Supporting Calculations For Submerged Bed Scrubber Condensate Disposal Preconceptual Study

International Nuclear Information System (INIS)

Pajunen, A. J.; Tedeschi, A. R.

2012-01-01

This document provides supporting calculations for the preparation of the Submerged Bed Scrubber Condensate Disposal Preconceptual Study report. The supporting calculations include equipment sizing, Hazard Category determination, and LAW Melter Decontamination Factor Adjustments

Supporting Calculations For Submerged Bed Scrubber Condensate Disposal Preconceptual Study

Energy Technology Data Exchange (ETDEWEB)

Pajunen, A. J.; Tedeschi, A. R.

2012-09-18

This document provides supporting calculations for the preparation of the Submerged Bed Scrubber Condensate Disposal Preconceptual Study report The supporting calculations include equipment sizing, Hazard Category determination, and LAW Melter Decontamination Factor Adjustments.

AHTR Mechanical, Structural, and Neutronic Preconceptual Design

Energy Technology Data Exchange (ETDEWEB)

Varma, V.K.; Holcomb, D.E.; Peretz, F.J.; Bradley, E.C.; Ilas, D.; Qualls, A.L.; Zaharia, N.M.

2012-09-15

This report provides an overview of the mechanical, structural, and neutronic aspects of the Advanced High Temperature Reactor (AHTR) design concept. The AHTR is a design concept for a large output Fluoride salt cooled High-temperature Reactor (FHR) that is being developed to enable evaluation of the technology hurdles remaining to be overcome prior to FHRs becoming an option for commercial reactor deployment. This report documents the incremental AHTR design maturation performed over the past year and is focused on advancing the design concept to a level of a functional, self-consistent system. The reactor concept development remains at a preconceptual level of maturity. While the overall appearance of an AHTR design is anticipated to be similar to the current concept, optimized dimensions will differ from those presented here. The AHTR employs plate type coated particle fuel assemblies with rapid, off-line refueling. Neutronic analysis of the core has confirmed the viability of a 6-month two-batch cycle with 9 wt. % enriched uranium fuel. Refueling is intended to be performed automatically under visual guidance using dedicated robotic manipulators. The report includes a preconceptual design of the manipulators, the fuel transfer system, and the used fuel storage system. The present design intent is for used fuel to be stored inside of containment for at least six months and then transferred to local dry wells for intermediate term, on-site storage. The mechanical and structural concept development effort has included an emphasis on transportation and constructability to minimize construction costs and schedule. The design intent is that all components be factory fabricated into rail transportable modules that are assembled into subsystems at an on-site workshop prior to being lifted into position using a heavy-lift crane in an open-top style construction. While detailed accident identification and response sequence analysis has yet to be performed, the design

Letter report: Pre-conceptual design study for a pilot-scale Non-Radioactive Low-Level Waste Vitrification Facility

International Nuclear Information System (INIS)

Thompson, R.A.; Morrissey, M.F.

1996-03-01

This report presents a pre-conceptual design study for a Non-Radioactive Low-Level Waste, Pilot-Scale Vitrification System. This pilot plant would support the development of a full-scale LLW Vitrification Facility and would ensure that the full-scale facility can meet its programmatic objectives. Use of the pilot facility will allow verification of process flowsheets, provide data for ensuring product quality, assist in scaling to full scale, and support full-scale start-up. The facility will vitrify simulated non-radioactive LLW in a manner functionally prototypic to the full-scale facility. This pre-conceptual design study does not fully define the LLW Pilot-Scale Vitrification System; rather, it estimates the funding required to build such a facility. This study includes identifying all equipment necessary. to prepare feed, deliver it into the melter, convert the feed to glass, prepare emissions for atmospheric release, and discharge and handle the glass. The conceived pilot facility includes support services and a structure to contain process equipment

Technical support for GEIS: radioactive waste isolation in geologic formations. Volume 10. Repository preconceptual design studies: granite

International Nuclear Information System (INIS)

1978-04-01

This volume, Volume 10 ''Repository Preconceptual Design Studies: Granite,'' is one of a 23-volume series, ''Technical Support for GEIS: Radioactive Waste Isolation in Geologic Formations,'' Y/OWI/TM-36, which supplements the ''Contribution to Draft Generic Environmental Impact Statement on Commercial Waste Management: Radioactive Waste Isolation in Geologic Formations,'' Y/OWI/TM-44. The series provides a more complete technical basis for the preconceptual designs, resource requirements, and environmental source terms associated with isolating commercial LWR wastes in underground repositories in salt, granite, shale and basalt. Wastes are considered from three fuel cycles: uranium and plutonium recycling, no recycling of spent fuel and uranium-only recycling. This document describes a preconceptual design for a nuclear waste storage facility in granite. The facility design consists of several chambers excavated deep within a geologic formation together with access shafts and supportive surface structures. The facility design provides for: receiving and unloading waste containers; lowering them down shafts to the mine level; transporting them to the proper storage area, and emplacing them in mined storage rooms. Drawings of the facility design are contained in TM-36/11, ''Drawings for Repository Preconceptual Design Studies: Granite.''

Technical support for GEIS: radioactive waste isolation in geologic formations. Volume 8. Repository preconceptual design studies: salt

International Nuclear Information System (INIS)

1978-04-01

This volume, Volume 8 ''Repository Preconceptual Design Studies: Salt,'' is one of a 23-volume series, ''Technical Support for GEIS: Radioactive Waste Isolation in Geologic Formations,'' Y/OWI/TM-36, which supplements the ''Contribution to Draft Generic Environmental Impact Statement on Commercial Waste Management: Radioactive Waste Isolation in Geologic Formations,'' Y/OWI/TM-44. The series provides a more complete technical basis for the preconceptual designs, resource requirements, and environmental source terms associated with isolating commercial LWR wastes in underground repositories in salt, granite, shale and basalt. Wastes are considered from three fuel cycles: uranium and plutonium recycling, no recycling of spent fuel and uranium-only recycling. This document describes a preconceptual design for a nuclear waste storage facility in salt. The facility design consists of several chambers excavated deep within a geologic formation together with access shafts and supportive surface structures. The facility design provides for: receiving and unloading waste containers; lowering them down shafts to the mine level; transporting them to the proper storage area, and emplacing them in mined storage rooms. Drawings of the facility design are contained in TM-36/9, ''Drawings for Repository Preconceptual Design Studies: Salt.''

SECONDARY WASTE/ETF (EFFLUENT TREATMENT FACILITY) PRELIMINARY PRE-CONCEPTUAL ENGINEERING STUDY

International Nuclear Information System (INIS)

May, T.H.; Gehner, P.D.; Stegen, Gary; Hymas, Jay; Pajunen, A.L.; Sexton, Rich; Ramsey, Amy

2009-01-01

This pre-conceptual engineering study is intended to assist in supporting the critical decision (CD) 0 milestone by providing a basis for the justification of mission need (JMN) for the handling and disposal of liquid effluents. The ETF baseline strategy, to accommodate (WTP) requirements, calls for a solidification treatment unit (STU) to be added to the ETF to provide the needed additional processing capability. This STU is to process the ETF evaporator concentrate into a cement-based waste form. The cementitious waste will be cast into blocks for curing, storage, and disposal. Tis pre-conceptual engineering study explores this baseline strategy, in addition to other potential alternatives, for meeting the ETF future mission needs. Within each reviewed case study, a technical and facility description is outlined, along with a preliminary cost analysis and the associated risks and benefits.

Preconceptual engineering design for the APT 3He Target/Blanket concept

International Nuclear Information System (INIS)

Mensink, D.L.

1994-01-01

A preconceptual engineering design has been developed for the 3 He Target/Blanket (T/B) System for the Accelerator Production of Tritium Project. This concept uses an array of pressure tubes containing tungsten rods for the neutron spallation source and 3 He gas contained in a metal tank and blanket tubes as the tritium production material. The engineering design is based on a physics model optimized for efficient tritium production. Principle engineering consideration were: provisions for cooling all materials including the 3 He gas; containment of the gas and radionuclides; remote handling; material compatibility; minimization of 3 He, D 2 O, and activated waste; modularity; and manufacturability. The design provides a basis for estimating the cost to implement the system

Technical support for GEIS: radioactive waste isolation in geologic formations. Volume 12. Repository preconceptual design studies: shale

International Nuclear Information System (INIS)

1978-04-01

This document describes a preconceptual design for a nuclear waste storage facility in shale. The facility design consists of several chambers excavated deep within a geologic formation together with access shafts and supportive surface structures. The facility design provides for: receiving and unloading waste containers; lowering them down shafts to the mine level; transporting them to the proper storage area, and emplacing them in mined storage rooms. Drawings of the facility design are contained in TM-36/13, ''Drawings for Repository Preconceptual Design Studies: Shale.''

Technical support for GEIS: radioactive waste isolation in geologic formations. Volume 14. Repository preconceptual design studies: basalt

International Nuclear Information System (INIS)

1978-04-01

This document describes a preconceptual design for a nuclear waste storage facility in basalt. The facility design consists of several chambers excavated deep within a geologic formation together with access shafts and supportive surface structures. The facility design provides for: receiving and unloading waste containers; lowering them down shafts to the mine level; transporting them to the proper storage area and emplacing them in mined storage rooms. Drawings of the facility design are contained in TM-36/15, ''Drawings for Repository Preconceptual Design Studies: Basalt.''

Pre-conceptual design requirements and system description for FED frame seal welder and cutter

International Nuclear Information System (INIS)

Masson, L.S.; Longhurst, G.R.; Watts, K.D.; Williams, S.A.

1981-03-01

The Fusion Engineering Device (FED) is being designed in a torus shape using ten removable segments to form the torus geometry. The torus consists of a frame and ten shield assemblies which fit into the frame and are held in place structurally using electrically insulated backing plates. It is then necessary to seal the shield segment to the frame for the assembly to sustain an internal vacuum of 10 -7 torr. This task is intended to be accomplished by welding a frame seal between the frame and the shield segment. An example of this concept is shown. This document covers the equipment requirements and pre-conceptual design description for installing and removing the frame seal

Technical support for GEIS: radioactive waste isolation in geologic formations. Volume 16. Repository preconceptual design studies: BPNL waste forms in salt

International Nuclear Information System (INIS)

1978-04-01

This volume, Volume 16, ''Repository Preconceptual Design Studies: BPNL Waste Forms in Salt,'' is one of a 23 volume series, ''Technical Support for GEIS: Radioactive Waste Isolation in Geologic Formations,'' Y/OWI/TM-36, which supplements the ''Contribution to Draft Generic Environmental Impact Statement on Commercial Waste Management: Radioactive Waste Isolation in Geologic Formations,'' Y/OWI/TM-44. The series provide a more complete technical basis for the preconceptual designs, resource requirements, and environmental source terms associated with isolating commercial LWR wastes in underground repositories in salt, granite, shale and basalt. Wastes are considered from three fuel cycles: uranium and plutonium recycling, no recycling of spent fuel and uranium-only recycling. This document describes a preconceptual design for a nuclear waste storage facility in salt. The waste forms assumed to arrive at the repository were supplied by Battelle Pacific Northwest Laboratories (BPNL). The facility design consists of several chambers excavated deep within a geologic formation together with access shafts and supportive surface structures. The facility design provides for: receiving and unloading waste containers; lowering them down shafts to the mine level; transporting them to the proper storage area and emplacing them in mined storage rooms. Drawings of the facility design are contained in TM-36/17, ''Drawings for Repository Preconceptual Design Studies: BPNL Waste Forms in Salt.''

Space Nuclear Power Plant Pre-Conceptual Design Report, For Information

Energy Technology Data Exchange (ETDEWEB)

B. Levine

2006-01-27

This letter transmits, for information, the Project Prometheus Space Nuclear Power Plant (SNPP) Pre-Conceptual Design Report completed by the Naval Reactors Prime Contractor Team (NRPCT). This report documents the work pertaining to the Reactor Module, which includes integration of the space nuclear reactor with the reactor radiation shield, energy conversion, and instrumentation and control segments. This document also describes integration of the Reactor Module with the Heat Rejection segment, the Power Conditioning and Distribution subsystem (which comprise the SNPP), and the remainder of the Prometheus spaceship.

Preconceptual design and assessment of a Tokamak Hybrid Reactor

Energy Technology Data Exchange (ETDEWEB)

Teofilo, V.L.; Leonard, B.R. Jr.; Aase, D.T.

1980-09-01

The preconceptual design of a commercial Tokamak Hybrid Reactor (THR) power plant has been performed. The tokamak fusion driver for this hybrid is operated in the ignition mode. The D-T fusion plasma, which produces 1140 MW of power, has a major radius of 5.4 m and a minor radius of 1.0 m with an elongation of 2.0. Double null poloidal divertors are assumed for impurity control. The confining toroidal field is maintained by D-shaped Nb/sub 3/Sn superconducting magnets with a maximum field of 12T at the coil. Three blankets with four associated fuel cycle alternatives have been combined with the ignited tokamak fusion driver. The engineering, material, and balance of plant design requirements for the THR are briefly described. Estimates of the capital, operating and maintenance, and fuel cycle costs have been made for the various driver/blanket combinations and an assessment of the market penetrability of hybrid systems is presented. An analysis has been made of the nonproliferation aspects of the hybrid and its associated fuel cycles relative to fission reactors. The current and required level of technology for both the fusion and fission components of the hybrid system has been reviewed. Licensing hybrid systems is also considered.

Preconceptual design and assessment of a Tokamak Hybrid Reactor

International Nuclear Information System (INIS)

Teofilo, V.L.; Leonard, B.R. Jr.; Aase, D.T.

1980-09-01

The preconceptual design of a commercial Tokamak Hybrid Reactor (THR) power plant has been performed. The tokamak fusion driver for this hybrid is operated in the ignition mode. The D-T fusion plasma, which produces 1140 MW of power, has a major radius of 5.4 m and a minor radius of 1.0 m with an elongation of 2.0. Double null poloidal divertors are assumed for impurity control. The confining toroidal field is maintained by D-shaped Nb 3 Sn superconducting magnets with a maximum field of 12T at the coil. Three blankets with four associated fuel cycle alternatives have been combined with the ignited tokamak fusion driver. The engineering, material, and balance of plant design requirements for the THR are briefly described. Estimates of the capital, operating and maintenance, and fuel cycle costs have been made for the various driver/blanket combinations and an assessment of the market penetrability of hybrid systems is presented. An analysis has been made of the nonproliferation aspects of the hybrid and its associated fuel cycles relative to fission reactors. The current and required level of technology for both the fusion and fission components of the hybrid system has been reviewed. Licensing hybrid systems is also considered

Pre-conceptual design study on K-DEMO ceramic breeder blanket

Energy Technology Data Exchange (ETDEWEB)

Park, Jong Sung, E-mail: jspark@nfri.re.kr [National Fusion Research Institute, Daejeon 305-333 (Korea, Republic of); Kwon, Sungjin; Im, Kihak; Kim, Keeman [National Fusion Research Institute, Daejeon 305-333 (Korea, Republic of); Brown, Thomas; Neilson, George [Princeton Plasma Physics Laboratory, Princeton, NJ 08543 (United States)

2015-11-15

A pre-conceptual design study has been carried out for the Korean fusion demonstration reactor (K-DEMO) tokamak featured by high magnetic field (B{sub T0} = 7.4 T), R = 6.8 m, a = 2.1 m, and a steady-state operation. The design concepts of the K-DEMO blanket system considering the cooling in-vessel components with pressurized water and a solid pebble breeder are described herein. The structure of the K-DEMO blanket is toroidally subdivided into 16 inboard and 32 outboard sectors, in order to allow the vertical maintenance. Each blanket module is composed of plasma-facing first wall, layers of breeding parts, shielding and manifolds. A ceramic breeder using Li{sub 4}SiO{sub 4} pebbles with Be{sub 12}Ti as neuron multiplier is employed for study. MCNP neutronic simulations and thermo-hydraulic analyses are interactively performed in order to satisfy two key aspects: achieving a global Tritium Breeding Ratio (TBR) >1.05 and operating within the maximum allowable temperature ranges of materials.

Supplemental technical information in support of Y/OWI/TM--44. Volume 15. Drawings for repository preconceptual design studies: basalt

International Nuclear Information System (INIS)

1978-04-01

Volume 15 contains the drawings of a preconceptual design for a nuclear waste repository in basalt. Three fuel cycles are considered: fuel recycle, throwaway cycle, and uranium recycle with plutonium in the high-level wastes

Supplemental technical information in support of Y/OWI/TM--44. Volume 9. Drawings for repository preconceptual design studies: salt

International Nuclear Information System (INIS)

1978-04-01

Volume 9 contains drawings for a preconceptual design for a nuclear waste storage facility in salt. Drawings are included for three fuel cycles: fuel recycle, throwaway fuel cycle, and uranium recycle with plutonium in the high-level waste

Final Technical Report for the Period September 2002 through September 2005; H2-MHR Pre-Conceptual Design Report: SI-Based Plant; H2-MHR Pre-Conceptual Design Report: HTE-Based Plant

Energy Technology Data Exchange (ETDEWEB)

M. Richards; A. Shenoy; L. Brown; R. Buckingham; E. Harvego; K. Peddicord; M. Reza; J. Coupey

2006-04-19

For electricity and hydrogen production, an advanced reactor technology receiving considerable international interest is a modular, passively-safe version of the high-temperature, gas-cooled reactor, known in the U.S. as the Modular Helium Reactor (MHR), which operates at a power level of 600 MW(t). For electricity production, the MHR operates with an outlet helium temperature of 850 C to drive a direct, Brayton-cycle power-conversion system with a thermal-to-electrical conversion efficiency of 48 percent. This concept is referred to as the Gas Turbine MHR (GT-MHR). For hydrogen production, both electricity and process heat from the MHR are used to produce hydrogen. This concept is referred to as the H2-MHR. This report provides pre-conceptual design descriptions of full-scale, nth-of-a-kind H2 MHR plants based on thermochemical water splitting using the Sulfur-Iodine process and High-Temperature Electrolysis.

Preconceptual design of a Long-Pulse Spallation Source (LPSS) at the LANSCE Facility: Target system, facility, and material handling considerations

International Nuclear Information System (INIS)

Sommer, W.F.

1995-12-01

This report provides a summary of a preconceptual design study for the proposed Long-Pulse Spallation. Source (LPSS) at the Los Alamos Neutron Science Center (LANSCE). The LPSS will use a 0.8-MW proton beam to produce neutrons from a tungsten target. This study focuses on the design of the target station and changes to the existing building that would be made to accommodate the LPSS. The LPSS will provide fifteen flight paths to neutron scattering instruments. In addition, options for generating ultracold neutrons, pions, and muons will be available. Flight-energy, forward-scattered neutrons on the downstream side of the target will also be available for autoradiography studies. A Target Test Bed (TTB) is also proposed for full-beam tests of component materials and advanced spallation neutron sources. The design allows for separation of the experiment hall from the beam line, target, and flight paths. The target and moderator systems and the systems/components to be tested in the TTB will be emplaced and removed separately by remotely operated, shielded equipment. Irradiated materials will be transported to a hot cell adjacent to the target chamber for testing by remotely operated instruments. These tests will provide information about how materials properties are affected by proton and neutron beams

Supplemental technical information in support of Y/OWI/TM--44. Volume 17. Drawings for repository preconceptual design studies: BPNL waste forms in salt

International Nuclear Information System (INIS)

1978-04-01

Volume 17 contains drawings of a preconceptual design for a nuclear waste storage facility in salt. Three full cycles are considered: full recycle, throwaway cycle, and uranium recycle with plutonium in high-level waste

Preconceptual design study for solidifying high-level waste: West Valley Demonstration Project

International Nuclear Information System (INIS)

1981-04-01

This Appendix contains the preconceptual design drawings prepared by Vitro Engineering Corporation for Pacific Northwest Laboratory. The following types of drawings are included in this Appendix: process flow diagrams; process and instrumentation diagrams; hydraulic diagrams; equipment arrangement drawings; service gallery drawings; electric power one-line diagram; equipment line lists; and outline specifications. The basic purpose of these drawings was to determine the feasibility of installing the reference solidification process in existing cells at the Western New York Nuclear Service Center. Most of the process and vitrification equipment will be installed in the former Chemical Processing Cell, while the salt solidification equipment will be housed in the former Scrap Removal Room. The design utilized a remote maintenance and operation concept

Preconceptual design of the gas-phase decontamination demonstration cart

International Nuclear Information System (INIS)

Munday, E.B.

1993-12-01

Removal of uranium deposits from the interior surfaces of gaseous diffusion equipment will be a major portion of the overall multibillion dollar effort to decontaminate and decommission the gaseous diffusion plants. Long-term low-temperature (LTLT) gas-phase decontamination is being developed at the K-25 Site as an in situ decontamination process that is expected to significantly lower the decontamination costs, reduce worker exposure to radioactive materials, and reduce safeguard concerns. This report documents the preconceptual design of the process equipment that is necessary to conduct a full-scale demonstration of the LTLT method in accordance with the process steps listed above. The process equipment and method proposed in this report are not intended to represent a full-scale production campaign design and operation, since the gas evacuation, gas charging, and off-gas handling systems that would be cost effective in a production campaign are not cost effective for a first-time demonstration. However, the design presented here is expected to be applicable to special decontamination projects beyond the demonstration, which could include the Deposit Recovery Program. The equipment will therefore be sized to a 200 ft size 1 converter (plus a substantial conservative design margin), which is the largest item of interest for gas phase decontamination in the Deposit Recovery Program. The decontamination equipment will allow recovery of the UF 6 , which is generated from the reaction of ClF 3 with the uranium deposits, by use of NaF traps

High-level waste solidification system for the Western New York Nuclear Service Center

International Nuclear Information System (INIS)

Carrell, J.R.; Holton, L.K.; Siemens, D.H.

1982-01-01

A preconceptual design for a waste conditioning and solidification system for the immobilization of the high-level liquid wastes (HLLW) stored at the Western New York Nuclear Service Center (WNYNSC), West Valley, New York was completed in 1981. The preconceptual design was conducted as part of the Department of Energy's (DOE) West Valley Demonstration Project, which requires a waste management demonstration at the WNYNSC. This paper summarizes the bases, assumptions, results and conclusions of the preconceptual design study

Preliminary geochemical and physical testing of materials for plugging of man-made accesses to a repository in basalt

International Nuclear Information System (INIS)

Taylor, C.L.; Anttonen, G.J.; O'Rourke, J.E.; Allirot, D.

1980-04-01

The available data on environmental conditions (both natural and man-made) at the Hanford Site are sufficient for preconceptual plug system design. Results of the geochemical testing program indicate that preferred candidate plug materials are chemically nonreactive during laboratory tests that simulated some of the expected environmental conditions. Agitated, crushed-basalt samples and mixtures containing basalt were found to be self-cementing under the hydrothermal conditions. Materials considered most suitable for consideration in future test programs and preconceptual plug design are mixtures of natural materials (basalt, clay, glaciofluvial sand, gravel, and zeolite) and processed natural materials

Status of the Astrid core at the end of the pre-conceptual design phase 1

International Nuclear Information System (INIS)

Chenaud, Ms.; Devictor, N.; Mignot, G.; Varaine, F.; Venard, C.; Martin, L.; Phelip, M.; Lorenzo, D.; Serre, F.; Bertrand, F.; Alpy, N.; Le-Flem, M.; Gavoille, P.; Lavastre, R.; Richard, P.; Verrier, D.; Schmitt, D.

2013-01-01

Within the framework of the ASTRID project, core design studies are being conducted by the CEA with support from AREVA and EDF. The pre-conceptual design studies are being conducted in accordance with the GEN IV reactor objectives, particularly in terms of improving safety. This involves limiting the consequences of 1) a hypothetical control rod withdrawal accident (by minimizing the core reactivity loss during the irradiation cycle), and 2) an hypothetical loss-of-flow accident (by reducing the sodium void worth). Two types of cores are being studied for the ASTRID project. The first is based on a 'large pin/small spacing wire' concept derived from the SFR V2b, while the other is based on an innovative CFV design. A distinctive feature of the CFV core is its negative sodium void worth. In 2011, the evaluation of a preliminary version (v1) of this CFV core for ASTRID underlined its potential capacity to improve the prevention of severe accidents. An improved version of the ASTRID CFV core (v2) was proposed in 2012 to comply with all the control rod withdrawal criteria, while increasing safety margins for all unprotected-loss-of-flow (ULOF) transients and improving the general design. This paper describes the CFV v2 design options and reports on the progress of the studies at the end of pre-conceptual design phase 1 concerning: - Core performance, - Intrinsic behavior during unprotected transients, - Simulation of severe accident scenarios, - Qualification requirements. The paper also specifies the open options for the materials, sub-assemblies, absorbers, and core monitoring that will continue to be studied during the conceptual design phase. (authors)

Reactor Physics Methods and Preconceptual Core Design Analyses for Conversion of the Advanced Test Reactor to Low-Enriched Uranium Fuel Annual Report for Fiscal Year 2012

Energy Technology Data Exchange (ETDEWEB)

David W. Nigg; Sean R. Morrell

2012-09-01

Under the current long-term DOE policy and planning scenario, both the ATR and the ATRC will be reconfigured at an appropriate time within the next several years to operate with low-enriched uranium (LEU) fuel. This will be accomplished under the auspices of the Reduced Enrichment Research and Test Reactor (RERTR) Program, administered by the DOE National Nuclear Security Administration (NNSA). At a minimum, the internal design and composition of the fuel element plates and support structure will change, to accommodate the need for low enrichment in a manner that maintains total core excess reactivity at a suitable level for anticipated operational needs throughout each cycle while respecting all control and shutdown margin requirements and power distribution limits. The complete engineering design and optimization of LEU cores for the ATR and the ATRC will require significant multi-year efforts in the areas of fuel design, development and testing, as well as a complete re-analysis of the relevant reactor physics parameters for a core composed of LEU fuel, with possible control system modifications. Ultimately, revalidation of the computational physics parameters per applicable national and international standards against data from experimental measurements for prototypes of the new ATR and ATRC core designs will also be required for Safety Analysis Report (SAR) changes to support routine operations with LEU. This report is focused on reactor physics analyses conducted during Fiscal Year (FY) 2012 to support the initial development of several potential preconceptual fuel element designs that are suitable candidates for further study and refinement during FY-2013 and beyond. In a separate, but related, effort in the general area of computational support for ATR operations, the Idaho National Laboratory (INL) is conducting a focused multiyear effort to introduce modern high-fidelity computational reactor physics software and associated validation protocols to replace

AHTR Mechanical, Structural, And Neutronic Preconceptual Design

Energy Technology Data Exchange (ETDEWEB)

Varma, Venugopal Koikal [ORNL; Holcomb, David Eugene [ORNL; Peretz, Fred J [ORNL; Bradley, Eric Craig [ORNL; Ilas, Dan [ORNL; Qualls, A L [ORNL; Zaharia, Nathaniel M [ORNL

2012-10-01

base isolation, and 4) decay heat powered back-up electricity generation. The report provides a preconceptual design of the manipulators, the fuel transfer system, and the salt transfer loops. The mechanical handling of the fuel and how it is accomplished without instrumentation inside the salt is described within the report. All drives for the manipulators reside outside the reactor top flange. The design has also taken into account the transportability of major components and how they will be assembled on site

Pre-conceptual design assessment of DEMO remote maintenance

Energy Technology Data Exchange (ETDEWEB)

Loving, A., E-mail: antony.loving@ccfe.ac.uk [EURATOM/Culham Center Fusion Energy, Culham Science Centre, OX14 3DB, Abingdon (United Kingdom); Crofts, O.; Sykes, N.; Iglesias, D.; Coleman, M.; Thomas, J. [EURATOM/Culham Center Fusion Energy, Culham Science Centre, OX14 3DB, Abingdon (United Kingdom); Harman, J. [EFDA Close Support Unit Garching, Boltzmannstaße 2, D-85748 Garching Bei München (Germany); Fischer, U. [Karlsruhe Institute of Technology, Institute for Neutron Physics and Reactor Technology, Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen (Germany); Sanz, J. [Instituto de Fusión Nuclear/UPM, Madrid (Spain); Siuko, M. [VTT Technical Research Centre of Finland, P.O. Box 1000, FI-02044 VTT (Finland); Mittwollen, M. [Karlsruhe Institute of Technology, Institut für Fördertechnik und Logistiksysteme, Gotthard-Franz-Straße 8, Geb.50.38, 76131 Karlsruhe (Germany)

2014-10-15

EDFA, as part of the Power Plant Physics and Technology programme, has been working on the pre-conceptual design of a Demonstration Power Plant (DEMO). As part of this programme, a review of the remote maintenance strategy considered maintenance solutions compatible with expected environmental conditions, whilst showing potential for meeting the plant availability targets. A key finding was that, for practical purposes, the expected radiation levels prohibit the use of complex remote handling operations to replace the first wall. In 2012/2013, these remote maintenance activities were further extended, providing an insight into the requirements, constraints and challenges. In particular, the assessment of blanket and divertor maintenance, in light of the expected radiation conditions and availability, has elaborated the need for a very different approach from that of ITER. This activity has produced some very informative virtual reality simulations of the blanket segments and pipe removal that are exceptionally valuable in communicating the complexity and scale of the required operations. Through these simulations, estimates of the maintenance task durations have been possible demonstrating that a full replacement of the blankets within 6 months could be achieved. The design of the first wall, including the need to use sacrificial limiters must still be investigated. In support of the maintenance operations, a first indication of the requirements of an Active Maintenance Facility (AMF) has been elaborated.

Preliminary geochemical and physical testing of materials for plugging of man-made accesses to a repository in basalt

Energy Technology Data Exchange (ETDEWEB)

Taylor, C.L.; Anttonen, G.J.; O' Rourke, J.E.; Allirot, D.

1980-04-01

The available data on environmental conditions (both natural and man-made) at the Hanford Site are sufficient for preconceptual plug system design. Results of the geochemical testing program indicate that preferred candidate plug materials are chemically nonreactive during laboratory tests that simulated some of the expected environmental conditions. Agitated, crushed-basalt samples and mixtures containing basalt were found to be self-cementing under the hydrothermal conditions. Materials considered most suitable for consideration in future test programs and preconceptual plug design are mixtures of natural materials (basalt, clay, glaciofluvial sand, gravel, and zeolite) and processed natural materials (portland cement Type V and grouts plus additives).

ARCHITECTURE AND DYNAMICS OF KEPLER'S CANDIDATE MULTIPLE TRANSITING PLANET SYSTEMS

Energy Technology Data Exchange (ETDEWEB)

Lissauer, Jack J.; Jenkins, Jon M.; Borucki, William J.; Bryson, Stephen T.; Howell, Steve B. [NASA Ames Research Center, Moffett Field, CA 94035 (United States); Ragozzine, Darin; Holman, Matthew J.; Carter, Joshua A. [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States); Fabrycky, Daniel C.; Fortney, Jonathan J. [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); Steffen, Jason H. [Fermilab Center for Particle Astrophysics, Batavia, IL 60510 (United States); Ford, Eric B. [211 Bryant Space Science Center, University of Florida, Gainesville, FL 32611 (United States); Shporer, Avi [Las Cumbres Observatory Global Telescope Network, Santa Barbara, CA 93117 (United States); Rowe, Jason F.; Quintana, Elisa V.; Caldwell, Douglas A. [SETI Institute/NASA Ames Research Center, Moffett Field, CA 94035 (United States); Batalha, Natalie M. [Department of Physics and Astronomy, San Jose State University, San Jose, CA 95192 (United States); Ciardi, David [Exoplanet Science Institute/Caltech, Pasadena, CA 91125 (United States); Dunham, Edward W. [Lowell Observatory, Flagstaff, AZ 86001 (United States); Gautier, Thomas N. III, E-mail: Jack.Lissauer@nasa.gov [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109 (United States); and others

2011-11-01

About one-third of the {approx}1200 transiting planet candidates detected in the first four months of Kepler data are members of multiple candidate systems. There are 115 target stars with two candidate transiting planets, 45 with three, 8 with four, and 1 each with five and six. We characterize the dynamical properties of these candidate multi-planet systems. The distribution of observed period ratios shows that the vast majority of candidate pairs are neither in nor near low-order mean-motion resonances. Nonetheless, there are small but statistically significant excesses of candidate pairs both in resonance and spaced slightly too far apart to be in resonance, particularly near the 2:1 resonance. We find that virtually all candidate systems are stable, as tested by numerical integrations that assume a nominal mass-radius relationship. Several considerations strongly suggest that the vast majority of these multi-candidate systems are true planetary systems. Using the observed multiplicity frequencies, we find that a single population of planetary systems that matches the higher multiplicities underpredicts the number of singly transiting systems. We provide constraints on the true multiplicity and mutual inclination distribution of the multi-candidate systems, revealing a population of systems with multiple super-Earth-size and Neptune-size planets with low to moderate mutual inclinations.

Preconceptual design and analysis of a solid-breeder blanket test in an existing fission reactor

International Nuclear Information System (INIS)

Deis, G.A.; Hsu, P.Y.; Watts, K.D.

1983-01-01

Preconceptual design and analysis have been performed to examine the capabilities of a proposed fission-based test of a water-cooled Li 2 O blanket concept. The mechanical configuration of the test piece is designed to simulate a unit cell of a breeder-outside-tube concept. This test piece will be placed in a fission test reactor, which provides an environment similar to that in a fusion reactor. The neutron/gamma flux from the reactor produces prototypical power density, tritium production rates, and operating temperatures and stresses. Steady-state tritium recovery from the test piece can be attained in short-duration (5-to-6-day) tests. The capabilities of this test indicate that fission-based testing can provide important near-term engineering information to support the development of fusion technology

Preconceptual design study for solidifying high-level waste: West Valley Demonstration Project

International Nuclear Information System (INIS)

Hill, O.F.

1981-04-01

This report presents a preconceptual design study for processing radioactive high-level liquid waste presently stored in underground tanks at Western New York Nuclear Service Center (WNYNSC) near West Valley, New York, and for incorporating the radionculides in that waste into a solid. The high-level liquid waste accumulated from the operation of a chemical reprocessing plant by the Nuclear Fuel Services, Inc. from 1966 to 1972. The high-level liquid waste consists of approximately 560,000 gallons of alkaline waste from Purex process operations and 12,000 gallons of acidic (nitric acid) waste from one campaign of processing thoria fuels by a modified Thorex process (during this campaign thorium was left in the waste). The alkaline waste contains approximately 30 million curies and the acidic waste contains approximately 2.5 million curies. The reference process described in this report is concerned only with chemically processing the high-level liquid waste to remove radionuclides from the alkaline supernate and converting the radionuclide-containing nonsalt components in the waste into a borosilicate glass

Technical support for GEIS: radioactive waste isolation in geologic formations. Volume 2. Commercial waste forms, packaging and projections for preconceptual repository design studies

International Nuclear Information System (INIS)

1978-04-01

This volume, Y/OWI/TM-36/2, ''Commercial Waste Forms, Packaging and Projections for Preconceptual Repository Design Studies,'' is one of a 23-volume series, ''Technical Support for GEIS: Radioactive Waste Isolation in Geologic Formations,'' Y/OWI/TM-36, which supplements the ''Contribution to Draft Generic Environmental Impact Statement on Commercial Waste Management: Radioactive Waste Isolation in Geologic Formations,'' Y/OWI/TM-44. The series provides a more complete technical basis for the preconceptual designs, resource requirements, and environmental source terms associated with isolating commercial LWR wastes in underground repositories in salt, granite, shale and basalt. Wastes are considered from three fuel cycles: uranium and plutonium recycling, no recycling of spent fuel and uranium-only recycling. This volume contains the data base for waste forms, packages, and projections from the commercial waste defined by the Office of Waste Isolation in ''Nuclear Waste Projections and Source Term Data for FY 1977,'' Y/OWI/TM-34. Also, as an alternative data base for repository design and analysis, waste forms, packages, and projections for commercial waste defined by Battelle Pacific Northwest Laboratory (BPNL) have been included. This data base consists of a reference case for use in the alternative design study and a definition of combustible wastes for use in mine fire and hydrogen generation analyses

Integrated thermal treatment system study: Phase 1 results. Volume 1

International Nuclear Information System (INIS)

Feizollahi, F.; Quapp, W.J.; Hempill, H.G.; Groffie, F.J.

1994-07-01

An integrated systems engineering approach is used for uniform comparison of widely varying thermal treatment technologies proposed for management of contact-handled mixed low-level waste (MLLW) currently stored in the US Department of Energy complex. Ten different systems encompassing several incineration design options are studied. All subsystems, including facilities, equipment, and methods needed for integration of each of the ten systems are identified. Typical subsystems needed for complete treatment of MLLW are incoming waste receiving and preparation (characterization, sorting, sizing, and separation), thermal treatment, air pollution control, primary and secondary stabilization, metal decontamination, metal melting, mercury recovery, lead recovery, and special waste and aqueous waste treatment. The evaluation is performed by developing a preconceptual design package and planning life-cycle cost (PLCC) estimates for each system. As part of the preconceptual design process, functional and operational requirements, flow sheets and mass balances, and conceptual equipment layouts are developed for each system. The PLCC components estimated are technology development, production facility construction, pre-operation, operation and maintenance, and decontamination and decommissioning. Preconceptual design data and other technology information gathered during the study are examined and areas requiring further development, testing, and evaluation are identified and recommended. Using a qualitative method, each of the ten systems are ranked

A FIRST COMPARISON OF KEPLER PLANET CANDIDATES IN SINGLE AND MULTIPLE SYSTEMS

International Nuclear Information System (INIS)

Latham, David W.; Quinn, Samuel N.; Carter, Joshua A.; Holman, Matthew J.; Rowe, Jason F.; Borucki, William J.; Bryson, Stephen T.; Howell, Steve B.; Batalha, Natalie M.; Brown, Timothy M.; Buchhave, Lars A.; Caldwell, Douglas A.; Christiansen, Jessie L.; Ciardi, David R.; Cochran, William D.; Dunham, Edward W.; Fabrycky, Daniel C.; Ford, Eric B.; Gautier, Thomas N. III; Gilliland, Ronald L.

2011-01-01

In this Letter, we present an overview of the rich population of systems with multiple candidate transiting planets found in the first four months of Kepler data. The census of multiples includes 115 targets that show two candidate planets, 45 with three, eight with four, and one each with five and six, for a total of 170 systems with 408 candidates. When compared to the 827 systems with only one candidate, the multiples account for 17% of the total number of systems, and one-third of all the planet candidates. We compare the characteristics of candidates found in multiples with those found in singles. False positives due to eclipsing binaries are much less common for the multiples, as expected. Singles and multiples are both dominated by planets smaller than Neptune; 69 +2 -3 % for singles and 86 +2 -5 % for multiples. This result, that systems with multiple transiting planets are less likely to include a transiting giant planet, suggests that close-in giant planets tend to disrupt the orbital inclinations of small planets in flat systems, or maybe even prevent the formation of such systems in the first place.

Technical support for GEIS: radioactive waste isolation in geologic formations. Volume 2. Commercial waste forms, packaging and projections for preconceptual repository design studies

Energy Technology Data Exchange (ETDEWEB)

1978-04-01

This volume, Y/OWI/TM-36/2, ''Commercial Waste Forms, Packaging and Projections for Preconceptual Repository Design Studies,'' is one of a 23-volume series, ''Technical Support for GEIS: Radioactive Waste Isolation in Geologic Formations,'' Y/OWI/TM-36, which supplements the ''Contribution to Draft Generic Environmental Impact Statement on Commercial Waste Management: Radioactive Waste Isolation in Geologic Formations,'' Y/OWI/TM-44. The series provides a more complete technical basis for the preconceptual designs, resource requirements, and environmental source terms associated with isolating commercial LWR wastes in underground repositories in salt, granite, shale and basalt. Wastes are considered from three fuel cycles: uranium and plutonium recycling, no recycling of spent fuel and uranium-only recycling. This volume contains the data base for waste forms, packages, and projections from the commercial waste defined by the Office of Waste Isolation in ''Nuclear Waste Projections and Source Term Data for FY 1977,'' Y/OWI/TM-34. Also, as an alternative data base for repository design and analysis, waste forms, packages, and projections for commercial waste defined by Battelle Pacific Northwest Laboratory (BPNL) have been included. This data base consists of a reference case for use in the alternative design study and a definition of combustible wastes for use in mine fire and hydrogen generation analyses.

Advanced burner test reactor preconceptual design report.

Energy Technology Data Exchange (ETDEWEB)

Chang, Y. I.; Finck, P. J.; Grandy, C.; Cahalan, J.; Deitrich, L.; Dunn, F.; Fallin, D.; Farmer, M.; Fanning, T.; Kim, T.; Krajtl, L.; Lomperski, S.; Moisseytsev, A.; Momozaki, Y.; Sienicki, J.; Park, Y.; Tang, Y.; Reed, C.; Tzanos, C; Wiedmeyer, S.; Yang, W.; Chikazawa, Y.; JAEA

2008-12-16

advanced fuel cycle; (2) To qualify the transuranics-containing fuels and advanced structural materials needed for a full-scale ABR; and (3) To support the research, development and demonstration required for certification of an ABR standard design by the U.S. Nuclear Regulatory Commission. The ABTR should also address the following additional objectives: (1) To incorporate and demonstrate innovative design concepts and features that may lead to significant improvements in cost, safety, efficiency, reliability, or other favorable characteristics that could promote public acceptance and future private sector investment in ABRs; (2) To demonstrate improved technologies for safeguards and security; and (3) To support development of the U.S. infrastructure for design, fabrication and construction, testing and deployment of systems, structures and components for the ABRs. Based on these objectives, a pre-conceptual design of a 250 MWt ABTR has been developed; it is documented in this report. In addition to meeting the primary and additional objectives listed above, the lessons learned from fast reactor programs in the U.S. and worldwide and the operating experience of more than a dozen fast reactors around the world, in particular the Experimental Breeder Reactor-II have been incorporated into the design of the ABTR to the extent possible.

Candidal Arthritis After Complete Treatment of Systemic Candidiasis

Directory of Open Access Journals (Sweden)

Wen-Bin Hsieh

2005-04-01

Full Text Available Over the last few decades, the incidence of invasive candidal infections in neonatal intensive care units has increased dramatically. Various complications, such as arthritis, endocarditis, meningitis, and endophthalmitis, have been reviewed. We present the case of a premature infant with systemic candidemia. Arthritis was discovered 6 months after completion of amphotericin B therapy, and was successfully treated with oral fluconazole for 6 weeks. We conclude that long-term follow-up is particularly important in patients with treated candidemia. To prevent complications, prolonged treatment with high-dose amphotericin B is suggested for systemic fungal infection, and oral fluconazole is an effective alternative for candidal arthritis.

Status of Preconceptual Design of the Advanced High-Temperature Reactor (AHTR)

Energy Technology Data Exchange (ETDEWEB)

Ingersoll, D.T.

2004-07-29

A new reactor plant concept is presented that combines the benefits of ceramic-coated, high-temperature particle fuel with those of clean, high-temperature, low-pressure molten salt coolant. The Advanced High-Temperature Reactor (AHTR) concept is a collaboration of Oak Ridge National Laboratory, Sandia National Laboratories, and the University of California at Berkeley. The purpose of the concept is to provide an advanced design capable of satisfying the top-level functional requirements of the U.S. Department of Energy Next Generation Nuclear Plant (NGNP), while also providing a technology base that is sufficiently robust to allow future development paths to higher temperatures and larger outputs with highly competitive economics. This report summarizes the status of the AHTR preconceptual design. It captures the results from an intense effort over a period of 3 months to (1) screen and examine potential feasibility concerns with the concept; (2) refine the conceptual design of major systems; and (3) identify research, development, and technology requirements to fully mature the AHTR design. Several analyses were performed and are presented to quantify the AHTR performance expectations and to assist in the selection of several design parameters. The AHTR, like other NGNP reactor concepts, uses coated particle fuel in a graphite matrix. But unlike the other NGNP concepts, the AHTR uses molten salt rather than helium as the primary system coolant. The considerable previous experience with molten salts in nuclear environments is discussed, and the status of high-temperature materials is reviewed. The large thermal inertia of the system, the excellent heat transfer and fission product retention characteristics of molten salt, and the low-pressure operation of the primary system provide significant safety attributes for the AHTR. Compared with helium coolant, a molten salt cooled reactor will have significantly lower fuel temperatures (150-200-C lower) for the

Status of Preconceptual Design of the Advanced High-Temperature Reactor (AHTR)

International Nuclear Information System (INIS)

Ingersoll, D.T.

2004-01-01

A new reactor plant concept is presented that combines the benefits of ceramic-coated, high-temperature particle fuel with those of clean, high-temperature, low-pressure molten salt coolant. The Advanced High-Temperature Reactor (AHTR) concept is a collaboration of Oak Ridge National Laboratory, Sandia National Laboratories, and the University of California at Berkeley. The purpose of the concept is to provide an advanced design capable of satisfying the top-level functional requirements of the U.S. Department of Energy Next Generation Nuclear Plant (NGNP), while also providing a technology base that is sufficiently robust to allow future development paths to higher temperatures and larger outputs with highly competitive economics. This report summarizes the status of the AHTR preconceptual design. It captures the results from an intense effort over a period of 3 months to (1) screen and examine potential feasibility concerns with the concept; (2) refine the conceptual design of major systems; and (3) identify research, development, and technology requirements to fully mature the AHTR design. Several analyses were performed and are presented to quantify the AHTR performance expectations and to assist in the selection of several design parameters. The AHTR, like other NGNP reactor concepts, uses coated particle fuel in a graphite matrix. But unlike the other NGNP concepts, the AHTR uses molten salt rather than helium as the primary system coolant. The considerable previous experience with molten salts in nuclear environments is discussed, and the status of high-temperature materials is reviewed. The large thermal inertia of the system, the excellent heat transfer and fission product retention characteristics of molten salt, and the low-pressure operation of the primary system provide significant safety attributes for the AHTR. Compared with helium coolant, a molten salt cooled reactor will have significantly lower fuel temperatures (150-200-C lower) for the

A preliminary systems assessment of the Starlite Demo candidates

International Nuclear Information System (INIS)

Bathke, C.G.

1995-01-01

The Starlite project has evaluated the following five tokamaks as candidates for the US Demo Power Plant: (1) steady state, first stability regime; (2) pulsed, first stability regime; (3) steady state, second stability regime; (4) steady state, reversed shear; and (5) steady state, low aspect ratio. Systems analysis of these candidates has played an important role in the selection of a reversed-shear tokamak for further conceptual design as a US Demo Power Plant. The cost-based systems analysis that led to the selection of a reversed-shear tokamak is described herein

Preconceptual design of a salt splitting process using ceramic membranes

Energy Technology Data Exchange (ETDEWEB)

Kurath, D.E.; Brooks, K.P.; Hollenberg, G.W.; Clemmer, R. [Pacific Northwest National Lab., Richland, WA (United States); Balagopal, S.; Landro, T.; Sutija, D.P. [Ceramatec, Inc., Salt Lake City, UT (United States)

1997-01-01

Inorganic ceramic membranes for salt splitting of radioactively contaminated sodium salt solutions are being developed for treating U. S. Department of Energy tank wastes. The process consists of electrochemical separation of sodium ions from the salt solution using sodium (Na) Super Ion Conductors (NaSICON) membranes. The primary NaSICON compositions being investigated are based on rare- earth ions (RE-NaSICON). Potential applications include: caustic recycling for sludge leaching, regenerating ion exchange resins, inhibiting corrosion in carbon-steel tanks, or retrieving tank wastes; reducing the volume of low-level wastes volume to be disposed of; adjusting pH and reducing competing cations to enhance cesium ion exchange processes; reducing sodium in high-level-waste sludges; and removing sodium from acidic wastes to facilitate calcining. These applications encompass wastes stored at the Hanford, Savannah River, and Idaho National Engineering Laboratory sites. The overall project objective is to supply a salt splitting process unit that impacts the waste treatment and disposal flowsheets and meets user requirements. The potential flowsheet impacts include improving the efficiency of the waste pretreatment processes, reducing volume, and increasing the quality of the final waste disposal forms. Meeting user requirements implies developing the technology to the point where it is available as standard equipment with predictable and reliable performance. This report presents two preconceptual designs for a full-scale salt splitting process based on the RE-NaSICON membranes to distinguish critical items for testing and to provide a vision that site users can evaluate.

Preconceptual design of a salt splitting process using ceramic membranes

International Nuclear Information System (INIS)

Kurath, D.E.; Brooks, K.P.; Hollenberg, G.W.; Clemmer, R.; Balagopal, S.; Landro, T.; Sutija, D.P.

1997-01-01

Inorganic ceramic membranes for salt splitting of radioactively contaminated sodium salt solutions are being developed for treating U. S. Department of Energy tank wastes. The process consists of electrochemical separation of sodium ions from the salt solution using sodium (Na) Super Ion Conductors (NaSICON) membranes. The primary NaSICON compositions being investigated are based on rare- earth ions (RE-NaSICON). Potential applications include: caustic recycling for sludge leaching, regenerating ion exchange resins, inhibiting corrosion in carbon-steel tanks, or retrieving tank wastes; reducing the volume of low-level wastes volume to be disposed of; adjusting pH and reducing competing cations to enhance cesium ion exchange processes; reducing sodium in high-level-waste sludges; and removing sodium from acidic wastes to facilitate calcining. These applications encompass wastes stored at the Hanford, Savannah River, and Idaho National Engineering Laboratory sites. The overall project objective is to supply a salt splitting process unit that impacts the waste treatment and disposal flowsheets and meets user requirements. The potential flowsheet impacts include improving the efficiency of the waste pretreatment processes, reducing volume, and increasing the quality of the final waste disposal forms. Meeting user requirements implies developing the technology to the point where it is available as standard equipment with predictable and reliable performance. This report presents two preconceptual designs for a full-scale salt splitting process based on the RE-NaSICON membranes to distinguish critical items for testing and to provide a vision that site users can evaluate

Preconceptual ABC design definition and system configuration layout

International Nuclear Information System (INIS)

Barthold, W.

1995-03-01

This document is the conceptual design document for the follow-on to the Molten Salt Breeder Reactor, known as the ABC type reactor. It addresses blanket design options, containment options, off-gas systems, drainage systems, and components/layouts of the primary, secondary, and tertiary systems, and it contains a number of diagrams for the configuration of the major systems

Robo-AO Kepler Survey. IV. The Effect of Nearby Stars on 3857 Planetary Candidate Systems

Science.gov (United States)

Ziegler, Carl; Law, Nicholas M.; Baranec, Christoph; Riddle, Reed; Duev, Dmitry A.; Howard, Ward; Jensen-Clem, Rebecca; Kulkarni, S. R.; Morton, Tim; Salama, Maïssa

2018-04-01

We present the overall statistical results from the Robo-AO Kepler planetary candidate survey, comprising of 3857 high-angular resolution observations of planetary candidate systems with Robo-AO, an automated laser adaptive optics system. These observations reveal previously unknown nearby stars blended with the planetary candidate host stars that alter the derived planetary radii or may be the source of an astrophysical false positive transit signal. In the first three papers in the survey, we detected 440 nearby stars around 3313 planetary candidate host stars. In this paper, we present observations of 532 planetary candidate host stars, detecting 94 companions around 88 stars; 84 of these companions have not previously been observed in high resolution. We also report 50 more-widely separated companions near 715 targets previously observed by Robo-AO. We derive corrected planetary radius estimates for the 814 planetary candidates in systems with a detected nearby star. If planetary candidates are equally likely to orbit the primary or secondary star, the radius estimates for planetary candidates in systems with likely bound nearby stars increase by a factor of 1.54, on average. We find that 35 previously believed rocky planet candidates are likely not rocky due to the presence of nearby stars. From the combined data sets from the complete Robo-AO KOI survey, we find that 14.5 ± 0.5% of planetary candidate hosts have a nearby star with 4″, while 1.2% have two nearby stars, and 0.08% have three. We find that 16% of Earth-sized, 13% of Neptune-sized, 14% of Saturn-sized, and 19% of Jupiter-sized planet candidates have detected nearby stars.

Pre-conceptual core design of a small modular fast reactor cooled by supercritical CO{sub 2}

Energy Technology Data Exchange (ETDEWEB)

Liu, Baolin; Cao, Liangzhi; Wu, Hongchun [School of Nuclear Science and Technology, Xi’an Jiaotong University, No 28, Xianning West Road, Xi’an 710049, Shaanxi (China); Yuan, Xianbao, E-mail: ztsbaby@163.com [School of Nuclear Science and Technology, Xi’an Jiaotong University, No 28, Xianning West Road, Xi’an 710049, Shaanxi (China); College of Mechanical & Power Engineering, China Three Gorges University, No 8, Daxue Road, Yichang 443002, Hubei (China); Wang, Kunpeng [Nuclear and Radiation Safety Center, PO Box 8088, Beijing 100082 (China)

2016-04-15

Abstracts: A Small Modular fast reactor cooled by Supercritical CO{sub 2} (SMoSC) is pre-conceptually designed through three-dimensional coupled neutronics/thermal-hydraulics analysis. The power rating of the SMoSC is designed to be 300 MW{sub th} to meet the energy demand of small electrical grids. The excellent thermal properties of supercritical CO{sub 2} (S-CO{sub 2}) are employed to obtain a high thermal efficiency of about 40% with an electric output of 120 MWe. MOX fuel is utilized in the core design to improve fuel efficiency. The tube-in-duct (TID) assembly is applied to get lower coolant volume fraction and reduce the positive coolant void reactivity. According to the coupled neutronics/thermal-hydraulics calculations, the coolant void reactivity is kept negative throughout the whole core life. With a specific power density of 9.6 kW/kg and an average discharge burnup of 70.1 GWd/tHM, the SmoSC can be operated for 20 Effective Full Power Years (EFPYs) without refueling.

Plant operator selection system for evaluating employment candidates' potential for success in electric power plant operations positions

International Nuclear Information System (INIS)

Dunnette, M.D.

1982-01-01

The Plant Operator Selection System is a battery of tests and questionnaires that can be administered to job candidates in less than three hours. Various components of the battery measure what a job candidate has accomplished in previous educational and work situations, how well a candidate compares with others on a number of important aptitudes or abilities, and whether or not a candidate possesses the kind of personal stability required in power plant operations positions. A job candidate's answers to the tests and questionnaires of the Plant Operator Selection System are scored and converted to an OVERALL POTENTIAL INDEX. Values of the OVERALL POTENTIAL INDEX [OPI] range between 0 and 15. Candidates with high OPI values are much more likely to become effective and successful plant operators than candidates with low OPI values. It is possible to estimate the financial advantages to a company of using the Plant Operator Selection System in evaluating candidates for plant operations jobs

Preconceptual design for separation of plutonium and gallium by ion exchange

International Nuclear Information System (INIS)

DeMuth, S.F.

1997-01-01

The disposition of plutonium from decommissioned nuclear weapons, by incorporation into commercial UO 2 -based nuclear reactor fuel, is a viable means to reduce the potential for theft of excess plutonium. This fuel, which would be a combination of plutonium oxide and uranium oxide, is referred to as a mixed oxide (MOX). Following power generation in commercial reactors with this fuel, the remaining plutonium would become mixed with highly radioactive fission products in a spent fuel assembly. The radioactivity, complex chemical composition, and large size of this spent fuel assembly, would make theft difficult with elaborate chemical processing required for plutonium recovery. In fabricating the MOX fuel, it is important to maintain current commercial fuel purity specifications. While impurities from the weapons plutonium may or may not have a detrimental affect on the fuel fabrication or fuel/cladding performance, certifying the effect as insignificant could be more costly than purification. Two primary concerns have been raised with regard to the gallium impurity: (1) gallium vaporization during fuel sintering may adversely affect the MOX fuel fabrication process, and (2) gallium vaporization during reactor operation may adversely affect the fuel cladding performance. Consequently, processes for the separation of plutonium from gallium are currently being developed and/or designed. In particular, two separation processes are being considered: (1) a developmental, potentially lower cost and lower waste, thermal vaporization process following PuO 2 powder preparation, and (2) an off-the-shelf, potentially higher cost and higher waste, aqueous-based ion exchange (IX) process. While it is planned to use the thermal vaporization process should its development prove successful, IX has been recommended as a backup process. This report presents a preconceptual design with material balances for separation of plutonium from gallium by IX

Candidate innate immune system gene expression in the ecological model Daphnia.

Science.gov (United States)

Decaestecker, Ellen; Labbé, Pierrick; Ellegaard, Kirsten; Allen, Judith E; Little, Tom J

2011-10-01

The last ten years have witnessed increasing interest in host-pathogen interactions involving invertebrate hosts. The invertebrate innate immune system is now relatively well characterised, but in a limited range of genetic model organisms and under a limited number of conditions. Immune systems have been little studied under real-world scenarios of environmental variation and parasitism. Thus, we have investigated expression of candidate innate immune system genes in the water flea Daphnia, a model organism for ecological genetics, and whose capacity for clonal reproduction facilitates an exceptionally rigorous control of exposure dose or the study of responses at many time points. A unique characteristic of the particular Daphnia clones and pathogen strain combinations used presently is that they have been shown to be involved in specific host-pathogen coevolutionary interactions in the wild. We choose five genes, which are strong candidates to be involved in Daphnia-pathogen interactions, given that they have been shown to code for immune effectors in related organisms. Differential expression of these genes was quantified by qRT-PCR following exposure to the bacterial pathogen Pasteuria ramosa. Constitutive expression levels differed between host genotypes, and some genes appeared to show correlated expression. However, none of the genes appeared to show a major modification of expression level in response to Pasteuria exposure. By applying knowledge from related genetic model organisms (e.g. Drosophila) to models for the study of evolutionary ecology and coevolution (i.e. Daphnia), the candidate gene approach is temptingly efficient. However, our results show that detection of only weak patterns is likely if one chooses target genes for study based on previously identified genome sequences by comparison to homologues from other related organisms. Future work on the Daphnia-Pasteuria system will need to balance a candidate gene approach with more comprehensive

Environmental Systems Research Candidates FY-01 Annual Report

Energy Technology Data Exchange (ETDEWEB)

Miller, David Lynn; Piet, Steven James

2001-03-01

The Environmental Systems Research Candidates (ESRC) Program ran from April 2000 through September 2001 as part of the Environmental Systems Research and Analysis (ESRA) Program at the Idaho National Engineering and Environmental Laboratory (INEEL). ESRA provides key science and technology to meet the cleanup mission of the U.S. Department of Energy Office of Environmental Management (EM), and performs research and development that will help solve current legacy problems and enhance the INEEL’s scientific and technical capability for solving longer-term challenges. This report documents the accomplishments of the ESRC Program. The ESRC Program consisted of 25 tasks subdivided within four research areas.

Assessment of LWR spent fuel disposal options. Volume 3. Study bases and system design considerations (Appendices). Technical report

Energy Technology Data Exchange (ETDEWEB)

1979-07-01

Volume 3 (Appendices) provides a tabulation of the bases and assumptions used in the study as well as preconceptual design description and cost estimates of the facilities and transportation systems necessary to implement the various study cases.

Assessment of LWR spent fuel disposal options. Volume 3. Study bases and system design considerations (Appendices). Technical report

International Nuclear Information System (INIS)

1979-07-01

Volume 3 (Appendices) provides a tabulation of the bases and assumptions used in the study as well as preconceptual design description and cost estimates of the facilities and transportation systems necessary to implement the various study cases

Tokamak Fusion Core Experiment (TFCX) special-purpose remote maintenance systems

International Nuclear Information System (INIS)

Masson, L.S.; Welland, H.J.

1985-01-01

A key element in the preconceptual design of the Tokamak Fusion Core Experiment (TFCX) was the development of design concepts for special-purpose remote maintenance systems. Included were systems for shield sector replacement, vacuum vessel sector and toroidal field coil replacement, limiter blade replacement, protective tile replacement, and general-purpose maintenance. This paper addresses these systems as they apply to the copper toroidal field (TF) coil version of the TFCX

Design criteria and candidate electrical power systems for a reusable Space Shuttle booster.

Science.gov (United States)

Merrifield, D. V.

1972-01-01

This paper presents the results of a preliminary study to establish electrical power requirements, investigate candidate power sources, and select a representative power generation concept for the NASA Space Shuttle booster stage. Design guidelines and system performance requirements are established. Candidate power sources and combinations thereof are defined and weight estimates made. The selected power source concept utilizes secondary silver-zinc batteries, engine-driven alternators with constant speed drive, and an airbreathing gas turbine. The need for cost optimization, within safety, reliability, and performance constraints, is emphasized as being the most important criteria in design of the final system.

Causal fermion systems as a candidate for a unified physical theory

Science.gov (United States)

Finster, Felix; Kleiner, Johannes

2015-07-01

The theory of causal fermion systems is an approach to describe fundamental physics. Giving quantum mechanics, general relativity and quantum field theory as limiting cases, it is a candidate for a unified physical theory. We here give a non-technical introduction.

Architecture of Kepler's multi-transiting systems. II. New investigations with twice as many candidates

Energy Technology Data Exchange (ETDEWEB)

Fabrycky, Daniel C. [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); Lissauer, Jack J.; Rowe, Jason F.; Barclay, Thomas; Batalha, Natalie; Borucki, William; Jenkins, Jon M.; Li, Jie; Morris, Robert L.; Smith, Jeffrey C. [NASA Ames Research Center, Moffett Field, CA 94035 (United States); Ragozzine, Darin; Geary, John C.; Holman, Matthew J. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Steffen, Jason H. [Fermilab Center for Particle Astrophysics, P.O. Box 500, MS 127, Batavia, IL 60510 (United States); Agol, Eric [Department of Astronomy, University of Washington, P.O. Box 351580, Seattle, WA 98195 (United States); Ciardi, David R. [NASA Exoplanet Science Institute/Caltech, 770 South Wilson Avenue, MC 100-2, Pasadena, CA 91125 (United States); Ford, Eric B.; Morehead, Robert C. [Center for Exoplanets and Habitable Worlds, 525 Davey Laboratory, The Pennsylvania State University, University Park, PA 16802 (United States); Gautier, Thomas N.; Shporer, Avi, E-mail: fabrycky@uchicago.edu [Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, CA 91109 (United States); and others

2014-08-01

We report on the orbital architectures of Kepler systems having multiple-planet candidates identified in the analysis of data from the first six quarters of Kepler data and reported by Batalha et al. (2013). These data show 899 transiting planet candidates in 365 multiple-planet systems and provide a powerful means to study the statistical properties of planetary systems. Using a generic mass-radius relationship, we find that only two pairs of planets in these candidate systems (out of 761 pairs total) appear to be on Hill-unstable orbits, indicating ∼96% of the candidate planetary systems are correctly interpreted as true systems. We find that planet pairs show little statistical preference to be near mean-motion resonances. We identify an asymmetry in the distribution of period ratios near first-order resonances (e.g., 2:1, 3:2), with an excess of planet pairs lying wide of resonance and relatively few lying narrow of resonance. Finally, based upon the transit duration ratios of adjacent planets in each system, we find that the interior planet tends to have a smaller transit impact parameter than the exterior planet does. This finding suggests that the mode of the mutual inclinations of planetary orbital planes is in the range 1.°0-2.°2, for the packed systems of small planets probed by these observations.

Architecture of Kepler's multi-transiting systems. II. New investigations with twice as many candidates

International Nuclear Information System (INIS)

Fabrycky, Daniel C.; Lissauer, Jack J.; Rowe, Jason F.; Barclay, Thomas; Batalha, Natalie; Borucki, William; Jenkins, Jon M.; Li, Jie; Morris, Robert L.; Smith, Jeffrey C.; Ragozzine, Darin; Geary, John C.; Holman, Matthew J.; Steffen, Jason H.; Agol, Eric; Ciardi, David R.; Ford, Eric B.; Morehead, Robert C.; Gautier, Thomas N.; Shporer, Avi

2014-01-01

We report on the orbital architectures of Kepler systems having multiple-planet candidates identified in the analysis of data from the first six quarters of Kepler data and reported by Batalha et al. (2013). These data show 899 transiting planet candidates in 365 multiple-planet systems and provide a powerful means to study the statistical properties of planetary systems. Using a generic mass-radius relationship, we find that only two pairs of planets in these candidate systems (out of 761 pairs total) appear to be on Hill-unstable orbits, indicating ∼96% of the candidate planetary systems are correctly interpreted as true systems. We find that planet pairs show little statistical preference to be near mean-motion resonances. We identify an asymmetry in the distribution of period ratios near first-order resonances (e.g., 2:1, 3:2), with an excess of planet pairs lying wide of resonance and relatively few lying narrow of resonance. Finally, based upon the transit duration ratios of adjacent planets in each system, we find that the interior planet tends to have a smaller transit impact parameter than the exterior planet does. This finding suggests that the mode of the mutual inclinations of planetary orbital planes is in the range 1.°0-2.°2, for the packed systems of small planets probed by these observations.

Causal fermion systems as a candidate for a unified physical theory

International Nuclear Information System (INIS)

Finster, Felix; Kleiner, Johannes

2015-01-01

The theory of causal fermion systems is an approach to describe fundamental physics. Giving quantum mechanics, general relativity and quantum field theory as limiting cases, it is a candidate for a unified physical theory. We here give a non-technical introduction. (paper)

Combined cycle solar central receiver hybrid power system study. Volume III. Appendices. Final technical report

Energy Technology Data Exchange (ETDEWEB)

None

1979-11-01

A design study for a 100 MW gas turbine/steam turbine combined cycle solar/fossil-fuel hybrid power plant is presented. This volume contains the appendices: (a) preconceptual design data; (b) market potential analysis methodology; (c) parametric analysis methodology; (d) EPGS systems description; (e) commercial-scale solar hybrid power system assessment; and (f) conceptual design data lists. (WHK)

Does a Least-Preferred Candidate Win a Seat? A Comparison of Three Electoral Systems

Directory of Open Access Journals (Sweden)

Yoichi Hizen

2015-01-01

Full Text Available In this paper, the differences between two variations of proportional representation (PR, open-list PR and closed-list PR, are analyzed in terms of their ability to accurately reflect voter preference. The single nontransferable vote (SNTV is also included in the comparison as a benchmark. We construct a model of voting equilibria with a candidate who is least preferred by voters in the sense that replacing the least-preferred candidate in the set of winners with any loser is Pareto improving, and our focus is on whether the least-preferred candidate wins under each electoral system. We demonstrate that the least-preferred candidate never wins under the SNTV, but can win under open-list PR, although this is less likely than winning under closed-list PR.

Architecture of Kepler's Multi-transiting Systems: II. New investigations with twice as many candidates

Energy Technology Data Exchange (ETDEWEB)

Fabrycky, Daniel C.; Lissauer, Jack J.; Ragozzine, Darin; Rowe, Jason F.; Steffen, Jason H.; Agol, Eric; Barclay, Thomas; Batalha, Natalie; Borucki, William; Ciardi, David R.; Ford, Eric B.; Gautier, Thomas N.; Geary, John C.; Holman, Matthew J.; Jenkins, Jon M.; Li, Jie; Morehead, Robert C.; Morris, Robert L.; Shporer, Avi; Smith, Jeffrey C.; Still, Martin; Van Cleve, Jeffrey

2014-07-16

Having discovered 885 planet candidates in 361 multiple-planet systems, Kepler has made transits a powerful method for studying the statistics of planetary systems. The orbits of only two pairs of planets in these candidate systems are apparently unstable. This indicates that a high percentage of the candidate systems are truly planets orbiting the same star, motivating physical investigations of the population. Pairs of planets in this sample are typically not in orbital resonances. However, pairs with orbital period ratios within a few percent of a first-order resonance (e.g. 2:1, 3:2) prefer orbital spacings just wide of the resonance and avoid spacings just narrow of the resonance. Finally, we investigate mutual inclinations based on transit duration ratios. We infer that the inner planets of pairs tend to have a smaller impact parameter than their outer companions, suggesting these planetary systems are typically coplanar to within a few degrees.

K basins sludge removal sludge pretreatment system

International Nuclear Information System (INIS)

Chang, H.L.

1997-01-01

The Spent Nuclear Fuels Program is in the process of planning activities to remove spent nuclear fuel and other materials from the 100-K Basins as a remediation effort for clean closure. The 105 K- East and K-West Basins store spent fuel, sludge, and debris. Sludge has accumulated in the 1 00 K Basins as a result of fuel oxidation and a slight amount of general debris being deposited, by settling, in the basin water. The ultimate intent in removing the sludge and fuel is to eliminate the environmental risk posed by storing fuel at the K Basins. The task for this project is to disposition specific constituents of sludge (metallic fuel) to produce a product stream through a pretreatment process that will meet the requirements, including a final particle size acceptable to the Tank Waste Remediation System (TWRS). The purpose of this task is to develop a preconceptual design package for the K Basin sludge pretreatment system. The process equipment/system is at a preconceptual stage, as shown in sketch ES-SNF-01 , while a more refined process system and material/energy balances are ongoing (all sketches are shown in Appendix C). Thus, the overall process and 0535 associated equipment have been conservatively selected and sized, respectively, to establish the cost basis and equipment layout as shown in sketches ES- SNF-02 through 08

Characteristics study of bentonite as candidate of buffer materials for radioactive waste disposal system

International Nuclear Information System (INIS)

Suryantoro; Arimuladi, S.P.; Sastrowardoyo, P.B.

1998-01-01

Literature studies on bentonite characteristic of, as candidate for radioactive waste disposal system, have been conducted. Several information have been obtained from references, which would be contributed on performance assessment of engineered barrier. The functions bentonite includes the buffering of chemical and physical behavior, i.e. swelling property, self sealing, hydraulic conductivities and gas permeability. This paper also presented long-term stability of bentonite in natural condition related to the illitisazation, which could change its buffering capacities. These information, showed that bentonite was satisfied to be used for candidate of buffer materials in radioactive waste disposal system. (author)

Preconceptual ABC design definition and system configuration layout: Appendix A

International Nuclear Information System (INIS)

1995-03-01

The mission of the ABC system is to destroy as effectively as possible the fissile material inserted into the core without producing any new fissile material. The contents of this report are as follows: operating conditions for the steam-cycle ABC system; flow rates and component dimensions; drawings of the ABC layout; and impact of core design parameters on containment size

Next Generation Nuclear Plant Pre-Conceptual Design Report

International Nuclear Information System (INIS)

Larry Demick; Doug Vandel

2007-01-01

management of the project using commercial processes, share the cost of design and construction with the government, and secure a commercial nuclear operating company to operate the plant. In FY-07, Pre-Conceptual Design (PCD) work was completed by the NGNP Project at the INL with the objective of developing a framework in which the design and technology development of the NGNP could progress and to begin to develop bases for selection of the specific design and operational characteristics of NGNP. This work was completed by three contractor teams with extensive experience in HTGR technology, nuclear power applications, and hydrogen production. The teams were led by Westinghouse Electric Company, LLC; AREVA NP, Inc.; and General Atomics. The scope of work included completion of special studies to address key aspects of the NGNP (e.g., reactor type, power levels, power conversion system [PCS] and heat transfer/transport system [HTS] designs, licensing and end product disposition). The results of these special studies were applied to the development by each contractor of a recommended design for NGNP and a commercial version of the HTGR. These were then used to estimate costs and schedule for design; construction; licensing; startup and testing; operation; and deactivation, decontamination, and decommissioning (DD and D) of the NGNP and an economic assessment for an Nth of a kind (NOAK) commercial plant. A primary objective of this work is to identify research and development (R and D), data needs, and future studies required to support selection of key characteristics of and to support the design and licensing processes for the NGNP. The Preliminary Project Management Plan (PPMP) for the NGNP identifies two planning options that weigh a range of programmatic risks and approaches to mitigating risk. The two options are compliant with the EPAct, but emphasize different approaches to technology development risks, design and construction risks, and the extent of demonstration in

Facility Configuration Study of the High Temperature Gas-Cooled Reactor Component Test Facility

Energy Technology Data Exchange (ETDEWEB)

S. L. Austad; L. E. Guillen; D. S. Ferguson; B. L. Blakely; D. M. Pace; D. Lopez; J. D. Zolynski; B. L. Cowley; V. J. Balls; E.A. Harvego, P.E.; C.W. McKnight, P.E.; R.S. Stewart; B.D. Christensen

2008-04-01

A test facility, referred to as the High Temperature Gas-Cooled Reactor Component Test Facility or CTF, will be sited at Idaho National Laboratory for the purposes of supporting development of high temperature gas thermal-hydraulic technologies (helium, helium-Nitrogen, CO2, etc.) as applied in heat transport and heat transfer applications in High Temperature Gas-Cooled Reactors. Such applications include, but are not limited to: primary coolant; secondary coolant; intermediate, secondary, and tertiary heat transfer; and demonstration of processes requiring high temperatures such as hydrogen production. The facility will initially support completion of the Next Generation Nuclear Plant. It will secondarily be open for use by the full range of suppliers, end-users, facilitators, government laboratories, and others in the domestic and international community supporting the development and application of High Temperature Gas-Cooled Reactor technology. This pre-conceptual facility configuration study, which forms the basis for a cost estimate to support CTF scoping and planning, accomplishes the following objectives: • Identifies pre-conceptual design requirements • Develops test loop equipment schematics and layout • Identifies space allocations for each of the facility functions, as required • Develops a pre-conceptual site layout including transportation, parking and support structures, and railway systems • Identifies pre-conceptual utility and support system needs • Establishes pre-conceptual electrical one-line drawings and schedule for development of power needs.

Facility Configuration Study of the High Temperature Gas-Cooled Reactor Component Test Facility

International Nuclear Information System (INIS)

S. L. Austad; L. E. Guillen; D. S. Ferguson; B. L. Blakely; D. M. Pace; D. Lopez; J. D. Zolynski; B. L. Cowley; V. J. Balls; E.A. Harvego, P.E.; C.W. McKnight, P.E.; R.S. Stewart; B.D. Christensen

2008-01-01

A test facility, referred to as the High Temperature Gas-Cooled Reactor Component Test Facility or CTF, will be sited at Idaho National Laboratory for the purposes of supporting development of high temperature gas thermal-hydraulic technologies (helium, helium-Nitrogen, CO2, etc.) as applied in heat transport and heat transfer applications in High Temperature Gas-Cooled Reactors. Such applications include, but are not limited to: primary coolant; secondary coolant; intermediate, secondary, and tertiary heat transfer; and demonstration of processes requiring high temperatures such as hydrogen production. The facility will initially support completion of the Next Generation Nuclear Plant. It will secondarily be open for use by the full range of suppliers, end-users, facilitators, government laboratories, and others in the domestic and international community supporting the development and application of High Temperature Gas-Cooled Reactor technology. This pre-conceptual facility configuration study, which forms the basis for a cost estimate to support CTF scoping and planning, accomplishes the following objectives: (1) Identifies pre-conceptual design requirements; (2) Develops test loop equipment schematics and layout; (3) Identifies space allocations for each of the facility functions, as required; (4) Develops a pre-conceptual site layout including transportation, parking and support structures, and railway systems; (5) Identifies pre-conceptual utility and support system needs; and (6) Establishes pre-conceptual electrical one-line drawings and schedule for development of power needs

MRS/IS facility co-located with a repository: preconceptual design and life-cycle cost estimates

International Nuclear Information System (INIS)

Smith, R.I.; Nesbitt, J.F.

1982-11-01

A program is described to examine the various alternatives for monitored retrievable storage (MRS) and interim storage (IS) of spent nuclear fuel, solidified high-level waste (HLW), and transuranic (TRU) waste until appropriate geologic repository/repositories are available. The objectives of this study are: (1) to develop a preconceptual design for an MRS/IS facility that would become the principal surface facility for a deep geologic repository when the repository is opened, (2) to examine various issues such as transportation of wastes, licensing of the facility, and environmental concerns associated with operation of such a facility, and (3) to estimate the life cycle costs of the facility when operated in response to a set of scenarios which define the quantities and types of waste requiring storage in specific time periods, which generally span the years from 1990 until 2016. The life cycle costs estimated in this study include: the capital expenditures for structures, casks and/or drywells, storage areas and pads, and transfer equipment; the cost of staff labor, supplies, and services; and the incremental cost of transporting the waste materials from the site of origin to the MRS/IS facility. Three scenarios are examined to develop estimates of life cycle costs of the MRS/IS facility. In the first scenario, HLW canisters are stored, starting in 1990, until the co-located repository is opened in the year 1998. Additional reprocessing plants and repositories are placed in service at various intervals. In the second scenario, spent fuel is stored, starting in 1990, because the reprocessing plants are delayed in starting operations by 10 years, but no HLW is stored because the repositories open on schedule. In the third scenario, HLW is stored, starting in 1990, because the repositories are delayed 10 years, but the reprocessing plants open on schedule

Candidate glutamatergic neurons in the visual system of Drosophila.

Directory of Open Access Journals (Sweden)

Shamprasad Varija Raghu

Full Text Available The visual system of Drosophila contains approximately 60,000 neurons that are organized in parallel, retinotopically arranged columns. A large number of these neurons have been characterized in great anatomical detail. However, studies providing direct evidence for synaptic signaling and the neurotransmitter used by individual neurons are relatively sparse. Here we present a first layout of neurons in the Drosophila visual system that likely release glutamate as their major neurotransmitter. We identified 33 different types of neurons of the lamina, medulla, lobula and lobula plate. Based on the previous Golgi-staining analysis, the identified neurons are further classified into 16 major subgroups representing lamina monopolar (L, transmedullary (Tm, transmedullary Y (TmY, Y, medulla intrinsic (Mi, Mt, Pm, Dm, Mi Am, bushy T (T, translobula plate (Tlp, lobula intrinsic (Lcn, Lt, Li, lobula plate tangential (LPTCs and lobula plate intrinsic (LPi cell types. In addition, we found 11 cell types that were not described by the previous Golgi analysis. This classification of candidate glutamatergic neurons fosters the future neurogenetic dissection of information processing in circuits of the fly visual system.

Candidate cave entrances on Mars

Science.gov (United States)

Cushing, Glen E.

2012-01-01

This paper presents newly discovered candidate cave entrances into Martian near-surface lava tubes, volcano-tectonic fracture systems, and pit craters and describes their characteristics and exploration possibilities. These candidates are all collapse features that occur either intermittently along laterally continuous trench-like depressions or in the floors of sheer-walled atypical pit craters. As viewed from orbit, locations of most candidates are visibly consistent with known terrestrial features such as tube-fed lava flows, volcano-tectonic fractures, and pit craters, each of which forms by mechanisms that can produce caves. Although we cannot determine subsurface extents of the Martian features discussed here, some may continue unimpeded for many kilometers if terrestrial examples are indeed analogous. The features presented here were identified in images acquired by the Mars Odyssey's Thermal Emission Imaging System visible-wavelength camera, and by the Mars Reconnaissance Orbiter's Context Camera. Select candidates have since been targeted by the High-Resolution Imaging Science Experiment. Martian caves are promising potential sites for future human habitation and astrobiology investigations; understanding their characteristics is critical for long-term mission planning and for developing the necessary exploration technologies.

Borehole plugging of man-made accesses to a basalt repository: a preliminary study

International Nuclear Information System (INIS)

Taylor, C.L.; Anttonen, G.J.; O'Rourke, J.E.; Niccum, M.R.

1979-09-01

This report describes the status of work currently in progress for the Basalt Borehole Plugging Program (BBPP). The primary objectives of the BBPP outlined in this report have been met during this first phase of work. These objectives included: (1) the preparation of a preliminary list of candidate plug materials; (2) a description of available machinery capable of placing candidate plug materials; and (3) the development of physical and geochemical testing programs to help evaluate the chemical stability and physical properties of candidate plug materials. The most significant finding from work to date is that given reasonable regulatory criteria, nothing has been identified which would prevent design of a plug system to seal manmade openings leading to a nuclear waste repository in Columbia River basalt for significantly long periods of time (on the order of thousands of years). Work accomplished to date indicates that this plug system can be designed using both natural and manufactured materials and can be emplaced with existing placement machinery and modifications of that machinery. The objectives of Task II are to conduct laboratory tests to evaluate the suitability of preferred candidate materials for plugging boreholes in the proposed repository, select plug system(s), initiate preconceptual machinery design for the placement of materials in plug system(s), and prepare a preliminary Task II report. As with Task I project organization, Task II is divided into subtasks that are identified by written subtask work summaries

ALMOST ALL OF KEPLER'S MULTIPLE-PLANET CANDIDATES ARE PLANETS

International Nuclear Information System (INIS)

Lissauer, Jack J.; Rowe, Jason F.; Bryson, Stephen T.; Howell, Steve B.; Jenkins, Jon M.; Kinemuchi, Karen; Koch, David G.; Marcy, Geoffrey W.; Adams, Elisabeth; Fressin, Francois; Geary, John; Holman, Matthew J.; Ragozzine, Darin; Buchhave, Lars A.; Ciardi, David R.; Cochran, William D.; Fabrycky, Daniel C.; Ford, Eric B.; Morehead, Robert C.; Gilliland, Ronald L.

2012-01-01

We present a statistical analysis that demonstrates that the overwhelming majority of Kepler candidate multiple transiting systems (multis) indeed represent true, physically associated transiting planets. Binary stars provide the primary source of false positives among Kepler planet candidates, implying that false positives should be nearly randomly distributed among Kepler targets. In contrast, true transiting planets would appear clustered around a smaller number of Kepler targets if detectable planets tend to come in systems and/or if the orbital planes of planets encircling the same star are correlated. There are more than one hundred times as many Kepler planet candidates in multi-candidate systems as would be predicted from a random distribution of candidates, implying that the vast majority are true planets. Most of these multis are multiple-planet systems orbiting the Kepler target star, but there are likely cases where (1) the planetary system orbits a fainter star, and the planets are thus significantly larger than has been estimated, or (2) the planets orbit different stars within a binary/multiple star system. We use the low overall false-positive rate among Kepler multis, together with analysis of Kepler spacecraft and ground-based data, to validate the closely packed Kepler-33 planetary system, which orbits a star that has evolved somewhat off of the main sequence. Kepler-33 hosts five transiting planets, with periods ranging from 5.67 to 41 days.

Pre-Conceptual Design for Northstar ⁹⁹Mo Process Tritium Removal System

Energy Technology Data Exchange (ETDEWEB)

Nobile, Arthur [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Reichert, Heidi [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Hollis, William Kirk [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Taylor, Craig Michael [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Gordon, John Cameron [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Dale, Gregory E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2016-01-12

In this report we describe a preliminary concept for a Tritium Removal System (TRS) to remove tritium that is generated in the ⁹⁹Mo production process. Preliminary calculations have been performed to evaluate an approximate size for the system. The concept described utilizes well-established detritiation technology based on catalytic oxidation of tritium and tritiated hydrocarbons to water in a high temperature (400 °C) reactor and capture of water in a molecular sieve bed. The TRS concept involves use of a single system that would cycle through each of the seven online target systems and remove tritium that has been accumulated after one week’s run time. The TRS would perform cleanup operations on each target system for a period of approximately 24 hours. This would occur while the system is still online and just prior to target replacement, so tritium levels would at their minimum values for target replacement. In the concept, during normal operation a small fraction (1%) of the helium recirculating in the system would be diverted through the TRS and returned to the flow loop. With this approach sufficient levels of detritiation can be accomplished in a 24 hour period. In the study it was found that because of the need to maintain low oxygen levels in the system (<100 ppm) this increases the size of the catalytic reactor. As a result of this finding, consideration should be given to other methods for removing tritium from the system. Other methods such as catalytic exchange of tritium with an unsaturated organic compound and subsequent trapping on activated carbon or molecular sieve could offer advantages of reducing reactor size and operation at lower reactor temperature. However the most significant advantage of such an approach would be the ability to operate in very low oxygen environments, which would eliminate any concerns for oxidation of the target.

Five kepler target stars that show multiple transiting exoplanet candidates

DEFF Research Database (Denmark)

Steffen..[], Jason H.; Batalha, N. M.; Broucki, W J.

2010-01-01

We present and discuss five candidate exoplanetary systems identified with the Kepler spacecraft. These five systems show transits from multiple exoplanet candidates. Should these objects prove to be planetary in nature, then these five systems open new opportunities for the field of exoplanets a...

Changing Perceptions of Teacher Candidates in High-Needs Schools

Science.gov (United States)

DeJarnette, Nancy K.

2016-01-01

Candidates enter teacher education programs with established beliefs about diversity and urban education. These belief systems impact decisions that teacher candidates make both now and in the future. Providing opportunities for candidates to spend quality time in an urban Professional Development School (PDS) setting with the support and guidance…

Waiting narratives of lung transplant candidates.

Science.gov (United States)

Yelle, Maria T; Stevens, Patricia E; Lanuza, Dorothy M

2013-01-01

Before 2005, time accrued on the lung transplant waiting list counted towards who was next in line for a donor lung. Then in 2005 the lung allocation scoring system was implemented, which meant the higher the illness severity scores, the higher the priority on the transplant list. Little is known of the lung transplant candidates who were listed before 2005 and were caught in the transition when the lung allocation scoring system was implemented. A narrative analysis was conducted to explore the illness narratives of seven lung transplant candidates between 2006 and 2007. Arthur Kleinman's concept of illness narratives was used as a conceptual framework for this study to give voice to the illness narratives of lung transplant candidates. Results of this study illustrate that lung transplant candidates expressed a need to tell their personal story of waiting and to be heard. Recommendation from this study calls for healthcare providers to create the time to enable illness narratives of the suffering of waiting to be told. Narrative skills of listening to stories of emotional suffering would enhance how healthcare providers could attend to patients' stories and hear what is most meaningful in their lives.

Waiting Narratives of Lung Transplant Candidates

Directory of Open Access Journals (Sweden)

Maria T. Yelle

2013-01-01

Full Text Available Before 2005, time accrued on the lung transplant waiting list counted towards who was next in line for a donor lung. Then in 2005 the lung allocation scoring system was implemented, which meant the higher the illness severity scores, the higher the priority on the transplant list. Little is known of the lung transplant candidates who were listed before 2005 and were caught in the transition when the lung allocation scoring system was implemented. A narrative analysis was conducted to explore the illness narratives of seven lung transplant candidates between 2006 and 2007. Arthur Kleinman’s concept of illness narratives was used as a conceptual framework for this study to give voice to the illness narratives of lung transplant candidates. Results of this study illustrate that lung transplant candidates expressed a need to tell their personal story of waiting and to be heard. Recommendation from this study calls for healthcare providers to create the time to enable illness narratives of the suffering of waiting to be told. Narrative skills of listening to stories of emotional suffering would enhance how healthcare providers could attend to patients’ stories and hear what is most meaningful in their lives.

The DES Bright Arcs Survey: Hundreds of Candidate Strongly Lensed Galaxy Systems from the Dark Energy Survey Science Verification and Year 1 Observations

Energy Technology Data Exchange (ETDEWEB)

Diehl, H. T.; Buckley-Geer, E. J.; Lindgren, K. A.; Nord, B.; Gaitsch, H.; Gaitsch, S.; Lin, H.; Allam, S.; Odden, C.; Pellico, A.; Tucker, D. L.; Kuropatkin, N.; Soares-Santos, M. [Fermi National Accelerator Laboratory, P.O. Box 500, Batavia, IL 60510 (United States); Collett, T. E. [Institute of Cosmology and Gravitation, University of Portsmouth, Portsmouth, PO1 3FX (United Kingdom); Furlanetto, C.; Nightingale, J. [University of Nottingham, School of Physics and Astronomy, Nottingham NG7 2RD (United Kingdom); Gill, M. S. S. [SLAC National Accelerator Laboratory, Menlo Park, CA 94025 (United States); More, A. [Kavli IPMU (WPI), UTIAS, The University of Tokyo, Kashiwa, Chiba 277-8583 (Japan); Costa, L. N. da; Neto, A. Fausti, E-mail: diehl@fnal.gov [Laboratório Interinstitucional de e-Astronomia—LIneA, Rua Gal. José Cristino 77, Rio de Janeiro, RJ—20921-400 (Brazil); Collaboration: DES Collaboration; and others

2017-09-01

We report the results of searches for strong gravitational lens systems in the Dark Energy Survey (DES) Science Verification and Year 1 observations. The Science Verification data span approximately 250 sq. deg. with a median i -band limiting magnitude for extended objects (10 σ ) of 23.0. The Year 1 data span approximately 2000 sq. deg. and have an i -band limiting magnitude for extended objects (10 σ ) of 22.9. As these data sets are both wide and deep, they are particularly useful for identifying strong gravitational lens candidates. Potential strong gravitational lens candidate systems were initially identified based on a color and magnitude selection in the DES object catalogs or because the system is at the location of a previously identified galaxy cluster. Cutout images of potential candidates were then visually scanned using an object viewer and numerically ranked according to whether or not we judged them to be likely strong gravitational lens systems. Having scanned nearly 400,000 cutouts, we present 374 candidate strong lens systems, of which 348 are identified for the first time. We provide the R.A. and decl., the magnitudes and photometric properties of the lens and source objects, and the distance (radius) of the source(s) from the lens center for each system.

Query by image example: The CANDID approach

Energy Technology Data Exchange (ETDEWEB)

Kelly, P.M.; Cannon, M. [Los Alamos National Lab., NM (United States). Computer Research and Applications Group; Hush, D.R. [Univ. of New Mexico, Albuquerque, NM (United States). Dept. of Electrical and Computer Engineering

1995-02-01

CANDID (Comparison Algorithm for Navigating Digital Image Databases) was developed to enable content-based retrieval of digital imagery from large databases using a query-by-example methodology. A user provides an example image to the system, and images in the database that are similar to that example are retrieved. The development of CANDID was inspired by the N-gram approach to document fingerprinting, where a ``global signature`` is computed for every document in a database and these signatures are compared to one another to determine the similarity between any two documents. CANDID computes a global signature for every image in a database, where the signature is derived from various image features such as localized texture, shape, or color information. A distance between probability density functions of feature vectors is then used to compare signatures. In this paper, the authors present CANDID and highlight two results from their current research: subtracting a ``background`` signature from every signature in a database in an attempt to improve system performance when using inner-product similarity measures, and visualizing the contribution of individual pixels in the matching process. These ideas are applicable to any histogram-based comparison technique.

Design requirement for electrical system of an advanced research reactor

International Nuclear Information System (INIS)

Jung, Hoan Sung; Kim, H. K.; Kim, Y. K.; Wu, J. S.; Ryu, J. S.

2004-12-01

An advanced research reactor is being designed since 2002 and the conceptual design has been completed this year for the several types of core. Also the fuel was designed for the potential cores. But the process system, the I and C system, and the electrical system design are under pre-conceptual stage. The conceptual design for those systems will be developed in the next year. Design requirements for the electrical system set up to develop conceptual design. The same goals as reactor design - enhance safety, reliability, economy, were applied for the development of the requirements. Also the experience of HANARO design and operation was based on. The design requirements for the power distribution, standby power supply, and raceway system will be used for the conceptual design of electrical system

Design requirement for electrical system of an advanced research reactor

Energy Technology Data Exchange (ETDEWEB)

Jung, Hoan Sung; Kim, H. K.; Kim, Y. K.; Wu, J. S.; Ryu, J. S

2004-12-01

An advanced research reactor is being designed since 2002 and the conceptual design has been completed this year for the several types of core. Also the fuel was designed for the potential cores. But the process system, the I and C system, and the electrical system design are under pre-conceptual stage. The conceptual design for those systems will be developed in the next year. Design requirements for the electrical system set up to develop conceptual design. The same goals as reactor design - enhance safety, reliability, economy, were applied for the development of the requirements. Also the experience of HANARO design and operation was based on. The design requirements for the power distribution, standby power supply, and raceway system will be used for the conceptual design of electrical system.

ALMOST ALL OF KEPLER'S MULTIPLE-PLANET CANDIDATES ARE PLANETS

Energy Technology Data Exchange (ETDEWEB)

Lissauer, Jack J.; Rowe, Jason F.; Bryson, Stephen T.; Howell, Steve B.; Jenkins, Jon M.; Kinemuchi, Karen; Koch, David G. [NASA Ames Research Center, Moffett Field, CA 94035 (United States); Marcy, Geoffrey W. [Astronomy Department, University of California, Berkeley, CA 94720 (United States); Adams, Elisabeth; Fressin, Francois; Geary, John; Holman, Matthew J.; Ragozzine, Darin [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Buchhave, Lars A. [Niels Bohr Institute, University of Copenhagen, DK-2100, Copenhagen (Denmark); Ciardi, David R. [Exoplanet Science Institute/Caltech, Pasadena, CA 91125 (United States); Cochran, William D. [Department of Astronomy, University of Texas, Austin, TX 78712 (United States); Fabrycky, Daniel C. [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); Ford, Eric B.; Morehead, Robert C. [University of Florida, 211 Bryant Space Science Center, Gainesville, FL 32611 (United States); Gilliland, Ronald L., E-mail: Jack.Lissauer@nasa.gov [Space Telescope Science Institute, Baltimore, MD 21218 (United States); and others

2012-05-10

We present a statistical analysis that demonstrates that the overwhelming majority of Kepler candidate multiple transiting systems (multis) indeed represent true, physically associated transiting planets. Binary stars provide the primary source of false positives among Kepler planet candidates, implying that false positives should be nearly randomly distributed among Kepler targets. In contrast, true transiting planets would appear clustered around a smaller number of Kepler targets if detectable planets tend to come in systems and/or if the orbital planes of planets encircling the same star are correlated. There are more than one hundred times as many Kepler planet candidates in multi-candidate systems as would be predicted from a random distribution of candidates, implying that the vast majority are true planets. Most of these multis are multiple-planet systems orbiting the Kepler target star, but there are likely cases where (1) the planetary system orbits a fainter star, and the planets are thus significantly larger than has been estimated, or (2) the planets orbit different stars within a binary/multiple star system. We use the low overall false-positive rate among Kepler multis, together with analysis of Kepler spacecraft and ground-based data, to validate the closely packed Kepler-33 planetary system, which orbits a star that has evolved somewhat off of the main sequence. Kepler-33 hosts five transiting planets, with periods ranging from 5.67 to 41 days.

Government instability shifts skin tone representations of and intentions to vote for political candidates.

Science.gov (United States)

Stern, Chadly; Balcetis, Emily; Cole, Shana; West, Tessa V; Caruso, Eugene M

2016-01-01

Does government stability shift the way White and Black Americans represent and make voting decisions about political candidates? Participants judged how representative lightened, darkened, and unaltered photographs were of a racially ambiguous candidate ostensibly running for political office (Studies 1-3). When the governmental system was presented as stable, White participants who shared (vs. did not share) the candidate's political beliefs rated a lightened photo as more representative of the candidate, and Black participants who shared (vs. did not share) the candidate's political beliefs rated a darkened photo as more representative (Studies 1-3). However, under conditions of instability, both Whites and Blacks who shared (vs. did not share) the candidate's political beliefs rated a lightened photo as more representative (Study 3). Representations of (Studies 2 and 3) and actual differences in (Studies 4a and 4b) skin tone predicted intentions to vote for candidates, as a function of government stability and participants' race. Further evidence suggested that system stability shifted the motivations that guided voting decisions (Study 4a and 4b). When the system was stable, the motivation to enhance one's group predicted greater intentions to vote for lighter skinned candidates among Whites, and greater intentions to vote for darker skinned candidates among Blacks. When the system was unstable, however, lacking confidence in the sociopolitical system predicted intentions to vote for lighter skinned candidates among both Whites and Blacks. Implications for political leadership and social perception are discussed. (c) 2016 APA, all rights reserved).

ON THE RELATIVE SIZES OF PLANETS WITHIN KEPLER MULTIPLE-CANDIDATE SYSTEMS

International Nuclear Information System (INIS)

Ciardi, David R.; Fabrycky, Daniel C.; Ford, Eric B.; Ragozzine, Darin; Gautier, T. N. III; Howell, Steve B.; Lissauer, Jack J.; Rowe, Jason F.

2013-01-01

We present a study of the relative sizes of planets within the multiple-candidate systems discovered with the Kepler mission. We have compared the size of each planet to the size of every other planet within a given planetary system after correcting the sample for detection and geometric biases. We find that for planet pairs for which one or both objects are approximately Neptune-sized or larger, the larger planet is most often the planet with the longer period. No such size-location correlation is seen for pairs of planets when both planets are smaller than Neptune. Specifically, if at least one planet in a planet pair has a radius of ∼> 3 R ⊕ , 68% ± 6% of the planet pairs have the inner planet smaller than the outer planet, while no preferred sequential ordering of the planets is observed if both planets in a pair are smaller than ∼ ⊕ .

Validation of Kepler's multiple planet candidates. III. Light curve analysis and announcement of hundreds of new multi-planet systems

International Nuclear Information System (INIS)

Rowe, Jason F.; Bryson, Stephen T.; Lissauer, Jack J.; Jontof-Hutter, Daniel; Mullally, Fergal; Howell, Steve B.; Borucki, William J.; Haas, Michael; Huber, Daniel; Thompson, Susan E.; Quintana, Elisa; Barclay, Thomas; Still, Martin; Marcy, Geoffrey W.; Issacson, Howard; Gilliland, Ronald L.; Ford, Eric; Steffen, Jason H.; Fortney, Jonathan; Gautier, T. N. III

2014-01-01

The Kepler mission has discovered more than 2500 exoplanet candidates in the first two years of spacecraft data, with approximately 40% of those in candidate multi-planet systems. The high rate of multiplicity combined with the low rate of identified false positives indicates that the multiplanet systems contain very few false positive signals due to other systems not gravitationally bound to the target star. False positives in the multi-planet systems are identified and removed, leaving behind a residual population of candidate multi-planet transiting systems expected to have a false positive rate less than 1%. We present a sample of 340 planetary systems that contain 851 planets that are validated to substantially better than the 99% confidence level; the vast majority of these have not been previously verified as planets. We expect ∼two unidentified false positives making our sample of planet very reliable. We present fundamental planetary properties of our sample based on a comprehensive analysis of Kepler light curves, ground-based spectroscopy, and high-resolution imaging. Since we do not require spectroscopy or high-resolution imaging for validation, some of our derived parameters for a planetary system may be systematically incorrect due to dilution from light due to additional stars in the photometric aperture. Nonetheless, our result nearly doubles the number verified exoplanets.

Design of lead-free candidate alloys for high-temperature soldering based on the Au–Sn system

DEFF Research Database (Denmark)

Chidambaram, Vivek; Hattel, Jesper Henri; Hald, John

2010-01-01

of the Au–Sn binary system were explored in this work. Furthermore, the effects of thermal aging on the microstructure and microhardness of these promising Au–Sn based ternary alloys were investigated. For this purpose, the candidate alloys were aged at a lower temperature, 150°C for up to 1week...

Mobile encapsulation and volume reduction system for wet low-level wastes

International Nuclear Information System (INIS)

Buelt, J.L.

1985-08-01

This report describes the results of the program entitled ''A Preconceptual Study for a Transportable Vitrification Process''. The objective of the study is to determine the feasibility of a Mobile Encapsulation and Volume Reduction System (MEVS). The report contains design criteria, a preconceptual design of the system, a comparison of disposal costs with other solidification technologies, and an assessment of utility interests in the transportable volume reduction service MEVS can provide. The MEVS design employs the use of a joule-heated glass melter to convert the wet low-level wastes into glass. The process is self-sufficient, requiring no direct facility services or reactor personnel. It is capable of servicing one waste type from a minimum of three reactors. The design was used to prepare capital and operating cost estimates. The capital cost for the MEVS is $4,680,000, which includes all labor necessary for design, engineering, inspection, and licensing. The operating cost of the system for servicing a minimum of three reactors is $1,530,000/y for resins or $2,280,000/y for concentrated liquids. The cost estimates compared favorably to the more common solidification process of cementation. Total MEVS operating costs which include processing, transportation and burial, are $191 to $218/ft 3 waste, whereas quoted costs for cementation and disposal from reactor operators range from $155 to $350/ft 3 . The report concludes with the requirements for additional development, which can be accomplished for less than one sixth of the capital costs. The report also presents the results of an assessment conducted with utility representatives to obtain their expressions of interest in a service of this type

Mortality Salience, System Justification, and Candidate Evaluations in the 2012 U.S. Presidential Election.

Directory of Open Access Journals (Sweden)

Joanna Sterling

Full Text Available Experiments conducted during the 2004 and 2008 U.S. presidential elections suggested that mortality salience primes increased support for President George W. Bush and Senator John McCain, respectively. Some interpreted these results as reflecting "conservative shift" following exposure to threat, whereas others emphasized preferences for "charismatic" leadership following exposure to death primes. To assess both hypotheses in the context of a new election cycle featuring a liberal incumbent who was considered to be charismatic, we conducted four experiments shortly before the 2012 election involving President Barack Obama and Governor Mitt Romney. Contrary to earlier studies, there was little evidence that mortality salience, either by itself or in interaction with political orientation, affected overall candidate ratings or voting intentions. However, a significant interaction between mortality salience and system justification in some studies indicated a more circumscribed effect. The failure to "replicate" previous results in the context of this election may be attributable to disagreement among participants as to which of the candidates better represented the societal status quo.

Validation of Kepler's multiple planet candidates. II. Refined statistical framework and descriptions of systems of special interest

International Nuclear Information System (INIS)

Lissauer, Jack J.; Bryson, Stephen T.; Rowe, Jason F.; Jontof-Hutter, Daniel; Borucki, William J.; Marcy, Geoffrey W.; Kolbl, Rea; Agol, Eric; Carter, Joshua A.; Torres, Guillermo; Ford, Eric B.; Gilliland, Ronald L.; Star, Kimberly M.; Steffen, Jason H.

2014-01-01

We extend the statistical analysis performed by Lissauer et al. in 2012, which demonstrates that the overwhelming majority of Kepler candidate multiple transiting systems (multis) represents true transiting planets, and we develop therefrom a procedure to validate large numbers of planet candidates in multis as bona fide exoplanets. We show that this statistical framework correctly estimates the abundance of false positives already identified around Kepler targets with multiple sets of transit-like signatures based on their abundance around targets with single sets of transit-like signatures. We estimate the number of multis that represent split systems of one or more planets orbiting each component of a binary star system. We use the high reliability rate for multis to validate more than one dozen particularly interesting multi-planet systems herein. Hundreds of additional multi-planet systems are validated in a companion paper by Rowe et al. We note that few very short period (P < 1.6 days) planets orbit within multiple transiting planet systems and discuss possible reasons for their absence. There also appears to be a shortage of planets with periods exceeding a few months in multis.

Validation of Kepler's multiple planet candidates. II. Refined statistical framework and descriptions of systems of special interest

Energy Technology Data Exchange (ETDEWEB)

Lissauer, Jack J.; Bryson, Stephen T.; Rowe, Jason F.; Jontof-Hutter, Daniel; Borucki, William J. [NASA Ames Research Center, Moffett Field, CA 94035 (United States); Marcy, Geoffrey W.; Kolbl, Rea [Astronomy Department, University of California, Berkeley, CA 94720 (United States); Agol, Eric [Department of Astronomy, Box 351580, University of Washington, Seattle, WA 98195 (United States); Carter, Joshua A.; Torres, Guillermo [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Ford, Eric B.; Gilliland, Ronald L.; Star, Kimberly M. [Department of Astronomy and Astrophysics, 525 Davey Laboratory, The Pennsylvania State University, University Park, PA 16802 (United States); Steffen, Jason H., E-mail: Jack.Lissauer@nasa.gov [Department of Physics and Astronomy/CIERA, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208 (United States)

2014-03-20

We extend the statistical analysis performed by Lissauer et al. in 2012, which demonstrates that the overwhelming majority of Kepler candidate multiple transiting systems (multis) represents true transiting planets, and we develop therefrom a procedure to validate large numbers of planet candidates in multis as bona fide exoplanets. We show that this statistical framework correctly estimates the abundance of false positives already identified around Kepler targets with multiple sets of transit-like signatures based on their abundance around targets with single sets of transit-like signatures. We estimate the number of multis that represent split systems of one or more planets orbiting each component of a binary star system. We use the high reliability rate for multis to validate more than one dozen particularly interesting multi-planet systems herein. Hundreds of additional multi-planet systems are validated in a companion paper by Rowe et al. We note that few very short period (P < 1.6 days) planets orbit within multiple transiting planet systems and discuss possible reasons for their absence. There also appears to be a shortage of planets with periods exceeding a few months in multis.

TWO NEARBY SUB-EARTH-SIZED EXOPLANET CANDIDATES IN THE GJ 436 SYSTEM

International Nuclear Information System (INIS)

Stevenson, Kevin B.; Harrington, Joseph; Lust, Nate B.; Blecic, Jasmina; Hardy, Ryan A.; Cubillos, Patricio; Campo, Christopher J.; Lewis, Nikole K.; Montagnier, Guillaume; Moses, Julianne I.; Visscher, Channon

2012-01-01

We report the detection of UCF-1.01, a strong exoplanet candidate with a radius 0.66 ± 0.04 times that of Earth (R ⊕ ). This sub-Earth-sized planet transits the nearby M-dwarf star GJ 436 with a period of 1.365862 ± 8 × 10 –6 days. We also report evidence of a 0.65 ± 0.06 R ⊕ exoplanet candidate (labeled UCF-1.02) orbiting the same star with an undetermined period. Using the Spitzer Space Telescope, we measure the dimming of light as the planets pass in front of their parent star to assess their sizes and orbital parameters. If confirmed today, UCF-1.01 and UCF-1.02 would be designated GJ 436c and GJ 436d, respectively, and would be part of the first multiple-transiting-planet system outside of the Kepler field. Assuming Earth-like densities of 5.515 g cm –3 , we predict both candidates to have similar masses (∼0.28 Earth-masses, M ⊕ , 2.6 Mars-masses) and surface gravities of ∼0.65 g (where g is the gravity on Earth). UCF-1.01's equilibrium temperature (T eq , where emitted and absorbed radiation balance for an equivalent blackbody) is 860 K, making the planet unlikely to harbor life as on Earth. Its weak gravitational field and close proximity to its host star imply that UCF-1.01 is unlikely to have retained its original atmosphere; however, a transient atmosphere is possible if recent impacts or tidal heating were to supply volatiles to the surface. We also present additional observations of GJ 436b during secondary eclipse. The 3.6 μm light curve shows indications of stellar activity, making a reliable secondary eclipse measurement impossible. A second non-detection at 4.5 μm supports our previous work in which we find a methane-deficient and carbon monoxide-rich dayside atmosphere.

Two nearby Sub-Earth-sized Exoplanet Candidates in the GJ 436 System

Science.gov (United States)

Stevenson, Kevin B.; Harrington, Joseph; Lust, Nate B.; Lewis, Nikole K.; Montagnier, Guillaume; Moses, Julianne I.; Visscher, Channon; Blecic, Jasmina; Hardy, Ryan A.; Cubillos, Patricio; Campo, Christopher J.

2012-08-01

We report the detection of UCF-1.01, a strong exoplanet candidate with a radius 0.66 ± 0.04 times that of Earth (R ⊕). This sub-Earth-sized planet transits the nearby M-dwarf star GJ 436 with a period of 1.365862 ± 8 × 10-6 days. We also report evidence of a 0.65 ± 0.06 R ⊕ exoplanet candidate (labeled UCF-1.02) orbiting the same star with an undetermined period. Using the Spitzer Space Telescope, we measure the dimming of light as the planets pass in front of their parent star to assess their sizes and orbital parameters. If confirmed today, UCF-1.01 and UCF-1.02 would be designated GJ 436c and GJ 436d, respectively, and would be part of the first multiple-transiting-planet system outside of the Kepler field. Assuming Earth-like densities of 5.515 g cm-3, we predict both candidates to have similar masses (~0.28 Earth-masses, M ⊕, 2.6 Mars-masses) and surface gravities of ~0.65 g (where g is the gravity on Earth). UCF-1.01's equilibrium temperature (T eq, where emitted and absorbed radiation balance for an equivalent blackbody) is 860 K, making the planet unlikely to harbor life as on Earth. Its weak gravitational field and close proximity to its host star imply that UCF-1.01 is unlikely to have retained its original atmosphere; however, a transient atmosphere is possible if recent impacts or tidal heating were to supply volatiles to the surface. We also present additional observations of GJ 436b during secondary eclipse. The 3.6 μm light curve shows indications of stellar activity, making a reliable secondary eclipse measurement impossible. A second non-detection at 4.5 μm supports our previous work in which we find a methane-deficient and carbon monoxide-rich dayside atmosphere.

Pilot study on the use of data mining to identify cochlear implant candidates.

Science.gov (United States)

Grisel, Jedidiah J; Schafer, Erin; Lam, Anne; Griffin, Terry

2018-05-01

The goal of this pilot study was to determine the clinical utility of data-mining software that screens for cochlear implant (CI) candidacy. The Auditory Implant Initiative developed a software module that screens for CI candidates via integration with a software system (Noah 4) that serves as a depository for hearing test data. To identify candidates, patient audiograms from one practice were exported into the screening module. Candidates were tracked to determine if any eventually underwent implantation. After loading 4836 audiograms from the Noah 4 system, the screening module identified 558 potential CI candidates. After reviewing the data for the potential candidates, 117 were targeted and invited to an educational event. Following the event, a total of six candidates were evaluated, and two were implanted. This objective approach to identifying candidates has the potential to address the gross underutilization of CIs by removing any bias or lack of knowledge regarding the management of severe to profound sensorineural hearing loss with CIs. The screening module was an effective tool for identifying potential CI candidates at one ENT practice. On a larger scale, the screening module has the potential to impact thousands of CI candidates worldwide.

GENERACIÓN DEL DIAGRAMA DE SECUENCIAS DE UML 2.1.1 DESDE ESQUEMAS PRECONCEPTUALES GENERATION OF UML 2.1.1 SEQUENCE DIAGRAM FROM PRE-CONCEPTUAL SCHEMES

Directory of Open Access Journals (Sweden)

Carlos Mario Zapata

2008-12-01

Full Text Available El diagrama de secuencias es un esquema conceptual que permite representar el comportamiento de un sistema, para lo cual emplea la especificación de los objetos que se encuentran en un escenario y la secuencia de mensajes intercambiados entre ellos, con el fin de llevar a cabo una transacción del sistema. Existen diferentes enfoques que buscan la generación automática de modelos conceptuales, como el diagrama de secuencias. Algunos trabajos parten del lenguaje natural, pero generan diagramas diferentes al de secuencias o, si lo hacen igual, dejan de lado elementos como los fragmentos combinados, que describen ciertas condiciones lógicas en el sistema. Otros trabajos parten del código fuente, el cual se suele ubicar en una fase más avanzada del ciclo de vida del software. En este artículo se define un método, basado en reglas heurísticas, que permite identificar los elementos del diagrama de secuencias, incluyendo los fragmentos combinados, tomando como punto de partida los esquemas preconceptuales. Se realiza la implementación de las reglas en la herramienta AToM³ aplicándolas a un caso de estudio.Sequence diagram is a conceptual schema for representing behavior of a system. For performing such a task, it employs the object spec from a scenario and the sequence of messages exchanged among the objects. These elements describe a transaction of the system. Several approaches try the automated generation of conceptual models (like sequence diagram. Some of them use natural language as a starting point, but they are focused on other diagrams. Some others are focused on sequence diagram, but they do not obtain elements like combined fragments describing several logical constraints of the system. Other approaches use source code as a starting point, but source code can be related to an advanced phase of the software development life cycle. In this paper we define a method based on heuristic rules for obtaining automatically the elements of

Five Kepler target stars that show multiple transiting exoplanet candidates

Energy Technology Data Exchange (ETDEWEB)

Steffen, Jason H.; /Fermilab; Batalha, Natalie M.; /San Jose State U.; Borucki, William J.; /NASA, Ames; Buchhave, Lars A.; /Harvard-Smithsonian Ctr. Astrophys. /Bohr Inst.; Caldwell, Douglas A.; /NASA, Ames /SETI Inst., Mtn. View; Cochran, William D.; /Texas U.; Endl, Michael; /Texas U.; Fabrycky, Daniel C.; /Harvard-Smithsonian Ctr. Astrophys.; Fressin, Francois; /Harvard-Smithsonian Ctr. Astrophys.; Ford, Eric B.; /Florida U.; Fortney, Jonathan J.; /UC, Santa Cruz, Phys. Dept. /NASA, Ames

2010-06-01

We present and discuss five candidate exoplanetary systems identified with the Kepler spacecraft. These five systems show transits from multiple exoplanet candidates. Should these objects prove to be planetary in nature, then these five systems open new opportunities for the field of exoplanets and provide new insights into the formation and dynamical evolution of planetary systems. We discuss the methods used to identify multiple transiting objects from the Kepler photometry as well as the false-positive rejection methods that have been applied to these data. One system shows transits from three distinct objects while the remaining four systems show transits from two objects. Three systems have planet candidates that are near mean motion commensurabilities - two near 2:1 and one just outside 5:2. We discuss the implications that multitransiting systems have on the distribution of orbital inclinations in planetary systems, and hence their dynamical histories; as well as their likely masses and chemical compositions. A Monte Carlo study indicates that, with additional data, most of these systems should exhibit detectable transit timing variations (TTV) due to gravitational interactions - though none are apparent in these data. We also discuss new challenges that arise in TTV analyses due to the presence of more than two planets in a system.

Depleted uranium plasma reduction system study

International Nuclear Information System (INIS)

Rekemeyer, P.; Feizollahi, F.; Quapp, W.J.; Brown, B.W.

1994-12-01

A system life-cycle cost study was conducted of a preliminary design concept for a plasma reduction process for converting depleted uranium to uranium metal and anhydrous HF. The plasma-based process is expected to offer significant economic and environmental advantages over present technology. Depleted Uranium is currently stored in the form of solid UF 6 , of which approximately 575,000 metric tons is stored at three locations in the U.S. The proposed system is preconceptual in nature, but includes all necessary processing equipment and facilities to perform the process. The study has identified total processing cost of approximately $3.00/kg of UF 6 processed. Based on the results of this study, the development of a laboratory-scale system (1 kg/h throughput of UF6) is warranted. Further scaling of the process to pilot scale will be determined after laboratory testing is complete

Citizen Candidates Under Uncertainty

OpenAIRE

Eguia, Jon X.

2005-01-01

In this paper we make two contributions to the growing literature on "citizen-candidate" models of representative democracy. First, we add uncertainty about the total vote count. We show that in a society with a large electorate, where the outcome of the election is uncertain and where winning candidates receive a large reward from holding office, there will be a two-candidate equilibrium and no equilibria with a single candidate. Second, we introduce a new concept of equilibrium, which we te...

INVESTIGATING THE OPTICAL COUNTERPART CANDIDATES OF FOUR INTEGRAL SOURCES LOCALIZED WITH CHANDRA

International Nuclear Information System (INIS)

Özbey Arabacı, Mehtap; Kalemci, Emrah; Tomsick, John A.; Bodaghee, Arash; Halpern, Jules; Chaty, Sylvain; Rodriguez, Jerome; Rahoui, Farid

2012-01-01

We report on the optical spectroscopic follow-up observations of the candidate counterparts to four INTEGRAL sources: IGR J04069+5042, IGR J06552–1146, IGR J21188+4901, and IGR J22014+6034. The candidate counterparts were determined with Chandra, and the optical observations were performed with 1.5 m RTT-150 telescope (TÜBİTAK National Observatory, Antalya, Turkey) and 2.4 m Hiltner Telescope (MDM Observatory, Kitt Peak, Arizona). Our spectroscopic results show that one of the two candidates of IGR J04069+5042 and the one observed for IGR J06552–1146 could be active late-type stars in RS CVn systems. However, according to the likelihood analysis based on Chandra and INTEGRAL, two optically weaker sources in the INTEGRAL error circle of IGR J06552–1146 have higher probabilities to be the actual counterpart. The candidate counterparts of IGR J21188+4901 are classified as an active M-type star and a late-type star. Among the optical spectra of four candidates of IGR J22014+6034, two show Hα emission lines, one is a late-type star, and the other is an M type. The likelihood analysis favors a candidate with no distinguishing features in the optical spectrum. Two of the candidates classified as M-type dwarfs, are similar to some IGR candidates claimed to be symbiotic stars. However, some of the prominent features of symbiotic systems are missing in our spectra, and their NIR colors are not consistent with those expected for giants. We consider the IR colors of all IGR candidates claimed to be symbiotic systems and find that low-resolution optical spectrum may not be enough for conclusive identification.

Warm Debris Disk Candidates from WISE

Science.gov (United States)

Padgett, Deborah; Stapelfeldt, Karl; Liu, Wilson; Leisawitz, David

2011-01-01

The Wide Field Infrared Survey Explorer (WISE) has just completed a sensitive all-sky survey in photometric bands at 3.4, 4.6, 12, and 22 microns. We report on a preliminary investigation of main sequence Hipparcos and Tycho catalog stars with 22 micron emission in excess of photospheric levels. This warm excess emission traces material in the circumstellar region likely to host terrestrial planets and is preferentially found in young systems with ages warm debris disk candidates are detected among FGK stars and 150 A stars within 120 pc. We are in the process of obtaining spectra to determine spectral types and activity level of these stars and are using HST, Herschel and Keck to characterize the dust, multiplicity, and substellar companions of these systems. In this contribution, we will discuss source selection methods and individual examples from among the WISE debris disk candidates.

Characteristics of Planetary Candidates Observed by Kepler. II. Analysis of the First Four Months of Data

Science.gov (United States)

Borucki, William J.; Koch, David G.; Basri, Gibor; Batalha, Natalie; Brown, Timothy M.; Bryson, Stephen T.; Caldwell, Douglas; Christensen-Dalsgaard, Jørgen; Cochran, William D.; DeVore, Edna; Dunham, Edward W.; Gautier, Thomas N., III; Geary, John C.; Gilliland, Ronald; Gould, Alan; Howell, Steve B.; Jenkins, Jon M.; Latham, David W.; Lissauer, Jack J.; Marcy, Geoffrey W.; Rowe, Jason; Sasselov, Dimitar; Boss, Alan; Charbonneau, David; Ciardi, David; Doyle, Laurance; Dupree, Andrea K.; Ford, Eric B.; Fortney, Jonathan; Holman, Matthew J.; Seager, Sara; Steffen, Jason H.; Tarter, Jill; Welsh, William F.; Allen, Christopher; Buchhave, Lars A.; Christiansen, Jessie L.; Clarke, Bruce D.; Das, Santanu; Désert, Jean-Michel; Endl, Michael; Fabrycky, Daniel; Fressin, Francois; Haas, Michael; Horch, Elliott; Howard, Andrew; Isaacson, Howard; Kjeldsen, Hans; Kolodziejczak, Jeffery; Kulesa, Craig; Li, Jie; Lucas, Philip W.; Machalek, Pavel; McCarthy, Donald; MacQueen, Phillip; Meibom, Søren; Miquel, Thibaut; Prsa, Andrej; Quinn, Samuel N.; Quintana, Elisa V.; Ragozzine, Darin; Sherry, William; Shporer, Avi; Tenenbaum, Peter; Torres, Guillermo; Twicken, Joseph D.; Van Cleve, Jeffrey; Walkowicz, Lucianne; Witteborn, Fred C.; Still, Martin

2011-07-01

On 2011 February 1 the Kepler mission released data for 156,453 stars observed from the beginning of the science observations on 2009 May 2 through September 16. There are 1235 planetary candidates with transit-like signatures detected in this period. These are associated with 997 host stars. Distributions of the characteristics of the planetary candidates are separated into five class sizes: 68 candidates of approximately Earth-size (R p R ⊕), 288 super-Earth-size (1.25 R ⊕ R p R ⊕), 662 Neptune-size (2 R ⊕ R p R ⊕), 165 Jupiter-size (6 R ⊕ R p R ⊕), and 19 up to twice the size of Jupiter (15 R ⊕ R p R ⊕). In the temperature range appropriate for the habitable zone, 54 candidates are found with sizes ranging from Earth-size to larger than that of Jupiter. Six are less than twice the size of the Earth. Over 74% of the planetary candidates are smaller than Neptune. The observed number versus size distribution of planetary candidates increases to a peak at two to three times the Earth-size and then declines inversely proportional to the area of the candidate. Our current best estimates of the intrinsic frequencies of planetary candidates, after correcting for geometric and sensitivity biases, are 5% for Earth-size candidates, 8% for super-Earth-size candidates, 18% for Neptune-size candidates, 2% for Jupiter-size candidates, and 0.1% for very large candidates; a total of 0.34 candidates per star. Multi-candidate, transiting systems are frequent; 17% of the host stars have multi-candidate systems, and 34% of all the candidates are part of multi-candidate systems.

CHARACTERISTICS OF PLANETARY CANDIDATES OBSERVED BY KEPLER. II. ANALYSIS OF THE FIRST FOUR MONTHS OF DATA

International Nuclear Information System (INIS)

Borucki, William J.; Koch, David G.; Bryson, Stephen T.; Lissauer, Jack J.; Basri, Gibor; Marcy, Geoffrey W.; Batalha, Natalie; Brown, Timothy M.; Caldwell, Douglas; DeVore, Edna; Jenkins, Jon M.; Christensen-Dalsgaard, Joergen; Cochran, William D.; Dunham, Edward W.; Gautier, Thomas N.; Geary, John C.; Latham, David W.; Gilliland, Ronald; Gould, Alan; Howell, Steve B.

2011-01-01

On 2011 February 1 the Kepler mission released data for 156,453 stars observed from the beginning of the science observations on 2009 May 2 through September 16. There are 1235 planetary candidates with transit-like signatures detected in this period. These are associated with 997 host stars. Distributions of the characteristics of the planetary candidates are separated into five class sizes: 68 candidates of approximately Earth-size (R p + ), 288 super-Earth-size (1.25 R + ≤ R p + ), 662 Neptune-size (2 R + ≤ R p + ), 165 Jupiter-size (6 R + ≤ R p + ), and 19 up to twice the size of Jupiter (15 R + ≤ R p + ). In the temperature range appropriate for the habitable zone, 54 candidates are found with sizes ranging from Earth-size to larger than that of Jupiter. Six are less than twice the size of the Earth. Over 74% of the planetary candidates are smaller than Neptune. The observed number versus size distribution of planetary candidates increases to a peak at two to three times the Earth-size and then declines inversely proportional to the area of the candidate. Our current best estimates of the intrinsic frequencies of planetary candidates, after correcting for geometric and sensitivity biases, are 5% for Earth-size candidates, 8% for super-Earth-size candidates, 18% for Neptune-size candidates, 2% for Jupiter-size candidates, and 0.1% for very large candidates; a total of 0.34 candidates per star. Multi-candidate, transiting systems are frequent; 17% of the host stars have multi-candidate systems, and 34% of all the candidates are part of multi-candidate systems.

Construction of Basic Evaluation Criteria for Candidate HLW Repository Sites (1)

International Nuclear Information System (INIS)

Koh, Yong Kwon; Bae, Dae Seok; Kim, Kyung Su; Kim, Geon Young; Park, Kyung Woo; Ji, Sung Hoon; Ryu, Ji Hun

2009-08-01

We constructed the preliminary site assessment system for selection of proper site as high level radioactive disposal repository with consideration of Korean geological characteristics and underground environments. And, site assessment factor and standard as a point of geologic aspect were suggested for decision of candidate radioactive disposal site in Korea. The results can be used to develop the geological information system for assessment of candidate disposal site

Candidate Prediction Models and Methods

DEFF Research Database (Denmark)

Nielsen, Henrik Aalborg; Nielsen, Torben Skov; Madsen, Henrik

2005-01-01

This document lists candidate prediction models for Work Package 3 (WP3) of the PSO-project called ``Intelligent wind power prediction systems'' (FU4101). The main focus is on the models transforming numerical weather predictions into predictions of power production. The document also outlines...... the possibilities w.r.t. different numerical weather predictions actually available to the project....

Automated corresponding point candidate selection for image registration using wavelet transformation neurla network with rotation invariant inputs and context information about neighboring candidates

Science.gov (United States)

Okumura, Hiroshi; Suezaki, Masashi; Sueyasu, Hideki; Arai, Kohei

2003-03-01

An automated method that can select corresponding point candidates is developed. This method has the following three features: 1) employment of the RIN-net for corresponding point candidate selection; 2) employment of multi resolution analysis with Haar wavelet transformation for improvement of selection accuracy and noise tolerance; 3) employment of context information about corresponding point candidates for screening of selected candidates. Here, the 'RIN-net' means the back-propagation trained feed-forward 3-layer artificial neural network that feeds rotation invariants as input data. In our system, pseudo Zernike moments are employed as the rotation invariants. The RIN-net has N x N pixels field of view (FOV). Some experiments are conducted to evaluate corresponding point candidate selection capability of the proposed method by using various kinds of remotely sensed images. The experimental results show the proposed method achieves fewer training patterns, less training time, and higher selection accuracy than conventional method.

RED GIANTS IN ECLIPSING BINARY AND MULTIPLE-STAR SYSTEMS: MODELING AND ASTEROSEISMIC ANALYSIS OF 70 CANDIDATES FROM KEPLER DATA

International Nuclear Information System (INIS)

Gaulme, P.; McKeever, J.; Rawls, M. L.; Jackiewicz, J.; Mosser, B.; Guzik, J. A.

2013-01-01

Red giant stars are proving to be an incredible source of information for testing models of stellar evolution, as asteroseismology has opened up a window into their interiors. Such insights are a direct result of the unprecedented data from space missions CoRoT and Kepler as well as recent theoretical advances. Eclipsing binaries are also fundamental astrophysical objects, and when coupled with asteroseismology, binaries provide two independent methods to obtain masses and radii and exciting opportunities to develop highly constrained stellar models. The possibility of discovering pulsating red giants in eclipsing binary systems is therefore an important goal that could potentially offer very robust characterization of these systems. Until recently, only one case has been discovered with Kepler. We cross-correlate the detected red giant and eclipsing-binary catalogs from Kepler data to find possible candidate systems. Light-curve modeling and mean properties measured from asteroseismology are combined to yield specific measurements of periods, masses, radii, temperatures, eclipse timing variations, core rotation rates, and red giant evolutionary state. After using three different techniques to eliminate false positives, out of the 70 systems common to the red giant and eclipsing-binary catalogs we find 13 strong candidates (12 previously unknown) to be eclipsing binaries, one to be a non-eclipsing binary with tidally induced oscillations, and 10 more to be hierarchical triple systems, all of which include a pulsating red giant. The systems span a range of orbital eccentricities, periods, and spectral types F, G, K, and M for the companion of the red giant. One case even suggests an eclipsing binary composed of two red giant stars and another of a red giant with a δ-Scuti star. The discovery of multiple pulsating red giants in eclipsing binaries provides an exciting test bed for precise astrophysical modeling, and follow-up spectroscopic observations of many of the

A MULTIWAVELENGTH CHARACTERIZATION OF PROTO-BROWN-DWARF CANDIDATES IN SERPENS

Energy Technology Data Exchange (ETDEWEB)

Riaz, B.; Caselli, P. [Max-Planck-Institut für Extraterrestrische Physik, Giessenbachstrasse 1, D-85748 Garching (Germany); Vorobyov, E. [Institute of Astrophysics, University of Vienna, Vienna 1180 (Austria); Research Institute of Physics, Southern Federal University, Rostov-on-Don 344090 (Russian Federation); Harsono, D. [Universitt Heidelberg, Zentrum fr Astronomie, Institut für Theoretische Astrophysik, Albert-Ueberle-Str. 2, D-69120, Heidelberg (Germany); Tikare, K. [IRAP, BP 44346-31028 Toulouse Cedex 4 (France); Gonzalez-Martin, O., E-mail: briaz@mpe.mpg.de [Instituto de Radioastronoma y Astrofsica (IRyA), UNAM, Antigua Carretera a Pátzcuaro # 8701, Col. Ex Hacienda San José de la Huerta, Morelia, Michoacán, C.P. 58089 (Mexico)

2016-11-10

We present results from a deep submillimeter survey in the Serpens Main and Serpens/G3–G6 clusters, conducted with the Submillimetre Common-User Bolometer Array (SCUBA-2) at the James Clerk Maxwell Telescope. We have combined near- and mid-infrared spectroscopy, Herschel PACS far-infrared photometry, submillimeter continuum, and molecular gas line observations, with the aim of conducting a detailed multiwavelength characterization of “proto-brown-dwarf” (proto-BD) candidates in Serpens. We have performed continuum and line radiative transfer modeling and have considered various classification schemes to understand the structure and the evolutionary stage of the system. We have identified four proto-BD candidates, of which the lowest-luminosity source has an L {sub bol} ∼ 0.05 L {sub ☉}. Two of these candidates show characteristics consistent with Stage 0/I systems, while the other two are Stage I-T/Class Flat systems with tenuous envelopes. Our work has also revealed a ∼20% fraction of misidentified Class 0/I/Flat sources that show characteristics consistent with Class II edge-on disk systems. We have set constraints on the mass of the central object using the measured bolometric luminosities and numerical simulations of stellar evolution. Considering the available gas+dust mass reservoir and the current mass of the central source, three of these candidates are likely to evolve into BDs.

Candidal colonization, strain diversity, and antifungal susceptibility among adult diabetic patients.

Science.gov (United States)

Al-Attas, Safia A; Amro, Soliman O

2010-01-01

Candidal colonization in diabetics is a matter of debate. The aim of this study is to investigate oral candidal colonization, strain diversity, antifungal susceptibility, and the influence of local and systemic host factors on candidal colonization in adult diabetics. We conducted a case-control study that compared 150 diabetics (49 type 1, 101 type 2) with 50 healthy controls. Two salivary samples were collected, using the oral rinse sampling method: one for salivary flow rate and pH determination, and the other for candidal colonization assessment. The candidal isolates were identified and tested in vitro for antifungal susceptibility using the commercial kit, Candifast. The relationship between specific host factors and candidal colonization was also investigated. Diabetics had a higher candidal carriage rate compared to controls, but not density. Candida albicans was the most frequently isolated species, but diabetics had a variety of other candidal species present. None of the control samples were resistant to any tested antifungal, while the diabetic samples had differing resistances to azole antifungals. Although there was a significant positive correlation between glycemic control and candidal colonization in type 2 diabetics, there was a negative correlation between salivary pH and candidal carriage in the controls versus density in type 2 diabetics. Diabetic patients not only had a higher candidal carriage rate, but also a variety of candidal species that were resistant to azole antifungals. Oral candidal colonization was significantly associated with glycemic control, type of diabetes, and salivary pH.

Analysing supercritical water reactor's (SCWR's) special safety systems using probabilistic tools

International Nuclear Information System (INIS)

Ituen, I.; Novog, D.R.

2011-01-01

The next generation of reactors, termed Generation IV, has very attractive features -- its superior safety characteristics, high thermal efficiency, and fuel cycle sustainability. A key element of the Generation IV designs is the improvement in safety, which in turn requires improvements in safety system performance and reliability, as well as a reduction in initiating event frequencies. This study compares the response of the systems important to safety in the CANDU-Supercritical Water Reactor to those of the generic CANDU under a main steamline break accident and loss of forced circulation events -- to quantify the improvements in safety for the pre-conceptual CANDU SCWR design. Probabilistic safety analysis is the tool used in this study to test the behavior of the pre- conceptual design during these events. (author)

Performance of a Drift Chamber Candidate for a Cosmic Muon Tomography System

Energy Technology Data Exchange (ETDEWEB)

Anghel, V.; Jewett, C.; Jonkmans, G.; Thompson, M. [Atomic Energy of Canada Limited, Chalk River, Ontario (Canada); Armitage, J.; Botte, J.; Boudjemline, K.; Erlandson, A.; Oakham, G. [Ottawa-Carleton Institute for Physics, Department of Physics, Carleton University, Ottawa, Ontario (Canada); Bueno, J.; Bryman, D.; Liu, Z. [Advanced Applied Physics Solutions, Vancouver, British Columbia (Canada); Charles, E.; Gallant, G. [Canada Border Services Agency, Ottawa, Ontario (Canada); Cousins, T.; Noel, S. [International Safety Research, Ottawa, Ontario (Canada); Drouin, P.-L.; Waller, D. [Defence Research and Development Canada, Ottawa, Ontario (Canada); Stocki, T. J. [Health Canada, Ottawa, Ontario (Canada)

2011-12-13

In the last decade, many groups around the world have been exploring different ways to probe transport containers which may contain illicit Special Nuclear Materials such as uranium. The muon tomography technique has been proposed as a cost effective system with an acceptable accuracy. A group of Canadian institutions (see above), funded by Defence Research and Development Canada, is testing different technologies to track the cosmic muons. One candidate is the single wire Drift Chamber. With the capability of a 2D impact position measurement, two detectors will be placed above and two below the object to be probed. In order to achieve a good 3D image quality of the cargo content, a good angular resolution is required. The simulation showed that 1mrad was required implying the spatial resolution of the trackers must be in the range of 1 to 2 mm for 1 m separation. A tracking system using three prototypes has been built and tested. The spatial resolution obtained is 1.7 mm perpendicular to the wire and 3 mm along the wire.

Whole genome homology-based identification of candidate genes ...

African Journals Online (AJOL)

Josephine Erhiakporeh

2016-07-06

Jul 6, 2016 ... candidate genes for drought tolerance in sesame. (Sesamum ... Our results provided genomic resources for further functional analysis and genetic engineering .... reverse transcribed using the Reverse Transcription System.

Oriented regions grouping based candidate proposal for infrared pedestrian detection

Science.gov (United States)

Wang, Jiangtao; Zhang, Jingai; Li, Huaijiang

2018-04-01

Effectively and accurately locating the positions of pedestrian candidates in image is a key task for the infrared pedestrian detection system. In this work, a novel similarity measuring metric is designed. Based on the selective search scheme, the developed similarity measuring metric is utilized to yield the possible locations for pedestrian candidate. Besides this, corresponding diversification strategies are also provided according to the characteristics of the infrared thermal imaging system. Experimental results indicate that the presented scheme can achieve more efficient outputs than the traditional selective search methodology for the infrared pedestrian detection task.

Far-Infrared Based Pedestrian Detection for Driver-Assistance Systems Based on Candidate Filters, Gradient-Based Feature and Multi-Frame Approval Matching.

Science.gov (United States)

Wang, Guohua; Liu, Qiong

2015-12-21

Far-infrared pedestrian detection approaches for advanced driver-assistance systems based on high-dimensional features fail to simultaneously achieve robust and real-time detection. We propose a robust and real-time pedestrian detection system characterized by novel candidate filters, novel pedestrian features and multi-frame approval matching in a coarse-to-fine fashion. Firstly, we design two filters based on the pedestrians' head and the road to select the candidates after applying a pedestrian segmentation algorithm to reduce false alarms. Secondly, we propose a novel feature encapsulating both the relationship of oriented gradient distribution and the code of oriented gradient to deal with the enormous variance in pedestrians' size and appearance. Thirdly, we introduce a multi-frame approval matching approach utilizing the spatiotemporal continuity of pedestrians to increase the detection rate. Large-scale experiments indicate that the system works in real time and the accuracy has improved about 9% compared with approaches based on high-dimensional features only.

Far-Infrared Based Pedestrian Detection for Driver-Assistance Systems Based on Candidate Filters, Gradient-Based Feature and Multi-Frame Approval Matching

Directory of Open Access Journals (Sweden)

Guohua Wang

2015-12-01

Full Text Available Far-infrared pedestrian detection approaches for advanced driver-assistance systems based on high-dimensional features fail to simultaneously achieve robust and real-time detection. We propose a robust and real-time pedestrian detection system characterized by novel candidate filters, novel pedestrian features and multi-frame approval matching in a coarse-to-fine fashion. Firstly, we design two filters based on the pedestrians’ head and the road to select the candidates after applying a pedestrian segmentation algorithm to reduce false alarms. Secondly, we propose a novel feature encapsulating both the relationship of oriented gradient distribution and the code of oriented gradient to deal with the enormous variance in pedestrians’ size and appearance. Thirdly, we introduce a multi-frame approval matching approach utilizing the spatiotemporal continuity of pedestrians to increase the detection rate. Large-scale experiments indicate that the system works in real time and the accuracy has improved about 9% compared with approaches based on high-dimensional features only.

Environmental Systems Research Candidates Program--FY2000 Annual report

Energy Technology Data Exchange (ETDEWEB)

Piet, Steven James

2001-01-01

The Environmental Systems Research Candidates (ESRC) Program, which is scheduled to end September 2001, was established in April 2000 as part of the Environmental Systems Research and Analysis Program at the Idaho National Engineering and Environmental Laboratory (INEEL) to provide key science and technology to meet the clean-up mission of the U.S. Department of Energy Office of Environmental Management, and perform research and development that will help solve current legacy problems and enhance the INEEL’s scientific and technical capability for solving longer-term challenges. This report documents the progress and accomplishments of the ESRC Program from April through September 2000. The ESRC Program consists of 24 tasks subdivided within four research areas: A. Environmental Characterization Science and Technology. This research explores new data acquisition, processing, and interpretation methods that support cleanup and long-term stewardship decisions. B. Subsurface Understanding. This research expands understanding of the biology, chemistry, physics, hydrology, and geology needed to improve models of contamination problems in the earth’s subsurface. C. Environmental Computational Modeling. This research develops INEEL computing capability for modeling subsurface contaminants and contaminated facilities. D. Environmental Systems Science and Technology. This research explores novel processes to treat waste and decontaminate facilities. Our accomplishments during FY 2000 include the following: • We determined, through analysis of samples taken in and around the INEEL site, that mercury emissions from the INEEL calciner have not raised regional off-INEEL mercury contamination levels above normal background. • We have initially demonstrated the use of x-ray fluorescence to image uranium and heavy metal concentrations in soil samples. • We increased our understanding of the subsurface environment; applying mathematical complexity theory to the problem of

Optimization of Candidate Selection Using Naive Bayes: Case Study in Company X

Science.gov (United States)

Kadar, JA; Agustono, D.; Napitupulu, D.

2018-01-01

This research was conducted as a decision-making system, and an alternative solution to complete the candidate assessment for a particular position. The human resources (HR) section on company X is responsible and initiative in selecting candidates in accordance with the assessment of their superiors. Selection by using the method of filling out the manager’s assessment questionnaire on the candidate’s subordinate. Three (3) managers have been determined to assess the 11 candidates for subordinates. By using questionnaire of quality classification of human resources and formula naive bayes it will get result which finally grouped using criteria scale as final grouping. The HR department has also determined that what is received is that which meets criteria 5. The result is three (3) candidates who can be proposed as candidates for certain positions in company X, and have met all required calculations. Furthermore the candidate will be given to management as an alternative input data in the selection of candidates.

Optimized candidal biofilm microtiter assay

NARCIS (Netherlands)

Krom, Bastiaan P.; Cohen, Jesse B.; Feser, Gail E. McElhaney; Cihlar, Ronald L.

Microtiter based candidal biofilm formation is commonly being used. Here we describe the analysis of factors influencing the development of candidal biofilms such as the coating with serum, growth medium and pH. The data reported here show that optimal candidal biofilm formation is obtained when

Silo Storage Preconceptual Design

Energy Technology Data Exchange (ETDEWEB)

Stephanie L. Austad; Patrick W. Bragassa; Kevin M Croft; David S Ferguson; Scott C Gladson; Annette L Shafer; John H Weathersby

2012-09-01

The National Nuclear Security Administration (NNSA) has a need to develop and field a low-cost option for the long-term storage of a variety of radiological material. The storage option’s primary requirement is to provide both environmental and physical protection of the materials. Design criteria for this effort require a low initial cost and minimum maintenance over a 50-year design life. In 1999, Argonne National Laboratory-West was tasked with developing a dry silo storage option for the BN-350 Spent Fuel in Aktau Kazakhstan. Argon’s design consisted of a carbon steel cylinder approximately 16 ft long, 18 in. outside diameter and 0.375 in. wall thickness. The carbon steel silo was protected from corrosion by a duplex coating system consisting of zinc and epoxy. Although the study indicated that the duplex coating design would provide a design life well in excess of the required 50 years, the review board was concerned because of the novelty of the design and the lack of historical use. In 2012, NNSA tasked Idaho National Laboratory (INL) with reinvestigating the silo storage concept and development of alternative corrosion protection strategies. The 2012 study, “Silo Storage Concepts, Cathodic Protection Options Study” (INL/EST-12-26627), concludes that the option which best fits the design criterion is a passive cathotic protection scheme, consisting of a carbon steel tube coated with zinc or a zinc-aluminum alloy encapsulated in either concrete or a cement grout. The hot dipped zinc coating option was considered most efficient, but the flame-sprayed option could be used if a thicker zinc coating was determined to be necessary.

Coupled geomechanical/hydrological modeling: an overview of basalt waste isolation project studies

International Nuclear Information System (INIS)

Baca, R.G.; Case, J.B.; Patricio, J.G.

1980-07-01

Basalt Waste Isolation Project investigations of the Columbia River basalts are multi-disciplinary in nature with a broad scope spanning such areas as geology, seismology, geochemistry, hydrology, rock mechanics, and many other disciplines as well. In this paper, an overview is presented which surveys recent work on numerical modeling of geomechanical and hydrological processes in a basalt rock environment. A major objective of the ongoing numerical modeling work is to establish a predictive technology base with which to: interpret the interrelationships between geomechanical behavior of rock media, the natural hydrologic phenomena, and repository conditions; evaluate the effectiveness of preconceptual repository designs and assist in the design of in situ field testing; and assess the waste isolation capability of candidate host rocks within the Columbia River basalts. To accomplish this objective, a systems approach has been adopted which is based on the use of digital simulation models

Issue-Advocacy versus Candidate Advertising: Effects on Candidate Preferences and Democratic Process.

Science.gov (United States)

Pfau, Michael; Holbert, R. Lance; Szabo, Erin Alison; Kaminski, Kelly

2002-01-01

Examines the influence of soft-money-sponsored issue-advocacy advertising in U.S. House and Senate campaigns, comparing its effects against candidate-sponsored positive advertising and contrast advertising on viewers' candidate preferences and on their attitude that reflect democratic values. Reveals no main effects for advertising approach on…

Characterization of Gene Candidates for Vacuolar Sodium Transport from Hordeum Vulgare

KAUST Repository

Scheu, Arne Hagen August

2017-05-01

Soil salinity is a major abiotic stress for land plants, and multiple mechanisms of salt tolerance have evolved. Tissue tolerance is one of these mechanisms, which involves the sequestration of sodium into the vacuole to retain low cytosolic sodium concentrations. This enables the plant to maintain cellular functions, and ultimately maintain growth and yield. However, the molecular components involved in tissue tolerance remain elusive. Several candidate genes for vacuolar sodium sequestration have recently been identified by proteome analysis of vacuolar membranes purified from the salt-tolerant cereal Hordeum vulgare (barley). In this study, I aimed to characterize these candidates in more detail. I successfully cloned coding sequences for the majority of candidate genes with primers designed based on the barley reference genome sequence. During the course of this study a newer genome sequence with improved annotations was published, to which I also compared my observations. To study the candidate genes, I used the heterologous expression system Saccharomyces cerevisiae (yeast). I used several salt sensitive yeast strains (deficient in intrinsic sodium transporters) to test whether the candidate genes would affect their salt tolerance by mediating the sequestration of sodium into the yeast vacuole. I observed a reduction in growth upon expression for several of the gene candidate under salt-stress conditions. However, confocal microscopy suggests that most gene products are subject to degradation, and did not localize to the vacuolar membrane (tonoplast). Therefore, growth effects cannot be linked to protein function without further evidence. Various potential causes are discussed, including inaccuracies in the genome resource used as reference for primer design and issues inherent to the model system. Finally, I make suggestions on how to proceed to further characterize the candidate genes and hopefully identify novel sodium transporters from barley.

A Large Size Chimeric Highly Immunogenic Peptide Presents Multistage Plasmodium Antigens as a Vaccine Candidate System against Malaria.

Science.gov (United States)

Lozano, José Manuel; Varela, Yahson; Silva, Yolanda; Ardila, Karen; Forero, Martha; Guasca, Laura; Guerrero, Yuly; Bermudez, Adriana; Alba, Patricia; Vanegas, Magnolia; Patarroyo, Manuel Elkin

2017-11-01

Rational strategies for obtaining malaria vaccine candidates should include not only a proper selection of target antigens for antibody stimulation, but also a versatile molecular design based on ordering the right pieces from the complex pathogen molecular puzzle towards more active and functional immunogens. Classical Plasmodium falciparum antigens regarded as vaccine candidates have been selected as model targets in this study. Among all possibilities we have chosen epitopes of Pf CSP, STARP; MSA1 and Pf 155/RESA from pre- and erythrocyte stages respectively for designing a large 82-residue chimeric immunogen. A number of options aimed at diminishing steric hindrance for synthetic procedures were assessed based on standard Fmoc chemistry such as building block orthogonal ligation; pseudo-proline and microwave-assisted procedures, therefore the large-chimeric target was produced, characterized and immunologically tested. Antigenicity and functional in vivo efficacy tests of the large-chimera formulations administered alone or as antigen mixtures have proven the stimulation of high antibody titers, showing strong correlation with protection and parasite clearance of vaccinated BALB/c mice after being lethally challenged with both P. berghei -ANKA and P. yoelii 17XL malaria strains. Besides, 3D structure features shown by the large-chimera encouraged as to propose using these rational designed large synthetic molecules as reliable vaccine candidate-presenting systems.

A Large Size Chimeric Highly Immunogenic Peptide Presents Multistage Plasmodium Antigens as a Vaccine Candidate System against Malaria

Directory of Open Access Journals (Sweden)

José Manuel Lozano

2017-11-01

Full Text Available Rational strategies for obtaining malaria vaccine candidates should include not only a proper selection of target antigens for antibody stimulation, but also a versatile molecular design based on ordering the right pieces from the complex pathogen molecular puzzle towards more active and functional immunogens. Classical Plasmodium falciparum antigens regarded as vaccine candidates have been selected as model targets in this study. Among all possibilities we have chosen epitopes of PfCSP, STARP; MSA1 and Pf155/RESA from pre- and erythrocyte stages respectively for designing a large 82-residue chimeric immunogen. A number of options aimed at diminishing steric hindrance for synthetic procedures were assessed based on standard Fmoc chemistry such as building block orthogonal ligation; pseudo-proline and microwave-assisted procedures, therefore the large-chimeric target was produced, characterized and immunologically tested. Antigenicity and functional in vivo efficacy tests of the large-chimera formulations administered alone or as antigen mixtures have proven the stimulation of high antibody titers, showing strong correlation with protection and parasite clearance of vaccinated BALB/c mice after being lethally challenged with both P. berghei-ANKA and P. yoelii 17XL malaria strains. Besides, 3D structure features shown by the large-chimera encouraged as to propose using these rational designed large synthetic molecules as reliable vaccine candidate-presenting systems.

FASTER Test Reactor Preconceptual Design Report

Energy Technology Data Exchange (ETDEWEB)

Grandy, C. [Argonne National Lab. (ANL), Argonne, IL (United States); Belch, H. [Argonne National Lab. (ANL), Argonne, IL (United States); Brunett, A. J. [Argonne National Lab. (ANL), Argonne, IL (United States); Heidet, F. [Argonne National Lab. (ANL), Argonne, IL (United States); Hill, R. [Argonne National Lab. (ANL), Argonne, IL (United States); Hoffman, E. [Argonne National Lab. (ANL), Argonne, IL (United States); Jin, E. [Argonne National Lab. (ANL), Argonne, IL (United States); Mohamed, W. [Argonne National Lab. (ANL), Argonne, IL (United States); Moisseytsev, A. [Argonne National Lab. (ANL), Argonne, IL (United States); Passerini, S. [Argonne National Lab. (ANL), Argonne, IL (United States); Sienicki, J. [Argonne National Lab. (ANL), Argonne, IL (United States); Sumner, T. [Argonne National Lab. (ANL), Argonne, IL (United States); Vilim, R. [Argonne National Lab. (ANL), Argonne, IL (United States); Hayes, S. [Argonne National Lab. (ANL), Argonne, IL (United States)

2016-03-31

The FASTER test reactor plant is a sodium-cooled fast spectrum test reactor that provides high levels of fast and thermal neutron flux for scientific research and development. The 120MWe FASTER reactor plant has a superheated steam power conversion system which provides electrical power to a local grid allowing for recovery of operating costs for the reactor plant.

Viral induced oxidative and inflammatory response in Alzheimer's disease pathogenesis with identification of potential drug candidates: A systematic review using systems biology approach.

Science.gov (United States)

Talwar, Puneet; Gupta, Renu; Kushwaha, Suman; Agarwal, Rachna; Saso, Luciano; Kukreti, Shrikant; Kukreti, Ritushree

2018-04-19

Alzheimer's disease (AD) is genetically complex with multifactorial etiology. Here, we aim to identify the potential viral pathogens leading to aberrant inflammatory and oxidative stress response in AD along with potential drug candidates using systems biology approach. We retrieved protein interactions of amyloid precursor protein (APP) and tau protein (MAPT) from NCBI and genes for oxidative stress from NetAge, for inflammation from NetAge and InnateDB databases. Genes implicated in aging were retrieved from GenAge database and two GEO expression datasets. These genes were individually used to create protein-protein interaction network using STRING database (score≥0.7). The interactions of candidate genes with known viruses were mapped using virhostnet v2.0 database. Drug molecules targeting candidate genes were retrieved using the Drug-Gene Interaction Database (DGIdb). Data mining resulted in 2095 APP, 116 MAPT, 214 oxidative stress, 1269 inflammatory genes. After STRING PPIN analysis, 404 APP, 109 MAPT, 204 oxidative stress and 1014 inflammation related high confidence proteins were identified. The overlap among all datasets yielded eight common markers (AKT1, GSK3B, APP, APOE, EGFR, PIN1, CASP8 and SNCA). These genes showed association with hepatitis C virus (HCV), Epstein-Barr virus (EBV), human herpes virus 8 and Human papillomavirus (HPV). Further, screening of drugs targeting candidate genes, and possessing anti-inflammatory property, antiviral activity along with suggested role in AD pathophysiology yielded 12 potential drug candidates. Our study demonstrated the role of viral etiology in AD pathogenesis by elucidating interaction of oxidative stress and inflammation causing candidate genes with common viruses along with the identification of potential AD drug candidates. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Planet hunters. VI. An independent characterization of KOI-351 and several long period planet candidates from the Kepler archival data

International Nuclear Information System (INIS)

Schmitt, Joseph R.; Wang, Ji; Fischer, Debra A.; Moriarty, John C.; Boyajian, Tabetha S.; Jek, Kian J.; LaCourse, Daryll; Omohundro, Mark R.; Winarski, Troy; Goodman, Samuel Jon; Jebson, Tony; Schwengeler, Hans Martin; Paterson, David A.; Schwamb, Megan E.; Lintott, Chris; Simpson, Robert; Lynn, Stuart; Smith, Arfon M.; Parrish, Michael; Schawinski, Kevin

2014-01-01

We report the discovery of 14 new transiting planet candidates in the Kepler field from the Planet Hunters citizen science program. None of these candidates overlapped with Kepler Objects of Interest (KOIs) at the time of submission. We report the discovery of one more addition to the six planet candidate system around KOI-351, making it the only seven planet candidate system from Kepler. Additionally, KOI-351 bears some resemblance to our own solar system, with the inner five planets ranging from Earth to mini-Neptune radii and the outer planets being gas giants; however, this system is very compact, with all seven planet candidates orbiting ≲ 1 AU from their host star. A Hill stability test and an orbital integration of the system shows that the system is stable. Furthermore, we significantly add to the population of long period transiting planets; periods range from 124 to 904 days, eight of them more than one Earth year long. Seven of these 14 candidates reside in their host star's habitable zone.

ENU Mutagenesis in Mice Identifies Candidate Genes For Hypogonadism

Science.gov (United States)

Weiss, Jeffrey; Hurley, Lisa A.; Harris, Rebecca M.; Finlayson, Courtney; Tong, Minghan; Fisher, Lisa A.; Moran, Jennifer L.; Beier, David R.; Mason, Christopher; Jameson, J. Larry

2012-01-01

Genome-wide mutagenesis was performed in mice to identify candidate genes for male infertility, for which the predominant causes remain idiopathic. Mice were mutagenized using N-ethyl-N-nitrosourea (ENU), bred, and screened for phenotypes associated with the male urogenital system. Fifteen heritable lines were isolated and chromosomal loci were assigned using low density genome-wide SNP arrays. Ten of the fifteen lines were pursued further using higher resolution SNP analysis to narrow the candidate gene regions. Exon sequencing of candidate genes identified mutations in mice with cystic kidneys (Bicc1), cryptorchidism (Rxfp2), restricted germ cell deficiency (Plk4), and severe germ cell deficiency (Prdm9). In two other lines with severe hypogonadism candidate sequencing failed to identify mutations, suggesting defects in genes with previously undocumented roles in gonadal function. These genomic intervals were sequenced in their entirety and a candidate mutation was identified in SnrpE in one of the two lines. The line harboring the SnrpE variant retains substantial spermatogenesis despite small testis size, an unusual phenotype. In addition to the reproductive defects, heritable phenotypes were observed in mice with ataxia (Myo5a), tremors (Pmp22), growth retardation (unknown gene), and hydrocephalus (unknown gene). These results demonstrate that the ENU screen is an effective tool for identifying potential causes of male infertility. PMID:22258617

ECRH/EBWH system for NSTX-U

Directory of Open Access Journals (Sweden)

Hosea J.C.

2012-09-01

Full Text Available The National Spherical Torus Experiment Upgrade (NSTX-U will operate at an axial toroidal field of up to 1 T, about twice the field available on NSTX. A 28 GHz electron cylotron resonance heating (ECRH system is currently being planned for NSTX-U. A 1 MW 28 GHz gyrotron will be employed. Intially the system will use short, 10-50 ms, 1 MW pulses for ECRH-assisted discharge start-up. Later the pulse length will be extended to 1-5 s to study electron Bernstein wave heating (EBWH during the plasma current flat top. A mirror launcher will be used to couple microwave power to the plasma via O-mode to the slow X-mode to EBW (O-X-B double mode conversion. This paper presents a pre-conceptual design for the ECRH/EBWH system proposed for NSTX-U and includes ray tracing and Fokker-Planck modeling results for 28 GHz ECRH during plasma start-up and EBW heating and current drive during the plasma current flattop of a NSTX-U advanced H-mode plasma scenario.

Teacher Candidates in Context: Investigating Inquiry Learning, Self-Efficacy and Stress within Teacher Education

OpenAIRE

Coppersmith, Sarah A.

2017-01-01

Global changes since the 2008 economic collapse continue to impact teacher candidates worldwide who are facing unparalleled challenges as they prepare for service in educational systems experiencing reform. Research exists on college student stress, yet absent is data showing teacher candidates in relation to stress and self-efficacy as they engage in socio-constructivist inquiry learning. Teacher candidates hold employment while taking classes and serving in schools, yet research shows that ...

Technical evaluation of major candidate blanket systems for fusion power reactor

International Nuclear Information System (INIS)

Tone, Tatsuzo; Seki, Masahiro; Minato, Akio

1987-03-01

The key functions required for tritium breeding blankets for a fusion power reactor are: (1) self-sufficient tritium breeding, (2) in-situ tritium recovery and low tritium inventory, (3) high temperature cooling giving a high efficiency of electricity generation and (4) thermo-mechanical reliability and simplified remote maintenance to obtain high plant availability. Blanket performance is substantially governed by materials selection. Major options of structure/breeder/coolant/neutron multiplier materials considered for the present design study are PCA/Li 2 O/H 2 O/Be, Mo-alloy/Li 2 O/He/Be, Mo-alloy/LiAlO 2 /He/Be, V-alloy/Li/Li/none, and Mo-alloy/Li/He/none. In addition, remote maintenance of blankets, tritium recovery system, heat transport and energy conversion have been investigated. In this report, technological problems and critical R and D issues for power reactor blanket development are identified and a comparison of major candidate blanket concepts is discussed in terms of the present materials data base, economic performance, prospects for future improvements, and engineering feasibility and difficulties based on the results obtained from individual design studies. (author)

Geoscience Training for NASA Astronaut Candidates

Science.gov (United States)

Young, K. E.; Evans, C. A.; Bleacher, J. E.; Graff, T. G.; Zeigler, R.

2017-01-01

After being selected to the astronaut office, crewmembers go through an initial two year training flow, astronaut candidacy, where they learn the basic skills necessary for spaceflight. While the bulk of astronaut candidate training currently centers on the multiple subjects required for ISS operations (EVA skills, Russian language, ISS systems, etc.), training also includes geoscience training designed to train crewmembers in Earth observations, teach astronauts about other planetary systems, and provide field training designed to investigate field operations and boost team skills. This training goes back to Apollo training and has evolved to support ISS operations and future exploration missions.

11 CFR 100.154 - Candidate debates.

Science.gov (United States)

2010-01-01

... 11 Federal Elections 1 2010-01-01 2010-01-01 false Candidate debates. 100.154 Section 100.154 Federal Elections FEDERAL ELECTION COMMISSION GENERAL SCOPE AND DEFINITIONS (2 U.S.C. 431) Exceptions to Expenditures § 100.154 Candidate debates. Funds used to defray costs incurred in staging candidate debates in...

11 CFR 100.92 - Candidate debates.

Science.gov (United States)

2010-01-01

... 11 Federal Elections 1 2010-01-01 2010-01-01 false Candidate debates. 100.92 Section 100.92 Federal Elections FEDERAL ELECTION COMMISSION GENERAL SCOPE AND DEFINITIONS (2 U.S.C. 431) Exceptions to Contributions § 100.92 Candidate debates. Funds provided to defray costs incurred in staging candidate debates...

Advanced High Temperature Reactor Systems and Economic Analysis

Energy Technology Data Exchange (ETDEWEB)

Holcomb, David Eugene [ORNL; Peretz, Fred J [ORNL; Qualls, A L [ORNL

2011-09-01

with advanced supercritical-water power cycles. The current design activities build upon a series of small-scale efforts over the past decade to evaluate and describe the features and technology variants of FHRs. Key prior concept evaluation reports include the SmAHTR preconceptual design report,1 the PB-AHTR preconceptual design, and the series of early phase AHTR evaluations performed from 2004 to 2006. This report provides a power plant-focused description of the current state of the AHTR. The report includes descriptions and sizes of the major heat transport and power generation components. Component configuration and sizing are based upon early phase AHTR plant thermal hydraulic models. The report also provides a top-down AHTR comparative economic analysis. A commercially available advanced supercritical water-based power cycle was selected as the baseline AHTR power generation cycle both due to its superior performance and to enable more realistic economic analysis. The AHTR system design, however, has several remaining gaps, and the plant cost estimates consequently have substantial remaining uncertainty. For example, the enriched lithium required for the primary coolant cannot currently be produced on the required scale at reasonable cost, and the necessary core structural ceramics do not currently exist in a nuclear power qualified form. The report begins with an overview of the current, early phase, design of the AHTR plant. Only a limited amount of information is included about the core and vessel as the core design and refueling options are the subject of a companion report. The general layout of an AHTR system and site showing the relationship of the major facilities is then provided. Next is a comparative evaluation of the AHTR anticipated performance and costs. Finally, the major system design efforts necessary to bring the AHTR design to a pre-conceptual level are then presented.

TFCX pumped limiter and vacuum pumping system design and analysis

International Nuclear Information System (INIS)

Haines, J.R.

1985-04-01

Impurity control system design and performance studies were performed in support of the Tokamak Fusion Core Experiment (TFCX) pre-conceptual design. Efforts concentrated on pumped limiter and vacuum pumping system design configuration, thermal/mechanical and erosion lifetime performance of the limiter protective surface, and helium ash removal performance. The reference limiter design forms a continuous toroidal belt at the bottom of the device and features a flat surface with a single leading edge. The vacuum pumping system features large vacuum ducts (diameter approximately 1 m) and high-speed, compound cryopumps. Analysis results indicate that the limiter/vacuum pumping system design provides adequate helium ash removal. Erosion, primarily by disruption-induced vaporization and/or melting, limits the protective surface lifetime to about one calendar year or only about 60 full-power hours of operation. In addition to evaluating impurity control system performance for nominal TFCX conditions, these studies attempt to focus on the key plasma physics and engineering design issues that should be addressed in future research and development programs

The Gaia-ESO Survey: double-, triple-, and quadruple-line spectroscopic binary candidates

Science.gov (United States)

Merle, T.; Van Eck, S.; Jorissen, A.; Van der Swaelmen, M.; Masseron, T.; Zwitter, T.; Hatzidimitriou, D.; Klutsch, A.; Pourbaix, D.; Blomme, R.; Worley, C. C.; Sacco, G.; Lewis, J.; Abia, C.; Traven, G.; Sordo, R.; Bragaglia, A.; Smiljanic, R.; Pancino, E.; Damiani, F.; Hourihane, A.; Gilmore, G.; Randich, S.; Koposov, S.; Casey, A.; Morbidelli, L.; Franciosini, E.; Magrini, L.; Jofre, P.; Costado, M. T.; Jeffries, R. D.; Bergemann, M.; Lanzafame, A. C.; Bayo, A.; Carraro, G.; Flaccomio, E.; Monaco, L.; Zaggia, S.

2017-12-01

Context. The Gaia-ESO Survey (GES) is a large spectroscopic survey that provides a unique opportunity to study the distribution of spectroscopic multiple systems among different populations of the Galaxy. Aims: Our aim is to detect binarity/multiplicity for stars targeted by the GES from the analysis of the cross-correlation functions (CCFs) of the GES spectra with spectral templates. Methods: We developed a method based on the computation of the CCF successive derivatives to detect multiple peaks and determine their radial velocities, even when the peaks are strongly blended. The parameters of the detection of extrema (DOE) code have been optimized for each GES GIRAFFE and UVES setup to maximize detection. The DOE code therefore allows to automatically detect multiple line spectroscopic binaries (SBn, n ≥ 2). Results: We apply this method on the fourth GES internal data release and detect 354 SBn candidates (342 SB2, 11 SB3, and even one SB4), including only nine SBs known in the literature. This implies that about 98% of these SBn candidates are new because of their faint visual magnitude that can reach V = 19. Visual inspection of the SBn candidate spectra reveals that the most probable candidates have indeed a composite spectrum. Among the SB2 candidates, an orbital solution could be computed for two previously unknown binaries: CNAME 06404608+0949173 (known as V642 Mon) in NGC 2264 and CNAME 19013257-0027338 in Berkeley 81 (Be 81). A detailed analysis of the unique SB4 (four peaks in the CCF) reveals that CNAME 08414659-5303449 (HD 74438) in the open cluster IC 2391 is a physically bound stellar quadruple system. The SB candidates belonging to stellar clusters are reviewed in detail to discard false detections. We suggest that atmospheric parameters should not be used for these system components; SB-specific pipelines should be used instead. Conclusions: Our implementation of an automatic detection of spectroscopic binaries within the GES has allowed the

Systems for Nuclear Auxiliary Power annual report, government fiscal year 1976/TQ

International Nuclear Information System (INIS)

1976-01-01

The overall objective of the Systems for Nuclear Auxiliary Power (SNAP) Program is to continue system and component engineering activities relating to the zirconium hydride (ZrH) reactor. The specific objectives for FY 1976/TQ were to: (1) study standardized ZrH reactor space power systems and components, (2) perform preconceptual analysis and design of ZrH reactor--organic Rankine power systems for subsea applications, (3) conduct fuel and hydrogen barrier investigations, (4) perform system studies in support of the Department of Defense and their contractors as directed by ERDA, (5) test components, and (6) provide for material disposal and facility surveillance. In the study, representative systems which utilize Brayton, Rankine, and Stirling cycle power conversion units as well as thermoelectric modules, are analyzed at power levels of 10, 25, 50, and 75 kWe. Waste heat rejection is accomplished by concentric, cylindrical space radiators which can be nested during launch for space shuttle integration. Subsequent studies, which supported this effort, were completed and provided useful information on system reliability and survivability

Spectroscopic follow up of Kepler planet candidates

DEFF Research Database (Denmark)

Latham..[], D. W.; Cochran, W. D.; Marcy, G.W.

2010-01-01

Spectroscopic follow-up observations play a crucial role in the confirmation and characterization of transiting planet candidates identified by Kepler. The most challenging part of this work is the determination of radial velocities with a precision approaching 1 m/s in order to derive masses from...... spectroscopic orbits. The most precious resource for this work is HIRES on Keck I, to be joined by HARPS-North on the William Herschel Telescope when that new spectrometer comes on line in two years. Because a large fraction of the planet candidates are in fact stellar systems involving eclipsing stars...... and not planets, our strategy is to start with reconnaissance spectroscopy using smaller telescopes, to sort out and reject as many of the false positives as possible before going to Keck. During the first Kepler observing season in 2009, more than 100 nights of telescope time were allocated for this work, using...

Systematic Identification of Intracellular-Translocated Candidate Effectors in Edwardsiella piscicida

Directory of Open Access Journals (Sweden)

Lingzhi Zhang

2018-02-01

Full Text Available Many bacterial pathogens inject effectors directly into host cells to target a variety of host cellular processes and promote bacterial dissemination and survival. Identifying the bacterial effectors and elucidating their functions are central to understanding the molecular pathogenesis of these pathogens. Edwardsiella piscicida is a pathogen with a wide host range, and very few of its effectors have been identified to date. Here, based on the genes significantly regulated by macrophage infection, we identified 25 intracellular translocation-positive candidate effectors, including all five previously reported effectors, namely EseG, EseJ, EseH, EseK, and EvpP. A subsequent secretion analysis revealed diverse secretion patterns for the 25 effector candidates, suggesting that multiple transport pathways were involved in the internalization of these candidate effectors. Further, we identified two novel type VI secretion system (T6SS putative effectors and three outer membrane vesicles (OMV-dependent putative effectors among the candidate effectors described above, and further analyzed their contribution to bacterial virulence in a zebrafish model. This work demonstrates an effective approach for screening bacterial effectors and expands the effectors repertoire in E. piscicida.

An Assessment of Technical and Production Risks of Candidate Low-Cost Attitude/Heading Reference Systems(AHRS)

Science.gov (United States)

Yuchnovicz, Daniel; Burgess, Malcolm; Hammers, William

1999-01-01

This report provides an assessment of technical and production risks of candidate low-cost attitude/heading reference systems (AHRS) for use in the Advanced General Aviation Transport Experiments (AGATE) airplanes. A low-cost AHRS is a key component of modem "glass cockpit" flight displays for General Aviation (GA) aircraft. The technical capabilities of several candidate low-cost AHRS were examined and described along with the technical issues involved with using all solid-state components for attitude measurement. An economic model was developed which describes the expected profit, rate of return, and volume requirements for the manufacture of low-cost AHRS for GA aircraft in the 2000 to 2020 time frame. The model is the result of interviews with GA airframe manufacturers, avionics manufacturers and historical analysis of avionics of similar complexity. The model shows that a manufacturer will break even after three years of AHRS production, realizing an 18 percent rate of return (23 percent profit) on an investment of $3.5M over the 20 year period. A start-up production estimate showed costs of $6-12M for a new company to build and certify an AHRS from scratch, considered to be a high-risk proposition, versus $0.25-0.75M for an experienced avionics manufacturer to manufacture a design under license, a low-risk proposition.

Design characteristics of pantograph type in vessel fuel handling system in SFR

International Nuclear Information System (INIS)

Kim, S. H.; Koo, G. H.

2012-01-01

The pantograph type in vessel fuel handling system in a sodium cooled fast reactor (SFR), which requires installation space for the slot in the upper internal structure attached under the rotating plug, is composed of an in vessel transfer machine (IVTM), a single rotating plug, in vessel storage, and a fuel transfer port (FTP). The pantograph type IVTM can exchange fuel assemblies through a slot, the design requirement of which should be essentially considered in the design of the in vessel fuel handling system. In addition, the spent fuel assemblies temporarily stored in the in vessel storage of the reactor vessel are removed to the outside of the reactor vessel through the FTP. The fuel transfer basket is then provided in the FTP, and a fuel transfer is performed by using it. In this study, the design characteristics for a pantograph type in vessel fuel handling system are reviewed, and the preconceptual designs are studied

Design characteristics of pantograph type in vessel fuel handling system in SFR

Energy Technology Data Exchange (ETDEWEB)

Kim, S. H.; Koo, G. H. [KAERI, Daejeon (Korea, Republic of)

2012-10-15

The pantograph type in vessel fuel handling system in a sodium cooled fast reactor (SFR), which requires installation space for the slot in the upper internal structure attached under the rotating plug, is composed of an in vessel transfer machine (IVTM), a single rotating plug, in vessel storage, and a fuel transfer port (FTP). The pantograph type IVTM can exchange fuel assemblies through a slot, the design requirement of which should be essentially considered in the design of the in vessel fuel handling system. In addition, the spent fuel assemblies temporarily stored in the in vessel storage of the reactor vessel are removed to the outside of the reactor vessel through the FTP. The fuel transfer basket is then provided in the FTP, and a fuel transfer is performed by using it. In this study, the design characteristics for a pantograph type in vessel fuel handling system are reviewed, and the preconceptual designs are studied.

Criteria for candidate species for aquaculture

Energy Technology Data Exchange (ETDEWEB)

Webber, H H; Riordan, P F

1976-01-01

The nature of the animal taxa that are the most probable candidates for an intensive, commercial aquatic animal husbandry industry is considered. A characterization is presented of those biological criteria that lend the species the necessary physiological and genetic malleability to be adapted and molded into a domesticated race. The animal cultivated must be amenable to intensive management in high-density confinements such as those now being engineered for high-yield aquaculture. Attributes considered are discussed in the context of the various aquacultural ecosystems in which the specific biotype is expected to achieve satisfactory growth and survival. Correlative with bionomic criteria, economic requirements are posed and evaluated in an effort to define a socially and financially profitable agribusiness system. Investment requirements and operating costs are considered in terms of expected returns. However, since production alone is insufficient to sustain an enterprise - i.e., the product must be sold - production costs must be judged against market values. Therefore, ultimate use or consumer acceptance criteria are incorporated into the list of essential requirements for a candidate species for aquafarming.

Children’s Hospital of Pittsburgh and Diabetes Institute of the Walter Reed Health Care System Genetic Screening in Diabetes: Candidate Gene Analysis for Diabetic Retinopathy

Science.gov (United States)

2010-05-01

Screening in Diabetes : Candidate Gene Analysis for Diabetic Retinopathy PRINCIPAL INVESTIGATOR: Robert A. Vigersky, COL MC CONTRACTING ORGANIZATION... Diabetes Institute of the Walter Reed Health Care System Genetic Screening in Diabetes : Candidate Gene Analysis for Diabetic Retinopathy 5c. PROGRAM... diabetic  neuropathy, and  diabetic   retinopathy .  This was an observational study in which the investigators obtained DNA samples from the blood of

Dark matter candidates

International Nuclear Information System (INIS)

Turner, M.S.

1989-01-01

One of the simplest, yet most profound, questions we can ask about the Universe is, how much stuff is in it, and further what is that stuff composed of? Needless to say, the answer to this question has very important implications for the evolution of the Universe, determining both the ultimate fate and the course of structure formation. Remarkably, at this late date in the history of the Universe we still do not have a definitive answer to this simplest of questions---although we have some very intriguing clues. It is known with certainty that most of the material in the Universe is dark, and we have the strong suspicion that the dominant component of material in the Cosmos is not baryons, but rather is exotic relic elementary particles left over from the earliest, very hot epoch of the Universe. If true, the Dark Matter question is a most fundamental one facing both particle physics and cosmology. The leading particle dark matter candidates are: the axion, the neutralino, and a light neutrino species. All three candidates are accessible to experimental tests, and experiments are now in progress. In addition, there are several dark horse, long shot, candidates, including the superheavy magnetic monopole and soliton stars. 13 refs

Blend Analysis of HATNet Transit Candidates

Directory of Open Access Journals (Sweden)

Bakos G.Á.

2011-02-01

Full Text Available Candidate transiting planet systems discovered by wide-field groundbased surveys must go through an intensive follow-up procedure to distinguish the true transiting planets from the much more common false positives. Especially pernicious are configurations of three or more stars which produce radial velocity and light curves that are similar to those of single stars transited by a planet. In this contribution we describe the methods used by the HATNet team to reject these blends, giving a few illustrative examples.

Academic Dishonesty Tendencies and Values of Teacher Candidates

Directory of Open Access Journals (Sweden)

Ayşegül KADI

2016-12-01

Full Text Available The purpose of this study was to examine the values and academic dishonesty tendencies of teacher candidates. The population of this study included teacher candidates who received pedagogic formation education during 2013-2014 academic semester at the Faculty of Education at Ege University. The study was conducted with 244 teacher candidates, who were chosen through convenient sampling method. Academic Dishonesty Tendency Scale and Portrait Values Questionnaire were used to collect data. It was a correlational study due to the investigation of the relationship between values and academic dishonesty tendencies of teacher candidates. It was also a survey study since the academic dishonesty tendencies and values of teacher candidates were examined in relation to demographic variables. The results suggested that there wass a significant difference between the values and academic dishonesty tendencies of teacher candidates for gender variable. The values and academic dishonesty tendencies of teacher candidates did not differ for different fields of study. There was not a significant relationship between the academic dishonesty tendencies and values of teacher candidates.

An evaluation of reactor cooling and coupled hydrogen production processes using the modular helium reactor

International Nuclear Information System (INIS)

Harvego, E.A.; Reza, S.M.M.; Richards, M.; Shenoy, A.

2006-01-01

The high-temperature characteristics of the modular helium reactor (MHR) make it a strong candidate for producing hydrogen using either thermochemical or high-temperature electrolysis (HTE) processes. Using heat from the MHR to drive a sulfur-iodine (SI) thermochemical hydrogen production process has been the subject of a U.S. Department of Energy sponsored Nuclear Engineering Research Initiative (NERI) project led by General Atomics, with participation from the Idaho National Laboratory (INL) and Texas A and M University. While the focus of much of the initial work was on the SI thermochemical production of hydrogen, recent activities included development of a preconceptual design for an integral HTE hydrogen production plant driven by the process heat and electricity produced by a 600 MW MHR. This paper describes ATHENA analyses performed to evaluate alternative primary system cooling configurations for the MHR to minimize peak reactor vessel and core temperatures while achieving core helium outlet temperatures in the range of 900-1000 deg. C that are needed for the efficient production of hydrogen using either the SI or HTE process. The cooling schemes investigated are intended to ensure peak fuel temperatures do not exceed specified limits under normal or transient upset conditions, and that reactor vessel temperatures do not exceed American Society of Mechanical Engineers (ASME) code limits for steady-state or transient conditions using standard light water reactor vessel materials. Preconceptual designs for SI and HTE hydrogen production plants driven by one or more 600 MW MHRs at helium outlet temperatures in the range of 900-1000 deg. C are described and compared. An initial SAPHIRE model to evaluate the reliability, maintainability, and availability of the SI hydrogen production plant is also described. Finally, a preliminary flowsheet for a conceptual design of an HTE hydrogen production plant coupled to a 600 MW modular helium reactor is presented and

FASTER test reactor preconceptual design report summary

Energy Technology Data Exchange (ETDEWEB)

Grandy, C. [Argonne National Lab. (ANL), Argonne, IL (United States); Belch, H. [Argonne National Lab. (ANL), Argonne, IL (United States); Brunett, A. [Argonne National Lab. (ANL), Argonne, IL (United States); Heidet, F. [Argonne National Lab. (ANL), Argonne, IL (United States); Hill, R. [Argonne National Lab. (ANL), Argonne, IL (United States); Hoffman, E. [Argonne National Lab. (ANL), Argonne, IL (United States); Jin, E. [Argonne National Lab. (ANL), Argonne, IL (United States); Mohamed, W. [Argonne National Lab. (ANL), Argonne, IL (United States); Moisseytsev, A. [Argonne National Lab. (ANL), Argonne, IL (United States); Passerini, S. [Argonne National Lab. (ANL), Argonne, IL (United States); Sienicki, J. [Argonne National Lab. (ANL), Argonne, IL (United States); Sumner, T. [Argonne National Lab. (ANL), Argonne, IL (United States); Vilim, R. [Argonne National Lab. (ANL), Argonne, IL (United States); Hayes, Steven [Argonne National Lab. (ANL), Argonne, IL (United States)

2016-02-29

The FASTER reactor plant is a sodium-cooled fast spectrum test reactor that provides high levels of fast and thermal neutron flux for scientific research and development. The 120MWe FASTER reactor plant has a superheated steam power conversion system which provides electrical power to a local grid allowing for recovery of operating costs for the reactor plant.

Evaluating candidate reactions to selection practices using organisational justice theory.

Science.gov (United States)

Patterson, Fiona; Zibarras, Lara; Carr, Victoria; Irish, Bill; Gregory, Simon

2011-03-01

This study aimed to examine candidate reactions to selection practices in postgraduate medical training using organisational justice theory. We carried out three independent cross-sectional studies using samples from three consecutive annual recruitment rounds. Data were gathered from candidates applying for entry into UK general practice (GP) training during 2007, 2008 and 2009. Participants completed an evaluation questionnaire immediately after the short-listing stage and after the selection centre (interview) stage. Participants were doctors applying for GP training in the UK. Main outcome measures were participants' evaluations of the selection methods and perceptions of the overall fairness of each selection stage (short-listing and selection centre). A total of 23,855 evaluation questionnaires were completed (6893 in 2007, 10,497 in 2008 and 6465 in 2009). Absolute levels of perceptions of fairness of all the selection methods at both the short-listing and selection centre stages were consistently high over the 3years. Similarly, all selection methods were considered to be job-related by candidates. However, in general, candidates considered the selection centre stage to be significantly fairer than the short-listing stage. Of all the selection methods, the simulated patient consultation completed at the selection centre stage was rated as the most job-relevant. This is the first study to use a model of organisational justice theory to evaluate candidate reactions during selection into postgraduate specialty training. The high-fidelity selection methods are consistently viewed as more job-relevant and fairer by candidates. This has important implications for the design of recruitment systems for all specialties and, potentially, for medical school admissions. Using this approach, recruiters can systematically compare perceptions of the fairness and job relevance of various selection methods. © Blackwell Publishing Ltd 2011.

JELLYFISH GALAXY CANDIDATES AT LOW REDSHIFT

Energy Technology Data Exchange (ETDEWEB)

Poggianti, B. M.; Fasano, G.; Omizzolo, A.; Gullieuszik, M.; Bettoni, D.; Paccagnella, A. [INAF-Astronomical Observatory of Padova (Italy); Moretti, A.; D’Onofrio, M. [Physics and Astronomy Department, University of Padova (Italy); Jaffé, Y. L. [Department of Astronomy, Universidad de Concepción, Concepción (Chile); Vulcani, B. [Kavli Institute for the Physics and Mathematics of the universe (WPI), The University of Tokyo Institutes for Advanced Study (UTIAS), the University of Tokyo, Kashiwa, 277-8582 (Japan); Fritz, J. [Centro de Radioastronomía y Astrofísica, CRyA, UNAM, Michoacán (Mexico); Couch, W. [Australian Astronomical Observatory, North Ryde, NSW 1670 (Australia)

2016-03-15

Galaxies that are being stripped of their gas can sometimes be recognized from their optical appearance. Extreme examples of stripped galaxies are the so-called “jellyfish galaxies” that exhibit tentacles of debris material with a characteristic jellyfish morphology. We have conducted the first systematic search for galaxies that are being stripped of their gas at low-z (z = 0.04−0.07) in different environments, selecting galaxies with varying degrees of morphological evidence for stripping. We have visually inspected B- and V-band images and identified 344 candidates in 71 galaxy clusters of the OMEGAWINGS+WINGS sample and 75 candidates in groups and lower mass structures in the PM2GC sample. We present the atlas of stripping candidates and a first analysis of their environment and their basic properties, such as morphologies, star formation rates and galaxy stellar masses. Candidates are found in all clusters and at all clustercentric radii, and their number does not correlate with the cluster velocity dispersion σ or X-ray luminosity L{sub X}. Interestingly, convincing cases of candidates are also found in groups and lower mass halos (10{sup 11}−10{sup 14}M{sub ⊙}), although the physical mechanism at work needs to be securely identified. All the candidates are disky, have stellar masses ranging from log M/M{sub ⊙} < 9 to > 11.5 and the majority of them form stars at a rate that is on average a factor of 2 higher (2.5σ) compared to non-stripped galaxies of similar mass. The few post-starburst and passive candidates have weak stripping evidence. We conclude that disturbed morphologies suggestive of stripping phenomena are ubiquitous in clusters and could be present even in groups and low mass halos. Further studies will reveal the physics of the gas stripping and clarify the mechanisms at work.

Scalar tetraquark candidates on the lattice

International Nuclear Information System (INIS)

Berlin, Joshua

2017-01-01

The topic of this thesis is the investigation of scalar tetraquark candidates from lattice QCD. It is motivated by a previous study originating in the twisted mass collaboration. The initial tetraquark candidate of choice is the a 0 (980), an isovector in the nonet of light scalars (J P =0 + ). This channel is still poorly understood. It displays an inverted mass hierarchy to what is expected from the conventional quark model and the a 0 (980) and f 0 (980) feature a surprising mass degeneracy. For this reasons the a 0 (980) is a long assumed tetraquark candidate in the literature. We follow a methodological approach by studying the sensitivity of the scalar spectrum with fully dynamical quarks to a large basis of two-quark and four-quark creation operators. Ultimately, the candidate has to be identified in the direct vicinity of two two-particles states, which is understandably inevitable for a tetraquark candidate. To succeed in this difficult task two-meson creation operators are essential to employ in this channel. By localized four-quark operators we intend to probe the Hamiltonian on eigenstates with a closely bound four-quark structure.

Scalar tetraquark candidates on the lattice

Energy Technology Data Exchange (ETDEWEB)

Berlin, Joshua

2017-07-01

The topic of this thesis is the investigation of scalar tetraquark candidates from lattice QCD. It is motivated by a previous study originating in the twisted mass collaboration. The initial tetraquark candidate of choice is the a{sub 0}(980), an isovector in the nonet of light scalars (J{sup P}=0{sup +}). This channel is still poorly understood. It displays an inverted mass hierarchy to what is expected from the conventional quark model and the a{sub 0}(980) and f{sub 0}(980) feature a surprising mass degeneracy. For this reasons the a{sub 0}(980) is a long assumed tetraquark candidate in the literature. We follow a methodological approach by studying the sensitivity of the scalar spectrum with fully dynamical quarks to a large basis of two-quark and four-quark creation operators. Ultimately, the candidate has to be identified in the direct vicinity of two two-particles states, which is understandably inevitable for a tetraquark candidate. To succeed in this difficult task two-meson creation operators are essential to employ in this channel. By localized four-quark operators we intend to probe the Hamiltonian on eigenstates with a closely bound four-quark structure.

A New Way to Confirm Planet Candidates

Science.gov (United States)

Kohler, Susanna

2016-05-01

What was the big deal behind the Kepler news conference yesterday? Its not just that the number of confirmed planets found by Kepler has more than doubled (though thats certainly exciting news!). Whats especially interesting is the way in which these new planets were confirmed.Number of planet discoveries by year since 1995, including previous non-Kepler discoveries (blue), previous Kepler discoveries (light blue) and the newly validated Kepler planets (orange). [NASA Ames/W. Stenzel; Princeton University/T. Morton]No Need for Follow-UpBefore Kepler, the way we confirmed planet candidates was with follow-up observations. The candidate could be validated either by directly imaging (which is rare) or obtaining a large number radial-velocity measurements of the wobble of the planets host star due to the planets orbit. But once Kepler started producing planet candidates, these approaches to validation became less feasible. A lot of Kepler candidates are small and orbit faint stars, making follow-up observations difficult or impossible.This problem is what inspired the development of whats known as probabilistic validation, an analysis technique that involves assessing the likelihood that the candidates signal is caused by various false-positive scenarios. Using this technique allows astronomers to estimate the likelihood of a candidate signal being a true planet detection; if that likelihood is high enough, the planet candidate can be confirmed without the need for follow-up observations.A breakdown of the catalog of Kepler Objects of Interest. Just over half had previously been identified as false positives or confirmed as candidates. 1284 are newly validated, and another 455 have FPP of1090%. [Morton et al. 2016]Probabilistic validation has been used in the past to confirm individual planet candidates in Kepler data, but now Timothy Morton (Princeton University) and collaborators have taken this to a new level: they developed the first code thats designed to do fully

Candidate thermal energy storage technologies for solar industrial process heat applications

Science.gov (United States)

Furman, E. R.

1979-01-01

A number of candidate thermal energy storage system elements were identified as having the potential for the successful application of solar industrial process heat. These elements which include storage media, containment and heat exchange are shown.

76 FR 36130 - Call for Candidates

Science.gov (United States)

2011-06-21

... financial information in decision-making. The Board meets in Washington, DC, for two days every other month... FEDERAL ACCOUNTING STANDARDS ADVISORY BOARD Call for Candidates AGENCY: Federal Accounting... candidates. Any applicant who provided the Federal Accounting Standards Advisory Board (FASAB or the Board...

Electoral Competition when Candidates are Better Informed than Voters

DEFF Research Database (Denmark)

Jensen, Thomas

candidates are both completely office-motivated but differ in state-dependent quality. Voters have some information about the state but candidates are better informed. If voters' information is unknown to the candidates when they take positions and sufficiently accurate then candidates will, in refined...

Follow-up Observations of SDSS and CRTS Candidate Cataclysmic Variables II

Science.gov (United States)

Szkody, Paula; Everett, Mark E.; Dai, Zhibin; Serna-Grey, Donald

2018-01-01

Spectra of 38 candidate or known cataclysmic variables are presented. Most are candidate dwarf novae or systems containing possible highly magnetic white dwarfs, while a few (KR Aur, LS Peg, V380 Oph, and V694 Mon) are previously known objects caught in unusual states. Individual spectra are used to confirm a dwarf nova nature or other classification while radial velocities of 15 systems provide orbital periods and velocity amplitudes that aid in determining the nature of the objects. Our results substantiate a polar nature for four objects, find an eclipsing SW Sex star below the period gap, another as a likely intermediate polar, as well as two dwarf novae with periods in the middle of the gap. Based on observations obtained with the Apache Point Observatory (APO) 3.5 m telescope, which is owned and operated by the Astrophysical Research Consortium (ARC).

Play to Learn, Play to Create, Play to Innovate

DEFF Research Database (Denmark)

Nielsen, Louise Møller; Hansen, Poul H. Kyvsgård; Mabogunje, Ade

2007-01-01

When designing or developing products it is a well known principle to use different types of models and prototypes as a driver for the decision making process. But in the pre-conceptual process these types of drivers are often not at hand. Instead the pre-conceptual process is influenced by a large...... it would have on the process. At this stage in the research there are several interesting implications....

11 CFR 110.13 - Candidate debates.

Science.gov (United States)

2010-01-01

... debates include at least two candidates; and (2) The staging organization(s) does not structure the... PROHIBITIONS § 110.13 Candidate debates. (a) Staging organizations. (1) Nonprofit organizations described in 26..., subparts D and E. (b) Debate structure. The structure of debates staged in accordance with this section and...

Normal evolution of a spent fuel repository at the candidate sites in Finland

International Nuclear Information System (INIS)

Grawford, M.B.; Wilmot, R.D.

1998-12-01

The Finnish disposal concept for spent nuclear fuel envisages burial of the fuel in a repository excavated at a depth of around 500 m in crystalline bedrock. Since 1983, a programme has been underway in Finland to select a potential site for such a repository. The programme is now in the final stages of selecting one site for further detailed characterisation from a list of four candidate sites at Kivetty, Romuvaara, Olkiluoto, and Haestholmen. Each stage of the site selection process has been supported by a major performance assessment (PA) exercise. The aim of this report is to describe the normal evolution of a repository system at the four candidate Finnish sites as input to development of the next PA, known as TILA-99. The report summarises the disposal concept and the present-day characteristics of each candidate site, and considers the most likely future changes in both the natural environment and the engineered components of the disposal system. The description concentrates on the key features, events and processes (FEPs) controlling behaviour and evolution of the disposal system. It is assumed that all the canisters are intact following emplacement and repository closure. FEPs that occur but which do not significantly affect system behaviour and evolution are only briefly described. FEPs with a low probability of occurrence are mentioned as appropriate. The report provides a map to the key Finnish reports and other work that underlies and supports the description of normal evolution. Differences between the four candidate sites in terms of their expected normal evolution are summarised. None of the differences are sufficient to prevent each site from behaving as a 'normal' site, the evolution of which is summarised over time in the final section of the report. (author)

Normal evolution of a spent fuel repository at the candidate sites in Finland

Energy Technology Data Exchange (ETDEWEB)

Grawford, M.B.; Wilmot, R.D. [Galson Sciences Limited, Rutland (United Kingdom)

1998-12-01

The Finnish disposal concept for spent nuclear fuel envisages burial of the fuel in a repository excavated at a depth of around 500 m in crystalline bedrock. Since 1983, a programme has been underway in Finland to select a potential site for such a repository. The programme is now in the final stages of selecting one site for further detailed characterisation from a list of four candidate sites at Kivetty, Romuvaara, Olkiluoto, and Haestholmen. Each stage of the site selection process has been supported by a major performance assessment (PA) exercise. The aim of this report is to describe the normal evolution of a repository system at the four candidate Finnish sites as input to development of the next PA, known as TILA-99. The report summarises the disposal concept and the present-day characteristics of each candidate site, and considers the most likely future changes in both the natural environment and the engineered components of the disposal system. The description concentrates on the key features, events and processes (FEPs) controlling behaviour and evolution of the disposal system. It is assumed that all the canisters are intact following emplacement and repository closure. FEPs that occur but which do not significantly affect system behaviour and evolution are only briefly described. FEPs with a low probability of occurrence are mentioned as appropriate. The report provides a map to the key Finnish reports and other work that underlies and supports the description of normal evolution. Differences between the four candidate sites in terms of their expected normal evolution are summarised. None of the differences are sufficient to prevent each site from behaving as a `normal` site, the evolution of which is summarised over time in the final section of the report. (author) 155 refs.

Candidate marketing takes the guessing game out of choosing employers.

Science.gov (United States)

Russell, Judith; Havel, Stacey

2010-01-01

Candidate marketing builds a foundation for relationships between employers and potential employees. Additionally, candidate marketing differentiates organizations in the marketplace. Organizations using candidate marketing to communicate the employer brand can expect a higher quality of candidates, and new employees are better prepared for the work environment and culture. Today, organizations can use a variety of integrated tools and techniques to communicate and build relationships with candidates. Candidate marketing demonstrates an organization's willingness towards transparency, and ability to invite open conversations between candidates and members of the organizations.

Relationship between candidate communication ability and oral certification examination scores.

Science.gov (United States)

Lunz, Mary E; Bashook, Philip G

2008-12-01

Structured case-based oral examinations are widely used in medical certifying examinations in the USA. These orals assess the candidate's decision-making skills using real or realistic patient cases. Frequently mentioned but not empirically evaluated is the potential bias introduced by the candidate's communication ability. This study aimed to assess the relationship between candidate communication ability and medical certification oral examination scores. Non-doctor communication observers rated a random sample of 90 candidates on communication ability during a medical oral certification examination. The multi-facet Rasch model was used to analyse the communication survey and the oral examination data. The multi-facet model accounts for observer and examiner severity bias. anova was used to measure differences in communication ability between passing and failing candidates and candidates grouped by level of communication ability. Pearson's correlations were used to compare candidate communication ability and oral certification examination performance. Candidate separation reliability values for the communication survey and the oral examination were 0.85 and 0.97, respectively, suggesting accurate candidate measurement. The correlation between communication scores and oral examination scores was 0.10. No significant difference was found between passing and failing candidates for measured communication ability. When candidates were grouped by high, moderate and low communication ability, there was no significant difference in their oral certification examination performance. Candidates' communication ability has little relationship to candidate performance on high-stakes, case-based oral examinations. Examiners for this certifying examination focused on assessing candidate decision-making ability and were not influenced by candidate communication ability.

TRANSIT TIMING OBSERVATIONS FROM KEPLER. V. TRANSIT TIMING VARIATION CANDIDATES IN THE FIRST SIXTEEN MONTHS FROM POLYNOMIAL MODELS

Energy Technology Data Exchange (ETDEWEB)

Ford, Eric B. [Astronomy Department, University of Florida, 211 Bryant Space Sciences Center, Gainesville, FL 32111 (United States); Ragozzine, Darin; Holman, Matthew J. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Rowe, Jason F.; Barclay, Thomas; Borucki, William J.; Bryson, Stephen T.; Caldwell, Douglas A.; Kinemuchi, Karen; Koch, David G.; Lissauer, Jack J.; Still, Martin; Tenenbaum, Peter [NASA Ames Research Center, Moffett Field, CA 94035 (United States); Steffen, Jason H. [Fermilab Center for Particle Astrophysics, P.O. Box 500, MS 127, Batavia, IL 60510 (United States); Batalha, Natalie M. [Department of Physics and Astronomy, San Jose State University, San Jose, CA 95192 (United States); Fabrycky, Daniel C. [UCO/Lick Observatory, University of California, Santa Cruz, CA 95064 (United States); Gautier, Thomas N. [Jet Propulsion Laboratory/California Institute of Technology, Pasadena, CA 91109 (United States); Ibrahim, Khadeejah A.; Uddin, Kamal [Orbital Sciences Corporation/NASA Ames Research Center, Moffett Field, CA 94035 (United States); Kjeldsen, Hans, E-mail: eford@astro.ufl.edu [Department of Physics and Astronomy, Aarhus University, DK-8000 Aarhus C (Denmark); and others

2012-09-10

Transit timing variations provide a powerful tool for confirming and characterizing transiting planets, as well as detecting non-transiting planets. We report the results of an updated transit timing variation (TTV) analysis for 1481 planet candidates based on transit times measured during the first sixteen months of Kepler observations. We present 39 strong TTV candidates based on long-term trends (2.8% of suitable data sets). We present another 136 weaker TTV candidates (9.8% of suitable data sets) based on the excess scatter of TTV measurements about a linear ephemeris. We anticipate that several of these planet candidates could be confirmed and perhaps characterized with more detailed TTV analyses using publicly available Kepler observations. For many others, Kepler has observed a long-term TTV trend, but an extended Kepler mission will be required to characterize the system via TTVs. We find that the occurrence rate of planet candidates that show TTVs is significantly increased ({approx}68%) for planet candidates transiting stars with multiple transiting planet candidates when compared to planet candidates transiting stars with a single transiting planet candidate.

Candidate genes for COPD: current evidence and research

Directory of Open Access Journals (Sweden)

Kim WJ

2015-10-01

Full Text Available Woo Jin Kim,1 Sang Do Lee2 1Department of Internal Medicine and Environmental Health Center, Kangwon National University, Chuncheon, 2Department of Pulmonary and Critical Care Medicine, Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea Abstract: COPD is a common complex disease characterized by progressive airflow limitation. Several genome-wide association studies (GWASs have discovered genes that are associated with COPD. Recently, candidate genes for COPD identified by GWASs include CHRNA3/5 (cholinergic nicotine receptor alpha 3/5, IREB2 (iron regulatory binding protein 2, HHIP (hedgehog-interacting protein, FAM13A (family with sequence similarity 13, member A, and AGER (advanced glycosylation end product–specific receptor. Their association with COPD susceptibility has been replicated in multiple populations. Since these candidate genes have not been considered in COPD, their pathological roles are still largely unknown. Herein, we review some evidences that they can be effective drug targets or serve as biomarkers for diagnosis or subtyping. However, more study is required to understand the functional roles of these candidate genes. Future research is needed to characterize the effect of genetic variants, validate gene function in humans and model systems, and elucidate the genes’ transcriptional and posttranscriptional regulatory mechanisms. Keywords: chronic obstructive pulmonary disease, genetics, genome-wide association study

Improving mass candidate detection in mammograms via feature maxima propagation and local feature selection.

Science.gov (United States)

Melendez, Jaime; Sánchez, Clara I; van Ginneken, Bram; Karssemeijer, Nico

2014-08-01

Mass candidate detection is a crucial component of multistep computer-aided detection (CAD) systems. It is usually performed by combining several local features by means of a classifier. When these features are processed on a per-image-location basis (e.g., for each pixel), mismatching problems may arise while constructing feature vectors for classification, which is especially true when the behavior expected from the evaluated features is a peaked response due to the presence of a mass. In this study, two of these problems, consisting of maxima misalignment and differences of maxima spread, are identified and two solutions are proposed. The first proposed method, feature maxima propagation, reproduces feature maxima through their neighboring locations. The second method, local feature selection, combines different subsets of features for different feature vectors associated with image locations. Both methods are applied independently and together. The proposed methods are included in a mammogram-based CAD system intended for mass detection in screening. Experiments are carried out with a database of 382 digital cases. Sensitivity is assessed at two sets of operating points. The first one is the interval of 3.5-15 false positives per image (FPs/image), which is typical for mass candidate detection. The second one is 1 FP/image, which allows to estimate the quality of the mass candidate detector's output for use in subsequent steps of the CAD system. The best results are obtained when the proposed methods are applied together. In that case, the mean sensitivity in the interval of 3.5-15 FPs/image significantly increases from 0.926 to 0.958 (p < 0.0002). At the lower rate of 1 FP/image, the mean sensitivity improves from 0.628 to 0.734 (p < 0.0002). Given the improved detection performance, the authors believe that the strategies proposed in this paper can render mass candidate detection approaches based on image location classification more robust to feature

The gravitational lens candidate HE 1104-1805 and the size of absorption systems

NARCIS (Netherlands)

Smette, A; Robertson, JG; Shaver, PA; Reimers, D; Wisotzki, L; Kohler, T; Kochanek, CS; Hewitt, JN

1996-01-01

We obtained 1.2 Angstrom resolution spectra over the range 3175 - 7575 Angstrom for the two components of the gravitational lens candidate HE 1104-1805 (z = 2.31, m(B) = 16.7 and 18.6, separation = 3.0 arcsec; cf. Wisotzki et al. 1993), with the aim of setting limits on the sizes of the clouds

Three candidate double clusters in the LMC: truth or dare?

Science.gov (United States)

Dalessandro, Emanuele; Zocchi, Alice; Varri, Anna Lisa; Mucciarelli, Alessio; Bellazzini, Michele; Ferraro, Francesco R.; Lanzoni, Barbara; Lapenna, Emilio; Origlia, Livia

2018-02-01

The Large Magellanic Cloud (LMC) hosts a large number of candidate stellar cluster pairs. Binary stellar clusters provide important clues about cluster formation processes and the evolutionary history of the host galaxy. However, to properly extract and interpret this information, it is crucial to fully constrain the fraction of real binary systems and their physical properties. Here we present a detailed photometric analysis based on ESO-FORS2 images of three candidate cluster multiplets in the LMC, namely SL349-SL353, SL385-SL387-NGC 1922 and NGC 1836-BRHT4b-NGC 1839. For each cluster, we derived ages, structural parameters and morphological properties. We have also estimated the degree of filling of their Roche lobe, as an approximate tool to measure the strength of the tidal perturbations induced by the LMC. We find that the members of the possible pairs SL349-SL353 and BRHT4b-NGC 1839 have a similar age (t = 1.00 ± 0.12 Gyr and t = 140 ± 15 Myr, respectively), thus possibly hinting at a common origin of their member systems. We also find that all candidate pairs in our sample show evidence of intracluster overdensities that can be a possible indication of real binarity. Particularly interesting is the case of SL349-SL353. In fact, SL353 is relatively close to the condition of critical filling, thus suggesting that these systems might actually constitute an energetically bound pair. It is therefore key to pursue a detailed kinematic screening of such clusters, without which, at present, we do not dare making a conclusive statement about the true nature of this putative pair.

Dissecting the organ specificity of insecticide resistance candidate genes in Anopheles gambiae: known and novel candidate genes.

Science.gov (United States)

Ingham, Victoria A; Jones, Christopher M; Pignatelli, Patricia; Balabanidou, Vasileia; Vontas, John; Wagstaff, Simon C; Moore, Jonathan D; Ranson, Hilary

2014-11-25

The elevated expression of enzymes with insecticide metabolism activity can lead to high levels of insecticide resistance in the malaria vector, Anopheles gambiae. In this study, adult female mosquitoes from an insecticide susceptible and resistant strain were dissected into four different body parts. RNA from each of these samples was used in microarray analysis to determine the enrichment patterns of the key detoxification gene families within the mosquito and to identify additional candidate insecticide resistance genes that may have been overlooked in previous experiments on whole organisms. A general enrichment in the transcription of genes from the four major detoxification gene families (carboxylesterases, glutathione transferases, UDP glucornyltransferases and cytochrome P450s) was observed in the midgut and malpighian tubules. Yet the subset of P450 genes that have previously been implicated in insecticide resistance in An gambiae, show a surprisingly varied profile of tissue enrichment, confirmed by qPCR and, for three candidates, by immunostaining. A stringent selection process was used to define a list of 105 genes that are significantly (p ≤0.001) over expressed in body parts from the resistant versus susceptible strain. Over half of these, including all the cytochrome P450s on this list, were identified in previous whole organism comparisons between the strains, but several new candidates were detected, notably from comparisons of the transcriptomes from dissected abdomen integuments. The use of RNA extracted from the whole organism to identify candidate insecticide resistance genes has a risk of missing candidates if key genes responsible for the phenotype have restricted expression within the body and/or are over expression only in certain tissues. However, as transcription of genes implicated in metabolic resistance to insecticides is not enriched in any one single organ, comparison of the transcriptome of individual dissected body parts cannot

Recent Total Ionizing Dose and Displacement Damage Compendium of Candidate Electronics for NASA Space Systems

Science.gov (United States)

Cochran, Donna J.; Boutte, Alvin J.; Campola, Michael J.; Carts, Martin A.; Casey, Megan C.; Chen, Dakai; LaBel, Kenneth A.; Ladbury, Raymond L.; Lauenstein, Jean-Marie; Marshall, Cheryl J.;

COOL YOUNG STARS IN THE NORTHERN HEMISPHERE: β PICTORIS AND AB DORADUS MOVING GROUP CANDIDATES

International Nuclear Information System (INIS)

Schlieder, Joshua E.; Simon, Michal; Lépine, Sébastien

2012-01-01

As part of our continuing effort to identify new, low-mass members of nearby, young moving groups (NYMGs), we present a list of young, low-mass candidates in the northern hemisphere. We used our proven proper-motion selection procedure and ROSAT X-ray and GALEX-UV activity indicators to identify 204 young stars as candidate members of the β Pictoris and AB Doradus NYMGs. Definitive membership assignment of a given candidate will require a measurement of its radial velocity and distance. We present a simple system of indices to characterize the young candidates and help prioritize follow-up observations. New group members identified in this candidate list will be high priority targets for (1) exoplanet direct imaging searches, (2) the study of post-T-Tauri astrophysics, (3) understanding recent local star formation, and (4) the study of local galactic kinematics. Information available now allows us to identify eight likely new members in the list. Two of these, a late-K and an early-M dwarf, we find to be likely members of the β Pic group. The other six stars are likely members of the AB Dor moving group. These include an M dwarf triple system, and three very cool objects that may be young brown dwarfs, making them the lowest-mass, isolated objects proposed in the AB Dor moving group to date.

Evaluating historical candidate genes for schizophrenia

DEFF Research Database (Denmark)

Farrell, M S; Werge, T; Sklar, P

2015-01-01

Prior to the genome-wide association era, candidate gene studies were a major approach in schizophrenia genetics. In this invited review, we consider the current status of 25 historical candidate genes for schizophrenia (for example, COMT, DISC1, DTNBP1 and NRG1). The initial study for 24 of thes...

Spatially Resolved Imaging and Spectroscopy of Candidate Dual Active Galactic Nuclei

Science.gov (United States)

McGurk, R. C.; Max, C. E.; Medling, A. M.; Shields, G. A.; Comerford, J. M.

2015-09-01

When galaxies merge, both central supermassive black holes are immersed in a dense and chaotic environment. If there is sufficient gas in the nuclear regions, one expects to see close pairs of active galactic nuclei (AGNs), or dual AGNs, in a fraction of galaxy mergers. However, finding them remains a challenge. The presence of double-peaked [O iii] emission lines has been proposed as a technique to select dual AGNs efficiently. We studied a sample of double-peaked narrow [O iii] emitting AGNs from Sloan Digital Sky Survey (SDSS) DR7. By obtaining new and archival high spatial resolution images taken with the Keck II Laser Guide Star Adaptive Optics system and the near-infrared camera NIRC2, we show that 30% of 140 double-peaked [O iii] emission line SDSS AGNs have two spatial components within a 3″ radius. However, spatially resolved spectroscopy or X-ray observations are needed to confirm these galaxy pairs as systems containing two AGNs. We followed up three spatially double candidate dual AGNs with integral field spectroscopy from Keck OSIRIS and 10 candidates with long-slit spectroscopy from the Shane Kast Double Spectrograph at Lick Observatory. We find that the double-peaked emission lines in our sample of 12 candidates are caused by: one dual AGN (SDSS J114642.47+511029.6), one confirmed outflow and four likely outflows, two pairs of star-forming galaxies, one candidate indeterminate due to sky line interference, and three AGNs with spatially coincident double [O iii] peaks, likely due to unresolved complex narrow line kinematics, outflows, binary AGN, or small-scale jets.

SPATIALLY RESOLVED IMAGING AND SPECTROSCOPY OF CANDIDATE DUAL ACTIVE GALACTIC NUCLEI

Energy Technology Data Exchange (ETDEWEB)

McGurk, R. C.; Max, C. E. [Astronomy Department and UCO-Lick Observatory, University of California, Santa Cruz, CA 95064 (United States); Medling, A. M. [Research School of Astronomy and Astrophysics, Australian National University, Mount Stromlo Observatory, Cotter Road, Weston Creek, ACT 2611 (Australia); Shields, G. A. [Laguna Falls Institute for Astrophysics, Austin, TX 78746 (United States); Comerford, J. M., E-mail: rosalie.mcgurk@gmail.com, E-mail: max@ucolick.org, E-mail: anne.medling@anu.edu.au, E-mail: shields@lfastro.org, E-mail: julie.comerford@colorado.edu [Department of Astrophysical and Planetary Sciences, University of Colorado, Boulder, CO 80309 (United States)

2015-09-20

When galaxies merge, both central supermassive black holes are immersed in a dense and chaotic environment. If there is sufficient gas in the nuclear regions, one expects to see close pairs of active galactic nuclei (AGNs), or dual AGNs, in a fraction of galaxy mergers. However, finding them remains a challenge. The presence of double-peaked [O iii] emission lines has been proposed as a technique to select dual AGNs efficiently. We studied a sample of double-peaked narrow [O iii] emitting AGNs from Sloan Digital Sky Survey (SDSS) DR7. By obtaining new and archival high spatial resolution images taken with the Keck II Laser Guide Star Adaptive Optics system and the near-infrared camera NIRC2, we show that 30% of 140 double-peaked [O iii] emission line SDSS AGNs have two spatial components within a 3″ radius. However, spatially resolved spectroscopy or X-ray observations are needed to confirm these galaxy pairs as systems containing two AGNs. We followed up three spatially double candidate dual AGNs with integral field spectroscopy from Keck OSIRIS and 10 candidates with long-slit spectroscopy from the Shane Kast Double Spectrograph at Lick Observatory. We find that the double-peaked emission lines in our sample of 12 candidates are caused by: one dual AGN (SDSS J114642.47+511029.6), one confirmed outflow and four likely outflows, two pairs of star-forming galaxies, one candidate indeterminate due to sky line interference, and three AGNs with spatially coincident double [O iii] peaks, likely due to unresolved complex narrow line kinematics, outflows, binary AGN, or small-scale jets.

SPATIALLY RESOLVED IMAGING AND SPECTROSCOPY OF CANDIDATE DUAL ACTIVE GALACTIC NUCLEI

International Nuclear Information System (INIS)

McGurk, R. C.; Max, C. E.; Medling, A. M.; Shields, G. A.; Comerford, J. M.

2015-01-01

When galaxies merge, both central supermassive black holes are immersed in a dense and chaotic environment. If there is sufficient gas in the nuclear regions, one expects to see close pairs of active galactic nuclei (AGNs), or dual AGNs, in a fraction of galaxy mergers. However, finding them remains a challenge. The presence of double-peaked [O iii] emission lines has been proposed as a technique to select dual AGNs efficiently. We studied a sample of double-peaked narrow [O iii] emitting AGNs from Sloan Digital Sky Survey (SDSS) DR7. By obtaining new and archival high spatial resolution images taken with the Keck II Laser Guide Star Adaptive Optics system and the near-infrared camera NIRC2, we show that 30% of 140 double-peaked [O iii] emission line SDSS AGNs have two spatial components within a 3″ radius. However, spatially resolved spectroscopy or X-ray observations are needed to confirm these galaxy pairs as systems containing two AGNs. We followed up three spatially double candidate dual AGNs with integral field spectroscopy from Keck OSIRIS and 10 candidates with long-slit spectroscopy from the Shane Kast Double Spectrograph at Lick Observatory. We find that the double-peaked emission lines in our sample of 12 candidates are caused by: one dual AGN (SDSS J114642.47+511029.6), one confirmed outflow and four likely outflows, two pairs of star-forming galaxies, one candidate indeterminate due to sky line interference, and three AGNs with spatially coincident double [O iii] peaks, likely due to unresolved complex narrow line kinematics, outflows, binary AGN, or small-scale jets

Analysis of PGY-1 Pharmacy Resident Candidate Letters of Recommendation at an Academically Affiliated Residency Program.

Science.gov (United States)

McLaughlin, Milena M; Masic, Dalila; Gettig, Jacob P

2018-04-01

Letters of recommendation (LORs) are a critical component for differentiating among similarly qualified pharmacy residency candidates. These letters contain information that is difficult to ascertain from curricula vitae and pharmacy school transcripts. LOR writers may use any words or phrases appropriate for each candidate as there is no set framework for LORs. The objective of this study was to characterize descriptive themes in postgraduate year 1 (PGY-1) pharmacy residency candidates' LORs and to examine which themes of PGY-1 pharmacy residency candidates' LORs are predictive of an interview invitation at an academically affiliated residency program. LORs for candidates from the Pharmacy Online Residency Centralized Application System (PhORCAS) from 2013 and 2014 for the Midwestern University PGY-1 Pharmacy Residency were analyzed. LOR characteristics and descriptive themes were collected. All scores for candidate characteristics and overall PhORCAS recommendation were also recorded. A total of 351 LORs for 111 candidates from 2013 (n = 47 candidates) and 2014 (n = 64 candidates) were analyzed; 36 (32.4%) total candidates were offered an interview. Themes that were identified as predictors of an interview included a higher median (interquartile range) number of standout words (3 words [1.3-4] vs 3.8 words [2.5-5.5], P < .01) and teaching references (3.7 words [2.7-6] vs 5.7 words [3.7-7.8], P = .01). For this residency program, standout words and teaching references were important when offering interviews.

11 CFR 9003.2 - Candidate certifications.

Science.gov (United States)

2010-01-01

... funds under 11 CFR 9003.2(c)(3) shall not count against such candidate's $50,000 expenditure limitation... expenditures. (8) Expenditures made using a credit card for which the candidate is jointly or solely liable will count against the limits of this section to the extent that the full amount due, including any...

Psychometric Personality Differences Between Candidates in Astronaut Selection.

Science.gov (United States)

Mittelstädt, Justin M; Pecena, Yvonne; Oubaid, Viktor; Maschke, Peter

This paper investigates personality traits as potential factors for success in an astronaut selection by comparing personality profiles of unsuccessful and successful astronaut candidates in different phases of the ESA selection procedure. It is further addressed whether personality traits could predict an overall assessment rating at the end of the selection. In 2008/2009, ESA performed an astronaut selection with 902 candidates who were either psychologically recommended for mission training (N = 46) or failed in basic aptitude (N = 710) or Assessment Center and interview testing (N = 146). Candidates completed the Temperament Structure Scales (TSS) and the NEO Personality Inventory Revised (NEO-PI-R). Those candidates who failed in basic aptitude testing showed higher levels of Neuroticism (M = 49.8) than the candidates who passed that phase (M = 45.4 and M = 41.6). Additionally, candidates who failed in basic testing had lower levels of Agreeableness (M = 132.9) than recommended candidates (M = 138.1). TSS scales for Achievement (r = 0.19) and Vitality (r = 0.18) showed a significant correlation with the overall assessment rating given by a panel board after a final interview. Results indicate that a personality profile similar to Helmreich's "Right Stuff" is beneficial in astronaut selection. Influences of test anxiety on performance are discussed. Mittelstädt JM, Pecena Y, Oubaid V, Maschke P. Psychometric personality differences between candidates in astronaut selection. Aerosp Med Hum Perform. 2016; 87(11):933-939.

Strategic Entry and the Relationship between Number of Independent and Non-Independent Candidates: A Study of Parliamentary Elections in India

OpenAIRE

Bhattacharya, Kaushik

2011-01-01

The paper attempts to examine the nature and the extent of strategic entries of independent candidates in elections following FPTP rule. The paper observes that besides individual incentives of the candidates, a major factor behind the emergence of independents under FPTP systems could be the surreptitious strategic floating of such candidates by major political parties. Accordingly, the paper proposes to use the number of non-independent candidates in a constituency as a readily observable e...

Seismic review of vault for MFTF upgrade project

International Nuclear Information System (INIS)

Franklin, H.A.

1983-01-01

This letter report was prepared in accordance with the scope of work for the preconceptual seismic evaluation of the (α + T) Tandem Mirror Fusion Machine concrete vault. The scope of the work was developed with the assistance of the Bechtel site representative Dr. Sunil Ghose. The report contains comments and preconceptual recommendations on wall upgrading for an 150-ton crane installation, concrete vault seismic capability for (α + T) conditions, and recommendations for future work

Planetary Candidates Observed by Kepler, III: Analysis of the First 16 Months of Data

Energy Technology Data Exchange (ETDEWEB)

Batalha, Natalie M.; /San Jose State U.; Rowe, Jason F.; /NASA, Ames; Bryson, Stephen T.; /NASA, Ames; Barclay, Thomas; /NASA, Ames; Burke, Christopher J.; /NASA, Ames; Caldwell, Douglas A.; /NASA, Ames; Christiansen, Jessie L.; /NASA, Ames; Mullally, Fergal; /NASA, Ames; Thompson, Susan E.; /NASA, Ames; Brown, Timothy M.; /Las Cumbres Observ.; Dupree, Andrea K.; /Harvard-Smithsonian Ctr. Astrophys. /UC, Santa Cruz

2012-02-01

New transiting planet candidates are identified in sixteen months (May 2009 - September 2010) of data from the Kepler spacecraft. Nearly five thousand periodic transit-like signals are vetted against astrophysical and instrumental false positives yielding 1091 viable new planet candidates, bringing the total count up to over 2,300. Improved vetting metrics are employed, contributing to higher catalog reliability. Most notable is the noise-weighted robust averaging of multiquarter photo-center offsets derived from difference image analysis which identifies likely background eclipsing binaries. Twenty-two months of photometry are used for the purpose of characterizing each of the new candidates. Ephemerides (transit epoch, T{sub 0}, and orbital period, P) are tabulated as well as the products of light curve modeling: reduced radius (R{sub P}/R{sub {star}}), reduced semi-major axis (d/R{sub {star}}), and impact parameter (b). The largest fractional increases are seen for the smallest planet candidates (197% for candidates smaller than 2R{sub {circle_plus}} compared to 52% for candidates larger than 2R{sub {circle_plus}}) and those at longer orbital periods (123% for candidates outside of 50 day orbits versus 85% for candidates inside of 50 day orbits). The gains are larger than expected from increasing the observing window from thirteen months (Quarter 1 - Quarter 5) to sixteen months (Quarter 1 - Quarter 6). This demonstrates the benefit of continued development of pipeline analysis software. The fraction of all host stars with multiple candidates has grown from 17% to 20%, and the paucity of short-period giant planets in multiple systems is still evident. The progression toward smaller planets at longer orbital periods with each new catalog release suggests that Earth-size planets in the Habitable Zone are forthcoming if, indeed, such planets are abundant.

PEACE: pulsar evaluation algorithm for candidate extraction - a software package for post-analysis processing of pulsar survey candidates

NARCIS (Netherlands)

Lee, K.J.; Stovall, K.; Jenet, F.A.; Martinez, J.; Dartez, L.P.; Mata, A.; Lunsford, G.; Cohen, S.; Biwer, C.M.; Rohr, M.; Flanigan, J.; Walker, A.; Banaszak, S.; Allen, B.; Barr, E.D.; Bhat, N.D.R.; Bogdanov, S.; Brazier, A.; Camilo, F.; Champion, D.J.; Chatterjee, S.; Cordes, J.; Crawford, F.; Deneva, J.; Desvignes, G.; Ferdman, R.D.; Freire, P.; Hessels, J.W.T.; Karuppusamy, R.; Kaspi, V.M.; Knispel, B.; Kramer, M.; Lazarus, P.; Lynch, R.; Lyne, A.; McLaughlin, M.; Ransom, S.; Scholz, P.; Siemens, X.; Spitler, L.; Stairs, I.; Tan, M.; van Leeuwen, J.; Zhu, W.W.

2013-01-01

Modern radio pulsar surveys produce a large volume of prospective candidates, the majority of which are polluted by human-created radio frequency interference or other forms of noise. Typically, large numbers of candidates need to be visually inspected in order to determine if they are real pulsars.

Characterization of Gene Candidates for Vacuolar Sodium Transport from Hordeum Vulgare

KAUST Repository

Scheu, Arne Hagen August

2017-01-01

Various potential causes are discussed, including inaccuracies in the genome resource used as reference for primer design and issues inherent to the model system. Finally, I make suggestions on how to proceed to further characterize the candidate genes and hopefully identify novel sodium transporters from barley.

Elections, Information, and State-Dependent Candidate Quality

DEFF Research Database (Denmark)

Jensen, Thomas

voters are uncertain about the state. Candidates are fully informed and completely office-motivated. With a reasonable restriction on voters' beliefs, an equilibrium where candidates' positions reveal the true state does not exist. Non-revealing equilibria always exist. Some main findings...

Candidate Gense of Juvenile Hypertension in the Region of the Major Histo-Compatibility System

Czech Academy of Sciences Publication Activity Database

Mazura, I.; Nutsu-Mazura, F.; Bláha, P.; Bendlová, B.; Včelák, J.; Palyzová, D.; Zvárová, Jana

2002-01-01

Roč. 26, suppl. 1 (2002), s. 84 ISSN 0307-0565. [International Congress on Obesity /9./. 24.08.2002-29.08.2002, Sao Paulo] R&D Projects: GA MZd NB6635; GA MŠk LN00B107 Keywords : juvenile hypertension * candidate genes * statistics Subject RIV: BB - Applied Statistics, Operational Research

French presidential election: nuclear energy in candidates' program

International Nuclear Information System (INIS)

Le Ngoc, B.

2017-01-01

Generally right candidates consider nuclear energy as a chance for France because it is an industrial asset for the country, it releases no greenhouse gases and has given France its large energy independence. They are ready to reconsider the limitation imposed on the share of nuclear energy in the future energy mix and they want to reinforce research for next generations of reactors. The far-right candidate wishes to use nuclear energy massively to produce hydrogen in order to reduce by half the consumption of fossil energies in 20 years. Generally left candidates back the law on the energy transition that was passed during last legislature and that limits the nuclear power share to 50% while developing green energies. The far-left candidates wish a progressive and complete abandon of nuclear energy. All candidates wish a greater share of renewable energies in the future energy mix. (A.C.)

Indico CONFERENCE: Candidate participant's registration/application

CERN Multimedia

CERN. Geneva; Ferreira, Pedro

2017-01-01

In this tutorial you are going to learn how to apply as a candidate participant (if the event requires approval from the event manager) or to register (if participation to the event doesn't require approval from an event manager) to the conference using the registration form for the event. You are also going to learn how to approve a candidate participant's application as an event manager.

NHI economic analysis of candidate nuclear hydrogen processes

International Nuclear Information System (INIS)

Allen, D.; Pickard, P.; Patterson, M.; Sink, C.

2010-01-01

The DOE Nuclear Hydrogen Initiative (NHI) is investigating candidate technologies for large scale hydrogen production using high temperature gas-cooled reactors (HTGR) in concert with the Next Generation Nuclear Plant (NGNP) programme. The candidate processes include high temperature thermochemical and high temperature electrolytic processes which are being investigated in a sequence of experimental and analytic studies to establish the most promising and cost effective means of hydrogen production with nuclear energy. Although these advanced processes are in an early development stage, it is important that the projected economic potential of these processes be evaluated to assist in the prioritisation of research activities, and ultimately in the selection of the most promising processes for demonstration and deployment. The projected cost of hydrogen produced is the most comprehensive metric in comparing candidate processes. Since these advanced processes are in the early stages of development and much of the technology is still unproven, the estimated production costs are also significantly uncertain. The programme approach has been to estimate the cost of hydrogen production from each process periodically, based on the best available data at that time, with the intent of increasing fidelity and reducing uncertainty as the research programme and system definition studies progress. These updated cost estimates establish comparative costs at that stage of development but are also used as inputs to the evaluation of research priorities, and identify the key cost and risk (uncertainty) drivers for each process. The economic methodology used to assess the candidate processes are based on the H2A ground rules and modelling tool (discounted cash flow) developed by the DOE Office of Energy Efficiency and Renewable Energy (EERE). The figure of merit output from the calculation is the necessary selling price for hydrogen in dollars per kilogram that satisfies the cost

Developing Potential Candidates of Preclinical Preeclampsia

Directory of Open Access Journals (Sweden)

Sandra Founds

2015-11-01

Full Text Available The potential for developing molecules of interest in preclinical preeclampsia from candidate genes that were discovered on gene expression microarray analysis has been challenged by limited access to additional first trimester trophoblast and decidual tissues. The question of whether these candidates encode secreted proteins that may be detected in maternal circulation early in pregnancy has been investigated using various proteomic methods. Pilot studies utilizing mass spectrometry based proteomic assays, along with enzyme linked immunosorbent assays (ELISAs, and Western immunoblotting in first trimester samples are reported. The novel targeted mass spectrometry methods led to robust multiple reaction monitoring assays. Despite detection of several candidates in early gestation, challenges persist. Future antibody-based studies may lead to a novel multiplex protein panel for screening or detection to prevent or mitigate preeclampsia.

PLANETARY CANDIDATES OBSERVED BY KEPLER IV: PLANET SAMPLE FROM Q1-Q8 (22 MONTHS)

International Nuclear Information System (INIS)

Burke, Christopher J.; Mullally, F.; Rowe, Jason F.; Thompson, Susan E.; Coughlin, Jeffrey L.; Caldwell, Douglas A.; Jenkins, Jon M.; Bryson, Stephen T.; Haas, Michael R.; Batalha, Natalie M.; Borucki, William J.; Christiansen, Jessie L.; Ciardi, David R.; Still, Martin; Barclay, Thomas; Chaplin, William J.; Clarke, Bruce D.; Cochran, William D.; Demory, Brice-Olivier; Esquerdo, Gilbert A.

2014-01-01

We provide updates to the Kepler planet candidate sample based upon nearly two years of high-precision photometry (i.e., Q1-Q8). From an initial list of nearly 13,400 threshold crossing events, 480 new host stars are identified from their flux time series as consistent with hosting transiting planets. Potential transit signals are subjected to further analysis using the pixel-level data, which allows background eclipsing binaries to be identified through small image position shifts during transit. We also re-evaluate Kepler Objects of Interest (KOIs) 1-1609, which were identified early in the mission, using substantially more data to test for background false positives and to find additional multiple systems. Combining the new and previous KOI samples, we provide updated parameters for 2738 Kepler planet candidates distributed across 2017 host stars. From the combined Kepler planet candidates, 472 are new from the Q1-Q8 data examined in this study. The new Kepler planet candidates represent ∼40% of the sample with R P ∼ 1 R ⊕ and represent ∼40% of the low equilibrium temperature (T eq < 300 K) sample. We review the known biases in the current sample of Kepler planet candidates relevant to evaluating planet population statistics with the current Kepler planet candidate sample

An annotated history of container candidate material selection

International Nuclear Information System (INIS)

McCright, R.D.

1988-07-01

This paper documents events in the Nevada Nuclear Waste Storage Investigations (NNWSI) Project that have influenced the selection of metals and alloys proposed for fabrication of waste package containers for permanent disposal of high-level nuclear waste in a repository at Yucca Mountain, Nevada. The time period from 1981 to 1988 is covered in this annotated history. The history traces the candidate materials that have been considered at different stages of site characterization planning activities. At present, six candidate materials are considered and described in the 1988 Consultation Draft of the NNWSI Site Characterization Plan (SCP). The six materials are grouped into two alloy families, copper-base materials and iron to nickel-base materials with an austenitic structure. The three austenitic candidates resulted from a 1983 survey of a longer list of candidate materials; the other three candidates resulted from a special request from DOE in 1984 to evaluate copper and copper-base alloys. 24 refs., 2 tabs

USING STELLAR DENSITIES TO EVALUATE TRANSITING EXOPLANETARY CANDIDATES

International Nuclear Information System (INIS)

Tingley, B.; Deeg, H. J.; Bonomo, A. S.

2011-01-01

One of the persistent complications in searches for transiting exoplanets is the low percentage of the detected candidates that ultimately prove to be planets, which significantly increases the load on the telescopes used for the follow-up observations to confirm or reject candidates. Several attempts have been made at creating techniques that can pare down candidate lists without the need of additional observations. Some of these techniques involve a detailed analysis of light curve characteristics; others estimate the stellar density or some proxy thereof. In this paper, we extend upon this second approach, exploring the use of independently calculated stellar densities to identify the most promising transiting exoplanet candidates. We use a set of CoRoT candidates and the set of known transiting exoplanets to examine the potential of this approach. In particular, we note the possibilities inherent in the high-precision photometry from space missions, which can detect stellar asteroseismic pulsations from which accurate stellar densities can be extracted without additional observations.

Examination of the Attitudes of Preschool Teacher Candidates and Teacher Candidates in Other Branches towards Scientific Research in Terms of Some Variables

Science.gov (United States)

Ekici, Fatma Yasar

2017-01-01

The main objective of this study is to examine the attitudes of preschool teacher candidates and teacher candidates in other branches towards scientific research in terms of some variables. Survey method was used. The study group consists of 547 teacher candidates studying in education faculty of a private university in the spring term of…

Elemental abundances of solar sibling candidates

International Nuclear Information System (INIS)

Ramírez, I.; Lambert, D. L.; Endl, M.; Cochran, W. D.; MacQueen, P. J.; Bajkova, A. T.; Bobylev, V. V.; Roederer, I. U.; Wittenmyer, R. A.

2014-01-01

Dynamical information along with survey data on metallicity and in some cases age have been used recently by some authors to search for candidates of stars that were born in the cluster where the Sun formed. We have acquired high-resolution, high signal-to-noise ratio spectra for 30 of these objects to determine, using detailed elemental abundance analysis, if they could be true solar siblings. Only two of the candidates are found to have solar chemical composition. Updated modeling of the stars' past orbits in a realistic Galactic potential reveals that one of them, HD 162826, satisfies both chemical and dynamical conditions for being a sibling of the Sun. Measurements of rare-element abundances for this star further confirm its solar composition, with the only possible exception of Sm. Analysis of long-term high-precision radial velocity data rules out the presence of hot Jupiters and confirms that this star is not in a binary system. We find that chemical tagging does not necessarily benefit from studying as many elements as possible but instead from identifying and carefully measuring the abundances of those elements that show large star-to-star scatter at a given metallicity. Future searches employing data products from ongoing massive astrometric and spectroscopic surveys can be optimized by acknowledging this fact.

Cancer in silico drug discovery: a systems biology tool for identifying candidate drugs to target specific molecular tumor subtypes.

Science.gov (United States)

San Lucas, F Anthony; Fowler, Jerry; Chang, Kyle; Kopetz, Scott; Vilar, Eduardo; Scheet, Paul

2014-12-01

Large-scale cancer datasets such as The Cancer Genome Atlas (TCGA) allow researchers to profile tumors based on a wide range of clinical and molecular characteristics. Subsequently, TCGA-derived gene expression profiles can be analyzed with the Connectivity Map (CMap) to find candidate drugs to target tumors with specific clinical phenotypes or molecular characteristics. This represents a powerful computational approach for candidate drug identification, but due to the complexity of TCGA and technology differences between CMap and TCGA experiments, such analyses are challenging to conduct and reproduce. We present Cancer in silico Drug Discovery (CiDD; scheet.org/software), a computational drug discovery platform that addresses these challenges. CiDD integrates data from TCGA, CMap, and Cancer Cell Line Encyclopedia (CCLE) to perform computational drug discovery experiments, generating hypotheses for the following three general problems: (i) determining whether specific clinical phenotypes or molecular characteristics are associated with unique gene expression signatures; (ii) finding candidate drugs to repress these expression signatures; and (iii) identifying cell lines that resemble the tumors being studied for subsequent in vitro experiments. The primary input to CiDD is a clinical or molecular characteristic. The output is a biologically annotated list of candidate drugs and a list of cell lines for in vitro experimentation. We applied CiDD to identify candidate drugs to treat colorectal cancers harboring mutations in BRAF. CiDD identified EGFR and proteasome inhibitors, while proposing five cell lines for in vitro testing. CiDD facilitates phenotype-driven, systematic drug discovery based on clinical and molecular data from TCGA. ©2014 American Association for Cancer Research.

Surface Catalytic Efficiency of Advanced Carbon Carbon Candidate Thermal Protection Materials for SSTO Vehicles

Science.gov (United States)

Stewart, David A.

1996-01-01

The catalytic efficiency (atom recombination coefficients) for advanced ceramic thermal protection systems was calculated using arc-jet data. Coefficients for both oxygen and nitrogen atom recombination on the surfaces of these systems were obtained to temperatures of 1650 K. Optical and chemical stability of the candidate systems to the high energy hypersonic flow was also demonstrated during these tests.

PEACE: pulsar evaluation algorithm for candidate extraction - a software package for post-analysis processing of pulsar survey candidates

Science.gov (United States)

Lee, K. J.; Stovall, K.; Jenet, F. A.; Martinez, J.; Dartez, L. P.; Mata, A.; Lunsford, G.; Cohen, S.; Biwer, C. M.; Rohr, M.; Flanigan, J.; Walker, A.; Banaszak, S.; Allen, B.; Barr, E. D.; Bhat, N. D. R.; Bogdanov, S.; Brazier, A.; Camilo, F.; Champion, D. J.; Chatterjee, S.; Cordes, J.; Crawford, F.; Deneva, J.; Desvignes, G.; Ferdman, R. D.; Freire, P.; Hessels, J. W. T.; Karuppusamy, R.; Kaspi, V. M.; Knispel, B.; Kramer, M.; Lazarus, P.; Lynch, R.; Lyne, A.; McLaughlin, M.; Ransom, S.; Scholz, P.; Siemens, X.; Spitler, L.; Stairs, I.; Tan, M.; van Leeuwen, J.; Zhu, W. W.

2013-07-01

Modern radio pulsar surveys produce a large volume of prospective candidates, the majority of which are polluted by human-created radio frequency interference or other forms of noise. Typically, large numbers of candidates need to be visually inspected in order to determine if they are real pulsars. This process can be labour intensive. In this paper, we introduce an algorithm called Pulsar Evaluation Algorithm for Candidate Extraction (PEACE) which improves the efficiency of identifying pulsar signals. The algorithm ranks the candidates based on a score function. Unlike popular machine-learning-based algorithms, no prior training data sets are required. This algorithm has been applied to data from several large-scale radio pulsar surveys. Using the human-based ranking results generated by students in the Arecibo Remote Command Center programme, the statistical performance of PEACE was evaluated. It was found that PEACE ranked 68 per cent of the student-identified pulsars within the top 0.17 per cent of sorted candidates, 95 per cent within the top 0.34 per cent and 100 per cent within the top 3.7 per cent. This clearly demonstrates that PEACE significantly increases the pulsar identification rate by a factor of about 50 to 1000. To date, PEACE has been directly responsible for the discovery of 47 new pulsars, 5 of which are millisecond pulsars that may be useful for pulsar timing based gravitational-wave detection projects.

Evaluation of candidate geomagnetic field models for IGRF-11

DEFF Research Database (Denmark)

Finlay, Chris; Maus, S.; Beggan, C. D.

2010-01-01

variations between candidates originate. A retrospective analysis of IGRF-10 main field candidates for epoch 2005.0 and predictive secular variation candidates for 2005.0–2010.0 using the new IGRF-11 models as a reference is also reported. The high quality and consistency of main field models derived using...

Process modeling for the Integrated Thermal Treatment System (ITTS) study

Energy Technology Data Exchange (ETDEWEB)

Liebelt, K.H.; Brown, B.W.; Quapp, W.J.

1995-09-01

This report describes the process modeling done in support of the integrated thermal treatment system (ITTS) study, Phases 1 and 2. ITTS consists of an integrated systems engineering approach for uniform comparison of widely varying thermal treatment technologies proposed for treatment of the contact-handled mixed low-level wastes (MLLW) currently stored in the U.S. Department of Energy complex. In the overall study, 19 systems were evaluated. Preconceptual designs were developed that included all of the various subsystems necessary for a complete installation, from waste receiving through to primary and secondary stabilization and disposal of the processed wastes. Each system included the necessary auxiliary treatment subsystems so that all of the waste categories in the complex were fully processed. The objective of the modeling task was to perform mass and energy balances of the major material components in each system. Modeling of trace materials, such as pollutants and radioactive isotopes, were beyond the present scope. The modeling of the main and secondary thermal treatment, air pollution control, and metal melting subsystems was done using the ASPEN PLUS process simulation code, Version 9.1-3. These results were combined with calculations for the remainder of the subsystems to achieve the final results, which included offgas volumes, and mass and volume waste reduction ratios.

Process modeling for the Integrated Thermal Treatment System (ITTS) study

International Nuclear Information System (INIS)

Liebelt, K.H.; Brown, B.W.; Quapp, W.J.

1995-09-01

This report describes the process modeling done in support of the integrated thermal treatment system (ITTS) study, Phases 1 and 2. ITTS consists of an integrated systems engineering approach for uniform comparison of widely varying thermal treatment technologies proposed for treatment of the contact-handled mixed low-level wastes (MLLW) currently stored in the U.S. Department of Energy complex. In the overall study, 19 systems were evaluated. Preconceptual designs were developed that included all of the various subsystems necessary for a complete installation, from waste receiving through to primary and secondary stabilization and disposal of the processed wastes. Each system included the necessary auxiliary treatment subsystems so that all of the waste categories in the complex were fully processed. The objective of the modeling task was to perform mass and energy balances of the major material components in each system. Modeling of trace materials, such as pollutants and radioactive isotopes, were beyond the present scope. The modeling of the main and secondary thermal treatment, air pollution control, and metal melting subsystems was done using the ASPEN PLUS process simulation code, Version 9.1-3. These results were combined with calculations for the remainder of the subsystems to achieve the final results, which included offgas volumes, and mass and volume waste reduction ratios

Regional Autonomy and Local Democracy: Independent Candidates Cases

Directory of Open Access Journals (Sweden)

Suryanto

2016-11-01

Full Text Available One of the efforts to achieve local democracy is through the participation of independent candidates in the Direct General Election in the region. The presence of independent candidates in the Direct General Election gives a great hope to change the political structure of the shackles of the old forces. This paper aims to discuss the implication of regional heads coming from independent candidates on the effectiveness of local governance and the implementation of substantive democracy in the region. The method used is a qualitative approach using descriptive research method. The data collection is done through literature approach. Processing data uses Milles and Huberman interactive models, which includes data reduction, data presentation, and conclusion. The study concluded three things: First, the presence of independent candidates in the Direct General Election gives the opportunities to achieve local democracy that is getting bigger, Second, Regional Heads elected from independent candidates face the challenges of the ineffectiveness of regional government, and Third, within certain limits, the power of elected regional heads from independent lane leads to the realization of democracy that is not substantial.

Physical attractiveness, issue agreement, and assimilation effects in candidate appraisal.

Science.gov (United States)

Schubert, James N; Curran, Margaret Ann; Strungaru, Carmen

2011-01-01

This study examines the cognitive and affective factors of candidate appraisal by manipulating candidate attractiveness and levels of issue agreement with voters. Drawing upon research in evolutionary psychology and cognitive neuroscience, this analysis proposes that automatic processing of physical appearance predisposes affective disposition toward more attractive candidates, thereby influencing cognitive processing of issue information. An experimental design presented attractive and unattractive candidates who were either liberal or conservative in a mock primary election. The data show strong partial effects for appearance on vote intention, an interaction between appearance and issue agreement, and a tendency for voters to assimilate the dissimilar views of attractive candidates. We argue that physical appearance is important in primary elections when the differences in issue positions and ideology between candidates is small.

Ensemble candidate classification for the LOTAAS pulsar survey

Science.gov (United States)

Tan, C. M.; Lyon, R. J.; Stappers, B. W.; Cooper, S.; Hessels, J. W. T.; Kondratiev, V. I.; Michilli, D.; Sanidas, S.

2018-03-01

One of the biggest challenges arising from modern large-scale pulsar surveys is the number of candidates generated. Here, we implemented several improvements to the machine learning (ML) classifier previously used by the LOFAR Tied-Array All-Sky Survey (LOTAAS) to look for new pulsars via filtering the candidates obtained during periodicity searches. To assist the ML algorithm, we have introduced new features which capture the frequency and time evolution of the signal and improved the signal-to-noise calculation accounting for broad profiles. We enhanced the ML classifier by including a third class characterizing RFI instances, allowing candidates arising from RFI to be isolated, reducing the false positive return rate. We also introduced a new training data set used by the ML algorithm that includes a large sample of pulsars misclassified by the previous classifier. Lastly, we developed an ensemble classifier comprised of five different Decision Trees. Taken together these updates improve the pulsar recall rate by 2.5 per cent, while also improving the ability to identify pulsars with wide pulse profiles, often misclassified by the previous classifier. The new ensemble classifier is also able to reduce the percentage of false positive candidates identified from each LOTAAS pointing from 2.5 per cent (˜500 candidates) to 1.1 per cent (˜220 candidates).

Opinions of the Geography Teacher Candidates toward Mind Maps

Science.gov (United States)

Seyihoglu, Aysegul

2013-01-01

The purpose of this study is to reveal the opinions of the teacher candidates about mind mapping technique used in Geography education of undergraduate program. In this study, the qualitative research techniques were used. The study group consists of 55 teacher candidates. The teacher candidates have been asked for their opinions about the process…

Candidate Binary Trojan and Hilda Asteroids from Rotational Light Curves

Science.gov (United States)

Sonnett, Sarah M.; Mainzer, Amy K.; Grav, Tommy; Masiero, Joseph R.; Bauer, James M.; Kramer, Emily A.

2017-10-01

Jovian Trojans (hereafter, Trojans) are asteroids in stable orbits at Jupiter's L4 and L5 Lagrange points, and Hilda asteroids are inwards of the Trojans in 3:2 mean-motion resonance with Jupiter. Due to their special dynamical properties, observationally constraining the formation location and dynamical histories of Trojans and HIldas offers key input for giant planet migration models. A fundamental parameter in assessing formation location is the bulk density - with low-density objects associated with an ice-rich formation environment in the outer solar system and high-density objects typically linked to the warmer inner solar system. Bulk density can only be directly measured during a close fly-by or by determining the mutual orbits of binary asteroid systems. With the aim of determining densities for a statistically significant sample of Trojans and Hildas, we are undertaking an observational campaign to confirm and characterize candidate binary asteroids published in Sonnett et al. (2015). These objects were flagged as binary candidates because their large NEOWISE brightness variations imply shapes so elongated that they are not likely explained by a singular equilibrium rubble pile and instead may be two elongated, gravitationally bound asteroids. We are obtaining densely sampled rotational light curves of these possible binaries to search for light curve features diagnostic of binarity and to determine the orbital properties of any confirmed binary systems by modeling the light curve. We compare the We present an update on this follow-up campaign and comment on future steps.

Do People 'Like' Candidates on Facebook?

DEFF Research Database (Denmark)

Nielsen, Rasmus Kleis

The online popularity of a few exceptional candidates has led many to suggest that social media have given politicians powerful ways of communicating directly with voters. In this paper, we examine whether this is happening on a significant scale and show, based on analysis of 224 candidates....... We therefore suggest that the political implications of social media are generally better understood in terms of facilitating indirect communication and institutional change than in terms of direct communication....

Commercial nuclear waste repository in basalt

International Nuclear Information System (INIS)

Hardy, M.P.; Patricio, J.G.; Heley, W.H.

1980-06-01

The Basalt Waste Isolation Project (BWIP) is an ongoing research and engineering effort being conducted by Rockwell Hanford Operations (Rockwell), which is under contract to the US Department of Energy. The objectives of this program are to assess the feasibility of and to provide the technology needed to design and construct a licensed commercial nuclear waste repository in the deep basalt formations underlying the Hanford Site. An extensive preconceptual design effort was undertaken during 1979 to develop a feasible concept that could serve as a reference design for both surface and underground facilities. The preconceptual design utilized existing technology to the greatest extent possible to offer a system design that could be utilized in establishing schedule and cost baseline data, recommend alternatives that require additional study, and develop basic design requirements that would allow evolution of the design process prior to the existence of legislated criteria. This paper provides a description of the concept developed for the subsurface aspects of this nuclear waste repository

Thermal characteristics of non-edible oils as phase change materials candidate to application of air conditioning chilled water system

Science.gov (United States)

Irsyad, M.; Indartono, Y. S.; Suwono, A.; Pasek, A. D.

2015-09-01

The addition of phase change material in the secondary refrigerant has been able to reduce the energy consumption of air conditioning systems in chilled water system. This material has a high thermal density because its energy is stored as latent heat. Based on material melting and freezing point, there are several non-edible oils that can be studied as a phase change material candidate for the application of chilled water systems. Forests and plantations in Indonesia have great potential to produce non-edible oil derived from the seeds of the plant, such as; Calophyllum inophyllum, Jatropha curcas L, and Hevea braziliensis. Based on the melting temperature, these oils can further studied to be used as material mixing in the secondary refrigerant. Thermal characteristics are obtained from the testing of T-history, Differential Scanning Calorimetric (DSC) and thermal conductivity materials. Test results showed an increase in the value of the latent heat when mixed with water with the addition of surfactant. Thermal characteristics of each material of the test results are shown completely in discussion section of this article.

Pre-conceptual design of the Z-LLE accelerator.

Energy Technology Data Exchange (ETDEWEB)

Stygar, William A. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

2016-11-01

We begin with a model of 20 LTD modules, connected in parallel. We assume each LTD module consists of 10 LTD cavities, connected in series. We assume each cavity includes 20 LTD bricks, in parallel. Each brick is assumed to have a 40-nF capacitance and a 160-nH inductance. We use for this calculation the RLC-circuit model of an LTD system that was developed by Mazarakis and colleagues.

A possible candidate for cold dark matter

Indian Academy of Sciences (India)

This additional scalar can be a viable candidate of cold dark matter (CDM) since the stability of is achieved by the application of Z 2 symmetry on . Considering as a possible candidate of CDM, Boltzmann's equation is solved to find the freeze-out temperature and relic density of for Higgs mass 120 GeV in the scalar ...

Neural stem/progenitor cells as a promising candidate for regenerative therapy of the central nervous system

Directory of Open Access Journals (Sweden)

Virginie eBonnamain

2012-04-01

Full Text Available Neural transplantation is a promising therapeutic strategy for neurodegenerative diseases and other affections of the central nervous system (CNS like Parkinson and Huntington diseases, multiple sclerosis or stroke. If cell replacement therapy already went through clinical trials for some of these diseases using fetal human neuroblasts, several important limitations led to the search for alternative cell sources that would be more suitable for intracerebral transplantation. Taking into account logistical and ethical issues linked to the use of tissue derived from human fetuses, and the immunologically special status of the CNS allowing the occurrence of deleterious immune reactions, Neural Stem/Progenitor Cells (NSPCs appear as an interesting cell source candidate. In addition to their ability for replacing cell populations lost during the pathological events, NSPCs also display surprising therapeutic effects of neuroprotection and immunomodulation. A better knowledge of the mechanisms involved in these specific characteristics will hopefully lead in the future to a successful use of NSPCs in regenerative medicine for CNS affections.

SDSS-III MARVELS Planet Candidate RV Follow-up

Science.gov (United States)

Ge, Jian; Thomas, Neil; Ma, Bo; Li, Rui; SIthajan, Sirinrat

2014-02-01

Planetary systems, discovered by the radial velocity (RV) surveys, reveal strong correlations between the planet frequency and stellar properties, such as metallicity and mass, and a greater diversity in planets than found in the solar system. However, due to the sample sizes of extant surveys (~100 to a few hundreds of stars) and their heterogeneity, many key questions remained to be addressed: Do metal poor stars obey the same trends for planet occurrence as metal rich stars? What is the distribution of giant planets around intermediate- mass stars and binaries? Is the ``planet desert'' within 0.6 AU in the planet orbital distribution of intermediate-mass stars real? The MARVELS survey has produced the largest homogeneous RV measurements of 3300 V=7.6-12 FGK stars. The latest data pipeline effort at UF has been able to remove long term systematic errors suffered in the earlier data pipeline. 18 high confident giant planet candidates have been identified among newly processed data. We propose to follow up these giant planet candidates with the KPNO EXPERT instrument to confirm the detection and also characterize their orbits. The confirmed planets will be used to measure occurrence rates, distributions and multiplicity of giants planets around F,G,K stars with a broad range of mass (~0.6-2.5 M_⊙) and metallicity ([Fe/H]~-1.5-0.5). The well defined MARVELS survey cadence allows robust determinations of completeness limits for rigorously testing giant planet formation theories and constraining models.

Candidate Smoke Region Segmentation of Fire Video Based on Rough Set Theory

Directory of Open Access Journals (Sweden)

Yaqin Zhao

2015-01-01

Full Text Available Candidate smoke region segmentation is the key link of smoke video detection; an effective and prompt method of candidate smoke region segmentation plays a significant role in a smoke recognition system. However, the interference of heavy fog and smoke-color moving objects greatly degrades the recognition accuracy. In this paper, a novel method of candidate smoke region segmentation based on rough set theory is presented. First, Kalman filtering is used to update video background in order to exclude the interference of static smoke-color objects, such as blue sky. Second, in RGB color space smoke regions are segmented by defining the upper approximation, lower approximation, and roughness of smoke-color distribution. Finally, in HSV color space small smoke regions are merged by the definition of equivalence relation so as to distinguish smoke images from heavy fog images in terms of V component value variety from center to edge of smoke region. The experimental results on smoke region segmentation demonstrated the effectiveness and usefulness of the proposed scheme.

BINARY CANDIDATES IN THE JOVIAN TROJAN AND HILDA POPULATIONS FROM NEOWISE LIGHT CURVES

Energy Technology Data Exchange (ETDEWEB)

Sonnett, S.; Mainzer, A.; Masiero, J.; Bauer, J. [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109 (United States); Grav, T., E-mail: Sarah.Sonnett@jpl.nasa.gov [Planetary Science Institute, Tucson, AZ (United States)

2015-02-01

Determining the binary fraction for a population of asteroids, particularly as a function of separation between the two components, helps describe the dynamical environment at the time the binaries formed, which in turn offers constraints on the dynamical evolution of the solar system. We searched the NEOWISE archival data set for close and contact binary Trojans and Hildas via their diagnostically large light curve amplitudes. We present 48 out of 554 Hilda and 34 out of 953 Trojan binary candidates in need of follow-up to confirm their large light curve amplitudes and subsequently constrain the binary orbit and component sizes. From these candidates, we calculate a preliminary estimate of the binary fraction without confirmation or debiasing of 14%-23% for Trojans larger than ∼12 km and 30%-51% for Hildas larger than ∼4 km. Once the binary candidates have been confirmed, it should be possible to infer the underlying, debiased binary fraction through estimation of survey biases.

Holmes versus Traditional Teacher Candidates: Labor Market Receptivity.

Science.gov (United States)

Young, I. Phillip; And Others

1997-01-01

"Typical" paper credentials were used to create 12 hypothetical teacher candidates. Credential contents were varied to reflect all combinations of college preparatory institutions (Holmes vs. traditional), education degree types, and chronological ages. Randomly selected high school principals then evaluated candidates. Holmes-prepared…

22 CFR 11.20 - Foreign Service specialist career candidate appointments.

Science.gov (United States)

2010-04-01

..., background investigation, and final review process required of career candidates, but normally they will not... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Foreign Service specialist career candidate... SERVICE OFFICERS § 11.20 Foreign Service specialist career candidate appointments. (a) General...

A computer vision based candidate for functional balance test.

Science.gov (United States)

Nalci, Alican; Khodamoradi, Alireza; Balkan, Ozgur; Nahab, Fatta; Garudadri, Harinath

2015-08-01

Balance in humans is a motor skill based on complex multimodal sensing, processing and control. Ability to maintain balance in activities of daily living (ADL) is compromised due to aging, diseases, injuries and environmental factors. Center for Disease Control and Prevention (CDC) estimate of the costs of falls among older adults was $34 billion in 2013 and is expected to reach $54.9 billion in 2020. In this paper, we present a brief review of balance impairments followed by subjective and objective tools currently used in clinical settings for human balance assessment. We propose a novel computer vision (CV) based approach as a candidate for functional balance test. The test will take less than a minute to administer and expected to be objective, repeatable and highly discriminative in quantifying ability to maintain posture and balance. We present an informal study with preliminary data from 10 healthy volunteers, and compare performance with a balance assessment system called BTrackS Balance Assessment Board. Our results show high degree of correlation with BTrackS. The proposed system promises to be a good candidate for objective functional balance tests and warrants further investigations to assess validity in clinical settings, including acute care, long term care and assisted living care facilities. Our long term goals include non-intrusive approaches to assess balance competence during ADL in independent living environments.

Physical education candidate teachers' beliefs about vocational self-esteem

OpenAIRE

OZSAKER, Murat; CANPOLAT, A. Meliha

2014-01-01

The purpose of this study was to determine epistemological belief and vocational self-esteem physical education candidate teachers of Physical Education and Sports Department in 3 different universities, and also to examine effect of epistemological beliefs on vocational self-esteem. A total of 346 candidate teacher respondents (137 female and 209 male) participated in the study. Epistemological Beliefs and Vocational Self-Esteem Scale were used to determine candidate teachers’ epistemologica...

Selection of radio pulsar candidates using artificial neural networks

OpenAIRE

Eatough, R. P.; Molkenthin, N.; Kramer, M.; Noutsos, A.; Keith, M. J.; Stappers, B. W.; Lyne, A. G.

2010-01-01

Radio pulsar surveys are producing many more pulsar candidates than can be inspected by human experts in a practical length of time. Here we present a technique to automatically identify credible pulsar candidates from pulsar surveys using an artificial neural network. The technique has been applied to candidates from a recent re-analysis of the Parkes multi-beam pulsar survey resulting in the discovery of a previously unidentified pulsar.

Political Candidate Campaign Advertising: A Selected Review of the Literature.

Science.gov (United States)

Hellweg, Susan A.

This paper provides a selected review of political candidate campaign advertising studies from the political science, mass communication, advertising, and political communication literature. The paper examines the literature in terms of research pertaining to (1) candidate advertising content (commercials for male versus female candidates and for…

Cognitive Styles in Admission Procedures for Assessing Candidates of Architecture

Science.gov (United States)

Casakin, Hernan; Gigi, Ariela

2016-01-01

Cognitive style has a strong predictive power in academic and professional success. This study investigated the cognitive profile of candidates studying architecture. Specifically, it explored the relation between visual and verbal cognitive styles, and the performance of candidates in admission procedures. The cognitive styles of candidates who…

Counts of low-Redshift SDSS quasar candidates

International Nuclear Information System (INIS)

Zeljko Ivezic

2004-01-01

We analyze the counts of low-redshift quasar candidates selected using nine-epoch SDSS imaging data. The co-added catalogs are more than 1 mag deeper than single-epoch SDSS data, and allow the selection of low-redshift quasar candidates using UV-excess and also variability techniques. The counts of selected candidates are robustly determined down to g = 21.5. This is about 2 magnitudes deeper than the position of a change in the slope of the counts reported by Boyle (and others) (1990, 2000) for a sample selected by UV-excess, and questioned by Hawkins and Veron (1995), who utilized a variability-selected sample. Using SDSS data, we confirm a change in the slope of the counts for both UV-excess and variability selected samples, providing strong support for the Boyle (and others) results

Views on Values Education: From Teacher Candidates to Experienced Teachers

Science.gov (United States)

Iscan, Canay Demirhan

2015-01-01

This study aimed to identify the views of experienced class teachers and class teacher candidates on values education. It conducted standard open-ended interviews with experienced class teachers and teacher candidates. The study group comprised 9 experienced class teachers from different socio-economic levels and 9 teacher candidates with…

Hydrogen production system based on high temperature gas cooled reactor energy using the sulfur-iodine (SI) thermochemical water splitting cycle

International Nuclear Information System (INIS)

Garcia, L.; Gonzalez, D.

2011-01-01

Hydrogen production from water using nuclear energy offers one of the most attractive zero-emission energy strategies and the only one that is practical on a substantial scale. Recently, strong interest is seen in hydrogen production using heat of a high-temperature gas-cooled reactor. The high-temperature characteristics of the modular helium reactor (MHR) make it a strong candidate for producing hydrogen using thermochemical or high-temperature electrolysis (HTE) processes. Eventually it could be also employ a high-temperature gas-cooled reactor (HTGR), which is particularly attractive because it has unique capability, among potential future generation nuclear power options, to produce high-temperature heat ideally suited for nuclear-heated hydrogen production. Using heat from nuclear reactors to drive a sulfur-iodine (SI) thermochemical hydrogen production process has been interest of many laboratories in the world. One of the promising approaches to produce large quantity of hydrogen in an efficient way using the nuclear energy is the sulfur-iodine (SI) thermochemical water splitting cycle. Among the thermochemical cycles, the sulfur iodine process remains a very promising solution in matter of efficiency and cost. This work provides a pre-conceptual design description of a SI-Based H2-Nuclear Reactor plant. Software based on chemical process simulation (CPS) was used to simulate the thermochemical water splitting cycle Sulfur-Iodine for hydrogen production. (Author)

Modification of MELCOR for severe accident analysis of candidate accident tolerant cladding materials

Energy Technology Data Exchange (ETDEWEB)

Merrill, Brad J., E-mail: brad.merrill@inl.gov; Bragg-Sitton, Shannon M., E-mail: shannon.bragg-sitton@inl.gov; Humrickhouse, Paul W., E-mail: paul.humrickhouse@inl.gov

2017-04-15

Highlights: • Accident tolerant fuels (ATF) systems are currently under development for LWRs. • Many performance analysis tools are specifically developed for UO{sub 2}–Zr alloy fuel. • Modifications were made to the MELCOR code for candidate ATF cladding. • Preliminary analysis results for SiC and FeCrAl cladding concepts are presented. - Abstract: A number of materials are currently under development as candidate accident tolerant fuel and cladding for application in the current fleet of commercial light water reactors (LWRs). The safe, reliable and economic operation of the nation’s nuclear power reactor fleet has always been a top priority for the nuclear industry. Continual improvement of technology, including advanced materials and nuclear fuels, remains central to the industry’s success. Enhancing the accident tolerance of light water reactors became a topic of serious discussion following the 2011 Great East Japan Earthquake, resulting tsunami, and subsequent damage to the Fukushima Daiichi nuclear power plant complex. The overall goal for the development of accident tolerant fuel (ATF) systems for LWRs is to identify alternative fuel system technologies to further enhance the safety, competitiveness, and economics of commercial nuclear power. Designed for use in the current fleet of commercial LWRs, or in reactor concepts with design certifications (GEN-III+), to achieve their goal enhanced ATF must endure loss of active cooling in the reactor core for a considerably longer period of time than the current fuel system, while maintaining or improving performance during normal operation. Many available nuclear fuel performance analysis tools are specifically developed for the current UO{sub 2}–Zirconium alloy fuel system. The MELCOR severe-accident analysis code, under development at the Sandia National Laboratory in New Mexico (SNL-NM) for the US Nuclear Regulatory Commission (NRC), is one of these tools. This paper describes modifications

Hypervelocity star candidates in Gaia DR1/TGAS

Science.gov (United States)

Marchetti, T.; Rossi, E. M.; Kordopatis, G.; Brown, A. G. A.; Rimoldi, A.; Starkenburg, E.; Youakim, K.; Ashley, R.

2018-04-01

Hypervelocity stars (HVSs) are characterized by a total velocity in excess of the Galactic escape speed, and with trajectories consistent with coming from the Galactic Centre. We apply a novel data mining routine, an artificial neural network, to discover HVSs in the TGAS subset of the first data release of the Gaia satellite, using only the astrometry of the stars. We find 80 stars with a predicted probability >90% of being HVSs, and we retrieved radial velocities for 47 of those. We discover 14 objects with a total velocity in the Galactic rest frame >400 km s-1, and 5 of these have a probability >50% of being unbound from the Milky Way. Tracing back orbits in different Galactic potentials, we discover 1 HVS candidate, 5 bound HVS candidates, and 5 runaway star candidates with remarkably high velocities, between 400 and 780 km s-1. We wait for future Gaia releases to confirm the goodness of our sample and to increase the number of HVS candidates.

Candidate genes in panic disorder

DEFF Research Database (Denmark)

Howe, A. S.; Buttenschön, Henriette N; Bani-Fatemi, A.

2016-01-01

The utilization of molecular genetics approaches in examination of panic disorder (PD) has implicated several variants as potential susceptibility factors for panicogenesis. However, the identification of robust PD susceptibility genes has been complicated by phenotypic diversity, underpowered...... association studies and ancestry-specific effects. In the present study, we performed a succinct review of case-control association studies published prior to April 2015. Meta-analyses were performed for candidate gene variants examined in at least three studies using the Cochrane Mantel-Haenszel fixed......-effect model. Secondary analyses were also performed to assess the influences of sex, agoraphobia co-morbidity and ancestry-specific effects on panicogenesis. Meta-analyses were performed on 23 variants in 20 PD candidate genes. Significant associations after correction for multiple testing were observed...

Continuing professional education and the selection of candidates: the case for a tripartite model.

Science.gov (United States)

Ellis, L B

2000-02-01

This paper argues the case for a tripartite model involving the manager educator and practitioner in the selection of candidates to programmes of continuing professional education (CPE). Nurse educators are said to play a key link in the education practice chain (Pendleton & Myles 1991), yet with the introduction of a market philosophy for education, the educator appears to have little, if any, influence over the selection of CPE candidates. Empirical studies on the value of an effective system for identifying the educational needs of the individual and the locality are unequivocal in specifying the benefits of a collaborative selection process (Larcombe & Maggs 1991). However, there are few studies that offer a model of collaboration and fewer still on how to operationalize such a model. This paper presents the policy and legislative context of CPE leading to the development of a market philosophy. The tension between educational reforms such as life-long learning and diminishing and finite resources are highlighted. These strategic issues provide the backdrop and rationale for considering the process for identifying CPE needs, and the characteristics of an effective system as suggested in the literature. Finally, this paper outlines recommendations for a partnership between the manager practitioner and educationalist in the selection of CPE candidates.

Molecular candidates of MTV in air

Science.gov (United States)

Dam, Nico; Mirzaei, Mehrnoosh; van de Water, Willem

2011-11-01

In molecular tagging velocimetry (MTV), the molecules of a gas are used as flow tracers. These tracers can be produced at will by illumination with a laser which promotes molecules to a long- lived excited state, fuses N2 and N2 to NO, or makes molecules phosphoresce. A while later these tagged molecules can be visualized by laser-induced fluorescence, or by just watching them while they phosphoresce. Candidates for MTV in turbulence research must be arranged in structures narrower than the Kolmogorov scale, which remain narrow as time progresses, and must live longer than the Kolmogorov time. These requirements invalidate many candidates, candidates once deemed successful. They do so in various surprising manners that involve a combination of fluid flow and molecular dynamics. Rather than velocimetry in turbulence, MTV techniques offer a unique view on basic dispersion processes at the smallest scales of turbulence. In this way we have measured the spreading of clouds whose size is a few times the Kolmogorov length and the Batchelor dispersion of objects whose size is inside the inertial range.

Computerized detection of multiple sclerosis candidate regions based on a level set method using an artificial neural network

International Nuclear Information System (INIS)

Kuwazuru, Junpei; Magome, Taiki; Arimura, Hidetaka; Yamashita, Yasuo; Oki, Masafumi; Toyofuku, Fukai; Kakeda, Shingo; Yamamoto, Daisuke

2010-01-01

Yamamoto et al. developed the system for computer-aided detection of multiple sclerosis (MS) candidate regions. In a level set method in their proposed method, they employed the constant threshold value for the edge indicator function related to a speed function of the level set method. However, it would be appropriate to adjust the threshold value to each MS candidate region, because the edge magnitudes in MS candidates differ from each other. Our purpose of this study was to develop a computerized detection of MS candidate regions in MR images based on a level set method using an artificial neural network (ANN). To adjust the threshold value for the edge indicator function in the level set method to each true positive (TP) and false positive (FP) region, we constructed the ANN. The ANN could provide the suitable threshold value for each candidate region in the proposed level set method so that TP regions can be segmented and FP regions can be removed. Our proposed method detected MS regions at a sensitivity of 82.1% with 0.204 FPs per slice and similarity index of MS candidate regions was 0.717 on average. (author)

A cross-species genetic analysis identifies candidate genes for mouse anxiety and human bipolar disorder

Directory of Open Access Journals (Sweden)

David G Ashbrook

2015-07-01

Full Text Available Bipolar disorder (BD is a significant neuropsychiatric disorder with a lifetime prevalence of ~1%. To identify genetic variants underlying BD genome-wide association studies (GWAS have been carried out. While many variants of small effect associated with BD have been identified few have yet been confirmed, partly because of the low power of GWAS due to multiple comparisons being made. Complementary mapping studies using murine models have identified genetic variants for behavioral traits linked to BD, often with high power, but these identified regions often contain too many genes for clear identification of candidate genes. In the current study we have aligned human BD GWAS results and mouse linkage studies to help define and evaluate candidate genes linked to BD, seeking to use the power of the mouse mapping with the precision of GWAS. We use quantitative trait mapping for open field test and elevated zero maze data in the largest mammalian model system, the BXD recombinant inbred mouse population, to identify genomic regions associated with these BD-like phenotypes. We then investigate these regions in whole genome data from the Psychiatric Genomics Consortium’s bipolar disorder GWAS to identify candidate genes associated with BD. Finally we establish the biological relevance and pathways of these genes in a comprehensive systems genetics analysis.We identify four genes associated with both mouse anxiety and human BD. While TNR is a novel candidate for BD, we can confirm previously suggested associations with CMYA5, MCTP1 and RXRG. A cross-species, systems genetics analysis shows that MCTP1, RXRG and TNR coexpress with genes linked to psychiatric disorders and identify the striatum as a potential site of action. CMYA5, MCTP1, RXRG and TNR are associated with mouse anxiety and human BD. We hypothesize that MCTP1, RXRG and TNR influence intercellular signaling in the striatum.

Mining biological databases for candidate disease genes

Science.gov (United States)

Braun, Terry A.; Scheetz, Todd; Webster, Gregg L.; Casavant, Thomas L.

2001-07-01

The publicly-funded effort to sequence the complete nucleotide sequence of the human genome, the Human Genome Project (HGP), has currently produced more than 93% of the 3 billion nucleotides of the human genome into a preliminary `draft' format. In addition, several valuable sources of information have been developed as direct and indirect results of the HGP. These include the sequencing of model organisms (rat, mouse, fly, and others), gene discovery projects (ESTs and full-length), and new technologies such as expression analysis and resources (micro-arrays or gene chips). These resources are invaluable for the researchers identifying the functional genes of the genome that transcribe and translate into the transcriptome and proteome, both of which potentially contain orders of magnitude more complexity than the genome itself. Preliminary analyses of this data identified approximately 30,000 - 40,000 human `genes.' However, the bulk of the effort still remains -- to identify the functional and structural elements contained within the transcriptome and proteome, and to associate function in the transcriptome and proteome to genes. A fortuitous consequence of the HGP is the existence of hundreds of databases containing biological information that may contain relevant data pertaining to the identification of disease-causing genes. The task of mining these databases for information on candidate genes is a commercial application of enormous potential. We are developing a system to acquire and mine data from specific databases to aid our efforts to identify disease genes. A high speed cluster of Linux of workstations is used to analyze sequence and perform distributed sequence alignments as part of our data mining and processing. This system has been used to mine GeneMap99 sequences within specific genomic intervals to identify potential candidate disease genes associated with Bardet-Biedle Syndrome (BBS).

Pre-conceptual-schema-based patterns for deriving key performance indicators from strategic objectives

Directory of Open Access Journals (Sweden)

Carlos Mario Zapata Jaramillo

2017-05-01

Full Text Available Performance measurement is crucial for achieving business success. Moreover, such success is also related to the fulfillment of the organizational strategic objectives. Hence, an adequate determination of relevant performance indicators—or key performance indicators (KPIs—and their relationships to organizational objectives is needed. Even though several approaches for treating KPIs and objective-KPI relationships have been proposed, they exhibit some drawbacks associated with the lack of reusability and traceability. We attempt to fill this gap by proposing a set of patterns based on pre-conceptual schemas for supporting the systematic derivation of KPIs and their relationships to organizational objectives. In this way, the proposed patterns guarantee a reusable and traceable derivation process of a set of candidate KPIs from organizational strategic objectives. Lastly, we provide a lab study in order to illustrate the usefulness of this proposal.

Evaluating an australian emergency nurse practitioner candidate training program.

Science.gov (United States)

Plath, Sharyn J; Wright, Mary; Hocking, Julia

2017-11-01

Nurse Practitioners (NPs) receive core clinical training at master's level, with their employer providing the opportunity to upskill in clinical and procedural competencies. It is increasingly recognised that this generic education requires supplementary training for operating effectively within a specific clinical environment. In this paper we describe a pilot program designed to train Australian NP Candidates to work effectively within the Emergency Department Fast Track model of care. The training program consisted of a 12-month period: four hours in-house training per week over two semesters, running concurrently with the NP candidate's University semesters, and 3 months' clinical practice to consolidate. The training team defined milestones for Semesters one and two, and developed a case review form to assess application of the candidate's knowledge in new clinical situations, as well as check for gaps in understanding. A clinical skills guide was developed for the candidate to work toward, and a comprehensive assessment was carried out at two time points in the training program. Feedback was obtained from the mentors and the candidate at the end point of the training program, and has been used to refine the program for 2017. This in-house training program provided specialised, evidence-based training for the emergency department environment, resulting in development of the nurse practitioner candidate as a high functioning team member. Copyright © 2017 College of Emergency Nursing Australasia. All rights reserved.

Tokamak building-design considerations for a large tokamak device

International Nuclear Information System (INIS)

Barrett, R.J.; Thomson, S.L.

1981-01-01

Design and construction of a satisfactory tokamak building to support FED appears feasible. Further, a pressure vessel building does not appear necessary to meet the plant safety requirements. Some of the building functions will require safety class systems to assure reliable and safe operation. A rectangular tokamak building has been selected for FED preconceptual design which will be part of the confinement system relying on ventilation and other design features to reduce the consequences and probability of radioactivity release

New open cluster candidates discovered in the XSTPS-GAC survey

Science.gov (United States)

Guo, Jin-Cheng; Zhang, Hua-Wei; Zhang, Hui-Hua; Liu, Xiao-Wei; Yuan, Hai-Bo; Huang, Yang; Wang, Song; Chen, Li; Zhao, Hai-Bin; Liu, Ji-Feng; Chen, Bing-Qiu; Xiang, Mao-Sheng; Tian, Zhi-Jia; Huo, Zhi-Ying; Wang, Chun

2018-03-01

The Xuyi Schmidt Telescope Photometric Survey of the Galactic Anti-center (XSTPS-GAC) is a photometric sky survey that covers nearly 6000 deg2 towards the Galactic Anti-center (GAC) in the g, r, i bands. Half of its survey field is located on the Galactic Anti-center disk, which makes XSTPS-GAC highly suitable to search for new open clusters in the GAC region. In this paper, we report new open cluster candidates discovered in this survey, as well as properties of these open cluster candidates, such as age, distance and reddening, derived by isochrone fitting in the color-magnitude diagram (CMD). These open cluster candidates are stellar density peaks detected in the star density maps by applying the method from Koposov et al. Each candidate is inspected in terms of its true color image composed from three XSTPS-GAC band images. Then its CMD is checked, in order to identify whether the central region stars have a clear isochrone-like trend differing from background stars. The parameters derived from isochrone fitting for these candidates are mainly based on three band photometry of XSTPS-GAC. Moreover, when these new candidates are able to be seen clearly in 2MASS data, their parameters are also derived based on the 2MASS (J – H, J) CMD. There are a total of 320 known open clusters rediscovered and 24 new open cluster candidates discovered in this work. Furthermore, the parameters of these new candidates, as well as another 11 previously known open clusters, are properly determined for the first time.

Teacher Candidate Mental Health and Mental Health Literacy

Science.gov (United States)

Dods, Jennifer

2016-01-01

Providing teacher candidates with a strong foundation in mental health literacy during their teacher education program is crucial in ensuring novice teachers are prepared to support the mental health needs of their students. In addition to responding to students, teacher candidates are typically at an age when mental health disorders are common…

Metaphors of Social Studies Teacher Candidates on Democracy

Science.gov (United States)

Tural, Aysegül

2018-01-01

Democracy is a form of government in which principle of equality is based, human rights and freedoms are protected. In this research, it is aimed to reveal democracy perceptions of social science teacher candidates through metaphors. Towards this aim, 105 social science teacher candidates are consulted about their democracy opinions. Study is a…

MAT@USC Candidates and Latino English Language Learners

Science.gov (United States)

Lomeli, Cynthia Leticia

2012-01-01

The purpose of this study was to further understand the perceptions of MAT@USC teacher candidates and how their perceptions and previous experiences affect the educational experiences of Latino English language learners. Three questions were developed to guide this study: (1) What are the perceptions of MAT@USC candidates in selected courses…

Elementary School Teacher Candidates' Perceptions of Good Problems

Science.gov (United States)

Lee, Ji-Eun; Kim, Kyoung-Tae

2005-01-01

This study describes a classroom action research activity regarding a group of elementary school teacher candidates' perceptions of good mathematics problems. A questionnaire containing 20 problems was given, and the candidates were asked to rate the quality of each problem on a 5-point scale. The results revealed that the majority of the teacher…

Planet Candidate Validation in K2 Crowded Fields

Science.gov (United States)

Rampalli, Rayna; Vanderburg, Andrew; Latham, David; Quinn, Samuel

2018-01-01

In just three years, the K2 mission has yielded some remarkable outcomes with the discovery of over 100 confirmed planets and 500 reported planet candidates to be validated. One challenge with this mission is the search for planets located in star-crowded regions. Campaign 13 is one such example, located towards the galactic plane in the constellation of Taurus. We subject the potential planetary candidates to a validation process involving spectroscopy to derive certain stellar parameters. Seeing-limited on/off imaging follow-up is also utilized in order to rule out false positives due to nearby eclipsing binaries. Using Markov chain Monte Carlo analysis, the best-fit parameters for each candidate are generated. These will be suitable for finding a candidate’s false positive probability through methods including feeding such parameters into the Validation of Exoplanet Signals using a Probabilistic Algorithm (VESPA). These techniques and results serve as important tools for conducting candidate validation and follow-up observations for space-based missions such as the upcoming TESS mission since TESS’s large camera pixels resemble K2’s star-crowded fields.

Ultrasonographic diagnosis of fatty liver in preoperative evaluation of living liver donor candidates: Histologic correlation

International Nuclear Information System (INIS)

Kim, Seong Hyun; Lee, Won Jae; Lim, Hyo Keun; Kim, Soo Ah; Kim, Seung Hoon; Lee, Soon Jin; Lim, Jae Hoon

2003-01-01

To analyze the correlation between the ultrasonographic (US) grading system of fatty liver (FL) and histologic grading system in living liver donor candidates and to investigate the clinical significance of this qualitative US grading system in the selection of living donor candidates. For a recent 21-month period, ninety three living donor candidates who underwent both preoperative US and parenchymal biopsy of the liver were consecutively selected. FL was ultrasonographically graded using the well-known three-Point grading system (ie, mild, moderate and severe degrees) whereas histologic grade of FL was divided into minimal ( 60%) degrees depending upon the percentages of each of macrovesicular, microvesicular and total fat-containing hepatocytes. US grade and histologic grade of FL in each patient were retrospectively correlated according to the US and pathologic records in their databases. Statistical analysis was conducted with the chi-square test and linear by linear association. US findings included the normal liver, mild FL, and moderate FL in 63, 23 and 7 patients, respectively. Analyzed with the total fat content, 38 of 63 patients (60%) whose US finding was normal proved to have FL of various histologic grades. Meanwhile, US grade of FL correlated well with the histologic grade in 16 (53%) of 30 patients who showed mild or moderate FL on US, and in the remaining patients, US grade was more commonly underestimated compared to the histologic grade. All patients with moderate FL on US Proved to have either moderate or severe FL at histology. US grade statistically correlated well with the histologic grade classified by either the total or macrovesicular fat contents (p<.001) while a poor correlation was seen when histologic grade using the microvesicular fat content was used. The well-known qualitative US grading system of fatty liver seems to show a relatively good correlation with the histologic grade, but it has a tendency to underestimate compared to the

Reintroducing resurrected species: selecting DeExtinction candidates.

Science.gov (United States)

Seddon, Philip J; Moehrenschlager, Axel; Ewen, John

2014-03-01

Technological advances have raised the controversial prospect of resurrecting extinct species. Species DeExtinction should involve more than the production of biological orphans to be scrutinized in the laboratory or zoo. If DeExtinction is to realize its stated goals of deep ecological enrichment, then resurrected animals must be translocated (i.e., released within suitable habitat). Therefore, DeExtinction is a conservation translocation issue and the selection of potential DeExtinction candidates must consider the feasibility and risks associated with reintroduction. The International Union for the Conservation of Nature (IUCN) Guidelines on Reintroductions and Other Conservation Translocations provide a framework for DeExtinction candidate selection. We translate these Guidelines into ten questions to be addressed early on in the selection process to eliminate unsuitable reintroduction candidates. We apply these questions to the thylacine, Yangtze River Dolphin, and Xerces blue butterfly. Copyright © 2014 Elsevier Ltd. All rights reserved.

Caffeine Consumption Among Naval Aviation Candidates.

Science.gov (United States)

Sather, Thomas E; Williams, Ronald D; Delorey, Donald R; Woolsey, Conrad L

2017-04-01

Education frequently dictates students need to study for prolonged periods of time to adequately prepare for examinations. This is especially true with aviation preflight indoctrination (API) candidates who have to assimilate large volumes of information in a limited amount of time during API training. The purpose of this study was to assess caffeine consumption patterns (frequency, type, and volume) among naval aviation candidates attending API to determine the most frequently consumed caffeinated beverage and to examine if the consumption of a nonenergy drink caffeinated beverage was related to energy drink consumption. Data were collected by means of an anonymous 44-item survey administered and completed by 302 students enrolled in API at Naval Air Station Pensacola, FL. Results indicated the most frequently consumed caffeinated beverage consumed by API students was coffee (86.4%), with daily coffee consumption being approximately 28% and the most frequent pattern of consumption being 2 cups per day (85%). The least frequently consumed caffeinated beverages reported were energy drinks (52%) and energy shots (29.1%). The present study also found that the consumption patterns (weekly and daily) of caffeinated beverages (coffee and cola) were positively correlated to energy drink consumption patterns. Naval aviation candidates' consumption of caffeinated beverages is comparable to other college and high school cohorts. This study found that coffee and colas were the beverages of choice, with energy drinks and energy shots being the least frequently reported caffeinated beverages used. Additionally, a relationship between the consumption of caffeinated beverages and energy drinks was identified.Sather TE, Williams RD, Delorey DR, Woolsey CL. Caffeine consumption among naval aviation candidates. Aerosp Med Hum Perform. 2017; 88(4):399-405.

Screening candidate systems engineers: a research design

CSIR Research Space (South Africa)

Goncalves, DP

2009-07-01

Full Text Available engineering screening methodology that could be used to screen potential systems engineers. According to their design, this can be achieved by defining a system engineering profile according to specific psychological attributes, and using this profile...

Web tools for the prioritization of candidate disease genes.

NARCIS (Netherlands)

Oti, M.O.; Ballouz, S.; Wouters, M.A.

2011-01-01

Despite increasing sequencing capacity, genetic disease investigation still frequently results in the identification of loci containing multiple candidate disease genes that need to be tested for involvement in the disease. This process can be expedited by prioritizing the candidates prior to

Disease candidate gene identification and prioritization using protein interaction networks

Directory of Open Access Journals (Sweden)

Aronow Bruce J

2009-02-01

Full Text Available Abstract Background Although most of the current disease candidate gene identification and prioritization methods depend on functional annotations, the coverage of the gene functional annotations is a limiting factor. In the current study, we describe a candidate gene prioritization method that is entirely based on protein-protein interaction network (PPIN analyses. Results For the first time, extended versions of the PageRank and HITS algorithms, and the K-Step Markov method are applied to prioritize disease candidate genes in a training-test schema. Using a list of known disease-related genes from our earlier study as a training set ("seeds", and the rest of the known genes as a test list, we perform large-scale cross validation to rank the candidate genes and also evaluate and compare the performance of our approach. Under appropriate settings – for example, a back probability of 0.3 for PageRank with Priors and HITS with Priors, and step size 6 for K-Step Markov method – the three methods achieved a comparable AUC value, suggesting a similar performance. Conclusion Even though network-based methods are generally not as effective as integrated functional annotation-based methods for disease candidate gene prioritization, in a one-to-one comparison, PPIN-based candidate gene prioritization performs better than all other gene features or annotations. Additionally, we demonstrate that methods used for studying both social and Web networks can be successfully used for disease candidate gene prioritization.

Screening candidate systems engineers: exploratory results

CSIR Research Space (South Africa)

Gonçalves, D

2010-09-01

Full Text Available systems engineers for further development. Data were collected on personality, cognition, values and competence on 21 SE competencies using four computerised assessments. We report on the cognitive style distribution of the participating engineers...

Vote Choice, Ideology, and Social Dominance Orientation Influence Preferences for Lower Pitched Voices in Political Candidates

DEFF Research Database (Denmark)

Laustsen, Lasse; Petersen, Michael Bang; A. Klofstad, Casey

2015-01-01

Humans are equipped with a psychological system of followership that evolved to regulate choices of leaders based partly on would-be leaders’ physiological features. One such feature is voice pitch, which is determined by the physiology of the throat. Recent studies find that political candidates...... these findings by demonstrating that conservatives and Republicans tend to view the world as much more competitive and threatening than liberals and Democrats. We utilize two existing data sources to show that political candidates with lower-pitched voices are preferred more among conservative Republicans than...

Campaigning on the Internet: 2008 Presidential General Election Candidate Webpage

Directory of Open Access Journals (Sweden)

William L. Benoit

2016-12-01

Full Text Available The Internet is becoming an increasingly important component of political campaigns. This study employed content analysis to apply Functional Theory and Issue Ownership Theory to Obama’s and McCain’s presidential candidate webpages in the 2008 campaign. Acclaims (92% were more common than attacks (98%; defenses did not occur in this sample. Policy (82% was addressed more than character (18%. When discussing policy, these candidates addressed future plans most frequently, followed by general goals and then past deeds; on character, candidates discussed ideals, then personal qualities, and then leadership ability. This study shows that as candidates use the Internet to reach voters, their webpages conform to theoretical expectations.

High Temperature Gas-Cooled Reactors Lessons Learned Applicable to the Next Generation Nuclear Plant

Energy Technology Data Exchange (ETDEWEB)

J. M. Beck; L. F. Pincock

2011-04-01

The purpose of this report is to identify possible issues highlighted by these lessons learned that could apply to the NGNP in reducing technical risks commensurate with the current phase of design. Some of the lessons learned have been applied to the NGNP and documented in the Preconceptual Design Report. These are addressed in the background section of this document and include, for example, the decision to use TRISO fuel rather than BISO fuel used in the Peach Bottom reactor; the use of a reactor pressure vessel rather than prestressed concrete found in Fort St. Vrain; and the use of helium as a primary coolant rather than CO2. Other lessons learned, 68 in total, are documented in Sections 2 through 6 and will be applied, as appropriate, in advancing phases of design. The lessons learned are derived from both negative and positive outcomes from prior HTGR experiences. Lessons learned are grouped according to the plant, areas, systems, subsystems, and components defined in the NGNP Preconceptual Design Report, and subsequent NGNP project documents.

Construction of a trivalent candidate vaccine against Shigella species with DNA recombination

Institute of Scientific and Technical Information of China (English)

王恒樑; 冯尔玲; 林云; 廖翔; 金明; 黄留玉; 苏国富; 黄翠芬

2002-01-01

In this work asd gene of Shigella flexneri 2a strain T32 was replaced by Vibrio cholerae toxin B subunit (ctxB) gene with DNA recombination in vivo and in vitro. The resulting derivative of T32, designed as FWL01, could stably express CtxB, but its growth in LB medium depended on the presence of diaminopimelic acid (DAP). Then form I plasmid of Shigella sonnei strain S7 was labeled with strain T32 asd gene and mobilized into FWL01. Thus a trivalent candidate oral vaccine strain, designed as FSW01, was constructed. In this candidate strain, a balanced-lethal system was constituted between the host strain and the form I plasmid expressing S. sonnei O antigen. Therefore the candidate strain can express stably not only its own O antigen but also CtxB and O antigen of S. sonnei in the absence of any antibiotic. Experiments showed that FSW01 did not invade HeLa cells or cause keratoconjunctivitis in guinea pigs. However, rabbits immunized FSW01 can elicit significant immune responses. In mice and rhesus monkey models, vaccinated animals were protected against the challenges of wild S. flexneri 2a strain 2457T and S. sonnei strain S9.

t Leave Before You Understand': Supporting Masters Candidates in ...

African Journals Online (AJOL)

example, due to increased enrolments and the 'pile up' effect, South African academics are increasingly burdened with ... postgraduate level. This research study is part of a larger study on candidates' experiences of postgraduate business studies, with the aim of enhancing supervision practices for the benefit of candidates.

Teacher Candidate Technology Integration: For Student Learning or Instruction?

Science.gov (United States)

Clark, Cynthia; Zhang, Shaoan; Strudler, Neal

2015-01-01

Transfer of instructional technology knowledge for student-centered learning by teacher candidates is investigated in this study. Using the transfer of learning theoretical framework, a mixed methods research design was employed to investigate whether secondary teacher candidates were able to transfer the instructional technology knowledge for…

Evaluation of project based learning sufficiency of teacher candidates

Directory of Open Access Journals (Sweden)

Vasfi Tugun

2012-01-01

Full Text Available The aim of that research, it is the project based learning process suffuciency of teacher candidates who developedmultimedia by working in online and blended groups. Importance of research Being able to guide to studies that is going tobe done about assessment of multimedia projection for project based educational application to teachers and teachercandidates and It has been thought as an advisor source about being arranged new educational environment for the futureto teacher and teacher candidates for project based educational application and multimedia projection. Research is anexperimental study and has been shaped according to pre-test and last-test research model with the two groups. This groupsare online group and blended group. Discussion of research In the result of the study, in the process of project basedlearning, it is determined that the success level in multimedia development of teacher candidates who work in blendedlearning model is higher than the success level of teacher candidates who work in online learning model.

A Tendon Cell Specific RNAi Screen Reveals Novel Candidates Essential for Muscle Tendon Interaction.

Directory of Open Access Journals (Sweden)

Prabhat Tiwari

Full Text Available Tendons are fibrous connective tissue which connect muscles to the skeletal elements thus acting as passive transmitters of force during locomotion and provide appropriate body posture. Tendon-derived cues, albeit poorly understood, are necessary for proper muscle guidance and attachment during development. In the present study, we used dorsal longitudinal muscles of Drosophila and their tendon attachment sites to unravel the molecular nature of interactions between muscles and tendons. We performed a genetic screen using RNAi-mediated knockdown in tendon cells to find out molecular players involved in the formation and maintenance of myotendinous junction and found 21 candidates out of 2507 RNAi lines screened. Of these, 19 were novel molecules in context of myotendinous system. Integrin-βPS and Talin, picked as candidates in this screen, are known to play important role in the cell-cell interaction and myotendinous junction formation validating our screen. We have found candidates with enzymatic function, transcription activity, cell adhesion, protein folding and intracellular transport function. Tango1, an ER exit protein involved in collagen secretion was identified as a candidate molecule involved in the formation of myotendinous junction. Tango1 knockdown was found to affect development of muscle attachment sites and formation of myotendinous junction. Tango1 was also found to be involved in secretion of Viking (Collagen type IV and BM-40 from hemocytes and fat cells.

Virus-like particles as nanovaccine candidates

International Nuclear Information System (INIS)

Guillen, G; Aguilar, J C; Dueñas, S; Hermida, L; Iglesias, E; Penton, E; Lobaina, Y; Lopez, M; Mussachio, A; Falcon, V; Alvarez, L; Martinez, G; Gil, L; Valdes, I; Izquierdo, A; Lazo, L; Marcos, E; Guzman, G; Muzio, V; Herrera, L

2013-01-01

The existing vaccines are mainly limited to the microorganisms we are able to culture and produce and/or to those whose killing is mediated by humoral response (antibody mediated). It has been more difficult to develop vaccines capable of inducing a functional cellular response needed to prevent or cure chronic diseases. New strategies should be taken into account in the improvement of cell-based immune responses in order to prevent and control the infections and eventually clear the virus. Preclinical and clinical results with vaccine candidates developed as a vaccine platform based on virus-like particles (VLPs) evidenced their ability to stimulate mucosal as well as systemic immunity. Particles based on envelope, membrane or nucleocapsid microbial proteins induce a strong immune response after nasal or parenteral administration in mice, non-human primates and humans. In addition, the immune response obtained was modulated in a Th1 sense. The VLPs were also able to immunoenhance the humoral and cellular immune responses against several viral pathogens. Studies in animals and humans with nasal and systemic formulations evidenced that it is possible to induce functional immune response against HBV, HCV, HIV and dengue virus. (paper)

Technical description of candidate fluorescence compounds and radioisotopes for a nuclear smuggling deterrence tag (IL500E)

International Nuclear Information System (INIS)

Hartenstein, S.D.; Aryaeinejad, R.

1996-03-01

This report summarizes the efforts completed in identifying candidate fluorescence compounds and radioisotopes for a developing tagging system. The tagging system is being developed as a deterrent to nuclear smuggling, by providing a means of: (1) tracing materials and pilferers to the facility of origin for any recovered special nuclear materials; (2) inventory control of long-term stored items containing special nuclear materials; and (3) tracking materials transferred between facilities. The tagging system uses four types of tagging materials to cover a range of applications intended to prevent the pilfering of special nuclear materials. One material, fluorescent compounds which are invisible without ultraviolet or near-infrared detection systems, is marked on controlled items with a tracking pattern that corresponds to a specified item in a specified location in the data control system. The tagging system uses an invisible, fluorescent dusting powder to mark equipment and personnel who inappropriately handle the tagged material. The tagging system also uses unique combinations of radionuclides to identify the facility of origin for any special nuclear material. Currently, 18 long-lived radioisotopes, 38 short-live radioisotopes and 10 fluorescent compounds have been selected as candidate materials for the tagging system

Technical description of candidate fluorescence compounds and radioisotopes for a nuclear smuggling deterrence tag (IL500E)

Energy Technology Data Exchange (ETDEWEB)

Hartenstein, S.D.; Aryaeinejad, R.

1996-03-01

This report summarizes the efforts completed in identifying candidate fluorescence compounds and radioisotopes for a developing tagging system. The tagging system is being developed as a deterrent to nuclear smuggling, by providing a means of: (1) tracing materials and pilferers to the facility of origin for any recovered special nuclear materials; (2) inventory control of long-term stored items containing special nuclear materials; and (3) tracking materials transferred between facilities. The tagging system uses four types of tagging materials to cover a range of applications intended to prevent the pilfering of special nuclear materials. One material, fluorescent compounds which are invisible without ultraviolet or near-infrared detection systems, is marked on controlled items with a tracking pattern that corresponds to a specified item in a specified location in the data control system. The tagging system uses an invisible, fluorescent dusting powder to mark equipment and personnel who inappropriately handle the tagged material. The tagging system also uses unique combinations of radionuclides to identify the facility of origin for any special nuclear material. Currently, 18 long-lived radioisotopes, 38 short-live radioisotopes and 10 fluorescent compounds have been selected as candidate materials for the tagging system.

High integrity software for nuclear power plants: Candidate guidelines, technical basis and research needs. Executive summary: Volume 1

International Nuclear Information System (INIS)

Seth, S.; Bail, W.; Cleaves, D.; Cohen, H.; Hybertson, D.; Schaefer, C.; Stark, G.; Ta, A.; Ulery, B.

1995-06-01

The work documented in this report was performed in support of the US Nuclear Regulatory Commission to examine the technical basis for candidate guidelines that could be considered in reviewing and evaluating high integrity computer software used in the safety systems of nuclear power plants. The framework for the work consisted of the following software development and assurance activities: requirements specification; design; coding; verification and validation, including static analysis and dynamic testing; safety analysis; operation and maintenance; configuration management; quality assurance; and planning and management. Each activity (framework element) was subdivided into technical areas (framework subelements). The report describes the development of approximately 200 candidate guidelines that span the entire range of software life-cycle activities; the assessment of the technical basis for those candidate guidelines; and the identification, categorization and prioritization of research needs for improving the technical basis. The report has two volumes: Volume 1, Executive Summary, includes an overview of the framework and of each framework element, the complete set of candidate guidelines, the results of the assessment of the technical basis for each candidate guideline, and a discussion of research needs that support the regulatory function; Volume 2 is the main report

Campaigning on behalf of the party? Party constraints on candidate campaign personalisation

DEFF Research Database (Denmark)

Bøggild, Troels; Pedersen, Helene Helboe

2017-01-01

This article analyses what makes political candidates run a party-focused or personalised election campaign. Prior work shows that candidates face incentives from voters and the media to personalise their campaign rhetoric and promises at the expense of party policy. This has raised concerns about...... that party control over the candidate nomination process and campaign financing constrains most political candidates in following electoral incentives for campaign personalisation. Using candidate survey data from the 2009 EP election campaign in 27 countries, we show how candidates from parties in which...... party officials exerted greater control over the nomination process and campaign finances were less likely to engage in personalised campaigning at the expense of the party programme. The findings imply that most parties, as central gatekeepers and resource suppliers, hold important control mechanisms...

Development of the Korean Reference Vertical Disposal System Concept for Spent Fuels

International Nuclear Information System (INIS)

Lee, J.Y.; Cho, D.K.; Kim, S.G.; Choi, H.J.; Choi, J.W.; Hahn, P.S.

2006-01-01

The development of a deep geologic disposal system for the spent fuel from nuclear power plants has been carried out since this program was launched at 1997 in Korea. In ' this paper, a pre-conceptual design of the Korean Reference HLW Vertical disposal System (KRS-V1) is presented. Though no site for the underground repository has yet been specified in Korea, a generic site with granitic rock is considered for reference HLW repository design. Depth of the repository is assumed to be 500 meters. The repository consists of the disposal area, technical rooms with four shafts to connect them to the ground level in the controlled area and technical rooms with an access tunnel and three shafts to connect them to the ground level in the uncontrolled area. Disposal area consists of disposal tunnels, panel tunnels and a central tunnel. The repository will be excavated, operated and backfilled in several phases including an Underground Research Laboratory (URL) phase. The result of this preliminary conceptual design will be used for an evaluation of the feasibility, analyses of the long term safety, information for public communication and a cost estimation etc. (authors)

Preliminary safety equipment list for Tank 241-C-106 Manipulator Retrieval System, Project W-340

International Nuclear Information System (INIS)

Guthrie, R.L.

1994-01-01

This document identifies the anticipated safety classification of the estimated major subsystems, based on the projected major functions, that will be used as guidance for the development of the conceptual design of the Manipulator Retrieval System for Tank 241-C-106. This document is intended to be updated as the design of the Manipulator Retrieval System evolves through the conceptual and definitive design phases. The Manipulator Retrieval System is to be capable of removing the hardened sludge heel at the bottom of single shell Tank 241-C-106 and to perform an overall clean out of the tank that leaves a maximum of 360 ft 3 (TPA milestone M-45-00). The thickness of the heel prior to initiation of waste retrieval with the Manipulator Retrieval System is estimated to be 1- to 2-ft. The Manipulator Retrieval System is currently in the pre-conceptual phase with no definitive systems or subsystems. The anticipated retrieval functions for the Manipulator Retrieval System is based on Table 6-2 of WHC-SD-W340-ES-001, Rev. 1. Projected equipment to accomplish these functions were based on the following systems and equipment: Rotary Mode Core Sampling Equipment (WHC-SD-WM-SEL-032); Light Duty Utility Arm System Equipment (WHC-SD-WM-SEL-034); Single Shell Tanks Equipment (WHC-SD-WM-SEL-020)

LOD score exclusion analyses for candidate QTLs using random population samples.

Science.gov (United States)

Deng, Hong-Wen

2003-11-01

While extensive analyses have been conducted to test for, no formal analyses have been conducted to test against, the importance of candidate genes as putative QTLs using random population samples. Previously, we developed an LOD score exclusion mapping approach for candidate genes for complex diseases. Here, we extend this LOD score approach for exclusion analyses of candidate genes for quantitative traits. Under this approach, specific genetic effects (as reflected by heritability) and inheritance models at candidate QTLs can be analyzed and if an LOD score is < or = -2.0, the locus can be excluded from having a heritability larger than that specified. Simulations show that this approach has high power to exclude a candidate gene from having moderate genetic effects if it is not a QTL and is robust to population admixture. Our exclusion analysis complements association analysis for candidate genes as putative QTLs in random population samples. The approach is applied to test the importance of Vitamin D receptor (VDR) gene as a potential QTL underlying the variation of bone mass, an important determinant of osteoporosis.

Planetary Candidates Observed by Kepler, III: Analysis of the First 16 Months of Data

DEFF Research Database (Denmark)

Batalha, Natalie M.; Rowe, Jason F.; Bryson, Stephen T.

2012-01-01

candidates has grown from 17% to 20%, and the paucity of short-period giant planets in multiple systems is still evident. The progression toward smaller planets at longer orbital periods with each new catalog release suggests that Earth-size planets in the Habitable Zone are forthcoming if, indeed...

Undergraduate Teacher Candidate Perceptions Integrating Technology in Classroom Instruction

Science.gov (United States)

Anderson, Charlise Askew

2016-01-01

The purpose of this study was to analyze undergraduate teacher candidates' perceptions on integrating technology in the classroom. The study was embedded in the "Technology Pedagogical Content Knowledge" theoretical model. A sample of 143 undergraduate teacher candidates participated in the study. They were asked to address items on a…

14 CFR 91.321 - Carriage of candidates in elections.

Science.gov (United States)

2010-01-01

... carrier or commercial operator; (2) You carry the candidate, agent, or person traveling on behalf of a... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Carriage of candidates in elections. 91.321 Section 91.321 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION...

Social Studies Teacher Candidates' Views on Historical Thinking Skills

Science.gov (United States)

Ozmen, Cengiz

2015-01-01

Current study aimed to present Social Studies teacher candidates' views on historical thinking skills. Study was conducted using qualitative design and working group was composed of a total of 121 teacher candidates (62 females and 59 males) attending Social Studies Teaching Department of Karadeniz Technical University and Adiyaman University…

Development of geological disposal system; localization of element cost data and cost evaluation on the HLW repository

Energy Technology Data Exchange (ETDEWEB)

Lee, Byung Sik; Kim, Kil Jung; Yang, Young Jin; Kim, Sung Chun [KOPEC, Taejeon (Korea)

2002-03-01

To estimate Total Life Cycle Cost (TSLCC) for Korea HLW Repository through localization of element cost data, we review and re-organize each basic element cost data for reference repository system, localize various element cost and finally estimate TSLCC considering economic parameters. As results of the study, TSLCC is estimated as 17,167,689 million won, which includes costs for site preparation, surface facilities, underground facilities and management/integration. Since HLW repository Project is an early stage of pre-conceptual design at present, the information of design and project information are not enough to perform cost estimate and cost localization for the Project. However, project cost structure is re-organized based on the local condition and Total System Life Cycle Cost is estimated using the previous cost data gathered from construction experience of the local nuclear power plant. Project results can be used as basic reference data to assume total construction cost for the local HLW repository and should be revised to more reliable cost data with incorporating detail project design information into the cost estimate in a future. 20 refs. (Author)

COMPARATIVE EFFECTIVENESS OF DIFFERENT METHODS OF CANDIDAL DYSBACTERIOSIS THERAPY

Directory of Open Access Journals (Sweden)

S.V. Nikolaeva

2009-01-01

Full Text Available The study of effectiveness of different methods of microbiological disorders correction in children after 3 years old with candidal dysbacteriosis are presented in this article. The study compared probiotical sour milk-made stuff («Actimel» and sour milk-made stuff, not fortified with probiotical cultures («Rastishka» and traditional kefir. It was shown that an inclusion of probiotical sour milkmade stuff in diet of children with candidal dysbacteriosis results in normalization of lacto- and bifidobacteria level and decreasing of Candida level.Key words: children, candidal dysbacteriosis, probiotics.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2009;8(6:31-35

Toward Detection of Exoplanetary Rings via Transit Photometry: Methodology and a Possible Candidate

Energy Technology Data Exchange (ETDEWEB)

Aizawa, Masataka; Masuda, Kento; Suto, Yasushi [Department of Physics, The University of Tokyo, Tokyo, 113-0033 (Japan); Uehara, Sho [Department of Physics, Tokyo Metropolitan University, Tokyo 192-4397 (Japan); Kawahara, Hajime, E-mail: aizawa@utap.phys.s.u-tokyo.ac.jp [Department of Earth and Planetary Science, The University of Tokyo, Tokyo 113-0033 (Japan)

2017-04-01

The detection of a planetary ring of exoplanets remains one of the most attractive, but challenging, goals in the field of exoplanetary science. We present a methodology that implements a systematic search for exoplanetary rings via transit photometry of long-period planets. This methodology relies on a precise integration scheme that we develop to compute a transit light curve of a ringed planet. We apply the methodology to 89 long-period planet candidates from the Kepler data so as to estimate, and/or set upper limits on, the parameters of possible rings. While the majority of our samples do not have sufficient signal-to-noise ratios (S/Ns) to place meaningful constraints on ring parameters, we find that six systems with higher S/Ns are inconsistent with the presence of a ring larger than 1.5 times the planetary radius, assuming a grazing orbit and a tilted ring. Furthermore, we identify five preliminary candidate systems whose light curves exhibit ring-like features. After removing four false positives due to the contamination from nearby stars, we identify KIC 10403228 as a reasonable candidate for a ringed planet. A systematic parameter fit of its light curve with a ringed planet model indicates two possible solutions corresponding to a Saturn-like planet with a tilted ring. There also remain two other possible scenarios accounting for the data; a circumstellar disk and a hierarchical triple. Due to large uncertain factors, we cannot choose one specific model among the three.

THE CANDIDATE CLUSTER AND PROTOCLUSTER CATALOG (CCPC). II. SPECTROSCOPICALLY IDENTIFIED STRUCTURES SPANNING 2 <  z  < 6.6

Energy Technology Data Exchange (ETDEWEB)

Franck, J. R.; McGaugh, S. S. [Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106 (United States)

2016-12-10

The Candidate Cluster and Protocluster Catalog (CCPC) is a list of objects at redshifts z  > 2 composed of galaxies with spectroscopically confirmed redshifts that are coincident on the sky and in redshift. These protoclusters are identified by searching for groups in volumes corresponding to the expected size of the most massive protoclusters at these redshifts. In CCPC1 we identified 43 candidate protoclusters among 14,000 galaxies between 2.74 <  z  < 3.71. Here we expand our search to more than 40,000 galaxies with spectroscopic redshifts z  > 2.00, resulting in an additional 173 candidate structures. The most significant of these are 36 protoclusters with overdensities δ {sub gal} > 7. We also identify three large proto-supercluster candidates containing multiple protoclusters at z  = 2.3, 3.5 and z  = 6.56. Eight candidates with N  ≥ 10 galaxies are found at redshifts z  > 4.0. The last system in the catalog is the most distant spectroscopic protocluster candidate known to date at z  = 6.56.

The attitudes of classroom teacher candidates towards physical education lesson

Directory of Open Access Journals (Sweden)

Gönül Tekkurşun Demir

2017-12-01

Full Text Available Aim: It is aimed to determine the attitudes of the 2nd, 3rd, and 4th grade classroom teacher candidates towards the physical education lesson according to various variables. Material and Methods: For the current study, the screening method, one of the quantitative research models, was used. The research consists of 2nd, 3rd, and 4th grade, totally164 university students, 106 (%64,6 females, 58 (%35,4 males, attending Uşak University, Classroom Teaching Program in 2016-2017 academic year. The first-grade students were not included in this research, because the physical education and play teaching lessons are given to classroom student candidates in the second-grade at Uşak University, Classroom Teaching Program. “Personal information form" and “Physical Education Lesson Attitude Scale for Classroom Teacher Candidates" were used as data collection tools. Before analysis, the data were evaluated using the values of Skewness and Skewness (normal distribution of the data and Levene (equality of variance tests. In the analysis of the data; frequency, arithmetic mean, standard deviation; t-test, ANOVA and Pearson Correlation test were used. Results: When examined the total score of the teacher candidates obtained from Physical Education Lesson Attitude Scale for Classroom Teacher Candidates and age variable by the Pearson Moment Correlation analysis, it was found that there was a statistically significant negative relationship between the received scores at low level. It was determined that the attitudes of the classroom teacher candidates towards the physical education lessons did not show any significant difference according to the gender variable, but there was a significant difference when examined their class levels. While no significant difference was found in the attitudes of the classroom teacher candidates, who played and did not play sports in their past life, towards physical education lessons, no significant difference was found

THE LICK-CARNEGIE SURVEY: FOUR NEW EXOPLANET CANDIDATES

International Nuclear Information System (INIS)

Meschiari, Stefano; Laughlin, Gregory; Vogt, Steven S.; Rivera, Eugenio J.; Butler, R. Paul; Haghighipour, Nader; Jalowiczor, Peter

2011-01-01

We present new precise HIRES radial velocity (RV) data sets of five nearby stars obtained at Keck Observatory. HD 31253, HD 218566, HD 177830, HD 99492, and HD 74156 are host stars of spectral classes F through K and show RV variations consistent with new or additional planetary companions in Keplerian motion. The orbital parameters of the candidate planets in the five planetary systems span minimum masses of M sin i = 27.43 M + to 8.28 M J , periods of 17.05-4696.95 days and eccentricities ranging from circular to extremely eccentric (e ∼ 0.63). The fifth star, HD 74156, was known to have both a 52 day and a 2500 day planet, and was claimed to also harbor a third planet at 336 days, in apparent support of the 'Packed Planetary System' hypothesis. Our greatly expanded data set for HD 74156 provides strong confirmation of both the 52 day and 2500 day planets, but strongly contradicts the existence of a 336 day planet, and offers no significant evidence for any other planets in the system.

Kepler Confirmation of Multi-Planet Systems

Science.gov (United States)

Cochran, W. D.

2011-10-01

The NASA Kepler spacecraft has detected 170 candidate multi-planet systems in the first two quarters of data released in February 2011 by Borucki et al. (2011). These systems comprise 115 double candidate systems, 45 triple candidate sys- tems, and 10 systems with 4 or more candidate planets. The architecture and dynamics of these systems were discussed by Lissauer et al. (2011), and a comparison of candidates in single- and multi-planet systems was presented by Latham et al. (2011). Proceeding from "planetary candidate" systems to confirmed and validated multi-planet systems is a difficult process, as most of these systems orbit stars too faint to obtain extremely precise (1ms-1) radial velocity confimation. Here, we discuss in detail the use of transit timing vari- ations (cf. e.g. Holman et al., 2010) to confirm planets near a mean motion resonance. We also discuss extensions to the BLENDER validation (Torres et al., 2004, 2011; Fressin et al., 2011) to validate planets in multi-planet systems. Kepler was competitively selected as the tenth Discovery mission. Funding for the Kepler Mis- sion is provided by NASA's Science Mission Direc- torate. We are deeply grateful for the very hard work of the entire Kepler team.

Oral candidal species among smokers and non-smokers.

Science.gov (United States)

Rasool, S; Siar, C H; Ng, K P

2005-11-01

To determine the various oral Candidal species among healthy Malaysian adults. Case-control study. This study was collaborated between the Department of Medical Microbiology, Faculty of Medicine and Department of Oral Pathology, Oral Medicine and Periodontology, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia, between September 2002 till January 2004. One hundred adults (50 smokers and 50 non-smokers), aged between 40 and 70 years were studied. Swabs and carbohydrate assimilation (Saboraud Dextrose Agar, Corn Meal Agar, API 20C AUX System) were performed. Specimens were collected from dorsum of the tongue, buccal mucosa and commissures (right and left each). Colony forms were established by positive colony forming units, on SDA medium (24-48 hours). Germ tube test for (true/pseudohyphae) growth was done on Corn Meal Agar Medium. Candida biotypes were evaluated by API 20C AUX system, which had a numerical 7 digit profile, added to evaluate a definite Candida species. Thirty-five percent of Malaysian adults harbored Candida intraorally. Candidal species identified among 100 subjects had C. albicans (27) 77%, C. glabrata (3) 8%, C. famata, C. tropicalis, C. krusei, C. lusitaniae and C. guilliermondii (1) 3% each. Thirty-three positive cases comprised of 35 species i.e. two cases had two species each. Fifty seven percent of these were smokers and 43% non-smokers. These included 40% Chinese, 36% Malays and 24% Indians. Species were, however, not specified according to intra-oral sites i.e. buccal, commissural mucosa and dorsum of tongue. On this series C. albicans is the most common species found in the oral cavity of Malaysian adults. It is equally frequent in smokers and non-smokers, but showed a predilection for the ethnic Chinese group.

University Offer Rates for Candidates from Different Ethnic Categories

Science.gov (United States)

Noden, Philip; Shiner, Michael; Modood, Tariq

2014-01-01

Previous research suggested that candidates from some black and minority ethnic groups were less likely to receive an offer of a place from an "old" university. These findings were disputed in a re-analysis carried out for HEFCE which found that only Pakistani candidates were significantly less likely to receive offers (from both…

Assessing Student Teaching Experiences: Teacher Candidates' Perceptions of Preparedness

Science.gov (United States)

Lee, Joohi; Tice, Kathleen; Collins, Denise; Brown, Amber; Smith, Cleta; Fox, Jill

2012-01-01

The purpose of this study is to investigate the effectiveness of student teaching experiences by measuring teacher candidates' perceptions of their preparedness. The participants were 130 teacher candidates who had completed their student teaching as part of a program preparing them to teach children in pre-K through grade 4. Teacher candidates…

Energy Beverage Consumption Among Naval Aviation Candidates.

Science.gov (United States)

Sather, Thomas E; Delorey, Donald R

2016-06-01

Since the debut of energy beverages, the consumption of energy beverages has been immensely popular with young adults. Research regarding energy beverage consumption has included college students, European Union residents, and U.S. Army military personnel. However, energy beverage consumption among naval aviation candidates in the United States has yet to be examined. The purpose of this study was to assess energy beverage consumption patterns (frequency and volume) among naval aviation candidates, including attitudes and perceptions regarding the benefits and safety of energy beverage consumption. A 44-item survey was used to assess energy beverage consumption patterns of 302 students enrolled in the Aviation Preflight Indoctrination Course at Naval Air Station Pensacola, FL. Results indicated that 79% of participants (N = 239) reported consuming energy beverages within the last year. However, of those who reported consuming energy beverages within the last year, only 36% (N = 85) reported consuming energy beverages within the last 30 d. Additionally, 51% (N = 153) of participants reported no regular energy beverages consumption. The majority of participants consumed energy beverages for mental alertness (67%), mental endurance (37%), and physical endurance (12%). The most reported side effects among participants included increased mental alertness (67%), increased heart rate (53%), and restlessness (41%). Naval aviation candidates appear to use energy drinks as frequently as a college student population, but less frequently than expected for an active duty military population. The findings of this study indicate that naval aviation candidates rarely use energy beverages (less than once per month), but when consumed, they use it for fatigue management.

A Research on the Burnout and the Teaching Profession Attitudes of Teacher Candidates

Science.gov (United States)

Kadi, Aysegül; Beytekin, Osman Ferda; Arslan, Hasan

2015-01-01

Purpose of this study is to examine burnout and teaching profession attitudes of teacher candidates. Research was conducted with 287 teacher candidates. By the findings; burnout and teaching profession attitudes of teacher candidates don't differ according to their gender. Burnout of teacher candidates differs according to their graduation status…

Proteomic analysis of cerebrospinal fluid from children with central nervous system tumors identifies candidate proteins relating to tumor metastatic spread.

Science.gov (United States)

Spreafico, Filippo; Bongarzone, Italia; Pizzamiglio, Sara; Magni, Ruben; Taverna, Elena; De Bortoli, Maida; Ciniselli, Chiara M; Barzanò, Elena; Biassoni, Veronica; Luchini, Alessandra; Liotta, Lance A; Zhou, Weidong; Signore, Michele; Verderio, Paolo; Massimino, Maura

2017-07-11

Central nervous system (CNS) tumors are the most common solid tumors in childhood. Since the sensitivity of combined cerebrospinal fluid (CSF) cytology and radiological neuroimaging in detecting meningeal metastases remains relatively low, we sought to characterize the CSF proteome of patients with CSF tumors to identify biomarkers predictive of metastatic spread. CSF samples from 27 children with brain tumors and 13 controls (extra-CNS non-Hodgkin lymphoma) were processed using core-shell hydrogel nanoparticles, and analyzed with reverse-phase liquid chromatography/electrospray tandem mass spectrometry (LC-MS/MS). Candidate proteins were identified with Fisher's exact test and/or a univariate logistic regression model. Reverse phase protein array (RPPA), Western blot (WB), and ELISA were used in the training set and in an independent set of CFS samples (60 cases, 14 controls) to validate our discovery findings. Among the 558 non-redundant proteins identified by LC-MS/MS, 147 were missing from the CSF database at http://www.biosino.org. Fourteen of the 26 final top-candidate proteins were chosen for validation with WB, RPPA and ELISA methods. Six proteins (type 1 collagen, insulin-like growth factor binding protein 4, procollagen C-endopeptidase enhancer 1, glial cell-line derived neurotrophic factor receptor α2, inter-alpha-trypsin inhibitor heavy chain 4, neural proliferation and differentiation control protein-1) revealed the ability to discriminate metastatic cases from controls. Combining a unique dataset of CSFs from pediatric CNS tumors with a novel enabling nanotechnology led us to identify CSF proteins potentially related to metastatic status.

Sealing a nuclear waste repository in Columbia river basalt: preliminary results

International Nuclear Information System (INIS)

Hodges, F.N.

1980-01-01

The long containment time required of repositories for nuclear waste (10 4 to 10 6 years) requires that materials used for repository seals be stable in the geologic environment of the repository and of proven longevity. A list of candidate materials for sealing a repository in Columbia River Basalts has been prepared and refined through laboratory testing. The most feasible techniques for emplacing preferred plug materials have been identified and the resultant plugs have been evaluated on the basis of design functions. Preconceptual designs for tunnel, shaft, and borehole seals consist of multiple zone plugs with each zone fulfilling one or more design functions. Zones of disturbed rock around tunnels and shafts, resulting from excavation and subsequent stress release, are zones of higher permeability and of possible fluid migration. In preliminary designs the disturbed zones are blocked by cut-off collars filled with low permeability materials

Relationship of candidate communication and organization skills to oral certification examination scores.

Science.gov (United States)

Houston, James E; Smith, Everett V

2008-12-01

This study investigated the relationship between candidate's proficiency in communication/organization and ability measures derived from judges' oral examination ratings on a medical specialty certification examination. Judges who rated candidates on the oral examination also provided a separate rating for candidates' communication/organization skills. ANOVA was used to examine differences among levels of communication/organizational skills with respect to candidates' ability measures on the oral examination. There was a statistically significant increase in oral examination measures for candidates with higher levels of communication/organization skills. This supports the hypothesis that candidates who were more proficient in organizing and presenting their responses were more likely to have better performance on the oral examination. Given communication and oral examination ratings were provided by the same judges, future research should investigate whether these preliminary findings generalize to situations in which communication ratings are obtained from independent ratings during and outside the oral examination.

Pulmonary rehabilitation in lung transplant candidates.

Science.gov (United States)

Li, Melinda; Mathur, Sunita; Chowdhury, Noori A; Helm, Denise; Singer, Lianne G

2013-06-01

While awaiting lung transplantation, candidates may participate in pulmonary rehabilitation to improve their fitness for surgery. However, pulmonary rehabilitation outcomes have not been systematically evaluated in lung transplant candidates. This investigation was a retrospective cohort study of 345 pre-transplant pulmonary rehabilitation participants who received a lung transplant between January 2004 and June 2009 and had available pre-transplant exercise data. Data extracted included: 6-minute walk tests at standard intervals; exercise training details; health-related quality-of-life (HRQL) measures; and early post-transplant outcomes. Paired t-tests were used to examine changes in the 6MW distance (6MWD), exercise training volume and HRQL during the pre-transplant period. We evaluated the association between pre-transplant 6MWD and transplant hospitalization outcomes. The final 6MWD prior to transplantation was only 15 m less than the listing 6MWD (n = 200; p = 0.002). Exercise training volumes increased slightly from the start of the pulmonary rehabilitation program until transplant: treadmill, increase 0.69 ml/kg/min (n = 238; p volumes are well preserved among lung transplant candidates participating in pulmonary rehabilitation, even in the setting of severe, progressive lung disease. Participants with greater exercise capacity prior to transplantation have more favorable early post-transplant outcomes. Copyright © 2013 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.

Candidate container materials for Yucca Mountain waste package designs

International Nuclear Information System (INIS)

McCright, R.D.; Halsey, W.G.; Gdowski, G.E.; Clarke, W.L.

1991-09-01

Materials considered as candidates for fabricating nuclear waste containers are reviewed in the context of the Conceptual Design phase of a potential repository located at Yucca Mountain. A selection criteria has been written for evaluation of candidate materials for the next phase -- Advanced Conceptual Design. The selection criteria is based on the conceptual design of a thin-walled container fabricated from a single metal or alloy; the criteria consider the performance requirements on the container and the service environment in which the containers will be emplaced. A long list of candidate materials is evaluated against the criteria, and a short list of materials is proposed for advanced characterization in the next design phase

Pharmacology of biosimilar candidate drugs in rheumatology: a literature review.

Science.gov (United States)

Araújo, F; Cordeiro, I; Teixeira, F; Gonçalves, J; Fonseca, J E

2014-01-01

To review current evidence concerning pharmacology of biosimilar candidates to be used in rheumatology. A PubMed search up to August 2013 was performed using relevant search terms to include all studies assessing pharmacological properties of biosimilar candidates to be used in rheumatology. Data on study characteristics, type of intervention, pharmacokinetics (PK), pharmacodynamics (PD) and bioequivalence ratios was extracted. Of 280 articles screened, 5 fulfilled our inclusion criteria. Two trials, PLANETAS and PLANETRA, compared CT-P13 and infliximab in patients with active ankylosing spondylitis and rheumatoid arthritis, respectively. PK bioequivalence was demonstrated in the phase 1 PLANETAS trial by highly comparable area under the curve (AUC) and maximum drug concentrations (Cmax), whose geometric mean ratios fell between the accepted bioequivalence range of 80-125%. Equivalence in efficacy and safety was demonstrated in the phase 3 PLANETRA trial. Two phase 1 trials comparing etanercept biosimilar candidates TuNEX and HD203 in healthy volunteers showed a high degree of similarity in AUC and Cmax, with respective geometric mean ratios between PK bioequivalence range. The last included trial referred to GP2013, a rituximab biosimilar candidate, which demonstrated PK and PD bioequivalence to reference product in three different dosing regimens in cynomolgus monkeys. Infliximab, etanercept and rituximab biosimilar candidates have demonstrated PK bioequivalence in the trials included in this review. CT-P13 has recently been approved for use in the European market and the remaining biosimilar candidates are currently being tested in patients with rheumatoid arthritis.

Integrative analysis to select cancer candidate biomarkers to targeted validation

Science.gov (United States)

Heberle, Henry; Domingues, Romênia R.; Granato, Daniela C.; Yokoo, Sami; Canevarolo, Rafael R.; Winck, Flavia V.; Ribeiro, Ana Carolina P.; Brandão, Thaís Bianca; Filgueiras, Paulo R.; Cruz, Karen S. P.; Barbuto, José Alexandre; Poppi, Ronei J.; Minghim, Rosane; Telles, Guilherme P.; Fonseca, Felipe Paiva; Fox, Jay W.; Santos-Silva, Alan R.; Coletta, Ricardo D.; Sherman, Nicholas E.; Paes Leme, Adriana F.

2015-01-01

Targeted proteomics has flourished as the method of choice for prospecting for and validating potential candidate biomarkers in many diseases. However, challenges still remain due to the lack of standardized routines that can prioritize a limited number of proteins to be further validated in human samples. To help researchers identify candidate biomarkers that best characterize their samples under study, a well-designed integrative analysis pipeline, comprising MS-based discovery, feature selection methods, clustering techniques, bioinformatic analyses and targeted approaches was performed using discovery-based proteomic data from the secretomes of three classes of human cell lines (carcinoma, melanoma and non-cancerous). Three feature selection algorithms, namely, Beta-binomial, Nearest Shrunken Centroids (NSC), and Support Vector Machine-Recursive Features Elimination (SVM-RFE), indicated a panel of 137 candidate biomarkers for carcinoma and 271 for melanoma, which were differentially abundant between the tumor classes. We further tested the strength of the pipeline in selecting candidate biomarkers by immunoblotting, human tissue microarrays, label-free targeted MS and functional experiments. In conclusion, the proposed integrative analysis was able to pre-qualify and prioritize candidate biomarkers from discovery-based proteomics to targeted MS. PMID:26540631

Emotional and Affective Temperaments in Smoking Candidates for Bariatric Surgery.

Science.gov (United States)

Mombach, Karin Daniele; de Souza Brito, Cesar Luis; Padoin, Alexandre Vontobel; Casagrande, Daniela Schaan; Mottin, Claudio Cora

2016-01-01

The prevalence of smoking habits in severe obesity is higher than in the general population. There is some evidence that smokers have different temperaments compared to non-smokers. The aim of this study is to evaluate the associations between smoking status (smokers, ex-smokers and non-smokers) and temperament characteristics in bariatric surgery candidates. We analyzed data on temperament of 420 bariatric surgery candidates, as assessed by the AFECTS scale, in an exploratory cross-sectional survey of bariatric surgery candidates who have been grouped into smokers, ex-smokers and non-smokers. We detected significant statistical differences in temperament related to the smoking status in this population after controlling the current use of psychiatric medication. Smokers had higher anxiety and lower control than non-smokers. Ex-smokers with BMI >50 kg/m(2) presented higher coping and control characteristics than smokers. Smoking in bariatric surgery candidates was associated with lower control and higher anxious temperament, when controlled by current use of psychiatric medication. Smokers with BMI >50 kg/m(2) presented lower coping and control than ex-smokers. Assessment of temperament in bariatric surgery candidates may help in decisions about smoking cessation treatment and prevention of smoking relapse after surgery.

On security arguments of the second round SHA-3 candidates

DEFF Research Database (Denmark)

Andreeva, Elena; Bogdanov, Andrey; Mennink, Bart

2012-01-01

of which got accepted to the first round. 14 candidates were left in the second round, out of which five candidates have been recently chosen for the final round. An important criterion in the selection process is the SHA-3 hash function security. We identify two important classes of security arguments...... for the new designs: (1) the possible reductions of the hash function security to the security of its underlying building blocks and (2) arguments against differential attack on building blocks. In this paper, we compare the state of the art provable security reductions for the second round candidates...... and review arguments and bounds against classes of differential attacks.We discuss all the SHA-3 candidates at a high functional level, analyze, and summarize the security reduction results and bounds against differential attacks. Additionally, we generalize the well-known proof of collision resistance...

Class Teacher Candidates' Opinions on Genetically Modified Organisms (GMO)

Science.gov (United States)

Ural Keles, Pinar; Aydin, Suleyman

2017-01-01

This study was conducted to determine the Class teacher candidates' opinions on Genetically Modified Organisms. The study was carried out with 101 teacher candidates who were studying in the 3rd grade of Agri Ibrahim Çeçen University Classroom Teacher Department in 2016-2017 academic year. Of the students who participated in the survey, 56 were…

Predonation screening of candidate donors and prevention of window period donations.

Science.gov (United States)

Lieshout-Krikke, Ryanne W; Zaaijer, Hans L; van de Laar, Thijs J W

2015-02-01

Infectious window period donations slip through routine donor screening procedures. To explore the potential value of predonation screening of candidate donors, we compared the proportion of incident transfusion-transmissible infections in candidate donors, in first-time donors, and in repeat donors. A retrospective analysis was performed of all incident hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) infections in candidate, first-time, and repeat donors in the Netherlands during the period 2009 to 2013. In total, 176,716 candidate donors, 144,226 first-time donations, and 4,143,455 repeat donations were screened for HBV, HCV, and HIV infection. Acute HBV infection was identified in the predonation sample of six candidate donors. One first-time donor, testing HIV-negative at predonation screening, tested positive for anti-HIV and HIV RNA in the first donation 29 days later. Among repeat donations we identified 15, one, and six incident HBV, HCV and HIV infections, respectively. The proportion of incident infections among candidate donors/first-time donations/repeat donations was for HBV, 3.40/0/0.36; for HCV, 0/0/0.02; and for HIV 0/0.69/0.14 per 100,000, respectively. Predonation screening of candidate donors very likely causes a loss of donations, but it might prevent undetected window period donations. Further studies are necessary to determine the value of predonation screening as an additional safety measure. © 2014 AABB.

Teacher Candidate Selection and Evaluation.

Science.gov (United States)

Collins, Mary Lynn; And Others

Summaries are presented of three papers presented at a summer workshop on Quality Assurance in Teacher Education conducted by the Association of Teacher Educators. The general topic covered by these presentations was teacher candidate selection and evaluation. Papers focused upon the following questions: (1) What entry level criteria should be…

Candidate genes detected in transcriptome studies are strongly dependent on genetic background.

Directory of Open Access Journals (Sweden)

Pernille Sarup

2011-01-01

Full Text Available Whole genome transcriptomic studies can point to potential candidate genes for organismal traits. However, the importance of potential candidates is rarely followed up through functional studies and/or by comparing results across independent studies. We have analysed the overlap of candidate genes identified from studies of gene expression in Drosophila melanogaster using similar technical platforms. We found little overlap across studies between putative candidate genes for the same traits in the same sex. Instead there was a high degree of overlap between different traits and sexes within the same genetic backgrounds. Putative candidates found using transcriptomics therefore appear very sensitive to genetic background and this can mask or override effects of treatments. The functional importance of putative candidate genes emerging from transcriptome studies needs to be validated through additional experiments and in future studies we suggest a focus on the genes, networks and pathways affecting traits in a consistent manner across backgrounds.

Rethinking stereotype reliance. Understanding the connection between female candidates and gender stereotypes.

Science.gov (United States)

Bauer, Nichole M

2013-01-01

Increasing numbers of female candidates are running for Congress in American national elections. Despite the rise in female candidates running for office, women are not significantly increasing their presence in the House and Senate. A much hypothesized influence over the electoral fates of female candidates is the role of gender stereotypes. However, political science scholars have struggled to pinpoint the effect of stereotypes on vote choice, if there is any effect. This essay compares the way social psychology and political science scholars theoretically, conceptually and empirically test for gender stereotype influence over evaluations of female candidates and politicians. Differences emerge in the theoretical assumptions made in the two disciplines, the types of measures used in research, and the empirical tests conducted to demonstrate the presence or absence of stereotypes in evaluations of women. The discussion explores how scholars studying female candidates and politicians can integrate insights from social psychology to clarify the role of stereotypes in candidate evaluation and choice.

Candidate gene studies and the quest for the entrepreneurial gene

NARCIS (Netherlands)

M.J.H.M. van der Loos (Matthijs); Ph.D. Koellinger (Philipp); P.J.F. Groenen (Patrick); C.A. Rietveld (Niels); F. Rivadeneira Ramirez (Fernando); F.J.A. van Rooij (Frank); A.G. Uitterlinden (André); A. Hofman (Albert); A.R. Thurik (Roy)

2011-01-01

textabstractCandidate gene studies of human behavior are gaining interest in economics and entrepreneurship research. Performing and interpreting these studies is not straightforward because the selection of candidates influences the interpretation of the results. As an example, Nicolaou et al.

Qualitative analysis of MMI raters' scorings of medical school candidates: A matter of taste?

Science.gov (United States)

Christensen, Mette K; Lykkegaard, Eva; Lund, Ole; O'Neill, Lotte D

2018-05-01

Recent years have seen leading medical educationalists repeatedly call for a paradigm shift in the way we view, value and use subjectivity in assessment. The argument is that subjective expert raters generally bring desired quality, not just noise, to performance evaluations. While several reviews document the psychometric qualities of the Multiple Mini-Interview (MMI), we currently lack qualitative studies examining what we can learn from MMI raters' subjectivity. The present qualitative study therefore investigates rater subjectivity or taste in MMI selection interview. Taste (Bourdieu 1984) is a practical sense, which makes it possible at a pre-reflective level to apply 'invisible' or 'tacit' categories of perception for distinguishing between good and bad. The study draws on data from explorative in-depth interviews with 12 purposefully selected MMI raters. We find that MMI raters spontaneously applied subjective criteria-their taste-enabling them to assess the candidates' interpersonal attributes and to predict the candidates' potential. In addition, MMI raters seemed to share a taste for certain qualities in the candidates (e.g. reflectivity, resilience, empathy, contact, alikeness, 'the good colleague'); hence, taste may be the result of an ongoing enculturation in medical education and healthcare systems. This study suggests that taste is an inevitable condition in the assessment of students' performance. The MMI set-up should therefore make room for MMI raters' taste and their connoisseurship, i.e. their ability to taste, to improve the quality of their assessment of medical school candidates.

A study on the safety of spent fuel management. A scenario study on spent fuel management

Energy Technology Data Exchange (ETDEWEB)

Chun, Kwan Sik; Park, Hyun Soo; Ahn, Jin Soo; Hwang, Joo Ho; Choi, Jong Won; Kim, Yeon Soo; Park, Ju Hwan; Chung, Choong Hwan [Korea Atomic Energy Research Inst., Daeduk (Korea, Republic of)

1992-03-01

In order to produce data applicable for the long-term policy making of spent fuel management and to suggest a basic scenario suitable to domestic situation, the pre-conceptual design of reference disposal facilities for the spent fuel and the vitrified high level radioactive waste from its reprocessing, has been performed. From the results of the pre-conceptual study, further research and development areas to accumulate the disposal technology are suggested. In addition, the physico-chemical properties and functional characteristics of domestic bentonite are analyzed to assess its applicability as a buffer material which would play a major role for the safe disposal of highly active waste including spent fuels. (Author).

Spectroscopic monitoring of bright A-F type candidate hybrid stars discovered by the Kepler mission

Science.gov (United States)

Lampens, Patricia; Frémat, Y.; Vermeylen, Lore; De Cat, Peter; Dumortier, Louis; Sódor, Ádám; Sharka, Marek; Bognár, Zsófia

2018-04-01

We report on a study of 250 optical spectra for 50 bright A/F-type candidate hybrid pulsating stars from the Kepler field. Most of the spectra have been collected with the high-resolution spectrograph HERMES attached to the Mercator telescope, La Palma. We determined the radial velocities (RVs), projected rotational velocities, fundamental atmospheric parameters and provide a classification based on the appearance of the cross-correlation profiles and the behaviour of the RVs with time in order to find true hybrid pulsators. Additionally, we also detected new spectroscopic binary and multiple systems in our sample and determined the fraction of spectroscopic systems. In order to be able to extend this investigation to the fainter A-F type candidate hybrid stars, various high-quality spectra collected with 3-4 m sized telescopes suitably equipped with a high-resolution spectrograph and furthermore located in the Northern hemisphere would be ideal. This programme could be done using the new instruments installed at the Devasthal Observatory.

Oral Candidal Carriage in Subjects with Pure Vegetarian and Mixed Dietary Habits.

Science.gov (United States)

Patil, Shankargouda; Rao, Roopa S; Raj, A Thirumal; Sanketh, D S; Sarode, Sachin; Sarode, Gargi

2017-07-01

Candida albicans being a part of the normal oral microbial flora is one of the most commonly isolated species from the oral cavity. Recent studies have shown a steady rise in the number of non C. albicans species, which are relatively resistant to common antifungal agents and are being recognized as potential pathogens. It is vital to ascertain the predisposing factors leading to such a shift in the oral candidal flora. To estimate the prevalence of candidal species among vegetarians and non-vegetarians. Clinical data including age, gender, and diet preference of 238 participants were noted. Participants with a history of systemic disorders, oral prosthesis, salivary gland disorders and habits such as smoking, alcoholism, and tobacco usage were excluded from the study. The participants were asked to gargle a 10 ml solution of phosphate buffered saline for one minute before depositing the same in a sterile container. The samples were cultured using Hicrome agar media. Data analysis was carried out using Statistical Package for Social Sciences (SPSS software) version 10.5 and differences between individual groups were tested by Chi-square test. Among 238 samples, 127 (53.3%) samples were positive for Candida . The candidal prevalence in vegetarians (68.5%) was higher than non-vegetarians (40.7%). C. albicans was the most common species to be isolated in both vegetarians (35.1%) and non-vegetarians (39.2%). Candida glabrata and Candida tropicalis showed a higher prevalence in vegetarians (30.5% and 10.1%, respectively) in comparison to non-vegetarians (8.4% and 2.3%, respectively). Candida krusei was isolated only from vegetarians (4.6%). Results indicate that diet plays a major role in oral candidal prevalence and species specificity which in turn may predispose the vegetarians toward these pathogenic organisms.

Automatic vetting of planet candidates from ground based surveys: Machine learning with NGTS

Science.gov (United States)

Armstrong, David J.; Günther, Maximilian N.; McCormac, James; Smith, Alexis M. S.; Bayliss, Daniel; Bouchy, François; Burleigh, Matthew R.; Casewell, Sarah; Eigmüller, Philipp; Gillen, Edward; Goad, Michael R.; Hodgkin, Simon T.; Jenkins, James S.; Louden, Tom; Metrailler, Lionel; Pollacco, Don; Poppenhaeger, Katja; Queloz, Didier; Raynard, Liam; Rauer, Heike; Udry, Stéphane; Walker, Simon R.; Watson, Christopher A.; West, Richard G.; Wheatley, Peter J.

2018-05-01

State of the art exoplanet transit surveys are producing ever increasing quantities of data. To make the best use of this resource, in detecting interesting planetary systems or in determining accurate planetary population statistics, requires new automated methods. Here we describe a machine learning algorithm that forms an integral part of the pipeline for the NGTS transit survey, demonstrating the efficacy of machine learning in selecting planetary candidates from multi-night ground based survey data. Our method uses a combination of random forests and self-organising-maps to rank planetary candidates, achieving an AUC score of 97.6% in ranking 12368 injected planets against 27496 false positives in the NGTS data. We build on past examples by using injected transit signals to form a training set, a necessary development for applying similar methods to upcoming surveys. We also make the autovet code used to implement the algorithm publicly accessible. autovet is designed to perform machine learned vetting of planetary candidates, and can utilise a variety of methods. The apparent robustness of machine learning techniques, whether on space-based or the qualitatively different ground-based data, highlights their importance to future surveys such as TESS and PLATO and the need to better understand their advantages and pitfalls in an exoplanetary context.

ELECTIONS PENSION FUND CANDIDATE NR 5

CERN Multimedia

2001-01-01

ORGANISATION EUROPEENNE POUR LA RECHERCHE NUCLEAIRE CERN EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH CAISSE DE PENSIONS / PENSION FUND Caisse de Pensions - ELECTIONS - Pension Fund This candidature has been duly registered and is hereby presented in accordance with paragraph 6.h of the Regulations for Elections to the Governing Board of the Pension Fund. Candidate :  Name : Sonnemann  First Name : Florian Since my arrival at CERN in 1997 I have worked in the accelerator and administrative sectors. I have recently been elected as member of the Staff Council and of the Executive Committee of the Staff Association in which I am actively following matters concerning the Pension Fund. My candidature for the Governing Board of the CERN Pension Fund is mainly motivated to add my part in ensuring a solid financial situation of the Pension Fund. The Pension Fund is our only social security system. I wish to play a role in ensuring that the pensions will remain a secure revenue for all staff membe...

ELECTIONS PENSION FUND 5th candidate

CERN Multimedia

2001-01-01

ORGANISATION EUROPEENNE POUR LA RECHERCHE NUCLEAIRE CERN EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH CAISSE DE PENSIONS / PENSION FUND Caisse de Pensions - ELECTIONS - Pension Fund This candidature has been duly registered and is hereby presented in accordance with paragraph 6.h of the Regulations for Elections to the Governing Board of the Pension Fund. Candidate :  Name : Sonnemann  First Name : Florian Since my arrival at CERN in 1997 I have worked in the accelerator and administrative sectors. I have recently been elected as member of the Staff Council and of the Executive Committee of the Staff Association in which I am actively following matters concerning the Pension Fund. My candidature for the Governing Board of the CERN Pension Fund is mainly motivated to add my part in ensuring a solid financial situation of the Pension Fund. The Pension Fund is our only social security system. I wish to play a role in ensuring that the pensions will remain a secure revenue for all staff membe...

LR1: a candidate RNA virus of Leishmania.

OpenAIRE

Tarr, P I; Aline, R F; Smiley, B L; Scholler, J; Keithly, J; Stuart, K

1988-01-01

Although viruses are important biological agents and useful molecular tools, little is known about the viruses of parasites. We report here the discovery of a candidate for an RNA virus in a kinetoplastid parasite. This potential virus, which we term LR1, is present in the promastigote form of the human pathogen Leishmania braziliensis guyanensis CUMC1-1A but not in 11 other stocks of Leishmania that were examined nor in Trypanosoma brucei. The candidate viral RNA has a size of approximately ...

An Experimental Investigation of Leak Rate Performance of a Subscale Candidate Elastomer Docking Space Seal

Science.gov (United States)

Garafolo, Nicholas G.; Daniels, Christopher C.

2011-01-01

A novel docking seal was developed for the main interface seal of NASA s Low Impact Docking System (LIDS). This interface seal was designed to maintain acceptable leak rates while being exposed to the harsh environmental conditions of outer space. In this experimental evaluation, a candidate docking seal assembly called Engineering Development Unit (EDU58) was characterized and evaluated against the Constellation Project leak rate requirement. The EDU58 candidate seal assembly was manufactured from silicone elastomer S0383-70 vacuum molded in a metal retainer ring. Four seal designs were considered with unique characteristic heights. The leak rate performance was characterized through a mass point leak rate method by monitoring gas properties within an internal control volume. The leakage performance of the seals were described herein at representative docking temperatures of -50, +23, and +50 C for all four seal designs. Leak performance was also characterized at 100, 74, and 48 percent of full closure. For all conditions considered, the candidate seal assemblies met the Constellation Project leak rate requirement.

TIME-SERIES SPECTROSCOPY OF TWO CANDIDATE DOUBLE DEGENERATES IN THE OPEN CLUSTER NGC 6633

Energy Technology Data Exchange (ETDEWEB)

Williams, Kurtis A.; Chakraborty, Subho [Department of Physics and Astrophysics, Texas A and M University-Commerce, P.O. Box 3011, Commerce, TX, 75429 (United States); Serna-Grey, Donald [Department of Astronomy, University of Washington, Box 351580, Seattle, WA, 98195 (United States); Gianninas, A.; Canton, Paul A., E-mail: Kurtis.Williams@tamuc.edu [Homer L. Dodge Department of Physics and Astronomy, University of Oklahoma, 440 W. Brooks St., Norman, OK, 73019 (United States)

2015-12-15

SNe Ia are heavily used tools in precision cosmology, yet we still are not certain what the progenitor systems are. General plausibility arguments suggest there is potential for identifying double degenerate SN Ia progenitors in intermediate-age open star clusters. We present time-resolved high-resolution spectroscopy of two white dwarfs (WDs) in the field of the open cluster NGC 6633 that had previously been identified as candidate double degenerates in the cluster. However, three hours of continuous observations of each candidate failed to detect any significant radial velocity variations at the ≳10 km s{sup −1} level, making it highly unlikely that either WD is a double degenerate that will merge within a Hubble Time. The WD LAWDS NGC 6633 4 has a radial velocity inconsistent with cluster membership at the 2.5σ level, while the radial velocity of LAWDS NGC 6633 7 is consistent with cluster membership. We conservatively conclude that LAWDS 7 is a viable massive double degenerate candidate, though unlikely to be a Type Ia progenitor. Astrometric data from GAIA will likely be needed to determine if either WD is truly a cluster member.

Linkage mapping of candidate genes for induce resistance and growth promotion by trichoderma koningiopsis (th003) in tomato solanum lycopersicum

International Nuclear Information System (INIS)

Simbaqueba, Jaime; Cotes, Alba Marina; Barrero, Luz Stella

2011-01-01

Induced systemic resistance (ISR) is a mechanism by which plants enhance defenses against any stress condition. ISR and growth promotion are enhanced when tomato (Solanum lycopersicum) is inoculated with several strains of Trichoderma ssp. this study aims to genetically map tomato candidate genes involved in ISR and growth promotion induced by the Colombian native isolate Trichoderma koningiopsis th003. Forty-nine candidate genes previously identified on tomato plants treated with th003 and T. hamatum T382 strains were evaluated for polymorphisms and 16 of them were integrated on the highly saturated genetic linkage map named TOMATO EXPEN 2000. The location of six unigenes was similar to the location of resistance gene analogs (RGAS), defense related ests and resistance QTLs previously reported, suggesting new possible candidates for these quantitative trait loci (QTL) regions. The candidate gene-markers may be used for future ISR or growth promotion assisted selection in tomato.

FUNDAMENTAL PROPERTIES OF KEPLER PLANET-CANDIDATE HOST STARS USING ASTEROSEISMOLOGY

Energy Technology Data Exchange (ETDEWEB)

Huber, Daniel; Lissauer, Jack J.; Rowe, Jason F. [NASA Ames Research Center, Moffett Field, CA 94035 (United States); Chaplin, William J. [School of Physics and Astronomy, University of Birmingham, Birmingham B15 2TT (United Kingdom); Christensen-Dalsgaard, Jorgen; Kjeldsen, Hans; Handberg, Rasmus; Karoff, Christoffer; Lund, Mikkel N.; Lundkvist, Mia [Stellar Astrophysics Centre, Department of Physics and Astronomy, Aarhus University, Ny Munkegade 120, DK-8000 Aarhus C (Denmark); Gilliland, Ronald L. [Center for Exoplanets and Habitable Worlds, The Pennsylvania State University, 525 Davey Lab, University Park, PA 16802 (United States); Buchhave, Lars A. [Niels Bohr Institute, University of Copenhagen, DK-2100 Copenhagen (Denmark); Fischer, Debra A.; Basu, Sarbani [Department of Astronomy, Yale University, New Haven, CT 06511 (United States); Sanchis-Ojeda, Roberto [Department of Physics, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139 (United States); Hekker, Saskia [Astronomical Institute ' ' Anton Pannekoek' ' , University of Amsterdam, Science Park 904, 1098 XH Amsterdam (Netherlands); Howard, Andrew W. [Institute for Astronomy, University of Hawaii, 2680 Woodlawn Drive, Honolulu, HI 96822 (United States); Isaacson, Howard; Marcy, Geoffrey W. [Department of Astronomy, University of California, Berkeley, CA 94720 (United States); Latham, David W., E-mail: daniel.huber@nasa.gov [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States); and others

2013-04-20

We have used asteroseismology to determine fundamental properties for 66 Kepler planet-candidate host stars, with typical uncertainties of 3% and 7% in radius and mass, respectively. The results include new asteroseismic solutions for four host stars with confirmed planets (Kepler-4, Kepler-14, Kepler-23 and Kepler-25) and increase the total number of Kepler host stars with asteroseismic solutions to 77. A comparison with stellar properties in the planet-candidate catalog by Batalha et al. shows that radii for subgiants and giants obtained from spectroscopic follow-up are systematically too low by up to a factor of 1.5, while the properties for unevolved stars are in good agreement. We furthermore apply asteroseismology to confirm that a large majority of cool main-sequence hosts are indeed dwarfs and not misclassified giants. Using the revised stellar properties, we recalculate the radii for 107 planet candidates in our sample, and comment on candidates for which the radii change from a previously giant-planet/brown-dwarf/stellar regime to a sub-Jupiter size or vice versa. A comparison of stellar densities from asteroseismology with densities derived from transit models in Batalha et al. assuming circular orbits shows significant disagreement for more than half of the sample due to systematics in the modeled impact parameters or due to planet candidates that may be in eccentric orbits. Finally, we investigate tentative correlations between host-star masses and planet-candidate radii, orbital periods, and multiplicity, but caution that these results may be influenced by the small sample size and detection biases.

76 FR 4896 - Call for Candidates

Science.gov (United States)

2011-01-27

... designated to establish generally accepted accounting principles for federal government entities. Generally, non-federal Board members are selected from the general financial community, the accounting and... FEDERAL ACCOUNTING STANDARDS ADVISORY BOARD Call for Candidates AGENCY: Federal Accounting...

Candidate Political Philosophy: Revelations in the 1960 and 1976 Debates.

Science.gov (United States)

Meadow, Robert G.; Jackson-Beeck, Marilyn

Since voters rarely have access to a candidate's unexpurgated statements, they rely on political advertising, film footage, and media interpretations. Thus, their expectations of candidates generally reflect selective reporting and self-aggrandizement. A framework for researching the degree of understanding reached between politicians and the…

A CATALOG OF MOVING GROUP CANDIDATES IN THE SOLAR NEIGHBORHOOD

International Nuclear Information System (INIS)

Zhao Jingkun; Zhao Gang; Chen Yuqin

2009-01-01

Based on the kernel estimator and wavelet technique, we have identified 22 moving group candidates in the solar neighborhood from a sample which includes around 14,000 dwarfs and 6000 giants. Six of them were previously known as the Hercules stream, the Sirus-UMa stream, the Hyades stream, the Caster group, the Pleiades stream, and the IC 2391; five of them have also been reported by other authors. 11 moving group candidates, not previously reported in the literature, show prominent structures in dwarf or giant samples. A catalog of moving group candidates in the solar neighborhood is presented in this work.

Nuclear safety in EU candidate countries

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-10-01

Nuclear safety in the candidate countries to the European Union is a major issue that needs to be addressed in the framework of the enlargement process. Therefore WENRA members considered it was their duty to offer their technical assistance to their Governments and the European Union Institutions. They decided to express their collective opinion on nuclear safety in those candidate countries having at least one nuclear power plant: Bulgaria, the Czech Republic, Hungary, Lithuania, Romania, Slovakia and Slovenia. The report is structured as follows: A foreword including background information, structure of the report and the methodology used, General conclusions of WENRA members reflecting their collective opinion, For each candidate country, an executive summary, a chapter on the status of the regulatory regime and regulatory body, and a chapter on the nuclear power plant safety status. Two annexes are added to address the generic safety characteristics and safety issues for RBMK and VVER plants. The report does not cover radiation protection and decommissioning issues, while safety aspects of spent fuel and radioactive waste management are only covered as regards on-site provisions. In order to produce this report, WENRA used different means: For the chapters on the regulatory regimes and regulatory bodies, experts from WENRA did the work. For the chapters on nuclear power plant safety status, experts from WENRA and from French and German technical support organisations did the work. Taking into account the contents of these chapters, WENRA has formulated its general conclusions in this report.

Nuclear safety in EU candidate countries

International Nuclear Information System (INIS)

2000-10-01

Nuclear safety in the candidate countries to the European Union is a major issue that needs to be addressed in the framework of the enlargement process. Therefore WENRA members considered it was their duty to offer their technical assistance to their Governments and the European Union Institutions. They decided to express their collective opinion on nuclear safety in those candidate countries having at least one nuclear power plant: Bulgaria, the Czech Republic, Hungary, Lithuania, Romania, Slovakia and Slovenia. The report is structured as follows: A foreword including background information, structure of the report and the methodology used, General conclusions of WENRA members reflecting their collective opinion, For each candidate country, an executive summary, a chapter on the status of the regulatory regime and regulatory body, and a chapter on the nuclear power plant safety status. Two annexes are added to address the generic safety characteristics and safety issues for RBMK and VVER plants. The report does not cover radiation protection and decommissioning issues, while safety aspects of spent fuel and radioactive waste management are only covered as regards on-site provisions. In order to produce this report, WENRA used different means: For the chapters on the regulatory regimes and regulatory bodies, experts from WENRA did the work. For the chapters on nuclear power plant safety status, experts from WENRA and from French and German technical support organisations did the work. Taking into account the contents of these chapters, WENRA has formulated its general conclusions in this report

Designation of teacher candidates self-efficacy and success level about designing multimedia

OpenAIRE

Vasfi Tugun; Fezile Özdamlı

2016-01-01

This research aims to determine the self-efficacy and success levels of teacher candidates on developing multimedia to the Docebo learning management system through integrating various online tools in developing multimedia course and using this method in project-based learning process. Second year students from the department of Computer Education and Educational Technology participated in this research. Random selection method was used in order to assign the students to the groups. Online (3...

Transit timing observations from Kepler. V. Transit timing variation candidates in the first sixteen months from polynomial models

DEFF Research Database (Denmark)

Ford, E.B.; Ragozzine, D.; Holman, M.J.

2012-01-01

Transit timing variations provide a powerful tool for confirming and characterizing transiting planets, as well as detecting non-transiting planets. We report the results of an updated transit timing variation (TTV) analysis for 1481 planet candidates based on transit times measured during...... that several of these planet candidates could be confirmed and perhaps characterized with more detailed TTV analyses using publicly available Kepler observations. For many others, Kepler has observed a long-term TTV trend, but an extended Kepler mission will be required to characterize the system via TTVs. We...

ASASSN-16dt and ASASSN-16hg: Promising candidate period bouncers

Science.gov (United States)

Kimura, Mariko; Isogai, Keisuke; Kato, Taichi; Taguchi, Kenta; Wakamatsu, Yasuyuki; Hambsch, Franz-Josef; Monard, Berto; Myers, Gordon; Dvorak, Shawn; Starr, Peter; Brincat, Stephen M.; de Miguel, Enrique; Ulowetz, Joseph; Itoh, Hiroshi; Stone, Geoff; Nogami, Daisaku

2018-04-01

We present optical photometry of superoutbursts that occurred in 2016 of two WZ Sge-type dwarf novae (DNe), ASASSN-16dt and ASASSN-16hg. Their light curves showed a dip in brightness between the first plateau stage with no ordinary superhumps (or early superhumps) and the second plateau stage with ordinary superhumps. We find that the dip is produced by the slow evolution of the 3 : 1 resonance tidal instability and that it would likely be observed in low mass-ratio objects. An estimated mass ratio (q ≡ M2/M1) from the period of developing (stage A) superhumps [0.06420(3) d] was 0.036(2) in ASASSN-16dt. Additionally, its superoutburst has many properties similar to those in other low-q WZ Sge-type DNe: long-lasting stage-A superhumps, small superhump amplitudes, long delay of ordinary-superhump appearances, and a slow decline rate in the plateau stage with superhumps. Its very small mass ratio and observational characteristics suggest that this system is one of the best candidates for a period bouncer—a binary accounting for the missing population of post-period minimum cataclysmic variables. Although it is not clearly verified due to the lack of detection of stage-A superhumps, ASASSN-16hg might be a possible candidate for period bouncers on the basis of the morphology of its light curves and the small superhump amplitudes. Many outburst properties of period bouncer candidates would originate from the small tidal effects of their secondary stars.

A Study on Teacher Candidates' Competencies in Classroom Management

Science.gov (United States)

Selçuk, Gülenaz; Kadi, Aysegül; Yildirim, Remzi; Çelebi, Nurhayat

2017-01-01

The objective of this paper is to examine competencies in classroom management of teacher candidates. Research design was determined as pre-experimental research design. Research was conducted with 388 teacher candidates. In this research, these were found; Attitudes of students about competencies in classroom management differ according to…

Candidate Quality Measures for Hand Surgery.

Science.gov (United States)

2017-11-01

Quality measures are tools used by physicians, health care systems, and payers to evaluate performance, monitor the outcomes of interventions, and inform quality improvement efforts. A paucity of quality measures exist that address hand surgery care. We completed a RAND/UCLA (University of California Los Angeles) Delphi Appropriateness process with the goal of developing and evaluating candidate hand surgery quality measures to be used for national quality measure development efforts. A consortium of 9 academic upper limb surgeons completed a RAND/UCLA Delphi Appropriateness process to evaluate the importance, scientific acceptability, usability, and feasibility of 44 candidate quality measures. These addressed hand problems the panelists felt were most appropriate for quality measure development. Panelists rated the measures on an ordinal scale between 1 (definitely not valid) and 9 (definitely valid) in 2 rounds (preliminary round and final round) with an intervening face-to-face discussion. Ratings from 1 to 3 were considered not valid, 4 to 6 as equivocal or uncertain, and 7 to 9 as valid. If no more than 2 of the 9 ratings were outside the 3-point range that included the median (1-3, 4-6, or 7-9), the panelists were considered to be in agreement. If 3 or more of the panelists' ratings of a measure were within the 1 to 3 range and 3 or more ratings were in the 7 to 9 range, the panelists were considered to be in disagreement. There was agreement on 43% (19) of the measures as important, 27% (12) as scientifically sound, 48% (21) as usable, and 59% (26) as feasible to complete. Ten measures met all 4 of these criteria and were, therefore, considered valid measurements of quality. Quality measures that were developed address outcomes (patient-reported outcomes for assessment and improvement of function) and processes of care (utilization rates of imaging, antibiotics, occupational therapy, ultrasound, and operative treatment). The consortium developed 10

SINGLE-LINED SPECTROSCOPIC BINARY STAR CANDIDATES IN THE RAVE SURVEY

International Nuclear Information System (INIS)

Matijevic, G.; Zwitter, T.; Bienayme, O.; Siebert, A.; Watson, F. G.; Bland-Hawthorn, J.; Parker, Q. A.; Freeman, K. C.; Gilmore, G.; Grebel, E. K.; Helmi, A.; Munari, U.; Siviero, A.; Navarro, J. F.; Reid, W.; Seabroke, G. M.; Steinmetz, M.; Williams, M.; Wyse, R. F. G.

2011-01-01

Repeated spectroscopic observations of stars in the RAdial Velocity Experiment (RAVE) database are used to identify and examine single-lined binary (SB1) candidates. The RAVE latest internal database (VDR3) includes radial velocities, atmospheric parameters, and other parameters for approximately a quarter of a million different stars with slightly less than 300,000 observations. In the sample of ∼20,000 stars observed more than once, 1333 stars with variable radial velocities were identified. Most of them are believed to be SB1 candidates. The fraction of SB1 candidates among stars with several observations is between 10% and 15% which is the lower limit for binarity among RAVE stars. Due to the distribution of time spans between the re-observation that is biased toward relatively short timescales (days to weeks), the periods of the identified SB1 candidates are most likely in the same range. Because of the RAVE's narrow magnitude range most of the dwarf candidates belong to the thin Galactic disk while the giants are part of the thick disk with distances extending to up to a few kpc. The comparison of the list of SB1 candidates to the VSX catalog of variable stars yielded several pulsating variables among the giant population with radial velocity variations of up to few tens of km s -1 . There are 26 matches between the catalog of spectroscopic binary orbits (S B 9 ) and the whole RAVE sample for which the given periastron time and the time of RAVE observation were close enough to yield a reliable comparison. RAVE measurements of radial velocities of known spectroscopic binaries are consistent with their published radial velocity curves.

Characterisation of five candidate genes within the ETEC F4ab/ac candidate region in pigs

DEFF Research Database (Denmark)

Jacobsen, Mette Juul; Cirera Salicio, Susanna; Joller, David

2011-01-01

by haplotype sharing to a 2.5 Mb region on pig chromosome 13, a region containing 18 annotated genes. FINDINGS: The coding regions of five candidate genes for susceptibility to ETEC F4ab/ac infection (TFRC, ACK1, MUC20, MUC4 and KIAA0226), all located in the 2.5 Mb region, were investigated for the presence...... polymorphism in exon 22 of KIAA0226. Transcriptional profiles of the five genes were investigated in a porcine tissue panel including various intestinal tissues. All five genes were expressed in intestinal tissues at different levels but none of the genes were found differentially expressed between ETEC F4ab/ac...... of the amino acids composition. However, we cannot exclude that the five tested genes are bona fide candidate genes for susceptibility to ETEC F4ab/ac infection since the identified polymorphism might affect the translational apparatus, alternative splice forms may exist and post translational mechanisms might...

Discriminating dark matter candidates using direct detection

International Nuclear Information System (INIS)

Belanger, G.; Nezri, E.; Pukhov, A.

2009-01-01

We examine the predictions for both the spin-dependent and spin-independent direct detection rates in a variety of new particle physics models with dark matter candidates. We show that a determination of both spin-independent and spin-dependent amplitudes on protons and neutrons can in principle discriminate different candidates of dark matter up to a few ambiguities. We emphasize the importance of making measurements with different spin-dependent sensitive detector materials and the need for significant improvement of the detector sensitivities. Scenarios where exchange of new colored particles contributes significantly to the elastic scattering cross sections are often the most difficult to identify, the LHC should give an indication whether such scenarios are relevant for direct detection.

Preliminary Analysis and Selection of Mooring Solution Candidates

DEFF Research Database (Denmark)

Thomsen, Jonas Bjerg; Delaney, Martin

This report covers a preliminary analysis of mooring solutions candidates for four large floating wave energy converters. The work is part of the EUDP project “Mooring Solutions for Large Wave Energy Converters” and is the outcome of "Work Package 3: Preliminary Analysis". The report further...... compose the "Milestone 4: Report on results of preliminary analysis and selection of final candidates. The report is produced by Aalborg University with input from the partner WECs Floating Power Plant, KNSwing, LEANCON and Wave Dragon. Tension Technology International (TTI) has provided a significant...

Many-Objective Distinct Candidates Optimization using Differential Evolution

DEFF Research Database (Denmark)

Justesen, Peter; Ursem, Rasmus Kjær

2010-01-01

for each objective. The Many-Objective Distinct Candidates Optimization using Differential Evolution (MODCODE) algorithm takes a novel approach by focusing search using a user-defined number of subpopulations each returning a distinct optimal solution within the preferred region of interest. In this paper......, we present the novel MODCODE algorithm incorporating the ROD measure to measure and control candidate distinctiveness. MODCODE is tested against GDE3 on three real world centrifugal pump design problems supplied by Grundfos. Our algorithm outperforms GDE3 on all problems with respect to all...

Fostering the Development of Chemistry Teacher Candidates: A Bioecological Approach

Science.gov (United States)

Lewthwaite, Brian; Wiebe, Rick

2012-01-01

This ongoing research inquiry investigates through the analysis of teacher candidate experiences the factors influencing two groups of chemistry teacher candidates' development during their extended practica in their second and final year of an after-degree bachelor of education at a university in central Canada. The tenets of Bronfenbrenner's…

Measuring College Success for International Baccalaureate Diploma and Certificate Candidates

Science.gov (United States)

Hill, Jennifer Coles

2018-01-01

This quantitative study was conducted at a private international high school. The study purpose was to investigate United States college trends comparing International Baccalaureate Diploma Program candidates and International Baccalaureate Non-Diploma Program candidates from the same school in Asia. Data was collected for the Classes of 2007-2012…

Gallium-67 imaging in candidal esophagitis

International Nuclear Information System (INIS)

Rundback, J.H.; Goldfarb, C.R.; Ongseng, F.

1990-01-01

Ga-67 scanning has been used to evaluate esophageal carcinoma. It has demonstrated candidal infection in other body sites and, in one previous case, in the esophagus. The authors present a case of diffuse esophageal uptake of Ga-67 in esophageal candidiasis

47 CFR 73.1942 - Candidate rates.

Science.gov (United States)

2010-10-01

... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES RADIO BROADCAST SERVICES Rules Applicable to All Broadcast Stations § 73.1942 Candidate rates. (a) Charges for use of stations... periods. Any station practices offered to commercial advertisers that enhance the value of advertising...

Gallium-67 imaging in candidal esophagitis

Energy Technology Data Exchange (ETDEWEB)

Rundback, J.H.; Goldfarb, C.R.; Ongseng, F. (Beth Israel Medical Center, New York, NY (USA))

1990-01-01

Ga-67 scanning has been used to evaluate esophageal carcinoma. It has demonstrated candidal infection in other body sites and, in one previous case, in the esophagus. The authors present a case of diffuse esophageal uptake of Ga-67 in esophageal candidiasis.

Examination of Nonchromate Conversion Coatings for Aluminum Armor From Three Final Candidates Using Accelerated Corrosion and Adhesion Test Methods

National Research Council Canada - National Science Library

Placzankis, Brian

2001-01-01

This study examines the effectiveness of three final candidate nonchromate conversion coatings on aluminum alloys 5083, 7039, and 6061 coated with standard solvent-based Chemical Agent Resistant Coating (CARC) system...

Antibody Desensitization Therapy in Highly Sensitized Lung Transplant Candidates

Science.gov (United States)

Snyder, L. D.; Gray, A. L.; Reynolds, J. M.; Arepally, G. M.; Bedoya, A.; Hartwig, M. G.; Davis, R. D.; Lopes, K. E.; Wegner, W. E.; Chen, D. F.; Palmer, S. M.

2015-01-01

As HLAs antibody detection technology has evolved, there is now detailed HLA antibody information available on prospective transplant recipients. Determining single antigen antibody specificity allows for a calculated panel reactive antibodies (cPRA) value, providing an estimate of the effective donor pool. For broadly sensitized lung transplant candidates (cPRA ≥ 80%), our center adopted a pretransplant multimodal desensitization protocol in an effort to decrease the cPRA and expand the donor pool. This desensitization protocol included plasmapheresis, solumedrol, bortezomib and rituximab given in combination over 19 days followed by intravenous immunoglobulin. Eight of 18 candidates completed therapy with the primary reasons for early discontinuation being transplant (by avoiding unacceptable antigens) or thrombocytopenia. In a mixed-model analysis, there were no significant changes in PRA or cPRA changes over time with the protocol. A sub-analysis of the median fluorescence intensity (MFI) change indicated a small decline that was significant in antibodies with MFI 5000–10 000. Nine of 18 candidates subsequently had a transplant. Posttransplant survival in these nine recipients was comparable to other pretransplant-sensitized recipients who did not receive therapy. In summary, an aggressive multi-modal desensitization protocol does not significantly reduce pretransplant HLA antibodies in a broadly sensitized lung transplant candidate cohort. PMID:24666831

A Multi-wavelength Analysis of Binary-AGN Candidate PSO J334.2028+01.4075

OpenAIRE

Foord, Adi; Gultekin, Kayhan; Reynolds, Mark; Ayers, Megan; Liu, Tingting; Gezari, Suvi; Runnoe, Jessie

2017-01-01

We present analysis of the first Chandra observation of PSO J334.2028+01.4075 (PSO J334), targeted as a binary-AGN candidate based on periodic variations of the optical flux. With no prior targeted X-ray coverage for PSO J334, our new 40 ksec Chandra observation allows for the opportunity to differentiate between a single or binary-AGN system, and if a binary, can characterize the mode of accretion. Simulations show that the two expected accretion disk morphologies for binary-AGN systems are ...

Natural Flavonoids as Promising Analgesic Candidates: A Systematic Review.

Science.gov (United States)

Xiao, Xiao; Wang, Xiaoyu; Gui, Xuan; Chen, Lu; Huang, Baokang

2016-11-01

Due to the chemical structural diversity and various analgesic mechanisms, an increasing number of studies indicated that some flavonoids from medicinal plants could be promising candidates for new natural analgesic drugs, which attract high interests of advanced users and academic researchers. The aim of this systematic review is to report flavonoids and its derivatives as new analgesic candidates based on the pharmacological evidences. Sixty-four papers were found concerning the potential analgesic activity of 46 flavonoids. In this case, the evidence for analgesic activity of flavonoids and total flavonoids was investigated. Meanwhile, the corresponding analgesic mechanism of flavonoids was discussed by generalizing and analyzing the current publications. Based on this review, the conclusion can be drawn that some flavonoids are promising candidates for painful conditions and deserve particular attention in further research and development. © 2016 Wiley-VHCA AG, Zurich, Switzerland.

Polymorphism’s assessment of children’s candidate genes associated with low-level long-term exposure to strontium in drinking water

Directory of Open Access Journals (Sweden)

N.V. Zaitseva

2015-12-01

Full Text Available A sequencing of the candidate genes of the pupils, exposed to strontium by the method of targeted resequencing has been performed. It is shown, that under conditions of increased revenues of strontium in drinking water the number of polymorphonuclear altered portions of candidate genes increases. As a result of the targeted resequencing in conditions of strontium exposure, the maximum polymorph modifications of the following genes are defined: sulfotransferase 1A1 (SULT1A1 and methylenetetrahydrofolate. It was shown that the structure of the mutations in conditions of the strontium exposure was characterized by the formation of defects in the gene mapping detoxification (38.5 % of all mutations and immunoregulation (22.5 %. Analysis of the cause-effect relationships in the system "factor - the number of mutations" revealed that candidate genes reflecting strontium exposure conditions (content of strontium in drinking water is 1.3 MAC, are genes: cytochrome P450, glutathione - transaminase (detoxification; dopamine (CNS, interleukin 17 and the major histocompatibility complex (immune system, methylene-tetra-hydro-folate-reductase (reproduction.

Biohazard Analysis of Select Biodefense Vaccine Candidates - Venezuelan Equine Encephalitis Virus Strain 3526 and Francisella Tularensis LVS

International Nuclear Information System (INIS)

Rao, V.

2007-01-01

Biohazard assessment of biodefense vaccine candidates forms the basis for a facility- and activity-specific risk assessment performed to determine the biosafety levels and general safety standards required for biological product development. As a part of our support to the US biodefense vaccine development program, we perform a systematic biohazard assessment of potential vaccine candidates with the primary objective to, (a) Identify and characterize hazard elements associated with the wild type and vaccine strains, (b) Provide biohazard information on the etiologic agent (vaccine candidate) to assess Phase 1 clinical trial facility sites, (c) Provide a baseline to conduct an agent and facility-specific risk assessment at clinical trial facilities interested in performing phase 1 clinical trial, (d) Provide comparative hazard profiles of the vaccine candidates wit MSDS for wild-type to identify and establish appropriate protective biosafety levels, and (e) Support determination of a hazard level to select personal protective equipment as required under the OSHA guidelines. This paper will describe the biohazard analysis of two vaccine candidates, Venezuelan Equine Encephalitis Virus Strain 3526 and Francisella tularensis LVS, a viral and bacterial agent, respectively. As part of the biohazard assessment we preformed a thorough review of published literature on medical pathology, epidemiology, pre-clinical investigational studies, and environmental data on the etiologic agent subtypes and the vaccine candidates. Using standard analytical procedures, the data were then analyzed relative to two intrinsic hazard parameters-health hazard and environmental hazard. Using a weight-of-evidence (WOE) approach, the potential hazards of etiologic agent wild subtypes and vaccine candidates were ranked under three main categories: Public Health Hazard, Environmental Hazard, and Overall Hazard. A WOE scoring system allows for both a determination of the intrinsic hazard of each

Biohazard Analysis of Select Biodefense Vaccine Candidates - Venezuelan Equine Encephalitis Virus Strain 3526 and Francisella Tularensis LVS

Energy Technology Data Exchange (ETDEWEB)

Rao, V [National Security Programs, Computer Science Corporation, Alexandria (United States)

2007-07-01

Biohazard assessment of biodefense vaccine candidates forms the basis for a facility- and activity-specific risk assessment performed to determine the biosafety levels and general safety standards required for biological product development. As a part of our support to the US biodefense vaccine development program, we perform a systematic biohazard assessment of potential vaccine candidates with the primary objective to, (a) Identify and characterize hazard elements associated with the wild type and vaccine strains, (b) Provide biohazard information on the etiologic agent (vaccine candidate) to assess Phase 1 clinical trial facility sites, (c) Provide a baseline to conduct an agent and facility-specific risk assessment at clinical trial facilities interested in performing phase 1 clinical trial, (d) Provide comparative hazard profiles of the vaccine candidates wit MSDS for wild-type to identify and establish appropriate protective biosafety levels, and (e) Support determination of a hazard level to select personal protective equipment as required under the OSHA guidelines. This paper will describe the biohazard analysis of two vaccine candidates, Venezuelan Equine Encephalitis Virus Strain 3526 and Francisella tularensis LVS, a viral and bacterial agent, respectively. As part of the biohazard assessment we preformed a thorough review of published literature on medical pathology, epidemiology, pre-clinical investigational studies, and environmental data on the etiologic agent subtypes and the vaccine candidates. Using standard analytical procedures, the data were then analyzed relative to two intrinsic hazard parameters-health hazard and environmental hazard. Using a weight-of-evidence (WOE) approach, the potential hazards of etiologic agent wild subtypes and vaccine candidates were ranked under three main categories: Public Health Hazard, Environmental Hazard, and Overall Hazard. A WOE scoring system allows for both a determination of the intrinsic hazard of each

The scientific argumentation profile of physics teacher candidate in Surabaya

Science.gov (United States)

Ain, T. N.; Wibowo, H. A. C.; Rohman, A.; Deta, U. A.

2018-03-01

The ability of scientific argumentation is an essential factor that must be mastered by physics teacher candidate as a requirement in explaining good and accurate scientific concepts. In the process of arguing, students develop explanations or persuade colleagues to support their hypotheses, express doubts, ask questions, relate alternative answers, and confirm what is unknown to develop the ability to provide rational and scientific explanations. The design of this research is descriptive qualitative with the subject of research is 20 undergraduate students of Physics Education Department in Surabaya. The research instrument consists of four casuistic questions related to the concept of kinematics. The argumentation pattern of physics teacher candidate is coded using Toulmin's argumentation pattern. The results show that the student’s ability in providing scientific argument is at the level of providing claims with the support of a weak warrant. The students are not able to provide excellent rebuttals. In each case given, the student can give a good claim statement in answering the questions. However, the concept used to support the claim is not correct. This case causes the warrant used to support the claim is weak. Students also do not analyse other facts that affect the system. Students have not reached a higher level because the understanding of physics is not deep enough.

Political attitudes bias the mental representation of a presidential candidate's face.

Science.gov (United States)

Young, Alison I; Ratner, Kyle G; Fazio, Russell H

2014-02-01

Using a technique known as reverse-correlation image classification, we demonstrated that the face of Mitt Romney as represented in people's minds varies as a function of their attitudes toward Mitt Romney. Our findings provide evidence that attitudes bias how people see something as concrete and well learned as the face of a political candidate during an election. Practically, our findings imply that citizens may not merely interpret political information about a candidate to fit their opinion, but also may construct a political world in which they literally see candidates differently.

Physics design of a 28 GHz electron heating system for the National Spherical Torus experiment upgrade

Energy Technology Data Exchange (ETDEWEB)

Taylor, G.; Bertelli, N.; Ellis, R. A.; Gerhardt, S. P.; Hosea, J. C.; Poli, F. [Princeton Plasma Physics Laboratory, Princeton University, Princeton, New Jersey 08543 (United States); Harvey, R. W. [CompX, Del Mar, California 92014 (United States); Raman, R. [University of Washington, Seattle, Washington 98195 (United States); Smirnov, A. P. [M.V. Lomonosov Moscow State University, Moscow (Russian Federation)

2014-02-12

A megawatt-level, 28 GHz electron heating system is being designed to support non-inductive (NI) plasma current (I{sub p}) start-up and local heating and current drive (CD) in H-mode discharges in the National Spherical Torus Experiment Upgrade (NSTX-U). The development of fully NI I{sub p} start-up and ramp-up is an important goal of the NSTXU research program. 28 GHz electron cyclotron (EC) heating is predicted to rapidly increase the central electron temperature (T{sub e}(0)) of low density NI plasmas generated by Coaxial Helicity Injection (CHI). The increased T{sub e}(0) will significantly reduce the I{sub p} decay rate of CHI plasmas, allowing the coupling of fast wave heating and neutral beam injection. Also 28 GHz electron Bernstein wave (EBW) heating and CD can be used during the I{sub p} flat top in NSTX-U discharges when the plasma is overdense. Ray tracing and Fokker-Planck numerical simulation codes have been used to model EC and EBW heating and CD in NSTX-U. This paper presents a pre-conceptual design for the 28 GHz heating system and some of the results from the numerical simulations.

A systematic review on the safety and efficacy of percutaneous edge-to-edge mitral valve repair with the MitraClip system for high surgical risk candidates

DEFF Research Database (Denmark)

Munkholm-Larsen, Stine; Wan, Benjamin; Tian, David H

2014-01-01

BACKGROUND: MitraClip implantation has emerged as a viable option in high surgical risk patients with severe mitral regurgitation (MR). We performed the present systematic review to assess the safety and efficacy of the MitraClip system for high surgical risk candidates with severe organic and....../or functional MR. METHODS: Six electronic databases were searched for original published studies from January 2000 to March 2013. Two reviewers independently appraised studies, using a standard form, and extracted data on methodology, quality criteria, and outcome measures. All data were extracted and tabulated...

Candidate genes in ocular dominance plasticity

NARCIS (Netherlands)

Rietman, M.L.; Sommeijer, J.-P.; Levelt, C.N.; Heimel, J.A.; Brussaard, A.B.; Borst, J.G.G.; Elgersma, Y.; Galjart, N.; van der Horst, G.T.; Pennartz, C.M.; Smit, A.B.; Spruijt, B.M.; Verhage, M.; de Zeeuw, C.I.

2012-01-01

Many studies have been devoted to the identification of genes involved in experience-dependent plasticity in the visual cortex. To discover new candidate genes, we have reexamined data from one such study on ocular dominance (OD) plasticity in recombinant inbred BXD mouse strains. We have correlated

PLANET HUNTERS. VIII. CHARACTERIZATION OF 41 LONG-PERIOD EXOPLANET CANDIDATES FROM KEPLER ARCHIVAL DATA

International Nuclear Information System (INIS)

Wang, Ji; Fischer, Debra A.; Picard, Alyssa; Schmitt, Joseph R.; Boyajian, Tabetha S.; Barclay, Thomas; Ma, Bo; Bowler, Brendan P.; Riddle, Reed; Jek, Kian J.; LaCourse, Daryll; Simister, Dean Joseph; Grégoire, Boscher; Babin, Sean P.; Poile, Trevor; Jacobs, Thomas Lee; Baranec, Christoph; Law, Nicholas M.; Lintott, Chris; Schawinski, Kevin

2015-01-01

The census of exoplanets is incomplete for orbital distances larger than 1 AU. Here, we present 41 long-period planet candidates in 38 systems identified by Planet Hunters based on Kepler archival data (Q0–Q17). Among them, 17 exhibit only one transit, 14 have two visible transits, and 10 have more than three visible transits. For planet candidates with only one visible transit, we estimate their orbital periods based on transit duration and host star properties. The majority of the planet candidates in this work (75%) have orbital periods that correspond to distances of 1–3 AU from their host stars. We conduct follow-up imaging and spectroscopic observations to validate and characterize planet host stars. In total, we obtain adaptive optics images for 33 stars to search for possible blending sources. Six stars have stellar companions within 4″. We obtain high-resolution spectra for 6 stars to determine their physical properties. Stellar properties for other stars are obtained from the NASA Exoplanet Archive and the Kepler Stellar Catalog by Huber et al. We validate 7 planet candidates that have planet confidence over 0.997 (3σ level). These validated planets include 3 single-transit planets (KIC-3558849b, KIC-5951458b, and KIC-8540376c), 3 planets with double transits (KIC-8540376b, KIC-9663113b, and KIC-10525077b), and 1 planet with four transits (KIC-5437945b). This work provides assessment regarding the existence of planets at wide separations and the associated false positive rate for transiting observation (17%–33%). More than half of the long-period planets with at least three transits in this paper exhibit transit timing variations up to 41 hr, which suggest additional components that dynamically interact with the transiting planet candidates. The nature of these components can be determined by follow-up radial velocity and transit observations

PLANET HUNTERS. VIII. CHARACTERIZATION OF 41 LONG-PERIOD EXOPLANET CANDIDATES FROM KEPLER ARCHIVAL DATA

Energy Technology Data Exchange (ETDEWEB)

Wang, Ji; Fischer, Debra A.; Picard, Alyssa; Schmitt, Joseph R.; Boyajian, Tabetha S. [Department of Astronomy, Yale University, New Haven, CT 06511 (United States); Barclay, Thomas [NASA Ames Research Center, M/S 244-30, Moffett Field, CA 94035 (United States); Ma, Bo [Department of Astronomy, University of Florida, 211 Bryant Space Science Center, Gainesville, FL 32611-2055 (United States); Bowler, Brendan P.; Riddle, Reed [California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91101 (United States); Jek, Kian J.; LaCourse, Daryll; Simister, Dean Joseph; Grégoire, Boscher; Babin, Sean P.; Poile, Trevor; Jacobs, Thomas Lee; Baranec, Christoph [Institute for Astronomy, University of Hawai‘i at Mānoa, Hilo, HI 96720-2700 (United States); Law, Nicholas M. [Department of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3255 (United States); Lintott, Chris [Oxford Astrophysics, Denys Wilkinson Building, Keble Road, Oxford OX1 3RH (United Kingdom); Schawinski, Kevin [Institute for Astronomy, Department of Physics, ETH Zurich, Wolfgang-Pauli-Strasse 27, CH-8093 Zurich (Switzerland); and others

2015-12-20

The census of exoplanets is incomplete for orbital distances larger than 1 AU. Here, we present 41 long-period planet candidates in 38 systems identified by Planet Hunters based on Kepler archival data (Q0–Q17). Among them, 17 exhibit only one transit, 14 have two visible transits, and 10 have more than three visible transits. For planet candidates with only one visible transit, we estimate their orbital periods based on transit duration and host star properties. The majority of the planet candidates in this work (75%) have orbital periods that correspond to distances of 1–3 AU from their host stars. We conduct follow-up imaging and spectroscopic observations to validate and characterize planet host stars. In total, we obtain adaptive optics images for 33 stars to search for possible blending sources. Six stars have stellar companions within 4″. We obtain high-resolution spectra for 6 stars to determine their physical properties. Stellar properties for other stars are obtained from the NASA Exoplanet Archive and the Kepler Stellar Catalog by Huber et al. We validate 7 planet candidates that have planet confidence over 0.997 (3σ level). These validated planets include 3 single-transit planets (KIC-3558849b, KIC-5951458b, and KIC-8540376c), 3 planets with double transits (KIC-8540376b, KIC-9663113b, and KIC-10525077b), and 1 planet with four transits (KIC-5437945b). This work provides assessment regarding the existence of planets at wide separations and the associated false positive rate for transiting observation (17%–33%). More than half of the long-period planets with at least three transits in this paper exhibit transit timing variations up to 41 hr, which suggest additional components that dynamically interact with the transiting planet candidates. The nature of these components can be determined by follow-up radial velocity and transit observations.

Functional analysis for complex systems of nuclear fusion plant

International Nuclear Information System (INIS)

Pinna, Tonio; Dongiovanni, Danilo Nicola; Iannone, Francesco

2016-01-01

Highlights: • Functional analysis for complex systems. • Functional Flow Block Diagrams (FFBD). • IDEFØ diagrams. • Petri Net algorithm - Abstract: In system engineering context, a functional analysis is the systematic process of identifying, describing and correlating the functions a system must perform in order to be successful at any foreseen life-cycle phase or operational state/mode. By focusing on what the system must do disregarding the implementation, the functional analysis supports an unbiased system requirement allocation analysis. The system function architecture is defined in terms of process, protection (interlock) or nuclear safety functions. Then, the system functions are analyzed from several points of view in order to highlight the various pieces of information defining the way the system is designed to accomplish its mission as defined in the system requirement documents. The process functional flow is identified and represented by Functional Flow Block Diagrams (FFBD) while the system function interfaces are identified and represented by IDEFØ diagrams. Function interfaces are defined as relationships across identified functions in terms of function input (from other functions or requirements), output (added value or outcome of the function), controls (from other functions or systems) and mechanisms necessary to fulfill the function. The function architecture is further detailed by considering for each function: a) the phase of application, b) the actions performed c) the controlled variable and control actions to be foreseen in the implementation of the functions, d) the system involved in the control action, e) the equipment involved in the function, f) the requirements allocated to the function. The methodology here presented are suggested for the designing of fusion facilities and reactors already from the first phases of the pre-conceptual design, as it is now for DEMO.

SARS CTL vaccine candidates; HLA supertype-, genome-wide scanning and biochemical validation

DEFF Research Database (Denmark)

Sylvester-Hvid, C; Nielsen, M; Lamberth, K

2004-01-01

. Exact knowledge of how the immune system handles protein antigens would allow for the identification of such linear sequences directly from genomic/proteomic sequence information (Lauemoller et al., Rev Immunogenet 2001: 2: 477-91). The latter was recently established when a causative coronavirus (SARS...... of the HLA supertypes and identified almost 100 potential vaccine candidates. These should be further validated in SARS survivors and used for vaccine formulation. We suggest that immunobioinformatics may become a fast and valuable tool in rational vaccine design....

SARS CTL vaccine candidates; HLA supertype-, genome-wide scanning and biochemical validation

DEFF Research Database (Denmark)

Sylvester-Hvid, C.; Nielsen, Morten; Lamberth, K.

2004-01-01

. Exact knowledge of how the immune system handles protein antigens would allow for the identification of such linear sequences directly, from genomic/proteomic sequence information (Lauemoller et al., Rev Immunogenet 2001: 2: 477-91). The latter was recently established when a causative coronavirus (SARS...... of the HLA supertypes and identified almost 100 potential vaccine candidates. These should be further validated in SARS survivors and used for vaccine formulation. We suggest that immunobioinformatics may become a fast and valuable tool in rational vaccine design....

ELECTIONS PENSION FUND CANDIDATE NR 2

CERN Multimedia

2001-01-01

ORGANISATION EUROPEENNE POUR LA RECHERCHE NUCLEAIRE CERN EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH CAISSE DE PENSIONS / PENSION FUND Caisse de Pensions - ELECTIONS - Pension Fund This candidature has been duly registered and is hereby presented in accordance with paragraph 6.h of the Regulations for Elections to the Governing Board of the Pension Fund. Candidate : Name : FRANDSEN First Name : Poul Kjaer  I have been member of the staff since 1974, and member of staff council for more than 12 years, and my main motivation has been to work for improving the social conditions of the CERN staff. A very important pillar of this is a sound and healthy pension fund. A capitalised scheme has been and still is the best choice for assuring the benefits for the CERN staff, present and future, this social system being part of the whole necessary to attract the best staff to the future High Energy Physics in Europe. However, even the hypothetic close down of the Organisation should allow the benefits to exi...

ELECTIONS PENSION FUND 2nd candidate

CERN Multimedia

2001-01-01

ORGANISATION EUROPEENNE POUR LA RECHERCHE NUCLEAIRE CERN EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH CAISSE DE PENSIONS / PENSION FUND Caisse de Pensions - ELECTIONS - Pension Fund This candidature has been duly registered and is hereby presented in accordance with paragraph 6.h of the Regulations for Elections to the Governing Board of the Pension Fund. Candidate : Name : FRANDSEN First Name : Poul Kjaer  I have been member of the staff since 1974, and member of staff council for more than 12 years, and my main motivation has been to work for improving the social conditions of the CERN staff. A very important pillar of this is a sound and healthy pension fund. A capitalised scheme has been and still is the best choice for assuring the benefits for the CERN staff, present and future, this social system being part of the whole necessary to attract the best staff to the future High Energy Physics in Europe. However, even the hypothetic close down of the Organisation should allow the benefits to exi...

Analysis of candidates for interacting galaxy clusters. I. A1204 and A2029/A2033

Science.gov (United States)

Gonzalez, Elizabeth Johana; de los Rios, Martín; Oio, Gabriel A.; Lang, Daniel Hernández; Tagliaferro, Tania Aguirre; Domínguez R., Mariano J.; Castellón, José Luis Nilo; Cuevas L., Héctor; Valotto, Carlos A.

2018-04-01

Context. Merging galaxy clusters allow for the study of different mass components, dark and baryonic, separately. Also, their occurrence enables to test the ΛCDM scenario, which can be used to put constraints on the self-interacting cross-section of the dark-matter particle. Aim. It is necessary to perform a homogeneous analysis of these systems. Hence, based on a recently presented sample of candidates for interacting galaxy clusters, we present the analysis of two of these cataloged systems. Methods: In this work, the first of a series devoted to characterizing galaxy clusters in merger processes, we perform a weak lensing analysis of clusters A1204 and A2029/A2033 to derive the total masses of each identified interacting structure together with a dynamical study based on a two-body model. We also describe the gas and the mass distributions in the field through a lensing and an X-ray analysis. This is the first of a series of works which will analyze these type of system in order to characterize them. Results: Neither merging cluster candidate shows evidence of having had a recent merger event. Nevertheless, there is dynamical evidence that these systems could be interacting or could interact in the future. Conclusions: It is necessary to include more constraints in order to improve the methodology of classifying merging galaxy clusters. Characterization of these clusters is important in order to properly understand the nature of these systems and their connection with dynamical studies.

A METHANE IMAGING SURVEY FOR T DWARF CANDIDATES IN ρ OPHIUCHI

International Nuclear Information System (INIS)

Haisch, Karl E.; Barsony, Mary; Tinney, Chris

2010-01-01

We report on the results of the first deep, wide-field, near-infrared methane imaging survey of the ρ Ophiuchi cloud core to search for T dwarfs. Among the 6587 objects detected, 22 were identified as T dwarf candidates. Brown dwarf models indicate that at the age and distance of the ρ Ophiuchi cloud, these T dwarf candidates have masses between 1 and 2 Jupiter masses. If confirmed as genuine T dwarfs, these objects would be the youngest, lowest mass, and lowest gravity free-floating objects ever directly observed. The existence of these candidates suggests that the initial mass function of the ρ Ophiuchi cloud extends well into the regime of planetary mass objects. A large fraction (59% ± 16%) of our T dwarf candidates appear to be surrounded by circumstellar disks, and thus represents the lowest mass objects yet found to harbor circumstellar disks.

IDENTIFICATION OF NEW GAMMA-RAY BLAZAR CANDIDATES WITH MULTIFREQUENCY ARCHIVAL OBSERVATIONS

Energy Technology Data Exchange (ETDEWEB)

Cowperthwaite, Philip S. [Department of Astronomy, University of Maryland, College Park, MD 20742-2421 (United States); Massaro, F. [SLAC National Laboratory and Kavli Institute for Particle Astrophysics and Cosmology, 2575 Sand Hill Road, Menlo Park, CA 94025 (United States); D' Abrusco, R.; Paggi, A.; Smith, Howard A. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Tosti, G., E-mail: pcowpert@umd.edu [Dipartimento di Fisica, Università Degli Studi di Perugia, I-06123 Perugia (Italy)

2013-11-01

Blazars are a highly variable, radio-loud subclass of active galactic nuclei. In order to better understand such objects we must be able to easily identify candidate blazars from the growing population of unidentified sources. Working toward this goal, we attempt to identify new gamma-ray blazar candidates from a sample of 102 previously unidentified sources. These sources are selected from The Astronomer's Telegram and the literature on the basis of non-periodic variability and multi-wavelength behavior. We then attempt to associate these objects to an IR counterpart in the Wide-field Infrared Survey Explorer all-sky survey. We are able to identify 16 candidate sources whose IR colors are consistent with those of the blazar population. Of those, 13 sources have IR colors indicative of being gamma-ray emitting blazar candidates. These sources all possess archival multi-wavelength observations that support their blazar-like nature.

An automated synthesis-purification-sample-management platform for the accelerated generation of pharmaceutical candidates.

Science.gov (United States)

Sutherland, J David; Tu, Noah P; Nemcek, Thomas A; Searle, Philip A; Hochlowski, Jill E; Djuric, Stevan W; Pan, Jeffrey Y

2014-04-01

A flexible and integrated flow-chemistry-synthesis-purification compound-generation and sample-management platform has been developed to accelerate the production of small-molecule organic-compound drug candidates in pharmaceutical research. Central to the integrated system is a Mitsubishi robot, which hands off samples throughout the process to the next station, including synthesis and purification, sample dispensing for purity and quantification analysis, dry-down, and aliquot generation.

ECONOMIC GROWTH IN SOUTH EASTERN EUROPE: AN INVESTIGATION FOR SIX EU CANDIDATE AND POTENTIAL CANDIDATE COUNTRIES

Directory of Open Access Journals (Sweden)

Ileana Tache

2017-08-01

Full Text Available The South Eastern European region (SEE has seen major beneficial transformation in the recent years. Romania and Bulgaria in 2007 and Croatia in 2013 became members of the European Union and registered significant economic growth rates. This paper investigates some important factors that influence economic growth in 6 EU candidate and potential candidate countries (Albania, Bosnia and Herzegovina, Kosovo, Former Yugoslav Republic of Macedonia, Montenegro and Serbia and offers to policy makers in those countries key insights for stimulating the economy. The paper proposes a dynamic growth model which will be developed using the Quasi-maximum likelihood (QML estimation. This model is suited for this type of analysis because of the small T sample and also to cope with missingness. The results indicate that nine out of the fourteen variables were statistically significant. The number of non-resident tourists, the number of passenger cars, the number of children in pre-primary and primary-education are positive factors for economic growth. In contrast, government debt, inflation, all energy imports, railway transportation and primary production of coal and lignite are hindering development.

Candidate sample acquisition systems for the Rosetta

International Nuclear Information System (INIS)

Magnani, P.G.; Gerli, C.; Colombina, G.; Vielmo, P.

1989-01-01

The Comet Nucleus Sample Return (CNSR) mission, one of the four cornerstones of the ESA scientific program, is one of the most complex space ventures within the next century, both from technological and deep space exploration point of view. In the Rosetta scenario the sample acquisition phase represents the most critical point for the global mission's success. The proposed paper illustrates the main results obtained in the context of the CNSR-SAS ongoing activity. The main areas covered are related to: (1) sample properties characterization (comet soil model, physical/chemical properties, reference material for testing); (2) concepts identification for coring, shovelling, harpooning and anchoring; (3) preferred concept (trade off among concepts, identification of the preferred configuration); and (4) proposed development activity for gaining the necessary confidence before finalizing the CNSR mission. Particular emphasis will be given to the robotic and flexibility aspects of the identified sample acquisition systems (SAS) configuration, intended as a means for the overall system performance enhancement

The nature of the giant exomoon candidate Kepler-1625 b-i

Science.gov (United States)

Heller, René

2018-02-01

The recent announcement of a Neptune-sized exomoon candidate around the transiting Jupiter-sized object Kepler-1625 b could indicate the presence of a hitherto unknown kind of gas giant moon, if confirmed. Three transits of Kepler-1625 b have been observed, allowing estimates of the radii of both objects. Mass estimates, however, have not been backed up by radial velocity measurements of the host star. Here we investigate possible mass regimes of the transiting system that could produce the observed signatures and study them in the context of moon formation in the solar system, i.e., via impacts, capture, or in-situ accretion. The radius of Kepler-1625 b suggests it could be anything from a gas giant planet somewhat more massive than Saturn (0.4 MJup) to a brown dwarf (BD; up to 75 MJup) or even a very-low-mass star (VLMS; MJup ≈ 0.11 M⊙). The proposed companion would certainly have a planetary mass. Possible extreme scenarios range from a highly inflated Earth-mass gas satellite to an atmosphere-free water-rock companion of about 180 M⊕. Furthermore, the planet-moon dynamics during the transits suggest a total system mass of 17.6-12.6+19.2 MJup. A Neptune-mass exomoon around a giant planet or low-mass BD would not be compatible with the common mass scaling relation of the solar system moons about gas giants. The case of a mini-Neptune around a high-mass BD or a VLMS, however, would be located in a similar region of the satellite-to-host mass ratio diagram as Proxima b, the TRAPPIST-1 system, and LHS 1140 b. The capture of a Neptune-mass object around a 10 MJup planet during a close binary encounter is possible in principle. The ejected object, however, would have had to be a super-Earth object, raising further questions of how such a system could have formed. In summary, this exomoon candidate is barely compatible with established moon formation theories. If it can be validated as orbiting a super-Jovian planet, then it would pose an exquisite riddle for

The Influence of Explicit Racial Cues on Candidate Evaluation

OpenAIRE

Green, Joshua Aaron

2013-01-01

Since Barack Obama's presidential campaign of 2008, media outlets have changed how race is covered and framed during political campaigns. In the so-called "post-racial" era of American politics when race is supposed to matter less, we are still very much attuned to stories that are framed by racial conflict. When the media wraps a "racial mode of interpretation" around a conflict between two candidates, there are potential electoral penalties involved for either a white or black candidate who...

Comparison of costs for alternative mixed low-level waste treatment systems

International Nuclear Information System (INIS)

Schwinkendorf, W.E.; Harvego, L.; Cooley, C.R.; Biagi, C.

1996-01-01

Total life cycle costs (TLCCs), including disposal costs, of thermal, nonthermal and enhanced nonthermal systems were evaluated to guide future research and development programs for the treatment of mixed low-level waste (MLLW) consisting of RCRA hazardous and low-level radioactive wastes. In these studies, nonthermal systems are defined as those systems that process waste at temperatures less than 350 C. Preconceptual designs and costs were developed for thirty systems with a capacity (2,927 lbs/hr) to treat the DOE MLLW stored inventor y(approximately 236 million pounds) in 20 years in a single, centralized facility. A limited comparison of the studies' results is presented in this paper. Sensitivity of treatment costs with respect to treatment capacity, number of treatment facilities, and system availability were also determined. The major cost element is operations and maintenance (O and M), which is 50 to 60% of the TLCC for both thermal and nonthermal systems. Energy costs constitute a small fraction (< 1%) of the TLCCs. Equipment cost is only 3 to 5% of the treatment cost. Evaluation of subsystem costs demonstrate that receiving and preparation is the highest cost subsystem at about 25 to 30% of the TLCC for both thermal and nonthermal systems. These studies found no cost incentives to use nonthermal or hybrid (combined nonthermal treatment with stabilization by vitrification) systems in place of thermal systems. However, there may be other incentives including fewer air emissions and less local objection to a treatment facility. Building multiple treatment facilities to treat the same total mass of waste as a single facility would increase the total treatment cost significantly, and improved system availability decreases unit treatment costs by 17% to 30%

Psychological aptitude evaluation of the special forces candidate.

Science.gov (United States)

Genoni, Luca; Jelmini, F; Lang, M; Muggli, F

2017-02-01

Changes in recruitment procedures reduced early dismissal rates from Swiss military basic recruitment schools; however, such improvements were not reflected in premature discharge rates from the special forces (SF) (Grenadier) recruitment school. A six-item questionnaire designed to identify recruits likely to be subject to premature dismissal on psychological or psychiatric grounds was developed and prospectively validated. The questionnaire was based on an analysis of medical and psychiatric/psychological records of 26 recruits dismissed from a SF recruitment school. Six items were identified that appeared to have prognostic value for early discharge. These six questions were submitted to the remaining applicants in the recruitment school by a suitably qualified psychologist or psychiatrist and effectively identified candidates who would be discharged early. Based on these results a 0-6 scale was developed and applied prospectively to subsequent Grenadier recruitment courses. Statistical analysis showed that 75% of candidates with the lowest scores would eventually complete the course and that no candidates with highest scores would subsequently complete the recruitment course. Prospective studies in subsequent recruitment courses candidates with high scores were classified as not qualified to enter the course, and those with intermediate scores were subject to additional in-depth interviews with a psychologist or psychiatrist to determine their suitability. In the following courses a correlation was established between the questionnaire score and week of discharge for those discharged. Application of this method during subsequent recruitment courses has reduced early dismissal from Swiss SF recruitment schools. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Medicaid Participation among Liver Transplant Candidates after the Affordable Care Act Medicaid Expansion.

Science.gov (United States)

Tumin, Dmitry; Beal, Eliza W; Mumtaz, Khalid; Hayes, Don; Tobias, Joseph D; Pawlik, Timothy M; Washburn, W Kenneth; Black, Sylvester M

2017-08-01

The 2014 Medicaid expansion in participating states increased insurance coverage among people with chronic health conditions, but its implications for access to surgical care remain unclear. We investigated how Medicaid expansion influenced the insurance status of candidates for liver transplantation (LT) and transplant center payor mix. Data on LT candidates aged 18 to 64 years, in 2012 to 2013 (pre-expansion) and 2014 to 2015 (post-expansion), were obtained from the United Network for Organ Sharing registry. Change between the 2 periods in the percent of LT candidates using Medicaid was compared between expansion and nonexpansion states. Multivariable logistic regression was used to determine how Medicaid expansion influenced individual LT candidates' likelihood of using Medicaid insurance. The study included 33,017 LT candidates, of whom 29,666 had complete data for multivariable analysis. Medicaid enrollment increased by 4% after Medicaid expansion in participating states. One-quarter of the transplant centers in these states experienced ≥10% increase in the proportion of LT candidates using Medicaid insurance. Multivariable analysis confirmed that Medicaid expansion was associated with increased odds of LT candidates using Medicaid insurance (odds ratio 1.49; 95% CI 1.34, 1.66; p Medicaid expansion states during the post-expansion period. Candidates for LT became more likely to use Medicaid after the 2014 Medicaid expansion policy came into effect. Enactment of this policy did not appear to increase access to LT or address socioeconomic and demographic disparities in access to the LT wait list. Copyright © 2017 American College of Surgeons. Published by Elsevier Inc. All rights reserved.

What Do Teacher Candidates Think about the Teaching Education? The Example of Social Studies Teacher Candidates

Science.gov (United States)

Tonga, Deniz

2016-01-01

In this research, it is aimed to reveal the opinions and observations of social studies teacher candidate about the courses they have taken during their 4-year university education. The focus group interview was used as the data collecting tool, and the content analyses were performed on the data obtained. The criterion sampling approach was used…

Promising new vaccine candidates against Campylobacter in broilers.

Directory of Open Access Journals (Sweden)

Marine Meunier

Full Text Available Campylobacter is the leading cause of human bacterial gastroenteritis in the European Union. Birds represent the main reservoir of the bacteria, and human campylobacteriosis mainly occurs after consuming and/or handling poultry meat. Reducing avian intestinal Campylobacter loads should impact the incidence of human diseases. At the primary production level, several measures have been identified to reach this goal, including vaccination of poultry. Despite many studies, however, no efficient vaccine is currently available. We have recently identified new vaccine candidates using the reverse vaccinology strategy. This study assessed the in vivo immune and protective potential of six newly-identified vaccine antigens. Among the candidates tested on Ross broiler chickens, four (YP_001000437.1, YP_001000562.1, YP_999817.1, and YP_999838.1 significantly reduced cecal Campylobacter loads by between 2 and 4.2 log10 CFU/g, with the concomitant development of a specific humoral immune response. In a second trial, cecal load reductions results were not statistically confirmed despite the induction of a strong immune response. These vaccine candidates need to be further investigated since they present promising features.

14 CFR 1214.1104 - Evaluation and ranking of highly qualified candidates.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Evaluation and ranking of highly qualified candidates. 1214.1104 Section 1214.1104 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION... ranking of highly qualified candidates. (a) A selection board consisting of discipline experts, and such...

Developing Expertise: Using Video to Hone Teacher Candidates' Classroom Observation Skills

Science.gov (United States)

Cuthrell, Kristen; Steadman, Sharilyn C.; Stapleton, Joy; Hodge, Elizabeth

2016-01-01

This article explores the impact of a video observation model developed for teacher candidates in an early experiences course. Video Grand Rounds (VGR) combines a structured observation protocol, videos, and directed debriefing to enhance teacher candidates' observations skills within nonstructured and field-based observations. A comparative…

Evaluation and selection of candidate high-level waste forms

International Nuclear Information System (INIS)

1982-03-01

Seven candidate waste forms being developed under the direction of the Department of Energy's National High-Level Waste (HLW) Technology Program, were evaluated as potential media for the immobilization and geologic disposal of high-level nuclear wastes. The evaluation combined preliminary waste form evaluations conducted at DOE defense waste-sites and independent laboratories, peer review assessments, a product performance evaluation, and a processability analysis. Based on the combined results of these four inputs, two of the seven forms, borosilicate glass and a titanate based ceramic, SYNROC, were selected as the reference and alternative forms for continued development and evaluation in the National HLW Program. Both the glass and ceramic forms are viable candidates for use at each of the DOE defense waste-sites; they are also potential candidates for immobilization of commercial reprocessing wastes. This report describes the waste form screening process, and discusses each of the four major inputs considered in the selection of the two forms

Framing the Socialisation Process of the DBA Candidate: What Can Universities Offer and What Should Candidates Bring?

Science.gov (United States)

Pervan, Simon; Blackman, Deborah; Sloan, Terry; Wallace, Michelle; Vocino, Andrea; Byrne, Cathy

2016-01-01

In Australia, the Doctorate of Business Administration (DBA) remains a popular program but considerable anguish persists within the university sector over just what it is offering students. In this article, we use the process of postgraduate socialisation to understand how candidates, supervisors and administrators navigate pathways to successful…

Boomers versus Millennials: Online Media Influence on Media Performance and Candidate Evaluations

Directory of Open Access Journals (Sweden)

Terri Towner

2016-09-01

Full Text Available Facebook posts, YouTube videos, tweets and wooing political bloggers have become standard practice in marketing political campaigns. Research has demonstrated the effect of new media on a host of politically-related behavior, including political participation, knowledge acquisition, group formation and self-efficacy. Yet, issues related to media trust, media performance and candidate evaluations have not been fully explored. In addition, much of the political marketing research looks exclusively at the Millennial age cohort, ignoring other age groups, particularly Baby Boomers. This case study addresses whether attention to traditional (i.e., television, hard-copy newspapers and radio and online media sources (i.e., political candidate websites, television network websites, online newspapers, Facebook, Twitter, YouTube, Tumblr and political blogs about the 2012 U.S. presidential campaign influences Millennials and Baby Boomers’ media trust and performance ratings, as well as candidate evaluations. Panel surveys were completed by both age cohorts, Millennials (n = 431 and Baby Boomers (n = 360, during the last two weeks of the presidential election. Findings indicate that traditional sources, specifically television, rather than online sources are significantly linked to media trust and performance ratings among both Boomers and Millennials. Attention to traditional media for campaign information predicts Boomers’ candidate evaluations, whereas Millennials’ candidate evaluations are influenced by online sources, such as Facebook and candidate websites.

Results of the Minnesota Multiphasic Personality Inventory-2 among gestational surrogacy candidates.

Science.gov (United States)

Klock, Susan C; Covington, Sharon N

2015-09-01

To obtain normative data on the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) personality test for gestational surrogate (GS) candidates. A retrospective study was undertaken through chart review of all GS candidates assessed at Shady Grove Fertility Center, Rockville, MD, USA, between June 2007 and December 2009. Participants completed the MMPI-2 test during screening. MMPI-2 scores, demographic information, and screening outcome were retrieved. Among 153 included candidates, 132 (86.3%) were accepted to be a GS, 6 (3.9%) were ruled out because of medical reasons, and 15 (9.8%) were ruled out because of psychological reasons. The mean scores on each of the MMPI-2 scales were within the normal range. A score of more than 65 (the clinical cutoff) was recorded on the L scale for 46 (30.1%) candidates, on the K scale for 61 (39.9%), and on the S scale for 84 (54.9%). Women who were ruled out for psychological reasons had significantly higher mean scores on the validity scales F and L, and on clinical scale 8 than did women who were accepted (P<0.05 for all). Most GS candidates are well adjusted and free of psychopathology, but candidates tend to present themselves in an overly positive way. Copyright © 2015 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

Research on Take an Examination of Oneself Potential Candidates Intend Empirical

Science.gov (United States)

Bo, Zhou Lin; Dong, Chen

2012-01-01

Through the metrological analysis to Sichuan Province of potential candidates in willingness to take the self-study exam, we find the potential candidates attendance of self-study exam mainly determined by the marital status, family supporting degree, mathematics course, English courses, and the willingness to improve academic degree. Knowing…

Assessment of potential solder candidates for high temperature applications

DEFF Research Database (Denmark)

pressure to eliminate lead containing materials despite the fact that materials for high Pb containing alloys are currently not affected by any legislations. A tentative assessment was carried out to determine the potential solder candidates for high temperature applications based on the solidification...... criterion, phases predicted in the bulk solder and the thermodynamic stability of chlorides. These promising solder candidates were precisely produced using the hot stage microscope and its respective anodic and cathodic polarization curves were investigated using a micro-electrochemical set up...

B cell repertoires in HLA-sensitized kidney transplant candidates undergoing desensitization therapy.

Science.gov (United States)

Beausang, John F; Fan, H Christina; Sit, Rene; Hutchins, Maria U; Jirage, Kshama; Curtis, Rachael; Hutchins, Edward; Quake, Stephen R; Yabu, Julie M

2017-01-13

Kidney transplantation is the most effective treatment for end-stage renal disease. Sensitization refers to pre-existing antibodies against human leukocyte antigen (HLA) protein and remains a major barrier to successful transplantation. Despite implementation of desensitization strategies, many candidates fail to respond. Our objective was to determine whether measuring B cell repertoires could differentiate candidates that respond to desensitization therapy. We developed an assay based on high-throughput DNA sequencing of the variable domain of the heavy chain of immunoglobulin genes to measure changes in B cell repertoires in 19 highly HLA-sensitized kidney transplant candidates undergoing desensitization and 7 controls with low to moderate HLA sensitization levels. Responders to desensitization had a decrease of 5% points or greater in cumulated calculated panel reactive antibody (cPRA) levels, and non-responders had no decrease in cPRA. Dominant B cell clones were not observed in highly sensitized candidates, suggesting that the B cells responsible for sensitization are either not present in peripheral blood or present at comparable levels to other circulating B cells. Candidates that responded to desensitization therapy had pre-treatment repertoires composed of a larger fraction of class-switched (IgG and IgA) isotypes compared to non-responding candidates. After B cell depleting therapy, the proportion of switched isotypes increased and the mutation frequencies of the remaining non-switched isotypes (IgM and IgD) increased in both responders and non-responders, perhaps representing a shift in the repertoire towards memory B cells or plasmablasts. Conversely, after transplantation, non-switched isotypes with fewer mutations increased, suggesting a shift in the repertoire towards naïve B cells. Relative abundance of different B cell isotypes is strongly perturbed by desensitization therapy and transplantation, potentially reflecting changes in the relative

A Catalog Sample of Low-mass Galaxies Observed in X-Rays with Central Candidate Black Holes

Energy Technology Data Exchange (ETDEWEB)

Nucita, A. A.; Manni, L.; Paolis, F. De; Giordano, M.; Ingrosso, G., E-mail: nucita@le.infn.it [Department of Mathematics and Physics “E. De Giorgi”, University of Salento, Via per Arnesano, CP 193, I-73100, Lecce (Italy)

2017-03-01

We present a sample of X-ray-selected candidate black holes in 51 low-mass galaxies with z ≤ 0.055 and masses up to 10{sup 10} M {sub ⊙} obtained by cross-correlating the NASA-SLOAN Atlas with the 3XMM catalog. We have also searched in the available catalogs for radio counterparts of the black hole candidates and find that 19 of the previously selected sources also have a radio counterpart. Our results show that about 37% of the galaxies of our sample host an X-ray source (associated with a radio counterpart) spatially coincident with the galaxy center, in agreement with other recent works. For these nuclear sources, the X-ray/radio fundamental plane relation allows one to estimate the mass of the (central) candidate black holes, which are in the range of 10{sup 4}–2 × 10{sup 8} M {sub ⊙} (with a median value of ≃3 × 10{sup 7} M {sub ⊙} and eight candidates having masses below 10{sup 7} M {sub ⊙}). This result, while suggesting that X-ray emitting black holes in low-mass galaxies may have had a key role in the evolution of such systems, makes it even more urgent to explain how such massive objects formed in galaxies. Of course, dedicated follow-up observations both in the X-ray and radio bands, as well as in the optical, are necessary in order to confirm our results.

Characterization of nanoparticles as candidate reference materials

International Nuclear Information System (INIS)

Martins Ferreira, E.H.; Robertis, E. de; Landi, S.M.; Gouvea, C.P.; Archanjo, B.S.; Almeida, C.A.; Araujo, J.R. de; Kuznetsov, O.; Achete, C.A.

2013-01-01

We report the characterization of three different nanoparticles (silica, silver and multi-walled carbon nanotubes) as candidate reference material. We focus our analysis on the size distribution of those particles as measured by different microscopy techniques. (author)

Identifying the Relationship of Teacher Candidates' Humor Styles with Anxiety and Self-Compassion Levels

Science.gov (United States)

Aydin, Aydan

2015-01-01

Problem Statement: Teacher candidates who will soon be responsible for educating the future generations should possess certain characteristics. Specific teacher candidates should have specific characteristics taken into consideration: pre-school and primary teacher candidates should be seen as role models by younger students; psychological…

Loss-of-coolant accident analyses of the Advanced Neutron Source Reactor

International Nuclear Information System (INIS)

Chen, N.C.J.; Yoder, G.L.; Wendel, M.W.

1991-01-01

Currently in the conceptual design stage, the Advanced Neutron Source Reactor (ANSR) will operate at a high heat flux, a high mass flux, an a high degree of coolant subcooling. Loss-of-coolant accident (LOCA) analyses using RELAP5 have been performed as part of an early evaluation of ANSR safety issues. This paper discusses the RELAP5 ANSR conceptual design system model and preliminary LOCA simulation results. Some previous studies were conducted for the preconceptual design. 12 refs., 7 figs

THE PERCEPTION OF THE CANDIDATES FOR MUSIC TEACHER ON MUSICAL AESTHETICS

Directory of Open Access Journals (Sweden)

Ulku Sevim SEN

2014-08-01

Full Text Available The basic aim of this study is to reveal the perception of the candidates for music teacher on musical aesthetics. In the light of this aim, the research question the study aims to answer: how is the perception of the candidates for music teacher on musical aesthetics? The participants in this research consist of overall eighty three freshman, sophomore, junior and senior students studying in the Department of Music Teaching, Ataturk Faculty of Fine Arts during spring term. The participants as the candidates for teacher involve forty nine women and thirty four men. The study is descriptive survey model of qualitative research.

Understanding and Affecting Science Teacher Candidates' Scientific Reasoning in Introductory Astrophysics

Science.gov (United States)

Steinberg, Richard; Cormier, Sebastien

2013-01-01

This study reports on a content course for science immersion teacher candidates that emphasized authentic practice of science and thinking scientifically in the context of introductory astrophysics. We explore how 122 science teacher candidates spanning three cohorts did and did not reason scientifically and how this evolved in our program. Our…

Upper gastrointestinal alterations in kidney transplant candidates.

Science.gov (United States)

Homse Netto, João Pedro; Pinheiro, João Pedro Sant'Anna; Ferrari, Mariana Lopes; Soares, Mirella Tizziani; Silveira, Rogério Augusto Gomes; Maioli, Mariana Espiga; Delfino, Vinicius Daher Alvares

2018-05-14

The incidence of gastrointestinal disorders among patients with chronic kidney disease (CKD) is high, despite the lack of a good correlation between endoscopic findings and symptoms. Many services thus perform upper gastrointestinal (UGI) endoscopy on kidney transplant candidates. This study aims to describe the alterations seen on the upper endoscopies of 96 kidney-transplant candidates seen from 2014 to 2015. Ninety-six CKD patients underwent upper endoscopic examination as part of the preparation to receive kidney grafts. The data collected from the patients' medical records were charted on Microsoft Office Excel 2016 and presented descriptively. Mean values, medians, interquartile ranges and 95% confidence intervals of the clinic and epidemiological variables were calculated. Possible associations between endoscopic findings and infection by H. pylori were studied. Males accounted for 54.17% of the 96 patients included in the study. Median age and time on dialysis were 50 years and 50 months, respectively. The most frequent upper endoscopy finding was enanthematous pangastritis (57.30%), followed by erosive esophagitis (30.20%). Gastric intestinal metaplasia and peptic ulcer were found in 8.33% and 7.30% of the patients, respectively. H. pylori tests were positive in 49 patients, and H. pylori infection was correlated only with non-erosive esophagitis (P = 0.046). Abnormal upper endoscopy findings were detected in all studied patients. This study suggested that upper endoscopy is a valid procedure for kidney transplant candidates. However, prospective studies are needed to shed more light on this matter.

Updated candidate list for engineered barrier materials

International Nuclear Information System (INIS)

McCright, R.D.

1995-10-01

This report describes candidate materials to be evaluated over the next several years during advanced design phases for the waste package to be used for the underground disposal of high-level radioactive wastes at the Yucca Mountain facility

Surface display of Clonorchis sinensis enolase on Bacillus subtilis spores potentializes an oral vaccine candidate.

Science.gov (United States)

Wang, Xiaoyun; Chen, Wenjun; Tian, Yanli; Mao, Qiang; Lv, Xiaoli; Shang, Mei; Li, Xuerong; Yu, Xinbing; Huang, Yan

2014-03-10

Clonorchis sinensis (C. sinensis) infections remain the common public health problem in freshwater fish consumption areas. New effective prevention strategies are still the urgent challenges to control this kind of foodborne infectious disease. The biochemical importance and biological relevance render C. sinensis enolase (Csenolase) as a potential vaccine candidate. In the present study, we constructed Escherichia coli/Bacillus subtilis shuttle genetic engineering system and investigated the potential of Csenolase as an oral vaccine candidate for C. sinensis prevention in different immunization routes. Our results showed that, compared with control groups, both recombinant Csenolase protein and nucleic acid could induce a mixed IgG1/IgG2a immune response when administrated subcutaneously (Psinensis infection. Csenolase derived oral vaccine conferred worm reduction rate and egg reduction rate at 60.07% (Psinensis prevention. Copyright © 2014 Elsevier Ltd. All rights reserved.

Assessing pharmacologic and nonpharmacologic risks in candidates for kidney transplantation.

Science.gov (United States)

Maldonado, Angela Q; Tichy, Eric M; Rogers, Christin C; Campara, Maya; Ensor, Christopher; Doligalski, Christina T; Gabardi, Steven; Descourouez, Jillian L; Doyle, Ian C; Trofe-Clark, Jennifer

2015-05-15

Pharmacotherapy concerns and other factors with a bearing on patient selection for kidney transplantation are discussed. The process of selecting appropriate candidates for kidney transplantation involves multidisciplinary assessment to evaluate a patient's mental, social, physical, financial, and medical readiness for successful surgery and good posttransplantation outcomes. Transplantation pharmacists can play important roles in the recognition and stratification of pharmacologic and nonpharmacologic risks in prospective kidney transplant recipients and the identification of issues that require a mitigation strategy. Key pharmacotherapy-related issues and considerations during the risk assessment process include (1) anticoagulation concerns, (2) cytochrome P-450 isoenzyme-mediated drug interactions, (3) mental health-related medication use, (4) chronic pain-related medication use, (5) medication allergies, (6) use of hormonal contraception and replacement therapy, (7) prior or current use of immunosuppressants, (8) issues with drug absorption, (9) alcohol use, (10) tobacco use, (11) active use of illicit substances, and (12) use of herbal supplements. Important areas of nonpharmacologic risk include vaccine delivery, infection prophylaxis and treatment, and socially related factors such as nonadherent behavior, communication barriers, and financial, insurance, or transportation challenges that can compromise posttransplantation outcomes. Consensus opinions of practitioners in transplantation pharmacy regarding the pharmacologic and nonpharmacologic factors that should be considered in assessing candidates for kidney transplantation are presented. Copyright © 2015 by the American Society of Health-System Pharmacists, Inc. All rights reserved.

Hydrogen permeation through Flinabe fluoride molten salts for blanket candidates

Energy Technology Data Exchange (ETDEWEB)

Nishiumi, Ryosuke, E-mail: r.nishiumi@aees.kyushu-u.ac.jp; Fukada, Satoshi; Nakamura, Akira; Katayama, Kazunari

2016-11-01

Highlights: • H{sub 2} diffusivity, solubility and permeability in Flinabe as T breeder are determined. • Effects in composition differences among Flibe, Fnabe and Flinabe are compared. • Changes of pressure dependence of Flinabe permeation rate are clarified. - Abstract: Fluoride molten salt Flibe (2LiF + BeF{sub 2}) is a promising candidate for the liquid blanket of a nuclear fusion reactor, because of its large advantages of tritium breeding ratio and heat-transfer fluid. Since its melting point is higher than other liquid candidates, another new fluoride molten salt Flinabe (LiF + NaF + BeF{sub 2}) is recently focused on because of its lower melting point while holding proper breeding properties. In this experiment, hydrogen permeation behavior through the three molten salts of Flibe (2LiF + BeF{sub 2}), Fnabe (NaF + BeF{sub 2}) and Flinabe are investigated in order to clarify the effects of their compositions on hydrogen transfer properties. After making up any of the three molten salts and purifying it using HF, hydrogen permeability, diffusivity and solubility of the molten salts are determined experimentally by using a system composed of tertiary cylindrical tubes. Close agreement is obtained between experimental data and analytical solutions. H{sub 2} permeability, diffusivity and solubility are correlated as a function of temperature and are compared among the three molten salts.

DUAL SUPERMASSIVE BLACK HOLE CANDIDATES IN THE AGN AND GALAXY EVOLUTION SURVEY

International Nuclear Information System (INIS)

Comerford, Julia M.; Schluns, Kyle; Greene, Jenny E.; Cool, Richard J.

2013-01-01

Dual supermassive black holes (SMBHs) with kiloparsec-scale separations in merger-remnant galaxies are informative tracers of galaxy evolution, but the avenue for identifying them in large numbers for such studies is not yet clear. One promising approach is to target spectroscopic signatures of systems where both SMBHs are fueled as dual active galactic nuclei (AGNs), or where one SMBH is fueled as an offset AGN. Dual AGNs may produce double-peaked narrow AGN emission lines, while offset AGNs may produce single-peaked narrow AGN emission lines with line-of-sight velocity offsets relative to the host galaxy. We search for such dual and offset systems among 173 Type 2 AGNs at z +3.6 -1.9 % to 18 +5 -5 %). This may be associated with the rise in the galaxy merger fraction over the same cosmic time. As further evidence for a link with galaxy mergers, the AGES offset and dual AGN candidates are tentatively ∼3 times more likely than the overall AGN population to reside in a host galaxy that has a companion galaxy (from 16/173 to 2/7, or 9 +3 -2 % to 29 -19 +26 %). Follow-up observations of the seven offset and dual AGN candidates in AGES will definitively distinguish velocity offsets produced by dual SMBHs from those produced by narrow-line region kinematics, and will help sharpen our observational approach to detecting dual SMBHs

Candidate genes for cross-resistance against DNA-damaging drugs

DEFF Research Database (Denmark)

Wittig, Rainer; Nessling, Michelle; Will, Rainer D

2002-01-01

Drug resistance of tumor cells leads to major drawbacks in the treatment of cancer. To identify candidate genes for drug resistance, we compared the expression patterns of the drug-sensitive human malignant melanoma cell line MeWo and three derived sublines with acquired resistance to the DNA...... as several apoptosis-related genes, in particular STK17A and CRYAB. As MPP1 and CRYAB are also among the 14 genes differentially expressed in all three of the drug-resistant sublines, they represent the strongest candidates for resistance against DNA-damaging drugs....

Advanced Vaccine Candidates for Lassa Fever

Directory of Open Access Journals (Sweden)

Igor S. Lukashevich

2012-10-01

Full Text Available Lassa virus (LASV is the most prominent human pathogen of the Arenaviridae. The virus is transmitted to humans by a rodent reservoir, Mastomys natalensis, and is capable of causing lethal Lassa Fever (LF. LASV has the highest human impact of any of the viral hemorrhagic fevers (with the exception of Dengue Fever with an estimated several hundred thousand infections annually, resulting in thousands of deaths in Western Africa. The sizeable disease burden, numerous imported cases of LF in non-endemic countries, and the possibility that LASV can be used as an agent of biological warfare make a strong case for vaccine development. Presently there is no licensed vaccine against LF or approved treatment. Recently, several promising vaccine candidates have been developed which can potentially target different groups at risk. The purpose of this manuscript is to review the LASV pathogenesis and immune mechanisms involved in protection. The current status of pre-clinical development of the advanced vaccine candidates that have been tested in non-human primates will be discussed. Major scientific, manufacturing, and regulatory challenges will also be considered.

275 Candidates and 149 Validated Planets Orbiting Bright Stars in K2 Campaigns 0–10

DEFF Research Database (Denmark)

Mayo, Andrew W.; Vanderburg, Andrew; Latham, David W.

2018-01-01

Since 2014, NASA’s K2 mission has observed large portions of the ecliptic plane in search of transiting planets and has detected hundreds of planet candidates. With observations planned until at least early 2018, K2 will continue to identify more planet candidates. We present here 275 planet...... candidates observed during Campaigns 0–10 of the K2 mission that are orbiting stars brighter than 13 mag (in Kepler band) and for which we have obtained high-resolution spectra ( R = 44,000). These candidates are analyzed using the vespa package in order to calculate their false-positive probabilities (FPP......). We find that 149 candidates are validated with an FPP lower than 0.1%, 39 of which were previously only candidates and 56 of which were previously undetected. The processes of data reduction, candidate identification, and statistical validation are described, and the demographics of the candidates...

Examining Technology and Teaching Efficacy of Preservice Teacher Candidates: A Deliberate Course Design Model

Science.gov (United States)

Willis, Jana M.

2015-01-01

Training programs that improve technology self-efficacy of teacher candidates will better prepare candidates to overcome technology challenges with greater levels of confidence. The purpose of this study was to examine self-efficacy levels of preservice teacher candidates who participated in scaffolded technology training designed to establish and…

Review of Y/OWI/TM-36: repository design performance in salt, granite, shale or basalt

International Nuclear Information System (INIS)

Talbot, R.; Nair, O.B.

1979-09-01

As part of the ongoing work by the Lawrence Livermore Laboratory to evaluate repository design performance, this memorandum presents a review of the preconceptual repository design described in Y/OWI/TM-36, Technical Support for GEIS: Radioactive Waste Isolation in Geologic Formations, April 1978. The purpose of this review is: to assess the adequacy of the design procedures and assumptions; to identify inappropriate or unsubstantiated design issues; to identify areas where additional numerical analyses may be required; and to develop data for inclusion in a reference repository design. The preconceptual repository design is presented in the form of 23 volumes of data base, analyses, and design layouts for four rock types: bedded salt, shale, granite and basalt. This memorandum reviews all four repository designs

Status of experimental data for the VHTR core design

Energy Technology Data Exchange (ETDEWEB)

Park, Won Seok; Chang, Jong Hwa; Park, Chang Kue

2004-05-01

The VHTR (Very High Temperature Reactor) is being emerged as a next generation nuclear reactor to demonstrate emission-free nuclear-assisted electricity and hydrogen production. The VHTR could be either a prismatic or pebble type helium cooled, graphite moderated reactor. The final decision will be made after the completion of the pre-conceptual design for each type. For the pre-conceptual design for both types, computational tools are being developed. Experimental data are required to validate the tools to be developed. Many experiments on the HTGR (High Temperature Gas-cooled Reactor) cores have been performed to confirm the design data and to validate the design tools. The applicability and availability of the existing experimental data have been investigated for the VHTR core design in this report.

Candidate genes and molecular markers associated with heat tolerance in colonial Bentgrass.

Science.gov (United States)

Jespersen, David; Belanger, Faith C; Huang, Bingru

2017-01-01

Elevated temperature is a major abiotic stress limiting the growth of cool-season grasses during the summer months. The objectives of this study were to determine the genetic variation in the expression patterns of selected genes involved in several major metabolic pathways regulating heat tolerance for two genotypes contrasting in heat tolerance to confirm their status as potential candidate genes, and to identify PCR-based markers associated with candidate genes related to heat tolerance in a colonial (Agrostis capillaris L.) x creeping bentgrass (Agrostis stolonifera L.) hybrid backcross population. Plants were subjected to heat stress in controlled-environmental growth chambers for phenotypic evaluation and determination of genetic variation in candidate gene expression. Molecular markers were developed for genes involved in protein degradation (cysteine protease), antioxidant defense (catalase and glutathione-S-transferase), energy metabolism (glyceraldehyde-3-phosphate dehydrogenase), cell expansion (expansin), and stress protection (heat shock proteins HSP26, HSP70, and HSP101). Kruskal-Wallis analysis, a commonly used non-parametric test used to compare population individuals with or without the gene marker, found the physiological traits of chlorophyll content, electrolyte leakage, normalized difference vegetative index, and turf quality were associated with all candidate gene markers with the exception of HSP101. Differential gene expression was frequently found for the tested candidate genes. The development of candidate gene markers for important heat tolerance genes may allow for the development of new cultivars with increased abiotic stress tolerance using marker-assisted selection.

Candidate genes and molecular markers associated with heat tolerance in colonial Bentgrass.

Directory of Open Access Journals (Sweden)

David Jespersen

Full Text Available Elevated temperature is a major abiotic stress limiting the growth of cool-season grasses during the summer months. The objectives of this study were to determine the genetic variation in the expression patterns of selected genes involved in several major metabolic pathways regulating heat tolerance for two genotypes contrasting in heat tolerance to confirm their status as potential candidate genes, and to identify PCR-based markers associated with candidate genes related to heat tolerance in a colonial (Agrostis capillaris L. x creeping bentgrass (Agrostis stolonifera L. hybrid backcross population. Plants were subjected to heat stress in controlled-environmental growth chambers for phenotypic evaluation and determination of genetic variation in candidate gene expression. Molecular markers were developed for genes involved in protein degradation (cysteine protease, antioxidant defense (catalase and glutathione-S-transferase, energy metabolism (glyceraldehyde-3-phosphate dehydrogenase, cell expansion (expansin, and stress protection (heat shock proteins HSP26, HSP70, and HSP101. Kruskal-Wallis analysis, a commonly used non-parametric test used to compare population individuals with or without the gene marker, found the physiological traits of chlorophyll content, electrolyte leakage, normalized difference vegetative index, and turf quality were associated with all candidate gene markers with the exception of HSP101. Differential gene expression was frequently found for the tested candidate genes. The development of candidate gene markers for important heat tolerance genes may allow for the development of new cultivars with increased abiotic stress tolerance using marker-assisted selection.

Maximizing the ExoEarth candidate yield from a future direct imaging mission

International Nuclear Information System (INIS)

Stark, Christopher C.; Roberge, Aki; Mandell, Avi; Robinson, Tyler D.

2014-01-01

ExoEarth yield is a critical science metric for future exoplanet imaging missions. Here we estimate exoEarth candidate yield using single visit completeness for a variety of mission design and astrophysical parameters. We review the methods used in previous yield calculations and show that the method choice can significantly impact yield estimates as well as how the yield responds to mission parameters. We introduce a method, called Altruistic Yield Optimization, that optimizes the target list and exposure times to maximize mission yield, adapts maximally to changes in mission parameters, and increases exoEarth candidate yield by up to 100% compared to previous methods. We use Altruistic Yield Optimization to estimate exoEarth candidate yield for a large suite of mission and astrophysical parameters using single visit completeness. We find that exoEarth candidate yield is most sensitive to telescope diameter, followed by coronagraph inner working angle, followed by coronagraph contrast, and finally coronagraph contrast noise floor. We find a surprisingly weak dependence of exoEarth candidate yield on exozodi level. Additionally, we provide a quantitative approach to defining a yield goal for future exoEarth-imaging missions.

Systematic Search for Rings around Kepler Planet Candidates: Constraints on Ring Size and Occurrence Rate

Science.gov (United States)

Aizawa, Masataka; Masuda, Kento; Kawahara, Hajime; Suto, Yasushi

2018-05-01

We perform a systematic search for rings around 168 Kepler planet candidates with sufficient signal-to-noise ratios that are selected from all of the short-cadence data. We fit ringed and ringless models to their light curves and compare the fitting results to search for the signatures of planetary rings. First, we identify 29 tentative systems, for which the ringed models exhibit statistically significant improvement over the ringless models. The light curves of those systems are individually examined, but we are not able to identify any candidate that indicates evidence for rings. In turn, we find several mechanisms of false positives that would produce ringlike signals, and the null detection enables us to place upper limits on the size of the rings. Furthermore, assuming the tidal alignment between axes of the planetary rings and orbits, we conclude that the occurrence rate of rings larger than twice the planetary radius is less than 15%. Even though the majority of our targets are short-period planets, our null detection provides statistical and quantitative constraints on largely uncertain theoretical models of the origin, formation, and evolution of planetary rings.

Candidate eco-friendly gas mixtures for MPGDs

Science.gov (United States)

Benussi, L.; Bianco, S.; Saviano, G.; Muhammad, S.; Piccolo, D.; Ferrini, M.; Parvis, M.; Grassini, S.; Colafranceschi, S.; Kjølbro, J.; Sharma, A.; Yang, D.; Chen, G.; Ban, Y.; Li, Q.

2018-02-01

Modern gas detectors for detection of particles require F-based gases for optimal performance. Recent regulations demand the use of environmentally unfriendly F-based gases to be limited or banned. This review studies properties of potential eco-friendly gas candidate replacements.

Certification of biological candidates reference materials by neutron activation analysis

Science.gov (United States)

Kabanov, Denis V.; Nesterova, Yulia V.; Merkulov, Viktor G.

2018-03-01

The paper gives the results of interlaboratory certification of new biological candidate reference materials by neutron activation analysis recommended by the Institute of Nuclear Chemistry and Technology (Warsaw, Poland). The correctness and accuracy of the applied method was statistically estimated for the determination of trace elements in candidate reference materials. The procedure of irradiation in the reactor thermal fuel assembly without formation of fast neutrons was carried out. It excluded formation of interfering isotopes leading to false results. The concentration of more than 20 elements (e.g., Ba, Br, Ca, Co, Ce, Cr, Cs, Eu, Fe, Hf, La, Lu, Rb, Sb, Sc, Ta, Th, Tb, Yb, U, Zn) in candidate references of tobacco leaves and bottom sediment compared to certified reference materials were determined. It was shown that the average error of the applied method did not exceed 10%.

How to Evaluate Integrated Library Automation Systems.

Science.gov (United States)

Powell, James R.; Slach, June E.

1985-01-01

This paper describes methodology used in compiling a list of candidate integrated library automation systems at a corporate technical library. Priorities for automation, identification of candidate systems, the filtering process, information for suppliers, software and hardware considerations, on-site evaluations, and final system selection are…

Search for Binary Black Hole Candidates from the VLBI Images of ...

Indian Academy of Sciences (India)

2016-01-27

Jan 27, 2016 ... We have searched the core-jet pairs in the VLBI scales (< 1 kpc), from several VLBI catalogues, and found out 5 possible Binary Black Hole (BBH) candidates. We present here the search results and analyse the candidates preliminarily. We plan to study with multi-band VLBI observation. We also plan to ...

Effects of Lesson Study on Science Teacher Candidates' Teaching Efficacies

Science.gov (United States)

Pektas, Murat

2014-01-01

The aim of this study was to investigate the effects of the lesson study process on science teacher candidates' teaching in terms of lesson plan content, pedagogy and classroom management based on expert, peer and self-evaluations. The participants of this case study consisted of 16 teacher candidates in elementary science education in their…

Campaigning on the Internet: 2008 Presidential General Election Candidate Webpage

OpenAIRE

William L. Benoit; Mark Glant; Leslie Rill

2016-01-01

The Internet is becoming an increasingly important component of political campaigns. This study employed content analysis to apply Functional Theory and Issue Ownership Theory to Obama’s and McCain’s presidential candidate webpages in the 2008 campaign. Acclaims (92%) were more common than attacks (98%); defenses did not occur in this sample. Policy (82%) was addressed more than character (18%). When discussing policy, these candidates addressed future plans most frequently, followed by gener...

Defining the Sequence Elements and Candidate Genes for the Coloboma Mutation.

Directory of Open Access Journals (Sweden)

Elizabeth A. Robb

Full Text Available The chicken coloboma mutation exhibits features similar to human congenital developmental malformations such as ocular coloboma, cleft-palate, dwarfism, and polydactyly. The coloboma-associated region and encoded genes were investigated using advanced genomic, genetic, and gene expression technologies. Initially, the mutation was linked to a 990 kb region encoding 11 genes; the application of the genetic and genomic tools led to a reduction of the linked region to 176 kb and the elimination of 7 genes. Furthermore, bioinformatics analyses of capture array-next generation sequence data identified genetic elements including SNPs, insertions, deletions, gaps, chromosomal rearrangements, and miRNA binding sites within the introgressed causative region relative to the reference genome sequence. Coloboma-specific variants within exons, UTRs, and splice sites were studied for their contribution to the mutant phenotype. Our compiled results suggest three genes for future studies. The three candidate genes, SLC30A5 (a zinc transporter, CENPH (a centromere protein, and CDK7 (a cyclin-dependent kinase, are differentially expressed (compared to normal embryos at stages and in tissues affected by the coloboma mutation. Of these genes, two (SLC30A5 and CENPH are considered high-priority candidate based upon studies in other vertebrate model systems.

Multiple candidate effectors from the oomycete pathogen Hyaloperonospora arabidopsidis suppress host plant immunity.

Directory of Open Access Journals (Sweden)

Georgina Fabro

2011-11-01

Full Text Available Oomycete pathogens cause diverse plant diseases. To successfully colonize their hosts, they deliver a suite of effector proteins that can attenuate plant defenses. In the oomycete downy mildews, effectors carry a signal peptide and an RxLR motif. Hyaloperonospora arabidopsidis (Hpa causes downy mildew on the model plant Arabidopsis thaliana (Arabidopsis. We investigated if candidate effectors predicted in the genome sequence of Hpa isolate Emoy2 (HaRxLs were able to manipulate host defenses in different Arabidopsis accessions. We developed a rapid and sensitive screening method to test HaRxLs by delivering them via the bacterial type-three secretion system (TTSS of Pseudomonas syringae pv tomato DC3000-LUX (Pst-LUX and assessing changes in Pst-LUX growth in planta on 12 Arabidopsis accessions. The majority (~70% of the 64 candidates tested positively contributed to Pst-LUX growth on more than one accession indicating that Hpa virulence likely involves multiple effectors with weak accession-specific effects. Further screening with a Pst mutant (ΔCEL showed that HaRxLs that allow enhanced Pst-LUX growth usually suppress callose deposition, a hallmark of pathogen-associated molecular pattern (PAMP-triggered immunity (PTI. We found that HaRxLs are rarely strong avirulence determinants. Although some decreased Pst-LUX growth in particular accessions, none activated macroscopic cell death. Fewer HaRxLs conferred enhanced Pst growth on turnip, a non-host for Hpa, while several reduced it, consistent with the idea that turnip's non-host resistance against Hpa could involve a combination of recognized HaRxLs and ineffective HaRxLs. We verified our results by constitutively expressing in Arabidopsis a sub-set of HaRxLs. Several transgenic lines showed increased susceptibility to Hpa and attenuation of Arabidopsis PTI responses, confirming the HaRxLs' role in Hpa virulence. This study shows TTSS screening system provides a useful tool to test whether

Monitored Retrievable Storage conceptual system studies: closed-cycle vault

International Nuclear Information System (INIS)

Washington, J.A.; Ganley, J.T.

1984-02-01

The Nuclear Waste Policy Act of 1982 requires the DOE to submit a proposal to Congress by June 1985 for the construction of one or more Monitored Retrieval Storage (MRS) facilities. In response, the DOE initiated studies to develop system descriptions and cost estimates for preconceptual designs of storage concepts suitable for use at MRS facilities. This report provides a system description and cost estimates for a Closed-Cycle Vault (CCV) MRS facility. The facility description is divided into four parts: (1) the R and H area, (2) the interface facility, (3) the on-site transport system, and (4) the storage system. The MRS facility has been designed to meet handling rates of 1800 and 3000 MTU/yr. The corresponding peak inventories are 15,000 and 72,000 MTU. Three types of cases were considered, based on the material to be stored: (1) Spent fuel only; (2) HLW and TRU waste; and (3) HLW only. For each of these three types, a cost estimate was done for a 15,000 and a 72,000 MTU facility, resulting in six different cost estimates. Section 4 presents the cost analysis of the CCV MRS system. Tables 4-2 through 4-7 give the construction or capital costs for the six cases. Tables 4-8 through 4-13 show the total discounted life-cycle costs for each of the six cases. These life-cycle costs include operating and decommissioning costs. These tables also show the time distribution of the capital costs. Table 2-1 summarizes the capital, operating, and discounted costs for the six cases studied. 2 references, 15 figures, 18 tables

LACK OF INFLATED RADII FOR KEPLER GIANT PLANET CANDIDATES RECEIVING MODEST STELLAR IRRADIATION

International Nuclear Information System (INIS)

Demory, Brice-Olivier; Seager, Sara

2011-01-01

The most irradiated transiting hot Jupiters are characterized by anomalously inflated radii, sometimes exceeding Jupiter's size by more than 60%. While different theoretical explanations have been applied, none of them provide a universal resolution to this observation, despite significant progress in the past years. We refine the photometric transit light curve analysis of 115 Kepler giant planet candidates based on public Q0-Q2 photometry. We find that 14% of them are likely false positives, based on their secondary eclipse depth. We report on planet radii versus stellar flux. We find an increase in planet radii with increased stellar irradiation for the Kepler giant planet candidates, in good agreement with existing hot Jupiter systems. We find that in the case of modest irradiation received from the stellar host, giant planets do not have inflated radii, and appear to have radii independent of the host star incident flux. This finding suggests that the physical mechanisms inflating hot Jupiters become ineffective below a given orbit-averaged stellar irradiation level of ∼2 × 10 8 erg s –1 cm –2 .

Comparison of lithium and the eutectic lead lithium alloy, two candidate liquid metal breeder materials for self-cooled blankets

International Nuclear Information System (INIS)

Malang, S.; Mattas, R.

1994-06-01

Liquid metals are attractive candidates for both near-term and long-term fusion applications. The subjects of this comparison are the differences between the two candidate liquid metal breeder materials Li and LiPb for use in breeding blankets in the areas of neutronics, magnetohydrodynamics, tritium control, compatibility with structural materials, heat extraction system, safety, and required R ampersand D program. Both candidates appear to be promising for use in self-cooled breeding blankets which have inherent simplicity with the liquid metal serving as both breeders and coolant. The remaining feasibility question for both breeder materials is the electrical insulation between liquid metal and duct walls. Different ceramic coatings are required for the two breeders, and their crucial issues, namely self-healing of insulator cracks and radiation induced electrical degradation are not yet demonstrated. Each liquid metal breeder has advantages and concerns associated with it, and further development is needed to resolve these concerns

Limits on surface gravities of Kepler planet-candidate host stars from non-detection of solar-like oscillations

Energy Technology Data Exchange (ETDEWEB)

Campante, T. L.; Chaplin, W. J.; Handberg, R.; Miglio, A.; Davies, G. R.; Elsworth, Y. P. [School of Physics and Astronomy, University of Birmingham, Edgbaston, Birmingham B15 2TT (United Kingdom); Lund, M. N.; Arentoft, T.; Christensen-Dalsgaard, J.; Karoff, C.; Kjeldsen, H.; Lundkvist, M. [Stellar Astrophysics Centre (SAC), Department of Physics and Astronomy, Aarhus University, Ny Munkegade 120, DK-8000 Aarhus C (Denmark); Huber, D. [NASA Ames Research Center, MS 244-30, Moffett Field, CA 94035 (United States); Hekker, S. [Astronomical Institute, " Anton Pannekoek," University of Amsterdam, Amsterdam (Netherlands); García, R. A. [Laboratoire AIM, CEA/DSM-CNRS-Université Paris Diderot (France); IRFU/SAp, Centre de Saclay, F-91191 Gif-sur-Yvette Cedex (France); Corsaro, E. [Instituut voor Sterrenkunde, KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Basu, S. [Department of Astronomy, Yale University, New Haven, CT 06520 (United States); Bedding, T. R. [Sydney Institute for Astronomy, School of Physics, University of Sydney, Sydney (Australia); Gilliland, R. L. [Center for Exoplanets and Habitable Worlds, The Pennsylvania State University, University Park, PA 16802 (United States); Kawaler, S. D., E-mail: campante@bison.ph.bham.ac.uk [Department of Physics and Astronomy, Iowa State University, Ames, IA 50011 (United States); and others

2014-03-10

We present a novel method for estimating lower-limit surface gravities (log g) of Kepler targets whose data do not allow the detection of solar-like oscillations. The method is tested using an ensemble of solar-type stars observed in the context of the Kepler Asteroseismic Science Consortium. We then proceed to estimate lower-limit log g for a cohort of Kepler solar-type planet-candidate host stars with no detected oscillations. Limits on fundamental stellar properties, as provided by this work, are likely to be useful in the characterization of the corresponding candidate planetary systems. Furthermore, an important byproduct of the current work is the confirmation that amplitudes of solar-like oscillations are suppressed in stars with increased levels of surface magnetic activity.

Human Health Safety Evaluation of Halon Replacement Candidates

National Research Council Canada - National Science Library

Dodd, D. E; Jepson, G. W; Macko, Jr, J. A

2000-01-01

.... The services within the Department of Defense (DoD) are directed to determine and evaluate suitable halon replacement candidates that will optimize performance of mission-essential equipment and operations...

Identification and Analysis of Future Aeronautical Communications Candidates: A Study of Concepts and Technologies to Support the Aeronautical Communications Needs in the NextGen and Beyond National Airspace System

Science.gov (United States)

Wichgers, Joel M.; Mitchell, James P.

2015-01-01

This report describes the results of future aeronautical communications research conducted by Rockwell Collins employees under NRA contract to NASA. The overall goal of this research was to identify and begin to evaluate communication technology candidates expected to meet the long-term aircraft-to-aircraft and aircraft-to-ground data communications needs of Air Traffic Management in the NextGen and beyond National Airspace System (NAS), considering how the NAS and communications technologies will evolve during a 50-year modernization time horizon.

Systematic evaluation of candidate blood markers for detecting ovarian cancer.

Directory of Open Access Journals (Sweden)

Chana Palmer

2008-07-01

Full Text Available Epithelial ovarian cancer is a significant cause of mortality both in the United States and worldwide, due largely to the high proportion of cases that present at a late stage, when survival is extremely poor. Early detection of epithelial ovarian cancer, and of the serous subtype in particular, is a promising strategy for saving lives. The low prevalence of ovarian cancer makes the development of an adequately sensitive and specific test based on blood markers very challenging. We evaluated the performance of a set of candidate blood markers and combinations of these markers in detecting serous ovarian cancer.We selected 14 candidate blood markers of serous ovarian cancer for which assays were available to measure their levels in serum or plasma, based on our analysis of global gene expression data and on literature searches. We evaluated the performance of these candidate markers individually and in combination by measuring them in overlapping sets of serum (or plasma samples from women with clinically detectable ovarian cancer and women without ovarian cancer. Based on sensitivity at high specificity, we determined that 4 of the 14 candidate markers--MUC16, WFDC2, MSLN and MMP7--warrant further evaluation in precious serum specimens collected months to years prior to clinical diagnosis to assess their utility in early detection. We also reported differences in the performance of these candidate blood markers across histological types of epithelial ovarian cancer.By systematically analyzing the performance of candidate blood markers of ovarian cancer in distinguishing women with clinically apparent ovarian cancer from women without ovarian cancer, we identified a set of serum markers with adequate performance to warrant testing for their ability to identify ovarian cancer months to years prior to clinical diagnosis. We argued for the importance of sensitivity at high specificity and of magnitude of difference in marker levels between cases and

PRE-SPECTROSCOPIC FALSE-POSITIVE ELIMINATION OF KEPLER PLANET CANDIDATES

International Nuclear Information System (INIS)

Batalha, Natalie M.; Rowe, Jason F.; Borucki, William J.; Koch, David G.; Lissauer, Jack J.; Gilliland, Ronald L.; Jenkins, Jon J.; Caldwell, Douglas; Dunham, Edward W.; Gautier, Thomas N.; Howell, Steve B.; Latham, David W.; Marcy, Geoff W.; Prsa, Andrej

2010-01-01

Ten days of commissioning data (Quarter 0) and 33 days of science data (Quarter 1) yield instrumental flux time series of ∼150,000 stars that were combed for transit events, termed threshold crossing events(TCE), each having a total detection statistic above 7.1σ. TCE light curves are modeled as star+planet systems. Those returning a companion radius smaller than 2R J are assigned a Kepler Object of Interest (KOI) number. The raw flux, pixel flux, and flux-weighted centroids of every KOI are scrutinized to assess the likelihood of being an astrophysical false positive versus the likelihood of being a planetary companion. This vetting using Kepler data is referred to as data validation (DV). Herein, we describe the DV metrics and graphics used to identify viable planet candidates amongst the KOIs. Light curve modeling tests for (1) the difference in depth of the odd- versus even-numbered transits, (2) evidence of ellipsoidal variations, and (3) evidence of a secondary eclipse event at phase = 0.5. Flux-weighted centroids are used to test for signals correlated with transit events with a magnitude and direction indicative of a background eclipsing binary. Centroid time series are complimented by analysis of images taken in-transit versus out-of-transit, the difference often revealing the pixel contributing the most to the flux change during transit. Examples are shown to illustrate each test. Candidates passing DV are submitted to ground-based observers for further false-positive elimination or confirmation/characterization.

The cld mutation: narrowing the critical chromosomal region and selecting candidate genes.

Science.gov (United States)

Péterfy, Miklós; Mao, Hui Z; Doolittle, Mark H

2006-10-01

Combined lipase deficiency (cld) is a recessive, lethal mutation specific to the tw73 haplotype on mouse Chromosome 17. While the cld mutation results in lipase proteins that are inactive, aggregated, and retained in the endoplasmic reticulum (ER), it maps separately from the lipase structural genes. We have narrowed the gene critical region by about 50% using the tw18 haplotype for deletion mapping and a recombinant chromosome used originally to map cld with respect to the phenotypic marker tf. The region now extends from 22 to 25.6 Mbp on the wild-type chromosome, currently containing 149 genes and 50 expressed sequence tags (ESTs). To identify the affected gene, we have selected candidates based on their known role in associated biological processes, cellular components, and molecular functions that best fit with the predicted function of the cld gene. A secondary approach was based on differences in mRNA levels between mutant (cld/cld) and unaffected (+/cld) cells. Using both approaches, we have identified seven functional candidates with an ER localization and/or an involvement in protein maturation and folding that could explain the lipase deficiency, and six expression candidates that exhibit large differences in mRNA levels between mutant and unaffected cells. Significantly, two genes were found to be candidates with regard to both function and expression, thus emerging as the strongest candidates for cld. We discuss the implications of our mapping results and our selection of candidates with respect to other genes, deletions, and mutations occurring in the cld critical region.

Gravitino, dark matter candidate and implications for big bang nucleosynthesis

International Nuclear Information System (INIS)

Bailly, S.

2008-11-01

The Standard Model of particle physics was developed in the seventies. Despite many experimental successes, it presents many problems that can only be solved with models beyond the Standard Model. Supersymmetry is an interesting candidate, postulating a new symmetry between fermions and bosons. This model can also have interesting applications in cosmology. It offers potentially good candidates for dark matter, what represents 25% of the energy density of the Universe, and its nature is unknown. Another cosmological problem is the lithium problems in Big Bang Nucleosynthesis describing the production of light elements in the first seconds of the Universe. The lithium abundance predicted by the theory is inconsistent with observations. I study a scenario in which a supersymmetric particle, the gravitino, is the candidate for dark matter and the production of this particle through the decay of other supersymmetric particles may solve the lithium problems. (author)

No Evidence That Schizophrenia Candidate Genes Are More Associated With Schizophrenia Than Noncandidate Genes.

Science.gov (United States)

Johnson, Emma C; Border, Richard; Melroy-Greif, Whitney E; de Leeuw, Christiaan A; Ehringer, Marissa A; Keller, Matthew C

2017-11-15

A recent analysis of 25 historical candidate gene polymorphisms for schizophrenia in the largest genome-wide association study conducted to date suggested that these commonly studied variants were no more associated with the disorder than would be expected by chance. However, the same study identified other variants within those candidate genes that demonstrated genome-wide significant associations with schizophrenia. As such, it is possible that variants within historic schizophrenia candidate genes are associated with schizophrenia at levels above those expected by chance, even if the most-studied specific polymorphisms are not. The present study used association statistics from the largest schizophrenia genome-wide association study conducted to date as input to a gene set analysis to investigate whether variants within schizophrenia candidate genes are enriched for association with schizophrenia. As a group, variants in the most-studied candidate genes were no more associated with schizophrenia than were variants in control sets of noncandidate genes. While a small subset of candidate genes did appear to be significantly associated with schizophrenia, these genes were not particularly noteworthy given the large number of more strongly associated noncandidate genes. The history of schizophrenia research should serve as a cautionary tale to candidate gene investigators examining other phenotypes: our findings indicate that the most investigated candidate gene hypotheses of schizophrenia are not well supported by genome-wide association studies, and it is likely that this will be the case for other complex traits as well. Copyright © 2017 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

A VOLUME-LIMITED PHOTOMETRIC SURVEY OF 114 γ DORADUS CANDIDATES

International Nuclear Information System (INIS)

Henry, Gregory W.; Fekel, Francis C.; Henry, Stephen M.

2011-01-01

We have carried out a photometric survey of a complete, volume-limited sample of γ Doradus candidates. The sample was extracted from the Hipparcos catalog and consists of 114 stars with colors and absolute magnitudes within the range of known γ Doradus stars and that also lie within a specified volume of 266,600 pc 3 . We devoted one year of observing time with our T12 0.8 m automatic photometric telescope to acquire nightly observations of the complete sample of stars. From these survey observations, we identify 37 stars with intrinsic variability of 0.002 mag or more. Of these 37 variables, 8 have already been confirmed as γ Doradus stars in our earlier papers; we scheduled the remaining 29 variables on our T3 0.4 m automatic telescope to acquire more intensive observations over the next two years. As promising new γ Doradus candidates were identified from the photometry, we obtained complementary spectroscopic observations of each candidate with the Kitt Peak coude feed telescope. Analysis of our new photometric and spectroscopic data reveals 15 new γ Doradus variables (and confirms two others), 8 new δ Scuti variables (and confirms one other), and 3 new variables with unresolved periodicity. Therefore, of the 114 γ Doradus candidates in our volume-limited sample, we find 25 stars that are new or previously known γ Doradus variables. This results in an incidence of 22% for γ Doradus variability among candidate field stars for this volume of the solar neighborhood. The corresponding space density of γ Doradus stars in this volume of space is 0.094 stars per 10 3 pc 3 or 94 stars per 10 6 pc 3 . We provide an updated list of 86 bright, confirmed, γ Doradus field stars.

The CHAOS-3 Geomagnetic Field Model and Candidates for the 11th Generation IGRF

DEFF Research Database (Denmark)

Olsen, Nils; Mandea, Mioara; Sabaka, Terence J.

2010-01-01

As a part of the 11th generation IGRF defined by IAGA, we propose a candidate model for the DGRF 2005, a candidate model for IGRF 2010 and a candidate model for the mean secular variation between 2010 and 2015. These candidate models, the derivation of which is described in the following, are bas...... = 20, described by order 6 splines (with 6-month knot spacing) spanning the time interval 1997.0–2010.0. The third time derivative of the squared magnetic field intensity is regularized at the core-mantle boundary. No spatial regularization is applied....

Self-Efficacy of Teacher Candidates for Teaching First Reading and Writing

Science.gov (United States)

Gündogmus, Hatice Degirmenci

2018-01-01

The purpose of this study is to determine by different variables the self-efficacy of a teacher candidate for teaching first reading and writing in their 3rd and 4th year in the department of primary school teaching. In line with the purpose of the study, the self-efficacy levels of teacher candidates for teaching first reading and writing were…

Characterizing K2 Candidate Planetary Systems Orbiting Low-Mass Stars. I. Classifying Low-Mass Host Stars Observed During Campaigns 1-7

Science.gov (United States)

Dressing, Courtney D.; Newton, Elisabeth R.; Schlieder, Joshua E.; Charbomeau, David; Krutson, Heather A.; Vanderburg, Andrew; Sinukoff, Evan

2017-01-01

We present near-infrared spectra for 144 candidate planetary systems identified during Campaigns 1-7 of the NASA K2 Mission. The goal of the survey was to characterize planets orbiting low-mass stars, but our Infrared Telescope Facility/SpeX and Palomar/TripleSpec spectroscopic observations revealed that 49% of our targets were actually giant stars or hotter dwarfs reddened by interstellar extinction. For the 72 stars with spectra consistent with classification as cool dwarfs (spectral types K3-M4), we refined their stellar properties by applying empirical relations based on stars with interferometric radius measurements. Although our revised temperatures are generally consistent with those reported in the Ecliptic Plane Input Catalog (EPIC), our revised stellar radii are typically 0.13 solar radius (39%) larger than the EPIC values, which were based on model isochrones that have been shown to underestimate the radii of cool dwarfs. Our improved stellar characterizations will enable more efficient prioritization of K2 targets for follow-up studies.

SpeX spectroscopy of unresolved very low mass binaries. II. Identification of 14 candidate binaries with late-M/early-L and T dwarf components

International Nuclear Information System (INIS)

Bardalez Gagliuffi, Daniella C.; Burgasser, Adam J.; Nicholls, Christine P.; Gelino, Christopher R.; Looper, Dagny L.; Schmidt, Sarah J.; Cruz, Kelle; West, Andrew A.; Gizis, John E.; Metchev, Stanimir

2014-01-01

Multiplicity is a key statistic for understanding the formation of very low mass (VLM) stars and brown dwarfs. Currently, the separation distribution of VLM binaries remains poorly constrained at small separations (≤1 AU), leading to uncertainty in the overall binary fraction. We approach this problem by searching for late-M/early-L plus T dwarf spectral binaries whose combined light spectra exhibit distinct peculiarities, allowing for separation-independent identification. We define a set of spectral indices designed to identify these systems, and we use a spectral template fitting method to confirm and characterize spectral binary candidates from a library of 815 spectra from the SpeX Prism Spectral Libraries. We present 11 new binary candidates, confirm 3 previously reported candidates, and rule out 2 previously identified candidates, all with primary and secondary spectral types in the range M7-L7 and T1-T8, respectively. We find that subdwarfs and blue L dwarfs are the primary contaminants in our sample and propose a method for segregating these sources. If confirmed by follow-up observations, these systems may add to the growing list of tight separation binaries, whose orbital properties may yield further insight into brown dwarf formation scenarios.

Supermassive Black Hole Binary Candidates from the Pan-STARRS1 Medium Deep Survey

Science.gov (United States)

Liu, Tingting; Gezari, Suvi

2018-01-01

Supermassive black hole binaries (SMBHBs) should be a common product of the hierarchal growth of galaxies and gravitational wave sources at nano-Hz frequencies. We have performed a systematic search in the Pan-STARRS1 Medium Deep Survey for periodically varying quasars, which are predicted manifestations of SMBHBs, and identified 26 candidates that are periodically varying on the timescale of ~300-1000 days over the 4-year baseline of MDS. We continue to monitor them with the Discovery Channel Telescope and the LCO network telescopes and thus are able to extend the baseline to 3-8 cycles and break false positive signals due to stochastic, normal quasar variability. From our imaging campaign, five candidates show persistent periodic variability and remain strong SMBHB candidates for follow-up observations. We calculate the cumulative number rate of SMBHBs and compare with previous work. We also compare the gravitational wave strain amplitudes of the candidates with the capability of pulsar timing arrays and discuss the future capabilities to detect periodic quasar and SMBHB candidates with the Large Synoptic Survey Telescope.

PHOTOMETRIC TYPE Ia SUPERNOVA CANDIDATES FROM THE THREE-YEAR SDSS-II SN SURVEY DATA

International Nuclear Information System (INIS)

Sako, Masao; Connolly, Brian; Gladney, Larry; Bassett, Bruce; Dilday, Benjamin; Cambell, Heather; Lampeitl, Hubert; Nichol, Robert C.; Frieman, Joshua A.; Kessler, Richard; Marriner, John; Miquel, Ramon; Schneider, Donald P.; Smith, Mathew; Sollerman, Jesper

2011-01-01

We analyze the three-year Sloan Digital Sky Survey II (SDSS-II) Supernova (SN) Survey data and identify a sample of 1070 photometric Type Ia supernova (SN Ia) candidates based on their multiband light curve data. This sample consists of SN candidates with no spectroscopic confirmation, with a subset of 210 candidates having spectroscopic redshifts of their host galaxies measured while the remaining 860 candidates are purely photometric in their identification. We describe a method for estimating the efficiency and purity of photometric SN Ia classification when spectroscopic confirmation of only a limited sample is available, and demonstrate that SN Ia candidates from SDSS-II can be identified photometrically with ∼91% efficiency and with a contamination of ∼6%. Although this is the largest uniform sample of SN candidates to date for studying photometric identification, we find that a larger spectroscopic sample of contaminating sources is required to obtain a better characterization of the background events. A Hubble diagram using SN candidates with no spectroscopic confirmation, but with host galaxy spectroscopic redshifts, yields a distance modulus dispersion that is only ∼20%-40% larger than that of the spectroscopically confirmed SN Ia sample alone with no significant bias. A Hubble diagram with purely photometric classification and redshift-distance measurements, however, exhibits biases that require further investigation for precision cosmology.

Photometric type Ia supernova candidates from the three-year SDSS-II SN survey data

Energy Technology Data Exchange (ETDEWEB)

Sako, Masao; /Pennsylvania U.; Bassett, Bruce; /South African Astron. Observ. /Cape Town U., Dept. Math.; Connolly, Brian; /Pennsylvania U.; Dilday, Benjamin; /Las Cumbres Observ. /UC, Santa Barbara /Rutgers U., Piscataway; Cambell, Heather; /Portsmouth U., ICG; Frieman, Joshua A.; /Chicago U. /Chicago U., KICP /Fermilab; Gladney, Larry; /Pennsylvania U.; Kessler, Richard; /Chicago U. /Chicago U., KICP; Lampeitl, Hubert; /Portsmouth U., ICG; Marriner, John; /Fermilab; Miquel, Ramon; /Barcelona, IFAE /ICREA, Barcelona /Portsmouth U., ICG

2011-07-01

We analyze the three-year Sloan Digital Sky Survey II (SDSS-II) Supernova (SN) Survey data and identify a sample of 1070 photometric Type Ia supernova (SN Ia) candidates based on their multiband light curve data. This sample consists of SN candidates with no spectroscopic confirmation, with a subset of 210 candidates having spectroscopic redshifts of their host galaxies measured while the remaining 860 candidates are purely photometric in their identification. We describe a method for estimating the efficiency and purity of photometric SN Ia classification when spectroscopic confirmation of only a limited sample is available, and demonstrate that SN Ia candidates from SDSS-II can be identified photometrically with {approx}91% efficiency and with a contamination of {approx}6%. Although this is the largest uniform sample of SN candidates to date for studying photometric identification, we find that a larger spectroscopic sample of contaminating sources is required to obtain a better characterization of the background events. A Hubble diagram using SN candidates with no spectroscopic confirmation, but with host galaxy spectroscopic redshifts, yields a distance modulus dispersion that is only {approx}20%-40% larger than that of the spectroscopically confirmed SN Ia sample alone with no significant bias. A Hubble diagram with purely photometric classification and redshift-distance measurements, however, exhibits biases that require further investigation for precision cosmology.

A Data-Driven Voter Guide for U.S. Elections: Adapting Quantitative Measures of the Preferences and Priorities of Political Elites to Help Voters Learn About Candidates

Directory of Open Access Journals (Sweden)

Adam Bonica

2016-11-01

Full Text Available Internet-based voter advice applications have experienced tremendous growth across Europe in recent years but have yet to be widely adopted in the United States. By comparison, the candidate-centered U.S. electoral system, which routinely requires voters to consider dozens of candidates across a dizzying array of local, state, and federal offices each time they cast a ballot, introduces challenges of scale to the systematic provision of information. Only recently have methodological advances combined with the rapid growth in publicly available data on candidates and their supporters to bring a comprehensive data-driven voter guide within reach. This paper introduces a set of newly developed software tools for collecting, disambiguating, and merging large amounts of data on candidates and other political elites. It then demonstrates how statistical methods developed by political scientists to measure the preferences and expressed priorities of politicians can be adapted to help voters learn about candidates.

International Practica Experiences as Events of Influence in a Teacher Candidates' Development

Science.gov (United States)

Maynes, Nancy; Allison, John; Julien-Schultz, Lynn

2012-01-01

Experience may influence beliefs and beliefs may influence practices. Following these premises, we investigated teacher candidates' post experience reflections nine months after an international practicum where they taught for three weeks in rural Kenya. Teacher candidates were placed in non-governmental organization (NGO) sponsored schools on the…

Using TPACK as a Framework to Understand Teacher Candidates' Technology Integration Decisions

Science.gov (United States)

Graham, C. R.; Borup, J.; Smith, N. B.

2012-01-01

This research uses the technological pedagogical and content knowledge (TPACK) framework as a lens for understanding how teacher candidates make decisions about the use of information and communication technology in their teaching. Pre- and post-treatment assessments required elementary teacher candidates at Brigham Young University to articulate…

Relationship between Lifelong Learning Levels and Information Literacy Skills in Teacher Candidates

Science.gov (United States)

Solmaz, Dilek Yaliz

2017-01-01

This study aims to examine the relationship between lifelong learning levels and information literacy skills in teacher candidates. The research group consists of 127 physical education and sports teacher candidates. Data were collected by means of "Lifelong Learning Scale (LLL)" and "Information Literacy Scale". In the data…

Greenfield Alternative Study LEU-Mo Fuel Fabrication Facility

Energy Technology Data Exchange (ETDEWEB)

Washington Division of URS

2008-07-01

This report provides the initial “first look” of the design of the Greenfield Alternative of the Fuel Fabrication Capability (FFC); a facility to be built at a Greenfield DOE National Laboratory site. The FFC is designed to fabricate LEU-Mo monolithic fuel for the 5 US High Performance Research Reactors (HPRRs). This report provides a pre-conceptual design of the site, facility, process and equipment systems of the FFC; along with a preliminary hazards evaluation, risk assessment as well as the ROM cost and schedule estimate.

Optical observations of southern planetary nebula candidates

NARCIS (Netherlands)

VandeSteene, GC; Sahu, KC; Pottasch, [No Value

1996-01-01

We present H alpha+[NII] images and low resolution spectra of 16 IRAS-selected, southern planetary nebula candidates previously detected in the radio continuum. The H alpha+[NII] images are presented as finding charts. Contour plots are shown for the resolved planetary nebulae. From these images

Functional validation of candidate genes detected by genomic feature models

DEFF Research Database (Denmark)

Rohde, Palle Duun; Østergaard, Solveig; Kristensen, Torsten Nygaard

2018-01-01

Understanding the genetic underpinnings of complex traits requires knowledge of the genetic variants that contribute to phenotypic variability. Reliable statistical approaches are needed to obtain such knowledge. In genome-wide association studies, variants are tested for association with trait...... then functionally assessed whether the identified candidate genes affected locomotor activity by reducing gene expression using RNA interference. In five of the seven candidate genes tested, reduced gene expression altered the phenotype. The ranking of genes within the predictive GO term was highly correlated...

Degrees of separation as a statistical tool for evaluating candidate genes.

Science.gov (United States)

Nelson, Ronald M; Pettersson, Mats E

2014-12-01

Selection of candidate genes is an important step in the exploration of complex genetic architecture. The number of gene networks available is increasing and these can provide information to help with candidate gene selection. It is currently common to use the degree of connectedness in gene networks as validation in Genome Wide Association (GWA) and Quantitative Trait Locus (QTL) mapping studies. However, it can cause misleading results if not validated properly. Here we present a method and tool for validating the gene pairs from GWA studies given the context of the network they co-occur in. It ensures that proposed interactions and gene associations are not statistical artefacts inherent to the specific gene network architecture. The CandidateBacon package provides an easy and efficient method to calculate the average degree of separation (DoS) between pairs of genes to currently available gene networks. We show how these empirical estimates of average connectedness are used to validate candidate gene pairs. Validation of interacting genes by comparing their connectedness with the average connectedness in the gene network will provide support for said interactions by utilising the growing amount of gene network information available. Copyright © 2014 Elsevier Ltd. All rights reserved.

Patients who are candidates for subacromial decompression have more pronounced range of motion deficits, but do not differ in self-reported shoulder function, strength or pain compared to non-candidates

DEFF Research Database (Denmark)

Witten, Adam; Clausen, Mikkel B; Thorborg, Kristian

2018-01-01

-reported shoulder function, shoulder strength, ROM, and pain in patients with SIS considered candidates and non-candidates for subacromial decompression (SAD). METHOD: Self-reported shoulder function (Q-DASH and SPADI), maximum isometric muscle strength in shoulder abduction (Abd-strength) and external rotation (ER...... or non-candidates for SAD based on their consultation with an orthopedic specialist blinded to test results and self-reported shoulder function. All outcomes and age, gender, weight and duration of symptoms were compared using the unpaired t test or Mann-Whitney's U test as appropriate. RESULTS: One.......3 vs. 3.7, p = 0.02, effect size = 0.21). No other differences were found between the groups. CONCLUSION: A decrease in abduction and internal rotation range of motion, and increased pain during maximal abduction strength effort are associated with being considered a candidate for subacromial...

Spitzer Photometry of WISE-Selected Brown Dwarf and Hyper-Lumninous Infrared Galaxy Candidates

Science.gov (United States)

Griffith, Roger L.; Kirkpatrick, J. Davy; Eisenhardt, Peter R. M.; Gelino, Christopher R.; Cushing, Michael C.; Benford, Dominic; Blain, Andrew; Bridge, Carrie R.; Cohen, Martin; Cutri, Roc M.;

Examining Cyberbullying Tendency and Multidimensional Perceived Social Support Status of Teacher Candidates

Science.gov (United States)

Levent, Faruk; Taçgin, Zeynep

2017-01-01

The teachers have a substantial role for students through consciously the Internet usage and struggle with cyberbullying. The purpose of this study is to investigate cyberbullying tendency and multidimensional perceived social support status of the teacher candidates. The participants of this research have become 412 teacher candidates as…

Mutually Beneficial Service Learning: Language Teacher Candidates in a Local Community Center

Science.gov (United States)

Hildebrandt, Susan A.

2014-01-01

This article reports on a project designed to provide mutually beneficial solutions to challenges faced by world language teacher candidates, their preparation program, and a local community center. The project provided opportunities for teacher candidates enrolled in a world language (WL) teacher education course to complete clinical experiences…

New VVV Survey Globular Cluster Candidates in the Milky Way Bulge

Energy Technology Data Exchange (ETDEWEB)

Minniti, Dante; Gómez, Matías [Departamento de Física, Facultad de Ciencias Exactas, Universidad Andrés Bello, Av. Fernandez Concha 700, Las Condes, Santiago (Chile); Geisler, Douglas; Fernández-Trincado, Jose G. [Departamento de Astronomía, Casilla 160-C, Universidad de Concepción, Casilla 160-C, Concepción (Chile); Alonso-García, Javier; Beamín, Juan Carlos; Borissova, Jura; Catelan, Marcio; Ramos, Rodrigo Contreras; Kurtev, Radostin; Pullen, Joyce [Instituto Milenio de Astrofísica, Santiago (Chile); Palma, Tali; Clariá, Juan J. [Observatorio Astronómico, Universidad Nacional de Córdoba, Laprida 854, Córdoba (Argentina); Cohen, Roger E. [Space Telescope Science Institute, 2700 San Martin Drive, Baltimore (United States); Dias, Bruno [European Southern Observatory, Alonso de Cordova 3107, Vitacura, Santiago (Chile); Hempel, Maren [Pontificia Universidad Católica de Chile, Instituto de Astrofísica, Av. Vicuña Mackenna 4860, Santiago (Chile); Ivanov, Valentin D. [European Southern Observatory, Karl-Schwarszchild-Str. 2, D-85748 Garching bei Muenchen (Germany); Lucas, Phillip W. [Dept. of Astronomy, University of Hertfordshire, Hertfordshire (United Kingdom); Moni-Bidin, Christian; Alegría, Sebastian Ramírez [Instituto de Astronomía, Universidad Católica del Norte, Antofagasta (Chile); and others

2017-11-10

It is likely that a number of Galactic globular clusters remain to be discovered, especially toward the Galactic bulge. High stellar density combined with high and differential interstellar reddening are the two major problems for finding globular clusters located toward the bulge. We use the deep near-IR photometry of the VISTA Variables in the Vía Láctea (VVV) Survey to search for globular clusters projected toward the Galactic bulge, and hereby report the discovery of 22 new candidate globular clusters. These objects, detected as high density regions in our maps of bulge red giants, are confirmed as globular cluster candidates by their color–magnitude diagrams. We provide their coordinates as well as their near-IR color–magnitude diagrams, from which some basic parameters are derived, such as reddenings and heliocentric distances. The color–magnitude diagrams reveal well defined red giant branches in all cases, often including a prominent red clump. The new globular cluster candidates exhibit a variety of extinctions (0.06 < A {sub Ks} < 2.77) and distances (5.3 < D < 9.5 kpc). We also classify the globular cluster candidates into 10 metal-poor and 12 metal-rich clusters, based on the comparison of their color–magnitude diagrams with those of known globular clusters also observed by the VVV Survey. Finally, we argue that the census for Galactic globular clusters still remains incomplete, and that many more candidate globular clusters (particularly the low luminosity ones) await to be found and studied in detail in the central regions of the Milky Way.

X-ray counterpart candidates for six new γ-ray pulsars

Science.gov (United States)

Zyuzin, Dmitry A.; Karpova, Anna V.; Shibanov, Yuriy A.

2018-05-01

Using archival X-ray data, we have found point-like X-ray counterpart candidates positionally coincident with six γ-ray pulsars discovered recently in the Fermi Gamma-ray Space Telescope data by the Einstein@Home project. The candidates for PSRs J0002+6216, J0554+3107, J1844-0346, and J1105-6037 are detected with Swift, and those for PSRs J0359+5414 and J2017+3625 are detected with Chandra. Despite a low count statistics for some candidates, assuming plausible constraints on the absorbing column density towards the pulsars, we show that X-ray spectral properties for all of them are consistent with those observed for other pulsars. J0359+5414 is the most reliably identified object. We detect a nebula around it, whose spectrum and extent suggest that this is a pulsar wind nebula powered by the pulsar. Associations of J0002+6216 and J1844-0346 with supernova remnants CTB 1 and G28.6-0.1 are proposed.

Candidate W+Z double leptonic decay event of the ATLAS experiment

CERN Multimedia

ATLAS, Experiment

2014-01-01

Candidate W+Z double leptonic decay event. Candidate for a WZ ->eνμμ decay, collected on 7 October 2010. The invariant mass of the two muons is 96 GeV. The transverse mass of the potential W boson is 57 GeV. Further event properties: PT(μ+) = 65 GeV PT(μ-) = 40 GeV PT(e) = 64 GeV ETmiss = 21 GeV

Voices of Teacher Candidates of Color on White Race Evasion: "I Worried about My Safety!"

Science.gov (United States)

Amos, Yukari Takimoto

2016-01-01

This qualitative study investigated the negative impacts minority teacher candidates receive from white teacher candidates in a required multicultural education class. The findings reveal that four teacher candidates of color had difficulty positioning themselves among the overwhelming silencing power of whiteness in the class. The white students…

The FRCR 2B examination: a survey of candidate perceptions and experiences

International Nuclear Information System (INIS)

Yeung, A.; Booth, T.C.; Jacob, K.; McCoubrie, P.; McKnight, L.

2011-01-01

Aim: To survey the views of recent candidates of the Fellowship of the Royal College of Radiologists (FRCR) 2B examination with reference to assessment validity, reliability, and acceptability. Materials and methods: One thousand, two hundred and four UK radiology trainees and consultants were invited to complete an automated internet questionnaire regarding their experiences and perceptions of the FRCR 2B examination. The questionnaire was informed by a review of the literature. Eligible participants were candidates who had taken the examination within the previous 3 years. Results: Four hundred and ninety-seven out of 1204 (41%) responses were received; of which 258/497 (52% of respondents) were eligible for inclusion into the study. The rapid reporting component is perceived to be significantly fairer than the oral section (82 versus 70% agree; p < 0.001). The oral component fared poorly in perceived performance-reducing anxiety levels but well in questions relating to validity and reliability. Female candidates are more likely to find the FRCR 2B unfair (p = 0.01) and experience performance-reducing anxiety (p < 0.001) than males. No gender differences were observed in first-time pass rates (p = 0.6). Candidate first language did not affect anxiety levels (p = 0.9) or first-time pass rates (p = 0.06). Only 12% of candidates agreed that the oral examination should move to an objective structured clinical format. Conclusion: Candidates score the FRCR 2B examination well in test validity with little desire for change to the oral examination format. Efforts to help reduce anxiety levels in the oral component would improve perceived fairness.

Diversifying Selection in the Wheat Stem Rust Fungus Acts Predominantly on Pathogen-Associated Gene Families and Reveals Candidate Effectors

Directory of Open Access Journals (Sweden)

Jana eSperschneider

2014-09-01

Full Text Available Plant pathogens cause severe losses to crop plants and threaten global food production. One striking example is the wheat stem rust fungus, Puccinia graminis f. sp. tritici, which can rapidly evolve new virulent pathotypes in response to resistant host lines. Like several other filamentous fungal and oomycete plant pathogens, its genome features expanded gene families that have been implicated in host-pathogen interactions, possibly encoding effector proteins that interact directly with target host defence proteins. Previous efforts to understand virulence largely relied on the prediction of secreted, small and cysteine-rich proteins as candidate effectors and thus delivered an overwhelming number of candidates. Here, we implement an alternative analysis strategy that uses the signal of adaptive evolution as a line of evidence for effector function, combined with comparative information and expression data. We demonstrate that in planta up-regulated genes that are rapidly evolving are found almost exclusively in pathogen-associated gene families, affirming the impact of host-pathogen co-evolution on genome structure and the adaptive diversification of specialised gene families. In particular, we predict 42 effector candidates that are conserved only across pathogens, induced during infection and rapidly evolving. One of our top candidates has recently been shown to induce genotype-specific hypersensitive cell death in wheat. This shows that comparative genomics incorporating the evolutionary signal of adaptation is powerful for predicting effector candidates for laboratory verification. Our system can be applied to a wide range of pathogens and will give insight into host-pathogen dynamics, ultimately leading to progress in strategies for disease control.

Candidates for non-baryonic dark matter

International Nuclear Information System (INIS)

Fornengo, Nicolao

2002-01-01

This report is a brief review of the efforts to explain the nature of non-baryonic dark matter and of the studies devoted to the search for relic particles. Among the different dark matter candidates, special attention is devoted to relic neutralinos, by giving an overview of the recent calculations of its relic abundance and detection rates in a wide variety of supersymmetric schemes

Candidates for non-baryonic dark matter

OpenAIRE

Fornengo, Nicolao

2002-01-01

This report is a brief review of the efforts to explain the nature of non-baryonic dark matter and of the studies devoted to the search for relic particles. Among the different dark matter candidates, special attention is devoted to relic neutralinos, by giving an overview of the recent calculations of its relic abundance and detection rates in a wide variety of supersymmetric schemes.

The role of candidate evaluations in the 2014 European Parliament elections: Towards the personalization of voting behaviour?

Science.gov (United States)

Gattermann, Katjana; De Vreese, Claes H

2017-09-01

We study the personalization of voting behaviour in European Parliament elections. We argue that information from the media is crucial for providing linkages between candidates and voters. Moreover, we contend that candidates can serve as information short-cuts given the complexity of European Union politics. We use a four-wave Dutch panel survey and a media study that enable us to link evaluations of lead candidates, party preferences, and vote choice to exposure to news about these candidates. We show, firstly, that exposure to candidate news is a strong explanatory factor for candidate recognition. Secondly, we find that candidate evaluations positively affect party choice, albeit mainly for those voters who tend to be politically aware. Our research has implications for debates about the European Union's accountability deficit.

Conducting Research from Small University Observatories: Investigating Exoplanet Candidates

Science.gov (United States)

Moreland, Kimberly D.

2018-01-01

Kepler has to date discovered 4,496 exoplanet candidates, but only half are confirmed, and only a handful are thought to be Earth sized and in the habitable zone. Planet verification often involves extensive follow-up observations, which are both time and resource intensive. The data set collected by Kepler is massive and will be studied for decades. University/small observatories, such as the one at Texas State University, are in a good position to assist with the exoplanet candidate verification process. By preforming extended monitoring campaigns, which are otherwise cost ineffective for larger observatories, students gain valuable research experience and contribute valuable data and results to the scientific community.

PLANETARY CANDIDATES FROM THE FIRST YEAR OF THE K2 MISSION

Energy Technology Data Exchange (ETDEWEB)

Vanderburg, Andrew; Latham, David W.; Bieryla, Allyson; Berlind, Perry; Calkins, Michael L.; Esquerdo, Gilbert A.; Welsh, Sophie; Johnson, John Asher [Harvard–Smithsonian Center for Astrophysics, 60 Garden St., Cambridge, MA 02138 (United States); Buchhave, Lars A., E-mail: avanderburg@cfa.harvard.edu [Centre for Star and Planet Formation, Natural History Museum of Denmark and Niels Bohr Institute, University of Copenhagen, Øster Voldgade 5-7, DK-1350 Copenhagen K (Denmark)

2016-01-15

The Kepler Space Telescope is currently searching for planets transiting stars along the ecliptic plane as part of its extended K2 mission. We processed the publicly released data from the first year of K2 observations (Campaigns 0, 1, 2, and 3) and searched for periodic eclipse signals consistent with planetary transits. Out of the 59,174 targets that we searched, we detect 234 planetary candidates around 208 stars. These candidates range in size from gas giants to smaller than the Earth, and range in orbital periods from hours to over a month. We conducted initial reconnaissance spectroscopy of 68 of the brighter candidate host stars, and present high-resolution optical spectra for these stars. We make all of our data products, including light curves, spectra, and vetting diagnostics available to users online.

Investigating Mathematics Teachers Candidates' Knowledge about Problem Solving Strategies through Problem Posing

Science.gov (United States)

Ünlü, Melihan

2017-01-01

The aim of the study was to determine mathematics teacher candidates' knowledge about problem solving strategies through problem posing. This qualitative research was conducted with 95 mathematics teacher candidates studying at education faculty of a public university during the first term of the 2015-2016 academic year in Turkey. Problem Posing…

Correlation between Teaching Styles of Candidate Music Teachers and Mentor Music Teachers

Science.gov (United States)

Ahmethan, Nurtug Bariseri

2016-01-01

Music teacher candidates spend part of their Bachelor education in practice schools with mentor teachers before starting work. Observing music teachers in the classroom empower candidates to understand how music teaching and learning occur in classrooms, and also enlightens them on how mentor teachers teach, which then expands their awareness…

Selection of candidate salad vegetables for controlled ecological life support system

Science.gov (United States)

Qin, L.; Guo, S.; Ai, W.; Tang, Y.

Higher plants, as one of the essential biological components of CELSS, can supply food, oxygen and water for human crews during future long-duration space missions and Lunar/Mars habitats. In order to select suitable leaf vegetable varieties for our CELSS Experimental Facility (CEF), five varieties of lettuce (“Nenlvnaiyou”, “Dasusheng”, “Naichoutai”, “Dongfangkaixuan” and “Siji”), two of spinach (“Daye” and “Quanneng”), one of rape (“Jingyou No. 1”) and one of common sowthistle were grown and compared on the basis of edible biomass, and nutrient content. In addition, two series of experiments were conducted to study single leaf photosynthetic rates and transpiration rates at 30 days after planting, one which used various concentrations of CO2 (500, 1000, 1500 and 2000 μmol mol-1) and another which used various light intensities (100, 300, 500 and 700 μmol m-2 s-1). Results showed that lettuce cvs. “Nenlvnaiyou”, “Siji” and “Dasusheng” produced higher yields of edible biomass; common sowthisle would be a good source of β-carotene for the diet. Based on the collective findings, we selected three varieties of lettuce (“Nenlvnaiyou”, “Dasusheng” and “Siji”) and one of common sowthistle as the candidate crops for further research in our CEF. In addition, elevated CO2 concentration increased the rates of photosynthesis and transpiration, and elevated light intensity increased the rate of photosynthesis for these varieties. These results can be useful for determining optimal conditions for controlling CO2 and water fluxes between the crops and the overall CELSS.

Comparison of alternative treatment systems for DOE mixed low-level waste

International Nuclear Information System (INIS)

Schwinkendorf, W.E.

1997-03-01

From 1993 to 1996, the Department of Energy, Environmental Management, Office of Science and Technology (OST), has sponsored a series of systems analyses to guide its future research and development (R ampersand D) programs for the treatment of mixed low-level waste (MLLW) stored in the DOE complex. The two original studies were of 20 mature and innovative thermal systems. As a result of a technical review of these thermal system studies, a similar study of five innovative nonthermal systems was conducted in which unit operations are limited to temperatures less than 350 degrees C to minimize volatilization of heavy metals and radionuclides, and de novo production of dioxins and furans in the offgas. Public involvement in the INTS study was established through a working group of 20 tribal and stakeholder representatives to provide input to the INTS studies and identify principles against which the systems should be designed and evaluated. Pre-conceptual designs were developed for all systems to treat the same waste input (2927 lbs/hr) in a single centralized facility operating 4032 hours per year for 20 years. This inventory consisted of a wide range of combustible and non-combustible materials such as paper, plastics, metals, concrete, soils, sludges, liquids, etc., contaminated with trace quantities of radioactive materials and RCRA regulated wastes. From this inventory, an average waste profile was developed for simulated treatment using ASPEN PLUS copyright for mass balance calculations. Seven representative thermal systems were selected for comparison with the five nonthermal systems. This report presents the comparisons against the TSWG principles, of total life cycle cost (TLCC), and of other system performance indicators such as energy requirements, reagent requirements, land use, final waste volume, aqueous and gaseous effluents, etc

Corrosion susceptibility study of candidate pin materials for ALTC (Active Lithium/Thionyl Chloride) batteries

Science.gov (United States)

Bovard, Francine S.; Cieslak, Wendy R.

1987-09-01

The corrosion susceptibilities of eight alternate battery pin material candidates for ALTC (Active Lithium/Thionyl Chloride) batteries in 1.5M LiAlCl4/SOCl2 electrolyte have been investigated using ampule exposure and electrochemical tests. The thermal expansion coefficients of these candidate materials are expected to match Sandia-developed Li-corrosion resistant glasses. The corrosion resistances of the candidate materials, which included three stainless steels (15-5 PH, 17-4 PH, and 446), three Fe-Ni glass sealing alloys (Kovar, Alloy 52, and Niromet 426), a Ni-based alloy (Hastelloy B-2) and a zirconium-based alloy (Zircaloy), were compared to the reference materials Ni and 316L SS. All of the candidate materials showed some evidence of corrosion and, therefore, did not perform as well as the reference materials. The Hastelloy B-2 and Zircaloy are clearly unacceptable materials for this application. Of the remaining alternate materials, the 446 SS and Alloy 52 are the most promising candidates.

Evaluation of Critical Thinking and Reflective Thinking Skills among Science Teacher Candidates

Science.gov (United States)

Demir, Sibel

2015-01-01

The aim of this study was to evaluate and determine the critical thinking and reflective thinking skills of science teacher candidates. The study was performed with the participation of 30 teacher candidates enrolled in the science teaching department of a university in Turkey. Scales administered during the study included the California Critical…

Additive Manufacturing: Which DLA-Managed Legacy Parts are Potential AM Candidates

Science.gov (United States)

2016-07-01

R G ADDITIVE MANUFACTURING : WHICH DLA-MANAGED LEGACY PARTS ARE POTENTIAL AM CANDIDATES? REPORT DL501T1 J UL Y 2016...L Y 2 0 1 6 ADDITIVE MANUFACTURING : WHICH DLA-MANAGED LEGACY PARTS ARE POTENTIAL AM CANDIDATES? REPORT DL501T1 Thomas K . Pa rk s...DESIGNATED BY OTHER OFFICIAL DOCUMENTATION. LMI © 2016. ALL RIGHTS RESERVED. iii Additive Manufacturing : Which DLA-Managed Legacy Parts Are

Multiomics Data Triangulation for Asthma Candidate Biomarkers and Precision Medicine.

Science.gov (United States)

Pecak, Matija; Korošec, Peter; Kunej, Tanja

2018-06-01

Asthma is a common complex disorder and has been subject to intensive omics research for disease susceptibility and therapeutic innovation. Candidate biomarkers of asthma and its precision treatment demand that they stand the test of multiomics data triangulation before they can be prioritized for clinical applications. We classified the biomarkers of asthma after a search of the literature and based on whether or not a given biomarker candidate is reported in multiple omics platforms and methodologies, using PubMed and Web of Science, we identified omics studies of asthma conducted on diverse platforms using keywords, such as asthma, genomics, metabolomics, and epigenomics. We extracted data about asthma candidate biomarkers from 73 articles and developed a catalog of 190 potential asthma biomarkers (167 human, 23 animal data), comprising DNA loci, transcripts, proteins, metabolites, epimutations, and noncoding RNAs. The data were sorted according to 13 omics types: genomics, epigenomics, transcriptomics, proteomics, interactomics, metabolomics, ncRNAomics, glycomics, lipidomics, environmental omics, pharmacogenomics, phenomics, and integrative omics. Importantly, we found that 10 candidate biomarkers were apparent in at least two or more omics levels, thus promising potential for further biomarker research and development and precision medicine applications. This multiomics catalog reported herein for the first time contributes to future decision-making on prioritization of biomarkers and validation efforts for precision medicine in asthma. The findings may also facilitate meta-analyses and integrative omics studies in the future.

Implementation of Statistical Process Control: Evaluating the Mechanical Performance of a Candidate Silicone Elastomer Docking Seal

Science.gov (United States)

Oravec, Heather Ann; Daniels, Christopher C.

2014-01-01

The National Aeronautics and Space Administration has been developing a novel docking system to meet the requirements of future exploration missions to low-Earth orbit and beyond. A dynamic gas pressure seal is located at the main interface between the active and passive mating components of the new docking system. This seal is designed to operate in the harsh space environment, but is also to perform within strict loading requirements while maintaining an acceptable level of leak rate. In this study, a candidate silicone elastomer seal was designed, and multiple subscale test articles were manufactured for evaluation purposes. The force required to fully compress each test article at room temperature was quantified and found to be below the maximum allowable load for the docking system. However, a significant amount of scatter was observed in the test results. Due to the stochastic nature of the mechanical performance of this candidate docking seal, a statistical process control technique was implemented to isolate unusual compression behavior from typical mechanical performance. The results of this statistical analysis indicated a lack of process control, suggesting a variation in the manufacturing phase of the process. Further investigation revealed that changes in the manufacturing molding process had occurred which may have influenced the mechanical performance of the seal. This knowledge improves the chance of this and future space seals to satisfy or exceed design specifications.

A Study to Investigate Whether Consistent Cognitive Functioning Cuts across Number, Space, and Time Conceptualization.

Science.gov (United States)

Brittan, Elizabeth

1979-01-01

Provides data incongruent with Piaget's idea of a concrete operational stage. Shows no clear-cut termination of preconceptual thinking and no simultaneous conceptual development in the three content areas (number, space, and time). (Author/RL)

Candidíase vulvovaginal: fatores predisponentes do hospedeiro e virulência das leveduras

OpenAIRE

Álvares,Cassiana Aparecida; Svidzinski,Terezinha Inez Estivalet; Consolaro,Márcia Edilaine Lopes

2007-01-01

INTRODUÇÃO: Leveduras do gênero Candida são patógenos oportunistas freqüentemente isolados das superfícies mucosas de indivíduos normais, mas podem levar ao desenvolvimento de infecções denominadas candidíases, que variam desde lesões superficiais até infecções disseminadas. OBJETIVOS: Ampliar os conhecimentos sobre candidíase vulvovaginal (CVV: infecção de vulva e vagina, causada por leveduras comensais que habitam a mucosa vaginal) e candidíase vulvovaginal recorrente (CVVR: ocorrência de q...

Reducing stigma and discrimination: Candidate interventions

OpenAIRE

Thornicroft, Graham; Brohan, Elaine; Kassam, Aliya; Lewis-Holmes, Elanor

2008-01-01

Abstract This paper proposes that stigma in relation to people with mental illness can be understood as a combination of problems of knowledge (ignorance), attitudes (prejudice) and behaviour (discrimination). From a literature review, a series of candidate interventions are identified which may be effective in reducing stigmatisation and discrimination at the following levels: individuals with mental illness and their family members; the workplace; and local, national and international. The ...

Educational intervention for liver transplantation candidates

OpenAIRE

Mendes,Karina Dal Sasso; Silva Junior,Orlando de Castro e; Ziviani,Luciana da Costa; Rossin,Fabiana Murad; Zago,Márcia Maria Fontão; Galvão,Cristina Maria

2013-01-01

OBJECTIVE: The objective in this study was to analyze candidates' knowledge on the liver transplantation process before and after putting in practice an educational intervention. METHOD: A quasi-experimental, one-group pretest-posttest research design was adopted. The final sample included 15 subjects. Research data were collected between January and March 2010 in three phases, which were: pretest, implementation of the educational intervention (two meetings) and posttest. RESULTS: The result...

Identification of Inherited Retinal Disease-Associated Genetic Variants in 11 Candidate Genes.

Science.gov (United States)

Astuti, Galuh D N; van den Born, L Ingeborgh; Khan, M Imran; Hamel, Christian P; Bocquet, Béatrice; Manes, Gaël; Quinodoz, Mathieu; Ali, Manir; Toomes, Carmel; McKibbin, Martin; El-Asrag, Mohammed E; Haer-Wigman, Lonneke; Inglehearn, Chris F; Black, Graeme C M; Hoyng, Carel B; Cremers, Frans P M; Roosing, Susanne

2018-01-10

Inherited retinal diseases (IRDs) display an enormous genetic heterogeneity. Whole exome sequencing (WES) recently identified genes that were mutated in a small proportion of IRD cases. Consequently, finding a second case or family carrying pathogenic variants in the same candidate gene often is challenging. In this study, we searched for novel candidate IRD gene-associated variants in isolated IRD families, assessed their causality, and searched for novel genotype-phenotype correlations. Whole exome sequencing was performed in 11 probands affected with IRDs. Homozygosity mapping data was available for five cases. Variants with minor allele frequencies ≤ 0.5% in public databases were selected as candidate disease-causing variants. These variants were ranked based on their: (a) presence in a gene that was previously implicated in IRD; (b) minor allele frequency in the Exome Aggregation Consortium database (ExAC); (c) in silico pathogenicity assessment using the combined annotation dependent depletion (CADD) score; and (d) interaction of the corresponding protein with known IRD-associated proteins. Twelve unique variants were found in 11 different genes in 11 IRD probands. Novel autosomal recessive and dominant inheritance patterns were found for variants in Small Nuclear Ribonucleoprotein U5 Subunit 200 ( SNRNP200 ) and Zinc Finger Protein 513 ( ZNF513 ), respectively. Using our pathogenicity assessment, a variant in DEAH-Box Helicase 32 ( DHX32 ) was the top ranked novel candidate gene to be associated with IRDs, followed by eight medium and lower ranked candidate genes. The identification of candidate disease-associated sequence variants in 11 single families underscores the notion that the previously identified IRD-associated genes collectively carry > 90% of the defects implicated in IRDs. To identify multiple patients or families with variants in the same gene and thereby provide extra proof for pathogenicity, worldwide data sharing is needed.

Going positive: The effects of negative and positive advertising on candidate success and voter turnout

Directory of Open Access Journals (Sweden)

Liam C Malloy

2016-01-01

Full Text Available Given the depth of research on negative advertising in campaigns, scholars have wondered why candidates continue to attack their opponents. We build on this research by considering real-world campaign contexts in which candidates are working in competition with each other and have to react to the decisions of the opposing campaign. Our results suggest that it is never efficacious for candidates to run attack ads, but running positive ads can increase a candidate’s margin of victory. These results are conditioned by two factors: candidates must both stay positive and out-advertise their opponent. Second, the effects of positive advertising are strongest in areas where the candidate is losing or winning by a large margin—areas where they might be tempted to not advertise at all.

The prediction of candidate genes for cervix related cancer through gene ontology and graph theoretical approach.

Science.gov (United States)

Hindumathi, V; Kranthi, T; Rao, S B; Manimaran, P

2014-06-01

With rapidly changing technology, prediction of candidate genes has become an indispensable task in recent years mainly in the field of biological research. The empirical methods for candidate gene prioritization that succors to explore the potential pathway between genetic determinants and complex diseases are highly cumbersome and labor intensive. In such a scenario predicting potential targets for a disease state through in silico approaches are of researcher's interest. The prodigious availability of protein interaction data coupled with gene annotation renders an ease in the accurate determination of disease specific candidate genes. In our work we have prioritized the cervix related cancer candidate genes by employing Csaba Ortutay and his co-workers approach of identifying the candidate genes through graph theoretical centrality measures and gene ontology. With the advantage of the human protein interaction data, cervical cancer gene sets and the ontological terms, we were able to predict 15 novel candidates for cervical carcinogenesis. The disease relevance of the anticipated candidate genes was corroborated through a literature survey. Also the presence of the drugs for these candidates was detected through Therapeutic Target Database (TTD) and DrugMap Central (DMC) which affirms that they may be endowed as potential drug targets for cervical cancer.

77 FR 20886 - Proposed Information Collection (Advertising, Sales, and Enrollment Materials, and Candidate...

Science.gov (United States)

2012-04-06

... (Advertising, Sales, and Enrollment Materials, and Candidate Handbooks) Activity: Comment Request AGENCY... the Office of Management and Budget (OMB) for each collection of information they conduct or sponsor... information technology. Title: Advertising, Sales, and Enrollment Materials, and Candidate Handbooks, 38 CFR...

Low-cost concepts for dry transfer of spent fuel and waste between storage and transportation casks

International Nuclear Information System (INIS)

Schneider, K.L.

1984-01-01

The federal government may provide interim storage for spent fuel from commercial nuclear power reactors that have used up their available storage capacity. One of the leading candidate concepts for this interim storage is to place spent fuel in large metal shielding casks. The Federal Interim Storage (FIS) site may not have the capability to transfer spent fuel from transportation casks to storage casks and vice versa. Thus, there may be an incentive to construct a relatively inexpensive but reliable intercask transfer system for use at an FIS site. This report documents the results of a preliminary study of preconceptual design and analysis of four intercask transfer concepts. The four concepts are: a large shielded cylindrical turntable that contains an integral fuel handling machine (turntable concept); a shielded fuel handling machine under which shipping and storage casks are moved horizontally (shuttle concept); a small hot cell containing equipment for transferring fuel betwee shipping and storage casks (that enter and leave the cell on carts) in a bifurcated trench (trench concept) and a large hot cell, shielded by an earthen berm, that houses equipment for handling fuel between casks that enter and leave the cell on a single cart (igloo concept). Information derived for each of the concepts is operating, capital and relocation costs; implementation and relocation time requirements; and overall characteristics

LOD score exclusion analyses for candidate genes using random population samples.

Science.gov (United States)

Deng, H W; Li, J; Recker, R R

2001-05-01

While extensive analyses have been conducted to test for, no formal analyses have been conducted to test against, the importance of candidate genes with random population samples. We develop a LOD score approach for exclusion analyses of candidate genes with random population samples. Under this approach, specific genetic effects and inheritance models at candidate genes can be analysed and if a LOD score is < or = - 2.0, the locus can be excluded from having an effect larger than that specified. Computer simulations show that, with sample sizes often employed in association studies, this approach has high power to exclude a gene from having moderate genetic effects. In contrast to regular association analyses, population admixture will not affect the robustness of our analyses; in fact, it renders our analyses more conservative and thus any significant exclusion result is robust. Our exclusion analysis complements association analysis for candidate genes in random population samples and is parallel to the exclusion mapping analyses that may be conducted in linkage analyses with pedigrees or relative pairs. The usefulness of the approach is demonstrated by an application to test the importance of vitamin D receptor and estrogen receptor genes underlying the differential risk to osteoporotic fractures.

Towards Treating Chemistry Teacher Candidates as Human

Science.gov (United States)

Lewthwaite, Brian Ellis

2008-01-01

This research inquiry investigates the factors influencing chemistry teacher candidates' development during their extended practica in the second and final year of an After-Degree Bachelor of Education at a university in central Canada. A variety of data sources are used to identify the risk and protective factors impeding and contributing to the…

Promoting Team Leadership Skills in Doctoral Candidates

Science.gov (United States)

Suleiman, Mahmoud; Whetton, Danny

2014-01-01

Doctoral programs can serve as an optimal opportunity for candidates to engage in tasks and activities to transform them and their schools. The paradigm shifts in such preparation involve moving from sitting and getting to making and taking. Most importantly, it requires building leadership skills and styles necessary to bring about desired change…

ANALYSIS OF BUDGET DEFICIT IN THE CANDIDATE COUNTRIES FOR EU MEMBERSHIP

Directory of Open Access Journals (Sweden)

Danijela Despotović

2017-11-01

Full Text Available The problems of deficit and debt are the traditional drivers of the recession in the past. Due to the high impact of the budget deficit to increase in indebtedness and deterioration of a macroeconomic performance, the European Union in Maastricht Treaty and later in the Pact of Stability and Growth strictly defined fiscal criteria which the member states should adhere to. Fiscal criteria are particularly important when it comes to candidate countries for EU membership. The aim of this paper is that, through theoretical and empirical basis perform a comparative analysis of the budget deficit in EU countries and candidates for membership in the EU, to rank the 34 countries according to the criteria of public finances and to show the causality between the candidate countries for membership of the EU and EU member states.

Planetary transit candidates in the CoRoT-SRc01 field

DEFF Research Database (Denmark)

Erikson, A.; Santerne, A.; Renner, S.

2012-01-01

Context. CoRoT is a pioneering space mission whose primary goals are stellar seismology and extrasolar planets search. Its surveys of large stellar fields generate numerous planetary candidates whose lightcurves have transit-like features. An extensive analytical and observational follow-up effort...... is undertaken to classify these candidates. Aims. We present the list of planetary transit candidates from the CoRoT LRa01 star field in the Monoceros constellation toward the Galactic anti-center direction. The CoRoT observations of LRa01 lasted from 24 October 2007 to 3 March 2008. Methods. We acquired...... and analyzed 7470 chromatic and 3938 monochromatic lightcurves. Instrumental noise and stellar variability were treated with several filtering tools by different teams from the CoRoT community. Different transit search algorithms were applied to the lightcurves. Results. Fifty-one stars were classified...

Multiplexed mass spectrometry monitoring of biomarker candidates for osteoarthritis.

Science.gov (United States)

Fernández-Puente, Patricia; Calamia, Valentina; González-Rodríguez, Lucía; Lourido, Lucía; Camacho-Encina, María; Oreiro, Natividad; Ruiz-Romero, Cristina; Blanco, Francisco J

2017-01-30

The methods currently available for the diagnosis and monitoring of osteoarthritis (OA) are very limited and lack sensitivity. Being the most prevalent rheumatic disease, one of the most disabling pathologies worldwide and currently untreatable, there is a considerable interest pointed in the verification of specific biological markers for improving its diagnosis and disease progression studies. Considering the remarkable development of targeted proteomics methodologies in the frame of the Human Proteome Project, the aim of this work was to develop and apply a MRM-based method for the multiplexed analysis of a panel of 6 biomarker candidates for OA encoded by the Chromosome 16, and another 8 proteins identified in previous shotgun studies as related with this pathology, in specimens derived from the human joint and serum. The method, targeting 35 different peptides, was applied to samples from human articular chondrocytes, healthy and osteoarthritic cartilage, synovial fluid and serum. Subsequently, a verification analysis of the biomarker value of these proteins was performed by single point measurements on a set of 116 serum samples, leading to the identification of increased amounts of Haptoglobin and von Willebrand Factor in OA patients. Altogether, the present work provides a tool for the multiplexed monitoring of 14 biomarker candidates for OA, and verifies for the first time the increased amount of two of these circulating markers in patients diagnosed with this disease. We have developed an MRM method for the identification and relative quantification of a panel of 14 protein biomarker candidates for osteoarthritis. This method has been applied to analyze human articular chondrocytes, articular cartilage, synovial fluid, and finally a collection of 116 serum samples from healthy controls and patients suffering different degrees of osteoarthritis, in order to verify the biomarker usefulness of the candidates. HPT and VWF were validated as increased in OA

The Electability of Women Candidates in The Election of Central Java DPRD in 2014

Directory of Open Access Journals (Sweden)

Fitriyah Fitriyah

2015-03-01

Full Text Available The study aims to analyze the factors supporting the electability of women candidates in Central Java DPRD election 2014. This type of research is descriptive. Techniques of data collection used the in-depth interviews with all women members of the Central Java DPRD election results 2014. Data processing techniques are data reduction, data display, concluding and verifying. The study found women candidate’s electability factors because they master/control the political capital, social capital and economics capital. By political capital (party officials so candidate nominated in small number candidacy and electoral district party base. Social capital (activists of social/professional organizations support the loyalty and solidity candidate team and candidate voice, and economics capital to support the political cost. Some of them have kinship with the party elite /social elite so openly their access to social and politics capital. An open list proportional electoral system makes it difficult increasing women representation if not followed party policy affirmations committed. In order to reach the 30% the representation of women in the legislature should be intervention laws forcing the party implementing gender justice policies candidacyPenelitian ini bermaksud menganalisa  faktor-faktor pendukung keterpilihan caleg perempuan di DPRD Jawa Tengah dalam Pemilu 2014. Tipe penelitian ini deskriptif.Teknik pengumpulan data  menggunakan wawancara mendalam terhadap seluruh perempuan anggota DPRD Jawa Tengah hasil Pemilu 2014. Teknik pengolahan data dalam penelitian ini adalah reduksi data, display data, penarikan kesimpulan dan verifikasi. Hasil Penelitian menemukan faktor-faktor keterpilihan caleg perempuan karena mereka menguasai modal politik (pengurus partai sehingga dicalonkan dinomor urut kecil dan dapil basis partai, modal sosial (pengurus organisasi sosial/profesi yang membantu kerja dan mendapat dukungan suara, dan modal ekonomi untuk biaya

Characterisation of a candidate dual AGN

Science.gov (United States)

Lena, D.; Panizo-Espinar, G.; Jonker, P. G.; Torres, M.; Heida, M.

2018-05-01

We present Chandra and optical observations of a candidate dual AGN discovered serendipitously while searching for recoiling black holes via a cross-correlation between the serendipitous XMM source catalog (2XMMi) and SDSS-DR7 galaxies with a separation no larger than ten times the sum of their Petrosian radii. The system has a stellar mass ratio M1/M2 ≈ 0.7. One of the galaxies (Source 1) shows clear evidence for AGN activity in the form of hard X-ray emission and optical emission-line diagnostics typical of AGN ionisation. The nucleus of the other galaxy (Source 2) has a soft X-ray spectrum, bluer colours, and optical emission line ratios dominated by stellar photoionisation with a "composite" signature, which might indicate the presence of a weak AGN. When plotted on a diagram with X-ray luminosity vs [OIII] luminosity both nuclei fall within the locus defined by local Seyfert galaxies. From the optical spectrum we estimate the electron densities finding n1 active nature of Source 1 can be established with confidence, whether the nucleus of Source 2 is active remains a matter of debate. Evidence that a faint AGN might reside in its nucleus is, however, tantalising.

Identification of novel type 2 diabetes candidate genes involved in the crosstalk between the mitochondrial and the insulin signaling systems.

Directory of Open Access Journals (Sweden)

Josep M Mercader

Full Text Available Type 2 Diabetes (T2D is a highly prevalent chronic metabolic disease with strong co-morbidity with obesity and cardiovascular diseases. There is growing evidence supporting the notion that a crosstalk between mitochondria and the insulin signaling cascade could be involved in the etiology of T2D and insulin resistance. In this study we investigated the molecular basis of this crosstalk by using systems biology approaches. We combined, filtered, and interrogated different types of functional interaction data, such as direct protein-protein interactions, co-expression analyses, and metabolic and signaling dependencies. As a result, we constructed the mitochondria-insulin (MITIN network, which highlights 286 genes as candidate functional linkers between these two systems. The results of internal gene expression analysis of three independent experimental models of mitochondria and insulin signaling perturbations further support the connecting roles of these genes. In addition, we further assessed whether these genes are involved in the etiology of T2D using the genome-wide association study meta-analysis from the DIAGRAM consortium, involving 8,130 T2D cases and 38,987 controls. We found modest enrichment of genes associated with T2D amongst our linker genes (p = 0.0549, including three already validated T2D SNPs and 15 additional SNPs, which, when combined, were collectively associated to increased fasting glucose levels according to MAGIC genome wide meta-analysis (p = 8.12×10(-5. This study highlights the potential of combining systems biology, experimental, and genome-wide association data mining for identifying novel genes and related variants that increase vulnerability to complex diseases.