for the W-314 Project. The purpose of this Specific Test and Evaluation Plan (STEP) is to provide a detailed written plan for the systematic testing of modifications made to the 241-AY-02A Pump Pit by the W-314 Project. The STEP develops the outline for test procedures that verify the system's performance to the established Project design criteria. The STEP is a lower tier document based on the W-314 Test and Evaluation Plan (TEP)

  20. Sol-Gel SiO2-CaO-P2O5 biofilm with surface engineered for medical application

    Directory of Open Access Journals (Sweden)

    Sonia Regina Federman

    2007-06-01

    Full Text Available Sol-gel film in the SiO2-CaO-P2O5 system was prepared from TEOS, TEP, alcohol and hydrated calcium nitrate in an acidic medium. The coatings were deposited on stainless steel using the dip-coating technique. After deposition, the composite was submitted to heat treatment, at different temperatures and exposure times to investigate the influence of such parameters on the surface morphology of the composite. The coated surfaces were characterized by AFM, SEM and FTIR. The present study showed that the formation of different textures (an important parameter in implant fixation could be controlled by temperature and time of heat treatment.

  1. Predominant constitutive CFTR conductance in small airways

    Directory of Open Access Journals (Sweden)

    Lytle Christian

    2005-01-01

    Full Text Available Abstract Background The pathological hallmarks of chronic obstructive pulmonary disease (COPD are inflammation of the small airways (bronchiolitis and destruction of lung parenchyma (emphysema. These forms of disease arise from chronic prolonged infections, which are usually never present in the normal lung. Despite the fact that primary hygiene and defense of the airways presumably requires a well controlled fluid environment on the surface of the bronchiolar airway, very little is known of the fluid and electrolyte transport properties of airways of less than a few mm diameter. Methods We introduce a novel approach to examine some of these properties in a preparation of minimally traumatized porcine bronchioles of about 1 mm diameter by microperfusing the intact bronchiole. Results In bilateral isotonic NaCl Ringer solutions, the spontaneous transepithelial potential (TEP; lumen to bath of the bronchiole was small (mean ± sem: -3 ± 1 mV; n = 25, but when gluconate replaced luminal Cl-, the bionic Cl- diffusion potentials (-58 ± 3 mV; n = 25 were as large as -90 mV. TEP diffusion potentials from 2:1 NaCl dilution showed that epithelial Cl- permeability was at least 5 times greater than Na+ permeability. The anion selectivity sequence was similar to that of CFTR. The bionic TEP became more electronegative with stimulation by luminal forskolin (5 μM+IBMX (100 μM, ATP (100 μM, or adenosine (100 μM, but not by ionomycin. The TEP was partially inhibited by NPPB (100 μM, GlyH-101* (5–50 μM, and CFTRInh-172* (5 μM. RT-PCR gave identifying products for CFTR, α-, β-, and γ-ENaC and NKCC1. Antibodies to CFTR localized specifically to the epithelial cells lining the lumen of the small airways. Conclusion These results indicate that the small airway of the pig is characterized by a constitutively active Cl- conductance that is most likely due to CFTR.

  2. Growth and Characterization of Tl2S Single Crystals

    Science.gov (United States)

    Gamal, G. A.; Zied, M. Abou; Gerges, M. K.; Galal, E. M.

    2003-09-01

    Single crystals of the Tl2S compound were grown for the first time in our laboratory by a new crystal growth technique based on a modification of the traveling heater method technique (THM). This growth was performed in our laboratory. Electrical conductivity, Hall effect and thermoelectric power (TEP) measurements were carried out in the temperature range (200-575 K). Throughout these measurements, various physical parameters such as effective mass of charge carriers, carrier mobility, diffusion length, diffusion coefficient, and the relaxation time for both majority and minority carriers were found. In conjunction with electrical conductivity and charge carrier concentration, thermoelectric power is discussed.

  3. Ceramic Membrane combined with Powdered Activated Carbon (PAC) or Coagulation for Treatment of Impaired Quality Waters

    KAUST Repository

    Hamad, Juma Z.

    2013-08-29

    Ceramic membranes (CM) are robust membranes attributed with high production, long life span and stability against critical conditions. While capital costs are high, these are partially offset by lower operation and maintenance costs compared to polymeric membranes. Like any other low-pressure membrane (LPM), CM faces problems of fouling, low removal of organic matter and poor removal of trace organic compounds (TOrCs). Current pretreatment approaches that are mainly based on coagulation and adsorption can remove some organic matter but with a low removal of the biopolymers component which is responsible for fouling. Powdered activated carbon (PAC) accompanied with a LPM maintains good removal of TOrCs. However, enhanced removal of TOrCs to higher level is required. Submicron powdered activated carbon (SPAC), obtained after crushing commercial activated carbon into very fine particle, and novel activated carbon (KCU 6) which is characterized with larger pores and high surface area were employed. A pre-coating approach, which provides intimated contact between PAC and contaminants, was adopted for wastewater and (high DOC) surface water treatment. For seawater, in-line coagulation with iron III chloride was adopted. Both SPAC and KCU 6 showed good removal of biopolymers at a dose of 30 mg/L with > 85 % and 90 %, respectively. A dose of 40 mg/L of SPAC and 30 mg/L KCU 6 pre-coats were successful used in controlling membrane fouling. SPAC is suggested to remove biopolymers by physical means and adsorption while KCU 6 removed biopolymers through adsorption. Both KCU 6 and SPAC attained high removal of TOrCs whereas KCU 6 showed outstanding performance. Out of 29 TOrCs investigated, KCU 6 showed > 87 % TOrCs rejection for 28 compounds. In seawater pretreatment, transparent exopolymer particles (TEP) were found to be an important foulant. TEP promoted both reversible and irreversible fouling. TEP are highly electronegative while alumina CM is positively charged which

  4. Organic Carbon Reduction in Seawater Reverse Osmosis (SWRO) Plants, Jeddah, Saudi Arabia

    KAUST Repository

    Alshahri, Abdullah

    2015-12-01

    Desalination is considered to be a major source of usable water in the Middle East, especially the Gulf countries which lack fresh water resources. A key and sometimes the only solution to produce high quality water in these countries is through the use of seawater reverse osmosis (SWRO) desalination technology. Membrane fouling is an economic and operational defect that impacts the performance of SWRO desalination technology. To limit this fouling phenomenon, it is important to implement the appropriate type of intake and pre-treatment system design. In this study, two types of systems were investigated, a vertical well system and a surface-water intake at a 9m depth. The purpose of this investigation is to study the impact of the different intake systems and pre-treatment stages in minimizing the concentrations of algae, bacteria, natural organic matter (NOM) and transparent exopolymer particles (TEP), in the feed water prior to pre-treatment, through the pre-treatment stages, and in the product water and concentrate. Water samples were collected from the surface seawater, the intakes (wells for site A, 9 m depth open ocean intake at site B), after the media filter, after the cartridge filter, and from the permeate and reject streams. The measured parameters included physical parameters, algae, bacteria, total organic carbon (TOC), fractions of dissolved NOM, particulate and colloidal TEP. The results of this study prove that the natural filtration and biological treatment of the seawater which occur in the aquifer matrix are very effective in improving the raw water quality to a significant degree. The results demonstrated that algae and biopolymers were 100% removed, the bacterial concentrations were significantly removed and roughly 50% or greater of TOC concentrations was eliminated by the aquifer matrix at site A. The aquifer feeding the vertical wells reduced TEP concentrations, but to differing degree. There is a slight decrease in the concentrations of

  5. Microbial extracellular polymeric substances in marine biogeochemical processes

    Digital Repository Service at National Institute of Oceanography (India)

    Bhaskar, P.V.; Bhosle, N.B.

    homopolysaccharide made of a-1-6 glucan monomers with 1?3 branched linkages () and bacteria alginate, a heteropolysaccharide having a combination of D-mannuronic acid and L-guluronic acid linked by b-1,6 linkage ( ). a b REVIEW ARTICLES CURRENT SCIENCE, VOL... extent of bacteria. On the other hand, some of the abiotic modes of TEP production from DOM include bubble adsorption, surface coagultion, turbulent shear and laminar she 11. Once released into the surrounding waters either actively (as EPS...

  6. EarthCache as a Tool to Promote Earth-Science in Public School Classrooms

    Science.gov (United States)

    Gochis, E. E.; Rose, W. I.; Klawiter, M.; Vye, E. C.; Engelmann, C. A.

    2011-12-01

    Geoscientists often find it difficult to bridge the gap in communication between university research and what is learned in the public schools. Today's schools operate in a high stakes environment that only allow instruction based on State and National Earth Science curriculum standards. These standards are often unknown by academics or are written in a style that obfuscates the transfer of emerging scientific research to students in the classroom. Earth Science teachers are in an ideal position to make this link because they have a background in science as well as a solid understanding of the required curriculum standards for their grade and the pedagogical expertise to pass on new information to their students. As part of the Michigan Teacher Excellence Program (MiTEP), teachers from Grand Rapids, Kalamazoo, and Jackson school districts participate in 2 week field courses with Michigan Tech University to learn from earth science experts about how the earth works. This course connects Earth Science Literacy Principles' Big Ideas and common student misconceptions with standards-based education. During the 2011 field course, we developed and began to implement a three-phase EarthCache model that will provide a geospatial interactive medium for teachers to translate the material they learn in the field to the students in their standards based classrooms. MiTEP participants use GPS and Google Earth to navigate to Michigan sites of geo-significance. At each location academic experts aide participants in making scientific observations about the locations' geologic features, and "reading the rocks" methodology to interpret the area's geologic history. The participants are then expected to develop their own EarthCache site to be used as pedagogical tool bridging the gap between standards-based classroom learning, contemporary research and unique outdoor field experiences. The final phase supports teachers in integrating inquiry based, higher-level learning student

  7. Methylselenium and Prostate Cancer Apoptosis

    Science.gov (United States)

    2007-02-01

    MMAC1/TEP1 involvement in primary prostate cancers. Oncogene, 16, 2879--2883. 22.Feilotter,H.E., Nagai,M.A., Boag,A.H., Eng,C. and Mulligan ,L.M. (1998...bearing phosphatidylinositol ether lipid analogues and carbonate surro- gates block PI3-K, Akt, and cancer cell growth. J. Med. Chem., 43, 3045--3051. 37...incubated at 37jC for 15 minutes. Fluorescence intensity was measured using a Becton Dickinson flow cytometer with excitation at 488 nm and emission at

  8. La incorporación de las TIC en la virtualidad de las distintas modalidades del aprendizaje en la UNdeC

    OpenAIRE

    Quiroga Salomón, Gabriel; Eines, Mónica Elsa

    2015-01-01

    El presente trabajo describe la implementación de un programa de acciones para la incorporación de TIC en los procesos de enseñanza-aprendizaje en la UNdeC. En la actualidad las instituciones introducen TIC en los procesos de enseñanza-aprendizaje. Es importante explorar que estas acciones se apoyen en marcos teóricos y prácticas educativas que permitan pasar de las TIC a las TAC y más aún a las TEP. Luego de una investigación, que permitió formular el marco teórico del presente proyect...

  9. Tutoría entre pares: primera experiencia de curso curricular opcional de la Udelar

    OpenAIRE

    Soane, Mariana; Hernández, Ofelia; Novelli, Dante; Fernández, Monica; Piccardo, Virginia; Collazo, Mercedes

    2017-01-01

    En el marco de las políticas definidas por la Universidad de la República (Udelar) de respaldo al aprendizaje, la Facultad de Odontología presenta su Curso de Tutoría Entre Pares (TEP) como primera experiencia curricular de integración estudiantil. Con un modelo de acceso abierto, los estudiantes de la Udelar ingresan sin ningún tipo de restricción a las carreras universitarias, pudiéndose inscribir en varias de ellas a la vez. Si bien no se cuenta con datos precisos sobre el grado de desvinc...

  10. CO2-emission trading and green markets for renewable electricity. WILMAR - deliverable 4.1

    International Nuclear Information System (INIS)

    Azuma-Dicke, N.; Weber, C.; Morthorst, P.E.; Ravn, H.F.; Schmidt, R.

    2004-06-01

    This report is Deliverable 4.1 of the EU project 'Wind Power Integration in Liberalised Electricity Markets' (WILMAR) and de-scribes the application of two policy instruments, Tradable Emissions Permits (TEPs) and Tradable Green Certificates (TGCs) for electricity produced from renewable energy sources in the European Union and the implications for implementation in the Wilmar model. The introduction of a common emission-trading system in the EU is expected to have an upward effect on the spot prices at the electric-ity market. The variations of the spot price imply that some types of power generation may change the situation from earning money to losing money despite the increasing spot price. Heavy restrictions on emissions penalise the fossil-fuelled technologies significantly, and the associated increase in the spot price need not compensate for this. Therefore, a market of TEPs is expected to have a significant influence on the electricity spot price. However, the expected price level of TEPs are met with great uncertainty and a study of a number of economical studies shows a price span between zero and 270 USD per ton of CO 2 depending on the participation or non-participation of countries in the scheme. The price-determination at the TGC market is expected to be closely related to the price at the power spot market as the RE-producers of electricity will have expectations to the total price paid for the energy produced, i.e., for the price of electricity at the spot market plus the price per kWh obtained at the green certificate mar-ket. In the Wilmar model, the TGC market can either be handled exogenously, i.e., the increase in renewable capacity and an average annual TGC price are determined outside the model, or a simple TGC module is developed, including the long-term supply functions for the most relevant renewable technologies and an overall TGC quota. Both solutions are rather simple, but to develop a more advanced model for the TGC market seems to be

  11. Establishing an EnvironMentors Project to Guide Minority Students into Science, Technology, and Environmental Careers

    Energy Technology Data Exchange (ETDEWEB)

    Montague, W. E.

    2003-01-24

    This report of the EnvironMentors Project (TEP) for the period February 1994 through December 1998, provides a summary of activities at our program sites and of our overall organizational accomplishments. Notably, the EnvironMentors Project matched 506 teens from under-resourced neighborhoods in Washington (DC), Trenton (NJ), and Baltimore (MD) with mentors, engaged more than 1,600 members of the public in informative discussions of environmental research, and presented interactive environmental education lessons to approximately 5,700 elementary and middle school children.

  12. A Well-Clear Volume Based on Time to Entry Point

    Science.gov (United States)

    Narkawicz, Anthony J.; Munoz, Cesar A.; Upchurch, Jason M.; Chamberlain, James P.; Consiglio, Maria C.

    2014-01-01

    A well-clear volume is a key component of NASA's Separation Assurance concept for the integration of UAS in the NAS. This paper proposes a mathematical definition of the well-clear volume that uses, in addition to distance thresholds, a time threshold based on time to entry point (TEP). The mathematical model that results from this definition is more conservative than other candidate definitions of the wellclear volume that are based on range over closure rate and time to closest point of approach.

  13. Herniorrafia inguinal laparoscópica totalmente extraperitoneal: vinte e sete complicações graves após 4565 operações consecutivas

    Directory of Open Access Journals (Sweden)

    Alberto Meyer

    Full Text Available OBJETIVO: identificar e avaliar as complicações do tratamento da hérnia inguinal com a colocação de tela totalmente extraperitoneal. MÉTODOS: Foram incluídos, em uma série consecutiva de 4565 reparos de hérnia laparoscópica, pacientes que haviam sido submetidos ao procedimento TEP entre janeiro de 2001 e janeiro de 2011. Os critérios de inclusão foram: diagnóstico com hérnia inguinal sintomática, incluindo recorrência após correção de hérnia inguinal e cirurgia prévia em abdômen inferior e pelve. Todos os pacientes > 18 anos de idade. Pacientes com hérnia encarcerada na urgência foram excluídos do estudo. RESULTADOS: Um total de 4565 hérnias foram incluídas no estudo. Ocorreram 27 complicações graves (0,6%: 12 hemorragias (0,25%, duas lesões da bexiga (0,04%, cinco oclusões (0,11%, quatro perfurações intestinais (0,09%, uma lesão da veia ilíaca (0,02%, uma lesão do nervo femoral (0,02%, duas lesões dos vasos deferentes (0,04% e dois óbitos (0,02% (embolia pulmonar, peritonite. CONCLUSÃO: A taxa de complicações com o procedimento TEP é baixa. Correção de hérnia laparoscópica é uma técnica reprodutível e confiável. Em nossa experiência, existem contraindicações para o procedimento de TEP. A técnica TEP deve ser minuciosa para evitar complicações intraoperatórias (diatermia bipolar. As complicações podem ocorrer mesmo após o cirurgião ter adquirido experiência substancial.

  14. Cleaning protocol for a FO membrane fouled in wastewater reuse

    KAUST Repository

    Valladares Linares, Rodrigo

    2013-05-30

    Forward osmosis (FO) is an emerging technology which can be applied in water reuse applications. Osmosis is a natural process that involves less energy consumption than reverse osmosis (RO), and therefore can be applied as a dilution process before low-pressure RO; it is expected to compete favourably against current advanced water reuse technologies that use microfiltration/ultrafiltration and RO. The focus of this research was to assess the efficiency of different cleaning procedures to remove fouling from the surface of a FO membrane during the operation of a submerged system working in FO-mode (active layer (AL) facing feed solution) intended for secondary wastewater effluent (SWWE) recovery, using seawater as draw solution (DS), which will be diluted and can further be fed to a low-pressure RO unit to produce fresh water. Natural organic matter (NOM) fouling was expected to affect the AL, while for the support layer (SL), transparent exopolymer particles (TEP) were used as indicators of fouling due to their stickiness and propensity to enhance the attachment of other foulants in seawater on the membrane surface. The composition of the NOM fouling layer was determined after proper characterisation with a liquid chromatograph coupled with organic carbon detection (LC-OCD), showing biopolymers and protein-like substances as the main constituents. NOM fouling showed high hydraulic reversibility after a 25% flux decline was observed, up to 89.5% when in situ air scouring for 15 min was used as a cleaning technique. Chemical cleaning with a mixture of Alconox, an industrial detergent containing phosphates, and sodium EDTA showed to increase the reversibility (93.6%). Osmotic backwash using a 4% NaCl solution and DI water proved to be ineffective to recover flux due to the salt diffusion phenomena occurring at the AL. Part of the flux that could not be recovered is attributable to TEP fouling on the SL, which forms clusters clearly identifiable with an optical

  15. 173. Carcinoma renal con trombosis de vena cava y extensión a aurícula derecha: Una técnica novedosa sin hipotermia profunda ni parada cardiocirculatoria

    Directory of Open Access Journals (Sweden)

    A.M. Bel Mínguez

    2012-04-01

    Resultados: No hubo muertes quirúrgicas ni intrahospitalarias. El tiempo medio de circulación extracorpórea (CEC fue de 189 min. La estancia media en la unidad de cuidados intensivos (UCI fue de 7 días (rango 4–33 y la estancia postoperatoria media de 19 días (rango 15–60. Hubo un caso de tromboembolismo pulmonar (TEP intraoperatorio. Un paciente desarrolló una encefalopatía hipoxicoanóxica.

  16. Serum cortisol and blood glucose in bitches treated with tramadol and submitted to ovariohysterectomy

    OpenAIRE

    Caldeira, Fátima Maria Caetano; Oliveira, Humberto Pereira; Melo, Eliane Gonçalves; Martins, Claudia; Vieira, Marilisa Souza; Silva, Cristiano Nicomedes da

    2006-01-01

    O tramadol é um analgésico opióide usado em medicina veterinária, embora existam poucos estudos sobre este fármaco. O objetivo deste trabalho foi avaliar o efeito analgésico promovido pela administração do tramadol, mensurando o cortisol sérico e a glicemia de cadelas. Para isso, foram utilizadas 15 fêmeas, submetidas a ovário-histerectomia sob anestesia geral com isofluorano. Os animais foram divididos em três grupos. Grupo 1 (Tep) receberam tramadol pela via epidural (1,0mg kg-1 diluído em ...

  17. Cortisol sérico e glicemia em cadelas tratadas com tramadol e submetidas à ovário-histerectomia

    OpenAIRE

    Caldeira Fátima Maria Caetano; Oliveira Humberto Pereira; Melo Eliane Gonçalves; Martins Claudia; Vieira Marilisa Souza; Silva Cristiano Nicomedes da

    2006-01-01

    O tramadol é um analgésico opióide usado em medicina veterinária, embora existam poucos estudos sobre este fármaco. O objetivo deste trabalho foi avaliar o efeito analgésico promovido pela administração do tramadol, mensurando o cortisol sérico e a glicemia de cadelas. Para isso, foram utilizadas 15 fêmeas, submetidas a ovário-histerectomia sob anestesia geral com isofluorano. Os animais foram divididos em três grupos. Grupo 1 (Tep) receberam tramadol pela via epidural (1,0mg kg-1 diluído em ...

  18. Composition of CBRN Decontamination Effluent and Development of Surrogate Mixtures for Testing Effluent Treatment Technologies

    Science.gov (United States)

    2016-07-01

    decontamination for the U.S. Air Force (Heater et al. 2011), which ranges from 1-10 g/m2. The Edgewood Chemical Biological Center (ECBC) used this loading...organophosphate pesticides and warfare agents. TEP has a molecular weight of 182 g/mol and a density of 1.072 g/mL. It is miscible in water, and Gas...Commercially available *Not as toxic as other organophosphates, still used as a pesticide and control of mosquitoes *Somewhat expensive $36.70 for 100 mg

  19. Rural residential energy consumption not electrified in the Municipality of Petrolina-PE, Brazil; Consumo energetico residencial rural nao eletrificado do municipio de Petrolina-PE

    Energy Technology Data Exchange (ETDEWEB)

    Borges Neto, Manuel Rangel; Lopes, Luiz Carlos Nascimento [Centro Federal de Educacao Tecnologica de Petrolina (CEFET/PET), CE (Brazil); Carvalho, Paulo Cesar Marques de [Universidade Federal do Ceara (PPGEE/UFC), Fortaleza (Brazil). Programa de Pos Graduacao em Engenharia Eletrica

    2006-07-01

    This paper brings a study about the energetic profile consumption of the residential rural off-grid population in Petrolina- PE municipality. A community was chose as a sample and trough some interviews it was possible to get enough data to estimate the energetic consumption of this segment in the county. In conclusion it has a specific annual consumption of 0,125 tep/hab, 5.9% higher than the Brazilian average and that the firewood is the source to 91,87% of the energy final use. (author)

  20. Project W-314 specific test and evaluation plan for 241-AN-A valve pit

    International Nuclear Information System (INIS)

    Hays, W.H.

    1997-01-01

    The purpose of this Specific Test and Evaluation Plan (STEP) is to provide a detailed written plan for the systematic testing of modifications made to the 241-AN-A Valve Pit by the W-314 Project. The STEP develops the outline for test procedures that verify the system's performance to the established Project design criteria. The STEP is a ''lower tier'' document based on the W-314 Test and Evaluation Plan (TEP) This STEP encompasses all testing activities required to demonstrate compliance to the project design criteria as it relates to the modifications of the AN-A valve pit. The Project Design Specifications (PDS) identify the specific testing activities required for the Project. Testing includes Validations and Verifications (e.g., Commercial Grade Item Dedication activities), Factory Acceptance Tests (FATs), installation tests and inspections, Construction Acceptance Tests (CATs), Acceptance Test Procedures (ATPs), Pre-Operational Test Procedures (POTPs), and Operational Test Procedures (OTPs). It should be noted that POTPs are not required for testing of the modifications to the 241-AN-A Valve Pit. The STEP will be utilized in conjunction with the TEP for verification and validation

  1. Investigating consummatory and anticipatory pleasure across motivation deficits in schizophrenia and healthy controls.

    Science.gov (United States)

    Da Silva, Susana; Saperia, Sarah; Siddiqui, Ishraq; Fervaha, Gagan; Agid, Ofer; Daskalakis, Z Jeff; Ravindran, Arun; Voineskos, Aristotle N; Zakzanis, Konstantine K; Remington, Gary; Foussias, George

    2017-08-01

    Anhedonia has traditionally been considered a characteristic feature of schizophrenia, but the true nature of this deficit remains elusive. This study sought to investigate consummatory and anticipatory pleasure as it relates to motivation deficits. Eighty-four outpatients with schizophrenia and 81 healthy controls were administered the Temporal Experience of Pleasure Scale (TEPS), as well as a battery of clinical and cognitive assessments. Multivariate analyses of variance were used to examine the experience of pleasure as a function of diagnosis, and across levels of motivation deficits (i.e. low vs. moderate. vs. high) in schizophrenia. Hierarchical regression analyses were also conducted to evaluate the predictive value of amotivation in relation to the TEPS. There were no significant differences between schizophrenia and healthy control groups for either consummatory or anticipatory pleasure. Within the schizophrenia patients, only those with high levels of amotivation were significantly impaired in consummatory and anticipatory pleasure compared to low and moderate groups, and compared to healthy controls. Further, our results revealed that amotivation significantly predicts both consummatory and anticipatory pleasure, with no independent contribution of group. Utilizing study samples with a wide range of motivation deficits and incorporating objective paradigms may provide a more comprehensive understanding of hedonic deficits. Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.

  2. A multi-stage stochastic transmission expansion planning method

    International Nuclear Information System (INIS)

    Akbari, Tohid; Rahimikian, Ashkan; Kazemi, Ahad

    2011-01-01

    Highlights: → We model a multi-stage stochastic transmission expansion planning problem. → We include available transfer capability (ATC) in our model. → Involving this criterion will increase the ATC between source and sink points. → Power system reliability will be increased and more money can be saved. - Abstract: This paper presents a multi-stage stochastic model for short-term transmission expansion planning considering the available transfer capability (ATC). The ATC can have a huge impact on the power market outcomes and the power system reliability. The transmission expansion planning (TEP) studies deal with many uncertainties, such as system load uncertainties that are considered in this paper. The Monte Carlo simulation method has been applied for generating different scenarios. A scenario reduction technique is used for reducing the number of scenarios. The objective is to minimize the sum of investment costs (IC) and the expected operation costs (OC). The solution technique is based on the benders decomposition algorithm. The N-1 contingency analysis is also done for the TEP problem. The proposed model is applied to the IEEE 24 bus reliability test system and the results are efficient and promising.

  3. The major yolk protein vitellogenin interferes with the anti-plasmodium response in the malaria mosquito Anopheles gambiae.

    Directory of Open Access Journals (Sweden)

    Martin K Rono

    Full Text Available When taking a blood meal on a person infected with malaria, female Anopheles gambiae mosquitoes, the major vector of human malaria, acquire nutrients that will activate egg development (oogenesis in their ovaries. Simultaneously, they infect themselves with the malaria parasite. On traversing the mosquito midgut epithelium, invading Plasmodium ookinetes are met with a potent innate immune response predominantly controlled by mosquito blood cells. Whether the concomitant processes of mosquito reproduction and immunity affect each other remains controversial. Here, we show that proteins that deliver nutrients to maturing mosquito oocytes interfere with the antiparasitic response. Lipophorin (Lp and vitellogenin (Vg, two nutrient transport proteins, reduce the parasite-killing efficiency of the antiparasitic factor TEP1. In the absence of either nutrient transport protein, TEP1 binding to the ookinete surface becomes more efficient. We also show that Lp is required for the normal expression of Vg, and for later Plasmodium development at the oocyst stage. Furthermore, our results uncover an inhibitory role of the Cactus/REL1/REL2 signaling cassette in the expression of Vg, but not of Lp. We reveal molecular links that connect reproduction and immunity at several levels and provide a molecular basis for a long-suspected trade-off between these two processes.

  4. Complement-related proteins control the flavivirus infection of Aedes aegypti by inducing antimicrobial peptides.

    Directory of Open Access Journals (Sweden)

    Xiaoping Xiao

    2014-04-01

    Full Text Available The complement system functions during the early phase of infection and directly mediates pathogen elimination. The recent identification of complement-like factors in arthropods indicates that this system shares common ancestry in vertebrates and invertebrates as an immune defense mechanism. Thioester (TE-containing proteins (TEPs, which show high similarity to mammalian complement C3, are thought to play a key role in innate immunity in arthropods. Herein, we report that a viral recognition cascade composed of two complement-related proteins limits the flaviviral infection of Aedes aegypti. An A. aegypti macroglobulin complement-related factor (AaMCR, belonging to the insect TEP family, is a crucial effector in opposing the flaviviral infection of A. aegypti. However, AaMCR does not directly interact with DENV, and its antiviral effect requires an A. aegypti homologue of scavenger receptor-C (AaSR-C, which interacts with DENV and AaMCR simultaneously in vitro and in vivo. Furthermore, recognition of DENV by the AaSR-C/AaMCR axis regulates the expression of antimicrobial peptides (AMPs, which exerts potent anti-DENV activity. Our results both demonstrate the existence of a viral recognition pathway that controls the flaviviral infection by inducing AMPs and offer insights into a previously unappreciated antiviral function of the complement-like system in arthropods.

  5. Graphene oxide/MnO2 nanocomposite as destructive adsorbent of nerve-agent simulants in aqueous media

    International Nuclear Information System (INIS)

    Šťastný, Martin; Tolasz, Jakub; Štengl, Václav; Henych, Jiří; Žižka, David

    2017-01-01

    Highlights: • Nanocomposite graphene oxide-birnessite-type MnO 2 was synthesized by thermal hydrolysis. • New destructive sorbent for safe degradation of nerve-agent simulants. • 95% degradation activity for DMMP and TEP. - Abstract: Graphene oxide/MnO 2 nanocomposite was prepared by thermal hydrolysis of potassium permanganate (KMnO 4 ) and 2-chloroacetamide aqueous solutions with graphene oxide (GO) suspension. The synthesized samples were characterized by specific surface area (BET) and porosity determination (BJH), X-ray Diffraction (XRD) and high-resolution electron microscopes (HRSEM, HRTEM). These nanocomposites were used in an experimental evaluation of their adsorption activity with nerve agent simulants dimethyl methyl phosphonate (DMMP) and triethyl phosphate (TEP) in aqueous media. The nanocomposites exhibited enhanced adsorptive degradation ability compared to pure manganese oxide (MnO 2 ) and GO. The GO amount in the nanocomposites affected their degradation activity substantially. The best adsorption efficiency was observed for samples with moderate GO amount. Three methods were used to observe the mechanism of the nerve-agent simulants deactivation: Gas chromatography with mass spectrometry (GC–MS), High-Performance Liquid Chromatography (HPLC) and in situ Infrared spectroscopy (FTIR). It was shown that the hydrolysis on the surface of prepared nanocomposites yields volatile primary alcohols (methanol and ethanol) as the main hydrolysis products.

  6. [European Marketing Authorisation: a long process. Experiences of small biotech companies with the ATMP regulation].

    Science.gov (United States)

    Buljovčić, Z

    2011-07-01

    On 30 December 2008, the Regulation (EC) 1394/2007 on advanced therapy medicinal products (ATMPs) entered into force. Herewith the first EU-wide regulatory framework for ATMPs was established. It requires a central marketing authorisation application to the EMA (European Medicinal Agency). This new framework especially changes the code of regulatory practice for tissue engineered products (TEPs), as no registration procedure had been previously required for autologous TEPs. This also meant that no clinical proof of efficacy achieved by a pivotal clinical trial was necessary. Difficulties and their background as well as the vast requirements for product development that have to be addressed by small companies within a very short time frame are presented. Hereby, it is obvious that regulatory experience which is required to identify and implement the resulting implications was not in place yet and still had to be established. The lack of regulatory experience also resulted in difficulties with scientific advice preparation, expectations toward regulatory agencies, consultants, and transformation of regulatory requirements. Addressing the regulatory requirements within the transition period is even more difficult for entrepreneurs with products which are assigned for indications resulting in complex challenges to the trial design. Due to the enormous time pressure to generate data and due to the implied financial pressure, different adaptation strategies are evolving. In Germany the "hospital exemption" according to §4b AMG (German Medicinal Products Law) is of major importance. A reorientation toward acellular products and a slow down in development of new ATMP products is expected.

  7. Tromboembolismo pulmonar crônico: papel da angiotomografia

    Directory of Open Access Journals (Sweden)

    Rogério Ferrari Peron

    2007-10-01

    Full Text Available Hipertensão pulmonar por tromboembolismo pulmonar (TEP crônico é freqüentemente subdiagnosticada e tem prognóstico sombrio se não tratada adequadamente. Quando a presença de trombo arterial é confirmada, tromboendarterectomia é o tratamento de escolha, com resultados favoráveis. Relatamos caso de paciente masculino, 52 anos, com dispnéia aos esforços havia quatro meses, sem quadro clínico agudo de TEP ou de TVP. O ecocardiograma mostrava hipertensão pulmonar moderada e angiotomografia de tórax revelou êmbolos em artérias pulmonares direita e esquerda, artérias lobares e segmentares, bilateralmente. Cortes tomográficos em membros inferiores revelaram trombo em veia poplítea direita. Outros casos de trombose de membros inferiores na família sugerem a possibilidade de trombofilia. Paciente foi tratado com warfarina com sucesso e dois meses após, o ecocardiograma e a angiotomografia estavam normais e não foi necessário indicar tromboendarterectomia.

  8. Flexible Multi-Objective Transmission Expansion Planning with Adjustable Risk Aversion

    Directory of Open Access Journals (Sweden)

    Jing Qiu

    2017-07-01

    Full Text Available This paper presents a multi-objective transmission expansion planning (TEP framework. Rather than using the conventional deterministic reliability criterion, a risk component based on the probabilistic reliability criterion is incorporated into the TEP objectives. This risk component can capture the stochastic nature of power systems, such as load and wind power output variations, component availability, and incentive-based demand response (IBDR costs. Specifically, the formulation of risk value after risk aversion is explicitly given, and it aims to provide network planners with the flexibility to conduct risk analysis. Thus, a final expansion plan can be selected according to individual risk preferences. Moreover, the economic value of IBDR is modeled and integrated into the cost objective. In addition, a relatively new multi-objective evolutionary algorithm called the MOEA/D is introduced and employed to find Pareto optimal solutions, and tradeoffs between overall cost and risk are provided. The proposed approach is numerically verified on the Garver’s six-bus, IEEE 24-bus RTS and Polish 2383-bus systems. Case study results demonstrate that the proposed approach can effectively reduce cost and hedge risk in relation to increasing wind power integration.

  9. From solid solution to cluster formation of Fe and Cr in α-Zr

    International Nuclear Information System (INIS)

    Burr, P.A.; Wenman, M.R.; Gault, B.; Moody, M.P.; Ivermark, M.; Rushton, M.J.D.; Preuss, M.; Edwards, L.; Grimes, R.W.

    2015-01-01

    To understand the mechanisms by which the re-solution of Fe and Cr additions increase the corrosion rate of irradiated Zr alloys, the solubility and clustering of Fe and Cr in model binary Zr alloys was investigated using a combination of experimental and modelling techniques — atom probe tomography (APT), x-ray diffraction (XRD), thermoelectric power (TEP) and density functional theory (DFT). Cr occupies both interstitial and substitutional sites in the α-Zr lattice; Fe favours interstitial sites, and a low-symmetry site that was not previously modelled is found to be the most favourable for Fe. Lattice expansion as a function of Fe and Cr content in the α-Zr matrix deviates from Vegard's law and is strongly anisotropic for Fe additions, expanding the c-axis while contracting the a-axis. Matrix content of solutes cannot be reliably estimated from lattice parameter measurements, instead a combination of TEP and APT was employed. Defect clusters form at higher solution concentrations, which induce a smaller lattice strain compared to the dilute defects. In the presence of a Zr vacancy, all two-atom clusters are more soluble than individual point defects and as many as four Fe or three Cr atoms could be accommodated in a single Zr vacancy. The Zr vacancy is critical for the increased apparent solubility of defect clusters; the implications for irradiation induced microstructure changes in Zr alloys are discussed.

  10. Project W-314 specific test and evaluation plan for SN-633 transfer line (241-AX-B to 241-AY-02A)

    International Nuclear Information System (INIS)

    Hays, W.H.

    1998-01-01

    The purpose of this Specific Test and Evaluation Plan (STEP) is to provide a detailed written plan for the systematic testing of modifications made by the addition of the SN-633 transfer line by the W-314 Project. The STEP develops the outline for test procedures that verify the system's performance to the established Project design criteria. The STEP is a lower tier document based on the W-314 Test and Evaluation Plan (TEP). This STEP encompasses all testing activities required to demonstrate compliance to the project design criteria as it relates to the addition of transfer line SN-633. The Project Design Specifications (PDS) identify the specific testing activities required for the Project. Testing includes Validations and Verifications (e.g., Commercial Grade Item Dedication activities), Factory Acceptance Tests (FATs), installation tests and inspections, Construction Acceptance Tests (CATs), Acceptance Test Procedures (ATPs), Pre-Operational Test Procedures (POTPs), and Operational Test Procedures (OTPs). It should be noted that POTPs are not required for testing of the transfer line addition. The STEP will be utilized in conjunction with the TEP for verification and validation

  11. The TROVE module: A common element in Telomerase, Ro and Vault ribonucleoproteins

    Directory of Open Access Journals (Sweden)

    Bateman Alex

    2003-10-01

    Full Text Available Abstract Background Ribonucleoproteins carry out a variety of important tasks in the cell. In this study we show that a number of these contain a novel module, that we speculate mediates RNA-binding. Results The TROVE module – Telomerase, Ro and Vault module – is found in TEP1 and Ro60 the protein components of three ribonucleoprotein particles. This novel module, consisting of one or more domains, may be involved in binding the RNA components of the three RNPs, which are telomerase RNA, Y RNA and vault RNA. A second conserved region in these proteins is shown to be a member of the vWA domain family. The vWA domain in TEP1 is closely related to the previously recognised vWA domain in VPARP a second component of the vault particle. This vWA domain may mediate interactions between these vault components or bind as yet unidentified components of the RNPs. Conclusions This work suggests that a number of ribonucleoprotein components use a common RNA-binding module. The TROVE module is also found in bacterial ribonucleoproteins suggesting an ancient origin for these ribonucleoproteins.

  12. The TROVE module: a common element in Telomerase, Ro and Vault ribonucleoproteins.

    Science.gov (United States)

    Bateman, Alex; Kickhoefer, Valerie

    2003-10-16

    Ribonucleoproteins carry out a variety of important tasks in the cell. In this study we show that a number of these contain a novel module, that we speculate mediates RNA-binding. The TROVE module--Telomerase, Ro and Vault module--is found in TEP1 and Ro60 the protein components of three ribonucleoprotein particles. This novel module, consisting of one or more domains, may be involved in binding the RNA components of the three RNPs, which are telomerase RNA, Y RNA and vault RNA. A second conserved region in these proteins is shown to be a member of the vWA domain family. The vWA domain in TEP1 is closely related to the previously recognised vWA domain in VPARP a second component of the vault particle. This vWA domain may mediate interactions between these vault components or bind as yet unidentified components of the RNPs. This work suggests that a number of ribonucleoprotein components use a common RNA-binding module. The TROVE module is also found in bacterial ribonucleoproteins suggesting an ancient origin for these ribonucleoproteins.

  13. Performance characteristics of the 12 GHz, 200 watt Transmitter Experiment Package for CTS. [Communication Technology Satellite

    Science.gov (United States)

    Miller, E. F.; Fiala, J. L.; Hansen, I. G.

    1975-01-01

    Measured performance characteristics from ground test of the Transmitter Experiment Package (TEP) for the Communications Technology Satellite are presented. The experiment package consists of a 200 W Output Stage Tube (OST) powered by a Power Processing System (PPS). Descriptions of both the PPS and OST are given. The PPS provides the necessary voltages with a measured dc/dc conversion efficiency of 89 per cent. The OST, a traveling wave tube with multiple collectors, has a saturated rf output power of 224 W and operates at an overall efficiency exceeding 40 per cent over an 85 MHz bandwidth at 12 GHz. OST performance given includes frequency response, saturation characteristics, group delay, AM to PM conversion, intermodulation distortion, and two channel gain suppression. Single and dual channel FM video performance is presented. It was determined that for 12 MHz peak to peak frequency deviation on each channel, dual channel FM television signals can be transmitted through the TEP at 60 W, each channel, with 40 MHz channel spacing (center to center).

  14. Potentially life-threatening coagulopathy associated with simultaneous reduction in coagulation and fibrinolytic function in pediatric acute leukemia after hematopoietic stem-cell transplantation.

    Science.gov (United States)

    Ishihara, Takashi; Nogami, Keiji; Matsumoto, Tomoko; Nomura, Akitaka; Takeshita, Yasufumi; Ochi, Satoshi; Shima, Midori

    2017-07-01

    The pathogenesis of sinusoidal obstruction syndrome (SOS) and thrombotic microangiopathy (TMA) after hematopoietic stem cell transplantation (HSCT) is poorly understood, and limited information is available on global hemostatic function in HSCT. We assessed changes in coagulation and fibrinolysis using a simultaneous thrombin and plasmin generation assay (T/P-GA) during HSCT. Measurements of endogenous thrombin potential (T-EP) and plasmin peak height (P-Peak) using T/P-GA in six pediatric acute leukemia patients treated with HSCT were compared to normal plasma. In the SOS case, the ratios of T-EP and P-Peak to normal were simultaneously decreased at four weeks post-HSCT (Pre; ~1.1/1.1-1.4, Week+4; 0.14/0.0084, respectively). Similarly, in the TMA patient, both ratios were decreased at 3 weeks and recovered after 8 weeks (Pre; 1.2/~0.95, Week+3; 0.59/0.22, Week+8; 1.2/0.64-0.85). In the other patients, when SOS/TMA was not evident, the T/P-GA data remained within normal limits. These findings suggest that the simultaneous reduction of coagulation and fibrinolytic function in patients developing SOS/TMA can lead to a life-threatening coagulopathy. Further research is warranted to clarify global hemostatic function after HSCT to establish optimal supportive therapy for these critical clinical disorders of hemostasis.

  15. T-Flap advances: instrumental and operative implementation

    Science.gov (United States)

    Marcelli, M.; Piermattei, V.; Mainardi, U.

    2012-04-01

    Within the European MFS-TEP project a new expendable vertical profiler for fluorescence of chlorophyll a, pressure and temperature measuring was developed: the T-Flap (Temperature Fluorescence LAunchable Probe). The main features of this instrument concern the fluorescence measure in expendable mode, the low cost components, the electronics miniaturization, the modularity and flexibility of the system for a multi purpose application. This technology has filled a gap in the measurements of chlorophyll a fluorescence, infact as compared with various instruments for measuring physical variables, there is a lack for the measurement of ecological and biological once. The measurement of chlorophyll a fluorescence is of fundamental importance as the basis for the estimation of phytoplankton biomass and thus the study of primary production in the seas. As a result of the technological development achieved in MFS-TEP project has been awarded an European patent (EP1962089A1). Afterward during the ADRICOSM-STAR project some improvements of the probe were carried out and experimental tests were performed during an oceanographic cruise. The tests have led to an upgrade of instrumentation and sensors and to the realization of new prototypes. This new technology could be used in different operative applications: profiler along the water column (not expendable) and stand alone (in continuous surface acquisitions along tracks, in continuous acquisition on a buoy). This work shows the technical characteristics of the instrument and the potential applications.

  16. Air pollutant characterization in Tula industrial corridor, Central Mexico, during the MILAGRO study.

    Science.gov (United States)

    Sosa, G; Vega, E; González-Avalos, E; Mora, V; López-Veneroni, D

    2013-01-01

    Pollutant emissions and their contribution to local and regional air quality at the industrial area of Tula were studied during a four-week period as part of the MILAGRO initiative. A recurrent shallow stable layer was observed in the morning favoring air pollutants accumulation in the lower 100 m atmospheric layer. In the afternoon the mixing layer height reached 3000 m, along with a featuring low level jet which was responsible of transporting air pollutants at regional scales. Average PM10 at Jasso (JAS) and Tepeji (TEP) was 75.1 and 36.8 μ g/m(3), respectively while average PM2.5 was 31.0 and 25.7 μ g/m(3). JAS was highly impacted by local limestone dust, while TEP was a receptor of major sources of combustion emissions with 70% of the PM10 constituted by PM2.5. Average hourly aerosol light absorption was 22 Mm(-1), while aerosol scattering (76 Mm(-1)) was higher compared to a rural site but much lower than at Mexico City. δ(13)C values in the epiphyte Tillandsia recurvata show that the emission plume directly affects the SW sector of Mezquital Valley and is then constrained by a mountain range preventing its dispersion. Air pollutants may exacerbate acute and chronic adverse health effects in this region.

  17. Functional analysis of the molecular interactions of TATA box-containing genes and essential genes.

    Science.gov (United States)

    Bae, Sang-Hun; Han, Hyun Wook; Moon, Jisook

    2015-01-01

    Genes can be divided into TATA-containing genes and TATA-less genes according to the presence of TATA box elements at promoter regions. TATA-containing genes tend to be stress-responsive, whereas many TATA-less genes are known to be related to cell growth or "housekeeping" functions. In a previous study, we demonstrated that there are striking differences among four gene sets defined by the presence of TATA box (TATA-containing) and essentiality (TATA-less) with respect to number of associated transcription factors, amino acid usage, and functional annotation. Extending this research in yeast, we identified KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways that are statistically enriched in TATA-containing or TATA-less genes and evaluated the possibility that the enriched pathways are related to stress or growth as reflected by the individual functions of the genes involved. According to their enrichment for either of these two gene sets, we sorted KEGG pathways into TATA-containing-gene-enriched pathways (TEPs) and essential-gene-enriched pathways (EEPs). As expected, genes in TEPs and EEPs exhibited opposite results in terms of functional category, transcriptional regulation, codon adaptation index, and network properties, suggesting the possibility that the bipolar patterns in these pathways also contribute to the regulation of the stress response and to cell survival. Our findings provide the novel insight that significant enrichment of TATA-binding or TATA-less genes defines pathways as stress-responsive or growth-related.

  18. Air Pollutant Characterization in Tula Industrial Corridor, Central Mexico, during the MILAGRO Study

    Directory of Open Access Journals (Sweden)

    G. Sosa

    2013-01-01

    Full Text Available Pollutant emissions and their contribution to local and regional air quality at the industrial area of Tula were studied during a four-week period as part of the MILAGRO initiative. A recurrent shallow stable layer was observed in the morning favoring air pollutants accumulation in the lower 100 m atmospheric layer. In the afternoon the mixing layer height reached 3000 m, along with a featuring low level jet which was responsible of transporting air pollutants at regional scales. Average PM10 at Jasso (JAS and Tepeji (TEP was 75.1 and 36.8 μg/m3, respectively while average PM2.5 was 31.0 and 25.7 μg/m3. JAS was highly impacted by local limestone dust, while TEP was a receptor of major sources of combustion emissions with 70% of the PM10 constituted by PM2.5. Average hourly aerosol light absorption was 22 Mm−1, while aerosol scattering (76 Mm−1 was higher compared to a rural site but much lower than at Mexico City. δ13C values in the epiphyte Tillandsia recurvata show that the emission plume directly affects the SW sector of Mezquital Valley and is then constrained by a mountain range preventing its dispersion. Air pollutants may exacerbate acute and chronic adverse health effects in this region.

  19. Graphene oxide/MnO{sub 2} nanocomposite as destructive adsorbent of nerve-agent simulants in aqueous media

    Energy Technology Data Exchange (ETDEWEB)

    Šťastný, Martin, E-mail: stastny@iic.cas.cz [Materials Chemistry Department, Institute of Inorganic Chemistry AS CR v.v.i., 25068 Husinec-Řež (Czech Republic); Faculty of the Environment, J.E. Purkyně University in Ústí nad Labem, Králova Výšina 7, 400 96 Ústí nad Labem (Czech Republic); Tolasz, Jakub; Štengl, Václav; Henych, Jiří [Materials Chemistry Department, Institute of Inorganic Chemistry AS CR v.v.i., 25068 Husinec-Řež (Czech Republic); Žižka, David [Faculty of the Environment, J.E. Purkyně University in Ústí nad Labem, Králova Výšina 7, 400 96 Ústí nad Labem (Czech Republic)

    2017-08-01

    Highlights: • Nanocomposite graphene oxide-birnessite-type MnO{sub 2} was synthesized by thermal hydrolysis. • New destructive sorbent for safe degradation of nerve-agent simulants. • 95% degradation activity for DMMP and TEP. - Abstract: Graphene oxide/MnO{sub 2} nanocomposite was prepared by thermal hydrolysis of potassium permanganate (KMnO{sub 4}) and 2-chloroacetamide aqueous solutions with graphene oxide (GO) suspension. The synthesized samples were characterized by specific surface area (BET) and porosity determination (BJH), X-ray Diffraction (XRD) and high-resolution electron microscopes (HRSEM, HRTEM). These nanocomposites were used in an experimental evaluation of their adsorption activity with nerve agent simulants dimethyl methyl phosphonate (DMMP) and triethyl phosphate (TEP) in aqueous media. The nanocomposites exhibited enhanced adsorptive degradation ability compared to pure manganese oxide (MnO{sub 2}) and GO. The GO amount in the nanocomposites affected their degradation activity substantially. The best adsorption efficiency was observed for samples with moderate GO amount. Three methods were used to observe the mechanism of the nerve-agent simulants deactivation: Gas chromatography with mass spectrometry (GC–MS), High-Performance Liquid Chromatography (HPLC) and in situ Infrared spectroscopy (FTIR). It was shown that the hydrolysis on the surface of prepared nanocomposites yields volatile primary alcohols (methanol and ethanol) as the main hydrolysis products.

  20. Rhodium, iridium and nickel complexes with a 1,3,5-triphenylbenzene tris-MIC ligand. Study of the electronic properties and catalytic activities

    Directory of Open Access Journals (Sweden)

    Carmen Mejuto

    2015-12-01

    Full Text Available The coordination versatility of a 1,3,5-triphenylbenzene-tris-mesoionic carbene ligand is illustrated by the preparation of complexes with three different metals: rhodium, iridium and nickel. The rhodium and iridium complexes contained the [MCl(COD] fragments, while the nickel compound contained [NiCpCl]. The preparation of the tris-MIC (MIC = mesoionic carbene complex with three [IrCl(CO2] fragments, allowed the estimation of the Tolman electronic parameter (TEP for the ligand, which was compared with the TEP value for a related 1,3,5-triphenylbenzene-tris-NHC ligand. The electronic properties of the tris-MIC ligand were studied by cyclic voltammetry measurements. In all cases, the tris-MIC ligand showed a stronger electron-donating character than the corresponding NHC-based ligands. The catalytic activity of the tri-rhodium complex was tested in the addition reaction of arylboronic acids to α,β-unsaturated ketones.

  1. Neural mobilization and static stretching in an experimental sciatica model: an experimental study Mobilização neural e alongamento estático em um modelo experimental de ciatalgia: estudo experimental

    Directory of Open Access Journals (Sweden)

    Gladson R. F. Bertolini

    2009-12-01

    Full Text Available OBJECTIVE: To verify the effectiveness of neural mobilization and static stretching in reducing pain in rats submitted to experimental sciatica. METHODS: The rats (n=23 were divided into three groups: sham (SG/n=8, without intervention; stretching (STCG/n=8, treated with static stretching; and neural mobilization (NMG/n=7, treated with neural mobilization. The animals underwent an experimental model of sciatica by compression of the right ischiatic nerve with catgut suture thread. There were five consecutive sessions of treatment that began on the third day after lesion. The pain caused by the sciatica was evaluated by a functional incapacitation test that measured paw elevation time (PET, and values over 10s were indicative of pain. PET was measured at the following moments: before the lesion (M1, immediately before (M2 and after the first session (M3, immediately after the last session (M4 and 24h after the last session (M5. ANOVA was applied with repeated measures and unrepeated measures for intra- and inter-group comparison, respectively. RESULTS: In the SG, post-lesion PETs were greater than M1 (pOBJETIVO: Verificar a eficácia da mobilização neural e do alongamento estático na redução da dor em ratos submetidos à ciática experimental. MÉTODOS: Os ratos (n=23 foram divididos em três grupos: simulacro (GS/n=8, sem intervenção; alongamento (GAL/n=8, tratados com alongamento estático; e mobilização neural (GMN/n=7, tratados com mobilização neural. Submeteram-se os animais a um modelo experimental de ciática, comprimindo o nervo isquiático direito com fio de catgut. Realizaram-se cinco sessões consecutivas de tratamento que se iniciaram no terceiro dia pós-lesão. Avaliou-se a dor, provocada pela ciática, pelo teste de incapacidade funcional que mensurava o tempo de elevação da pata (TEP do animal, e valores maiores que 10 segundos eram indicativos de dor. O TEP foi mensurado nos momentos: antes da lesão (M1

  2. Test and evaluation plan for Project W-314 tank farm restoration and safe operations

    International Nuclear Information System (INIS)

    Hays, W.H.

    1998-01-01

    The ''Tank Farm Restoration and Safe Operations'' (TFRSO), Project W-314 will restore and/or upgrade existing Hanford Tank Farm facilities and systems to ensure that the Tank Farm infrastructure will be able to support near term TWRS Privatization's waste feed delivery and disposal system and continue safe management of tank waste. The capital improvements provided by this project will increase the margin of safety for Tank Farms operations, and will aid in aligning affected Tank Farm systems with compliance requirements from applicable state, Federal, and local regulations. Secondary benefits will be realized subsequent to project completion in the form of reduced equipment down-time, reduced health and safety risks to workers, reduced operating and maintenance costs, and minimization of radioactive and/or hazardous material releases to the environment. The original regulatory (e.g., Executive Orders, WACS, CFRS, permit requirements, required engineering standards, etc.) and institutional (e.g., DOE Orders, Hanford procedures, etc.) requirements for Project W-314 were extracted from the TWRS S/RIDs during the development of the Functions and Requirements (F and Rs). The entire family of requirements were then validated for TWRS and Project W-314. This information was contained in the RDD-100 database and used to establish the original CDR. The Project Hanford Management Contract (PHMC) team recognizes that safety, quality, and cost effectiveness in the Test and Evaluation (T and E) program is achieved through a planned systematic approach to T and E activities. It is to this end that the Test and Evaluation Plan (TEP) is created. The TEP for the TFRSO Project, was developed based on the guidance in HNF-IP-0842, and the Good Practice Guide GPG-FM-005, ''Test and Evaluation,'' which is derived from DOE Order 430.1, ''Life Cycle Asset Management.'' It describes the Test and Evaluation program for the TFRSO project starting with the definitive design phase and ending

  3. Aerosolization, Chemical Characterization, Hygroscopicity and Ice Formation of Marine Biogenic Particles

    Science.gov (United States)

    Alpert, P. A.; Radway, J.; Kilthau, W.; Bothe, D.; Knopf, D. A.; Aller, J. Y.

    2013-12-01

    The oceans cover the majority of the earth's surface, host nearly half the total global primary productivity and are a major source of atmospheric aerosol particles. However, effects of biological activity on sea spray generation and composition, and subsequent cloud formation are not well understood. Our goal is to elucidate these effects which will be particularly important over nutrient rich seas, where microorganisms can reach concentrations of 10^9 per mL and along with transparent exopolymer particles (TEP) can become aerosolized. Here we report the results of mesocosm experiments in which bubbles were generated by two methods, either recirculating impinging water jets or glass frits, in natural or artificial seawater containing bacteria and unialgal cultures of three representative phytoplankton species, Thalassiosira pseudonana, Emiliania huxleyi, and Nannochloris atomus. Over time we followed the size distribution of aerosolized particles as well as their hygroscopicity, heterogeneous ice nucleation potential, and individual physical-chemical characteristics. Numbers of cells and the mass of dissolved and particulate organic carbon (DOC, POC), TEP (which includes polysaccharide-containing microgels and nanogels >0.4 μm in diameter) were determined in the bulk water, the surface microlayer, and aerosolized material. Aerosolized particles were also impacted onto substrates for ice nucleation and water uptake experiments, elemental analysis using computer controlled scanning electron microscopy and energy dispersive analysis of X-rays (CCSEM/EDX), and determination of carbon bonding with scanning transmission X-ray microscopy and near-edge X-ray absorption fine structure spectroscopy (STXM/NEXAFS). Regardless of bubble generation method, the overall concentration of aerosol particles, TEP, POC and DOC increased as concentrations of bacterial and phytoplankton cells increased, stabilized, and subsequently declined. Particles cloud formation and potential

  4. Seabed gallery intakes: Investigation of the water pretreatment effectiveness of the active layer using a long-term column experiment

    KAUST Repository

    Dehwah, Abdullah

    2017-05-11

    Seabed gallery intake systems used for seawater reverse osmosis facilities employ the same principle of water treatment as slow sand filtration in freshwater systems. An investigation concerning the effectiveness of the active layer (top layer) in improving raw water quality was conducted by using a long-term bench-scale columns experiment. Two different media types, silica and carbonate sand, were tested in 1 m columns to evaluate the effectiveness of media type in terms of algae, bacteria, Natural Organic Matter (NOM) and Transparent Exopolymer Particles (TEP) removal over a period of 620 days. Nearly all algae in the silica sand column, 87% (σ = 0.04) of the bacteria, 59% (σ = 0.11) of the biopolymer fraction of NOM, 59% (σ = 0.16) of particulate and 32% (σ = 0.25) of colloidal TEP were removed during the last 330 days of the experiment. Total removal was observed in the carbonate sand column for algal concentration, while the bacterial removal was lower at 74% (σ = 0.08). Removal of biopolymers, particulate and colloidal TEP were higher in the carbonate column during the last 330 days with 72% (σ = 0.15), 66% (σ = 0.08) and 36% (σ = 0.12) removed for these organics respectively. Removal of these key organics through the 1 m thick column, representing the active layer, will likely reduce the rate of biofouling, reduce chemical usage and minimize operating cost in SWRO systems. The data show that the media will require several months at the beginning of operation to reach equilibrium so that high organic removal rates can be achieved. No development of a “schmutzdecke” layer occurred. The experimental results suggest that unlike freshwater slow sand filtration wherein most water treatment occurs in the upper 10 cm, in seawater systems treatment occurs throughout the full active layer depth of 1 m. The results of this study will help in designing and operating seabed gallery intake systems in varied geological conditions.

  5. The Change of the Seebeck Coefficient Due to Neutron Irradiation and Thermal Fatigue of Nuclear Reactor Pressure Vessel Steel and its Application to the Monitoring of Material Degradation

    International Nuclear Information System (INIS)

    Niffenegger, M.; Reichlin, K.; Kalkhof, D.

    2002-05-01

    The monitoring of material degradation, that might be caused by neutron irradiation and thermal fatigue, is an important topic in lifetime extension of nuclear power plants. We therefore investigated the application of the Seebeck effect for determining material degradation of common reactor pressure vessel steel. The Seebeck coefficient (SC) of several irradiated Charpy specimens made from Japanese JRQ-steel were measured. The specimens suffered a fluence from 0 up to 4.5 x 10 19 neutrons per cm 2 with energies higher than 1 MeV. The measured changes of the SC within this range were about 500 nV, increasing continuously in the range under investigation. Some indications of saturation appeared at fluencies larger than 4.55 x 10 19 neutrons per cm 2 . We obtained a linear dependency between the SC and the temperature shift ΔT 41 of the Charpy-Energy- Temperature curve which is widely used to characterize material embrittlement. Similar measurements were performed on specimens made from the widely used austenitic steel X6CrNiTi18-10 (according to DIN 1.4541) that were fatigued by applying a cyclic strain amplitude of 0.28%. For this kind of fatigue the observed change of SC was somewhat smaller than for the irradiated specimens. Further investigations were made to quantify the size of the gage volume in which the thermoelectric power is generated. It appeared that the information gathered from a Thermo Electric Power (TEP) measurement is very local. To overcome this problem we propose a novel TEP-method using a Thermoelectric Scanning Microscope (TSM). We finally conclude that the change of the SC has a potential for monitoring of material degradation due to neutron irradiation and thermal fatigue, but it has to be taken into account that several influencing parameters could contribute to the TEP in either an additional or extinguishing manner. A disadvantage of the method is the requirement of a clean surface without any oxide layer. A part of this disadvantage can

  6. First record and impact of the crown-of-thorns starfish, Acanthaster planci (Spinulosida: Acanthasteridae on corals of Malpelo Island, Colombian Pacific

    Directory of Open Access Journals (Sweden)

    Krupskaya Narváez

    2010-05-01

    Full Text Available The crown-of-thorns starfish, Acanthaster planci, is a major coral predator widely distributed in the Indo-Pacific region, where population outbreaks have caused dramatic impacts on coral reefs. In the Tropical Eastern Pacific (TEP A. planci occurs at low population densities; it has been significantly abundant only in Panama and Cocos Island. We have recently found two individuals of A. planci at Malpelo Island, a small oceanic island with significant coral communities located off the Colombian Pacific coast. The recent discovery of A. planci at Malpelo is significant in light of recent reports of its increased frequency of observation at Cocos Island and occurrence at the Galapagos Islands. The individuals found at Malpelo have been repeatedly sighted since 2004, actively feeding on nine species of coral. Although densities of A. planci are low at Malpelo and other oceanic islands of the TEP, these islands may act as stepping stones for the colonization of other coral reef areas in the region. However, the low densities of A. planci suggest that it currently poses no threat to coral reefs in the TEP. Rev. Biol. Trop. 58 (Suppl. 1: 139-143. Epub 2010 May 01.La estrella de mar corona de espinas Acanthaster planci, es un importante depredador de coral ampliamente distribuido en la región del Indo-Pacifico, donde explosiones poblacionales han causado dramáticos impactos sobre los arrecifes coralinos. En el Pacifico Oriental Tropical (POT A. planci ocurre con densidades poblacionales bajas; solamente en Panamá e Isla de Cocos su abundancia ha sido significativa. Nosotros encontramos recientemente al menos dos individuos de A. planci en la Isla de Malpelo, una pequeña isla oceánica con comunidades coralinas importantes localizada en el Pacífico Colombiano. El hallazgo de A. planci en Malpelo es significativo a la luz de reportes recientes de un incremento en su frecuencia de observación en Isla de Cocos y su registro en Galápagos. Los

  7. The effectiveness of the implementation of new technologies in the prevention of purulent complications of repeated surgеries for complications of fractures of the proximal femur of patients

    Directory of Open Access Journals (Sweden)

    An. V. Kalashnikov

    2016-06-01

    Full Text Available Despite the latest achievements of modern traumatology, remains quite high percentage of unsatisfactory results of treatment of fractures of the proximal femur (fPf. According to the literature repeated surgery increases the risk of postoperative purulent complications in several times. The authors of the article developed the innovations introduced in practice based on the use of thrombocytopoiesis fibrin gel, which has a high antibacterial activity due to preservation of leukocytes (local antibiotic effect, together with bone shavings during the performing of the operations when performing reactioneze and TEP after performing osteosynthesis, and also at persons of senile and elderly, for prevention of postoperative purulent complications in fPf. A comprehensive clinical study of 120 patients with fPf complications (false joints, aseptic necrosis of the femoral head, axial deformation after osteomyelitis who underwent re-operative intervention was provided. Patients were divided into two groups, first (control group consisted of 60 patients with consequences fPf who underwent total endoprosthesis (TEP of the hip joint (30 patients and locked intramedullary nailing (LIN (30 patients by conventional methods. The second (experimental group consisted of 60 patients with consequences fPf who underwent TEP of the hip joint (30 patients and LIN (30 patients with use developed by authors of innovations. Effectiveness of prevention of septic complications in both groups of observation was evaluated. The observation period was 1 year. There was statistically significant (p≤0.01 decrease in the number of early (4 times and late (3 times postoperative complications in patients of the experimental group in comparison with patients of control group. The new technologies use allows to increase in 8.4% the efficiency of preventive maintenance of purulent complications of surgical treatment of patients with complications after performing osteosynthesis in the

  8. The effectiveness of the implementation of new technologies in the prevention of purulent complications of repeated surgеries for complications of fractures of the proximal femur of patients

    Directory of Open Access Journals (Sweden)

    An. V. Kalashnikov

    2016-06-01

    Full Text Available Despite the latest achievements of modern traumatology, remains quite high percentage of unsatisfactory results of treatment of fractures of the proximal femur (fPf. According to the literature repeated surgery increases the risk of postoperative purulent complications in several times. The authors of the article developed the innovations introduced in practice based on the use of thrombocytopoiesis fibrin gel, which has a high antibacterial activity due to preservation of leukocytes (local antibiotic effect, together with bone shavings during the performing of the operations when performing reactioneze and TEP after performing osteosynthesis, and also at persons of senile and elderly, for prevention of postoperative purulent complications in fPf. A comprehensive clinical study of 120 patients with fPf complications (false joints, aseptic necrosis of the femoral head, axial deformation after osteomyelitis who underwent re-operative intervention was provided. Patients were divided into two groups, first (control group consisted of 60 patients with consequences fPf who underwent total endoprosthesis (TEP of the hip joint (30 patients and locked intramedullary nailing (LIN (30 patients by conventional methods. The second (experimental group consisted of 60 patients with consequences fPf who underwent TEP of the hip joint (30 patients and LIN (30 patients with use developed by authors of innovations. Effectiveness of prevention of septic complications in both groups of observation was evaluated. The observation period was 1 year. There was statistically significant (p≤0.01 decrease in the number of early (4 times and late (3 times postoperative complications in patients of the experimental group in comparison with patients of control group. The new technologies use allows to increase in 8.4% the efficiency of preventive maintenance of purulent complications of surgical treatment of patients with complications after performing osteosynthesis in the

  9. Seabed gallery intakes: Investigation of the water pretreatment effectiveness of the active layer using a long-term column experiment.

    Science.gov (United States)

    Dehwah, Abdullah H A; Missimer, Thomas M

    2017-09-15

    Seabed gallery intake systems used for seawater reverse osmosis facilities employ the same principle of water treatment as slow sand filtration in freshwater systems. An investigation concerning the effectiveness of the active layer (top layer) in improving raw water quality was conducted by using a long-term bench-scale columns experiment. Two different media types, silica and carbonate sand, were tested in 1 m columns to evaluate the effectiveness of media type in terms of algae, bacteria, Natural Organic Matter (NOM) and Transparent Exopolymer Particles (TEP) removal over a period of 620 days. Nearly all algae in the silica sand column, 87% (σ = 0.04) of the bacteria, 59% (σ = 0.11) of the biopolymer fraction of NOM, 59% (σ = 0.16) of particulate and 32% (σ = 0.25) of colloidal TEP were removed during the last 330 days of the experiment. Total removal was observed in the carbonate sand column for algal concentration, while the bacterial removal was lower at 74% (σ = 0.08). Removal of biopolymers, particulate and colloidal TEP were higher in the carbonate column during the last 330 days with 72% (σ = 0.15), 66% (σ = 0.08) and 36% (σ = 0.12) removed for these organics respectively. Removal of these key organics through the 1 m thick column, representing the active layer, will likely reduce the rate of biofouling, reduce chemical usage and minimize operating cost in SWRO systems. The data show that the media will require several months at the beginning of operation to reach equilibrium so that high organic removal rates can be achieved. No development of a "schmutzdecke" layer occurred. The experimental results suggest that unlike freshwater slow sand filtration wherein most water treatment occurs in the upper 10 cm, in seawater systems treatment occurs throughout the full active layer depth of 1 m. The results of this study will help in designing and operating seabed gallery intake systems in varied geological conditions. Copyright

  10. Cloud Based Earth Observation Data Exploitation Platforms

    Science.gov (United States)

    Romeo, A.; Pinto, S.; Loekken, S.; Marin, A.

    2017-12-01

    In the last few years data produced daily by several private and public Earth Observation (EO) satellites reached the order of tens of Terabytes, representing for scientists and commercial application developers both a big opportunity for their exploitation and a challenge for their management. New IT technologies, such as Big Data and cloud computing, enable the creation of web-accessible data exploitation platforms, which offer to scientists and application developers the means to access and use EO data in a quick and cost effective way. RHEA Group is particularly active in this sector, supporting the European Space Agency (ESA) in the Exploitation Platforms (EP) initiative, developing technology to build multi cloud platforms for the processing and analysis of Earth Observation data, and collaborating with larger European initiatives such as the European Plate Observing System (EPOS) and the European Open Science Cloud (EOSC). An EP is a virtual workspace, providing a user community with access to (i) large volume of data, (ii) algorithm development and integration environment, (iii) processing software and services (e.g. toolboxes, visualization routines), (iv) computing resources, (v) collaboration tools (e.g. forums, wiki, etc.). When an EP is dedicated to a specific Theme, it becomes a Thematic Exploitation Platform (TEP). Currently, ESA has seven TEPs in a pre-operational phase dedicated to geo-hazards monitoring and prevention, costal zones, forestry areas, hydrology, polar regions, urban areas and food security. On the technology development side, solutions like the multi cloud EO data processing platform provides the technology to integrate ICT resources and EO data from different vendors in a single platform. In particular it offers (i) Multi-cloud data discovery, (ii) Multi-cloud data management and access and (iii) Multi-cloud application deployment. This platform has been demonstrated with the EGI Federated Cloud, Innovation Platform Testbed Poland

  11. An evaluation of Admedus' tissue engineering process-treated (ADAPT) bovine pericardium patch (CardioCel) for the repair of cardiac and vascular defects.

    Science.gov (United States)

    Strange, Geoff; Brizard, Christian; Karl, Tom R; Neethling, Leon

    2015-03-01

    Tissue engineers have been seeking the 'Holy Grail' solution to calcification and cytotoxicity of implanted tissue for decades. Tissues with all of the desired qualities for surgical repair of congenital heart disease (CHD) are lacking. An anti-calcification tissue engineering process (ADAPT TEP) has been developed and applied to bovine pericardium (BP) tissue (CardioCel, AdmedusRegen Pty Ltd, Perth, WA, Australia) to eliminate cytotoxicity, improve resistance to acute and chronic inflammation, reduce calcification and facilitate controlled tissue remodeling. Clinical data in pediatric patients, and additional pre-market authorized prescriber data demonstrate that CardioCel performs extremely well in the short term and is safe and effective for a range of congenital heart deformations. These data are supported by animal studies which have shown no more than normal physiologic levels of calcification, with good durability, biocompatibility and controlled healing.

  12. Amarillo MAP, Texas. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F.

    Science.gov (United States)

    1981-12-02

    ULL MONTHS FooM USAF ETAC JU 64 0-u-5 (OL A) - - - -- - - - - - - - - - - - -- - -- - -- - -- - - - - - - - - - I U S AIR FORCI ENVIRONOM1AL TECHICAL ...79, 84.0 85.1 85. 85. 85.2 85. 85.3 85o3 85.3 85.3 85.3 85.3 85.3 85.3 85.3 ? 80 0 86:. 86. 86. 11 . obo 871 87. 8?&1 8708.1W 870 8701 87.1 87.1 1200...PAGE 1 ObO -OBLC HO q .S. T. Tep. _ _ WET BULB TEMPERATURE DEPRESSION (F) . TOTAL TOTAL (F) 0 - 3. 4 5.6 7-8 19.10 .213 - 16!17. 18 19. 20121. 22123

  13. Fault Detection and Diagnosis in Process Data Using Support Vector Machines

    Directory of Open Access Journals (Sweden)

    Fang Wu

    2014-01-01

    Full Text Available For the complex industrial process, it has become increasingly challenging to effectively diagnose complicated faults. In this paper, a combined measure of the original Support Vector Machine (SVM and Principal Component Analysis (PCA is provided to carry out the fault classification, and compare its result with what is based on SVM-RFE (Recursive Feature Elimination method. RFE is used for feature extraction, and PCA is utilized to project the original data onto a lower dimensional space. PCA T2, SPE statistics, and original SVM are proposed to detect the faults. Some common faults of the Tennessee Eastman Process (TEP are analyzed in terms of the practical system and reflections of the dataset. PCA-SVM and SVM-RFE can effectively detect and diagnose these common faults. In RFE algorithm, all variables are decreasingly ordered according to their contributions. The classification accuracy rate is improved by choosing a reasonable number of features.

  14. Hamilton AFB, San Rafael, California. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A through F

    Science.gov (United States)

    1972-11-03

    1 .- U 732.n _ 1800 43.Z 57.2 61.4 64,8 68.1. 68.9 70.4 71.2 71.4 12.1 72𔃾 72.4 72.8 72.9 73 3 73,9 S150D0 $6 , 3. 6087. 71* 73al 74* 74. 9 . 1jj ll...OBSUVATIONS.f 2 ti e ~~USAF ETAC Aju6 0.14.5 (011) ooiwtesf[I G- 5 _ _ _ _ _ _ _ _ _ _ _ __w_ _ .4-’ ,’-% iie I , - td D 1ATA PROCESSING0 nDJSPJ EIIG VESS...YEARS MONTH PAGE 2 1200.e1400 Temp. OURS (L. S. Td Tep.WET BULB TEMPERATURE DEPRESSION (F) TOTAL -TOTAL F) 0 1. - 3-TT,5 67 - 87 9.-10 11 -12 13.-14 15

  15. Comportamiento bajo cargas estáticas de sistemas provisionales de protección de borde realizados con elementos de acero

    Directory of Open Access Journals (Sweden)

    González, M. N.

    2011-03-01

    Full Text Available The standard UNE-EN 13374 “Temporary edge protection systems. Product specification, test methods” (1 classifies the temporary edge protection systems (TEPS under three classes (A, B and C, based on the angle of the surface of work and the fall of the person to protect. The class A systems are the indicated when the inclination of the work surface is smaller than 10º. The standard establishes the requirements of deflection and strength of the TEPS. The requirements can be verified both analytically as experimentally. The aim of this work has been the evaluation of the behaviour of three TEPS class A –those commonly used in the construction works– and to establish the necessary changes so that they comply with the standard UNE-EN 13374. For it, three TEPS class A, made of steel S235, have been evaluated analytically and experimentally. The results obtained show that the system normally used in works does not comply with the requirements of the standard neither analytically nor experimentally. The third system fulfils the requirements with both methods of analysis. The second system surpasses the requirements when the evaluation is carried out analytically but not when it is performed experimentally.

    La norma UNE-EN 13374 “Sistemas provisionales de protección de borde. Especificaciones del producto, métodos de ensayo” (1 clasifica los sistemas provisionales de protección de borde (SPPB en tres clases (A, B y C, en función del ángulo de la superficie de trabajo y de la altura de caída de la persona a proteger. Los sistemas clase A son los indicados cuando la inclinación de la superficie de trabajo es menor de 10º. La norma establece los requisitos de flecha y de resistencia de los SPPB. Los requisitos se pueden comprobar tanto analítica como experimentalmente. El objetivo del trabajo ha sido la evaluación del comportamiento de los SPPB utilizados habitualmente en las obras y establecer los cambios necesarios para

  16. Peculiaridades da terapia trombolítica na síndrome nefrótica pediátrica: monitorização do fator anti-Xa Particularities of thrombolytic therapy in pediatric nephrotic syndrome: anti-factor Xa monitoring

    Directory of Open Access Journals (Sweden)

    Patrícia Zambi Meirelles

    2008-06-01

    Full Text Available OBJETIVO: Descrever a importância do tromboembolismo pulmonar (TEP na síndrome nefrótica pediátrica e o uso da heparina de baixo peso molecular como opção terapêutica segura e eficaz. DESCRIÇÃO DO CASO: Menino de 5,7 anos com síndrome nefrótica córtico-resistente e glomérulo-esclerose segmentar e focal foi internado devido à diarréia, distúrbios eletrolíticos e anasarca. No 11º dia de internação, evoluiu com desconforto respiratório súbito, cuja investigação mostrou área de alta probabilidade de TEP na cintilografia pulmonar ventilação/perfusão e obstrução em veia jugular interna esquerda ao ultra-som doppler. Iniciado suporte ventilatório com nebulização de oxigênio e anticoagulação com enoxaparina (2mg/kg/dia. Após seis dias, evoluiu com sintomas neurológicos compatíveis com episódio isquêmico transitório, sem alteração na tomografia computadorizada de crânio. A monitorização do fator anti-Xa no soro demonstrou nível subterapêutico e a dose de enoxaparina foi ajustada para 3mg/kg/dia. O edema e os sintomas pulmonares melhoraram e o paciente recebeu alta hospitalar após 33 dias. COMENTÁRIOS: Embora o TEP seja raro em crianças, a síndrome nefrótica é uma condição pró-trombótica que favorece a complicação. A heparina de baixo peso molecular pode ser considerada no tratamento e na profilaxia secundária do TEP, sendo importante monitorizar o nível sérico do fator anti-Xa para ajustar sua dose e promover tratamento seguro e eficaz.OBJECTIVE: Report the importance of pulmonary thromboembolism (PTE in pediatric nephrotic syndrome and the use of low molecular weight heparin (LMWH as an effective and secure therapeutic option. CASE DESCRIPTION: A 5.7 year-old boy with steroid-resistant nephrotic syndrome and focal segmental glomerulosclerosis was admitted to the pediatric unit with diarrhea, electrolyte disturbances and anasarca. On the 11th day of hospital stay, he developed a sudden

  17. Media education perspectives with multimedia resources

    Directory of Open Access Journals (Sweden)

    Jaime Gabriel Espinosa Izquierdo

    2016-08-01

    Full Text Available It is indisputable that today’s society has undergone changes in this decade, related to technological and educational advances. This has created the new era of knowledge for changing from analog to digital era, this has created the birth of new tools to improve the teaching and learning process where the teacher is the protagonist of these changes for secondary education, the which it has had major transformations for the rapid development of information technology and communications (ICT; to be implemented in the training process of prospective students, that is where the concept of learning technologies and knowledge (TAC and technologies for empowerment and participation (TEP appears; constituting them in educational tools necessary for the teaching-learning process of education.

  18. The importance of circulating tumor products as „liquid biopsies” in colorectal cancer

    Directory of Open Access Journals (Sweden)

    Alina Miscoci

    2018-04-01

    Full Text Available Liquid biopsies represent an array of plasma analysis tests that are studied to evaluate and identify circulating tumor products, especially circulating tumor cells (CTCs and circulating tumor DNA (ctDNA. Examining such biomarkers in the plasma of colorectal cancer patients has attracted attention due to its clinical significance in the treatment of malignant diseases. Given that tissue samples are sometimes challenging to procure or unsatisfactory for genomic profiling from patients with colorectal cancer, trustworthy biomarkers are mandatory for guiding treatment, monitoring therapeutic response, and detecting recurrence. This review considers the relevance of flowing tumor products like circulating tumor cells (CTCs, circulating tumor DNA (ctDNA, circulating messenger RNA (mRNA, circulating micro RNA (miRNA, circulating exosomes, and tumor educated platelets (TEPs for patients with colorectal cancer.

  19. Applications of nucleoside-based molecular probes for the in vivo assessment of tumour biochemistry using positron emission tomography (PET

    Directory of Open Access Journals (Sweden)

    Leonard I. Wiebe

    2007-05-01

    Full Text Available Positron emission tomography (PET is a non-invasive nuclear imaging technique. In PET, radiolabelled molecules decay by positron emission. The gamma rays resulting from positron annihilation are detected in coincidence and mapped to produce three dimensional images of radiotracer distribution in the body. Molecular imaging with PET refers to the use of positron-emitting biomolecules that are highly specific substrates for target enzymes, transport proteins or receptor proteins. Molecular imaging with PET produces spatial and temporal maps of the target-related processes. Molecular imaging is an important analytical tool in diagnostic medical imaging, therapy monitoring and the development of new drugs. Molecular imaging has its roots in molecular biology. Originally, molecular biology meant the biology of gene expression, but now molecular biology broadly encompasses the macromolecular biology and biochemistry of proteins, complex carbohydrates and nucleic acids. To date, molecular imaging has focused primarily on proteins, with emphasis on monoclonal antibodies and their derivative forms, small-molecule enzyme substrates and components of cell membranes, including transporters and transmembrane signalling elements. This overview provides an introduction to nucleosides, nucleotides and nucleic acids in the context of molecular imaging.A tomografia por emissão de pósitrons (TEP é uma técnica de imagem não invasiva da medicina nuclear. A TEP utiliza moléculas marcadas com emissores de radiação beta positiva (pósitrons. As radiações gama medidas que resultam do aniquilamento dos pósitrons são detectadas por um sistema de coincidência e mapeadas para produzir uma imagem tridimensional da distribuição do radiotraçador no corpo. A imagem molecular com TEP refere-se ao uso de biomoléculas marcadas com emissor de pósitron que são substratos altamente específicos para alvos como enzimas, proteínas transportadoras ou receptores prot

  20. Positron emission tomography using 18fluorodeoxyglucose and tumors markers

    International Nuclear Information System (INIS)

    Lamy, P.J.; Grenier, J.

    2004-01-01

    Tumor cells present different characteristics that are used to diagnosis metastasis. Tumor markers are substances that can often be detected in higher-than-normal amounts in the blood, urine, or body tissues of some patients with certain types of cancer. The main use of tumor markers is to assess a cancer's response to treatment and to check for recurrence. Less than 20 % of the initial rises of tumor marker is accompanied with clinical events or radiological signs. TEP using 18 FDG allows metastasis detection at early stage. Tumor markers as tools to monitor recurrence can help to select the patients who need a TER. These two diagnostic ways, used together, should improve patients follow-up. (author)

  1. A multi-objective framework for dynamic transmission expansion planning in competitive electricity market

    International Nuclear Information System (INIS)

    Foroud, Asghar Akbari; Abdoos, Ali Akbar; Keypour, Reza; Amirahmadi, Meisam

    2010-01-01

    Restructuring of power system has changed the traditional planning objectives and introduced challenges in the field of Transmission Expansion Planning (TEP). Due to these changes, new approaches and criteria are needed for transmission planning in deregulated environment. Therefore, in this paper, a dynamic expansion methodology is presented using a multi-objective optimization framework. Investment cost, congestion cost and reliability are considered in the optimization as three objectives. To overcome the difficulties in solving the non-convex and mixed integer nature of the optimization problems, a Non-Dominated Sorting Genetic Algorithm (NSGA II) approach is used followed by a fuzzy decision making analysis to obtain the final optimal solution. The planning methodology has been demonstrated on the IEEE 24-bus test system and north-east of Iran national 400 kV transmission grid to show the feasibility and capabilities of the proposed algorithm in electricity market environment. (author)

  2. Algeria; Algerie

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2003-04-01

    Algeria disposes of important fossil energy reserves: 4250 Gm{sup 3} for natural gas and 1300 Mt for oil. Algeria has developed a large capacity of refining on 4 sites: 502700 barrels a day. In 2001 the production reached 67 Mt for crude oil and 32 Mt for oil by-products. The same year the exports reached 36 Mt for liquid hydrocarbons and 21 Mt for oil by-products. In 2001 the production of natural gas reached 79 Gm{sup 3} of which about 78 % were exported (58 Gm{sup 3}). The main clients are Italy (46 %), Spain (18 %), France (18 %), Tunisia (7 %), Belgium (4 %) and Portugal (4 %). Algeria has a low level of energy consumption: 0,8 Tep (equivalent ton of oil) per inhabitant and 670 kWh/inhabitant for electricity. (A.C.)

  3. Exploration of the short-term and long-term effects of parental illness on children's educational and behavioral functioning using a large Taiwanese sample.

    Science.gov (United States)

    Chen, Yung-Chi

    2014-05-01

    This study used data from Waves I and II of the Taiwan Educational Panel Survey (TEPS) to explore the potential short-term and long-term effects of parental illness and health condition on children's behavioral and educational functioning. A sample of 11,018 junior high school students and their parents and teachers in Taiwan were included in this present study. The results supported previous work that parental illness may place children at slight risk for poor psychosocial adjustment and behavioral problems. Parental illness was associated with lower adaptive skills and more behavioral problems in children. Children of ill parents showed resilience in their educational functioning in the event of parental illness as children's academic achievement and learning skills were not related to parental illness/health condition.

  4. Beta-ethoxyacrolein contamination increases malondialdehyde inhibition of milk xanthine oxidase activity.

    Science.gov (United States)

    Cighetti, G; Debiasi, S; Ciuffreda, P; Allevi, P

    1998-11-01

    beta-Ethoxyacrolein (BEA), a side product that forms during the preparation of malondialdehyde (MDA) by acidic hydrolysis of tetraethoxypropane (TEP), has been found to be an inhibitor of milk xanthine oxidase (XO) several times more potent than pure MDA (NaMDA). The incubation of XO with 10 microM BEA abolished 50% of the enzyme activity within 1 min; the inhibited enzyme was totally regenerated by dialysis and filtration through Sephadex. The BEA inhibition mode of the enzyme was mixed-type with the apparent inhibition constants (Ki) of 2.4 x 10(-6) M. An HPLC method for quantitation of BEA in the crude commonly used MDA preparation was set up.

  5. Cosmological Implications of a Solid Upper Mass Limit Placed on DFSZ Axions Thanks to Pulsating White Dwarfs

    Science.gov (United States)

    Kim, A.; Montgomery, M. H.; Winget, D. E.

    2006-09-01

    Axions are theoretical particles that provide an elegant solution to the strong CP problem in the Standard Model of particle physics. In addition, they are potential dark matter candidates. The problem is that the theory of axions does not really constrain their mass, and axions can only account for dark matter if they have the right mass. Several searches are underway that try to find axions and/or constrain their mass. With pulsating white dwarfs, we can place a solid upper limit on the mass of DFSZ axions (a model for axions that interact with electrons, tep{dfsz}). We present how this can be done and how it can be improved. We then try to see if we can draw any conclusion about axions as dark matter candidates by looking at the different cosmological models of their formation in the early universe.

  6. Fault detection of Tennessee Eastman process based on topological features and SVM

    Science.gov (United States)

    Zhao, Huiyang; Hu, Yanzhu; Ai, Xinbo; Hu, Yu; Meng, Zhen

    2018-03-01

    Fault detection in industrial process is a popular research topic. Although the distributed control system(DCS) has been introduced to monitor the state of industrial process, it still cannot satisfy all the requirements for fault detection of all the industrial systems. In this paper, we proposed a novel method based on topological features and support vector machine(SVM), for fault detection of industrial process. The proposed method takes global information of measured variables into account by complex network model and predicts whether a system has generated some faults or not by SVM. The proposed method can be divided into four steps, i.e. network construction, network analysis, model training and model testing respectively. Finally, we apply the model to Tennessee Eastman process(TEP). The results show that this method works well and can be a useful supplement for fault detection of industrial process.

  7. Analytical developments and preliminary assessment of human exposure to organophosphate flame retardants from indoor dust.

    Science.gov (United States)

    Van den Eede, Nele; Dirtu, Alin C; Neels, Hugo; Covaci, Adrian

    2011-02-01

    A new and efficient analytical method was developed and validated for the analysis of organophosphorus flame retardants (OPFRs) in indoor dust samples. This method involves an extraction step by ultrasonication and vortex, followed by extract clean-up with Florisil solid-phase extraction cartridges and analysis of the purified extracts by gas chromatography-mass spectrometry (GC-MS). Method recoveries ranged between 76 and 127%, except for volatile OPFRs, such as triethyl phosphate (TEP) and tri-(n-propyl) phosphate (TnPP), which were partially lost during evaporation steps. The between day precision on spiked dust samples was TDCPP) was increased by a factor >5. Copyright © 2010 Elsevier Ltd. All rights reserved.

  8. [Report from the Committee for Advanced Therapies (CAT). Pitfalls on the way from concept to medical treatment with advanced therapy medicinal products].

    Science.gov (United States)

    Reiss, M; Büttel, I C; Schneider, C K

    2011-07-01

    Advanced therapy medicinal products (ATMP) are highly innovative and complex medicines. They comprise gene therapy medicinal products, somatic cell therapy medicinal products, and tissue-engineered products (TEP). With the European Regulation on ATMP that came into force in 2008, a consolidated regulatory framework was created, where the Committee for Advanced Therapies (CAT) at the European Medicines Agency (EMA) plays a central role. This article discusses pitfalls and challenges that the CAT has experienced in its discussions of various procedures. Often ATMPs are developed by small and medium-sized enterprises (SME) which also face nonscientific challenges. The CAT wishes to meet these challenges on a scientific and regulatory level during its 2010-2015 work program.

  9. Neodymium Catalyst for the Polymerization of Dienes and Polar Vinyl Monomers.

    Science.gov (United States)

    Kularatne, Ruvanthi N; Yang, Annie; Nguyen, Hien Q; McCandless, Gregory T; Stefan, Mihaela C

    2017-10-01

    Ziegler-Natta catalysts have played a major role in industry for the polymerization of dienes and vinyl monomers. However, due to the deactivation of the catalyst, this system fails to polymerize polar vinyl monomers such as vinyl acetate, methyl methacrylate, and methyl acrylate. Herein, a catalytic system composed of NdCl 3 ⋅3TEP/TIBA is reported, which promotes a quasi-living polymerization of dienes and is also active for the homopolymerization of polar vinyl monomers. Additionally, this catalytic system generates polymyrcene-b-polyisoprene and poly(myrcene)-b-poly(methyl methacrylate) diblock copolymers by sequential monomer addition. To encourage the replacement of petroleum-based polymers by environmentally benign biobased polymers, polymerization of β-myrcene is demonstrated with a catalytic activity of ≈106 kg polymer mol Nd -1 h -1 . © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Feasibility Study for Paragon - Bisti Solar Ranch

    Energy Technology Data Exchange (ETDEWEB)

    Benally, Thomas [Navajo Hopi Land Commission Office (NHLCO), Window Rock, AZ (United States)

    2015-06-01

    The Navajo Hopi Land Commission Office (NHLCO) and Navajo Nation (NN) plan to develop renewable energy (RE) projects on the Paragon-Bisti Ranch (PBR) lands, set aside under the Navajo Hopi Land Settlement Act (NHLSA) for the benefit of Relocatees. This feasibility study (FS), which was funded under a grant from DOE’s Tribal Energy Program (TEP), was prepared in order to explore the development of the 22,000-acre PBR in northwestern New Mexico for solar energy facilities. Topics covered include: • Site Selection • Analysis of RE, and a Preliminary Design • Transmission, Interconnection Concerns and Export Markets • Financial and Economic Analysis • Environmental Study • Socioeconomic and Cultural Factors • Next Steps.

  11. Features of the survey of heat consumption in the development of a comprehensive plan for energy efficiency institution of higher education

    Directory of Open Access Journals (Sweden)

    Lagereva E.A.

    2016-06-01

    Full Text Available The methodology of the survey of heat consumption in the development of a comprehensive plan for energy conserva-tion educational institutions of higher education. The results of field studies of heat consumption one of the educational institutions of the city of Bryansk. The survey was done study of the temperature and humidity and an air regimen of locations, a thermographic survey of the exterior enclosures of buildings, the analysis of the data of heat meters. Built valid temperature charts of the surveyed buildings, obtained by processing the experimental data using the least squares method. Graphs of actual and theoretical costs of TEP-lots daily during the whole heating period. Propose concrete actions, allowing to increase the efficiency of the heating system of the educational institution.

  12. Electronic structures of actinyl nitrate-triethyl phosphate complexes using the DV-DS method

    International Nuclear Information System (INIS)

    Hirata, M.; Tachimori, S.; Sekine, R.; Onoe, J.; Takeuchi, K.; Nakamatsu, H.; Mukoyama, T.

    1998-01-01

    Electronic structures of actinyl nitrate-triethyl phosphate complexes (AnO 2 (NO 3 ) 2 .2TEP; An=U, Np, Pu) have been studied, using the relativistic discrete-variational Dirac-Slater molecular orbital method. On the extraction behavior of hexavalent actinyl nitrates, it is known that the distribution ratio decreases in the order U>Np>Pu when neutral organophosphorous agents are used as extractants. To elucidate this variation, the bonding nature between the actinide atom and the donor oxygen atom is examined. It is found that the extractability of the organophosphorous agents decrease with decreasing bond overlap population between the actinide atom and the donor oxygen atom of the extractant. (orig.)

  13. Review of the State-of-the-Art in Power Electronics Suitable for 10-KW Military Power Systems

    Energy Technology Data Exchange (ETDEWEB)

    Staunton, R.H.

    2003-12-19

    The purpose of this report is to document the technological opportunities of integrating power electronics-based inverters into a TEP system, primarily in the 10-kW size range. The proposed enhancement offers potential advantages in weight reduction, improved efficiency, better performance in a wider range of generator operating conditions, greater versatility and adaptability, and adequate reliability. In order to obtain strong assurance of the availability of inverters that meet required performance and reliability levels, a market survey was performed. The survey obtained positive responses from several manufacturers in the motor drive and distributed generation industries. This study also includes technology reviews and assessments relating to circuit topologies, reliability issues, vulnerability to pulses of electromagnetic energy, potential improvements in semiconductor materials, and potential performance improvement through cryogenics.

  14. Sedimentation of phytoplankton during a diatom bloom : Rates and mechanisms

    DEFF Research Database (Denmark)

    Kiørboe, Thomas; Hansen, J.L.S.; Alldredge, A.L.

    1996-01-01

    velocities, settling of cells attached to marine snow aggregates formed from discarded larvacean houses or pteropod feeding webs, and packaging of cells into rapidly falling zooplankton fecal pellets. We quantified the relative significance of these different mechanisms during a diatom bloom in a temperate...... recorded in the water column (by divers) nor in sediment traps. The low coagulation rates were due to a very low 'stickiness' of suspended particles. The dominant diatom, Thalassiosira mendiolana, that accounted for up to 75% of the phytoplankton biomass, was not sticky at al, and did not turn sticky upon...... nutrient depletion in culture experiments. The low particle stickiness recorded may be related to low formation rates by diatoms of transparent exopolymeric particles (TEP), that occurred in low concentrations throughout the study period. Zooplankton grazing rate did not respond to the development...

  15. Ultra-som terapêutico contínuo térmico em modelo experimental de ciatalgia Continuous thermic therapeutic ultrasound in sciatica experimental model

    Directory of Open Access Journals (Sweden)

    Adriano Polican Ciena

    2009-06-01

    Full Text Available O ultra-som é um recurso fisioterapêutico que pode atuar na redução dos sintomas da ciatalgia. O objetivo deste estudo foi verificar a eficácia do ultra-som terapêutico, no modo contínuo, em duas diferentes densidades de potência (0,5 W/cm² e 1 W/cm², na redução do quadro álgico em ratos submetidos a modelo experimental de ciatalgia. Foram utilizados 20 ratos, divididos em 3 grupos: G1 (n=6 submetido à ciatalgia e a tratamento placebo; G2 (n=7 submetido à ciatalgia e tratado com ultra-som com 0,5 W/cm²; e G3 (n=7 submetido à ciatalgia e tratado com ultra-som com 1 W/cm². A ciatalgia foi provocada por lesão cirúrgica de compressão do nervo no membro posterior direito de todos os animais. O tratamento na região do procedimento cirúrgico, iniciado no 3º dia pós-operatório, consistiu em 10 sessões diárias de 5 minutos. Verificou-se a dor pelo do tempo de elevação da pata (TEP durante a marcha, medido pré-cirurgia e em mais cinco momentos. Os resultados mostram aumentos no TEP em todos os grupos após a lesão; e, naqueles tratados com ultra-som terapêutico, houve diminuição significativa da TEP, restaurando-se os valores iniciais, sendo mais precoce e intensa em G2. Conclui-se que a entrega na forma continua do ultra-som terapêutico foi eficaz na redução da dor ciática.Therapeutic ultrasound is a physical therapy resource for relieving sciatic pain. The aim of this study was to assess the effectiveness of continuous therapeutic ultrasound in two different power densities (0,5 W/cm² and 1 W/cm², on reducing pain in rats submitted to a sciatica experimental model. Twenty rats were used, divided into 3 groups: G1 (n=6 submitted to sciatica and placebo treatment; G2 (n=7 submitted to sciatica and treated with 0.5 W/cm² ultrasound; and G3 (n=7, submitted to sciatica and treated with 1 W/cm² ultrasound. Sciatica was provoked by surgical nerve compression on the right posterior limb of all animals. Treatment on the

  16. Project W-314 specific test and evaluation plan for SN-635 transfer line (241-AY-01A to 241-AY-02A) and SN-633 transfer line tie in

    International Nuclear Information System (INIS)

    Hays, W.H.

    1998-01-01

    This Specific Test and Evaluation Plan (STEP) defines the test and evaluation activities encompassing the installation of the SN-635 transfer line for the W-314 Project. The purpose of this Specific Test and Evaluation Plan (STEP) is to provide a detailed written plan for the systematic testing of modifications made by the addition of the SN-635 transfer line and the tie in of SN-633 to the AY-02A pit by the W-314 Project. The STEP develops the outline for test procedures that verify the system's performance to the established Project design criteria. The STEP is a lower tier document based on the W-314 Test and Evaluation Plan (TEP)

  17. Application of electrochemical processes to membrane bioreactors for improving nutrient removal and fouling control.

    Science.gov (United States)

    Borea, Laura; Naddeo, Vincenzo; Belgiorno, Vincenzo

    2017-01-01

    Membrane bioreactor (MBR) technology is becoming increasingly popular as wastewater treatment due to the unique advantages it offers. However, membrane fouling is being given a great deal of attention so as to improve the performance of this type of technology. Recent studies have proven that the application of electrochemical processes to MBR represents a promising technological approach for membrane fouling control. In this work, two intermittent voltage gradients of 1 and 3 V/cm were applied between two cylindrical perforated electrodes, immersed around a membrane module, at laboratory scale with the aim of investigating the treatment performance and membrane fouling formation. For comparison purposes, the reactor also operated as a conventional MBR. Mechanisms of nutrient removal were studied and membrane fouling formation evaluated in terms of transmembrane pressure variation over time and sludge relative hydrophobicity. Furthermore, the impact of electrochemical processes on transparent exopolymeric particles (TEP), proposed as a new membrane fouling precursor, was investigated in addition to conventional fouling precursors such as bound extracellular polymeric substances (bEPS) and soluble microbial products (SMP). All the results indicate that the integration of electrochemical processes into a MBR has the advantage of improving the treatment performance especially in terms of nutrient removal, with an enhancement of orthophosphate (PO 4 -P) and ammonia nitrogen (NH 4 -N) removal efficiencies up to 96.06 and 69.34 %, respectively. A reduction of membrane fouling was also observed with an increase of floc hydrophobicity to 71.72 %, a decrease of membrane fouling precursor concentrations, and, thus, of membrane fouling rates up to 54.33 %. The relationship found between TEP concentration and membrane fouling rate after the application of electrochemical processes confirms the applicability of this parameter as a new membrane fouling indicator.

  18. Lime and Zn interactions effects on yield, yield component, and quality of rice in Zn deficit tropical paddy soil

    Directory of Open Access Journals (Sweden)

    Shahram Mahmoud Soltani

    2017-10-01

    Full Text Available A glasshouse experiment was conducted to investigate the lime and Zn application and interactions on rice, yield and yield components, and rice quality in various Zn deficit tropical paddy soil types. The tiller number, plant height and straw dry matter at maximum tillering and flowering stages significantly increased by the application of lime and both at 5 and 10 kg ha-1 Zn levels in Kundur (KUR (pH= 5.2 and Telemong (TLM (pH=7 soil series, whereas in Tepus (TEP acid sulphate soil (pH=4, they increased in 5 kg ha-1 Zn and decrease at 10 kg ha-1. The grain per panicle(GPP, grain yield(GY, 1000grain weight(1000GW and straw dry matter(SDW significantly increased by application of Zn and increasing its levels. The highest increasing pattern were showed in Kundur (pH= 5.2 and Telemong (pH=7 soil series were recorded at 10 kg ha-1, whereas the highest and lowest values were obtained at 5 kg ha-1 and at 10 kg ha-1 in Tepus acid sulphate soil (pH=4. The highest grain and straw yield were obtained in TEP at 5 kg ha-1Zn level, which were 56 and 23% more than untreated Zn pots. The highest crude protein (CP and grain Zn (GZn were observed by 10 kg ha-1 applied Zn, 44% and 60% more than control, respectively. However, by lime addition CP and GZn decreased about 16 and 22% over the non-treated plots. The agronomic biofortification strategies such as Zn fertilization application and soil amendment addition improved rice MR219grain productivity and biofortification an average of 60%.

  19. Integrated resource planning in the power sector and economy-wide changes in environmental emissions

    Energy Technology Data Exchange (ETDEWEB)

    Shrestha, Ram M. [Asian Inst. of Technology, School of Environment, Resources and Development, Pathumthani (Thailand); Marpaung, Charles O.P. [Christian Univ. of Indonesia, Dept. of Electrical Engineering, Jakarta (Indonesia)

    2006-12-15

    This paper analyzes the roles of key factors (i.e., changes in structure, fuel mix and final demand) on total economy-wide changes in CO{sub 2}, SO{sub 2} and NO{sub x} emissions when power sector development follows the integrated resource planning (IRP) approach instead of traditional supply-based electricity planning (TEP). It also considers the rebound effect (RE) of energy efficiency improvements in the demand side and analyzes the sensitivity of the results to variations in the values of the RE. A framework is developed to decompose the total economy-wide change in the emission of a pollutant into four major components, i.e., structural change-, fuel mix- , final demand- and joint-effects. The final demand effect is further decomposed into three categories, i.e., construction of power plants, electricity final demand and final demand related to electricity using equipment. The factor decomposition framework is then applied in the case of the power sector in Indonesia. A key finding in the case of Indonesia is that in the absence of the RE, there would be total economy-wide reductions in CO{sub 2}, SO{sub 2} and NO{sub x} emissions of 431, 1.6 and 1.3 million tons respectively during the planning horizon of 2006-2025 under IRP as compared to that under TEP. The decomposition analysis shows that the final demand effect would account for 38% of the total CO{sub 2} emission reduction followed by the structural change effect (35.1%) and fuel mix effect (27.6%) while the joint effect is negligible. The study also shows that economy-wide CO{sub 2} emission reduction due to IRP considering the RE of 45% would be 241 million tons as compared to 333 million tons when the RE is 25%. (Author)

  20. Insights on the neural basis of motor plasticity induced by theta burst stimulation from TMS-EEG

    Science.gov (United States)

    VERNET, Marine; BASHIR, Shahid; YOO, Woo-Kyoung; PEREZ, Jennifer M.; NAJIB, Umer; PASCUAL-LEONE, Alvaro

    2014-01-01

    Transcranial magnetic stimulation (TMS) is a useful tool to induce and measure plasticity in the human brain. However, the cortical effects are generally indirectly evaluated with motor-evoked potentials (MEPs) reflective of modulation of cortico-spinal excitability. In this study, we aim to provide direct measures of cortical plasticity by combining TMS with electroencephalography (EEG). Continuous theta-burst stimulation (cTBS) was applied over the primary motor cortex (M1) of young healthy adults; and we measured modulation of (i) motor evoked-potentials (MEPs), (ii) TMS-induced EEG evoked potentials (TEPs), (iii) TMS-induced EEG synchronization and (iv) eyes-closed resting EEG. Our results show the expected cTBS-induced decrease in MEPs size, which we found to be paralleled by a modulation of a combination of TEPs. Furthermore, we found that cTBS increased the power in the theta band of eyes-closed resting EEG, whereas it decreased single-pulse TMS-induced power in the theta and alpha bands. In addition, cTBS decreased the power in the beta band of eyes-closed resting EEG, whereas it increased single-pulse TMS-induced power in the beta band. We suggest that cTBS acts by modulating the phase alignment between already active oscillators; it synchronizes low frequency (theta and/or alpha) oscillators and desynchronizes high frequency (beta) oscillators. These results provide novel insights into the cortical effects of cTBS and could be useful for exploring cTBS-induced plasticity outside of the motor cortex. PMID:23190020

  1. Is transverse abdominis plane block effective following local anesthetic infiltration in laparoscopic totally extraperitoneal hernia repair?

    Science.gov (United States)

    Kim, Mun Gyu; Kim, Soon Im; Ok, Si Young; Kim, Sang Ho; Lee, Se-Jin; Park, Sun Young; Yoo, Jae-Hwa; Cho, Ana; Hur, Kyung Yul; Kim, Myung Jin

    2014-12-01

    Transverse abdominis plane (TAP) block can be recommended as a multimodal method to reduce postoperative pain in laparoscopic abdominal surgery. However, it is unclear whether TAP block following local anesthetic infiltration is effective. We planned this study to evaluate the effectiveness of the latter technique in laparoscopic totally extraperitoneal hernia repair (TEP). We randomly divided patients into two groups: the control group (n = 37) and TAP group (n = 37). Following the induction of general anesthesia, as a preemptive method, all of the patients were subjected to local anesthetic infiltration at the trocar sites, and the TAP group was subjected to ultrasound-guided bilateral TAP block with 30 ml of 0.375% ropivacaine in addition before TEP. Pain was assessed in the recovery room and post-surgery at 4, 8, and 24 h. Additionally, during the postoperative 24 h, the total injected dose of analgesics and incidence of nausea were recorded. On arrival in the recovery room, the pain score of the TAP group (4.33 ± 1.83) was found to be significantly lower than that of the control group (5.73 ± 2.04). However, the pain score was not significantly different between the TAP group and control group at 4, 8, and 24 h post-surgery. The total amounts of analgesics used in the TAP group were significantly less than in the control group. No significant difference was found in the incidence of nausea between the two groups. TAP block following local infiltration had a clinical advantage only in the recovery room.

  2. Fração tardia do espaço morto (fDlate antes e após embolectomia pulmonar Late dead space fraction (fDlate before and after pulmonary embolectomy

    Directory of Open Access Journals (Sweden)

    Marcos Mello Moreira

    2005-03-01

    Full Text Available Este relato de caso apresenta os resultados da fDlate (fração tardia de espaço morto em um paciente submetido a embolectomia por tromboembolismo pulmonar (TEP. O TEP foi diagnosticado por ultrassonografia ecodoppler de membros inferiores, cintilografia pulmonar, tomografia helicoidal computadorizada e arteriografia pulmonar. O cálculo da fDlate se baseou na capnografia volumétrica e na gasometria arterial de acordo com ERIKSSON et al. [1]. A fDlate pré-operatória foi de 0,16 e foi considerada positiva por estar acima do valor de corte de 0,12. A fDlate pós-operatória foi de - 0,04, um valor inferior ao valor de corte de 0,12 e foi caracterizada como negativa. A correlação da fDlate com os resultados de imagem confirma a validade desta nova ferramenta diagnóstica não-invasiva.This report presents data on the late dead space fraction (fDlate of a patient submitted to surgical pulmonary embolectomy. Pulmonary thromboembolism (PTE was diagnosed by echo-Doppler ultrasound of the lower limbs, lung scintigraphy, computerized helical tomography and angiography. The fDlate was calculated based on volumetric capnography as well as on arterial blood gases according to ERIKSSON et al. [1]. The preoperative fDlate value was 0.16, which was considered positive for the diagnosis of PTE, as it was higher than the cut-off point of 0.12. The postoperative fDlate value was - 0.04, which was below 0.12 and was characterized as negative. The agreement of fDlate with the imaging results confirms the validity of this new, noninvasive diagnostic tool.

  3. Implementing model-based system engineering for the whole lifecycle of a spacecraft

    Science.gov (United States)

    Fischer, P. M.; Lüdtke, D.; Lange, C.; Roshani, F.-C.; Dannemann, F.; Gerndt, A.

    2017-09-01

    Design information of a spacecraft is collected over all phases in the lifecycle of a project. A lot of this information is exchanged between different engineering tasks and business processes. In some lifecycle phases, model-based system engineering (MBSE) has introduced system models and databases that help to organize such information and to keep it consistent for everyone. Nevertheless, none of the existing databases approached the whole lifecycle yet. Virtual Satellite is the MBSE database developed at DLR. It has been used for quite some time in Phase A studies and is currently extended for implementing it in the whole lifecycle of spacecraft projects. Since it is unforeseeable which future use cases such a database needs to support in all these different projects, the underlying data model has to provide tailoring and extension mechanisms to its conceptual data model (CDM). This paper explains the mechanisms as they are implemented in Virtual Satellite, which enables extending the CDM along the project without corrupting already stored information. As an upcoming major use case, Virtual Satellite will be implemented as MBSE tool in the S2TEP project. This project provides a new satellite bus for internal research and several different payload missions in the future. This paper explains how Virtual Satellite will be used to manage configuration control problems associated with such a multi-mission platform. It discusses how the S2TEP project starts using the software for collecting the first design information from concurrent engineering studies, then making use of the extension mechanisms of the CDM to introduce further information artefacts such as functional electrical architecture, thus linking more and more processes into an integrated MBSE approach.

  4. Liquid chromatography-tandem mass spectrometry direct injection analysis of organophosphorus flame retardants in Ontario surface water and wastewater effluent.

    Science.gov (United States)

    Hao, Chunyan; Helm, Paul A; Morse, David; Reiner, Eric J

    2018-01-01

    Organophosphorus flame retardants (OPFRs) started to be used in plastics, electronics and furnishings back in the 1960s and became popular again last decade. They are now widely present in the environment and regarded as "new" emerging organic pollutants. An effective liquid chromatography-tandem mass spectrometry (LC-MS/MS) direct injection analysis (DIA) method was developed to monitor OPFR levels in aquatic environment. The removal of sample extraction and concentration steps not only improved operation efficiency, but also reduced the potential contamination commonly observed during the sample preparation process before. Positive background signals from the analytical instrument were eliminated by employing a "trap" column in front of the sample injector while an ACE C18 and an ACE C18-PFP column were compared for the separation of OPFRs. Nineteen OPFR related compounds were evaluated and rapid signal drops were observed for seven of them including TOTP, TMTP, TPTP, TEHP, T35DMPP, T2iPPP and EHDP, due to their low water solubility. The other twelve compounds, TMP, TEP, TPrP, TiPP, TBP, TCEP, TCPP, TDCPP, TPP, TBEP, BDCP and BEHP, were included for the measurement of OPFRs in drinking water, surface water, ground water and wastewater effluent samples. The instrumental detection limits of these twelve OPFRs at signal-to-noise ≥3 were in the 1.5-30 ng/L range. The method was applied for the determination of OPFRs in surface water and wastewater samples in Ontario, Canada, and BEHP, TBEP, TBP, TCEP, TCPP, TDCPP, and TEP were commonly detected. Crown Copyright © 2017. Published by Elsevier Ltd. All rights reserved.

  5. Lessons Learned from 50+ Years of NSF-Funded Geoscience Teacher Education Initiatives at Michigan Technological University

    Science.gov (United States)

    Klawiter, M.; Klawiter, F.

    2011-12-01

    Michigan Technological University has a long and successful tradition of coupling its spectacular geological setting with a dedicated faculty and staff in efforts to improve geoscience education. Beginning with a National Science Foundation Summer Institute in 1960 and culminating in MiTEP (Michigan Teacher Excellence Program, a NSF-funded Math-Science Partnership) now in midcourse, the presenter will focus on many facets of planning, implementation, and evaluation of several successful MTU Geoscience Education programs funded by NSF. Featuring personal accounts and reminiscences of involvement (beginning in 1960) as an attendee, teacher participant, evaluator, pedagogy consultant, and finally as a graduate student contributing to the planning of NSF-funded professional development activities at Michigan Technological University, the presenter will discuss how a consideration of prior program designs has led to a synthesis of successful strategies employed in MiTEP, including: -Addressing teachers' needs based upon pre-assessments in the planning and implementation of high-quality professional development activities -The employment of extensive and varied field-based learning experiences in expanding teachers' content knowledge -The importance of pedagogy in stimulating improvement in course content -Place-based design -Sustainability of lessons learned through sharing methods (such as lesson study, professional learning communities, and participation in conferences conducted by professional organizations) -Incorporation of resources and initiatives from state and federal agencies and organizations into the design and implementation plan (e.g. ESLP Big Ideas, state and federal academic standards, EarthComm) -Evaluation of program effectiveness and implementation of corrections and/or enhancements based upon critical evaluative feedback -Communication of lessons learned

  6. Integrated resource planning in the power sector and economy-wide changes in environmental emissions

    International Nuclear Information System (INIS)

    Shrestha, Ram M.; Marpaung, Charles O.P.

    2006-01-01

    This paper analyzes the roles of key factors (i.e., changes in structure, fuel mix and final demand) on total economy-wide changes in CO 2 , SO 2 and NO x emissions when power sector development follows the integrated resource planning (IRP) approach instead of traditional supply-based electricity planning (TEP). It also considers the rebound effect (RE) of energy efficiency improvements in the demand side and analyzes the sensitivity of the results to variations in the values of the RE. A framework is developed to decompose the total economy-wide change in the emission of a pollutant into four major components, i.e., structural change-, fuel mix- , final demand- and joint-effects. The final demand effect is further decomposed into three categories, i.e., construction of power plants, electricity final demand and final demand related to electricity using equipment. The factor decomposition framework is then applied in the case of the power sector in Indonesia. A key finding in the case of Indonesia is that in the absence of the RE, there would be total economy-wide reductions in CO 2 , SO 2 and NO x emissions of 431, 1.6 and 1.3 million tons respectively during the planning horizon of 2006-2025 under IRP as compared to that under TEP. The decomposition analysis shows that the final demand effect would account for 38% of the total CO 2 emission reduction followed by the structural change effect (35.1%) and fuel mix effect (27.6%) while the joint effect is negligible. The study also shows that economy-wide CO 2 emission reduction due to IRP considering the RE of 45% would be 241 million tons as compared to 333 million tons when the RE is 25%. (Author)

  7. Integrated resource planning in the power sector and economy-wide changes in environmental emissions

    International Nuclear Information System (INIS)

    Shrestha, Ram M.; Marpaung, Charles O.P.

    2006-01-01

    This paper analyzes the roles of key factors (i.e., changes in structure, fuel mix and final demand) on total economy-wide changes in CO 2 , SO 2 and NO x emissions when power sector development follows the integrated resource planning (IRP) approach instead of traditional supply-based electricity planning (TEP). It also considers the rebound effect (RE) of energy efficiency improvements in the demand side and analyzes the sensitivity of the results to variations in the values of the RE. A framework is developed to decompose the total economy-wide change in the emission of a pollutant into four major components, i.e., structural change-, fuel mix- , final demand- and joint-effects. The final demand effect is further decomposed into three categories, i.e., construction of power plants, electricity final demand and final demand related to electricity using equipments. The factor decomposition framework is then applied in the case of the power sector in Indonesia. A key finding in the case of Indonesia is that in the absence of the RE, there would be total economy-wide reductions in CO 2 , SO 2 and NO x emissions of 431, 1.6 and 1.3 million tons respectively during the planning horizon of 2006-2025 under IRP as compared to that under TEP. The decomposition analysis shows that the final demand effect would account for 38% of the total CO 2 emission reduction followed by the structural change effect (35.1%) and fuel mix effect (27.6%) while the joint effect is negligible. The study also shows that economy-wide CO 2 emission reduction due to IRP considering the RE of 45% would be 241 million tons as compared to 333 million tons when the RE is 25%

  8. Mesopelagic N2 Fixation Related to Organic Matter Composition in the Solomon and Bismarck Seas (Southwest Pacific.

    Directory of Open Access Journals (Sweden)

    Mar Benavides

    Full Text Available Dinitrogen (N2 fixation was investigated together with organic matter composition in the mesopelagic zone of the Bismarck (Transect 1 and Solomon (Transect 2 Seas (Southwest Pacific. Transparent exopolymer particles (TEP and the presence of compounds sharing molecular formulae with saturated fatty acids and sugars, as well as dissolved organic matter (DOM compounds containing nitrogen (N and phosphorus (P were higher on Transect 1 than on Transect 2, while oxygen concentrations showed an opposite pattern. N2 fixation rates (up to ~1 nmol N L-1 d-1 were higher in Transect 1 than in Transect 2, and correlated positively with TEP, suggesting a dependence of diazotroph activity on organic matter. The scores of the multivariate ordination of DOM molecular formulae and their relative abundance correlated negatively with bacterial abundances and positively with N2 fixation rates, suggesting an active bacterial exploitation of DOM and its use to sustain diazotrophic activity. Sequences of the nifH gene clustered with Alpha-, Beta-, Gamma- and Deltaproteobacteria, and included representatives from Clusters I, III and IV. A third of the clone library included sequences close to the potentially anaerobic Cluster III, suggesting that N2 fixation was partially supported by presumably particle-attached diazotrophs. Quantitative polymerase chain reaction (qPCR primer-probe sets were designed for three phylotypes and showed low abundances, with a phylotype within Cluster III at up to 103 nifH gene copies L-1. These results provide new insights into the ecology of non-cyanobacterial diazotrophs and suggest that organic matter sustains their activity in the mesopelagic ocean.

  9. Premenstrual syndrome and fibromyalgia: the frequency of the coexistence and their effects on quality of life.

    Science.gov (United States)

    Soyupek, Feray; Aydogan, Cigdem; Guney, Mehmet; Kose, Seyit Ali

    2017-07-01

    We aimed to investigate the association between Premenstrual syndrome (PMS) and fibromyalgia syndrome (FMS), to assess common symptoms and quality of life (QOL) of them. Patients with PMS formed the PMS group and age-matched healthy normal controls were included in the control group. The diagnosis of the FMS and PMS were based on new American College of Rheumatology FMS criteria and DSM-IV PMS criteria. FMS-related symptoms assessed by visual analog scale and number of tender points (TePs) were analyzed. QOL, PMS severity and FMS severity were assessed with SF-36, fibromyalgia impact questionnaire (FIQ) and premenstrual assessment form (PAF), respectively. Patients with PMS were divided into two subgroups according to coexistence of FMS or not. The frequency of FMS in PMS and control group were 20 and 0%, respectively (p = 0.002). FMS-related symptoms, number of TePs in the PMS group were higher than those in the control group. The mean mental component summary (MCS) score of SF-36 was low in the PMS group. The mean PAF score in PMS with FMS subgroup was higher than those in without FMS subgroup. The mean physical component summary of SF-36 was low in the PMS patient with FMS. There was correlation between PAF score and FIQ score (r = 0.476, p < 0.001). FMS was common among the patients with PMS and frequently seen in the PMS patients having severe premenstrual complaints. Mental QOL was distressed in the patients with PMS but while FMS accompanied to PMS, the physical QOL was decreased.

  10. An in vitro biotic ligand model (BLM) for silver binding to cultured gill epithelia of freshwater rainbow trout (Oncorhynchus mykiss)

    International Nuclear Information System (INIS)

    Zhou Bingsheng; Nichols, Joel; Playle, Richard C.; Wood, Chris M.

    2005-01-01

    'Reconstructed' gill epithelia on filter supports were grown in primary culture from dispersed gill cells of freshwater rainbow trout (Oncorhynchus mykiss). This preparation contains both pavement cells and chloride cells, and after 7-9 days in culture, permits exposure of the apical surface to true freshwater while maintaining blood-like culture media on the basolateral surface, and exhibits a stable transepithelial resistance (TER) and transepithelial potential (TEP) under these conditions. These epithelia were used to develop a possible in vitro version of the biotic ligand model (BLM) for silver; the in vivo BLM uses short-term gill binding of the metal to predict acute silver toxicity as a function of freshwater chemistry. Radio-labeled silver ( 110m Ag as AgNO 3 ) was placed on the apical side (freshwater), and the appearance of 110m Ag in the epithelia (binding) and in the basolateral media (flux) over 3 h were monitored. Silver binding (greater than the approximate range 0-100 μg l -1 ) and silver flux were concentration-dependent with a 50% saturation point (apparent K d ) value of about 10 μg l -1 or 10 -7 M, very close to the 96-h LC50 in vivo in the same water chemistry. There were no adverse effects of silver on TER, TEP, or Na + , K + -ATPase activity, though the latter declined over longer exposures, as in vivo. Silver flux over 3 h was small ( + and dissolved organic carbon (humic acid) concentrations, increased by elevations in freshwater Cl - and reductions in pH, and insensitive to elevations in Ca 2+ . With the exception of the pH response, these effects were qualitatively and quantitatively similar to in vivo BLM responses. The results suggest that an in vitro BLM approach may provide a simple and cost-effective way for evaluating the protective effects of site-specific waters

  11. Distribution of calcifying and silicifying phytoplankton in relation to environmental and biogeochemical parameters during the late stages of the 2005 North East Atlantic Spring Bloom

    Directory of Open Access Journals (Sweden)

    K. Leblanc

    2009-10-01

    Full Text Available The late stage of the North East Atlantic (NEA spring bloom was investigated during June 2005 along a transect section from 45 to 66° N between 15 and 20° W in order to characterize the contribution of siliceous and calcareous phytoplankton groups and describe their distribution in relation to environmental factors. We measured several biogeochemical parameters such as nutrients, surface trace metals, algal pigments, biogenic silica (BSi, particulate inorganic carbon (PIC or calcium carbonate, particulate organic carbon, nitrogen and phosphorus (POC, PON and POP, respectively, as well as transparent exopolymer particles (TEP. Results were compared with other studies undertaken in this area since the JGOFS NABE program. Characteristics of the spring bloom generally agreed well with the accepted scenario for the development of the autotrophic community. The NEA seasonal diatom bloom was in the late stages when we sampled the area and diatoms were constrained to the northern part of our transect, over the Icelandic Basin (IB and Icelandic Shelf (IS. Coccolithophores dominated the phytoplankton community, with a large distribution over the Rockall-Hatton Plateau (RHP and IB. The Porcupine Abyssal Plain (PAP region at the southern end of our transect was the region with the lowest biomass, as demonstrated by very low Chla concentrations and a community dominated by picophytoplankton. Early depletion of dissolved silicic acid (DSi and increased stratification of the surface layer most likely triggered the end of the diatom bloom, leading to coccolithophore dominance. The chronic Si deficiency observed in the NEA could be linked to moderate Fe limitation, which increases the efficiency of the Si pump. TEP closely mirrored the distribution of both biogenic silica at depth and prymnesiophytes in the surface layer suggesting the sedimentation of the diatom bloom in the form of aggregates, but the relative contribution of diatoms and

  12. Tromboembolismo pulmonar e asma de difícil controlo

    Directory of Open Access Journals (Sweden)

    Catarina Teles Martins

    2007-11-01

    Full Text Available Resumo: O controlo da asma é um factor crucial na abordagem do doente: a mais recente actualização do GINA considera que uma “asma difícil de tratar” é uma asma para investigar. O não cumprimento da terapêutica, a DPOC concomitante, o tabagismo, a rinossinusite, o refluxo gastroesofágico e a obesidade são considerados os principais motivadores da asma difícil de controlar.O presente trabalho teve por objectivo avaliar o papel do tromboembolismo pulmonar (TEP na asma grave de difícil controlo.Foram revistos os processos clínicos de doentes asmáticos da consulta de Alergologia Respiratória do nosso Serviço, entre 2004 e 2006, com asma “persistente grave” de acordo com o GINA 2005. Foram seleccionados os que, apesar de terapêutica optimizada, apresentavam asma “não controlada” (GINA 2006 e analisadas as suas causas. Dos 254 doentes estudados, 28 (11% preenchiam os critérios de “asma persistente grave” (idade média 44±18 anos; 86% sexo feminino; destes, 57% (n=16 tinham doença “não controlada” – 35% (n=6 por má adesão à terapêutica; 29% (n=5 por TEP (confirmado gamagra-ficamente; 12% (n=2 por rinossinusite grave; 6% (n=1 por síndroma hipereosinofílica; 6% (n=1 por contacto mantido com alérgenos e 6% (n=1 em estudo.Os doentes com TEP (idade média 56±9 anos; 80% sexo feminino; 80% raça branca tiveram o diagnóstico de asma na idade adulta (média 37 anos, tendo decorrido cerca de 18 anos até ao diagnóstico de TEP. A análise dos factores predisponentes para TEP revelou: insuficiência venosa periférica (40%, HTA (40% e deficiência de proteína C e S funcionais (20%.Todos os doentes efectuaram terapêutica anticoagulante (80% ainda mantém, referindo-se que, após o início da anticoagulação, 40% dos doentes alcançaram o controlo da doença e 40% t

  13. Pulmonary embolism and difficult-to-treat asthma

    Directory of Open Access Journals (Sweden)

    Catarina Teles Martins

    2007-11-01

    asthma. Resumo: O controlo da asma é um factor crucial na abordagem do doente: a mais recente actualização do GINA considera que uma “asma difícil de tratar” é uma asma para investigar. O não cumprimento da terapêutica, a DPOC concomitante, o tabagismo, a rinossinusite, o refluxo gastroesofágico e a obesidade são considerados os principais motivadores da asma difícil de controlar.O presente trabalho teve por objectivo avaliar o papel do tromboembolismo pulmonar (TEP na asma grave de difícil controlo.Foram revistos os processos clínicos de doentes asmáticos da consulta de Alergologia Respiratória do nosso Serviço, entre 2004 e 2006, com asma “persistente grave” de acordo com o GINA 2005. Foram seleccionados os que, apesar de terapêutica optimizada, apresentavam asma “não controlada” (GINA 2006 e analisadas as suas causas. Dos 254 doentes estudados, 28 (11% preenchiam os critérios de “asma persistente grave” (idade média 44 ± 18 anos; 86% sexo feminino; destes, 57% (n = 16 tinham doença “não controlada” – 35% (n = 6 por má adesão à terapêutica; 29% (n = 5 por TEP (confirmado gamagraficamente; 12% (n = 2 por rinossinusite grave; 6% (n = 1 por síndroma hipereosinofílica; 6% (n = 1 por contacto mantido com alérgenos e 6% (n = 1 em estudo.Os doentes com TEP (idade média 56 ± 9 anos; 80% sexo feminino; 80% raça branca tiveram o diagnóstico de asma na idade adulta (média 37 anos, tendo decorrido cerca de 18 anos até ao diagnóstico de TEP. A análise dos factores predisponentes para TEP revelou: insuficiência venosa periférica (40%, HTA (40% e deficiência de proteína C e S funcionais (20%. Todos os doentes efectuaram terapêutica anticoagulante (80% ainda mantém, referindo-se que, após o início da anticoagulação, 40% dos doentes alcan

  14. Transtorno de estresse pós-traumático em uma unidade de saúde de atenção primária Trastorno de estrés postraumático en una unidad de salud de atención primaria Posttraumatic stress disorder in a primary health care service

    Directory of Open Access Journals (Sweden)

    Airton Tetelbom Stein

    2004-08-01

    Full Text Available INTRODUÇÃO: O transtorno de estresse pós-traumático (TEPT caracteriza-se pelo desenvolvimento de sintomas como a re-experienciação do evento traumático (pesadelos, idéias intrusivas, sintomas somáticos relacionados ao momento do trauma, evitação e embotamento (evitar situações, pessoas ou comportamentos que relembrem o trauma e ter dificuldade para lidar com novas situações ou sentimentos e excitabilidade aumentada (insônia, irritação, dificuldade de concentração e um estado permanente de alerta e sobressalto. É importante saber a freqüência do transtorno numa comunidade pobre. OBJETIVO: Identificar a freqüência de TEPT e a presença de sintomas depressivos e alcoolismo em um serviço de atenção primária. METODOLOGIA: O estudo ocorreu na Unidade de Saúde Divina Providência, do Serviço de Saúde Comunitária do Grupo Hospitalar Conceição. Realizou-se uma amostragem aleatória dos pacientes que consultaram no posto. Foram aplicados instrumentos para a identificação de TEPT, sintomas depressivos, alcoolismo e perfil sociodemográfico. RESULTADOS: Dos 54 pacientes entrevistados, 83,3% eram mulheres, e a média da idade foi de 39 anos. Os sintomas depressivos severos foram identificados em 28% dos pacientes; 59% tinham o critério de TEPT e 12,5% apresentavam problemas com álcool. CONCLUSÕES: A amostra do sexo feminino foi predominante e houve uma elevada prevalência de TEPT.INTRODUCCÍON: El trastorno de estrés postraumático (TEP se caracteriza por el desarrollo de síntomas como la retomada de la experimentación del evento traumático (pesadilla, ideas de intrusión, síntomas somáticos relacionados a la ocasión del trauma; evitación y embotamiento (evitar situaciones, personas o comportamientos que recuerden el trauma y tener dificultad para convivir con nuevas situaciones o sentimientos y excitabilidad ampliada (insomnio, irritación, dificultad de concentración y un estado permanente de alerta y

  15. Fibrinogênio sérico pré-operatório como preditor de infarto do miocárdio na cirurgia de revascularização miocárdica Preoperative serum fibrinogen as a predictor of myocardial infarction in the surgical myocardial revascularization

    Directory of Open Access Journals (Sweden)

    Cristiano Pederneiras Jaeger

    2006-09-01

    Full Text Available OBJETIVO: Determinar o valor preditivo do nível sérico de fibrinogênio pré-operatório para a ocorrência de infarto do miocárdio (IM no período perioperatório de cirurgia de revascularização miocárdica (CRM, bem como para outros desfechos de impacto, como acidente vascular encefálico isquêmico (AVEI, tromboembolismo pulmonar (TEP e morte, isoladamente e de maneira composta. MÉTODOS: Estudo de coorte retrospectivo com análise do banco de dados de cirurgia cardíaca do Hospital São Lucas da PUC-RS, com 1.471 pacientes consecutivos que realizaram CRM com circulação extracorpórea entre janeiro de 1998 e dezembro de 2002. RESULTADOS: IM perioperatório ocorreu em 14% dos pacientes da amostra. Não foi observada associação entre o fibrinogênio pré-operatório e IM perioperatório (410,60 ± 148,83 mg/dl para o grupo em estudo x 401,57 ±135,23 mg/dl para o grupo controle - p = 0,381 - RC = 1,000 - IC95%: 0,998-1,002 - p = 0,652, o desfecho combinado de IM, AVEI, TEP e morte (411,40 ± 153,52 mg/dl para o grupo com o desfecho x 400,31 ± 131,98 mg/dl para o grupo sem o desfecho - p = 0,232 e nem com cada um destes isoladamente. CONCLUSÃO: Nesta amostra, o nível sérico de fibrinogênio pré-operatório não apresentou associação com a ocorrência de IM perioperatório nas CRM, nem mesmo com outros desfechos de impacto, incluindo AVEI, TEP e morte, isoladamente ou em conjunto.OBJECTIVE: Determine the predictive level of preoperative serum fibrinogen level for the occurrence of MI in perioperative surgical myocardial revascularization (SMR, as well as for other impacting outcomes, such as stroke, pulmonary thromboembolism (PTE, and death, separately or in combination. METHODS: A retrospective cohort study based on the heart surgery database analysis from São Lucas Hospital, at Rio Grande do Sul Catholic University with 1,471 consecutive patients submitted to extracorporeal SMR between January, 1998 and December, 2002. RESULTS

  16. Variáveis capnográficas pré e pós-tromboendarterectomias pulmonares Pre and post-pulmonary thromboendarterectomies campnographic variables

    Directory of Open Access Journals (Sweden)

    Marcos Mello Moreira

    2007-12-01

    Full Text Available Este relato de dois casos com os resultados da fração tardia de espaço morto (fDlate, fração do espaço morto alveolar end-tidal (AVDSf, gradiente artério-alveolar de CO2 [P(a-etCO2] e slope da fase 3 do espirograma, submetidos à tromboendarterectomia pulmonar por tromboembolismo pulmonar (TEP. O TEP foi diagnosticado pela cintilografia pulmonar, tomografia helicoidal computadorizada e por arteriografia pulmonar. O cálculo da fDlate, AVDSf e P(a-etCO2 baseou-se na capnografia volumétrica associada à gasometria arterial. A fDlate préoperatória do primeiro paciente foi de 0,16 (cutoff de 0,12 e a AVDSf = 0,30 (cutoff de 0,15. Já a fDlate do segundo paciente resultou falso-negativa (0,01, embora a AVDSf resultasse positiva (0,28. A fDlate pós-operatória do primeiro paciente foi de -0,04 e a AVDSf de 0,16; a fDlate do segundo paciente foi de 0,07 e a AVDSf = 0,28. A associação destas variáveis com os exames por imagem reforça a importância deste método como ferramenta diagnóstica não-invasiva no diagnóstico de TEP.In these case report, the results of late dead space fraction (fDlate, end-tidal alveolar dead space fraction (AVDSf, arterial-alveolar gradient CO2 [P(a-etCO2], and slope phase 3 of spirogram of two patients who underwent thromboendarterectomy for pulmonary embolism (PE are shown. PE was diagnosed by pulmonary scintigraphy, helical tomography, and pulmonary angiography. The calculation of fDlate, AVDSf and P(a-etCO2 was based on volumetric capnography associated with arterial blood gas analysis. The pre-operative fDlate of the first patient was 0.16 (cutoff 0.12 and AVDSf was 0.30 (cutoff 0.15. However, the fDlate of the second patient was false-negative (0.01 but, the AVDSf was positive (0.28. Postoperative fDlate of the first patient was -0.04 and AVDSf was 0.16; for the second patient, the values were 0.07 and 0.28, respectively. The association of these capnographic variables with image exams reinforces the

  17. The contribution of the Geohazards Exploitation Platform for the GEO Supersites community

    Science.gov (United States)

    Manunta, Michele; Caumont, Hervé; Mora, Oscar; Casu, Francesco; Zinno, Ivana; De Luca, Claudio; Pepe, Susi; Pepe, Antonio; Brito, Fabrice; Romero, Laia; Stumpf, Andre; Malet, Jean-Philippe; Brcic, Ramon; Rodriguez Gonzalez, Fernando; Musacchio, Massimo; Buongiorno, Fabrizia; Briole, Pierre

    2016-04-01

    The European Space Agency (ESA) initiative for the creation of an ecosystem of Thematic Exploitation Platforms (TEP) focuses on the capitalization of Ground Segment capabilities and ICT technologies to maximize the exploitation of EO data from past and future missions. A TEP refers to a computing platform that complies to a set of exploitation scenarios involving scientific users, data providers and ICT providers, aggregated around an Earth Science thematic area. The Exploitation Platforms are targeted to cover different capacities and they define, implement and validate a platform for effective data exploitation of EO data sources in a given thematic area. In this framework, the Geohazards Thematic Exploitation Platform or Geohazards TEP (GEP) aims at providing on-demand processing services for specific user needs as well as systematic processing services to address the need of the geohazards community for common information layers and, finally, to integrate newly developed processors for scientists and other expert users. The GEP has now on-boarded over 40 European early adopters and will transition during 2016 to pre-operations by developing six new Pilot applications that will significantly augment the Platform's capabilities for systematic production and community building. Each project on the Platform is concerned with either integrating an application, running on demand processing using an application available in the platform or systematically generating a new product collection. The platform will also expand its user base in 2016, to gradually reach a total of about 65 individual users. Under a Consortium lead by Terradue Srl, six new pilot projects have been taken on board: photogrammetric processing using optical EO data with University of Strasbourg (FR), optical based processing method for volcanic hazard monitoring with INGV (IT), systematic generation of deformation time-series with Sentinel-1 data with CNR IREA (IT), systematic processing of

  18. Cortisol sérico e glicemia em cadelas tratadas com tramadol e submetidas à ovário-histerectomia

    Directory of Open Access Journals (Sweden)

    Caldeira Fátima Maria Caetano

    2006-01-01

    Full Text Available O tramadol é um analgésico opióide usado em medicina veterinária, embora existam poucos estudos sobre este fármaco. O objetivo deste trabalho foi avaliar o efeito analgésico promovido pela administração do tramadol, mensurando o cortisol sérico e a glicemia de cadelas. Para isso, foram utilizadas 15 fêmeas, submetidas a ovário-histerectomia sob anestesia geral com isofluorano. Os animais foram divididos em três grupos. Grupo 1 (Tep receberam tramadol pela via epidural (1,0mg kg-1 diluído em água bidestilada ao volume final de 3,0mL e, após 15 minutos, 3,0mL de água bidestilada pela via intravenosa. No grupo 2 (Tiv, foi administrado 3,0mL de água bidestilada pela via epidural e, após 15 minutos, tramadol pela via intravenosa (1,0mg kg-1 diluído em água bidestilada ao volume final de 3,0mL. No grupo 3 (CT, os animais receberam 3,0mL de água bidestilada pela via epidural e, após 15 minutos, 3,0mL de água bidestilada pela via intravenosa. A eficácia de cada regime analgésico foi avaliada durante 12 horas após a administração da injeção epidural. Não houve diferença significativa entre os grupos experimentais para as variáveis estudadas (P>0,05. Foram observadas diferenças significativas dentro de cada tratamento. No grupo Tep houve aumento do cortisol sérico aos 25 minutos do trans-operatório (M3, em relação ao valor obtido imediatamente após a indução anestésica (M2 (P>0,05. Nos tratamentos Tiv e CT, verificou-se elevação das variáveis, duas (M4 e quatro (M5 horas da injeção epidural (P<0,05, quando comparadas ao pré-tratamento (M1. Nesses períodos, as variáveis estudadas no tratamento Tep foram estatisticamente semelhantes ao pré-tratamento (M1. Com base nos resultados, conclui-se que: 1 a metodologia empregada foi sensível para determinar os momentos de maior estresse cirúrgico, dentre os estudados e 2 o tramadol por via epidural produz analgesia mais duradoura quando comparado à administra

  19. Yb-based heavy fermion compounds and field tuned quantum chemistry

    Energy Technology Data Exchange (ETDEWEB)

    Mun, Eundeok [Iowa State Univ., Ames, IA (United States)

    2010-01-01

    The motivation of this dissertation was to advance the study of Yb-based heavy fermion (HF) compounds especially ones related to quantum phase transitions. One of the topics of this work was the investigation of the interaction between the Kondo and crystalline electric field (CEF) energy scales in Yb-based HF systems by means of thermoelectric power (TEP) measurements. In these systems, the Kondo interaction and CEF excitations generally give rise to large anomalies such as maxima in ρ(T) and as minima in S(T). The TEP data were use to determine the evolution of Kondo and CEF energy scales upon varying transition metals for YbT2Zn20 (T = Fe, Ru, Os, Ir, Rh, and Co) compounds and applying magnetic fields for YbAgGe and YbPtBi. For YbT2Zn20 and YbPtBi, the Kondo and CEF energy scales could not be well separated in S(T), presumably because of small CEF level splittings. A similar effect was observed for the magnetic contribution to the resistivity. For YbAgGe, S(T) has been successfully applied to determine the Kondo and CEF energy scales due to the clear separation between the ground state and thermally excited CEF states. The Kondo temperature, TK, inferred from the local maximum in S(T), remains finite as magnetic field increases up to 140 kOe. In this dissertation we have examined the heavy quasi-particle behavior, found near the field tuned AFM quantum critical point (QCP), with YbAgGe and YbPtBi. Although the observed nFL behaviors in the vicinity of the QCP are different between YbAgGe and YbPtBi, the constructed H-T phase diagram including the two crossovers are similar. For both YbAgGe and YbPtBi, the details of the quantum criticality turn out to be complicated. We expect that YbPtBi will provide an additional example of field tuned quantum criticality, but clearly there are further experimental investigations left and more ideas needed to understand the basic physics of field-induced quantum

  20. Pulmonary thromboembolism in AIDS patient with chronic venous insufficiency, pulmonary tuberculosis and breast cancer: a case report and pathophysiology review Tromboembolismo pulmonar em uma paciente com AIDS com insuficiência venosa profunda, tuberculose pulmonar e câncer de mama: relato de um caso e revisão da fisiopatologia

    Directory of Open Access Journals (Sweden)

    Juan José Cortez-Escalante

    2006-04-01

    ções tromboembólicas incluindo o TEP nos pacientes com AIDS. O TEP nesta paciente foi um desafio diagnóstico, considerando todas as outras doenças graves que apresentou simultaneamente.

  1. In-service and pre-service teacher education in IBSE: The ESTABLISH approach

    Science.gov (United States)

    Ješková, Zuzana; Kireš, Marián; McLoughlin, Eilish; Finlayson, Odilla; Ottander, Christina; Ekborg, Margareta

    2016-05-01

    One of the main goals of the ESTABLISH 7fp project (available on line at http://www.establish-fp7.eu/) was the development and implementation of the professional development teacher education programmes (TEP) to support teachers in adopting inquiry-based strategies in their teaching. Within the project there was a model for in-service and pre-service teacher training in IBSE designed and implemented across 12 participating countries. The programme is based on 4 core elements and 4 additional elements that are built around the IBSE teaching units developed within the project. As accepted by ESTABLISH partners, all teacher training programmes include the minimum of the four elements, i.e. introduction to IBSE, industrial content knowledge, teacher as implementer and teacher as developer of IBSE teaching materials. There are also four additional elements designed in detail, i.e. ICT for IBSE, argumentation in the classroom, research and design projects for students, assessment of IBSE. These can be added to the programme optionally with regard to the level of teachers' IBSE skills and current situation in education and teachers' professional development within the country. This ESTABLISH model of TEP was followed in participating countries in order to change teachers' attitudes from traditional ways of teaching towards adopting inquiry strategies and their successful implementation in the classroom. Within the face-to-face workshops teachers experienced and developed their inquiry based teaching strategies using specifically developed materials. In addition, the e-platform has been developed to provide on-line support. This platform provides educators and teachers with all the necessary materials for the training and IBSE teaching units and other teaching materials for teachers' ongoing help. The teacher training programme was successfully implemented in Slovakia. There were two runs of teacher training workshops on IBSE already carried out. Moreover, the additional

  2. Avaliação funcional da nocicepção do joelho de ratos tratada com laser de baixa potência e natação

    Directory of Open Access Journals (Sweden)

    Gladson Ricardo Flor Bertolini

    2011-02-01

    Full Text Available O objetivo deste estudo foi avaliar e comparar os efeitos do laser de baixa potência e da natação forçada em modelo de nocicepção articular, de ratos Wistar, avaliando a dor de forma funcional, pelo tempo de elevação da pata (TEP durante marcha em cilindro metálico. Foram utilizados 32 ratos Wistar, divididos em quatro grupos: GC - animais submetidos à indução de nocicepção no joelho direito e não tratados; GL - nocicepção e tratados com laser de baixa potência 670nm, 8J/cm²; GN - nocicepção e natação por 10 minutos em água a 30-32ºC; GNL - nocicepção e tratados com natação e laser. Para realizar a nocicepção foi injetado, no espaço tibiofemoral medial direito, 50µL de formalina 5%. A avaliação funcional da dor foi realizada com o teste de incapacidade funcional, que avalia o tempo de pata no ar (TEP da marcha durante um minuto sobre um cilindro metálico, as avaliações ocorreram antes da indução da nocicepção (AV1, após 15 (AV2 e 30 minutos (AV3 da mesma, sendo que após a AV2, ocorreram os protocolos de tratamento. Os resultados mostraram que o grupo laser foi o único a apresentar restauração dos valores na AV3, comparando com AV1. GN foi o único a não apresentar redução ao comparar AV3 com AV2. Conclui-se que, pela avaliação funcional, o laser de baixa potência apresentou efeitos analgésicos, enquanto a natação produziu aumento do quadro de dor, o qual foi parcialmente revertido com o uso do laser associado

  3. Improving the Gap between Model Predictions and Observations of Formaldehyde over the Remote Marine Regions

    Science.gov (United States)

    Trueblood, J.; Meskhidze, N.

    2013-05-01

    Formaldehyde (HCHO) is a ubiquitous oxidation product that exists in polluted rural and urban areas, as well as remote background sites where it is an important photochemical intermediate. HCHO levels of up to six times above what is typically predicted by photochemical models have been reported over the Marine Boundary Layer (MBL). As proposed mechanisms for HCHO production remain to be insufficient to explain such large discrepancies between model predictions and measured values, the role of marine regions in the creation of HCHO continues to be one of the largest sources of uncertainty in current global chemistry-transport models. Here we examine the viability of a proposed mechanism for the photochemical production of formaldehyde involving aerosols enriched with biologically produced organic matter. In this study, the phytoplankton Emiliania Huxleyi was incubated in autoclaved seawater contained within a 9 liter Pyrex glass bottle. Quantitative analysis of the enrichment of transparent exopolymer particles (TEP) and other biologically produced organic matter (dissolved and particulate) in the surface microlayer was carried out by employing Alldredge's alcian blue staining technique. To produce organic aerosols, enriched seawater was bubbled with hydrocarbon free air using a sintered glass filter placed 5 cm below the surface. Utilizing a mixed flow reaction scheme, produced aerosols were then pushed through stainless steel flow tubes into a separate 9-liter Pyrex glass container acting as a residence chamber. The container was surrounded with six Ushio 9W Midrange UVB lights to allow for the irradiation of aerosols at 306 nm. A flow rate of approximately 0.1 l/min allowed for an average aerosol residence time of 90 minutes inside the residence chamber. All air from the chamber was then passed through a 5" long Pyrex desorber tube packed with 60/80 Tenax that had been soaked in the derivatizing agent pentafluorophenyl hydrazine (PFPH). Subsequent thermal

  4. The distribution and accumulation of phosphate flame retardants (PFRs) in water environment.

    Science.gov (United States)

    Zhang, Ying; Zheng, Xiaobo; Wei, Lifei; Sun, Runxia; Guo, Huiying; Liu, Xinyu; Liu, Shengyu; Li, Yi; Mai, Bixian

    2018-02-21

    Phosphate flame retardants (PFRs) were measured in surface water (n=11), suspended particle matter (SPM, n=11), sediment (n=11), and fish samples (n=26) from the Pearl River Delta located in South China. Triethyl phosphate (TEP), tri(2-chloroethyl) phosphate (TCEP), tris(chloroisopropyl) phosphate (TCIPP), tri-n-butyl phosphate (TNBP), triphenyl phosphate (TPHP), and tricresyl phosphate (TMPP) were detected in more than half of surface water, SPM, and sediment samples. The median ΣPFR levels were 837ng/L, 54.6ng/g dry weight (dw), and 37.1ng/g dw in surface water, SPM, and sediment samples, respectively. No significant correlations were found between the concentrations of most PFRs and organic carbon contents in SPM and sediment (p>0.05). In surface water samples, tris(2-butoxyethyl) phosphate (TBOEP, 27% of ΣPFRs) and TEP (23% of ΣPFRs) were the predominant chemicals, while TNBP (38% of ΣPFRs) and TCEP (32% of ΣPFRs) dominated in ΣPFRs in SPM samples, and TCEP (48% of ΣPFRs) and TCIPP (25% of ΣPFRs) dominated in ΣPFRs in sediment samples. The proportions of phenyl-PFRs and chlorinated-PFRs in ΣPFRs increased from surface water to SPM and sediment. The distribution ratios of PFRs between water and organic carbon in SPM (or observed K OC ) were generally 2-3 orders of magnitude higher than the predicted K OC . TNBP (nd-2.42ng/g wet weight (ww)), TCEP (nd-4.96ng/g ww), and TCIPP (nd-2.42ng/g ww) were detected in 27%, 35%, and 23% of all fish samples, respectively. The log bioaccumulation factors (BAFs) ranged 2.56-2.78, 2.15-3.11, and 2.61-3.10 for TNBP, TCEP, and TCIPP, respectively. The biota-sediment accumulation factors (BSAFs) of TNBP, TCEP, and TCIPP were generally lower than 1 except for the BSAF of TCIPP in common carp. The results indicate the species-specific bioaccumulation of PFRs in fish species. Copyright © 2018 Elsevier B.V. All rights reserved.

  5. An Assessment of Subsurface Intake Systems: Planning and Impact on Feed Water Quality for SWRO Facilities

    KAUST Repository

    Dehwah, Abdullah

    2017-12-01

    Subsurface intake systems are known to improve the feed water quality for SWRO plants. However, a little is known about the feasibility of implementation in coastal settings, the degree of water quality improvements provided by these systems, and the internal mechanisms of potential fouling compounds removal within subsurface intake systems. A new method was developed to assess the feasibility of using different subsurface intake systems in coastal areas and was applied to Red Sea coastline of Saudi Arabia. The methodology demonstrated that five specific coastal environments could support well intake systems use for small-capacity SWRO plants, whereas large-capacity SWRO facilities could use seabed gallery intake systems. It was also found that seabed intake system could run with no operational constraints based on the high evaporation rates and associated diurnal salinity changes along the coast line. Performance of well intake systems in several SWRO facilities along the Red Sea coast showed that the concentrations of organic compounds were reduced in the feed water, similar or better than traditional pretreatment methodologies. Nearly all algae, up to 99% of bacteria, between 84 and 100% of the biopolymer fraction of NOM, and a high percentage of TEP were removed during transport through the aquifer. These organics cause membrane biofouling and using well intakes showed a 50-75% lower need to clean the SWRO membranes compared to conventional open-ocean intakes. An assessment of the effectiveness of seabed gallery intake systems was conducted through a long-term bench-scale column experiment. The simulation of the active layer (upper 1 m) showed that it is highly effective at producing feed water quality improvements and acts totally different compared to slow sand filtration systems treating freshwater. No development of a “schmutzdecke” layer occurred and treatment was not limited to the top 10 cm, but throughout the full column thickness. Algae and

  6. Sense of Place and the National Parks, Strategies for Communicating the Interconnected Nature of Earth Science

    Science.gov (United States)

    Vye, E. C.; Rose, W. I.; Huntoon, J. E.; Nash, B. L.

    2010-12-01

    Using sense of place can help scientists improve their communication of complex concepts related to the connectivity of the environment, geological processes, and human societies. National parks afford excellent examples of places that contain intellectual and emotional stimuli for diverse individuals - in other words, they foster a sense of place. Parks contain spectacular examples of how the processes that shape the earth influence ecosystem and societal development. Parks can therefore be used as outdoor classrooms to engage people in place-based Earth Science education. Incorporating place-based teaching methods can promote learning about Earth’s processes that ensures that a wider audience can be reached than by traditional instructional methods. Specific examples of using national parks on the Colorado Plateau, in the Rocky Mountains and the Keweenaw Peninsula for K-12 teacher training have resulted in a deepening of Earth Science content-area knowledge. The National Parks “Views of the National Park (Views)” multimedia education program can subsequently be used to promote engagement of students in the teachers’ classrooms. Teachers who wish to continue their education as interns in the parks are served by programs such as Geoscientists-in-the-Parks, Volunteers-in-Parks, and Teacher-Ranger-Teacher programs. The Michigan Teaching Excellence Program (MiTEP), multi-year teacher leadership and professional development program is working with middle-grade science teachers from selected urban districts and using the parks of the Midwest as natural classrooms. MiTEP has partnered with the NPS to develop internship opportunities for teachers in the parks. These internships will result in educational materials that can be hosted by “Views”. The goal of the internships are to improve teachers’ understanding of the natural environment and the processes that it reflects, and to assist park personnel in producing materials that are standards-based, age

  7. Rationale, design, and protocol for the prevention of low back pain in the military (POLM trial (NCT00373009

    Directory of Open Access Journals (Sweden)

    Dugan Jessica L

    2007-09-01

    Full Text Available Abstract Background There are few effective strategies reported for the primary prevention of low back pain (LBP. Core stabilization exercises targeting the deep abdominal and trunk musculature and psychosocial education programs addressing patient beliefs and coping styles represent the current best evidence for secondary prevention of low back pain. However, these programs have not been widely tested to determine if they are effective at preventing the primary onset and/or severity of LBP. The purpose of this cluster randomized clinical trial is to determine if a combined core stabilization exercise and education program is effective in preventing the onset and/or severity of LBP. The effect of the combined program will be compared to three other standard programs. Methods/Design Consecutive Soldiers participating in advanced individual training (AIT will be screened for eligibility requirements and consented to study participation, as appropriate. Companies of Soldiers will be randomly assigned to receive the following standard prevention programs; a core stabilization exercise program (CSEP alone, a CSEP with a psychosocial education (PSEP, a traditional exercise (TEP, or a TEP with a PSEP. Proximal outcome measures will be assessed at the conclusion of AIT (a 12 week training period and include imaging of deep lumbar musculature using real-time ultrasound imaging and beliefs about LBP by self-report questionnaire. We are hypothesizing that Soldiers receiving the CSEP will have improved thickness of selected deep lumbar musculature (transversus abdominus, multifidi, and erector spinae muscles. We are also hypothesizing that Soldiers receiving the PSEP will have improved beliefs about the management of LBP. After AIT, Soldiers will be followed monthly to measure the distal outcomes of LBP occurrence and severity. This information will be collected during the subsequent 2 years following completion of AIT using a web-based data entry system

  8. Necrotizing Fasciitis Associated with Pregnancy: a Population-Based Cohort Study.

    Science.gov (United States)

    Oud, Lavi; Watkins, Phillip

    2014-12-01

    Necrotizing fasciitis (NF) is a rare complication in pregnant women. There have been no population-level data reported to date on its epidemiology, clinical features, resource utilization, and outcomes. This was a retrospective, population-based cohort study, using the Texas Inpatient Public Use Data File to identify pregnancy-associated hospitalizations for the years 2001-2010. Hospitalizations with a diagnosis of NF were then identified using the International Classification of Diseases, Ninth Revision, Clinical Modification code 728.86. Denominator data for incidence estimates were derived from the Texas Center for Health Statistics reports of live births, abortions and fetal deaths, and previously reported population-based, age-specific linkage data on miscarriage, and were used to estimate the annual total number of pregnancies (TEP). The incidence of pregnancy-associated NF (PANF), hospitalization type, clinical features, resource utilization and outcomes were examined. There were 4,060,201 pregnancy-associated hospitalizations and 148 PANF hospitalizations during study period. Postpartum hospitalizations accounted for 82.4% of all PANF events, and intensive care unit care was required in 61.5%. The key trends noted between 2001-2002 and 2009-2010 included rising incidence of PANF from 1.1 vs. 3.8 per 100,000 TEP-years (P = 0.0001), chronic comorbidities 0% vs. 31.7% (P = 0.0777), and development of organ failure in 9.1% vs. 31.7% (P = 0.0302). There was no significant change in total hospital charges or hospital length of stay. Three patients (2%) died in the hospital and 55% of survivors had routine home discharge. The present cohort of PANF is the largest reported to date. The incidence of PANF rose nearly 3.5-fold over the past decade, with most events developing following delivery hospitalization. Chronic illness has been increasingly present, along with rising severity of illness. The majority of patients required ICU care. Hospital mortality was

  9. Evolving trends in the epidemiology, resource utilization, and outcomes of pregnancy-associated severe sepsis: a population-based cohort study.

    Science.gov (United States)

    Oud, Lavi; Watkins, Phillip

    2015-06-01

    Infections are a well-known complication of pregnancy. However, pregnancy-associated severe sepsis (PASS) has not been as well-characterized, with limited population-level data reported to date. We performed a population-based study of the evolving patterns of the epidemiology, clinical characteristics, resource utilization, and outcomes of PASS in Texas over the past decade. The Texas Inpatient Public Use Data File was used to identify pregnancy-associated hospitalizations and PASS hospitalizations for the years 2001 - 2010. The Texas Center for Health Statistics reports of live births, abortions and fetal deaths, and a previously reported population-based, age-specific linkage study on miscarriage were used to derive the annual total estimated pregnancies (TEPs). The incidence, demographics, clinical characteristics, resource utilization and outcomes of PASS were examined. Logistic regression modeling was used to explore the predictors of PASS and its associated mortality. There were 4,060,201 pregnancy-associated hospitalizations and 1,007 PASS hospitalizations during study period. The incidence of PASS was increased by 236% over the past decade, rising from 11 to 26 hospitalizations per 100,000 TEPs. The key changes between 2001 - 2002 and 2009 - 2010 within PASS hospitalizations included: admission to ICU 78% vs. 90% (P = 0.002); development of ≥ 3 organ failures 9% vs. 35% (P < 0.0001); and inflation-adjusted median hospital charges (2,010 dollars) $64,034 vs. $89,895 (P = 0.0141). Hospital mortality (11%) remained unchanged during study period. Chronic liver disease (adjusted odds ratio (aOR) 41.4) and congestive heart failure (CHF) (aOR 20.5) were associated with the highest risk of PASS, in addition to black race, poverty, drug abuse, and lack of health insurance. The highest risk of death was among women with HIV infection (aOR 45.5), need for mechanical ventilation (aOR 4.5), drug abuse (aOR 3.0), and lacking health insurance (aOR 2.9). The incidence

  10. Determinação da espessura de filme bioativo SiO2-CaO-P2O5 obtido via sol-gel Evaluation of the thickness of SiO2-CaO-P2O5 bioactive film obtained via sol-gel

    Directory of Open Access Journals (Sweden)

    S. R. Federman

    2009-06-01

    Full Text Available Foi preparado um filme bioativo do sistema SiO2-CaO-P2O5 via sol-gel pela hidrólise e condensação de TEOS, TEP, álcool e nitrato de cálcio em meio ácido. Após a mistura, a solução sintetizada serviu para revestir substrato de aço inoxidável pelo método de imersão utilizando baixa velocidade de emersão. Após o revestimento, o compósito foi tratado termicamente em diferentes temperaturas durante 1 h, com o propósito de avaliar a influência do tratamento térmico especificamente na espessura do filme revestindo o substrato metálico. A influência da variação da temperatura foi acessada através das técnicas de microscopia eletrônica de varredura (MEV e espectroscopia de centelhamento (GDS. Os resultados comprovaram a influência da temperatura na espessura do filme obtido. A reduzida espessura do filme bioativo foi determinada por MEV e GDS.A sol-gel bioactive film of the SiO2-CaO-P2O5 system was prepared, via a sol-gel method, by hydrolysis and condensation of tetraethylortosilicate [TEOS], triethylphosphate [TEP] and hydrated calcium nitrate under acidic conditions. After mixing, the as-obtained solution was used to coat stainless steel substrates by dip-coating in a low withdraw speed. After deposition, the composite was heat treated at different temperatures for 1 h to evaluate the temperature influence on the thickness of the coating over the stainless steel substrate. The development of the coating thickness was accessed through the techniques of scanning electronic microscopy (SEM and glow discharge spectroscopy (GDS. Results indicated the heat treatment effect on the film thickness. Also, the SEM and the GDS techniques were used to determine the thin bioactive coating thickness.

  11. Advanced Therapy Medicinal Products for Rare Diseases: State of Play of Incentives Supporting Development in Europe

    Directory of Open Access Journals (Sweden)

    Andreas M. Farkas

    2017-05-01

    Full Text Available In 2008, the European Union introduced the Advanced Medicines Regulation aiming to improve regulation of advanced therapy medicinal products (ATMPs. We applied the ATMPs classification definitions in this Regulation to understand the link of this emerging group of medicinal products and the use of the Orphan Regulation. A total of 185 products that can be classified as ATMPs based on this Regulation have been submitted for orphan designation. Prior to its introduction in 2008, 4.5% of the products submitted for orphan designation met these criteria. This percentage went up to 15% after 2008. We analyzed several parameters associated with active ATMP ODDs focusing on sponsor type and EU-Member State origin, therapeutic area targeted, and ATMP classification [i.e., somatic cell therapy medicinal product, tissue-engineered product (TEP, or gene therapy medicinal product (GTMP] and the use of regulatory services linked to incentives such as the use of protocol assistance (PA and other Committees [Committee for Advanced Therapies (CAT and the Pediatric Committee]. The aim here was to gain insight on the use of different services. The UK submits the largest number of ATMPs for ODD representing ~30% of the total to date. Few submissions have been received from central and Eastern European Member States as well as some of the larger Member States such as Germany (3.6%. ATMPs ODDs were primarily GTMPs (48.7% and SCTMPs (43.3%. TEPs only represented 8% of all submissions for this medicinal class. This is different from non-ODDs ATMPs where GTMPs make only 20% of ATMPs. A total of 11.7% of ATMP ODDs had received formal CAT classification. A total of 29.8% of all orphan drug (OD ATMPs requested PA. A total of 71.8% did not have an agreed pediatric investigation plan (PIP. Four products (Glybera one PA; Zalmoxis two; Holoclar one; Strimvelis three have received a marketing authorization (MAA and a 10-year market exclusivity. Strimvelis also completed their

  12. Advanced Therapy Medicinal Products for Rare Diseases: State of Play of Incentives Supporting Development in Europe.

    Science.gov (United States)

    Farkas, Andreas M; Mariz, Segundo; Stoyanova-Beninska, Violeta; Celis, Patrick; Vamvakas, Spiros; Larsson, Kristina; Sepodes, Bruno

    2017-01-01

    In 2008, the European Union introduced the Advanced Medicines Regulation aiming to improve regulation of advanced therapy medicinal products (ATMPs). We applied the ATMPs classification definitions in this Regulation to understand the link of this emerging group of medicinal products and the use of the Orphan Regulation. A total of 185 products that can be classified as ATMPs based on this Regulation have been submitted for orphan designation. Prior to its introduction in 2008, 4.5% of the products submitted for orphan designation met these criteria. This percentage went up to 15% after 2008. We analyzed several parameters associated with active ATMP ODDs focusing on sponsor type and EU-Member State origin, therapeutic area targeted, and ATMP classification [i.e., somatic cell therapy medicinal product, tissue-engineered product (TEP), or gene therapy medicinal product (GTMP)] and the use of regulatory services linked to incentives such as the use of protocol assistance (PA) and other Committees [Committee for Advanced Therapies (CAT) and the Pediatric Committee]. The aim here was to gain insight on the use of different services. The UK submits the largest number of ATMPs for ODD representing ~30% of the total to date. Few submissions have been received from central and Eastern European Member States as well as some of the larger Member States such as Germany (3.6%). ATMPs ODDs were primarily GTMPs (48.7%) and SCTMPs (43.3%). TEPs only represented 8% of all submissions for this medicinal class. This is different from non-ODDs ATMPs where GTMPs make only 20% of ATMPs. A total of 11.7% of ATMP ODDs had received formal CAT classification. A total of 29.8% of all orphan drug (OD) ATMPs requested PA. A total of 71.8% did not have an agreed pediatric investigation plan (PIP). Four products (Glybera one PA; Zalmoxis two; Holoclar one; Strimvelis three) have received a marketing authorization (MAA) and a 10-year market exclusivity. Strimvelis also completed their PIP

  13. Risk of discontinuation of Advanced Therapy Medicinal Products clinical trials.

    Science.gov (United States)

    Hanna, Eve; Rémuzat, Cecile; Auquier, Pascal; Toumi, Mondher

    2016-01-01

    Advanced therapy medicinal products (ATMPs) constitute a class of innovative products that encompasses gene therapy, somatic cell therapy, and tissue-engineered products (TEP). There is an increased investment of commercial and non-commercial sponsors in this field and a growing number of ATMPs randomized clinical trials (RCT) and patients enrolled in such trials. RCT generate data to prove the efficacy of a new therapy, but the discontinuation of RCTs wastes scarce resources. Our objective is to identify the number and characteristics of discontinued ATMPs trials in order to evaluate the rate of discontinuation. We searched for ATMPs trials conducted between 1999 to June 2015 using three databases, which are Clinicaltrials.gov, the International Clinical Trials Registry Platform (ICTRP), and the EU Drug Regulating Authorities Clinical Trials (EudraCT). We selected the ATMPs trials after elimination of the duplicates. We identified the disease areas and the sponsors as commercial or non-commercial organizations. We classified ATMPs by type and trial status, that is, ongoing, completed, terminated, discontinued, and prematurely ended. Then, we calculated the rate of discontinuation. Between 1999 and June 2015, 143 withdrawn, terminated, or prematurely ended ATMPs clinical trials were identified. Between 1999 and June 2013, 474 ongoing and completed clinical trials were identified. Therefore, the rate of discontinuation of ATMPs trials is 23.18%, similar to that for non-ATMPs drugs in development. The probability of discontinuation is, respectively, 27.35, 16.28, and 16.34% for cell therapies, gene therapies, and TEP. The highest discontinuation rate is for oncology (43%), followed by cardiology (19.2%). It is almost the same for commercial and non-commercial sponsors; therefore, the discontinuation reason may not be financially driven. No failure risk rate per development phase is available for ATMPs. The discontinuation rate may prove helpful when assessing the

  14. In Vivo Effects of Free Form Astaxanthin Powder on Anti-Oxidation and Lipid Metabolism with High-Cholesterol Diet.

    Directory of Open Access Journals (Sweden)

    Yung-Yi Chen

    Full Text Available Astaxanthin extracted from Pomacea canaliculata eggs was made into free-form astaxanthin powder (FFAP and its effects on lipid metabolism, liver function, antioxidants activities and astaxanthin absorption rate were investigated. 45 hamsters were split into 5 groups and fed with normal diet, high-cholesterol control (0.2% cholesterol, 1.6FFAP (control+1.6% FFAP, 3.2FFAP (control+3.2% FFAP and 8.0FFAP (control+8.0% FFAP, respectively, for 6 weeks. FFAP diets significantly decreased the liver total cholesterol, triglyceride levels and increased liver fatty acids (C20:5n3; C22:6n3 compositions. It decreased plasma alanine aminotransferase and aspartate aminotransferase. In terms of anti-oxidative activities, we found 8.0 FFAP diet significantly decreased plasma and liver malonaldehyde (4.96±1.96 μg TEP eq./mL and 1.56±0.38 μg TEP eq./g liver and liver 8-isoprostane levels (41.48±13.69 μg 8-ISOP/g liver. On the other hand, it significantly increased liver catalase activity (149.10±10.76 μmol/min/g liver, Vitamin C (2082.97±142.23 μg/g liver, Vitamin E (411.32±81.67 μg/g liver contents, and glutathione levels (2.13±0.42 mg GSH eq./g liver. Furthermore, 80% of astaxanthin absorption rates in all FFAP diet groups suggest FFAP is an effective form in astaxanthin absorption. Finally, astaxanthin was found to re-distribute to the liver and eyes in a dose dependent manner. Taken together, our results suggested that the appropriate addition of FFAP into high cholesterol diets increases liver anti-oxidative activity and reduces the concentration of lipid peroxidase and therefore, it may be beneficial as a material in developing healthy food.

  15. Technical and Economical Viability of Biodiesel Production using Waste Vegetable Edible Oil from the Oporto Metropolitan Area

    Energy Technology Data Exchange (ETDEWEB)

    Neves, A. [Petrogal, Lisboa (Portugal); Vilarinho, P. [CIRELIUS, Avintes (Portugal); C. Pinho, C. [Faculdade de Engenharia da Universidade do Porto (CEFT-DEMEGI) (Portugal)

    2009-07-01

    The technical and economical viability of using waste vegetable edible oils available in the Oporto Metropolitan Area (AMP) for biodiesel production, is analysed. For an yearly waste production of 20,000 t, the annual biodiesel production was calculated through the stoichiometric 1/1.05 (w/w) and the empirical 1/1 (w/w) transterification rate. Taking as reference the petrodiesel annual consumption values in the AMP, it was found that the rate of replacement of petrodiesel by biodiesel would change from 5.7 % to 2.2 % for the period of 1990 to 2003, due to the increase on the number of vehicles using diesel engines. The reduction of CO2 emissions for the replacement of 1 kg of petrodiesel is in the 2.4 kg to 3.2 kg range and the corresponding maximum financial benefit was of the order of 1.2 MEuro per year. The amounts of raw materials and input energy for processing were also determined for the 1990 to 2003 period, for transterification by the methylic and by the ethylic path; the methylic path is the best in all aspects. Through an energy balance for the annual production value of 20,000 t of biodiesel, it was found that the viability and sustainability of biodiesel production through waste oils is better than through virgin vegetable oils. There is a primary energy production of 18,917 tep for methyl ester and of 19,012 tep for the ethyl ester, equivalent to about 18,786 t of crude or 150,511 barrels of crude. Finally it is presented the economic and financial study for a 20,000 t/year biodiesel plant, working in a complementary regime of transterification and hydrosterification processes. The sensibility study allowed the comparison and evaluation of different scenarios. The economic viability of such biodiesel plant is highly dependent upon the cost of raw material and the biodiesel selling price. For an initial investment of 6,000,000 Euro, at the end of ten years it results in a NPV of about 28,000,000 Euro, with an internal rate of return (IRR) of 33 % and a

  16. Thermal ageing of steels; from expertise and understanding of the ageing mechanisms to a maintenance strategy for operating nuclear power plants

    International Nuclear Information System (INIS)

    Bezdikian, G.; Ould, P.

    2004-01-01

    Some parts of reactor coolant circuit on Nuclear PWR power plants, elbows on primary circuit, are made in cast duplex stainless steel material. It is now identify that the mechanical characteristic of this material should be decrease under thermal ageing mainly after a long time in operation in at reactor coolant circuit temperature conditions. The sensitiveness to the thermal ageing of these components is in relation with chemical composition and the ferrite content, especially the grade of Chromium equivalent (Ceq %Cr + %Si + %Mo). In the context of justification to maintain in operation on the plants these cat duplex components, an important programme of expertises was carried out on cast elbows after removing on the plants during the Steam Generators replacements (SGR). Several expertises, performed in the objective to understand the thermal ageing phenomenon and mechanism on cast components in service on plants, were permit to validate the prediction formulas established from a large database and programme in laboratories. The expertises were based on a lot of metallurgical, mechanical and chemical characteristics of components in operation Small Angle Neutrons Scattering (SANS), Thermal Electric Power (TEP), micro hardness and toughness measurement on small specimens from boat sample (CT10-5) The expertise carried out on one SG inlet elbows from DAMPIERRE, removed a during SGR after 100000 h in operation is shown, the toughness values are very high compared to the prediction formulas. The TEP measurements performed on the specimen cut off on two elbows and the ingots of the same material aged in laboratory in furnace, are very coherent; it is confirmed that this methodology is a good indicator to follow the ageing characteristic of material. The results of expertises on aged material are a mean of validation of the methodology applied on the file of demonstration of maintaining in operation of cast duplex stainless steel sensitive to thermal ageing. So the

  17. In-service and pre-service teacher education in IBSE: The ESTABLISH approach

    International Nuclear Information System (INIS)

    Ješková, Zuzana; Kireš, Marián; McLoughlin, Eilish; Finlayson, Odilla; Ottander, Christina; Ekborg, Margareta

    2015-01-01

    One of the main goals of the ESTABLISH 7fp project (available on line at http://www.establish-fp7.eu/) was the development and implementation of the professional development teacher education programmes (TEP) to support teachers in adopting inquiry-based strategies in their teaching. Within the project there was a model for in-service and pre-service teacher training in IBSE designed and implemented across 12 participating countries. The programme is based on 4 core elements and 4 additional elements that are built around the IBSE teaching units developed within the project. As accepted by ESTABLISH partners, all teacher training programmes include the minimum of the four elements, i.e. introduction to IBSE, industrial content knowledge, teacher as implementer and teacher as developer of IBSE teaching materials. There are also four additional elements designed in detail, i.e. ICT for IBSE, argumentation in the classroom, research and design projects for students, assessment of IBSE. These can be added to the programme optionally with regard to the level of teachers’ IBSE skills and current situation in education and teachers’ professional development within the country. This ESTABLISH model of TEP was followed in participating countries in order to change teachers’ attitudes from traditional ways of teaching towards adopting inquiry strategies and their successful implementation in the classroom. Within the face-to-face workshops teachers experienced and developed their inquiry based teaching strategies using specifically developed materials. In addition, the e-platform has been developed to provide on-line support. This platform provides educators and teachers with all the necessary materials for the training and IBSE teaching units and other teaching materials for teachers’ ongoing help. The teacher training programme was successfully implemented in Slovakia. There were two runs of teacher training workshops on IBSE already carried out. Moreover, the

  18. Dinitrogen fixation in aphotic oxygenated marine environments

    Directory of Open Access Journals (Sweden)

    Eyal eRahav

    2013-08-01

    Full Text Available We measured N2 fixation rates from oceanic zones that have traditionally been ignored as sources of biological N2 fixation; the aphotic, fully oxygenated, nitrate (NO3--rich, waters of the oligotrophic Levantine Basin (LB and the Gulf of Aqaba (GA. N2 fixation rates measured from pelagic aphotic waters to depths up to 720 m, during the mixed and stratified periods, ranged from 0.01 nmol N L-1 d-1 to 0.38 nmol N L-1 d-1. N2 fixation rates correlated significantly with bacterial productivity and heterotrophic diazotrophs were identified from aphotic as well as photic depths. Dissolved free amino acid amendments to whole water from the GA enhanced bacterial productivity by 2to 3.5 and N2 fixation rates by ~ 2 fold in samples collected from aphotic depths while in amendments to water from photic depths bacterial productivity increased 2 to 6 fold while N2 fixation rates increased by a factor of 2 to 4 illustrating that both BP an heterotrophic N2 fixation are carbon limited. Experimental manipulations of aphotic waters from the LB demonstrated a significant positive correlation between transparent exopolymeric particles (TEP concentration and N2 fixation rates. This suggests that sinking organic material and high carbon (C: nitrogen (N micro-environments (such as TEP-based aggregates or marine snow could support high heterotrophic N2 fixation rates in oxygenated surface waters and in the aphotic zones. Indeed, our calculations show that aphotic N2 fixation accounted for 37 to 75 % of the total daily integrated N2 fixation rates at both locations in the Mediterranean and Red Seas with rates equal or greater to those measured from the photic layers. Moreover, our results indicate that that while N2 fixation may be limited in the surface waters, aphotic, pelagic N2 fixation may contribute significantly to new N inputs in other oligotrophic basins, yet it is currently not included in regional or global N budgets.

  19. Iodine-123 and bromine-75 production and development program at Juelich

    International Nuclear Information System (INIS)

    Stoecklin, G.

    1985-01-01

    The iodine-123 and bromine-75 production and development program at the Nuclear Research Center in Juelich as of 1982 is described, and examples of recent 123 I- and 75 Br-analogue tracers that have been developed to the level of clinical trial are given. Iodine-123 is produced via the 127 I(d,6n) 123 Xe → 123 I process and by the 124 Te(p,2n) 123 I and 122 Te(d,n) 123 I reactions. These production methods are critically reviewed. Bromine-75-labeled benzodiazenes have been prepared for in vivo mapping of benzodiazepine receptor sites. The 7-( 75 Br)-5-(2-fluorophenyl)-1-methyl-1,3-dihydro-2H-1,4-benzodiazepine-2-one (BFB) was prepared with a specific activity of > 10 4 Ci/mmole. Finally, preparation and applications of the halogenated amino acid L-3-( 123 I)-iodo-α-methyltyrosine (IMT) and the analogous 75 Br compound (BMT) are reported. Both IMT and BMT have been successfully applied for pancreas imaging and tomography, and IMT has been used for imaging both melanotic and amelanotic malignant melanoma of the eye

  20. Synthesis and characterization of cadmium hydroxide nano-nest by chemical route

    International Nuclear Information System (INIS)

    Salunkhe, R.R.; Patil, U.M.; Gujar, T.P.; Lokhande, C.D.

    2009-01-01

    A facile chemical route based on room temperature chemical bath deposition (CBD) was developed to deposit the Cd(OH) 2 nano-nest. The growth mechanism follows two-stage crystallization with initial growth of nucleation centers, followed by subsequent anisotropic growth. The nano-nest morphological evolution of Cd(OH) 2 on different substrates has been carried out. These films have been characterized by the techniques; such as X-ray diffraction (XRD), scanning electron microscope (SEM), transmission electron microscope (TEM), optical absorption, contact angle measurement and thermoelectric power (TEP) measurements. The X-ray diffraction study revealed that the as deposited film consists of cadmium hydroxide (Cd(OH) 2 ) phase. The nano-nest consisted of wires with nearly uniform in dimensions, with diameter around 30 nm and length of few microns. As-deposited Cd(OH) 2 film used in this study showed water contact angle of 66 o . The optical bandgap was found to be 3.2 eV, with n-type electrical conductivity as confirmed from thermo-emf measurements.

  1. Phytoplankton aggregate formation: observations of patterns and mechanisms of cell sticking and the significance of exopolymeric material

    DEFF Research Database (Denmark)

    Kiørboe, Thomas; Hansen, Jorgen L. S.

    1993-01-01

    Flocculation of 'sticky' phytoplankton cells into rapidly sinking aggregates has been invoked as a mechanism explaining mass sedimentation of phytoplankton blooms in the ocean. Phytoplankton stickiness, defined as the probability of adhesion upon collision, is one key factor determining the poten......Flocculation of 'sticky' phytoplankton cells into rapidly sinking aggregates has been invoked as a mechanism explaining mass sedimentation of phytoplankton blooms in the ocean. Phytoplankton stickiness, defined as the probability of adhesion upon collision, is one key factor determining....... costatum at times excretes a solute substance that depresses flocculation. This may reduce cell losses from the euphotic zone during the growth phase due to flocculation and sedimentation. We demonstrated two different mechanisms of phytoplankton aggregate formation. In the diatom S. costatum, the cells...... are sticky in themselves, and coagulation depends on cell-cell sticking and does not involve mucus. Aggregates are composed solely of cells. Cells of the diatom Chaetoceros affinis, on the other hand, are not in themselves sticky. Transparent exopolymeric particles (TEP), produced by the diatom, cause...

  2. SWRO feed water quality improvement using subsurface intakes in Oman, Spain, Turks and Caicos Islands, and Saudi Arabia

    KAUST Repository

    Rachman, Rinaldi

    2014-10-01

    Water quality sampling and analysis conducted at four global locations, along the shorelines of the Arabian Sea, the Red Sea, the Mediterranean Sea, and the Caribbean Sea, demonstrated that subsurface intakes (wells) provide a robust degree of feed water treatment close to that provided by energy-intensive, conventional pretreatment systems. SDI values were reduced in virtually all cases to below 3. In vertical wells, from 70 to 100% of the TEP and 50% of the TOC and DOC found in natural seawater were removed in the aquifer. Reduction in the concentration of the organic fractions was selective based on molecular weight with the biopolymers nearly fully removed. Humic substances, building blocks, and light organic substances were removed at lesser percentages. Site geology was not the predominant factor affecting the removal efficiency, but the length of the flow path from the sea to the wells and the hydraulic retention time appear to be most significant. A comparison between vertical wells, a tunnel intake system, and a horizontal drain system at Alicante, Spain, demonstrated that the vertical wells performed best followed by the tunnel system, and the horizontal drain system which showed a breakthrough of algae and a very high organic carbon concentration. © 2014 Elsevier B.V.

  3. PRE-SERVICE EFL TEACHERS’ SELF-EFFICACY, THEIR ENGLISH PROFICIENCY AND THEIR PREPAREDNESS FOR TEACHING PRACTICUM PROGRAM

    Directory of Open Access Journals (Sweden)

    Himmawan Adi Nugroho

    2017-11-01

    Full Text Available Teacher training institutions hold an important role in preparing their students, the prospective or pre-service teachers, to become professional teachers based on their specific fields of study. This study examined the pre-service EFL teachers’ perception of self-efficacy and their English proficiency toward their preparedness for the teaching practicum program. The study used a survey research design using questionnaire as the instrument to get the pre-service EFL teachers’ perception of self-efficacy. The English proficiency data was from the TEP (test of English proficiency collected from the university’s language center where the pre-service EFL teachers took the test. Findings show that the pre-service EFL teachers have medium to high self-efficacy toward their teaching of EFL. They feel ready in spite of the fact they still have the feeling of anxiety. The courses related with the preparation to become a good and qualified EFL teachers and also for the teaching practicum program helped them to feel more confident.

  4. Nuclear energy for a sustainable development

    International Nuclear Information System (INIS)

    Guerrini, B.; Oriolo, F.

    2001-01-01

    Nuclear power currently produces over 628 M tep of the generated energy in 1997 avoiding about 1978 Mt of CO 2 emission and gives a significant contribution to reducing greenhouse gas emission. The competitive position of nuclear power might be strengthened, if market forces or government policy were able to give energy security and to control greenhouse gas, relying upon market mechanism and including environmental costs in economic analysis. In this case, taking into account the entire up-stream and down-stream chains for electricity generation, it can be seen that the greenhouse emission from nuclear plants, is lower than that of renewable energy chains. This paper investigates the potential role of nuclear power in global energy supply up to 2020 and analyzes the opportunities and the challenges for research, governments and nuclear industries of a broad nuclear power development in response to environmental concerns. The authors think that nuclear energy will have to compete in the same framework and under the same conditions as all other energy sources and so analyze the possibility of re-launching nuclear energy: it will have to couple nuclear safety and economic competitiveness [it

  5. TOTAL HIP ARTHROPLASTY IN OSTEOPETROSIS – REPORT OF A CASE

    Directory of Open Access Journals (Sweden)

    Zmago Krajnc

    2004-04-01

    Full Text Available Background. Authors introduced a case of a 27-year men with osteopetrosis with hip arthrosis. He has an autosomal – dominant form of disease and he needed total hip arthroplasty. There are seven cases described in literature with developed hip arthrosis by osteopetrosis.Methods. TEP implantation represents the greates surgical challenge in this patients, especially creation of intramedullary canal in femur and implantation of the femoral stem because of the very dense and brittle bones. This article describes the operative technique used in the case involved. It proved to be a very good solution.Results. The patient was released from the hospital ten days after implantation of total hip endoprosthesis. Three months after the operation the patient started to walk without aid of canes, he had non pain, and his range of motion was almost normal.Conclusions. Severe coxarthrosis is a rare complication of osteopetrosis. Great care must be taken with implantation of total hip endoprosthesis, especially with preparation of medular canal. It was recommended hand drilling under x-rays to exercise maximal control because reaming can cause false root of stem and greater probability of fracture.

  6. High temperature structural design and R and Ds for heat transport system components of FBR 'Monju'

    International Nuclear Information System (INIS)

    Sumikawa, Masaharu; Nakagawa, Yukio; Fukuda, Yoshio; Sukegawa, Masayuki; Ishizaki, Tairo.

    1980-01-01

    The machines and equipments of cooling system for the fast breeder prototype reactor ''Monju'' are operated in creep temperature region, and the upper limit temperature to apply the domestic structural design standard for nuclear machines and equipment is exceeded, therefore the guideline for high temperature structural design is being drawn up, reflecting the results of recent research and development, by the Power Reactor and Nuclear Fuel Development Corp. and others. In order to obtain the basic data for the purpose, the tests on the high temperature characteristics of main structural members and structural elements were carried out, and eight kinds of the inelastic structural analysis program ''HI-EPIC'' series were developed, thus the fundamental technologies of structural desigh in non-linear region were established. Also in the non-linear region, enormous physical quantities must be evaluated, and in the design method based on real elastic analysis, many design diagrams must be employed, therefore for the purpose of improving the reliability of evaluation, the automatic evaluation program ''HI-TEP'' was developed, and preparation has been made for the design of actual machines. The high temperature structural design in ''Monju'', the development of inelastic structural analysis program and high temperature structural analysis evaluation program, and the development of high temperature structures and materials are described. (Kako, I.)

  7. Hernia repair during endoscopic (laparoscopic) radical prostatectomy.

    Science.gov (United States)

    Stolzenburg, Jens-Uwe; Rabenalt, Robert; Dietel, Anja; Do, Minh; Pfeiffer, Heidemarie; Schwalbe, Steffen; Dorschner, Wolfgang

    2003-02-01

    We retrospectively reviewed our experience in performing endoscopic extraperitoneal radical prostatectomy (EERPE) and totally extraperitoneal (TEP) hernia repair in one procedure to evaluate its feasibility and safety. Based on our experience of 70 laparoscopic radical prostatectomies, a total of 60 patients underwent EERPE. Eight of these had 10 hernias repaired with Prolene mesh. The median total operating time for EERPE was 165 minutes. Mesh placement required an additional 15 minutes for a unilateral hernia and 25 minutes for bilateral hernias. The conversion rate and the reoperation rate were 0%. The median duration of vesical catheterization was 8.3 days. One patient required a blood transfusion. The most common minor complications, occurring in eight patients, were edema and hematoma of the penis. No wound infection occurred. The only major complication was a deep venous thrombosis in one patient. No additional complications developed in the hernioplasty group. We conclude that the extraperitoneal approach for radical prostatectomy allows concomitant inguinal hernia repair with a low morbidity rate and within an acceptable operating time.

  8. Preparation of hybrid biomaterials for bone tissue engineering

    Directory of Open Access Journals (Sweden)

    Vilma Conceição Costa

    2007-03-01

    Full Text Available Tissue engineering has evolved from the use of biomaterials for bone substitution that fulfill the clinical demands of biocompatibility, biodegradability, non-immunogeneity, structural strength and porosity. Porous scaffolds have been developed in many forms and materials, but few reached the need of adequate physical, biological and mechanical properties. In the present paper we report the preparation of hybrid porous polyvinyl alcohol (PVA/bioactive glass through the sol-gel route, using partially and fully hydrolyzed polyvinyl alcohol, and perform structural characterization. Hybrids containing PVA and bioactive glass with composition 58SiO2-33CaO-9P2O5 were synthesized by foaming a mixture of polymer solution and bioactive glass sol-gel precursor solution. Sol-gel solution was prepared from mixing tetraethoxysilane (TEOS, triethylphosphate (TEP, and calcium chloride as chemical precursors. The hybrid composites obtained after aging and drying at low temperature were chemically and morphologically characterized through infrared spectroscopy and scanning electron microscopy. The degree of hydrolysis of PVA, concentration of PVA solution and different PVA-bioglass composition ratios affect the synthesis procedure. Synthesis parameters must be very well combined in order to allow foaming and gelation. The hybrid scaffolds obtained exhibited macroporous structure with pore size varying from 50 to 600 µm.

  9. Tecnologias da informação e da comunicação para empoderamento: reflexões para a educação deste início de século

    Directory of Open Access Journals (Sweden)

    Márcia Lopes Reis

    2016-12-01

    Full Text Available Esta resenha trata das análises as relações e vivências sobre as relações da aprendizagem situada e os distintos momentos que a configuram em novos processos nos quais o trabalho compartilhado, e em rede, incrementa o arcabouço teórico e experiencial. O caráter inovador estaria na transição  da tradicional definição das TIC (‘tecnologias da informação e da comunicação’ às TAC (‘tecnologias de aprendizagem e conhecimento’ para alcançarem a condição de TEP (‘tecnologias de empoderamento e participação’. A vinculação desses conceitos à realidade do trabalho e, mais especificamente, à prática reflexiva desses sujeitos em seus lugares de atuação tornam possível o desenvolvimento de organizações  que aprendem, inclusive as instituições escolares.

  10. Planning projects for generation of electrical energy in the state of Sao Paulo, according to the degree of interference on air quality: an atmospheric qualification index using fuzzy sets; Ordenamento de projetos de geracao de energia eletrica no estado de Sao Paulo, segundo o grau de interferencia na qualidade do ar: um indice de qualificacao atmosferica (IQA) utilizando fuzzy sets

    Energy Technology Data Exchange (ETDEWEB)

    Dzedzej, Maira; Maciel, Jonas Fernandes; Santos, Afonso Henrique Moreira [IX Consultoria e Representacoes Ltda, Itajuba, MG (Brazil); Duarte, Pamella Santos [MS Consultoria Ltda, Itajuba, MG (Brazil); Universidade Federal de Itajuba (UNIFEI), MG (Brazil)

    2010-07-01

    Environmental issues are of great importance when assessing the feasibility and priority installation of new developments in electric power generation. In this sense, fuzzy logic can help define the regions that have favorable characteristics for receiving certain forms of generation. This study sought to order for the State of Sao Paulo, four kinds of generation projects: those using municipal solid waste gasification, those which make use of landfill gas with a change in firing (to reduce emissions), thermoelectric plants (TEPs) to bagasse (with 15% straw) and Small Hydropower (SHP). Such an ordering considered not only the type of generation but also the allocation of projects in the four regions, defined by regional vocations as defined by the State Water Resources Plan (Annex III of the State Law No. 9.034/94): Agriculture, Conservation, In Industrialization and Industrial. As a result, the use of fuzzy sets allowed the creation of a ranking of the alternatives (which totaled 14 possibilities), based exclusively on the degree of interference in air quality resulting from the installation of every form of generation. Such information may help the decision-making governing bodies to establish priorities in order, thereby accelerating the process of installation and operation of projects for generating electricity. (author)

  11. Tritium research activities in Korea

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Ki Jung, E-mail: kjjung@nfri.re.kr [National Fusion Research Institute, Yusung-gu, Daejeon 305-333 (Korea, Republic of); Yun, Sei-Hun, E-mail: shyun@nfri.re.kr [National Fusion Research Institute, Yusung-gu, Daejeon 305-333 (Korea, Republic of); Chang, Min Ho; Kang, Hyun-Goo; Chung, Dongyou; Cho, Seungyon; Lee, Hyeon Gon [National Fusion Research Institute, Yusung-gu, Daejeon 305-333 (Korea, Republic of); Chung, Hongsuk; Choi, Woo-Seok [Korea Atomic Energy Research Institute, Yusung-gu, Daejeon 305-353 (Korea, Republic of); Song, Kyu-Min; Moon, Chang-Bae [Korea Hydro & Nuclear Power Central Research Institute, Yusung-gu, Daejeon 305-343 (Korea, Republic of); Lee, Euy Soo [Dongguk University, Jung-gu, Seoul, 100-715 (Korea, Republic of); Cho, Jungho; Kim, Dong-Sun [Kongju National University, Cheonan, Chungnam, 330-717 (Korea, Republic of); Moon, Hung-Man [Daesung Industrial Gases Co., Ltd., Danwon-gu, Ansan-si, Gyeonggi-do, 425-090 (Korea, Republic of); Noh, Seung Jeong [Dankook University, Suji-gu, Yongin-si, Gyeonggi-do, 448-701 (Korea, Republic of); Ju, Hyunchul [Inha University, Nam-gu, Incheon, 402-751 (Korea, Republic of); Hong, Tae-Whan [Korea National University of Transportation, Chungju, Chungbuk, 380-702 (Korea, Republic of)

    2016-12-15

    Highlights: • NFRI, KAERI and KHNP CRI are major leading group for the ITER tritium SDS design; studying engineering, simulation of hydride bed, risk analysis (on safety, HAZOP), basic study, control logic & sequential operation, and others. KHNP has WTRF which gives favorable experiences for collaboration researchers. • Supplementary research partners: Five Universities (Dongguk University and POSTECH, Inha University, Dankook University, Korea National Transport University, and Kongju National University) and one industrial company (Daesung Industrial Gases Co., Ltd.); studying on basic and engineering, programming & simulation on the various topics for ITER tritium SDS, TEP, ISS, ADS, and etc. - Abstract: Major progress in tritium research in the Republic of Korea began when Korea became responsible for ITER tritium Storage and Delivery System (SDS) procurement package which is part of the ITER Fuel Cycle. To deliver the tritium SDS package, a variety of research institutes, universities and industry have respectively taken roles and responsibilities in developing technologies that have led to significant progress. This paper presents the current work and status of tritium related technological research and development (R&D) in Korea and introduces future R&D plans in the area of fuel cycle systems for fusion power generation.

  12. Development of a Multi-Model Ensemble Scheme for the Tropical Cyclone Forecast

    Science.gov (United States)

    Jun, S.; Lee, W. J.; Kang, K.; Shin, D. H.

    2015-12-01

    A Multi-Model Ensemble (MME) prediction scheme using selected and weighted method was developed and evaluated for tropical cyclone forecast. The analyzed tropical cyclone track and intensity data set provided by Korea Meteorological Administration and 11 numerical model outputs - GDAPS, GEPS, GFS (data resolution; 50 and 100 km), GFES, HWRF, IFS(data resolution; 50 and 100 km), IFS EPS, JGSM, and TEPS - during 2011-2014 were used for this study. The procedure suggested in this study was divided into two stages: selecting and weighting process. First several numerical models were chosen based on the past model's performances in the selecting stage. Next, weights, referred to as regression coefficients, for each model forecasts were calculated by applying the linear and nonlinear regression technique to past model forecast data in the weighting stage. Finally, tropical cyclone forecasts were determined by using both selected and weighted multi-model values at that forecast time. The preliminary result showed that selected MME's improvement rate (%) was more than 5% comparing with non-selected MME at 72 h track forecast.

  13. Biogas barometer

    International Nuclear Information System (INIS)

    2014-01-01

    The energy recovery of biogas has kept on increasing in the European Union in 2013: +10.2%. Almost 13.4 million tep (tonnes of oil equivalent) of biogas primary energy was produced but the growth of the biogas sector is decreasing (it was 16.9% between 2011 and 2012). The growth for the coming years is expected to fall further because of political decisions in some countries to limit the use of land for farming purposes and to manage the biogas sector more efficiently. Germany ranks first for the production of biogas primary energy with 6717 ktep followed by United Kingdom with 1824 ktep. 2 tables give the production of electricity and heat from biogas in the E.U. member states in 2012 and 2013. The total production of electricity and heat from biogas in the E.U. in 2013 reached 53327 GWh and 432 ktep respectively. A list reviews the most significant companies working in Europe in the sector of methanation, 10 companies are listed among which 2 are Italian: AB Energy (Gruppo AB), BTS Italia and 8 are German: MT Energie, Envitec Biogas AG, Biogas Weser-Ems, Planet Biogastechnik, Schmack Biogas GmbH, Weltec Biopower GmbH, UTS Biogastechnik (Anaergia Group), Bioconstruct and BTS Italia. (A.C.)

  14. Obtención de modelos de cálculo de sistemas provisionales de protección de borde mediante la técnica de Análisis Modal Operacional

    Directory of Open Access Journals (Sweden)

    González, M. N.

    2013-03-01

    Full Text Available In this work were obtained by Operational Modal Analysis (OMA vibration modes and frequencies associated with temporary of protection systems (TEPS built with planks of pine wood and steel poles. These systems have been evaluated analytically, using a finite element model (FEM. For the FEM we obtained the elastic constants of wood using ultrasound. The results of experimental and analytical assessment in the first vibration modes match in reasonable ways.

    En este trabajo se han obtenido experimentalmente mediante Análisis Modal Operacional (AMO los modos de vibración y las frecuencias asociadas de sistemas provisionales de protección de borde (SPPB fabricados con tablas de madera de pino silvestre y postes de sección tubular de acero. Los mismos sistemas se han evaluado analíticamente, usando un modelo de elementos finitos (MEF. Para el MEF se han obtenido las constantes elásticas de la madera mediante ultrasonidos. Los resultados de la evaluación experimental y analítica concuerdan en los primeros modos de vibración.

  15. Possible development of nuclear energy in the European Community and consequences of different reactor strategies

    International Nuclear Information System (INIS)

    Decressin, A.; Haytinck, B.; Orlowski, S.

    1974-01-01

    The Commission of the European Communities recommended to stimulate the development of the nuclear energy, in order to ensure in the middle or long term, a diversification of the energy supply sources of the Community. According to such a policy, nuclear energy could cover nearly 80% of the Community needs in electrical power in the year 2000 - these being estimated at 50% of total energy needs of the Community - and correspond to 1,3 billion tep for that year alone. In the year 2000, the installed nuclear capacity in the Community (i.e. nearly 1000 GWe) would imply the consumption of roughly 150.000 metric tons of natural uranium and necessitate 90.000 tons of SWU in enrichment services, whatever ''average'' strategy is considered for the period 1980 - 2000. The choices between these various strategies made by public or industrial decision centers, will be the result of a complex assessment of many factors. In any case, the flow of nuclear material between countries will remain very important and a Community nuclear self sufficiency based on breeding is not conceivable before the time at which new energy sources could be brought in effective uses

  16. Calculation of excitation functions of 1H and 3,4He induced reactions leading to 123I

    International Nuclear Information System (INIS)

    Rurarz, E.; Rymuza, P.

    1992-01-01

    About 25 nuclear reactions leading directly or indirectly (via parent 123 Xe or grandparent 123 Cs formation) to 123 I production have been suggested. However, no detailed study, especially on the cross section measurements for a large group of reactions potentially useful for 123 I production has been reported. On the basis of the good reproduction of the measured cross section values for the 123 Te(p,n) 123 I, 124 Te(p,2n) 123 I, 127 I(p,5n) 123 Xe → 123 I and 124 Xe(p,2n) 123 Cs → 123 Xe → 123 I reactions, we can conclude that the hybrid model of nuclear reactions in the form of the well developed computer code Overlaid ALICE makes it possible to calculate unknown cross sections even at intermediate bombarding energies. The code can be useful for estimating cross sections in order to plan experiments. The calculated data can be used for predictions of the reaction yields with a reasonable degree of confidence even when no measured data are available. For production of 123 I through different nuclear reactions we have computed excitation functions of the following reactions over a wide range of incident energies. Excitation functions have been plotted and the cross section values can be directly read from the plots for given bombarding energies. (author). 32 refs, 17 figs

  17. Estenosis de venas pulmonares post ablación por radiofrecuencia

    Directory of Open Access Journals (Sweden)

    Marcelo Guzzi

    2011-06-01

    Full Text Available Es importante estar atento ante la aparición de síntomas respiratorios luego de la realización de un procedimiento de ablación por radiofrecuencia en el tratamiento de la fibrilación auricular, pues la estenosis de venas pulmonares (EVP tiene una incidencia de entre 1 y 3% y puede aparecer hasta en los dos años posteriores al procedimiento1. Presentamos el caso de un paciente de 41 años de sexo masculino, que ingresó por un cuadro de hemoptisis y toracodinia de tres semanas de evolución, con antecedente de ablación por radiofrecuencia 6 meses antes de la admisión. La angiotomografía no evidenció tromboembolismo pulmonar (TEP y la angiorresonancia detectó hipoperfusión deI lóbulo superior del pulmón izquierdo (LSI. Debido a los antecedentes de ablación se solicitó angiotomografía de venas pulmonares, que evidenció estenosis de la vena del LSI. Se realizó estudio hemodinámico con dilatación y colocación de stent.

  18. Graphene oxide/MnO2 nanocomposite as destructive adsorbent of nerve-agent simulants in aqueous media

    Science.gov (United States)

    Šťastný, Martin; Tolasz, Jakub; Štengl, Václav; Henych, Jiří; Žižka, David

    2017-08-01

    Graphene oxide/MnO2 nanocomposite was prepared by thermal hydrolysis of potassium permanganate (KMnO4) and 2-chloroacetamide aqueous solutions with graphene oxide (GO) suspension. The synthesized samples were characterized by specific surface area (BET) and porosity determination (BJH), X-ray Diffraction (XRD) and high-resolution electron microscopes (HRSEM, HRTEM). These nanocomposites were used in an experimental evaluation of their adsorption activity with nerve agent simulants dimethyl methyl phosphonate (DMMP) and triethyl phosphate (TEP) in aqueous media. The nanocomposites exhibited enhanced adsorptive degradation ability compared to pure manganese oxide (MnO2) and GO. The GO amount in the nanocomposites affected their degradation activity substantially. The best adsorption efficiency was observed for samples with moderate GO amount. Three methods were used to observe the mechanism of the nerve-agent simulants deactivation: Gas chromatography with mass spectrometry (GC-MS), High-Performance Liquid Chromatography (HPLC) and in situ Infrared spectroscopy (FTIR). It was shown that the hydrolysis on the surface of prepared nanocomposites yields volatile primary alcohols (methanol and ethanol) as the main hydrolysis products.

  19. Adenovirus-mediated gene transfer of MMAC1/PTEN to glioblastoma cells inhibits S phase entry by the recruitment of p27Kip1 into cyclin E/CDK2 complexes.

    Science.gov (United States)

    Cheney, I W; Neuteboom, S T; Vaillancourt, M T; Ramachandra, M; Bookstein, R

    1999-05-15

    Genetic alterations in the MMAC1 tumor suppressor gene (also referred to as PTEN or TEP1) occur in several types of human cancers including glioblastoma. Growth suppression induced by overexpression of MMAC1 in cells with mutant MMAC1 alleles is thought to be mediated by the inhibition of signaling through the phosphatidylinositol 3-kinase pathway. However, the exact biochemical mechanisms by which MMAC1 exerts its growth-inhibitory effects are still unknown. Here we report that recombinant adenovirus-mediated overexpression of MMAC1 in three different MMAC1-mutant glioblastoma cell lines blocked progression from G0/G1 to S phase of the cell cycle. Cell cycle arrest correlated with the recruitment of the cyclin-dependent kinase (CDK) inhibitor, p27Kip1, to cyclin E immunocomplexes, which resulted in a reduction in CDK2 kinase activities and a decrease in levels of endogenous phosphorylated retinoblastoma protein. CDK4 kinase activities were unaffected, as were the levels of the CDK inhibitor p21Cip1 present in cyclin E immunocomplexes. Therefore, overexpression of MMAC1 via adenovirus-mediated gene transfer suppresses tumor cell growth through cell cycle inhibitory mechanisms, and as such, represents a potential therapeutic approach to treating glioblastomas.

  20. Dispersive Liquid-Liquid Microextraction Combined with Ultrahigh Performance Liquid Chromatography/Tandem Mass Spectrometry for Determination of Organophosphate Esters in Aqueous Samples

    Directory of Open Access Journals (Sweden)

    Haiying Luo

    2014-01-01

    Full Text Available A new technique was established to identify eight organophosphate esters (OPEs in this work. It utilised dispersive liquid-liquid microextraction in combination with ultrahigh performance liquid chromatography/tandem mass spectrometry. The type and volume of extraction solvents, dispersion agent, and amount of NaCl were optimized. The target analytes were detected in the range of 1.0–200 µg/L with correlation coefficients ranging from 0.9982 to 0.9998, and the detection limits of the analytes were ranged from 0.02 to 0.07 µg/L (S/N=3. The feasibility of this method was demonstrated by identifying OPEs in aqueous samples that exhibited spiked recoveries, which ranged between 48.7% and 58.3% for triethyl phosphate (TEP as well as between 85.9% and 113% for the other OPEs. The precision was ranged from 3.2% to 9.3% (n=6, and the interprecision was ranged from 2.6% to 12.3% (n=5. Only 2 of the 12 selected samples were tested to be positive for OPEs, and the total concentrations of OPEs in them were 1.1 and 1.6 µg/L, respectively. This method was confirmed to be simple, fast, and accurate for identifying OPEs in aqueous samples.

  1. Avances en el tratamiento del tromboembolismo pulmonar agudo

    Directory of Open Access Journals (Sweden)

    Peña Durán A

    2017-10-01

    Full Text Available Resume: We present a case of a 78-year-old male patient with a personal history of urothelial carcinoma, squamous cell carci- noma of the larynx and colon adenocarcinoma, who came to the emergency room because for about 3 months he had cough with hemoptotic sputum and increased basal dyspnea with moderate efforts until To make minimal efforts in the last 5-7 days and syncopal pictures in relation to cough and sputum mucohemoptotic accesses. Faced with risk factors for the development of a thromboembolic disease, personal history of cancer, combined with a compatible clinic, it was decided to request D-dimer analysis, which is 4228 ng/ml. As a result of the results, CT angiography is requested, de- scribing defects of repletion in segmental pulmonary arteries of upper lobe, middle and lower right suggestive of (TEP acute pulmonary thromboembolism. The study was completed with echo Doppler of lower limbs, abdominal ultra- sound, within normality, echocardiogram describing mild pulmonary hypertension without other relevant data. As a result of the diagnosis of PE, treatment is proposed, therefore, we are looking for advances in pharmacological treat- ment.

  2. [Antibiotic Susceptibility of Vibrio cholerae non O1/non O139 Serogroups Isolated from Environment in the Rostov Region].

    Science.gov (United States)

    Selyanskaya, N A; Trishina, A V; Verkina, L M; Arkhangelskaya, I V; Kruglikov, V D; Zlenko, Yu M

    2014-01-01

    Analysis of the antibioticograms of 22 strains of Vibrio cholerae non O1/non O139 serogroups (ctxA- tepA-) isolated from the environment in the Rostov Region in 2011 showed that all the cultures were susceptible to ciprofloxacin, aminoglycosides, ceftriaxone, trimetoprime/sulfamethoxazole and resistant to levomycetin and furazolidone. 32%, 18% and 9% of the isolates were resistant to tetracycline, rifampicin and nalidixic acid respectively. No strains of V. cholerae susceptible to all the tested antimicrobials were detected. 37% of the V. cholerae isolates was resistant to two antibacterials and the others showed multiple resistance and contained 3-6 r-determinants of antibiotic resistance. Since the antibiotic resistance genes in Vibrio cholerae non O1/non O139 serogroups are often located on mobile genetic elements (plasmids, interferons, SXT elements), many strains of such organisms, the same as the natural environment, could serve as reservoirs of antibiotic resistance. The presence of antibiotic resistance r-determinants in the investigated strains in various combinations, the antibiotic resistance variability in the isolates collected on the same territory within a relatively short period of time require monitoring of antibiotic susceptibility in them and the use of the antibiotic for the etiotropic therapy only in strict accordance with the antibioticogram of the culture isolated from the concrete patient.

  3. Solutions for increase of the NPP operators competitiveness in liberalised market

    International Nuclear Information System (INIS)

    Pliska, J.; Rubek, J.

    2004-01-01

    Safe, reliable and efficient operation of equipment is essential for profitable energy production. Ensuring conditions for the continuous safe operation is of primary importance in any nuclear power plant. However, if power production is considered, the important task is to operate the system optimally. This can be achieved by running the system close to its maximum efficiency. The paper describes the on-line monitoring systems integration into the overall plant information system and the process data warehouse built in the Dukovany Nuclear Power Plant and integration of the process data validation and thermal performance monitoring into it. The solution is based on the Industrial SQL server database and the InTouch human machine interface by Invensys' Wonderware, the RECON data validation package by ChemPlant Technology and TEP thermal performance monitoring package by I and C Energo. The solution unifies three different level of integration that should be taken into consideration. These are the data level, the functional level and the operational level. (author)

  4. A Mechanism Relating the Indian Ocean SSTs, ENSO, and the Nile Flow

    Science.gov (United States)

    Siam, M.; Eltahir, E. A.

    2012-12-01

    A significant fraction of the inter-annual variability in the Nile River flow is associated with ElNino Southern Oscillation (ENSO). Fluctuations of the Indian Ocean Sea Surface temperature (SST) are also associated with the Nile flow. Here, we investigate the intermediate role of Indian Ocean SSTs in the teleconnection between Nile flow and ENSO. Using the partial coherency analysis, we show that connection between the North and Middle of Indian Ocean SSTs and Nile flow is driven by ENSO. However, the South of Indian Ocean SSTs have an independent role from ENSO in shaping variability of Nile flow. This independence allows for indices of SSTs over the South of Indian Ocean and ENSO to explain about 60% of the variability of the Nile flow when they are used together. During ElNino events, the SSTs over the Indian Ocean increase following the warming of the Tropical Eastern Pacific (TEP), which forces a Matsuno-Gill circulation with enhanced westerlies winds over Indian Ocean that decreases the convergence of boundary layer air over the Upper Blue Nile (UBN) basin. On the other hand, the increased SSTs over South of Indian Ocean generate a cyclonic motion, which has a similar effect on the convergence of boundary layer air over the UBN. The proposed mechanism has an important implication in understanding the potential climate change impacts on the Nile flow induced by warming of over Indian Ocean and provide new indices for Nile flow forecast models.

  5. A Faster Parallel Algorithm and Efficient Multithreaded Implementations for Evaluating Betweenness Centrality on Massive Datasets

    Energy Technology Data Exchange (ETDEWEB)

    Madduri, Kamesh; Ediger, David; Jiang, Karl; Bader, David A.; Chavarria-Miranda, Daniel

    2009-02-15

    We present a new lock-free parallel algorithm for computing betweenness centralityof massive small-world networks. With minor changes to the data structures, ouralgorithm also achieves better spatial cache locality compared to previous approaches. Betweenness centrality is a key algorithm kernel in HPCS SSCA#2, a benchmark extensively used to evaluate the performance of emerging high-performance computing architectures for graph-theoretic computations. We design optimized implementations of betweenness centrality and the SSCA#2 benchmark for two hardware multithreaded systems: a Cray XMT system with the Threadstorm processor, and a single-socket Sun multicore server with the UltraSPARC T2 processor. For a small-world network of 134 million vertices and 1.073 billion edges, the 16-processor XMT system and the 8-core Sun Fire T5120 server achieve TEPS scores (an algorithmic performance count for the SSCA#2 benchmark) of 160 million and 90 million respectively, which corresponds to more than a 2X performance improvement over the previous parallel implementations. To better characterize the performance of these multithreaded systems, we correlate the SSCA#2 performance results with data from the memory-intensive STREAM and RandomAccess benchmarks. Finally, we demonstrate the applicability of our implementation to analyze massive real-world datasets by computing approximate betweenness centrality for a large-scale IMDb movie-actor network.

  6. MF/UF rejection and fouling potential of algal organic matter from bloom-forming marine and freshwater algae

    KAUST Repository

    Villacorte, Loreen O.

    2015-07-01

    Pretreatment with microfiltration (MF) or ultrafiltration (UF) membranes has been proposed for seawater reverse osmosis (SWRO) plants to address operational issues associated with algal blooms. Here, we investigated the MF/UF rejection and fouling potential of algal organic matter (AOM) released by common species of bloom-forming marine (Alexandrium tamarense and Chaetoceros affinis) and freshwater (Microcystis sp.) algae. Batch culture monitoring of the three algal species illustrated varying growth pattern, cell concentration, AOM released and membrane fouling potential. The high membrane fouling potential of the cultures can be directly associated (R2>0.85) with AOM such as transparent exopolymer particle (TEP) while no apparent relationship with algal cell concentration was observed. The AOM comprised mainly biopolymers (e.g., polysaccharides and proteins) and low molecular weight organic compounds (e.g., humic-like substances). The former were largely rejected by MF/UF membranes while the latter were poorly rejected. MF (0.4μm and 0.1μm pore size) rejected 14%-56% of biopolymers while conventional UF (100kDa) and tight UF (10kDa) rejected up to 83% and 97%, respectively. The retention of AOM resulted in a rapid increase in trans-membrane pressure (δP) over time, characterised by pore blocking followed by cake filtration with enhanced compression as illustrated by an exponential progression of δP. © 2015 Elsevier B.V.

  7. Partitioning and distribution of dissolved copper, cadmium and organic matter in Mediterranean marine coastal areas: The case of a mucilage event

    Science.gov (United States)

    Scoullos, Michael; Plavšić, Marta; Karavoltsos, Sotiris; Sakellari, Aikaterini

    2006-04-01

    Dissolved copper and cadmium partitioning and their interaction with organic matter were investigated in shallow coastal areas of the Aegean Sea (Eastern Mediterranean). The percentage of DGT-labile copper as for total dissolved copper ranged from 13 to 34% during summer and from 23 to 36% during winter, whereas the corresponding percentage for DGT-labile cadmium was higher in summer (38-68%), in comparison to winter (29-44%). The CCu was found to be 100-260 nM during summer while in winter the range was 42-430 nM. The corresponding CCd reached 27 and 45 nM, respectively. The mean TEP value in summer was high (208 μg/L xanthan equiv.), while in winter it reached 441 μg/L xanthan equiv., which indicates significant phytoplankton activity in winter, a feature occasionally observed in the stratified study areas after the breaking down of the thermocline/pycnocline, followed by consequent nutrient enrichment of the surface layers by nutrients accumulated in the sea bottom. A significant fraction of dissolved organic carbon (DOC) exhibited surface active properties and was determined as surface active substances (SAS) in mg/L eq. of nonionic surfactant Triton-X-100. Carbohydrates were also determined and they represented up to 33% of the DOC.

  8. Energy balance from Parana State: 1980-1993; Balanco energetico do Parana: 1980-1993

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-12-31

    This energetic balance from the Parana State, Brazil, includes the data referent to the year of 1993. It aims to be a planning tool to the public sector embraced to the energetic question and to orient productive investments to the private sector. It also shows the energetic information during the period of 1980-1993, presenting energetic streams of energetic primary and secondary sources, since its production to the final consumption, according to the main sectors of the economy in the Parana State. The balance is divided in seven chapters, as follows: resume - a synthetic analysis of the energetic sector evolution during the last 14 years and the consolidated data about production, consumption, etc concerning to 1993; energetic supply and demand; energetic interchange transformation centers; another energetic information; energy and socio economy; consolidated energetic balances; and annex - balance structure, information treatment, units, conversion table to medium tEP and specific masses and higher calorific capacities 5 figs., 7 graphs, 1 map, 92 tabs.

  9. Investigation of carbon segregation during low temperature tempering in a medium carbon steel

    International Nuclear Information System (INIS)

    Xiao, Y.; Li, W.; Zhao, H.S.; Lu, X.W.; Jin, X.J.

    2016-01-01

    Low temperature tempering is important in improving the mechanical properties of steels. In this study, the thermoelectric power method was employed to investigate carbon segregation during low temperature tempering ranging from 110 °C to 170 °C of a medium carbon alloyed steel, combined with micro-hardness, transmission electron microscopy and atom probe tomography. Evolution of carbon dissolution from martensite and segregation to grain boundaries/interfaces and dislocations were investigated for different tempering conditions. Carbon concentration variation was quantified from 0.33 wt.% in quenching sample to 0.15 wt.% after long time tempering. The kinetic of carbon diffusion during tempering process was discussed through Johnson-Mehl-Avrami equation. - Highlights: • The thermoelectric power (TEP) was employed to investigate the low temperature tempering of a medium carbon alloyed steel. • Evolution of carbon dissolution was investigated for different tempering conditions. • Carbon concentration variation was quantified from 0.33 wt.% in quenching sample to 0.15 wt.% after long time tempering.

  10. Carbon dioxide in electricity delivered to Swiss end-users. Final report; CO{sub 2}-Intensitaet des Stromabsatzes an Schweizer Endkunden. Schlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Jakob, M.; Volkart, K.; Widmer, D

    2009-07-15

    In this comprehensive final report, made by TEP Energy GmbH - Technology Economics Policy - Research and Advice - a spin-off company of ETH Zuerich for the Swiss gas and oil industries, the effective CO{sub 2} intensities involved in Swiss electricity consumption are calculated and discussed. The authors present details on how CO{sub 2} emissions should be calculated on the basis of figures both on Swiss power generation and, also, on electricity imports and exports in a European context. Daily and seasonal export-import balances are discussed. In particular the authors note that the actual production-mix for electricity in Switzerland should not be used as a basis for judging actual consumption. Three methods for viewing Swiss electricity consumption involving net and gross power export and import are introduced and discussed. The determination of the CO{sub 2} intensity of Swiss power is discussed, as are power demand profiles and international agreements. The results obtained using the three methods used are presented and discussed. Future developments are also examined. The report is completed with an appendix.

  11. Promoting the bio-cathode formation of a constructed wetland-microbial fuel cell by using powder activated carbon modified alum sludge in anode chamber.

    Science.gov (United States)

    Xu, Lei; Zhao, Yaqian; Doherty, Liam; Hu, Yuansheng; Hao, Xiaodi

    2016-05-20

    MFC centered hybrid technologies have attracted attention during the last few years due to their compatibility and dual advantages of energy recovery and wastewater treatment. In this study, a MFC was integrated into a dewatered alum sludge (DAS)- based vertical upflow constructed wetland (CW). Powder activate carbon (PAC) was used in the anode area in varied percentage with DAS to explore its influences on the performance of the CW-MFC system. The trial has demonstrated that the inclusion of PAC improved the removal efficiencies of COD, TN and RP. More significantly, increasing the proportion of PAC from 2% to 10% can significantly enhance the maximum power densities from 36.58 mW/m(2) to 87.79 mW/m(2). The induced favorable environment for bio-cathode formation might be the main reason for this improvement since the content of total extracellular polymeric substances (TEPS) of the substrate in the cathode area almost doubled (from 44.59 μg/g wet sludge to 87.70 μg/g wet sludge) as the percentage of PAC increased to 10%. This work provides another potential usage of PAC in CW-MFCs with a higher wastewater treatment efficiency and energy recovery.

  12. Physicochemical characteristics and sorption capacities of heavy metal ions of activated carbons derived by activation with different alkyl phosphate triesters

    Science.gov (United States)

    Wang, Jing; Liu, Hai; Yang, Shaokun; Zhang, Jian; Zhang, Chenglu; Wu, Haiming

    2014-10-01

    Five alkyl phosphate triesters (APTEs), including trimethyl phosphate (TMP), triethyl phosphate (TEP), triisopropyl phosphate (TPP), tributyl phosphate (TBP) and trioctyl phosphate (TOP), were used as activating agents for preparing activated carbons (AC-APTEs) with high surface acidity and metal ion sorption capacity. N2 adsorption/desorption isotherms, surface morphologies, elemental compositions, results of Boehm's titration and sorption capacities of heavy metal ions of the carbons were investigated. AC-APTEs contained much more acidic groups and exhibited much less surface area (phosphoric acid activation. For the AC-APTEs, AC-TOP had the highest surface area (488 m2/g), AC-TMP showed the highest yield (41.1%), and AC-TBP possessed the highest acidic groups (2.695 mmol/g), oxygen content (47.0%) and metal ion sorption capacities (40.1 mg/g for Ni(II) and 53.5 mg/g for Cd(II)). For the carbons, AC-APTEs showed much larger Ni(II) and Cd(II) sorption capacities than AC-PPA, except AC-TPP. The differences of the carbons in the physicochemical and sorption properties suggested surface chemistry of the carbons was the main factor influencing their sorption capacities whereas the pore structure played a secondary role.

  13. Reduced Prefrontal Short—Latency Afferent Inhibition in Older Adults and Its Relation to Executive Function: A TMS-EEG Study

    Directory of Open Access Journals (Sweden)

    Daniel M. Blumberger

    2017-05-01

    Full Text Available Combining transcranial magnetic stimulation (TMS with electroencephalography (EEG allows for the assessment of various neurophysiological processes in the human cortex. One of these paradigms, short-latency afferent inhibition (SAI, is thought to be a sensitive measure of cholinergic activity. In a previous study, we demonstrated the temporal pattern of this paradigm from both the motor (M1 and dorsolateral prefrontal cortex (DLPFC using simultaneous TMS–EEG recording. The SAI paradigm led to marked modulations at N100. In this study, we aimed to investigate the age-related effects on TMS-evoked potentials (TEPs with the SAI from M1 and the DLPFC in younger (18–59 years old and older (≥60 years old participants. Older participants showed significantly lower N100 modulation in M1–SAI as well as DLPFC–SAI compared to the younger participants. Furthermore, the modulation of N100 by DLPFC–SAI in the older participants correlated with executive function as measured with the Trail making test. This paradigm has the potential to non-invasively identify cholinergic changes in cortical regions related to cognition in older participants.

  14. The JNK pathway is a key mediator of Anopheles gambiae antiplasmodial immunity.

    Directory of Open Access Journals (Sweden)

    Lindsey S Garver

    Full Text Available The innate immune system of Anopheles gambiae mosquitoes limits Plasmodium infection through multiple molecular mechanisms. For example, midgut invasion by the parasite triggers an epithelial nitration response that promotes activation of the complement-like system. We found that suppression of the JNK pathway, by silencing either Hep, JNK, Jun or Fos expression, greatly enhanced Plasmodium infection; while overactivating this cascade, by silencing the suppressor Puckered, had the opposite effect. The JNK pathway limits infection via two coordinated responses. It induces the expression of two enzymes (HPx2 and NOX5 that potentiate midgut epithelial nitration in response to Plasmodium infection and regulates expression of two key hemocyte-derived immune effectors (TEP1 and FBN9. Furthermore, the An. gambiae L3-5 strain that has been genetically selected to be refractory (R to Plasmodium infection exhibits constitutive overexpression of genes from the JNK pathway, as well as midgut and hemocyte effector genes. Silencing experiments confirmed that this cascade mediates, to a large extent, the drastic parasite elimination phenotype characteristic of this mosquito strain. In sum, these studies revealed the JNK pathway as a key regulator of the ability of An. gambiae mosquitoes to limit Plasmodium infection and identified several effector genes mediating these responses.

  15. The Hitchhiker’s Guide to Adaptive Dynamics

    Directory of Open Access Journals (Sweden)

    Jacob Johansson

    2013-06-01

    Full Text Available Adaptive dynamics is a mathematical framework for studying evolution. It extends evolutionary game theory to account for more realistic ecological dynamics and it can incorporate both frequency- and density-dependent selection. This is a practical guide to adaptive dynamics that aims to illustrate how the methodology can be applied to the study of specific systems. The theory is presented in detail for a single, monomorphic, asexually reproducing population. We explain the necessary terminology to understand the basic arguments in models based on adaptive dynamics, including invasion fitness, the selection gradient, pairwise invasibility plots (PIP, evolutionarily singular strategies, and the canonical equation. The presentation is supported with a worked-out example of evolution of arrival times in migratory birds. We show how the adaptive dynamics methodology can be extended to study evolution in polymorphic populations using trait evolution plots (TEPs. We give an overview of literature that generalises adaptive dynamics techniques to other scenarios, such as sexual, diploid populations, and spatially-structured populations. We conclude by discussing how adaptive dynamics relates to evolutionary game theory and how adaptive-dynamics techniques can be used in speciation research.

  16. Energy Efficiency Improvements to Wundar Hall, a Historic Building on the Concordia Campus, Milwaukee, Wisconsin

    Energy Technology Data Exchange (ETDEWEB)

    Karman, Nathan

    2012-11-29

    The Forest County Potawatomi Community (FCPC or Community) implemented energy efficiency improvements to revitalize Wundar Hall, a 34,000 square foot (SF) building that was formerly used as a dormitory and is listed on the National Registry of Historic Places, into an office building. Wundar Hall is the first of many architecturally and historically significant buildings that the Community hopes to renovate at the former Concordia College campus, property on the near west side of Milwaukee that was taken into trust for the Community by the United States on July 10, 1990 (collectively, the Concordia Trust Property). As part of this project, which was conducted with assistance from the Department of Energy's Tribal Energy Program (TEP), the Community updated and/or replaced the building envelope, mechanical systems, the plumbing system, the electrical infrastructure, and building control systems. The project is expected to reduce the building's natural gas consumption by 58% and the electricity consumption by 55%. In addition, the project was designed to act as a catalyst to further renovation of the Concordia Trust Property and the neighborhood. The City of Milwaukee has identified redevelopment of the Concordia Trust Property as a Catalytic Project for revitalizing the near west side. The Tribe envisions a revitalized, mixed-use campus of community services, education, and economic developmen-providing services to the Indian community and jobs to the neighborhood.

  17. Organophosphorus flame retardants and plasticizers in the aquatic environment: A case study of the Elbe River, Germany.

    Science.gov (United States)

    Wolschke, Hendrik; Sühring, Roxana; Xie, Zhiyong; Ebinghaus, Ralf

    2015-11-01

    This study reports the occurrence and distribution of organophosphorus flame retardants and plasticizers (OPEs) in the Elbe and Rhine rivers. A special focus of this investigation concerns the potential impacts of a major flood event in 2013 on the OPE patterns and levels in the Elbe River. In this river, 6 of 13 OPEs were detected, with tris-ethyl-phosphate (TEP, 168 ± 44 ng/L), tris-1,3-dichloro-2-propyl-phosphate (TDCPP, 155 ± 14 ng/L) and tris-1-chloro-2-propyl phosphate (TCPP, 126 ± 14 ng/L) identified as the dominant compounds. Relative to previous studies, an increase in the concentrations and relative contributions of TDCPP to the total level of OPEs was observed, which was likely caused by its increased use as a replacement for the technical pentaBDE formulation. During the flood event, the concentrations of OPEs were similar to the normal situation, but the mass fluxes increased by a factor of approximately ten (∼16 kg/d normal versus ∼160 kg/d flood peak). No input hotspots were identified along the transects of the Elbe and Rhine rivers, and the mass flux of OPEs appeared to be driven by water discharge. Copyright © 2015 Elsevier Ltd. All rights reserved.

  18. Joint Planning Of Energy Storage and Transmission Considering Wind-Storage Combined System and Demand Side Response

    Science.gov (United States)

    Huang, Y.; Liu, B. Z.; Wang, K. Y.; Ai, X.

    2017-12-01

    In response to the new requirements of the operation mode of wind-storage combined system and demand side response for transmission network planning, this paper presents a joint planning of energy storage and transmission considering wind-storage combined system and demand side response. Firstly, the charge-discharge strategy of energy storage system equipped at the outlet of wind farm and demand side response strategy are analysed to achieve the best comprehensive benefits through the coordination of the two. Secondly, in the general transmission network planning model with wind power, both energy storage cost and demand side response cost are added to the objective function. Not only energy storage operation constraints and but also demand side response constraints are introduced into the constraint condition. Based on the classical formulation of TEP, a new formulation is developed considering the simultaneous addition of the charge-discharge strategy of energy storage system equipped at the outlet of the wind farm and demand side response strategy, which belongs to a typical mixed integer linear programming model that can be solved by mature optimization software. The case study based on the Garver-6 bus system shows that the validity of the proposed model is verified by comparison with general transmission network planning model. Furthermore, the results demonstrate that the joint planning model can gain more economic benefits through setting up different cases.

  19. Advanced LWIR hyperspectral sensor for on-the-move proximal detection of liquid/solid contaminants on surfaces

    Science.gov (United States)

    Giblin, Jay P.; Dixon, John; Dupuis, Julia R.; Cosofret, Bogdan R.; Marinelli, William J.

    2017-05-01

    Sensor technologies capable of detecting low vapor pressure liquid surface contaminants, as well as solids, in a noncontact fashion while on-the-move continues to be an important need for the U.S. Army. In this paper, we discuss the development of a long-wave infrared (LWIR, 8-10.5 μm) spatial heterodyne spectrometer coupled with an LWIR illuminator and an automated detection algorithm for detection of surface contaminants from a moving vehicle. The system is designed to detect surface contaminants by repetitively collecting LWIR reflectance spectra of the ground. Detection and identification of surface contaminants is based on spectral correlation of the measured LWIR ground reflectance spectra with high fidelity library spectra and the system's cumulative binary detection response from the sampled ground. We present the concepts of the detection algorithm through a discussion of the system signal model. In addition, we present reflectance spectra of surfaces contaminated with a liquid CWA simulant, triethyl phosphate (TEP), and a solid simulant, acetaminophen acquired while the sensor was stationary and on-the-move. Surfaces included CARC painted steel, asphalt, concrete, and sand. The data collected was analyzed to determine the probability of detecting 800 μm diameter contaminant particles at a 0.5 g/m2 areal density with the SHSCAD traversing a surface.

  20. Positron emission tomography with 18 F-FDG and ovarian cancer; Tomographie par emission de positons par {sup 18}F-FDG et cancer de l'ovaire

    Energy Technology Data Exchange (ETDEWEB)

    Corone, C.; Sarandi, F.; Gutman, F.; Collignon, M.A.; Wartski, M.; Alberini, J.L.; Pecking, A.P. [Centre de Lutte Contre le Cancer Rene Huguenin, Service de Medecine Nucleaire, 92 - Saint-Cloud (France)

    2004-10-01

    Ovarian carcinoma is the most frequent gynecologic cancer and its prognosis is severe, despite chemo sensibility, with a global 5 years survival around 50 %. This poor prognosis is related to initial extend of the disease as well as to high frequency of residual disease after initial treatment and recurrences. In those situations, efficacy of conventional imaging is usually low and FDG PET can be useful. French national cancer centres federation guidelines for clinical practice (SORs) recommend FDG TEP as a B2 proof level option when recurrence or metastasis is suspected. FDG PET seems also useful, in limited series, to improve initial staging and might be an alternative to second look laparoscopy residual disease evaluation. Because microscopic disease might be not detected, predictive positive value of FDG PET should be considered more reliable than its negative predictive value. In this carcinoma, due to the proximity of intestinal and urinary tract potential artefacts and because precise disease location is of high prognosis and therapeutic value, PET - CT technology seems of particular interest. (author)

  1. The weak lensing analysis of the CFHTLS and NGVS RedGOLD galaxy clusters

    Science.gov (United States)

    Parroni, C.; Mei, S.; Erben, T.; Van Waerbeke, L.; Raichoor, A.; Ford, J.; Licitra, R.; Meneghetti, M.; Hildebrandt, H.; Miller, L.; Côté, P.; Covone, G.; Cuillandre, J.-C.; Duc, P.-A.; Ferrarese, L.; Gwyn, S. D. J.; Puzia, T. H.

    2017-12-01

    An accurate estimation of galaxy cluster masses is essential for their use in cosmological and astrophysical studies. We studied the accuracy of the optical richness obtained by our RedGOLD cluster detection algorithm tep{licitra2016a, licitra2016b} as a mass proxy, using weak lensing and X-ray mass measurements. We measured stacked weak lensing cluster masses for a sample of 1323 galaxy clusters in the Canada-France-Hawaii Telescope Legacy Survey W1 and the Next Generation Virgo Cluster Survey at 0.2z<0.5, in the optical richness range 10-70. We tested different weak lensing mass models that account for miscentering, non-weak shear, the two-halo term, the contribution of the Brightest Cluster Galaxy, and the intrinsic scatter in the mass-richness relation. We calculated the coefficients of the mass-richness relation, and of the scaling relations between the lensing mass and X-ray mass proxies.

  2. Systeme microfluidique d'analyse sanguine en temps reel pour l'imagerie moleculaire chez le petit animal

    Science.gov (United States)

    Convert, Laurence

    De nouveaux radiotraceurs sont continuellement développés pour améliorer l'efficacité diagnostique en imagerie moléculaire, principalement en tomographie d'émission par positrons (TEP) et en tomographie d'émission monophotonique (TEM) dans les domaines de l'oncologie, de la cardiologie et de la neurologie. Avant de pouvoir être utilisés chez les humains, ces radiotraceurs doivent être caractérisés chez les petits animaux, principalement les rats et les souris. Pour cela, de nombreux échantillons sanguins doivent être prélevés et analysés (mesure de radioactivité, séparation de plasma, séparation d'espèces chimiques), ce qui représente un défi majeur chez les rongeurs à cause de leur très faible volume sanguin (˜1,4 ml pour une souris). Des solutions fournissant une analyse partielle sont présentées dans la littérature, mais aucune ne permet d'effectuer toutes les opérations dans un même système. Les présents travaux de recherche s'insèrent dans le contexte global d'un projet visant à développer un système microfluidique d'analyse sanguine complète en temps réel pour la caractérisation des nouveaux radiotraceurs TEP et TEM. Un cahier des charges a tout d'abord été établi et a permis de fixer des critères quantitatifs et qualitatifs à respecter pour chacune des fonctions de la puce. La fonction de détection microfluidique a ensuite été développée. Un état de l'art des travaux ayant déjà combiné la microfluidique et la détection de radioactivité a permis de souligner qu'aucune solution existante ne répondait aux critères du projet. Parmi les différentes technologies disponibles, des microcanaux en résine KMPR fabriqués sur des détecteurs semiconducteurs de type p-i-n ont été identifiés comme une solution technologique pour le projet. Des détecteurs p-i-n ont ensuite été fabriqués en utilisant un procédé standard. Les performances encourageantes obtenues ont mené à initier un projet de ma

  3. Contribution of transcranial magnetic stimulation to assessment of brain connectivity and networks.

    Science.gov (United States)

    Hallett, Mark; Di Iorio, Riccardo; Rossini, Paolo Maria; Park, Jung E; Chen, Robert; Celnik, Pablo; Strafella, Antonio P; Matsumoto, Hideyuki; Ugawa, Yoshikazu

    2017-11-01

    The goal of this review is to show how transcranial magnetic stimulation (TMS) techniques can make a contribution to the study of brain networks. Brain networks are fundamental in understanding how the brain operates. Effects on remote areas can be directly observed or identified after a period of stimulation, and each section of this review will discuss one method. EEG analyzed following TMS is called TMS-evoked potentials (TEPs). A conditioning TMS can influence the effect of a test TMS given over the motor cortex. A disynaptic connection can be tested also by assessing the effect of a pre-conditioning stimulus on the conditioning-test pair. Basal ganglia-cortical relationships can be assessed using electrodes placed in the process of deep brain stimulation therapy. Cerebellar-cortical relationships can be determined using TMS over the cerebellum. Remote effects of TMS on the brain can be found as well using neuroimaging, including both positron emission tomography (PET) and functional magnetic resonance imaging (fMRI). The methods complement each other since they give different views of brain networks, and it is often valuable to use more than one technique to achieve converging evidence. The final product of this type of work is to show how information is processed and transmitted in the brain. Published by Elsevier B.V.

  4. Scaling Techniques for Massive Scale-Free Graphs in Distributed (External) Memory

    KAUST Repository

    Pearce, Roger

    2013-05-01

    We present techniques to process large scale-free graphs in distributed memory. Our aim is to scale to trillions of edges, and our research is targeted at leadership class supercomputers and clusters with local non-volatile memory, e.g., NAND Flash. We apply an edge list partitioning technique, designed to accommodate high-degree vertices (hubs) that create scaling challenges when processing scale-free graphs. In addition to partitioning hubs, we use ghost vertices to represent the hubs to reduce communication hotspots. We present a scaling study with three important graph algorithms: Breadth-First Search (BFS), K-Core decomposition, and Triangle Counting. We also demonstrate scalability on BG/P Intrepid by comparing to best known Graph500 results. We show results on two clusters with local NVRAM storage that are capable of traversing trillion-edge scale-free graphs. By leveraging node-local NAND Flash, our approach can process thirty-two times larger datasets with only a 39% performance degradation in Traversed Edges Per Second (TEPS). © 2013 IEEE.

  5. Initiation of Stress Corrosion Cracking of 26Cr-1Mo Ferritic Stainless Steels in Hot Chloride Solution

    International Nuclear Information System (INIS)

    Kwon, H. S.; Hehemann, R. F.

    1987-01-01

    Elongation measurements of 26Cr-1Mo ferritic stainless steels undergoing stress corrosion in boiling LiCl solution allow the induction period to be distinguished from the propagation period of cracks by the deviation of elongation from the logarithmic creep law. Localised corrosion cells are activated exclusively at slip steps by loading and developed into corrosion trenches. No cracks have developed from the corrosion trenches until the induction period is exceeded. The induction period is regarded as a time for localised corrosion cells to achieve a critical degree of occlusion for crack initiation. The repassivation rate of exposed metal by creep or emergence of slip steps decreases as the load increases and is very sensitive to the microstructural changes that affect slip tep height. The greater susceptibility to stress corrosion cracking of either prestrained or grain coarsened 26Cr-1Mo alloy compared with that of mill annealed material results from a significant reduction of repassivation rate associated with the increased slip step height. The angular titanium carbonitrides particles dispersed in Ti-stabilized 26Cr-1Mo alloy have a detrimental effect on the resistance to stress corrosion cracking

  6. Correlation Among Students’ Family Background, Academic Performance in Junior High School, and Senior High School Tracking in Taiwan

    Directory of Open Access Journals (Sweden)

    Ming-Fu Huang

    2014-12-01

    Full Text Available There were numerous previous studies on educational tracking. However, most of the data adopted in these studies were collected a decade ago, involving sample population 20-64 years of age. Among them, many elderly samples had undergone senior high school tracking in the early years. The present study used the data of students and parents from the 3rd wave (2005 of the Taiwan Education Panel Survey (TEPS. A path analysis was conducted to investigate the inequality of opportunities involved in the influence of student family background on educational tracking at the senior high school stage. The results show: although the overall percentage of junior high school graduates entering advanced levels was approximately 100% and almost all students of different family backgrounds entered advanced levels, the most crucial factor among those affecting educational tracking of senior high school stage was students’ academic performance during junior high school. Students with higher family socioeconomic status and fewer siblings showed better academic performance in junior high schools, and consequently had higher possibilities of entering public senior high schools leading to a more promising future. This indicates that though the inequality in the quantity of opportunities approached 0, the inequality in the quality of opportunities still remained, which fails to support the hypothesis of the maximally maintained inequality of educational opportunity (MMI; however, the result supports the hypothesis of the effectively maintained inequality of educational opportunity (EMI.

  7. Impacto de la envolvente en la demanda de energía en calefacción residencial de la región metropolitana de La Plata, tomando como caso testigo el reciclado energético de una vivienda

    Directory of Open Access Journals (Sweden)

    María de la Paz Diulio

    Full Text Available Resumen El área metropolitana de La Plata representa el 1,6% de las viviendas de la Argentina. A partir del análisis del reciclado de una vivienda se construyen indicadores básicos con el fin de proponer una metodología que facilite la extrapolación, a nivel regional, del impacto que causaría un programa de eficiencia energética en viviendas. Se exponen desde el nivel micro a macro los resultados obtenidos en un contexto de carestía energética y recurrentes crisis en la oferta de combustibles y electricidad en la Argentina. La mejora en la resistencia térmica de muros y techos en todo el parque residencial de La Plata conllevaría a una reducción del 12% de la energía consumida en calefacción, y un ahorro de 30.000 TEP/año. Se concluye que la incidencia que implica la colocación de aislación adicional respecto del costo de la construcción justifica su uso, resolviendo parcialmente la falta de combustibles en el país, reduciendo gastos fijos en la vivienda, otorgando confort térmico a los usuarios y generando reactivación del sector de la construcción.

  8. A systematic study on the effect of electron beam irradiation on structural, electrical, thermo-electric power and magnetic property of LaCoO{sub 3}

    Energy Technology Data Exchange (ETDEWEB)

    Benedict, Christopher J. [Department of Physics, Manipal Institute of Technology, Manipal University, Manipal 576104 (India); Rao, Ashok, E-mail: ashokanu_rao@rediffmail.com [Department of Physics, Manipal Institute of Technology, Manipal University, Manipal 576104 (India); Sanjeev, Ganesh [Microtron Centre, Department of Studies in Physics, Mangalore University, Mangalagangotri 74199, DK, Karnataka (India); Okram, G.S. [UGC-DAE Consortium for Scientific Research, University Campus, Khandwa Road, Indore 452017 (India); Babu, P.D. [UGC-DAE Consortium for Scientific Research, R5 Shed, Bhabha Atomic Research Centre, Mumbai 400085 (India)

    2016-01-01

    In this communication, the effect of electron beam irradiation on the structural, electrical, thermo-electric power and magnetic properties of LaCoO{sub 3} cobaltites have been investigated. Rietveld refinement of XRD data reveals that all samples are single phased with rhombohedral structure. Increase in electrical resistivity data is observed with increase in dosage of electron beam irradiation. Analysis of the measured electrical resistivity data indicates that the small polaron hopping model is operative in the high temperature regime for all samples. The Seebeck coefficient (S) of the pristine and the irradiated samples exhibits a crossover from positive to negative values, and a colossal value of Seebeck coefficient (32.65 mV/K) is obtained for pristine sample, however, the value of S decreases with increase in dosage of irradiation. The analysis of Seebeck coefficient data confirms that the small polaron hopping model is operative in the high temperature region. The magnetization results give clear evidence of increase in effective magnetic moment due to increase in dosage of electron beam irradiation. - Highlights: • Pure and irradiated compounds follow SPH model in high temperature range. • Colossal thermoelectric power is observed at low temperatures. • High temperature TEP data follows SPH model. • Curie temperature decreases with electron irradiation. • Magnetization shows increased magnetic moment due to electron beam irradiation.

  9. Facts and figures in 2005 for energy; Faits et chiffres en 2005

    Energy Technology Data Exchange (ETDEWEB)

    Lavergne, R.; Meuric, L.; Scherrer, S.; Paquel, V.; Louati, S.; Thienard, H. [Ministere de l' Economie, des Finances et de l' Industrie, Observatoire de l' Energie, 75 - Paris (France). Direction Generale de L' Energie et des Matieres Premieres

    2006-08-15

    The global consumption of primary energy reached 276.5 Mtep (1 tep: 1 equivalent ton of oil) in 2005 in France, it means a slight increase of 0.3% compared with last year, the gross national product evolved by +1.4% meanwhile. The consumption of energy has decreased in all sectors: -0.6% in industry, -2.7% in agriculture and -0.8% in transport, except in domestic uses: +0.6%. The sale of road fuels has decreased by -1%, among these fuels: the consumption of diesel keeps on increasing +0.9% while that of car gas confirms its drop: -6%. The consumption of bio-fuels has had a sharp increase: +18%. For the first time since 1981 the national production of primary energy has not increased (-0.2%) and the country's independence energy rate is now below 50% (49.8%). As for electrical power production, the poor rains of 2005 have led to a drop in the hydro-power production (-13%) that has been counterbalanced by an increase of the fossil-fueled power plants' production (+11%). The consequence is that the emissions of CO{sub 2} have slightly increased (+0.3%). (A.C.)

  10. A influência da crioterapia na dor e edema induzidos por sinovite experimental The cryotherapy influence on pain and edema induced by experimental synovitis

    Directory of Open Access Journals (Sweden)

    Natália Boneti Moreira

    2011-03-01

    Full Text Available O objetivo deste estudo foi analisar a influência da crioterapia na dor e edema advindos de sinovite induzida em ratos. Foram utilizados 12 ratos, distribuídos em dois grupos: Controle (GC - submetido à indução de sinovite no joelho direito, e não tratado; e Tratamento (GT - submetido à sinovite no joelho direito, e tratado com crioterapia. Para induzir a lesão, foi injetado no espaço tíbio-femoral formalina 5%. Para avaliação da dor foi utilizado o teste de incapacidade funcional, que avaliou a dor durante a marcha do animal (tempo de elevação da pata - TEP; e para quantificar o edema foi utilizado um paquímetro metálico, na região da interlinha do joelho. As avaliações ocorreram antes da injeção de formalina (AV1, 1 (AV2 e 2 horas (AV3 após. Após 10 minutos da lesão, o membro posterior direito foi submerso em água com gelo, à 5ºC por 20 minutos. A avaliação do TEP mostrou aumento de 194,03% (AV2 e 169,26% (AV3 para GC; e 134,25% (AV2 e 103,13% (AV3 para GT, com relação à AV1. Na comparação entre os grupos, em AV3, houve diminuição significativa para GT. A avaliação do edema mostrou aumento do diâmetro, para GC de 39,15% (AV2 e 42,39% (AV3; e 27,91% (AV2 e 14,50% (AV3 para GT, tendo como referência AV1; sendo que apenas GT apresentou diminuição significativa entre AV2 e AV3. Conclui-se que os efeitos em curto prazo, da crioterapia, foram significativos para reduzir a dor e edema, em ratos submetidos à indução de sinovite.The Aim of this study was to examine the influence of cryotherapy on pain and swelling in an induced synovitis in rats. A total of 12 rats were allocated into two groups: the control (CG - underwent the synovitis induction in his right knee, and not treated, and treatment (TG - synovitis in his right knee, and treated with cryotherapy. To induce injury, was injected into the tibio-femoral joint space 5% formalin. For the pain assessment was used the functional incapacitation test

  11. 重複觀測量數之分析:多群體多變項線性成長模式的估計Data Analysis of Repeated Measures: Estimating a Multi-Group Multivariate Linear Growth Model

    Directory of Open Access Journals (Sweden)

    溫福星 Fur-Hsing Wen

    2012-03-01

    Full Text Available 本研究利用「台灣教育長期追蹤資料庫」的一般分析能力與數學分析能力的四波調查結果,配合男、女學生樣本進行多群體多條追蹤資料的線性成長模式估計。在考慮重複觀測資料誤差項在不同時點的變異數非同質與不同時點間的共變數非獨立情況下,以及男、女學生的不同成長軌跡,將誤差項結構設為無限制結構,利用虛擬變項交互項法與虛擬變項多樣本法同時估計不同性別、不同能力的線性成長軌跡變化。由於全部追蹤資料樣本存在遺失值的情形,本研究以階層線性模式(hierarchical linear modeling, HLM)軟體對完整資料2,806位學生進行分析,其估計結果發現,在完整資料的兩條成長軌跡模式中,男、女學生誤差項共變異數矩陣結構相同,但線性成長軌跡不恆等。除此之外,本文並對競爭模式比較的結果在文章最後進行討論並提出相關的建議。 This paper demonstrates the data analysis of the repeated measures from the Taiwan Education Panel Survey (TEPS. Based on the four data waves on the TEPS, we consider two abilities (general and mathematic and two population groups (male and female students to construct a multi-group multivariate linear growth model. Because the two-group multivariate repeated measures belong to the different populations and the different research variables, the residual terms of linear growth models may imply heterogeneity of the error covariance structure. We treat the error covariance structure as an unrestricted structure to compare the various types of models. The results from the HLM on the complete data (2,806 students reveal that the male and female students in this study have the same error covariance structure but have distinct linear growth trajectories. In addition, comparisons of the competitive models and related suggestions are discussed in the results and conclusion

  12. Sarcoma da Artéria Pulmonar — dificuldades diagnósticas e terapêuticas

    Directory of Open Access Journals (Sweden)

    Sofia Neves

    2003-01-01

    Full Text Available RESUMO: O Sarcoma da Artéria Pulmonar é um tumor raro, apresentando-se com sinais e sintomas inespecíficos, simulando por vezes o Tromboembolismo Pulmonar (TEP, o que torna o seu diagnóstico difícil e tardio.A este propósito os autores apresentam um caso de um homem de 59 anos, ex-fumador, internado por dispneia de esforço, toracalgia e sintomas gerais.Portador de uma radiografia e TAC torácicas, ambas evidenciando imagens sugestivas de Trombose da Artéria Pulmonar Direita.Analiticamente e antes de qualquer terapêutica: Inibidor Lúpico ↑ e anticardiolipina IgM +.Presumido diagnóstico inicial de TEP crónico em doente com provável Síndroma de Hipercoaguabilidade, iniciou terapêutica hipocoagulante, com melhoria.Reinternado 2 meses após alta por agravamento clínico e radiológico. Proposto e aceite para Tromboendarterectomia Pulmonar, sob circulação extracorporal e paragem cardiocirculatória em hipotermia profunda (18 ºC. Durante a cirurgia constatou-se a presença de «mega-artérias pulmonares» preenchidas por massa trombosada que se estendia às ramificações arteriais segmentares. Após a exérese dessa massa houve necessidade de realizar Pneumectomia direita por hemorragia progressiva incontrolável.Veio a falecer ao 7.º dia de pós-operatório, por ARDS em pulmão único.Resultado Anatomopatológico: Sarcoma da Artéria Pulmonar com Metastização Pulmonar e Pleural.REV PORT PNEUMOL IX (1: 41-51 ABSTRACT: Primary Pulmonary Artery Sarcoma is a rare entity, which shares some clinical features with Thromboembolic Pulmonary Disease (TEPD, complicating differential diagnosis.The authors report a Clinical Case of a Primary Pulmonary Artery Sarcoma in a 59 years old man, admitted with a history of dyspnoea on exertion, chest pain and general symptoms. Chest X-ray, Computed Tomography Scan, Angiographies and Magnetic Resonance Imaging

  13. Tratamento do tromboembolismo pulmonar maciço por fragmentação percutânea do trombo Treatment of massive pulmonary embolism by percutaneous fragmentation of the thrombus

    Directory of Open Access Journals (Sweden)

    Marco Antonio Oliveira Barbosa

    2007-03-01

    Full Text Available OBJETIVOS: Avaliar a segurança e a eficácia da fragmentação percutânea do trombo (FPT no tromboembolismo pulmonar (TEP maciço em pacientes com contra-indicação à administração de trombolíticos. MÉTODOS: Entre julho de 1999 e agosto de 2005, 10 pacientes (7 homens, 3 mulheres, idade média de 57±18 anos com TEP maciço e contra-indicação à administração de trombolíticos foram submetidos a FPT. A saturação arterial de oxigênio (Sat.O2, índice de Walsh (IW, pressão arterial pulmonar média (PAP, pressão arterial sistêmica média (PAS e função ventricular direita (FVD ao ecocardiograma Doppler transtorácico foram avaliados pré e pós-procedimento. Foi realizada análise estatística por meio do teste de Wilcoxon pareado, sendo p significativo quando OBJECTIVES: To evaluate the safety and efficacy of percutaneous thrombus fragmentation (PTF for massive pulmonary embolism (PE in patients with contraindications to the administration of thrombolytics. METHODS: Between July 1999 and August 2005, 10 patients (7 males, 3 females, age 57±18 years with massive PE and contraindications to the administration of thrombolytics underwent PTF. A transthoracic doppler echocardiogram was used to evaluate arterial oxygen saturation (Sat O2, the Walsh index (WI, mean pulmonary artery pressure (PAP, mean systemic blood pressure (SBP and right ventricular function (RVF before and after the procedure. Statistical analysis was conducted using the paired Wilcoxon test, of which p was significant when < 0.05. RESULTS: After the PTF treatment there was an improvement in Sat. O2 [87.4 ± 1.3% vs 92.3 ± 3.1% (p < 0.001], WI [6.4 ± 1.07 vs 4.4 ± 1.42 (p = 0.003], PAP [31.8 ± 4.6 mmHg vs 25.5 ± 3.4 mmHg (p < 0.001] and SBP [73.9 ± 8.7 vs 85 ± 8.3 (p = 0.001. The ten patients had severe RVF before the percutaneous treatment; however, within 10 days after PTF, 8 presented normal or discrete function and 1 presented mitigated function. There

  14. Application of ceramic membranes for seawater reverse osmosis (SWRO) pre-treatment

    KAUST Repository

    Hamad, Juma

    2013-05-30

    conform to the requirement of SDI < 3 needed for SWRO feed. The removal of bacteria corresponded to 3.7 log removal, while turbidity improved from 0.6 NTU (feed) to 0.05 NTU (permeate). However, ceramic membranes showed low recovery after BW and significant increase of trans-membrane pressure (TMP) during operation with the membrane alone, without coagulation. This increase of TMP can be related to the presence of sticky polysaccharide-like material called transparent exopolymers particles (TEP) that are known to be in abundance in seawater and contribute to organic fouling and eventually bio fouling. TEP showed resistance and stickiness on the membrane surface (AAO100) even after aggressive BW. This may be responsible for the low flux recovery observed after BW in both bench-scale and pilot experiments. To improve membrane filtration, coagulation was performed by using iron III chloride. Continuous addition of iron III chloride (4 mg/L Fe) through inline coagulation showed almost complete control of irreversible fouling and reduces reversible fouling after 30 h of operation, based on 2.5 h intervals of filtration cycle. Also, biopolymers removal improved to 51-71%, with improved removal at low pH, while for stabilization of flux, a dose of 1 mg/L Fe3+ was sufficient. Reduction of high molecular weight Natural organic matters (NOM) is essential for controlling or reducing irreversible fouling. Therefore, coagulation is recommended for smooth operation of ceramic membranes and for provision of low-fouling feed water, prior to SWRO membranes. © 2013 Copyright Balaban Desalination Publications.

  15. The Geohazards Exploitation Platform: an advanced cloud-based environment for the Earth Science community

    Science.gov (United States)

    Manunta, Michele; Casu, Francesco; Zinno, Ivana; De Luca, Claudio; Pacini, Fabrizio; Caumont, Hervé; Brito, Fabrice; Blanco, Pablo; Iglesias, Ruben; López, Álex; Briole, Pierre; Musacchio, Massimo; Buongiorno, Fabrizia; Stumpf, Andre; Malet, Jean-Philippe; Brcic, Ramon; Rodriguez Gonzalez, Fernando; Elias, Panagiotis

    2017-04-01

    The idea to create advanced platforms for the Earth Observation community, where the users can find data but also state-of-art algorithms, processing tools, computing facilities, and instruments for dissemination and sharing, has been launched several years ago. The initiatives developed in this context have been supported firstly by the Framework Programmes of European Commission and the European Space Agency (ESA) and, progressively, by the Copernicus programme. In particular, ESA created and supported the Grid Processing on Demand (G-POD) environment, where the users can access to advanced processing tools implemented in a GRID environment, satellite data and computing facilities. All these components are located in the same datacentre to significantly reduce and make negligible the time to move the satellite data from the archive. From the experience of G-POD was born the idea of ESA to have an ecosystem of Thematic Exploitation Platforms (TEP) focused on the integration of Ground Segment capabilities and ICT technologies to maximize the exploitation of EO data from past and future missions. A TEP refers to a computing platform that deals with a set of user scenarios involving scientists, data providers and ICT developers, aggregated around an Earth Science thematic area. Among the others, the Geohazards Exploitation Platform (GEP) aims at providing on-demand and systematic processing services to address the need of the geohazards community for common information layers and to integrate newly developed processors for scientists and other expert users. Within GEP, the community benefits from a cloud-based environment, specifically designed for the advanced exploitation of EO data. A partner can bring its own tools and processing chains, but also has access in the same workspace to large satellite datasets and shared data processing tools. GEP is currently in the pre-operations phase under a consortium led by Terradue Srl and six pilot projects concerning

  16. Avaliação imediata da dor e edema em lesão muscular induzida por formalina e tratada com laser 808 nm Immediate pain and edema assessment in muscular injury induced by formalin and treated with low-level laser (808nm

    Directory of Open Access Journals (Sweden)

    Emerson Borato

    2008-10-01

    Full Text Available O laser de baixa potência induz a bioestimulação celular, podendo acelerar a cicatrização de feridas, promover a regeneração do músculo esquelético, diminuir a resposta inflamatória, estimular a neoformação de vasos sanguíneos e diminuir a dor. O objetivo deste estudo foi analisar os efeitos de três doses de laser de baixa intensidade (808nm, na dor e edema imediatos, em ratos submetidos a lesão experimental do músculo gastrocnêmio lateral. Foram utilizados 24 ratos Wistar, distribuídos aleatoriamente em quatro grupos, sendo: GC - animais lesionados e tratados com aparelho desligado (simulacro; G20 - animais lesionados e irradiados com dose de 20J/cm²; G50 - animais lesionados e irradiados com 50J/cm; e G100 - animais lesionados e irradiados com 100J/cm². Para a produção da lesão experimental, introduziu-se 0,1mL de formalina a 5% no ventre do músculo gastrocnêmio lateral direito. A avaliação da dor ocorreu através do tempo de elevação da pata (TEP e o edema foi avaliado com auxílio de paquímetro metálico; ambas as avaliações ocorreram pré-lesão, pós-lesão, pós-tratamento, duas, oito e 24 horas pós-lesão. Os resultados mostraram aumento significativo do TEP e da avaliação com paquímetro, após a indução da lesão. Conclui-se que laser nos parâmetros utilizados não produziu diminuição na dor e edema, em animais submetidos a lesão muscular com injeção de formalina a 5%.Low-level laser therapy induces to cellular bioestimulation and can accelerate wound healing, promote skeletal muscle regeneration, decrease inflammatory response, stimulate neovascularization and decrease pain. The aim of this study was to analyze the effects of three doses of low-level laser therapy (808 nm, in the immediate pain and edema, in rats submitted to experimental injury of the lateral gastrocnemius muscle. Twenty four Wistar rats, randomly distributed in the following four groups were used: CG - injured and treated

  17. Improvement of the design model for SMART fuel assembly

    International Nuclear Information System (INIS)

    Zee, Sung Kyun; Yim, Jeong Sik

    2001-04-01

    A Study on the design improvement of the TEP, BEP and Hoddown spring of a fuel assembly for SMART was performed. Cut boundary Interpolation Method was applied to get more accurate results of stress and strain distribution from the results of the coarse model calculation. The improved results were compared with that of a coarse one. The finer model predicted slightly higher stress and strain distribution than the coarse model, which meant the results of the coarse model was not converged. Considering that the test results always showed much less stress than the FEM and the location of the peak stress of the refined model, the pressure stress on the loading point seemed to contribute significantly to the stresses. Judging from the fact that the peak stress appeared only at the local area, the results of the refined model were considered enough to be a conservative prediction of the stress levels. The slot of the guide thimble screw was ignored to get how much thickness of the flow plate can be reduced in case of optimization of the thickness and also cut off the screw dent hole was included for the actual geometry. For the BEP, the leg and web were also included in the model and the results with and without the leg alignment support were compared. Finally, the holddown spring which is important during the in-reactor behavior of the FA was modeled more realistic and improved to include the effects of the friction between the leaves and the loading surface. Using this improved model, it was possible that the spring characteristics were predicted more accurate to the test results. From the analysis of the spring characteristics, the local plastic area controled the characteristics of the spring dominantly which implied that it was necessary for the design of the leaf to be optimized for the improvement of the plastic behavior of the leaf spring

  18. The Role of Tropical Cyclones in Precipitation Over the Tropical and Subtropical North America

    Directory of Open Access Journals (Sweden)

    Christian Dominguez

    2018-03-01

    Full Text Available Tropical cyclones (TCs are essential elements of the hydrological cycle in tropical and subtropical regions. In the present study, the contribution of TCs to seasonal precipitation around the tropical and subtropical North America is examined. When TC activity over the tropical eastern Pacific (TEP or the Intra Americas Seas (IAS is below (above-normal, regional precipitation may be below (above-normal. However, it is not only the number of TCs what may change seasonal precipitation, but the trajectory of the systems. TCs induce intense precipitation over continental regions if they are close enough to shorelines, for instance, if the TC center is located, on average, less than 500 km-distant from the coast. However, if TCs are more remote than this threshold distance, the chances of rain over continental regions decrease, particularly in arid and semi-arid regions. In addition, a distant TC may induce subsidence or produce moisture divergence that inhibits, at least for a few days, convective activity farther away than the threshold distance. An analysis of interannual variability in the TCs that produce precipitation over the tropical and subtropical North America shows that some regions in northern Mexico, which mostly depend on this effect to undergo wet years, may experience seasonal negative anomalies in precipitation if TCs trajectories are remote. Therefore, TCs (activity and trajectories are important modulators of climate variability on various time scales, either by producing intense rainfall or by inhibiting convection at distant regions from their trajectory. The impact of such variations on water availability in northern Mexico may be relevant, since water availability in dams recovers under the effects of TC rainfall. Seasonal precipitation forecasts or climate change scenarios for these regions should take into account the effect of TCs, if regional adaptation strategies are implemented.

  19. DETERMINATION OF THE THICKNESS OF THE COMPONENTS OF A DOUBLE-LAYER NICKEL-CHROMIUM COATING BY MAGNETIC PONDEROMOTIVE METHOD WITH UNILATERAL ACCESS TO THE CONTROLLED SURFACE

    Directory of Open Access Journals (Sweden)

    Y. V. Gnutenko

    2017-01-01

    Full Text Available The application of thick-layer nickel (up to 700 μm and chromium (up to 200 μm coatings has been widely used to give the combustion chamber of a liquid-propellant rocket engine the required operational properties. The main parameter that determines the ability of a coating to fulfill its function is its thickness and uniformity of its distribution. The main problem of current nondestructive methods for determining the thickness of coatings under consideration is that they can be used only at the stage of production of rocket engineering products, when there is an access to the product from the side of the inner wall of the combustion chamber before and after applying a chromium coating to the nickel sublayer. However, when an already finished product arrives at subsequent stages of assembly to another enterprise, there is often a need of incoming control of the thicknesses of coatings from nickel and chromium. In this case, it is not possible to apply existing control techniques to a finished product, or the use of these techniques leads to unacceptable errors in the results of measurements. The goal of the research was to develop a technique for nondestructive determination of the thickness of each component of the two-layer nickel-chromium coating by the magnetic ponderomotive method under conditions of unilateral access to the finished product from the side of the chromium coating.A new technique for nondestructive determination of the thicknesses of nickel and chromium coatings of the double-layer structure on a finished product without a priori data on the properties or thicknesses of these coatings or a product in general is proposed using a magnetic ponderomotive method.This newly developed technique is implemented in the thickness gauge TEP-XN1 of double-layer nickel- chromium coatings, which is successfully used by enterprises of the rocket and space industry of the Russian Federation.

  20. Contenu énergétique des alcools d'origine fossile ou biomasse Energy Content of Alcohols of Fossil Or Biomass Origin

    Directory of Open Access Journals (Sweden)

    Arlie J. P.

    2006-11-01

    Full Text Available En utilisant une méthode basée sur le contenu énergétique, défini comme étant la quantité d'énergie mise en oeuvre dans le processus de fabrication depuis la matière première jsuqu'au produit considéré, on compare les filières de production basées sur des matières premières soit d'origine fossile, soit d'origine biomasse. Ces filières peuvent être utilisées pour produire les divers alcools que sont le méthanol, l'éthanol et le butanol. II est montré, qu'en l'état actuel des technologies de fabrication, la comparaison énergétique est très en faveur de la filière matière première renouvelable qui fait apparaître un gain énergétique qui varie suivant les cas étudiés entre 0,1 et 1,5 tep par tonne de produit. Production routes based on raw materials from either fossil or biomass origin are compared using a method based on the energy content, which is defined as being the amount of energy implemented in the manufacturing process starting with the raw material and going to the product being considered. These routes can be used to produce different alcohols such as methanol, ethanol and butanol. Given the current state of manufacturing technologies, this article shows that an energy comparison is highly in favor of the renewable raw-material route which shows an energy gain that varies, according to the cases examined, between 0. 1 and 1. 5 tOE per ton of product.

  1. The effect of pre-straining and pre-ageing on a novel thermomechanical treatment for improving the mechanical properties of AA2139 aerospace aluminium alloys

    Science.gov (United States)

    Bakare, F.; Alsubhi, Y.; Ragkousis, A.; Ebomwonyi, O.; Damisa, J.; Okunzuwa, S.

    2017-07-01

    The novel thermomechanical treatment employed by Wang Z et al (2014 Mater. Sci. Eng. A 607 313-7) in enhancing the mechanical and microstructure properties of 6000 series aluminium alloys has been replicated for AA2139 aerospace aluminium alloys. The novel route which involves under-ageing, cold-rolling reductions and re-ageing at a fixed temperature has been carried out focusing on the effect of pre-straining and pre-ageing on the alloy properties. The influence of varying cold-rolling reductions and pre-ageing has been examined by tensile testing, hardness testing, differential scanning calorimetry, thermoelectric power measurements and scanning electron microscope (SEM). Further analyses were conducted with DSC and TEP measurements to check for precipitation sequence and solute retention respectively. On comparing the hardness and strength of the non pre-aged to the pre-aged samples, there is a remarkable increase in the hardness and strength of the aerospace alloy showing the huge influence of both pre-ageing and pre-straining stage of the novel thermomechanical treatment as observed in the 6000 series alloy, albeit at a higher rate. The treatments that exhibited the most promising mechanical properties (hardness, yield and ultimate tensile strength, elongation to failure) were found to be at a pre-ageing temperature of 175 °C for 1.5 h, 40% cold-rolling and re-ageing at 150 °C. The material was found to have yield strength of 590 MPa and 8.1% uniform elongation, which is well above the 5% acceptable value for structural applications and with strength levels adaptable for aerospace industries. The presence of higher volume fraction of well dispersed precipitates observed in the SEM further shows that intermediate cold-rolling reductions combines well with pre-ageing to give the best mechanical properties in this alloy.

  2. Linking heterotrophic microbial activities with particle characteristics in waters of the Mississippi River Delta in the aftermath of Hurricane Isaac

    Directory of Open Access Journals (Sweden)

    Kai eZiervogel

    2016-02-01

    Full Text Available Riverine runoff often triggers microbial responses in coastal marine environments, including phytoplankton blooms and enhanced bacterial biomass production that drive the transformation of dissolved and particulate organic matter on its way from land to the deep ocean. We measured concentrations and characteristics of particulate organic matter (POM, concentrations of dissolved organic carbon (DOC, and bacterial community abundance and activities in the water column at three sites near the Mississippi River Delta two weeks after Hurricane Isaac made landfall in late August 2012. River plumes had salinities of >30 PSU and high levels of DOC (210-380 µM, resulting from the storm surge that pushed large quantities of marine waters upstream. Relatively high concentrations of phytoplankton POM and low levels of microbial exopolymeric particles (TEP and CSP suggested that storm-induced riverine discharge triggered the development of phytoplankton blooms that were in their initial stages at the time of sampling. Surface water POM had C/N ratios of 5-7 and strong protein-like fluorescence signals in the base-extracted POM (BEPOM fraction at the two sites closer to the river mouth (Stns. TE and MSP. Freshly produced POM triggered a twofold increase in heterotrophic bacterial biomass production (3H-leucine incorporation and a fourfold increase in bacterial peptide hydrolysis (activities of leucine-aminopeptidase. In contrast, elevated DOC concentrations coincided with only moderate bacterial community activity, suggesting that heterotrophic bacterial metabolism near the Mississippi River Delta in the aftermath of Hurricane Isaac was more closely linked with autochthonous primary production.

  3. Final technology report for D-Area oil seepage basin bioventing optimization test, environmental restoration support

    International Nuclear Information System (INIS)

    Radway, J.C.; Lombard, K.H.; Hazen, T.C.

    1997-01-01

    One method proposed for the cleanup of the D-Area Oil Seepage Basin was in situ bioremediation (bioventing), involving the introduction of air and gaseous nutrients to stimulate contaminant degradation by naturally occurring microorganisms. To test the feasibility of this approach, a bioventing system was installed at the site for use in optimization testing by the Environmental Biotechnology Section of the Savannah River Technology Center. During the interim action, two horizontal wells for a bioventing remediation system were installed eight feet below average basin grade. Nine piezometers were also installed. In September of 1996, a generator, regenerative blower, gas cylinder station, and associated piping and nutrient injection equipment were installed at the site and testing was begun. After baseline characterization of microbial activity and contaminant degradation at the site was completed, four injection campaigns were carried out. These consisted of (1) air alone, (2) air plus triethylphosphate (TEP), (3) air plus nitrous oxide, and (4) air plus methane. This report describes results of these tests, together with conclusions and recommendations for further remediation of the site. Natural biodegradation rates are high. Oxygen, carbon dioxide, and methane levels in soil gas indicate substantial levels of baseline microbial activity. Oxygen is used by indigenous microbes for biodegradation of organics via respiration and hence is depleted in the soil gas and water from areas with high contamination. Carbon dioxide is elevated in contaminated areas. High concentrations of methane, which is produced by microbes via fermentation once the oxygen has been depleted, are found at the most contaminated areas of this site. Groundwater measurements also indicated that substantial levels of natural contaminant biodegradation occurred prior to air injection

  4. Professional practice assessment. Pertinence of positron emission tomography clinical indications in oncology; Evaluation des pratiques professionnelles. Pertinence des indications de la tomographie a emission de positons en cancerologie

    Energy Technology Data Exchange (ETDEWEB)

    Le Stanc, E.; Tainturier, C. [Hopital Foch, Service de Medecine Nucleaire, 92 - Suresnes (France); Swaenepoel, J. [Hopital Foch, Cellule Qualite, 92 - Suresnes (France)

    2009-09-15

    Introduction As part of the health care quality and safety policy in France, Professional Practice Assessment (P.P.A.) are mandatory in the health services 'certification' process. We present our study regarding the pertinence of Positron Emission Tomography (PET) indications in oncology. Materials and methods A multidisciplinary task group used the Quick Audit method with two rounds of 100 request forms each. The assessment list of criteria comprised four items of decreasing relevance grading the PET scans clinical indications, which were derived from the three French published guidelines (S.O.R. [F.N.C.L.C.C]., 'Guide du bon usage des examens d'imagerie medicale' [S.F.R.-S.F.M.N.], 'Guide pour la redaction de protocoles pour la TEP au F.D.G. en cancerologie' [S.F.M.N.]) and five additional items: clinical information, patient's body weight, previous treatments dates, diabetes, claustrophobia. Results The first round showed that 68% of the requested scans corresponded to the two most relevant groups of indications (S.O.R. Standards and Options). The request forms were correctly filled in regarding the clinical information, but this was not the case for the other items we tested. Several actions were conducted: dedicated PET request form, availability of the S.O.R. on the hospital intranet, boost of the referring physicians awareness during the multidisciplinary oncology meetings (Reunions de Concertation Pluridisciplinaires RCP). The second round showed a better pertinence of the PET scans indications (75% versus 68%); the patient's body weight was more frequently mentioned on the request form. Discussion This study is an example of P.P.A. in our discipline. It led to an improvement of the oncologic PET scans clinical indications in our hospital. This work is pursued in everyday discussion with the referring clinicians, especially during the RCP. (authors)

  5. Assessment of voice related quality of life and its correlation with socioeconomic status after total laryngectomy.

    Science.gov (United States)

    Agarwal, Sangeet Kumar; Gogia, Shweta; Agarwal, Alok; Agarwal, Rajiv; Mathur, Ajay Swaroop

    2015-10-01

    After total laryngectomy for laryngeal cancer, the major determinants of QOL is the patient's voice related quality of life (V-RQOL). The primary aim of this study was to assess the V-RQOL and impact of socioeconomic status over it in Indian population by using two validated scales [voice handicap index (VHI) and V-RQOL questionnaires]. Total 104 patients underwent total laryngectomy but 71 were eligible for study. Patients filled the VHI and V-RQOL questionnaires after completion of 1 year of usage of the TEP voice. The socioeconomic status of the patients was calculated according to various domains related to their life and were divided into lower and higher status. A total of 76.1% patients had VHI score between 0 to 30 (minimal voice handicap), 19.7% had score between 31 to 60 (moderate voice handicap) and only 4.2% patients had VHI score more than 61 (serious voice handicap). On V-RQOL scores, 16.9% patients had score between 10 to 15 (excellent), 40.8% patients, between 16 to 20 (very good), 22.5% patients, between 21 and 25 (good voice), 15.5% patients, between 26 and 30 (fair) and only 4.2% patients scored more than 30 with poor quality of voice. Patients with lower socioeconomic group had better V-RQOL than with high socioeconomic group. VHI and V-RQOL scores in our series were superior to other studies due to major population with lower socioeconomic status and better social support which exists in our society.

  6. Hygiene and didactic criteria of adaptation to the initial stage of training in higher education establishments

    Directory of Open Access Journals (Sweden)

    Grebnyak N.P.

    2017-06-01

    Full Text Available Reform of higher education in the conditions of deep social and economic transformations determines both optimization of professional training and development of functional capacity of the organism for future work. The initial stage of training is of particular importance due to incorporation into a complex new system of educational environment. The aim of the work - to study the characteristics of adaptation process in the first-year students. Functional state of students’ organism was studied by visual-motor response, function of attention, speed, of information processing, tepping-test. This cross-sectional study included 179 first-year medical students. Students with a history of hearing or visual disorder, smoking, alcoholism, cardiovascular and respiratory disease and on medication which affects cognitive performance were excluded from the study. Participation in the test was voluntary and informed written consent was taken from each participant. Academic performance was analyzed. Pearson correlation has been used to find the significance of relationship between the speed of thought processes, function of attention, factor of motometria, volume of visual memory and academic performance. Adaptation of students to training is based on the functional system of the body. Expressed correlation between the speed of thought processes (r=0,63, р<0,01, function of attention (r=0,47, р<0,05, ratio of motometry (r=0,45, р<0,05, volume of visual memory (r=0,43, р<0,05 and academic performance was established. The distribution of these indicators demonstrates the feasibility of using Standard deviation to assess the degree of adaptation.

  7. Matrix molecularly imprinted mesoporous sol-gel sorbent for efficient solid-phase extraction of chloramphenicol from milk.

    Science.gov (United States)

    Samanidou, Victoria; Kehagia, Maria; Kabir, Abuzar; Furton, Kenneth G

    2016-03-31

    Highly selective and efficient chloramphenicol imprinted sol-gel silica based inorganic polymeric sorbent (sol-gel MIP) was synthesized via matrix imprinting approach for the extraction of chloramphenicol in milk. Chloramphenicol was used as the template molecule, 3-aminopropyltriethoxysilane (3-APTES) and triethoxyphenylsilane (TEPS) as the functional precursors, tetramethyl orthosilicate (TMOS) as the cross-linker, isopropanol as the solvent/porogen, and HCl as the sol-gel catalyst. Non-imprinted sol-gel polymer (sol-gel NIP) was synthesized under identical conditions in absence of template molecules for comparison purpose. Both synthesized materials were characterized by Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FT-IR) and nitrogen adsorption porosimetry, which unambiguously confirmed their significant structural and morphological differences. The synthesized MIP and NIP materials were evaluated as sorbents for molecularly imprinted solid phase extraction (MISPE) of chloramphenicol in milk. The effect of critical extraction parameters (flow rate, elution solvent, sample and eluent volume, selectivity coefficient, retention capacity) was studied in terms of retention and desorption of chloramphenicol. Competition and cross reactivity tests have proved that sol-gel MIP sorbent possesses significantly higher specific retention and enrichment capacity for chloramphenicol compared to its non-imprinted analogue. The maximum imprinting factor (IF) was found as 9.7, whereas the highest adsorption capacity of chloramphenicol by sol-gel MIP was 23 mg/g. The sol-gel MIP was found to be adequately selective towards chloramphenicol to provide the necessary minimum required performance limit (MRPL) of 0.3 μg/kg set forth by European Commission after analysis by LC-MS even without requiring time consuming solvent evaporation and sample reconstitution step, often considered as an integral part in solid phase extraction work-flow. Intra and

  8. Comparative study of nano copper aluminate spinel prepared by sol–gel and modified sol–gel techniques: Structural, electrical, optical and catalytic studies

    International Nuclear Information System (INIS)

    Kumar, R. Thinesh; Suresh, P.; Selvam, N. Clament Sagaya; Kennedy, L. John; Vijaya, J. Judith

    2012-01-01

    Highlights: ► A modified sol–gel method for the preparation of nano CuAl 2 O 4 spinel using ethylenediamine was studied. ► Role of ethylenediamine in enhancing the structural, electrical, optical and catalytic properties of copper aluminate is highlighted. ► Effect of preparation method on the activity and selectivity of the samples on the oxidation of benzyl alcohol by CuAl 2 O 4 is studied. - Abstract: The effect of ethylenediamine addition in the sol–gel method for the preparation of nano CuAl 2 O 4 spinel for the enhancement in their structural, electrical, optical and catalytic properties was investigated. The samples were prepared by two different methods: sol–gel and modified sol–gel technique using ethylenediamine. X-ray diffraction (XRD), Fourier transform infrared spectra (FT-IR), scanning electron microscopy (SEM), high resolution-transmission electron microscopy (HR-TEM), energy dispersive X-ray analysis (EDX), nitrogen adsorption/desorption isotherms, temperature dependent conductance measurements, thermoelectric power (TEP) measurements and UV–visible diffuse reflectance (UV–vis-DRS) spectra were used to characterize the samples prepared. CuAl 2 O 4 prepared by modified sol–gel technique was found to possess a higher surface area, lower crystallite size, lower activation energy and high porosity than the one prepared by sol–gel method which in turn lead to the improved performance of it towards the selective oxidation of benzyl alcohol to benzaldehyde. Effect of solvent on the catalytic oxidation of benzyl alcohol by the nano CuAl 2 O 4 prepared by modified sol–gel technique was also investigated.

  9. The twin faces of pleasure: The relationship between pleasure and compassion fatigue

    Directory of Open Access Journals (Sweden)

    2015-09-01

    Full Text Available Aims: Compassion Fatigue (CF can be pervasive and debilitating for individuals in some professions. For organisations, it can result in substantial costs in terms of staff productivity and retention. Activities found to be pleasurable - termed hedonic - may play a protective role during times of stress. However, hedonic activities can also be used in ways that are risky and maladaptive. Two theories were tested in the current study: firstly, that hedonic pleasure is used adaptively to counteract factors that may lead to CF; and secondly, that hedonic pursuits are used maladaptively and thus represent risk factors for CF. Method: 176 adults (74% female completed a suite of questionnaires presented online. Two self-report scales assessed the individual's behaviour related to pleasurable activities. The TEPS captured behaviour of an adaptive nature, while the ‘shorter PROMIS’ measured maladaptive uses of pleasure. Compassion Fatigue was assessed with a sub-scale of the Professional Quality of Life scale (ProQOL. Results: The measures of pleasure activities were not significantly correlated. A small, significant negative correlation was found between CF and the adaptive model (r(176 = -.19, p < .009. There was also a positive correlation between CF and maladaptive use of pleasure (r(176 = .21, p = .006 but both associations were weak in this sample. Conclusions: The measures of hedonic activities appear to estimate separate constructs. Both faces of hedonic pleasure were slightly correlated with reported Compassion Fatigue: adaptive pleasure was associated with lower scores while maladaptive pleasure tended to be linked to higher scores. However, experimental work is needed to establish the direction of these effects as general fatigue or workload may be affecting the frequency and quality of pleasure seeking.

  10. COMET-LICSAR: Systematic Deformation Monitoring of Fault Zones and Volcanoes with the Sentinel-1 Constellation

    Science.gov (United States)

    Spaans, K.; Wright, T. J.; Hooper, A. J.; Hatton, E. L.; González, P. J.; Bhattarai, S.; Biggs, J.; Crippa, P.; Ebmeier, S. K.; Elliott, J.; Gaddes, M.; Li, Z.; Parsons, B.; Qiu, Q.; McDougall, A.; Walters, R. J.; Weiss, J. R.; Ziebart, M.

    2017-12-01

    The Sentinel-1 constellation represents a major advance in our ability to monitor our planet's hazardous tectonic and volcanic zones. Here we present the latest progress from COMET (*), where we are now providing deformation results to the community for volcanoes and the tectonic belts (**). COMET now responds routinely to most significant continental earthquakes - Sentinel-1 allows us to do this within a few days for most earthquakes. For example, after the M7.8 Kaikoura (New Zealand) earthquake we supplied a processed interferogram to the community just 5 hours and 37 minutes after the Sentinel-1 acquisition. By the end of 2017, we will be producing interferogram products systematically for all earthquakes larger than M 6.0. For deformation data to be useful for preparedness, we need accuracy on the order of 1 mm/yr or better. This requires mass processing of long time series of radar acquisitions. We are currently (July 2017) processing interferograms systematically for the entire Alpine-Himalayan belt ( 9000 x 2000 km) using our LiCSAR chain, making interferograms and coherence products available to the community. By December 2017, we plan to process a wider tectonic area and the majority of subaerial volcanoes. We currently serve displacement and coherence grids, but plan to provide average deformation rates and time series. Results are available through our dedicated portal (**), and are being linked to the ESA G-TEP and EPOS during 2017. We will show the latest results for tectonics and volcanism, and discuss how these can be used to build value-added products, including (i) maps of tectonic strain (ii) maps of seismic hazard (iii) volcano deformation alerts. The accuracy of these products will improve as the number of data products acquired by Sentinel-1 increases, and as the time series lengthen. *http://comet.nerc.ac.uk**http://comet.nerc.ac.uk/COMET-LiCS-portal/

  11. Evolución de los niveles de burnout en un estudio comparativo en cuidadores profesionales tras una situación de estrés postraumático

    Directory of Open Access Journals (Sweden)

    Juan P. Martínez

    2012-04-01

    Full Text Available Tras un estudio previo realizado en cuidadores profesionales de personas con demencia y otras enfermedades en centros residenciales en el que se comparó dos muestras en distintas comunidades autónomas, Murcia y Barcelona. Partiendo de los resultados obtenidos en los cuales el 13.3% de la muestra global presentaba un agotamiento emocional alto, un 54.8% un nivel de despersonalización alto y un 10% una baja realización personal, se procede a realizar un análisis de los niveles actuales en las tres dimensiones para estudiar su evolución. Del mismo modo, se evalúa si en la población de Lorca (Murcia dichos niveles han podido verse afectados por el terremoto acaecido el 11 de mayo de 2011, para lo cual se ha llevado a cabo una evaluación de posibles síntomas de un Trastorno por Estrés Postraumático (TEP. Se ha procedido a la administración de las mismas pruebas de la última investigación (escala Maslach Burnout Inventory -MBI- y Encuesta elaborada ad hoc para Cuidadores Profesionales junto a la escala SA-45 forma abreviada de la SCL-90 y la Escala de Gravedad de Síntomas del Trastorno de Estrés Postraumático. Los resultados obtenidos reflejan diferencias entre ambas poblaciones en diversas variables analizadas y arrojan luz acerca de las consecuencias y el impacto de una situación traumática en la población. Palabras clave: Burnout, estrés postraumático, cuidadores, demencias y estudio comparativo.

  12. Thermoelectric assessment of laser peening induced effects on a metallic biomaterial Ti6Al4V

    Science.gov (United States)

    Carreón, H.; Barriuso, S.; Porro, J. A.; González-Carrasco, J. L.; Ocaña, J. L.

    2014-03-01

    Laser peening has recently emerged as a useful technique to overcome detrimental effects associated to another wellknown surface modification processes such as shot peening or grit blasting used in the biomedical field. It is worth to notice that besides the primary residual stress effect, thermally induced effects might also cause subtle surface and subsurface microstructural changes that might influence corrosion resistance. Moreover, since maximum loads use to occur at the surface, they could also play a critical role in the fatigue strength. In this work, plates of Ti-6Al-4V alloy of 7 mm in thickness were modified by laser peening without using a sacrificial outer layer. Irradiation by a Q-switched Nd-YAG laser (9.4 ns pulse length) working in fundamental harmonic at 2.8 J/pulse and with water as confining medium was used. Laser pulses with a 1.5 mm diameter at an equivalent overlapping density (EOD) of 5000 cm-2 were applied. Attempts to analyze the global induced effects after laser peening were addressed by using the contacting and non-contacting thermoelectric power (TEP) techniques. It was demonstrated that the thermoelectric method is entirely insensitive to surface topography while it is uniquely sensitive to subtle variations in thermoelectric properties, which are associated with the different material effects induced by different surface modification treatments. These results indicate that the stress-dependence of the thermoelectric power in metals produces sufficient contrast to detect and quantitatively characterize regions under compressive residual stress based on their thermoelectric power contrast with respect to the surrounding intact material. However, further research is needed to better separate residual stress effects from secondary material effects, especially in the case of low-conductivity engineering materials like titanium alloys.

  13. Impact of migraine on fibromyalgia symptoms.

    Science.gov (United States)

    Giamberardino, Maria Adele; Affaitati, Giannapia; Martelletti, Paolo; Tana, Claudio; Negro, Andrea; Lapenna, Domenico; Curto, Martina; Schiavone, Cosima; Stellin, Luisa; Cipollone, Francesco; Costantini, Raffaele

    2015-01-01

    Fibromyalgia (FMS) and high frequency episodic/chronic migraine (M) very frequently co-occur, suggesting common pathophysiological mechanisms; both conditions display generalized somatic hyperalgesia. In FMS-M comorbidity we assessed if: a different level of hyperalgesia is present compared to one condition only; hyperalgesia is a function of migraine frequency; migraine attacks trigger FMS symptoms. Female patients with fibromyalgia (FMS)(n.40), high frequency episodic migraine (M1)(n.41), chronic migraine (M2)(n.40), FMS + M1 (n.42) and FMS + M2 (n.40) underwent recording of: -electrical pain thresholds in skin, subcutis and muscle and pressure pain thresholds in control sites, -pressure pain thresholds in tender points (TePs), -number of monthly migraine attacks and fibromyalgia flares (3-month diary). Migraine and FMS parameters were evaluated before and after migraine prophylaxis, or no prophylaxis, for 3 months with calcium-channel blockers, in two further FMS + H1 groups (n.49, n.39). 1-way ANOVA was applied to test trends among groups, Student's t-test for paired samples was used to compare pre and post-treatment values. The lowest electrical and pressure thresholds at all sites and tissues were found in FMS + M2, followed by FMS + H1, FMS, M2 and M1 (trend: p fibromyalgia and migraine involves heightened somatic hyperalgesia compared to one condition only. Increased migraine frequency - with shift towards chronicity - enhances both hyperalgesia and spontaneous FMS pain, which is reversed by effective migraine prophylaxis. These results suggest different levels of central sensitization in patients with migraine, fibromyalgia or both conditions and a role for migraine as a triggering factor for FMS.

  14. Effect of acetic acid complex on physical properties of nanostructured spray deposited FeCdS{sub 3} thin films

    Energy Technology Data Exchange (ETDEWEB)

    Ubale, A.U., E-mail: ashokuu@yahoo.com [Thin Film Physics Laboratory, Department of Physics, Govt. Vidarbha Institute of Science and Humanities, VMV Road, Amravati 444604, Maharashtra (India); Ibrahim, S.G. [Thin Film Physics Laboratory, Department of Physics, Govt. Vidarbha Institute of Science and Humanities, VMV Road, Amravati 444604, Maharashtra (India)

    2011-02-03

    Research highlights: > Nanostructured FeCdS{sub 3} thin films were prepared onto glass substrate by spray pyrolysis method. > The acetic acid complex used in deposition process affects the structural, electrical and optical properties of FeCdS{sub 3} thin films. > The films deposited at lower concentration of acetic acid are nanocrystalline and becomes amorphous above 0.15 M concentration of acetic acid. - Abstract: Spray pyrolysis method which is simple as well as economic was used for the preparation of ternary nanostructured FeCdS{sub 3} thin films onto glass substrates from ferric nitrate and cadmium chloride as Cd and Fe source and acetic acid as a complexing agent. The prepared films were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and optical absorption techniques. The structural, electrical, optical and morphological properties of FeCdS{sub 3} thin films were influenced by quantity of acetic acid in spray solution. The X-ray spectrum and SEM reveal that the FeCdS{sub 3} shows transition from nanocrystalline to amorphous phase depending on concentration of acetic acid. Optical band-gap of the amorphous and nanocrystalline film is found 2.40 and 2.65 eV, respectively. Nanocrystalline films have dark resistivity of the order of 10{sup 3} {Omega} cm whereas amorphous films have 10{sup 4} {Omega} cm. Thermoelectric power (TEP) measurement studies reveal that the films have p-type conductivity. It also shows that amorphous film generates less thermo-emf as compared to nanocrystalline film.

  15. Dynamics of immune system gene expression upon bacterial challenge and wounding in a social insect (Bombus terrestris.

    Directory of Open Access Journals (Sweden)

    Silvio Erler

    2011-03-01

    Full Text Available The innate immune system which helps individuals to combat pathogens comprises a set of genes representing four immune system pathways (Toll, Imd, JNK and JAK/STAT. There is a lack of immune genes in social insects (e.g. honeybees when compared to Diptera. Potentially, this might be compensated by an advanced system of social immunity (synergistic action of several individuals. The bumble bee, Bombus terrestris, is a primitively eusocial species with an annual life cycle and colonies headed by a single queen. We used this key pollinator to study the temporal dynamics of immune system gene expression in response to wounding and bacterial challenge.Antimicrobial peptides (AMP (abaecin, defensin 1, hymenoptaecin were strongly up-regulated by wounding and bacterial challenge, the latter showing a higher impact on the gene expression level. Sterile wounding down-regulated TEP A, an effector gene of the JAK/STAT pathway, and bacterial infection influenced genes of the Imd (relish and JNK pathway (basket. Relish was up-regulated within the first hour after bacterial challenge, but decreased strongly afterwards. AMP expression following wounding and bacterial challenge correlates with the expression pattern of relish whereas correlated expression with dorsal was absent. Although expression of AMPs was high, continuous bacterial growth was observed throughout the experiment.Here we demonstrate for the first time the temporal dynamics of immune system gene expression in a social insect. Wounding and bacterial challenge affected the innate immune system significantly. Induction of AMP expression due to wounding might comprise a pre-adaptation to accompanying bacterial infections. Compared with solitary species this social insect exhibits reduced immune system efficiency, as bacterial growth could not be inhibited. A negative feedback loop regulating the Imd-pathway is suggested. AMPs, the end product of the Imd-pathway, inhibited the up-regulation of the

  16. Axes of Discovery: The Time Domain and the Radio Synoptic Survey Telescope

    Science.gov (United States)

    Cordes, J. M.

    2008-08-01

    As Heraclitus might have said, ``You don't observe the same universe twice,'' and in modern times we recognize the time domain as an important dimension in the overall phase space of variables that characterizes the observable universe. Examples abound across the electromagnetic spectrum and in non-photonic regimes (neutrinos, gravitational waves, cosmic rays). However, while we can glimpse the richness of time-domain phenomena at radio wavelengths, the radio sky is largely unexplored in any comprehensive sense, especially when compared to the successes of wide-field surveys at high energies. Known radio transients are as short as 0.4 ns with an equivalent brightness temperature of 1042 K tep{jmc:he07} related to the coherent nature of pulsar radiation; others with incoherent emission extend to hour and longer time scales with thermal brightness temperatures. Some time-domain properties are intrinsic to sources while others are imposed by multi-path propagation through intervening plasma. This paper discusses both known and speculative aspects of the radio transient sky, with an emphasis on discoveries that can be made with new, appropriately designed instrumentation and telescopes. A generalized survey figure of merit is presented that takes into account the rate and duration of transient celestial events. The key for expanding discovery space is a wide field of view (FoV) combined with adequate sensitivity and high-resolution sampling in time and frequency. I discuss implementation of time-domain studies as an integral part of synoptic survey modes and the potential for cross-wavelength and joint photonic/non-photonic studies. In particular, I make the case for designing and operating the mid-frequency-range Square Kilometer Array as a Radio Synoptic Survey Telescope.

  17. Kinetics of niobium carbide precipitation in ferrite

    International Nuclear Information System (INIS)

    Gendt, D.

    2001-01-01

    The aim of this study is to develop a NbC precipitation modelling in ferrite. This theoretical study is motivated by the fact it considers a ternary system and focus on the concurrence of two different diffusion mechanisms. An experimental study with TEP, SANS and Vickers micro-hardening measurements allows a description of the NbC precipitation kinetics. The mean radius of the precipitates is characterized by TEM observations. To focus on the nucleation stage, we use the Tomographic Atom Probe that analyses, at an atomistic scale, the position of the solute atoms in the matrix. A first model based on the classical nucleation theory and the diffusion-limited growth describes the precipitation of spherical precipitates. To solve the set of equations, we use a numerical algorithm that furnishes an evaluation of the precipitated fraction, the mean radius and the whole size distribution of the particles. The parameters that are the interface energy, the solubility product and the diffusion coefficients are fitted with the data available in the literature and our experimental results. It allows a satisfactory agreement as regards to the simplicity of the model. Monte Carlo simulations are used to describe the evolution of a ternary alloy Fe-Nb-C on a cubic centred rigid lattice with vacancy and interstitial mechanisms. This is realized with an atomistic description of the atoms jumps and their related frequencies. The model parameters are fitted with phase diagrams and diffusion coefficients. For the sake of simplicity, we consider that the precipitation of NbC is totally coherent and we neglect any elastic strain effect. We can observe different kinetic paths: for low supersaturations, we find an expected precipitation of NbC but for higher supersaturations, the very fast diffusivity of carbon atoms conducts to the nucleation of iron carbide particles. We establish that the occurrence of this second phenomenon depends on the vacancy arrival kinetics and can be related

  18. Kinetics of niobium carbide precipitation in ferrite; Cinetiques de precipitation du carbure de niobium dans la ferrite

    Energy Technology Data Exchange (ETDEWEB)

    Gendt, D

    2001-07-01

    The aim of this study is to develop a NbC precipitation modelling in ferrite. This theoretical study is motivated by the fact it considers a ternary system and focus on the concurrence of two different diffusion mechanisms. An experimental study with TEP, SANS and Vickers micro-hardening measurements allows a description of the NbC precipitation kinetics. The mean radius of the precipitates is characterized by TEM observations. To focus on the nucleation stage, we use the Tomographic Atom Probe that analyses, at an atomistic scale, the position of the solute atoms in the matrix. A first model based on the classical nucleation theory and the diffusion-limited growth describes the precipitation of spherical precipitates. To solve the set of equations, we use a numerical algorithm that furnishes an evaluation of the precipitated fraction, the mean radius and the whole size distribution of the particles. The parameters that are the interface energy, the solubility product and the diffusion coefficients are fitted with the data available in the literature and our experimental results. It allows a satisfactory agreement as regards to the simplicity of the model. Monte Carlo simulations are used to describe the evolution of a ternary alloy Fe-Nb-C on a cubic centred rigid lattice with vacancy and interstitial mechanisms. This is realized with an atomistic description of the atoms jumps and their related frequencies. The model parameters are fitted with phase diagrams and diffusion coefficients. For the sake of simplicity, we consider that the precipitation of NbC is totally coherent and we neglect any elastic strain effect. We can observe different kinetic paths: for low supersaturations, we find an expected precipitation of NbC but for higher supersaturations, the very fast diffusivity of carbon atoms conducts to the nucleation of iron carbide particles. We establish that the occurrence of this second phenomenon depends on the vacancy arrival kinetics and can be related

  19. EFECTO DE LA INCLUSIÓN DE DIFERENTES FUENTES DE LÍPIDOS SOBRE PARÁMETROS PRODUCTIVOS Y OMPOSICIÓN PROXIMAL DEL FILETE DE TILAPIA NILÓTICA –Oreochromis niloticus– CULTIVADA EN JAULAS FLOTANTES

    Directory of Open Access Journals (Sweden)

    J. M. Moreno

    2013-01-01

    Full Text Available Para evaluar el efecto de la inclusión de diferentes fuentes de lípidos sobre el com - portamiento productivo y la composición proximal del filete de tilapia nilótica Oreo- chromis niloticus , se formularon cuatro dietas con aceite de pescado (AP, aceite de palma (APL, semilla de chía (SC o semilla de lino (SL. El experimento fue realizado durante 45 días en la represa de Betania (Huila, Colombia, en 20 jaulas flotantes, cada una con 504 peces con peso promedio de 557±16,87 g, distribuidos bajo un diseño experimental completamente al azar. Adicionalmente se llevó a cabo un estudio de presupuestos parciales, con el fin de verificar el margen bruto de ingreso parcial (MBIP obtenido con las diferentes dietas. Se observaron diferencias significativas (P < 0,05 en el factor de conversión alimenticia (FCA entre AP (1,19 y SL (1,54 y en la tasa de eficiencia proteica (TEP para AP (3,64 al comparar con las demás dietas. Por su parte, la dieta que contenía SC generó el menor MBIP, seguido de SL, APL y AP. En la composición proximal de los filetes, únicamente se observaron diferencias significativas (P < 0,05 en el contenido de proteína cruda entre AP (18,23% al compararlo con SL (19,17%. En conclusión, es posible utilizar AP, APL, SC o SL como fuentes de lípidos en las dietas, sin afectar la sobrevivencia, biomasa final, ga - nancia diaria de peso, consumo aparente de alimento, tasa específica de crecimiento e índice viscerosomático.

  20. Diagnosis and management of Spigelian hernia: A review of literature and our experience

    Directory of Open Access Journals (Sweden)

    Mittal T

    2008-01-01

    Full Text Available Spigelian hernia occurs through slit like defect in the anterior abdominal wall adjacent to the semilunar line. Most of spigelian hernias occur in the lower abdomen where the posterior sheath is deficient. The hernia ring is a well-defined defect in the transverses aponeurosis. The hernial sac, surrounded by extraperitoneal fatty tissue, is often interparietal passing through the transversus and the internal oblique aponeuroses and then spreading out beneath the intact aponeurosis of the external oblique. Spigelian hernia is in itself very rare and more over it is difficult to diagnose clinically. It has been estimated that it constitutes 0.12% of abdominal wall hernias. The spigelian hernia has been repaired by both conventional and laparoscopic approach. Laparoscopic management of spigelian hernia is well established. Most of the authors have managed it by transperitoneal approach either by placing the mesh in intraperitoneal position or by raising the peritoneal flap and placing the mesh in extraperitoneal space. There have also been case reports of management of spigelian hernia by total extraperitoneal approach. We retrospectively reviewed our experience of ten patients between 1997 and 2007. Eight patients (8/10 presented with abdominal pain and two patients (2/10 were asymptomatic. In six patients (6/10 we performed an intraperitoneal onlay IPOM repair, in two patients (2/10 transabdominal preperitoneal repair (TAPP, and in two (2/10 total extraperitoneal repair (TEP. There were no recurrences, or other morbidity at mean follow up period of 3.2 years (range 6 months to 10 years.