Anti-ceramide antibody prevents the radiation gastrointestinal syndrome in mice

Science.gov (United States)

Rotolo, Jimmy; Stancevic, Branka; Zhang, Jianjun; Hua, Guoqiang; Fuller, John; Yin, Xianglei; Haimovitz-Friedman, Adriana; Kim, Kisu; Qian, Ming; Cardó-Vila, Marina; Fuks, Zvi; Pasqualini, Renata; Arap, Wadih; Kolesnick, Richard

2012-01-01

Radiation gastrointestinal (GI) syndrome is a major lethal toxicity that may occur after a radiation/nuclear incident. Currently, there are no prophylactic countermeasures against radiation GI syndrome lethality for first responders, military personnel, or remediation workers entering a contaminated area. The pathophysiology of this syndrome requires depletion of stem cell clonogens (SCCs) within the crypts of Lieberkühn, which are a subset of cells necessary for postinjury regeneration of gut epithelium. Recent evidence indicates that SCC depletion is not exclusively a result of DNA damage but is critically coupled to ceramide-induced endothelial cell apoptosis within the mucosal microvascular network. Here we show that ceramide generated on the surface of endothelium coalesces to form ceramide-rich platforms that transmit an apoptotic signal. Moreover, we report the generation of 2A2, an anti-ceramide monoclonal antibody that binds to ceramide to prevent platform formation on the surface of irradiated endothelial cells of the murine GI tract. Consequently, we found that 2A2 protected against endothelial apoptosis in the small intestinal lamina propria and facilitated recovery of crypt SCCs, preventing the death of mice from radiation GI syndrome after high radiation doses. As such, we suggest that 2A2 represents a prototype of a new class of anti-ceramide therapeutics and an effective countermeasure against radiation GI syndrome mortality. PMID:22466649

Outcome of radiation therapy for patients with Kasabach-Merritt syndrome

International Nuclear Information System (INIS)

Mitsuhashi, Norio; Furuta, Masaya; Sakurai, Hideyuki; Takahashi, Takeo; Kato, Shingo; Nozaki, Miwako; Saito, Yoshihiro; Hayakawa, Kazushige; Niibe, Hideo

1997-01-01

Purpose: The efficacy of radiation therapy for Kasabach-Merritt syndrome, which is characterized by a huge hemangioma with consumption coagulopathy, remains controversial. In this study, we retrospectively investigated the treatment outcome of radiation therapy for seven neonates with Kasabach-Merritt syndrome. Methods and Materials: During the past 25 years we have seen seven children with Kasabach-Merritt syndrome who were treated with radiation therapy. Their ages ranged from 1 day to 5 months, with a median age of 1 month. The hemangioma was located in the extremities in four of seven children. Tumor sizes ranged from 70 cm to more than 150 cm in greatest diameter. Initial platelet counts were all less than 40,000/mm 3 except for one patient. In principle, the total dose applied to the hemangioma was 8-10 Gy, with a daily dose of 1 Gy five times a week. Results: Four of seven hemangiomas responded dramatically, with a concomitant rise of the platelet count to radiation therapy. Although the remaining three hemangiomas, all of which were ill circumscribed by widespread overlying shiny, dusky purple skin, became less tense during radiation therapy. Disseminated intravascular coagulopathy was not improved, but they have responded favorably to two or three courses of radiation therapy with an extended radiation field by 1.5 years of age. As a result, all seven patients are now surviving with no evidence of hemangioma or hematological abnormalities. Shortening of the extremity was observed in three patients who received multiple courses of radiation therapy. Conclusions: Radiation therapy appears to be one of the effective treatment options for Kasabach-Merritt syndrome despite the risk of growth delay and malignancy

Scintigraphic and Endoscopic Evaluation of Radiation-induced Acute Gastrointestinal Syndrome in Micro-pig Model

International Nuclear Information System (INIS)

Lee, Seung-Sook; Kim, Kyung-Min; Kim, Jin; Jang, Won-Suk; Lee, Jung-Eun; Kim, Noo-Ri; Lee, Sun-Joo; Kim, Mi-Sook; Ji, Young-Hoon; Cheon, Gi-Jeong; Lim, Sang-Moo

2007-01-01

Micro-pig model can be served as a proper substitute for humans in studying acute radiation syndrome following radiation-exposure accidents, especially showing similar clinico-pathologic response of hematopoietic and gastrointestinal (GI) syndrome to human. Among acute GI syndrome induced by radiation, GI motility disturbance has not been studied, however, it would be important in a viewpoint of affecting infectious progression from GI tract. Here, we employed scintigraphy of GI transit time and sequential endoscopic examination and tissue sampling in micropigs followed by abdominal radiation exposure. The specific aims of this study are to evaluate objective evidence of GI motility disturbance by scintigraphic evaluation and to find corresponding clinicoapthologic changes in radiation-induced acute GI syndrome

Radiation syndrome - pathogenesis, course, diagnostic and therapeutic measures

International Nuclear Information System (INIS)

Trott, K.R.

1981-01-01

Owing to lack of practical experience, schemes for medical aid in cases of reactor accidents are based on theoretical models and the results of radiation biology and tumor research. The chances for medical assistance are deduced from the course of the radiation syndrome in affected persons. (DG) [de

Investigation on Down's syndrome in the children living in high background radiation area

International Nuclear Information System (INIS)

Zha Yongru

1989-01-01

After the survey in 1975 and 1979 of Down's syndrome in the children living in high background radiation area, we made a follow-up investigation in 1985 and 1986. All the obtained data are analysed. 25258 children in high background radiation area were examined and 22 children with Down's syndrome were identified, the morbidity rate being 0.87%. 21837 children in control area were examined and four children with Down's syndrome were identified, the morbidity being 0.18%. There was a statistically significant difference between the two groups. It was noted that the occurrence of Down's syndrome was related to the maternal age but there was no evidence suggesting a close relationship between high background radiation and the development of Down's syndrome

Cutaneous Radiation Syndrome : Review of Assessment and Management

International Nuclear Information System (INIS)

El-Shanshoury, H.

2016-01-01

The cutaneous radiation syndrome (CRS) refers to a number of pathologies that may become a manifest after exposure of the skin to ionizing radiation. Signs and symptoms of the CRS appear within hours of exposure; however, the development of lesions can take days to years. The latent period for the manifestation of a specific pathology depends on the characteristics of the target cells responsible for the development of that lesion and the dose of radiation delivered to those target cells. The intensity and duration of the lesions are also dose dependent. Since the depth dose distribution of a radiation source depends on the radiation quality, the development of a specific lesion, its intensity and its duration is also expected to vary with radiation quality. The Cars may appear as an isolated lesion or as a number of lesions occurring simultaneously or over different time scales. In dealing with the cutaneous tissues, the concept of dose is meaningless unless it is associated with a reference depth dose distribution to indicate the level of injury to specific target cells. Large radiation doses to the skin can cause permanent hair loss, damaged sebaceous and sweat glands, atrophy, fibrosis decreased or increased skin pigmentation, and ulceration or necrosis of the exposed tissue. However, similar lesions may develop later after much lower doses. Death from the cutaneous syndrome could result in days or longer, depending on other conditions, such as dose rate, medical care and size of injury

Acute Radiation Syndrome (ARS) and its harmful effects on human health

International Nuclear Information System (INIS)

Khanam, Yasmin; Singh, Yogender

2012-01-01

After radiation exposure a series of many clinical syndromes appear that is called as Acute Radiation Syndrome (ARS). ARS also known as radiation toxicology or radiation sickness. Both low and higher doses radiation exposure on human body cause different types of radiation syndromes. These radiations may be ionizing radiations. X-rays and gamma rays etc. some times neutrons or radionuclides may also be deposited in human body and their effective doses cause major injuries or abnormalities even sometimes death also. ARS consist of a sequence of phased symptoms. These symptoms appear after the radiation exposure for several days to several months or sometimes for a long period or years. ARS depends on the quantity of absorbed radiation dose (rad0). ARS is characterized by an initial prodromal stage of malaise, nausea, vomiting, and diarrhea. Critical effects of ARS are Hematologic, that results infections to low white blood cells (WBC), bleeding due to low platelets and anemia due to low red blood cells (RBC), Gastrointestinal results nausea, vomiting, loss of appetite and abdominal pain (exposure doses of 600-1000 rad) and Neurovascular depending on the exposure dose. Neurovascular syndrome typically occurs at exposure doses greater than 1000 rad. It presents with neurological symptoms such as dizziness, headache, or decreased level of consciousness with an absence of vomiting. The clinical course of radiation sickness following a single intensive exposure to whole body radiation is characterized by three successive phases; a prodromal phase, which develops within minutes or hours after exposure, an ensuring latent period, which is relatively asymptomatic; and the main phase of the illness. Complete Blood Count (CBC) are helpful for the diagnosis for ARS. ARS may cause skin damage or loss of epidermis. Person suffering from nausea, vomiting, diarrhea should be admitted to well equipped hospitals or clinics. High exposured persons should be analysed CBC. Their

Granulocyte Colony-Stimulating Factor in the Treatment of Acute Radiation Syndrome: A Concise Review

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Michal Hofer

2014-04-01

Full Text Available This article concisely summarizes data on the action of one of the principal and best known growth factors, the granulocyte colony-stimulating factor (G-CSF, in a mammalian organism exposed to radiation doses inducing acute radiation syndrome. Highlighted are the topics of its real or anticipated use in radiation accident victims, the timing of its administration, the possibilities of combining G-CSF with other drugs, the ability of other agents to stimulate endogenous G-CSF production, as well as of the capability of this growth factor to ameliorate not only the bone marrow radiation syndrome but also the gastrointestinal radiation syndrome. G-CSF is one of the pivotal drugs in the treatment of radiation accident victims and its employment in this indication can be expected to remain or even grow in the future.

Significant fibrosis after radiation therapy in a patient with Marfan Syndrome

International Nuclear Information System (INIS)

Suarez, Eva M.; Knackstedt, Rebecca J.; Jenrette, Joseph M.

2014-01-01

Marfan syndrome is one of the collagen vascular diseases that theoretically predisposes patients to excessive radiation-induced fibrosis yet there is minimal published literature regarding this clinical scenario. We present a patient with a history of Marfan syndrome requiring radiation for a diagnosis of a right brachial plexus malignant nerve sheath tumor. It has been suggested that plasma transforming growth factor beta 1 (TGF-beta1) can be monitored as a predictor of subsequent fibrosis in this population of high risk patients. We therefore monitored the patient's TGF-beta1 level during and after treatment. Despite maintaining stable levels of plasma TGF-beta1, our patient still developed extensive fibrosis resulting in impaired range of motion. Our case reports presents a review of the literature of patients with Marfan syndrome requiring radiation therapy and the limitations of serum markers on predicting long-term toxicity.

Significant fibrosis after radiation therapy in a patient with Marfan Syndrome

Energy Technology Data Exchange (ETDEWEB)

Suarez, Eva M.; Knackstedt, Rebecca J.; Jenrette, Joseph M. [Medical University of South Carolina, Charleston (United States)

2014-09-15

Marfan syndrome is one of the collagen vascular diseases that theoretically predisposes patients to excessive radiation-induced fibrosis yet there is minimal published literature regarding this clinical scenario. We present a patient with a history of Marfan syndrome requiring radiation for a diagnosis of a right brachial plexus malignant nerve sheath tumor. It has been suggested that plasma transforming growth factor beta 1 (TGF-beta1) can be monitored as a predictor of subsequent fibrosis in this population of high risk patients. We therefore monitored the patient's TGF-beta1 level during and after treatment. Despite maintaining stable levels of plasma TGF-beta1, our patient still developed extensive fibrosis resulting in impaired range of motion. Our case reports presents a review of the literature of patients with Marfan syndrome requiring radiation therapy and the limitations of serum markers on predicting long-term toxicity.

Manifestations of radiation syndrome in pigs

International Nuclear Information System (INIS)

Kljajic, R.; Masic, Z.; Petrovic, B.; Ciganovic, P.

1996-01-01

Clinical and hematological changes in pigs after one-time acute radiation by high-energy-X-rays were described. The of animals was performed by using the linear accelerator of industrial type, with X-rays of 4 MeV, with semi-lethal dose (LD 50/30 = 3.20 Gy) bilaterally (50% of the dose from each side). The radiation syndrome in pigs developed through 4 stages of the disease: the prodromal stadium (1-3 days), the latent stadium (3-7 days), the stadium of expressed clinical symptoms (7-18 days) and the stadium of recovery (after 25 days). The basic characteristic of the disease was a strong haemorrhagic diathesis with expressed blood spots on the skin and bleedings from the nose and the anus as well as a rush decrease of blood dementia (leukocytes and thrombocytes) already 24 hours after radiation. (author)

Chernobyl 1996. New materials concerning acute radiation syndrome around Chernobyl

International Nuclear Information System (INIS)

Lupandin, Vladimir M.

2016-01-01

In 1996 we have succeeded in getting reliable data on radiation situation in the Khoiniki district. These were data of Civil Defence Headquarters of the Khoiniki district, remaining in private notes of the Chief of the Headquarters. Including the other data or materials, radiation syndromes in particular the acute are described. (J.P.N.)

Bone marrow stromal cell transplantation mitigates radiation-induced gastrointestinal syndrome in mice.

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Subhrajit Saha

Full Text Available Nuclear accidents and terrorism presents a serious threat for mass casualty. While bone-marrow transplantation might mitigate hematopoietic syndrome, currently there are no approved medical countermeasures to alleviate radiation-induced gastrointestinal syndrome (RIGS, resulting from direct cytocidal effects on intestinal stem cells (ISC and crypt stromal cells. We examined whether bone marrow-derived adherent stromal cell transplantation (BMSCT could restitute irradiated intestinal stem cells niche and mitigate radiation-induced gastrointestinal syndrome.Autologous bone marrow was cultured in mesenchymal basal medium and adherent cells were harvested for transplantation to C57Bl6 mice, 24 and 72 hours after lethal whole body irradiation (10.4 Gy or abdominal irradiation (16-20 Gy in a single fraction. Mesenchymal, endothelial and myeloid population were characterized by flow cytometry. Intestinal crypt regeneration and absorptive function was assessed by histopathology and xylose absorption assay, respectively. In contrast to 100% mortality in irradiated controls, BMSCT mitigated RIGS and rescued mice from radiation lethality after 18 Gy of abdominal irradiation or 10.4 Gy whole body irradiation with 100% survival (p<0.0007 and p<0.0009 respectively beyond 25 days. Transplantation of enriched myeloid and non-myeloid fractions failed to improve survival. BMASCT induced ISC regeneration, restitution of the ISC niche and xylose absorption. Serum levels of intestinal radioprotective factors, such as, R-Spondin1, KGF, PDGF and FGF2, and anti-inflammatory cytokines were elevated, while inflammatory cytokines were down regulated.Mitigation of lethal intestinal injury, following high doses of irradiation, can be achieved by intravenous transplantation of marrow-derived stromal cells, including mesenchymal, endothelial and macrophage cell population. BMASCT increases blood levels of intestinal growth factors and induces regeneration of the irradiated

Study of biological effects of varying mixtures of Cf-252 and gamma radiation on the acute radiation syndromes: Relevance to clinical radiotherapy of radioresistant cancer

International Nuclear Information System (INIS)

Maruyama, Y.; Wierzbicki, J.; Feola, J.M.

1993-01-01

Data for the 30 day bone marrow syndrome (BM-50) and the 6-10 day gastrointestinal (GI-50) syndrome for a one and two fraction schedule and acute and low dose rate irradiation using pure and mixed Cf-252 and photon radiation are presented. The radiation of Cf-252 is a mixture of neutrons and gamma rays. Balb/c mice of both sexes were total body irradiated with acute Co-60, low dose rate Cs-137 and Cf-252 using a 1 x and 2 x schedule. For low linear energy transfer radiations of Co-60 or Cs-137 there was expected to be an increase in the dose to produce the gastrointestinal and bone marrow syndromes with minimal change for Cf-252 neutrons. The proportion of photons in the Cf-252 radiation field were further altered by mixing Cs-137 with the Cf-252 sources and mice were total body irradiated with different proportions of photons to determine the effect on the radiation syndromes. The effects of mixing Cf-252 neutrons with different proportions of photons on the syndromes was determined. There was increase in BM-50 and GI-50 doses with fractionated or low dose rate photon irradiations and the dose modifying factors were 1.3-1.4 for the GI syndrome and 1.2 for the bone marrow syndrome. For Cf-252 there was minimal fractionation effect for the GI-50 syndrome, which increased by 1.1 for x 1 vs. x 2 fractions; for the BM-50 syndrome it rose by a 1.1 factor. For LDR Cs-137 the dose for the GI-50 syndrome rose 2.2-fold. For mixed neutron-photon radiation of 0%, 15%, 35%, and 65% η/γ mixtures, the dose to produce the BM-50 and GI-50 endpoints dropped sharply from 0 to 35% neutrons and remained flat thereafter. For major tissues such as the bone marrow and GI tract, Cf-252 behaved as high linear energy transfer for mixtures of neutrons and gamma rays when the radiations were delivered simultaneously at the low dose rates studied. 35 refs., 3 figs., 2 tabs

Reconstructive dosimetry for cutaneous radiation syndrome

Energy Technology Data Exchange (ETDEWEB)

Lima, C.M.A.; Lima, A.R.; Degenhardt, Ä.L.; Da Silva, F.C.A., E-mail: dasilva@ird.gov.br [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Valverde, N.J. [Fundacao Eletronuclear de Assistencia Medica, Rio de Janeiro, RJ (Brazil)

2015-10-15

According to the International Atomic Energy Agency (IAEA), a relatively significant number of radiological accidents have occurred in recent years mainly because of the practices referred to as potentially high-risk activities, such as radiotherapy, large irradiators and industrial radiography, especially in gammagraphy assays. In some instances, severe injuries have occurred in exposed persons due to high radiation doses. In industrial radiography, 80 cases involving a total of 120 radiation workers, 110 members of the public including 12 deaths have been recorded up to 2014. Radiological accidents in industrial practices in Brazil have mainly resulted in development of cutaneous radiation syndrome (CRS) in hands and fingers. Brazilian data include 5 serious cases related to industrial gammagraphy, affecting 7 radiation workers and 19 members of the public; however, none of them were fatal. Some methods of reconstructive dosimetry have been used to estimate the radiation dose to assist in prescribing medical treatment. The type and development of cutaneous manifestations in the exposed areas of a person is the first achievable gross dose estimation. This review article presents the state-of-the-art reconstructive dosimetry methods enabling estimation of local radiation doses and provides guidelines for medical handling of the exposed individuals. The review also presents the Chilean and Brazilian radiological accident cases to highlight the importance of reconstructive dosimetry. (author)

Hematological observations on two cases of acute radiation syndrome

International Nuclear Information System (INIS)

Jiang Benrong; Wang Guilin; Huang Shimin

1990-01-01

The hematological changes of two cases of acute radiation syndrome were observed. The physical doses of patients Liang and Yan were 3.5 Gy and 2.6 Gy respectively. According to the changes in WBC and platelet counts and the absolute count of lymphocytes and in comparison with the hematological data of the victims of Y-12 accident in USA in 1958 and those of previous accidents in China, Liang suffered from a moderate or moderate to severe degree, and Yan suffered from a moderate or moderate mild degree of hemopoietic form of acute radiation syndrome. This estimation was consistent with their clinical course and physical doses. Some blood cells appeared in the cytoplasm of megakaryocytes in bone marrow smears of those two cases. The mechanism of this phenomenon is discussed and its clinical significance remains to be studied

Radioprotective effect of Rapana thomasiana hemocyanin in gamma induced acute radiation syndrome

International Nuclear Information System (INIS)

Kindekov, Ivan; Vassilieva, Vladimir; Aljakova, Mitko; Mileva, Milka; Krastev, Dimo; Raynova, Yuliana; Idakieva, Krassimira; Doumanov, Lyuba

2014-01-01

The radioprotective effect of Rapana thomasiana hemocyanin (RtH) against radiation-induced injuries (stomach ulcers, survival time and endogenous haemopoiesis) and post-radiation recovery was investigated in male albino mice (C3H strain). Radiation course was in a dose of 7.5 Gy (LD 100/30 - dose that kills 100% of the mice at 30 days) from "1"3"7Cs with a dose of 2.05 Gy/ min. Radiation injuries were manifested by inducing 2 hematopoietic form of acute radiation syndrome. RtH was administered intraperitoneally in a single dose of 50, 100, 150 and 200 mg/kg body weight (b. w.) once a day for five consecutive days before irradiation. The results obtained showed that radiation exposure led to (1) 100% mortality rate, (2) ulceration in the stomach mucosa and (3) decrease formation of spleen colonies as a marker of endogenous haemopoiesis. Administration of RtH at a dose of 200 mg/kg provided better protection against radiation-induced stomach ulceration, mitigated the lethal effects of radiation exposure and recovered endogenous haemopoiesis versus irradiated but not supplemented mice. It could be expected that RtH will find a use in mitigating radiation induced injury and enhanced radiorecovery. Keywords: Rapana thomasiana hemocyanin; acute radiation syndrome; radioprotective effect; spleen colony assay; stomach ulcerations

Neurological aspects of acute radiation injuries

International Nuclear Information System (INIS)

Torubarov, F.S.; Bushmanov, A.Yu.

1999-01-01

Results of the most important clinical studies of human nervous system reactions to acute radiation, carried out at Neurology Clinic of the State Research Center of Russia - Institute of Biophysics are presented. Clinical picture of changes in the nervous system in acute radiation disease caused by homologous and heterologous external irradiation is described. Main neurological syndrome of extremely severe acute radiation disease: acute radiation encephalopathy, radiation toxic encephalopathy, and hemorrhagic syndrome of the central nervous system is distinguished. Relationship between neurological disorders and the geometry of exposure are considered [ru

Pretreatment with ascorbic acid prevents lethal gastrointestinal syndrome in mice receiving a massive amount of radiation

International Nuclear Information System (INIS)

Yamamoto, Tetsuo; Kinoshita, Manabu; Shinomiya, Nariyoshi; Hiroi, Sadayuki; Sugasawa, Hidekazu; Majima, Takashi; Seki, Shuhji; Matsushita, Yoshitaro; Saitoh, Daizoh

2010-01-01

While bone marrow or stem cell transplantation can rescue bone marrow aplasia in patients accidentally exposed to a lethal radiation dose, radiation-induced irreversible gastrointestinal damage (GI syndrome) is fatal. We investigated the effects of ascorbic acid on radiation-induced GI syndrome in mice. Ascorbic acid (150 mg/kg/day) was orally administered to mice for 3 days, and then the mice underwent whole body irradiation (WBI). Bone marrow transplantation (BMT) 24 h after irradiation rescued mice receiving a WBI dose of less than 12 Gy. No mice receiving 14 Gy-WBI survived, because of radiation-induced GI syndrome, even if they received BMT. However, pretreatment with ascorbic acid significantly suppressed radiation-induced DNA damage in the crypt cells and prevented denudation of intestinal mucosa; therefore, ascorbic acid in combination with BMT rescued mice after 14 Gy-WBI. DNA microarray analysis demonstrated that irradiation up-regulated expressions of apoptosis-related genes in the small intestine, including those related to the caspase-9-mediated intrinsic pathway as well as the caspase-8-mediated extrinsic pathway, and down-regulated expressions of these genes in ascorbic acid-pretreated mice. Thus, pretreatment with ascorbic acid may effectively prevent radiation-induced GI syndrome. (author)

Advances in the medical management of the severe cutaneous radiation syndrome

Energy Technology Data Exchange (ETDEWEB)

Carsin, H.; Stephannazi, J. [Percy Hospital, Clamart (France). Burn Treatment Centre; Gourmelon, P.

2000-05-01

The cutaneous radiation syndrome is a dose dependant complex pathological syndrome which follows a brief localized exposure and characterized by erythema, swelling, moist desquamation, ulceration and necrosis (25-30 Gy). Highly penetrating gamma radiation induces severe dose dependent lesions involving skin, subcutaneous tissue, muscle, vessels, nerves and occasionally, bony structures. The classical treatment of this syndrome includes the debridement of devitalized tissues, the application of bacteriostatic agents coated in non-adherent dressings, opiate-based drugs and in some cases the use of non-steroidal anti-inflammatory drugs. For ulceration and necrosis treatment, the classical surgery is ulcerectomy, necrectomy and amputation for the distal extremity injuries. For the profound et large necrosis, the lesion should be excised and the wound bed covered with a good quality, full-thickness skin graft. Unfortunately the delayed of appearance of this syndrome results often in non specialized medical treatment. Furthermore, because of the chronic evolution (months or years) the management of the cutaneous radiation syndrome has not been considered as a priority for the medical management. Recent accident like the Georgian accident demonstrated that new techniques such as artificial skin graft could change significantly patient prognosis. This technique is routinely used for thermal burn in specialized burn units. We realized the first application of this methodology in the field of radiopathology. An important factor of this technique is that in the case of recurrence of radionecrosis. Often observed, using this technique further grafting may be employed. However the success of this procedure depends on an effective control of the infection. These has sadly been illustrated in the last accident case in Peru where it was impossible to perform the artificial skin graft due to the persistence of a non-eradicated local infection. Whether this particular approach has a

Advances in the medical management of the severe cutaneous radiation syndrome

International Nuclear Information System (INIS)

Carsin, H.; Stephannazi, J.; Gourmelon, P.

2000-01-01

The cutaneous radiation syndrome is a dose dependant complex pathological syndrome which follows a brief localized exposure and characterized by erythema, swelling, moist desquamation, ulceration and necrosis (25-30 Gy). Highly penetrating gamma radiation induces severe dose dependent lesions involving skin, subcutaneous tissue, muscle, vessels, nerves and occasionally, bony structures. The classical treatment of this syndrome includes the debridement of devitalized tissues, the application of bacteriostatic agents coated in non-adherent dressings, opiate-based drugs and in some cases the use of non-steroidal anti-inflammatory drugs. For ulceration and necrosis treatment, the classical surgery is ulcerectomy, necrectomy and amputation for the distal extremity injuries. For the profound et large necrosis, the lesion should be excised and the wound bed covered with a good quality, full-thickness skin graft. Unfortunately the delayed of appearance of this syndrome results often in non specialized medical treatment. Furthermore, because of the chronic evolution (months or years) the management of the cutaneous radiation syndrome has not been considered as a priority for the medical management. Recent accident like the Georgian accident demonstrated that new techniques such as artificial skin graft could change significantly patient prognosis. This technique is routinely used for thermal burn in specialized burn units. We realized the first application of this methodology in the field of radiopathology. An important factor of this technique is that in the case of recurrence of radionecrosis. Often observed, using this technique further grafting may be employed. However the success of this procedure depends on an effective control of the infection. These has sadly been illustrated in the last accident case in Peru where it was impossible to perform the artificial skin graft due to the persistence of a non-eradicated local infection. Whether this particular approach has a

Clinical investigation of predictors of radiation-induced bronchiolitis obliterans organizing pneumonia syndrome after breast-conserving therapy

International Nuclear Information System (INIS)

Matsuyama, Tomohiko; Furusawa, Mitsuhiro; Yasunaga, Tadamasa; Nishimura, Reiki; Ohya, Natsuo

2011-01-01

We investigated 710 patients with breast cancer who received radiotherapy after breast-conserving surgery at our institution to evaluate the incidence of radiation-induced bronchiolitis obliterans organizing pneumonia (BOOP) syndrome focusing on the interval from irradiation to onset and the clinical presentation. The predictive value of age (≤50 or >50), chemotherapy and hormone therapy was statistically analyzed to determine whether these are risk factors for BOOP syndrome. Radiation-induced BOOP syndrome was seen in 1.3% (9/710). In most cases, the symptoms were mild and none of the patients required hospitalization. Eight patients (88.9%) responded well to steroid administration, but 5 of these patients relapsed after or during tapering of steroids. Although we could not detect significant risk factors for BOOP syndrome, a higher patient age was associated with a higher incidence of radiation-induced BOOP syndrome after breast-conserving therapy. (author)

Unusual case of recurrent SMART (stroke-like migraine attacks after radiation therapy syndrome

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Ramnath Santosh Ramanathan

2016-01-01

Full Text Available Stroke-like migraine attacks after radiation therapy (SMART syndrome is a rare delayed complication of cerebral radiation therapy. A 53-year-old female initially presented with headache, confusion and left homonymous hemianopia. Her medical history was notable for cerebellar hemangioblastoma, which was treated with radiation in 1987. Her initial brain MRI (magnetic resonance imaging revealed cortical enhancement in the right temporo-parieto-occipital region. She improved spontaneously in 2 weeks and follow-up scan at 4 weeks revealed no residual enhancement or encephalomalacia. She presented 6 weeks later with aphasia. Her MRI brain revealed similar contrast-enhancing cortical lesion but on the left side. Repeat CSF studies was again negative other than elevated protein. She was treated conservatively and recovered completely within a week. Before diagnosing SMART syndrome, it is important to rule out tumor recurrence, encephalitis, posterior reversible encephalopathy syndrome (PRES and stroke. Typically the condition is self-limiting, and gradually resolves.

Unusual case of recurrent SMART (stroke-like migraine attacks after radiation therapy) syndrome.

Science.gov (United States)

Ramanathan, Ramnath Santosh; Sreedher, Gayathri; Malhotra, Konark; Guduru, Zain; Agarwal, Deeksha; Flaherty, Mary; Leichliter, Timothy; Rana, Sandeep

2016-01-01

Stroke-like migraine attacks after radiation therapy (SMART) syndrome is a rare delayed complication of cerebral radiation therapy. A 53-year-old female initially presented with headache, confusion and left homonymous hemianopia. Her medical history was notable for cerebellar hemangioblastoma, which was treated with radiation in 1987. Her initial brain MRI (magnetic resonance imaging) revealed cortical enhancement in the right temporo-parieto-occipital region. She improved spontaneously in 2 weeks and follow-up scan at 4 weeks revealed no residual enhancement or encephalomalacia. She presented 6 weeks later with aphasia. Her MRI brain revealed similar contrast-enhancing cortical lesion but on the left side. Repeat CSF studies was again negative other than elevated protein. She was treated conservatively and recovered completely within a week. Before diagnosing SMART syndrome, it is important to rule out tumor recurrence, encephalitis, posterior reversible encephalopathy syndrome (PRES) and stroke. Typically the condition is self-limiting, and gradually resolves.

Radiation-induced camptocormia and dropped head syndrome. Review and case report of radiation-induced movement disorders

International Nuclear Information System (INIS)

Seidel, Clemens; Kuhnt, Thomas; Kortmann, Rolf-Dieter; Hering, Kathrin

2015-01-01

In recent years, camptocormia and dropped head syndrome (DHS) have gained attention as particular forms of movement disorders. Camptocormia presents with involuntary forward flexion of the thoracolumbar spine that typically increases during walking or standing and may severely impede walking ability. DHS is characterized by weakness of the neck extensors and a consecutive inability to extend the neck; in severe cases the head is fixed in a ''chin to chest position.'' Many diseases may underlie these conditions, and there have been some reports about radiation-induced camptocormia and DHS. A PubMed search with the keywords ''camptocormia,'' ''dropped head syndrome,'' ''radiation-induced myopathy,'' ''radiation-induced neuropathy,'' and ''radiation-induced movement disorder'' was carried out to better characterize radiation-induced movement disorders and the radiation techniques involved. In addition, the case of a patient developing camptocormia 23 years after radiation therapy of a non-Hodgkin's lymphoma of the abdomen is described. In total, nine case series of radiation-induced DHS (n = 45 patients) and - including our case - three case reports (n = 3 patients) about radiogenic camptocormia were retrieved. Most cases (40/45 patients) occurred less than 15 years after radiotherapy involving extended fields for Hodgkin's disease. The use of wide radiation fields including many spinal segments with paraspinal muscles may lead to radiation-induced movement disorders. If paraspinal muscles and the thoracolumbar spine are involved, the clinical presentation can be that of camptocormia. DHS may result if there is involvement of the cervical spine. To prevent these disorders, sparing of the spine and paraspinal muscles is desirable. (orig.) [de

Radiation-induced camptocormia and dropped head syndrome. Review and case report of radiation-induced movement disorders

Energy Technology Data Exchange (ETDEWEB)

Seidel, Clemens; Kuhnt, Thomas; Kortmann, Rolf-Dieter; Hering, Kathrin [Leipzig University, Department of Radiotherapy and Radiation Oncology, Leipzig (Germany)

2015-10-15

In recent years, camptocormia and dropped head syndrome (DHS) have gained attention as particular forms of movement disorders. Camptocormia presents with involuntary forward flexion of the thoracolumbar spine that typically increases during walking or standing and may severely impede walking ability. DHS is characterized by weakness of the neck extensors and a consecutive inability to extend the neck; in severe cases the head is fixed in a ''chin to chest position.'' Many diseases may underlie these conditions, and there have been some reports about radiation-induced camptocormia and DHS. A PubMed search with the keywords ''camptocormia,'' ''dropped head syndrome,'' ''radiation-induced myopathy,'' ''radiation-induced neuropathy,'' and ''radiation-induced movement disorder'' was carried out to better characterize radiation-induced movement disorders and the radiation techniques involved. In addition, the case of a patient developing camptocormia 23 years after radiation therapy of a non-Hodgkin's lymphoma of the abdomen is described. In total, nine case series of radiation-induced DHS (n = 45 patients) and - including our case - three case reports (n = 3 patients) about radiogenic camptocormia were retrieved. Most cases (40/45 patients) occurred less than 15 years after radiotherapy involving extended fields for Hodgkin's disease. The use of wide radiation fields including many spinal segments with paraspinal muscles may lead to radiation-induced movement disorders. If paraspinal muscles and the thoracolumbar spine are involved, the clinical presentation can be that of camptocormia. DHS may result if there is involvement of the cervical spine. To prevent these disorders, sparing of the spine and paraspinal muscles is desirable. (orig.) [German] In den letzten Jahren haben Bewegungsstoerungen von Wirbelsaeule und paraspinaler Muskulatur in

The present value of the diagnosis and therapy of the acute radiation syndrome

International Nuclear Information System (INIS)

Fliedner, T.M.

1975-01-01

The pathophysiological understanding of the acute radiation syndrome could be distinctly improved by the new research results in cell system physiology. It was thus possible to assign radiation-damaged persons to categories reflecting the most probable course of the disease within a few hours or days. This assignment has consequences for the therapeutical measures. Either nor measures or at least no stationary measures are necessary (recovery 'certain' or 'probable'), or the exposure was so great that death occurs within 2-3 days (recovery 'impossible'). The assigning to the category recovery 'improbable' or 'possible' leads to introducing special therapeutical measures where firstly an infection prophylaxis with antibiotics difficult to absorb in an isolation bed system ('sterile therapy') is necessary. Then, however, (in cases of certain inability to regenerate the bone marrow) a stem-call (bone marrow) transplantaion must be performed. (orig.) [de

A review of Down's syndrome studies and ionizing radiation

International Nuclear Information System (INIS)

Rose, K.S.B.

1994-01-01

This review collates results from 3 high dose (> 0.1 Gy) and 23 low dose epidemiological studies of parental radiation exposure and Down's syndrome incidence. A pattern of consistent results appears in 13 studies of irradiation received by women for diagnostic purposes. The pattern is an increase in Down's syndrome, the increase being approximately equivalent to an ovarian doubling dose of 20 mGy. The value is definitely not compatible with results from the high dose studies. Results from the other 10 low dose studies were used to test this value but most proved to be unsuitable for a variety of reasons. However, no associations between levels of high natural background and Down's syndrome have been observed in either New England or Aberdeen, which are areas in developed countries where reliable statistics ar collected. (author)

Effect of low doses of ionizing radiation on human health

International Nuclear Information System (INIS)

Kovalenko, A.N.

1990-01-01

Data are reported on the possible mechanism of biological effects of low doses of ionizing radiation on the human body. The lesioning effect of this radiation resulted in some of the persons in the development of disorders of the function of information and vegetative-regulatory systems determined as a desintegration syndrome. This syndrome is manifested in unspecific neuro-vegetative disorders of the function of most important physiological and homeostatic system of the body leading to weakening of the processes of compensation and adaptation. This condition is characterized by an unspecific radiation syndrome as distinct from acute or chronic radiation disease which is a specific radiation syndrome

SMART Syndrome: Case report of a rare complication after cerebral radiation therapy

International Nuclear Information System (INIS)

Truntzer, P.; Salze, P.; Monjour, A.; Gaultier, C.; Ahle, G.; Guillerme, F.; Boutenbat, G.; Atlani, D.; Stilhart, B

2012-01-01

The authors report a 71-year-old woman case who developed, 7 years after a cerebral radiation therapy for a parieto-occipital glioblastoma, a stroke-like migraine attacks after radiotherapy syndrome (SMART syndrome), a rare complication characterized by reversible neurologic deficits with migraine described after cerebral irradiation. Transient gyri-form reversible enhancement is found on MRI during crises. This case report allows discussing the clinical, iconographic presentation and the clinical outcome of this syndrome at the light of the literature publication. (authors)

Developing diagnostic guidelines for the acute radiation syndrome

International Nuclear Information System (INIS)

Densow, D.; Fliedner, T.M.; Kindler, H.

1996-01-01

Diagnostic guidelines seem to be promising for improving medical care. One aspect of a diagnostic guideline for the acute radiation syndrome has been tested against an extensive case history database. Subsequently, the guideline has been optimized for a small set of case histories. The improved performance has been proven by a test against the rest of the case history database

Acute radiation syndrome (ARS – treatment of the reduced host defense

Directory of Open Access Journals (Sweden)

Heslet L

2012-01-01

Full Text Available Lars Heslet1, Christiane Bay2, Steen Nepper-Christensen31Serendex ApS, Gentofte; 2University of Copenhagen, Medical Faculty, Copenhagen; 3Department of Head and Neck Surgery, Otorhinolaryngology, Køge University Hospital, Køge, DenmarkBackground: The current radiation threat from the Fukushima power plant accident has prompted rethinking of the contingency plan for prophylaxis and treatment of the acute radiation syndrome (ARS. The well-documented effect of the growth factors (granulocyte colony-stimulating factor [G-CSF] and granulocyte-macrophage colony-stimulating factor [GM-CSF] in acute radiation injury has become standard treatment for ARS in the United States, based on the fact that growth factors increase number and functions of both macrophages and granulocytes.Methods: Review of the current literature.Results: The lungs have their own host defense system, based on alveolar macrophages. After radiation exposure to the lungs, resting macrophages can no longer be transformed, not even during systemic administration of growth factors because G-CSF/GM-CSF does not penetrate the alveoli. Under normal circumstances, locally-produced GM-CSF receptors transform resting macrophages into fully immunocompetent dendritic cells in the sealed-off pulmonary compartment. However, GM-CSF is not expressed in radiation injured tissue due to defervescence of the macrophages. In order to maintain the macrophage’s important role in host defense after radiation exposure, it is hypothesized that it is necessary to administer the drug exogenously in order to uphold the barrier against exogenous and endogenous infections and possibly prevent the potentially lethal systemic infection, which is the main cause of death in ARS.Recommendation: Preemptive treatment should be initiated after suspected exposure of a radiation dose of at least ~2 Gy by prompt dosing of 250–400 µg GM-CSF/m2 or 5 µg/kg G-CSF administered systemically and concomitant inhalation of

Psychoneurological character of persons who had acute radiation syndrome

International Nuclear Information System (INIS)

Nyagu, A.I.; Khalyavka, I.G.; Loganovskij, K.N.; Plachinda, Yu.I.; Yur'ev, K.L.; Loganovskaya, T.K.

1996-01-01

Survivors of the Chernobyl accident who had an acute radiation syndrome (ARS,110 persons) were observed for 8 years after Chernobyl accident. It has been found that the cerebrovascular pathology and vertebral osteochondrosis rate increase as well as abnormal psychoorganic changes in personality and endogenic-like psychoorganic process, their rate being in proportion to the ARS heaviness. The EEG and evoked potentials have confirmed the dyscirculatory and toxic-metabolic organic disorders of the central nervous system as a result of irradiation in the remote period of the ARS consequences. It is necessary for early and differential diagnostic of the psychoneurological disorders after ARS to carry out the neuro- and psychophysiological examination as well as computer tomography, nucleic magnetic resonance and positron emission tomography of the brain

Radiation-induced liver injury showing low intensity on T2-weighted images noted in Budd-Chiari syndrome

Energy Technology Data Exchange (ETDEWEB)

Mori, Harushi [Tokyo Univ. (Japan). Graduate School of Medicine; Yoshioka, Hiroshi; Saida, Yukihisa; Itai, Yuji [Tsukuba Univ., Ibaraki (Japan). Inst. of Clinical Medicine; Mori, Kensaku [Tsukuba Univ., Ibaraki (Japan). Hospital; Ahmadi, T. [Shahid Beheshti Univ. of Medical Sciences, Teheran (Iran, Islamic Republic of); Okumura, Toshiyuki [Ibaraki Prefectural Central Hospital, Tomobe (Japan)

2002-04-01

Although it is documented that radiation can cause density or intensity changes on computed tomography or MR imaging in the irradiated hepatic parenchyma, few researchers have reported or understood the MR presentation of changes in hepatic parenchyma following radiotherapy in the patient with Budd-Chiari syndrome. The purpose of this study was to investigate the MR appearance of hepatic radiation injury in Budd-Chiari syndrome and to consider the underlying pathophysiology. The MR examinations of two patients with Budd-Chiari syndrome was compared with those of 11 patients without Budd-Chiari syndrome. The two groups, both of which suffered from hepatocellular carcinoma, underwent 50-72 Gy of proton-beam irradiation during a period of 14-43 days. Examinations including T1- and T2-weighted imaging, superparamagnetic iron oxide-enhanced imaging, and dynamic study were performed 3-10 weeks after the end of irradiation. Radiation-induced hepatic injury was observed as a low-intensity area on T2-weighted images and on delayed phase images of dynamic study in the Budd-Chiari patients, and as iso- or high-intensity areas on both images in the patients without Budd-Chiari syndrome. US-guided needle biopsy from the irradiated area in one patient with Budd-Chiari syndrome revealed mostly necrotic tissue and fibrous tissue. These MR features of hepatic radiation injury in Budd-Chiari syndrome were considered to be due to severe hepatic fibrosis. (author)

Dose effect relationships in cervical and thoracic radiation myelopathies

International Nuclear Information System (INIS)

Holdorff, B.

1980-01-01

The course and prognosis of radiation myelopathies are determined by 3 factors: the segmental (vertical) location of the lesion, the extent of the transverse syndrome (complete or incomplete) and the radiation dose. The median spinal dose in cervical radiation myelopathies with fatal outcome was higher than in survivals with an incomplete transverse syndrome. In thoracic radiation myelopathies a dose difference between complete and incomplete transverse syndromes could be found as well. Incomplete transverse syndromes as submaximum radiation injuries are more suitable for the determination of the spinal tolerance dose than complete transverse syndromes. The lowest threshold could be stated for cases following high-volume irradiation of the lymphatic system. (Auth.)

The effect of mitotic inhibitors on DNA strand size and radiation-associated break repair in Down syndrome fibroblasts

International Nuclear Information System (INIS)

Woods, W.G.; Steiner, M.E.; Kalvonjian, S.L.

1985-01-01

The effect of mitotic inhibitors on formation and repair of DNA breaks was studied in cultured fibroblasts from patients with Down syndrome in order to investigate the hypothesis that the karyotyping procedure itself may play a role in the increased chromosome breakage seen in these cells after gamma radiation exposure. Using the nondenaturing elution and alkaline elution techniques to examine fibroblasts from Down syndrome patients and from controls, no specific abnormalities in Down syndrome cells could be detected after exposure to mitotic inhibitors, including rate and extent of elution of DNA from filters as well as repair of radiation-induced DNA breaks. In both normal and Down syndrome cell strains, however, exposure to mitotic inhibitors was associated with a decrease in cellular DNA strand size, suggesting the presence of drug-induced DNA strand breaks. The mechanism of increased chromosome sensitivity of Down syndrome cells to gamma radiation remains unknown. (orig.)

Cardiovascular system and physical working capacity in patients who had acute radiation syndrome as the result of Chernobyl accident

International Nuclear Information System (INIS)

Belyi, D.; Gergel, O.; Kovalenko, A.

1996-01-01

The functional state of cardiovascular system has been studied since 1986 in 168 patients who had acute radiation syndrome as the result of Chernobyl accident. There was revealed a progressive increase of cardiovascular system pathology. The number of patients with pathological signs at ECG increased from 4.8 % in 1987 to 11.3 % in 1994 and with myocardial hypertrophy from 1.2 % to 22.6 %. The number of patients with coronary heart disease increased on 17.2% and with essential hypertension on 15.5%. The physical working capacity reduced to 50-60 % of a due level for healthy persons. Two patients suffered from acute myocardial infarction during this period of observation. Thirteenth patients died from 1987 to 1995. Among them 4 patient died in a result of acute cardiac failure. The development of cardiovascular pathology has no any correlation with a dose of exposure. Three factors of cardiovascular pathology growth are supposed

The acute radiation syndrome in the 137Cs Brazilian accident, 1987

International Nuclear Information System (INIS)

Valverde, N.J.; Cordeiro, J.M.; Oliveira, A.R.; Brandao Mello, C.E.

1989-01-01

Eight patients with the most severe degreed of bone marrow impairment are studied. Case descriptions are limited to manifestations and complications related to the 'Acute Radiation Syndrome' (ARS). Medical facilities, exams and therapeutic management are discussed. (MAC) [pt

Pathologic analysis on hyperplasia of mammary gland with different syndromes based on infrared radiation temperature of acupoints.

Science.gov (United States)

Wang, Yafang; Shen, Xueyong; Ying, Jian; Zheng, Juanjuan; Hu, Shengfang; Zhao, Ling; Deng, Haiping; Zhang, Haimeng

2012-09-01

To explore the pathologic characteristics of hyperplasia of the mammary gland (HMG) by observing differences in infrared radiation temperature of points of HMG in patients with different syndromes compared with healthy controls. A FLIR Systems Therma CAM P30 infrared thermal camera was used to detect the infrared temperature of Shanzhong (CV 17), Qimen (LR 14), Zhongwan (CV 12), Qihai (CV 6), Guanyuan (CV 4), Taixi (KI 3), and Taichong (LR 3) in 113 patients with HMG. Of these patients, 71 were placed in the Liver Qi stagnation group, 34 were placed in the Dysfunction of conception and thoroughfare vessels group, and 8 were placed in the Phlegm and blood stasis in combination group. The infrared radiation temperature of each point in the patients was compared with that of healthy controls, and the differences in the infrared radiation temperatures of the points in the patients were analyzed. Overall, the bilateral corresponding point in both the controls and patients exhibited no significant difference in infrared radiation temperature. In all cases, the infrared radiation temperature of the points from proximal to distal tended to decrease. In a comparison of the patients and controls, the infrared radiation temperature of the trunk points Shanzhong (CV 17), Qimen (LR 14), Zhongwan (CV 12), Qihai (CV 6), and Guanyuan (CV 4) of the patients was higher than that of the controls, while the infrared radiation temperature of the lower extremity points Taixi (KI 3) and Taichong (LR 3) was lower than that of the controls. Of these points, Shanzhong (CV 17) (P=0.0368), Zhongwan (CV 12) (P=0.0028), Qihai (CV 6) (P=0.0085), and Guanyuan (CV 4) (P=0.0018) showed significant differences. In a comparison of the corresponding point on the same side in the Liver Qi stagnation group and controls, the infrared radiation temperature of Shanzhong (CV 17) (P=0.0089), right-side Qi-men (LR 14) (P=0.0382), Zhongwan (CV 12) (P= 0.0000), Qihai (CV 6) (P=0.0011), and Guanyuan (CV 4) (P=0

The acute radiation syndrome: A study of ten cases and a review of the problem

Energy Technology Data Exchange (ETDEWEB)

Hempelmann, L.H.; Lisco, H.

1950-03-17

In this report ten cases of acute radiation syndrome are described resulting from two accidents occurring at the Los Alamos Scientific Laboratory of unique nature involving fissionable material. These cases are described in considerable detail. The report comprises ten sections. This volume, part II of the report, is comprised of sections entitled: (1) the Biological Basis for the Clinical Response seen in the Acute radiation Syndrome, (2) Clinical Signs and Symptoms, (3) Discussion of Hematological Findings, (4) Chemistry of the Blood and Urine, (5) Discussion of Pathological Findings, and (6) Reconsiderations of the Calculated Radiation Doses in Terms of the Observed Biological Response of the Patients. This report was prepared primarily for the clinician who is interested in radiation injuries and therefore emphasis has been placed on the correlation of clinical and pathological changes with the type of cytogenetic change known to be produced by ionizing radiation.

Susceptibility-weighted imaging in stroke-like migraine attacks after radiation therapy syndrome

Energy Technology Data Exchange (ETDEWEB)

Khanipour Roshan, Sara; Salmela, Michael B.; McKinney, Alexander M. [University Of Minnesota, Department of Radiology, Division of Neuroradiology, Minneapolis, MN (United States)

2015-11-15

Stroke-like migraine attacks after radiation therapy (SMART) syndrome has a characteristic clinical presentation and postcontrast T1WI MRI appearance. Susceptibility-weighted imaging (SWI) may help distinguish SMART from other disorders that may have a similar postcontrast MRI appearance. The MRI examinations of four patients with SMART syndrome are described herein, each of which included SWI, FLAIR, DWI, and postcontrast T1WI on the presenting and follow-up MRI examinations. In each, the initial SWI MRI demonstrated numerous susceptibility hypointensities <5 mm in size throughout the cerebrum, particularly within the periventricular white matter (PVWM), presumably related to radiation-induced cavernous hemangiomas (RICHs). By follow-up MRI, each postcontrast examination had demonstrated resolution of the gyriform enhancement on T1WI, without susceptibility hypointensities on SWI within those previously enhancing regions. These preliminary findings suggest that SWI may help identify SMART syndrome or at least help discriminate it from other disorders, by the findings of numerous susceptibility hypointensities on SWI likely representing RICHs, gyriform enhancement on T1WI, and postsurgical findings or appropriate clinical history. (orig.)

Overview of Brazilian industrial radiography accidents with cutaneous radiation syndrome

International Nuclear Information System (INIS)

Lima, C.M.A.; Silva, F.C.A. da

2017-01-01

It is well documented that industrial radiography is related to radiological accidents, which makes it the highest potential risk for human health. More than 80 radiological accidents happened in the world that includes 6 Brazilian accidents with Cutaneous Radiation Syndrome. Five of them happened with 192 Ir and one with 60 Co radioactive sources. Nineteen members of the public and 8 radiographers were involved. All of them suffered severe hands and fingers injuries. The Brazilian radiological accident happened in 1985 with 16 persons is analyzed showing causes, consequences, radiation doses and lessons learned. (author)

Central nervous system radiation injury in small animal models

International Nuclear Information System (INIS)

Kogel, A.J. van der

1991-01-01

Experimental studies on radiation injury in the central nervous system have been carried out in many species ranging from mouse to monkey. This review is restricted to studies in rodents irradiated with low linear energy transfer (LET) radiation. In this paper, the various rodent models of brain and spinal cord injury are described with particular emphasis on the pathology of different types of lesions and theories of their pathogenesis. Many of the initial studies were limited to relatively high single doses, but in later work more clinically relevant fractionated irradiation schemes were employed. This has led to the recognition of various types of early and late delayed injury that are analogous to the syndromes observed in humans. Two main pathways have been suggested for the pathogenesis, one involving predominantly the progressive loss of glial cells and the other involving vascular injury. The relative importance of both mechanisms will be discussed with respect to treatment conditions and to dose level in particular. An hypothesis is presented concerning the possible role of different cell types in the development of specific syndromes

Medical Management of Acute Radiation Syndromes : Immunoprophylaxis by Antiradiation Vaccine

Science.gov (United States)

Popov, Dmitri; Maliev, Vecheslav; Jones, Jeffrey; Casey, Rachael; Kedar, Prasad

Introduction: Traditionally, the treatment of Acute Radiation Syndrome (ARS) includes supportive therapy, cytokine therapy, blood component transfusions and even stem cell transplantation. Recommendations for ARS treatment are based on clinical symptoms, laboratory results, radiation exposure doses and information received from medical examinations. However, the current medical management of ARS does not include immune prophylaxis based on antiradiation vaccines or immune therapy with hyperimmune antiradiation serum. Immuneprophylaxis of ARS could result from stimulating the immune system via immunization with small doses of radiation toxins (Specific Radiation Determinants-SRD) that possess significant immuno-stimulatory properties. Methods: Principles of immuno-toxicology were used to derive this method of immune prophylaxis. An antiradiation vaccine containing a mixture of Hematotoxic, Neurotoxic and Non-bacterial (GI) radiation toxins, underwent modification into a toxoid forms of the original SRD radiation toxins. The vaccine was administered to animals at different times prior to irradiation. The animals were subjected to lethal doses of radiation that induced different forms of ARS at LD 100/30. Survival rates and clinical symptoms were observed in both control and vaccine-treated animals. Results: Vaccination with non-toxic doses of Radiation toxoids induced immunity from the elaborated Specific Radiation Determinant (SRD) toxins. Neutralization of radiation toxins by specific antiradiation antibodies resulted in significantly improved clinical symptoms in the severe forms of ARS and observed survival rates of 60-80% in animals subjected to lethal doses of radiation expected to induce different forms of ARS at LD 100/30. The most effective vaccination schedule for the antiradiation vaccine consisted of repeated injections 24 and 34 days before irradiation. The vaccine remained effective for the next two years, although the specific immune memory probably

Antiradiation Antitoxin IgG : Immunological neutralization of Radiation Toxins at Acute Radiation Syndromes.

Science.gov (United States)

Popov, Dmitri; Maliev, Slava

Introduction: High doses of radiation induce apoptotic necrosis of radio-sensitive cells. Mild doses of radiation induce apoptosis or controlled programmed death of radio-sensitive cells with-out development of inflammation and formation of Radiation Toxins. Cell apoptotic necrosis initiates Radiation Toxins (RT)formation. Radiation Toxins play an important role as a trig-ger mechanism for inflammation development and cell lysis. If an immunotherapy approach to treatment of the acute radiation syndromes (ARS) were to be developed, a consideration could be given to neutralization of radiation toxins (Specific Radiation Determinants-SRD) by specific antiradiation antibodies. Therapeutic neutralization effects of the blocking anti-radiation antibodies on the circulated RT had been studied. Radiation Toxins were isolated from the central lymph of irradiated animals with Cerebrovascular(Cv ARS),Cardiovascular (Cr ARS),Gastrointestinal(Gi ARS) and Haemopoietic (Hp ARS) forms of ARS. To accomplish this objective, irradiated animals were injected with a preparation of anti-radiation immunoglobulin G (IgG) obtained from hyperimmune donors. Radiation-induced toxins that we call Specific Radiation Determinants (SRD) possess toxic (neurotoxic, haemotoxic) characteristics as well as specific antigenic properties. Depending on direct physiochemical radiation damage, they can induce development of many of the pathological processes associated with ARS. We have tested several specific hyperimmune IgG preparations against these radiation toxins and ob-served that their toxic properties were neutralized by the specific antiradiation IgGs. Material and Methods: A scheme of experiments was following: 1.Isolation of radiation toxins (RT) from the central lymph of irradiated animals with different form of ARS. 2.Transformation of a toxic form of the RT to a toxoid form of the RT. 3.Immunization of radiation naive animals. Four groups of rabbits were inoculated with a toxoid form of SRD

Blood status in the long-term radiation syndrome

Directory of Open Access Journals (Sweden)

Galstyan I.A.

2013-12-01

Full Text Available Aims: to reveal regularities of change of peripheral blood indicators in the long-term acute radiation syndrome (ARS depending on its initial severity and existence of various somatic diseases. Material and methods. Clinical he-matologic materials from 114 patients in the long-term ARS (from 1,5 to more than 20 years after radiation accident, developed as a result of gamma beta exposure are presented. Results. In the period of the late radiation effect average values of peripheral blood are in physiological norm limits. However at some patients there are temporary superficial cytopenic conditions (thrombocytopenia — 22,7%, a leukopenia — 12,2%, a neutropenia — 13,1%, a lymphocytope-nia — 10,5%. Conclusion. As a result of a dynamic research it is revealed that in the remote terms of ARS (from 1,5 to more than 20 years after radiation average group levels of erythrocytes, leukocytes, neutrophils and lymphocytes in blood are in limits of physiological norm. However in the individual analysis of a functional state of blood at a part of patients are noted not stable cytopenic states.

Granulocyte Colony-Stimulating Factor in the Treatment of Acute Radiation Syndrome: A Concise Review

Czech Academy of Sciences Publication Activity Database

Hofer, Michal; Pospíšil, Milan; Komůrková, Denisa; Hoferová, Zuzana

2014-01-01

Roč. 19, č. 4 (2014), s. 4770-4778 ISSN 1420-3049 R&D Projects: GA ČR(CZ) GAP303/11/0128 Institutional support: RVO:68081707 Keywords : granulocyte colony-stimulating factor * radiation accident s * acute radiation syndrome Subject RIV: BO - Biophysics Impact factor: 2.416, year: 2014

Radiation-induced leiomyosarcoma of the great vessels presenting as superior vena cava syndrome

International Nuclear Information System (INIS)

Weiss, K.S.; Zidar, B.L.; Wang, S.

1987-01-01

A patient with a pleomorphic intravascular leiomyosarcoma of the great vessels of the neck and mediastinum presented clinically with a superior vena cava syndrome. A latent period of 29 years elapsed between receiving orthovoltage radiation to the neck and right side of chest to treat recurrent ganglioneuroblastoma, and the appearance of a leiomyosarcoma and subsequent recurrences. The patient underwent partial resection of the tumor, received adjunct chemotherapy, and was shown to be free of disease by clinical tests and by magnetic resonance imaging (MRI) 17 months after completion of chemotherapy. The criteria for the diagnosis of radiation-induced sarcomas are reviewed in relation to the present case. The critical role of magnetic resonance imaging in both the diagnosis and continued follow-up of the patient is described. This would appear to be the first reported case of radiation-induced intravascular leiomyosarcoma of the great vessels of the neck and mediastinum presenting as a superior vena cava syndrome

Overview of Brazilian industrial radiography accidents with cutaneous radiation syndrome

Energy Technology Data Exchange (ETDEWEB)

Lima, C.M.A.; Silva, F.C.A. da, E-mail: dasilva@ird.gov.br [Instituto de Radioproteção e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

2017-07-01

It is well documented that industrial radiography is related to radiological accidents, which makes it the highest potential risk for human health. More than 80 radiological accidents happened in the world that includes 6 Brazilian accidents with Cutaneous Radiation Syndrome. Five of them happened with {sup 192}Ir and one with {sup 60}Co radioactive sources. Nineteen members of the public and 8 radiographers were involved. All of them suffered severe hands and fingers injuries. The Brazilian radiological accident happened in 1985 with 16 persons is analyzed showing causes, consequences, radiation doses and lessons learned. (author)

Experimental treatment of gastrointestinal radiation syndrome in dogs

International Nuclear Information System (INIS)

Mao Bingzhi; Chen Dezheng; Liu Zuobin

1986-01-01

Gastrointestinal radiation syndrome occurred in 27 mongrel dogs irradiated with 9-12 Gy of 60 Co γ-rays. Six of them received autologous bone marrow transplantation (auto-BMT), 10 animals were treated with symptomatic and supportive measures only, and the remaining 11 dogs served as controls without any treatment. All animals of the latter two groups died between 3 and 11 days after irradiation without any evidence of hematopoietic recovery. Recovery of gastrointestinal injury was found in 7 dogs treated with symptomatic and supportive measures only. Of 6 dogs having received auto-BMT 2 died 15 days after irradiation, 3 survived over 30 days with recovery of gastrointestinal and hematopoietic injury but died of distemper later, and the other one, still alive, has survived for more than 4 years. The results show that the effective measures for gastrointestinal radiatin syndrome are BMT and symptomatic therapy

The status of the nervous system of persons exposed to occupational chronic radiation (45 years of observation)

International Nuclear Information System (INIS)

Azizova, T.V.

2000-01-01

The retrospective study of a state of the nervous system in dynamics in 1090 workers of the first Russian atomic enterprise was carried out. The main unfavorable factor of occupational effect in the yearly years of work (1948-1954) was chronic external gamma-radiation in doses from 0.4 to 5.7 Gy per one year. During maximal radiation exposure a vegetative dystonia of a hypotensive type (51.8%), asthenic syndrome (35.2%) and syndrome of microorganic changes of the central nervous system (5.9%) were most frequently registered in workers. Frequency and the periods of the development of these syndromes depended on an annual exposure dose (p<0.001). Alongside with an occupational chronic exposure non-radiation factors (age at the moment of an exposure, initial state of health, intense nature of job regarding nervous loads) exerted the certain influence on the development of these neurologic syndromes. In the long-term period after an exposure the cerebrovascular diseases were most frequent. Their incidence was naturally related with the age of patients. However, it was determined that the initial clinical manifestations of a cerebral atherosclerosis in persons exposed to irradiation in doses more of 2.5 Gy/year were registered in younger age than in control group. The frequency of their development depended on an annual dose of a gamma-irradiation, age at the moment of an exposure, degree of manifestation and duration of preceding vegetative - vascular disorders. (author)

Investigation and analysis of etiology of down's syndrome in children of high background radiation area

International Nuclear Information System (INIS)

Zha Yongru

1985-01-01

In order to find out what caused the differences in incidences of Down's syndrome between the children in high background radiation area and those in control area, investigation and analysis were carried ou in 5 aspects based on the original data and the information from the previous survey. These are: the incidences of congenital malformations in normal areas, the age distribution of children examined, the maternal age, the dates of birth of afflicted children, and the radiation exposure of mothers. The results suggested that the higher incidence of Down's syndrome in high background area might be related to the materal age. Further studies are needed to arrive at a conclusion

Radiation monitoring system

International Nuclear Information System (INIS)

Takeuchi, Nobuyoshi; Fujimoto, Toshiaki; Nagama, Hideyo

2007-01-01

A positive outlook toward nuclear power plants and a higher level of technologies for using radiation in the medical field are trends that are spreading throughout the world, and as a consequence, demand is increasing for equipment and systems that measure and control radiation. Equipment ranging from radiation detection and measurement devices to computer-based radiation management systems will be set up in overseas. Products that depend on overseas specifications based on IEC and other international standards are being developed. Fuji Electric is advancing the overseas deployment of radiation monitoring systems by adopting measures that will ensure the reliability and traceability of radiation equipment. (author)

2013 Space Radiation Standing Review Panel Status Review for: The Risk of Acute and Late Central Nervous System Effects from Radiation Exposure, The Risk of Acute Radiation Syndromes Due to Solar Particle Events (SPEs), The Risk Of Degenerative Tissue Or Other Health Effects From Radiation Exposure, and The Risk of Radiation Carcinogenesis

Science.gov (United States)

2014-01-01

The Space Radiation Standing Review Panel (from here on referred to as the SRP) was impressed with the strong research program presented by the scientists and staff associated with NASA's Space Radiation Program Element and National Space Biomedical Research Institute (NSBRI). The presentations given on-site and the reports of ongoing research that were provided in advance indicated the potential Risk of Acute and Late Central Nervous System Effects from Radiation Exposure (CNS) and were extensively discussed by the SRP. This new data leads the SRP to recommend that a higher priority should be placed on research designed to identify and understand these risks at the mechanistic level. To support this effort the SRP feels that a shift of emphasis from Acute Radiation Syndromes (ARS) and carcinogenesis to CNS-related endpoints is justified at this point. However, these research efforts need to focus on mechanisms, should follow pace with advances in the field of CNS in general and should consider the specific comments and suggestions made by the SRP as outlined below. The SRP further recommends that the Space Radiation Program Element continue with its efforts to fill the vacant positions (Element Scientist, CNS Risk Discipline Lead) as soon as possible. The SRP also strongly recommends that NASA should continue the NASA Space Radiation Summer School. In addition to these broad recommendations, there are specific comments/recommendations noted for each risk, described in detail below.

Cellular therapy to treat ionizing radiation-induced cutaneous radiation syndrome: 2 cases report

International Nuclear Information System (INIS)

Benderitter, M.; Chapel, A.; Trompier, F.; Clairand, I.; Bottolier-Depois, J.F.; Gourmelon, P.; Bey, E.; Lataillade, J.J.

2008-01-01

Full Text: Localized irradiation at high dose exposition could induce severe radiation burns characterized by the occurrence of unpredictable successive inflammatory waves leading to the extension in surface and depth of necrotic processes. The medical management of these severe radiation burns remains today a challenging issue unresolved by the classical therapeutical approach. For the first time, two victims (accident of Chile, 2006 and accident of Senegal, 2007) accidentally exposed to an iridium gammagraphy radioactive source experienced a new and innovative therapeutic strategy combining dosimetry-guided surgery lesion excision and injection of MSC. The clinical evolution was remarkable. The clinical transfer of this therapeutic option was possible based on the research perform in the Institute and the IRSN/Percy hospital cooperation. Our data suggested that cellular therapy based on Mesenchymal Stem Cell (MSC) injection could be used to repair numerous injured tissues. We have studied the potential use of human MSC (hMSC) in order to limit radiation-induced skin lesions. Our pre-clinical data suggest a possible use of hMSC for the treatment of the early phase of the cutaneous radiation syndrome. The understanding of the precise healing mechanisms of hMSC in animal model is under investigation. These results will be helpful to generalize this innovative therapy to the treatment of other radiological complications. (author)

Radiation myelopathy

International Nuclear Information System (INIS)

Berlit, P.

1987-01-01

After a review of the world literature, the case histories of 43 patients with radiation myelopathy are analyzed. In 1 patient there was a radiation injury of the medulla oblongata, in 2, cervical, in 28, thoracic, and in 12, lumbosacral. In the medulla oblongata lesion an alternans syndrome resulted. The patients with cervical and thoracic radiation myelopathies presented with a Brown-Sequard syndrome, a spinalis anterior syndrome or a transversal syndrome with pyramidal and spinothalamic tract involvement as the most prominent signs. For this group the term 'pyramidal-spinothalamic radiation myelopathy' is proposed. In lumbosacral radiation lesions a pure anterior horn syndrome may lead to spinothalamic tract involvement and the development of a cauda conus syndrome. The clinical presentation of these cases suggests that the location of the radiation lesion is most likely the region of the conus medullaris. The most frequent initial symptom was dysesthesia; the patients complained of burning pain or a feeling of coldness. Usually the neurological deficits were progressive, in pyramidal-spinothalamic radiation myelopathy over 12 months in average, in lumbosacral radiation lesions up to 10 years. The latent period between the finish of radiation therapy and the first neurological signs was 8 months (median) in cervical and thoracic myelopathy and 33 months in lumbosacral lesions. For the entire group of 43 patients there was an inverse relationship between the radiation dose (ret) and the latent period. A positive relation could be demonstrated between the age of patients at the time of radiation therapy and the latent period. Patients simultaneously receiving cytostatic drugs presented after a longer latent period than the remaining group. (orig./MG)

Radiation therapy for Kasabach-Merritt syndrome. Analysis of unfavorable factors in 5 children

International Nuclear Information System (INIS)

Kawamori, Jiro; Saito, Tsutomu; Tanaka, Yoshiaki; Sato, Katsuhiko.

1996-01-01

During the past 10 years, five infants with Kasabach-Merritt syndrome (K-M) receiving radiation therapy were reported. We investigated whether radiation therapy for K-M was useful and what the unfavorable factors of K-M were. During the past 10 years, we have treated five infants with K-M. The syndrome occurred at ages ranging from birth to 4 months. The incidence of female to male ratio was 3:2. Among 5 cases, the site of hemangioma was as follows; shoulder, anterior chest wall, lower abdominal wall, face and neck and inguinal site. All 5 cases received medication to control the coagulopathy including prednisone and blood transfusion at first. Because the platelet count and the bleeding tendency did not improve in any case, these cases received radiation therapy. Total dose ranged from 5 to 10 Gy and fraction-size ranged from 0.5 to 1.75 Gy. Irradiation session was 2 or 3 times per week. In 5 cases, 4 cases showed cure of bleeding tendency and disappearance of tumor, and survived. In these 4 cases, normalization of platelet count was obtained at the early phase of dose ranging from 3 to 5 Gy by radiation therapy. In the remaining case, bleeding tendency was improved at the late phase by initial radiation therapy, however, after that immediately relapsed. In this case, the salvage radiation therapy was not effective and she died from airway obstruction. This case was of neonatal age and had bulky neck tumor. We recognized that radiation therapy was effective for K-M. A serious case was of neonatal age and had bulky neck tumor. It was estimated that the unfavorable factors of K-M were neonatal case and bulky neck tumor case. (author)

Protective Role of R-spondin1, an Intestinal Stem Cell Growth Factor, against Radiation-Induced Gastrointestinal Syndrome in Mice

OpenAIRE

Bhanja, Payel; Saha, Subhrajit; Kabarriti, Rafi; Liu, Laibin; Roy-Chowdhury, Namita; Roy-Chowdhury, Jayanta; Sellers, Rani S.; Alfieri, Alan A.; Guha, Chandan

2009-01-01

Background Radiation-induced gastrointestinal syndrome (RIGS) results from a combination of direct cytocidal effects on intestinal crypt and endothelial cells and subsequent loss of the mucosal barrier, resulting in electrolyte imbalance, diarrhea, weight loss, infection and mortality. Because R-spondin1 (Rspo1) acts as a mitogenic factor for intestinal stem cells, we hypothesized that systemic administration of Rspo1 would amplify the intestinal crypt cells and accelerate the regeneration of...

Evaluation of the Components of the North Carolina Syndromic Surveillance System Heat Syndrome Case Definition.

Science.gov (United States)

Harduar Morano, Laurel; Waller, Anna E

To improve heat-related illness surveillance, we evaluated and refined North Carolina's heat syndrome case definition. We analyzed North Carolina emergency department (ED) visits during 2012-2014. We evaluated the current heat syndrome case definition (ie, keywords in chief complaint/triage notes or International Classification of Diseases, Ninth Revision, Clinical Modification [ ICD-9-CM] codes) and additional heat-related inclusion and exclusion keywords. We calculated the positive predictive value and sensitivity of keyword-identified ED visits and manually reviewed ED visits to identify true positives and false positives. The current heat syndrome case definition identified 8928 ED visits; additional inclusion keywords identified another 598 ED visits. Of 4006 keyword-identified ED visits, 3216 (80.3%) were captured by 4 phrases: "heat ex" (n = 1674, 41.8%), "overheat" (n = 646, 16.1%), "too hot" (n = 594, 14.8%), and "heatstroke" (n = 302, 7.5%). Among the 267 ED visits identified by keyword only, a burn diagnosis or the following keywords resulted in a false-positive rate >95%: "burn," "grease," "liquid," "oil," "radiator," "antifreeze," "hot tub," "hot spring," and "sauna." After applying the revised inclusion and exclusion criteria, we identified 9132 heat-related ED visits: 2157 by keyword only, 5493 by ICD-9-CM code only, and 1482 by both (sensitivity = 27.0%, positive predictive value = 40.7%). Cases identified by keywords were strongly correlated with cases identified by ICD-9-CM codes (rho = .94, P definition through the use of additional inclusion and exclusion criteria substantially improved the accuracy of the surveillance system. Other jurisdictions may benefit from refining their heat syndrome case definition.

The Hematopoietic Syndrome of the Acute Radiation Syndrome in Rhesus Macaques: A Systematic Review of the Lethal Dose Response Relationship.

Science.gov (United States)

MacVittie, Thomas J; Farese, Ann M; Jackson, William

2015-11-01

Well characterized animal models that mimic the human response to potentially lethal doses of radiation are required to assess the efficacy of medical countermeasures under the criteria of the U.S. Food and Drug Administration "animal rule." Development of a model requires the determination of the radiation dose response relationship and time course of mortality and morbidity across the hematopoietic acute radiation syndrome. The nonhuman primate, rhesus macaque, is a relevant animal model that may be used to determine the efficacy of medical countermeasures to mitigate major signs of morbidity and mortality at selected lethal doses of total body irradiation. A systematic review of relevant studies that determined the dose response relationship for the hematopoietic acute radiation syndrome in the rhesus macaque relative to radiation quality, dose rate, and exposure uniformity has never been performed. The selection of data cohorts was made from the following sources: Ovid Medline (1957-present), PubMed (1954-present), AGRICOLA (1976-present), Web of Science (1954-present), and U.S. HHS REPORT (2002 to present). The following terms were used: Rhesus, total body-irradiation, total body x irradiation, TBI, irradiation, gamma radiation, hematopoiesis, LD50/60, Macaca mulatta, whole-body irradiation, nonhuman primate, NHP, monkey, primates, hematopoietic radiation syndrome, mortality, and nuclear radiation. The reference lists of all studies, published and unpublished, were reviewed for additional studies. The total number of hits across all search sites was 3,001. There were a number of referenced, unpublished, non-peer reviewed government reports that were unavailable for review. Fifteen studies, 11 primary (n = 863) and four secondary (n = 153) studies [n = 1,016 total nonhuman primates (NHP), rhesus Macaca mulatta] were evaluated to provide an informative and consistent review. The dose response relationships (DRRs) were determined for uniform or non-uniform total

Syndromes that Link the Endocrine System and Genitourinary Tract.

Science.gov (United States)

Özlük, Yasemin; Kılıçaslan, Işın

2015-01-01

The endocrine system and genitourinary tract unite in various syndromes. Genitourinary malignancies may cause paraneoplastic endocrine syndromes by secreting hormonal substances. These entities include Cushing`s syndrome, hypercalcemia, hyperglycemia, polycythemia, hypertension, and inappropriate ADH or HCG production. The most important syndromic scenarios that links these two systems are hereditary renal cancer syndromes with specific genotype/phenotype correlation. There are also some very rare entities in which endocrine and genitourinary systems are involved such as Carney complex, congenital adrenal hyperplasia and Beckwith-Wiedemann syndrome. We will review all the syndromes regarding manifestations present in endocrine and genitourinary organs.

Preliminary early evaluation of radiation acute syndrome severity in an animal model

International Nuclear Information System (INIS)

Gimenez, J.C.; Nasazzi, N.B.; Taja, M.R.; Nagle, C.; Dubner, D.; Di Rizzio, C.

1992-01-01

To improve the knowledge of Radiation Acute Syndrome radiopathological picture, whole body x-rays irradiation at 2Gy of a primate (Cebus apella paraguayanus) used as model has been performed. Early evaluations of clinical symptoms and dose and damage biological indicators have shown that this primate has given out similar responses to those of man. (author)

Preliminary early evaluation of radiation acute syndrome severity in an animal model

Energy Technology Data Exchange (ETDEWEB)

Gimenez, J.C.; Nasazzi, N.B.; Taja, M.R. [Comision Nacional de Energia Atomica, (Argentina); Nagle, C. [Centro de Educacion Medica e Investigaciones Clinicas (Argentina); Dubner, D. [Comision Nacional de Energia Atomica, (Argentina); Di Rizzio, C. [Academia Nacional de Medicina (Argentina)

1992-07-01

To improve the knowledge of Radiation Acute Syndrome radiopathological picture, whole body x-rays irradiation at 2Gy of a primate (Cebus apella paraguayanus) used as model has been performed. Early evaluations of clinical symptoms and dose and damage biological indicators have shown that this primate has given out similar responses to those of man. (author)

The inflammatory response plays a major role in the acute radiation syndrome induced by fission radiation

International Nuclear Information System (INIS)

Agay, D.; Chancerelle, Y.; Hirodin, F.; Mathieu, J.; Multon, E.; Van Uye, A.; Mestries, J.C.

1997-01-01

At high dose rates, both gamma and neutron irradiation induce an acute inflammatory syndrome with huge intercellular communication disorders. This inflammatory syndrome evolves in two phases, separated by a latency phase. During the prodromal phase, the molecular and cellular lesions induced by free radicals trigger an initial response which associates cellular repair and multicellular interactions involving both humoral and nervous communications. A large part of perturbations constitute a non specific inflammatory syndrome and clinically silent coagulation disorders which are linked by common intercellular mediators. All these perturbations are rapidly reversible and there is no correlation between the radiation dose and the severity of the response. During the manifest-illness phase, both inflammatory and coagulation disorders resume, slightly preceding the clinical symptoms. Biochemical symptoms are moderate in the animals which will survive, but they escape regulatory mechanisms in those which will die, giving rise to a vicious circle. These biochemical disorders are largely responsible for the death. With lower dose rates, it cannot be excluded that great cellular communication disorders take place at the tissue level, with limited blood modifications. This aspect should be taken into account for the optimization of cytokine therapies. (authors)

New type radiation management system

International Nuclear Information System (INIS)

Mogi, Kenichi; Uranaka, Yasuo; Fujita, Kazuhiko

2001-01-01

The radiation management system is a system to carry out entrance and leaving room management of peoples into radiation management area, information management on radiation obtained from a radiation testing apparatus, and so on. New type radiation management system developed by the Mitsubishi Electric Corp. is designed by concepts of superior maintenance and system practice by using apparatus and its interface with standard specification, upgrading of processing response by separating exposure management processing from radiation monitoring processing on a computer, and a backup system not so as to lose its function by a single accident of the constructed computer. Therefore, the system is applied by the newest hardware, package software, and general use LAN, and can carry out a total system filled with requirements and functions for various radiation management of customers by preparing a basic system from radiation testing apparatus to entrance and leaving room management system. Here were described on outline of the new type management system, concept of the system, and functions of every testing apparatus. (G.K.)

Radiation control system

International Nuclear Information System (INIS)

Murao, Mitsuo.

1985-01-01

Purpose: To rapidly and suitably performing planning and designation by radiation-working control systems in the radiation controlled area of nuclear power plant. Method: Various informations regarding radiation exposure are arranged and actual exposure data are statistically stored, to thereby perform forecasting calculation for the radiation exposure upon workings in the plurality of working regions in the radiation controlled area. Based on the forecast values and the registered workers' exposure dose in the past workings are alocated successively such that the total exposure does upon conducting the workings is less than the limited value, to prepare working plans in the areas. Further, procedures for preparing a series of documents regarding the workings in the radiation area are automated to rapidly and properly provide the informations serving to the planning and designation for the radiation workings. As a result, the radiation managers' burnden can be mitigated and an efficient working management system can be provided, in view of the exposure management and personal management. (Kamimura, M.)

Principals Of Radiation Toxicology: Important Aspects.

Science.gov (United States)

Popov, Dmitri; Maliev, Slava; Jones, Jeffrey

“All things are poison, and nothing is without poison; only the dose permits something not to be poisonous.” Paracelsus Key Words: Radiation Toxins (RT), Radiation Toxicants (RTc), Radiation Poisons (RP), Radiation Exposure (RE), Radiation Toxicology is the science about radiation poisons. [D.Popov et al. 2012,J.Zhou et al. 2007,] Radiation Toxins is a specific proteins with high enzymatic activity produced by living irradiated mammals. [D.Popov et al. 2012,] Radiation Toxicants is a substances that produce radiomimetics effects, adverse biological effects which specific for radiation. [D.Popov et al. 2012,] Radiation Toxic agent is specific proteins that can produce pathological biological effects specific for physical form of radiation.[D.Popov et al. 1990,2012,V. Maliev 2007] Different Toxic Substances isolated from cells or from blood or lymph circulation. [Kudriashov I. et al. 1970, D.Popov et al. 1990,2012,V. Maliev et al. 2007,] Radiation Toxins may affects many organs or specific organ, tissue, specific group of cells. [Kudriashov I. et al. 1970, D.Popov et al. 1990,2012,V. Maliev et al. 2007] For example: Radiation Toxins could induce collective toxic clinical states to include: systemic inflammatory response syndrome (SIRS),toxic multiple organ injury (TMOI), toxic multiple organ dysfunction syndromes (TMODS),and finally, toxic multiple organ failure (TMOF). [T. Azizova et al. 2005, Konchalovsky et al., 2005, D. Popov et al 2012] However, Radiation Toxins could induce specific injury of organs or tissue and induce Acute Radiation Syndromes such as Acute Radiation Cerebrovascular Syndrome, Acute Radiation Cardiovascular Syndrome, Acute Radiation Hematopoietic Syndrome, Acute Radiation GastroIntestinal Syndrome. [ D.Popov et al. 1990, 2012, V. Maliev et al. 2007] Radiation Toxins correlates with Radiation Exposure and the dose-response relationship is a fundamental and essential concept in classic Toxicology and Radiation Toxicology.[ D.Popov et al

Down's syndrome and related abnormalities in an area of high background radiation in coastal Kerala

International Nuclear Information System (INIS)

Kochupillai, N.; Verma, I.C.; Grewal, M.S.; Ramalingaswami, V.

1976-01-01

It is stated that in a coastal area of Kerala, Southern India, the background radiation is between 1500 and 3000 mR/yr, this being due to the presence of Th-containing monazite mineral in the soil. During an epidemiological study of modular lesions of the thyroid in this area an apparently high prevalence of Down's syndrome and other forms of severe mental retardation was observed. A house-to-house survey of relevant abnormalities in this area was made, and also in a comparable control area without high background radiation. The frequency of chromosome aberrations in a sample of the population in the study and control areas was also investigated. The observations support the view that radiation induces genetic anomalies occur with above average frequency in the population living in the area with high background radiation. Only gross abnormalities evident in clinical examination were recorded. The study and control populations were similar in age and sex structure and general sociologic conditions. Severe mental retardation was the commonest abnormality encountered, and 85% of the abnormalities detected in the study population were genetic in origin, compared with 56% in the control population. Prevalence of Down's syndrome was 0.93 per 1000 in the study population. (U.K.)

Epidemiological studies on disturbances of human fetal development in areas with various doses of natural background radiation. I. Relationship between incidences of Down's syndrome or visible malformation and gonad dose equivalent rate of natural background radiation

International Nuclear Information System (INIS)

Ujeno, Y.

1985-01-01

The relationship between environmental radiation to the gonads and incidences of Down's syndrome and visible malformation was analyzed using Kendall's rank correlation method. The subjects, studied during a 3-yr period (1979-1981), were inhabitants of 46 prefectures in Japan that had various dose rates of natural background ionizing radiation. Results showed that the natural background very low-dose radiation rate was not a predominant factor responsible for inducing Down's syndrome or other visible malformations

Spacecraft radiator systems

Science.gov (United States)

Anderson, Grant A. (Inventor)

2012-01-01

A spacecraft radiator system designed to provide structural support to the spacecraft. Structural support is provided by the geometric "crescent" form of the panels of the spacecraft radiator. This integration of radiator and structural support provides spacecraft with a semi-monocoque design.

The influence of the microbial factor on the death of animals by intestinal radiation syndrome

International Nuclear Information System (INIS)

Kudryavtsev, V.D.; Kartasheva, A.L.; Tsyran, N.I.

1979-01-01

Data obtained in rats and mice irradiated with 900 - 1600 rad 60 Co gamma radiation point to an important role of the microbial factor in the 'intestinal death'. At the climax of the intestinal syndrome dysbacterial conditions developed violently in the intestinal content under predominance of putrefactive bacteria (Proteus). The application of kanamycin according to an elaborated pattern completely suppressed the proteus growth in the intestine and decreased considerably the content of obligatory representatives of the intestinal flora by which most of the animals could survive the time of 'intestinal death' (3rd to 5th day) after irradiation with relatively low doses (900 - 1200 rad). With increasing radiation doses (up to 1400 rad and more) the antibacterial therapy became uneffective because of the increasing importance of other lethal factors. The analysis of these results as well as literature data allow the conclusion that microbial intoxication plays a leading role in the death of the animals at the initial period and at the climax of the intestinal syndrome (3rd to 4th day). At the final stage of the development of the intestinal syndrome (5th day) septicaemia supervened. (author)

Medical Management of Acute Radiation Syndromes : Comparison of Antiradiation Vaccine and Antioxidants radioprotection potency.

Science.gov (United States)

Maliev, Slava; Popov, Dmitri; Lisenkov, Nikolai

Introduction: This experimental study of biological effects of the Antiradiation Vaccine and Antioxidants which were used for prophylaxis and treatment of the Acute Radiation Syndromes caused by high doses of the low-LET radiation. An important role of Reactive Oxyden Species (Singlet oxygen, hydroxyl radicals, superoxide anions and bio-radicals)in development of the Acute Radiation Syndromes could be defined as a "central dogma" of radiobiology. Oxida-tion and damages of lipids, proteins, DNA, and RNA are playing active role in development of postradiation apoptosis. However, the therapeutic role of antioxidants in modification of a postradiation injury caused by high doses of radiation remains controversial.Previous stud-ies had revealed that antioxidants did not increase a survival rate of mammals with severe forms of the Acute Radiation Syndromes caused by High Doses of the low-LET radiation. The Antiradiation Vaccine(ARV) contains toxoid forms of the Radiation Toxins(RT) from the Specific Radiation Determinants Group (SRD). The RT SRD has toxic and antigenic prop-erties at the same time and stimulates a specific antibody elaboration and humoral response form activated acquired immune system. The blocking antiradiation antibodies induce an im-munologically specific effect and have inhibiting effects on radiation induced neuro-toxicity, vascular-toxicity, gastrointestinal toxcity, hematopoietic toxicity, and radiation induced cytol-ysis of selected groups of cells that are sensitive to radiation. Methods and materials: Scheme of experiments: 1. Irradiated animals with development of Cerebrovascular ARS (Cv-ARS), Cardiovascular ARS (Cr-ARS) Gastrointestinal ARS(GI-ARS), Hematopoietic ARS (H-ARS) -control -were treated with placebo administration. 2. Irradiated animals were treated with antioxidants prophylaxisis and treatment of Cv-ARS, Cr-SRS, GI-ARS, Hp-ARS forms of the ARS. 3. irradiated animals were treated with radioprotection by Antiradiation Vaccine

Potential biological indicators of multi-organ damage: Application to radiation accident victims

International Nuclear Information System (INIS)

Bertho, J.M.; Souidi, M.; Gourmelon, P.

2009-01-01

Accidental irradiations induce a complex pathological situation, difficult to assess and to treat. However, recent results describing new biological indicators of radiation-induced damages such as Flt3-ligand, citrulline and oxy-sterol concentration in the plasma, together with results obtained in large animal models of high dose irradiation, allowed a better understanding of pathophysiological mechanisms induced by uncontrolled irradiations. This conducted to leave the classical paradigm of the acute radiation syndrome, described as the association of three individual syndromes, the hematopoietic syndrome, the gastro-intestinal syndrome and the cerebrovascular syndrome, in favour of a multiple organ dysfunction syndrome, with the implication of other organs and systems. Follow-up of victims from two recent radiation accidents brings a confirmation of the usefulness of the newly described biological indicators, and also a partial confirmation of this new concept of a multiple organ dysfunction syndrome. (authors)

Atomic bomb injury: radiation

Energy Technology Data Exchange (ETDEWEB)

Dunham, C L; Cronkite, E P; Le Roy, G V; Warren, S

1959-01-01

This document contains 3 reports. In the first report, the clinical diagnosis and treatment of radiation syndrome in survivors of the atomic explosions in Hiroshima and Nagasaki are described. The syndrome of acute radiation injury is applied to the symptom complex, or diseased state, which results from exposure of the whole body to the initial nuclear radiation of an atomic bomb. It is applied to injuries of the skin and subcutaneous tissues resulting from x-radiation or from contact with radioactive material. Internal radiation injury may result from the selective deposition, such as in bone or thyroid, of radioactive material that has been inhaled or absorbed through the gastrointestinal tract or wounds. Radiation syndrome is classified as very severe, severe, and mild. In the second report, a brief discussion is presented on the question of genetic effects in atomic bomb survivors in Hiroshima and Nagasaki. In the third report, a study was carried out on 205 4-1/2 year old children who had been exposed to the atomic bomb blast during the first half of intra-uterine life. Correlation between head size and mental development of the child with distance from the hypocenter, symptoms of radiation effect and type of shielding of the mother is discussed. The conclusion drawn from the present study is that central nervous system defects can be produced in the fetus by atomic bomb radiation, provided that exposure occurs within approximately 1200 meters of the hypocenter and that no effective shielding, such as concrete, protects the fetus from direct irradiation.

Normal formation and repair of γ-radiation-induced single and double strand DNA breaks in Down syndrome fibroblasts

International Nuclear Information System (INIS)

Steiner, M.E.; Woods, W.G.

1982-01-01

Fibroblasts from patients with Down syndrome (Trisomy 21) were examined for repair capability of γ-radiation-induced single strand and double strand DNA breaks. Formation and repair of DNA breaks were determined by DNA alkaline and non-denaturing elution techniques. Down syndrome fibroblasts were found to repair single strand and double strand breaks as well as fibroblasts from normal controls. (orig.)

Acute Radiation Syndrome. Consequences and outcomes

International Nuclear Information System (INIS)

Okladnikova, N.D.; Pesternikova, V.S.; Sumina, M.V.; Azizova, T.V.; Yurkov, N.N.

2000-01-01

The consequences and outcomes of an Acute Radiation Syndrome (ARS), induced by external gamma radiation for 59 persons (49 men and 10 women) have been estimated. All incidents have taken place more than 40 years ago in the yearly years of adjustment of an atomic industry (1950-1953-38 persons, 1954-1958-21 persons). According to the degree of severity ARS 5 groups are selected: the severest degree - 7 individuals (average dose in group 43.8±12.8 Sv), severe - 4 individuals (9.3±1.5 Sv), medium - 14 individuals (2.2±0.8 Sv), a light degree - 15 individuals (0.93±0.13 Sv), ''erased'' from - 19 individuals (0.85±0.07 Sv). In all cases, except for lethal (the severest degree), the characteristics of morphological composition of the peripheral blood were restored in the first year after ARS and now correspond to physiological standard. In 2 cases the moderate hypoplasia of granulocytopoiesis was diagnosed. A marker of the acute exposure was the chromosome aberrations in lymphocytes of the peripheral blood. The frequency of chromosome aberrations correlates with severity degree of ARS (from 3-7 up to 35-50 stable aberrations per 100 cells). In cases of ARS with severe degree the early development of a cerebral atherosclerosis is detected. The radiation cataract was diagnosed in 5 patients (an exposure doses 4.0-9.8 Sv, a period of development 2-5 years). During the first years after ARS in 80% of cases the complete labour rehabilitation is reached. Of 53 patients with known vital status by 45 year of monitoring 19 persons (35.8%) have died, of these in 2 cases the causes of death are not determined. In remaining cases the causes of death were ARS of severest degree (7 persons), Ischemic Heart Disease (5 persons), malignant tumors (4 persons), accidents and traumas (2 persons). (author)

Protracted Oxidative Alterations in the Mechanism of Hematopoietic Acute Radiation Syndrome

Directory of Open Access Journals (Sweden)

Nikolai V. Gorbunov

2015-02-01

Full Text Available The biological effects of high-dose total body ionizing irradiation [(thereafter, irradiation (IR] are attributed to primary oxidative breakage of biomolecule targets, mitotic, apoptotic and necrotic cell death in the dose-limiting tissues, clastogenic and epigenetic effects, and cascades of functional and reactive responses leading to radiation sickness defined as the acute radiation syndrome (ARS. The range of remaining and protracted injuries at any given radiation dose as well as the dynamics of post-IR alterations is tissue-specific. Therefore, functional integrity of the homeostatic tissue barriers may decline gradually within weeks in the post-IR period culminating with sepsis and failure of organs and systems. Multiple organ failure (MOF leading to moribundity is a common sequela of the hemotapoietic form of ARS (hARS. Onset of MOF in hARS can be presented as “two-hit phenomenon” where the “first hit” is the underlying consequences of the IR-induced radiolysis in cells and biofluids, non-septic inflammation, metabolic up-regulation of pro-oxidative metabolic reactions, suppression of the radiosensitive hematopoietic and lymphoid tissues and the damage to gut mucosa and vascular endothelium. While the “second hit” derives from bacterial translocation and spread of the bacterial pathogens and inflammagens through the vascular system leading to septic inflammatory, metabolic responses and a cascade of redox pro-oxidative and adaptive reactions. This sequence of events can create a ground for development of prolonged metabolic, inflammatory, oxidative, nitrative, and carbonyl, electrophilic stress in crucial tissues and thus exacerbate the hARS outcomes. With this perspective, the redox mechanisms, which can mediate the IR-induced protracted oxidative post-translational modification of proteins, oxidation of lipids and carbohydrates and their countermeasures in hARS are subjects of the current review. Potential role of ubiquitous

Down syndrome and the high background radiation areas of Kerala

International Nuclear Information System (INIS)

Jaikrishan, G.; Ramachandran, E.N.; Karuppasamy, C.V.; Sudheer, K.R.; Andrews, V.J.; Soren, D.C.; Anil Kumar, V.; Koya, P.K.M.; Cheriyan, V.D.; Seshadri, M.

2010-01-01

Down syndrome (DS) or trisomy-21 is a complex human clinical entity compromising several functional, structural and developmental features with wide variation in expression levels. The diagnosis is confirmed in majority of the cases by an extra dose of chromosome 21 by cytogenetics and occasionally it may be due to either chromosomal translocation or mosaicism (different cell lines in the same individual). The extra chromosome 21 is usually formed by non-disjunction during meiosis and is the most common numerical chromosomal anomaly compatible with life, as chromosome 21 is one of the smallest with relatively fewer genes most of which are reckoned to be non lethal. Though exact causative factors and pathogenesis is not fully understood, a rise in maternal age at conception coupled with deleterious environmental influence on an ageing ovum is a recognized risk factor. The de novo nature of trisomy-21 and its relatively higher frequency makes it a reliable indicator to assess the role of chronic high background radiation in inducing germ line mutation and congenital malformation. Many other relatively common congenital malformations with multifactorial origin may not have this de novo property and associating its incidence with the prevailing natural background radiation become more complex. In vitro studies have shown association between high intensity radiation and genetics effects but such a relationship so far was not established between DS and radiation

High Frequency of AML1/RUNX1 Point Mutations in Radiation-Associated Myelodysplastic Syndrome Around Semipalatinsk Nuclear Test Site

OpenAIRE

Dinara, ZHARLYGANOVA; Hironori, HARADA; Yuka, HARADA; Sergey, SHINKAREV; Zhaxybay, ZHUMADILOV; Aigul, ZHUNUSOVA; Naylya J., TCHAIZHUNUSOVA; Kazbek N., APSALIKOV; Vadim, KEMAIKIN; Kassym, ZHUMADILOV; Noriyuki, KAWANO; Akiro, KIMURA; Masaharu, HOSHI; Department of Radiation Biophysics, Research Institute for Radiation Biology and Medicine, Hiroshima University; Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University

2008-01-01

It is known that bone marrow is a sensitive organ to ionizing radiation, and many patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) have been diagnosed in radiation-treated cases and atomic bomb survivors in Hiroshima and Nagasaki. The AML1/RUNX1 gene has been known to be frequently mutated in MDS/AML patients among atomic bomb survivors and radiation therapy-related MDS/AML patients. In this study, we investigated the AML1 mutations in radiation-exposed patients wi...

Counterbalanced radiation detection system

International Nuclear Information System (INIS)

Platz, W.

1987-01-01

A counterbalanced radiation detection system is described comprising: (a) a stand; (b) a first radiation detector; (c) a first radiation detector arm means for tiltably connecting the first radiation detector with the stand; (d) a second radiation detector; (e) a second radiation detector arm means for tiltably connecting the second radiation detector with the stand, whereby the tilting angles of the radiation detector arm means define a distance between the radiation detectors; and (f) a torque transforming means connected between the first and second radiation detector arm means for transforming the torque created by one of the radiation detectors in a sense opposed to the torque created by the other radiation detector

Sjogrens Syndrome Presenting with Central Nervous System Involvement

Directory of Open Access Journals (Sweden)

Tülay Terzi

2012-01-01

Full Text Available Sjogren’s syndrome is a slowly progressive autoimmune disease. Neurological involvement occurs in approximately 20-25% cases in Sjogren’s syndrome. 87% of the neurological involvement is peripheral nervous system, almost 13% in the form of central nervous system involvement. Affected central nervous system may show similar clinical and radiological findings as in multiple sclerosis (MS. In this paper, a 43-year-old patient is discussed who was referred with the complaint of dizziness, there was MS- like lesions in brain imaging studies and was diagnosed with Sjogren’s syndrome. MS- like clinical and radiologic tables can be seen, albeit rarely in Sjogren’s syndrome. In these cases, early diagnosis and early treatment for the sjögren has a great importance for the prognosis of the disease.

Computer-controlled radiation monitoring system

International Nuclear Information System (INIS)

Homann, S.G.

1994-01-01

A computer-controlled radiation monitoring system was designed and installed at the Lawrence Livermore National Laboratory's Multiuser Tandem Laboratory (10 MV tandem accelerator from High Voltage Engineering Corporation). The system continuously monitors the photon and neutron radiation environment associated with the facility and automatically suspends accelerator operation if preset radiation levels are exceeded. The system has proved reliable real-time radiation monitoring over the past five years, and has been a valuable tool for maintaining personnel exposure as low as reasonably achievable

A multi-centre clinical follow-up database as a systematic approach to the evaluation of mid- and long-term health consequences in Chernobyl acute radiation syndrome patients

International Nuclear Information System (INIS)

Fischer, B.; Weiss, M.; Fliedner, T.M.; Belyi, D.A.; Kovalenko, A.N.; Bebeshko, V.G.; Nadejina, N.M.; Galstian, I.A.

1996-01-01

This paper describes scope, design and first results of a multi-centre follow-up database that has been established for the evaluation of mid- and long-term health consequences of acute radiation syndrome (ARS) survivors. After the Chernobyl accident on 26 April 1986, 237 cases with suspected acute radiation syndrome have been reported. For 134 of these cases the diagnosis of ARS was confirmed in a consensus conference three years after the accident. Nearly all survivors underwent regular follow-up examinations in two specialized centres in Kiev and in Moscow. In collaboration with these centres we established a multi-centre clinical follow-up database that records the results of the follow-up examinations in a standardized schema. This database is an integral part of a five step approach to patient evaluation and aims at a comprehensive base for scientific analysis of the mid- and long-term consequences of accidental ionizing radiation. It will allow for a dynamic view on the development of the health status of individuals and groups of patients as well as the identification of critical organ systems that need early support, and an improvement of acute and follow-up treatment protocols for radiation accident victims

Treatment and follow-up of patients suffering from the cutaneous radiation syndrome

International Nuclear Information System (INIS)

Peter, R.U.; Gottloeber, P.; Heckmann, M.; Braun-FaIco, O.; Plewig, G.

1996-01-01

The hazards of acute radiation exposure are commonly addressed with respect to total body gamma or neutron irradiation, resulting primarily in bone marrow failure as the main clinically relevant aspect of the acute radiation disease. Under conditions of inhomogeneous exposure, as they are characteristic for many accident scenarios, other organ systems, such as the skin may become more important in determining clinical prognosis. This became especially obvious in the two worst radiation accidents since 1945, the Chernobyl accident in April 1986 and the Goiania accident in September 1987. The characteristic chronic sequelae of accidental cutaneous radiation exposure and therapeutic results have been described based on own clinical experience with treating patients with acute and late cutaneous effects after therapeutic irradiation, and a distinct group of patients having survived the Chernobyl nuclear power plant accident of April 26, 1986. Apart from clinical examination, histological analysis and high-frequency (20 MHz) ultrasound as well as a variety of functional tests have been used to determine the extent of radiation fibrosis and to exclude malignant transformation of keratoses and ulcers. Treatment included, apart from dermatosurgical procedures and plastic surgery for disabling contractures or ulcers, argon laser treatment of telangiectasias, topical tretinoin 0,005% (Epi-Aberel R , Cilag, Frankfurt), etretinate and acitretin (Tigason R , Neotigason R , Hoffmann LaRoche, Grenzach) for radiation keratoses, partly combined with a novel, nonatrophogenic steroid, Mometasonefuroate (Elocon R , Schering-Plough, New Jersey) to antagonize inflammatory reactions, and low-dose interferon-gamma (Polyferon R , Rentschler, Laupheim) for extensive radiation fibrosis. Basic dermatotherapy was performed with an ointment containing linoleic acid (Linola R , Wolff, Bielefeld). With this combination treatment, transepidermal water loss could be sustained, progression of

Debris prevention system, radiation system, and lithograpic apparatus

NARCIS (Netherlands)

2009-01-01

A debris prevention system is constructed and arranged to prevent debris that emanates from a radiation source from propagating with radiation from the radiation source into or within a lithographic apparatus. The debris prevention system includes an aperture that defines a maximum emission angle of

Deficiencies in radiation protection record systems

International Nuclear Information System (INIS)

Martin, J.B.; Lyon, M.

1991-01-01

Radiation protection records are a fundamental part of any program for protecting radiation workers. Records are essential to epidemiological studies of radiation workers and are becoming increasingly important as the number of radiation exposure litigation cases increases. Ready retrievability of comprehensive records is also essential to the adequate defense of a radiation protection program. Appraisals of numerous radiation protection programs have revealed that few record-keeping systems comply with American National Standards Institute, Standard Practice N13.6-1972. Record-keeping requirements and types of deficiencies in radiation protection records systems are presented in this paper, followed by general recommendations for implementing a comprehensive radiation protection records system

Deficiencies in radiation protection record systems

International Nuclear Information System (INIS)

Martin, J.B.; Lyon, M.

1991-01-01

Radiation protection records are a fundamental part of any program for protecting radiation workers. Records are essential to epidemiological studies of radiation workers and are becoming increasingly important as the number of radiation exposure litigation cases increases. Ready retrievability of comprehensive records is also essential to the adequate defense of a radiation protection program. Appraisals of numerous radiation protection programs have revealed that few record-keeping systems comply with American National Standards Institute, Standard Practice N13.6-1972. Record-keeping requirements and types of deficiencies in radiation protection records systems are presented in this paper, followed by general recommendations for implementing a comprehensive radiation protection records system. 8 refs

Radiation injury to the nervous system

International Nuclear Information System (INIS)

Gutin, P.H.; Leibel, S.A.; Sneline, G.E.

1991-01-01

This book is designed to describe to the radiation biologist, radiation oncologist, neurologist, neurosurgeon, medical oncologist, and neuro-oncologist, the current state of knowledge about the tolerance of the nervous system to various kinds of radiation, the mechanisms of radiation injury, and how nervous system tolerance and injury are related to the more general problem of radiation damage to normal tissue of all types. The information collected here should stimulate interest in and facilitate the growing research effort into radiation injury to the nervous system

Chronic recurrent Gorham-Stout syndrome with cutaneous involvement

Directory of Open Access Journals (Sweden)

Nahum Duker

2010-09-01

Full Text Available Type IV osteolysis or Gorham-Stout syndrome is a rare condition characterized by recurrent vascular tumors that disrupt normal anatomical architecture. Gorham-Stout syndrome is most commonly associated with the skeletal system with resulting replacement of bone with scar tissue following tumor regression. The loss of entire bones has given Gorham-Stout syndrome the moniker vanishing bone disease. Natural progression of Gorham-Stout syndrome is characterized by spontaneous disease resolution. However, rare variants of recurrent, progressive, and/or systemic disease have been reported. We present a patient with a history of recurrent Gorham-Stout disease refractory to all treatment options considered. In addition to skeletal disease, our patient had soft tissue and cutaneous involvement, thus reflecting the more aggressive disease variant. Previous surgical attempts to control disease had been ineffective and the patient was referred to us for radiation therapy. Treatment with external beam radiation therapy resulted in good local control and symptom palliation, but full disease resolution was never accomplished. In addition to presentation of this patient, a review of the literature on etiological hypotheses and past/future treatment options was conducted and is included.

[On establishing comparative reference system for syndrome classification study from the thinking characteristics of syndrome differentiation dependent therapy].

Science.gov (United States)

Liu, Ping; Hu, Yi-yang; Ni, Li-qiang

2006-05-01

To create a comparative referential system for syndrome classification study by viewing from the thinking characteristics of TCM on syndrome differentiation dependent therapy (SDDT), through analyzing the thinking process of SDDT, and the basic features of disease, syndrome and prescription, combining the basic principles of modern evidence-based medicine and feasibility of establishing integrative disease-syndrome animal model. The practice of creating a comparative referential system based on clinical efficacy of prescription was discussed around syndrome pathogenesis and its relationship with disease and prescription, which was one of the important scientific problems in TCM syndrome study. The authors hold that, it may be one of the available approaches for the present study on integration of disease with syndrome by way of insisting on the thinking pathway of stressing the characteristics of TCM and intermerging with modern scientific design; on taking the efficacy of prescription as the comparative reference system to accumulate and improve unceasingly according to the TCM method of syndrome diagnosis inferred from effect of prescription with reverse thought (i.e., to differentiate syndrome from the effect of prescription), and thus build up the syndrome diagnostic standard on the solid clinical and scientific base.

Medical response to radiation emergencies in Argentina

International Nuclear Information System (INIS)

Gisone, Pablo A.; Perez, Maria del R.; Dubner, Diana L.; Michelin, Severino C.; Vazquez, M.; Demayo, O.

2006-01-01

Although radiation accidents are not frequent, the increasing use of radioisotopes in medicine and industry increases the likelihood of such accidental situations. Additionally, risks posed by the malevolent use of radiation sources have been highlighted during the last few years. In this context, the enhancement of national capabilities for medical assistance of victims in radiation emergencies becomes relevant. This communication describes the organization of medical response to radiation emergencies existing in Argentina. A three-level system for medical response has been developed: pre-hospital response given on-site by local emergency services, assistance provided by emergency departments of local general hospitals and central reference hospitals for treatment of acute radiation syndrome, cutaneous radiation syndrome and internal contamination. An education and training program is regularly executed at the three levels, including theoretical background as well as practical training. Guidelines and protocols for medical handling of victims have been elaborated and implemented. Research and development of new strategies for diagnosis and treatment of radiation injuries are promoted by ARN in close collaboration with physicians belonging to reference hospitals. (author)

Radiation-resistant control system

International Nuclear Information System (INIS)

Cable, T.C.; Jones, S.

1995-01-01

REMOTEC has developed a open-quotes radiation resistanceclose quotes control system under a U.S. Department of Energy Small Business Innovative Research (SBIR) contract with assistance from the University of Florida. The SBIR goal was to develop a radiation resistant mobile robot from the ANDROS family of hazardous duty mobile robots that REMOTEC manufactures. See Refs. 1 and 2 for additional SBIR results. The control system, as well as the entire ANDROS robot, was redesigned, where necessary, to withstand radiation doses in excess of 10 6 rad. Those components of the robot that could not be purchased as open-quotes radiation hardenedclose quotes were tested under standard operating conditions for determination of their open-quotes radiation resistance.close quotes The entire ANDROS robot was then assembled with these new components and tested to > 10 6 rad

Sweet syndrome revealing systemic lupus erythematosus.

LENUS (Irish Health Repository)

Quinn, N

2015-02-01

Sweet Syndrome is an acute inflammatory skin eruption which is rare in children. We report a case of childhood Systemic Lupus Erythematosus (SLE) that presented with Sweet syndrome. This case is a unique presentation of a common disorder which provides a new facet for the differential diagnosis of SLE in children. It is also the first paediatric case to be reported in a Caucasian child.

Elevated systemic galectin-1 levels characterize HELLP syndrome.

Science.gov (United States)

Schnabel, Annegret; Blois, Sandra M; Meint, Peter; Freitag, Nancy; Ernst, Wolfgang; Barrientos, Gabriela; Conrad, Melanie L; Rose, Matthias; Seelbach-Göbel, Birgit

2016-04-01

Galectin-1 (gal-1), a member of a family of conserved β-galactoside-binding proteins, has been shown to exert a key role during gestation. Though gal-1 is expressed at higher levels in the placenta from HELLP patients, it is still poorly understood whether systemic gal-1 levels also differ in HELLP patients. In the present study, we evaluated the systemic expression of gal-1, together with the angiogenic factors, placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt-1) in conjunction with HELLP syndrome severity. Systemic levels of gal-1 and sFlt-1 were elevated in patients with both early- and late-onset HELLP syndrome as compared to healthy controls. In contrast, peripheral PlGF levels were decreased in early- and late-onset HELLP. A positive correlation between systemic gal-1 levels and sFlt-1/PlGF ratios was found in early onset HELLP patients. Our results show that HELLP syndrome is associated with increased circulating levels of gal-1; integrating systemic gal-1 measurements into the diagnostic analyses of pregnant women may provide more effective prediction of HELLP syndrome development. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Limbic system, the main focus of dementia syndrome

International Nuclear Information System (INIS)

Matsuzawa, Taiju

1990-01-01

Alzheimer disease and multi-infarct dementia are two entirely different diseases producing almost the same abnormalities as dementia syndrome. The statistical studies with MRI to locate the focus of dementia syndrome in the neocortex was an absolute failure. With MRI there is drastic atrophy and destruction of the amygdala and hippocampus suggesting the limbic system as the focus of dementia syndrome. Destruction of the limbic system in particular amygdala and hippocampus produced the functional obstruction brought about by the marked reduction in the glucose utilization with PET in the bilateral temporal, parietal and occipital association cortices. Although this type constitutes only about 1/5 of all dementia patients. It is considered the fundamental type of dementia syndrome. Aside from this, there is a type wherein simultaneous and symmetrical reductions in glucose utilization of the frontal association cortex and the motor association cortex in the anterior part of the neocortex. This is referred to as type II. It constitutes about 4/5 of all dementia patients which is far more than type I. Based on these results, it is thought that limbic system is the main focus of dementia syndrome. (author)

Maintenance of radiation monitoring systems

International Nuclear Information System (INIS)

Aoyama, Kei

2001-01-01

As the safety and quality of atomic power facilities are more strongly required, the reliability improvement and preventive maintenance of radiation monitoring systems are important. This paper describes the maintenance of radiation monitoring systems delivered by Fuji Electric and the present status of preventive maintenance technology. Also it introduces the case that we developed a fault diagnosis function adopting a statistics technique and artificial intelligence (AI) and delivered a radiation monitoring system including this function. This system can output a fault analysis result and a countermeasure from the computer in real time. (author)

A system of dose-effects relationships for the Northern wildlife: radiation protection criteria

International Nuclear Information System (INIS)

Sazykina, T.G.

2004-01-01

The key issue in the assessment system for radiation protection of wildlife is the establishment of a set of dose-effects relationships for reference representatives of natural biota, based on scientific data from a range of doses and a range of radiation effects. Risks to natural populations in particular habitats can be evaluated from a comparison of estimated doses to biota with the scale of dose-effects relationships for different types of biota. Within the frame of the EC Project EPIC 'Environmental Protection from Ionizing Contaminants' 2000-2003), a database has been created, which include the published and unpublished data relating to dose effects relationships for flora and fauna in the Northern and Arctic areas. The EPIC database contains information based exclusively on Russian/FSU experimental and field studies; chronic/lifetime exposures were the focus of the work, owing to the fact that such exposures are the most typical in radiological assessments for biota. In total, the EPIC database radiation effects on biota contains about 1600 records from 440 publications, including datasets on terrestrial and aquatic animals, plants, soil fauna and microorganisms. The EPIC database information cover a very wide range of radiation dose rates to wild flora and fauna: from below 10 -5 Gy d -1 up to more than 1 Gy d -1 . A great variety of radiation effects are registered in the EPIC database, from stimulation at low doses up to death from acute radiation syndrome at high doses. From data, compiled in the EPIC database, the dose-effects relationships were derived for different types of northern organisms. The system of dose-effects relationships forms the scale of severity of radiation effects at increasing levels of chronic radiation exposure. With its focus on the effects of low-to-moderate chronic exposure, the system of dose effects relationships provides a useful tool for scientists and decision-makers to establish safety standards for protecting the

Study of national registration systems for health records of radiation workers. National radiation dose registration system

International Nuclear Information System (INIS)

Nakagawa, Haruo; Kanda, Keiji

1999-01-01

A national radiation dose registration system is proposed in this paper. In Japan, only one radiation dose registration system is partly effective. It is applied for workers in nuclear power plants which are under control of regulatory laws for nuclear reactors. The total system was proposed previously by the Committee for Compensation Claims of Nuclear Accidents. The reason for the delay in establishing a registration system for all radiation workers is supposedly a lack of effort to adjust differences among items in radiation protection laws and the promotion of public acceptance to atomic power. Items about dose recordings, record keeping and dose-record reporting in all of the radiation regulatory laws are compared to each other, and items were extracted for revision. (author)

Hereditary syndromes with enhanced radiosensitivity

International Nuclear Information System (INIS)

Lohmann, D.

2000-01-01

Sensitivity to ionizing radiation is modified by heritable genetic factors. This is exemplified by heritable disorders that are characterized by predisposition to the development of neoplasms. Cells derived from patients with ataxia telangiectasia, Nijmegen breakage syndrome and ataxia telangiektasia-like disorder show a markedly changed reaction to exposure to ionizing radiation. Correspondingly, at least in patients with ataxia telangiectasia, an enhanced radiosensitivity that is of clinical importance has been observed. In addition to these recessive disorders, some autosomal dominant cancer predisposition syndromes are associated with increased radiosensitivity. As cells from these patients still have a normal allele (that is dominant over the mutant allele), the cellular phenotype is most often normal. Specifically, there is no overtly altered reaction in response to ionizing radiation. Nevertheless, two dominant cancer predisposition syndromes, namely hereditary retinoblastoma and naevoid basal cell carcinoma syndrome, are associated with a enhanced radiosensitivity as indicated by increased development of tumors following radiation therapy. (orig.) [de

ERMS - Environmental Radiation Monitoring System

International Nuclear Information System (INIS)

Vax, Eran; Sarusi, Benny; Sheinfeld, Mati; Levinson, Shmuel; Brandys, Irad; Sattinger, Danny; Wengrowicz, Udi; Tshuva, Avi; Tirosh, Dan

2008-01-01

A new Environmental Radiation Monitoring System (ERMS) has been developed in the NRCN as an extensive tool to be applied in case of nuclear malfunction or Nuclear Disposal Device (NDD) incident, as well as for routine radiation monitoring of the reactor's vicinity. The system collects real-time environmental data such as: gamma radiation, wind speed, wind direction, and temperature for monitoring purposes. The ERMS consists of a main Control Center and an array of monitoring stations. Fixed, environmental, gamma radiation monitoring stations are installed at the reactor's surroundings while portable stations can be posted rapidly along the wind direction, enhancing the spatial sampling of the radiation measurements and providing better hazard assessment at an emergency event. The presented ERMS, based on industrial standards for hardware and network protocols, is a reliable standalone system which upgrades the readiness to face a nuclear emergency event by supplying real-time, integrated meteorological and radiation data. (author)

Randomized comparison of operator radiation exposure comparing transradial and transfemoral approach for percutaneous coronary procedures: rationale and design of the minimizing adverse haemorrhagic events by TRansradial access site and systemic implementation of angioX - RAdiation Dose study (RAD-MATRIX).

Science.gov (United States)

Sciahbasi, Alessandro; Calabrò, Paolo; Sarandrea, Alessandro; Rigattieri, Stefano; Tomassini, Francesco; Sardella, Gennaro; Zavalloni, Dennis; Cortese, Bernardo; Limbruno, Ugo; Tebaldi, Matteo; Gagnor, Andrea; Rubartelli, Paolo; Zingarelli, Antonio; Valgimigli, Marco

2014-06-01

Radiation absorbed by interventional cardiologists is a frequently under-evaluated important issue. Aim is to compare radiation dose absorbed by interventional cardiologists during percutaneous coronary procedures for acute coronary syndromes comparing transradial and transfemoral access. The randomized multicentre MATRIX (Minimizing Adverse Haemorrhagic Events by TRansradial Access Site and Systemic Implementation of angioX) trial has been designed to compare the clinical outcome of patients with acute coronary syndromes treated invasively according to the access site (transfemoral vs. transradial) and to the anticoagulant therapy (bivalirudin vs. heparin). Selected experienced interventional cardiologists involved in this study have been equipped with dedicated thermoluminescent dosimeters to evaluate the radiation dose absorbed during transfemoral or right transradial or left transradial access. For each access we evaluate the radiation dose absorbed at wrist, at thorax and at eye level. Consequently the operator is equipped with three sets (transfemoral, right transradial or left transradial access) of three different dosimeters (wrist, thorax and eye dosimeter). Primary end-point of the study is the procedural radiation dose absorbed by operators at thorax. An important secondary end-point is the procedural radiation dose absorbed by operators comparing the right or left radial approach. Patient randomization is performed according to the MATRIX protocol for the femoral or radial approach. A further randomization for the radial approach is performed to compare right and left transradial access. The RAD-MATRIX study will probably consent to clarify the radiation issue for interventional cardiologist comparing transradial and transfemoral access in the setting of acute coronary syndromes. Copyright © 2014 Elsevier Inc. All rights reserved.

Passive-solar directional-radiating cooling system

Science.gov (United States)

Hull, J.R.; Schertz, W.W.

1985-06-27

A radiative cooling system for use with an ice-making system having a radiating surface aimed at the sky for radiating energy at one or more wavelength bands for which the atmosphere is transparent and a cover thermally isolated from the radiating surface and transparent at least to the selected wavelength or wavelengths, the thermal isolation reducing the formation of condensation on the radiating surface and/or cover and permitting the radiation to continue when the radiating surface is below the dewpoint of the atmosphere, and a housing supporting the radiating surface, cover and heat transfer means to an ice storage reservoir.

Radiation sensitivity of fibroblast strains from patients with Usher's syndrome, Duchenne muscular dystrophy, and Huntington's disease

International Nuclear Information System (INIS)

Nove, J.; Little, J.B.; Tarone, R.E.; Robbins, J.H.

1987-01-01

The colony-forming ability of 10 normal human fibroblast cell strains and of 10 strains representing 3 degenerative diseases of either nerve or muscle cells was determined after exposure of the cells to X-rays or β-particles from tritiated water. Both methods of irradiation yielded similar comparative results. The fibroblast strains from the 5 Usher's syndrome patients and from 1 of the 2 Huntington's disease patients were hypersensitive to radiation, while those from the 3 Duchenne muscular dystrophy patients and the second Huntington's disease patient had normal sensitivity to radiation. These results indicate both disease-specific and strain-specific differences in the survival of fibroblasts after exposure to ionizing radiation. 38 refs.; 2 figs.; 3 tabs

Radiation effects on living systems

International Nuclear Information System (INIS)

Hawley, N.J.

1980-10-01

This bibliography includes papers and reports by Atomic Energy of Canada Limited scientists concerning radiation effects on living systems. It is divided into three sections: Radiobiology, Radiation Biochemistry and Radiation Chemistry. (auth)

Versatile radiation gaging system

International Nuclear Information System (INIS)

Long, P.J.

1978-01-01

The attributes of computerized versatile radiation gaging systems are described. The gages are used to measure plating thicknesses and material characteristics that can be determined from radiation attenuation and/or x-ray fluorescence measurements

Randomized comparison of operator radiation exposure comparing transradial and transfemoral approach for percutaneous coronary procedures: rationale and design of the minimizing adverse haemorrhagic events by TRansradial access site and systemic implementation of angioX – RAdiation Dose study (RAD-MATRIX)

International Nuclear Information System (INIS)

Sciahbasi, Alessandro; Calabrò, Paolo; Sarandrea, Alessandro; Rigattieri, Stefano; Tomassini, Francesco; Sardella, Gennaro; Zavalloni, Dennis; Cortese, Bernardo; Limbruno, Ugo; Tebaldi, Matteo; Gagnor, Andrea; Rubartelli, Paolo; Zingarelli, Antonio; Valgimigli, Marco

2014-01-01

Background: Radiation absorbed by interventional cardiologists is a frequently under-evaluated important issue. Aim is to compare radiation dose absorbed by interventional cardiologists during percutaneous coronary procedures for acute coronary syndromes comparing transradial and transfemoral access. Methods: The randomized multicentre MATRIX (Minimizing Adverse Haemorrhagic Events by TRansradial Access Site and Systemic Implementation of angioX) trial has been designed to compare the clinical outcome of patients with acute coronary syndromes treated invasively according to the access site (transfemoral vs. transradial) and to the anticoagulant therapy (bivalirudin vs. heparin). Selected experienced interventional cardiologists involved in this study have been equipped with dedicated thermoluminescent dosimeters to evaluate the radiation dose absorbed during transfemoral or right transradial or left transradial access. For each access we evaluate the radiation dose absorbed at wrist, at thorax and at eye level. Consequently the operator is equipped with three sets (transfemoral, right transradial or left transradial access) of three different dosimeters (wrist, thorax and eye dosimeter). Primary end-point of the study is the procedural radiation dose absorbed by operators at thorax. An important secondary end-point is the procedural radiation dose absorbed by operators comparing the right or left radial approach. Patient randomization is performed according to the MATRIX protocol for the femoral or radial approach. A further randomization for the radial approach is performed to compare right and left transradial access. Conclusions: The RAD-MATRIX study will probably consent to clarify the radiation issue for interventional cardiologist comparing transradial and transfemoral access in the setting of acute coronary syndromes

Randomized comparison of operator radiation exposure comparing transradial and transfemoral approach for percutaneous coronary procedures: rationale and design of the minimizing adverse haemorrhagic events by TRansradial access site and systemic implementation of angioX – RAdiation Dose study (RAD-MATRIX)

Energy Technology Data Exchange (ETDEWEB)

Sciahbasi, Alessandro, E-mail: alessandro.sciahbasi@fastwebnet.it [Interventional Cardiology, Sandro Pertini Hospital – ASL RMB, Rome (Italy); Calabrò, Paolo [Division of Cardiology - Department of Cardio-Thoracic Sciences - Second University of Naples (Italy); Sarandrea, Alessandro [HSE Management, Rome (Italy); Rigattieri, Stefano [Interventional Cardiology, Sandro Pertini Hospital – ASL RMB, Rome (Italy); Tomassini, Francesco [Department of Cardiology, Infermi Hospital, Rivoli (Italy); Sardella, Gennaro [La Sapienza University, Rome (Italy); Zavalloni, Dennis [UO Emodinamica e Cardiologia Invasiva, IRCCS, Istituto Clinico Humanitas, Rozzano (Italy); Cortese, Bernardo [Interventional Cardiology, Fatebenefratelli Hospital, Milan (Italy); Limbruno, Ugo [Cardiology Unit, Misericordia Hospital, Grosseto (Italy); Tebaldi, Matteo [Cardiology Department, University of Ferrara, Department of Cardiology (Italy); Gagnor, Andrea [Department of Cardiology, Infermi Hospital, Rivoli (Italy); Rubartelli, Paolo [Villa Scassi Hospital, Genova (Italy); Zingarelli, Antonio [San Martino Hospital, Genova (Italy); Valgimigli, Marco [Thoraxcenter, Rotterdam (Netherlands)

2014-06-15

Background: Radiation absorbed by interventional cardiologists is a frequently under-evaluated important issue. Aim is to compare radiation dose absorbed by interventional cardiologists during percutaneous coronary procedures for acute coronary syndromes comparing transradial and transfemoral access. Methods: The randomized multicentre MATRIX (Minimizing Adverse Haemorrhagic Events by TRansradial Access Site and Systemic Implementation of angioX) trial has been designed to compare the clinical outcome of patients with acute coronary syndromes treated invasively according to the access site (transfemoral vs. transradial) and to the anticoagulant therapy (bivalirudin vs. heparin). Selected experienced interventional cardiologists involved in this study have been equipped with dedicated thermoluminescent dosimeters to evaluate the radiation dose absorbed during transfemoral or right transradial or left transradial access. For each access we evaluate the radiation dose absorbed at wrist, at thorax and at eye level. Consequently the operator is equipped with three sets (transfemoral, right transradial or left transradial access) of three different dosimeters (wrist, thorax and eye dosimeter). Primary end-point of the study is the procedural radiation dose absorbed by operators at thorax. An important secondary end-point is the procedural radiation dose absorbed by operators comparing the right or left radial approach. Patient randomization is performed according to the MATRIX protocol for the femoral or radial approach. A further randomization for the radial approach is performed to compare right and left transradial access. Conclusions: The RAD-MATRIX study will probably consent to clarify the radiation issue for interventional cardiologist comparing transradial and transfemoral access in the setting of acute coronary syndromes.

Histiocytoid Sweet Syndrome in a Child without Underlying Systemic Disease.

Science.gov (United States)

Yeom, Seung Dohn; Ko, Hye Soo; Moon, Jong Hyuk; Kang, Min Ji; Byun, Ji Won; Choi, Gwang Seong; Shin, Jeonghyun

2017-10-01

Sweet syndrome (acute, febrile, neutrophilic dermatosis) is characterized by the acute onset of an eruption of painful nodules or erythematous or violaceous plaques on the limbs, face and neck. These symptoms are accompanied by fever. The diagnostic features include histopathological findings of dermal neutrophilic infiltration without leukocytoclastic vasculitis or peripheral blood leukocytosis. Sweet syndrome is associated with infection, malignancies, autoimmune disease, pregnancy, and drugs. Patients with Sweet syndrome demonstrate a complete and rapid response to systemic steroid administration. Recently, a distinct variant of Sweet syndrome was reported, termed "histiocytoid Sweet syndrome", in which the infiltration of myeloperoxidase-positive histiocytoid mononuclear cells are observed (in contrast to the infiltration of neutrophils). The other clinical features are similar to those of classic Sweet syndrome. Pediatric Sweet syndrome is uncommon, and the histiocytoid type is even rarer. To date, four cases of histiocytoid Sweet syndrome have been reported in children. Herein, we describe a case of histiocytoid Sweet syndrome in an otherwise healthy 10-year-old boy with no underlying systemic disease in whom non-steroidal, anti-inflammatory drug treatment was successful.

Dosimetry systems for radiation processing

International Nuclear Information System (INIS)

McLaughlin, W.L.; Desrosiers, M.F.

1995-01-01

Dosimetry serves important functions in radiation processing, where large absorbed doses and dose rates from photon and electron sources have to be measured with reasonable accuracy. Proven dosimetry systems are widely used to perform radiation measurements in development of new processes, validation, qualification and verification (quality control) of established processes and archival documentation of day-to-day and plant-to-plant processing uniformity. Proper calibration and traceability of routine dosimetry systems to standards are crucial to the success of many large-volume radiation processes. Recent innovations and advances in performance of systems that enhance radiation measurement assurance and process diagnostics include dose-mapping media (new radiochromic film and solutions), optical waveguide systems for food irradiation, solid-state devices for real-time and passive dosimetry over wide dose-rate and dose ranges, and improved analytical instruments and data acquisition. (author)

Radiation signal processing system

International Nuclear Information System (INIS)

Bennett, M.; Knoll, G.; Strange, D.

1980-01-01

An improved signal processing system for radiation imaging apparatus comprises: a radiation transducer producing transducer signals proportional to apparent spatial coordinates of detected radiation events; means for storing true spatial coordinates corresponding to a plurality of predetermined apparent spatial coordinates relative to selected detected radiation events said means for storing responsive to said transducer signal and producing an output signal representative of said true spatial coordinates; and means for interpolating the true spatial coordinates of the detected radiation events located intermediate the stored true spatial coordinates, said means for interpolating communicating with said means for storing

Excision repair in ataxia telangiectasia, Fanconi's anemia, Cockayne syndrome, and Bloom's syndrome after treatment with ultraviolet radiation and N-acetoxy-2-acetylaminofluorene

International Nuclear Information System (INIS)

Ahmed, F.E.; Setlow, R.B.

1978-01-01

Excision repair of damage due to ultraviolet radiation, N-acetoxy-2-acetylaminofluorene and a combination of both agents was studied in normal human fibroblasts and various cells from cancer prone patients (ataxia telangiectasia, Fanconi's anemia, Cockayne syndrome and Bloom's syndrome). Three methods giving similar results were used: unscheduled DNA synthesis by radioautography, photolysis of bromodeoxyuridine incorporated into parental DNA during repair, and loss of sites sensitive to an ultraviolet endonuclease. All cell lines were proficient in repair of ultraviolet and acetoxy acetylaminofluorene damage and at saturation doses of both agents repair was additive. We interpret these data as indicating that the rate limiting step in excision repair of ultraviolet and acetoxy acetylaminofluorene is different and that there are different enzyme(s) working on incision of both types of damages. (Auth.)

Compartment Syndrome as a Result of Systemic Capillary Leak Syndrome

Directory of Open Access Journals (Sweden)

Kwadwo Kyeremanteng

2016-01-01

Full Text Available Objective. To describe a single case of Systemic Capillary Leak Syndrome (SCLS with a rare complication of compartment syndrome. Patient. Our patient is a 57-year-old male, referred to our hospital due to polycythemia (hemoglobin (Hgb of 220 g/L, hypotension, acute renal failure, and bilateral calf pain. Measurements and Main Results. The patient required bilateral forearm, thigh, and calf fasciotomies during his ICU stay and continuous renal replacement therapy was instituted following onset of acute renal failure and oliguria. Ongoing hemodynamic (Norepinephrine and Milrinone infusion and respiratory (ventilator support in the ICU was provided until resolution of intravascular fluid extravasation. Conclusions. SCLS is an extremely rare disorder characterized by unexplained episodic capillary hyperpermeability, which causes shift of volume and protein from the intravascular space to the interstitial space. Patients present with significant hypotension, hemoconcentration, hypovolemia, and oliguria. Severe edema results from leakage of fluid and proteins into tissue. The most important part of treatment is maintaining stable hemodynamics, ruling out other causes of shock and diligent monitoring for complications. Awareness of the clinical syndrome with the rare complication of compartment syndrome may help guide investigations and diagnoses of these critically ill patients.

Development of radiation dose assessment system for radiation accident (RADARAC)

International Nuclear Information System (INIS)

Takahashi, Fumiaki; Shigemori, Yuji; Seki, Akiyuki

2009-07-01

The possibility of radiation accident is very rare, but cannot be regarded as zero. Medical treatments are quite essential for a heavily exposed person in an occurrence of a radiation accident. Radiation dose distribution in a human body is useful information to carry out effectively the medical treatments. A radiation transport calculation utilizing the Monte Carlo method has an advantageous in the analysis of radiation dose inside of the body, which cannot be measured. An input file, which describes models for the accident condition and quantities of interest, should be prepared to execute the radiation transport calculation. Since the accident situation, however, cannot be prospected, many complicated procedures are needed to make effectively the input file soon after the occurrence of the accident. In addition, the calculated doses are to be given in output files, which usually include much information concerning the radiation transport calculation. Thus, Radiation Dose Assessment system for Radiation Accident (RADARAC) was developed to derive effectively radiation dose by using the MCNPX or MCNP code. RADARAC mainly consists of two parts. One part is RADARAC - INPUT, which involves three programs. A user can interactively set up necessary resources to make input files for the codes, with graphical user interfaces in a personnel computer. The input file includes information concerning the geometric structure of the radiation source and the exposed person, emission of radiations during the accident, physical quantities of interest and so on. The other part is RADARAC - DOSE, which has one program. The results of radiation doses can be effectively indicated with numerical tables, graphs and color figures visibly depicting dose distribution by using this program. These results are obtained from the outputs of the radiation transport calculations. It is confirmed that the system can effectively make input files with a few thousand lines and indicate more than 20

RTP Radiation Monitoring System

International Nuclear Information System (INIS)

Alfred, S.L.; Mohd Fairus Abdul Farid; Ahmad Nabil Abdul Rahim; Nurhayati Ramli

2015-01-01

Radiation Monitoring System aiming to limiting dose exposed to personnel to the lowest level referring to the concept of ALARA (As Low As Reasonably Achievable). Atomic Energy Licensing (Basic Safety Radiation Protection) Regulation 2010 (Act 304) is a baseline to control employee and public radiation protection program and guideline, as well as to meet the requirement of the Occupational Safety and Health 1994 (Act 514). (author)

A new radiation exposure record system

International Nuclear Information System (INIS)

Lyon, M.; Berndt, V.L.; Trevino, G.W.; Oakley, B.M.

1993-04-01

The Hanford Radiological Records Program (HRRP) serves all Hanford contractors as the single repository for radiological exposure for all Hanford employees, subcontractors, and visitors. The program administers and preserves all Hanford radiation exposure records. The program also maintains a Radiation Protection Historical File which is a historical file of Hanford radiation protection and dosimetry procedures and practices. Several years ago DOE declared the existing UNIVAC mainframe computer obsolete and the existing Occupational Radiation Exposure (ORE) system was slated to be redeveloped. The new system named the Radiological Exposure (REX) System is described in this document

Radiation effects on living systems

International Nuclear Information System (INIS)

Hawley, N.J.

1984-04-01

This bibliography includes papers and reports by Atomic Energy of Canada Limited scientists concerning radiation effects on living systems. It is divided into three sections: Radiobiology, Radiation Biochemistry and Radiation Chemistry. It is intended that the bibliography will be updated regularly

Semiconductor radiation detection systems

CERN Document Server

2010-01-01

Covers research in semiconductor detector and integrated circuit design in the context of medical imaging using ionizing radiation. This book explores other applications of semiconductor radiation detection systems in security applications such as luggage scanning, dirty bomb detection and border control.

A control system of radiation protection at HESYRL

International Nuclear Information System (INIS)

Li Yuxiong; Li Juexin; Ning Xinquan

1990-01-01

A control system for radiation protection at Hefei National Synchrotron Radiation Laboratory (HESYRL) consists of three parts. They are a personal radiation safety interlock system, an automatic environmental radiation monitoring system and a data logging and management system for area radiation monitoring. Two-year operating experiments have shown that this system is reasonably designed, reliable, high-sensitive and automatic. The design principle, construction and operating status of each part of the system are introduced

Environmental radiation telemetering system

International Nuclear Information System (INIS)

Kikuchi, Hideo

1983-01-01

The Atomic Energy Center of Miyagi Prefecture introduced a telemetering system in 1982 for the purpose of monitoring human external exposure to radiation, and started preliminary examination for the radiation monitoring aound the Onagawa Nuclear Power Station, Tohoku Electric Power Co., in October, 1982, prior to its commencement of operation scheduled in June, 1984. This system roughly consists of three elements: monitoring stations (MSs) for the continuous observation of radiation, weather condition and other items; the monitoring center to collect the primary data obtained in each MS and to implement on-line data computation, data filing and display; and sub-centers for informing the data obtained by each MS to the people around it. Six MSs were installed in the region of radius of several km from the nuclear power plant. All or a part of the following items are measured in MSs: exposure on a basis of DBM (descrimination bias modulation), γ-spectra, exposure data of ionization chambers, wind direction and speed, rainfall, moisture in the ground, temperature, sunshine and radiation balance. In addition, in this report, also the system configuration, and online and off-line data processing are described. Environmental radiation does not seem to be fully grasped because it complicatedly varies due to weather conditions and other causes. The monitoring method of Miyagi Prefecture is expected to aid the clarification, though it is not yet established. (Wakatsuki, Y.)

Environmental radiation monitoring system

International Nuclear Information System (INIS)

Kato, Tsutomu; Shioiri, Masatoshi; Sakamaki, Tsuyoshi

2007-01-01

Environmental radiation monitoring systems are used to measure and monitoring gamma-rays at the observation boundaries of nuclear facilities and in the surrounding areas. In recent years, however, few new nuclear facilities have been constructed and the monitoring systems shift to renewal of existing systems. In addition, in order to increase public acceptance, the facilities are being equipped with communication lines to provide data to prefectural environmental centers. In this text, we introduce the latest technology incorporated in replacement of environmental radiation monitoring systems. We also introduce a replacement method that can shorten the duration during which environmental dose rate measurement is interrupted by enabling both the replacement system and the system being replaced to perform measurements in parallel immediately before and after the replacement. (author)

Radiation detection system

Science.gov (United States)

Whited, R.C.

A system for obtaining improved resolution in relatively thick semiconductor radiation detectors, such as HgI/sub 2/, which exhibit significant hole trapping. Two amplifiers are used: the first measures the charge collected and the second the contribution of the electrons to the charge collected. The outputs of the two amplifiers are utilized to unfold the total charge generated within the detector in response to a radiation event.

Development trend of radiation biology research-systems radiation biology

International Nuclear Information System (INIS)

Min Rui

2010-01-01

Radiation biology research has past 80 years. We have known much more about fundamentals, processes and results of biology effects induced by radiation and various factors that influence biology effects wide and deep, however many old and new scientific problems occurring in the field of radiation biology research remain to be illustrated. To explore and figure these scientific problems need systemic concept, methods and multi dimension view on the base of considerations of complexity of biology system, diversity of biology response, temporal and spatial process of biological effects during occurrence, and complex feed back network of biological regulations. (authors)

Degree and therapy of acute radiation syndromes. Introduction of a suggestion on acute radiation sickness therapy made by strategic national stockpile radiation working group of USA. part 2

International Nuclear Information System (INIS)

Min Rui; Pan Zhen; Li Yu

2005-01-01

Recommendations based on radiation dose and physiologic response are made for treatment of the hematopoietic syndrome. Therapy includes treatment with hematopoietic cytokines, blood transfusion, and stem-cell transplantation in selected cases. Additional medical management based on the evolution of clinical signs and symptoms includes the use of antimicrobial agents (quinolones, antiviral therapy, and antifungal agents), antiemetic agents, and analgesic agents. Because of the strong psychological impact of a possible radiation exposure, psychosocial support will be required for those exposed, regardless of the dose, as well as for family and friends. Treatment of pregnant women must account for risk to the fetus. For terrorist or accidental events involving exposure to radioiodines, prophylaxis against malignant disease of the thyroid is also recommended, particularly for children and adolescents. (authors)

Bone marrow transplantation and other treatment after radiation injury

International Nuclear Information System (INIS)

Balner, H.

1977-01-01

This review deals mainly with current concepts about bone marrow transplantation as therapy for serious radiation injury. Such injury can be classified according to the following broadly defined dose ranges: (1) the supralethal range, leading mainly to the cerebral and intestinal syndromes; (2) the potentially lethal or therapeutic range which causes the bone marrow syndrome, and (3) the sublethal range which rarely leads to injury requiring therapy. The bone marrow syndrome of man and animals is discussed in detail. The optimal therapy for this syndrome is bone marrow transplantation in conjunction with conventional supportive treatment. The principal complications of such therapy are Graft versus Host Disease and a slow recovery of the recipient's immune system. Concerted research activities in a number of institutions have led to considerable progress in the field of bone marrow transplantation. Improved donor selection, new techniques for stem-cell separation and preservation, as well as effective barrier-nursing and antibiotic decontamination, have made bone marrow transplantation an accepted therapy for marrow depression, including the aplasia caused by excessive exposure to radiation. The review also contains a number of guidelines for the handling of serious radiation accidents. (Auth.)

Radiation oncology systems integration

International Nuclear Information System (INIS)

Ragan, D.P.

1991-01-01

ROLE7 is intended as a complementary addition to the HL7 Standard and not as an alternative standard. Attempt should be made to mould data elements which are specific to radiation therapy with existing HL7 elements. This can be accomplished by introducing additional values to some element's table-of-options. Those elements which might be specific to radiation therapy could from new segments to be added to the Ancillary Data Reporting set. In order to accomplish ROLE7, consensus groups need be formed to identify the various functions related to radiation oncology that might motivate information exchange. For each of these functions, the specific data elements and their format must be identified. HL7 is organized with a number of applications which communicate asynchronously. Implementation of ROLE7 would allow uniform access to information across vendors and functions. It would provide improved flexibility in system selection. It would allow a more flexible and affordable upgrade path as systems in radiation oncology improve. (author). 5 refs

Monitoring and crisis system of radiation safety

International Nuclear Information System (INIS)

Bartok, J.; Borovansky, P.; Macica, J.; Petrovicova, M.

2005-01-01

In this paper we have briefly described our practical experiences with the most complex Radiation Monitoring System we have designed. This system consists of number of stations; those data are collected in the main crisis center of the whole system. The main center integrates RMS Central Database, the IMS Model Suite workstation and the Graphics workstation. The radiations probes of the RP series are the base for stationary , portable sets and for sets measuring underwater radiation. The radiation and meteorological data, which are necessary for reasonable interpretation of radiation data, are archived in RMS Central database. The Lagrangian trajectory model from the IMS Model Suite serves for radiation dispersion modeling. (authors)

Digital radiation monitor system

International Nuclear Information System (INIS)

Quan Jinhu; Zhai Yongchun; Guan Junfeng; Ren Dangpei; Ma Zhiyuan

2003-01-01

The article introduced digital radiation monitor system. The contents include: how to use advanced computer net technology to establish equipment net for nuclear facility, how to control and manage measuring instruments on field equipment net by local area net, how to manage and issue radiation monitoring data by internet

Method of inhibiting the onset of acute radiation syndrome and also inhibiting the onset of septicemia and a composition therefor

Energy Technology Data Exchange (ETDEWEB)

Ribi, E E

1986-01-14

A method is described for inhibiting the onset of acute radiation syndrome caused by the exposure of warm-blooded animals to a whole body dose of at least 100 rads of x-radiation. Also described is a method for inhibiting the onset of septicemia. The methods comprise administering to a warm-blooded animal an effective amount of a pharmaceutical preparation containing refined detoxified endotoxin in combination with a pharmaceutically acceptable carrier.

Radiation detection system

International Nuclear Information System (INIS)

Haeuszer, F.A.

1976-01-01

A circuit is disclosed that detects radiation transients and provides a clamping signal in response to each transient. The clamping signal is present from the time the transient rises above a given threshold level and for a known duration thereafter. The system includes radiation sensors, a blocking oscillator that generates a pulse in response to each sensor signal, and an output pulse duration control circuit. The oscillator pulses are fed simultaneously to the output pulse duration control circuit and to an OR gate, the output of which comprises the system output. The output pulse duration is controlled by the time required to magnetize a magnetic core to saturation in first one direction and then the other

Radiation detecting system

International Nuclear Information System (INIS)

1975-01-01

In spectrophotometry systems, a usual arrangement for modulating the radiation is a rotating disc having one or more sectors removed. A beam of radiation may be blocked by the disc except when a cut-away sector is in the path of the beam. With a double-beam system, a cut-away sector of 180 0 may be used so that when the first path is blocked, the second is allowed through, and vice versa. One or both sides of the disc may be formed as mirrors to facilitate beam switching and to allow use of more than two beams for background compensation purposes or for analysis of more than one substance within a sample. (G.T.H.)

Monitoring System For Improving Radiation Safety Management

International Nuclear Information System (INIS)

Osovizky, A.; Paran, J.; Tal, N.; Ankry, N.; Ashkenazi, B.; Tirosh, D.; Marziano, R.; Chisin, R.

1999-01-01

Medi SMARTS (Medical Survey Mapping Automatic Radiation Tracing System), a gamma radiation monitoring system, was installed in a nuclear medicine department. In this paper the evaluation of the system's ability to improve radiation safety management is presented. The system is based on a state of the art software that continuously collects on line radiation measurements for display, analysis and logging. Radiation is measured by GM tubes; the signal is transferred to a data processing unit and then via an RS-485 communication line to a computer. The system automatically identifies the detector type and its calibration factor, thus providing compatibility, maintainability and versatility when changing detectors. Radiation levels are displayed on the nuclear medicine department map at six locations. The system has been operating continuously for more than one year, documenting abnormal events caused by routine operation or failure incidents. In cases where abnormal working conditions were encountered, an alarm message was sent automatically to the supervisor via his tele-pager. An interesting issue observed during the system evaluation, was the inability to distinguish between high radiation levels caused by proper routine operation and those caused by safety failure incidents. The solution included examination of two parameters, radiation levels as well as their duration period. A careful analysis of the historical data, applying the appropriated combined parameters determined for each location, verified that such a system can identify abnormal events, provide alarms to warn in case of incidents and improve standard operating procedures

Management information system on radiation protection

Energy Technology Data Exchange (ETDEWEB)

Grossi, Pablo Andrade; Souza, Leonardo Soares de; Figueiredo, Geraldo Magela, E-mail: pabloag@cdtn.b, E-mail: lss@cdtn.b, E-mail: gmf@cdtn.b [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)

2011-07-01

Considering the flux complexity and the multi source information of all radiation protection activities on nuclear organizations, an effective management information system based on technology, information and people is necessary to improve the safety on all processes and operations subjected to radiation risks. An effective management information system is an essential tool to highlight the strengths and weaknesses and identify behaviors and trends on the activities requiring radiation protection programs. Such kind of distinct knowledge is useful to reach an effective management and support the human decision-making on nuclear organization. This paper presents a management information system based on Brazilian directives and regulations on radiation protection. Due to its generic characteristics, this radiation protection control system can be implemented on any nuclear organization by reediting the non restricted parameters which could differ considering all facilities and laboratories expected on-site with diverse technologies applications. This system can be considered as a powerful tool applied on the continuous management of radiation protection activities on nuclear organizations and research institutes as well as for long term planning, not only indicating how the safety activities are going, but why they are not going as well as planned where that is the case. (author)

Management information system on radiation protection

International Nuclear Information System (INIS)

Grossi, Pablo Andrade; Souza, Leonardo Soares de; Figueiredo, Geraldo Magela

2011-01-01

Considering the flux complexity and the multi source information of all radiation protection activities on nuclear organizations, an effective management information system based on technology, information and people is necessary to improve the safety on all processes and operations subjected to radiation risks. An effective management information system is an essential tool to highlight the strengths and weaknesses and identify behaviors and trends on the activities requiring radiation protection programs. Such kind of distinct knowledge is useful to reach an effective management and support the human decision-making on nuclear organization. This paper presents a management information system based on Brazilian directives and regulations on radiation protection. Due to its generic characteristics, this radiation protection control system can be implemented on any nuclear organization by reediting the non restricted parameters which could differ considering all facilities and laboratories expected on-site with diverse technologies applications. This system can be considered as a powerful tool applied on the continuous management of radiation protection activities on nuclear organizations and research institutes as well as for long term planning, not only indicating how the safety activities are going, but why they are not going as well as planned where that is the case. (author)

A unique radiation area monitoring system

International Nuclear Information System (INIS)

Murphy, P.C.; Allen, G.C.

1978-01-01

The Remote Area Monitoring Systems (RAMS) monitors four radiation areas with two independent systems in each area. Each system consists of power supplies, four ionization chambers, and four analog and digital circuits. The first system controls the warning beacons, horns, annunciation panel and interlocks. The second system presents a quantitative dose rate indication at the console and in the radiation area

Radiation management computer system for Monju

International Nuclear Information System (INIS)

Aoyama, Kei; Yasutomo, Katsumi; Sudou, Takayuki; Yamashita, Masahiro; Hayata, Kenichi; Ueda, Hajime; Hosokawa, Hideo

2002-01-01

Radiation management of nuclear power research institutes, nuclear power stations and other such facilities are strictly managed under Japanese laws and management policies. Recently, the momentous issues of more accurate radiation dose management and increased work efficiency has been discussed. Up to now, Fuji Electric Company has supplied a large number of Radiation Management Systems to nuclear power stations and related nuclear facilities. We introduce the new radiation management computer system with adopted WWW technique for Japan Nuclear Cycle Development Institute, MONJU Fast Breeder Reactor (MONJU). (author)

Shrinking lung syndrome complicating pediatric systemic lupus erythematosus

Energy Technology Data Exchange (ETDEWEB)

Burns, Natalie S. [University of Washington Medical Center, Department of Radiology, Seattle, WA (United States); Stevens, Anne M. [Seattle Children' s Hospital, Division of Rheumatology, Department of Pediatrics, Seattle, WA (United States); Iyer, Ramesh S. [University of Washington School of Medicine, Seattle Children' s Hospital, Department of Radiology, Seattle, WA (United States)

2014-10-15

Systemic lupus erythematosis (SLE) can affect the lungs and pleura, usually manifesting with pleural effusions or diffuse parenchymal disease. A rare manifestation of SLE is shrinking lung syndrome, a severe restrictive respiratory disorder. While pleuropulmonary complications of pediatric SLE are common, shrinking lung syndrome is exceedingly rare in children. We present a case of a 13-year-old girl previously diagnosed with lupus, who developed severe dyspnea on exertion and restrictive pulmonary physiology. Her chest radiographs on presentation demonstrated low lung volumes, and CT showed neither pleural nor parenchymal disease. Fluoroscopy demonstrated poor diaphragmatic excursion. While shrinking lung syndrome is described and studied in adults, there is only sparse reference to shrinking lung syndrome in children. (orig.)

Shrinking lung syndrome complicating pediatric systemic lupus erythematosus

International Nuclear Information System (INIS)

Burns, Natalie S.; Stevens, Anne M.; Iyer, Ramesh S.

2014-01-01

Systemic lupus erythematosis (SLE) can affect the lungs and pleura, usually manifesting with pleural effusions or diffuse parenchymal disease. A rare manifestation of SLE is shrinking lung syndrome, a severe restrictive respiratory disorder. While pleuropulmonary complications of pediatric SLE are common, shrinking lung syndrome is exceedingly rare in children. We present a case of a 13-year-old girl previously diagnosed with lupus, who developed severe dyspnea on exertion and restrictive pulmonary physiology. Her chest radiographs on presentation demonstrated low lung volumes, and CT showed neither pleural nor parenchymal disease. Fluoroscopy demonstrated poor diaphragmatic excursion. While shrinking lung syndrome is described and studied in adults, there is only sparse reference to shrinking lung syndrome in children. (orig.)

The design of radiation monitor passageway system

International Nuclear Information System (INIS)

Chu Chengsheng

2006-10-01

The Radiation Monitor Passageway System is designed as four modules, the radiation detection modules, the control modules, the mechanism modules and the optional modules. this system integrate the radiation detection technology and door ban control technology. It is a effective radiation monitor equipment with high detect sensitiveness, it will be hopeful devoted to national nuclear safeguard. (authors)

Health Impacts from Acute Radiation Exposure

Energy Technology Data Exchange (ETDEWEB)

Strom, Daniel J.

2003-09-30

Absorbed doses above1-2 Gy (100-200 rads) received over a period of a day or less lead to one or another of the acute radiation syndromes. These are the hematopoietic syndrome, the gastrointestinal (GI) syndrome, the cerebrovascular (CV) syndrome, the pulmonary syndrome, or the cutaneous syndrome. The dose that will kill about 50% of the exposed people within 60 days with minimal medical care, LD50-60, is around 4.5 Gy (450 rads) of low-LET radiation measured free in air. The GI syndrome may not be fatal with supportive medical care and growth factors below about 10 Gy (1000 rads), but above this is likely to be fatal. Pulmonary and cutaneous syndromes may or may not be fatal, depending on many factors. The CV syndrome is invariably fatal. Lower acute doses, or protracted doses delivered over days or weeks, may lead to many other health outcomes than death. These include loss of pregnancy, cataract, impaired fertility or temporary or permanent sterility, hair loss, skin ulceration, local tissue necrosis, developmental abnormalities including mental and growth retardation in persons irradiated as children or fetuses, radiation dermatitis, and other symptoms listed in Table 2 on page 12. Children of parents irradiated prior to conception may experience heritable ill-health, that is, genetic changes from their parents. These effects are less strongly expressed than previously thought. Populations irradiated to high doses at high dose rates have increased risk of cancer incidence and mortality, taken as about 10-20% incidence and perhaps 5-10% mortality per sievert of effective dose of any radiation or per gray of whole-body absorbed dose low-LET radiation. Cancer risks for non-uniform irradiation will be less.

Chronic effects of ionizing radiation on animals and humans

International Nuclear Information System (INIS)

Drozd, Yi.P.

2013-01-01

Numerous experimental radiobiological studies and medical observations were conducted after the Chernobyl disaster based on the published results; patterns and characteristics influence of the fission products of nuclear materials on the body of mammals, including humans were analyzed. Chronic exposure to low doses leads to the changes in the hemopoietic system was founded and increases the risk of myeloproliferative diseases. The consequence of radiation-related immunodeficiency is the autoimmune disease and chronic fatigue syndrome. Radiation damage leads to endocrine system disruption of the body and of polipatologycal states. High radiosensitivity of the central nervous system was founded. Genotoxic chronic radiation exposure threatens the stability of the genome

Effects of radiation on erythropoiesis

Energy Technology Data Exchange (ETDEWEB)

Harriss, E B

1971-04-01

Since the pioneer work of Heineke (1903; 1905) many workers have studied the effect of radiation on haemopoiesis. Their work has been reviewed by Bloom (1948), by Jacobson (1954) and more recently by Bond et al. (1965). The subject continues to stimulate much interest but is now more concerned with the effects of radiation on the multipotential stem cell pool than on radiation damage to the erythropoietic cells themselves. Death from haemopoietic failure following an LD{sub 50/30} dose of radiation is probably not attributable to failure of erythropoiesis; while damage to the erythropoietic system certainly plays a part in the syndrome, it is not a major factor contributing to the death of the animal. Although the severity and time course of the response vary with the species studied, the general effects of radiation on erythropoiesis are similar in all mammalian bone marrow studied to date. Likewise, though the severity of the reaction varies somewhat with the energy of the radiation and has been used to compare the relative biological effectiveness of different types of radiation (Sinclair et al., 1962; Sztanyik, 1967), the response is different only in degree and not in its fundamental pattern. The initial syndrome of depression and recovery will therefore be described largely by reference to work performed on the response of the rat to single acute exposures of either whole-body or partial-body irradiation with conventional X-rays.

Acute Radiation Effects Resulting from Exposure to Solar Particle Event-Like Radiation

Science.gov (United States)

Kennedy, Ann; Cengel, Keith

2012-07-01

A major solar particle event (SPE) may place astronauts at significant risk for the acute radiation syndrome (ARS), which may be exacerbated when combined with other space flight stressors, such that the mission or crew health may be compromised. The National Space Biomedical Research Institute (NSBRI) Center of Acute Radiation Research (CARR) is focused on the assessment of risks of adverse biological effects related to the ARS in animal models exposed to space flight stressors combined with the types of radiation expected during an SPE. As part of this program, FDA-approved drugs that may prevent and/or mitigate ARS symptoms are being evaluated. The CARR studies are focused on the adverse biological effects resulting from exposure to the types of radiation, at the appropriate energies, doses and dose-rates, present during an SPE (and standard reference radiations, gamma rays or electrons). The ARS is a phased syndrome which often includes vomiting and fatigue. Other acute adverse biologic effects of concern are the loss of hematopoietic cells, which can result in compromised bone marrow and immune cell functions. There is also concern for skin damage from high SPE radiation doses, including burns, and resulting immune system dysfunction. Using 3 separate animal model systems (ferrets, mice and pigs), the major ARS biologic endpoints being evaluated are: 1) vomiting/retching and fatigue, 2) hematologic changes (with focus on white blood cells) and immune system changes resulting from exposure to SPE radiation with and without reduced weightbearing conditions, and 3) skin injury and related immune system functions. In all of these areas of research, statistically significant adverse health effects have been observed in animals exposed to SPE-like radiation. Countermeasures for the management of ARS symptoms are being evaluated. New research findings from the past grant year will be discussed. Acknowledgements: This research is supported by the NSBRI Center of Acute

Substance P immunoreactivity in the enteric nervous system in Rett syndrome.

Science.gov (United States)

Deguchi, K; Reyes, C; Chakraborty, S; Antalffy, B; Glaze, D; Armstrong, D

2001-12-01

Rett syndrome is associated with profound mental retardation and motor disability in girls. It has a characteristic clinical phenotype which includes abnormalities of the autonomic nervous system. Feeding impairment and severe constipation are two symptoms of this autonomic dysfunction. Substance P, an important peptide in the autonomic nervous system, is decreased in the cerebrospinal fluid of Rett syndrome. We have demonstrated that substance P immunoreactivity is significantly decreased in Rett syndrome brain-stem and may be related to the autonomic dysfunction. In this study, we have continued the investigation of substance P in the enteric nervous system. We immunohistochemically examined the normal developing bowel in 22 controls (ages, 14 gestational weeks to 31 years) using formalin fixed tissue, with antibodies to substance P, tyrosine hydroxylase and vasoactive intestinal peptide. We compared the immunoreactivity of normal controls with 14 cases of Rett syndrome (ages, 5-41 years) and observed that the expression of substance P, tyrosine hydroxylase and vasoactive intestinal peptide immunoreactivity in the bowel in Rett syndrome was not significantly different from that of controls. This suggests that the feeding impairment and constipation in Rett syndrome relate to dysfunction of the autonomic nervous system originating outside of the bowel, in the brain-stem, as suggested by our previous study.

The role of protective systems in cell homeostasis upon gamma radiation

International Nuclear Information System (INIS)

Zasuxina, Q.D.

2002-01-01

There are a number of parameters that are used for the estimation of cell defence against radiation and chemicals: induced initial DNA damage, residual damage after a period of repair, rate and fidelity of repair, endpoint (chromosomal changes and cell survival). Antioxidant enzymes are main pathway of cell defence: superoxide dismutase (SOD), catalase, glutatione peroxidase, glutatione-S-transferase et al. Key enzyme is SOD which naturalizes reactive oxygen species (ROS). ROS are main damaging component of the radiation and some chemical action. Glutatione-S-transferase (GST) conjugates ROS to glutatione prior to their excretion from the body. The GST M1 null (one from family of GST) genotype is found in about 50% Europeans, Japanese, but only one-quarter of Afro-Americans. Lack of this enzyme may result in deficient detoxification leading to increase sensitivity to mutagens and in risk of cancer. Another system of cell defence involves enzymes taking part in DNA repair: base excision repair, nucleotide excision repair, mismatch repair et al. A radio adaptive response (RAR) also can serve as cell defence system. RAR forms a cell resistance to gamma-radiation after cell pretreatment with low doses of radiation and some incubation (3-4 hours). Purpose of our investigation: 1) to estimate the role of SOD in human cells isolated from healthy donors, children with some repair-deficient diseases (Bloom syndrome, Marfan syndrome) and children from area with an increased level of radiation; 2) to compare SOD activity in human cells and human cells during RAR; 3) to study a possible link between cell survival and initial damage of DNA after treatment with TRIEN - inhibitor of SOD - and with garlic extract - natural anti mutagen. We found the increased level of damage of DNA in trien-pretreated cells (healthy and repair-deficient cells). However this level was similar in lymphocytes of children from areas with an increased level of radiation without and with trien

The personnel protection system for a Synchrotron Radiation Accelerator Facility: Radiation safety perspective

International Nuclear Information System (INIS)

Liu, J.C.

1993-05-01

The Personnel Protection System (PPS) at the Stanford Synchrotron Radiation Laboratory is summarized and reviewed from the radiation safety point of view. The PPS, which is designed to protect people from radiation exposure to beam operation, consists of the Access Control System (ACS) and the Beam Containment System (BCS), The ACS prevents people from being exposed to the very high radiation level inside the shielding housing (also called a PPS area). The ACS for a PPS area consists of the shielding housing and a standard entry module at every entrance. The BCS prevents people from being exposed to the radiation outside a PPS area due to normal and abnormal beam losses. The BCS consists of the shielding (shielding housing and metal shielding in local areas), beam stoppers, active current limiting devices, and an active radiation monitor system. The system elements for the ACS and BCS and the associated interlock network are described. The policies and practices in setting up the PPS are compared with some requirements in the US Department of Energy draft Order of Safety of Accelerator Facilities

Prognostic significance of gastrointestinal symptoms and diagnosis in relation to the acute radiation syndrome. A retrospective analysis based on the data base SEARCH

International Nuclear Information System (INIS)

Hoebbel, Mathias Niklaus Johannes

2016-01-01

The following thesis explores the prognostic significance of gastrointestinal symptoms and diagnoses in relation to acute radiation syndrome. This is a retrospective analysis based on the SEARCH (System of Evaluation and Archiving of Radiation Accidents based on Case Histories) database, which was created by a team of researchers in Ulm in 1998. The SEARCH database compiled health status data of individuals involved in a total of 78 ionized radiation accidents between 1945 and 2003. In the past changes in bloodbuilding systems were considered the defining factor in determining a prognosis regarding survival times. Treatment decisions were made in line with these findings, including stem-cell transplants. In recent history, especially after the nuclear disaster in Chernobyl in 1986, the focus shifted onto other organ systems. As a result it has been proven that significant cutaneous damages present an important influence on survival regardless of haematopoiesis. Several researchers have looked at changes in the gastrointestinal tract and possible correlations with radiation induced multiple organ failure. In this paper, all of the data recorded in SEARCH in regards to gastrointestinal symptoms have been analyzed. These include symptoms such as nausea, vomiting and changes in bowel movement as well as their onset and severity. Radiation-induced oral mucositis was also further investigated. Despite the occasional gaps in data in SEARCH, results from the analysis proved that the occurrence of certain symptoms, their severity and their onset were directly correlated to life expectancy, regardless of the dose estimation, and the pending blood test results. An immediate triage of these patients by skilled medical professionals is imperative to accurate categorization.

Syndromes that simulate a juvenile systemic arthritis; on purpose of a case of NOMID/CINCA syndrome

International Nuclear Information System (INIS)

Gamarra Iglesias, Antonio; Rojas, Adriana; Calvo P, Enrique; Restrepo S, Jose Felix

2004-01-01

We report a years old female with NOMID/CINCA syndrome, and we reviewed of this rare pathology. We discuss the differential diagnosis of this disease with all of the syndromes in the childhood that resemble a systemic arthritis, specially when this appears before the two years of age

Strategies for Discovery of Small Molecule Radiation Protectors and Radiation Mitigators

Energy Technology Data Exchange (ETDEWEB)

Greenberger, Joel S.; Clump, David [Radiation Oncology Department, University of Pittsburgh Cancer Institute, Pittsburgh, PA (United States); Kagan, Valerian [Environmental and Occupational Health Department, University of Pittsburgh, Pittsburgh, PA (United States); Bayir, Hülya [Critical Care Medicine Department, University of Pittsburgh Medical Center, Pittsburgh, PA (United States); Lazo, John S. [Pharmacology Department, University of Virginia, Charlottesville, VA (United States); Wipf, Peter [Department of Chemistry, Accelerated Chemical Discovery Center, University of Pittsburgh, Pittsburgh, PA (United States); Li, Song; Gao, Xiang [Pharmaceutical Science Department, University of Pittsburgh, Pittsburgh, PA (United States); Epperly, Michael W., E-mail: greenbergerjs@upmc.edu [Radiation Oncology Department, University of Pittsburgh Cancer Institute, Pittsburgh, PA (United States)

2012-01-13

Mitochondrial targeted radiation damage protectors (delivered prior to irradiation) and mitigators (delivered after irradiation, but before the appearance of symptoms associated with radiation syndrome) have been a recent focus in drug discovery for (1) normal tissue radiation protection during fractionated radiotherapy, and (2) radiation terrorism counter measures. Several categories of such molecules have been discovered: nitroxide-linked hybrid molecules, including GS-nitroxide, GS-nitric oxide synthase inhibitors, p53/mdm2/mdm4 inhibitors, and pharmaceutical agents including inhibitors of the phosphoinositide-3-kinase pathway and the anti-seizure medicine, carbamazepine. Evaluation of potential new radiation dose modifying molecules to protect normal tissue includes: clonogenic radiation survival curves, assays for apoptosis and DNA repair, and irradiation-induced depletion of antioxidant stores. Studies of organ specific radioprotection and in total body irradiation-induced hematopoietic syndrome in the mouse model for protection/mitigation facilitate rational means by which to move candidate small molecule drugs along the drug discovery pipeline into clinical development.

Radiation monitoring system based on EPICS

International Nuclear Information System (INIS)

Wang Weizhen; Li Jianmin; Wang Xiaobing; Hua Zhengdong; Xu Xunjiang

2008-01-01

Shanghai Synchrotron Radiation Facility (SSRF for short) is a third-generation light source building in China, including a 150 MeV injector, 3.5 GeV booster, 3.5 GeV storage ring and an amount of beam line stations. During operation, a mass of Synchrotron Radiation will be produced by electrons in the booster and the storage ring. Bremsstrahlung and neutrons will also be produced as a result of the interaction between the electrons, especially the beam loss, and the wall of the vacuum beam pipe. SSRF Radiation Monitoring System is established for monitoring the radiation dosage of working area and environment while SSRF operating. The system consists of detectors, intelligent data-collecting modules, monitoring computer, and managing computer. The software system is developed based on EPICS (Experimental Physics and Industrial Control System), implementing the collecting and monitoring the data output from intelligent modules, analyzing the data, and so on. (authors)

47 CFR 22.383 - In-building radiation systems.

Science.gov (United States)

2010-10-01

... MOBILE SERVICES Operational and Technical Requirements Technical Requirements § 22.383 In-building radiation systems. Licensees may install and operate in-building radiation systems without applying for... 47 Telecommunication 2 2010-10-01 2010-10-01 false In-building radiation systems. 22.383 Section...

Distributed radiation protection console system

International Nuclear Information System (INIS)

Chhokra, R.S.; Deshpande, V.K.; Mishra, H.; Rajeev, K.P.; Thakur, Bipla B.; Munj, Niket

2004-01-01

Radiation exposure control is one of the most important aspects in any nuclear facility . It encompasses continuous monitoring of the various areas of the facility to detect any increase in the radiation level and/or the air activity level beyond preset limits and alarm the O and M personnel working in these areas. Detection and measurement of radiation level and the air activity level is carried out by a number of monitors installed in the areas. These monitors include Area Gamma Monitors, Continuous Air Monitors, Pu-In-Air Monitors, Criticality Monitors etc. Traditionally, these measurements are displayed and recorded on a Central Radiation Protection Console(CRPC), which is located in the central control room of the facility. This methodology suffers from the shortcoming that any worker required to enter a work area will have to inquire about the radiation status of the area either from the CRPC or will get to know the same directly from the installed only after entering the area. This shortcoming can lead to avoidable delays in attending to the work or to unwanted exposure. The authors have designed and developed a system called Distributed Radiation Protection Console (DRPC) to overcome this shortcoming. A DRPC is a console which is located outside the entrance of a given area and displays the radiation status of the area. It presents to health physicist and the plant operators a graphic over-view of the radiation and air activity levels in the particular area of the plant. It also provides audio visual annunciation of the alarm status. Each radioactive area in a nuclear facility will have its own DRPC, which will receive as its inputs the analog and digital signals from radiation monitoring instruments installed in the area and would not only show those readings on its video graphic screen but will also provide warning messages and instructions to the personnel entering the active areas. The various DRPCs can be integrated into a Local Area Network, where the

The systemic inflammatory response syndrome.

Science.gov (United States)

Robertson, Charles M; Coopersmith, Craig M

2006-04-01

The systemic inflammatory response syndrome (SIRS) is the body's response to an infectious or noninfectious insult. Although the definition of SIRS refers to it as an "inflammatory" response, it actually has pro- and anti-inflammatory components. This review outlines the pathophysiology of SIRS and highlights potential targets for future therapeutic intervention in patients with this complex entity.

Radiation-hardened control system

International Nuclear Information System (INIS)

Vandermolen, R.I.; Smith, S.F.; Emery, M.S.

1993-01-01

A radiation-hardened bit-slice control system with associated input/output circuits was developed to prove that programmable circuits could be constructed to successfully implement intelligent functions in a highly radioactive environment. The goal for this effort was to design and test a programmable control system that could withstand a minimum total dose of 10 7 rads (gamma). The Radiation Hardened Control System (RHCS) was tested in operation at a dose rate that ranged up to 135 krad/h, with an average total dose of 10.75 Mrads. Further testing beyond the required 10 7 rads was also conducted. RHCS performed properly through the target dose of 10 7 rads, and sporadic intermittent failures in some programmable logic devices were noted after ∼ 13 Mrads

Chronic effects of ionizing radiation on animals and humans

Directory of Open Access Journals (Sweden)

I. P. Drozd

2013-03-01

Full Text Available Numerous experimental radiobiological studies and medical observations were conducted after the Chernobyl disaster based on the published results; patterns and characteristics influence of the fission products of nuclear materials on the body of mammals, including humans were analyzed. Chronic exposure to low doses leads to the changes in the hemopoietic system was founded and increases the risk of myeloproliferative diseases. The con-sequence of radiation-related immunodeficiency is the autoimmune disease and chronic fatigue syndrome. Radi-ation damage leads to endocrine system disruption of the body and of polipatologycal states. High radiosensitivi-ty of the central nervous system was founded. Genotoxic chronic radiation exposure threatens the stability of the genome.

Upper bounds on the entropy of radiation systems

Institute of Scientific and Technical Information of China (English)

汪定雄

1997-01-01

The upper bounds on the entropy of a radiation system confined to a spherical box are calculated in six cases by using the equation of state of radiation in flat spacetime and the equation of state of radiation near black-hole horizon,which was derived by Li and Liu (hereafter the Li-Liu equation).It turns out that the Li-Liu equation does have unique advantage in dealing with the entropy bound of critical self-gravitating radiation systems,while the usual equation of state will result in entropy divergence.In the case of non-self-gravitating radiation systems and non-critical self-gravitating radiation systems,there is no difference in the entropy bounds derived by these two equations of state.

Radiative transfer in atmosphere-sea ice-ocean system

Energy Technology Data Exchange (ETDEWEB)

Jin, Z.; Stamnes, K.; Weeks, W.F. [Univ. of Alaska, Fairbanks, AK (United States); Tsay, S.C. [NASA Goddard Space Flight Center, Greenbelt, MD (United States)

1996-04-01

Radiative energy is critical in controlling the heat and mass balance of sea ice, which significantly affects the polar climate. In the polar oceans, light transmission through the atmosphere and sea ice is essential to the growth of plankton and algae and, consequently, to the microbial community both in the ice and in the ocean. Therefore, the study of radiative transfer in the polar atmosphere, sea ice, and ocean system is of particular importance. Lacking a properly coupled radiative transfer model for the atmosphere-sea ice-ocean system, a consistent study of the radiative transfer in the polar atmosphere, snow, sea ice, and ocean system has not been undertaken before. The radiative transfer processes in the atmosphere and in the ice and ocean have been treated separately. Because the radiation processes in the atmosphere, sea ice, and ocean depend on each other, this separate treatment is inconsistent. To study the radiative interaction between the atmosphere, clouds, snow, sea ice, and ocean, a radiative transfer model with consistent treatment of radiation in the coupled system is needed and is under development.

Radiation pneumonitis: a complication resulting from combined radiation and chemotherapy for early breast cancer

International Nuclear Information System (INIS)

Gez, E.; Sulkes, A.; Isacson, R.; Catane, R.; Weshler, Z.

1985-01-01

Described is a patient with early breast carcinoma who developed clinical radiation pneumonitis during primary radiation therapy and concomitant chemotherapy that included prednisone. This syndrome developed three days following abrupt steroid withdrawal. Retrieval of steroids brought complete resolution of the clinical and radiological findings. Although this syndrome is rare, it is recommended that steroid therapy in a patient previously irradiated to the chest be avoided

Integrated occupational radiation exposure information system

International Nuclear Information System (INIS)

Hunt, H.W.

1983-06-01

The integrated (Occupational Radiation Exposure) data base information system has many advantages. Radiation exposure information is available to operating management in a more timely manner and in a more flexible mode. The ORE system has permitted the integration of scattered files and data to be stored in a more cost-effective method that permits easy and simultaneous access by a variety of users with different data needs. The external storage needs of the radiation exposure source documents are several orders of magnitude less through the use of the computer assisted retrieval techniques employed in the ORE system. Groundwork is being layed to automate the historical files, which are maintained to help describe the radiation protection programs and policies at any one point in time. The file unit will be microfilmed for topical indexing on the ORE data base

Tissue response after radiation exposure. Intestine

International Nuclear Information System (INIS)

Otsuka, Kensuke; Tomita, Masanori; Yamauchi, Motohiro; Iwasaki, Toshiyasu

2014-01-01

Gastrointestinal syndrome followed by 'gut death' is due to intestinal disorders. This syndrome is induced by high-dose (>10 Gy) of ionizing radiation. Recovery from the gastrointestinal syndrome would depend on the number of survived clonogens and regeneration capability of crypts. These tissue alterations can be observed by high-dose radiation, however, cellular dynamics in crypts can be affected by low-dose radiation. For example, Potten et al. found that low-dose radiation induce apoptosis of intestinal stem cells, which produce all differentiated function cells. Recently, intestinal stem cells are characterized by molecular markers such as Lgr5. Since intestinal adenomas can be induced by deletion of Apc gene in Lgr5 + stem cells, it is widely recognized that Lgr5 + stem cells are the cell-of-origin of cancer. Duodenal Lgr5 + stem cells are known as radioresistant cells, however, we found that ionizing radiation significantly induces the turnover of colonic Lgr5 + stem cells. Combined with the knowledge of other radioresistant markers, stem-cell dynamics in tissue after irradiation are becoming clear. The present review introduces the history of gastrointestinal syndrome and intestinal stem cells, and discusses those future perspectives. (author)

LANSCE radiation security system (RSS)

International Nuclear Information System (INIS)

Gallegos, F.R.

1996-01-01

The Radiation Security System (RSS) is an engineered safety system which automatically terminates transmission of accelerated ion beams in response to pre-defined abnormal conditions. It is one of the four major mechanisms used to protect people from radiation hazards induced by accelerated pulsed ion beams at the Los Alamos Neutron Science Center (LANSCE). The others are shielding, administrative policies and procedures, and qualified, trained personnel. Prompt radiation hazards at the half-mile long LANSCE accelerator exist due to average beam intensities ranging from 1 milli-amp for H + beam to 100 micro-amps for the high intensity H - beam. Experimental programs are supplied with variable energy (maximum 800 MeV), pulse-width (maximum 1 msec), and pulse frequency (maximum 120 Hz) ion beams. The RSS includes personnel access control systems, beam spill monitoring systems, and beam current level limiting systems. It is a stand-alone system with redundant logic chains. A fault of the RSS will cause the insertion of fusible beam plugs in the accelerator low energy beam transport. The design philosophy, description, and operation of the RSS are described in this paper

Effective treatment of the brachial plexus syndrome in breast cancer patients by early detection and control of loco-regional metastases with radiation or systemic therapy

International Nuclear Information System (INIS)

Kamenova, B.; Braverman, A.S.; Schwartz, M.; Sohn, C.; Lange, C.; Efiom-Ekaha, D.; Rotman, M.; Yoon, H.

2009-01-01

In breast cancer (BC) patients the brachial plexus syndrome (BPS) has been reported to be due to loco-regional metastases or radiation plexopathy. Associated arm edema is considered more suggestive of the latter. Radiation therapy is the only effective treatment for BPS reported. The charts of all BC patients who presented to our clinic from 1982 to 2006 with homolateral arm pain and neurological deficits, without humerus, cervical spine, or brain metastases, were reviewed. There were 28 patients fulfilling these criteria for BPS. Supraclavicular, axillary or chest wall metastases developed synchronously with the BPS in 26 patients; in 21 they were recurrences, found 6-94 months (median 34 months) after primary BC treatment, while in 5 others they were progressing inoperable primary tumors and nodes. Arm edema first occurred at the same time as loco-regional metastases in 19 patients. Treatment for the BPS was administered to 22 patients; it was directed at their loco-regional metastases. The BPS was initially treated with radiation (8 patients) or chemo- or endocrine therapy (14 patients); 19 (86%) had partial or complete remission of pain and neurologic deficits, with an 8-month median duration. The BPS in BC patients is due to loco-regional metastases and is often associated with arm edema. Chemo- or endocrine therapy induced the remission of pain and deficits as frequently as radiation therapy. (author)

Design of a wireless radiation telemetry system

Energy Technology Data Exchange (ETDEWEB)

Chiang, H H [Chung Yuan Christian Coll. of Science and Engineering, Chung-Li, Taiwan; Chang, J K

1976-12-01

The wireless radiation telemetry system can be operated in all seasons. It is designed for the measurement of radiation intensities up to millicurie order at a distance of 1 Km or less. Its measuring error is +-0.01 percent deviation from the count rate of the typical direct-detecting instrument with the same radiation source. This error indicates that the accuracy is high enough for practical uses. This system is cheaper and more flexible, comparing with the corresponding cable facility. The line-of-sight transmission distance can be longer if the transmitting power is appropriately increased. All pulse type radiation detectors can be used as the input section of this system.

Mesenchymal stem cells favour healing of the cutaneous radiation syndrome; Les cellules souches mesenchymateuses favorisent la cicatrisation des lesions cutanees radio induites

Energy Technology Data Exchange (ETDEWEB)

Francois, S.; Mouiseddine, M.; Mathieu, N.; Semont, A.; Monti, P.; Dudoignon, N.; Sache, A.; Boutarfa, A.; Thierry, D.; Voisin, P.; Gourmelon, P.; Chapel, A. [IRSN, Dir. de radioprotection de l' Homme, 92 - Fontenay-aux-Roses (France)

2006-10-15

It has been suggested that human Mesenchymal Stem Cells (hMSC) could be used to repair numerous injured tissues. We have studied the potential use of hMSC in order to limit radiation-induced skin lesions. Immuno-deficient NOD/SCID mice were locally irradiated to the leg (30 Gy, dose rate 2.7 Gy/mn) using a {sup 60} Co source in order to induce a severe skin lesion. Cultured bone marrow hMSC were delivered intravenously to the mice. The irradiated skin samples were studied for the presence of the human cells, the severity of the lesions and the healing process. Macroscopic analysis and histology results showed that the lesions were evolving to a less severe degree of radiation dermatitis following hMSC transplant when compared to irradiated non-transplanted controls. Clinical scores for the studied skin parameters of treated mice were significantly improved. A faster healing was observed when compared to untreated mouse. Immuno-histology and Polymerase Chain reaction (PCR) analysis provided evidence that the human cells were found in the irradiated area. These results suggest a possible use of hMSC for the treatment of the early phase of the cutaneous radiation syndrome. A successful transplant of stem cells and subsequent reduction in radiation-induced complication may open the road to completely new strategies in cutaneous radiation syndrome therapy. (authors)

Radiation damping in focusing-dominated systems

International Nuclear Information System (INIS)

Huang, Zhirong; Chen, Pisin; Ruth, R.D.

1995-01-01

A quasi-classical method is developed to calculate the radiation damping of a relativistic particle in a straight, continuous focusing system. In one limiting case where the pitch angle of the particle θ p is much larger than the radiation opening angle 1/γ, the radiation power spectrum is similar to synchrotron radiation and the relative damping rate of the transverse action is proportional to the relative energy loss rate. In the other limiting case where θ p much-lt 1/γ, the radiation is dipole in nature and the relative damping rate of the transverse action is energy-independent and is much faster than the relative energy rate. Quantum excitation to the transverse action is absent in this focusing channel. These results can be extended to bent systems provided that the focusing field dominates over the bending field

Regulatory System of Radiation Protection in Taiwan

International Nuclear Information System (INIS)

Tang, F. T.; Huang, C. C.

2004-01-01

After the radioactive contaminated buildings incident occurred in Taiwan in 1993, the competent authority for radiation protection the Atomic Energy Council (AEC) started to review the structured problem of radiation protection regulatory system. Through several years' investigation and study, the AEC has improved two important tools in radiation protection regulatory system, i.e., control regulations and actual practice, and made them more rigorous and efficient. This paper will make a brief introduction of the efforts that Taiwan has made in this respect. Taiwan's radiation protection control was based on the Atomic Energy Law promulgated in 1968, but the control idea and authorization scope were not sufficient to appropriately respond to the highly developed economy and democracy in Taiwan. After several years' legislative process, the Ionizing Radiation Protection Law (IRP Law) was promulgated and entered into force on February 1, 2003. This IRP Law specifically emphasizes categorized risk management of radiation sources, establishment of personnel licenses and training system, enhancement of public safety control, and implementation of quality assurance program for medical exposure. The Legislative Yuan (Congress) fully authorized the competent authority to establish various technological control regulations according to control necessity without prior review by the Legislative Yuan in advance. As to the penalties of the violations of the IRP Law, the AEC adopts high-rated administrative fines and applies the Criminal Law to those who seriously contaminate the environment. In actual practice, the AEC has constructed a Radiation Protection Control Information System compatible with the IRP Law that fully combines the functions of computers and Internet. The information of facility operators who own radiation sources, radiation protection specialists, and operating personnel are entered into this system, starting from the submission of application of the

Manual for medical problems of radiation protection

International Nuclear Information System (INIS)

Anon.

1979-01-01

The manual deals comprehensively and topically with the theoretical and practical fundamentals of radiation protection of the population considering the present knowledge in the fields of radiobiology and radiation protection medicine. The subject is covered under the following headings: (1) physics of ionizing radiations, (2) biological radiation effects, (3) the acute radiation syndrome, (4) medical treatment of the acute radiation syndrome, (5) combined radiation injuries, and (6) prophylaxis and therapy of injuries caused by fission products of nuclear explosions. The book is of interest to medical doctors, medical scientists, and students in medicine who have to acquire special knowledge in the field of radiation protection and it is of value as a reference book in daily routine

Liver late effects of ionizing radiation; Effets tardifs des radiations sur le foie

Energy Technology Data Exchange (ETDEWEB)

Mornex, F.; Ramuz, O. [Centre Hospitalier Universitaire Lyon-Sud, 69 - Pierre-Benite (France); Gerard, F. [Laboratoire Marcel-Merieux, 69 - Lyon (France); Van Houtte, P. [Institut Bordet, Brussels (Belgium)

1997-12-01

Until recently, the liver was classified as a radioresistant organ, although it is in fact highly radiosensitive. The realization that the whole liver could be treated safety only with low doses of radiation led to the conclusion that radiation therapy had an extremely limited role in the treatment of intrahepatic malignancies. A resurgence of interest has been observed with the advent of conformal radiotherapy and the introduction of bone marrow transplantation with total body irradiation. The radiation-induced liver disease, often called radiation hepatitis, is a syndrome characterized by the development of anicteric ascites, approximately 2 weeks to 4 months after hepatic irradiation. Immediate tolerance is generally surprisingly good, and the subacute radiation injury is followed by a complete asymptomatic healing, although the late lesions may be associated with signs of chronic radiation hepatitis. Radiation hepatitis must be distinguished from chemo-radiation-induced-hepatitis occurring in patients undergoing bone marrow transplantation and total body irradiation. Both syndromes demonstrate the same pathological lesion: veno-occlusive disease. The main treatment for radiation hepatitis is diuretics, although soma advocate steroids for severe cases. (authors)

Care of radiation accidents

International Nuclear Information System (INIS)

Renz, K.

1983-01-01

The small probability of a serious radiation accident happening dispenses neither the plants where radiation exposure occurs nor the employers' liability insurance associations from their obligation to make provision for such cases. On the other hand, the efforts involved in such preventive measures must be kept within reasonable limits. As a result of these considerations a concept for taking care of radiation accidents was developed that is based on already existing institutions. The most attention was demanded by questions of organization, logistics, communication and information. The syndrome appearing after acute whole-body irradiation is known. This syndrome in its different stages and the relative therapeutic measures form the basis for the organization of the care of radiation accidents. (orig./MG) [de

Success Factors of European Syndromic Surveillance Systems: A Worked Example of Applying Qualitative Comparative Analysis.

Science.gov (United States)

Ziemann, Alexandra; Fouillet, Anne; Brand, Helmut; Krafft, Thomas

2016-01-01

Syndromic surveillance aims at augmenting traditional public health surveillance with timely information. To gain a head start, it mainly analyses existing data such as from web searches or patient records. Despite the setup of many syndromic surveillance systems, there is still much doubt about the benefit of the approach. There are diverse interactions between performance indicators such as timeliness and various system characteristics. This makes the performance assessment of syndromic surveillance systems a complex endeavour. We assessed if the comparison of several syndromic surveillance systems through Qualitative Comparative Analysis helps to evaluate performance and identify key success factors. We compiled case-based, mixed data on performance and characteristics of 19 syndromic surveillance systems in Europe from scientific and grey literature and from site visits. We identified success factors by applying crisp-set Qualitative Comparative Analysis. We focused on two main areas of syndromic surveillance application: seasonal influenza surveillance and situational awareness during different types of potentially health threatening events. We found that syndromic surveillance systems might detect the onset or peak of seasonal influenza earlier if they analyse non-clinical data sources. Timely situational awareness during different types of events is supported by an automated syndromic surveillance system capable of analysing multiple syndromes. To our surprise, the analysis of multiple data sources was no key success factor for situational awareness. We suggest to consider these key success factors when designing or further developing syndromic surveillance systems. Qualitative Comparative Analysis helped interpreting complex, mixed data on small-N cases and resulted in concrete and practically relevant findings.

Integrative radiation systems biology

International Nuclear Information System (INIS)

Unger, Kristian

2014-01-01

Maximisation of the ratio of normal tissue preservation and tumour cell reduction is the main concept of radiotherapy alone or combined with chemo-, immuno- or biologically targeted therapy. The foremost parameter influencing this ratio is radiation sensitivity and its modulation towards a more efficient killing of tumour cells and a better preservation of normal tissue at the same time is the overall aim of modern therapy schemas. Nevertheless, this requires a deep understanding of the molecular mechanisms of radiation sensitivity in order to identify its key players as potential therapeutic targets. Moreover, the success of conventional approaches that tried to statistically associate altered radiation sensitivity with any molecular phenotype such as gene expression proofed to be somewhat limited since the number of clinically used targets is rather sparse. However, currently a paradigm shift is taking place from pure frequentistic association analysis to the rather holistic systems biology approach that seeks to mathematically model the system to be investigated and to allow the prediction of an altered phenotype as the function of one single or a signature of biomarkers. Integrative systems biology also considers the data from different molecular levels such as the genome, transcriptome or proteome in order to partially or fully comprehend the causal chain of molecular mechanisms. An example for the application of this concept currently carried out at the Clinical Cooperation Group “Personalized Radiotherapy in Head and Neck Cancer” of the Helmholtz-Zentrum München and the LMU Munich is described. This review article strives for providing a compact overview on the state of the art of systems biology, its actual challenges, potential applications, chances and limitations in radiation oncology research working towards improved personalised therapy concepts using this relatively new methodology

Strategies for Discovery of Small Molecule Radiation Protectors and Radiation Mitigators

Directory of Open Access Journals (Sweden)

Joel S Greenberger

2012-01-01

Full Text Available Mitochondrial targeted radiation damage protectors (delivered prior to irradiation and mitigators (delivered after irradiation, but before the appearance of symptoms associated with radiation syndrome have been a recent focus in drug discovery for 1 normal tissue radiation protection during fractionated radiotherapy, and 2 radiation terrorism counter measures. Several categories of such molecules have been discovered: nitroxide-linked hybrid molecules, including GS-nitroxide, GS-nitric oxide synthase inhibitors, p53/mdm2/mdm4 inhibitors, and pharmaceutical agents including inhibitors of the phosphoinositide-3-kinase pathway and the anti-seizure medicine, carbamazepine. Evaluation of potential new irradiation dose modifying molecules to protect normal tissue includes: clonagenic radiation survival curves; assays for apoptosis and DNA repair, and irradiation-induced depletion of antioxidant stores. Studies of organ specific radioprotection and in total body irradiation-induced hematopoietic syndrome in the mouse model for protection/mitigation facilitate rational means by which to move candidate small molecule drugs along the drug discovery pipeline into clinical development.

Eaton-Lambert syndrome with small cell carcinoma of the lung. A case with a favorable clinical course through chemotherapy and radiation

Energy Technology Data Exchange (ETDEWEB)

Matsushita, Shigeki; Hanyu, Norinao; Ichiyoshi, Takeo; Yanagisawa, Nobuo

1987-04-01

A case of Eaton-Lambert syndrome with small cell carcinoma of the lung responding favorably to chemotherapy and radiation was described. The patient, 56-year-old man, began to feel weakness of the upper limbs in 1982 (age 52). His condition deteriorated gradually, followed by weakness of the lower limbs, dysphagia and bilateral ptosis. He was admitted to our hospital in Janualy 1984. We started radiation therapy for the lung mass and his neurological findings improved slightly. In June 1984, he complained of pain in the left elbow accompanied by increased ptosis and weakness in the limbs. The biopsy of left elbow lymphnode revealed the metastasis of intermediate cell type small cell carcinoma of the lung, and the diagnosis of Eaton-Lambert syndrome was confirmed. Metastases were also found at the right parietal bone and cervical lymphnode. We started a combination chemotherapy consisting of ACNU, vincristine, methotrexate and cyclophosphamide, adding prophylactic irradiation to the cranium and metastatic regions. After treatment, the metastases disappeared completely and no abnormal findings were found except for decreased tendon reflexes of the upper limbs. Post-treatment electromyography showed marked reduction of waxing and post-tetanic facilitation. We have intermittently continued a combination chemotherapy for consolidation. The patient is living well 21 months after the distant metastases became apparent, and is showing marked improvement of Eaton-Lambert syndrome through chemotherapy and radiation. We propose that anti-neoplastic treatment is the first choice for the treatment of Eaton-Lambert syndorame associated with small cell carcinoma of long. (J.P.N.).

Development of environment radiation database management system

Energy Technology Data Exchange (ETDEWEB)

Kang, Jong Gyu; Chung, Chang Hwa; Ryu, Chan Ho; Lee, Jin Yeong; Kim, Dong Hui; Lee, Hun Sun [Daeduk College, Taejon (Korea, Republic of)

1999-03-15

In this development, we constructed a database for efficient data processing and operating of radiation-environment related data. Se developed the source documents retrieval system and the current status printing system that supports a radiation environment dta collection, pre-processing and analysis. And, we designed and implemented the user interfaces and DB access routines based on WWW service policies on KINS Intranet. It is expected that the developed system, which organizes the information related to environmental radiation data systematically can be utilize for the accurate interpretation, analysis and evaluation.

Development of environment radiation database management system

International Nuclear Information System (INIS)

Kang, Jong Gyu; Chung, Chang Hwa; Ryu, Chan Ho; Lee, Jin Yeong; Kim, Dong Hui; Lee, Hun Sun

1999-03-01

In this development, we constructed a database for efficient data processing and operating of radiation-environment related data. Se developed the source documents retrieval system and the current status printing system that supports a radiation environment dta collection, pre-processing and analysis. And, we designed and implemented the user interfaces and DB access routines based on WWW service policies on KINS Intranet. It is expected that the developed system, which organizes the information related to environmental radiation data systematically can be utilize for the accurate interpretation, analysis and evaluation

Radiation toxins: molecular mechanisms of action and radiomimetic properties .

Science.gov (United States)

Popov, Dmitri; Maliev, Vecheslav

Introduction: Acute Radiation Disease (ARD) or Acute Radiation Syndromes (ARS) were defined as a toxic poisonous with development of the acute pathological processes in irradi-ated animals: systemic inflammatory response syndrome(SIRS), toxic multiple organ injury (TMOI), toxic multiple organ dysfunction syndromes (TMOD), toxic multiple organ failure (TMOF). However, the nature of radiation toxins, their mechanisms of formation, molecular structure, and mechanism of actions remain uncertain. Moderate and high doses of radiation induce apoptotic necrosis of radiosensitive cells with formation of Radiation Toxins and in-flammation development. Mild doses of radiation induce apoptosis or controlled programmed death of radiosensitive cells without Radiation Toxins formation and development of inflam-mation processes. Only radiation induced apoptotic necrosis initiates formation of Radiation Toxins(RT). Radiation Toxins are playing an important role as the trigger mechanisms for in-flammation development and cell lysis. The systemic inflammatory response syndrome after radiation involves an influence of various endogenous agents and mediators of inflammation such as bradykinin, histamine, serotonin and phospholipases activation, prostaglandins biosyn-thesis. Although, formation of non-specific toxins such as Reactive Oxygen Species (ROS) is an important pathological process at mild or high doses of radiation. Reactive Oxygen Species play an important role in molecules damage and development of peroxidation of lipids and pro-teins which are the structural parts of cell and mitochondrial membranes. ROS and bio-radicals induce damage of DNA and RNA and peroxidation of their molecules. But high doses of radia-tion, severe and extremely severe physiological stress, result in cells death by apoptotic necrosis and could be defined as the neuroimmune acute disease. Excitotoxicity is an important patho-logical mechanism which damages the central nervous system. We postulate that

Immune system investigations for radiation workers

International Nuclear Information System (INIS)

Obreja, Doina; Tulbure, Rodica; Marinescu, Irina

2001-01-01

During the last decade a great deal of attention has been paid to the research in the field of the immune system. Some important steps forward have been achieved in understanding the mechanisms of action and control of the immunologic responses. At the same time the concern for the possible health effects of exposure to ionizing radiation has considerably increased. On the purpose of the evaluation of the modifications induced by the ionizing radiation for radiation workers, we have applied the method of lymphocytic subpopulations, a method that evinces the proportions for the various subtypes of lymphocytes having different roles within the immune system. A number of 62 persons, employees of the Institute of Physics and Nuclear Engineering at Bucharest - Magurele were involved in this study. All radiation workers from 2 departments characterized by a high exposure to ionizing radiation were included, as follows: Group no. 1, consisting of 20 persons working at RWTS (Radioactive Waste Treating Station), thus presenting both external and internal irradiation; Group no. 2, consisting of 18 persons working at RPC (Radioactive Isotopes Preparing Center), a place where besides the radioactive contamination, the chemical risk was also present. The control group (consisting of 24 persons) was formed of employees from the same institute, with the difference that they were not radiation workers. For the statistical processing of the results the programs EPI INFO 6 and CIA were used. Significantly, when analyzing globally the lymphocytic modifications for TT and/or B lymphocytes (either increments or decrements when compared to the normal values), a noticeable statistical difference among the groups in terms of the frequency of the immune system modifications (Hi square test p=0.001) occurs. The results are in accordance to those in special literature mentioning age as a factor having a role in the appearance of the immune modifications. The obtained results indicate a

Design of online testing system of material radiation resistance

International Nuclear Information System (INIS)

Wan Junsheng; He Shengping; Gao Xinjun

2014-01-01

The capability of radiation resistance is important for some material used in some specifically engineering fields. It is the same principal applied in all existing test system that compares the performance parameter after radiation to evaluate material radiation resistance. A kind of new technique on test system of material radiation resistance is put forward in this paper. Experimentation shows that the online test system for material radiation resistance works well and has an extending application outlook. (authors)

A real-time radiation mapping system

International Nuclear Information System (INIS)

Scoggins, W.A.; VanEtten, D.M.

1988-01-01

A prototype of a real-time radiation mapping system, Ranger, was developed to respond to an accident involving the release of plutonium for the Department of Energy's Accident Response Group. In 1987 Ranger demonstrated that it can provide an efficient method of monitoring large areas of land for radioactive contamination. With the experience gained from the operation of the prototype, the external computer and software are being upgraded in order to obtain a fully operational system. The new system uses the prototype's commercially available line-of-sight microwave system for determining position and the same radiation detection instruments. The data obtained from the radiation detection instrument(s) are linked back to the external computer along with the relative position of the measurement through the ranging system. The data are displayed on a gridded map as colored circles and permanently stored in real-time. The different colors represent different contamination levels. Contours can be drawn using the permanently stored data. 4 figs

Ultraviolet Radiation in the Solar System

CERN Document Server

Vázquez, M

2006-01-01

UV radiation is an important part in the electromagnetic spectrum since the energy of the photons is great enough to produce important chemical reactions in the atmospheres of planets and satellites of our Solar System, thereby affecting the transmission of this radiation to the ground and its physical properties. Scientists have used different techniques (balloons and rockets) to access to the information contained in this radiation, but the pioneering of this new frontier has not been free of dangers. The Sun is our main source of UV radiation and its description occupies the first two chapters of the book. The Earth is the only known location where life exists in a planetary system and therefore where the interaction of living organism with UV radiation can be tested through different epochs and on distinct species. The development of the human technology has affected the natural shield of ozone that protects complex lifeforms against damaging UV irradiation. The formation of the ozone hole and its consequ...

Mobile phone-based syndromic surveillance system, Papua New Guinea.

Science.gov (United States)

Rosewell, Alexander; Ropa, Berry; Randall, Heather; Dagina, Rosheila; Hurim, Samuel; Bieb, Sibauk; Datta, Siddhartha; Ramamurthy, Sundar; Mola, Glen; Zwi, Anthony B; Ray, Pradeep; MacIntyre, C Raina

2013-11-01

The health care system in Papua New Guinea is fragile, and surveillance systems infrequently meet international standards. To strengthen outbreak identification, health authorities piloted a mobile phone-based syndromic surveillance system and used established frameworks to evaluate whether the system was meeting objectives. Stakeholder experience was investigated by using standardized questionnaires and focus groups. Nine sites reported data that included 7 outbreaks and 92 cases of acute watery diarrhea. The new system was more timely (2.4 vs. 84 days), complete (70% vs. 40%), and sensitive (95% vs. 26%) than existing systems. The system was simple, stable, useful, and acceptable; however, feedback and subnational involvement were weak. A simple syndromic surveillance system implemented in a fragile state enabled more timely, complete, and sensitive data reporting for disease risk assessment. Feedback and provincial involvement require improvement. Use of mobile phone technology might improve the timeliness and efficiency of public health surveillance.

Management information system applied to radiation protection services

International Nuclear Information System (INIS)

Grossi, Pablo Andrade; Souza, Leonardo Soares de; Figueiredo, Geraldo Magela; Figueiredo, Arthur

2013-01-01

An effective management information system based on technology, information and people is necessary to improve the safety on all processes and operations subjected to radiation risks. The complex and multisource information flux from all radiation protection activities on nuclear organizations requires a robust tool/system to highlight the strengths and weaknesses and identify behaviors and trends on the activities requiring radiation protection programs. Those organized and processed data are useful to reach a successful management and to support the human decision-making on nuclear organization. This paper presents recent improvements on a management information system based on the radiation protection directives and regulations from Brazilian regulatory body. This radiation protection control system is applied to any radiation protection services and research institutes subjected to Brazilian nuclear regulation and is a powerful tool for continuous management, not only indicating how the health and safety activities are going, but why they are not going as well as planned showing up the critical points. (author)

Management information system applied to radiation protection services

Energy Technology Data Exchange (ETDEWEB)

Grossi, Pablo Andrade; Souza, Leonardo Soares de; Figueiredo, Geraldo Magela; Figueiredo, Arthur, E-mail: pabloag@cdtn.br, E-mail: lss@cdtn.br, E-mail: gmf@cdtn.br, E-mail: arthurqof@gmail.com [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)

2013-07-01

An effective management information system based on technology, information and people is necessary to improve the safety on all processes and operations subjected to radiation risks. The complex and multisource information flux from all radiation protection activities on nuclear organizations requires a robust tool/system to highlight the strengths and weaknesses and identify behaviors and trends on the activities requiring radiation protection programs. Those organized and processed data are useful to reach a successful management and to support the human decision-making on nuclear organization. This paper presents recent improvements on a management information system based on the radiation protection directives and regulations from Brazilian regulatory body. This radiation protection control system is applied to any radiation protection services and research institutes subjected to Brazilian nuclear regulation and is a powerful tool for continuous management, not only indicating how the health and safety activities are going, but why they are not going as well as planned showing up the critical points. (author)

Oral manifestations associated with systemic complications of prune belly syndrome.

Science.gov (United States)

Pessoa, Larissa; Galvão, Virgilio

2013-01-01

Prune belly syndrome (PBS) is a rare congenital malformation of unknown etiology characterized by congenital abnormalities including abdominal wall flaccidity, urinary tract alterations, and bilateral cryptorchidism. The incidence of the syndrome is between 1/35000 and 1/50000 live births and there is little information about the oral findings. The present case describes the oral manifestations of a 15-year-old boy diagnosed with PBS. The findings include enamel hypoplasia associated with generalized hypocalcemic dental lines. In the radiographic exam, pronounced demineralization of the trabecular bone of the jaws, loss of lamina dura in all the teeth, and discontinuity of the mandibular cortical bone were observed. Prune belly syndrome is a rare disease, whose clinical dental aspects are not pathognomonic of the syndrome. The comprehension of the systemic mechanism of PBS and its comorbidities enable an understanding of the systemic etiologic factors associated with oral manifestations. Copyright © 2013 Elsevier Inc. All rights reserved.

Integrated nuclear and radiation protection systems

International Nuclear Information System (INIS)

Oprea, I.; Oprea, M.; Stoica, V.; Cerga, V.; Pirvu, V.; Badea, E.

1993-01-01

A multifunctional radiation monitoring equipment, flexible and capable to meet virtually environmental radiation monitoring, activity measurement and computational requirements, for nuclear laboratories has been designed. It can be used as a radiation protection system, for radionuclide measurement in isotope laboratories, nuclear technology, health physics and nuclear medicine, nuclear power stations and nuclear industry. The equipment is able to measure, transmit and record gamma dose rate and isotope activities. Other parameters and functions are optionally available, such as: self-contained alarm level, system self-test, dose integrator, syringe volume calculation for a given dose corrected for decay, calibration factor, 99 Mo assays performing and background subtraction

γ-Tocotrienol as a Promising Countermeasure for Acute Radiation Syndrome: Current Status

Directory of Open Access Journals (Sweden)

Vijay K. Singh

2016-05-01

Full Text Available The hazard of ionizing radiation exposure due to nuclear accidents or terrorist attacks is ever increasing. Despite decades of research, still, there is a shortage of non-toxic, safe and effective medical countermeasures for radiological and nuclear emergency. To date, the U.S. Food and Drug Administration (U.S. FDA has approved only two growth factors, Neupogen (granulocyte colony-stimulating factor (G-CSF, filgrastim and Neulasta (PEGylated G-CSF, pegfilgrastim for the treatment of hematopoietic acute radiation syndrome (H-ARS following the Animal Efficacy Rule. Promising radioprotective efficacy results of γ-tocotrienol (GT3; a member of the vitamin E family in the mouse model encouraged its further evaluation in the nonhuman primate (NHP model. These studies demonstrated that GT3 significantly aided the recovery of radiation-induced neutropenia and thrombocytopenia compared to the vehicle controls; these results particularly significant after exposure to 5.8 or 6.5 Gray (Gy whole body γ-irradiation. The stimulatory effect of GT3 on neutrophils and thrombocytes (platelets was directly and positively correlated with dose; a 75 mg/kg dose was more effective compared to 37.5 mg/kg. GT3 was also effective against 6.5 Gy whole body γ-irradiation for improving neutrophils and thrombocytes. Moreover, a single administration of GT3 without any supportive care was equivalent, in terms of improving hematopoietic recovery, to multiple doses of Neupogen and two doses of Neulasta with full supportive care (including blood products in the NHP model. GT3 may serve as an ultimate radioprotector for use in humans, particularly for military personnel and first responders. In brief, GT3 is a promising radiation countermeasure that ought to be further developed for U.S. FDA approval for the ARS indication.

Mobile Phone–based Syndromic Surveillance System, Papua New Guinea

Science.gov (United States)

Ropa, Berry; Randall, Heather; Dagina, Rosheila; Hurim, Samuel; Bieb, Sibauk; Datta, Siddhartha; Ramamurthy, Sundar; Mola, Glen; Zwi, Anthony B.; Ray, Pradeep; MacIntyre, C. Raina

2013-01-01

The health care system in Papua New Guinea is fragile, and surveillance systems infrequently meet international standards. To strengthen outbreak identification, health authorities piloted a mobile phone–based syndromic surveillance system and used established frameworks to evaluate whether the system was meeting objectives. Stakeholder experience was investigated by using standardized questionnaires and focus groups. Nine sites reported data that included 7 outbreaks and 92 cases of acute watery diarrhea. The new system was more timely (2.4 vs. 84 days), complete (70% vs. 40%), and sensitive (95% vs. 26%) than existing systems. The system was simple, stable, useful, and acceptable; however, feedback and subnational involvement were weak. A simple syndromic surveillance system implemented in a fragile state enabled more timely, complete, and sensitive data reporting for disease risk assessment. Feedback and provincial involvement require improvement. Use of mobile phone technology might improve the timeliness and efficiency of public health surveillance. PMID:24188144

Radiotherapy of superior vena cava syndrome

International Nuclear Information System (INIS)

Kawanami, Shoko; Imada, Hajime; Terashima, Hiromi; Nakata, Hajime

1996-01-01

The records of 38 patients with superior vena cava syndrome (SVC syndrome) due to malignancy and who received radiation therapy were retrospectively reviewed. The majority were lung cancers, constituting 28 of the 38 cases (73.7%). All patients were treated with conventional radiation doses ranging from 20 to 70 Gy and good symptomatic response was observed in 31 cases (81.6% ). The response appeared within 1.7±0.9 weeks on average (3 days-4 weeks;, and performance status also improved in 50% of the patients. The median survival was 6.6 months. Long term survivors were seen mostly in patients with thymoma, and only one patient ever showed a recurrence of SVC syndrome. We conclude that radiotherapy can be an effective therapeutic modality for SVC syndrome and that it improves the quality of life in most patients. (author)

Developing a new syndromic surveillance system for the London 2012 Olympic and Paralympic Games.

Science.gov (United States)

Harcourt, S E; Fletcher, J; Loveridge, P; Bains, A; Morbey, R; Yeates, A; McCloskey, B; Smyth, B; Ibbotson, S; Smith, G E; Elliot, A J

2012-12-01

Syndromic surveillance is vital for monitoring public health during mass gatherings. The London 2012 Olympic and Paralympic Games represents a major challenge to health protection services and community surveillance. In response to this challenge the Health Protection Agency has developed a new syndromic surveillance system that monitors daily general practitioner out-of-hours and unscheduled care attendances. This new national system will fill a gap identified in the existing general practice-based syndromic surveillance systems by providing surveillance capability of general practice activity during evenings/nights, over weekends and public holidays. The system will complement and supplement the existing tele-health phone line, general practitioner and emergency department syndromic surveillance systems. This new national system will contribute to improving public health reassurance, especially to meet the challenges of the London 2012 Olympic and Paralympic Games.

Systemic Multiple Aneurysms Caused by Vascular Ehlers-Danlos Syndrome.

Science.gov (United States)

Gui, Xinyu; Li, Fangda; Wu, Lingeer; Zheng, Yuehong

2016-07-01

Systemic multiple aneurysms are rare and usually associated with collagen tissue disease, such as Ehlers-Danlos syndrome (EDS) or Marfan syndrome. In the present case, we describe a 39-year-old male patient with systemic multiple aneurysms and acute intraperitoneal hemorrhage who was clinically diagnosed with vascular EDS. Coil embolization of the distal segment of the common hepatic artery was performed, which resolved the patient's symptoms. With this case presentation, we aim to increase the awareness of vascular EDS among clinicians and emphasize the extreme fragility of the arteries in patients with vascular EDS. © The Author(s) 2016.

New type of radiation instrumentation system

International Nuclear Information System (INIS)

Matsuo, Keichi; Takaoka, Akira; Uranaka, Yasuo

2000-01-01

The Mitsubishi Electric Co., Ltd. developed a radiation instrumentation system introduced some recent techniques such as computation technique, network technique and so on into conventional radiation detection aiming at general market except power generation company. In a conventional system, a detector and an operation processing board was placed at a field and center, respectively, and a feeble pulse signal from the detector was transferred to the operation processing board. Then, on establishment of cables, detectors and operation processing board, it is essential to carry out engineering planning and field engineering conceiving on noise countermeasure. Noise resistance of the new type of radiation instrumentation system, not by adding operation processing function and network interface function into a detector unit in a field to transfer feeble signal, but by transferring testing result as a digital signal. And, noise removing function capable of selectively passing only signal pulse waveform from the detector to judge its signal waveform was also added to a detector unit in the field, to carry out a thoroughly removing noise. In addition, by connecting between each apparatus placed at the field with a network a system capable of reducing some cable engineering could be executed. Here were introduced on abstract of this new type of radiation instrumentation system and on noise removing function of its characteristics. (G.K.)

Radiographic imaging system for high energy radiation

International Nuclear Information System (INIS)

Barrett, H.H.

1976-01-01

A radiographic imaging system for high energy radiation utilizing a detector of such radiation and a mask having regions relatively transparent to such radiation interspersed among regions relatively opaque to such radiation is described. A relative motion is imparted between the mask and the detector, the detector providing a time varying signal in response to the incident radiation and in response to the relative motion. The time varying signal provides, with the aid of a decoder, an image of a source of such radiation

Radiographic imaging system for high energy radiation

International Nuclear Information System (INIS)

1975-01-01

A radiographic imaging system for high energy radiation is described utilizing a detector of such radiation and a mask having regions relatively transparent to such radiation and interspersed among regions relatively opaque to such radiation. A relative motion is imparted between the mask and the detector, the detector providing a time varying signal in response to the incident radiation and in response to the relative motion. The time varying signal provides, with the aid of a decoder, an image of a source of such radiation

[Intelligent systems tools in the diagnosis of acute coronary syndromes: A systemic review].

Science.gov (United States)

Sprockel, John; Tejeda, Miguel; Yate, José; Diaztagle, Juan; González, Enrique

2017-03-27

Acute myocardial infarction is the leading cause of non-communicable deaths worldwide. Its diagnosis is a highly complex task, for which modelling through automated methods has been attempted. A systematic review of the literature was performed on diagnostic tests that applied intelligent systems tools in the diagnosis of acute coronary syndromes. A systematic review of the literature is presented using Medline, Embase, Scopus, IEEE/IET Electronic Library, ISI Web of Science, Latindex and LILACS databases for articles that include the diagnostic evaluation of acute coronary syndromes using intelligent systems. The review process was conducted independently by 2 reviewers, and discrepancies were resolved through the participation of a third person. The operational characteristics of the studied tools were extracted. A total of 35 references met the inclusion criteria. In 22 (62.8%) cases, neural networks were used. In five studies, the performances of several intelligent systems tools were compared. Thirteen studies sought to perform diagnoses of all acute coronary syndromes, and in 22, only infarctions were studied. In 21 cases, clinical and electrocardiographic aspects were used as input data, and in 10, only electrocardiographic data were used. Most intelligent systems use the clinical context as a reference standard. High rates of diagnostic accuracy were found with better performance using neural networks and support vector machines, compared with statistical tools of pattern recognition and decision trees. Extensive evidence was found that shows that using intelligent systems tools achieves a greater degree of accuracy than some clinical algorithms or scales and, thus, should be considered appropriate tools for supporting diagnostic decisions of acute coronary syndromes. Copyright © 2017 Instituto Nacional de Cardiología Ignacio Chávez. Publicado por Masson Doyma México S.A. All rights reserved.

Radiation energy calibrating system and method

International Nuclear Information System (INIS)

Jacobson, A.F.

1980-01-01

A radiation energy calibrating system and method which uses a pair of calibrated detectors for measurements of radiation intensity from x-ray tubes for a non-invasive determination of the electrical characteristics; I.E., the tube potential and/or current

Radiation-sensitive genetically susceptible pediatric sub-populations

Energy Technology Data Exchange (ETDEWEB)

Kleinerman, Ruth A. [National Cancer Institute, NIH, DHHS, Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Rockville, MD (United States)

2009-02-15

Major advances in pediatric cancer treatment have resulted in substantial improvements in survival. However, concern has emerged about the late effects of cancer therapy, especially radiation-related second cancers. Studies of childhood cancer patients with inherited cancer syndromes can provide insights into the interaction between radiation and genetic susceptibility to multiple cancers. Children with retinoblastoma (Rb), neurofibromatosis type 1 (NF1), Li-Fraumeni syndrome (LFS), and nevoid basal cell carcinoma syndrome (NBCCS) are at substantial risk of developing radiation-related second and third cancers. A radiation dose-response for bone and soft-tissue sarcomas has been observed in hereditary Rb patients, with many of these cancers occurring in the radiation field. Studies of NF1 patients irradiated for optic pathway gliomas have reported increased risks of developing another cancer associated with radiotherapy. High relative risks for second and third cancers were observed for a cohort of 200 LFS family members, especially children, possibly related to radiotherapy. Children with NBCCS are very sensitive to radiation and develop multiple basal cell cancers in irradiated areas. Clinicians following these patients should be aware of their increased genetic susceptibility to multiple primary malignancies enhanced by sensitivity to ionizing radiation. (orig.)

Distributed Radiation Monitoring System for Linear Accelerators based on CAN Bus

CERN Document Server

Kozak, T; Napieralski, A

2010-01-01

Abstract—Gamma and neutron radiation is produced during the normal operation of linear accelerators like Free-Electron Laser in Hamburg (FLASH) or X-ray Free Electron Laser (X-FEL). Gamma radiation cause general degeneration of electronics devices and neutron fluence can be a reason of soft error in memories and microcontrollers. X-FEL accelerator will be built only in one tunnel, therefore most of electronic control systems will be placed in radiation environment. Exposing control systems to radiation may lead to many errors and unexpected failure of the whole accelerator system. Thus, the radiation monitoring system able to monitor radiation doses produced near controlling systems is crucial. Knowledge of produced radiation doses allows to detect errors caused by radiation, make plans of essential exchange of control systems and prevent accelerator from serious damages. The paper presents the project of radiation monitoring system able to monitor radiation environment in real time.

Radiation Shielding Systems Using Nanotechnology

Science.gov (United States)

Chen, Bin (Inventor); McKay, Christoper P. (Inventor)

2011-01-01

A system for shielding personnel and/or equipment from radiation particles. In one embodiment, a first substrate is connected to a first array or perpendicularly oriented metal-like fingers, and a second, electrically conducting substrate has an array of carbon nanostructure (CNS) fingers, coated with an electro-active polymer extending toward, but spaced apart from, the first substrate fingers. An electric current and electric charge discharge and dissipation system, connected to the second substrate, receives a current and/or voltage pulse initially generated when the first substrate receives incident radiation. In another embodiment, an array of CNSs is immersed in a first layer of hydrogen-rich polymers and in a second layer of metal-like material. In another embodiment, a one- or two-dimensional assembly of fibers containing CNSs embedded in a metal-like matrix serves as a radiation-protective fabric or body covering.

Manifestations of Gorlin-Goltz syndrome

DEFF Research Database (Denmark)

Larsen, Anne Kristine; Mikkelsen, Dorthe; Hertz, Jens Michael

2014-01-01

INTRODUCTION: Gorlin-Goltz syndrome is an uncommon hereditary condition caused by mutations in the PTCH1 gene causing a wide range of developmental abnormalities. Multiple basal cell carcinomas, palmoplantar pits and jaw cysts are cardinal features. Many clinicians are unfamiliar with the different...... manifestations and the fact that patients are especially sensitive to ionizing radiation. MATERIAL AND METHODS: This was a retrospective analysis of patients with Gorlin-Goltz syndrome seen at the Department of Dermatology and Allergy Centre or at Department of Plastic Surgery, Odense University Hospital...... families and none of these mutations had previously been described. CONCLUSION: The patient cohort illustrates classic and rare disease manifestations. It is necessary to remind clinicians that radiation therapy in Gorlin-Goltz syndrome is relatively contraindicated. Today, mutation analysis can be used...

Ultra violet radiation : effects on animals

International Nuclear Information System (INIS)

Stockdale, P.H.G.

1993-01-01

The paper deals with the evolutionary and historical events that have increased the susceptibility of certain genotypes of humanity and domestic animals to ultra violet radiation. Further it discusses the general effects of ultraviolet B (UVB) on vertebrates and then the clinical syndromes seen in such animals as a result of prolonged exposure to this form of radiation. Finally it gives anecdotal comments on evidence for changes in the immediately above types of disease and describes the need for a better recording system for these conditions so that these hypothetical changes could be effectively monitored. (author). 12 refs

Axial tomographic system for radiation diagnoses

International Nuclear Information System (INIS)

Crowther, T.J.

1977-01-01

The axial tomographic scanner consists of a source of hard radiation passing a fan shaped beam through a plane layer of the body under examination, a detector, and driving systems for the sequential displacement and rotation of the radiation source and the detector. The diagnosis is made by means of a data processing system offering extensive time overlap capability of the individual system functions. The data sets from transmission or absorption are processed in three independent subsystems, i.e., the scanning system, the processing system and the display system. The systems are made up of well-known modules, e.g., Nova 1200 or Eclipse 5200. Hence, as a result of the independent design of the data system, raw data will not be lost in case of faults in some subsystem. (DG) [de

Potential biological indicators of multi-organ damage: Application to radiation accident victims; Bio-indicateurs potentiels d'atteinte multi-organe: application au cas des victimes d'irradiation accidentelles

Energy Technology Data Exchange (ETDEWEB)

Bertho, J.M.; Souidi, M.; Gourmelon, P. [Institut de Radioprotection et de Surete Nucleaire (IRSN), Dir. de la Radioprotection de l' Homme 92 - Fontenay-aux-Roses (France)

2009-09-15

Accidental irradiations induce a complex pathological situation, difficult to assess and to treat. However, recent results describing new biological indicators of radiation-induced damages such as Flt3-ligand, citrulline and oxy-sterol concentration in the plasma, together with results obtained in large animal models of high dose irradiation, allowed a better understanding of pathophysiological mechanisms induced by uncontrolled irradiations. This conducted to leave the classical paradigm of the acute radiation syndrome, described as the association of three individual syndromes, the hematopoietic syndrome, the gastro-intestinal syndrome and the cerebrovascular syndrome, in favour of a multiple organ dysfunction syndrome, with the implication of other organs and systems. Follow-up of victims from two recent radiation accidents brings a confirmation of the usefulness of the newly described biological indicators, and also a partial confirmation of this new concept of a multiple organ dysfunction syndrome. (authors)

Automatic radiation measuring system connected with GPS

International Nuclear Information System (INIS)

Tanigaki, Minoru

2014-01-01

The most serious nuclear disaster in Japan has broken out at Fukushima Daiichi Nuclear Power Plant due to Great East Japan Earthquake. Prompt and exact mapping of the contamination is of great importance for radiation protection and for the environment restoration. We have developed radiation survey systems KURAMA and KURAMA-2 for rapid and exact measurement of radiation dose distribution. The system is composed of a mobile radiation monitor and the computer in office which is for the storage and visualization of the data. They are connected with internet and are operated for continuous radiation measurement while the monitor is moving. The mobile part consists of a survey meter, an interface to transform the output of the survey meter for the computer, a global positioning system, a computer to process the data for connecting to the network, and a mobile router. Thus they are effective for rapid mapping of the surface contamination. The operation and the performance of the equipment at the site are presented. (J.P.N.)

Radiation monitoring system for astronauts

International Nuclear Information System (INIS)

Thomson, I.; MacKay, G.; Ng, A.; Tomi, L.

1996-01-01

Astronauts in space are constantly under the bombardment of radiation particles from trapped electrons, and trapped proton. In addition, cosmic rays, while penetrating the spacecraft shell, generate secondary radiation of neutrons. As astronauts' stay in space is getting longer, the need for a real-time radiation monitoring device has become critical. Thermoluminescent dosemeter (TLD), used onboard both the MIR and the Space Transportation System (STS), cannot provide real-time dose reading. This paper describes a real-time direct read-out device, currently under development, which can measure skin, eye, and Blood Forming Organ (BFO) doses separately. (author)

Development of Nuclide Recognizing Prompt Radiation Distribution Monitoring System

Energy Technology Data Exchange (ETDEWEB)

Lee, Uk Jae; Yoo, Dong Han; Kim, Hee Reyoung [Ulsan National Institute of Science and Technology, Ulsan (Korea, Republic of)

2014-05-15

The geographic data such as latitude, longitude and map image can be obtained by using GPS and digital map. Radiation data can be acquired by detector. Finally simultaneous visibility system can be operated by using CDMA. Existing radiation distribution monitoring system is based on random generated data. However the radiation distribution monitoring system is developed. It is based on real detected data. Connection between the detector and laptop which are located at a site place is operated by using Bluetooth. CDMA is used to simulate visibility system between laptop in a site place and server PC in the control office. Real map image is taken from digital map. Finally radiation distribution contour map on the real map image can be shown by using MATLAB. 5 figures appear which shows natural, {sup 137}Cs, {sup 131}I, artificial and total radiation dose rate. So this system can be used in everywhere to check the distribution of radiation with geographic information.

Environmental radiation monitoring system with GPS (global positioning system)

International Nuclear Information System (INIS)

Komoto, Itsuro

2000-01-01

This system combines a radiation monitoring car with GPS and a data processor (personal computer). It distributes the position information acquired through GPS to the data such as measured environmental radiation dose rate and energy spectrum. It also displays and edits the data for each measuring position on a map. Transmitting the data to the power station through mobile phone enables plan managers to easily monitor the environmental radiation dose rate nearby and proper emergency monitoring. (author)

Radiation induced early onset of neuro-cognitive changes

International Nuclear Information System (INIS)

Kumar, Mayank; Haridas, Seenu; Gupta, Mamta; Trivedi, Richa; Khushu, Subhash; Manda, Kailash

2012-01-01

Exposure to ionizing radiations has been shown to cause many detrimental effects. Primarily, the effects observed are broadly classified into hematopoietic syndrome at lower doses, gastrointestinal syndrome and central nervous system dysfunctions at high doses. However, recent studies reported that even at lower doses, there is an effect seen on the nervous system which can be observed as a decline in cognitive abilities. This has been reported in patients undergoing radiotherapy. The cognitive decline, especially in young patients affects development and has been shown to persist for years after the therapy. Thus, the aim of this study was to study and consolidate the early effects of radiation exposure which result in behavioural alterations and cognitive decline. Since, radiation-induced early changes in behavioural functions are poorly understood, therefore, the present investigation aimed to conceptualize and design behavioural test batteries in order to systematically study the immediate alterations in behavioural function following irradiation with a-rays. The behavioural alterations were correlated to changes in the different area of brain like hippocampus, thalamus, hypothalamus and corpus callosum using Diffusion Tensor Imaging (DTI) studies. Present study reported profound changes in behaviour, as well as alterations in the morphology of the brain tissue as perceived by DTI, 48 hours after exposure to ionizing radiations. These changes need to be correlated and clarified further to understand the mechanisms behind the cognitive dysfunctions occurring immediately after radiation exposure as well as to find out a therapeutic window to counteract or reduce the effect of long term cognitive changes following irradiation. (author)

Radiation risks to the developing nervous system

International Nuclear Information System (INIS)

Kriegel, H.; Schmahl, W.; Stieve, F.E.; Gerber, G.B.

1986-01-01

A symposium dealing with 'Radiation Risks to the Developing Nervous System' held at Neuherberg, June 18-20, 1985 was organised by the Radiation Protection Programme of the Commission of the European Communities and the Gesellschaft fuer Strahlen- und Umweltforschung mbH. The proceedings of this symposium present up-to-date information on the development of the nervous system and the modifications caused by prenatal radiation there upon. A large part of the proceedings is devoted to the consequences of prenatal irradiation in experimental animals with respect to alterations in morphology, biochemistry and behaviour, to the influence of dose, dose rate and radiation quality and to the question whether damage of the brain can arise from a synergistic action of radiation together with other agents. Since animal models for damage to the human central nervous system have inherent short-comings due to the differences in structure, complexity and development it is discussed how experimental studies could be applied to the human situation. The most recent data on persons exposed in utero at Hiroshima and Nagasaki are reviewed. A round table discussion, published in full, analyses all this information with a view to radiation protection, and defines the areas where future studies are needed. Separate abstracts were prepared for papers in these proceedings. (orig./MG)

Evaluation of the impact of the urinary symptoms on quality of life of patients with painful bladder syndrome/chronic pelvic pain and radiation cystitis: EURCIS study.

Science.gov (United States)

Rapariz-González, M; Castro-Díaz, D; Mejía-Rendón, D

2014-05-01

To evaluate the impact of urinary symptoms of Painful Bladder/Pelvic Pain Syndrome and Radiation Cystitis (PBCPPS) on the Quality of Life, and self-esteem of the patient. An observational, multicenter, epidemiological and cross-sectional study was performed on patients with Painful Bladder/Chronic Pelvic Pain Syndrome and Radiation Cystitis. Data was recorded on severity of urinary symptoms and QoL impairment using the PUF Score. The patients evaluated the QoL deterioration grade through the King's Health Questionnaire (KHQ), and the level of their anxiety and self-esteem with the Goldberg's Anxiety Scale (GAS) and Rosenberg's Self-Esteem Scale (RSES), respectively. Post-hoc comparisons were performed between the results of the KHQ of this study and a sample of patients with urinary incontinence (UI). Results on RSES were analyzed with data from the general population and from patients with erectile dysfunction. A total of 530 cases, mostly female patients, who had been diagnosed with PBCPPS, were analyzed. High levels of deterioration in QoL were described: KHQ scores were significantly higher when compared with patients with UI (P<.01). Involvement of self-esteem was higher in patients with RC and men, who obtained scores similar to those of patients with erectile dysfunction. Patients with Painful Bladder Syndrome/Chronic Pelvic Pain Syndrome and Radiation Cystitis present high levels of anxiety, and significant reductions in both quality of life and self-esteem. Especially for men, this affectation is similar to that caused by erectile dysfunction. Copyright © 2013 AEU. Published by Elsevier Espana. All rights reserved.

RAM R-200 - A Portable Ruggedized Radiation Monitoring System

International Nuclear Information System (INIS)

Wengrowicz, U.; Mazor, T.; Assido, H.; Kadmon, Y.; Tirosh, D.; Shani, G.

1999-01-01

RAM R-200, a new generation of ruggedized portable radiation-monitoring systems, is presented. The system which is a result of interdisciplinary research, was developed at the NRCN in collaboration with Ben-Gurion University. It consists of RAM R-200 - a portable radiation meter, and a variety of external probes for wide range gamma radiation fields and beta-gamma contamination detection and measurement. The meter or each one of the external probes can be used as a portable system or a stand-alone radiation measurement station. All the system's components were specially designed to meet severe environmental conditions

21 CFR 892.5750 - Radionuclide radiation therapy system.

Science.gov (United States)

2010-04-01

... system. (a) Identification. A radionuclide radiation therapy system is a device intended to permit an... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Radionuclide radiation therapy system. 892.5750... patient's body. This generic type of device may include signal analysis and display equipment, patient and...

ROLE OF MRI IN EVALUATION OF MRKH SYNDROME

Directory of Open Access Journals (Sweden)

Lalitha Kumari

2015-11-01

Full Text Available : MRKH Syndrome is one of diverse spectrum of congenital mullerian duct anamolies ranging from complete absence to hypoplasia of uterus and upper 2/3rd of vagina owing to their embryological origin. This is the second most common cause of primary amennorhoea in young females who shows normal development of secondary sexual characters and endocrine profile with essential normal female phenotype & genotype (46 XX. Our study is to emphasis the role of MRI in diagnosis of this syndrome non-invasively without exposure to radiation. The excellent soft tissue anatomical details by MRI provides the diagnosis with accuracy along with information of adjacent viscera and other associated systemic anamolies.

Solar radiation for Mars power systems

Science.gov (United States)

Appelbaum, Joseph; Landis, Geoffrey A.

1991-01-01

Detailed information about the solar radiation characteristics on Mars are necessary for effective design of future planned solar energy systems operating on the surface of Mars. A procedure and solar radiation related data from which the diurnally and daily variation of the global, direct (or beam), and diffuse insolation on Mars are calculated, are presented. The radiation data are based on measured optical depth of the Martian atmosphere derived from images taken of the Sun with a special diode on the Viking Lander cameras; and computation based on multiple wavelength and multiple scattering of the solar radiation.

A computer system for occupational radiation exposure information

International Nuclear Information System (INIS)

Hunt, H.W.

1984-01-01

A computerized occupational radiation exposure information system has been developed to maintain records for contractors at the U.S. Department of Energy's (DOE) Hanford Site. The system also allows indexing and retrieval of three million documents from microfilm, thus significantly reducing storage needs and costs. The users are linked by display terminals to the data base permitting them instant access to dosemetry and other radiation exposure information. Personnel dosemeter and bioassay results, radiation training, respirator fittings, skin contaminations and other radiation occurrence records are included in the data base. The system yields immediate analysis of radiological exposures for operating management and health physics personnel, thereby releasing personnel to use their time more effectively

Examination system utilizing ionizing radiation and a flexible, miniature radiation detector probe

Science.gov (United States)

Majewski, Stanislaw; Kross, Brian J.; Zorn, Carl J.; Majewski, Lukasz A.

1996-01-01

An optimized examination system and method based on the Reverse Geometry X-Ray.RTM. (RGX.RTM.) radiography technique are presented. The examination system comprises a radiation source, at least one flexible, miniature radiation detector probe positioned in appropriate proximity to the object to be examined and to the radiation source with the object located between the source and the probe, a photodetector device attachable to an end of the miniature radiation probe, and a control unit integrated with a display device connected to the photodetector device. The miniature radiation detector probe comprises a scintillation element, a flexible light guide having a first end optically coupled to the scintillation element and having a second end attachable to the photodetector device, and an opaque, environmentally-resistant sheath surrounding the flexible light guide. The probe may be portable and insertable, or may be fixed in place within the object to be examined. An enclosed, flexible, liquid light guide is also presented, which comprises a thin-walled flexible tube, a liquid, preferably mineral oil, contained within the tube, a scintillation element located at a first end of the tube, closures located at both ends of the tube, and an opaque, environmentally-resistant sheath surrounding the flexible tube. The examination system and method have applications in non-destructive material testing for voids, cracks, and corrosion, and may be used in areas containing hazardous materials. In addition, the system and method have applications for medical and dental imaging.

Discussion on radiation protection system from ethical issues

International Nuclear Information System (INIS)

Li, Xutong; Guo, Qiuju

2002-01-01

This paper discussed the relationship between radiation protection system and ethical principle, viz. equity and efficiency. According to the authors' opinions, the main problem that the system of radiation protection facing now is the dose-limitation principle cannot incarnate the equity principle completely. Even though the distinguishing between practice and intervention is no other than solving the problem, but the scheme is not perfect still. Ethical issues should be given more attention and be more researched when we try to modify the radiation protection system today

A new system for radiation monitoring

International Nuclear Information System (INIS)

Toivonen, H.

1993-01-01

The Finnish authorities are acquiring a new radiation monitoring system enabling realtime transmission of information on the radiation situation. The system will also gather meteorological data and make predictions on the movements of a radioactive cloud. The data are stored in a database, from which they can be retrieved onto a user's workstation. Each user can get an overall picture of the current situation by viewing a set of files which are produced automatically by the system. Upon receiving notice of a hazard, the system contacts the paging devices of the officers on call. When the notice comes from a single station, the system automatically reads the measurement data of all stations within 50 kilometers. The system, development of which began in 1992, will be put to use early next year. (orig.)

Combined effects of radiation and trauma

Science.gov (United States)

Messerschmidt, Otfried

Injuries, caused by both whole-body irradiation and wounds or burns, have been relatively little studied. Possibly because many investigators think that these injuries are just modified radiation-induced diseases for which the same treatment principles are valid. Other authors had the impression that, for instance, the radiation burn trauma is a new kind of disease which differs significantly from either radiation syndrome alone or from burn disease. There are many experimental data on animals which suggest that the pathology of combined injuries differs significantly from that of radiation-induced disease or of thermal or mechanical traumas. Wounds or burns which, in general, do not cause septicaemia could become entrance ports for bacteria when animals are exposed to whole-body irradiation. Thrombocytopenia is the reason for hemorrhages in wounds. The susceptibility to shock is increased considerably in combined injuries and the formation of callus in the bone fractures is significantly delayed. The healing of wounds and burns in the initial phase of the radiation syndrome does not always differ from healing in the non-irradiated organism. However, a few days or weeks later very serious wound infections and hemorrhages can occur. The additional injuries almost always worsen the development and prognosis of radiation-induced disease. The recommended treatment for combined injuries will differ in many respects from the treatment of wounds and burns or the radiation syndrome.

Centralized environmental radiation monitoring system in JAERI

International Nuclear Information System (INIS)

Katagiri, H.; Kobalyashi, H.

1993-01-01

JAERI has continued the environmental radiation background survey and monitoring to ensure the safety of the peoples around the institute since one year before the first criticality of JRR-1 (Japan Research Reactor No.1) in August 1957. Air absorbed doses from β and γ radiation, α and β radioactivity in air and the radioactivities in environmental samples were the monitoring items. For the monitoring of β and γ radiation and α and β radioactivity in air, monitoring station and the centralized automatic environmental radiation monitoring system applying a computer were established as a new challenging monitoring system for nuclear facility, which was the first one not only in Japan but also in the would in 1960 and since then the system has been renewed two times (in 1973 and 1988) by introducing the latest technology in the fields of radiation detection and computer control at each stage. Present system renewed in 1988 was designed to prevent the interruption of monitoring due to computer troubles, communication troubles and power failures especially an instant voltage drop arisen from thunder by reflecting the experiences through the operation and maintenance of the former system. Dual telemeters whose power is constantly supplied via batteries (capable of 10 min monitoring after power failure) are equipped in the monitoring center to cope with telemeter troubles, which has operated successfully without any suspension being attributable to the power failures and telemeter troubles

Centralized environmental radiation monitoring system in JAERI

International Nuclear Information System (INIS)

Katagiri, Hiroshi; Kobayashi, Hideo

1993-03-01

Japan Atomic Energy Research Institute (JAERI) has continued the radiation background survey and environmental radiation monitoring to ensure the safety of the residents around the Institute. For the monitoring of β and γ radiations and α and β radioactivities in air, the centralized automatic environmental radiation monitoring system (EMS) applying a computer with monitoring stations (MS) was established. The system has been renewed twice in 1973 and 1988. In 1962, a new concept emergency environmental γ-ray monitoring system (MP) was begun to construct and completed in 1965 independent of EMS. The first renewal of the EMS was carried out by focusing on the rapid and synthetic judgement and estimation of the environmental impacts caused by radiation and radioactive materials due to the operation of nuclear facilities by centralizing the data measured at MS, MP, a meteorological station, stack monitors and drainage monitoring stations under the control of computer. Present system renewed in 1988 was designed to prevent the interruption of monitoring due to computer troubles, communication troubles and power failures especially an instant voltage drop caused by thunder by reflecting the experiences through the operation and maintenance of the former system. Dual telemeters whose power is constantly supplied via batteries (capable of 10 min. monitoring after power failure) are equipped in the monitoring center to cope with telemeter troubles, which has operated successfully without any suspension being attributable to the power failures and telemeter troubles. (J.P.N.)

Radiation safety systems at the NSLS

International Nuclear Information System (INIS)

Dickinson, T.

1987-04-01

This report describes design principles that were used to establish the radiation safety systems at the National Synchrotron Light Source. The author described existing safety systems and the history of partial system failures. 1 fig

Development of aerial gamma radiation survey system, 1

International Nuclear Information System (INIS)

Tsutsumi, Masahiro; Saito, Komei; Sakamoto, Ryuichi; Nagaoka, Toshi; Moriuchi, Shigeru

1986-05-01

JAERI has started to develop an aerial gamma radiation survey system by a helicopter in 1980. The development of measuring instruments, the experiments in the field of natural and artificial radiation sources, and the imaginary emergency survey at a real site, were executed. This report describes mainly about the hardware and software of this system. The system consists of gamma-ray measuring instruments with NaI(Tl) scintillation detectors, microwave positioning instruments, and a data processing system for postflight data. A foreign-made geological survey system is improved on for radiation measurements. For covering the wide radiation range, detectors of various shapes and sizes are prepared, from a large volume detector, DET-1024 - four 4'' x 4'' x 16'' crystals assembly - to a 2'' diameter x 2'' NaI(Tl) crystal. Radiation and position data are recorded on a magnetic tape, and computer-processed afterwards. Moreover, scene below flight courses and internal communication are recorded on video tape with the information of clock and position superimposed. In consequence of field experiments carried out five times, basic radiation data for evaluating airborne acquired data are accumulated, and flight survey procedures are established. As more practical use, a system has been produced more compactly and functionally. Exposure rates (> 1 mR/h), energy distribution spectra, and energy window counts are obtained for radiation data. Using the Spectrum-Dose Conversion Method, the accurate exposure rates are directly calculated from pulse height spectra. Numerical tables of G(E) function converting pulse height spectra into exposures are shown in this report. As regards the analysis of survey data, process codes have been completed with either large-computer or mini-computer. (author)

Progress report: 1996 Radiation Safety Systems Division

International Nuclear Information System (INIS)

Bhagwat, A.M.; Sharma, D.N.; Abani, M.C.; Mehta, S.K.

1997-01-01

The activities of Radiation Safety Systems Division include (i) development of specialised monitoring systems and radiation safety information network, (ii) radiation hazards control at the nuclear fuel cycle facilities, the radioisotope programmes at Bhabha Atomic Research Centre (BARC) and for the accelerators programme at BARC and Centre for Advanced Technology (CAT), Indore. The systems on which development and upgradation work was carried out during the year included aerial gamma spectrometer, automated environment monitor using railway network, radioisotope package monitor and air monitors for tritium and alpha active aerosols. Other R and D efforts at the division included assessment of risk for radiation exposures and evaluation of ICRP 60 recommendations in the Indian context, shielding evaluation and dosimetry for the new upcoming accelerator facilities and solid state nuclear track detector techniques for neutron measurements. The expertise of the divisional members was provided for 36 safety committees of BARC and Atomic Energy Regulatory Board (AERB). Twenty three publications were brought out during the year 1996. (author)

The effects of radiation on electronic systems

International Nuclear Information System (INIS)

Messenger, G.C.; Ash, M.S.

1986-01-01

This book is the first unified treatment of the analysis and design methods for protection of principally electronic systems from the deleterious effects of nuclear and electro-magnetic radiation. Coverage spans from a detailed description of the nuclear radiation sources to pertinent semiconductor physics, then to hardness assurance. This work combines the disciplines of solid state physics, semiconductor physics, circuit engineering, nuclear physics, together with electronics and electromagnetic theory into a book that can be used as a text with problems at the end of the majority of the chapters. Written by veterans in the field, the most significant feature of this book is its comprehensive treatment of the phenomena involved. This treatment includes the analysis and design of the effect of nuclear radiation on electronic systems from the experimental, theoretical, and engineering viewpoints. Unique pedagogical attempts are employed to make the material more understandable from the position of an enlightened engineering and scientific readership whose task is the design and analysis of radiation hardened electronic systems

Optical fiber-applied radiation detection system

International Nuclear Information System (INIS)

Nishiura, Ryuichi; Uranaka, Yasuo; Izumi, Nobuyuki

2001-01-01

A technique to measure radiation by using plastic scintillation fibers doped radiation fluorescent (scintillator) to plastic optical fiber for a radiation sensor, was developed. The technique contains some superiority such as high flexibility due to using fibers, relatively easy large area due to detecting portion of whole of fibers, and no electromagnetic noise effect due to optical radiation detection and signal transmission. Measurable to wide range of and continuous radiation distribution along optical fiber cable at a testing portion using scintillation fiber and flight time method, the optical fiber-applied radiation sensing system can effectively monitor space radiation dose or apparatus operation condition monitoring. And, a portable type scintillation optical fiber body surface pollution monitor can measure pollution concentration of radioactive materials attached onto body surface by arranging scintillation fiber processed to a plate with small size and flexibility around a man to be tested. Here were described on outline and fundamental properties of various application products using these plastic scintillation fiber. (G.K.)

Distributing radiation management system of nuclear power plants

International Nuclear Information System (INIS)

Mihoya, Eiichi; Akashi, Michio

1999-01-01

The importance of radiation management for nuclear facilities including nuclear power plants has increased as the general public understanding has progressed, and necessary information for management must be processed exactly and quickly. In nuclear power plants, radiation management is performed by each individual operation, and collected information is managed by the system of each operation. The distributing radiation management system has been developed aiming to use a general-purpose LAN and make quick and efficient use of information managed by individual operations. This paper describes the system configuration and functions. (author)

The criteria for metabolic syndrome and the national health screening and education system in Japan

Directory of Open Access Journals (Sweden)

Kazumasa Yamagishi

2017-01-01

Full Text Available Two major definitions of metabolic syndrome have been proposed. One focuses on the accumulation of risk factors, a measure used by the American Heart Association (AHA and the National Heart, Lung, and Blood Institute (NHLBI; the other focuses on abdominal obesity, a measure used by the International Diabetes Federation (IDF and the Japanese government. The latter definition takes waist circumference (WC into consideration as an obligatory component, whereas the former does not. In 2009, the IDF, NHLBI, AHA, and other organizations attempted to unify these criteria; as a result, WC is no longer an obligatory component of those systems, while it remains obligatory in the Japanese criteria. In 2008, a new Japanese cardiovascular screening and education system focused on metabolic syndrome was launched. People undergoing screening are classified into three groups according to the presence of abdominal obesity and the number of metabolic risk factors, and receive health educational support from insurers. This system has yielded several beneficial outcomes: the visibility of metabolic syndrome at the population level has drastically improved; preventive measures have been directed toward metabolic syndrome, which is expected to become more prevalent in future generations; and a post-screening education system has been established. However, several problems with the current system have been identified and are under debate. In this review, we discuss topics related to metabolic syndrome, including (1 the Japanese criteria for metabolic syndrome; (2 metabolic syndrome and the universal health screening and education system; and (3 recent debates about Japanese criteria for metabolic syndrome.

Radiation accidents

International Nuclear Information System (INIS)

Saenger, E.L.

1986-01-01

It is essential that emergency physicians understand ways to manage patients contaminated by radioactive materials and/or exposed to external radiation sources. Contamination accidents require careful surveys to identify the metabolic pathway of the radionuclides to guide prognosis and treatment. The level of treatment required will depend on careful surveys and meticulous decontamination. There is no specific therapy for the acute radiation syndrome. Prophylactic antibodies are desirable. For severely exposed patients treatment is similar to the supportive care given to patients undergoing organ transplantation. For high-dose extremity injury, no methods have been developed to reverse the fibrosing endarteritis that eventually leads to tissue death so frequently found with this type of injury. Although the Three Mile Island episode of March 1979 created tremendous public concern, there were no radiation injuries. The contamination outside the reactor building and the release of radioiodine were negligible. The accidental fuel element meltdown at Chernobyl, USSR, resulted in many cases of acute radiation syndrome. More than 100,000 people were exposed to high levels of radioactive fallout. The general principles outlined here are applicable to accidents of that degree of severity

21 CFR 892.5050 - Medical charged-particle radiation therapy system.

Science.gov (United States)

2010-04-01

...-particle radiation therapy system. (a) Identification. A medical charged-particle radiation therapy system... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Medical charged-particle radiation therapy system... equipment, patient and equipment supports, treatment planning computer programs, component parts, and...

Radiation myelopathy. Analysis of the clinical picture. Die Strahlenmyelopathie. Klinische Analyse des Krankheitsbildes

Energy Technology Data Exchange (ETDEWEB)

Berlit, P

1987-01-01

After a review of the world literature, the case histories of 43 patients with radiation myelopathy are analyzed. In 1 patient there was a radiation injury of the medulla oblongata, in 2, cervical, in 28, thoracic, and in 12, lumbosacral. In the medulla oblongata lesion an alternans syndrome resulted. The patients with cervical and thoracic radiation myelopathies presented with a Brown-Sequard syndrome, a spinalis anterior syndrome or a transversal syndrome with pyramidal and spinothalamic tract involvement as the most prominent signs. For this group the term 'pyramidal-spinothalamic radiation myelopathy' is proposed. In lumbosacral radiation lesions a pure anterior horn syndrome may lead to spinothalamic tract involvement and the development of a cauda conus syndrome. The clinical presentation of these cases suggests that the location of the radiation lesion is most likely the region of the conus medullaris. The most frequent initial symptom was dysesthesia; the patients complained of burning pain or a feeling of coldness. Usually the neurological deficits were progressive, in pyramidal-spinothalamic radiation myelopathy over 12 months in average, in lumbosacral radiation lesions up to 10 years. The latent period between the finish of radiation therapy and the first neurological signs was 8 months (median) in cervical and thoracic myelopathy and 33 months in lumbosacral lesions. For the entire group of 43 patients there was an inverse relationship between the radiation dose (ret) and the latent period. A positive relation could be demonstrated between the age of patients at the time of radiation therapy and the latent period. Patients simultaneously receiving cytostatic drugs presented after a longer latent period than the remaining group. With 17 figs.

Systemic lupus erythematosus and Wiskott-Aldrich syndrome in an Italian patient

NARCIS (Netherlands)

Monteferrante, G.; Giani, M.; van den Heuvel, M. C.

Systemic lupus erythematosus has not yet been associated with mutations in the Wiskott-Aldrich syndrome gene; moreover, the time courses of platelet number and size in patients with Wiskott-Aldrich syndrome are unknown. In this case, we present the time trends of platelet count and volume and the

Molecular basis of radiation syndrome

International Nuclear Information System (INIS)

Romantsev, E.F.; Blokhina, V.D.; Zhulanova, Z I.; Koshcheenko, N.N.; Nikol'skij, A.V.; Filippovich, I.V.

1984-01-01

The book is devoted to the analysis of the mechanism of action of ionizing radiation on the most important biochemical processes in the cells and tissues. The postirradiating disturbances of the metabolism of precursors of nucleic acids, biosynthesis of proteins, metabolism of prostaglandins and cyclic nucleotides were examined in detail. The biochemical mechanism of the interphase cell death was discussed. The analysis of the experimental facts about the effect of ionizing radiation with different dose rate upon the cell metabolism was made

[The changes in renin-angiotensin-aldosterone-system in different subtypes of Cushing's syndrome].

Science.gov (United States)

Cui, Jia; Dou, Jingtao; Yang, Guoqing; Zang, Li; Jin, Nan; Chen, Kang; Du, Jin; Gu, Weijun; Wang, Xianling; Yang, Lijuan; Lyu, Zhaohui; Ba, Jianming; Mu, Yiming; Lu, Juming; Li, Jiangyuan; Pan, Changyu

2015-07-01

Cushing's syndrome is a clinical condition resulting from chronic exposure to excess glucocorticoid. As a consequence, long-term hypercortisolism contributes significantly to the development of systemic disorders by direct and/or indirect effects. The present study was to analyze the changes of renin-angiotensin-aldosterone-system in different subtypes of Cushing's syndrome on the standard posture test. We retrospectively reviewed 150 patients with histologically confirmed Cushing's syndrome treated at the PLA General Hospital between 2002 and 2014. Among them, 128 patients were diagnosed as adreno-cortico-tropic-hormone (ACTH)-independent Cushing's syndrome, and 22 were ACTH-dependent Cushing's syndrome. All patients were undertaken the posture test. Plasma renin activity (PRA), angiotensin II, plasma aldosterone concertration (PAC) levels were measured before and after the test. Basal plasma PRA [0.5 (0.2,1.3)µg·L(-1)·h(-1), angiotensin II [(48.9±20.1) ng/L] and PAC [(285.0±128.1) pmol/L] levels were within the normal range in supine position. Compared with the subjects with ACTH-independent Cushing's syndrome, the basal PAC levels were higher in subjects with ACTH-dependent Cushing's syndrome [(348.0±130.4) pmol/L vs (274.2±125.0) pmol/L, PCushing's syndrome [(49.7±26.4)%] was significantly lower than that in those with ACTH-independent Cushing's syndrome [(81.2±69.3)%] upon upright posture stimulation (PCushing's syndrome was similar to that in normal control. The basal PAC level and its response to upright posture are differently associated with ACTH level in Cushing's syndrome.

The hematologist and radiation casualties.

Science.gov (United States)

Dainiak, Nicholas; Waselenko, Jamie K; Armitage, James O; MacVittie, Thomas J; Farese, Ann M

2003-01-01

Since the terrorist attack of September 11, 2001, preparation by the health care system for an act of terrorism has been mandated by leaders of governments. Scenarios for terrorist acts involving radioactive material have been identified, and approaches to management (based on past experience from atomic weapons detonations and radiation accidents) have been developed. Because of their experience in managing patients with profound cytopenia and/or marrow aplasia, hematologists will be asked to play a significant role in evaluating and treating victims of mass accidental or deliberate exposure to radiation. This review provides a framework for understanding how radiation levels are quantified, how radiation alters the function of hematopoietic (and nonhematopoietic) cells and tissues, and how victims receiving a significant radiation dose can be identified and managed. In Section I, Dr. Nicholas Dainiak reviews four components of the Acute Radiation Syndrome: the hematopoietic, neurovascular, gastrointestinal and cutaneous subsyndromes. Clinical signs and symptoms are discussed for exposed individuals at the time of initial presentation (the prodromal phase) and during their course of disease (the manifest illness). In Section II, he presents clinical and laboratory methods to assess radiation doses, including time to onset and severity of vomiting, rate of decline in absolute blood lymphocyte count and the appearance of chromosome aberrations such as dicentrics and ring forms. Potential scenarios of a radiation terrorist event are reviewed, and methods for initial clinical assessment, triage, and early management of the acute radiation syndrome and its component subsyndromes are summarized. In Section III, Dr. Jamie Waselenko reviews the hematopoietic syndrome, and presents guidelines for the use of cytokine therapy, antibiotics, and supportive care that have been developed by the Strategic National Pharmaceutical Stockpile Working Group. Results of preclinical and

Nonorganic Failure-to-Thrive Syndrome and the Family System.

Science.gov (United States)

Alderette, Paula; deGraffenried, Donald F.

1986-01-01

Argues that nonorganic failure-to-thrive syndrome (NFTT) in infants is the result of family disengagement--the family system's maladaptive style of interaction. Proposes a systems-based approach to diagnosis and to treatment, focusing on the process of disengagement and other interaction factors. (Author/ABB)

KERMA-based radiation dose management system for real-time patient dose measurement

Science.gov (United States)

Kim, Kyo-Tae; Heo, Ye-Ji; Oh, Kyung-Min; Nam, Sang-Hee; Kang, Sang-Sik; Park, Ji-Koon; Song, Yong-Keun; Park, Sung-Kwang

2016-07-01

Because systems that reduce radiation exposure during diagnostic procedures must be developed, significant time and financial resources have been invested in constructing radiation dose management systems. In the present study, the characteristics of an existing ionization-based system were compared to those of a system based on the kinetic energy released per unit mass (KERMA). Furthermore, the feasibility of using the KERMA-based system for patient radiation dose management was verified. The ionization-based system corrected the effects resulting from radiation parameter perturbations in general radiography whereas the KERMA-based system did not. Because of this difference, the KERMA-based radiation dose management system might overestimate the patient's radiation dose due to changes in the radiation conditions. Therefore, if a correction factor describing the correlation between the systems is applied to resolve this issue, then a radiation dose management system can be developed that will enable real-time measurement of the patient's radiation exposure and acquisition of diagnostic images.

Advances in radiation biology: Relative radiation sensitivities of human organ systems. Volume 12

International Nuclear Information System (INIS)

Lett, J.T.; Altman, K.I.; Ehmann, U.K.; Cox, A.B.

1987-01-01

This volume is a thematically focused issue of Advances in Radiation Biology. The topic surveyed is relative radiosensitivity of human organ systems. Topics considered include relative radiosensitivities of the thymus, spleen, and lymphohemopoietic systems; relative radiosensitivities of the small and large intestine; relative rediosensitivities of the oral cavity, larynx, pharynx, and esophagus; relative radiation sensitivity of the integumentary system; dose response of the epidermal; microvascular, and dermal populations; relative radiosensitivity of the human lung; relative radiosensitivity of fetal tissues; and tolerance of the central and peripheral nervous system to therapeutic irradiation

Advances in radiation biology: Relative radiation sensitivities of human organ systems. Volume 12

Energy Technology Data Exchange (ETDEWEB)

Lett, J.T.; Altman, K.I.; Ehmann, U.K.; Cox, A.B.

1987-01-01

This volume is a thematically focused issue of Advances in Radiation Biology. The topic surveyed is relative radiosensitivity of human organ systems. Topics considered include relative radiosensitivities of the thymus, spleen, and lymphohemopoietic systems; relative radiosensitivities of the small and large intestine; relative rediosensitivities of the oral cavity, larynx, pharynx, and esophagus; relative radiation sensitivity of the integumentary system; dose response of the epidermal; microvascular, and dermal populations; relative radiosensitivity of the human lung; relative radiosensitivity of fetal tissues; and tolerance of the central and peripheral nervous system to therapeutic irradiation.

Solid state radiation detector system

International Nuclear Information System (INIS)

1977-01-01

A solid state radiation flux detector system utilizes a detector element, consisting of a bar of semiconductor having electrical conductance of magnitude dependent upon the magnitude of photon and charged particle flux impinging thereon, and negative feedback circuitry for adjusting the current flow through a light emitting diode to facilitate the addition of optical flux, having a magnitude decreasing in proportion to any increase in the magnitude of radiation (e.g. x-ray) flux incident upon the detector element, whereby the conductance of the detector element is maintained essentially constant. The light emitting diode also illuminates a photodiode to generate a detector output having a stable, highly linear response with time and incident radiation flux changes

Study of the casting speedy radiation-detection system

International Nuclear Information System (INIS)

Tan Xiaochun; Huang Junqing; Shi Xianbei; Zhao Gang; Wang Liping

2001-01-01

The paper introduces the design of the launching speedy radiation-detection system. It consists of launcher, semiconductor detector, microprocessor and communicator. It can give the intensity, position, time of radiation. The paper discusses the function, composition, principle, speciality and technical problem of this system

Erasmus syndrome: Association of silicosis and systemic sclerosis

Directory of Open Access Journals (Sweden)

Reena K Sharma

2018-01-01

Full Text Available Silicosis is an inflammatory disease of the lung characterized by irreversible lung fibrosis which develops from prolonged pulmonary inhalation and retention of crystalline silica and immune reaction. It mainly appears as an occupational hazard in persons involved in stone-quarrying, mining, and sand blasting. Crystalline silica is not only known to be responsible for silicosis but also for other autoimmune diseases including systemic lupus erythematosus (SLE, rheumatoid arthritis (RA-Caplan syndrome, systemic sclerosis (SSc, and antineutrophil cytoplasmic antibody (ANCA-related vasculitis. Erasmus syndrome is the association of silica exposure and subsequent development of SSc. The limited numbers of cases reported in the literature were miners and only sporadically involved in other professionals. Here, we report a case of a 52 -year-old stone cutter who developed silicosis and SSc after 25 years of exposure.

Radiation-induced tumors of the nervous system

International Nuclear Information System (INIS)

Bernstein, M.; Laperriere, N.

1991-01-01

Therapeutic and nontherapeutic ionizing radiation has long been recognized as a putative carcinogenic agent, but the evidence that radiation causes tumors is circumstantial at worst and statistically significant at best. There are no distinct histological, biochemical, cytogenetic, or clinical criteria that can be used to determine if an individual tumor was caused directly by previous irradiation of the anatomic area. Additional supportive evidence for radiation-induced tumors includes a position correlation between radiation dose and tumor incidence (usually in the low dose range) and experimental induction of the same neoplasm in appropriate animal models. even if these criteria are fulfilled, coincidental development of a second tumor can never be discounted in an individual patient, particularly if there is an underlying diathesis to develop multiple tumors of different histology, such as in Recklinghausen's disease, or if there is an strong family history for the development of neoplastic disease. In this paper, the authors critically evaluate the available evidence to support the hypothesis that radiation induces tumors in the nervous system. The current concepts of radiation carcinogenesis are discussed and are followed by a discussion of animal data and clinical experience in humans. Finally, a brief discussion on treatment of radiation-induced nervous system tumors is presented

Prototype demonstration of radiation therapy planning code system

International Nuclear Information System (INIS)

Little, R.C.; Adams, K.J.; Estes, G.P.; Hughes, L.S. III; Waters, L.S.

1996-01-01

This is the final report of a one-year, Laboratory-Directed Research and Development project at the Los Alamos National Laboratory (LANL). Radiation therapy planning is the process by which a radiation oncologist plans a treatment protocol for a patient preparing to undergo radiation therapy. The objective is to develop a protocol that delivers sufficient radiation dose to the entire tumor volume, while minimizing dose to healthy tissue. Radiation therapy planning, as currently practiced in the field, suffers from inaccuracies made in modeling patient anatomy and radiation transport. This project investigated the ability to automatically model patient-specific, three-dimensional (3-D) geometries in advanced Los Alamos radiation transport codes (such as MCNP), and to efficiently generate accurate radiation dose profiles in these geometries via sophisticated physics modeling. Modem scientific visualization techniques were utilized. The long-term goal is that such a system could be used by a non-expert in a distributed computing environment to help plan the treatment protocol for any candidate radiation source. The improved accuracy offered by such a system promises increased efficacy and reduced costs for this important aspect of health care

Biological effects of radiation

International Nuclear Information System (INIS)

2013-01-01

This fourth chapter presents: cell structure and metabolism; radiation interaction with biological tissues; steps of the production of biological effect of radiation; radiosensitivity of tissues; classification of biological effects; reversibility, transmissivity and influence factors; pre-natal biological effects; biological effects in therapy and syndrome of acute irradiation

Clinical radiation diagnostics of shoulder joint impingement syndrome

International Nuclear Information System (INIS)

Litvin, Yu.P.; Logvinenko, V.V.

2014-01-01

46 patients about an impingement are investigated by a syndrome of a humeral joint. Among them men was 28 (60,9 %) the person, women 18 (39,1 %). Middle age of the surveyed has made 52,6 ± 2,0 year. The traditional roentgenography is executed to all patients, a spiral computer tomography - 5 (10,9 %), an ultrasonography - 44 (95,7 %), a magnetic resonance imaging - 11 (23,9 %). Operative treatment is spent 16 (34,8 %) by the patient. Direct radial symptoms are what specify an impingement of a syndrome of a humeral joint in the reasons, indirect - symptoms of an inflammation both degenerate and dystrophic changes of structures of area of a humeral joint which are involved in pathological process. The best results are given by complex radial research at which it is possible to find out direct and indirect symptoms a syndrome impingement

Real Time Wide Area Radiation Surveillance System

Science.gov (United States)

Biafore, M.

2012-04-01

We present the REWARD project, financed within the FP7 programme, theme SEC-2011.1.5-1 (Development of detection capabilities of difficult to detect radioactive sources and nuclear materials - Capability Project). Within this project, we propose a novel mobile system for real time, wide area radiation surveillance. The system is based on the integration of new miniaturized solid-state radiation sensors: a CdZnTe detector for gamma radiation and a high efficiency neutron detector based on novel silicon technologies. The sensing unit will include a wireless communication interface to send the data remotely to a monitoring base station which also uses a GPS system to calculate the position of the tag. The system will also incorporate middleware and high level software to provide web-service interfaces for the exchange of information, and that will offer top level functionalities as management of users, mobile tags and environment data and alarms, database storage and management and a web-based graphical user interface. Effort will be spent to ensure that the software is modular and re-usable across as many architectural levels as possible. Finally, an expert system will continuously analyze the information from the radiation sensor and correlate it with historical data from the tag location in order to generate an alarm when an abnormal situation is detected. The system will be useful for many different scenarios, including such lost radioactive sources and radioactive contamination. It will be possible to deploy in emergency units and in general in any type of mobile or static equipment. The sensing units will be highly portable thanks to their low size and low energy consumption. The complete system will be scalable in terms of complexity and cost and will offer very high precision on both the measurement and the location of the radiation. The modularity and flexibility of the system will allow for a realistic introduction to the market. Authorities may start with a

Electron Radiation Belts of the Solar System

Science.gov (United States)

Mauk, Barry; Fox, Nicola

To address the question of what factors dictate similarities and differences between radiation belts, we present comparisons between the electron radiation belt spectra of all five strongly magnetized planets within the solar system: Earth, Jupiter, Saturn, Uranus, and Neptune. We choose the highest intensity observed electron spectrum within each system (highest specifically near 1 MeV) and compare them against expectations based on the so-called Kennel-Petschek limit (KP; 1966) for each system. For evaluating the KP limit, we begin with the new relativis-tically correct formulation of Summers et al. (2009) but then add several refinements of our own. Specifically, we: 1) utilized a much more flexible analytic spectral shape that allows us to accurately fit observed radiation belt spectra; 2) adopt the point of view that the anisotropy parameter is not a free parameter but must take on a minimal value, as originally proposed by Kennel and Petschek (1966); and 3) examine the differential characteristics of the KP limit along the lines of what Schulz and Davidson (1988) performed for the non-relativistic formula-tion. We find that three factors limit the highest electron radiation belt intensities within solar system planetary magnetospheres: a) whistler mode interactions that limit spectral intensities to a differential Kennel-Petschek limit (3 planets); b) the absence of robust acceleration pro-cesses associated with injection dynamics (1 planet); and c) material interactions between the radiation particles and clouds of gas and dust (1 planet).

A utility perspective on radiation worker access control systems

International Nuclear Information System (INIS)

Watson, B.A.; Goff, T.E.

1984-01-01

Based on an evaluation of the current commercial Radiation Worker Access Control Software Systems, Baltimore Gas and Electric Company has elected to design and develop a site specific access control and accountability system for the Calvert Cliffs Nuclear Power Plant. The vendor provided systems allow for radiation worker access control based on training and external exposure records and authorizations. These systems do not afford internal exposure control until after bioassay measurements or maximum permissible concentration-hours are tabulated. The vendor provided systems allow for data trending for ALARA purposes, but each software package must be modified to meet site specific requirements. Unlike the commercial systems, the Calvert Cliffs Radiological Controls and Accountability System (RCAS) will provide radiation worker exposure control, both internal and external. The RCAS is designed to fulfill the requirements by integrating the existing Radiation Safety, Dosemetry, and Training data bases with a comprehensive radiological surveillance program. Prior to each worker's entry into the Radiological Control Area; his training and qualifications, radiation exposure history and authorization, will be compared with administrative controls, such as radiation work permits, and respiratory protection requirements and the radiological conditions in the work area. The RCAS, a computer based applied health physics access control system is described as it is presently configured for development. The mechanisms for enhancing worker internal and external exposure controls are discussed. Proposed data application to both the Calvert Cliffs ALARA and outage planning programs is included

Radiation detector system having heat pipe based cooling

Science.gov (United States)

Iwanczyk, Jan S.; Saveliev, Valeri D.; Barkan, Shaul

2006-10-31

A radiation detector system having a heat pipe based cooling. The radiation detector system includes a radiation detector thermally coupled to a thermo electric cooler (TEC). The TEC cools down the radiation detector, whereby heat is generated by the TEC. A heat removal device dissipates the heat generated by the TEC to surrounding environment. A heat pipe has a first end thermally coupled to the TEC to receive the heat generated by the TEC, and a second end thermally coupled to the heat removal device. The heat pipe transfers the heat generated by the TEC from the first end to the second end to be removed by the heat removal device.

Evaluation of mid- and long-term consequences, clinical and social performance in Chernobyl acute radiation syndrome patients in a multi-centre clinical follow-up study

International Nuclear Information System (INIS)

Weiss, M.; Fischer, B.; Fliedner, T.M.; Bebeshko, V.G.; Belyi, D.A.; Kovalenko, A.N.; Nadejina, N.M.; Galstian, I.A.

1996-01-01

Since the Chernobyl accident in 1986 nearly all survivors (n=199) of 237 patients with suspected acute radiation syndrome (ARS) underwent regular follow-up investigations in the scientific centres in Kiev and in Moscow. In a close collaboration with these centres we investigate the health status of this population in a five step approach. An integral part of this approach to patient evaluation and analysis of the mid- and long-term consequences of the Chernobyl accident is a 'Questionnaire for clinical, laboratory and functional follow-up of radiation-exposed persons', developed with these centres. Beyond this project we report as an interim some results of analyses performed by the scientific centers in Kiev and in Moscow about disorders of the cardiovascular system and the digestive tract, formation of cataract, generalized and local skin injuries and/or disorders as well as for a subpopulation (n=89) the Karnofsky performance score and working ability

Goldenhar syndrome and medulloblastoma: a coincidental association? The first case report.

Science.gov (United States)

Aizenbud, Dror; Shoham, Natasha V; Constantini, Shlomi; Nevo, Neta; Ben Arush, Myriam; Raz, Michal; Rachmiel, Adi; Goldsher, Dorit

2014-07-01

Features of Goldenhar syndrome include several craniofacial anomalies of structures derived from the first and second pharyngeal arches, as well as vertebral, cardiac and renal systems abnormalities. In addition, Goldenhar patients were reported to manifest a variety of central nervous system anomalies and several types of neoplasias. The first case of medulloblastoma in a patient with Goldenhar syndrome is presented here. There is no clear association between these two pathologies. We speculate that aberrant events during the migration of neural crest cells in early stages of development could be the basis of an association between medulloblastoma and Goldenhar syndrome. The case history suggests other possible etiological contributing factors to the development of medulloblastoma, such as patient's history of trauma and/or early childhood exposure to ionizing radiation. Copyright © 2013 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

Three-axis asymmetric radiation detector system

Science.gov (United States)

Martini, Mario Pierangelo; Gedcke, Dale A.; Raudorf, Thomas W.; Sangsingkeow, Pat

2000-01-01

A three-axis radiation detection system whose inner and outer electrodes are shaped and positioned so that the shortest path between any point on the inner electrode and the outer electrode is a different length whereby the rise time of a pulse derived from a detected radiation event can uniquely define the azimuthal and radial position of that event, and the outer electrode is divided into a plurality of segments in the longitudinal axial direction for locating the axial location of a radiation detection event occurring in the diode.

Cranial magnetic resonance imaging of wolfram (DIDMOAD) syndrome

International Nuclear Information System (INIS)

Pakdemirli, E.; Karabulut, N.; Bir, L.S.; Sermez, Y.

2005-01-01

Wolfram syndrome is a rare neurodegenerative disorder characterized by diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD). A wide spectrum of abnormalities of the central nervous system, urinary tract and endocrine glands is also observed. We report cranial MRI findings in a 32-year-old female patient with Wolfram syndrome. In addition to the classical features, including absence of the normal high signal of the neurohypophysis, atrophy of visual pathways, the brainstem, cerebellum and cerebral cortex, we observed bilateral hyperintensity on proton density- and T 2 - weighted images related to the optic radiations in the periventricular white matter of the temporal and parieto-occipital lobes, which may reflect gliosis pathologically Copyright (2005) Blackwell Publishing Asia Pty Ltd

GammaCam trademark radiation imaging system

International Nuclear Information System (INIS)

1998-02-01

GammaCam trademark, a gamma-ray imaging system manufactured by AIL System, Inc., would benefit a site that needs to locate radiation sources. It is capable of producing a two-dimensional image of a radiation field superimposed on a black and white visual image. Because the system can be positioned outside the radiologically controlled area, the radiation exposure to personnel is significantly reduced and extensive shielding is not required. This report covers the following topics: technology description; performance; technology applicability and alternatives; cost; regulatory and policy issues; and lessons learned. The demonstration of GammaCam trademark in December 1996 was part of the Large-Scale Demonstration Project (LSDP) whose objective is to select and demonstrate potentially beneficial technologies at the Argonne National Laboratory-East (ANL) Chicago Pile-5 Research Reactor (CP-5). The purpose of the LSDP is to demonstrate that by using innovative and improved decontamination and decommissioning (D and D) technologies from various sources, significant benefits can be achieved when compared to baseline D and D technologies

A local-area-network based radiation oncology microcomputer system

International Nuclear Information System (INIS)

Chu, W.K.; Taylor, T.K.; Kumar, P.P.; Imray, T.J.

1985-01-01

The application of computerized technology in the medical specialty of radiation oncology has gained wide acceptance in the past decade. Recognizing that most radiation oncology department personnel are familiar with computer operations and terminology, it appears reasonable to attempt to expand the computer's applications to other departmental activities, such as scheduling, record keeping, billing, treatment regimen and status, etc. Instead of sharing the processing capability available on the existent treatment minicomputer, the radiation oncology computer system is based upon a microcomputer local area network (LAN). The system was conceptualized in 1984 and completed in March 1985. This article outlines the LAN-based radiation oncology computer system

Radiation effects in IFMIF Li target diagnostic systems

International Nuclear Information System (INIS)

Molla, J.; Vila, R.; Shikama, T.; Horiike, H.; Simakov, S.; Ciotti, M.; Ibarra, A.

2009-01-01

Diagnostics for the lithium target will be crucial for the operation of IFMIF. Several parameters as the lithium temperature, target thickness or wave pattern must be monitored during operation. Radiation effects may produce malfunctioning in any of these diagnostics due to the exposure to high radiation fields. The main diagnostic systems proposed for the operation of IFMIF are reviewed in this paper from the point of view of radiation damage. The main tools for the assessment of the performance of these diagnostics are the neutronics calculations by using specialised codes and the information accumulated during the last decades on the radiation effects in functional materials, components and diagnostics for ITER. This analysis allows to conclude that the design of some of the diagnostic systems must be revised to assure the high availability required for the target system.

The Digestive System and Nutritional Considerations for Individuals with Rett Syndrome

Directory of Open Access Journals (Sweden)

Meir Lotan

2006-01-01

Full Text Available Rett syndrome (RS is a neurodevelopmental syndrome of genetic origin that mainly affects females. Individuals diagnosed with RS exhibit a variety of functional difficulties that impair their quality of life. One of the affected systems is the digestive system, where 74% of persons with RS have abnormal functioning. The affected digestive system causes this population to present an array of problems, such as gastroesophageal reflux (GER, constipation, and malnutrition, leading to failure to thrive (FTT, which resolves in reduced functional ability. Due to the severe effects of the dysfunctional digestive system of individuals with RS, this article will describe the problems common to this population, as well as propose some clinical suggestions for intervention. .

The Digestive System and Nutritional Considerations for Individuals with Rett Syndrome

Science.gov (United States)

Lotan, Meir; Zysman, Lilit

2006-01-01

Rett syndrome (RS) is a neurodevelopmental syndrome of genetic origin that mainly affects females. Individuals diagnosed with RS exhibit a variety of functional difficulties that impair their quality of life. One of the affected systems is the digestive system, where 74% of persons with RS have abnormal functioning. The affected digestive system causes this population to present an array of problems, such as gastroesophageal reflux (GER), constipation, and malnutrition, leading to failure to thrive (FTT), which resolves in reduced functional ability. Due to the severe effects of the dysfunctional digestive system of individuals with RS, this article will describe the problems common to this population, as well as propose some clinical suggestions for intervention. . PMID:17195872

Radiachromic: a radiation monitoring system

International Nuclear Information System (INIS)

Humpherys, K.C.; Kantz, A.D.

1977-01-01

Various plastic film materials have been utilized to measure radiation fields. The radiachromic materials have been found to have advantages in reproducibility, stability, equivalent response to electrons and gamma ray fields, dose rate dependence and negligible variation for most environmental parameters. A simple photometer has been developed for read-out. The physical and chemical properties of the total system are described. A standard radiachromic has been selected for application to radiation processing. This material has a dose range of 5 x 10 4 to 3 x 10 7 rads, no dose rate effects to above 4 x 10 14 R/sec, an equivalent response to electrons and gamma rays, shelf life of greater than one year. Other forms are also applicable to radiation processing. (author)

Characteristics Of Oral Condition Among Workers In The Field Of Radiation

International Nuclear Information System (INIS)

Sallam, R.A.I.

2012-01-01

We live in radioactive world. Radiation is permanently present through out the environment whether from natural and / or artificial sources. Natural sources contribute about four to five times as much as artificial ones; they could be in the form of cosmic radiation, rocks, natural radium, uranium and thorium. Artificial source could be from medical radiation sources, industrial uses and nuclear technologies. Ionizing radiation negative biological effect on living organisms depends on dose of radiation and duration of exposure. Prolonged exposure to radiation particularly ionizing radiation has adverse effects on human health and immunity leading to systemic diseases. Different tissues of the body respond differently to radiation, due to varying degrees of radio sensitivity. When an adult subject is irradiated over the entire body, various syndromes are manifested depending on the dose applied. The effects of radiation are characterized by the survival time the species and various stages of acute syndromes following the total body irradiation. These effects are deterministic types and have a threshold dose. The long term or late effects of radiation cause various syndromes long after the radiation exposure. These may appear after acute radiation syndrome subside following exposure to a single large dose or after exposure to many smaller doses over a period. The late effects may be somatic or genetic, depending on the respective cells involved. Somatic effects are seen in the form of carcinogenesis, life shortening, cataract genesis, and embryologic damage. On the other hand, genetic effects result in abnormalities in the offspring. Dental diseases don't differ from any other diseases as the environmental factors may moderate dental diseases from day to day (Van Haute and Green, 1974). Occupational disease of hard and soft oral structures is due to direct action of the occupational causative agent on the workers oral tissue, which is affected as part of systemic

Design of Kartini reactor radiation monitor system using lab view

International Nuclear Information System (INIS)

Adi Abimanyu; Jumari; Achmad Fahrul Aji; Muhammad Khoiri

2014-01-01

Kartini Reactor operation will result in radiation exposure. Gamma radiation exposure rate at the Kartini Reactor monitored by several radiation monitors (Ludlum) that integrate with the computer, so that the rate of radiation exposure is always monitored. Current monitoring system combines six radiation monitor in one computer monitor radiation, and monitoring performed by operators and supervisors to see how the radiation exposure rate measured in the area around the reactor core in a periodic time manually. This research will develop a system to monitor radiation exposure in Kartini reactor based ATMega8 micro controller for interface between radiation monitor and computer and also Graphical User Interface (GUI) develop using Lab view software that makes monitoring is easier and documented regularly. This system is testing by simulation, it is done by replacing the function of the radiation monitoring devices (Ludlum) in Kartini Reactor with computers that send serial data with the same format with a format that is sent by Ludlum. The results show that the interface system has the ability to operate in a range of baud rate 1,200 bps, 2,400 bps, 4,800 bps, 9,600 bps, 14,400 bps, 19,200 bps and 38,400 bps, with the ability to provide realtime information every 6 seconds and able to document the rate of exposure to radiation in the form of logbook. (author)

Exposed persons at the Chernobyl Atomic Power Station accident: acute radiation effects

International Nuclear Information System (INIS)

Gus'kova, A.K.; Baranov, A.E.; Barabanova, A.V.

1987-01-01

Observation made over 115 patients with acute radiation sickness due to exposure external γ- and β-rays confirmed high efficiency of the earlier proposed principles of prognostication of the degree of severity by clinical manifestations of the primary disease response and those of separate syndromes, using the methods of hematological and cytogenetic analyses. Out of 115 victims, 56 persons had radiation burns (RB), 17 intestinal syndrome (IS), 80 - oropharengeal syndrome (ORS), 7 - interstitial radiation pneumonitis (IRP). In thanatogenesis, of prime importance were: RB (more than 40% of the body surface) - 19 persons and IRP - 7 persons. A severe course of intestinal and oropharengeal syndromes was combined with other fatal manifestations of radiation injury. Early isolation of patients (2-4 stages), selective decontamination of the intestine, prescription of a wide spectrum antibiotics, antimycotic and antiviral drugs, as well as γ-globulin could practically remove the risk of the development of fatal infectious complications during a medullary andtransitory forms of radiation sickness

A methodological framework for the evaluation of syndromic surveillance systems: a case study of England.

Science.gov (United States)

Colón-González, Felipe J; Lake, Iain R; Morbey, Roger A; Elliot, Alex J; Pebody, Richard; Smith, Gillian E

2018-04-24

Syndromic surveillance complements traditional public health surveillance by collecting and analysing health indicators in near real time. The rationale of syndromic surveillance is that it may detect health threats faster than traditional surveillance systems permitting more timely, and hence potentially more effective public health action. The effectiveness of syndromic surveillance largely relies on the methods used to detect aberrations. Very few studies have evaluated the performance of syndromic surveillance systems and consequently little is known about the types of events that such systems can and cannot detect. We introduce a framework for the evaluation of syndromic surveillance systems that can be used in any setting based upon the use of simulated scenarios. For a range of scenarios this allows the time and probability of detection to be determined and uncertainty is fully incorporated. In addition, we demonstrate how such a framework can model the benefits of increases in the number of centres reporting syndromic data and also determine the minimum size of outbreaks that can or cannot be detected. Here, we demonstrate its utility using simulations of national influenza outbreaks and localised outbreaks of cryptosporidiosis. Influenza outbreaks are consistently detected with larger outbreaks being detected in a more timely manner. Small cryptosporidiosis outbreaks (framework constitutes a useful tool for public health emergency preparedness in multiple settings. The proposed framework allows the exhaustive evaluation of any syndromic surveillance system and constitutes a useful tool for emergency preparedness and response.

Development of radiation safety monitoring system at gamma greenhouse gamma facility

International Nuclear Information System (INIS)

Hairul Nizam Idris; Azimawati Ahmad, Ahmad Zaki Hussain; Ahmad Fairuz Mohd Nasir

2009-01-01

This paper is discussing about installation of radiation safety monitoring system at Gamma Greenhouse Gamma facility, Agrotechnology and Bioscience Division (BAB). This facility actually is an outdoor type irradiation facility, which first in Nuclear Malaysia and the only one in Malaysia. Source Cs-137 (801 Curie) was use as radiation source and it located at the centre of 30 metres diameter size of open irradiation area. The radiation measurement and monitoring system to be equipped in this facility were required the proper equipment and devices, specially purpose for application at outside of building. Research review, literature study and discussion with the equipment manufacturers was being carried out, in effort to identify the best system should be developed. Factors such as tropical climate, environment surrounding and security were considered during selecting the proper system. Since this facility involving with panoramic radiation type, several critical and strategic locations have been fixed with radiation detectors, up to the distance at 200 meter from the radiation source. Apart from that, this developed system also was built for capable to provide the online real-time reading (using internet). In general, it can be summarized that the radiation safety monitoring system for outdoor type irradiation facility was found much different and complex compared to the system for indoor type facility. Keyword: radiation monitoring, radiation safety, Gamma Greenhouse, outdoor irradiation facility, panoramic radiation. (Author)

Modernization of WWER-1000 radiation monitoring systems

Energy Technology Data Exchange (ETDEWEB)

Smith, T [General Atomics, San Diego, CA (United States)

1996-12-31

A modernization scheme of the radiation monitoring system for WWER-1000 is proposed. It has a purpose to comply with international standards and to reduce operational and maintenance cost by deleting obsolete components and reducing the number of detector channels. Detailed layouts of I/C system architecture, digital radiation monitoring system (DRAMS) architecture and LRP block diagram are presented. If planned and implemented properly, this program can provide cost savings by reducing time required to access and display data and maintenance cost by deleting obsolete parts and decreasing the number of detector channels. 3 figs.

Modernization of WWER-1000 radiation monitoring systems

International Nuclear Information System (INIS)

Smith, T.

1995-01-01

A modernization scheme of the radiation monitoring system for WWER-1000 is proposed. It has a purpose to comply with international standards and to reduce operational and maintenance cost by deleting obsolete components and reducing the number of detector channels. Detailed layouts of I/C system architecture, digital radiation monitoring system (DRAMS) architecture and LRP block diagram are presented. If planned and implemented properly, this program can provide cost savings by reducing time required to access and display data and maintenance cost by deleting obsolete parts and decreasing the number of detector channels. 3 figs

Terrestrial radiation effects in ULSI devices and electronic systems

CERN Document Server

Ibe, Eishi H

2014-01-01

A practical guide on how mathematical approaches can be used to analyze and control radiation effects in semiconductor devices within various environments Covers faults in ULSI devices to failures in electronic systems caused by a wide variety of radiation fields, including electrons, alpha -rays, muons, gamma rays, neutrons and heavy ions. Readers will learn the environmental radiation features at the ground or avionics altitude. Readers will also learn how to make numerical models from physical insight and what kind of mathematical approaches should be implemented to analyze the radiation effects. A wide variety of mitigation techniques against soft-errors are reviewed and discussed. The author shows how to model sophisticated radiation effects in condensed matter in order to quantify and control them. The book provides the reader with the knowledge on a wide variety of radiation fields and their effects on the electronic devices and systems. It explains how electronic systems including servers and rout...

Political problems in the system of radiation protection laws of Japan

International Nuclear Information System (INIS)

Nakagawa, Haruo

2008-01-01

The lack of hierarchy and multiple restrictions by the radiation protection laws in Japan, causes multiple dose records of individual and scattering dose records. To solve the problem, the National Radiation Dose Registration Systems was proposed already by Atomic Energy Commission about 40 years ago. But only one radiation dose registration system is partly effective, which was applied for workers in nuclear plants. This paper reports political problems in the system of radiation protection laws of Japan, and proposes the new national radiation dose registration systems which will be able to have a function of supplementation of quality assurance of radiation protection laws. (author)

21 CFR 892.5300 - Medical neutron radiation therapy system.

Science.gov (United States)

2010-04-01

... therapy system. (a) Identification. A medical neutron radiation therapy system is a device intended to... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Medical neutron radiation therapy system. 892.5300... analysis and display equipment, patient and equipment support, treatment planning computer programs...

Automated TLD system for gamma radiation monitoring

International Nuclear Information System (INIS)

Nyberg, P.C.; Ott, J.D.; Edmonds, C.M.; Hopper, J.L.

1979-01-01

A gamma radiation monitoring system utilizing a commercially available TLD reader and unique microcomputer control has been built to assess the external radiation exposure to the resident population near a nuclear weapons testing facility. Maximum use of the microcomputer was made to increase the efficiency of data acquisition, transmission, and preparation, and to reduce operational costs. The system was tested for conformance with an applicable national standard for TLD's used in environmental measurements

The All Terrain Bio nano Gear for Space Radiation Detection System

International Nuclear Information System (INIS)

Ummat, Ajay; Mavroidis, Constantinos

2007-01-01

This paper discusses about the relevance of detecting space radiations which are very harmful and pose numerous health issues for astronauts. There are many ways to detect radiations, but we present a non-invasive way of detecting them in real-time while an astronaut is in the mission. All Terrain Bio-nano (ATB) gear system is one such concept where we propose to detect various levels of space radiations depending on their intensity and warn the astronaut of probable biological damage. A basic framework for radiation detection system which utilizes bio-nano machines is discussed. This radiation detection system is termed as 'radiation-responsive molecular assembly' (RMA) for the detection of space radiations. Our objective is to create a device which could detect space radiations by creating an environment equivalent to human cells within its structure and bio-chemically sensing the effects induced therein. For creating such an environment and further bio-chemically sensing space radiations bio-nano systems could be potentially used. These bio-nano systems could interact with radiations and signal based on the intensity of the radiations their relative biological effectiveness. Based on the energy and kind of radiation encountered, a matrix of signals has to be created which corresponds to a particular biological effect. The key advantage of such a design is its ability to interact with the radiation at e molecular scale; characterize its intensity based on energy deposition and relate it to the relative biological effectiveness based on the correspondence established through molecular structures and bond strengths of the bio-nano system

Evaluation of Syndromic Surveillance Systems in 6 US State and Local Health Departments.

Science.gov (United States)

Thomas, Mathew J; Yoon, Paula W; Collins, James M; Davidson, Arthur J; Mac Kenzie, William R

Evaluating public health surveillance systems is critical to ensuring that conditions of public health importance are appropriately monitored. Our objectives were to qualitatively evaluate 6 state and local health departments that were early adopters of syndromic surveillance in order to (1) understand the characteristics and current uses, (2) identify the most and least useful syndromes to monitor, (3) gauge the utility for early warning and outbreak detection, and (4) assess how syndromic surveillance impacted their daily decision making. We adapted evaluation guidelines from the Centers for Disease Control and Prevention and gathered input from the Centers for Disease Control and Prevention subject matter experts in public health surveillance to develop a questionnaire. We interviewed staff members from a convenience sample of 6 local and state health departments with syndromic surveillance programs that had been in operation for more than 10 years. Three of the 6 interviewees provided an example of using syndromic surveillance to identify an outbreak (ie, cluster of foodborne illness in 1 jurisdiction) or detect a surge in cases for seasonal conditions (eg, influenza in 2 jurisdictions) prior to traditional, disease-specific systems. Although all interviewees noted that syndromic surveillance has not been routinely useful or efficient for early outbreak detection or case finding in their jurisdictions, all agreed that the information can be used to improve their understanding of dynamic disease control environments and conditions (eg, situational awareness) in their communities. In the jurisdictions studied, syndromic surveillance may be useful for monitoring the spread and intensity of large outbreaks of disease, especially influenza; enhancing public health awareness of mass gatherings and natural disasters; and assessing new, otherwise unmonitored conditions when real-time alternatives are unavailable. Future studies should explore opportunities to

Development of lightweight radiators for lunar based power systems

International Nuclear Information System (INIS)

Juhasz, A.J.; Bloomfield, H.S.

1994-05-01

This report discusses application of a new lightweight carbon-carbon (C-C) space radiator technology developed under the NASA Civil-Space Technology Initiative (CSTI) High Capacity Power Program to a 20 kWe lunar based power system. This system comprises a nuclear (SP-100 derivative) heat source, a Closed Brayton Cycle (CBC) power conversion unit with heat rejection by means of a plane radiator. The new radiator concept is based on a C-C composite heat pipe with integrally woven fins and a thin walled metallic liner for containment of the working fluid. Using measured areal specific mass values (1.5 kg/m2) for flat plate radiators, comparative CBC power system mass and performance calculations show significant advantages if conventional heat pipes for space radiators are replaced by the new C-C heat pipe technology

Nuclear radiation in water

International Nuclear Information System (INIS)

Abrams, H.L.

1989-01-01

The manifestations of acute radiation sickness in the post-nuclear attack period must be recognized and understood in order to apply therapeutic measure appropriately. The syndromes observed-hematopoietic, gastrointestinal, central nervous system-are dose dependent and vary in the degree of patient impairment and lethality. Estimates of mortality and morbidity following a massive exchange vary profoundly, depending on the targeting scenarios, the modes employed, and the meteorologic conditions anticipated. Even the LD-50 dose remain the subject of controversy. Using a US Government model of such an exchange, an estimated 23 million survivors would have radiation sickness, frequently complicated by trauma and burns. Among these survivors, an overriding consideration will be the presence and extent of infection, associated with alterations in the immune system, malnutrition, dehydration, exposure and hardship. Triage and treatment will be extraordinarily complex, requiring patient relocation, massive fluid replacement, antibiotics, a sterile environment , and many other measures. Massive disparities between supply and demand for physicians, nurses, other health workers, hospital beds, supplies and equipment, antibiotics, and other pharmaceutical agents will render a coherent physician response virtually impossible. Such disparities will be compounded by the destruction of transport systems and intolerably high radiation levels in many areas. If it is true that the meliorative efforts of physicians in post-attack radiation damage will be incapable of addressing this massive health care problem meaningfully, then clearly their most effective role is to prevent the threat from materializing. (authors)

RENIN ANGIOTENSIN SYSTEM GENE POLYMORPHISMS IN CHILDREN WITH NEPHROTIC SYNDROM

Directory of Open Access Journals (Sweden)

Zh.P. Sharnova

2006-01-01

Full Text Available To investigate the role of the reninangiotensin system genes polymorphisms in develop and progression of nephrotic syndrom (NS in children we determined the genotypes of angiotensin converting enzyme (ACE, angiotensinogen (AGT and angiotensin ii receptor (ATII-R of 1 type in 80 russian children with ns including and 15 children with chronic renal failure (CRF. Genotype frequencies did not differ between patients with ns and controls (n = 165. The distribution of ace, AGT and ATII-R 1 type genotypes was similar among ns sub groups, such as focal segmental glomerulosclerosis (FSGS (n = 18, steroid-sensitive nephrotic syndrome (n = 32, nephrotic syndrome with hypertension and hemoturia (n = 22 and with control group. When ns subjects with CRF (n = 15 were compared with control, the prevalence of ace DD genotype was significantly higher (47% VS 21%; χ2 = 4,44; p < 0,05. Our results indicate that the DD genotype ace may be a factor of risk for the dеvеlopment of progressive renal impairment in the children with nephrotic syndrome. The analysis of treatment's effect with inhibitor of ace in groups patients with steroid resistant NS (SRNS demonstrated decreasing of renoprotective effect of this drugs in patients with id and dd genotypes com? Pared with ii genotype: the degree of blood pressure, proteinuria and the rate of glomerular filtration decrease was significantly lower (55,46 ± 9,25 VS 92,74 ± 25; р < 0,05 in these patients.Key words: nephrotic syndrom, chronic renal failure, polymorphism of genes, renin-angiotensin system.

Significance of grafting in radiation curing reactions. Comparison of ionising radiation and UV systems

International Nuclear Information System (INIS)

Zilic, E.; Ng, L.; Viengkhou, V.; Garnett, J.L.

1998-01-01

Full text: Radiation curing is now an accepted commercial technology where both ionising radiation (electron beam) and ultra violet light (UV) sources are used. Grafting is essentially the copolymerisation of a monomer/oligomer to a backbone polymer whereas curing is the rapid polymerisation of a monomer/oligomer mixture onto the surface of the substrate. There is no time scale theoretically associated with grafting processes which can occur in minutes or hours whereas curing reactions are usually very rapid, occurring within a fraction of a second. An important difference between grafting and curing is the nature of the bonding occurring in each process. In grafting covalent carbon-carbon bonds are formed, whereas in curing, bonding usually involves weaker Van der Waals or London dispersion forces. The bonding properties of the systems are important in determining their use commercially. Thus the possibility that concurrent grafting during curing could occur in a system is important since if present, grafting would not only minimise delamination of the coated product but could also, in some circumstances, render difficulties recycling of the finished product especially if it were cellulosic. Hence the conditions for observing the occurrence of concurrent grafting during radiation curing are important. In the present paper, this problem has been studied by examining the effect that the components used in radiation curing exert on a typical reaction. Instead of electron beam sources, the spent fuel element facility at Lucas Heights is used to simulate such ionising radiation sources. The model system utilised is the grafting of a typical methacrylate to cellulose. This is the generic chemistry used in curing systems. The effect of typical additives from curing systems including polyfunctional monomer and oligomers in the grafting reactions have been studied. The ionising radiation results have been compared with analogous data from UV experiments. The significance

Radiation early warning system

International Nuclear Information System (INIS)

Schmitzer, C.; Kloesch, W.; Stadtmann, H.

1993-01-01

A prototype station for a Radiation Early Warning Network has been designed and set up at the Austrian Research Centre Seibersdorf. This unit was developed to measure all relevant parameters necessary to detect and track radioactive contamination at an early stage. The station consists of the following components: Radiation measuring channel for ambient gamma dose rate. Meteorological measurement channels for air temperature and humidity, wind direction and wind speed, and precipitation. Data processing and storage unit. The system is capable of unattended operation and data acquisition even under adverse environmental conditions. Connection to a central processing platform may be achieved via leased line, dial up over public switched telephone network (PSTN), or radio-frequency transmission. The remote station will continue acquiring and storing data for at least a month, even if the communications link is broken. Multiple stations can be combined to form a network, providing detailed information about radiological and meteorological data at each site. Thus increased ambient radiation levels may be discovered, tracked, and forecasted based on calculations using current and local weather data

A critical review of the system of radiation protection

International Nuclear Information System (INIS)

2000-01-01

Our modern, information society is increasingly interested in transparency and participation in many aspects of government, and this is particularly true in areas involving public health and environmental protection. Radiation protection is no exception to this trend. Scientific rationale that was once sufficient to explain radiation protection theory and practice is no longer adequate. The need to address and communicate theory, practice and the decision-making process to a wider audience has given rise to numerous debates and led the radiation protection community to revisit the framework of the system of radiation protection. The very fundamentals of the system of radiation protection continue to be questioned in a healthy fashion, and many aspects have been identified which could better serve stakeholders given some additional thought in the light of modern societal needs. This report is the summary of the NEA's first reflections in this area, and describes those aspects of the current international system of radiation protection that could be improved. Suggested directions for improvement are provided. (author)

Method and circuit for stabilizing conversion gain of radiation detectors of a radiation detection system

International Nuclear Information System (INIS)

Stoub, E.W.

1986-01-01

A method is described for calibrating the gain of an array of radiation detectors of a radiation detection system comprising the steps of: (a) measuring in parallel for each radiation detector using a predetermined calibration point the energy map status, thereby obtaining an energy response vector whose elements correspond to the individual output of each radiation detector, each predetermined calibration point being a prescribed location corresponding to one of the radiation detectors; (b) multiplying that energy response vector with a predetermined deconvolution matrix, the deconvolution matrix being the inversion of a contribution matrix containing matrix elements C/sub IJ/, each such matrix element C/sub IJ/ of the contribution matrix representing the relative contribution level of a radiation detector j of the detection system for a point radiation source placed at a location i, thereby obtaining a gain vector product for the radiation detectors; (c) adjusting the gains of the radiation detectors with respect to the gain vector product such that a unity gain vector is essentially obtained; (d) measuring again the energy map status according to step (a); and (e) if the energy map status fails to essentially produce a unity gain vector repeat steps (a) to (d) until the energy map status substantially corresponds to unity

Metrology for γ-radiation spectrometry in a radiation monitoring system

International Nuclear Information System (INIS)

Khaikovich, I.M.; Shevrygin, O.N.; Fominykh, V.I.

1993-01-01

The rapid measurement of the characteristics of radionuclides is a priority when utilizing nuclear energy because of the needs of environmental conservation. This is particularly the case for long-lived nuclear-fuel fission products, 137,137 Cs, 144 Ce, 60 Co, etc., which as a rule are sources of high-energy γ-radiation. These can be measured by γ-ray spectrometry using scintillation or semiconductor devices. When choosing the metrological models, the starting points are the real characteristics of the distribution of the radionuclides in the soil (rock) and the need to estimate their surface activity and the reserves per unit area, i.e., the parameters from which one can estimate the influence of the radioactivity on nature and can decide the use of land areas. The methodology and the calculations presented show that a single metrological system for radiation monitoring can be constructed using multichannel geophysical radiometers (gamma spectrometers) while relying on a system of initial standard samples of small size. Such a metrological system at present provides all the necessary initial means for measuring the effective γ-radiation surface activity of 137,134 Cs and the mass fraction of the natural radioactive elements. Using these initial means of measurement, surveyed areas in the Leningrad and Tula provinces have been certified as State standard samples in terms of the eight parameters: the surface contamination activity of 137,134 Cs, the reserves of these per unit area, the mass fraction of the natural radioactive elements (potassium, uranium and thorium), the power of the equivalent (exposed) γ-radiation dose at a height of 1 m above the surface. It is intended to use the certified metrological surveyed areas to provide traceability and the required measurement accuracy when studying the contamination in European territories resulting from the accident at the Chernobyl nuclear power station

System integration for radiation records

International Nuclear Information System (INIS)

Lawson, B.J.; Farrell, L.; Meacham, C.; Tapio, J.

1994-01-01

System integration is the process where through networking and/or software development, necessary business information is available in a common computing environment. System integration is becoming an important objective for many businesses. System integration can improve productivity and efficiency, reduce redundant stored information and errors, and improve availability of information. This paper will discuss the information flow in a radiation health environment, and how system integration can help. Information handled includes external dosimetry and internal dosimetry. The paper will focus on an ORACLE based system integration software product

Health protection of radiation workers

International Nuclear Information System (INIS)

Norwood, W.D.

1975-01-01

This textbook is addressed to all those concerned with the protection of radiation workers. It provides full coverage of the implications of radiation in exposed workers, and, after a chapter outlining, in simple terms, the basic facts about radiation, deals with measurement of ionising radiation; radiation dosimetry; effectiveness of absorbed dose; general biological effects of ionising radiation; somatic effects of radiation; the acute radiation syndrome; other somatic effects; hereditary effects; radiation protection standards and regulations; radiation protection; medical supervision of radiation workers; general methods of diagnosis and treatment; metabolism and health problems of some radioisotopes; plutonium and other transuranium elements; radiation accidents; emergency plans and medical care; atomic power plants; medico-legal problems

Emergency response and radiation monitoring systems in Russian regions

International Nuclear Information System (INIS)

Arutyunyan, R.; Osipiyants, I.; Kiselev, V.; Ogar, K; Gavrilov, S.

2008-01-01

Full text: Preparedness of the emergency response system to elimination of radiation incidents and accidents is one of the most important elements of ensuring safe operation of nuclear power facilities. Routine activities on prevention of emergency situations along with adequate, efficient and opportune response actions are the key factors reducing the risks of adverse effects on population and environment. Both high engineering level and multiformity of the nuclear branch facilities make special demands on establishment of response system activities to eventual emergency situations. First and foremost, while resolving sophisticated engineering and scientific problems emerging during the emergency response process, one needs a powerful scientific and technical support system.The emergency response system established in the past decade in Russian nuclear branch provides a high efficiency of response activities due to the use of scientific and engineering potential and experience of the involved institutions. In Russia the responsibility for population protection is imposed on regional authority. So regional emergence response system should include up-to-date tools of radiation monitoring and infrastructure. That's why new activities on development of radiation monitoring and emergency response system were started in the regions of Russia. The main directions of these activities are: 1) Modernization of the existing and setting-up new facility and territorial automatic radiation monitoring systems, including mobile radiation surveillance kits; 2) Establishment of the Regional Crisis Centres and Crisis Centres of nuclear and radiation hazardous facilities; 3) Setting up communication systems for transfer, acquisition, processing, storage and presentation of data for participants of emergency response at the facility, regional and federal levels; 4) Development of software and hardware systems for expert support of decision-making on protection of personnel, population

System for radiation emergency medicine. Activities of tertiary radiation emergency hospitals

International Nuclear Information System (INIS)

Kamiya, Kenji; Tanigawa, Koichi; Hosoi, Yoshio

2011-01-01

Japanese system for radiation emergency medicine is primarily built up by Cabinet Nuclear Safety Commission in 2001 based on previous Tokai JCO Accident (1999) and is composed from the primary, secondary and tertiary medical organizations. This paper describes mainly about roles and actions of the tertiary facilities at Fukushima Nuclear Power Plant Accident and tasks to be improved in future. The primary and secondary organizations in the system above are set up in the prefectures with or neighboring the nuclear facility, and tertiary ones, in two parts of western and eastern Japan. The western organization is in Hiroshima University having its cooperating 7 hospitals, and is responsible for such patients as exposed to high dose external radiation, having serious complication, and difficult to treat in the primary/secondary hospitals. The eastern is in National Institute of Radiological Sciences (NIRS) with 6 cooperating hospitals and responsible for patients with internal radiation exposure difficult to treat, with contaminated body surface with difficulty in decontamination and/or with causable of secondary contamination, and difficult to treat in the secondary hospitals. The tertiary organizations have made efforts for the education and training of medical staff, for network construction among the primary, secondary and other medicare facilities, for establishment of transferring system of patients, and for participation to the international network by global organizations like Response Assistance Network (RANET) in International Atomic Energy Agency (IAEA), and Radiation Emergency Preparedness and Network (REMPAN) in World Health Organization (WHO). At the Fukushima Accident, staffs of the two tertiary hospitals began to conduct medicare on site (Mar. 12-) and learned following tasks to be improved in future: the early definition of medicare and its network system, and Emergency Planning Zone (EPZ); urgent evacuation of residents weak to disaster like elderly

Radiation monitor system for nuclear power plants

International Nuclear Information System (INIS)

Wu Bingzhe; Guo Shusheng

1990-12-01

The system has 8 kinds of radiation monitors and 2 stage microcomputers designed for processing the data from each monitor, storaging the information, printing out and displaying on the colour CRT. The function of the system includes high-value alarm, warm alarm and failure alarm, so called t hree-level alarms . Two functions of the alarms are the threshold alarm and the tendency alarm, so that this system is an intelligency system. This system has high reliability and very wide range when LOCA accident takes place. It is aseismic and immune to industrial interference. The system can meet IEC-761-1 standard and is of nuclear safety 3rd class. Also the following monitors were designed: 133 Xe monitor, 131 I monitor, low-level liquid monitor and high radiation γ area monitor. The system can meet the requirements of nuclear power plants

Oligodendroglioma occurring after radiation therapy for pituitary adenoma

Energy Technology Data Exchange (ETDEWEB)

Chuni Huang; Wenhysang Chiou; Ho, D.M.

1987-12-01

A 38 year old male dentist developed an oligodendroglioma of the left medial temporal lobe and parasellar region 12 years after radiotherapy with 6600 rads for acromegaly. The 30 cases of radiation-induced gliomas reported in the English literature are reviewed and analysed. The criteria for defining radiation-induced tumours of the central nervous system are proposed as follows: the tumour has a long quiescent ''latency period'', a location in the previously irradiated field, a verified histological difference from a primary condition, and does not arise from a primary condition associated with a genetic syndrome such as neurofibromatosis or tuberous sclerosis. The reported case fulfilled these criteria but appears to be the only reported radiation-induced oligodendroglioma.

Feed-back between geriatric syndromes: general system theory in geriatrics.

Science.gov (United States)

Musso, Carlos G; Núñez, Juan F Macías

2006-01-01

Geriatrics has described three entities: confusional syndrome, incontinente and gait disorders, calling them geriatric giants. Aging process also induces changes in renal physiology such as glomerular filtration rate reduction, and alteration in water and electrolytes handling. These ageing renal changes have been named as nephrogeriatric giants. These two groups of giants, geriatric and nephrogeriatric, can predispose and potentiate each other leading old people to fatal outcomes. These phenomenon of feed-back between these geriatric syndromes has its roots in the loss of complexity that the ageing process has. Complexity means that all the body systems work harmoniously. The process of senescence weakens this coordination among systems undermining complexity and making the old person frail.

Space Radiation Intelligence System (SPRINTS), Phase I

Data.gov (United States)

National Aeronautics and Space Administration — NextGen Federal Systems proposes an innovative SPace Radiation INTelligence System (SPRINTS) which provides an interactive and web-delivered capability that...

A radiation monitoring system for nuclear power plants

International Nuclear Information System (INIS)

Iwai, Masaru; Nakamori, S.; Ikeda, H.; Oda, M.

1974-01-01

Safety with respect to radiation is vital factor, particularly in view of the increasing number of nuclear power plants. For this purpose, a radiation monitoring system is provided to perform constant supervision. This article describes the purpose, installation location, specifications and circuitry of a system which is divided into three units: the process monitor, area monitor and off-site monitor. (auth.)

Radiator selection for Space Station Solar Dynamic Power Systems

Science.gov (United States)

Fleming, Mike; Hoehn, Frank

A study was conducted to define the best radiator for heat rejection of the Space Station Solar Dynamic Power System. Included in the study were radiators for both the Organic Rankine Cycle and Closed Brayton Cycle heat engines. A number of potential approaches were considered for the Organic Rankine Cycle and a constructable radiator was chosen. Detailed optimizations of this concept were conducted resulting in a baseline for inclusion into the ORC Preliminary Design. A number of approaches were also considered for the CBC radiator. For this application a deployed pumped liquid radiator was selected which was also refined resulting in a baseline for the CBC preliminary design. This paper reports the results and methodology of these studies and describes the preliminary designs of the Space Station Solar Dynamic Power System radiators for both of the candidate heat engine cycles.

The advancement of stem cells in radiation medicine

International Nuclear Information System (INIS)

Guo Li; Fan Hongxue

2003-01-01

It may result in acute radiation syndrome after body is exposed to ionizing radiation. The one of long-term effects of irradiation injury is leukemia. The bone marrow cells (BMC) transplantation including stem cells is the only effective therapy for acute radiation syndrome patients. Recently, with the advancement of stem cell research that the stem cells have multipotential and can convert each other, it may supply the new stem source for the irradiation injury patients. At the same time with the further research of radioprotective reagents, the hematopoietic stem cells proliferation after irradiation injury is promoted

A systems approach to the management of radiation accidents

International Nuclear Information System (INIS)

Richter, L.L.; Berk, H.W.; Teates, C.D.; Larkham, N.E.; Friesen, E.J.; Edlich, R.F.

1980-01-01

Management of radiation accident patients should have a multidisciplinary approach that includes all health professionals as well as members of public safety agencies. Emergency plans for radiation accidents include detection of the ionizing radiation, patient evacuation, resuscitation, and decontamination. The resuscitated patient should be transported to a radiation control area located outside but adjacent to the emergency department. Ideally this area is accessed through an entrance separate from that used for the main flow of daily emergency department patients. The hospital staff, provided with protective clothing, dosimeters, and preprinted guidelines, continues the resuscitation and definitive care of the patient. This system approach to the management of radiation accidents may be tailored to meet the specific needs of other emergency medical systems

Environmental radiation monitoring system in nuclear power station

International Nuclear Information System (INIS)

Matsuoka, Sadazumi; Tadachi, Katsuo; Endo, Mamoru; Yuya, Hiroshi

1983-01-01

At the time of the construction of nuclear power stations, prior to their start of operation, the state of environmental radiation must be grasped. After the start of the power stations, based on those data, the system of environmental radiation monitoring is established. Along with the construction of Kashiwazaki-Kariwa Nuclear Power Station, The Tokyo Electric Power Co., Inc. jointly with Fujitsu Ltd. has developed a high-reliability, environmental radiation monitoring system, and adopted ''optical data highways'' using optical fiber cables for communication. It consists of a central monitoring station and 11 telemeter observation points, for collecting both radiation and meteorological data. The data sent to the central station through the highways are then outputted on a monitoring panel. They are analyzed with a central processor, and the results are printed out. (Mori, K.)

Automated System of Area Radiation Measurement (ASARM)

International Nuclear Information System (INIS)

Hernandez G, J.

2013-10-01

The realized activities in nuclear facilities involve the determination of the presence of ionizing radiation fields in the workspaces. The instruments designed to detect and to measure these radiation fields provide useful information (specific type of radiation, intensity, etc.) to take the appropriate radiological protection measures, with the purpose of reducing to the minimum the workers exposition and the people in general. The radiological protection program of Reactor TRIGA Mark III contains the instructions and procedures to implement a periodic radiological monitoring, surveillance, rising of contamination levels, type and number of the instruments required for the radiological monitoring of areas and personal. The ana logical monitoring system model Rms II used to detect and measuring exposition speed and neutron radiation fields in several areas of the installation, provides the information in a logarithmic scale measurer of 4 or 5 decades located in a shelf where the previously mentioned measurement channels are centralized. Also inside the reactor monitoring system are two monitors of radioactive material concentration in the air: The particles continuous monitor and the gaseous effluents monitor which present the referred information of the diverse detectors through ana logical readers. These monitors when operating with an ana logical indication does not present the possibility to generate historical files electronically of each monitor previously mentioned neither to generate visual and audible indications of the alarms. This work presents the Automated System of Area Radiation Measurement which potentiated the functionality of the area monitors for gamma and neutron radiation, as well as of the particles continuous monitor and the gaseous effluents of reactor TRIGA Mark III, when being developed a computer system that captures in real time the information of all the monitors, generating this way an electronic binnacle, a visual and audible alarm

Progressive Systemic sclerosis, manifested like malabsorption syndrome. Case report

International Nuclear Information System (INIS)

Ortiz Piza, Gabriel Jaime; Gonzalez Vasquez, Carlos Mario

2005-01-01

We report the case of a 32 year old woman whose first manifestation of systemic sclerosis was malabsorption syndrome. The small bowel series was the clue to the diagnosis, confirmed by laboratory tests and progression of the disease

Complex systems of biological interest stability under ionising radiations

International Nuclear Information System (INIS)

Maclot, Sylvain

2014-01-01

This PhD work presents the study of stability of molecular systems of biological interest in the gas phase after interaction with ionising radiations. The use of ionising radiation can probe the physical chemistry of complex systems at the molecular scale and thus consider their intrinsic properties. Beyond the fundamental aspect, this work is part of the overall understanding of radiation effects on living organisms and in particular the use of ionizing radiation in radiotherapy. Specifically, this study focused on the use of low-energy multiply charged ions (tens of keV) provided by the GANIL (Caen), which includes most of the experiments presented. In addition, experiments using VUV photons were also conducted at synchrotron ELETTRA (Trieste, Italy). The bio-molecular systems studied are amino acids and nucleic acid constituents. Using an experimental crossed beams device allows interaction between biomolecules and ionising radiation leads mainly to the ionization and fragmentation of the system. The study of its relaxation dynamics is by time-of-flight mass spectrometry coupled to a coincidences measurements method. It is shown that an approach combining experiment and theory allows a detailed study of the fragmentation dynamics of complex systems. The results indicate that fragmentation is generally governed by the Coulomb repulsion but the intramolecular rearrangements involve specific relaxation mechanisms. (author) [fr

Development Of Data Acquisition Software For Centralized Radiation Monitoring System

International Nuclear Information System (INIS)

Nolida Yussup; Maslina Mohd Ibrahim; Mohd Fauzi Haris; Syirrazie Che Soh; Harzawardi Hasim; Azraf Azman; Mohd Ashhar Khalid

2014-01-01

Nowadays, with the growth of technology, many devices and equipment's can be connected to the network and internet to enable online data acquisition. Centralized radiation monitoring system utilizes a Local Area Network (LAN) as a communication media for data acquisition of the area radiation levels from radiation detectors in Malaysian Nuclear Agency (Nuclear Malaysia). The development of the system involves device configuration, wiring, network and hardware installation, software and web development. This paper describes the software development on the system server that is responsible to acquire and record the area radiation readings from the detectors. Then the recorded readings are called in a web programming to be displayed on a web site. The readings with the time stamp are stored in the system database for query. Besides acquiring the area radiation levels in Nuclear Malaysia centrally, additional features such as data conversion from mR to μSv and line chart display are developed in the software for effective radiation level trend observation and studies. (author)

Limbic system, the main focus of dementia syndrome; A study with MRI and PET

Energy Technology Data Exchange (ETDEWEB)

Matsuzawa, Taiju [Morinosato Hospital, Atsugi, Kanagawa (Japan)

1990-12-01

Alzheimer disease and multi-infarct dementia are two entirely different diseases producing almost the same abnormalities as dementia syndrome. The statistical studies with MRI to locate the focus of dementia syndrome in the neocortex was an absolute failure. With MRI there is drastic atrophy and destruction of the amygdala and hippocampus suggesting the limbic system as the focus of dementia syndrome. Destruction of the limbic system in particular amygdala and hippocampus produced the functional obstruction brought about by the marked reduction in the glucose utilization with PET in the bilateral temporal, parietal and occipital association cortices. Although this type constitutes only about 1/5 of all dementia patients. It is considered the fundamental type of dementia syndrome. Aside from this, there is a type wherein simultaneous and symmetrical reductions in glucose utilization of the frontal association cortex and the motor association cortex in the anterior part of the neocortex. This is referred to as type II. It constitutes about 4/5 of all dementia patients which is far more than type I. Based on these results, it is thought that limbic system is the main focus of dementia syndrome. (author).

Analysis of food radiation monitoring system in Belarus

International Nuclear Information System (INIS)

1992-01-01

Food radiation monitoring system in Belarus due to the Chernobyl accident is analysed. Structure of radiation monitoring network, instrumentation and modern developments. Information on permissible concentration levels in foodstuffs and water is presented and calculations of radionuclide intake for man are performed. Proposals on the creation of social centres of food radiation monitoring for Belarussian population are considered. 4 tabs

Online radiation dose measurement system for ATLAS experiment

International Nuclear Information System (INIS)

Mandic, I.; Cindro, V.; Dolenc, I.; Gorisek, A.; Kramberger, G.; Mikuz, M.; Bronner, J.; Hartet, J.; Franz, S.

2009-01-01

In experiments at Large Hadron Collider, detectors and electronics will be exposed to high fluxes of photons, charged particles and neutrons. Damage caused by the radiation will influence performance of detectors. It will therefore be important to continuously monitor the radiation dose in order to follow the level of degradation of detectors and electronics and to correctly predict future radiation damage. A system for online radiation monitoring using semiconductor radiation sensors at large number of locations has been installed in the ATLAS experiment. Ionizing dose in SiO 2 will be measured with RadFETs, displacement damage in silicon in units of 1-MeV(Si) equivalent neutron fluence with p-i-n diodes. At 14 monitoring locations where highest radiation levels are expected the fluence of thermal neutrons will be measured from current gain degradation in dedicated bipolar transistors. The design of the system and tests of its performance in mixed radiation field is described in this paper. First results from this test campaign confirm that doses can be measured with sufficient sensitivity (mGy for total ionizing dose measurements, 10 9 n/cm 2 for NIEL (non-ionizing energy loss) measurements, 10 12 n/cm 2 for thermal neutrons) and accuracy (about 20%) for usage in the ATLAS detector

Central nervous system involvement in primary Sjogren`s syndrome manifesting as multiple sclerosis.

Science.gov (United States)

Liu, Jing-Yao; Zhao, Teng; Zhou, Chun-Kui

2014-04-01

Central nervous system symptoms in patients with primary Sjogren`s syndrome are rare. They can present as extraglandular manifestations and require a differential diagnosis from multiple sclerosis. Due to a variety of presentations, Sjogren`s syndrome with neurologic involvement may be difficult to diagnose. Here, we report a case of a 75-year-old woman who was first diagnosed with multiple sclerosis in 2010, but who was subsequently diagnosed with primary Sjogren`s syndrome 2 years later after showing signs of atypical neurologic manifestations. Therefore, primary Sjogren`s syndrome should be suspected in patients who present with atypical clinical and radiologic neurologic manifestations.

Radioprotection against radiation induced bone marrow syndrome by a semi-synthetic derivative of chlorophyll

International Nuclear Information System (INIS)

Suryavanshi, Shweta; Sharma, Deepak; Checker, Rahul; Santosh Kumar, S.; Sainis, Krishna B.

2014-01-01

A plethora of biological properties have been attributed to chlorophyllin (CHL), the water soluble derivative of the green plant pigment chlorophyll. Several studies are available describing its ability to modify genotoxic effects. It has been shown that administration CHL to human lymphopenic individuals led to the recovery and restoration of the immune system and also inhibited aflatoxin B1-DNA binding in individuals residing in high risk exposure to this liver carcinogen. The present study is aimed at establishing radioprotective efficacy of CHL against ionizing radiation induced hematopoietic syndrome. CHL offered complete protection against whole body irradiation (WBI, 7 Gy) induced mortality in mice. This observation was supported by increase in the number of macroscopic endogenous colonies enumerated on the surface of the spleens taken from CHL+WBI group as compared to WBI group. Radioprotection by CHL was found to be mediated by increasing the frequency of hematopoietic stem cells (HSCs) as evaluated by side population assay. Administration of CHL induced G1 arrest in bone marrow cells, increased number of granulocytes and neutrophils in the peripheral blood. At the molecular level, activation of ERK was observed in bone marrow cells obtained from CHL administered mice. In conclusion, CHL mediated radioprotection was attributed to increased stem cell numbers, G1 arrest in bone marrow cells, increased neutrophil numbers and ERK activation. (author)

Report on the Radiation Effects Testing of the Infrared and Optical Transition Radiation Camera Systems

Energy Technology Data Exchange (ETDEWEB)

Holloway, Michael Andrew [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2016-04-20

Presented in this report are the results tests performed at Argonne National Lab in collaboration with Los Alamos National Lab to assess the reliability of the critical ⁹⁹Mo production facility beam monitoring diagnostics. The main components of the beam monitoring systems are two cameras that will be exposed to radiation during accelerator operation. The purpose of this test is to assess the reliability of the cameras and related optical components when exposed to operational radiation levels. Both X-ray and neutron radiation could potentially damage camera electronics as well as the optical components such as lenses and windows. This report covers results of the testing of component reliability when exposed to X-ray radiation. With the information from this study we provide recommendations for implementing protective measures for the camera systems in order to minimize the occurrence of radiation-induced failure within a ten month production run cycle.

Effect of gamma radiation on graphite – PTFE dry lubrication system

International Nuclear Information System (INIS)

Singh, Sachin; Tyagi, Mukti; Seshadri, Geetha; Tyagi, Ajay Kumar; Varshney, Lalit

2017-01-01

An effect of gamma radiation on lubrication behavior of graphite -PTFE dry lubrication system has been studied using (TR-TW-30L) tribometer with thrust washer attachment in plane contact. Different compositions of graphite and PTFE were prepared and irradiated by gamma rays. Gamma radiation exposure significantly improves the tribological properties indicated by decrease in coefficient of friction and wear properties of graphite -PTFE dry lubrication system. SEM and XRD analysis confirm the physico-chemical modification of graphite-PTFE on gamma radiation exposure leading to a novel dry lubrication system with good slip and anti friction properties. - Highlights: • Novel dry lubrication system of graphite -PTFE using gamma radiation. • Gamma radiation processing. • Reduction in coefficient of friction, frictional torque and wear loss of developed dry lubrication system.

The characteristics of autonomic nervous system disorders in burning mouth syndrome and Parkinson disease.

Science.gov (United States)

Koszewicz, Magdalena; Mendak, Magdalena; Konopka, Tomasz; Koziorowska-Gawron, Ewa; Budrewicz, Sławomir

2012-01-01

To conduct a clinical electrophysiologic evaluation of autonomic nervous system functions in patients with burning mouth syndrome and Parkinson disease and estimate the type and intensity of the autonomic dysfunction. The study involved 83 subjects-33 with burning mouth syndrome, 20 with Parkinson disease, and 30 controls. The BMS group included 27 women and 6 men (median age, 60.0 years), and the Parkinson disease group included 15 women and 5 men (median age, 66.5 years). In the control group, there were 20 women and 10 men (median age, 59.0 years). All patients were subjected to autonomic nervous system testing. In addition to the Low autonomic disorder questionnaire, heart rate variability (HRV), deep breathing (exhalation/inspiration [E/I] ratio), and sympathetic skin response (SSR) tests were performed in all cases. Parametric and nonparametric tests (ANOVA, Kruskal-Wallis, and Scheffe tests) were used in the statistical analysis. The mean values for HRV and E/I ratios were significantly lower in the burning mouth syndrome and Parkinson disease groups. Significant prolongation of SSR latency in the foot was revealed in both burning mouth syndrome and Parkinson disease patients, and lowering of the SSR amplitude occurred in only the Parkinson disease group. The autonomic questionnaire score was significantly higher in burning mouth syndrome and Parkinson disease patients than in the control subjects, with the Parkinson disease group having the highest scores. In patients with burning mouth syndrome, a significant impairment of both the sympathetic and parasympathetic nervous systems was found but sympathetic/parasympathetic balance was preserved. The incidence and intensity of autonomic nervous system dysfunction was similar in patients with burning mouth syndrome and Parkinson disease, which may suggest some similarity in their pathogeneses.

Portable radiation detector and mapping system

International Nuclear Information System (INIS)

Hofstetter, K.J.; Hayes, D.W.; Eakle, R.F.

1995-01-01

A portable radiation detector and mapping system (RADMAPS) has been developed to detect, locate and plot nuclear radiation intensities on commercially available digital maps and other images. The field unit records gamma-ray spectra or neutron signals together with positions from a Global Positioning System (GPS) on flash memory cards. The recorded information is then transferred to a lap-top computer for spectral data analyses and then georegistered graphically on maps, photographs, etc. RADMAPS integrates several existing technologies to produce a preprogrammable field unit uniquely suited for each survey, as required. The system presently records spectra from a Nal(Tl) gamma-ray detector or an enriched Li-6 doped glass neutron scintillator. Standard Geographic Information System software installed in a lap-top, complete with CD-ROM supporting digitally imaged maps, permits the characterization of nuclear material in the field when the presence of such material is not otherwise documented. This paper gives the results of a typical site survey of the Savannah River Site (SRS) using RADMAPS

Central Nervous System (CNS Disease Triggering Takotsubo Syndrome

Directory of Open Access Journals (Sweden)

Josef Finsterer

2016-01-01

Full Text Available Takotsubo syndrome (TTS is usually triggered by psychological or physical stress. One of the many physical sources of stress are central nervous system (CNS disorders. CNS disorders most frequently triggering TTS include subarachnoid bleeding, epilepsy, ischemic stroke, migraine, and intracerebral bleeding. More rare CNS-triggers of TTS include posterior reversible encephalopathy syndrome (PRES, amyotrophic lateral sclerosis, encephalitis, or traumatic brain or spinal cord injury. TTS triggered by any of the CNS disorders needs to be recognized since adequate treatment of TTS may improve the general outcome from the CNS disorder as well. Neurologists need to be aware of TTS as a complication of specific CNS disorders but TTS may be triggered also by CNS disorders so far not recognised as causes of TTS.

The Advanced Light Source (ALS) Radiation Safety System

International Nuclear Information System (INIS)

Ritchie, A.L.; Oldfather, D.E.; Lindner, A.F.

1993-08-01

The Advanced Light Source (ALS) at the Lawrence Berkeley Laboratory (LBL) is a 1.5 Gev synchrotron light source facility consisting of a 120 kev electron gun, 50 Mev linear accelerator, 1.5 Gev booster synchrotron, 200 meter circumference electron storage ring, and many photon beamline transport systems for research. Figure 1. ALS floor plan. Pairs of neutron and gamma radiation monitors are shown as dots numbered from 1 to 12. The Radiation Safety System for the ALS has been designed and built with a primary goal of providing protection against inadvertent personnel exposure to gamma and neutron radiation and, secondarily, to enhance the electrical safety of select magnet power supplies

Computerized radiation control system in the Chernobyl 30-km zone

International Nuclear Information System (INIS)

Vasil'chenko, D.L.; Pis'mak, A.D.; Livertovskij, G.P.; Chikhladze, V.S.

1992-01-01

Computerized radiation control system is intended for monitoring radiation in the zone of radiation-hazardous objects for providing nuclear power station services with current information on radiactive situation in the zone of observation and the doses of radiation taken by the personnel. Described are tasks and functions of the system, as well as its structure. It is noted that unique conditions of the Chernobyl' 30-km zone open up opportunities for experiments and testing new models of equipment. 2 figs

Radiation systems for luggage and parcel checks

International Nuclear Information System (INIS)

Honomichl, V.

1989-01-01

The current radioscopic systems of luggage check in air traffic are based on the principle of intensifying the brightness of half-tone images on the fluorescent screen of an image intensifier, or use of very sensitive pick-up tubes with digital image processing. Computers are used for signal processing and the image is produced on a display unit. Sources of continuous or pulse X-ray radiation are used. The signals from the detector are amplified, converted and stored in a buffer and then displayed. The scanning systems use a narrow beam or, to improve rapidity and sensitivity of scanning, a sector beam of radiation. Equipment is described from Heinemann (FRG) featuring a band of 576 or 768 detectors and microprocessor controlled semiconductor tv cameras. Characteristics are also presented of equipment from Aeradio Ltd (U.K.) and Philips (FRG) companies. Attention is devoted to equipment from American Science and Engineering (U.S.) showing high quality imaging even at low radiation doses. Briefly described are portable check systems for inspection of small luggage and parcels. Characteristics are presented of systems for checking vehicles and containers in naval, air, rail and road transport. The principles and performance are described of the systems. (J.B.). 4 figs

Redefining syndromic surveillance

Directory of Open Access Journals (Sweden)

Rebecca Katz

2011-12-01

Full Text Available With growing concerns about international spread of disease and expanding use of early disease detection surveillance methods, the field of syndromic surveillance has received increased attention over the last decade. The purpose of this article is to clarify the various meanings that have been assigned to the term syndromic surveillance and to propose a refined categorization of the characteristics of these systems. Existing literature and conference proceedings were examined on syndromic surveillance from 1998 to 2010, focusing on low- and middle-income settings. Based on the 36 unique definitions of syndromic surveillance found in the literature, five commonly accepted principles of syndromic surveillance systems were identified, as well as two fundamental categories: specific and non-specific disease detection. Ultimately, the proposed categorization of syndromic surveillance distinguishes between systems that focus on detecting defined syndromes or outcomes of interest and those that aim to uncover non-specific trends that suggest an outbreak may be occurring. By providing an accurate and comprehensive picture of this field’s capabilities, and differentiating among system types, a unified understanding of the syndromic surveillance field can be developed, encouraging the adoption, investment in, and implementation of these systems in settings that need bolstered surveillance capacity, particularly low- and middle-income countries.

Radioresistant DNA synthesis in fibroblasts of a patient with Down's syndrome

International Nuclear Information System (INIS)

Barenfel'd, L.S.; Bil'din, V.N.; Pleskach, N.M.; Prokof'eva, V.V.

1985-01-01

Ionizing radiation effect on DNA replication on fibroblasts of a healthy donor and a patient with Down's syndrome either by direct 3 H-thymidine inclusion into DNA, or by analysis of the sizes of daughter DNA moleculs at the state of stable distribution in acid saccharose, gradients was studied. Gamma-radiation doses (5-10 Gy) suppressing DNA synthesis in normal fibroblasts practically had no effect on DNA synthesisin fibroblasts of a patient with Down's syndrome. Radioresistant DNA synthesis in Down's syndrome is conditioned by a far less supression of replicon initiation as compared with the one in normal cells. So, it is stated that in Down's disease there is no delay in DNA synthesis by ionizing radiation that enables the normal cells to repair DNA damages before replication renewal

Hybrid Active-Passive Radiation Shielding System

Data.gov (United States)

National Aeronautics and Space Administration — A radiation shielding system is proposed that integrates active magnetic fields with passive shielding materials. The objective is to increase the shielding...

Glutathione system in Wolfram syndrome 1‑deficient mice.

Science.gov (United States)

Porosk, Rando; Kilk, Kalle; Mahlapuu, Riina; Terasmaa, Anton; Soomets, Ursel

2017-11-01

Wolfram syndrome 1 (WS) is a rare neurodegenerative disease that is caused by mutations in the Wolfram syndrome 1 (WFS1) gene, which encodes the endoplasmic reticulum (ER) glycoprotein wolframin. The pathophysiology of WS is ER stress, which is generally considered to induce oxidative stress. As WS has a well‑defined monogenetic origin and a model for chronic ER stress, the present study aimed to characterize how glutathione (GSH), a major intracellular antioxidant, was related to the disease and its progression. The concentration of GSH and the activities of reduction/oxidation system enzymes GSH peroxidase and GSH reductase were measured in Wfs1‑deficient mice. The GSH content was lower in most of the studied tissues, and the activities of antioxidative enzymes varied between the heart, kidneys and liver tissues. The results indicated that GSH may be needed for ER stress control; however, chronic ER stress from the genetic syndrome eventually depletes the cellular GSH pool and leads to increased oxidative stress.

ISS--an electronic syndromic surveillance system for infectious disease in rural China.

Directory of Open Access Journals (Sweden)

Weirong Yan

Full Text Available BACKGROUND: Syndromic surveillance system has great advantages in promoting the early detection of epidemics and reducing the necessities of disease confirmation, and it is especially effective for surveillance in resource poor settings. However, most current syndromic surveillance systems are established in developed countries, and there are very few reports on the development of an electronic syndromic surveillance system in resource-constrained settings. OBJECTIVE: This study describes the design and pilot implementation of an electronic surveillance system (ISS for the early detection of infectious disease epidemics in rural China, complementing the conventional case report surveillance system. METHODS: ISS was developed based on an existing platform 'Crisis Information Sharing Platform' (CRISP, combining with modern communication and GIS technology. ISS has four interconnected functions: 1 work group and communication group; 2 data source and collection; 3 data visualization; and 4 outbreak detection and alerting. RESULTS: As of Jan. 31(st 2012, ISS has been installed and pilot tested for six months in four counties in rural China. 95 health facilities, 14 pharmacies and 24 primary schools participated in the pilot study, entering respectively 74,256, 79,701, and 2330 daily records into the central database. More than 90% of surveillance units at the study sites are able to send daily information into the system. In the paper, we also presented the pilot data from health facilities in the two counties, which showed the ISS system had the potential to identify the change of disease patterns at the community level. CONCLUSIONS: The ISS platform may facilitate the early detection of infectious disease epidemic as it provides near real-time syndromic data collection, interactive visualization, and automated aberration detection. However, several constraints and challenges were encountered during the pilot implementation of ISS in rural China.

Development of multi copter based autonomous unmanned aerial radiation monitoring system for the remote impact assessment of radiation emergencies

International Nuclear Information System (INIS)

Jose, Jis Romal; Gupta, Ashutosh; Bahadur, Shuchita; Chaudhury, Probal; Pradeepkumar, K.S.

2016-01-01

During any radiation emergency, the level and extent of radioactive contamination need to be monitored for the timely and effective implementation of countermeasures to reduce the radiation exposure to public. In such a scenario, radiation surveillance can be carried out using either ground based mobile monitoring techniques or aerial radiation monitoring. Aerial radiation monitoring is quick and capable of scanning the areas which are not easily accessible by the ground based mobile monitoring. Compact unmanned aerial vehicle based radiation surveillance system is ideal in above mentioned radiation emergency scenarios as it can be rapidly deployed in the affected area and radiation exposure to the monitoring personal can be totally avoided. This paper describes development of multi copter based autonomous unmanned aerial radiation monitoring system for the remote impact assessment of radiation emergencies

Thermal analysis of an HVAC system with TRV controlled hydronic radiator

DEFF Research Database (Denmark)

Tahersima, Fatemeh; Stoustrup, Jakob; Rasmussen, Henrik

2010-01-01

A model for an HVAC system is derived in this paper. The HVAC system consists of a room and a hydronic radiator with temperature regulating valve (TRV) which has a step motor to adjust the valve opening. The heating system and the room are simulated as a unit entity for thermal analysis and contr......A model for an HVAC system is derived in this paper. The HVAC system consists of a room and a hydronic radiator with temperature regulating valve (TRV) which has a step motor to adjust the valve opening. The heating system and the room are simulated as a unit entity for thermal analysis...... and controller design. A discrete-element model with interconnected small scaled elements is proposed for the radiator. This models the radiator more precisely than that of a lumped model in terms of transfer delay and radiator gain. This precise modeling gives us an intuition into a regular unwanted phenomenon...... which occurs in low demand situations. When flow is very low in radiator and the supply water temperature and the pressure drop across the valve is constant, oscillation in room temperature occurs. One reason could be the large gain of radiator in low demand conditions compared to the high demand...

Radiation therapy for Kaposi's sarcoma associated with acquired immunodeficiency syndrome. Tokyo Metropolitan Komagome Hospital experience

International Nuclear Information System (INIS)

Ebara, Takeshi; Karasawa, Katsuyuki; Maebayashi, Katsuya; Kurosaki, Hiromasa; Ishikawa, Hitoshi; Kaizu, Toshihide; Tanaka, Yoshiaki; Akagi, Kumiko; Masuda, Gota

2000-01-01

Kaposi's sarcoma is frequently found in association with acquired immunodeficiency syndrome (AIDS). We report on radiotherapy for patients with AIDS-related Kaposi's sarcoma at Tokyo Metropolitan Komagome Hospital. Between April 1991 and May 1997, radiotherapy was given to 11 lesions in eight men with AIDS-related Kaposi's sarcoma to relieve their symptoms. The lesions involved the head and neck region, the legs, and the gastrointestinal tract. Radiotherapy was carried out with 4-MV photon through parallel opposed field or high energy electrons. Total doses ranged from 20 to 38 Gy, with a median of 30 Gy, delivered in 2- to 3-Gy fractions. Four patients were given other treatments prior to the radiotherapy. Acute reaction was evaluated according to the modified acute radiation morbidity scoring criteria of the Radiation Therapy Oncology Group (RTOG). Radiotherapy had relieved the symptoms in all patients at completion of this therapy. Lesions that involved the hard palate and vocal cords had completely disappeared. The lesions that received radiotherapy were controlled without symptoms until the patients died. Patients who had the head and neck region treated exhibited severe acute mucosal reaction (at a dose of 30 Gy, there was grade 2 morbidity by modified RTOG criteria, in two patients, and grade 3 in three patients) although the radiation therapy was completed for these patients. Radiotherapy promises a favorable outcome for symptom relief in AIDS-related Kaposi's sarcoma. (author)

Radiation induced effects in the developing central nervous system

International Nuclear Information System (INIS)

Gisone, P.; Dubner, D.; Michelin, S.C.; Perez, M.R. Del

1997-01-01

The embryo and the human foetus are particularly sensitive to ionizing radiation and this sensitivity presents various qualitative and quantitative functional changes during intra-uterine development. Apart from radiation induced carcinogenesis, the most serious consequence of prenatal exposure in human beings is severe mental retardation. The principal data on radiation effects on human beings in the development of the central nervous system come form epidemiological studies carried out in individuals exposed in utero during the atomic explosion at Hiroshima and Nagasaki. These observations demonstrate the existence of a time of maximum radiosensitivity between the weeks 8 and 15 of the gestational period, a period in which the proliferation and neuronal migration takes place. Determination of the characteristics of dose-response relationship and the possible existence of a threshold dose of radiation effects on the development of the central nervous system is relevant to radiation protection against low dose radiation and the establishment of dose limits for occupational exposure and the public. Studies were conducted on the generation of nitrous-oxide and its relation with the production of active species of oxygen in brains of exposed rats in utero exposed to doses of up to 1 Gy during their maximum radiosensitivity. The possible role of the mechanism of radiation induced damage in the development of the central nervous system is discussed

The wireless sensor network monitoring system for regional environmental nuclear radiation

International Nuclear Information System (INIS)

Liu Chong; Liu Dao; Wang Yaojun; Xie Yuxi; Song Lingling

2012-01-01

The wireless sensor network (WSN) technology has been utilized to design a new regional environmental radiation monitoring system based on the wireless sensor networks to meet the special requirements of monitoring the nuclear radiation in certain regions, and realize the wireless transmission of measurement data, information processing and integrated measurement of the nuclear radiation and the corresponding environmental parameters in real time. The system can be applied to the wireless monitoring of nuclear radiation dose in the nuclear radiation environment. The measured data and the distribution of radiation dose can be vividly displayed on the graphical interface in the host computer. The system has functioned with the wireless transmission and control, the data storage, the historical data inquiry, the node remote control. The experimental results show that the system has the advantages of low power consumption, stable performance, network flexibility, range of measurement and so on. (authors)

Masquerade Syndrome of Multicentre Primary Central Nervous System Lymphoma

Directory of Open Access Journals (Sweden)

Silvana Guerriero

2011-01-01

Full Text Available Purpose. In Italy we say that the most unlucky things can happen to physicians when they get sick, despite the attention of colleagues. To confirm this rumor, we report the sad story of a surgeon with bilateral vitreitis and glaucoma unresponsive to traditional therapies. Methods/Design. Case report. Results. After one year of steroidal and immunosuppressive therapy, a vitrectomy, and a trabeculectomy for unresponsive bilateral vitreitis and glaucoma, MRI showed a multicentre primary central nervous system lymphoma, which was the underlying cause of the masquerade syndrome. Conclusions. All ophthalmologists and clinicians must be aware of masquerade syndromes, in order to avoid delays in diagnosis.

Effects of ionizing radiation on the immune system

International Nuclear Information System (INIS)

Dubois, J.B.

1986-01-01

After reviewing the different lymphoid organs and the essential phases of the immune response, we studied the morphological and functional effects of ionizing radiation on the immunological system. Histologic changes in the lymph nodes, spleen, thymus, and different lymphocyte subpopulations were studied in relation with the radiation dose and irradiated volume (whole body irradiation, localized irradiation). Functional changes in the immune system induced by ionizing radiation were also investigated by a study of humoral-mediated immunity (antibody formation) and cell-mediated immunity (behavior of macrophages, B-cells, T suppressor cells, T helper cells, T effector cells, and natural killer cells). A study into the mechanisms of action of ionizing radiation and the immune processes it interferes with suggests several likely hypotheses (direct action on the immune cells, on their precursors, on seric mediators or on cell mediators). The effects on cancer patients' immune reactions of low radiation doses delivered to the various lymphoid organs are discussed, as well as the relationships between the host and the evolution of the tumor [fr

Project Management of a personnel radiation records computer system

International Nuclear Information System (INIS)

Labenski, T.

1984-01-01

Project Management techniques have been used to develop a data base management information system to provide storage and retrieval of personnel radiation and Health Physics records. The system is currently being developed on a Hewlett Packard 1000 Series E Computer with provisions to include plant radiation survey information, radiation work permit information, inventory management for Health Physics supplies and instrumentation, and control of personnel access to radiological controlled areas. The methodologies used to manage the overall project are presented along with selection and management of software vendors

Online radiation dose measurement system for ATLAS experiment

Energy Technology Data Exchange (ETDEWEB)

Mandic, I.; Cindro, V.; Dolenc, I.; Gorisek, A.; Kramberger, G. [Jozef Stefan Institute, Jamova 39, Ljubljana (Slovenia); Mikuz, M. [Jozef Stefan Institute, Jamova 39, Ljubljana (Slovenia); Faculty of Mathematics and Physics, University of Ljubljana (Slovenia); Bronner, J.; Hartet, J. [Physikalisches Institut, Universitat Freiburg, Hermann-Herder-Str. 3, Freiburg (Germany); Franz, S. [CERN, Geneva (Switzerland)

2009-07-01

In experiments at Large Hadron Collider, detectors and electronics will be exposed to high fluxes of photons, charged particles and neutrons. Damage caused by the radiation will influence performance of detectors. It will therefore be important to continuously monitor the radiation dose in order to follow the level of degradation of detectors and electronics and to correctly predict future radiation damage. A system for online radiation monitoring using semiconductor radiation sensors at large number of locations has been installed in the ATLAS experiment. Ionizing dose in SiO{sub 2} will be measured with RadFETs, displacement damage in silicon in units of 1-MeV(Si) equivalent neutron fluence with p-i-n diodes. At 14 monitoring locations where highest radiation levels are expected the fluence of thermal neutrons will be measured from current gain degradation in dedicated bipolar transistors. The design of the system and tests of its performance in mixed radiation field is described in this paper. First results from this test campaign confirm that doses can be measured with sufficient sensitivity (mGy for total ionizing dose measurements, 10{sup 9} n/cm{sup 2} for NIEL (non-ionizing energy loss) measurements, 10{sup 12} n/cm{sup 2} for thermal neutrons) and accuracy (about 20%) for usage in the ATLAS detector

Radiation myelopathy in over-irradiated patients: MR imaging findings

International Nuclear Information System (INIS)

Alfonso, E.R.; Gregorio, M.A. de; Mateo, P.; Esco, R.; Bascon, N.; Morales, F.; Bellosta, R.; Lopez, P.; Gimeno, M.; Roca, M.; Villavieja, J.L.

1997-01-01

The objective of this work is to report the MRI findings in patients with radiation myelopathy due to accidental local over-irradiation syndrome. Eight patients (seven males and one female) were suffering from over-irradiation syndrome as a result of treatments from a malfunctioning linear electron accelerator. The mean accidental estimated dose was 136 Gy delivered to the ''open-neck'' (seven cases) and to the thoracic wall (one case), during a mean of 5.4 sessions (range 1-9 sessions). Paresthesia and weakness in the upper extremities were the earliest symptoms (87.5 %), with evolution to paralysis in all patients. No patient is alive (mean survival time 64 days). In all cases MRI was negative for neurologic lesions in the acute phase (< 90 days from irradiation; Radiation Therapy Oncology Group scoring system). Late signs of radiation myelitis manifested as high-intensity signals on T2-weighted images in three patients, and as Gd-DTPA enhancement of T1-weighted images in one case. Autopsies performed on four patients who died in acute phase showed morphologic alterations in white matter: edema in 75 %, and necrosis and glial reaction as well as obliterative vasculitis in all cases. In cases of over-irradiation, MRI may be normal in acute phase even if the patients have severe neurologic deficit, as positive MRI findings appear only in delayed radiation myelitis. (orig.). With 3 figs., 2 tabs

Radiation myelopathy in over-irradiated patients: MR imaging findings

Energy Technology Data Exchange (ETDEWEB)

Alfonso, E.R. [Radiology Service, Hospital Clinico Universitario, Zaragoza (Spain); Gregorio, M.A. de [Radiology Service, Hospital Clinico Universitario, Zaragoza (Spain); Mateo, P. [Radiation Oncology Service, Hospital Clinico Universitario, Zaragoza (Spain); Esco, R. [Radiation Oncology Service, Hospital Clinico Universitario, Zaragoza (Spain); Bascon, N. [Radiation Oncology Service, Hospital Clinico Universitario, Zaragoza (Spain); Morales, F. [Neurology Service, Hospital Clinico Universitario, Zaragoza (Spain); Bellosta, R. [Radiation Oncology Service, Hospital Clinico Universitario, Zaragoza (Spain); Lopez, P. [Radiation Oncology Service, Hospital Clinico Universitario, Zaragoza (Spain); Gimeno, M. [Hospital Miguel Servet, Zaragoza (Spain); Roca, M. [Radiology Service, Hospital Miguel Servet, E-50 009 Zaragoza (Spain); Villavieja, J.L. [Radiology Service, Hospital Clinico Universitario, Zaragoza (Spain)

1997-04-01

The objective of this work is to report the MRI findings in patients with radiation myelopathy due to accidental local over-irradiation syndrome. Eight patients (seven males and one female) were suffering from over-irradiation syndrome as a result of treatments from a malfunctioning linear electron accelerator. The mean accidental estimated dose was 136 Gy delivered to the ``open-neck`` (seven cases) and to the thoracic wall (one case), during a mean of 5.4 sessions (range 1-9 sessions). Paresthesia and weakness in the upper extremities were the earliest symptoms (87.5 %), with evolution to paralysis in all patients. No patient is alive (mean survival time 64 days). In all cases MRI was negative for neurologic lesions in the acute phase (< 90 days from irradiation; Radiation Therapy Oncology Group scoring system). Late signs of radiation myelitis manifested as high-intensity signals on T2-weighted images in three patients, and as Gd-DTPA enhancement of T1-weighted images in one case. Autopsies performed on four patients who died in acute phase showed morphologic alterations in white matter: edema in 75 %, and necrosis and glial reaction as well as obliterative vasculitis in all cases. In cases of over-irradiation, MRI may be normal in acute phase even if the patients have severe neurologic deficit, as positive MRI findings appear only in delayed radiation myelitis. (orig.). With 3 figs., 2 tabs.

Microprocessor based mobile radiation survey system

International Nuclear Information System (INIS)

Gilbert, R.W.; McCormack, W.D.

1983-12-01

A microprocessor-based system has been designed and constructed to enhance the performance of routine radiation surveys on roads within the Hanford site. This device continually monitors system performance and output from four sodium iodide detectors mounted on the rear bumper of a 4-wheel drive truck. The gamma radiation count rate in counts-per-second is monitored, and a running average computed, with the results compared to predefined limits. If an abnormal instantaneous or average count rate is detected, an alarm is sounded with responsible data displayed on a liquid crystal panel in the cab of the vehicle. The system also has the capability to evaluate detector output using multiple time constants and to perform more complex tests and comparison of the data. Data can be archived for later analysis on conventional chart recorders or stored in digital form on magnetic tape or other digital storage media. 4 figures

Health management of radiation workers

International Nuclear Information System (INIS)

Kunugita, Naoki; Igari, Kazuyuki

2013-01-01

People in Japan have expressed great anxiety about possible radiation and radioactivity after the accident at the Fukushima Daiichi Nuclear Power Plant of Tokyo Electric Power Company's (TEPCO), due to the great earthquake and tsunami in eastern Japan on 11 March 2011. A large number of workers were engaged in response and recovery operations, and they were possibly exposed to high doses of radiation as compared to the general population. In the accident at the Chernobyl Nuclear Power Plant in 1986, high doses of radiation to 134 plant staff and emergency personnel resulted in acute radiation syndrome (ARS), which proved fatal for 28 of them. In the Fukushima accident, six workers were exposed to more than 250 mSv of radiation during the initial response phase, but no one showed ARS. It is necessary to continue registration of radiation doses for all workers who were exposed to radiation to facilitate suitable healthcare management in the future. In addition to radiation exposure, a group of workers were also exposed to other health hazards. Frequent occurrence of heat disorders has been a concern for the workers wearing protective clothing with poor ventilation. A comprehensive program to prevent heat illness was implemented by TEPCO under the guidance of the Ministry of Health, Labour, and Welfare. It is important to provide effective systems not only for prevention of radiation exposure but also for general management of other health risks including heat disorders and infection. (author)

Acute radiation syndrones and their management

Energy Technology Data Exchange (ETDEWEB)

Cronkite, E.P.

1988-01-01

Radiation syndromes produced by large doses of ionizing radiation are divided into three general groups depending on dose of radiation and time after exposure. The CNS syndrome requires many thousands of rad, appears in minutes to hours, and kills within hours to days. The GIS appears after doses of a few hundred to 2000 rad. It is characterized by nausea, vomiting, diarrhea, and disturbances of water and electrolyte metabolism. It has a high mortality in the first week after exposure. Survivors will then experience the HS as a result of marrow aplasia. Depending on dose, survival is possible with antibiotic and transfusion therapy. The relationship of granulocyte depression to mortality in dogs and human beings is illustrated. The role of depth dose pattern of mortality of radiation exposure is described and used as an indication of why air exposure doses may be misleading. The therapy of radiation injury is described based on antibiotics, transfusion therapy, and use of molecular regulators. The limited role of matched allogenic bone marrow transplants is discussed. 52 refs., 13 figs.

Acute radiation syndrones and their management

International Nuclear Information System (INIS)

Cronkite, E.P.

1988-01-01

Radiation syndromes produced by large doses of ionizing radiation are divided into three general groups depending on dose of radiation and time after exposure. The CNS syndrome requires many thousands of rad, appears in minutes to hours, and kills within hours to days. The GIS appears after doses of a few hundred to 2000 rad. It is characterized by nausea, vomiting, diarrhea, and disturbances of water and electrolyte metabolism. It has a high mortality in the first week after exposure. Survivors will then experience the HS as a result of marrow aplasia. Depending on dose, survival is possible with antibiotic and transfusion therapy. The relationship of granulocyte depression to mortality in dogs and human beings is illustrated. The role of depth dose pattern of mortality of radiation exposure is described and used as an indication of why air exposure doses may be misleading. The therapy of radiation injury is described based on antibiotics, transfusion therapy, and use of molecular regulators. The limited role of matched allogenic bone marrow transplants is discussed. 52 refs., 13 figs

Delineating the deranged immune system in the antiphospholipid syndrome

NARCIS (Netherlands)

van den Hoogen, Lucas L.; van Roon, Joël A G; Radstake, Timothy R D J; Fritsch-Stork, Ruth D E; Derksen, Ronald H W M

2016-01-01

The antiphospholipid syndrome (APS) is a systemic autoimmune disease that is characterized serologically by the presence of antiphospholipid antibodies (aPL) and clinically by vascular thrombosis and obstetric complications. The protein β2 glycoprotein I (β2GPI) is identified as the most important

Distributed radiation data acquisition system for KAPP

International Nuclear Information System (INIS)

Narsaiah, A.; Anantakrishnan, T.S.; Bairi, B.R.

1992-01-01

Increased concern for the safety of personnel working in Nuclear Power Stations demands an efficient centralized Radiation Data Acquisition System (RADAS) to monitor different types of radiation at distributed locations of the plant. The system provides a comprehensive picture of radio-activity level distribution in the reactor building to facilitate prompt and correct decision making to take care of any emergency situation. The system is build around an industrial IBM-PC connected to remote intelligent data acquisition units using serial data communication links. To ensure high system availability and ease of maintenance the mechanical moving disk storage has been replaced by solid state memory storage (RAM Disk). Functional CRT displays have been substituted by the assembly of IBM-PC Mother Board with built-in firmware and standard TV Monitor. The computer handles a variety of processing functions which include the conversion to engineering units, checking of alarms, display/printing of plant radiation level status and system diagnostics. Intelligent terminals have been provided with graphic and text formatting capabilities. A hot standby computer connected to analog and digital inputs takes over the system functions on the failure of the host system. Modular software written in the higher level C-language runs under a standard real-time operating system Kernel. This provides for easy modification and expandability at site. Based on the experience of its commissioning at Kakrapar Power Station a new compact version is being designed for a specific application in another class of reactor. (author). 3 refs., 1 fig

An Interfacing System for Radiation Surveillance Using a Radio Communication Network

International Nuclear Information System (INIS)

Arunsiri, T.; Punnachaiya, S.; Pattarasumun, A.

1998-01-01

The development of an interfacing system for environmental radiation surveillance using radio communication network is aimed to improve a way by which environmental radiation measurement is transmitted and reported from the regional area monitoring station network. This also includes an automatic warning of beacon status via the radio link network to the center of environmental radiation control when an abnormal radiation level is detected. The interfacing system was developed by simulating the EGAT radio link network, the NT 2612, and can be separated into two parts. The first part was for a mobile station which can manage the output data from the radiation measurement system in the standard form of RS-232, IEEE-488, BCD and analog signal. This was accomplished by modulating the signal in selected baud rates ranging from 150 to 9600 bps using an economical radio packet capable of identifying and recalling the station code number. The other part is the linking system between the output data and the microcomputer equipped with a software to manage and evaluate the data from 10 surveillance stations for convenient handing of data output, statistical analysis and transmitting warning signal. Data transmission was tested using a baud rate of 1200 bps and was found to contain no detectable error when digital signal was transmitted while analog signal transmission resulted in deviations of less than ± 0.003%. The development of this radio link system provides a future trend for the environmental radiation monitoring network for countries with nuclear power plants or neighboring countries needed to continuously monitor for any abnormal radiation level in the environment. In case that the radiation surveillance system detects a high level of radiation, a warning signal will be transmitted and appropriate actions may be immediately exercised to control impacts of radiation on environment and living things according to international guidelines

Overview of different information about acute radiation syndrome among inhabitants around Chernobyl

International Nuclear Information System (INIS)

Yaroshinskaya, A.

1998-01-01

The Chernobyl nuclear catastrophe has divided scientists of the world, studying the consequences of its impact on the health of people, into two opposed, at times irreconcilable blocks. The first block generally comprises representatives of medical officials in the soviet and post-soviet society. They have been concealing the truth from the soviet and the world public for years. This group advocates the point of view that, except for firemen and several staff members who died at the time of the catastrophe, the Chernobyl accident has produced no practical impact on human health and will not do any such effect also in future. The second block consists basically of independent scientists. They are anxious about the facts of concealment of the truth on actual radiation doses, received by inhabitants of the areas around the Chernobyl NPP (ChNPP), as well as about impacts of low radiation dose on human health. Scientists of the second block are convinced that doses received by the population in the first days and months after the catastrophe at the ChNPP have played and will play significantly negative roles in worsening of human health years after the accident. The data on these doses have been deliberately concealed by the authorities from both the sufferers and the public. This fact has been already proven (by the Procurator General of the Ukraine as well). I have official and unofficial documents in my Chernobyl archive, which are demonstrating two approaching ways to the problems of radiological consequences due to the Chernobyl catastrophe. I would like to emphasize that these documents have never been published anywhere. In searching the answer to the question about the acute radiation syndrome among inhabitants in the areas around the Chernobyl NPP in the first weeks and months after the catastrophe, we will compare positions, arguments and conclusions of two blocks based on the facts presented in these documents. (author)

Medical Response in Radiation Emergency in Argentina

International Nuclear Information System (INIS)

Vazquez, M.A.; Tadic, M.M.

2011-01-01

According to the Nuclear Federal Law No. 24804, the Nuclear Regulatory Authority (ARN) is empowered to regulate and control the nuclear activity with regard to radiological and nuclear safety, physical protection and nuclear non-proliferation issues. ARN has a system for intervention in radiological -and nuclear emergencies with a primary intervention group, which is on duty in weekly shifts all year round. This paper aims at describing the system as implemented at present. The Emergency Medical System has been developed into three levels: Level I: local emergency services. This level includes triage (conventional and radiological), first-aid care, and first management of contaminated victims Level II: emergency departments of local general hospitals that are in charge of performing a second triage by a biomedical approach, the treatment of conventional and/or radiocombined injuries and completing decontamination as necessary. In this way the initial triage is completed by a physical examination, timing and severity of prodromal signs and symptoms, sequential blood counts and serum enzymatic levels that allow a first-stage dosimetric approach at this level. Victims requiring higher complexity assistance shall be transferred to third-level hospitals. Level III: three central reference hospitals (Hospital Naval 'Pedro Mallo', Hospital de Quemados from Gobierno Autonomo de la Ciudad de Buenos Aires and Hospital Britanico de Ciudad de Buenos Aires) capable of providing healthcare for diagnosis and treatment of acute radiation syndrome, cutaneous radiation syndrome and internal contamination constitute this level. An educational program for medical and paramedical responders is regularly carried out at the three levels, including theoretical background as well as practical training. Guidelines and protocols for medical handling of victims have been drawn up. Research and development of new strategies for first medical response, diagnosis and treatment of radiation

Medical response in radiation emergency in Argentina

International Nuclear Information System (INIS)

Vazquez, Marina A.; Tadic, Maria M.

2008-01-01

According to the Nuclear Federal Law Nr. 24804, the Nuclear Regulatory Authority (ARN) is empowered to regulate and control the nuclear activity with regard to radiological and nuclear safety, physical protection and nuclear non-proliferation issues. ARN has a system for intervention in radiological -and nuclear emergencies with a primary intervention group, which is on duty in weekly shifts all year round. This paper aims at describing the system as implemented at present. The Emergency Medical System has been developed into three levels: Level I: local emergency services. This level includes triage (conventional and radiological), first-aid care, and first management of contaminated victims. Level II: Emergency departments of local general hospitals that are in charge of performing a second triage by a biomedical approach, the treatment of conventional and/or radio-combined injuries and completing decontamination as necessary. In this way the initial triage is completed by a physical examination, timing and severity of prodromal signs and symptoms, sequential blood counts and serum enzymatic levels that allow a first-stage dosimetric approach at this level. Victims requiring higher complexity assistance shall be transferred to third-level hospitals. Level III: three central reference hospitals (Hospital Naval 'Pedro Mallo', Hospital de Quemados from Gobierno Autonomo de la Ciudad de Buenos Aires and Hospital Britanico de Ciudad de Buenos Aires) capable of providing health care for diagnosis and treatment of acute radiation syndrome, cutaneous radiation syndrome and internal contamination constitute this level. An educational program for medical and paramedical responders is regularly carried out at the three levels, including theoretical background as well as practical training. Guidelines and protocols for medical handling of victims have been drawn up. Research and development of new strategies for first medical response, diagnosis and treatment of radiation

Rational system of radiation dosimetry

International Nuclear Information System (INIS)

Katoh, K.; Tada, J.

1996-01-01

Radiation doses are the most important subject to the sciences relating to the effects of ionizing radiation on matter. Since any science at all must stand on the quantitative description of causality, uses of physical quantities as the measures are indispensable. The current system of radiation dosimetry is built on the fundamental dose of the absorbed dose, which is defined as the 'energy imparted' density, and for practical convenience various weighted absorbed doses are introduced as subsidiary. However, it has been pointed out that these quantities lack adequacy inherently as a measure of causes, in addition to the insufficiency of the specification of the concept. Firstly, separation of the quantities of radiation field and of the dose is not possible, since both quantities are deeply related to the same microscopic constituents, i.e., electrons. Secondly, the value of the absorbed dose cannot be fixed at the moment of irradiation. Since the absorbed dose is a quantity of interaction product of radiation and matter, the values of the dose cannot be fixed instantaneously. Thirdly, it is not easy to envision the physical entity of the quantity from the definition. The form of existence of the 'imparted' energy is not clear in the current definition. These defects can not be removed as long as an interaction product is adopted as the dose quantity. In this paper, the authors present a prescription to solve these problems. (author)

Radiation safety management system in a radioactive facility

International Nuclear Information System (INIS)

Amador, Zayda H.

2008-01-01

Full text: This paper illustrates the Cuban experience in implementing and promoting an effective radiation safety system for the Centre of Isotopes, the biggest radioactive facility of our country. Current management practice demands that an organization inculcate culture of safety in preventing radiation hazard. The aforementioned objectives of radiation protection can only be met when it is implemented and evaluated continuously. Commitment from the workforce to treat safety as a priority and the ability to turn a requirement into a practical language is also important to implement radiation safety policy efficiently. Maintaining and improving safety culture is a continuous process. There is a need to establish a program to measure, review and audit health and safety performance against predetermined standards. All those areas of the radiation protection program are considered (e.g. licensing and training of the staff, occupational exposure, authorization of the practices, control of the radioactive material, radiological occurrences, monitoring equipment, radioactive waste management, public exposure due to airborne effluents, audits and safety costs). A set of indicators designed to monitor key aspects of operational safety performance are used. Their trends over a period of time are analyzed with the modern information technologies, because this can provide an early warning to plant management for searching causes behind the observed changes. In addition to analyze the changes and trends, these indicators are compared against identified targets and goals to evaluate performance strengths and weaknesses. A structured and proper radiation self-auditing system is seen as a basic requirement to meet the current and future needs in sustainability of radiation safety. The integrated safety management system establishment has been identified as a goal and way for the continuous improvement. (author)

Practicing radiation oncology in the current health care environment - Part III: Information systems for radiation oncology practice

International Nuclear Information System (INIS)

Kijewski, Peter

1996-01-01

Purpose: This course will review topics to be considered when defining an information systems plan for a department of radiation oncology. A survey of available systems will be presented. Computer information systems can play an important role in the effective administration and operation of a department of radiation oncology. Tasks such as 1) scheduling for physicians, patients, and rooms, 2) charge collection and billing, 3) administrative reporting, and 4) treatment verification can be carried out efficiently with the assistance of computer systems. Operating a department without a state of art computer system will become increasingly difficult as hospitals and healthcare buyers increasingly rely on computer information technology. Communication of the radiation oncology system with outside systems will thus further enhance the utility of the computer system. The steps for the selection and installation of an information system will be discussed: 1) defining the objectives, 2) selecting a suitable system, 3) determining costs, 4) setting up maintenance contracts, and 5) planning for future upgrades

Use of lymphoblastoid cell lines to evaluate the hypersensitivity to ultraviolet radiation in Cockayne syndrome

International Nuclear Information System (INIS)

Otsuka, F.; Tarone, R.E.; Cayeux, S.; Robbins, J.H.

1984-01-01

Cockayne syndrome (CS) is a rare autosomal recessive disease characterized by acute sun sensitivity, cachectic dwarfism, and neurologic and skeletal abnormalities. Cultured skin fibroblasts from patients with this disease are known to be hypersensitive to the lethal effects of 254-nm UV radiation. The authors have studied the sensitivity of 254-nm UV radiation of lymphoblastoid lines derived from 3 typical CS patients, 1 atypical CS patient who had a very late age of onset of clinical manifestations, 2 patients who had both xeroderma pigmentosum (XP) and typical CS, and 3 heterozygous parents of these patients. Post-UV survival was determined by the trypan-blue dye-exclusion method. The lymphoblastoid lines from the 3 typical CS patients, the atypical CS patient, and the 2 patients with both CS and XP had decreased post-UV viability in comparison with lines from normal donors. Lines from the heterozygous parents had normal post-UV viability. The post-UV viability of the typical CS lines was similar to that of a XP complementation group C line. The relative post-UV viability of lymphoblastoid lines from the typical CS patients was similar to the relative post-UV survival of their fibroblast lines. The lymphoblastoid line from the atypical CS patient had a post-UV viability similar to that of the typical CS patients. Thus, the relative hypersensitivity of CS patients cells in vitro does not reflect the severity or age of onset of the patients clinical manifestations. The lymphoblastoid lines from the 2 patients who had both CS and XP were significantly more sensitive to the UV radiation than those from patients with only CS. Our studies demonstrate that lymphoblastoid lines from patients with CS are appropriate and useful cell lines for the study of the inherited hypersensitivity to UV radiation

The Gottingen Minipig Is a Model of the Hematopoietic Acute Radiation Syndrome: G-Colony Stimulating Factor Stimulates Hematopoiesis and Enhances Survival From Lethal Total-Body γ-Irradiation

Energy Technology Data Exchange (ETDEWEB)

Moroni, Maria, E-mail: maria.moroni@usuhs.edu [Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland (United States); Ngudiankama, Barbara F. [Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland (United States); Christensen, Christine [Division of Comparative Pathology, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland (United States); Olsen, Cara H. [Biostatistics Consulting Center, Uniformed Services University of the Health Sciences, Bethesda, Maryland (United States); Owens, Rossitsa [Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland (United States); Lombardini, Eric D. [Veterinary Medicine Department, Armed Forces Research Institute of Medical Sciences, Bangkok (Thailand); Holt, Rebecca K. [Veterinary Science Department, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland (United States); Whitnall, Mark H. [Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland (United States)

2013-08-01

Purpose: We are characterizing the Gottingen minipig as an additional large animal model for advanced drug testing for the acute radiation syndrome (ARS) to enhance the discovery and development of novel radiation countermeasures. Among the advantages provided by this model, the similarities to human hematologic parameters and dynamics of cell loss/recovery after irradiation provide a convenient means to compare the efficacy of drugs known to affect bone marrow cellularity and hematopoiesis. Methods and Materials: Male Gottingen minipigs, 4 to 5 months old and weighing 9 to 11 kg, were used for this study. We tested the standard off-label treatment for ARS, rhG-CSF (Neupogen, 10 μg/kg/day for 17 days), at the estimated LD70/30 total-body γ-irradiation (TBI) radiation dose for the hematopoietic syndrome, starting 24 hours after irradiation. Results: The results indicated that granulocyte colony stimulating factor (G-CSF) enhanced survival, stimulated recovery from neutropenia, and induced mobilization of hematopoietic progenitor cells. In addition, the administration of G-CSF resulted in maturation of monocytes/macrophages. Conclusions: These results support continuing efforts toward validation of the minipig as a large animal model for advanced testing of radiation countermeasures and characterization of the pathophysiology of ARS, and they suggest that the efficacy of G-CSF in improving survival after total body irradiation may involve mechanisms other than increasing the numbers of circulating granulocytes.

The Gottingen minipig is a model of the hematopoietic acute radiation syndrome: G-colony stimulating factor stimulates hematopoiesis and enhances survival from lethal total-body γ-irradiation.

Science.gov (United States)

Moroni, Maria; Ngudiankama, Barbara F; Christensen, Christine; Olsen, Cara H; Owens, Rossitsa; Lombardini, Eric D; Holt, Rebecca K; Whitnall, Mark H

2013-08-01

We are characterizing the Gottingen minipig as an additional large animal model for advanced drug testing for the acute radiation syndrome (ARS) to enhance the discovery and development of novel radiation countermeasures. Among the advantages provided by this model, the similarities to human hematologic parameters and dynamics of cell loss/recovery after irradiation provide a convenient means to compare the efficacy of drugs known to affect bone marrow cellularity and hematopoiesis. Male Gottingen minipigs, 4 to 5 months old and weighing 9 to 11 kg, were used for this study. We tested the standard off-label treatment for ARS, rhG-CSF (Neupogen, 10 μg/kg/day for 17 days), at the estimated LD70/30 total-body γ-irradiation (TBI) radiation dose for the hematopoietic syndrome, starting 24 hours after irradiation. The results indicated that granulocyte colony stimulating factor (G-CSF) enhanced survival, stimulated recovery from neutropenia, and induced mobilization of hematopoietic progenitor cells. In addition, the administration of G-CSF resulted in maturation of monocytes/macrophages. These results support continuing efforts toward validation of the minipig as a large animal model for advanced testing of radiation countermeasures and characterization of the pathophysiology of ARS, and they suggest that the efficacy of G-CSF in improving survival after total body irradiation may involve mechanisms other than increasing the numbers of circulating granulocytes. Published by Elsevier Inc.

The Gottingen Minipig Is a Model of the Hematopoietic Acute Radiation Syndrome: G-Colony Stimulating Factor Stimulates Hematopoiesis and Enhances Survival From Lethal Total-Body γ-Irradiation

International Nuclear Information System (INIS)

Moroni, Maria; Ngudiankama, Barbara F.; Christensen, Christine; Olsen, Cara H.; Owens, Rossitsa; Lombardini, Eric D.; Holt, Rebecca K.; Whitnall, Mark H.

2013-01-01

Purpose: We are characterizing the Gottingen minipig as an additional large animal model for advanced drug testing for the acute radiation syndrome (ARS) to enhance the discovery and development of novel radiation countermeasures. Among the advantages provided by this model, the similarities to human hematologic parameters and dynamics of cell loss/recovery after irradiation provide a convenient means to compare the efficacy of drugs known to affect bone marrow cellularity and hematopoiesis. Methods and Materials: Male Gottingen minipigs, 4 to 5 months old and weighing 9 to 11 kg, were used for this study. We tested the standard off-label treatment for ARS, rhG-CSF (Neupogen, 10 μg/kg/day for 17 days), at the estimated LD70/30 total-body γ-irradiation (TBI) radiation dose for the hematopoietic syndrome, starting 24 hours after irradiation. Results: The results indicated that granulocyte colony stimulating factor (G-CSF) enhanced survival, stimulated recovery from neutropenia, and induced mobilization of hematopoietic progenitor cells. In addition, the administration of G-CSF resulted in maturation of monocytes/macrophages. Conclusions: These results support continuing efforts toward validation of the minipig as a large animal model for advanced testing of radiation countermeasures and characterization of the pathophysiology of ARS, and they suggest that the efficacy of G-CSF in improving survival after total body irradiation may involve mechanisms other than increasing the numbers of circulating granulocytes

Radiation induced peroxidation in model lipid systems

International Nuclear Information System (INIS)

Dahlan, K.Z.B.H.M.

1981-08-01

In the studies of radiation induced lipid peroxidation, lecithin-liposomes and aqueous micellar solutions of sodium linoleate (or linoleic acid) have been used as models of lipid membrane systems. The liposomes and aqueous linoleate micelles were irradiated in the presence of O 2 and N 2 O/O 2 (80/20 v/v). The peroxidation was initiated using gamma radiation from 60 Co radiation source and was monitored by measuring the increase in absorbance of conjugated diene at 232 nm and by the thiobarbituric acid (TBA) test. The oxidation products were also identified by GLC and GLC-MS analysis. (author)

Modification of GNPS environment radiation monitoring network system

International Nuclear Information System (INIS)

Jiang Lili; Cao Chunsheng

1999-01-01

GNPS Environment Radiation Continuous Monitoring System (KRS), the only real time on-line system of site radiation monitoring, was put into service in 1993 prior to the first loading the the plant. It is revealed through several years of operation that this system has some deficiencies such as inadequate real time monitoring means, no figure and diagram display function on the central computer, high failures, frequent failure warning signals, thus making the availability of the system at a low level. In recent years, with the rapid development of computer network technology and increasingly strict requirements on the NPP environment protection raised by the government and public, KRS modification had become necessary and urgent. In 1996, GNPS carried out modification work on the measuring geometry condition of γ radiation monitoring sub-station and lightening protection. To enhance the functions of real time monitoring and data auto-processing, further modification of the system was made in 1998, including the update of the software and hardware of KRS central processor, set-up of system computer local network and database. In this way, the system availability and monitoring quality are greatly improved and effective monitoring and analysis means are provided for gaseous release during normal operation and under accident condition

SORIS—A standoff radiation imaging system

Science.gov (United States)

Zelakiewicz, Scott; Hoctor, Ralph; Ivan, Adrian; Ross, William; Nieters, Edward; Smith, William; McDevitt, Daniel; Wittbrodt, Michael; Milbrath, Brian

2011-10-01

The detection of radiological and special nuclear material within the country's borders is a crucial component of the national security network. Being able to detect small amounts of radiological material at large distances is especially important for search applications. To provide this capability General Electric's Research Center has developed, as a part of DNDO's standoff radiation detection system advanced technology demonstration (SORDS-ATD) program, a standoff radiation imaging system (SORIS). This vehicle-based system is capable of detecting weak sources at large distances in relatively short times. To accomplish this, GE has developed a novel coded aperture detector based on commercial components from GE Healthcare. An array of commercial gamma cameras modified to increase the system efficiency and energy range are used as position sensitive detectors. Unlike typical coded aperture systems, however, SORIS employs a non-planar mask and thus does not suffer the typical limitations of partially encoded regions giving it a wide field of view. Source identification is done using both low-statistics anomaly indicators and conventional high-statistics algorithms being developed by Pacific Northwest National Laboratory. The results of scanned areas and threats identified are displayed to the user and overlaid on satellite imagery.

SORIS-A standoff radiation imaging system

International Nuclear Information System (INIS)

Zelakiewicz, Scott; Hoctor, Ralph; Ivan, Adrian; Ross, William; Nieters, Edward; Smith, William; McDevitt, Daniel; Wittbrodt, Michael; Milbrath, Brian

2011-01-01

The detection of radiological and special nuclear material within the country's borders is a crucial component of the national security network. Being able to detect small amounts of radiological material at large distances is especially important for search applications. To provide this capability General Electric's Research Center has developed, as a part of DNDO's standoff radiation detection system advanced technology demonstration (SORDS-ATD) program, a standoff radiation imaging system (SORIS). This vehicle-based system is capable of detecting weak sources at large distances in relatively short times. To accomplish this, GE has developed a novel coded aperture detector based on commercial components from GE Healthcare. An array of commercial gamma cameras modified to increase the system efficiency and energy range are used as position sensitive detectors. Unlike typical coded aperture systems, however, SORIS employs a non-planar mask and thus does not suffer the typical limitations of partially encoded regions giving it a wide field of view. Source identification is done using both low-statistics anomaly indicators and conventional high-statistics algorithms being developed by Pacific Northwest National Laboratory. The results of scanned areas and threats identified are displayed to the user and overlaid on satellite imagery.

Standardization of penetrating radiation testing system

International Nuclear Information System (INIS)

Wiley, P.A.; Aronson, H.L.

1979-01-01

Standardization is provided to control system gain of a penetrating radiation testing system by periodically inspecting a reference object in the same manner as the product samples so as to generate a stabilization signal which is compared to a reference signal. The difference, if any, between the stabilization signal and the reference signal is integrated and the integrated signal is used to correct the gain of the system

High Temperature Radiators for Electric Propulsion Systems, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — The VASIMR propulsion system uses a high temperature Loop Heat Pipe (LHP) radiator to reject heat from the helicon section. The current baseline radiator uses...

Evolution of the radiation protection system; L'evolution du systeme de protection radiologique

Energy Technology Data Exchange (ETDEWEB)

Clarke, R.H. [International Commission on Radiological Protection, Stockholm (Sweden); Schieber, C.; Cordoliani, Y.S. [Societe Francaise de Radioprotection, 92 - Fontenay aux Roses (France); Brechignac, F. [CEA Cadarache, Institut de Radioprotection et de Surete Nucleaire, Dept. de Protection de l' Environnement, 13 - Saint Paul Lez Durance (France)

2003-07-01

The evolution of the system of radiological protection: justification for new ICRP recommendations, thoughts of the SFRP work group about the evolution of the system of radiation protection proposed by the ICRP, protection of environment against ionizing radiations seen by the ICRP are the three parts of this chapter. (N.C.)

Radiation-induced acute necrosis of the pancreatic islet and the diabetic syndrome in the golden hamster (Mesocricetus auratus)

Energy Technology Data Exchange (ETDEWEB)

Tsubouchi, S; Suzuki, H; Ariyoshi, H [Aichi Cancer Center, Nagoya (Japan); Matsuzawa, T [Tohoku Univ., Sendai (Japan). Research Inst. for Tuberculosis and Cancer

1981-07-01

Exposure of golden hamsters to 35 000 rad of X-rays induced acute and specific necrosis of the cells of the islets of Langerhans of the pancreas within 4 hours, whereas no other tissue revealed any drastic changes which would lead to a critical illness until 36 hours. Animals began to show the characteristic signs of diabetes, that is, hyperglycaemia, hyperkalaemia, ketonemia, and acidosis at 12 hours and these continued until death, 56+-8 hours later. These were accompanied by the disappearance of ..beta..-cell granules and a decrease of plasma insulin. Treatment of irradiated animals with injections of insulin resulted in a reduction in high blood glucose and the prolongation of survival time up to 5 days, which is comparable to the survival time when the cause of death is gastrointestinal. It is concluded that this radiation-induced diabetic syndrome resulted from acute necrosis of the cells of the islets of Langerhans, a previously unreported lethal effect of radiation in golden hamsters.

GSM module for wireless radiation monitoring system via SMS

Science.gov (United States)

Rahman, Nur Aira Abd; Hisyam Ibrahim, Noor; Lombigit, Lojius; Azman, Azraf; Jaafar, Zainudin; Arymaswati Abdullah, Nor; Hadzir Patai Mohamad, Glam

2018-01-01

A customised Global System for Mobile communication (GSM) module is designed for wireless radiation monitoring through Short Messaging Service (SMS). This module is able to receive serial data from radiation monitoring devices such as survey meter or area monitor and transmit the data as text SMS to a host server. It provides two-way communication for data transmission, status query, and configuration setup. The module hardware consists of GSM module, voltage level shifter, SIM circuit and Atmega328P microcontroller. Microcontroller provides control for sending, receiving and AT command processing to GSM module. The firmware is responsible to handle task related to communication between device and host server. It process all incoming SMS, extract, and store new configuration from Host, transmits alert/notification SMS when the radiation data reach/exceed threshold value, and transmits SMS data at every fixed interval according to configuration. Integration of this module with radiation survey/monitoring device will create mobile and wireless radiation monitoring system with prompt emergency alert at high-level radiation.

Successful Teaching of Radiobiology Students in the Medical Management of Acute Radiation Effects From Real Case Histories Using Clinical Signs and Symptoms and Taking Advantage of Recently Developed Software Tools.

Science.gov (United States)

Majewski, Matthäus; Combs, Stephanie E; Trott, Klaus-Rüdiger; Abend, Michael; Port, Matthias

2018-07-01

In 2015, the Bundeswehr Institute of Radiobiology organized a North Atlantic Treaty Organization exercise to examine the significance of clinical signs and symptoms for the prediction of late-occurring acute radiation syndrome. Cases were generated using either the Medical Treatment Protocols for Radiation Accident Victims (METREPOL, n = 167) system or using real-case descriptions extracted from a database system for evaluation and archiving of radiation accidents based on case histories (SEARCH, n = 24). The cases ranged from unexposed [response category 0 (RC 0, n = 89)] to mild (RC 1, n = 45), moderate (RC 2, n = 19), severe (RC 3, n = 20), and lethal (RC 4, n = 18) acute radiation syndrome. During the previous exercise, expert teams successfully predicted hematological acute radiation syndrome severity, determined whether hospitalization was required, and gave treatment recommendations, taking advantage of different software tools developed by the North Atlantic Treaty Organization teams. The authors provided the same data set to radiobiology students who were introduced to the medical management of acute effects after radiation exposure and the software tools during a class lasting 15 h. Corresponding to the previous results, difficulties in the discrimination between RC 0/RC 1 and RC 3/RC 4, as well as a systematic underestimation of RC 1 and RC 2, were observed. Nevertheless, after merging reported response categories into clinically relevant groups (RC 0-1, RC 2-3, and RC 3-4), it was found that the majority of cases (95.2% ± 2.2 standard deviations) were correctly identified and that 94.7% (±2.6 standard deviations) developing acute radiation syndrome and z96.4% (±1.6 standard deviations) requiring hospitalization were identified correctly. Two out of three student teams also provided a dose estimate. These results are comparable to the best-performing team of the 2015 North Atlantic Treaty Organization exercise (response category: 92.5%; acute

Drug delivery system and radiation therapy

International Nuclear Information System (INIS)

Shibata, Tokushi

2005-01-01

This paper describes the review of radiation therapy, neutron capture therapy (NCT) and drug delivery system for the latter. In cancer radiation therapy, there are problems of body movement like breathing, needless irradiation of normal tissues, difficulty to decide the correct irradiation position and tumor morphology. NCT has advantages to overcome these, and since boron has a big cross section for thermal neutron, NPT uses the reaction 10 B(n, α) 7 Li in the target cancer which previously incorporated the boron-containing drug. During the period 1966-1996, 246 patients were treated with this in Japan and the treatment has been continued thereafter. The tasks for NCT are developments of drug delivery system efficient to deliver the drug into the tumor and of convenient neutron source like the accelerator. (S.I.)

Space Radiation and Risks to Human Health

Science.gov (United States)

Huff, Janice L.; Patel, Zarana S.; Simonsen, Lisa C.

2014-01-01

The radiation environment in space poses significant challenges to human health and is a major concern for long duration manned space missions. Outside the Earth's protective magnetosphere, astronauts are exposed to higher levels of galactic cosmic rays, whose physical characteristics are distinct from terrestrial sources of radiation such as x-rays and gamma-rays. Galactic cosmic rays consist of high energy and high mass nuclei as well as high energy protons; they impart unique biological damage as they traverse through tissue with impacts on human health that are largely unknown. The major health issues of concern are the risks of radiation carcinogenesis, acute and late decrements to the central nervous system, degenerative tissue effects such as cardiovascular disease, as well as possible acute radiation syndromes due to an unshielded exposure to a large solar particle event. The NASA Human Research Program's Space Radiation Program Element is focused on characterization and mitigation of these space radiation health risks along with understanding these risks in context of the other biological stressors found in the space environment. In this overview, we will provide a description of these health risks and the Element's research strategies to understand and mitigate these risks.

Maintenance of radiation safety information system

Energy Technology Data Exchange (ETDEWEB)

Choi, Ho Sun [Korea Institute of Nuclear Safety, Taejon (Korea, Republic of); Park, Moon Il; Chung, Chong Kyu; Lim, Bock Soo; Kim, Hyung Uk; Chang, Kwang Il; Nam, Kwan Hyun; Cho, Hye Ryan [AD center incubation LAB, Taejon (Korea, Republic of)

2001-12-15

The objectives of radiation safety information system maintenance are to maintain the requirement of users, change of job process and upgrade of the system performance stably and effectively while system maintenance. We conduct the code of conduct recommended by IAEA, management of radioisotope inventory database systematically using analysis for the state of inventory database integrated in this system. This system and database will be support the regulatory guidance, rule making and information to the MOST, KINS, other regulatory related organization and general public optimizationally.

Multilevel mechanisms of stimulatory effect of low dose radiation on immunity

International Nuclear Information System (INIS)

Shu-Zeng Liu

1992-01-01

Attention is paid to the effects of low level ionizing radiation on humans. The conference is devoted to low dose radiation and defense mechanisms of the body. Due to the importance of the immune system in body resistance, special attention has been given to host defense mechanisms following exposure to different doses of ionizing radiation. The immune system has long been known to be highly sensitive to moderate to high doses of ionizing radiation with immuno-depression as one of the most important causes of death in acute radiation syndrome. However, the dose-effect relationship of immune functions has been found to be quite different in the low dose range, especially with doses within 0.1 Gy. With doses above 0.5 Gy most immunologic parameters show a dose dependent depression. With doses between 0.1-0.5 Gy there may be no definite changes in immune functions. Doses within 0.1 Gy, given in single or chronic exposures, have been found to stimulate many immune responses. (author). 16 refs., 2 figs., 7 tabs

Quality control of gamma radiation measuring systems

International Nuclear Information System (INIS)

Surma, M.J.

2002-01-01

The problem of quality control and assurance of gamma radiation measuring systems has been described in detail. The factors deciding of high quality of radiometric measurements as well as statistical testing and calibration of measuring systems have been presented and discussed

Proposed alternatives for a DOE-wide occupational radiation exposure information system

International Nuclear Information System (INIS)

Murphy, B.L.; Murphy, D.W.; Fix, J.J.; Selby, J.M.; Vallario, E.J.

1984-02-01

The Radiation Exposure Information Reporting System (REIRS) was initiated by the Atomic Energy Commission (AEC) in 1968. While the system has provided a general overview of radiation exposures associated with AEC/ERDA/DOE operations and has satisfied the original intent for a central information system, the need for more detailed information has become evident. The alternatives addressed for a radiation exposure information system were no change in current system, clarification of DOE Order for current system, increased summary information from sites, centralized annual individual dose (exposure) system, and annual dose summary and locator files. A majority of the DOE Ad Hoc Committee has concurred to recommend the annual dose summary and locator files (ADSLF). The acceptance of the ADSLF alternative as the DOE-wide radiation exposure system would give DOE added capability and flexibility in responding to requests for information and would reduce the impact on the sites of special survey requests

Radiation Monitoring System in Advanced Spent Fuel Conditioning Process Facility

Energy Technology Data Exchange (ETDEWEB)

You, Gil Sung; Kook, D. H.; Choung, W. M.; Ku, J. H.; Cho, I. J.; You, G. S.; Kwon, K. C.; Lee, W. K.; Lee, E. P

2006-09-15

The Advanced spent fuel Conditioning Process is under development for effective management of spent fuel by converting UO{sub 2} into U-metal. For demonstration of this process, {alpha}-{gamma} type new hot cell was built in the IMEF basement . To secure against radiation hazard, this facility needs radiation monitoring system which will observe the entire operating area before the hot cell and service area at back of it. This system consists of 7 parts; Area Monitor for {gamma}-ray, Room Air Monitor for particulate and iodine in both area, Hot cell Monitor for hot cell inside high radiation and rear door interlock, Duct Monitor for particulate of outlet ventilation, Iodine Monitor for iodine of outlet duct, CCTV for watching workers and material movement, Server for management of whole monitoring system. After installation and test of this, radiation monitoring system will be expected to assist the successful ACP demonstration.

Radiation Monitoring System in Advanced Spent Fuel Conditioning Process Facility

International Nuclear Information System (INIS)

You, Gil Sung; Kook, D. H.; Choung, W. M.; Ku, J. H.; Cho, I. J.; You, G. S.; Kwon, K. C.; Lee, W. K.; Lee, E. P.

2006-09-01

The Advanced spent fuel Conditioning Process is under development for effective management of spent fuel by converting UO 2 into U-metal. For demonstration of this process, α-γ type new hot cell was built in the IMEF basement . To secure against radiation hazard, this facility needs radiation monitoring system which will observe the entire operating area before the hot cell and service area at back of it. This system consists of 7 parts; Area Monitor for γ-ray, Room Air Monitor for particulate and iodine in both area, Hot cell Monitor for hot cell inside high radiation and rear door interlock, Duct Monitor for particulate of outlet ventilation, Iodine Monitor for iodine of outlet duct, CCTV for watching workers and material movement, Server for management of whole monitoring system. After installation and test of this, radiation monitoring system will be expected to assist the successful ACP demonstration

Effect of ionizing radiation on moist air systems

International Nuclear Information System (INIS)

Reed, D.T.; Van Konynenburg, R.A.

1987-01-01

The radiation chemistry of nitrogen/oxygen/water systems is reviewed. General radiolytic effects in dry nitrogen/oxygen systems are relatively well characterized. Irradiation results in the formation of steady state concentrations of ozone, nitrous oxide and nitrogen dioxide. In closed systems, the concentration observed depends on the total dose, temperature and initial gas composition. Only three studies have been published that focus on the radiation chemistry of nitrogen/oxygen/water homogeneous gas systems. Mixed phase work that is relevant to the gaseous system is also summarized. The presence of water vapor results in the formation of nitric acid and significantly changes the chemistry observed in dry air systems. Mechanistic evidence from the studies reviewed are summarized and discussed in relation to characterizing the gas phase during the containment period of a repository in tuff

The development of remote wireless radiation dose monitoring system

Energy Technology Data Exchange (ETDEWEB)

Lee, Jin-woo [KAERI - Korea Atomic Energy Research Institute, Jeongup-si (Korea, Republic of); Chonbuk National University, Jeonjoo-Si (Korea, Republic of); Jeong, Kyu-hwan [KINS - Korea Institute of Nuclear Safety, Daejeon-Si (Korea, Republic of); Kim, Jong-il [Chonbuk National University, Jeonjoo-Si (Korea, Republic of); Im, Chae-wan [REMTECH, Seoul-Si (Korea, Republic of)

2015-07-01

Internet of things (IoT) technology has recently shown a large flow of IT trends in human life. In particular, our lives are now becoming integrated with a lot of items around the 'smart-phone' with IoT, including Bluetooth, Near Field Communication (NFC), Beacons, WiFi, and Global Positioning System (GPS). Our project focuses on the interconnection of radiation dosimetry and IoT technology. The radiation workers at a nuclear facility should hold personal dosimeters such as a Thermo-Luminescence Dosimeter (TLD), an Optically Stimulated Luminescence Dosimeter (OSL), pocket ionization chamber dosimeters, an Electronic Personal Dosimeter (EPD), or an alarm dosimeter on their body. Some of them have functions that generate audible or visible alarms to radiation workers in a real working area. However, such devices used in radiation fields these days have no functions for communicating with other areas or the responsible personnel in real time. In particular, when conducting a particular task in a high dose area, or a number of repair works within a radiation field, radiation dose monitoring is important for the health of the workers and the work efficiency. Our project aims at the development of a remote wireless radiation dose monitoring system (RWRD) that can be used to monitor the radiation dose in a nuclear facility for radiation workers and a radiation protection program In this project, a radiation dosimeter is the detection device for personal radiation dose, a smart phone is the mobile wireless communication tool, and, Beacon is the wireless starter for the detection, communication, and position of the worker using BLE (Bluetooth Low Energy). In this report, we report the design of the RWRD and a demonstration case in a real radiation field. (authors)

The development of remote wireless radiation dose monitoring system

International Nuclear Information System (INIS)

Lee, Jin-woo; Jeong, Kyu-hwan; Kim, Jong-il; Im, Chae-wan

2015-01-01

Internet of things (IoT) technology has recently shown a large flow of IT trends in human life. In particular, our lives are now becoming integrated with a lot of items around the 'smart-phone' with IoT, including Bluetooth, Near Field Communication (NFC), Beacons, WiFi, and Global Positioning System (GPS). Our project focuses on the interconnection of radiation dosimetry and IoT technology. The radiation workers at a nuclear facility should hold personal dosimeters such as a Thermo-Luminescence Dosimeter (TLD), an Optically Stimulated Luminescence Dosimeter (OSL), pocket ionization chamber dosimeters, an Electronic Personal Dosimeter (EPD), or an alarm dosimeter on their body. Some of them have functions that generate audible or visible alarms to radiation workers in a real working area. However, such devices used in radiation fields these days have no functions for communicating with other areas or the responsible personnel in real time. In particular, when conducting a particular task in a high dose area, or a number of repair works within a radiation field, radiation dose monitoring is important for the health of the workers and the work efficiency. Our project aims at the development of a remote wireless radiation dose monitoring system (RWRD) that can be used to monitor the radiation dose in a nuclear facility for radiation workers and a radiation protection program In this project, a radiation dosimeter is the detection device for personal radiation dose, a smart phone is the mobile wireless communication tool, and, Beacon is the wireless starter for the detection, communication, and position of the worker using BLE (Bluetooth Low Energy). In this report, we report the design of the RWRD and a demonstration case in a real radiation field. (authors)